data_9BNY
# 
_entry.id   9BNY 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BNY         pdb_00009bny 10.2210/pdb9bny/pdb 
WWPDB D_1000282925 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-12 ? 
2 'Structure model' 1 1 2025-03-12 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
_pdbx_audit_revision_category.ordinal             1 
_pdbx_audit_revision_category.revision_ordinal    2 
_pdbx_audit_revision_category.data_content_type   'Structure model' 
_pdbx_audit_revision_category.category            citation 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
5 2 'Structure model' '_citation.title'                   
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BNY 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-03 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              karen.anderson@yale.edu 
_pdbx_contact_author.name_first         Karen 
_pdbx_contact_author.name_last          Anderson 
_pdbx_contact_author.name_mi            S 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3433-0780 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Papini, C.'     1 0000-0002-6098-4959 
'Kenneson, J.'   2 ?                   
'Anderson, K.S.' 3 0000-0003-3433-0780 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acs Bio Med Chem Au' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2694-2437 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            5 
_citation.language                  ? 
_citation.page_first                215 
_citation.page_last                 226 
_citation.title                     
'Exploring Possible Drug-Resistant Variants of SARS-CoV-2 Main Protease (M pro ) with Noncovalent Preclinical Candidate, Mpro61.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acsbiomedchemau.4c00109 
_citation.pdbx_database_id_PubMed   39990941 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kenneson, J.R.'  1 ? 
primary 'Papini, C.'      2 ? 
primary 'Tang, S.'        3 ? 
primary 'Huynh, K.'       4 ? 
primary 'Zhang, C.H.'     5 ? 
primary 'Jorgensen, W.L.' 6 ? 
primary 'Anderson, K.S.'  7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man '3C-like proteinase nsp5' 33829.578 1  3.4.22.69 E166V,L50F ? ? 
2 water   nat water                     18.015    75 ?         ?          ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMFNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMVLPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMFNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMVLPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   GLY n 
1 3   PHE n 
1 4   ARG n 
1 5   LYS n 
1 6   MET n 
1 7   ALA n 
1 8   PHE n 
1 9   PRO n 
1 10  SER n 
1 11  GLY n 
1 12  LYS n 
1 13  VAL n 
1 14  GLU n 
1 15  GLY n 
1 16  CYS n 
1 17  MET n 
1 18  VAL n 
1 19  GLN n 
1 20  VAL n 
1 21  THR n 
1 22  CYS n 
1 23  GLY n 
1 24  THR n 
1 25  THR n 
1 26  THR n 
1 27  LEU n 
1 28  ASN n 
1 29  GLY n 
1 30  LEU n 
1 31  TRP n 
1 32  LEU n 
1 33  ASP n 
1 34  ASP n 
1 35  VAL n 
1 36  VAL n 
1 37  TYR n 
1 38  CYS n 
1 39  PRO n 
1 40  ARG n 
1 41  HIS n 
1 42  VAL n 
1 43  ILE n 
1 44  CYS n 
1 45  THR n 
1 46  SER n 
1 47  GLU n 
1 48  ASP n 
1 49  MET n 
1 50  PHE n 
1 51  ASN n 
1 52  PRO n 
1 53  ASN n 
1 54  TYR n 
1 55  GLU n 
1 56  ASP n 
1 57  LEU n 
1 58  LEU n 
1 59  ILE n 
1 60  ARG n 
1 61  LYS n 
1 62  SER n 
1 63  ASN n 
1 64  HIS n 
1 65  ASN n 
1 66  PHE n 
1 67  LEU n 
1 68  VAL n 
1 69  GLN n 
1 70  ALA n 
1 71  GLY n 
1 72  ASN n 
1 73  VAL n 
1 74  GLN n 
1 75  LEU n 
1 76  ARG n 
1 77  VAL n 
1 78  ILE n 
1 79  GLY n 
1 80  HIS n 
1 81  SER n 
1 82  MET n 
1 83  GLN n 
1 84  ASN n 
1 85  CYS n 
1 86  VAL n 
1 87  LEU n 
1 88  LYS n 
1 89  LEU n 
1 90  LYS n 
1 91  VAL n 
1 92  ASP n 
1 93  THR n 
1 94  ALA n 
1 95  ASN n 
1 96  PRO n 
1 97  LYS n 
1 98  THR n 
1 99  PRO n 
1 100 LYS n 
1 101 TYR n 
1 102 LYS n 
1 103 PHE n 
1 104 VAL n 
1 105 ARG n 
1 106 ILE n 
1 107 GLN n 
1 108 PRO n 
1 109 GLY n 
1 110 GLN n 
1 111 THR n 
1 112 PHE n 
1 113 SER n 
1 114 VAL n 
1 115 LEU n 
1 116 ALA n 
1 117 CYS n 
1 118 TYR n 
1 119 ASN n 
1 120 GLY n 
1 121 SER n 
1 122 PRO n 
1 123 SER n 
1 124 GLY n 
1 125 VAL n 
1 126 TYR n 
1 127 GLN n 
1 128 CYS n 
1 129 ALA n 
1 130 MET n 
1 131 ARG n 
1 132 PRO n 
1 133 ASN n 
1 134 PHE n 
1 135 THR n 
1 136 ILE n 
1 137 LYS n 
1 138 GLY n 
1 139 SER n 
1 140 PHE n 
1 141 LEU n 
1 142 ASN n 
1 143 GLY n 
1 144 SER n 
1 145 CYS n 
1 146 GLY n 
1 147 SER n 
1 148 VAL n 
1 149 GLY n 
1 150 PHE n 
1 151 ASN n 
1 152 ILE n 
1 153 ASP n 
1 154 TYR n 
1 155 ASP n 
1 156 CYS n 
1 157 VAL n 
1 158 SER n 
1 159 PHE n 
1 160 CYS n 
1 161 TYR n 
1 162 MET n 
1 163 HIS n 
1 164 HIS n 
1 165 MET n 
1 166 VAL n 
1 167 LEU n 
1 168 PRO n 
1 169 THR n 
1 170 GLY n 
1 171 VAL n 
1 172 HIS n 
1 173 ALA n 
1 174 GLY n 
1 175 THR n 
1 176 ASP n 
1 177 LEU n 
1 178 GLU n 
1 179 GLY n 
1 180 ASN n 
1 181 PHE n 
1 182 TYR n 
1 183 GLY n 
1 184 PRO n 
1 185 PHE n 
1 186 VAL n 
1 187 ASP n 
1 188 ARG n 
1 189 GLN n 
1 190 THR n 
1 191 ALA n 
1 192 GLN n 
1 193 ALA n 
1 194 ALA n 
1 195 GLY n 
1 196 THR n 
1 197 ASP n 
1 198 THR n 
1 199 THR n 
1 200 ILE n 
1 201 THR n 
1 202 VAL n 
1 203 ASN n 
1 204 VAL n 
1 205 LEU n 
1 206 ALA n 
1 207 TRP n 
1 208 LEU n 
1 209 TYR n 
1 210 ALA n 
1 211 ALA n 
1 212 VAL n 
1 213 ILE n 
1 214 ASN n 
1 215 GLY n 
1 216 ASP n 
1 217 ARG n 
1 218 TRP n 
1 219 PHE n 
1 220 LEU n 
1 221 ASN n 
1 222 ARG n 
1 223 PHE n 
1 224 THR n 
1 225 THR n 
1 226 THR n 
1 227 LEU n 
1 228 ASN n 
1 229 ASP n 
1 230 PHE n 
1 231 ASN n 
1 232 LEU n 
1 233 VAL n 
1 234 ALA n 
1 235 MET n 
1 236 LYS n 
1 237 TYR n 
1 238 ASN n 
1 239 TYR n 
1 240 GLU n 
1 241 PRO n 
1 242 LEU n 
1 243 THR n 
1 244 GLN n 
1 245 ASP n 
1 246 HIS n 
1 247 VAL n 
1 248 ASP n 
1 249 ILE n 
1 250 LEU n 
1 251 GLY n 
1 252 PRO n 
1 253 LEU n 
1 254 SER n 
1 255 ALA n 
1 256 GLN n 
1 257 THR n 
1 258 GLY n 
1 259 ILE n 
1 260 ALA n 
1 261 VAL n 
1 262 LEU n 
1 263 ASP n 
1 264 MET n 
1 265 CYS n 
1 266 ALA n 
1 267 SER n 
1 268 LEU n 
1 269 LYS n 
1 270 GLU n 
1 271 LEU n 
1 272 LEU n 
1 273 GLN n 
1 274 ASN n 
1 275 GLY n 
1 276 MET n 
1 277 ASN n 
1 278 GLY n 
1 279 ARG n 
1 280 THR n 
1 281 ILE n 
1 282 LEU n 
1 283 GLY n 
1 284 SER n 
1 285 ALA n 
1 286 LEU n 
1 287 LEU n 
1 288 GLU n 
1 289 ASP n 
1 290 GLU n 
1 291 PHE n 
1 292 THR n 
1 293 PRO n 
1 294 PHE n 
1 295 ASP n 
1 296 VAL n 
1 297 VAL n 
1 298 ARG n 
1 299 GLN n 
1 300 CYS n 
1 301 SER n 
1 302 GLY n 
1 303 VAL n 
1 304 THR n 
1 305 PHE n 
1 306 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   306 
_entity_src_gen.gene_src_common_name               '2019-nCoV, SARS-CoV-2' 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'rep, 1a-1b' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1   1   SER SER A . n 
A 1 2   GLY 2   2   2   GLY GLY A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ARG 4   4   4   ARG ARG A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   MET 6   6   6   MET MET A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  CYS 16  16  16  CYS CYS A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  THR 21  21  21  THR THR A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  ASN 28  28  28  ASN ASN A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  TRP 31  31  31  TRP TRP A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  ASP 34  34  34  ASP ASP A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  CYS 38  38  38  CYS CYS A . n 
A 1 39  PRO 39  39  39  PRO PRO A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  CYS 44  44  44  CYS CYS A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  MET 49  49  49  MET MET A . n 
A 1 50  PHE 50  50  50  PHE PHE A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  ASP 56  56  56  ASP ASP A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  HIS 64  64  64  HIS HIS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  MET 82  82  82  MET MET A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  CYS 85  85  85  CYS CYS A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  ASP 92  92  92  ASP ASP A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  PRO 99  99  99  PRO PRO A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ARG 105 105 105 ARG ARG A . n 
A 1 106 ILE 106 106 106 ILE ILE A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 PHE 134 134 134 PHE PHE A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 CYS 145 145 145 CYS CYS A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 ASP 153 153 153 ASP ASP A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 CYS 156 156 156 CYS CYS A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 CYS 160 160 160 CYS CYS A . n 
A 1 161 TYR 161 161 161 TYR TYR A . n 
A 1 162 MET 162 162 162 MET MET A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 MET 165 165 165 MET MET A . n 
A 1 166 VAL 166 166 166 VAL VAL A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 HIS 172 172 172 HIS HIS A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 GLN 189 189 189 GLN GLN A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 GLN 192 192 192 GLN GLN A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 ILE 200 200 200 ILE ILE A . n 
A 1 201 THR 201 201 201 THR THR A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 TRP 207 207 207 TRP TRP A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ARG 217 217 217 ARG ARG A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ASN 221 221 221 ASN ASN A . n 
A 1 222 ARG 222 222 222 ARG ARG A . n 
A 1 223 PHE 223 223 223 PHE PHE A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 MET 235 235 235 MET MET A . n 
A 1 236 LYS 236 236 236 LYS LYS A . n 
A 1 237 TYR 237 237 237 TYR TYR A . n 
A 1 238 ASN 238 238 238 ASN ASN A . n 
A 1 239 TYR 239 239 239 TYR TYR A . n 
A 1 240 GLU 240 240 240 GLU GLU A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 THR 243 243 243 THR THR A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 ASP 248 248 248 ASP ASP A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 THR 257 257 257 THR THR A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 CYS 265 265 265 CYS CYS A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 LYS 269 269 269 LYS LYS A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 ASN 274 274 274 ASN ASN A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 ASN 277 277 277 ASN ASN A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 SER 284 284 284 SER SER A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 PHE 291 291 291 PHE PHE A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 PRO 293 293 293 PRO PRO A . n 
A 1 294 PHE 294 294 294 PHE PHE A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 VAL 296 296 296 VAL VAL A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLN 299 299 299 GLN GLN A . n 
A 1 300 CYS 300 300 300 CYS CYS A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 GLY 302 302 302 GLY GLY A . n 
A 1 303 VAL 303 303 303 VAL VAL A . n 
A 1 304 THR 304 304 304 THR THR A . n 
A 1 305 PHE 305 305 ?   ?   ?   A . n 
A 1 306 GLN 306 306 ?   ?   ?   A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 HOH 1  401 76 HOH HOH A . 
B 2 HOH 2  402 6  HOH HOH A . 
B 2 HOH 3  403 73 HOH HOH A . 
B 2 HOH 4  404 46 HOH HOH A . 
B 2 HOH 5  405 39 HOH HOH A . 
B 2 HOH 6  406 9  HOH HOH A . 
B 2 HOH 7  407 25 HOH HOH A . 
B 2 HOH 8  408 5  HOH HOH A . 
B 2 HOH 9  409 34 HOH HOH A . 
B 2 HOH 10 410 31 HOH HOH A . 
B 2 HOH 11 411 72 HOH HOH A . 
B 2 HOH 12 412 10 HOH HOH A . 
B 2 HOH 13 413 22 HOH HOH A . 
B 2 HOH 14 414 71 HOH HOH A . 
B 2 HOH 15 415 12 HOH HOH A . 
B 2 HOH 16 416 13 HOH HOH A . 
B 2 HOH 17 417 77 HOH HOH A . 
B 2 HOH 18 418 49 HOH HOH A . 
B 2 HOH 19 419 51 HOH HOH A . 
B 2 HOH 20 420 48 HOH HOH A . 
B 2 HOH 21 421 60 HOH HOH A . 
B 2 HOH 22 422 19 HOH HOH A . 
B 2 HOH 23 423 16 HOH HOH A . 
B 2 HOH 24 424 61 HOH HOH A . 
B 2 HOH 25 425 44 HOH HOH A . 
B 2 HOH 26 426 27 HOH HOH A . 
B 2 HOH 27 427 42 HOH HOH A . 
B 2 HOH 28 428 8  HOH HOH A . 
B 2 HOH 29 429 2  HOH HOH A . 
B 2 HOH 30 430 7  HOH HOH A . 
B 2 HOH 31 431 29 HOH HOH A . 
B 2 HOH 32 432 55 HOH HOH A . 
B 2 HOH 33 433 53 HOH HOH A . 
B 2 HOH 34 434 4  HOH HOH A . 
B 2 HOH 35 435 35 HOH HOH A . 
B 2 HOH 36 436 36 HOH HOH A . 
B 2 HOH 37 437 21 HOH HOH A . 
B 2 HOH 38 438 3  HOH HOH A . 
B 2 HOH 39 439 70 HOH HOH A . 
B 2 HOH 40 440 15 HOH HOH A . 
B 2 HOH 41 441 54 HOH HOH A . 
B 2 HOH 42 442 41 HOH HOH A . 
B 2 HOH 43 443 14 HOH HOH A . 
B 2 HOH 44 444 26 HOH HOH A . 
B 2 HOH 45 445 1  HOH HOH A . 
B 2 HOH 46 446 32 HOH HOH A . 
B 2 HOH 47 447 64 HOH HOH A . 
B 2 HOH 48 448 62 HOH HOH A . 
B 2 HOH 49 449 56 HOH HOH A . 
B 2 HOH 50 450 57 HOH HOH A . 
B 2 HOH 51 451 23 HOH HOH A . 
B 2 HOH 52 452 74 HOH HOH A . 
B 2 HOH 53 453 65 HOH HOH A . 
B 2 HOH 54 454 30 HOH HOH A . 
B 2 HOH 55 455 52 HOH HOH A . 
B 2 HOH 56 456 18 HOH HOH A . 
B 2 HOH 57 457 47 HOH HOH A . 
B 2 HOH 58 458 37 HOH HOH A . 
B 2 HOH 59 459 59 HOH HOH A . 
B 2 HOH 60 460 45 HOH HOH A . 
B 2 HOH 61 461 43 HOH HOH A . 
B 2 HOH 62 462 50 HOH HOH A . 
B 2 HOH 63 463 33 HOH HOH A . 
B 2 HOH 64 464 24 HOH HOH A . 
B 2 HOH 65 465 38 HOH HOH A . 
B 2 HOH 66 466 67 HOH HOH A . 
B 2 HOH 67 467 66 HOH HOH A . 
B 2 HOH 68 468 40 HOH HOH A . 
B 2 HOH 69 469 75 HOH HOH A . 
B 2 HOH 70 470 68 HOH HOH A . 
B 2 HOH 71 471 69 HOH HOH A . 
B 2 HOH 72 472 28 HOH HOH A . 
B 2 HOH 73 473 63 HOH HOH A . 
B 2 HOH 74 474 20 HOH HOH A . 
B 2 HOH 75 475 58 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A SER 46  ? OG  ? A SER 46  OG  
2  1 Y 1 A GLU 47  ? CG  ? A GLU 47  CG  
3  1 Y 1 A GLU 47  ? CD  ? A GLU 47  CD  
4  1 Y 1 A GLU 47  ? OE1 ? A GLU 47  OE1 
5  1 Y 1 A GLU 47  ? OE2 ? A GLU 47  OE2 
6  1 Y 1 A PHE 50  ? CG  ? A PHE 50  CG  
7  1 Y 1 A PHE 50  ? CD1 ? A PHE 50  CD1 
8  1 Y 1 A PHE 50  ? CD2 ? A PHE 50  CD2 
9  1 Y 1 A PHE 50  ? CE1 ? A PHE 50  CE1 
10 1 Y 1 A PHE 50  ? CE2 ? A PHE 50  CE2 
11 1 Y 1 A PHE 50  ? CZ  ? A PHE 50  CZ  
12 1 Y 1 A ARG 60  ? CG  ? A ARG 60  CG  
13 1 Y 1 A ARG 60  ? CD  ? A ARG 60  CD  
14 1 Y 1 A ARG 60  ? NE  ? A ARG 60  NE  
15 1 Y 1 A ARG 60  ? CZ  ? A ARG 60  CZ  
16 1 Y 1 A ARG 60  ? NH1 ? A ARG 60  NH1 
17 1 Y 1 A ARG 60  ? NH2 ? A ARG 60  NH2 
18 1 Y 1 A LEU 67  ? CG  ? A LEU 67  CG  
19 1 Y 1 A LEU 67  ? CD1 ? A LEU 67  CD1 
20 1 Y 1 A LEU 67  ? CD2 ? A LEU 67  CD2 
21 1 Y 1 A GLN 69  ? CG  ? A GLN 69  CG  
22 1 Y 1 A GLN 69  ? CD  ? A GLN 69  CD  
23 1 Y 1 A GLN 69  ? OE1 ? A GLN 69  OE1 
24 1 Y 1 A GLN 69  ? NE2 ? A GLN 69  NE2 
25 1 Y 1 A ASN 72  ? CG  ? A ASN 72  CG  
26 1 Y 1 A ASN 72  ? OD1 ? A ASN 72  OD1 
27 1 Y 1 A ASN 72  ? ND2 ? A ASN 72  ND2 
28 1 Y 1 A VAL 73  ? CG1 ? A VAL 73  CG1 
29 1 Y 1 A VAL 73  ? CG2 ? A VAL 73  CG2 
30 1 Y 1 A ARG 76  ? CG  ? A ARG 76  CG  
31 1 Y 1 A ARG 76  ? CD  ? A ARG 76  CD  
32 1 Y 1 A ARG 76  ? NE  ? A ARG 76  NE  
33 1 Y 1 A ARG 76  ? CZ  ? A ARG 76  CZ  
34 1 Y 1 A ARG 76  ? NH1 ? A ARG 76  NH1 
35 1 Y 1 A ARG 76  ? NH2 ? A ARG 76  NH2 
36 1 Y 1 A LYS 100 ? CG  ? A LYS 100 CG  
37 1 Y 1 A LYS 100 ? CD  ? A LYS 100 CD  
38 1 Y 1 A LYS 100 ? CE  ? A LYS 100 CE  
39 1 Y 1 A LYS 100 ? NZ  ? A LYS 100 NZ  
40 1 Y 1 A TYR 118 ? CG  ? A TYR 118 CG  
41 1 Y 1 A TYR 118 ? CD1 ? A TYR 118 CD1 
42 1 Y 1 A TYR 118 ? CD2 ? A TYR 118 CD2 
43 1 Y 1 A TYR 118 ? CE1 ? A TYR 118 CE1 
44 1 Y 1 A TYR 118 ? CE2 ? A TYR 118 CE2 
45 1 Y 1 A TYR 118 ? CZ  ? A TYR 118 CZ  
46 1 Y 1 A TYR 118 ? OH  ? A TYR 118 OH  
47 1 Y 1 A ASN 142 ? CG  ? A ASN 142 CG  
48 1 Y 1 A ASN 142 ? OD1 ? A ASN 142 OD1 
49 1 Y 1 A ASN 142 ? ND2 ? A ASN 142 ND2 
50 1 Y 1 A ASP 153 ? CG  ? A ASP 153 CG  
51 1 Y 1 A ASP 153 ? OD1 ? A ASP 153 OD1 
52 1 Y 1 A ASP 153 ? OD2 ? A ASP 153 OD2 
53 1 Y 1 A TYR 154 ? CG  ? A TYR 154 CG  
54 1 Y 1 A TYR 154 ? CD1 ? A TYR 154 CD1 
55 1 Y 1 A TYR 154 ? CD2 ? A TYR 154 CD2 
56 1 Y 1 A TYR 154 ? CE1 ? A TYR 154 CE1 
57 1 Y 1 A TYR 154 ? CE2 ? A TYR 154 CE2 
58 1 Y 1 A TYR 154 ? CZ  ? A TYR 154 CZ  
59 1 Y 1 A TYR 154 ? OH  ? A TYR 154 OH  
60 1 Y 1 A ARG 222 ? CG  ? A ARG 222 CG  
61 1 Y 1 A ARG 222 ? CD  ? A ARG 222 CD  
62 1 Y 1 A ARG 222 ? NE  ? A ARG 222 NE  
63 1 Y 1 A ARG 222 ? CZ  ? A ARG 222 CZ  
64 1 Y 1 A ARG 222 ? NH1 ? A ARG 222 NH1 
65 1 Y 1 A ARG 222 ? NH2 ? A ARG 222 NH2 
66 1 Y 1 A LEU 232 ? CG  ? A LEU 232 CG  
67 1 Y 1 A LEU 232 ? CD1 ? A LEU 232 CD1 
68 1 Y 1 A LEU 232 ? CD2 ? A LEU 232 CD2 
69 1 Y 1 A GLU 240 ? CG  ? A GLU 240 CG  
70 1 Y 1 A GLU 240 ? CD  ? A GLU 240 CD  
71 1 Y 1 A GLU 240 ? OE1 ? A GLU 240 OE1 
72 1 Y 1 A GLU 240 ? OE2 ? A GLU 240 OE2 
73 1 Y 1 A ASN 277 ? CG  ? A ASN 277 CG  
74 1 Y 1 A ASN 277 ? OD1 ? A ASN 277 OD1 
75 1 Y 1 A ASN 277 ? ND2 ? A ASN 277 ND2 
76 1 Y 1 A ARG 279 ? CG  ? A ARG 279 CG  
77 1 Y 1 A ARG 279 ? CD  ? A ARG 279 CD  
78 1 Y 1 A ARG 279 ? NE  ? A ARG 279 NE  
79 1 Y 1 A ARG 279 ? CZ  ? A ARG 279 CZ  
80 1 Y 1 A ARG 279 ? NH1 ? A ARG 279 NH1 
81 1 Y 1 A ARG 279 ? NH2 ? A ARG 279 NH2 
82 1 Y 1 A VAL 303 ? CG1 ? A VAL 303 CG1 
83 1 Y 1 A VAL 303 ? CG2 ? A VAL 303 CG2 
84 1 Y 1 A THR 304 ? OG1 ? A THR 304 OG1 
85 1 Y 1 A THR 304 ? CG2 ? A THR 304 CG2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   101.312 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BNY 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     113.249 
_cell.length_a_esd                 ? 
_cell.length_b                     54.013 
_cell.length_b_esd                 ? 
_cell.length_c                     44.978 
_cell.length_c_esd                 ? 
_cell.volume                       269782.026 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BNY 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y' 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BNY 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             1.99 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          38.31 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M BIS-TRIS, 20% w/v Polyethylene glycol 1,500' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            294 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-09-15 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.979330 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSLS-II BEAMLINE 17-ID-2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.979330 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID-2 
_diffrn_source.pdbx_synchrotron_site       NSLS-II 
# 
_reflns.B_iso_Wilson_estimate                          35.58 
_reflns.entry_id                                       9BNY 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.83 
_reflns.d_resolution_low                               44.10 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     22567 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           95.14 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                4.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          10.38 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   1 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.07749 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.83 
_reflns_shell.d_res_low                                     1.895 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           0.89 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2359 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               5.1 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.429 
_reflns_shell.pdbx_CC_star                                  0.775 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          98.99 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.632 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               44.53 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9BNY 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.83 
_refine.ls_d_res_low                             44.10 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     22567 
_refine.ls_number_reflns_R_free                  1110 
_refine.ls_number_reflns_R_work                  21457 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    95.16 
_refine.ls_percent_reflns_R_free                 4.92 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2489 
_refine.ls_R_factor_R_free                       0.2701 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2478 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 35.0809 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3190 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.83 
_refine_hist.d_res_low                        44.10 
_refine_hist.number_atoms_solvent             75 
_refine_hist.number_atoms_total               2338 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2263 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0031  ? 2324 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.5817  ? 3170 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0422  ? 366  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0041  ? 413  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 12.3525 ? 804  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.83 1.90  . . 119 2547 98.56  . . . . 0.3810 . . . . . . . . . . . 0.4068 
'X-RAY DIFFRACTION' 1.93 2.01  . . 130 2383 99.88  . . . . 0.3333 . . . . . . . . . . . 0.3406 
'X-RAY DIFFRACTION' 2.01 2.14  . . 152 2807 99.93  . . . . 0.3261 . . . . . . . . . . . 0.3500 
'X-RAY DIFFRACTION' 2.14 2.30  . . 114 2400 86.13  . . . . 0.3221 . . . . . . . . . . . 0.3671 
'X-RAY DIFFRACTION' 2.30 2.54  . . 157 2795 100.00 . . . . 0.3025 . . . . . . . . . . . 0.3506 
'X-RAY DIFFRACTION' 2.54 2.90  . . 138 2824 99.93  . . . . 0.2911 . . . . . . . . . . . 0.3075 
'X-RAY DIFFRACTION' 2.90 3.66  . . 152 2820 99.80  . . . . 0.2448 . . . . . . . . . . . 0.2581 
'X-RAY DIFFRACTION' 3.66 44.10 . . 148 2881 99.74  . . . . 0.1906 . . . . . . . . . . . 0.2162 
# 
_struct.entry_id                     9BNY 
_struct.title                        'Crystal Structure of E166V/L50F SARS-CoV-2 Main Protease' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BNY 
_struct_keywords.text            'Hydrolase, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1AB_SARS2 
_struct_ref.pdbx_db_accession          P0DTD1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_struct_ref.pdbx_align_begin           3264 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9BNY 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 306 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P0DTD1 
_struct_ref_seq.db_align_beg                  3264 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3569 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       306 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9BNY PHE A 50  ? UNP P0DTD1 LEU 3313 'engineered mutation' 50  1 
1 9BNY VAL A 166 ? UNP P0DTD1 GLU 3429 'engineered mutation' 166 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 3030  ? 
1 MORE         -15   ? 
1 'SSA (A^2)'  24180 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000 0.0000000000 0.0000000000  0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000  
2 'crystal symmetry operation' 2_556 -x,y,-z+1 -1.0000000000 0.0000000000 0.0000000000 -8.8225030394 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 44.1042392987 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 10  ? GLY A 15  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 41  ? CYS A 44  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 GLU A 47  ? ASN A 51  ? GLU A 47  ASN A 51  5 ? 5  
HELX_P HELX_P4  AA4 ASN A 53  ? ARG A 60  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P5  AA5 LYS A 61  ? HIS A 64  ? LYS A 61  HIS A 64  5 ? 4  
HELX_P HELX_P6  AA6 ILE A 200 ? ASN A 214 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P7  AA7 THR A 226 ? TYR A 237 ? THR A 226 TYR A 237 1 ? 12 
HELX_P HELX_P8  AA8 THR A 243 ? LEU A 250 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P9  AA9 LEU A 250 ? GLY A 258 ? LEU A 250 GLY A 258 1 ? 9  
HELX_P HELX_P10 AB1 ALA A 260 ? GLY A 275 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P11 AB2 THR A 292 ? GLY A 302 ? THR A 292 GLY A 302 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 73  ? LEU A 75  ? VAL A 73  LEU A 75  
AA1 2 PHE A 66  ? ALA A 70  ? PHE A 66  ALA A 70  
AA1 3 MET A 17  ? CYS A 22  ? MET A 17  CYS A 22  
AA1 4 THR A 25  ? LEU A 32  ? THR A 25  LEU A 32  
AA1 5 VAL A 35  ? PRO A 39  ? VAL A 35  PRO A 39  
AA1 6 VAL A 86  ? VAL A 91  ? VAL A 86  VAL A 91  
AA1 7 VAL A 77  ? GLN A 83  ? VAL A 77  GLN A 83  
AA2 1 TYR A 101 ? PHE A 103 ? TYR A 101 PHE A 103 
AA2 2 CYS A 156 ? VAL A 166 ? CYS A 156 VAL A 166 
AA2 3 VAL A 148 ? ASP A 153 ? VAL A 148 ASP A 153 
AA2 4 THR A 111 ? TYR A 118 ? THR A 111 TYR A 118 
AA2 5 SER A 121 ? ALA A 129 ? SER A 121 ALA A 129 
AA3 1 TYR A 101 ? PHE A 103 ? TYR A 101 PHE A 103 
AA3 2 CYS A 156 ? VAL A 166 ? CYS A 156 VAL A 166 
AA3 3 HIS A 172 ? THR A 175 ? HIS A 172 THR A 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 73  ? O VAL A 73  N ALA A 70  ? N ALA A 70  
AA1 2 3 O LEU A 67  ? O LEU A 67  N THR A 21  ? N THR A 21  
AA1 3 4 N VAL A 18  ? N VAL A 18  O GLY A 29  ? O GLY A 29  
AA1 4 5 N LEU A 30  ? N LEU A 30  O TYR A 37  ? O TYR A 37  
AA1 5 6 N CYS A 38  ? N CYS A 38  O LEU A 87  ? O LEU A 87  
AA1 6 7 O LYS A 90  ? O LYS A 90  N ILE A 78  ? N ILE A 78  
AA2 1 2 N LYS A 102 ? N LYS A 102 O PHE A 159 ? O PHE A 159 
AA2 2 3 O SER A 158 ? O SER A 158 N ASN A 151 ? N ASN A 151 
AA2 3 4 O PHE A 150 ? O PHE A 150 N SER A 113 ? N SER A 113 
AA2 4 5 N ALA A 116 ? N ALA A 116 O SER A 123 ? O SER A 123 
AA3 1 2 N LYS A 102 ? N LYS A 102 O PHE A 159 ? O PHE A 159 
AA3 2 3 N MET A 165 ? N MET A 165 O ALA A 173 ? O ALA A 173 
# 
_pdbx_entry_details.entry_id                   9BNY 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 48.60   -129.91 
2 1 ASN A 51  ? ? -153.92 75.55   
3 1 ASN A 84  ? ? 50.21   -121.25 
4 1 TYR A 154 ? ? 62.40   -94.92  
5 1 HIS A 164 ? ? -120.73 -50.67  
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 467 ? B HOH . 
2 1 A HOH 474 ? B HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 -x,y,-z         
3 x+1/2,y+1/2,z   
4 -x+1/2,y+1/2,-z 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A PHE 305 ? A PHE 305 
2 1 Y 1 A GLN 306 ? A GLN 306 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' 'P30 GM133893' 1 
'Department of Energy (DOE, United States)'                                                'United States' KP1607011      2 
'Other government'                                                                         'United States' DE-SC0012704   3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7NF5 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'C 1 2 1' 
_space_group.name_Hall        'C 2y' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9BNY 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.008830 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.001766 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.018514 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.022674 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . SER A 1 1   ? -2.18609  -22.06463 38.78185  1.000 47.64241  ? 1   SER A N    1 
ATOM   2    C CA   . SER A 1 1   ? -1.81632  -20.70633 38.28355  1.000 45.34469  ? 1   SER A CA   1 
ATOM   3    C C    . SER A 1 1   ? -1.78369  -20.68757 36.75531  1.000 46.28152  ? 1   SER A C    1 
ATOM   4    O O    . SER A 1 1   ? -1.55042  -21.71672 36.12381  1.000 44.45890  ? 1   SER A O    1 
ATOM   5    C CB   . SER A 1 1   ? -0.46207  -20.27802 38.84864  1.000 49.13167  ? 1   SER A CB   1 
ATOM   6    O OG   . SER A 1 1   ? 0.57783   -21.12610 38.38791  1.000 56.04601  ? 1   SER A OG   1 
ATOM   7    H H1   . SER A 1 1   ? -2.87086  -22.37829 38.30770  1.000 57.90696  ? 1   SER A H1   1 
ATOM   8    H H2   . SER A 1 1   ? -1.48976  -22.61209 38.69526  1.000 57.90696  ? 1   SER A H2   1 
ATOM   9    H H3   . SER A 1 1   ? -2.41803  -22.01297 39.63954  1.000 57.90696  ? 1   SER A H3   1 
ATOM   10   H HA   . SER A 1 1   ? -2.47761  -20.06244 38.58190  1.000 55.14969  ? 1   SER A HA   1 
ATOM   11   H HB2  . SER A 1 1   ? -0.27596  -19.36953 38.56421  1.000 59.69408  ? 1   SER A HB2  1 
ATOM   12   H HB3  . SER A 1 1   ? -0.49754  -20.32180 39.81700  1.000 59.69408  ? 1   SER A HB3  1 
ATOM   13   H HG   . SER A 1 1   ? 1.26103   -20.67152 38.20848  1.000 67.99128  ? 1   SER A HG   1 
ATOM   14   N N    . GLY A 1 2   ? -2.01333  -19.51673 36.17237  1.000 43.36213  ? 2   GLY A N    1 
ATOM   15   C CA   . GLY A 1 2   ? -2.00483  -19.35990 34.73510  1.000 44.65917  ? 2   GLY A CA   1 
ATOM   16   C C    . GLY A 1 2   ? -3.31527  -19.79146 34.09862  1.000 43.21711  ? 2   GLY A C    1 
ATOM   17   O O    . GLY A 1 2   ? -4.07421  -20.60384 34.63249  1.000 42.79590  ? 2   GLY A O    1 
ATOM   18   H H    . GLY A 1 2   ? -2.17886  -18.78906 36.59980  1.000 52.77063  ? 2   GLY A H    1 
ATOM   19   H HA2  . GLY A 1 2   ? -1.85011  -18.42803 34.51470  1.000 54.32707  ? 2   GLY A HA2  1 
ATOM   20   H HA3  . GLY A 1 2   ? -1.29028  -19.89650 34.35778  1.000 54.32707  ? 2   GLY A HA3  1 
ATOM   21   N N    . PHE A 1 3   ? -3.58426  -19.22740 32.92192  1.000 41.53173  ? 3   PHE A N    1 
ATOM   22   C CA   . PHE A 1 3   ? -4.81497  -19.53095 32.19619  1.000 39.73564  ? 3   PHE A CA   1 
ATOM   23   C C    . PHE A 1 3   ? -4.52497  -19.58913 30.70528  1.000 39.86795  ? 3   PHE A C    1 
ATOM   24   O O    . PHE A 1 3   ? -4.08389  -18.59846 30.11554  1.000 40.63914  ? 3   PHE A O    1 
ATOM   25   C CB   . PHE A 1 3   ? -5.90603  -18.49349 32.47865  1.000 39.50185  ? 3   PHE A CB   1 
ATOM   26   C CG   . PHE A 1 3   ? -7.29121  -18.99554 32.21281  1.000 41.82491  ? 3   PHE A CG   1 
ATOM   27   C CD1  . PHE A 1 3   ? -7.93093  -19.79829 33.14362  1.000 42.33809  ? 3   PHE A CD1  1 
ATOM   28   C CD2  . PHE A 1 3   ? -7.95118  -18.67660 31.04150  1.000 37.71651  ? 3   PHE A CD2  1 
ATOM   29   C CE1  . PHE A 1 3   ? -9.20696  -20.27146 32.91129  1.000 41.70419  ? 3   PHE A CE1  1 
ATOM   30   C CE2  . PHE A 1 3   ? -9.22658  -19.14364 30.80355  1.000 40.40514  ? 3   PHE A CE2  1 
ATOM   31   C CZ   . PHE A 1 3   ? -9.85601  -19.94320 31.73762  1.000 40.32964  ? 3   PHE A CZ   1 
ATOM   32   H H    . PHE A 1 3   ? -3.06884  -18.66564 32.52395  1.000 50.57415  ? 3   PHE A H    1 
ATOM   33   H HA   . PHE A 1 3   ? -5.13105  -20.40306 32.47974  1.000 48.41883  ? 3   PHE A HA   1 
ATOM   34   H HB2  . PHE A 1 3   ? -5.85781  -18.23516 33.41238  1.000 48.13829  ? 3   PHE A HB2  1 
ATOM   35   H HB3  . PHE A 1 3   ? -5.75655  -17.72027 31.91236  1.000 48.13829  ? 3   PHE A HB3  1 
ATOM   36   H HD1  . PHE A 1 3   ? -7.49539  -20.02106 33.93455  1.000 51.54177  ? 3   PHE A HD1  1 
ATOM   37   H HD2  . PHE A 1 3   ? -7.53102  -18.14164 30.40733  1.000 45.99588  ? 3   PHE A HD2  1 
ATOM   38   H HE1  . PHE A 1 3   ? -9.62767  -20.80915 33.54279  1.000 50.78110  ? 3   PHE A HE1  1 
ATOM   39   H HE2  . PHE A 1 3   ? -9.66334  -18.92011 30.01350  1.000 49.22224  ? 3   PHE A HE2  1 
ATOM   40   H HZ   . PHE A 1 3   ? -10.71543 -20.25987 31.57628  1.000 49.13164  ? 3   PHE A HZ   1 
ATOM   41   N N    . ARG A 1 4   ? -4.79965  -20.74013 30.09643  1.000 42.22508  ? 4   ARG A N    1 
ATOM   42   C CA   . ARG A 1 4   ? -4.48366  -20.98556 28.70002  1.000 39.88967  ? 4   ARG A CA   1 
ATOM   43   C C    . ARG A 1 4   ? -5.70683  -21.50693 27.96508  1.000 36.03791  ? 4   ARG A C    1 
ATOM   44   O O    . ARG A 1 4   ? -6.53509  -22.22402 28.53239  1.000 36.19022  ? 4   ARG A O    1 
ATOM   45   C CB   . ARG A 1 4   ? -3.34807  -22.00707 28.55567  1.000 38.59965  ? 4   ARG A CB   1 
ATOM   46   C CG   . ARG A 1 4   ? -1.95397  -21.45073 28.73066  1.000 42.17492  ? 4   ARG A CG   1 
ATOM   47   C CD   . ARG A 1 4   ? -1.40505  -20.92206 27.41450  1.000 44.39564  ? 4   ARG A CD   1 
ATOM   48   N NE   . ARG A 1 4   ? 0.03489   -20.70938 27.48671  1.000 49.58225  ? 4   ARG A NE   1 
ATOM   49   C CZ   . ARG A 1 4   ? 0.74906   -20.08475 26.56130  1.000 65.96658  ? 4   ARG A CZ   1 
ATOM   50   N NH1  . ARG A 1 4   ? 0.19041   -19.61119 25.46044  1.000 91.34118  ? 4   ARG A NH1  1 
ATOM   51   N NH2  . ARG A 1 4   ? 2.05584   -19.92319 26.74925  1.000 51.28154  ? 4   ARG A NH2  1 
ATOM   52   H H    . ARG A 1 4   ? -5.17816  -21.40790 30.48427  1.000 51.40616  ? 4   ARG A H    1 
ATOM   53   H HA   . ARG A 1 4   ? -4.21490  -20.14876 28.28962  1.000 48.60368  ? 4   ARG A HA   1 
ATOM   54   H HB2  . ARG A 1 4   ? -3.47066  -22.69754 29.22585  1.000 47.05564  ? 4   ARG A HB2  1 
ATOM   55   H HB3  . ARG A 1 4   ? -3.39604  -22.39440 27.66766  1.000 47.05564  ? 4   ARG A HB3  1 
ATOM   56   H HG2  . ARG A 1 4   ? -1.97570  -20.72059 29.36888  1.000 51.34597  ? 4   ARG A HG2  1 
ATOM   57   H HG3  . ARG A 1 4   ? -1.36427  -22.15208 29.04889  1.000 51.34597  ? 4   ARG A HG3  1 
ATOM   58   H HD2  . ARG A 1 4   ? -1.58412  -21.56451 26.71016  1.000 54.01084  ? 4   ARG A HD2  1 
ATOM   59   H HD3  . ARG A 1 4   ? -1.82904  -20.07482 27.20639  1.000 54.01084  ? 4   ARG A HD3  1 
ATOM   60   H HE   . ARG A 1 4   ? 0.44982   -21.00991 28.17745  1.000 60.23477  ? 4   ARG A HE   1 
ATOM   61   H HH11 . ARG A 1 4   ? -0.65476  -19.70540 25.33235  1.000 110.34548 ? 4   ARG A HH11 1 
ATOM   62   H HH12 . ARG A 1 4   ? 0.67223   -19.20897 24.87249  1.000 110.34548 ? 4   ARG A HH12 1 
ATOM   63   H HH21 . ARG A 1 4   ? 2.42762   -20.22252 27.46464  1.000 62.27391  ? 4   ARG A HH21 1 
ATOM   64   H HH22 . ARG A 1 4   ? 2.52900   -19.51940 26.15539  1.000 62.27391  ? 4   ARG A HH22 1 
ATOM   65   N N    . LYS A 1 5   ? -5.80585  -21.14598 26.68964  1.000 37.54187  ? 5   LYS A N    1 
ATOM   66   C CA   . LYS A 1 5   ? -6.78965  -21.76132 25.80615  1.000 37.89240  ? 5   LYS A CA   1 
ATOM   67   C C    . LYS A 1 5   ? -6.40041  -23.22298 25.61929  1.000 35.45153  ? 5   LYS A C    1 
ATOM   68   O O    . LYS A 1 5   ? -5.36375  -23.52922 25.01975  1.000 35.80540  ? 5   LYS A O    1 
ATOM   69   C CB   . LYS A 1 5   ? -6.85125  -21.01710 24.48036  1.000 38.83065  ? 5   LYS A CB   1 
ATOM   70   C CG   . LYS A 1 5   ? -8.07946  -21.35005 23.65935  1.000 40.08259  ? 5   LYS A CG   1 
ATOM   71   C CD   . LYS A 1 5   ? -8.27082  -20.35586 22.53317  1.000 43.31433  ? 5   LYS A CD   1 
ATOM   72   C CE   . LYS A 1 5   ? -9.01451  -19.12080 23.01018  1.000 50.14508  ? 5   LYS A CE   1 
ATOM   73   N NZ   . LYS A 1 5   ? -9.18060  -18.12751 21.91564  1.000 83.47998  ? 5   LYS A NZ   1 
ATOM   74   H H    . LYS A 1 5   ? -5.31574  -20.54822 26.31271  1.000 45.78631  ? 5   LYS A H    1 
ATOM   75   H HA   . LYS A 1 5   ? -7.67552  -21.71559 26.19864  1.000 46.20695  ? 5   LYS A HA   1 
ATOM   76   H HB2  . LYS A 1 5   ? -6.86095  -20.06335 24.65689  1.000 47.33284  ? 5   LYS A HB2  1 
ATOM   77   H HB3  . LYS A 1 5   ? -6.06993  -21.24923 23.95447  1.000 47.33284  ? 5   LYS A HB3  1 
ATOM   78   H HG2  . LYS A 1 5   ? -7.97945  -22.23434 23.27343  1.000 48.83518  ? 5   LYS A HG2  1 
ATOM   79   H HG3  . LYS A 1 5   ? -8.86468  -21.32320 24.22821  1.000 48.83518  ? 5   LYS A HG3  1 
ATOM   80   H HD2  . LYS A 1 5   ? -7.40414  -20.07997 22.19606  1.000 52.71326  ? 5   LYS A HD2  1 
ATOM   81   H HD3  . LYS A 1 5   ? -8.78694  -20.76858 21.82312  1.000 52.71326  ? 5   LYS A HD3  1 
ATOM   82   H HE2  . LYS A 1 5   ? -9.89526  -19.37792 23.32494  1.000 60.91016  ? 5   LYS A HE2  1 
ATOM   83   H HE3  . LYS A 1 5   ? -8.51459  -18.70240 23.72846  1.000 60.91016  ? 5   LYS A HE3  1 
ATOM   84   H HZ1  . LYS A 1 5   ? -9.56885  -17.39074 22.22953  1.000 100.91204 ? 5   LYS A HZ1  1 
ATOM   85   H HZ2  . LYS A 1 5   ? -8.38637  -17.91318 21.57599  1.000 100.91204 ? 5   LYS A HZ2  1 
ATOM   86   H HZ3  . LYS A 1 5   ? -9.68854  -18.46877 21.26939  1.000 100.91204 ? 5   LYS A HZ3  1 
ATOM   87   N N    . MET A 1 6   ? -7.21941  -24.12584 26.14771  1.000 34.61971  ? 6   MET A N    1 
ATOM   88   C CA   . MET A 1 6   ? -6.82427  -25.50717 26.37348  1.000 34.47459  ? 6   MET A CA   1 
ATOM   89   C C    . MET A 1 6   ? -7.75678  -26.45217 25.63797  1.000 32.06232  ? 6   MET A C    1 
ATOM   90   O O    . MET A 1 6   ? -8.97656  -26.38483 25.80749  1.000 34.18450  ? 6   MET A O    1 
ATOM   91   C CB   . MET A 1 6   ? -6.83918  -25.81383 27.86996  1.000 35.11902  ? 6   MET A CB   1 
ATOM   92   C CG   . MET A 1 6   ? -6.23646  -27.14006 28.24162  1.000 32.67152  ? 6   MET A CG   1 
ATOM   93   S SD   . MET A 1 6   ? -5.96875  -27.23155 30.02046  1.000 42.18666  ? 6   MET A SD   1 
ATOM   94   C CE   . MET A 1 6   ? -4.86805  -25.84357 30.28763  1.000 38.59518  ? 6   MET A CE   1 
ATOM   95   H H    . MET A 1 6   ? -8.02735  -23.95580 26.38835  1.000 42.27972  ? 6   MET A H    1 
ATOM   96   H HA   . MET A 1 6   ? -5.92845  -25.64252 26.02694  1.000 42.10558  ? 6   MET A HA   1 
ATOM   97   H HB2  . MET A 1 6   ? -6.33677  -25.12426 28.33146  1.000 42.87889  ? 6   MET A HB2  1 
ATOM   98   H HB3  . MET A 1 6   ? -7.75969  -25.81454 28.17583  1.000 42.87889  ? 6   MET A HB3  1 
ATOM   99   H HG2  . MET A 1 6   ? -6.83831  -27.85496 27.98163  1.000 39.94189  ? 6   MET A HG2  1 
ATOM   100  H HG3  . MET A 1 6   ? -5.38253  -27.24598 27.79387  1.000 39.94189  ? 6   MET A HG3  1 
ATOM   101  H HE1  . MET A 1 6   ? -4.20960  -26.08698 30.95704  1.000 47.05028  ? 6   MET A HE1  1 
ATOM   102  H HE2  . MET A 1 6   ? -4.42564  -25.62600 29.45227  1.000 47.05028  ? 6   MET A HE2  1 
ATOM   103  H HE3  . MET A 1 6   ? -5.38681  -25.08372 30.59489  1.000 47.05028  ? 6   MET A HE3  1 
ATOM   104  N N    . ALA A 1 7   ? -7.18146  -27.33395 24.83369  1.000 30.68031  ? 7   ALA A N    1 
ATOM   105  C CA   . ALA A 1 7   ? -7.95312  -28.33772 24.11965  1.000 29.71753  ? 7   ALA A CA   1 
ATOM   106  C C    . ALA A 1 7   ? -8.07025  -29.60300 24.96004  1.000 30.55126  ? 7   ALA A C    1 
ATOM   107  O O    . ALA A 1 7   ? -7.27227  -29.85111 25.86523  1.000 31.34370  ? 7   ALA A O    1 
ATOM   108  C CB   . ALA A 1 7   ? -7.30404  -28.65130 22.77076  1.000 30.53828  ? 7   ALA A CB   1 
ATOM   109  H H    . ALA A 1 7   ? -6.33552  -27.37150 24.68341  1.000 37.55244  ? 7   ALA A H    1 
ATOM   110  H HA   . ALA A 1 7   ? -8.84739  -28.00370 23.94756  1.000 36.39710  ? 7   ALA A HA   1 
ATOM   111  H HB1  . ALA A 1 7   ? -7.85845  -29.28873 22.29410  1.000 37.38201  ? 7   ALA A HB1  1 
ATOM   112  H HB2  . ALA A 1 7   ? -7.22802  -27.83106 22.25859  1.000 37.38201  ? 7   ALA A HB2  1 
ATOM   113  H HB3  . ALA A 1 7   ? -6.42357  -29.02836 22.92404  1.000 37.38201  ? 7   ALA A HB3  1 
ATOM   114  N N    . PHE A 1 8   ? -9.09459  -30.39688 24.66567  1.000 30.22045  ? 8   PHE A N    1 
ATOM   115  C CA   . PHE A 1 8   ? -9.21281  -31.69273 25.31119  1.000 30.30812  ? 8   PHE A CA   1 
ATOM   116  C C    . PHE A 1 8   ? -8.11825  -32.62491 24.79450  1.000 30.23761  ? 8   PHE A C    1 
ATOM   117  O O    . PHE A 1 8   ? -7.66867  -32.48992 23.65440  1.000 30.62813  ? 8   PHE A O    1 
ATOM   118  C CB   . PHE A 1 8   ? -10.57558 -32.31732 25.04230  1.000 30.49869  ? 8   PHE A CB   1 
ATOM   119  C CG   . PHE A 1 8   ? -11.71281 -31.60599 25.70309  1.000 31.34590  ? 8   PHE A CG   1 
ATOM   120  C CD1  . PHE A 1 8   ? -12.03060 -31.85683 27.02719  1.000 35.79996  ? 8   PHE A CD1  1 
ATOM   121  C CD2  . PHE A 1 8   ? -12.47525 -30.69580 24.99478  1.000 32.06978  ? 8   PHE A CD2  1 
ATOM   122  C CE1  . PHE A 1 8   ? -13.08441 -31.20433 27.63504  1.000 39.96694  ? 8   PHE A CE1  1 
ATOM   123  C CE2  . PHE A 1 8   ? -13.52826 -30.04169 25.59434  1.000 35.53737  ? 8   PHE A CE2  1 
ATOM   124  C CZ   . PHE A 1 8   ? -13.83532 -30.29542 26.91620  1.000 40.83310  ? 8   PHE A CZ   1 
ATOM   125  H H    . PHE A 1 8   ? -9.72088  -30.21038 24.10658  1.000 37.00060  ? 8   PHE A H    1 
ATOM   126  H HA   . PHE A 1 8   ? -9.11831  -31.58538 26.27059  1.000 37.10581  ? 8   PHE A HA   1 
ATOM   127  H HB2  . PHE A 1 8   ? -10.73817 -32.30872 24.08606  1.000 37.33449  ? 8   PHE A HB2  1 
ATOM   128  H HB3  . PHE A 1 8   ? -10.56895 -33.23045 25.36949  1.000 37.33449  ? 8   PHE A HB3  1 
ATOM   129  H HD1  . PHE A 1 8   ? -11.52875 -32.47146 27.51224  1.000 43.69602  ? 8   PHE A HD1  1 
ATOM   130  H HD2  . PHE A 1 8   ? -12.27465 -30.52334 24.10320  1.000 39.21980  ? 8   PHE A HD2  1 
ATOM   131  H HE1  . PHE A 1 8   ? -13.28799 -31.37640 28.52602  1.000 48.69640  ? 8   PHE A HE1  1 
ATOM   132  H HE2  . PHE A 1 8   ? -14.03242 -29.42921 25.10898  1.000 43.38091  ? 8   PHE A HE2  1 
ATOM   133  H HZ   . PHE A 1 8   ? -14.54681 -29.85486 27.32189  1.000 49.73579  ? 8   PHE A HZ   1 
ATOM   134  N N    . PRO A 1 9   ? -7.67022  -33.58137 25.60622  1.000 31.05940  ? 9   PRO A N    1 
ATOM   135  C CA   . PRO A 1 9   ? -6.75357  -34.60328 25.08129  1.000 31.01882  ? 9   PRO A CA   1 
ATOM   136  C C    . PRO A 1 9   ? -7.40708  -35.30922 23.90192  1.000 31.14856  ? 9   PRO A C    1 
ATOM   137  O O    . PRO A 1 9   ? -8.56911  -35.71908 23.97054  1.000 32.12548  ? 9   PRO A O    1 
ATOM   138  C CB   . PRO A 1 9   ? -6.53424  -35.54198 26.27282  1.000 31.34456  ? 9   PRO A CB   1 
ATOM   139  C CG   . PRO A 1 9   ? -6.89331  -34.72500 27.48192  1.000 32.39867  ? 9   PRO A CG   1 
ATOM   140  C CD   . PRO A 1 9   ? -7.99668  -33.80459 27.02844  1.000 31.41727  ? 9   PRO A CD   1 
ATOM   141  H HA   . PRO A 1 9   ? -5.89803  -34.22615 24.82298  1.000 37.95865  ? 9   PRO A HA   1 
ATOM   142  H HB2  . PRO A 1 9   ? -7.11204  -36.31705 26.19336  1.000 38.34955  ? 9   PRO A HB2  1 
ATOM   143  H HB3  . PRO A 1 9   ? -5.60616  -35.82206 26.30611  1.000 38.34955  ? 9   PRO A HB3  1 
ATOM   144  H HG2  . PRO A 1 9   ? -7.20058  -35.30799 28.19369  1.000 39.61447  ? 9   PRO A HG2  1 
ATOM   145  H HG3  . PRO A 1 9   ? -6.12092  -34.21846 27.77814  1.000 39.61447  ? 9   PRO A HG3  1 
ATOM   146  H HD2  . PRO A 1 9   ? -8.86385  -34.22873 27.12337  1.000 38.43679  ? 9   PRO A HD2  1 
ATOM   147  H HD3  . PRO A 1 9   ? -7.97914  -32.97084 27.52387  1.000 38.43679  ? 9   PRO A HD3  1 
ATOM   148  N N    . SER A 1 10  ? -6.65867  -35.43367 22.81127  1.000 30.69352  ? 10  SER A N    1 
ATOM   149  C CA   . SER A 1 10  ? -7.21828  -35.86576 21.53921  1.000 30.82411  ? 10  SER A CA   1 
ATOM   150  C C    . SER A 1 10  ? -7.03466  -37.35095 21.26446  1.000 30.46472  ? 10  SER A C    1 
ATOM   151  O O    . SER A 1 10  ? -7.44350  -37.82070 20.19900  1.000 29.31685  ? 10  SER A O    1 
ATOM   152  C CB   . SER A 1 10  ? -6.59080  -35.05853 20.39605  1.000 30.74580  ? 10  SER A CB   1 
ATOM   153  O OG   . SER A 1 10  ? -5.19280  -35.30110 20.30653  1.000 30.61213  ? 10  SER A OG   1 
ATOM   154  H H    . SER A 1 10  ? -5.81455  -35.27138 22.78428  1.000 37.56829  ? 10  SER A H    1 
ATOM   155  H HA   . SER A 1 10  ? -8.17230  -35.69115 21.55496  1.000 37.72501  ? 10  SER A HA   1 
ATOM   156  H HB2  . SER A 1 10  ? -7.00956  -35.31809 19.56048  1.000 37.63103  ? 10  SER A HB2  1 
ATOM   157  H HB3  . SER A 1 10  ? -6.73654  -34.11378 20.56075  1.000 37.63103  ? 10  SER A HB3  1 
ATOM   158  H HG   . SER A 1 10  ? -4.96657  -35.38418 19.50185  1.000 37.47062  ? 10  SER A HG   1 
ATOM   159  N N    . GLY A 1 11  ? -6.45219  -38.10294 22.19720  1.000 30.62401  ? 11  GLY A N    1 
ATOM   160  C CA   . GLY A 1 11  ? -6.15224  -39.50126 21.92620  1.000 29.52560  ? 11  GLY A CA   1 
ATOM   161  C C    . GLY A 1 11  ? -7.35278  -40.30168 21.47145  1.000 30.27687  ? 11  GLY A C    1 
ATOM   162  O O    . GLY A 1 11  ? -7.29561  -41.01931 20.47094  1.000 34.69212  ? 11  GLY A O    1 
ATOM   163  H H    . GLY A 1 11  ? -6.22507  -37.83104 22.98084  1.000 37.48488  ? 11  GLY A H    1 
ATOM   164  H HA2  . GLY A 1 11  ? -5.47732  -39.55094 21.23128  1.000 36.16679  ? 11  GLY A HA2  1 
ATOM   165  H HA3  . GLY A 1 11  ? -5.80530  -39.91240 22.73335  1.000 36.16679  ? 11  GLY A HA3  1 
ATOM   166  N N    . LYS A 1 12  ? -8.46279  -40.19355 22.20323  1.000 31.70463  ? 12  LYS A N    1 
ATOM   167  C CA   . LYS A 1 12  ? -9.64313  -40.98521 21.87630  1.000 32.24408  ? 12  LYS A CA   1 
ATOM   168  C C    . LYS A 1 12  ? -10.12945 -40.72758 20.45703  1.000 34.79607  ? 12  LYS A C    1 
ATOM   169  O O    . LYS A 1 12  ? -10.69675 -41.62722 19.82346  1.000 34.00886  ? 12  LYS A O    1 
ATOM   170  C CB   . LYS A 1 12  ? -10.76163 -40.68818 22.87606  1.000 34.19630  ? 12  LYS A CB   1 
ATOM   171  C CG   . LYS A 1 12  ? -10.60406 -41.36135 24.22866  1.000 40.77824  ? 12  LYS A CG   1 
ATOM   172  C CD   . LYS A 1 12  ? -11.58630 -40.77681 25.23956  1.000 40.89813  ? 12  LYS A CD   1 
ATOM   173  C CE   . LYS A 1 12  ? -11.54334 -41.52235 26.56690  1.000 47.89077  ? 12  LYS A CE   1 
ATOM   174  N NZ   . LYS A 1 12  ? -10.17882 -41.51310 27.16175  1.000 49.85555  ? 12  LYS A NZ   1 
ATOM   175  H H    . LYS A 1 12  ? -8.55566  -39.67625 22.88395  1.000 38.78162  ? 12  LYS A H    1 
ATOM   176  H HA   . LYS A 1 12  ? -9.41108  -41.92463 21.94370  1.000 39.42897  ? 12  LYS A HA   1 
ATOM   177  H HB2  . LYS A 1 12  ? -10.79147 -39.73073 23.02869  1.000 41.77163  ? 12  LYS A HB2  1 
ATOM   178  H HB3  . LYS A 1 12  ? -11.60168 -40.98995 22.49638  1.000 41.77163  ? 12  LYS A HB3  1 
ATOM   179  H HG2  . LYS A 1 12  ? -10.78075 -42.31107 24.14087  1.000 49.66996  ? 12  LYS A HG2  1 
ATOM   180  H HG3  . LYS A 1 12  ? -9.70258  -41.22065 24.55795  1.000 49.66996  ? 12  LYS A HG3  1 
ATOM   181  H HD2  . LYS A 1 12  ? -11.36013 -39.84827 25.40555  1.000 49.81382  ? 12  LYS A HD2  1 
ATOM   182  H HD3  . LYS A 1 12  ? -12.48678 -40.84059 24.88464  1.000 49.81382  ? 12  LYS A HD3  1 
ATOM   183  H HE2  . LYS A 1 12  ? -12.15046 -41.09715 27.19260  1.000 58.20499  ? 12  LYS A HE2  1 
ATOM   184  H HE3  . LYS A 1 12  ? -11.80642 -42.44505 26.42436  1.000 58.20499  ? 12  LYS A HE3  1 
ATOM   185  H HZ1  . LYS A 1 12  ? -10.18989 -41.91619 27.95516  1.000 60.56273  ? 12  LYS A HZ1  1 
ATOM   186  H HZ2  . LYS A 1 12  ? -9.61096  -41.94240 26.62758  1.000 60.56273  ? 12  LYS A HZ2  1 
ATOM   187  H HZ3  . LYS A 1 12  ? -9.89850  -40.67504 27.26745  1.000 60.56273  ? 12  LYS A HZ3  1 
ATOM   188  N N    . VAL A 1 13  ? -9.92427  -39.51635 19.94417  1.000 31.20256  ? 13  VAL A N    1 
ATOM   189  C CA   . VAL A 1 13  ? -10.38850 -39.18672 18.60291  1.000 30.42600  ? 13  VAL A CA   1 
ATOM   190  C C    . VAL A 1 13  ? -9.37198  -39.58332 17.53637  1.000 30.70724  ? 13  VAL A C    1 
ATOM   191  O O    . VAL A 1 13  ? -9.75747  -39.90987 16.40983  1.000 33.53589  ? 13  VAL A O    1 
ATOM   192  C CB   . VAL A 1 13  ? -10.71981 -37.68754 18.50786  1.000 27.75783  ? 13  VAL A CB   1 
ATOM   193  C CG1  . VAL A 1 13  ? -11.27967 -37.34692 17.13544  1.000 29.45805  ? 13  VAL A CG1  1 
ATOM   194  C CG2  . VAL A 1 13  ? -11.69561 -37.29473 19.60317  1.000 29.76788  ? 13  VAL A CG2  1 
ATOM   195  H H    . VAL A 1 13  ? -9.52199  -38.87367 20.35003  1.000 38.17915  ? 13  VAL A H    1 
ATOM   196  H HA   . VAL A 1 13  ? -11.20209 -39.68570 18.42973  1.000 37.24727  ? 13  VAL A HA   1 
ATOM   197  H HB   . VAL A 1 13  ? -9.90492  -37.17573 18.62994  1.000 34.04547  ? 13  VAL A HB   1 
ATOM   198  H HG11 . VAL A 1 13  ? -11.58100 -36.42491 17.13725  1.000 36.08573  ? 13  VAL A HG11 1 
ATOM   199  H HG12 . VAL A 1 13  ? -10.58249 -37.46577 16.47158  1.000 36.08573  ? 13  VAL A HG12 1 
ATOM   200  H HG13 . VAL A 1 13  ? -12.02429 -37.93789 16.94257  1.000 36.08573  ? 13  VAL A HG13 1 
ATOM   201  H HG21 . VAL A 1 13  ? -12.02435 -36.39930 19.42702  1.000 36.45752  ? 13  VAL A HG21 1 
ATOM   202  H HG22 . VAL A 1 13  ? -12.43439 -37.92328 19.60827  1.000 36.45752  ? 13  VAL A HG22 1 
ATOM   203  H HG23 . VAL A 1 13  ? -11.23684 -37.31656 20.45755  1.000 36.45752  ? 13  VAL A HG23 1 
ATOM   204  N N    . GLU A 1 14  ? -8.07875  -39.55414 17.86152  1.000 30.39271  ? 14  GLU A N    1 
ATOM   205  C CA   . GLU A 1 14  ? -7.06590  -39.96769 16.89526  1.000 31.44331  ? 14  GLU A CA   1 
ATOM   206  C C    . GLU A 1 14  ? -7.33653  -41.38438 16.40074  1.000 34.15625  ? 14  GLU A C    1 
ATOM   207  O O    . GLU A 1 14  ? -7.32786  -41.64682 15.19378  1.000 35.69333  ? 14  GLU A O    1 
ATOM   208  C CB   . GLU A 1 14  ? -5.67003  -39.86765 17.51505  1.000 32.81992  ? 14  GLU A CB   1 
ATOM   209  C CG   . GLU A 1 14  ? -5.23328  -38.44965 17.86725  1.000 31.15233  ? 14  GLU A CG   1 
ATOM   210  C CD   . GLU A 1 14  ? -3.97203  -38.42357 18.71396  1.000 32.70123  ? 14  GLU A CD   1 
ATOM   211  O OE1  . GLU A 1 14  ? -3.04421  -39.21598 18.43246  1.000 34.08144  ? 14  GLU A OE1  1 
ATOM   212  O OE2  . GLU A 1 14  ? -3.90885  -37.62831 19.67322  1.000 33.18719  ? 14  GLU A OE2  1 
ATOM   213  H H    . GLU A 1 14  ? -7.76750  -39.30296 18.62286  1.000 37.20732  ? 14  GLU A H    1 
ATOM   214  H HA   . GLU A 1 14  ? -7.09551  -39.36768 16.13367  1.000 38.46804  ? 14  GLU A HA   1 
ATOM   215  H HB2  . GLU A 1 14  ? -5.65714  -40.38951 18.33260  1.000 40.11997  ? 14  GLU A HB2  1 
ATOM   216  H HB3  . GLU A 1 14  ? -5.02566  -40.22414 16.88370  1.000 40.11997  ? 14  GLU A HB3  1 
ATOM   217  H HG2  . GLU A 1 14  ? -5.05674  -37.95970 17.04891  1.000 38.11886  ? 14  GLU A HG2  1 
ATOM   218  H HG3  . GLU A 1 14  ? -5.94117  -38.01493 18.36805  1.000 38.11886  ? 14  GLU A HG3  1 
ATOM   219  N N    . GLY A 1 15  ? -7.61332  -42.30318 17.31487  1.000 35.26278  ? 15  GLY A N    1 
ATOM   220  C CA   . GLY A 1 15  ? -7.90129  -43.66918 16.94564  1.000 39.35890  ? 15  GLY A CA   1 
ATOM   221  C C    . GLY A 1 15  ? -9.10833  -43.85063 16.04550  1.000 38.24265  ? 15  GLY A C    1 
ATOM   222  O O    . GLY A 1 15  ? -9.39128  -44.95882 15.58904  1.000 41.41315  ? 15  GLY A O    1 
ATOM   223  H H    . GLY A 1 15  ? -7.63964  -42.15457 18.16153  1.000 43.05140  ? 15  GLY A H    1 
ATOM   224  H HA2  . GLY A 1 15  ? -7.13121  -44.03442 16.48253  1.000 47.96675  ? 15  GLY A HA2  1 
ATOM   225  H HA3  . GLY A 1 15  ? -8.05680  -44.18287 17.75363  1.000 47.96675  ? 15  GLY A HA3  1 
ATOM   226  N N    . CYS A 1 16  ? -9.83572  -42.75865 15.78260  1.000 35.34590  ? 16  CYS A N    1 
ATOM   227  C CA   . CYS A 1 16  ? -11.05320 -42.80707 14.98100  1.000 34.54991  ? 16  CYS A CA   1 
ATOM   228  C C    . CYS A 1 16  ? -10.90580 -42.16840 13.60729  1.000 34.73949  ? 16  CYS A C    1 
ATOM   229  O O    . CYS A 1 16  ? -11.81970 -42.29040 12.78453  1.000 36.14987  ? 16  CYS A O    1 
ATOM   230  C CB   . CYS A 1 16  ? -12.20605 -42.11213 15.72246  1.000 35.14111  ? 16  CYS A CB   1 
ATOM   231  S SG   . CYS A 1 16  ? -12.70573 -42.90815 17.26232  1.000 41.35861  ? 16  CYS A SG   1 
ATOM   232  H H    . CYS A 1 16  ? -9.63801  -41.97013 16.06321  1.000 43.15115  ? 16  CYS A H    1 
ATOM   233  H HA   . CYS A 1 16  ? -11.29243 -43.73819 14.85179  1.000 42.19596  ? 16  CYS A HA   1 
ATOM   234  H HB2  . CYS A 1 16  ? -11.93186 -41.20694 15.93773  1.000 42.90540  ? 16  CYS A HB2  1 
ATOM   235  H HB3  . CYS A 1 16  ? -12.98057 -42.09422 15.13876  1.000 42.90540  ? 16  CYS A HB3  1 
ATOM   236  H HG   . CYS A 1 16  ? -11.76198 -42.95507 18.00201  1.000 50.36640  ? 16  CYS A HG   1 
ATOM   237  N N    . MET A 1 17  ? -9.79672  -41.48994 13.33955  1.000 35.15178  ? 17  MET A N    1 
ATOM   238  C CA   . MET A 1 17  ? -9.63824  -40.77498 12.08306  1.000 36.69117  ? 17  MET A CA   1 
ATOM   239  C C    . MET A 1 17  ? -9.17152  -41.73313 10.99579  1.000 40.97483  ? 17  MET A C    1 
ATOM   240  O O    . MET A 1 17  ? -8.21442  -42.49086 11.18794  1.000 43.43972  ? 17  MET A O    1 
ATOM   241  C CB   . MET A 1 17  ? -8.64843  -39.62565 12.24808  1.000 36.22760  ? 17  MET A CB   1 
ATOM   242  C CG   . MET A 1 17  ? -9.05587  -38.61458 13.31337  1.000 31.30512  ? 17  MET A CG   1 
ATOM   243  S SD   . MET A 1 17  ? -10.76979 -38.05924 13.16076  1.000 28.53542  ? 17  MET A SD   1 
ATOM   244  C CE   . MET A 1 17  ? -10.76824 -37.40706 11.49271  1.000 30.61140  ? 17  MET A CE   1 
ATOM   245  H H    . MET A 1 17  ? -9.12226  -41.42886 13.86962  1.000 42.91820  ? 17  MET A H    1 
ATOM   246  H HA   . MET A 1 17  ? -10.49095 -40.39401 11.82106  1.000 44.76547  ? 17  MET A HA   1 
ATOM   247  H HB2  . MET A 1 17  ? -7.78578  -39.99054 12.50024  1.000 44.20919  ? 17  MET A HB2  1 
ATOM   248  H HB3  . MET A 1 17  ? -8.57499  -39.15347 11.40395  1.000 44.20919  ? 17  MET A HB3  1 
ATOM   249  H HG2  . MET A 1 17  ? -8.95235  -39.02171 14.18769  1.000 38.30221  ? 17  MET A HG2  1 
ATOM   250  H HG3  . MET A 1 17  ? -8.48346  -37.83487 13.24061  1.000 38.30221  ? 17  MET A HG3  1 
ATOM   251  H HE1  . MET A 1 17  ? -11.61312 -36.96005 11.32762  1.000 37.46974  ? 17  MET A HE1  1 
ATOM   252  H HE2  . MET A 1 17  ? -10.03691 -36.77648 11.40085  1.000 37.46974  ? 17  MET A HE2  1 
ATOM   253  H HE3  . MET A 1 17  ? -10.65386 -38.13964 10.86730  1.000 37.46974  ? 17  MET A HE3  1 
ATOM   254  N N    . VAL A 1 18  ? -9.86083  -41.70226 9.85546   1.000 41.89454  ? 18  VAL A N    1 
ATOM   255  C CA   . VAL A 1 18  ? -9.53543  -42.54190 8.71350   1.000 46.86218  ? 18  VAL A CA   1 
ATOM   256  C C    . VAL A 1 18  ? -9.50498  -41.67428 7.46281   1.000 45.06711  ? 18  VAL A C    1 
ATOM   257  O O    . VAL A 1 18  ? -10.04584 -40.56754 7.42785   1.000 43.88579  ? 18  VAL A O    1 
ATOM   258  C CB   . VAL A 1 18  ? -10.53440 -43.70673 8.53295   1.000 47.39493  ? 18  VAL A CB   1 
ATOM   259  C CG1  . VAL A 1 18  ? -10.55238 -44.58213 9.77591   1.000 47.59066  ? 18  VAL A CG1  1 
ATOM   260  C CG2  . VAL A 1 18  ? -11.92884 -43.18006 8.22239   1.000 44.45625  ? 18  VAL A CG2  1 
ATOM   261  H H    . VAL A 1 18  ? -10.53737 -41.18888 9.72008   1.000 51.00951  ? 18  VAL A H    1 
ATOM   262  H HA   . VAL A 1 18  ? -8.65225  -42.92142 8.84332   1.000 56.97068  ? 18  VAL A HA   1 
ATOM   263  H HB   . VAL A 1 18  ? -10.25009 -44.25043 7.78164   1.000 57.60999  ? 18  VAL A HB   1 
ATOM   264  H HG11 . VAL A 1 18  ? -11.14051 -45.33786 9.62144   1.000 57.84486  ? 18  VAL A HG11 1 
ATOM   265  H HG12 . VAL A 1 18  ? -9.65183  -44.89498 9.95489   1.000 57.84486  ? 18  VAL A HG12 1 
ATOM   266  H HG13 . VAL A 1 18  ? -10.87600 -44.05902 10.52594  1.000 57.84486  ? 18  VAL A HG13 1 
ATOM   267  H HG21 . VAL A 1 18  ? -12.54889 -43.92547 8.19409   1.000 54.08357  ? 18  VAL A HG21 1 
ATOM   268  H HG22 . VAL A 1 18  ? -12.19279 -42.55643 8.91687   1.000 54.08357  ? 18  VAL A HG22 1 
ATOM   269  H HG23 . VAL A 1 18  ? -11.91250 -42.73059 7.36297   1.000 54.08357  ? 18  VAL A HG23 1 
ATOM   270  N N    . GLN A 1 19  ? -8.85993  -42.20161 6.42836   1.000 50.68547  ? 19  GLN A N    1 
ATOM   271  C CA   . GLN A 1 19  ? -8.73677  -41.53876 5.13634   1.000 51.85831  ? 19  GLN A CA   1 
ATOM   272  C C    . GLN A 1 19  ? -9.81712  -42.08071 4.21078   1.000 51.96053  ? 19  GLN A C    1 
ATOM   273  O O    . GLN A 1 19  ? -9.88710  -43.29159 3.97888   1.000 55.44997  ? 19  GLN A O    1 
ATOM   274  C CB   . GLN A 1 19  ? -7.34360  -41.77535 4.55429   1.000 56.22110  ? 19  GLN A CB   1 
ATOM   275  C CG   . GLN A 1 19  ? -7.08475  -41.12982 3.20743   1.000 58.38239  ? 19  GLN A CG   1 
ATOM   276  C CD   . GLN A 1 19  ? -5.65014  -41.33205 2.74270   1.000 63.44195  ? 19  GLN A CD   1 
ATOM   277  O OE1  . GLN A 1 19  ? -4.81587  -41.85986 3.47851   1.000 72.01370  ? 19  GLN A OE1  1 
ATOM   278  N NE2  . GLN A 1 19  ? -5.35886  -40.91134 1.51757   1.000 64.81895  ? 19  GLN A NE2  1 
ATOM   279  H H    . GLN A 1 19  ? -8.47210  -42.96884 6.45173   1.000 61.55863  ? 19  GLN A H    1 
ATOM   280  H HA   . GLN A 1 19  ? -8.86930  -40.58255 5.23116   1.000 62.96604  ? 19  GLN A HA   1 
ATOM   281  H HB2  . GLN A 1 19  ? -6.68854  -41.42087 5.17570   1.000 68.20139  ? 19  GLN A HB2  1 
ATOM   282  H HB3  . GLN A 1 19  ? -7.21562  -42.73082 4.44656   1.000 68.20139  ? 19  GLN A HB3  1 
ATOM   283  H HG2  . GLN A 1 19  ? -7.67553  -41.52354 2.54647   1.000 70.79493  ? 19  GLN A HG2  1 
ATOM   284  H HG3  . GLN A 1 19  ? -7.24995  -40.17631 3.27398   1.000 70.79493  ? 19  GLN A HG3  1 
ATOM   285  H HE21 . GLN A 1 19  ? -5.96783  -40.54665 1.03202   1.000 78.51881  ? 19  GLN A HE21 1 
ATOM   286  H HE22 . GLN A 1 19  ? -4.56122  -41.00352 1.20956   1.000 78.51881  ? 19  GLN A HE22 1 
ATOM   287  N N    . VAL A 1 20  ? -10.66366 -41.19247 3.69893   1.000 49.57743  ? 20  VAL A N    1 
ATOM   288  C CA   . VAL A 1 20  ? -11.74635 -41.56152 2.79437   1.000 51.54482  ? 20  VAL A CA   1 
ATOM   289  C C    . VAL A 1 20  ? -11.42798 -40.99386 1.41940   1.000 51.54663  ? 20  VAL A C    1 
ATOM   290  O O    . VAL A 1 20  ? -11.02194 -39.83160 1.29692   1.000 48.55119  ? 20  VAL A O    1 
ATOM   291  C CB   . VAL A 1 20  ? -13.10889 -41.06047 3.30018   1.000 47.15229  ? 20  VAL A CB   1 
ATOM   292  C CG1  . VAL A 1 20  ? -14.19978 -41.40642 2.29825   1.000 47.34142  ? 20  VAL A CG1  1 
ATOM   293  C CG2  . VAL A 1 20  ? -13.42302 -41.66376 4.65847   1.000 48.16158  ? 20  VAL A CG2  1 
ATOM   294  H H    . VAL A 1 20  ? -10.62921 -40.34951 3.86574   1.000 60.22899  ? 20  VAL A H    1 
ATOM   295  H HA   . VAL A 1 20  ? -11.79098 -42.52806 2.72574   1.000 62.58985  ? 20  VAL A HA   1 
ATOM   296  H HB   . VAL A 1 20  ? -13.07687 -40.09587 3.39720   1.000 57.31881  ? 20  VAL A HB   1 
ATOM   297  H HG11 . VAL A 1 20  ? -15.05519 -41.42146 2.75536   1.000 57.54577  ? 20  VAL A HG11 1 
ATOM   298  H HG12 . VAL A 1 20  ? -14.21043 -40.73475 1.59850   1.000 57.54577  ? 20  VAL A HG12 1 
ATOM   299  H HG13 . VAL A 1 20  ? -14.01320 -42.27854 1.91681   1.000 57.54577  ? 20  VAL A HG13 1 
ATOM   300  H HG21 . VAL A 1 20  ? -14.28187 -41.32979 4.96137   1.000 58.52997  ? 20  VAL A HG21 1 
ATOM   301  H HG22 . VAL A 1 20  ? -13.45435 -42.62969 4.57539   1.000 58.52997  ? 20  VAL A HG22 1 
ATOM   302  H HG23 . VAL A 1 20  ? -12.72876 -41.40806 5.28579   1.000 58.52997  ? 20  VAL A HG23 1 
ATOM   303  N N    . THR A 1 21  ? -11.60730 -41.81450 0.38841   1.000 53.56252  ? 21  THR A N    1 
ATOM   304  C CA   . THR A 1 21  ? -11.21090 -41.45784 -0.97013  1.000 52.76802  ? 21  THR A CA   1 
ATOM   305  C C    . THR A 1 21  ? -12.25307 -42.01012 -1.93119  1.000 55.18379  ? 21  THR A C    1 
ATOM   306  O O    . THR A 1 21  ? -12.36892 -43.22798 -2.09633  1.000 57.98804  ? 21  THR A O    1 
ATOM   307  C CB   . THR A 1 21  ? -9.81675  -41.99919 -1.29222  1.000 54.23759  ? 21  THR A CB   1 
ATOM   308  O OG1  . THR A 1 21  ? -8.87921  -41.50264 -0.32648  1.000 55.79897  ? 21  THR A OG1  1 
ATOM   309  C CG2  . THR A 1 21  ? -9.37499  -41.57546 -2.68467  1.000 56.48263  ? 21  THR A CG2  1 
ATOM   310  H H    . THR A 1 21  ? -11.96201 -42.59540 0.45155   1.000 65.01110  ? 21  THR A H    1 
ATOM   311  H HA   . THR A 1 21  ? -11.19637 -40.49254 -1.06442  1.000 64.05770  ? 21  THR A HA   1 
ATOM   312  H HB   . THR A 1 21  ? -9.83532  -42.96864 -1.26518  1.000 65.82117  ? 21  THR A HB   1 
ATOM   313  H HG1  . THR A 1 21  ? -9.05879  -40.70455 -0.13570  1.000 67.69483  ? 21  THR A HG1  1 
ATOM   314  H HG21 . THR A 1 21  ? -8.40663  -41.57913 -2.74097  1.000 68.51523  ? 21  THR A HG21 1 
ATOM   315  H HG22 . THR A 1 21  ? -9.73113  -42.18854 -3.34663  1.000 68.51523  ? 21  THR A HG22 1 
ATOM   316  H HG23 . THR A 1 21  ? -9.69814  -40.68143 -2.87753  1.000 68.51523  ? 21  THR A HG23 1 
ATOM   317  N N    . CYS A 1 22  ? -13.02751 -41.11397 -2.53378  1.000 56.15893  ? 22  CYS A N    1 
ATOM   318  C CA   . CYS A 1 22  ? -13.93914 -41.43397 -3.62352  1.000 56.31213  ? 22  CYS A CA   1 
ATOM   319  C C    . CYS A 1 22  ? -13.38991 -40.75821 -4.87282  1.000 58.94715  ? 22  CYS A C    1 
ATOM   320  O O    . CYS A 1 22  ? -13.17200 -39.54167 -4.87685  1.000 59.39660  ? 22  CYS A O    1 
ATOM   321  C CB   . CYS A 1 22  ? -15.35710 -40.95811 -3.31837  1.000 54.48530  ? 22  CYS A CB   1 
ATOM   322  S SG   . CYS A 1 22  ? -16.63440 -41.66255 -4.39867  1.000 57.30731  ? 22  CYS A SG   1 
ATOM   323  H H    . CYS A 1 22  ? -13.04196 -40.28128 -2.31926  1.000 68.12678  ? 22  CYS A H    1 
ATOM   324  H HA   . CYS A 1 22  ? -13.98275 -42.39262 -3.76490  1.000 68.31063  ? 22  CYS A HA   1 
ATOM   325  H HB2  . CYS A 1 22  ? -15.57610 -41.20429 -2.40604  1.000 66.11843  ? 22  CYS A HB2  1 
ATOM   326  H HB3  . CYS A 1 22  ? -15.38766 -39.99374 -3.41822  1.000 66.11843  ? 22  CYS A HB3  1 
ATOM   327  H HG   . CYS A 1 22  ? -17.67976 -41.11763 -4.17445  1.000 69.50484  ? 22  CYS A HG   1 
ATOM   328  N N    . GLY A 1 23  ? -13.14390 -41.54471 -5.91429  1.000 60.15209  ? 23  GLY A N    1 
ATOM   329  C CA   . GLY A 1 23  ? -12.55614 -40.98786 -7.12281  1.000 60.60155  ? 23  GLY A CA   1 
ATOM   330  C C    . GLY A 1 23  ? -11.21980 -40.33580 -6.83048  1.000 60.61852  ? 23  GLY A C    1 
ATOM   331  O O    . GLY A 1 23  ? -10.33061 -40.93513 -6.21583  1.000 60.59874  ? 23  GLY A O    1 
ATOM   332  H H    . GLY A 1 23  ? -13.30499 -42.38888 -5.94636  1.000 72.91858  ? 23  GLY A H    1 
ATOM   333  H HA2  . GLY A 1 23  ? -12.42147 -41.69310 -7.77503  1.000 73.45792  ? 23  GLY A HA2  1 
ATOM   334  H HA3  . GLY A 1 23  ? -13.15188 -40.32048 -7.49779  1.000 73.45792  ? 23  GLY A HA3  1 
ATOM   335  N N    . THR A 1 24  ? -11.07319 -39.08269 -7.27054  1.000 61.78551  ? 24  THR A N    1 
ATOM   336  C CA   . THR A 1 24  ? -9.84131  -38.34363 -7.02269  1.000 63.34427  ? 24  THR A CA   1 
ATOM   337  C C    . THR A 1 24  ? -9.83932  -37.66805 -5.65685  1.000 62.74245  ? 24  THR A C    1 
ATOM   338  O O    . THR A 1 24  ? -8.76745  -37.41718 -5.09450  1.000 62.41892  ? 24  THR A O    1 
ATOM   339  C CB   . THR A 1 24  ? -9.63231  -37.27539 -8.09969  1.000 66.81542  ? 24  THR A CB   1 
ATOM   340  O OG1  . THR A 1 24  ? -8.31787  -36.71554 -7.98128  1.000 68.67668  ? 24  THR A OG1  1 
ATOM   341  C CG2  . THR A 1 24  ? -10.66031 -36.15605 -7.94604  1.000 70.52225  ? 24  THR A CG2  1 
ATOM   342  H H    . THR A 1 24  ? -11.66831 -38.64479 -7.71063  1.000 74.87867  ? 24  THR A H    1 
ATOM   343  H HA   . THR A 1 24  ? -9.10404  -38.97277 -7.06162  1.000 76.74920  ? 24  THR A HA   1 
ATOM   344  H HB   . THR A 1 24  ? -9.73609  -37.67998 -8.97516  1.000 80.91457  ? 24  THR A HB   1 
ATOM   345  H HG1  . THR A 1 24  ? -8.16880  -36.19415 -8.62279  1.000 83.14809  ? 24  THR A HG1  1 
ATOM   346  H HG21 . THR A 1 24  ? -10.74437 -35.66618 -8.77902  1.000 85.36277  ? 24  THR A HG21 1 
ATOM   347  H HG22 . THR A 1 24  ? -11.52447 -36.52913 -7.71166  1.000 85.36277  ? 24  THR A HG22 1 
ATOM   348  H HG23 . THR A 1 24  ? -10.38189 -35.54353 -7.24734  1.000 85.36277  ? 24  THR A HG23 1 
ATOM   349  N N    . THR A 1 25  ? -11.01512 -37.35866 -5.11801  1.000 61.72882  ? 25  THR A N    1 
ATOM   350  C CA   . THR A 1 25  ? -11.11142 -36.57273 -3.89536  1.000 60.39601  ? 25  THR A CA   1 
ATOM   351  C C    . THR A 1 25  ? -10.77376 -37.43364 -2.68495  1.000 55.10535  ? 25  THR A C    1 
ATOM   352  O O    . THR A 1 25  ? -11.23669 -38.57231 -2.57314  1.000 53.44105  ? 25  THR A O    1 
ATOM   353  C CB   . THR A 1 25  ? -12.51825 -35.98830 -3.75614  1.000 64.11323  ? 25  THR A CB   1 
ATOM   354  O OG1  . THR A 1 25  ? -12.88779 -35.33244 -4.97715  1.000 63.81044  ? 25  THR A OG1  1 
ATOM   355  C CG2  . THR A 1 25  ? -12.57905 -34.98972 -2.60705  1.000 54.76927  ? 25  THR A CG2  1 
ATOM   356  H H    . THR A 1 25  ? -11.77537 -37.59387 -5.44403  1.000 74.81065  ? 25  THR A H    1 
ATOM   357  H HA   . THR A 1 25  ? -10.47577 -35.84088 -3.93080  1.000 73.21128  ? 25  THR A HA   1 
ATOM   358  H HB   . THR A 1 25  ? -13.14608 -36.70342 -3.56814  1.000 77.67194  ? 25  THR A HB   1 
ATOM   359  H HG1  . THR A 1 25  ? -13.65981 -35.56942 -5.20830  1.000 77.30859  ? 25  THR A HG1  1 
ATOM   360  H HG21 . THR A 1 25  ? -13.41023 -34.49109 -2.64447  1.000 66.45919  ? 25  THR A HG21 1 
ATOM   361  H HG22 . THR A 1 25  ? -12.53024 -35.45707 -1.75846  1.000 66.45919  ? 25  THR A HG22 1 
ATOM   362  H HG23 . THR A 1 25  ? -11.83639 -34.36868 -2.66757  1.000 66.45919  ? 25  THR A HG23 1 
ATOM   363  N N    . THR A 1 26  ? -9.95930  -36.88826 -1.78345  1.000 54.05728  ? 26  THR A N    1 
ATOM   364  C CA   . THR A 1 26  ? -9.61202  -37.54481 -0.52836  1.000 51.39657  ? 26  THR A CA   1 
ATOM   365  C C    . THR A 1 26  ? -9.82225  -36.56135 0.61347   1.000 46.12686  ? 26  THR A C    1 
ATOM   366  O O    . THR A 1 26  ? -9.30997  -35.43825 0.57146   1.000 46.84310  ? 26  THR A O    1 
ATOM   367  C CB   . THR A 1 26  ? -8.15891  -38.04755 -0.54011  1.000 53.41587  ? 26  THR A CB   1 
ATOM   368  O OG1  . THR A 1 26  ? -8.08402  -39.29772 -1.23623  1.000 52.03148  ? 26  THR A OG1  1 
ATOM   369  C CG2  . THR A 1 26  ? -7.63004  -38.22432 0.87923   1.000 52.54852  ? 26  THR A CG2  1 
ATOM   370  H H    . THR A 1 26  ? -9.58692  -36.11913 -1.88030  1.000 65.60480  ? 26  THR A H    1 
ATOM   371  H HA   . THR A 1 26  ? -10.19240 -38.30946 -0.38919  1.000 62.41195  ? 26  THR A HA   1 
ATOM   372  H HB   . THR A 1 26  ? -7.60090  -37.39377 -0.98967  1.000 64.83511  ? 26  THR A HB   1 
ATOM   373  H HG1  . THR A 1 26  ? -7.28232  -39.53670 -1.31217  1.000 63.17384  ? 26  THR A HG1  1 
ATOM   374  H HG21 . THR A 1 26  ? -6.78352  -38.69759 0.86130   1.000 63.79429  ? 26  THR A HG21 1 
ATOM   375  H HG22 . THR A 1 26  ? -7.49743  -37.35765 1.29420   1.000 63.79429  ? 26  THR A HG22 1 
ATOM   376  H HG23 . THR A 1 26  ? -8.26399  -38.73308 1.40853   1.000 63.79429  ? 26  THR A HG23 1 
ATOM   377  N N    . LEU A 1 27  ? -10.57085 -36.98298 1.63071   1.000 45.25091  ? 27  LEU A N    1 
ATOM   378  C CA   . LEU A 1 27  ? -10.76004 -36.18162 2.83044   1.000 44.08906  ? 27  LEU A CA   1 
ATOM   379  C C    . LEU A 1 27  ? -10.82811 -37.10814 4.03815   1.000 43.72240  ? 27  LEU A C    1 
ATOM   380  O O    . LEU A 1 27  ? -10.76344 -38.33604 3.91624   1.000 44.12673  ? 27  LEU A O    1 
ATOM   381  C CB   . LEU A 1 27  ? -12.00620 -35.29610 2.71761   1.000 38.01922  ? 27  LEU A CB   1 
ATOM   382  C CG   . LEU A 1 27  ? -13.30009 -35.89493 2.16497   1.000 38.01798  ? 27  LEU A CG   1 
ATOM   383  C CD1  . LEU A 1 27  ? -13.82053 -37.00248 3.06216   1.000 40.57777  ? 27  LEU A CD1  1 
ATOM   384  C CD2  . LEU A 1 27  ? -14.34462 -34.78773 1.98619   1.000 37.12515  ? 27  LEU A CD2  1 
ATOM   385  H H    . LEU A 1 27  ? -10.98231 -37.73800 1.64656   1.000 55.03716  ? 27  LEU A H    1 
ATOM   386  H HA   . LEU A 1 27  ? -9.99201  -35.60062 2.94645   1.000 53.64294  ? 27  LEU A HA   1 
ATOM   387  H HB2  . LEU A 1 27  ? -12.21345 -34.97288 3.60838   1.000 46.35913  ? 27  LEU A HB2  1 
ATOM   388  H HB3  . LEU A 1 27  ? -11.78078 -34.55129 2.13853   1.000 46.35913  ? 27  LEU A HB3  1 
ATOM   389  H HG   . LEU A 1 27  ? -13.12504 -36.29524 1.29893   1.000 46.35764  ? 27  LEU A HG   1 
ATOM   390  H HD11 . LEU A 1 27  ? -14.73926 -37.19892 2.82082   1.000 49.42939  ? 27  LEU A HD11 1 
ATOM   391  H HD12 . LEU A 1 27  ? -13.27050 -37.79214 2.94052   1.000 49.42939  ? 27  LEU A HD12 1 
ATOM   392  H HD13 . LEU A 1 27  ? -13.77678 -36.70789 3.98530   1.000 49.42939  ? 27  LEU A HD13 1 
ATOM   393  H HD21 . LEU A 1 27  ? -15.23099 -35.17773 2.04232   1.000 45.28624  ? 27  LEU A HD21 1 
ATOM   394  H HD22 . LEU A 1 27  ? -14.22856 -34.12785 2.68760   1.000 45.28624  ? 27  LEU A HD22 1 
ATOM   395  H HD23 . LEU A 1 27  ? -14.22000 -34.37319 1.11813   1.000 45.28624  ? 27  LEU A HD23 1 
ATOM   396  N N    . ASN A 1 28  ? -10.94954 -36.51471 5.22018   1.000 39.58966  ? 28  ASN A N    1 
ATOM   397  C CA   . ASN A 1 28  ? -10.94135 -37.27466 6.45957   1.000 38.23615  ? 28  ASN A CA   1 
ATOM   398  C C    . ASN A 1 28  ? -12.32919 -37.80673 6.78699   1.000 36.98250  ? 28  ASN A C    1 
ATOM   399  O O    . ASN A 1 28  ? -13.34728 -37.16762 6.50484   1.000 36.93694  ? 28  ASN A O    1 
ATOM   400  C CB   . ASN A 1 28  ? -10.43821 -36.42786 7.63124   1.000 38.13284  ? 28  ASN A CB   1 
ATOM   401  C CG   . ASN A 1 28  ? -9.05049  -35.88898 7.39903   1.000 38.91941  ? 28  ASN A CG   1 
ATOM   402  O OD1  . ASN A 1 28  ? -8.07136  -36.63290 7.42401   1.000 43.33806  ? 28  ASN A OD1  1 
ATOM   403  N ND2  . ASN A 1 28  ? -8.95276  -34.58253 7.18208   1.000 36.15847  ? 28  ASN A ND2  1 
ATOM   404  H H    . ASN A 1 28  ? -11.03857 -35.66634 5.32945   1.000 48.24366  ? 28  ASN A H    1 
ATOM   405  H HA   . ASN A 1 28  ? -10.34098 -38.02827 6.34769   1.000 46.61944  ? 28  ASN A HA   1 
ATOM   406  H HB2  . ASN A 1 28  ? -11.03628 -35.67478 7.75805   1.000 46.49547  ? 28  ASN A HB2  1 
ATOM   407  H HB3  . ASN A 1 28  ? -10.41872 -36.97458 8.43225   1.000 46.49547  ? 28  ASN A HB3  1 
ATOM   408  H HD21 . ASN A 1 28  ? -8.18241  -34.22599 7.04410   1.000 44.12623  ? 28  ASN A HD21 1 
ATOM   409  H HD22 . ASN A 1 28  ? -9.65983  -34.09299 7.17955   1.000 44.12623  ? 28  ASN A HD22 1 
ATOM   410  N N    . GLY A 1 29  ? -12.35163 -38.99186 7.39480   1.000 35.78693  ? 29  GLY A N    1 
ATOM   411  C CA   . GLY A 1 29  ? -13.58002 -39.56785 7.87808   1.000 34.82134  ? 29  GLY A CA   1 
ATOM   412  C C    . GLY A 1 29  ? -13.42381 -39.97507 9.33101   1.000 33.88275  ? 29  GLY A C    1 
ATOM   413  O O    . GLY A 1 29  ? -12.32245 -40.06460 9.85950   1.000 34.59071  ? 29  GLY A O    1 
ATOM   414  H H    . GLY A 1 29  ? -11.65669 -39.47848 7.53571   1.000 43.68038  ? 29  GLY A H    1 
ATOM   415  H HA2  . GLY A 1 29  ? -14.29927 -38.92090 7.80710   1.000 42.52167  ? 29  GLY A HA2  1 
ATOM   416  H HA3  . GLY A 1 29  ? -13.80709 -40.35137 7.35326   1.000 42.52167  ? 29  GLY A HA3  1 
ATOM   417  N N    . LEU A 1 30  ? -14.56554 -40.21416 9.96689   1.000 33.78086  ? 30  LEU A N    1 
ATOM   418  C CA   . LEU A 1 30  ? -14.62774 -40.56326 11.38138  1.000 33.53256  ? 30  LEU A CA   1 
ATOM   419  C C    . LEU A 1 30  ? -15.21881 -41.95882 11.51276  1.000 36.23279  ? 30  LEU A C    1 
ATOM   420  O O    . LEU A 1 30  ? -16.39177 -42.16957 11.19122  1.000 37.37667  ? 30  LEU A O    1 
ATOM   421  C CB   . LEU A 1 30  ? -15.46298 -39.54662 12.16021  1.000 31.29310  ? 30  LEU A CB   1 
ATOM   422  C CG   . LEU A 1 30  ? -15.59356 -39.80917 13.65937  1.000 32.23873  ? 30  LEU A CG   1 
ATOM   423  C CD1  . LEU A 1 30  ? -14.28323 -39.51995 14.37721  1.000 32.12056  ? 30  LEU A CD1  1 
ATOM   424  C CD2  . LEU A 1 30  ? -16.72365 -38.98361 14.25120  1.000 30.84730  ? 30  LEU A CD2  1 
ATOM   425  H H    . LEU A 1 30  ? -15.33765 -40.17926 9.58977   1.000 41.27310  ? 30  LEU A H    1 
ATOM   426  H HA   . LEU A 1 30  ? -13.73255 -40.57310 11.75477  1.000 40.97514  ? 30  LEU A HA   1 
ATOM   427  H HB2  . LEU A 1 30  ? -15.05471 -38.67311 12.05443  1.000 38.28779  ? 30  LEU A HB2  1 
ATOM   428  H HB3  . LEU A 1 30  ? -16.35904 -39.54120 11.78879  1.000 38.28779  ? 30  LEU A HB3  1 
ATOM   429  H HG   . LEU A 1 30  ? -15.80404 -40.74645 13.79393  1.000 39.42255  ? 30  LEU A HG   1 
ATOM   430  H HD11 . LEU A 1 30  ? -14.40265 -39.67518 15.32723  1.000 39.28074  ? 30  LEU A HD11 1 
ATOM   431  H HD12 . LEU A 1 30  ? -13.59587 -40.10950 14.02954  1.000 39.28074  ? 30  LEU A HD12 1 
ATOM   432  H HD13 . LEU A 1 30  ? -14.03542 -38.59511 14.22174  1.000 39.28074  ? 30  LEU A HD13 1 
ATOM   433  H HD21 . LEU A 1 30  ? -16.71091 -39.07700 15.21661  1.000 37.75283  ? 30  LEU A HD21 1 
ATOM   434  H HD22 . LEU A 1 30  ? -16.59659 -38.05346 14.00714  1.000 37.75283  ? 30  LEU A HD22 1 
ATOM   435  H HD23 . LEU A 1 30  ? -17.56807 -39.30566 13.89884  1.000 37.75283  ? 30  LEU A HD23 1 
ATOM   436  N N    . TRP A 1 31  ? -14.41223 -42.90023 11.99965  1.000 39.03997  ? 31  TRP A N    1 
ATOM   437  C CA   . TRP A 1 31  ? -14.76589 -44.31350 12.03844  1.000 40.10396  ? 31  TRP A CA   1 
ATOM   438  C C    . TRP A 1 31  ? -15.20213 -44.68529 13.45032  1.000 38.75695  ? 31  TRP A C    1 
ATOM   439  O O    . TRP A 1 31  ? -14.36736 -44.77211 14.35950  1.000 38.93567  ? 31  TRP A O    1 
ATOM   440  C CB   . TRP A 1 31  ? -13.57083 -45.15025 11.57293  1.000 43.71343  ? 31  TRP A CB   1 
ATOM   441  C CG   . TRP A 1 31  ? -13.75760 -46.63475 11.60039  1.000 47.91511  ? 31  TRP A CG   1 
ATOM   442  C CD1  . TRP A 1 31  ? -14.93668 -47.31807 11.63083  1.000 49.41475  ? 31  TRP A CD1  1 
ATOM   443  C CD2  . TRP A 1 31  ? -12.71848 -47.62487 11.60299  1.000 52.52280  ? 31  TRP A CD2  1 
ATOM   444  N NE1  . TRP A 1 31  ? -14.69759 -48.67253 11.65605  1.000 50.92107  ? 31  TRP A NE1  1 
ATOM   445  C CE2  . TRP A 1 31  ? -13.34414 -48.88654 11.63720  1.000 53.54958  ? 31  TRP A CE2  1 
ATOM   446  C CE3  . TRP A 1 31  ? -11.32099 -47.56501 11.58152  1.000 60.70548  ? 31  TRP A CE3  1 
ATOM   447  C CZ2  . TRP A 1 31  ? -12.62186 -50.07856 11.65455  1.000 55.88046  ? 31  TRP A CZ2  1 
ATOM   448  C CZ3  . TRP A 1 31  ? -10.60460 -48.74926 11.59634  1.000 55.93131  ? 31  TRP A CZ3  1 
ATOM   449  C CH2  . TRP A 1 31  ? -11.25602 -49.98959 11.63215  1.000 56.97018  ? 31  TRP A CH2  1 
ATOM   450  H H    . TRP A 1 31  ? -13.63188 -42.73752 12.32239  1.000 47.58404  ? 31  TRP A H    1 
ATOM   451  H HA   . TRP A 1 31  ? -15.52097 -44.48428 11.45399  1.000 48.86082  ? 31  TRP A HA   1 
ATOM   452  H HB2  . TRP A 1 31  ? -13.36713 -44.90436 10.65699  1.000 53.19218  ? 31  TRP A HB2  1 
ATOM   453  H HB3  . TRP A 1 31  ? -12.81601 -44.94614 12.14693  1.000 53.19218  ? 31  TRP A HB3  1 
ATOM   454  H HD1  . TRP A 1 31  ? -15.77987 -46.92576 11.63407  1.000 60.03376  ? 31  TRP A HD1  1 
ATOM   455  H HE1  . TRP A 1 31  ? -15.30004 -49.28580 11.67981  1.000 61.84135  ? 31  TRP A HE1  1 
ATOM   456  H HE3  . TRP A 1 31  ? -10.88187 -46.74555 11.55775  1.000 73.58265  ? 31  TRP A HE3  1 
ATOM   457  H HZ2  . TRP A 1 31  ? -13.05152 -50.90295 11.68038  1.000 67.79263  ? 31  TRP A HZ2  1 
ATOM   458  H HZ3  . TRP A 1 31  ? -9.67512  -48.72138 11.58229  1.000 67.85364  ? 31  TRP A HZ3  1 
ATOM   459  H HH2  . TRP A 1 31  ? -10.74927 -50.76935 11.64088  1.000 69.10029  ? 31  TRP A HH2  1 
ATOM   460  N N    . LEU A 1 32  ? -16.50477 -44.89448 13.62851  1.000 39.81341  ? 32  LEU A N    1 
ATOM   461  C CA   . LEU A 1 32  ? -17.07461 -45.31583 14.89943  1.000 42.43504  ? 32  LEU A CA   1 
ATOM   462  C C    . LEU A 1 32  ? -17.89020 -46.58178 14.68291  1.000 44.88958  ? 32  LEU A C    1 
ATOM   463  O O    . LEU A 1 32  ? -18.67640 -46.66668 13.73233  1.000 44.17889  ? 32  LEU A O    1 
ATOM   464  C CB   . LEU A 1 32  ? -17.96128 -44.23078 15.49975  1.000 39.99216  ? 32  LEU A CB   1 
ATOM   465  C CG   . LEU A 1 32  ? -17.29457 -42.88446 15.75261  1.000 37.87700  ? 32  LEU A CG   1 
ATOM   466  C CD1  . LEU A 1 32  ? -18.35972 -41.82782 16.00993  1.000 35.57535  ? 32  LEU A CD1  1 
ATOM   467  C CD2  . LEU A 1 32  ? -16.32305 -42.96203 16.91499  1.000 38.31138  ? 32  LEU A CD2  1 
ATOM   468  H H    . LEU A 1 32  ? -17.09234 -44.79517 13.00842  1.000 48.51216  ? 32  LEU A H    1 
ATOM   469  H HA   . LEU A 1 32  ? -16.36194 -45.50361 15.53010  1.000 51.65811  ? 32  LEU A HA   1 
ATOM   470  H HB2  . LEU A 1 32  ? -18.70111 -44.07482 14.89211  1.000 48.72666  ? 32  LEU A HB2  1 
ATOM   471  H HB3  . LEU A 1 32  ? -18.29435 -44.55059 16.35280  1.000 48.72666  ? 32  LEU A HB3  1 
ATOM   472  H HG   . LEU A 1 32  ? -16.78282 -42.62956 14.96900  1.000 46.18847  ? 32  LEU A HG   1 
ATOM   473  H HD11 . LEU A 1 32  ? -17.92658 -40.97346 16.16275  1.000 43.42648  ? 32  LEU A HD11 1 
ATOM   474  H HD12 . LEU A 1 32  ? -18.94095 -41.77018 15.23550  1.000 43.42648  ? 32  LEU A HD12 1 
ATOM   475  H HD13 . LEU A 1 32  ? -18.87454 -42.08221 16.79169  1.000 43.42648  ? 32  LEU A HD13 1 
ATOM   476  H HD21 . LEU A 1 32  ? -15.95144 -42.08050 17.07535  1.000 46.70972  ? 32  LEU A HD21 1 
ATOM   477  H HD22 . LEU A 1 32  ? -16.79757 -43.26936 17.70320  1.000 46.70972  ? 32  LEU A HD22 1 
ATOM   478  H HD23 . LEU A 1 32  ? -15.61336 -43.58468 16.69240  1.000 46.70972  ? 32  LEU A HD23 1 
ATOM   479  N N    . ASP A 1 33  ? -17.71358 -47.55856 15.57139  1.000 45.08590  ? 33  ASP A N    1 
ATOM   480  C CA   . ASP A 1 33  ? -18.33550 -48.87661 15.40965  1.000 44.94699  ? 33  ASP A CA   1 
ATOM   481  C C    . ASP A 1 33  ? -18.04425 -49.31840 13.97405  1.000 48.41253  ? 33  ASP A C    1 
ATOM   482  O O    . ASP A 1 33  ? -16.88444 -49.24215 13.54454  1.000 49.20535  ? 33  ASP A O    1 
ATOM   483  C CB   . ASP A 1 33  ? -19.80609 -48.80011 15.79268  1.000 44.95812  ? 33  ASP A CB   1 
ATOM   484  C CG   . ASP A 1 33  ? -20.01143 -48.45638 17.24963  1.000 48.32556  ? 33  ASP A CG   1 
ATOM   485  O OD1  . ASP A 1 33  ? -19.13787 -48.79722 18.07557  1.000 48.51032  ? 33  ASP A OD1  1 
ATOM   486  O OD2  . ASP A 1 33  ? -21.05584 -47.84801 17.58062  1.000 48.04033  ? 33  ASP A OD2  1 
ATOM   487  H H    . ASP A 1 33  ? -17.23469 -47.48299 16.28171  1.000 54.83915  ? 33  ASP A H    1 
ATOM   488  H HA   . ASP A 1 33  ? -17.91291 -49.51097 16.00958  1.000 54.67246  ? 33  ASP A HA   1 
ATOM   489  H HB2  . ASP A 1 33  ? -20.23686 -48.11435 15.25876  1.000 54.68581  ? 33  ASP A HB2  1 
ATOM   490  H HB3  . ASP A 1 33  ? -20.22173 -49.66049 15.62567  1.000 54.68581  ? 33  ASP A HB3  1 
ATOM   491  N N    . ASP A 1 34  ? -19.03868 -49.75453 13.20064  1.000 50.61684  ? 34  ASP A N    1 
ATOM   492  C CA   . ASP A 1 34  ? -18.82939 -50.20877 11.83029  1.000 51.94717  ? 34  ASP A CA   1 
ATOM   493  C C    . ASP A 1 34  ? -19.37098 -49.20486 10.81744  1.000 54.33018  ? 34  ASP A C    1 
ATOM   494  O O    . ASP A 1 34  ? -19.95006 -49.58067 9.79751   1.000 55.71734  ? 34  ASP A O    1 
ATOM   495  C CB   . ASP A 1 34  ? -19.46324 -51.58352 11.61433  1.000 55.38460  ? 34  ASP A CB   1 
ATOM   496  C CG   . ASP A 1 34  ? -20.98172 -51.57499 11.77605  1.000 60.54766  ? 34  ASP A CG   1 
ATOM   497  O OD1  . ASP A 1 34  ? -21.54081 -50.54518 12.20521  1.000 59.17884  ? 34  ASP A OD1  1 
ATOM   498  O OD2  . ASP A 1 34  ? -21.60955 -52.61077 11.47297  1.000 64.13923  ? 34  ASP A OD2  1 
ATOM   499  H H    . ASP A 1 34  ? -19.85906 -49.79639 13.45526  1.000 61.47627  ? 34  ASP A H    1 
ATOM   500  H HA   . ASP A 1 34  ? -17.87491 -50.29217 11.67896  1.000 63.07267  ? 34  ASP A HA   1 
ATOM   501  H HB2  . ASP A 1 34  ? -19.26049 -51.88594 10.71525  1.000 67.19759  ? 34  ASP A HB2  1 
ATOM   502  H HB3  . ASP A 1 34  ? -19.09737 -52.20439 12.26361  1.000 67.19759  ? 34  ASP A HB3  1 
ATOM   503  N N    . VAL A 1 35  ? -19.17790 -47.91525 11.08442  1.000 50.05813  ? 35  VAL A N    1 
ATOM   504  C CA   . VAL A 1 35  ? -19.66654 -46.85605 10.21134  1.000 49.23815  ? 35  VAL A CA   1 
ATOM   505  C C    . VAL A 1 35  ? -18.60797 -45.76643 10.11717  1.000 45.57554  ? 35  VAL A C    1 
ATOM   506  O O    . VAL A 1 35  ? -17.93353 -45.45175 11.10360  1.000 44.24015  ? 35  VAL A O    1 
ATOM   507  C CB   . VAL A 1 35  ? -20.99889 -46.26164 10.71304  1.000 48.92188  ? 35  VAL A CB   1 
ATOM   508  C CG1  . VAL A 1 35  ? -21.42259 -45.10186 9.82048   1.000 46.28454  ? 35  VAL A CG1  1 
ATOM   509  C CG2  . VAL A 1 35  ? -22.07761 -47.32696 10.76202  1.000 53.15420  ? 35  VAL A CG2  1 
ATOM   510  H H    . VAL A 1 35  ? -18.75926 -47.62606 11.77776  1.000 60.80583  ? 35  VAL A H    1 
ATOM   511  H HA   . VAL A 1 35  ? -19.80844 -47.22784 9.32673   1.000 59.82185  ? 35  VAL A HA   1 
ATOM   512  H HB   . VAL A 1 35  ? -20.87636 -45.92499 11.61446  1.000 59.44233  ? 35  VAL A HB   1 
ATOM   513  H HG11 . VAL A 1 35  ? -22.35895 -44.90577 9.98070   1.000 56.27752  ? 35  VAL A HG11 1 
ATOM   514  H HG12 . VAL A 1 35  ? -20.88103 -44.32566 10.03292  1.000 56.27752  ? 35  VAL A HG12 1 
ATOM   515  H HG13 . VAL A 1 35  ? -21.29125 -45.35296 8.89279   1.000 56.27752  ? 35  VAL A HG13 1 
ATOM   516  H HG21 . VAL A 1 35  ? -22.92270 -46.91031 10.99255  1.000 64.52110  ? 35  VAL A HG21 1 
ATOM   517  H HG22 . VAL A 1 35  ? -22.14380 -47.74963 9.89146   1.000 64.52110  ? 35  VAL A HG22 1 
ATOM   518  H HG23 . VAL A 1 35  ? -21.84008 -47.98631 11.43265  1.000 64.52110  ? 35  VAL A HG23 1 
ATOM   519  N N    . VAL A 1 36  ? -18.48374 -45.17534 8.93232   1.000 43.54536  ? 36  VAL A N    1 
ATOM   520  C CA   . VAL A 1 36  ? -17.51184 -44.12395 8.65745   1.000 42.00536  ? 36  VAL A CA   1 
ATOM   521  C C    . VAL A 1 36  ? -18.27837 -42.88867 8.20527   1.000 43.78484  ? 36  VAL A C    1 
ATOM   522  O O    . VAL A 1 36  ? -19.05061 -42.95141 7.23944   1.000 45.47576  ? 36  VAL A O    1 
ATOM   523  C CB   . VAL A 1 36  ? -16.49267 -44.56620 7.59630   1.000 44.54338  ? 36  VAL A CB   1 
ATOM   524  C CG1  . VAL A 1 36  ? -15.61675 -43.40180 7.18235   1.000 41.55978  ? 36  VAL A CG1  1 
ATOM   525  C CG2  . VAL A 1 36  ? -15.64449 -45.71772 8.12539   1.000 48.40882  ? 36  VAL A CG2  1 
ATOM   526  H H    . VAL A 1 36  ? -18.96814 -45.37393 8.25004   1.000 52.99050  ? 36  VAL A H    1 
ATOM   527  H HA   . VAL A 1 36  ? -17.03092 -43.89979 9.46947   1.000 51.14250  ? 36  VAL A HA   1 
ATOM   528  H HB   . VAL A 1 36  ? -16.96939 -44.87621 6.81047   1.000 54.18812  ? 36  VAL A HB   1 
ATOM   529  H HG11 . VAL A 1 36  ? -14.86927 -43.73775 6.66340   1.000 50.60780  ? 36  VAL A HG11 1 
ATOM   530  H HG12 . VAL A 1 36  ? -16.14156 -42.78669 6.64651   1.000 50.60780  ? 36  VAL A HG12 1 
ATOM   531  H HG13 . VAL A 1 36  ? -15.29158 -42.95266 7.97824   1.000 50.60780  ? 36  VAL A HG13 1 
ATOM   532  H HG21 . VAL A 1 36  ? -15.09067 -46.05867 7.40571   1.000 58.82665  ? 36  VAL A HG21 1 
ATOM   533  H HG22 . VAL A 1 36  ? -15.08481 -45.39187 8.84753   1.000 58.82665  ? 36  VAL A HG22 1 
ATOM   534  H HG23 . VAL A 1 36  ? -16.23101 -46.41803 8.45166   1.000 58.82665  ? 36  VAL A HG23 1 
ATOM   535  N N    . TYR A 1 37  ? -18.06305 -41.77134 8.89897   1.000 38.81884  ? 37  TYR A N    1 
ATOM   536  C CA   . TYR A 1 37  ? -18.75773 -40.51595 8.63310   1.000 36.83725  ? 37  TYR A CA   1 
ATOM   537  C C    . TYR A 1 37  ? -17.79850 -39.53357 7.97313   1.000 34.90316  ? 37  TYR A C    1 
ATOM   538  O O    . TYR A 1 37  ? -16.68067 -39.33735 8.46389   1.000 36.20990  ? 37  TYR A O    1 
ATOM   539  C CB   . TYR A 1 37  ? -19.30552 -39.90796 9.92555   1.000 35.26887  ? 37  TYR A CB   1 
ATOM   540  C CG   . TYR A 1 37  ? -20.16665 -40.84556 10.73304  1.000 36.81758  ? 37  TYR A CG   1 
ATOM   541  C CD1  . TYR A 1 37  ? -19.59709 -41.83349 11.52419  1.000 37.34597  ? 37  TYR A CD1  1 
ATOM   542  C CD2  . TYR A 1 37  ? -21.54859 -40.74275 10.70699  1.000 37.65141  ? 37  TYR A CD2  1 
ATOM   543  C CE1  . TYR A 1 37  ? -20.37785 -42.69628 12.26107  1.000 37.54880  ? 37  TYR A CE1  1 
ATOM   544  C CE2  . TYR A 1 37  ? -22.34056 -41.59960 11.44301  1.000 39.19156  ? 37  TYR A CE2  1 
ATOM   545  C CZ   . TYR A 1 37  ? -21.75096 -42.57444 12.21784  1.000 39.22951  ? 37  TYR A CZ   1 
ATOM   546  O OH   . TYR A 1 37  ? -22.53520 -43.43497 12.95466  1.000 40.45057  ? 37  TYR A OH   1 
ATOM   547  H H    . TYR A 1 37  ? -17.50156 -41.71610 9.54803   1.000 47.31868  ? 37  TYR A H    1 
ATOM   548  H HA   . TYR A 1 37  ? -19.49782 -40.68302 8.02874   1.000 44.94077  ? 37  TYR A HA   1 
ATOM   549  H HB2  . TYR A 1 37  ? -18.55844 -39.64057 10.48348  1.000 43.05871  ? 37  TYR A HB2  1 
ATOM   550  H HB3  . TYR A 1 37  ? -19.84482 -39.13392 9.69993   1.000 43.05871  ? 37  TYR A HB3  1 
ATOM   551  H HD1  . TYR A 1 37  ? -18.67121 -41.91437 11.55736  1.000 45.55123  ? 37  TYR A HD1  1 
ATOM   552  H HD2  . TYR A 1 37  ? -21.94854 -40.08533 10.18475  1.000 45.91776  ? 37  TYR A HD2  1 
ATOM   553  H HE1  . TYR A 1 37  ? -19.98219 -43.35593 12.78376  1.000 45.79462  ? 37  TYR A HE1  1 
ATOM   554  H HE2  . TYR A 1 37  ? -23.26674 -41.51972 11.41634  1.000 47.76593  ? 37  TYR A HE2  1 
ATOM   555  H HH   . TYR A 1 37  ? -23.34562 -43.23290 12.86532  1.000 49.27675  ? 37  TYR A HH   1 
ATOM   556  N N    . CYS A 1 38  ? -18.24066 -38.89633 6.89663   1.000 35.59560  ? 38  CYS A N    1 
ATOM   557  C CA   . CYS A 1 38  ? -17.40251 -37.95699 6.16745   1.000 34.36088  ? 38  CYS A CA   1 
ATOM   558  C C    . CYS A 1 38  ? -18.28727 -36.97151 5.42909   1.000 32.13420  ? 38  CYS A C    1 
ATOM   559  O O    . CYS A 1 38  ? -19.48068 -37.22804 5.23728   1.000 33.21746  ? 38  CYS A O    1 
ATOM   560  C CB   . CYS A 1 38  ? -16.48277 -38.68637 5.18183   1.000 39.41664  ? 38  CYS A CB   1 
ATOM   561  S SG   . CYS A 1 38  ? -17.36363 -39.51983 3.83947   1.000 42.49385  ? 38  CYS A SG   1 
ATOM   562  H H    . CYS A 1 38  ? -19.02910 -38.99261 6.56696   1.000 43.45079  ? 38  CYS A H    1 
ATOM   563  H HA   . CYS A 1 38  ? -16.85802 -37.45705 6.79553   1.000 41.96912  ? 38  CYS A HA   1 
ATOM   564  H HB2  . CYS A 1 38  ? -15.87883 -38.04044 4.78318   1.000 48.03603  ? 38  CYS A HB2  1 
ATOM   565  H HB3  . CYS A 1 38  ? -15.97758 -39.35806 5.66609   1.000 48.03603  ? 38  CYS A HB3  1 
ATOM   566  H HG   . CYS A 1 38  ? -17.90523 -38.69518 3.15636   1.000 51.72868  ? 38  CYS A HG   1 
ATOM   567  N N    . PRO A 1 39  ? -17.73959 -35.82795 5.01319   1.000 33.18505  ? 39  PRO A N    1 
ATOM   568  C CA   . PRO A 1 39  ? -18.54043 -34.89010 4.21392   1.000 31.49052  ? 39  PRO A CA   1 
ATOM   569  C C    . PRO A 1 39  ? -19.00390 -35.53944 2.91956   1.000 36.06879  ? 39  PRO A C    1 
ATOM   570  O O    . PRO A 1 39  ? -18.24375 -36.23629 2.24339   1.000 36.87884  ? 39  PRO A O    1 
ATOM   571  C CB   . PRO A 1 39  ? -17.57755 -33.72171 3.95617   1.000 32.92488  ? 39  PRO A CB   1 
ATOM   572  C CG   . PRO A 1 39  ? -16.57934 -33.79940 5.07982   1.000 32.11200  ? 39  PRO A CG   1 
ATOM   573  C CD   . PRO A 1 39  ? -16.40960 -35.28008 5.34158   1.000 32.08696  ? 39  PRO A CD   1 
ATOM   574  H HA   . PRO A 1 39  ? -19.30667 -34.56998 4.71522   1.000 38.52469  ? 39  PRO A HA   1 
ATOM   575  H HB2  . PRO A 1 39  ? -17.14357 -33.83281 3.09582   1.000 40.24593  ? 39  PRO A HB2  1 
ATOM   576  H HB3  . PRO A 1 39  ? -18.06189 -32.88154 3.97740   1.000 40.24593  ? 39  PRO A HB3  1 
ATOM   577  H HG2  . PRO A 1 39  ? -15.74043 -33.39617 4.80680   1.000 39.27046  ? 39  PRO A HG2  1 
ATOM   578  H HG3  . PRO A 1 39  ? -16.92612 -33.34526 5.86366   1.000 39.27046  ? 39  PRO A HG3  1 
ATOM   579  H HD2  . PRO A 1 39  ? -15.72708 -35.65798 4.76515   1.000 39.24042  ? 39  PRO A HD2  1 
ATOM   580  H HD3  . PRO A 1 39  ? -16.18692 -35.44444 6.27126   1.000 39.24042  ? 39  PRO A HD3  1 
ATOM   581  N N    . ARG A 1 40  ? -20.27492 -35.31246 2.58263   1.000 34.38364  ? 40  ARG A N    1 
ATOM   582  C CA   . ARG A 1 40  ? -20.82753 -35.91678 1.37909   1.000 35.04076  ? 40  ARG A CA   1 
ATOM   583  C C    . ARG A 1 40  ? -20.16271 -35.38842 0.11618   1.000 37.43340  ? 40  ARG A C    1 
ATOM   584  O O    . ARG A 1 40  ? -20.18306 -36.07324 -0.91138  1.000 38.34304  ? 40  ARG A O    1 
ATOM   585  C CB   . ARG A 1 40  ? -22.33743 -35.68637 1.30556   1.000 34.93689  ? 40  ARG A CB   1 
ATOM   586  C CG   . ARG A 1 40  ? -22.78324 -34.24721 1.09039   1.000 31.57062  ? 40  ARG A CG   1 
ATOM   587  C CD   . ARG A 1 40  ? -24.29180 -34.20208 0.86771   1.000 31.10439  ? 40  ARG A CD   1 
ATOM   588  N NE   . ARG A 1 40  ? -24.82097 -32.85049 0.74221   1.000 29.91906  ? 40  ARG A NE   1 
ATOM   589  C CZ   . ARG A 1 40  ? -26.07628 -32.57073 0.41959   1.000 30.60988  ? 40  ARG A CZ   1 
ATOM   590  N NH1  . ARG A 1 40  ? -26.96737 -33.52733 0.21958   1.000 30.17223  ? 40  ARG A NH1  1 
ATOM   591  N NH2  . ARG A 1 40  ? -26.44137 -31.30198 0.27609   1.000 28.64466  ? 40  ARG A NH2  1 
ATOM   592  H H    . ARG A 1 40  ? -20.82408 -34.82202 3.02704   1.000 41.99644  ? 40  ARG A H    1 
ATOM   593  H HA   . ARG A 1 40  ? -20.67979 -36.87451 1.42190   1.000 42.78498  ? 40  ARG A HA   1 
ATOM   594  H HB2  . ARG A 1 40  ? -22.68800 -36.20834 0.56695   1.000 42.66034  ? 40  ARG A HB2  1 
ATOM   595  H HB3  . ARG A 1 40  ? -22.73073 -35.98639 2.13995   1.000 42.66034  ? 40  ARG A HB3  1 
ATOM   596  H HG2  . ARG A 1 40  ? -22.56729 -33.71657 1.87313   1.000 38.62082  ? 40  ARG A HG2  1 
ATOM   597  H HG3  . ARG A 1 40  ? -22.34127 -33.88046 0.30869   1.000 38.62082  ? 40  ARG A HG3  1 
ATOM   598  H HD2  . ARG A 1 40  ? -24.50229 -34.67997 0.05026   1.000 38.06134  ? 40  ARG A HD2  1 
ATOM   599  H HD3  . ARG A 1 40  ? -24.73257 -34.62421 1.62166   1.000 38.06134  ? 40  ARG A HD3  1 
ATOM   600  H HE   . ARG A 1 40  ? -24.28569 -32.19301 0.88639   1.000 36.63894  ? 40  ARG A HE   1 
ATOM   601  H HH11 . ARG A 1 40  ? -26.73755 -34.35233 0.29807   1.000 36.94274  ? 40  ARG A HH11 1 
ATOM   602  H HH12 . ARG A 1 40  ? -27.77664 -33.32437 0.01103   1.000 36.94274  ? 40  ARG A HH12 1 
ATOM   603  H HH21 . ARG A 1 40  ? -25.86621 -30.67325 0.39224   1.000 35.10966  ? 40  ARG A HH21 1 
ATOM   604  H HH22 . ARG A 1 40  ? -27.25296 -31.10908 0.06700   1.000 35.10966  ? 40  ARG A HH22 1 
ATOM   605  N N    . HIS A 1 41  ? -19.56366 -34.20007 0.16482   1.000 35.95222  ? 41  HIS A N    1 
ATOM   606  C CA   . HIS A 1 41  ? -18.91817 -33.65814 -1.02426  1.000 39.48099  ? 41  HIS A CA   1 
ATOM   607  C C    . HIS A 1 41  ? -17.58125 -34.32881 -1.31096  1.000 39.48152  ? 41  HIS A C    1 
ATOM   608  O O    . HIS A 1 41  ? -16.82346 -33.83496 -2.15284  1.000 43.25039  ? 41  HIS A O    1 
ATOM   609  C CB   . HIS A 1 41  ? -18.76624 -32.13288 -0.91532  1.000 38.05914  ? 41  HIS A CB   1 
ATOM   610  C CG   . HIS A 1 41  ? -17.62477 -31.66437 -0.06629  1.000 40.78034  ? 41  HIS A CG   1 
ATOM   611  N ND1  . HIS A 1 41  ? -16.30713 -31.76206 -0.46018  1.000 42.41378  ? 41  HIS A ND1  1 
ATOM   612  C CD2  . HIS A 1 41  ? -17.61102 -31.03093 1.13031   1.000 37.59199  ? 41  HIS A CD2  1 
ATOM   613  C CE1  . HIS A 1 41  ? -15.53025 -31.24004 0.47184   1.000 40.17981  ? 41  HIS A CE1  1 
ATOM   614  N NE2  . HIS A 1 41  ? -16.29688 -30.79020 1.44856   1.000 38.85125  ? 41  HIS A NE2  1 
ATOM   615  H H    . HIS A 1 41  ? -19.51966 -33.69968 0.86287   1.000 43.87873  ? 41  HIS A H    1 
ATOM   616  H HA   . HIS A 1 41  ? -19.49052 -33.81479 -1.79157  1.000 48.11325  ? 41  HIS A HA   1 
ATOM   617  H HB2  . HIS A 1 41  ? -18.63096 -31.77420 -1.80636  1.000 46.40703  ? 41  HIS A HB2  1 
ATOM   618  H HB3  . HIS A 1 41  ? -19.58032 -31.77066 -0.53195  1.000 46.40703  ? 41  HIS A HB3  1 
ATOM   619  H HD2  . HIS A 1 41  ? -18.35328 -30.80157 1.64153   1.000 45.84645  ? 41  HIS A HD2  1 
ATOM   620  H HE1  . HIS A 1 41  ? -14.60165 -31.19667 0.44484   1.000 48.95184  ? 41  HIS A HE1  1 
ATOM   621  H HE2  . HIS A 1 41  ? -16.01845 -30.40851 2.16717   1.000 47.35756  ? 41  HIS A HE2  1 
ATOM   622  N N    . VAL A 1 42  ? -17.28346 -35.45162 -0.65218  1.000 39.78831  ? 42  VAL A N    1 
ATOM   623  C CA   . VAL A 1 42  ? -16.15625 -36.26358 -1.08336  1.000 43.80749  ? 42  VAL A CA   1 
ATOM   624  C C    . VAL A 1 42  ? -16.43997 -36.89715 -2.44012  1.000 45.50660  ? 42  VAL A C    1 
ATOM   625  O O    . VAL A 1 42  ? -15.50414 -37.24696 -3.16872  1.000 47.61330  ? 42  VAL A O    1 
ATOM   626  C CB   . VAL A 1 42  ? -15.82144 -37.35562 -0.05280  1.000 41.74128  ? 42  VAL A CB   1 
ATOM   627  C CG1  . VAL A 1 42  ? -16.93200 -38.39109 0.00048   1.000 41.26348  ? 42  VAL A CG1  1 
ATOM   628  C CG2  . VAL A 1 42  ? -14.48747 -38.00783 -0.39890  1.000 45.79218  ? 42  VAL A CG2  1 
ATOM   629  H H    . VAL A 1 42  ? -17.71062 -35.75401 0.03023   1.000 48.48204  ? 42  VAL A H    1 
ATOM   630  H HA   . VAL A 1 42  ? -15.38149 -35.68429 -1.15446  1.000 53.30506  ? 42  VAL A HA   1 
ATOM   631  H HB   . VAL A 1 42  ? -15.74510 -36.95482 0.82722   1.000 50.82560  ? 42  VAL A HB   1 
ATOM   632  H HG11 . VAL A 1 42  ? -16.79199 -38.96505 0.76980   1.000 50.25225  ? 42  VAL A HG11 1 
ATOM   633  H HG12 . VAL A 1 42  ? -17.78491 -37.93569 0.07839   1.000 50.25225  ? 42  VAL A HG12 1 
ATOM   634  H HG13 . VAL A 1 42  ? -16.91162 -38.91820 -0.81355  1.000 50.25225  ? 42  VAL A HG13 1 
ATOM   635  H HG21 . VAL A 1 42  ? -14.13112 -38.43805 0.39408   1.000 55.68669  ? 42  VAL A HG21 1 
ATOM   636  H HG22 . VAL A 1 42  ? -14.62955 -38.66627 -1.09689  1.000 55.68669  ? 42  VAL A HG22 1 
ATOM   637  H HG23 . VAL A 1 42  ? -13.87285 -37.32446 -0.70897  1.000 55.68669  ? 42  VAL A HG23 1 
ATOM   638  N N    . ILE A 1 43  ? -17.72038 -37.06316 -2.79579  1.000 44.21303  ? 43  ILE A N    1 
ATOM   639  C CA   . ILE A 1 43  ? -18.08258 -37.62413 -4.09560  1.000 46.25685  ? 43  ILE A CA   1 
ATOM   640  C C    . ILE A 1 43  ? -18.05789 -36.58988 -5.20764  1.000 44.91575  ? 43  ILE A C    1 
ATOM   641  O O    . ILE A 1 43  ? -18.41043 -36.91530 -6.35041  1.000 45.54584  ? 43  ILE A O    1 
ATOM   642  C CB   . ILE A 1 43  ? -19.48252 -38.27257 -4.04952  1.000 43.28436  ? 43  ILE A CB   1 
ATOM   643  C CG1  . ILE A 1 43  ? -20.57865 -37.20405 -3.99767  1.000 41.81753  ? 43  ILE A CG1  1 
ATOM   644  C CG2  . ILE A 1 43  ? -19.60069 -39.19905 -2.84603  1.000 45.29403  ? 43  ILE A CG2  1 
ATOM   645  C CD1  . ILE A 1 43  ? -21.99656 -37.77098 -3.88820  1.000 41.64583  ? 43  ILE A CD1  1 
ATOM   646  H H    . ILE A 1 43  ? -18.39335 -36.85824 -2.30110  1.000 53.79170  ? 43  ILE A H    1 
ATOM   647  H HA   . ILE A 1 43  ? -17.43123 -38.31041 -4.30927  1.000 56.24429  ? 43  ILE A HA   1 
ATOM   648  H HB   . ILE A 1 43  ? -19.59634 -38.79112 -4.86134  1.000 52.67730  ? 43  ILE A HB   1 
ATOM   649  H HG12 . ILE A 1 43  ? -20.42614 -36.63950 -3.22377  1.000 50.91710  ? 43  ILE A HG12 1 
ATOM   650  H HG13 . ILE A 1 43  ? -20.53472 -36.67398 -4.80883  1.000 50.91710  ? 43  ILE A HG13 1 
ATOM   651  H HG21 . ILE A 1 43  ? -20.19979 -39.92917 -3.06717  1.000 55.08890  ? 43  ILE A HG21 1 
ATOM   652  H HG22 . ILE A 1 43  ? -18.72189 -39.54681 -2.62771  1.000 55.08890  ? 43  ILE A HG22 1 
ATOM   653  H HG23 . ILE A 1 43  ? -19.95389 -38.69733 -2.09474  1.000 55.08890  ? 43  ILE A HG23 1 
ATOM   654  H HD11 . ILE A 1 43  ? -22.61640 -37.15475 -4.30885  1.000 50.71107  ? 43  ILE A HD11 1 
ATOM   655  H HD12 . ILE A 1 43  ? -22.02861 -38.63028 -4.33706  1.000 50.71107  ? 43  ILE A HD12 1 
ATOM   656  H HD13 . ILE A 1 43  ? -22.22209 -37.87875 -2.95096  1.000 50.71107  ? 43  ILE A HD13 1 
ATOM   657  N N    . CYS A 1 44  ? -17.66317 -35.35629 -4.90797  1.000 45.22145  ? 44  CYS A N    1 
ATOM   658  C CA   . CYS A 1 44  ? -17.64689 -34.27959 -5.88384  1.000 49.55702  ? 44  CYS A CA   1 
ATOM   659  C C    . CYS A 1 44  ? -16.22960 -33.99421 -6.36331  1.000 56.86526  ? 44  CYS A C    1 
ATOM   660  O O    . CYS A 1 44  ? -15.25365 -34.18619 -5.63555  1.000 57.48326  ? 44  CYS A O    1 
ATOM   661  C CB   . CYS A 1 44  ? -18.22949 -32.99207 -5.29341  1.000 48.87167  ? 44  CYS A CB   1 
ATOM   662  S SG   . CYS A 1 44  ? -19.97679 -33.03506 -4.87210  1.000 41.40181  ? 44  CYS A SG   1 
ATOM   663  H H    . CYS A 1 44  ? -17.39463 -35.11596 -4.12712  1.000 55.00181  ? 44  CYS A H    1 
ATOM   664  H HA   . CYS A 1 44  ? -18.18289 -34.55244 -6.64486  1.000 60.20450  ? 44  CYS A HA   1 
ATOM   665  H HB2  . CYS A 1 44  ? -17.74386 -32.78562 -4.47951  1.000 59.38207  ? 44  CYS A HB2  1 
ATOM   666  H HB3  . CYS A 1 44  ? -18.10877 -32.28038 -5.94135  1.000 59.38207  ? 44  CYS A HB3  1 
ATOM   667  H HG   . CYS A 1 44  ? -20.31346 -31.94837 -4.49032  1.000 50.41824  ? 44  CYS A HG   1 
ATOM   668  N N    . THR A 1 45  ? -16.13112 -33.52230 -7.60082  1.000 57.26589  ? 45  THR A N    1 
ATOM   669  C CA   . THR A 1 45  ? -14.93559 -32.85386 -8.08340  1.000 61.94475  ? 45  THR A CA   1 
ATOM   670  C C    . THR A 1 45  ? -15.07636 -31.35075 -7.84275  1.000 63.29750  ? 45  THR A C    1 
ATOM   671  O O    . THR A 1 45  ? -16.15197 -30.84826 -7.50650  1.000 62.32825  ? 45  THR A O    1 
ATOM   672  C CB   . THR A 1 45  ? -14.71162 -33.14304 -9.56566  1.000 60.66846  ? 45  THR A CB   1 
ATOM   673  O OG1  . THR A 1 45  ? -15.77030 -32.56663 -10.33927 1.000 60.53269  ? 45  THR A OG1  1 
ATOM   674  C CG2  . THR A 1 45  ? -14.67023 -34.64389 -9.81606  1.000 61.36453  ? 45  THR A CG2  1 
ATOM   675  H H    . THR A 1 45  ? -16.75611 -33.57929 -8.18882  1.000 69.45513  ? 45  THR A H    1 
ATOM   676  H HA   . THR A 1 45  ? -14.15761 -33.18359 -7.60703  1.000 75.06976  ? 45  THR A HA   1 
ATOM   677  H HB   . THR A 1 45  ? -13.86467 -32.75929 -9.84191  1.000 73.53822  ? 45  THR A HB   1 
ATOM   678  H HG1  . THR A 1 45  ? -15.64574 -32.71976 -11.15575 1.000 73.37530  ? 45  THR A HG1  1 
ATOM   679  H HG21 . THR A 1 45  ? -14.22838 -34.82740 -10.65986 1.000 74.37350  ? 45  THR A HG21 1 
ATOM   680  H HG22 . THR A 1 45  ? -14.18325 -35.08589 -9.10305  1.000 74.37350  ? 45  THR A HG22 1 
ATOM   681  H HG23 . THR A 1 45  ? -15.57200 -34.99973 -9.84900  1.000 74.37350  ? 45  THR A HG23 1 
ATOM   682  N N    . SER A 1 46  ? -13.96862 -30.62503 -8.01148  1.000 66.84253  ? 46  SER A N    1 
ATOM   683  C CA   . SER A 1 46  ? -14.03303 -29.17108 -7.89709  1.000 67.48126  ? 46  SER A CA   1 
ATOM   684  C C    . SER A 1 46  ? -15.00969 -28.58242 -8.90825  1.000 65.95959  ? 46  SER A C    1 
ATOM   685  O O    . SER A 1 46  ? -15.58896 -27.51661 -8.66681  1.000 63.93305  ? 46  SER A O    1 
ATOM   686  C CB   . SER A 1 46  ? -12.64350 -28.56333 -8.08457  1.000 88.60956  ? 46  SER A CB   1 
ATOM   687  H H    . SER A 1 46  ? -13.18918 -30.94265 -8.18809  1.000 80.94710  ? 46  SER A H    1 
ATOM   688  H HA   . SER A 1 46  ? -14.33907 -28.93901 -7.00637  1.000 81.71358  ? 46  SER A HA   1 
ATOM   689  N N    . GLU A 1 47  ? -15.20722 -29.26274 -10.04182 1.000 65.77540  ? 47  GLU A N    1 
ATOM   690  C CA   . GLU A 1 47  ? -16.17433 -28.79710 -11.02994 1.000 64.43270  ? 47  GLU A CA   1 
ATOM   691  C C    . GLU A 1 47  ? -17.60219 -29.05942 -10.56859 1.000 59.97385  ? 47  GLU A C    1 
ATOM   692  O O    . GLU A 1 47  ? -18.49652 -28.23567 -10.79614 1.000 59.70953  ? 47  GLU A O    1 
ATOM   693  C CB   . GLU A 1 47  ? -15.91606 -29.47768 -12.37471 1.000 71.21956  ? 47  GLU A CB   1 
ATOM   694  H H    . GLU A 1 47  ? -14.79789 -29.98759 -10.25778 1.000 79.66655  ? 47  GLU A H    1 
ATOM   695  H HA   . GLU A 1 47  ? -16.06496 -27.84057 -11.14821 1.000 78.05530  ? 47  GLU A HA   1 
ATOM   696  N N    . ASP A 1 48  ? -17.83546 -30.20373 -9.92095  1.000 59.23730  ? 48  ASP A N    1 
ATOM   697  C CA   . ASP A 1 48  ? -19.17237 -30.51178 -9.42873  1.000 56.14817  ? 48  ASP A CA   1 
ATOM   698  C C    . ASP A 1 48  ? -19.59432 -29.56943 -8.30952  1.000 52.72761  ? 48  ASP A C    1 
ATOM   699  O O    . ASP A 1 48  ? -20.79461 -29.36495 -8.09190  1.000 49.84795  ? 48  ASP A O    1 
ATOM   700  C CB   . ASP A 1 48  ? -19.23268 -31.95358 -8.92208  1.000 55.11541  ? 48  ASP A CB   1 
ATOM   701  C CG   . ASP A 1 48  ? -18.95335 -32.96732 -10.00713 1.000 55.77395  ? 48  ASP A CG   1 
ATOM   702  O OD1  . ASP A 1 48  ? -19.43146 -32.76871 -11.14231 1.000 55.54506  ? 48  ASP A OD1  1 
ATOM   703  O OD2  . ASP A 1 48  ? -18.25477 -33.96227 -9.72132  1.000 57.56005  ? 48  ASP A OD2  1 
ATOM   704  H H    . ASP A 1 48  ? -17.24480 -30.80707 -9.75753  1.000 71.82083  ? 48  ASP A H    1 
ATOM   705  H HA   . ASP A 1 48  ? -19.79410 -30.41573 -10.16706 1.000 68.11388  ? 48  ASP A HA   1 
ATOM   706  H HB2  . ASP A 1 48  ? -18.56955 -32.07119 -8.22399  1.000 66.87457  ? 48  ASP A HB2  1 
ATOM   707  H HB3  . ASP A 1 48  ? -20.11955 -32.12794 -8.56999  1.000 66.87457  ? 48  ASP A HB3  1 
ATOM   708  N N    . MET A 1 49  ? -18.62951 -28.99030 -7.59105  1.000 55.71188  ? 49  MET A N    1 
ATOM   709  C CA   . MET A 1 49  ? -18.94695 -28.23402 -6.38752  1.000 53.25731  ? 49  MET A CA   1 
ATOM   710  C C    . MET A 1 49  ? -19.70791 -26.94981 -6.68315  1.000 50.07745  ? 49  MET A C    1 
ATOM   711  O O    . MET A 1 49  ? -20.28941 -26.36616 -5.76270  1.000 47.29615  ? 49  MET A O    1 
ATOM   712  C CB   . MET A 1 49  ? -17.66389 -27.90426 -5.62317  1.000 55.84959  ? 49  MET A CB   1 
ATOM   713  C CG   . MET A 1 49  ? -17.83439 -27.88381 -4.11500  1.000 58.55494  ? 49  MET A CG   1 
ATOM   714  S SD   . MET A 1 49  ? -18.16911 -29.52480 -3.45245  1.000 71.30956  ? 49  MET A SD   1 
ATOM   715  C CE   . MET A 1 49  ? -16.62405 -30.35202 -3.81786  1.000 58.83606  ? 49  MET A CE   1 
ATOM   716  H H    . MET A 1 49  ? -17.79120 -29.02206 -7.78034  1.000 67.59032  ? 49  MET A H    1 
ATOM   717  H HA   . MET A 1 49  ? -19.50062 -28.79320 -5.82036  1.000 64.64484  ? 49  MET A HA   1 
ATOM   718  H HB2  . MET A 1 49  ? -16.99432 -28.57310 -5.83583  1.000 67.75557  ? 49  MET A HB2  1 
ATOM   719  H HB3  . MET A 1 49  ? -17.35500 -27.02665 -5.89757  1.000 67.75557  ? 49  MET A HB3  1 
ATOM   720  H HG2  . MET A 1 49  ? -17.01968 -27.55207 -3.70624  1.000 71.00200  ? 49  MET A HG2  1 
ATOM   721  H HG3  . MET A 1 49  ? -18.57943 -27.30646 -3.88590  1.000 71.00200  ? 49  MET A HG3  1 
ATOM   722  H HE1  . MET A 1 49  ? -15.88832 -29.76634 -3.58001  1.000 71.33934  ? 49  MET A HE1  1 
ATOM   723  H HE2  . MET A 1 49  ? -16.57475 -31.17156 -3.30131  1.000 71.33934  ? 49  MET A HE2  1 
ATOM   724  H HE3  . MET A 1 49  ? -16.59145 -30.55592 -4.76562  1.000 71.33934  ? 49  MET A HE3  1 
ATOM   725  N N    . PHE A 1 50  ? -19.71768 -26.49542 -7.93619  1.000 50.05176  ? 50  PHE A N    1 
ATOM   726  C CA   . PHE A 1 50  ? -20.45588 -25.28113 -8.27083  1.000 50.50070  ? 50  PHE A CA   1 
ATOM   727  C C    . PHE A 1 50  ? -21.93726 -25.43268 -7.93324  1.000 49.74071  ? 50  PHE A C    1 
ATOM   728  O O    . PHE A 1 50  ? -22.51927 -24.58738 -7.24331  1.000 49.63174  ? 50  PHE A O    1 
ATOM   729  C CB   . PHE A 1 50  ? -20.26834 -24.94545 -9.75147  1.000 50.72742  ? 50  PHE A CB   1 
ATOM   730  H H    . PHE A 1 50  ? -19.31240 -26.86506 -8.59855  1.000 60.79818  ? 50  PHE A H    1 
ATOM   731  H HA   . PHE A 1 50  ? -20.10165 -24.54372 -7.74964  1.000 61.33690  ? 50  PHE A HA   1 
ATOM   732  N N    . ASN A 1 51  ? -22.56620 -26.50427 -8.41883  1.000 49.58151  ? 51  ASN A N    1 
ATOM   733  C CA   . ASN A 1 51  ? -23.96301 -26.77120 -8.12199  1.000 50.38846  ? 51  ASN A CA   1 
ATOM   734  C C    . ASN A 1 51  ? -24.20691 -28.27809 -8.23016  1.000 47.68894  ? 51  ASN A C    1 
ATOM   735  O O    . ASN A 1 51  ? -24.77967 -28.74030 -9.22949  1.000 48.77982  ? 51  ASN A O    1 
ATOM   736  C CB   . ASN A 1 51  ? -24.89521 -26.01319 -9.06231  1.000 54.01892  ? 51  ASN A CB   1 
ATOM   737  C CG   . ASN A 1 51  ? -26.35296 -26.11005 -8.63552  1.000 62.56562  ? 51  ASN A CG   1 
ATOM   738  O OD1  . ASN A 1 51  ? -26.70082 -25.86280 -7.48082  1.000 61.45048  ? 51  ASN A OD1  1 
ATOM   739  N ND2  . ASN A 1 51  ? -27.21107 -26.48944 -9.57423  1.000 59.68271  ? 51  ASN A ND2  1 
ATOM   740  H H    . ASN A 1 51  ? -22.19813 -27.09315 -8.92613  1.000 60.23388  ? 51  ASN A H    1 
ATOM   741  H HA   . ASN A 1 51  ? -24.16398 -26.47240 -7.22130  1.000 61.20222  ? 51  ASN A HA   1 
ATOM   742  H HB2  . ASN A 1 51  ? -24.64496 -25.07606 -9.07019  1.000 65.55878  ? 51  ASN A HB2  1 
ATOM   743  H HB3  . ASN A 1 51  ? -24.81698 -26.38498 -9.95481  1.000 65.55878  ? 51  ASN A HB3  1 
ATOM   744  H HD21 . ASN A 1 51  ? -26.93047 -26.66365 -10.36828 1.000 72.35532  ? 51  ASN A HD21 1 
ATOM   745  H HD22 . ASN A 1 51  ? -28.04770 -26.56106 -9.38845  1.000 72.35532  ? 51  ASN A HD22 1 
ATOM   746  N N    . PRO A 1 52  ? -23.77252 -29.05868 -7.25102  1.000 47.18996  ? 52  PRO A N    1 
ATOM   747  C CA   . PRO A 1 52  ? -23.92366 -30.51267 -7.35180  1.000 43.30604  ? 52  PRO A CA   1 
ATOM   748  C C    . PRO A 1 52  ? -25.33489 -30.95073 -7.00210  1.000 39.20222  ? 52  PRO A C    1 
ATOM   749  O O    . PRO A 1 52  ? -25.95142 -30.44874 -6.06145  1.000 40.28728  ? 52  PRO A O    1 
ATOM   750  C CB   . PRO A 1 52  ? -22.90515 -31.03827 -6.33532  1.000 42.65447  ? 52  PRO A CB   1 
ATOM   751  C CG   . PRO A 1 52  ? -22.87810 -29.96968 -5.27876  1.000 42.39312  ? 52  PRO A CG   1 
ATOM   752  C CD   . PRO A 1 52  ? -23.09335 -28.64823 -6.00405  1.000 47.52525  ? 52  PRO A CD   1 
ATOM   753  H HA   . PRO A 1 52  ? -23.69542 -30.83027 -8.23946  1.000 52.70332  ? 52  PRO A HA   1 
ATOM   754  H HB2  . PRO A 1 52  ? -23.20161 -31.88684 -5.97073  1.000 51.92143  ? 52  PRO A HB2  1 
ATOM   755  H HB3  . PRO A 1 52  ? -22.03616 -31.14233 -6.75355  1.000 51.92143  ? 52  PRO A HB3  1 
ATOM   756  H HG2  . PRO A 1 52  ? -23.58861 -30.12772 -4.63759  1.000 51.60781  ? 52  PRO A HG2  1 
ATOM   757  H HG3  . PRO A 1 52  ? -22.01830 -29.97743 -4.82979  1.000 51.60781  ? 52  PRO A HG3  1 
ATOM   758  H HD2  . PRO A 1 52  ? -23.65617 -28.05480 -5.48253  1.000 57.76637  ? 52  PRO A HD2  1 
ATOM   759  H HD3  . PRO A 1 52  ? -22.24605 -28.21729 -6.19707  1.000 57.76637  ? 52  PRO A HD3  1 
ATOM   760  N N    . ASN A 1 53  ? -25.85330 -31.87611 -7.79738  1.000 38.96420  ? 53  ASN A N    1 
ATOM   761  C CA   . ASN A 1 53  ? -27.03754 -32.65087 -7.43954  1.000 40.00942  ? 53  ASN A CA   1 
ATOM   762  C C    . ASN A 1 53  ? -26.52315 -33.88654 -6.70731  1.000 38.40023  ? 53  ASN A C    1 
ATOM   763  O O    . ASN A 1 53  ? -26.12872 -34.86983 -7.34660  1.000 36.26305  ? 53  ASN A O    1 
ATOM   764  C CB   . ASN A 1 53  ? -27.85700 -32.99977 -8.67634  1.000 37.63681  ? 53  ASN A CB   1 
ATOM   765  C CG   . ASN A 1 53  ? -29.21222 -33.58245 -8.32627  1.000 39.24280  ? 53  ASN A CG   1 
ATOM   766  O OD1  . ASN A 1 53  ? -29.30479 -34.54620 -7.56228  1.000 42.45791  ? 53  ASN A OD1  1 
ATOM   767  N ND2  . ASN A 1 53  ? -30.27204 -32.99958 -8.87329  1.000 39.67351  ? 53  ASN A ND2  1 
ATOM   768  H H    . ASN A 1 53  ? -25.53099 -32.07996 -8.56819  1.000 47.49311  ? 53  ASN A H    1 
ATOM   769  H HA   . ASN A 1 53  ? -27.62128 -32.14649 -6.85153  1.000 48.74738  ? 53  ASN A HA   1 
ATOM   770  H HB2  . ASN A 1 53  ? -28.00067 -32.19549 -9.19921  1.000 45.90024  ? 53  ASN A HB2  1 
ATOM   771  H HB3  . ASN A 1 53  ? -27.37371 -33.65574 -9.20268  1.000 45.90024  ? 53  ASN A HB3  1 
ATOM   772  H HD21 . ASN A 1 53  ? -31.06130 -33.29592 -8.70341  1.000 48.34428  ? 53  ASN A HD21 1 
ATOM   773  H HD22 . ASN A 1 53  ? -30.16939 -32.32563 -9.39756  1.000 48.34428  ? 53  ASN A HD22 1 
ATOM   774  N N    . TYR A 1 54  ? -26.48486 -33.82431 -5.37645  1.000 37.64079  ? 54  TYR A N    1 
ATOM   775  C CA   . TYR A 1 54  ? -25.80357 -34.87111 -4.62453  1.000 36.49007  ? 54  TYR A CA   1 
ATOM   776  C C    . TYR A 1 54  ? -26.47953 -36.22127 -4.80930  1.000 36.98771  ? 54  TYR A C    1 
ATOM   777  O O    . TYR A 1 54  ? -25.80461 -37.25425 -4.88106  1.000 35.65914  ? 54  TYR A O    1 
ATOM   778  C CB   . TYR A 1 54  ? -25.74658 -34.50618 -3.14671  1.000 35.54931  ? 54  TYR A CB   1 
ATOM   779  C CG   . TYR A 1 54  ? -24.62450 -33.56301 -2.80946  1.000 32.38279  ? 54  TYR A CG   1 
ATOM   780  C CD1  . TYR A 1 54  ? -23.31770 -34.01609 -2.70349  1.000 32.81398  ? 54  TYR A CD1  1 
ATOM   781  C CD2  . TYR A 1 54  ? -24.86736 -32.21104 -2.60462  1.000 33.30590  ? 54  TYR A CD2  1 
ATOM   782  C CE1  . TYR A 1 54  ? -22.28675 -33.15720 -2.40228  1.000 33.18220  ? 54  TYR A CE1  1 
ATOM   783  C CE2  . TYR A 1 54  ? -23.83850 -31.34323 -2.29470  1.000 33.12493  ? 54  TYR A CE2  1 
ATOM   784  C CZ   . TYR A 1 54  ? -22.54780 -31.82238 -2.19824  1.000 32.81717  ? 54  TYR A CZ   1 
ATOM   785  O OH   . TYR A 1 54  ? -21.50954 -30.97247 -1.89717  1.000 34.23512  ? 54  TYR A OH   1 
ATOM   786  H H    . TYR A 1 54  ? -26.83678 -33.20215 -4.89826  1.000 45.90502  ? 54  TYR A H    1 
ATOM   787  H HA   . TYR A 1 54  ? -24.89423 -34.94234 -4.95456  1.000 44.52415  ? 54  TYR A HA   1 
ATOM   788  H HB2  . TYR A 1 54  ? -26.58060 -34.07850 -2.89692  1.000 43.39524  ? 54  TYR A HB2  1 
ATOM   789  H HB3  . TYR A 1 54  ? -25.62089 -35.31632 -2.62827  1.000 43.39524  ? 54  TYR A HB3  1 
ATOM   790  H HD1  . TYR A 1 54  ? -23.13527 -34.91794 -2.83873  1.000 40.11284  ? 54  TYR A HD1  1 
ATOM   791  H HD2  . TYR A 1 54  ? -25.73541 -31.88527 -2.67720  1.000 40.70315  ? 54  TYR A HD2  1 
ATOM   792  H HE1  . TYR A 1 54  ? -21.41622 -33.47782 -2.33679  1.000 40.55471  ? 54  TYR A HE1  1 
ATOM   793  H HE2  . TYR A 1 54  ? -24.01444 -30.44127 -2.15184  1.000 40.48598  ? 54  TYR A HE2  1 
ATOM   794  H HH   . TYR A 1 54  ? -21.78522 -30.17936 -1.87318  1.000 41.81822  ? 54  TYR A HH   1 
ATOM   795  N N    . GLU A 1 55  ? -27.81231 -36.24090 -4.86185  1.000 38.07580  ? 55  GLU A N    1 
ATOM   796  C CA   . GLU A 1 55  ? -28.51522 -37.50455 -5.05726  1.000 39.71921  ? 55  GLU A CA   1 
ATOM   797  C C    . GLU A 1 55  ? -28.07557 -38.16684 -6.35823  1.000 39.20172  ? 55  GLU A C    1 
ATOM   798  O O    . GLU A 1 55  ? -27.76188 -39.36284 -6.38895  1.000 39.75570  ? 55  GLU A O    1 
ATOM   799  C CB   . GLU A 1 55  ? -30.02769 -37.27760 -5.04548  1.000 40.96570  ? 55  GLU A CB   1 
ATOM   800  C CG   . GLU A 1 55  ? -30.61120 -36.97576 -3.66932  1.000 47.21666  ? 55  GLU A CG   1 
ATOM   801  C CD   . GLU A 1 55  ? -30.27529 -35.57852 -3.17698  1.000 66.22672  ? 55  GLU A CD   1 
ATOM   802  O OE1  . GLU A 1 55  ? -29.86187 -34.73779 -4.00290  1.000 49.54655  ? 55  GLU A OE1  1 
ATOM   803  O OE2  . GLU A 1 55  ? -30.42605 -35.32412 -1.96318  1.000 69.08387  ? 55  GLU A OE2  1 
ATOM   804  H H    . GLU A 1 55  ? -28.32057 -35.55105 -4.78858  1.000 46.42703  ? 55  GLU A H    1 
ATOM   805  H HA   . GLU A 1 55  ? -28.30267 -38.10146 -4.32281  1.000 48.39912  ? 55  GLU A HA   1 
ATOM   806  H HB2  . GLU A 1 55  ? -30.23154 -36.52443 -5.62174  1.000 49.89491  ? 55  GLU A HB2  1 
ATOM   807  H HB3  . GLU A 1 55  ? -30.46273 -38.07783 -5.37905  1.000 49.89491  ? 55  GLU A HB3  1 
ATOM   808  H HG2  . GLU A 1 55  ? -31.57712 -37.05355 -3.71238  1.000 57.39606  ? 55  GLU A HG2  1 
ATOM   809  H HG3  . GLU A 1 55  ? -30.25532 -37.61198 -3.02943  1.000 57.39606  ? 55  GLU A HG3  1 
ATOM   810  N N    . ASP A 1 56  ? -28.01802 -37.38911 -7.44149  1.000 38.05870  ? 56  ASP A N    1 
ATOM   811  C CA   . ASP A 1 56  ? -27.61669 -37.94229 -8.73035  1.000 39.69631  ? 56  ASP A CA   1 
ATOM   812  C C    . ASP A 1 56  ? -26.15528 -38.38449 -8.71618  1.000 40.24935  ? 56  ASP A C    1 
ATOM   813  O O    . ASP A 1 56  ? -25.79422 -39.38596 -9.34471  1.000 40.73294  ? 56  ASP A O    1 
ATOM   814  C CB   . ASP A 1 56  ? -27.85417 -36.91709 -9.83779  1.000 39.47759  ? 56  ASP A CB   1 
ATOM   815  C CG   . ASP A 1 56  ? -29.32196 -36.75722 -10.18530 1.000 39.63779  ? 56  ASP A CG   1 
ATOM   816  O OD1  . ASP A 1 56  ? -30.17897 -37.39989 -9.54082  1.000 39.11542  ? 56  ASP A OD1  1 
ATOM   817  O OD2  . ASP A 1 56  ? -29.61859 -35.98298 -11.11835 1.000 42.40587  ? 56  ASP A OD2  1 
ATOM   818  H H    . ASP A 1 56  ? -28.20410 -36.54960 -7.45511  1.000 46.40651  ? 56  ASP A H    1 
ATOM   819  H HA   . ASP A 1 56  ? -28.16382 -38.72114 -8.91727  1.000 48.37164  ? 56  ASP A HA   1 
ATOM   820  H HB2  . ASP A 1 56  ? -27.51923 -36.05446 -9.54697  1.000 48.10917  ? 56  ASP A HB2  1 
ATOM   821  H HB3  . ASP A 1 56  ? -27.38592 -37.20217 -10.63803 1.000 48.10917  ? 56  ASP A HB3  1 
ATOM   822  N N    . LEU A 1 57  ? -25.28865 -37.64018 -8.02346  1.000 38.95153  ? 57  LEU A N    1 
ATOM   823  C CA   . LEU A 1 57  ? -23.88087 -38.02709 -7.96787  1.000 39.62338  ? 57  LEU A CA   1 
ATOM   824  C C    . LEU A 1 57  ? -23.68435 -39.29790 -7.15123  1.000 42.93351  ? 57  LEU A C    1 
ATOM   825  O O    . LEU A 1 57  ? -22.90393 -40.17767 -7.53845  1.000 44.59451  ? 57  LEU A O    1 
ATOM   826  C CB   . LEU A 1 57  ? -23.04535 -36.89255 -7.38433  1.000 39.80977  ? 57  LEU A CB   1 
ATOM   827  C CG   . LEU A 1 57  ? -22.88891 -35.68714 -8.31074  1.000 41.06503  ? 57  LEU A CG   1 
ATOM   828  C CD1  . LEU A 1 57  ? -22.31536 -34.50871 -7.54953  1.000 42.05128  ? 57  LEU A CD1  1 
ATOM   829  C CD2  . LEU A 1 57  ? -22.01420 -36.05312 -9.50123  1.000 43.17220  ? 57  LEU A CD2  1 
ATOM   830  H H    . LEU A 1 57  ? -25.48638 -36.92514 -7.58845  1.000 47.47790  ? 57  LEU A H    1 
ATOM   831  H HA   . LEU A 1 57  ? -23.57403 -38.19696 -8.87224  1.000 48.28413  ? 57  LEU A HA   1 
ATOM   832  H HB2  . LEU A 1 57  ? -23.46972 -36.58402 -6.56847  1.000 48.50779  ? 57  LEU A HB2  1 
ATOM   833  H HB3  . LEU A 1 57  ? -22.15762 -37.23117 -7.18896  1.000 48.50779  ? 57  LEU A HB3  1 
ATOM   834  H HG   . LEU A 1 57  ? -23.75777 -35.42161 -8.65058  1.000 50.01411  ? 57  LEU A HG   1 
ATOM   835  H HD11 . LEU A 1 57  ? -22.27477 -33.74058 -8.14048  1.000 51.19760  ? 57  LEU A HD11 1 
ATOM   836  H HD12 . LEU A 1 57  ? -22.88843 -34.31312 -6.79174  1.000 51.19760  ? 57  LEU A HD12 1 
ATOM   837  H HD13 . LEU A 1 57  ? -21.42437 -34.73578 -7.24054  1.000 51.19760  ? 57  LEU A HD13 1 
ATOM   838  H HD21 . LEU A 1 57  ? -21.73737 -35.23983 -9.95158  1.000 52.54271  ? 57  LEU A HD21 1 
ATOM   839  H HD22 . LEU A 1 57  ? -21.23563 -36.53706 -9.18414  1.000 52.54271  ? 57  LEU A HD22 1 
ATOM   840  H HD23 . LEU A 1 57  ? -22.52508 -36.61031 -10.10905 1.000 52.54271  ? 57  LEU A HD23 1 
ATOM   841  N N    . LEU A 1 58  ? -24.37236 -39.40785 -6.01105  1.000 39.37447  ? 58  LEU A N    1 
ATOM   842  C CA   . LEU A 1 58  ? -24.22220 -40.59785 -5.18166  1.000 45.19114  ? 58  LEU A CA   1 
ATOM   843  C C    . LEU A 1 58  ? -24.78768 -41.83161 -5.87189  1.000 43.20985  ? 58  LEU A C    1 
ATOM   844  O O    . LEU A 1 58  ? -24.27182 -42.93957 -5.68266  1.000 46.27221  ? 58  LEU A O    1 
ATOM   845  C CB   . LEU A 1 58  ? -24.90600 -40.39419 -3.83037  1.000 41.42156  ? 58  LEU A CB   1 
ATOM   846  C CG   . LEU A 1 58  ? -24.76321 -41.54012 -2.82592  1.000 43.88263  ? 58  LEU A CG   1 
ATOM   847  C CD1  . LEU A 1 58  ? -23.29205 -41.81368 -2.53957  1.000 51.22182  ? 58  LEU A CD1  1 
ATOM   848  C CD2  . LEU A 1 58  ? -25.51080 -41.23556 -1.53507  1.000 45.27372  ? 58  LEU A CD2  1 
ATOM   849  H H    . LEU A 1 58  ? -24.91956 -38.81946 -5.70451  1.000 47.98543  ? 58  LEU A H    1 
ATOM   850  H HA   . LEU A 1 58  ? -23.27718 -40.74385 -5.01881  1.000 54.96544  ? 58  LEU A HA   1 
ATOM   851  H HB2  . LEU A 1 58  ? -24.52902 -39.60166 -3.41722  1.000 50.44194  ? 58  LEU A HB2  1 
ATOM   852  H HB3  . LEU A 1 58  ? -25.85465 -40.26694 -3.98777  1.000 50.44194  ? 58  LEU A HB3  1 
ATOM   853  H HG   . LEU A 1 58  ? -25.15491 -42.34014 -3.20990  1.000 53.39523  ? 58  LEU A HG   1 
ATOM   854  H HD11 . LEU A 1 58  ? -23.22140 -42.34921 -1.73389  1.000 62.20225  ? 58  LEU A HD11 1 
ATOM   855  H HD12 . LEU A 1 58  ? -22.90806 -42.29322 -3.29023  1.000 62.20225  ? 58  LEU A HD12 1 
ATOM   856  H HD13 . LEU A 1 58  ? -22.83184 -40.96871 -2.41652  1.000 62.20225  ? 58  LEU A HD13 1 
ATOM   857  H HD21 . LEU A 1 58  ? -25.85081 -42.06472 -1.16388  1.000 55.06453  ? 58  LEU A HD21 1 
ATOM   858  H HD22 . LEU A 1 58  ? -24.90027 -40.81803 -0.90752  1.000 55.06453  ? 58  LEU A HD22 1 
ATOM   859  H HD23 . LEU A 1 58  ? -26.24654 -40.63441 -1.73053  1.000 55.06453  ? 58  LEU A HD23 1 
ATOM   860  N N    . ILE A 1 59  ? -25.84506 -41.66295 -6.66953  1.000 43.01657  ? 59  ILE A N    1 
ATOM   861  C CA   . ILE A 1 59  ? -26.45475 -42.80089 -7.34448  1.000 45.19258  ? 59  ILE A CA   1 
ATOM   862  C C    . ILE A 1 59  ? -25.51611 -43.40015 -8.37987  1.000 44.59346  ? 59  ILE A C    1 
ATOM   863  O O    . ILE A 1 59  ? -25.67907 -44.56889 -8.74849  1.000 48.56245  ? 59  ILE A O    1 
ATOM   864  C CB   . ILE A 1 59  ? -27.81282 -42.37780 -7.94738  1.000 42.44284  ? 59  ILE A CB   1 
ATOM   865  C CG1  . ILE A 1 59  ? -28.86039 -42.30025 -6.82374  1.000 45.16144  ? 59  ILE A CG1  1 
ATOM   866  C CG2  . ILE A 1 59  ? -28.23224 -43.33221 -9.04751  1.000 45.23314  ? 59  ILE A CG2  1 
ATOM   867  C CD1  . ILE A 1 59  ? -30.24630 -41.85043 -7.26084  1.000 51.93137  ? 59  ILE A CD1  1 
ATOM   868  H H    . ILE A 1 59  ? -26.22177 -40.90724 -6.83261  1.000 52.35595  ? 59  ILE A H    1 
ATOM   869  H HA   . ILE A 1 59  ? -26.63365 -43.50413 -6.70078  1.000 54.96716  ? 59  ILE A HA   1 
ATOM   870  H HB   . ILE A 1 59  ? -27.72928 -41.50006 -8.35172  1.000 51.66747  ? 59  ILE A HB   1 
ATOM   871  H HG12 . ILE A 1 59  ? -28.95257 -43.18169 -6.42946  1.000 54.92979  ? 59  ILE A HG12 1 
ATOM   872  H HG13 . ILE A 1 59  ? -28.54782 -41.66939 -6.15649  1.000 54.92979  ? 59  ILE A HG13 1 
ATOM   873  H HG21 . ILE A 1 59  ? -29.15790 -43.15895 -9.27999  1.000 55.01583  ? 59  ILE A HG21 1 
ATOM   874  H HG22 . ILE A 1 59  ? -27.66481 -43.19099 -9.82144  1.000 55.01583  ? 59  ILE A HG22 1 
ATOM   875  H HG23 . ILE A 1 59  ? -28.13621 -44.24330 -8.72878  1.000 55.01583  ? 59  ILE A HG23 1 
ATOM   876  H HD11 . ILE A 1 59  ? -30.79475 -41.70731 -6.47369  1.000 63.05371  ? 59  ILE A HD11 1 
ATOM   877  H HD12 . ILE A 1 59  ? -30.16645 -41.02438 -7.76301  1.000 63.05371  ? 59  ILE A HD12 1 
ATOM   878  H HD13 . ILE A 1 59  ? -30.64082 -42.53945 -7.81806  1.000 63.05371  ? 59  ILE A HD13 1 
ATOM   879  N N    . ARG A 1 60  ? -24.52139 -42.64985 -8.84096  1.000 42.69028  ? 60  ARG A N    1 
ATOM   880  C CA   . ARG A 1 60  ? -23.51529 -43.20030 -9.74018  1.000 48.11131  ? 60  ARG A CA   1 
ATOM   881  C C    . ARG A 1 60  ? -22.41205 -43.95218 -9.00356  1.000 53.47347  ? 60  ARG A C    1 
ATOM   882  O O    . ARG A 1 60  ? -21.53778 -44.53222 -9.65861  1.000 51.43607  ? 60  ARG A O    1 
ATOM   883  C CB   . ARG A 1 60  ? -22.90100 -42.08764 -10.58850 1.000 50.78203  ? 60  ARG A CB   1 
ATOM   884  H H    . ARG A 1 60  ? -24.40770 -41.81963 -8.64755  1.000 51.96441  ? 60  ARG A H    1 
ATOM   885  H HA   . ARG A 1 60  ? -23.94940 -43.82465 -10.34237 1.000 58.46963  ? 60  ARG A HA   1 
ATOM   886  N N    . LYS A 1 61  ? -22.43478 -43.96188 -7.67324  1.000 51.93506  ? 61  LYS A N    1 
ATOM   887  C CA   . LYS A 1 61  ? -21.40106 -44.59558 -6.87110  1.000 55.56008  ? 61  LYS A CA   1 
ATOM   888  C C    . LYS A 1 61  ? -21.89781 -45.91871 -6.29811  1.000 59.25466  ? 61  LYS A C    1 
ATOM   889  O O    . LYS A 1 61  ? -23.08015 -46.07797 -5.98309  1.000 56.96110  ? 61  LYS A O    1 
ATOM   890  C CB   . LYS A 1 61  ? -20.96410 -43.67959 -5.72280  1.000 55.57786  ? 61  LYS A CB   1 
ATOM   891  C CG   . LYS A 1 61  ? -20.59344 -42.26699 -6.13687  1.000 51.79754  ? 61  LYS A CG   1 
ATOM   892  C CD   . LYS A 1 61  ? -19.29494 -42.23178 -6.92081  1.000 54.07699  ? 61  LYS A CD   1 
ATOM   893  C CE   . LYS A 1 61  ? -18.93008 -40.80630 -7.29863  1.000 51.74057  ? 61  LYS A CE   1 
ATOM   894  N NZ   . LYS A 1 61  ? -17.54317 -40.70844 -7.82758  1.000 51.96136  ? 61  LYS A NZ   1 
ATOM   895  H H    . LYS A 1 61  ? -23.05623 -43.59760 -7.20345  1.000 63.05814  ? 61  LYS A H    1 
ATOM   896  H HA   . LYS A 1 61  ? -20.63263 -44.77622 -7.43482  1.000 67.40816  ? 61  LYS A HA   1 
ATOM   897  H HB2  . LYS A 1 61  ? -21.69373 -43.61462 -5.08694  1.000 67.42950  ? 61  LYS A HB2  1 
ATOM   898  H HB3  . LYS A 1 61  ? -20.18613 -44.07153 -5.29614  1.000 67.42950  ? 61  LYS A HB3  1 
ATOM   899  H HG2  . LYS A 1 61  ? -21.29638 -41.90284 -6.69739  1.000 62.89312  ? 61  LYS A HG2  1 
ATOM   900  H HG3  . LYS A 1 61  ? -20.48420 -41.71919 -5.34385  1.000 62.89312  ? 61  LYS A HG3  1 
ATOM   901  H HD2  . LYS A 1 61  ? -18.57934 -42.59907 -6.37866  1.000 65.62846  ? 61  LYS A HD2  1 
ATOM   902  H HD3  . LYS A 1 61  ? -19.39396 -42.75000 -7.73477  1.000 65.62846  ? 61  LYS A HD3  1 
ATOM   903  H HE2  . LYS A 1 61  ? -19.53911 -40.49204 -7.98508  1.000 62.82475  ? 61  LYS A HE2  1 
ATOM   904  H HE3  . LYS A 1 61  ? -18.99542 -40.24104 -6.51307  1.000 62.82475  ? 61  LYS A HE3  1 
ATOM   905  H HZ1  . LYS A 1 61  ? -17.43038 -39.92993 -8.24385  1.000 63.08970  ? 61  LYS A HZ1  1 
ATOM   906  H HZ2  . LYS A 1 61  ? -16.95785 -40.76628 -7.15962  1.000 63.08970  ? 61  LYS A HZ2  1 
ATOM   907  H HZ3  . LYS A 1 61  ? -17.38989 -41.36904 -8.40395  1.000 63.08970  ? 61  LYS A HZ3  1 
ATOM   908  N N    . SER A 1 62  ? -20.97651 -46.86886 -6.16856  1.000 69.51107  ? 62  SER A N    1 
ATOM   909  C CA   . SER A 1 62  ? -21.22056 -48.13620 -5.49689  1.000 69.23584  ? 62  SER A CA   1 
ATOM   910  C C    . SER A 1 62  ? -20.22839 -48.28847 -4.34915  1.000 67.98940  ? 62  SER A C    1 
ATOM   911  O O    . SER A 1 62  ? -19.23872 -47.55737 -4.25069  1.000 65.96145  ? 62  SER A O    1 
ATOM   912  C CB   . SER A 1 62  ? -21.09701 -49.31792 -6.46604  1.000 66.96675  ? 62  SER A CB   1 
ATOM   913  O OG   . SER A 1 62  ? -21.92681 -49.14557 -7.60018  1.000 65.26041  ? 62  SER A OG   1 
ATOM   914  H H    . SER A 1 62  ? -20.17541 -46.79743 -6.47308  1.000 84.14935  ? 62  SER A H    1 
ATOM   915  H HA   . SER A 1 62  ? -22.12148 -48.14348 -5.13745  1.000 83.81908  ? 62  SER A HA   1 
ATOM   916  H HB2  . SER A 1 62  ? -20.17516 -49.38730 -6.75978  1.000 81.09617  ? 62  SER A HB2  1 
ATOM   917  H HB3  . SER A 1 62  ? -21.36044 -50.12991 -6.00541  1.000 81.09617  ? 62  SER A HB3  1 
ATOM   918  H HG   . SER A 1 62  ? -21.54774 -48.64766 -8.16053  1.000 79.04856  ? 62  SER A HG   1 
ATOM   919  N N    . ASN A 1 63  ? -20.50144 -49.26301 -3.47837  1.000 68.81334  ? 63  ASN A N    1 
ATOM   920  C CA   . ASN A 1 63  ? -19.64872 -49.47774 -2.31351  1.000 68.25703  ? 63  ASN A CA   1 
ATOM   921  C C    . ASN A 1 63  ? -18.17792 -49.56463 -2.70176  1.000 66.87238  ? 63  ASN A C    1 
ATOM   922  O O    . ASN A 1 63  ? -17.30980 -49.03641 -1.99613  1.000 68.78702  ? 63  ASN A O    1 
ATOM   923  C CB   . ASN A 1 63  ? -20.08046 -50.74906 -1.57711  1.000 67.57864  ? 63  ASN A CB   1 
ATOM   924  C CG   . ASN A 1 63  ? -21.47020 -50.63344 -0.97722  1.000 68.91237  ? 63  ASN A CG   1 
ATOM   925  O OD1  . ASN A 1 63  ? -21.89844 -49.54967 -0.57984  1.000 66.98807  ? 63  ASN A OD1  1 
ATOM   926  N ND2  . ASN A 1 63  ? -22.17968 -51.75371 -0.90458  1.000 69.11947  ? 63  ASN A ND2  1 
ATOM   927  H H    . ASN A 1 63  ? -21.16587 -49.80557 -3.53972  1.000 83.31208  ? 63  ASN A H    1 
ATOM   928  H HA   . ASN A 1 63  ? -19.75383 -48.72506 -1.71075  1.000 82.64451  ? 63  ASN A HA   1 
ATOM   929  H HB2  . ASN A 1 63  ? -20.08366 -51.49111 -2.20181  1.000 81.83043  ? 63  ASN A HB2  1 
ATOM   930  H HB3  . ASN A 1 63  ? -19.45572 -50.92495 -0.85623  1.000 81.83043  ? 63  ASN A HB3  1 
ATOM   931  H HD21 . ASN A 1 63  ? -22.97285 -51.73960 -0.57248  1.000 83.67943  ? 63  ASN A HD21 1 
ATOM   932  H HD22 . ASN A 1 63  ? -21.84596 -52.49328 -1.18964  1.000 83.67943  ? 63  ASN A HD22 1 
ATOM   933  N N    . HIS A 1 64  ? -17.87746 -50.21537 -3.82834  1.000 66.97841  ? 64  HIS A N    1 
ATOM   934  C CA   . HIS A 1 64  ? -16.48793 -50.41764 -4.21926  1.000 66.52613  ? 64  HIS A CA   1 
ATOM   935  C C    . HIS A 1 64  ? -15.80846 -49.13583 -4.68655  1.000 65.03681  ? 64  HIS A C    1 
ATOM   936  O O    . HIS A 1 64  ? -14.58225 -49.13049 -4.84577  1.000 64.47171  ? 64  HIS A O    1 
ATOM   937  C CB   . HIS A 1 64  ? -16.39779 -51.48707 -5.31405  1.000 66.10288  ? 64  HIS A CB   1 
ATOM   938  C CG   . HIS A 1 64  ? -17.05188 -51.10249 -6.60527  1.000 66.61804  ? 64  HIS A CG   1 
ATOM   939  N ND1  . HIS A 1 64  ? -16.49623 -50.19440 -7.48022  1.000 66.93241  ? 64  HIS A ND1  1 
ATOM   940  C CD2  . HIS A 1 64  ? -18.20770 -51.51658 -7.17626  1.000 71.17575  ? 64  HIS A CD2  1 
ATOM   941  C CE1  . HIS A 1 64  ? -17.28633 -50.05837 -8.53000  1.000 66.85592  ? 64  HIS A CE1  1 
ATOM   942  N NE2  . HIS A 1 64  ? -18.33186 -50.84945 -8.37013  1.000 67.78901  ? 64  HIS A NE2  1 
ATOM   943  H H    . HIS A 1 64  ? -18.45494 -50.54399 -4.37435  1.000 81.11016  ? 64  HIS A H    1 
ATOM   944  H HA   . HIS A 1 64  ? -15.99717 -50.74268 -3.44828  1.000 80.56742  ? 64  HIS A HA   1 
ATOM   945  H HB2  . HIS A 1 64  ? -15.46201 -51.66266 -5.49949  1.000 80.05952  ? 64  HIS A HB2  1 
ATOM   946  H HB3  . HIS A 1 64  ? -16.82995 -52.29466 -4.99477  1.000 80.05952  ? 64  HIS A HB3  1 
ATOM   947  H HD2  . HIS A 1 64  ? -18.80553 -52.13668 -6.82557  1.000 86.14697  ? 64  HIS A HD2  1 
ATOM   948  H HE1  . HIS A 1 64  ? -17.13256 -49.50040 -9.25796  1.000 80.96317  ? 64  HIS A HE1  1 
ATOM   949  H HE2  . HIS A 1 64  ? -18.98451 -50.93318 -8.92388  1.000 82.08288  ? 64  HIS A HE2  1 
ATOM   950  N N    . ASN A 1 65  ? -16.56171 -48.05502 -4.90109  1.000 66.16301  ? 65  ASN A N    1 
ATOM   951  C CA   . ASN A 1 65  ? -15.97181 -46.78471 -5.30563  1.000 65.16946  ? 65  ASN A CA   1 
ATOM   952  C C    . ASN A 1 65  ? -15.44585 -45.96981 -4.13006  1.000 64.64775  ? 65  ASN A C    1 
ATOM   953  O O    . ASN A 1 65  ? -14.81442 -44.93080 -4.35373  1.000 61.84114  ? 65  ASN A O    1 
ATOM   954  C CB   . ASN A 1 65  ? -16.99697 -45.94250 -6.07522  1.000 65.41383  ? 65  ASN A CB   1 
ATOM   955  C CG   . ASN A 1 65  ? -17.43906 -46.59771 -7.37116  1.000 67.82343  ? 65  ASN A CG   1 
ATOM   956  O OD1  . ASN A 1 65  ? -18.60398 -46.96073 -7.53025  1.000 69.62100  ? 65  ASN A OD1  1 
ATOM   957  N ND2  . ASN A 1 65  ? -16.51071 -46.73875 -8.31068  1.000 70.06407  ? 65  ASN A ND2  1 
ATOM   958  H H    . ASN A 1 65  ? -17.41747 -48.03478 -4.81817  1.000 80.13169  ? 65  ASN A H    1 
ATOM   959  H HA   . ASN A 1 65  ? -15.22849 -46.97352 -5.89954  1.000 78.93943  ? 65  ASN A HA   1 
ATOM   960  H HB2  . ASN A 1 65  ? -17.78221 -45.81512 -5.52018  1.000 79.23266  ? 65  ASN A HB2  1 
ATOM   961  H HB3  . ASN A 1 65  ? -16.60156 -45.08385 -6.29265  1.000 79.23266  ? 65  ASN A HB3  1 
ATOM   962  H HD21 . ASN A 1 65  ? -16.71203 -47.10419 -9.06269  1.000 84.81295  ? 65  ASN A HD21 1 
ATOM   963  H HD22 . ASN A 1 65  ? -15.70834 -46.46462 -8.16694  1.000 84.81295  ? 65  ASN A HD22 1 
ATOM   964  N N    . PHE A 1 66  ? -15.69201 -46.40603 -2.89691  1.000 62.27582  ? 66  PHE A N    1 
ATOM   965  C CA   . PHE A 1 66  ? -15.30062 -45.67276 -1.69853  1.000 62.33468  ? 66  PHE A CA   1 
ATOM   966  C C    . PHE A 1 66  ? -14.11689 -46.37566 -1.04734  1.000 61.77333  ? 66  PHE A C    1 
ATOM   967  O O    . PHE A 1 66  ? -14.24677 -47.51064 -0.57622  1.000 62.81146  ? 66  PHE A O    1 
ATOM   968  C CB   . PHE A 1 66  ? -16.47402 -45.56037 -0.72323  1.000 62.52588  ? 66  PHE A CB   1 
ATOM   969  C CG   . PHE A 1 66  ? -17.58900 -44.67618 -1.21416  1.000 60.91564  ? 66  PHE A CG   1 
ATOM   970  C CD1  . PHE A 1 66  ? -17.46759 -43.29741 -1.16301  1.000 60.49664  ? 66  PHE A CD1  1 
ATOM   971  C CD2  . PHE A 1 66  ? -18.75889 -45.22198 -1.72033  1.000 62.88648  ? 66  PHE A CD2  1 
ATOM   972  C CE1  . PHE A 1 66  ? -18.48753 -42.47959 -1.61137  1.000 58.38883  ? 66  PHE A CE1  1 
ATOM   973  C CE2  . PHE A 1 66  ? -19.78322 -44.40682 -2.16997  1.000 61.10263  ? 66  PHE A CE2  1 
ATOM   974  C CZ   . PHE A 1 66  ? -19.64611 -43.03425 -2.11416  1.000 58.77151  ? 66  PHE A CZ   1 
ATOM   975  H H    . PHE A 1 66  ? -16.09621 -47.14558 -2.72574  1.000 75.46705  ? 66  PHE A H    1 
ATOM   976  H HA   . PHE A 1 66  ? -15.01932 -44.77734 -1.94346  1.000 75.53768  ? 66  PHE A HA   1 
ATOM   977  H HB2  . PHE A 1 66  ? -16.84185 -46.44555 -0.57470  1.000 75.76712  ? 66  PHE A HB2  1 
ATOM   978  H HB3  . PHE A 1 66  ? -16.14996 -45.19114 0.11317   1.000 75.76712  ? 66  PHE A HB3  1 
ATOM   979  H HD1  . PHE A 1 66  ? -16.69007 -42.91721 -0.82271  1.000 73.33204  ? 66  PHE A HD1  1 
ATOM   980  H HD2  . PHE A 1 66  ? -18.85639 -46.14609 -1.75812  1.000 76.19985  ? 66  PHE A HD2  1 
ATOM   981  H HE1  . PHE A 1 66  ? -18.39271 -41.55518 -1.57408  1.000 70.80266  ? 66  PHE A HE1  1 
ATOM   982  H HE2  . PHE A 1 66  ? -20.56295 -44.78334 -2.50930  1.000 74.05923  ? 66  PHE A HE2  1 
ATOM   983  H HZ   . PHE A 1 66  ? -20.33345 -42.48470 -2.41493  1.000 71.26188  ? 66  PHE A HZ   1 
ATOM   984  N N    . LEU A 1 67  ? -12.97053 -45.69163 -1.01436  1.000 60.02055  ? 67  LEU A N    1 
ATOM   985  C CA   . LEU A 1 67  ? -11.72096 -46.25801 -0.50807  1.000 61.08608  ? 67  LEU A CA   1 
ATOM   986  C C    . LEU A 1 67  ? -11.43247 -45.68426 0.87455   1.000 61.54225  ? 67  LEU A C    1 
ATOM   987  O O    . LEU A 1 67  ? -10.89249 -44.58422 1.00409   1.000 55.76677  ? 67  LEU A O    1 
ATOM   988  C CB   . LEU A 1 67  ? -10.57689 -45.96372 -1.47561  1.000 61.19605  ? 67  LEU A CB   1 
ATOM   989  H H    . LEU A 1 67  ? -12.89155 -44.87959 -1.28630  1.000 72.76073  ? 67  LEU A H    1 
ATOM   990  H HA   . LEU A 1 67  ? -11.82809 -47.21758 -0.41506  1.000 74.03936  ? 67  LEU A HA   1 
ATOM   991  N N    . VAL A 1 68  ? -11.77183 -46.44726 1.91237   1.000 65.15234  ? 68  VAL A N    1 
ATOM   992  C CA   . VAL A 1 68  ? -11.51050 -46.06753 3.29675   1.000 63.14934  ? 68  VAL A CA   1 
ATOM   993  C C    . VAL A 1 68  ? -10.23396 -46.75633 3.75838   1.000 65.45623  ? 68  VAL A C    1 
ATOM   994  O O    . VAL A 1 68  ? -10.08236 -47.97382 3.59457   1.000 68.12219  ? 68  VAL A O    1 
ATOM   995  C CB   . VAL A 1 68  ? -12.69038 -46.44065 4.21152   1.000 67.19906  ? 68  VAL A CB   1 
ATOM   996  C CG1  . VAL A 1 68  ? -12.40480 -46.01426 5.64808   1.000 62.41273  ? 68  VAL A CG1  1 
ATOM   997  C CG2  . VAL A 1 68  ? -13.98062 -45.81726 3.70117   1.000 61.22265  ? 68  VAL A CG2  1 
ATOM   998  H H    . VAL A 1 68  ? -12.16450 -47.20857 1.83609   1.000 78.91887  ? 68  VAL A H    1 
ATOM   999  H HA   . VAL A 1 68  ? -11.37697 -45.10781 3.34154   1.000 76.51528  ? 68  VAL A HA   1 
ATOM   1000 H HB   . VAL A 1 68  ? -12.80485 -47.40384 4.20358   1.000 81.37495  ? 68  VAL A HB   1 
ATOM   1001 H HG11 . VAL A 1 68  ? -13.23012 -46.04552 6.15677   1.000 75.63134  ? 68  VAL A HG11 1 
ATOM   1002 H HG12 . VAL A 1 68  ? -11.75483 -46.62178 6.03454   1.000 75.63134  ? 68  VAL A HG12 1 
ATOM   1003 H HG13 . VAL A 1 68  ? -12.05210 -45.11066 5.64511   1.000 75.63134  ? 68  VAL A HG13 1 
ATOM   1004 H HG21 . VAL A 1 68  ? -14.66845 -45.91627 4.37791   1.000 74.20324  ? 68  VAL A HG21 1 
ATOM   1005 H HG22 . VAL A 1 68  ? -13.82709 -44.87664 3.52071   1.000 74.20324  ? 68  VAL A HG22 1 
ATOM   1006 H HG23 . VAL A 1 68  ? -14.24993 -46.27061 2.88701   1.000 74.20324  ? 68  VAL A HG23 1 
ATOM   1007 N N    . GLN A 1 69  ? -9.31949  -45.98688 4.34934   1.000 63.18760  ? 69  GLN A N    1 
ATOM   1008 C CA   . GLN A 1 69  ? -8.02798  -46.50030 4.80181   1.000 65.93713  ? 69  GLN A CA   1 
ATOM   1009 C C    . GLN A 1 69  ? -7.75596  -46.00220 6.21653   1.000 63.54847  ? 69  GLN A C    1 
ATOM   1010 O O    . GLN A 1 69  ? -7.57526  -44.79860 6.43198   1.000 59.69993  ? 69  GLN A O    1 
ATOM   1011 C CB   . GLN A 1 69  ? -6.90806  -46.07644 3.85427   1.000 67.03121  ? 69  GLN A CB   1 
ATOM   1012 H H    . GLN A 1 69  ? -9.42732  -45.14740 4.50179   1.000 76.56118  ? 69  GLN A H    1 
ATOM   1013 H HA   . GLN A 1 69  ? -8.06824  -47.46905 4.83010   1.000 79.86062  ? 69  GLN A HA   1 
ATOM   1014 N N    . ALA A 1 70  ? -7.70448  -46.92972 7.17383   1.000 67.10461  ? 70  ALA A N    1 
ATOM   1015 C CA   . ALA A 1 70  ? -7.39080  -46.61970 8.56923   1.000 64.31127  ? 70  ALA A CA   1 
ATOM   1016 C C    . ALA A 1 70  ? -5.91534  -46.93739 8.79396   1.000 68.82038  ? 70  ALA A C    1 
ATOM   1017 O O    . ALA A 1 70  ? -5.54499  -48.06423 9.12776   1.000 70.53730  ? 70  ALA A O    1 
ATOM   1018 C CB   . ALA A 1 70  ? -8.28538  -47.40725 9.51924   1.000 65.11240  ? 70  ALA A CB   1 
ATOM   1019 H H    . ALA A 1 70  ? -7.85116  -47.76580 7.03580   1.000 81.26159  ? 70  ALA A H    1 
ATOM   1020 H HA   . ALA A 1 70  ? -7.53489  -45.67338 8.72612   1.000 77.90959  ? 70  ALA A HA   1 
ATOM   1021 H HB1  . ALA A 1 70  ? -8.07735  -47.15358 10.43208  1.000 78.87095  ? 70  ALA A HB1  1 
ATOM   1022 H HB2  . ALA A 1 70  ? -9.21285  -47.20257 9.32223   1.000 78.87095  ? 70  ALA A HB2  1 
ATOM   1023 H HB3  . ALA A 1 70  ? -8.12202  -48.35515 9.39393   1.000 78.87095  ? 70  ALA A HB3  1 
ATOM   1024 N N    . GLY A 1 71  ? -5.06752  -45.92808 8.61645   1.000 66.85208  ? 71  GLY A N    1 
ATOM   1025 C CA   . GLY A 1 71  ? -3.63591  -46.14003 8.67583   1.000 66.69568  ? 71  GLY A CA   1 
ATOM   1026 C C    . GLY A 1 71  ? -3.17624  -47.08791 7.58812   1.000 69.75430  ? 71  GLY A C    1 
ATOM   1027 O O    . GLY A 1 71  ? -2.92794  -46.66655 6.45417   1.000 70.88335  ? 71  GLY A O    1 
ATOM   1028 H H    . GLY A 1 71  ? -5.30090  -45.11510 8.46088   1.000 80.95856  ? 71  GLY A H    1 
ATOM   1029 H HA2  . GLY A 1 71  ? -3.17670  -45.29292 8.56431   1.000 80.77088  ? 71  GLY A HA2  1 
ATOM   1030 H HA3  . GLY A 1 71  ? -3.39830  -46.51703 9.53741   1.000 80.77088  ? 71  GLY A HA3  1 
ATOM   1031 N N    . ASN A 1 72  ? -3.07003  -48.37454 7.91841   1.000 72.45328  ? 72  ASN A N    1 
ATOM   1032 C CA   . ASN A 1 72  ? -2.73878  -49.40156 6.94315   1.000 73.61250  ? 72  ASN A CA   1 
ATOM   1033 C C    . ASN A 1 72  ? -3.86995  -50.39549 6.71572   1.000 77.10501  ? 72  ASN A C    1 
ATOM   1034 O O    . ASN A 1 72  ? -3.82621  -51.14131 5.72996   1.000 79.20369  ? 72  ASN A O    1 
ATOM   1035 C CB   . ASN A 1 72  ? -1.47864  -50.16585 7.37621   1.000 71.16607  ? 72  ASN A CB   1 
ATOM   1036 H H    . ASN A 1 72  ? -3.18778  -48.67831 8.71431   1.000 87.68000  ? 72  ASN A H    1 
ATOM   1037 H HA   . ASN A 1 72  ? -2.54317  -48.97152 6.09598   1.000 89.07107  ? 72  ASN A HA   1 
ATOM   1038 N N    . VAL A 1 73  ? -4.87108  -50.43606 7.59104   1.000 77.91305  ? 73  VAL A N    1 
ATOM   1039 C CA   . VAL A 1 73  ? -5.98454  -51.36913 7.45135   1.000 81.16847  ? 73  VAL A CA   1 
ATOM   1040 C C    . VAL A 1 73  ? -6.98236  -50.77730 6.46098   1.000 81.32306  ? 73  VAL A C    1 
ATOM   1041 O O    . VAL A 1 73  ? -7.64690  -49.78086 6.75503   1.000 80.96842  ? 73  VAL A O    1 
ATOM   1042 C CB   . VAL A 1 73  ? -6.64879  -51.65366 8.80303   1.000 89.87944  ? 73  VAL A CB   1 
ATOM   1043 H H    . VAL A 1 73  ? -4.92874  -49.92740 8.28209   1.000 94.23173  ? 73  VAL A H    1 
ATOM   1044 H HA   . VAL A 1 73  ? -5.65504  -52.20580 7.08761   1.000 98.13823  ? 73  VAL A HA   1 
ATOM   1045 N N    . GLN A 1 74  ? -7.08752  -51.39123 5.28335   1.000 85.04126  ? 74  GLN A N    1 
ATOM   1046 C CA   . GLN A 1 74  ? -8.04992  -50.96566 4.27270   1.000 79.60486  ? 74  GLN A CA   1 
ATOM   1047 C C    . GLN A 1 74  ? -9.40450  -51.57770 4.61557   1.000 79.15963  ? 74  GLN A C    1 
ATOM   1048 O O    . GLN A 1 74  ? -9.56537  -52.80204 4.57707   1.000 80.19650  ? 74  GLN A O    1 
ATOM   1049 C CB   . GLN A 1 74  ? -7.60411  -51.39694 2.87839   1.000 82.86231  ? 74  GLN A CB   1 
ATOM   1050 C CG   . GLN A 1 74  ? -6.11279  -51.27538 2.61030   1.000 80.78196  ? 74  GLN A CG   1 
ATOM   1051 C CD   . GLN A 1 74  ? -5.63594  -49.84080 2.54994   1.000 79.72743  ? 74  GLN A CD   1 
ATOM   1052 O OE1  . GLN A 1 74  ? -5.48826  -49.26744 1.47033   1.000 82.24136  ? 74  GLN A OE1  1 
ATOM   1053 N NE2  . GLN A 1 74  ? -5.38750  -49.25212 3.71381   1.000 78.37708  ? 74  GLN A NE2  1 
ATOM   1054 H H    . GLN A 1 74  ? -6.60715  -52.06349 5.04478   1.000 102.78558 ? 74  GLN A H    1 
ATOM   1055 H HA   . GLN A 1 74  ? -8.11847  -49.99813 4.28171   1.000 96.26190  ? 74  GLN A HA   1 
ATOM   1056 H HB2  . GLN A 1 74  ? -7.84640  -52.32786 2.75358   1.000 100.17085 ? 74  GLN A HB2  1 
ATOM   1057 H HB3  . GLN A 1 74  ? -8.06219  -50.84453 2.22577   1.000 100.17085 ? 74  GLN A HB3  1 
ATOM   1058 H HG2  . GLN A 1 74  ? -5.62759  -51.72158 3.32191   1.000 97.67442  ? 74  GLN A HG2  1 
ATOM   1059 H HG3  . GLN A 1 74  ? -5.91095  -51.69317 1.75848   1.000 97.67442  ? 74  GLN A HG3  1 
ATOM   1060 H HE21 . GLN A 1 74  ? -5.49993  -49.68598 4.44779   1.000 94.78857  ? 74  GLN A HE21 1 
ATOM   1061 H HE22 . GLN A 1 74  ? -5.11414  -48.43697 3.73369   1.000 94.78857  ? 74  GLN A HE22 1 
ATOM   1062 N N    . LEU A 1 75  ? -10.38065 -50.74020 4.95036   1.000 75.90723  ? 75  LEU A N    1 
ATOM   1063 C CA   . LEU A 1 75  ? -11.69556 -51.24336 5.31883   1.000 75.50939  ? 75  LEU A CA   1 
ATOM   1064 C C    . LEU A 1 75  ? -12.51909 -51.54284 4.06961   1.000 77.35058  ? 75  LEU A C    1 
ATOM   1065 O O    . LEU A 1 75  ? -12.39460 -50.87355 3.03915   1.000 78.07173  ? 75  LEU A O    1 
ATOM   1066 C CB   . LEU A 1 75  ? -12.43198 -50.23646 6.20140   1.000 72.68764  ? 75  LEU A CB   1 
ATOM   1067 C CG   . LEU A 1 75  ? -11.62309 -49.53473 7.29213   1.000 71.27529  ? 75  LEU A CG   1 
ATOM   1068 C CD1  . LEU A 1 75  ? -12.53321 -48.66250 8.15611   1.000 65.12712  ? 75  LEU A CD1  1 
ATOM   1069 C CD2  . LEU A 1 75  ? -10.86569 -50.52573 8.15651   1.000 72.71142  ? 75  LEU A CD2  1 
ATOM   1070 H H    . LEU A 1 75  ? -10.30611 -49.88369 4.97135   1.000 91.82474  ? 75  LEU A H    1 
ATOM   1071 H HA   . LEU A 1 75  ? -11.59732 -52.06520 5.82462   1.000 91.34733  ? 75  LEU A HA   1 
ATOM   1072 H HB2  . LEU A 1 75  ? -12.78933 -49.54239 5.62567   1.000 87.96123  ? 75  LEU A HB2  1 
ATOM   1073 H HB3  . LEU A 1 75  ? -13.15622 -50.70462 6.64549   1.000 87.96123  ? 75  LEU A HB3  1 
ATOM   1074 H HG   . LEU A 1 75  ? -10.96606 -48.96615 6.86095   1.000 86.26642  ? 75  LEU A HG   1 
ATOM   1075 H HD11 . LEU A 1 75  ? -11.98454 -48.08677 8.71145   1.000 78.88862  ? 75  LEU A HD11 1 
ATOM   1076 H HD12 . LEU A 1 75  ? -13.09703 -48.12497 7.57812   1.000 78.88862  ? 75  LEU A HD12 1 
ATOM   1077 H HD13 . LEU A 1 75  ? -13.08225 -49.23504 8.71436   1.000 78.88862  ? 75  LEU A HD13 1 
ATOM   1078 H HD21 . LEU A 1 75  ? -10.35916 -50.03885 8.82530   1.000 87.98977  ? 75  LEU A HD21 1 
ATOM   1079 H HD22 . LEU A 1 75  ? -11.50093 -51.11772 8.58885   1.000 87.98977  ? 75  LEU A HD22 1 
ATOM   1080 H HD23 . LEU A 1 75  ? -10.26413 -51.03930 7.59503   1.000 87.98977  ? 75  LEU A HD23 1 
ATOM   1081 N N    . ARG A 1 76  ? -13.36201 -52.56734 4.17009   1.000 74.60612  ? 76  ARG A N    1 
ATOM   1082 C CA   . ARG A 1 76  ? -14.25316 -52.96725 3.08869   1.000 72.36480  ? 76  ARG A CA   1 
ATOM   1083 C C    . ARG A 1 76  ? -15.62894 -52.35658 3.32279   1.000 70.03207  ? 76  ARG A C    1 
ATOM   1084 O O    . ARG A 1 76  ? -16.18568 -52.47422 4.41938   1.000 67.88044  ? 76  ARG A O    1 
ATOM   1085 C CB   . ARG A 1 76  ? -14.35634 -54.49045 3.00103   1.000 69.49535  ? 76  ARG A CB   1 
ATOM   1086 H H    . ARG A 1 76  ? -13.43660 -53.05723 4.87297   1.000 90.26341  ? 76  ARG A H    1 
ATOM   1087 H HA   . ARG A 1 76  ? -13.90867 -52.64013 2.24298   1.000 87.57383  ? 76  ARG A HA   1 
ATOM   1088 N N    . VAL A 1 77  ? -16.17179 -51.71106 2.29339   1.000 70.09571  ? 77  VAL A N    1 
ATOM   1089 C CA   . VAL A 1 77  ? -17.45293 -51.01897 2.38855   1.000 69.14776  ? 77  VAL A CA   1 
ATOM   1090 C C    . VAL A 1 77  ? -18.56385 -51.96983 1.96583   1.000 71.51100  ? 77  VAL A C    1 
ATOM   1091 O O    . VAL A 1 77  ? -18.48762 -52.59521 0.90132   1.000 68.70053  ? 77  VAL A O    1 
ATOM   1092 C CB   . VAL A 1 77  ? -17.45662 -49.74865 1.51974   1.000 70.90331  ? 77  VAL A CB   1 
ATOM   1093 C CG1  . VAL A 1 77  ? -18.76520 -48.98535 1.69438   1.000 67.70845  ? 77  VAL A CG1  1 
ATOM   1094 C CG2  . VAL A 1 77  ? -16.25498 -48.86972 1.85249   1.000 70.43608  ? 77  VAL A CG2  1 
ATOM   1095 H H    . VAL A 1 77  ? -15.80987 -51.65908 1.51499   1.000 84.85092  ? 77  VAL A H    1 
ATOM   1096 H HA   . VAL A 1 77  ? -17.60696 -50.76253 3.31128   1.000 83.71338  ? 77  VAL A HA   1 
ATOM   1097 H HB   . VAL A 1 77  ? -17.38618 -50.00310 0.58637   1.000 85.82004  ? 77  VAL A HB   1 
ATOM   1098 H HG11 . VAL A 1 77  ? -18.71733 -48.15729 1.19147   1.000 81.98620  ? 77  VAL A HG11 1 
ATOM   1099 H HG12 . VAL A 1 77  ? -19.49575 -49.53126 1.36397   1.000 81.98620  ? 77  VAL A HG12 1 
ATOM   1100 H HG13 . VAL A 1 77  ? -18.89550 -48.79329 2.63621   1.000 81.98620  ? 77  VAL A HG13 1 
ATOM   1101 H HG21 . VAL A 1 77  ? -16.38496 -47.99391 1.45632   1.000 85.25937  ? 77  VAL A HG21 1 
ATOM   1102 H HG22 . VAL A 1 77  ? -16.17998 -48.78900 2.81621   1.000 85.25937  ? 77  VAL A HG22 1 
ATOM   1103 H HG23 . VAL A 1 77  ? -15.45374 -49.28041 1.49160   1.000 85.25937  ? 77  VAL A HG23 1 
ATOM   1104 N N    . ILE A 1 78  ? -19.60623 -52.06691 2.79154   1.000 67.48872  ? 78  ILE A N    1 
ATOM   1105 C CA   . ILE A 1 78  ? -20.70021 -52.99643 2.53678   1.000 67.49129  ? 78  ILE A CA   1 
ATOM   1106 C C    . ILE A 1 78  ? -22.04152 -52.27672 2.60108   1.000 67.92511  ? 78  ILE A C    1 
ATOM   1107 O O    . ILE A 1 78  ? -23.09901 -52.91173 2.68351   1.000 67.12922  ? 78  ILE A O    1 
ATOM   1108 C CB   . ILE A 1 78  ? -20.65474 -54.17233 3.53011   1.000 65.72498  ? 78  ILE A CB   1 
ATOM   1109 C CG1  . ILE A 1 78  ? -20.99462 -53.71377 4.95107   1.000 65.71037  ? 78  ILE A CG1  1 
ATOM   1110 C CG2  . ILE A 1 78  ? -19.26917 -54.81039 3.53347   1.000 67.98835  ? 78  ILE A CG2  1 
ATOM   1111 C CD1  . ILE A 1 78  ? -20.93999 -54.83106 5.99166   1.000 65.36870  ? 78  ILE A CD1  1 
ATOM   1112 H H    . ILE A 1 78  ? -19.70115 -51.60192 3.50874   1.000 81.72253  ? 78  ILE A H    1 
ATOM   1113 H HA   . ILE A 1 78  ? -20.60574 -53.34078 1.63489   1.000 81.72561  ? 78  ILE A HA   1 
ATOM   1114 H HB   . ILE A 1 78  ? -21.31736 -54.81924 3.24142   1.000 79.60604  ? 78  ILE A HB   1 
ATOM   1115 H HG12 . ILE A 1 78  ? -20.36008 -53.03032 5.21781   1.000 79.58851  ? 78  ILE A HG12 1 
ATOM   1116 H HG13 . ILE A 1 78  ? -21.89412 -53.35075 4.95429   1.000 79.58851  ? 78  ILE A HG13 1 
ATOM   1117 H HG21 . ILE A 1 78  ? -19.33159 -55.69892 3.91755   1.000 82.32209  ? 78  ILE A HG21 1 
ATOM   1118 H HG22 . ILE A 1 78  ? -18.94512 -54.86651 2.62093   1.000 82.32209  ? 78  ILE A HG22 1 
ATOM   1119 H HG23 . ILE A 1 78  ? -18.67025 -54.26202 4.06403   1.000 82.32209  ? 78  ILE A HG23 1 
ATOM   1120 H HD11 . ILE A 1 78  ? -21.43895 -54.55610 6.77673   1.000 79.17850  ? 78  ILE A HD11 1 
ATOM   1121 H HD12 . ILE A 1 78  ? -21.33298 -55.63358 5.61427   1.000 79.17850  ? 78  ILE A HD12 1 
ATOM   1122 H HD13 . ILE A 1 78  ? -20.01418 -54.99634 6.22925   1.000 79.17850  ? 78  ILE A HD13 1 
ATOM   1123 N N    . GLY A 1 79  ? -22.00532 -50.95022 2.54862   1.000 67.91529  ? 79  GLY A N    1 
ATOM   1124 C CA   . GLY A 1 79  ? -23.21078 -50.14770 2.59665   1.000 64.06488  ? 79  GLY A CA   1 
ATOM   1125 C C    . GLY A 1 79  ? -22.89454 -48.66866 2.52774   1.000 61.51519  ? 79  GLY A C    1 
ATOM   1126 O O    . GLY A 1 79  ? -21.82103 -48.24165 2.96250   1.000 61.09640  ? 79  GLY A O    1 
ATOM   1127 H H    . GLY A 1 79  ? -21.28286 -50.48815 2.48421   1.000 82.23442  ? 79  GLY A H    1 
ATOM   1128 H HA2  . GLY A 1 79  ? -23.78348 -50.37729 1.84818   1.000 77.61392  ? 79  GLY A HA2  1 
ATOM   1129 H HA3  . GLY A 1 79  ? -23.68574 -50.32478 3.42367   1.000 77.61392  ? 79  GLY A HA3  1 
ATOM   1130 N N    . HIS A 1 80  ? -23.80535 -47.87368 1.97298   1.000 58.93567  ? 80  HIS A N    1 
ATOM   1131 C CA   . HIS A 1 80  ? -23.57499 -46.44244 1.84670   1.000 58.56774  ? 80  HIS A CA   1 
ATOM   1132 C C    . HIS A 1 80  ? -24.91287 -45.72079 1.84684   1.000 57.48074  ? 80  HIS A C    1 
ATOM   1133 O O    . HIS A 1 80  ? -25.89134 -46.19987 1.26639   1.000 55.31554  ? 80  HIS A O    1 
ATOM   1134 C CB   . HIS A 1 80  ? -22.78661 -46.10362 0.57561   1.000 60.60080  ? 80  HIS A CB   1 
ATOM   1135 C CG   . HIS A 1 80  ? -23.57627 -46.24663 -0.68768  1.000 61.52435  ? 80  HIS A CG   1 
ATOM   1136 N ND1  . HIS A 1 80  ? -23.51055 -47.36898 -1.48489  1.000 63.39597  ? 80  HIS A ND1  1 
ATOM   1137 C CD2  . HIS A 1 80  ? -24.44015 -45.40160 -1.29847  1.000 59.23067  ? 80  HIS A CD2  1 
ATOM   1138 C CE1  . HIS A 1 80  ? -24.30494 -47.21180 -2.52909  1.000 63.48191  ? 80  HIS A CE1  1 
ATOM   1139 N NE2  . HIS A 1 80  ? -24.88216 -46.02726 -2.43886  1.000 63.02005  ? 80  HIS A NE2  1 
ATOM   1140 H H    . HIS A 1 80  ? -24.56202 -48.14073 1.66357   1.000 71.45888  ? 80  HIS A H    1 
ATOM   1141 H HA   . HIS A 1 80  ? -23.06236 -46.13158 2.60924   1.000 71.01735  ? 80  HIS A HA   1 
ATOM   1142 H HB2  . HIS A 1 80  ? -22.48561 -45.18327 0.63261   1.000 73.45703  ? 80  HIS A HB2  1 
ATOM   1143 H HB3  . HIS A 1 80  ? -22.02333 -46.69916 0.51526   1.000 73.45703  ? 80  HIS A HB3  1 
ATOM   1144 H HD1  . HIS A 1 80  ? -23.02794 -48.06315 -1.32736  1.000 76.81123  ? 80  HIS A HD1  1 
ATOM   1145 H HD2  . HIS A 1 80  ? -24.68793 -44.55583 -1.00152  1.000 71.81287  ? 80  HIS A HD2  1 
ATOM   1146 H HE1  . HIS A 1 80  ? -24.43539 -47.83007 -3.21146  1.000 76.91436  ? 80  HIS A HE1  1 
ATOM   1147 N N    . SER A 1 81  ? -24.93960 -44.56379 2.49965   1.000 51.22243  ? 81  SER A N    1 
ATOM   1148 C CA   . SER A 1 81  ? -26.15703 -43.78328 2.64401   1.000 48.73249  ? 81  SER A CA   1 
ATOM   1149 C C    . SER A 1 81  ? -25.76691 -42.32220 2.78382   1.000 47.81561  ? 81  SER A C    1 
ATOM   1150 O O    . SER A 1 81  ? -24.62718 -41.99165 3.12004   1.000 44.49527  ? 81  SER A O    1 
ATOM   1151 C CB   . SER A 1 81  ? -26.97645 -44.26106 3.84967   1.000 50.30822  ? 81  SER A CB   1 
ATOM   1152 O OG   . SER A 1 81  ? -28.15499 -43.49776 4.01693   1.000 54.74740  ? 81  SER A OG   1 
ATOM   1153 H H    . SER A 1 81  ? -24.25304 -44.20530 2.87343   1.000 62.20298  ? 81  SER A H    1 
ATOM   1154 H HA   . SER A 1 81  ? -26.71417 -43.87099 1.85483   1.000 59.21506  ? 81  SER A HA   1 
ATOM   1155 H HB2  . SER A 1 81  ? -27.22246 -45.18919 3.71197   1.000 61.10593  ? 81  SER A HB2  1 
ATOM   1156 H HB3  . SER A 1 81  ? -26.43375 -44.17680 4.64921   1.000 61.10593  ? 81  SER A HB3  1 
ATOM   1157 H HG   . SER A 1 81  ? -28.06008 -42.95860 4.65403   1.000 66.43295  ? 81  SER A HG   1 
ATOM   1158 N N    . MET A 1 82  ? -26.72371 -41.44967 2.49483   1.000 41.43990  ? 82  MET A N    1 
ATOM   1159 C CA   . MET A 1 82  ? -26.55086 -40.01155 2.65479   1.000 39.90483  ? 82  MET A CA   1 
ATOM   1160 C C    . MET A 1 82  ? -27.54543 -39.54931 3.71044   1.000 38.90600  ? 82  MET A C    1 
ATOM   1161 O O    . MET A 1 82  ? -28.76108 -39.62882 3.50241   1.000 39.98363  ? 82  MET A O    1 
ATOM   1162 C CB   . MET A 1 82  ? -26.76123 -39.27536 1.33371   1.000 40.05592  ? 82  MET A CB   1 
ATOM   1163 C CG   . MET A 1 82  ? -26.39990 -37.80017 1.39362   1.000 37.71216  ? 82  MET A CG   1 
ATOM   1164 S SD   . MET A 1 82  ? -26.15858 -37.06372 -0.23318  1.000 37.06476  ? 82  MET A SD   1 
ATOM   1165 C CE   . MET A 1 82  ? -27.81060 -37.14291 -0.92193  1.000 42.83173  ? 82  MET A CE   1 
ATOM   1166 H H    . MET A 1 82  ? -27.49958 -41.67181 2.19771   1.000 50.46395  ? 82  MET A H    1 
ATOM   1167 H HA   . MET A 1 82  ? -25.64662 -39.82307 2.95098   1.000 48.62187  ? 82  MET A HA   1 
ATOM   1168 H HB2  . MET A 1 82  ? -26.20669 -39.68920 0.65392   1.000 48.80317  ? 82  MET A HB2  1 
ATOM   1169 H HB3  . MET A 1 82  ? -27.69637 -39.34182 1.08471   1.000 48.80317  ? 82  MET A HB3  1 
ATOM   1170 H HG2  . MET A 1 82  ? -27.11634 -37.31849 1.83588   1.000 45.99066  ? 82  MET A HG2  1 
ATOM   1171 H HG3  . MET A 1 82  ? -25.57433 -37.69849 1.89260   1.000 45.99066  ? 82  MET A HG3  1 
ATOM   1172 H HE1  . MET A 1 82  ? -27.84573 -36.59568 -1.72205  1.000 52.13415  ? 82  MET A HE1  1 
ATOM   1173 H HE2  . MET A 1 82  ? -28.01701 -38.06472 -1.14231  1.000 52.13415  ? 82  MET A HE2  1 
ATOM   1174 H HE3  . MET A 1 82  ? -28.44264 -36.81022 -0.26562  1.000 52.13415  ? 82  MET A HE3  1 
ATOM   1175 N N    . GLN A 1 83  ? -27.03242 -39.09675 4.84787   1.000 37.79387  ? 83  GLN A N    1 
ATOM   1176 C CA   . GLN A 1 83  ? -27.83363 -38.44907 5.87894   1.000 36.53003  ? 83  GLN A CA   1 
ATOM   1177 C C    . GLN A 1 83  ? -27.51977 -36.95812 5.81359   1.000 34.88867  ? 83  GLN A C    1 
ATOM   1178 O O    . GLN A 1 83  ? -26.40887 -36.53922 6.16328   1.000 32.43607  ? 83  GLN A O    1 
ATOM   1179 C CB   . GLN A 1 83  ? -27.53263 -39.01579 7.26204   1.000 39.03846  ? 83  GLN A CB   1 
ATOM   1180 C CG   . GLN A 1 83  ? -28.15144 -38.20490 8.38751   1.000 39.95443  ? 83  GLN A CG   1 
ATOM   1181 C CD   . GLN A 1 83  ? -28.05908 -38.89723 9.73438   1.000 41.26857  ? 83  GLN A CD   1 
ATOM   1182 O OE1  . GLN A 1 83  ? -27.15711 -39.70029 9.97847   1.000 41.01935  ? 83  GLN A OE1  1 
ATOM   1183 N NE2  . GLN A 1 83  ? -29.00108 -38.59081 10.61777  1.000 42.62949  ? 83  GLN A NE2  1 
ATOM   1184 H H    . GLN A 1 83  ? -26.19875 -39.15518 5.05080   1.000 46.08872  ? 83  GLN A H    1 
ATOM   1185 H HA   . GLN A 1 83  ? -28.77689 -38.59258 5.70413   1.000 44.57210  ? 83  GLN A HA   1 
ATOM   1186 H HB2  . GLN A 1 83  ? -27.88489 -39.91799 7.31528   1.000 47.58221  ? 83  GLN A HB2  1 
ATOM   1187 H HB3  . GLN A 1 83  ? -26.57183 -39.02640 7.39486   1.000 47.58221  ? 83  GLN A HB3  1 
ATOM   1188 H HG2  . GLN A 1 83  ? -27.68867 -37.35512 8.45548   1.000 48.68138  ? 83  GLN A HG2  1 
ATOM   1189 H HG3  . GLN A 1 83  ? -29.08969 -38.05692 8.19081   1.000 48.68138  ? 83  GLN A HG3  1 
ATOM   1190 H HE21 . GLN A 1 83  ? -29.61749 -38.02780 10.41123  1.000 51.89145  ? 83  GLN A HE21 1 
ATOM   1191 H HE22 . GLN A 1 83  ? -28.99503 -38.95527 11.39670  1.000 51.89145  ? 83  GLN A HE22 1 
ATOM   1192 N N    . ASN A 1 84  ? -28.48920 -36.15951 5.35829   1.000 32.81161  ? 84  ASN A N    1 
ATOM   1193 C CA   . ASN A 1 84  ? -28.26488 -34.72342 5.22526   1.000 31.42669  ? 84  ASN A CA   1 
ATOM   1194 C C    . ASN A 1 84  ? -26.96736 -34.50270 4.45949   1.000 30.36668  ? 84  ASN A C    1 
ATOM   1195 O O    . ASN A 1 84  ? -26.83466 -34.98106 3.32819   1.000 32.02783  ? 84  ASN A O    1 
ATOM   1196 C CB   . ASN A 1 84  ? -28.26614 -34.08215 6.60304   1.000 30.57445  ? 84  ASN A CB   1 
ATOM   1197 C CG   . ASN A 1 84  ? -29.58560 -34.29545 7.32560   1.000 33.72865  ? 84  ASN A CG   1 
ATOM   1198 O OD1  . ASN A 1 84  ? -30.65688 -34.01957 6.78278   1.000 32.62349  ? 84  ASN A OD1  1 
ATOM   1199 N ND2  . ASN A 1 84  ? -29.51608 -34.81937 8.54366   1.000 36.35116  ? 84  ASN A ND2  1 
ATOM   1200 H H    . ASN A 1 84  ? -29.27325 -36.42401 5.12395   1.000 40.11000  ? 84  ASN A H    1 
ATOM   1201 H HA   . ASN A 1 84  ? -28.97172 -34.28642 4.72496   1.000 38.44810  ? 84  ASN A HA   1 
ATOM   1202 H HB2  . ASN A 1 84  ? -27.55949 -34.47504 7.13893   1.000 37.42541  ? 84  ASN A HB2  1 
ATOM   1203 H HB3  . ASN A 1 84  ? -28.12110 -33.12746 6.51120   1.000 37.42541  ? 84  ASN A HB3  1 
ATOM   1204 H HD21 . ASN A 1 84  ? -30.23571 -34.95935 8.99325   1.000 44.35747  ? 84  ASN A HD21 1 
ATOM   1205 H HD22 . ASN A 1 84  ? -28.75142 -35.01872 8.88300   1.000 44.35747  ? 84  ASN A HD22 1 
ATOM   1206 N N    . CYS A 1 85  ? -25.99703 -33.81100 5.04637   1.000 29.33562  ? 85  CYS A N    1 
ATOM   1207 C CA   . CYS A 1 85  ? -24.77415 -33.48568 4.32329   1.000 28.32656  ? 85  CYS A CA   1 
ATOM   1208 C C    . CYS A 1 85  ? -23.60771 -34.41247 4.64094   1.000 30.62568  ? 85  CYS A C    1 
ATOM   1209 O O    . CYS A 1 85  ? -22.47385 -34.10447 4.25558   1.000 32.28275  ? 85  CYS A O    1 
ATOM   1210 C CB   . CYS A 1 85  ? -24.37931 -32.02935 4.59667   1.000 29.00181  ? 85  CYS A CB   1 
ATOM   1211 S SG   . CYS A 1 85  ? -25.49186 -30.81662 3.84350   1.000 24.04503  ? 85  CYS A SG   1 
ATOM   1212 H H    . CYS A 1 85  ? -26.02404 -33.52177 5.85582   1.000 35.93881  ? 85  CYS A H    1 
ATOM   1213 H HA   . CYS A 1 85  ? -24.95536 -33.58104 3.37515   1.000 34.72794  ? 85  CYS A HA   1 
ATOM   1214 H HB2  . CYS A 1 85  ? -24.38394 -31.88006 5.55510   1.000 35.53824  ? 85  CYS A HB2  1 
ATOM   1215 H HB3  . CYS A 1 85  ? -23.48991 -31.87583 4.24129   1.000 35.53824  ? 85  CYS A HB3  1 
ATOM   1216 H HG   . CYS A 1 85  ? -25.02220 -29.72034 3.97611   1.000 29.59011  ? 85  CYS A HG   1 
ATOM   1217 N N    . VAL A 1 86  ? -23.85201 -35.54663 5.30076   1.000 30.97545  ? 86  VAL A N    1 
ATOM   1218 C CA   . VAL A 1 86  ? -22.78735 -36.49947 5.58405   1.000 30.88714  ? 86  VAL A CA   1 
ATOM   1219 C C    . VAL A 1 86  ? -23.10370 -37.84534 4.94311   1.000 33.90485  ? 86  VAL A C    1 
ATOM   1220 O O    . VAL A 1 86  ? -24.26653 -38.24510 4.81390   1.000 35.43645  ? 86  VAL A O    1 
ATOM   1221 C CB   . VAL A 1 86  ? -22.53865 -36.70249 7.09921   1.000 31.94689  ? 86  VAL A CB   1 
ATOM   1222 C CG1  . VAL A 1 86  ? -22.08436 -35.40677 7.74603   1.000 32.81944  ? 86  VAL A CG1  1 
ATOM   1223 C CG2  . VAL A 1 86  ? -23.78140 -37.25783 7.78297   1.000 32.43058  ? 86  VAL A CG2  1 
ATOM   1224 H H    . VAL A 1 86  ? -24.62616 -35.78202 5.59212   1.000 37.90661  ? 86  VAL A H    1 
ATOM   1225 H HA   . VAL A 1 86  ? -21.98029 -36.14363 5.18040   1.000 37.80063  ? 86  VAL A HA   1 
ATOM   1226 H HB   . VAL A 1 86  ? -21.82836 -37.35298 7.21432   1.000 39.07233  ? 86  VAL A HB   1 
ATOM   1227 H HG11 . VAL A 1 86  ? -22.22216 -35.46691 8.70431   1.000 40.11939  ? 86  VAL A HG11 1 
ATOM   1228 H HG12 . VAL A 1 86  ? -21.14301 -35.27155 7.55505   1.000 40.11939  ? 86  VAL A HG12 1 
ATOM   1229 H HG13 . VAL A 1 86  ? -22.60435 -34.67305 7.38248   1.000 40.11939  ? 86  VAL A HG13 1 
ATOM   1230 H HG21 . VAL A 1 86  ? -23.61556 -37.32102 8.73660   1.000 39.65277  ? 86  VAL A HG21 1 
ATOM   1231 H HG22 . VAL A 1 86  ? -24.52731 -36.66070 7.61579   1.000 39.65277  ? 86  VAL A HG22 1 
ATOM   1232 H HG23 . VAL A 1 86  ? -23.97426 -38.13718 7.42179   1.000 39.65277  ? 86  VAL A HG23 1 
ATOM   1233 N N    . LEU A 1 87  ? -22.03850 -38.55050 4.55621   1.000 35.66405  ? 87  LEU A N    1 
ATOM   1234 C CA   . LEU A 1 87  ? -22.13546 -39.92440 4.08720   1.000 40.98394  ? 87  LEU A CA   1 
ATOM   1235 C C    . LEU A 1 87  ? -21.89359 -40.88459 5.24363   1.000 40.93969  ? 87  LEU A C    1 
ATOM   1236 O O    . LEU A 1 87  ? -21.00485 -40.66804 6.07214   1.000 40.35424  ? 87  LEU A O    1 
ATOM   1237 C CB   . LEU A 1 87  ? -21.10547 -40.19334 2.99181   1.000 43.23724  ? 87  LEU A CB   1 
ATOM   1238 C CG   . LEU A 1 87  ? -21.46044 -39.90612 1.53594   1.000 47.20206  ? 87  LEU A CG   1 
ATOM   1239 C CD1  . LEU A 1 87  ? -20.23747 -40.16000 0.65429   1.000 62.16974  ? 87  LEU A CD1  1 
ATOM   1240 C CD2  . LEU A 1 87  ? -22.63236 -40.74723 1.07881   1.000 47.80859  ? 87  LEU A CD2  1 
ATOM   1241 H H    . LEU A 1 87  ? -21.23462 -38.24493 4.55795   1.000 43.53293  ? 87  LEU A H    1 
ATOM   1242 H HA   . LEU A 1 87  ? -23.02216 -40.07777 3.72506   1.000 49.91680  ? 87  LEU A HA   1 
ATOM   1243 H HB2  . LEU A 1 87  ? -20.32440 -39.65419 3.19219   1.000 52.62076  ? 87  LEU A HB2  1 
ATOM   1244 H HB3  . LEU A 1 87  ? -20.87830 -41.13538 3.03502   1.000 52.62076  ? 87  LEU A HB3  1 
ATOM   1245 H HG   . LEU A 1 87  ? -21.72575 -38.97715 1.44923   1.000 57.37854  ? 87  LEU A HG   1 
ATOM   1246 H HD11 . LEU A 1 87  ? -20.48570 -40.03177 -0.27460  1.000 75.33976  ? 87  LEU A HD11 1 
ATOM   1247 H HD12 . LEU A 1 87  ? -19.53680 -39.53532 0.89870   1.000 75.33976  ? 87  LEU A HD12 1 
ATOM   1248 H HD13 . LEU A 1 87  ? -19.93205 -41.07024 0.79243   1.000 75.33976  ? 87  LEU A HD13 1 
ATOM   1249 H HD21 . LEU A 1 87  ? -22.80382 -40.56695 0.14126   1.000 58.10637  ? 87  LEU A HD21 1 
ATOM   1250 H HD22 . LEU A 1 87  ? -22.41502 -41.68463 1.20103   1.000 58.10637  ? 87  LEU A HD22 1 
ATOM   1251 H HD23 . LEU A 1 87  ? -23.41197 -40.51672 1.60793   1.000 58.10637  ? 87  LEU A HD23 1 
ATOM   1252 N N    . LYS A 1 88  ? -22.68035 -41.95438 5.28689   1.000 45.12954  ? 88  LYS A N    1 
ATOM   1253 C CA   . LYS A 1 88  ? -22.52050 -43.02251 6.27198   1.000 44.24055  ? 88  LYS A CA   1 
ATOM   1254 C C    . LYS A 1 88  ? -22.14082 -44.28843 5.50750   1.000 50.01300  ? 88  LYS A C    1 
ATOM   1255 O O    . LYS A 1 88  ? -22.99855 -44.93654 4.89833   1.000 51.64243  ? 88  LYS A O    1 
ATOM   1256 C CB   . LYS A 1 88  ? -23.79320 -43.19998 7.09728   1.000 47.36135  ? 88  LYS A CB   1 
ATOM   1257 C CG   . LYS A 1 88  ? -24.11749 -41.99549 7.98434   1.000 45.78621  ? 88  LYS A CG   1 
ATOM   1258 C CD   . LYS A 1 88  ? -25.19632 -42.30312 9.01905   1.000 49.69980  ? 88  LYS A CD   1 
ATOM   1259 C CE   . LYS A 1 88  ? -26.56380 -42.48590 8.38150   1.000 53.16176  ? 88  LYS A CE   1 
ATOM   1260 N NZ   . LYS A 1 88  ? -27.65757 -42.46392 9.39330   1.000 76.35252  ? 88  LYS A NZ   1 
ATOM   1261 H H    . LYS A 1 88  ? -23.33176 -42.08862 4.74168   1.000 54.89152  ? 88  LYS A H    1 
ATOM   1262 H HA   . LYS A 1 88  ? -21.80044 -42.80904 6.88586   1.000 53.82473  ? 88  LYS A HA   1 
ATOM   1263 H HB2  . LYS A 1 88  ? -24.54087 -43.33504 6.49425   1.000 57.56969  ? 88  LYS A HB2  1 
ATOM   1264 H HB3  . LYS A 1 88  ? -23.68745 -43.97341 7.67305   1.000 57.56969  ? 88  LYS A HB3  1 
ATOM   1265 H HG2  . LYS A 1 88  ? -23.31533 -41.72542 8.45814   1.000 55.67952  ? 88  LYS A HG2  1 
ATOM   1266 H HG3  . LYS A 1 88  ? -24.43467 -41.26754 7.42721   1.000 55.67952  ? 88  LYS A HG3  1 
ATOM   1267 H HD2  . LYS A 1 88  ? -24.96762 -43.12289 9.48443   1.000 60.37583  ? 88  LYS A HD2  1 
ATOM   1268 H HD3  . LYS A 1 88  ? -25.25246 -41.56823 9.64967   1.000 60.37583  ? 88  LYS A HD3  1 
ATOM   1269 H HE2  . LYS A 1 88  ? -26.72053 -41.76648 7.75001   1.000 64.53018  ? 88  LYS A HE2  1 
ATOM   1270 H HE3  . LYS A 1 88  ? -26.59122 -43.34078 7.92398   1.000 64.53018  ? 88  LYS A HE3  1 
ATOM   1271 H HZ1  . LYS A 1 88  ? -28.44537 -42.56691 8.99223   1.000 92.35909  ? 88  LYS A HZ1  1 
ATOM   1272 H HZ2  . LYS A 1 88  ? -27.54337 -43.12388 9.97939   1.000 92.35909  ? 88  LYS A HZ2  1 
ATOM   1273 H HZ3  . LYS A 1 88  ? -27.65425 -41.68749 9.82833   1.000 92.35909  ? 88  LYS A HZ3  1 
ATOM   1274 N N    . LEU A 1 89  ? -20.85136 -44.63065 5.53681   1.000 50.09872  ? 89  LEU A N    1 
ATOM   1275 C CA   . LEU A 1 89  ? -20.33949 -45.82463 4.87293   1.000 52.59698  ? 89  LEU A CA   1 
ATOM   1276 C C    . LEU A 1 89  ? -20.29981 -46.97659 5.87300   1.000 54.93791  ? 89  LEU A C    1 
ATOM   1277 O O    . LEU A 1 89  ? -19.50495 -46.95747 6.81819   1.000 52.62063  ? 89  LEU A O    1 
ATOM   1278 C CB   . LEU A 1 89  ? -18.94466 -45.57366 4.30482   1.000 51.38665  ? 89  LEU A CB   1 
ATOM   1279 C CG   . LEU A 1 89  ? -18.73502 -44.34595 3.42416   1.000 51.38575  ? 89  LEU A CG   1 
ATOM   1280 C CD1  . LEU A 1 89  ? -17.23712 -44.07833 3.29736   1.000 51.25330  ? 89  LEU A CD1  1 
ATOM   1281 C CD2  . LEU A 1 89  ? -19.36163 -44.52177 2.05964   1.000 56.35220  ? 89  LEU A CD2  1 
ATOM   1282 H H    . LEU A 1 89  ? -20.24424 -44.17690 5.94315   1.000 60.85454  ? 89  LEU A H    1 
ATOM   1283 H HA   . LEU A 1 89  ? -20.94048 -46.05758 4.14806   1.000 63.85245  ? 89  LEU A HA   1 
ATOM   1284 H HB2  . LEU A 1 89  ? -18.33407 -45.48589 5.05340   1.000 62.40004  ? 89  LEU A HB2  1 
ATOM   1285 H HB3  . LEU A 1 89  ? -18.70299 -46.34475 3.76823   1.000 62.40004  ? 89  LEU A HB3  1 
ATOM   1286 H HG   . LEU A 1 89  ? -19.16908 -43.58064 3.83258   1.000 62.39897  ? 89  LEU A HG   1 
ATOM   1287 H HD11 . LEU A 1 89  ? -17.10308 -43.27990 2.76309   1.000 62.24003  ? 89  LEU A HD11 1 
ATOM   1288 H HD12 . LEU A 1 89  ? -16.86311 -43.95025 4.18314   1.000 62.24003  ? 89  LEU A HD12 1 
ATOM   1289 H HD13 . LEU A 1 89  ? -16.81576 -44.83879 2.86718   1.000 62.24003  ? 89  LEU A HD13 1 
ATOM   1290 H HD21 . LEU A 1 89  ? -19.34946 -43.67065 1.59450   1.000 68.35871  ? 89  LEU A HD21 1 
ATOM   1291 H HD22 . LEU A 1 89  ? -18.85192 -45.17890 1.56036   1.000 68.35871  ? 89  LEU A HD22 1 
ATOM   1292 H HD23 . LEU A 1 89  ? -20.27620 -44.82593 2.16893   1.000 68.35871  ? 89  LEU A HD23 1 
ATOM   1293 N N    . LYS A 1 90  ? -21.14547 -47.98351 5.66038   1.000 57.46948  ? 90  LYS A N    1 
ATOM   1294 C CA   . LYS A 1 90  ? -21.06808 -49.20533 6.45086   1.000 60.39030  ? 90  LYS A CA   1 
ATOM   1295 C C    . LYS A 1 90  ? -19.84990 -50.01278 6.01543   1.000 61.94740  ? 90  LYS A C    1 
ATOM   1296 O O    . LYS A 1 90  ? -19.64642 -50.25371 4.82114   1.000 64.52338  ? 90  LYS A O    1 
ATOM   1297 C CB   . LYS A 1 90  ? -22.34102 -50.03463 6.28469   1.000 65.11777  ? 90  LYS A CB   1 
ATOM   1298 C CG   . LYS A 1 90  ? -22.35259 -51.33071 7.09172   1.000 68.74302  ? 90  LYS A CG   1 
ATOM   1299 C CD   . LYS A 1 90  ? -22.68339 -51.09208 8.56057   1.000 83.01452  ? 90  LYS A CD   1 
ATOM   1300 C CE   . LYS A 1 90  ? -24.17658 -51.24424 8.82655   1.000 91.29103  ? 90  LYS A CE   1 
ATOM   1301 N NZ   . LYS A 1 90  ? -24.51790 -51.03203 10.26216  1.000 95.99934  ? 90  LYS A NZ   1 
ATOM   1302 H H    . LYS A 1 90  ? -21.76865 -47.98256 5.06772   1.000 69.69944  ? 90  LYS A H    1 
ATOM   1303 H HA   . LYS A 1 90  ? -20.98166 -48.98253 7.39097   1.000 73.20442  ? 90  LYS A HA   1 
ATOM   1304 H HB2  . LYS A 1 90  ? -23.09837 -49.50155 6.57303   1.000 78.87739  ? 90  LYS A HB2  1 
ATOM   1305 H HB3  . LYS A 1 90  ? -22.43801 -50.26983 5.34865   1.000 78.87739  ? 90  LYS A HB3  1 
ATOM   1306 H HG2  . LYS A 1 90  ? -23.02252 -51.92855 6.72472   1.000 83.22769  ? 90  LYS A HG2  1 
ATOM   1307 H HG3  . LYS A 1 90  ? -21.47650 -51.74421 7.04294   1.000 83.22769  ? 90  LYS A HG3  1 
ATOM   1308 H HD2  . LYS A 1 90  ? -22.20873 -51.73845 9.10629   1.000 100.35349 ? 90  LYS A HD2  1 
ATOM   1309 H HD3  . LYS A 1 90  ? -22.41954 -50.19192 8.80757   1.000 100.35349 ? 90  LYS A HD3  1 
ATOM   1310 H HE2  . LYS A 1 90  ? -24.66199 -50.58943 8.30072   1.000 110.28530 ? 90  LYS A HE2  1 
ATOM   1311 H HE3  . LYS A 1 90  ? -24.45434 -52.14013 8.57931   1.000 110.28530 ? 90  LYS A HE3  1 
ATOM   1312 H HZ1  . LYS A 1 90  ? -25.40161 -51.00391 10.36399  1.000 115.93528 ? 90  LYS A HZ1  1 
ATOM   1313 H HZ2  . LYS A 1 90  ? -24.19148 -51.69787 10.75429  1.000 115.93528 ? 90  LYS A HZ2  1 
ATOM   1314 H HZ3  . LYS A 1 90  ? -24.16970 -50.26430 10.54756  1.000 115.93528 ? 90  LYS A HZ3  1 
ATOM   1315 N N    . VAL A 1 91  ? -19.03785 -50.43077 6.98337   1.000 61.20954  ? 91  VAL A N    1 
ATOM   1316 C CA   . VAL A 1 91  ? -17.83573 -51.20676 6.71608   1.000 61.49244  ? 91  VAL A CA   1 
ATOM   1317 C C    . VAL A 1 91  ? -17.94459 -52.54477 7.44221   1.000 62.24749  ? 91  VAL A C    1 
ATOM   1318 O O    . VAL A 1 91  ? -18.81234 -52.75085 8.29133   1.000 61.33955  ? 91  VAL A O    1 
ATOM   1319 C CB   . VAL A 1 91  ? -16.55159 -50.45874 7.12721   1.000 63.54304  ? 91  VAL A CB   1 
ATOM   1320 C CG1  . VAL A 1 91  ? -16.27696 -49.31571 6.15681   1.000 72.85551  ? 91  VAL A CG1  1 
ATOM   1321 C CG2  . VAL A 1 91  ? -16.66002 -49.93351 8.55427   1.000 59.70556  ? 91  VAL A CG2  1 
ATOM   1322 H H    . VAL A 1 91  ? -19.16709 -50.27274 7.81878   1.000 74.18751  ? 91  VAL A H    1 
ATOM   1323 H HA   . VAL A 1 91  ? -17.78434 -51.38714 5.76438   1.000 74.52699  ? 91  VAL A HA   1 
ATOM   1324 H HB   . VAL A 1 91  ? -15.80584 -51.07822 7.09549   1.000 76.98772  ? 91  VAL A HB   1 
ATOM   1325 H HG11 . VAL A 1 91  ? -15.49033 -48.83180 6.45335   1.000 88.16269  ? 91  VAL A HG11 1 
ATOM   1326 H HG12 . VAL A 1 91  ? -16.12558 -49.68241 5.27165   1.000 88.16269  ? 91  VAL A HG12 1 
ATOM   1327 H HG13 . VAL A 1 91  ? -17.04429 -48.72251 6.14231   1.000 88.16269  ? 91  VAL A HG13 1 
ATOM   1328 H HG21 . VAL A 1 91  ? -15.77801 -49.67329 8.86288   1.000 72.38275  ? 91  VAL A HG21 1 
ATOM   1329 H HG22 . VAL A 1 91  ? -17.25359 -49.16638 8.56419   1.000 72.38275  ? 91  VAL A HG22 1 
ATOM   1330 H HG23 . VAL A 1 91  ? -17.01586 -50.63444 9.12258   1.000 72.38275  ? 91  VAL A HG23 1 
ATOM   1331 N N    . ASP A 1 92  ? -17.04874 -53.46691 7.08121   1.000 64.04896  ? 92  ASP A N    1 
ATOM   1332 C CA   . ASP A 1 92  ? -17.08671 -54.79969 7.67145   1.000 63.98801  ? 92  ASP A CA   1 
ATOM   1333 C C    . ASP A 1 92  ? -16.38817 -54.84513 9.02422   1.000 65.08293  ? 92  ASP A C    1 
ATOM   1334 O O    . ASP A 1 92  ? -16.75693 -55.66009 9.87884   1.000 68.66419  ? 92  ASP A O    1 
ATOM   1335 C CB   . ASP A 1 92  ? -16.45821 -55.82081 6.71806   1.000 66.02865  ? 92  ASP A CB   1 
ATOM   1336 C CG   . ASP A 1 92  ? -15.02857 -55.47567 6.34068   1.000 66.47726  ? 92  ASP A CG   1 
ATOM   1337 O OD1  . ASP A 1 92  ? -14.51742 -54.43935 6.81170   1.000 66.24511  ? 92  ASP A OD1  1 
ATOM   1338 O OD2  . ASP A 1 92  ? -14.41569 -56.24460 5.56782   1.000 69.30229  ? 92  ASP A OD2  1 
ATOM   1339 H H    . ASP A 1 92  ? -16.42074 -53.34550 6.50635   1.000 77.59482  ? 92  ASP A H    1 
ATOM   1340 H HA   . ASP A 1 92  ? -18.01347 -55.05271 7.80556   1.000 77.52169  ? 92  ASP A HA   1 
ATOM   1341 H HB2  . ASP A 1 92  ? -16.45280 -56.69095 7.14671   1.000 79.97045  ? 92  ASP A HB2  1 
ATOM   1342 H HB3  . ASP A 1 92  ? -16.98276 -55.85581 5.90288   1.000 79.97045  ? 92  ASP A HB3  1 
ATOM   1343 N N    . THR A 1 93  ? -15.40480 -53.97436 9.24495   1.000 63.13245  ? 93  THR A N    1 
ATOM   1344 C CA   . THR A 1 93  ? -14.62102 -53.96870 10.47250  1.000 61.30895  ? 93  THR A CA   1 
ATOM   1345 C C    . THR A 1 93  ? -15.16297 -52.90077 11.41827  1.000 59.21507  ? 93  THR A C    1 
ATOM   1346 O O    . THR A 1 93  ? -15.25921 -51.72494 11.04481  1.000 56.78300  ? 93  THR A O    1 
ATOM   1347 C CB   . THR A 1 93  ? -13.14479 -53.70243 10.18169  1.000 62.43671  ? 93  THR A CB   1 
ATOM   1348 O OG1  . THR A 1 93  ? -12.69703 -54.54288 9.11536   1.000 65.60600  ? 93  THR A OG1  1 
ATOM   1349 C CG2  . THR A 1 93  ? -12.30154 -53.95878 11.42735  1.000 60.51678  ? 93  THR A CG2  1 
ATOM   1350 H H    . THR A 1 93  ? -15.17012 -53.36543 8.68484   1.000 76.49501  ? 93  THR A H    1 
ATOM   1351 H HA   . THR A 1 93  ? -14.70528 -54.83566 10.89934  1.000 74.30681  ? 93  THR A HA   1 
ATOM   1352 H HB   . THR A 1 93  ? -13.03016 -52.77526 9.92069   1.000 75.66012  ? 93  THR A HB   1 
ATOM   1353 H HG1  . THR A 1 93  ? -12.53956 -54.08058 8.43192   1.000 79.46327  ? 93  THR A HG1  1 
ATOM   1354 H HG21 . THR A 1 93  ? -11.52864 -54.49875 11.19942  1.000 73.35620  ? 93  THR A HG21 1 
ATOM   1355 H HG22 . THR A 1 93  ? -11.99809 -53.11690 11.80159  1.000 73.35620  ? 93  THR A HG22 1 
ATOM   1356 H HG23 . THR A 1 93  ? -12.82789 -54.42789 12.09353  1.000 73.35620  ? 93  THR A HG23 1 
ATOM   1357 N N    . ALA A 1 94  ? -15.49909 -53.30611 12.64007  1.000 57.16053  ? 94  ALA A N    1 
ATOM   1358 C CA   . ALA A 1 94  ? -15.76906 -52.35406 13.70762  1.000 54.40170  ? 94  ALA A CA   1 
ATOM   1359 C C    . ALA A 1 94  ? -14.44601 -51.81567 14.23754  1.000 53.69055  ? 94  ALA A C    1 
ATOM   1360 O O    . ALA A 1 94  ? -13.46737 -52.55732 14.36972  1.000 53.91951  ? 94  ALA A O    1 
ATOM   1361 C CB   . ALA A 1 94  ? -16.55871 -53.01245 14.83654  1.000 55.32632  ? 94  ALA A CB   1 
ATOM   1362 H H    . ALA A 1 94  ? -15.57726 -54.12969 12.87504  1.000 69.32870  ? 94  ALA A H    1 
ATOM   1363 H HA   . ALA A 1 94  ? -16.30474 -51.61837 13.37188  1.000 66.01811  ? 94  ALA A HA   1 
ATOM   1364 H HB1  . ALA A 1 94  ? -16.82277 -52.33225 15.47568  1.000 67.12765  ? 94  ALA A HB1  1 
ATOM   1365 H HB2  . ALA A 1 94  ? -17.34585 -53.43964 14.46396  1.000 67.12765  ? 94  ALA A HB2  1 
ATOM   1366 H HB3  . ALA A 1 94  ? -15.99745 -53.67398 15.27045  1.000 67.12765  ? 94  ALA A HB3  1 
ATOM   1367 N N    . ASN A 1 95  ? -14.40913 -50.52352 14.52107  1.000 51.50713  ? 95  ASN A N    1 
ATOM   1368 C CA   . ASN A 1 95  ? -13.18554 -49.91221 15.03702  1.000 50.56483  ? 95  ASN A CA   1 
ATOM   1369 C C    . ASN A 1 95  ? -12.92416 -50.44226 16.44109  1.000 48.93040  ? 95  ASN A C    1 
ATOM   1370 O O    . ASN A 1 95  ? -13.73682 -50.19809 17.34294  1.000 45.98683  ? 95  ASN A O    1 
ATOM   1371 C CB   . ASN A 1 95  ? -13.30731 -48.39267 15.05306  1.000 49.27321  ? 95  ASN A CB   1 
ATOM   1372 C CG   . ASN A 1 95  ? -12.00215 -47.70398 15.43480  1.000 47.69705  ? 95  ASN A CG   1 
ATOM   1373 O OD1  . ASN A 1 95  ? -11.04468 -48.34971 15.86466  1.000 48.42563  ? 95  ASN A OD1  1 
ATOM   1374 N ND2  . ASN A 1 95  ? -11.96485 -46.38465 15.28574  1.000 46.34738  ? 95  ASN A ND2  1 
ATOM   1375 H H    . ASN A 1 95  ? -15.06940 -49.98069 14.42625  1.000 62.54462  ? 95  ASN A H    1 
ATOM   1376 H HA   . ASN A 1 95  ? -12.43713 -50.13865 14.46300  1.000 61.41386  ? 95  ASN A HA   1 
ATOM   1377 H HB2  . ASN A 1 95  ? -13.56140 -48.08604 14.16858  1.000 59.86392  ? 95  ASN A HB2  1 
ATOM   1378 H HB3  . ASN A 1 95  ? -13.98296 -48.13598 15.69998  1.000 59.86392  ? 95  ASN A HB3  1 
ATOM   1379 H HD21 . ASN A 1 95  ? -11.25117 -45.94916 15.48723  1.000 56.35292  ? 95  ASN A HD21 1 
ATOM   1380 H HD22 . ASN A 1 95  ? -12.65438 -45.96593 14.98773  1.000 56.35292  ? 95  ASN A HD22 1 
ATOM   1381 N N    . PRO A 1 96  ? -11.83111 -51.17404 16.67707  1.000 48.82380  ? 96  PRO A N    1 
ATOM   1382 C CA   . PRO A 1 96  ? -11.54806 -51.62295 18.05120  1.000 48.98993  ? 96  PRO A CA   1 
ATOM   1383 C C    . PRO A 1 96  ? -11.27766 -50.47424 19.00279  1.000 47.76090  ? 96  PRO A C    1 
ATOM   1384 O O    . PRO A 1 96  ? -11.34109 -50.66939 20.22299  1.000 48.25516  ? 96  PRO A O    1 
ATOM   1385 C CB   . PRO A 1 96  ? -10.31600 -52.52329 17.88556  1.000 51.72392  ? 96  PRO A CB   1 
ATOM   1386 C CG   . PRO A 1 96  ? -9.64566  -52.01986 16.64896  1.000 55.49929  ? 96  PRO A CG   1 
ATOM   1387 C CD   . PRO A 1 96  ? -10.75519 -51.54861 15.73689  1.000 48.78993  ? 96  PRO A CD   1 
ATOM   1388 H HA   . PRO A 1 96  ? -12.28169 -52.15927 18.39038  1.000 59.52398  ? 96  PRO A HA   1 
ATOM   1389 H HB2  . PRO A 1 96  ? -9.73496  -52.43584 18.65734  1.000 62.80478  ? 96  PRO A HB2  1 
ATOM   1390 H HB3  . PRO A 1 96  ? -10.59192 -53.44732 17.78102  1.000 62.80478  ? 96  PRO A HB3  1 
ATOM   1391 H HG2  . PRO A 1 96  ? -9.05218  -51.28652 16.87455  1.000 67.33521  ? 96  PRO A HG2  1 
ATOM   1392 H HG3  . PRO A 1 96  ? -9.14264  -52.73827 16.23450  1.000 67.33521  ? 96  PRO A HG3  1 
ATOM   1393 H HD2  . PRO A 1 96  ? -10.47079 -50.78232 15.21457  1.000 59.28399  ? 96  PRO A HD2  1 
ATOM   1394 H HD3  . PRO A 1 96  ? -11.04461 -52.26275 15.14771  1.000 59.28399  ? 96  PRO A HD3  1 
ATOM   1395 N N    . LYS A 1 97  ? -10.99237 -49.28087 18.48389  1.000 49.70570  ? 97  LYS A N    1 
ATOM   1396 C CA   . LYS A 1 97  ? -10.69074 -48.11778 19.30273  1.000 47.17156  ? 97  LYS A CA   1 
ATOM   1397 C C    . LYS A 1 97  ? -11.89585 -47.20641 19.50311  1.000 46.09707  ? 97  LYS A C    1 
ATOM   1398 O O    . LYS A 1 97  ? -11.72792 -46.06955 19.95731  1.000 47.54675  ? 97  LYS A O    1 
ATOM   1399 C CB   . LYS A 1 97  ? -9.54301  -47.31895 18.67700  1.000 46.99698  ? 97  LYS A CB   1 
ATOM   1400 C CG   . LYS A 1 97  ? -8.31830  -48.14598 18.31248  1.000 50.73718  ? 97  LYS A CG   1 
ATOM   1401 C CD   . LYS A 1 97  ? -7.04539  -47.31361 18.42187  1.000 62.71521  ? 97  LYS A CD   1 
ATOM   1402 C CE   . LYS A 1 97  ? -5.87245  -47.96569 17.70588  1.000 65.64898  ? 97  LYS A CE   1 
ATOM   1403 N NZ   . LYS A 1 97  ? -5.71372  -47.45191 16.31528  1.000 74.96387  ? 97  LYS A NZ   1 
ATOM   1404 H H    . LYS A 1 97  ? -10.96777 -49.12033 17.63937  1.000 60.38290  ? 97  LYS A H    1 
ATOM   1405 H HA   . LYS A 1 97  ? -10.40547 -48.42871 20.17614  1.000 57.34194  ? 97  LYS A HA   1 
ATOM   1406 H HB2  . LYS A 1 97  ? -9.86603  -46.90085 17.86352  1.000 57.13245  ? 97  LYS A HB2  1 
ATOM   1407 H HB3  . LYS A 1 97  ? -9.25957  -46.63991 19.30905  1.000 57.13245  ? 97  LYS A HB3  1 
ATOM   1408 H HG2  . LYS A 1 97  ? -8.24523  -48.89990 18.91843  1.000 61.62068  ? 97  LYS A HG2  1 
ATOM   1409 H HG3  . LYS A 1 97  ? -8.40138  -48.46141 17.39897  1.000 61.62068  ? 97  LYS A HG3  1 
ATOM   1410 H HD2  . LYS A 1 97  ? -7.19791  -46.44325 18.02174  1.000 75.99432  ? 97  LYS A HD2  1 
ATOM   1411 H HD3  . LYS A 1 97  ? -6.80999  -47.21202 19.35737  1.000 75.99432  ? 97  LYS A HD3  1 
ATOM   1412 H HE2  . LYS A 1 97  ? -5.05555  -47.77733 18.19384  1.000 79.51484  ? 97  LYS A HE2  1 
ATOM   1413 H HE3  . LYS A 1 97  ? -6.01838  -48.92357 17.66044  1.000 79.51484  ? 97  LYS A HE3  1 
ATOM   1414 H HZ1  . LYS A 1 97  ? -5.03069  -47.85972 15.91621  1.000 90.69272  ? 97  LYS A HZ1  1 
ATOM   1415 H HZ2  . LYS A 1 97  ? -6.45512  -47.60559 15.84751  1.000 90.69272  ? 97  LYS A HZ2  1 
ATOM   1416 H HZ3  . LYS A 1 97  ? -5.55813  -46.57575 16.33039  1.000 90.69272  ? 97  LYS A HZ3  1 
ATOM   1417 N N    . THR A 1 98  ? -13.09652 -47.67082 19.18213  1.000 45.04081  ? 98  THR A N    1 
ATOM   1418 C CA   . THR A 1 98  ? -14.27836 -46.83166 19.31864  1.000 44.01485  ? 98  THR A CA   1 
ATOM   1419 C C    . THR A 1 98  ? -14.47245 -46.43771 20.77979  1.000 44.08407  ? 98  THR A C    1 
ATOM   1420 O O    . THR A 1 98  ? -14.68372 -47.32009 21.62809  1.000 41.97520  ? 98  THR A O    1 
ATOM   1421 C CB   . THR A 1 98  ? -15.52779 -47.55165 18.81874  1.000 45.27548  ? 98  THR A CB   1 
ATOM   1422 O OG1  . THR A 1 98  ? -15.32528 -47.99869 17.47715  1.000 46.71922  ? 98  THR A OG1  1 
ATOM   1423 C CG2  . THR A 1 98  ? -16.72870 -46.61517 18.85296  1.000 44.02650  ? 98  THR A CG2  1 
ATOM   1424 H H    . THR A 1 98  ? -13.25239 -48.46270 18.88510  1.000 54.78504  ? 98  THR A H    1 
ATOM   1425 H HA   . THR A 1 98  ? -14.15276 -46.03429 18.78074  1.000 53.55388  ? 98  THR A HA   1 
ATOM   1426 H HB   . THR A 1 98  ? -15.70885 -48.31423 19.39023  1.000 55.06664  ? 98  THR A HB   1 
ATOM   1427 H HG1  . THR A 1 98  ? -14.74557 -48.60637 17.46123  1.000 56.79914  ? 98  THR A HG1  1 
ATOM   1428 H HG21 . THR A 1 98  ? -17.47920 -47.02109 18.39157  1.000 53.56787  ? 98  THR A HG21 1 
ATOM   1429 H HG22 . THR A 1 98  ? -16.98354 -46.43589 19.77156  1.000 53.56787  ? 98  THR A HG22 1 
ATOM   1430 H HG23 . THR A 1 98  ? -16.50802 -45.77665 18.41812  1.000 53.56787  ? 98  THR A HG23 1 
ATOM   1431 N N    . PRO A 1 99  ? -14.40692 -45.15592 21.12154  1.000 42.09530  ? 99  PRO A N    1 
ATOM   1432 C CA   . PRO A 1 99  ? -14.68297 -44.73878 22.49913  1.000 39.58528  ? 99  PRO A CA   1 
ATOM   1433 C C    . PRO A 1 99  ? -16.18183 -44.71102 22.76872  1.000 39.93696  ? 99  PRO A C    1 
ATOM   1434 O O    . PRO A 1 99  ? -17.00991 -44.76297 21.85881  1.000 42.47708  ? 99  PRO A O    1 
ATOM   1435 C CB   . PRO A 1 99  ? -14.08508 -43.32941 22.56795  1.000 39.07416  ? 99  PRO A CB   1 
ATOM   1436 C CG   . PRO A 1 99  ? -14.23908 -42.80788 21.16281  1.000 40.64047  ? 99  PRO A CG   1 
ATOM   1437 C CD   . PRO A 1 99  ? -14.03974 -44.01337 20.25817  1.000 41.31841  ? 99  PRO A CD   1 
ATOM   1438 H HA   . PRO A 1 99  ? -14.23820 -45.31592 23.13944  1.000 48.23840  ? 99  PRO A HA   1 
ATOM   1439 H HB2  . PRO A 1 99  ? -14.57946 -42.78585 23.20122  1.000 47.62506  ? 99  PRO A HB2  1 
ATOM   1440 H HB3  . PRO A 1 99  ? -13.15124 -43.37344 22.82659  1.000 47.62506  ? 99  PRO A HB3  1 
ATOM   1441 H HG2  . PRO A 1 99  ? -15.12602 -42.43264 21.04690  1.000 49.50463  ? 99  PRO A HG2  1 
ATOM   1442 H HG3  . PRO A 1 99  ? -13.56693 -42.13069 20.98810  1.000 49.50463  ? 99  PRO A HG3  1 
ATOM   1443 H HD2  . PRO A 1 99  ? -14.62334 -43.96422 19.48494  1.000 50.31816  ? 99  PRO A HD2  1 
ATOM   1444 H HD3  . PRO A 1 99  ? -13.11525 -44.08058 19.97232  1.000 50.31816  ? 99  PRO A HD3  1 
ATOM   1445 N N    . LYS A 1 100 ? -16.52418 -44.64348 24.05153  1.000 39.27136  ? 100 LYS A N    1 
ATOM   1446 C CA   . LYS A 1 100 ? -17.86583 -44.21388 24.41977  1.000 41.05204  ? 100 LYS A CA   1 
ATOM   1447 C C    . LYS A 1 100 ? -18.08716 -42.83846 23.80362  1.000 40.18446  ? 100 LYS A C    1 
ATOM   1448 O O    . LYS A 1 100 ? -17.31023 -41.91027 24.05536  1.000 40.20038  ? 100 LYS A O    1 
ATOM   1449 C CB   . LYS A 1 100 ? -18.02584 -44.16217 25.93469  1.000 42.13214  ? 100 LYS A CB   1 
ATOM   1450 H H    . LYS A 1 100 ? -16.00881 -44.83689 24.71228  1.000 47.86169  ? 100 LYS A H    1 
ATOM   1451 H HA   . LYS A 1 100 ? -18.52919 -44.84298 24.09559  1.000 49.99852  ? 100 LYS A HA   1 
ATOM   1452 N N    . TYR A 1 101 ? -19.11101 -42.70734 22.96691  1.000 37.24426  ? 101 TYR A N    1 
ATOM   1453 C CA   . TYR A 1 101 ? -19.30683 -41.46543 22.23853  1.000 36.81988  ? 101 TYR A CA   1 
ATOM   1454 C C    . TYR A 1 101 ? -20.78844 -41.15180 22.12092  1.000 37.71310  ? 101 TYR A C    1 
ATOM   1455 O O    . TYR A 1 101 ? -21.65089 -42.02697 22.20123  1.000 38.57871  ? 101 TYR A O    1 
ATOM   1456 C CB   . TYR A 1 101 ? -18.67000 -41.53369 20.83996  1.000 36.88514  ? 101 TYR A CB   1 
ATOM   1457 C CG   . TYR A 1 101 ? -19.41422 -42.42387 19.87127  1.000 38.66406  ? 101 TYR A CG   1 
ATOM   1458 C CD1  . TYR A 1 101 ? -20.47072 -41.92743 19.11653  1.000 37.32733  ? 101 TYR A CD1  1 
ATOM   1459 C CD2  . TYR A 1 101 ? -19.06278 -43.75683 19.70811  1.000 40.43333  ? 101 TYR A CD2  1 
ATOM   1460 C CE1  . TYR A 1 101 ? -21.15791 -42.73085 18.23391  1.000 38.33854  ? 101 TYR A CE1  1 
ATOM   1461 C CE2  . TYR A 1 101 ? -19.74577 -44.56987 18.82053  1.000 41.88668  ? 101 TYR A CE2  1 
ATOM   1462 C CZ   . TYR A 1 101 ? -20.79123 -44.05027 18.08784  1.000 41.38403  ? 101 TYR A CZ   1 
ATOM   1463 O OH   . TYR A 1 101 ? -21.48169 -44.84561 17.20430  1.000 46.39216  ? 101 TYR A OH   1 
ATOM   1464 H H    . TYR A 1 101 ? -19.69658 -43.31683 22.80808  1.000 45.42919  ? 101 TYR A H    1 
ATOM   1465 H HA   . TYR A 1 101 ? -18.89609 -40.74188 22.73720  1.000 44.91993  ? 101 TYR A HA   1 
ATOM   1466 H HB2  . TYR A 1 101 ? -18.64887 -40.63996 20.46353  1.000 44.99824  ? 101 TYR A HB2  1 
ATOM   1467 H HB3  . TYR A 1 101 ? -17.76763 -41.87917 20.92528  1.000 44.99824  ? 101 TYR A HB3  1 
ATOM   1468 H HD1  . TYR A 1 101 ? -20.71823 -41.03579 19.20936  1.000 45.52886  ? 101 TYR A HD1  1 
ATOM   1469 H HD2  . TYR A 1 101 ? -18.35802 -44.10868 20.20250  1.000 49.25607  ? 101 TYR A HD2  1 
ATOM   1470 H HE1  . TYR A 1 101 ? -21.86534 -42.38446 17.73949  1.000 46.74232  ? 101 TYR A HE1  1 
ATOM   1471 H HE2  . TYR A 1 101 ? -19.50085 -45.46128 18.71908  1.000 51.00008  ? 101 TYR A HE2  1 
ATOM   1472 H HH   . TYR A 1 101 ? -21.14758 -45.61617 17.18982  1.000 56.40666  ? 101 TYR A HH   1 
ATOM   1473 N N    . LYS A 1 102 ? -21.05739 -39.86142 21.94093  1.000 38.59843  ? 102 LYS A N    1 
ATOM   1474 C CA   . LYS A 1 102 ? -22.37260 -39.34201 21.61322  1.000 38.17648  ? 102 LYS A CA   1 
ATOM   1475 C C    . LYS A 1 102 ? -22.22340 -38.37835 20.44336  1.000 32.61594  ? 102 LYS A C    1 
ATOM   1476 O O    . LYS A 1 102 ? -21.14232 -37.83638 20.19521  1.000 31.94175  ? 102 LYS A O    1 
ATOM   1477 C CB   . LYS A 1 102 ? -23.01691 -38.60866 22.79903  1.000 41.15272  ? 102 LYS A CB   1 
ATOM   1478 C CG   . LYS A 1 102 ? -23.76142 -39.50198 23.77809  1.000 55.89835  ? 102 LYS A CG   1 
ATOM   1479 C CD   . LYS A 1 102 ? -24.37972 -38.69013 24.91232  1.000 73.12858  ? 102 LYS A CD   1 
ATOM   1480 C CE   . LYS A 1 102 ? -25.44748 -39.49201 25.64512  1.000 85.33050  ? 102 LYS A CE   1 
ATOM   1481 N NZ   . LYS A 1 102 ? -26.00836 -38.75623 26.81259  1.000 79.30850  ? 102 LYS A NZ   1 
ATOM   1482 H H    . LYS A 1 102 ? -20.46422 -39.24227 22.00731  1.000 47.05419  ? 102 LYS A H    1 
ATOM   1483 H HA   . LYS A 1 102 ? -22.95953 -40.07282 21.36357  1.000 46.54785  ? 102 LYS A HA   1 
ATOM   1484 H HB2  . LYS A 1 102 ? -22.31853 -38.15276 23.29432  1.000 50.11934  ? 102 LYS A HB2  1 
ATOM   1485 H HB3  . LYS A 1 102 ? -23.65290 -37.96354 22.45227  1.000 50.11934  ? 102 LYS A HB3  1 
ATOM   1486 H HG2  . LYS A 1 102 ? -24.47371 -39.96689 23.31182  1.000 67.81409  ? 102 LYS A HG2  1 
ATOM   1487 H HG3  . LYS A 1 102 ? -23.14330 -40.14282 24.16298  1.000 67.81409  ? 102 LYS A HG3  1 
ATOM   1488 H HD2  . LYS A 1 102 ? -23.68906 -38.44694 25.54851  1.000 88.49037  ? 102 LYS A HD2  1 
ATOM   1489 H HD3  . LYS A 1 102 ? -24.79246 -37.89100 24.54909  1.000 88.49037  ? 102 LYS A HD3  1 
ATOM   1490 H HE2  . LYS A 1 102 ? -26.17491 -39.68588 25.03344  1.000 103.13266 ? 102 LYS A HE2  1 
ATOM   1491 H HE3  . LYS A 1 102 ? -25.05732 -40.31882 25.96927  1.000 103.13266 ? 102 LYS A HE3  1 
ATOM   1492 H HZ1  . LYS A 1 102 ? -26.88413 -38.90295 26.87271  1.000 95.90627  ? 102 LYS A HZ1  1 
ATOM   1493 H HZ2  . LYS A 1 102 ? -25.61710 -39.03214 27.56285  1.000 95.90627  ? 102 LYS A HZ2  1 
ATOM   1494 H HZ3  . LYS A 1 102 ? -25.86771 -37.88253 26.71791  1.000 95.90627  ? 102 LYS A HZ3  1 
ATOM   1495 N N    . PHE A 1 103 ? -23.31817 -38.17621 19.72001  1.000 30.36925  ? 103 PHE A N    1 
ATOM   1496 C CA   . PHE A 1 103 ? -23.44930 -37.06163 18.79183  1.000 29.51569  ? 103 PHE A CA   1 
ATOM   1497 C C    . PHE A 1 103 ? -24.29547 -35.98860 19.46668  1.000 30.84216  ? 103 PHE A C    1 
ATOM   1498 O O    . PHE A 1 103 ? -25.36360 -36.29126 20.01362  1.000 32.33062  ? 103 PHE A O    1 
ATOM   1499 C CB   . PHE A 1 103 ? -24.10374 -37.48880 17.47956  1.000 27.99830  ? 103 PHE A CB   1 
ATOM   1500 C CG   . PHE A 1 103 ? -23.24690 -38.38242 16.62668  1.000 29.02251  ? 103 PHE A CG   1 
ATOM   1501 C CD1  . PHE A 1 103 ? -21.90171 -38.56022 16.90231  1.000 29.18382  ? 103 PHE A CD1  1 
ATOM   1502 C CD2  . PHE A 1 103 ? -23.79388 -39.04018 15.53832  1.000 30.06377  ? 103 PHE A CD2  1 
ATOM   1503 C CE1  . PHE A 1 103 ? -21.11863 -39.38220 16.10832  1.000 29.88589  ? 103 PHE A CE1  1 
ATOM   1504 C CE2  . PHE A 1 103 ? -23.01998 -39.86116 14.74326  1.000 31.48777  ? 103 PHE A CE2  1 
ATOM   1505 C CZ   . PHE A 1 103 ? -21.68044 -40.03233 15.02760  1.000 32.91431  ? 103 PHE A CZ   1 
ATOM   1506 H H    . PHE A 1 103 ? -24.01285 -38.68226 19.75058  1.000 37.17917  ? 103 PHE A H    1 
ATOM   1507 H HA   . PHE A 1 103 ? -22.57190 -36.70902 18.57562  1.000 36.15490  ? 103 PHE A HA   1 
ATOM   1508 H HB2  . PHE A 1 103 ? -24.92060 -37.97084 17.68272  1.000 34.33402  ? 103 PHE A HB2  1 
ATOM   1509 H HB3  . PHE A 1 103 ? -24.30739 -36.69447 16.96143  1.000 34.33402  ? 103 PHE A HB3  1 
ATOM   1510 H HD1  . PHE A 1 103 ? -21.51954 -38.12291 17.62867  1.000 35.75665  ? 103 PHE A HD1  1 
ATOM   1511 H HD2  . PHE A 1 103 ? -24.69547 -38.92731 15.34007  1.000 36.81260  ? 103 PHE A HD2  1 
ATOM   1512 H HE1  . PHE A 1 103 ? -20.21633 -39.49583 16.30288  1.000 36.59914  ? 103 PHE A HE1  1 
ATOM   1513 H HE2  . PHE A 1 103 ? -23.40098 -40.29869 14.01641  1.000 38.52139  ? 103 PHE A HE2  1 
ATOM   1514 H HZ   . PHE A 1 103 ? -21.15730 -40.58441 14.49242  1.000 40.23324  ? 103 PHE A HZ   1 
ATOM   1515 N N    . VAL A 1 104 ? -23.82584 -34.74203 19.42893  1.000 28.79161  ? 104 VAL A N    1 
ATOM   1516 C CA   . VAL A 1 104 ? -24.56360 -33.62959 20.01369  1.000 28.84838  ? 104 VAL A CA   1 
ATOM   1517 C C    . VAL A 1 104 ? -24.51071 -32.42981 19.07763  1.000 30.09082  ? 104 VAL A C    1 
ATOM   1518 O O    . VAL A 1 104 ? -23.52332 -32.20531 18.37341  1.000 29.96429  ? 104 VAL A O    1 
ATOM   1519 C CB   . VAL A 1 104 ? -24.00944 -33.23208 21.39850  1.000 30.71715  ? 104 VAL A CB   1 
ATOM   1520 C CG1  . VAL A 1 104 ? -23.91395 -34.44736 22.30230  1.000 32.65954  ? 104 VAL A CG1  1 
ATOM   1521 C CG2  . VAL A 1 104 ? -22.65401 -32.55992 21.24906  1.000 30.80025  ? 104 VAL A CG2  1 
ATOM   1522 H H    . VAL A 1 104 ? -23.07839 -34.51727 19.06782  1.000 35.28600  ? 104 VAL A H    1 
ATOM   1523 H HA   . VAL A 1 104 ? -25.49007 -33.90075 20.10869  1.000 35.35412  ? 104 VAL A HA   1 
ATOM   1524 H HB   . VAL A 1 104 ? -24.61634 -32.59965 21.81395  1.000 37.59665  ? 104 VAL A HB   1 
ATOM   1525 H HG11 . VAL A 1 104 ? -23.72447 -34.15385 23.20720  1.000 39.92752  ? 104 VAL A HG11 1 
ATOM   1526 H HG12 . VAL A 1 104 ? -24.75785 -34.92506 22.27938  1.000 39.92752  ? 104 VAL A HG12 1 
ATOM   1527 H HG13 . VAL A 1 104 ? -23.19990 -35.02189 21.98456  1.000 39.92752  ? 104 VAL A HG13 1 
ATOM   1528 H HG21 . VAL A 1 104 ? -22.18943 -32.59331 22.09991  1.000 37.69637  ? 104 VAL A HG21 1 
ATOM   1529 H HG22 . VAL A 1 104 ? -22.14103 -33.03029 20.57341  1.000 37.69637  ? 104 VAL A HG22 1 
ATOM   1530 H HG23 . VAL A 1 104 ? -22.78691 -31.63729 20.98074  1.000 37.69637  ? 104 VAL A HG23 1 
ATOM   1531 N N    . ARG A 1 105 ? -25.58609 -31.65146 19.08223  1.000 30.19626  ? 105 ARG A N    1 
ATOM   1532 C CA   . ARG A 1 105 ? -25.63355 -30.37641 18.37706  1.000 30.13915  ? 105 ARG A CA   1 
ATOM   1533 C C    . ARG A 1 105 ? -25.46419 -29.27363 19.41716  1.000 32.13315  ? 105 ARG A C    1 
ATOM   1534 O O    . ARG A 1 105 ? -26.36307 -29.03414 20.23340  1.000 32.22371  ? 105 ARG A O    1 
ATOM   1535 C CB   . ARG A 1 105 ? -26.93807 -30.22044 17.60634  1.000 29.10599  ? 105 ARG A CB   1 
ATOM   1536 C CG   . ARG A 1 105 ? -26.92016 -29.04841 16.64576  1.000 27.86347  ? 105 ARG A CG   1 
ATOM   1537 C CD   . ARG A 1 105 ? -28.19003 -28.97284 15.82516  1.000 35.09376  ? 105 ARG A CD   1 
ATOM   1538 N NE   . ARG A 1 105 ? -28.23124 -27.75877 15.01879  1.000 33.09590  ? 105 ARG A NE   1 
ATOM   1539 C CZ   . ARG A 1 105 ? -27.60880 -27.60883 13.85795  1.000 30.87480  ? 105 ARG A CZ   1 
ATOM   1540 N NH1  . ARG A 1 105 ? -26.88070 -28.58018 13.33559  1.000 30.92144  ? 105 ARG A NH1  1 
ATOM   1541 N NH2  . ARG A 1 105 ? -27.71969 -26.45509 13.20707  1.000 26.76646  ? 105 ARG A NH2  1 
ATOM   1542 H H    . ARG A 1 105 ? -26.31542 -31.84434 19.49512  1.000 36.97158  ? 105 ARG A H    1 
ATOM   1543 H HA   . ARG A 1 105 ? -24.90762 -30.32432 17.73580  1.000 36.90304  ? 105 ARG A HA   1 
ATOM   1544 H HB2  . ARG A 1 105 ? -27.09830 -31.02703 17.09191  1.000 35.66325  ? 105 ARG A HB2  1 
ATOM   1545 H HB3  . ARG A 1 105 ? -27.66159 -30.07994 18.23696  1.000 35.66325  ? 105 ARG A HB3  1 
ATOM   1546 H HG2  . ARG A 1 105 ? -26.83465 -28.22358 17.14899  1.000 34.17223  ? 105 ARG A HG2  1 
ATOM   1547 H HG3  . ARG A 1 105 ? -26.17102 -29.14494 16.03718  1.000 34.17223  ? 105 ARG A HG3  1 
ATOM   1548 H HD2  . ARG A 1 105 ? -28.23358 -29.73695 15.22922  1.000 42.84858  ? 105 ARG A HD2  1 
ATOM   1549 H HD3  . ARG A 1 105 ? -28.95692 -28.97121 16.41911  1.000 42.84858  ? 105 ARG A HD3  1 
ATOM   1550 H HE   . ARG A 1 105 ? -28.69031 -27.09518 15.31629  1.000 40.45115  ? 105 ARG A HE   1 
ATOM   1551 H HH11 . ARG A 1 105 ? -26.80279 -29.32968 13.75004  1.000 37.84179  ? 105 ARG A HH11 1 
ATOM   1552 H HH12 . ARG A 1 105 ? -26.48481 -28.46277 12.58121  1.000 37.84179  ? 105 ARG A HH12 1 
ATOM   1553 H HH21 . ARG A 1 105 ? -28.19084 -25.81722 13.53982  1.000 32.85582  ? 105 ARG A HH21 1 
ATOM   1554 H HH22 . ARG A 1 105 ? -27.32027 -26.34655 12.45322  1.000 32.85582  ? 105 ARG A HH22 1 
ATOM   1555 N N    . ILE A 1 106 ? -24.30164 -28.62007 19.40042  1.000 31.31818  ? 106 ILE A N    1 
ATOM   1556 C CA   . ILE A 1 106 ? -23.99613 -27.56963 20.36450  1.000 32.51755  ? 106 ILE A CA   1 
ATOM   1557 C C    . ILE A 1 106 ? -24.76222 -26.30549 19.99899  1.000 32.84212  ? 106 ILE A C    1 
ATOM   1558 O O    . ILE A 1 106 ? -25.27159 -26.17207 18.87901  1.000 31.86786  ? 106 ILE A O    1 
ATOM   1559 C CB   . ILE A 1 106 ? -22.48435 -27.26968 20.43466  1.000 31.84825  ? 106 ILE A CB   1 
ATOM   1560 C CG1  . ILE A 1 106 ? -21.96024 -26.82783 19.06749  1.000 31.19376  ? 106 ILE A CG1  1 
ATOM   1561 C CG2  . ILE A 1 106 ? -21.72203 -28.47624 20.94908  1.000 36.17217  ? 106 ILE A CG2  1 
ATOM   1562 C CD1  . ILE A 1 106 ? -20.60373 -26.14732 19.13039  1.000 33.15303  ? 106 ILE A CD1  1 
ATOM   1563 H H    . ILE A 1 106 ? -23.67074 -28.76971 18.83547  1.000 38.31788  ? 106 ILE A H    1 
ATOM   1564 H HA   . ILE A 1 106 ? -24.28757 -27.87494 21.23785  1.000 39.75713  ? 106 ILE A HA   1 
ATOM   1565 H HB   . ILE A 1 106 ? -22.34731 -26.53991 21.05879  1.000 38.95397  ? 106 ILE A HB   1 
ATOM   1566 H HG12 . ILE A 1 106 ? -21.87511 -27.60829 18.49781  1.000 38.16858  ? 106 ILE A HG12 1 
ATOM   1567 H HG13 . ILE A 1 106 ? -22.58975 -26.20048 18.67884  1.000 38.16858  ? 106 ILE A HG13 1 
ATOM   1568 H HG21 . ILE A 1 106 ? -20.77040 -28.30562 20.87039  1.000 44.14267  ? 106 ILE A HG21 1 
ATOM   1569 H HG22 . ILE A 1 106 ? -21.95572 -28.62461 21.87874  1.000 44.14267  ? 106 ILE A HG22 1 
ATOM   1570 H HG23 . ILE A 1 106 ? -21.96390 -29.25199 20.41935  1.000 44.14267  ? 106 ILE A HG23 1 
ATOM   1571 H HD11 . ILE A 1 106 ? -20.30774 -25.94905 18.22818  1.000 40.51970  ? 106 ILE A HD11 1 
ATOM   1572 H HD12 . ILE A 1 106 ? -20.68583 -25.32583 19.63962  1.000 40.51970  ? 106 ILE A HD12 1 
ATOM   1573 H HD13 . ILE A 1 106 ? -19.97151 -26.74263 19.56260  1.000 40.51970  ? 106 ILE A HD13 1 
ATOM   1574 N N    . GLN A 1 107 ? -24.82529 -25.37123 20.92813  1.000 34.92823  ? 107 GLN A N    1 
ATOM   1575 C CA   . GLN A 1 107 ? -25.42954 -24.06864 20.72761  1.000 33.97478  ? 107 GLN A CA   1 
ATOM   1576 C C    . GLN A 1 107 ? -24.35375 -23.02212 20.49316  1.000 31.87475  ? 107 GLN A C    1 
ATOM   1577 O O    . GLN A 1 107 ? -23.20562 -23.19102 20.91629  1.000 32.82526  ? 107 GLN A O    1 
ATOM   1578 C CB   . GLN A 1 107 ? -26.26542 -23.68223 21.94915  1.000 38.88873  ? 107 GLN A CB   1 
ATOM   1579 C CG   . GLN A 1 107 ? -27.47895 -24.56759 22.17448  1.000 41.91703  ? 107 GLN A CG   1 
ATOM   1580 C CD   . GLN A 1 107 ? -28.52501 -24.40575 21.08841  1.000 46.09362  ? 107 GLN A CD   1 
ATOM   1581 O OE1  . GLN A 1 107 ? -28.76732 -23.30104 20.60282  1.000 47.22335  ? 107 GLN A OE1  1 
ATOM   1582 N NE2  . GLN A 1 107 ? -29.14509 -25.51164 20.69607  1.000 60.47642  ? 107 GLN A NE2  1 
ATOM   1583 H H    . GLN A 1 107 ? -24.50978 -25.47251 21.72173  1.000 42.64995  ? 107 GLN A H    1 
ATOM   1584 H HA   . GLN A 1 107 ? -26.01516 -24.09053 19.95465  1.000 41.50581  ? 107 GLN A HA   1 
ATOM   1585 H HB2  . GLN A 1 107 ? -25.70627 -23.74165 22.73954  1.000 47.40255  ? 107 GLN A HB2  1 
ATOM   1586 H HB3  . GLN A 1 107 ? -26.58152 -22.77243 21.83402  1.000 47.40255  ? 107 GLN A HB3  1 
ATOM   1587 H HG2  . GLN A 1 107 ? -27.19688 -25.49561 22.18486  1.000 51.03650  ? 107 GLN A HG2  1 
ATOM   1588 H HG3  . GLN A 1 107 ? -27.88761 -24.33554 23.02303  1.000 51.03650  ? 107 GLN A HG3  1 
ATOM   1589 H HE21 . GLN A 1 107 ? -28.94526 -26.26711 21.05514  1.000 73.30777  ? 107 GLN A HE21 1 
ATOM   1590 H HE22 . GLN A 1 107 ? -29.74672 -25.47277 20.08278  1.000 73.30777  ? 107 GLN A HE22 1 
ATOM   1591 N N    . PRO A 1 108 ? -24.68262 -21.92477 19.81272  1.000 32.51840  ? 108 PRO A N    1 
ATOM   1592 C CA   . PRO A 1 108 ? -23.70077 -20.84561 19.65236  1.000 30.65046  ? 108 PRO A CA   1 
ATOM   1593 C C    . PRO A 1 108 ? -23.17247 -20.40165 21.00849  1.000 30.79961  ? 108 PRO A C    1 
ATOM   1594 O O    . PRO A 1 108 ? -23.89458 -20.39976 22.00842  1.000 34.70390  ? 108 PRO A O    1 
ATOM   1595 C CB   . PRO A 1 108 ? -24.49343 -19.73785 18.95199  1.000 32.39819  ? 108 PRO A CB   1 
ATOM   1596 C CG   . PRO A 1 108 ? -25.94160 -20.08186 19.16751  1.000 32.24340  ? 108 PRO A CG   1 
ATOM   1597 C CD   . PRO A 1 108 ? -25.99144 -21.58216 19.22136  1.000 33.66214  ? 108 PRO A CD   1 
ATOM   1598 H HA   . PRO A 1 108 ? -22.96582 -21.11857 19.08117  1.000 37.51663  ? 108 PRO A HA   1 
ATOM   1599 H HB2  . PRO A 1 108 ? -24.27951 -18.87952 19.35000  1.000 39.61390  ? 108 PRO A HB2  1 
ATOM   1600 H HB3  . PRO A 1 108 ? -24.27794 -19.72795 18.00628  1.000 39.61390  ? 108 PRO A HB3  1 
ATOM   1601 H HG2  . PRO A 1 108 ? -26.25073 -19.69603 20.00205  1.000 39.42815  ? 108 PRO A HG2  1 
ATOM   1602 H HG3  . PRO A 1 108 ? -26.47314 -19.74509 18.42930  1.000 39.42815  ? 108 PRO A HG3  1 
ATOM   1603 H HD2  . PRO A 1 108 ? -26.71904 -21.88631 19.78614  1.000 41.13063  ? 108 PRO A HD2  1 
ATOM   1604 H HD3  . PRO A 1 108 ? -26.08139 -21.95968 18.33237  1.000 41.13063  ? 108 PRO A HD3  1 
ATOM   1605 N N    . GLY A 1 109 ? -21.89261 -20.04555 21.04397  1.000 29.15745  ? 109 GLY A N    1 
ATOM   1606 C CA   . GLY A 1 109 ? -21.23573 -19.66181 22.26610  1.000 30.28805  ? 109 GLY A CA   1 
ATOM   1607 C C    . GLY A 1 109 ? -20.54795 -20.79089 23.00130  1.000 31.01457  ? 109 GLY A C    1 
ATOM   1608 O O    . GLY A 1 109 ? -19.67357 -20.52432 23.83417  1.000 34.27336  ? 109 GLY A O    1 
ATOM   1609 H H    . GLY A 1 109 ? -21.38091 -20.02087 20.35320  1.000 35.72501  ? 109 GLY A H    1 
ATOM   1610 H HA2  . GLY A 1 109 ? -20.56564 -18.99114 22.06101  1.000 37.08172  ? 109 GLY A HA2  1 
ATOM   1611 H HA3  . GLY A 1 109 ? -21.89460 -19.27709 22.86509  1.000 37.08172  ? 109 GLY A HA3  1 
ATOM   1612 N N    . GLN A 1 110 ? -20.91534 -22.03922 22.72385  1.000 30.15451  ? 110 GLN A N    1 
ATOM   1613 C CA   . GLN A 1 110 ? -20.24436 -23.17076 23.33971  1.000 31.54712  ? 110 GLN A CA   1 
ATOM   1614 C C    . GLN A 1 110 ? -18.91932 -23.45502 22.63997  1.000 30.50667  ? 110 GLN A C    1 
ATOM   1615 O O    . GLN A 1 110 ? -18.71624 -23.11717 21.47163  1.000 30.96338  ? 110 GLN A O    1 
ATOM   1616 C CB   . GLN A 1 110 ? -21.11811 -24.41993 23.29160  1.000 35.03686  ? 110 GLN A CB   1 
ATOM   1617 C CG   . GLN A 1 110 ? -22.35220 -24.35325 24.15605  1.000 37.46075  ? 110 GLN A CG   1 
ATOM   1618 C CD   . GLN A 1 110 ? -22.95801 -25.72070 24.37650  1.000 46.78098  ? 110 GLN A CD   1 
ATOM   1619 O OE1  . GLN A 1 110 ? -23.84285 -26.15128 23.63341  1.000 43.26537  ? 110 GLN A OE1  1 
ATOM   1620 N NE2  . GLN A 1 110 ? -22.47635 -26.42024 25.39779  1.000 62.99556  ? 110 GLN A NE2  1 
ATOM   1621 H H    . GLN A 1 110 ? -21.54901 -22.25334 22.18327  1.000 36.92148  ? 110 GLN A H    1 
ATOM   1622 H HA   . GLN A 1 110 ? -20.06851 -22.95906 24.26985  1.000 38.59261  ? 110 GLN A HA   1 
ATOM   1623 H HB2  . GLN A 1 110 ? -21.40846 -24.55882 22.37656  1.000 42.78030  ? 110 GLN A HB2  1 
ATOM   1624 H HB3  . GLN A 1 110 ? -20.59116 -25.17727 23.59104  1.000 42.78030  ? 110 GLN A HB3  1 
ATOM   1625 H HG2  . GLN A 1 110 ? -22.11718 -23.98192 25.02079  1.000 45.68897  ? 110 GLN A HG2  1 
ATOM   1626 H HG3  . GLN A 1 110 ? -23.01559 -23.79302 23.72365  1.000 45.68897  ? 110 GLN A HG3  1 
ATOM   1627 H HE21 . GLN A 1 110 ? -21.85398 -26.08910 25.89034  1.000 76.33073  ? 110 GLN A HE21 1 
ATOM   1628 H HE22 . GLN A 1 110 ? -22.78686 -27.20429 25.56646  1.000 76.33073  ? 110 GLN A HE22 1 
ATOM   1629 N N    . THR A 1 111 ? -18.01926 -24.10455 23.36774  1.000 28.71634  ? 111 THR A N    1 
ATOM   1630 C CA   . THR A 1 111 ? -16.67821 -24.38612 22.88231  1.000 31.05925  ? 111 THR A CA   1 
ATOM   1631 C C    . THR A 1 111 ? -16.49956 -25.87616 22.63099  1.000 28.65190  ? 111 THR A C    1 
ATOM   1632 O O    . THR A 1 111 ? -17.26851 -26.71149 23.11475  1.000 31.42194  ? 111 THR A O    1 
ATOM   1633 C CB   . THR A 1 111 ? -15.62470 -23.90065 23.88473  1.000 31.77605  ? 111 THR A CB   1 
ATOM   1634 O OG1  . THR A 1 111 ? -15.90996 -24.44752 25.17956  1.000 30.53304  ? 111 THR A OG1  1 
ATOM   1635 C CG2  . THR A 1 111 ? -15.61805 -22.37639 23.95041  1.000 32.92126  ? 111 THR A CG2  1 
ATOM   1636 H H    . THR A 1 111 ? -18.16698 -24.39765 24.16264  1.000 35.19567  ? 111 THR A H    1 
ATOM   1637 H HA   . THR A 1 111 ? -16.54219 -23.92264 22.04113  1.000 38.00716  ? 111 THR A HA   1 
ATOM   1638 H HB   . THR A 1 111 ? -14.74278 -24.19249 23.60555  1.000 38.86733  ? 111 THR A HB   1 
ATOM   1639 H HG1  . THR A 1 111 ? -15.33200 -24.19207 25.73301  1.000 37.37571  ? 111 THR A HG1  1 
ATOM   1640 H HG21 . THR A 1 111 ? -14.98100 -22.07583 24.61730  1.000 40.24158  ? 111 THR A HG21 1 
ATOM   1641 H HG22 . THR A 1 111 ? -15.36861 -22.00826 23.08835  1.000 40.24158  ? 111 THR A HG22 1 
ATOM   1642 H HG23 . THR A 1 111 ? -16.50020 -22.05072 24.18844  1.000 40.24158  ? 111 THR A HG23 1 
ATOM   1643 N N    . PHE A 1 112 ? -15.46381 -26.19440 21.85950  1.000 28.81307  ? 112 PHE A N    1 
ATOM   1644 C CA   . PHE A 1 112 ? -15.10731 -27.57776 21.58588  1.000 28.25988  ? 112 PHE A CA   1 
ATOM   1645 C C    . PHE A 1 112 ? -13.69920 -27.61047 21.01323  1.000 28.60478  ? 112 PHE A C    1 
ATOM   1646 O O    . PHE A 1 112 ? -13.17153 -26.59523 20.55251  1.000 29.29582  ? 112 PHE A O    1 
ATOM   1647 C CB   . PHE A 1 112 ? -16.11012 -28.23722 20.63129  1.000 26.14207  ? 112 PHE A CB   1 
ATOM   1648 C CG   . PHE A 1 112 ? -16.25612 -27.53321 19.30973  1.000 27.25206  ? 112 PHE A CG   1 
ATOM   1649 C CD1  . PHE A 1 112 ? -15.40662 -27.82816 18.26019  1.000 25.80516  ? 112 PHE A CD1  1 
ATOM   1650 C CD2  . PHE A 1 112 ? -17.25343 -26.59505 19.11137  1.000 28.32896  ? 112 PHE A CD2  1 
ATOM   1651 C CE1  . PHE A 1 112 ? -15.54189 -27.19284 17.03752  1.000 27.24741  ? 112 PHE A CE1  1 
ATOM   1652 C CE2  . PHE A 1 112 ? -17.39462 -25.95674 17.89312  1.000 26.97712  ? 112 PHE A CE2  1 
ATOM   1653 C CZ   . PHE A 1 112 ? -16.53577 -26.25655 16.85579  1.000 28.42964  ? 112 PHE A CZ   1 
ATOM   1654 H H    . PHE A 1 112 ? -14.94826 -25.62003 21.48015  1.000 35.31175  ? 112 PHE A H    1 
ATOM   1655 H HA   . PHE A 1 112 ? -15.10615 -28.08453 22.41297  1.000 34.64792  ? 112 PHE A HA   1 
ATOM   1656 H HB2  . PHE A 1 112 ? -15.81678 -29.14404 20.45096  1.000 32.10655  ? 112 PHE A HB2  1 
ATOM   1657 H HB3  . PHE A 1 112 ? -16.98187 -28.24891 21.05652  1.000 32.10655  ? 112 PHE A HB3  1 
ATOM   1658 H HD1  . PHE A 1 112 ? -14.73560 -28.46144 18.37673  1.000 31.70226  ? 112 PHE A HD1  1 
ATOM   1659 H HD2  . PHE A 1 112 ? -17.83649 -26.39111 19.80660  1.000 34.73082  ? 112 PHE A HD2  1 
ATOM   1660 H HE1  . PHE A 1 112 ? -14.96238 -27.39798 16.33968  1.000 33.43296  ? 112 PHE A HE1  1 
ATOM   1661 H HE2  . PHE A 1 112 ? -18.06757 -25.32617 17.77304  1.000 33.10861  ? 112 PHE A HE2  1 
ATOM   1662 H HZ   . PHE A 1 112 ? -16.62765 -25.82751 16.03580  1.000 34.85164  ? 112 PHE A HZ   1 
ATOM   1663 N N    . SER A 1 113 ? -13.08946 -28.79129 21.07345  1.000 25.89097  ? 113 SER A N    1 
ATOM   1664 C CA   . SER A 1 113 ? -11.75449 -29.00676 20.53297  1.000 25.97313  ? 113 SER A CA   1 
ATOM   1665 C C    . SER A 1 113 ? -11.86424 -29.52093 19.10703  1.000 26.39611  ? 113 SER A C    1 
ATOM   1666 O O    . SER A 1 113 ? -12.73081 -30.34438 18.80690  1.000 25.63387  ? 113 SER A O    1 
ATOM   1667 C CB   . SER A 1 113 ? -10.97241 -30.01151 21.38141  1.000 28.58353  ? 113 SER A CB   1 
ATOM   1668 O OG   . SER A 1 113 ? -10.70325 -29.50279 22.67287  1.000 29.87908  ? 113 SER A OG   1 
ATOM   1669 H H    . SER A 1 113 ? -13.43555 -29.49385 21.42874  1.000 31.80523  ? 113 SER A H    1 
ATOM   1670 H HA   . SER A 1 113 ? -11.26485 -28.16941 20.53603  1.000 31.90383  ? 113 SER A HA   1 
ATOM   1671 H HB2  . SER A 1 113 ? -11.49666 -30.82305 21.46782  1.000 35.03631  ? 113 SER A HB2  1 
ATOM   1672 H HB3  . SER A 1 113 ? -10.13080 -30.20565 20.93994  1.000 35.03631  ? 113 SER A HB3  1 
ATOM   1673 H HG   . SER A 1 113 ? -10.16768 -28.85769 22.62167  1.000 36.59096  ? 113 SER A HG   1 
ATOM   1674 N N    . VAL A 1 114 ? -10.98310 -29.03849 18.23355  1.000 25.75746  ? 114 VAL A N    1 
ATOM   1675 C CA   . VAL A 1 114 ? -10.89008 -29.52302 16.86332  1.000 26.40516  ? 114 VAL A CA   1 
ATOM   1676 C C    . VAL A 1 114 ? -9.59246  -30.30139 16.72099  1.000 26.64207  ? 114 VAL A C    1 
ATOM   1677 O O    . VAL A 1 114 ? -8.52203  -29.81309 17.10201  1.000 26.59631  ? 114 VAL A O    1 
ATOM   1678 C CB   . VAL A 1 114 ? -10.94814 -28.37809 15.83852  1.000 27.53806  ? 114 VAL A CB   1 
ATOM   1679 C CG1  . VAL A 1 114 ? -10.66404 -28.91135 14.43239  1.000 27.49414  ? 114 VAL A CG1  1 
ATOM   1680 C CG2  . VAL A 1 114 ? -12.29683 -27.68909 15.89437  1.000 27.37331  ? 114 VAL A CG2  1 
ATOM   1681 H H    . VAL A 1 114 ? -10.41800 -28.41703 18.41811  1.000 31.64502  ? 114 VAL A H    1 
ATOM   1682 H HA   . VAL A 1 114 ? -11.63586 -30.11922 16.69229  1.000 32.42226  ? 114 VAL A HA   1 
ATOM   1683 H HB   . VAL A 1 114 ? -10.26783 -27.72105 16.05388  1.000 33.78174  ? 114 VAL A HB   1 
ATOM   1684 H HG11 . VAL A 1 114 ? -10.95679 -28.25523 13.78069  1.000 33.72904  ? 114 VAL A HG11 1 
ATOM   1685 H HG12 . VAL A 1 114 ? -9.71103  -29.06676 14.34016  1.000 33.72904  ? 114 VAL A HG12 1 
ATOM   1686 H HG13 . VAL A 1 114 ? -11.14845 -29.74216 14.30587  1.000 33.72904  ? 114 VAL A HG13 1 
ATOM   1687 H HG21 . VAL A 1 114 ? -12.31526 -26.97714 15.23581  1.000 33.58404  ? 114 VAL A HG21 1 
ATOM   1688 H HG22 . VAL A 1 114 ? -12.99118 -28.33783 15.69967  1.000 33.58404  ? 114 VAL A HG22 1 
ATOM   1689 H HG23 . VAL A 1 114 ? -12.42717 -27.32156 16.78254  1.000 33.58404  ? 114 VAL A HG23 1 
ATOM   1690 N N    . LEU A 1 115 ? -9.69251  -31.51165 16.18347  1.000 25.62200  ? 115 LEU A N    1 
ATOM   1691 C CA   . LEU A 1 115 ? -8.53571  -32.29969 15.77458  1.000 25.07466  ? 115 LEU A CA   1 
ATOM   1692 C C    . LEU A 1 115 ? -8.39370  -32.12196 14.26606  1.000 26.96550  ? 115 LEU A C    1 
ATOM   1693 O O    . LEU A 1 115 ? -9.10099  -32.76395 13.48622  1.000 26.62020  ? 115 LEU A O    1 
ATOM   1694 C CB   . LEU A 1 115 ? -8.70918  -33.76248 16.16531  1.000 25.69040  ? 115 LEU A CB   1 
ATOM   1695 C CG   . LEU A 1 115 ? -7.50917  -34.64326 15.80914  1.000 27.69638  ? 115 LEU A CG   1 
ATOM   1696 C CD1  . LEU A 1 115 ? -6.25593  -34.18002 16.54907  1.000 27.66614  ? 115 LEU A CD1  1 
ATOM   1697 C CD2  . LEU A 1 115 ? -7.79037  -36.11288 16.09471  1.000 27.62568  ? 115 LEU A CD2  1 
ATOM   1698 H H    . LEU A 1 115 ? -10.44177 -31.90918 16.04145  1.000 31.48247  ? 115 LEU A H    1 
ATOM   1699 H HA   . LEU A 1 115 ? -7.73297  -31.97262 16.20994  1.000 30.82566  ? 115 LEU A HA   1 
ATOM   1700 H HB2  . LEU A 1 115 ? -8.84093  -33.81457 17.12491  1.000 31.56454  ? 115 LEU A HB2  1 
ATOM   1701 H HB3  . LEU A 1 115 ? -9.48510  -34.11768 15.70414  1.000 31.56454  ? 115 LEU A HB3  1 
ATOM   1702 H HG   . LEU A 1 115 ? -7.34531  -34.55910 14.85679  1.000 33.97172  ? 115 LEU A HG   1 
ATOM   1703 H HD11 . LEU A 1 115 ? -5.56988  -34.86059 16.46502  1.000 33.93544  ? 115 LEU A HD11 1 
ATOM   1704 H HD12 . LEU A 1 115 ? -5.94680  -33.34850 16.15675  1.000 33.93544  ? 115 LEU A HD12 1 
ATOM   1705 H HD13 . LEU A 1 115 ? -6.47372  -34.04362 17.48441  1.000 33.93544  ? 115 LEU A HD13 1 
ATOM   1706 H HD21 . LEU A 1 115 ? -7.02961  -36.64162 15.80732  1.000 33.88689  ? 115 LEU A HD21 1 
ATOM   1707 H HD22 . LEU A 1 115 ? -7.93223  -36.22796 17.04735  1.000 33.88689  ? 115 LEU A HD22 1 
ATOM   1708 H HD23 . LEU A 1 115 ? -8.58414  -36.38309 15.60706  1.000 33.88689  ? 115 LEU A HD23 1 
ATOM   1709 N N    . ALA A 1 116 ? -7.49172  -31.22855 13.86098  1.000 28.77007  ? 116 ALA A N    1 
ATOM   1710 C CA   . ALA A 1 116 ? -7.23423  -30.99955 12.44547  1.000 29.38952  ? 116 ALA A CA   1 
ATOM   1711 C C    . ALA A 1 116 ? -6.43332  -32.15191 11.85854  1.000 31.45002  ? 116 ALA A C    1 
ATOM   1712 O O    . ALA A 1 116 ? -5.44409  -32.60133 12.44432  1.000 33.08470  ? 116 ALA A O    1 
ATOM   1713 C CB   . ALA A 1 116 ? -6.47188  -29.68892 12.24620  1.000 30.36667  ? 116 ALA A CB   1 
ATOM   1714 H H    . ALA A 1 116 ? -7.01623  -30.74276 14.38777  1.000 35.26015  ? 116 ALA A H    1 
ATOM   1715 H HA   . ALA A 1 116 ? -8.07927  -30.93596 11.97349  1.000 36.00350  ? 116 ALA A HA   1 
ATOM   1716 H HB1  . ALA A 1 116 ? -6.31456  -29.55607 11.29831  1.000 37.17607  ? 116 ALA A HB1  1 
ATOM   1717 H HB2  . ALA A 1 116 ? -7.00294  -28.95790 12.59901  1.000 37.17607  ? 116 ALA A HB2  1 
ATOM   1718 H HB3  . ALA A 1 116 ? -5.62585  -29.74084 12.71783  1.000 37.17607  ? 116 ALA A HB3  1 
ATOM   1719 N N    . CYS A 1 117 ? -6.84737  -32.61079 10.67877  1.000 32.86420  ? 117 CYS A N    1 
ATOM   1720 C CA   . CYS A 1 117 ? -6.24526  -33.77713 10.05548  1.000 37.06635  ? 117 CYS A CA   1 
ATOM   1721 C C    . CYS A 1 117 ? -6.01766  -33.52760 8.57229   1.000 41.50020  ? 117 CYS A C    1 
ATOM   1722 O O    . CYS A 1 117 ? -6.55451  -32.58493 7.98638   1.000 41.29239  ? 117 CYS A O    1 
ATOM   1723 C CB   . CYS A 1 117 ? -7.12240  -35.02408 10.23641  1.000 35.36190  ? 117 CYS A CB   1 
ATOM   1724 S SG   . CYS A 1 117 ? -7.37271  -35.52161 11.94357  1.000 31.77982  ? 117 CYS A SG   1 
ATOM   1725 H H    . CYS A 1 117 ? -7.48206  -32.25713 10.21865  1.000 40.17311  ? 117 CYS A H    1 
ATOM   1726 H HA   . CYS A 1 117 ? -5.38116  -33.92565 10.47041  1.000 45.21569  ? 117 CYS A HA   1 
ATOM   1727 H HB2  . CYS A 1 117 ? -7.99523  -34.84538 9.85283   1.000 43.17035  ? 117 CYS A HB2  1 
ATOM   1728 H HB3  . CYS A 1 117 ? -6.70244  -35.76619 9.77403   1.000 43.17035  ? 117 CYS A HB3  1 
ATOM   1729 H HG   . CYS A 1 117 ? -8.32906  -34.94472 12.38242  1.000 38.87185  ? 117 CYS A HG   1 
ATOM   1730 N N    . TYR A 1 118 ? -5.21040  -34.40216 7.97070   1.000 43.65735  ? 118 TYR A N    1 
ATOM   1731 C CA   . TYR A 1 118 ? -4.95536  -34.38827 6.53353   1.000 48.25851  ? 118 TYR A CA   1 
ATOM   1732 C C    . TYR A 1 118 ? -4.63918  -35.81309 6.10215   1.000 51.80526  ? 118 TYR A C    1 
ATOM   1733 O O    . TYR A 1 118 ? -3.67734  -36.40954 6.59825   1.000 52.91103  ? 118 TYR A O    1 
ATOM   1734 C CB   . TYR A 1 118 ? -3.80290  -33.44775 6.17898   1.000 57.78994  ? 118 TYR A CB   1 
ATOM   1735 H H    . TYR A 1 118 ? -4.78936  -35.02759 8.38442   1.000 53.12489  ? 118 TYR A H    1 
ATOM   1736 H HA   . TYR A 1 118 ? -5.74679  -34.08216 6.06361   1.000 58.64628  ? 118 TYR A HA   1 
ATOM   1737 N N    . ASN A 1 119 ? -5.45457  -36.35838 5.19585   1.000 51.49454  ? 119 ASN A N    1 
ATOM   1738 C CA   . ASN A 1 119 ? -5.28288  -37.72435 4.69576   1.000 56.02967  ? 119 ASN A CA   1 
ATOM   1739 C C    . ASN A 1 119 ? -5.49204  -38.75135 5.80588   1.000 52.93469  ? 119 ASN A C    1 
ATOM   1740 O O    . ASN A 1 119 ? -4.81481  -39.77961 5.86645   1.000 53.11320  ? 119 ASN A O    1 
ATOM   1741 C CB   . ASN A 1 119 ? -3.91099  -37.89828 4.04347   1.000 58.32721  ? 119 ASN A CB   1 
ATOM   1742 C CG   . ASN A 1 119 ? -3.70806  -36.96721 2.86474   1.000 62.41140  ? 119 ASN A CG   1 
ATOM   1743 O OD1  . ASN A 1 119 ? -2.92386  -36.02134 2.93489   1.000 66.37602  ? 119 ASN A OD1  1 
ATOM   1744 N ND2  . ASN A 1 119 ? -4.42343  -37.22497 1.77581   1.000 64.09742  ? 119 ASN A ND2  1 
ATOM   1745 H H    . ASN A 1 119 ? -6.12698  -35.94944 4.84911   1.000 62.52951  ? 119 ASN A H    1 
ATOM   1746 H HA   . ASN A 1 119 ? -5.95905  -37.89057 4.02044   1.000 67.97168  ? 119 ASN A HA   1 
ATOM   1747 H HB2  . ASN A 1 119 ? -3.22167  -37.70884 4.69910   1.000 70.72872  ? 119 ASN A HB2  1 
ATOM   1748 H HB3  . ASN A 1 119 ? -3.82441  -38.81046 3.72516   1.000 70.72872  ? 119 ASN A HB3  1 
ATOM   1749 H HD21 . ASN A 1 119 ? -4.34357  -36.72512 1.08056   1.000 77.65298  ? 119 ASN A HD21 1 
ATOM   1750 H HD22 . ASN A 1 119 ? -4.96652  -37.89173 1.76596   1.000 77.65298  ? 119 ASN A HD22 1 
ATOM   1751 N N    . GLY A 1 120 ? -6.44879  -38.47736 6.68642   1.000 47.83545  ? 120 GLY A N    1 
ATOM   1752 C CA   . GLY A 1 120 ? -6.76371  -39.36736 7.77537   1.000 48.05320  ? 120 GLY A CA   1 
ATOM   1753 C C    . GLY A 1 120 ? -5.78339  -39.34895 8.92744   1.000 45.15969  ? 120 GLY A C    1 
ATOM   1754 O O    . GLY A 1 120 ? -5.94088  -40.15113 9.86223   1.000 44.29871  ? 120 GLY A O    1 
ATOM   1755 H H    . GLY A 1 120 ? -6.93363  -37.76732 6.66698   1.000 58.13861  ? 120 GLY A H    1 
ATOM   1756 H HA2  . GLY A 1 120 ? -7.63567  -39.12889 8.12713   1.000 58.39991  ? 120 GLY A HA2  1 
ATOM   1757 H HA3  . GLY A 1 120 ? -6.79852  -40.27430 7.43309   1.000 58.39991  ? 120 GLY A HA3  1 
ATOM   1758 N N    . SER A 1 121 ? -4.78292  -38.45748 8.90490   1.000 42.36643  ? 121 SER A N    1 
ATOM   1759 C CA   . SER A 1 121 ? -3.77316  -38.40508 9.95172   1.000 43.76251  ? 121 SER A CA   1 
ATOM   1760 C C    . SER A 1 121 ? -3.85355  -37.09542 10.72966  1.000 41.23522  ? 121 SER A C    1 
ATOM   1761 O O    . SER A 1 121 ? -4.01655  -36.02689 10.12972  1.000 38.67603  ? 121 SER A O    1 
ATOM   1762 C CB   . SER A 1 121 ? -2.37036  -38.55087 9.35124   1.000 47.33942  ? 121 SER A CB   1 
ATOM   1763 O OG   . SER A 1 121 ? -2.16208  -39.86339 8.85040   1.000 53.52846  ? 121 SER A OG   1 
ATOM   1764 H H    . SER A 1 121 ? -4.67275  -37.87082 8.28580   1.000 51.57579  ? 121 SER A H    1 
ATOM   1765 H HA   . SER A 1 121 ? -3.92078  -39.13162 10.57721  1.000 53.25108  ? 121 SER A HA   1 
ATOM   1766 H HB2  . SER A 1 121 ? -2.27217  -37.91711 8.62350   1.000 57.54337  ? 121 SER A HB2  1 
ATOM   1767 H HB3  . SER A 1 121 ? -1.71256  -38.36904 10.04055  1.000 57.54337  ? 121 SER A HB3  1 
ATOM   1768 H HG   . SER A 1 121 ? -1.34537  -39.98613 8.69704   1.000 64.97022  ? 121 SER A HG   1 
ATOM   1769 N N    . PRO A 1 122 ? -3.74462  -37.14580 12.05898  1.000 39.07760  ? 122 PRO A N    1 
ATOM   1770 C CA   . PRO A 1 122 ? -3.87503  -35.91436 12.84800  1.000 35.03441  ? 122 PRO A CA   1 
ATOM   1771 C C    . PRO A 1 122 ? -2.68570  -34.98305 12.68619  1.000 37.06359  ? 122 PRO A C    1 
ATOM   1772 O O    . PRO A 1 122 ? -1.52772  -35.40772 12.70597  1.000 40.39919  ? 122 PRO A O    1 
ATOM   1773 C CB   . PRO A 1 122 ? -3.97755  -36.41957 14.29635  1.000 36.62587  ? 122 PRO A CB   1 
ATOM   1774 C CG   . PRO A 1 122 ? -4.37678  -37.84980 14.18581  1.000 37.33758  ? 122 PRO A CG   1 
ATOM   1775 C CD   . PRO A 1 122 ? -3.74098  -38.34549 12.91540  1.000 37.23020  ? 122 PRO A CD   1 
ATOM   1776 H HA   . PRO A 1 122 ? -4.68602  -35.44847 12.59082  1.000 42.77736  ? 122 PRO A HA   1 
ATOM   1777 H HB2  . PRO A 1 122 ? -3.11747  -36.33335 14.73650  1.000 44.68711  ? 122 PRO A HB2  1 
ATOM   1778 H HB3  . PRO A 1 122 ? -4.64843  -35.90906 14.77614  1.000 44.68711  ? 122 PRO A HB3  1 
ATOM   1779 H HG2  . PRO A 1 122 ? -4.04653  -38.34370 14.95256  1.000 45.54117  ? 122 PRO A HG2  1 
ATOM   1780 H HG3  . PRO A 1 122 ? -5.34313  -37.91881 14.13787  1.000 45.54117  ? 122 PRO A HG3  1 
ATOM   1781 H HD2  . PRO A 1 122 ? -2.83559  -38.65351 13.07756  1.000 45.41231  ? 122 PRO A HD2  1 
ATOM   1782 H HD3  . PRO A 1 122 ? -4.26737  -39.05699 12.51844  1.000 45.41231  ? 122 PRO A HD3  1 
ATOM   1783 N N    . SER A 1 123 ? -2.99084  -33.68893 12.56645  1.000 34.81103  ? 123 SER A N    1 
ATOM   1784 C CA   . SER A 1 123 ? -1.98388  -32.64084 12.46396  1.000 37.39769  ? 123 SER A CA   1 
ATOM   1785 C C    . SER A 1 123 ? -1.83883  -31.83897 13.75500  1.000 36.58702  ? 123 SER A C    1 
ATOM   1786 O O    . SER A 1 123 ? -0.71549  -31.50694 14.14836  1.000 38.18171  ? 123 SER A O    1 
ATOM   1787 C CB   . SER A 1 123 ? -2.33397  -31.69846 11.31104  1.000 37.18042  ? 123 SER A CB   1 
ATOM   1788 O OG   . SER A 1 123 ? -1.37935  -30.66031 11.18232  1.000 46.74480  ? 123 SER A OG   1 
ATOM   1789 H H    . SER A 1 123 ? -3.79658  -33.38930 12.54195  1.000 42.50930  ? 123 SER A H    1 
ATOM   1790 H HA   . SER A 1 123 ? -1.12269  -33.04203 12.26823  1.000 45.61329  ? 123 SER A HA   1 
ATOM   1791 H HB2  . SER A 1 123 ? -2.35614  -32.20777 10.48581  1.000 45.35257  ? 123 SER A HB2  1 
ATOM   1792 H HB3  . SER A 1 123 ? -3.20395  -31.30474 11.48138  1.000 45.35257  ? 123 SER A HB3  1 
ATOM   1793 H HG   . SER A 1 123 ? -1.72229  -30.00174 10.78955  1.000 56.82983  ? 123 SER A HG   1 
ATOM   1794 N N    . GLY A 1 124 ? -2.94096  -31.52323 14.42517  1.000 32.76993  ? 124 GLY A N    1 
ATOM   1795 C CA   . GLY A 1 124 ? -2.86898  -30.72697 15.63730  1.000 31.78471  ? 124 GLY A CA   1 
ATOM   1796 C C    . GLY A 1 124 ? -4.24392  -30.55972 16.24067  1.000 29.80437  ? 124 GLY A C    1 
ATOM   1797 O O    . GLY A 1 124 ? -5.25487  -30.98589 15.67461  1.000 29.85633  ? 124 GLY A O    1 
ATOM   1798 H H    . GLY A 1 124 ? -3.73689  -31.75733 14.19869  1.000 40.05998  ? 124 GLY A H    1 
ATOM   1799 H HA2  . GLY A 1 124 ? -2.29370  -31.16394 16.28461  1.000 38.87772  ? 124 GLY A HA2  1 
ATOM   1800 H HA3  . GLY A 1 124 ? -2.50705  -29.85022 15.43428  1.000 38.87772  ? 124 GLY A HA3  1 
ATOM   1801 N N    . VAL A 1 125 ? -4.27228  -29.92313 17.40584  1.000 30.21799  ? 125 VAL A N    1 
ATOM   1802 C CA   . VAL A 1 125 ? -5.50759  -29.75792 18.16204  1.000 26.34338  ? 125 VAL A CA   1 
ATOM   1803 C C    . VAL A 1 125 ? -5.57850  -28.33138 18.68663  1.000 30.65757  ? 125 VAL A C    1 
ATOM   1804 O O    . VAL A 1 125 ? -4.57083  -27.76403 19.12194  1.000 31.06175  ? 125 VAL A O    1 
ATOM   1805 C CB   . VAL A 1 125 ? -5.60150  -30.78792 19.30940  1.000 28.31660  ? 125 VAL A CB   1 
ATOM   1806 C CG1  . VAL A 1 125 ? -4.52259  -30.53271 20.34727  1.000 31.80069  ? 125 VAL A CG1  1 
ATOM   1807 C CG2  . VAL A 1 125 ? -6.98162  -30.76348 19.94135  1.000 29.28224  ? 125 VAL A CG2  1 
ATOM   1808 H H    . VAL A 1 125 ? -3.58202  -29.57487 17.78247  1.000 36.99765  ? 125 VAL A H    1 
ATOM   1809 H HA   . VAL A 1 125 ? -6.26752  -29.88885 17.57361  1.000 32.34812  ? 125 VAL A HA   1 
ATOM   1810 H HB   . VAL A 1 125 ? -5.45893  -31.67526 18.94444  1.000 34.71599  ? 125 VAL A HB   1 
ATOM   1811 H HG11 . VAL A 1 125 ? -4.46369  -31.30063 20.93696  1.000 38.89689  ? 125 VAL A HG11 1 
ATOM   1812 H HG12 . VAL A 1 125 ? -3.67520  -30.39710 19.89512  1.000 38.89689  ? 125 VAL A HG12 1 
ATOM   1813 H HG13 . VAL A 1 125 ? -4.75582  -29.74120 20.85719  1.000 38.89689  ? 125 VAL A HG13 1 
ATOM   1814 H HG21 . VAL A 1 125 ? -7.03202  -31.45787 20.61677  1.000 35.87476  ? 125 VAL A HG21 1 
ATOM   1815 H HG22 . VAL A 1 125 ? -7.12732  -29.89508 20.34822  1.000 35.87476  ? 125 VAL A HG22 1 
ATOM   1816 H HG23 . VAL A 1 125 ? -7.64681  -30.92226 19.25344  1.000 35.87476  ? 125 VAL A HG23 1 
ATOM   1817 N N    . TYR A 1 126 ? -6.77563  -27.74815 18.62780  1.000 30.23387  ? 126 TYR A N    1 
ATOM   1818 C CA   . TYR A 1 126 ? -7.00322  -26.39521 19.10919  1.000 30.17594  ? 126 TYR A CA   1 
ATOM   1819 C C    . TYR A 1 126 ? -8.45377  -26.25372 19.55233  1.000 32.55309  ? 126 TYR A C    1 
ATOM   1820 O O    . TYR A 1 126 ? -9.34126  -26.96196 19.06768  1.000 28.58686  ? 126 TYR A O    1 
ATOM   1821 C CB   . TYR A 1 126 ? -6.66853  -25.35081 18.03448  1.000 31.56308  ? 126 TYR A CB   1 
ATOM   1822 C CG   . TYR A 1 126 ? -7.33192  -25.59139 16.69363  1.000 31.05018  ? 126 TYR A CG   1 
ATOM   1823 C CD1  . TYR A 1 126 ? -6.71617  -26.36434 15.71896  1.000 32.44940  ? 126 TYR A CD1  1 
ATOM   1824 C CD2  . TYR A 1 126 ? -8.56896  -25.03354 16.39804  1.000 32.82378  ? 126 TYR A CD2  1 
ATOM   1825 C CE1  . TYR A 1 126 ? -7.31707  -26.58187 14.48758  1.000 31.95465  ? 126 TYR A CE1  1 
ATOM   1826 C CE2  . TYR A 1 126 ? -9.17810  -25.24649 15.17123  1.000 34.18395  ? 126 TYR A CE2  1 
ATOM   1827 C CZ   . TYR A 1 126 ? -8.54878  -26.02082 14.21993  1.000 33.37354  ? 126 TYR A CZ   1 
ATOM   1828 O OH   . TYR A 1 126 ? -9.15385  -26.22953 13.00003  1.000 38.76708  ? 126 TYR A OH   1 
ATOM   1829 H H    . TYR A 1 126 ? -7.47976  -28.12433 18.30797  1.000 37.01672  ? 126 TYR A H    1 
ATOM   1830 H HA   . TYR A 1 126 ? -6.43868  -26.23001 19.88049  1.000 36.94720  ? 126 TYR A HA   1 
ATOM   1831 H HB2  . TYR A 1 126 ? -6.95525  -24.47977 18.35066  1.000 38.61177  ? 126 TYR A HB2  1 
ATOM   1832 H HB3  . TYR A 1 126 ? -5.70924  -25.35232 17.89076  1.000 38.61177  ? 126 TYR A HB3  1 
ATOM   1833 H HD1  . TYR A 1 126 ? -5.88533  -26.74348 15.89464  1.000 39.67535  ? 126 TYR A HD1  1 
ATOM   1834 H HD2  . TYR A 1 126 ? -8.99643  -24.50752 17.03480  1.000 40.12460  ? 126 TYR A HD2  1 
ATOM   1835 H HE1  . TYR A 1 126 ? -6.89170  -27.10333 13.84568  1.000 39.08165  ? 126 TYR A HE1  1 
ATOM   1836 H HE2  . TYR A 1 126 ? -10.00833 -24.86837 14.99054  1.000 41.75681  ? 126 TYR A HE2  1 
ATOM   1837 H HH   . TYR A 1 126 ? -8.60444  -26.56517 12.46050  1.000 47.25657  ? 126 TYR A HH   1 
ATOM   1838 N N    . GLN A 1 127 ? -8.67357  -25.32793 20.48709  1.000 31.03052  ? 127 GLN A N    1 
ATOM   1839 C CA   . GLN A 1 127 ? -9.98807  -25.03433 21.04490  1.000 31.61209  ? 127 GLN A CA   1 
ATOM   1840 C C    . GLN A 1 127 ? -10.63210 -23.88960 20.27736  1.000 35.93069  ? 127 GLN A C    1 
ATOM   1841 O O    . GLN A 1 127 ? -9.96159  -22.92304 19.90672  1.000 37.51368  ? 127 GLN A O    1 
ATOM   1842 C CB   . GLN A 1 127 ? -9.85413  -24.66348 22.52603  1.000 32.70348  ? 127 GLN A CB   1 
ATOM   1843 C CG   . GLN A 1 127 ? -11.15565 -24.59688 23.30486  1.000 32.36402  ? 127 GLN A CG   1 
ATOM   1844 C CD   . GLN A 1 127 ? -11.63215 -25.96350 23.73897  1.000 32.28041  ? 127 GLN A CD   1 
ATOM   1845 O OE1  . GLN A 1 127 ? -11.20328 -26.98216 23.19847  1.000 34.08024  ? 127 GLN A OE1  1 
ATOM   1846 N NE2  . GLN A 1 127 ? -12.51799 -25.99517 24.72833  1.000 34.00318  ? 127 GLN A NE2  1 
ATOM   1847 H H    . GLN A 1 127 ? -8.05194  -24.83938 20.82547  1.000 37.97269  ? 127 GLN A H    1 
ATOM   1848 H HA   . GLN A 1 127 ? -10.56347 -25.81178 20.97146  1.000 38.67058  ? 127 GLN A HA   1 
ATOM   1849 H HB2  . GLN A 1 127 ? -9.29375  -25.32763 22.95705  1.000 39.98025  ? 127 GLN A HB2  1 
ATOM   1850 H HB3  . GLN A 1 127 ? -9.43773  -23.78938 22.58491  1.000 39.98025  ? 127 GLN A HB3  1 
ATOM   1851 H HG2  . GLN A 1 127 ? -11.02370 -24.05632 24.09940  1.000 39.57289  ? 127 GLN A HG2  1 
ATOM   1852 H HG3  . GLN A 1 127 ? -11.84176 -24.20141 22.74472  1.000 39.57289  ? 127 GLN A HG3  1 
ATOM   1853 H HE21 . GLN A 1 127 ? -12.78974 -25.26172 25.08584  1.000 41.53988  ? 127 GLN A HE21 1 
ATOM   1854 H HE22 . GLN A 1 127 ? -12.81976 -26.74911 25.01136  1.000 41.53988  ? 127 GLN A HE22 1 
ATOM   1855 N N    A CYS A 1 128 ? -11.93855 -23.97703 20.07492  0.500 32.85292  ? 128 CYS A N    1 
ATOM   1856 N N    B CYS A 1 128 ? -11.93489 -24.02946 20.01700  0.500 33.71532  ? 128 CYS A N    1 
ATOM   1857 C CA   A CYS A 1 128 ? -12.62577 -22.89525 19.39556  0.500 34.40872  ? 128 CYS A CA   1 
ATOM   1858 C CA   B CYS A 1 128 ? -12.70997 -23.06738 19.24623  0.500 34.27842  ? 128 CYS A CA   1 
ATOM   1859 C C    A CYS A 1 128 ? -14.06771 -22.83803 19.85974  0.500 36.34559  ? 128 CYS A C    1 
ATOM   1860 C C    B CYS A 1 128 ? -14.03653 -22.80016 19.94925  0.500 32.88479  ? 128 CYS A C    1 
ATOM   1861 O O    A CYS A 1 128 ? -14.59258 -23.77092 20.47399  0.500 31.03825  ? 128 CYS A O    1 
ATOM   1862 O O    B CYS A 1 128 ? -14.43765 -23.53930 20.84864  0.500 31.38213  ? 128 CYS A O    1 
ATOM   1863 C CB   A CYS A 1 128 ? -12.56732 -23.05782 17.87680  0.500 35.63316  ? 128 CYS A CB   1 
ATOM   1864 C CB   B CYS A 1 128 ? -13.01345 -23.57158 17.81978  0.500 34.46676  ? 128 CYS A CB   1 
ATOM   1865 S SG   A CYS A 1 128 ? -13.49153 -24.48812 17.30727  0.500 33.99355  ? 128 CYS A SG   1 
ATOM   1866 S SG   B CYS A 1 128 ? -11.64268 -23.59876 16.64574  0.500 35.81064  ? 128 CYS A SG   1 
ATOM   1867 H H    A CYS A 1 128 ? -12.43499 -24.63655 20.31613  0.500 40.15957  ? 128 CYS A H    1 
ATOM   1868 H H    B CYS A 1 128 ? -12.40401 -24.69765 20.28727  0.500 41.19445  ? 128 CYS A H    1 
ATOM   1869 H HA   A CYS A 1 128 ? -12.19431 -22.06131 19.63907  0.500 42.02653  ? 128 CYS A HA   1 
ATOM   1870 H HA   B CYS A 1 128 ? -12.19938 -22.24435 19.19309  0.500 41.87017  ? 128 CYS A HA   1 
ATOM   1871 H HB2  A CYS A 1 128 ? -12.94456 -22.26810 17.45855  0.500 43.49586  ? 128 CYS A HB2  1 
ATOM   1872 H HB2  B CYS A 1 128 ? -13.34308 -24.48124 17.88874  0.500 42.09618  ? 128 CYS A HB2  1 
ATOM   1873 H HB3  A CYS A 1 128 ? -11.64269 -23.16762 17.60494  0.500 43.49586  ? 128 CYS A HB3  1 
ATOM   1874 H HB3  B CYS A 1 128 ? -13.69789 -22.99858 17.44015  0.500 42.09618  ? 128 CYS A HB3  1 
ATOM   1875 H HG   A CYS A 1 128 ? -13.34335 -24.60236 16.12195  0.500 41.52832  ? 128 CYS A HG   1 
ATOM   1876 H HG   B CYS A 1 128 ? -12.05084 -23.96069 15.57690  0.500 43.70883  ? 128 CYS A HG   1 
ATOM   1877 N N    . ALA A 1 129 ? -14.69837 -21.71466 19.55450  1.000 33.71788  ? 129 ALA A N    1 
ATOM   1878 C CA   . ALA A 1 129 ? -16.08051 -21.45786 19.91547  1.000 31.98129  ? 129 ALA A CA   1 
ATOM   1879 C C    . ALA A 1 129 ? -16.95388 -21.49041 18.67246  1.000 30.24013  ? 129 ALA A C    1 
ATOM   1880 O O    . ALA A 1 129 ? -16.51471 -21.10243 17.58819  1.000 31.55105  ? 129 ALA A O    1 
ATOM   1881 C CB   . ALA A 1 129 ? -16.19989 -20.09778 20.61077  1.000 32.47781  ? 129 ALA A CB   1 
ATOM   1882 H H    . ALA A 1 129 ? -14.33602 -21.06397 19.12451  1.000 41.19753  ? 129 ALA A H    1 
ATOM   1883 H HA   . ALA A 1 129 ? -16.40198 -22.14566 20.51920  1.000 39.11362  ? 129 ALA A HA   1 
ATOM   1884 H HB1  . ALA A 1 129 ? -17.12919 -19.94094 20.84031  1.000 39.70944  ? 129 ALA A HB1  1 
ATOM   1885 H HB2  . ALA A 1 129 ? -15.65731 -20.10544 21.41479  1.000 39.70944  ? 129 ALA A HB2  1 
ATOM   1886 H HB3  . ALA A 1 129 ? -15.88697 -19.40597 20.00713  1.000 39.70944  ? 129 ALA A HB3  1 
ATOM   1887 N N    . MET A 1 130 ? -18.17913 -21.97985 18.82379  1.000 29.40202  ? 130 MET A N    1 
ATOM   1888 C CA   . MET A 1 130 ? -19.19772 -21.78472 17.79747  1.000 28.57593  ? 130 MET A CA   1 
ATOM   1889 C C    . MET A 1 130 ? -19.66848 -20.33741 17.87635  1.000 29.29041  ? 130 MET A C    1 
ATOM   1890 O O    . MET A 1 130 ? -20.35671 -19.95648 18.82928  1.000 30.39692  ? 130 MET A O    1 
ATOM   1891 C CB   . MET A 1 130 ? -20.35323 -22.75577 18.00488  1.000 28.55189  ? 130 MET A CB   1 
ATOM   1892 C CG   . MET A 1 130 ? -21.47667 -22.62567 16.99217  1.000 30.80376  ? 130 MET A CG   1 
ATOM   1893 S SD   . MET A 1 130 ? -20.92588 -22.94267 15.30355  1.000 29.02750  ? 130 MET A SD   1 
ATOM   1894 C CE   . MET A 1 130 ? -20.50876 -24.68110 15.41144  1.000 26.19356  ? 130 MET A CE   1 
ATOM   1895 H H    . MET A 1 130 ? -18.44521 -22.42682 19.50864  1.000 36.01849  ? 130 MET A H    1 
ATOM   1896 H HA   . MET A 1 130 ? -18.82583 -21.96809 16.92055  1.000 35.02719  ? 130 MET A HA   1 
ATOM   1897 H HB2  . MET A 1 130 ? -20.00986 -23.66108 17.94638  1.000 34.99834  ? 130 MET A HB2  1 
ATOM   1898 H HB3  . MET A 1 130 ? -20.73243 -22.60095 18.88416  1.000 34.99834  ? 130 MET A HB3  1 
ATOM   1899 H HG2  . MET A 1 130 ? -22.17264 -23.26631 17.20691  1.000 37.70058  ? 130 MET A HG2  1 
ATOM   1900 H HG3  . MET A 1 130 ? -21.83297 -21.72420 17.02821  1.000 37.70058  ? 130 MET A HG3  1 
ATOM   1901 H HE1  . MET A 1 130 ? -20.28085 -25.00669 14.52660  1.000 32.16834  ? 130 MET A HE1  1 
ATOM   1902 H HE2  . MET A 1 130 ? -19.75161 -24.78775 16.00831  1.000 32.16834  ? 130 MET A HE2  1 
ATOM   1903 H HE3  . MET A 1 130 ? -21.27318 -25.16846 15.75649  1.000 32.16834  ? 130 MET A HE3  1 
ATOM   1904 N N    . ARG A 1 131 ? -19.27018 -19.51322 16.90115  1.000 29.23736  ? 131 ARG A N    1 
ATOM   1905 C CA   . ARG A 1 131 ? -19.62111 -18.10185 16.94459  1.000 30.15789  ? 131 ARG A CA   1 
ATOM   1906 C C    . ARG A 1 131 ? -21.14069 -17.94223 17.00375  1.000 31.06681  ? 131 ARG A C    1 
ATOM   1907 O O    . ARG A 1 131 ? -21.88671 -18.84888 16.62235  1.000 30.83333  ? 131 ARG A O    1 
ATOM   1908 C CB   . ARG A 1 131 ? -19.06731 -17.36485 15.72409  1.000 30.51512  ? 131 ARG A CB   1 
ATOM   1909 C CG   . ARG A 1 131 ? -17.55500 -17.46671 15.51267  1.000 33.50019  ? 131 ARG A CG   1 
ATOM   1910 C CD   . ARG A 1 131 ? -16.75531 -17.05194 16.73920  1.000 32.50886  ? 131 ARG A CD   1 
ATOM   1911 N NE   . ARG A 1 131 ? -17.13047 -15.73095 17.22890  1.000 31.42329  ? 131 ARG A NE   1 
ATOM   1912 C CZ   . ARG A 1 131 ? -16.77057 -15.24356 18.40785  1.000 31.96891  ? 131 ARG A CZ   1 
ATOM   1913 N NH1  . ARG A 1 131 ? -15.99096 -15.92852 19.22884  1.000 31.88283  ? 131 ARG A NH1  1 
ATOM   1914 N NH2  . ARG A 1 131 ? -17.21564 -14.04697 18.77906  1.000 31.43248  ? 131 ARG A NH2  1 
ATOM   1915 H H    . ARG A 1 131 ? -18.80408 -19.74779 16.21754  1.000 35.82090  ? 131 ARG A H    1 
ATOM   1916 H HA   . ARG A 1 131 ? -19.23320 -17.70002 17.73765  1.000 36.92554  ? 131 ARG A HA   1 
ATOM   1917 H HB2  . ARG A 1 131 ? -19.49315 -17.72726 14.93149  1.000 37.35422  ? 131 ARG A HB2  1 
ATOM   1918 H HB3  . ARG A 1 131 ? -19.28183 -16.42323 15.81481  1.000 37.35422  ? 131 ARG A HB3  1 
ATOM   1919 H HG2  . ARG A 1 131 ? -17.32653 -18.38602 15.30393  1.000 40.93629  ? 131 ARG A HG2  1 
ATOM   1920 H HG3  . ARG A 1 131 ? -17.29894 -16.88638 14.77881  1.000 40.93629  ? 131 ARG A HG3  1 
ATOM   1921 H HD2  . ARG A 1 131 ? -16.91114 -17.69218 17.45103  1.000 39.74669  ? 131 ARG A HD2  1 
ATOM   1922 H HD3  . ARG A 1 131 ? -15.81262 -17.03190 16.51151  1.000 39.74669  ? 131 ARG A HD3  1 
ATOM   1923 H HE   . ARG A 1 131 ? -17.61642 -15.23624 16.72026  1.000 38.44402  ? 131 ARG A HE   1 
ATOM   1924 H HH11 . ARG A 1 131 ? -15.70645 -16.70766 19.00169  1.000 38.99547  ? 131 ARG A HH11 1 
ATOM   1925 H HH12 . ARG A 1 131 ? -15.76879 -15.59455 19.98956  1.000 38.99547  ? 131 ARG A HH12 1 
ATOM   1926 H HH21 . ARG A 1 131 ? -17.73084 -13.59868 18.25639  1.000 38.45505  ? 131 ARG A HH21 1 
ATOM   1927 H HH22 . ARG A 1 131 ? -16.98832 -13.72128 19.54185  1.000 38.45505  ? 131 ARG A HH22 1 
ATOM   1928 N N    . PRO A 1 132 ? -21.62437 -16.80468 17.50773  1.000 30.59440  ? 132 PRO A N    1 
ATOM   1929 C CA   . PRO A 1 132 ? -23.06566 -16.52449 17.39652  1.000 31.28705  ? 132 PRO A CA   1 
ATOM   1930 C C    . PRO A 1 132 ? -23.60161 -16.66047 15.98250  1.000 30.31663  ? 132 PRO A C    1 
ATOM   1931 O O    . PRO A 1 132 ? -24.76281 -17.05681 15.81321  1.000 32.03758  ? 132 PRO A O    1 
ATOM   1932 C CB   . PRO A 1 132 ? -23.17561 -15.08607 17.91933  1.000 29.13785  ? 132 PRO A CB   1 
ATOM   1933 C CG   . PRO A 1 132 ? -22.08746 -15.00858 18.95554  1.000 30.11072  ? 132 PRO A CG   1 
ATOM   1934 C CD   . PRO A 1 132 ? -20.94063 -15.84215 18.39714  1.000 29.15480  ? 132 PRO A CD   1 
ATOM   1935 H HA   . PRO A 1 132 ? -23.56733 -17.11383 17.98124  1.000 38.28052  ? 132 PRO A HA   1 
ATOM   1936 H HB2  . PRO A 1 132 ? -23.02357 -14.45366 17.19971  1.000 35.70149  ? 132 PRO A HB2  1 
ATOM   1937 H HB3  . PRO A 1 132 ? -24.04942 -14.93676 18.31311  1.000 35.70149  ? 132 PRO A HB3  1 
ATOM   1938 H HG2  . PRO A 1 132 ? -21.81558 -14.08573 19.07935  1.000 36.86894  ? 132 PRO A HG2  1 
ATOM   1939 H HG3  . PRO A 1 132 ? -22.40517 -15.37632 19.79502  1.000 36.86894  ? 132 PRO A HG3  1 
ATOM   1940 H HD2  . PRO A 1 132 ? -20.32243 -15.28756 17.89599  1.000 35.72182  ? 132 PRO A HD2  1 
ATOM   1941 H HD3  . PRO A 1 132 ? -20.47021 -16.30348 19.10903  1.000 35.72182  ? 132 PRO A HD3  1 
ATOM   1942 N N    . ASN A 1 133 ? -22.80071 -16.35020 14.95881  1.000 31.25663  ? 133 ASN A N    1 
ATOM   1943 C CA   . ASN A 1 133 ? -23.23564 -16.47749 13.57380  1.000 29.81457  ? 133 ASN A CA   1 
ATOM   1944 C C    . ASN A 1 133 ? -22.91834 -17.84892 12.98328  1.000 28.91502  ? 133 ASN A C    1 
ATOM   1945 O O    . ASN A 1 133 ? -22.93505 -18.00766 11.75617  1.000 31.66780  ? 133 ASN A O    1 
ATOM   1946 C CB   . ASN A 1 133 ? -22.62353 -15.35972 12.71712  1.000 32.05019  ? 133 ASN A CB   1 
ATOM   1947 C CG   . ASN A 1 133 ? -21.13118 -15.52888 12.47894  1.000 33.02802  ? 133 ASN A CG   1 
ATOM   1948 O OD1  . ASN A 1 133 ? -20.50811 -16.47877 12.95543  1.000 31.64290  ? 133 ASN A OD1  1 
ATOM   1949 N ND2  . ASN A 1 133 ? -20.55136 -14.60054 11.72782  1.000 32.93165  ? 133 ASN A ND2  1 
ATOM   1950 H H    . ASN A 1 133 ? -21.99528 -16.06188 15.04684  1.000 38.24402  ? 133 ASN A H    1 
ATOM   1951 H HA   . ASN A 1 133 ? -24.19878 -16.36635 13.54371  1.000 36.51355  ? 133 ASN A HA   1 
ATOM   1952 H HB2  . ASN A 1 133 ? -23.06323 -15.35086 11.85254  1.000 39.19630  ? 133 ASN A HB2  1 
ATOM   1953 H HB3  . ASN A 1 133 ? -22.75829 -14.51076 13.16656  1.000 39.19630  ? 133 ASN A HB3  1 
ATOM   1954 H HD21 . ASN A 1 133 ? -19.70900 -14.64689 11.56083  1.000 40.25405  ? 133 ASN A HD21 1 
ATOM   1955 H HD22 . ASN A 1 133 ? -21.01808 -13.95277 11.40820  1.000 40.25405  ? 133 ASN A HD22 1 
ATOM   1956 N N    . PHE A 1 134 ? -22.61592 -18.82914 13.83545  1.000 31.18400  ? 134 PHE A N    1 
ATOM   1957 C CA   . PHE A 1 134 ? -22.49646 -20.24269 13.48707  1.000 30.57869  ? 134 PHE A CA   1 
ATOM   1958 C C    . PHE A 1 134 ? -21.30302 -20.55616 12.59426  1.000 30.76706  ? 134 PHE A C    1 
ATOM   1959 O O    . PHE A 1 134 ? -21.25782 -21.62752 11.97982  1.000 31.93216  ? 134 PHE A O    1 
ATOM   1960 C CB   . PHE A 1 134 ? -23.78577 -20.75810 12.83493  1.000 28.69153  ? 134 PHE A CB   1 
ATOM   1961 C CG   . PHE A 1 134 ? -24.94550 -20.86844 13.78726  1.000 28.91882  ? 134 PHE A CG   1 
ATOM   1962 C CD1  . PHE A 1 134 ? -25.03567 -21.93512 14.66956  1.000 29.49354  ? 134 PHE A CD1  1 
ATOM   1963 C CD2  . PHE A 1 134 ? -25.94465 -19.91226 13.79687  1.000 31.18754  ? 134 PHE A CD2  1 
ATOM   1964 C CE1  . PHE A 1 134 ? -26.10202 -22.04032 15.54579  1.000 32.32867  ? 134 PHE A CE1  1 
ATOM   1965 C CE2  . PHE A 1 134 ? -27.01235 -20.01154 14.66998  1.000 30.07189  ? 134 PHE A CE2  1 
ATOM   1966 C CZ   . PHE A 1 134 ? -27.09021 -21.07691 15.54469  1.000 31.87016  ? 134 PHE A CZ   1 
ATOM   1967 H H    . PHE A 1 134 ? -22.46695 -18.68928 14.67082  1.000 38.15687  ? 134 PHE A H    1 
ATOM   1968 H HA   . PHE A 1 134 ? -22.35106 -20.73096 14.31251  1.000 37.43050  ? 134 PHE A HA   1 
ATOM   1969 H HB2  . PHE A 1 134 ? -24.04210 -20.14773 12.12595  1.000 35.16590  ? 134 PHE A HB2  1 
ATOM   1970 H HB3  . PHE A 1 134 ? -23.61865 -21.64060 12.46865  1.000 35.16590  ? 134 PHE A HB3  1 
ATOM   1971 H HD1  . PHE A 1 134 ? -24.37223 -22.58684 14.67237  1.000 36.12832  ? 134 PHE A HD1  1 
ATOM   1972 H HD2  . PHE A 1 134 ? -25.89787 -19.19341 13.20868  1.000 38.16111  ? 134 PHE A HD2  1 
ATOM   1973 H HE1  . PHE A 1 134 ? -26.15248 -22.75881 16.13412  1.000 39.53047  ? 134 PHE A HE1  1 
ATOM   1974 H HE2  . PHE A 1 134 ? -27.67729 -19.36136 14.66799  1.000 36.82234  ? 134 PHE A HE2  1 
ATOM   1975 H HZ   . PHE A 1 134 ? -27.80769 -21.14524 16.13243  1.000 38.98026  ? 134 PHE A HZ   1 
ATOM   1976 N N    . THR A 1 135 ? -20.33131 -19.65342 12.51516  1.000 31.18870  ? 135 THR A N    1 
ATOM   1977 C CA   . THR A 1 135 ? -19.03104 -19.94660 11.93128  1.000 31.58117  ? 135 THR A CA   1 
ATOM   1978 C C    . THR A 1 135 ? -18.05483 -20.33606 13.03853  1.000 30.16758  ? 135 THR A C    1 
ATOM   1979 O O    . THR A 1 135 ? -18.34999 -20.22649 14.22948  1.000 32.00387  ? 135 THR A O    1 
ATOM   1980 C CB   . THR A 1 135 ? -18.46562 -18.74368 11.16649  1.000 32.02980  ? 135 THR A CB   1 
ATOM   1981 O OG1  . THR A 1 135 ? -18.30718 -17.63933 12.06353  1.000 33.92087  ? 135 THR A OG1  1 
ATOM   1982 C CG2  . THR A 1 135 ? -19.37346 -18.35362 10.01528  1.000 34.08174  ? 135 THR A CG2  1 
ATOM   1983 H H    . THR A 1 135 ? -20.40471 -18.84535 12.80017  1.000 38.16251  ? 135 THR A H    1 
ATOM   1984 H HA   . THR A 1 135 ? -19.13521 -20.67686 11.30138  1.000 38.63347  ? 135 THR A HA   1 
ATOM   1985 H HB   . THR A 1 135 ? -17.60224 -18.97650 10.79062  1.000 39.17183  ? 135 THR A HB   1 
ATOM   1986 H HG1  . THR A 1 135 ? -19.04539 -17.44634 12.41482  1.000 41.44111  ? 135 THR A HG1  1 
ATOM   1987 H HG21 . THR A 1 135 ? -18.94365 -17.67778 9.46811   1.000 41.63415  ? 135 THR A HG21 1 
ATOM   1988 H HG22 . THR A 1 135 ? -19.56387 -19.12962 9.46530   1.000 41.63415  ? 135 THR A HG22 1 
ATOM   1989 H HG23 . THR A 1 135 ? -20.20846 -17.99757 10.35719  1.000 41.63415  ? 135 THR A HG23 1 
ATOM   1990 N N    . ILE A 1 136 ? -16.86565 -20.77012 12.63428  1.000 30.89895  ? 136 ILE A N    1 
ATOM   1991 C CA   . ILE A 1 136 ? -15.76218 -20.95654 13.56640  1.000 33.30236  ? 136 ILE A CA   1 
ATOM   1992 C C    . ILE A 1 136 ? -14.49812 -20.39362 12.93275  1.000 33.64573  ? 136 ILE A C    1 
ATOM   1993 O O    . ILE A 1 136 ? -14.32813 -20.41580 11.71009  1.000 33.40669  ? 136 ILE A O    1 
ATOM   1994 C CB   . ILE A 1 136 ? -15.56878 -22.43138 13.97367  1.000 34.28567  ? 136 ILE A CB   1 
ATOM   1995 C CG1  . ILE A 1 136 ? -15.10710 -23.28453 12.80039  1.000 32.19934  ? 136 ILE A CG1  1 
ATOM   1996 C CG2  . ILE A 1 136 ? -16.86848 -22.99416 14.55079  1.000 32.36007  ? 136 ILE A CG2  1 
ATOM   1997 C CD1  . ILE A 1 136 ? -14.81007 -24.72444 13.19135  1.000 30.96513  ? 136 ILE A CD1  1 
ATOM   1998 H H    . ILE A 1 136 ? -16.67332 -20.96444 11.81890  1.000 37.81481  ? 136 ILE A H    1 
ATOM   1999 H HA   . ILE A 1 136 ? -15.94757 -20.45753 14.37727  1.000 40.69891  ? 136 ILE A HA   1 
ATOM   2000 H HB   . ILE A 1 136 ? -14.87474 -22.45733 14.65083  1.000 41.87888  ? 136 ILE A HB   1 
ATOM   2001 H HG12 . ILE A 1 136 ? -15.80411 -23.29549 12.12589  1.000 39.37527  ? 136 ILE A HG12 1 
ATOM   2002 H HG13 . ILE A 1 136 ? -14.29557 -22.90102 12.43265  1.000 39.37527  ? 136 ILE A HG13 1 
ATOM   2003 H HG21 . ILE A 1 136 ? -16.66364 -23.77725 15.08532  1.000 39.56816  ? 136 ILE A HG21 1 
ATOM   2004 H HG22 . ILE A 1 136 ? -17.28788 -22.31660 15.10389  1.000 39.56816  ? 136 ILE A HG22 1 
ATOM   2005 H HG23 . ILE A 1 136 ? -17.45902 -23.23726 13.82069  1.000 39.56816  ? 136 ILE A HG23 1 
ATOM   2006 H HD11 . ILE A 1 136 ? -14.42948 -25.18677 12.42826  1.000 37.89422  ? 136 ILE A HD11 1 
ATOM   2007 H HD12 . ILE A 1 136 ? -14.17950 -24.72789 13.92841  1.000 37.89422  ? 136 ILE A HD12 1 
ATOM   2008 H HD13 . ILE A 1 136 ? -15.63626 -25.15535 13.46084  1.000 37.89422  ? 136 ILE A HD13 1 
ATOM   2009 N N    . LYS A 1 137 ? -13.61629 -19.86861 13.77733  1.000 36.24575  ? 137 LYS A N    1 
ATOM   2010 C CA   . LYS A 1 137 ? -12.33861 -19.30949 13.34052  1.000 41.38212  ? 137 LYS A CA   1 
ATOM   2011 C C    . LYS A 1 137 ? -11.28660 -20.37211 13.64145  1.000 41.34386  ? 137 LYS A C    1 
ATOM   2012 O O    . LYS A 1 137 ? -10.70923 -20.41446 14.72865  1.000 42.10571  ? 137 LYS A O    1 
ATOM   2013 C CB   . LYS A 1 137 ? -12.05568 -17.98616 14.03742  1.000 44.67481  ? 137 LYS A CB   1 
ATOM   2014 C CG   . LYS A 1 137 ? -13.23085 -17.01327 13.99269  1.000 46.03119  ? 137 LYS A CG   1 
ATOM   2015 C CD   . LYS A 1 137 ? -12.79662 -15.55893 14.14170  1.000 56.90852  ? 137 LYS A CD   1 
ATOM   2016 C CE   . LYS A 1 137 ? -12.85456 -14.82179 12.80630  1.000 73.84927  ? 137 LYS A CE   1 
ATOM   2017 N NZ   . LYS A 1 137 ? -13.02485 -13.34905 12.98244  1.000 81.84876  ? 137 LYS A NZ   1 
ATOM   2018 H H    . LYS A 1 137 ? -13.73715 -19.82332 14.62759  1.000 44.23096  ? 137 LYS A H    1 
ATOM   2019 H HA   . LYS A 1 137 ? -12.34869 -19.13438 12.38651  1.000 50.39462  ? 137 LYS A HA   1 
ATOM   2020 H HB2  . LYS A 1 137 ? -11.84927 -18.16079 14.96898  1.000 54.34584  ? 137 LYS A HB2  1 
ATOM   2021 H HB3  . LYS A 1 137 ? -11.29969 -17.55967 13.60442  1.000 54.34584  ? 137 LYS A HB3  1 
ATOM   2022 H HG2  . LYS A 1 137 ? -13.68544 -17.10464 13.14070  1.000 55.97350  ? 137 LYS A HG2  1 
ATOM   2023 H HG3  . LYS A 1 137 ? -13.84086 -17.21984 14.71804  1.000 55.97350  ? 137 LYS A HG3  1 
ATOM   2024 H HD2  . LYS A 1 137 ? -13.38800 -15.10873 14.76500  1.000 69.02629  ? 137 LYS A HD2  1 
ATOM   2025 H HD3  . LYS A 1 137 ? -11.88392 -15.52744 14.46862  1.000 69.02629  ? 137 LYS A HD3  1 
ATOM   2026 H HE2  . LYS A 1 137 ? -12.02814 -14.97464 12.32197  1.000 89.35519  ? 137 LYS A HE2  1 
ATOM   2027 H HE3  . LYS A 1 137 ? -13.60690 -15.15356 12.29170  1.000 89.35519  ? 137 LYS A HE3  1 
ATOM   2028 H HZ1  . LYS A 1 137 ? -13.00845 -12.94382 12.19021  1.000 98.95458  ? 137 LYS A HZ1  1 
ATOM   2029 H HZ2  . LYS A 1 137 ? -13.80331 -13.17784 13.37839  1.000 98.95458  ? 137 LYS A HZ2  1 
ATOM   2030 H HZ3  . LYS A 1 137 ? -12.36693 -13.02468 13.48645  1.000 98.95458  ? 137 LYS A HZ3  1 
ATOM   2031 N N    . GLY A 1 138 ? -11.05486 -21.25522 12.66782  1.000 39.60587  ? 138 GLY A N    1 
ATOM   2032 C CA   . GLY A 1 138 ? -10.15228 -22.36384 12.82215  1.000 39.06980  ? 138 GLY A CA   1 
ATOM   2033 C C    . GLY A 1 138 ? -8.90669  -22.23481 11.97126  1.000 39.87836  ? 138 GLY A C    1 
ATOM   2034 O O    . GLY A 1 138 ? -8.51389  -21.13983 11.54794  1.000 42.42912  ? 138 GLY A O    1 
ATOM   2035 H H    . GLY A 1 138 ? -11.42557 -21.22032 11.89261  1.000 48.26312  ? 138 GLY A H    1 
ATOM   2036 H HA2  . GLY A 1 138 ? -9.87986  -22.42604 13.75103  1.000 47.61982  ? 138 GLY A HA2  1 
ATOM   2037 H HA3  . GLY A 1 138 ? -10.60754 -23.18273 12.57105  1.000 47.61982  ? 138 GLY A HA3  1 
ATOM   2038 N N    . SER A 1 139 ? -8.26313  -23.37708 11.72952  1.000 41.11313  ? 139 SER A N    1 
ATOM   2039 C CA   . SER A 1 139 ? -7.08738  -23.46586 10.86134  1.000 40.28196  ? 139 SER A CA   1 
ATOM   2040 C C    . SER A 1 139 ? -7.28294  -24.69900 9.98362   1.000 42.55789  ? 139 SER A C    1 
ATOM   2041 O O    . SER A 1 139 ? -7.06077  -25.82717 10.43512  1.000 41.53040  ? 139 SER A O    1 
ATOM   2042 C CB   . SER A 1 139 ? -5.80029  -23.55597 11.67049  1.000 42.39737  ? 139 SER A CB   1 
ATOM   2043 O OG   . SER A 1 139 ? -4.69723  -23.87384 10.83756  1.000 44.11063  ? 139 SER A OG   1 
ATOM   2044 H H    . SER A 1 139 ? -8.49406  -24.13433 12.06543  1.000 50.07183  ? 139 SER A H    1 
ATOM   2045 H HA   . SER A 1 139 ? -7.03197  -22.67763 10.29874  1.000 49.07442  ? 139 SER A HA   1 
ATOM   2046 H HB2  . SER A 1 139 ? -5.63627  -22.70079 12.09788  1.000 51.61291  ? 139 SER A HB2  1 
ATOM   2047 H HB3  . SER A 1 139 ? -5.89813  -24.24910 12.34198  1.000 51.61291  ? 139 SER A HB3  1 
ATOM   2048 H HG   . SER A 1 139 ? -3.98971  -23.88656 11.29018  1.000 53.66882  ? 139 SER A HG   1 
ATOM   2049 N N    . PHE A 1 140 ? -7.70132  -24.48186 8.73663   1.000 42.93857  ? 140 PHE A N    1 
ATOM   2050 C CA   . PHE A 1 140 ? -8.02991  -25.57057 7.82634   1.000 46.20976  ? 140 PHE A CA   1 
ATOM   2051 C C    . PHE A 1 140 ? -7.40837  -25.32229 6.46114   1.000 49.18456  ? 140 PHE A C    1 
ATOM   2052 O O    . PHE A 1 140 ? -7.55915  -24.23519 5.89569   1.000 48.98201  ? 140 PHE A O    1 
ATOM   2053 C CB   . PHE A 1 140 ? -9.55297  -25.72987 7.66779   1.000 43.59631  ? 140 PHE A CB   1 
ATOM   2054 C CG   . PHE A 1 140 ? -10.26945 -26.07601 8.94025   1.000 45.48253  ? 140 PHE A CG   1 
ATOM   2055 C CD1  . PHE A 1 140 ? -10.17834 -27.34892 9.47633   1.000 43.15643  ? 140 PHE A CD1  1 
ATOM   2056 C CD2  . PHE A 1 140 ? -11.04847 -25.13376 9.59216   1.000 41.36793  ? 140 PHE A CD2  1 
ATOM   2057 C CE1  . PHE A 1 140 ? -10.83945 -27.67194 10.64547  1.000 39.48089  ? 140 PHE A CE1  1 
ATOM   2058 C CE2  . PHE A 1 140 ? -11.71352 -25.45383 10.76167  1.000 39.99416  ? 140 PHE A CE2  1 
ATOM   2059 C CZ   . PHE A 1 140 ? -11.60965 -26.72470 11.28779  1.000 37.27642  ? 140 PHE A CZ   1 
ATOM   2060 H H    . PHE A 1 140 ? -7.80313  -23.70003 8.39316   1.000 52.26235  ? 140 PHE A H    1 
ATOM   2061 H HA   . PHE A 1 140 ? -7.65746  -26.39057 8.18661   1.000 56.18778  ? 140 PHE A HA   1 
ATOM   2062 H HB2  . PHE A 1 140 ? -9.92022  -24.89359 7.34121   1.000 53.05165  ? 140 PHE A HB2  1 
ATOM   2063 H HB3  . PHE A 1 140 ? -9.72610  -26.43981 7.02990   1.000 53.05165  ? 140 PHE A HB3  1 
ATOM   2064 H HD1  . PHE A 1 140 ? -9.66621  -27.99402 9.04451   1.000 52.52378  ? 140 PHE A HD1  1 
ATOM   2065 H HD2  . PHE A 1 140 ? -11.12496 -24.27667 9.23940   1.000 50.37759  ? 140 PHE A HD2  1 
ATOM   2066 H HE1  . PHE A 1 140 ? -10.76525 -28.52859 10.99979  1.000 48.11314  ? 140 PHE A HE1  1 
ATOM   2067 H HE2  . PHE A 1 140 ? -12.23057 -24.81251 11.19325  1.000 48.72906  ? 140 PHE A HE2  1 
ATOM   2068 H HZ   . PHE A 1 140 ? -12.05755 -26.94232 12.07324  1.000 45.46777  ? 140 PHE A HZ   1 
ATOM   2069 N N    . LEU A 1 141 ? -6.72945  -26.33322 5.93232   1.000 52.19138  ? 141 LEU A N    1 
ATOM   2070 C CA   . LEU A 1 141 ? -6.18362  -26.31683 4.58506   1.000 55.93542  ? 141 LEU A CA   1 
ATOM   2071 C C    . LEU A 1 141 ? -6.99270  -27.26098 3.69670   1.000 58.17021  ? 141 LEU A C    1 
ATOM   2072 O O    . LEU A 1 141 ? -7.89561  -27.96608 4.15690   1.000 58.70301  ? 141 LEU A O    1 
ATOM   2073 C CB   . LEU A 1 141 ? -4.70881  -26.71515 4.59857   1.000 61.24704  ? 141 LEU A CB   1 
ATOM   2074 C CG   . LEU A 1 141 ? -3.75071  -25.80410 5.36095   1.000 57.42651  ? 141 LEU A CG   1 
ATOM   2075 C CD1  . LEU A 1 141 ? -2.38781  -26.48245 5.45940   1.000 62.27280  ? 141 LEU A CD1  1 
ATOM   2076 C CD2  . LEU A 1 141 ? -3.63214  -24.44700 4.69714   1.000 54.48933  ? 141 LEU A CD2  1 
ATOM   2077 H H    . LEU A 1 141 ? -6.56733  -27.06592 6.35239   1.000 63.36572  ? 141 LEU A H    1 
ATOM   2078 H HA   . LEU A 1 141 ? -6.25208  -25.41766 4.22769   1.000 67.85857  ? 141 LEU A HA   1 
ATOM   2079 H HB2  . LEU A 1 141 ? -4.64133  -27.59557 5.00007   1.000 74.23251  ? 141 LEU A HB2  1 
ATOM   2080 H HB3  . LEU A 1 141 ? -4.39951  -26.74498 3.67968   1.000 74.23251  ? 141 LEU A HB3  1 
ATOM   2081 H HG   . LEU A 1 141 ? -4.09418  -25.64923 6.25478   1.000 69.64788  ? 141 LEU A HG   1 
ATOM   2082 H HD11 . LEU A 1 141 ? -1.75612  -25.86530 5.86064   1.000 75.46343  ? 141 LEU A HD11 1 
ATOM   2083 H HD12 . LEU A 1 141 ? -2.46946  -27.27680 6.01008   1.000 75.46343  ? 141 LEU A HD12 1 
ATOM   2084 H HD13 . LEU A 1 141 ? -2.09145  -26.72653 4.56862   1.000 75.46343  ? 141 LEU A HD13 1 
ATOM   2085 H HD21 . LEU A 1 141 ? -2.95379  -23.92848 5.15744   1.000 66.12327  ? 141 LEU A HD21 1 
ATOM   2086 H HD22 . LEU A 1 141 ? -3.38057  -24.57056 3.76852   1.000 66.12327  ? 141 LEU A HD22 1 
ATOM   2087 H HD23 . LEU A 1 141 ? -4.48795  -23.99352 4.75046   1.000 66.12327  ? 141 LEU A HD23 1 
ATOM   2088 N N    . ASN A 1 142 ? -6.66028  -27.26858 2.40650   1.000 60.15473  ? 142 ASN A N    1 
ATOM   2089 C CA   . ASN A 1 142 ? -7.26277  -28.23025 1.49238   1.000 63.28059  ? 142 ASN A CA   1 
ATOM   2090 C C    . ASN A 1 142 ? -7.04109  -29.64167 2.02216   1.000 63.13624  ? 142 ASN A C    1 
ATOM   2091 O O    . ASN A 1 142 ? -5.91875  -30.01445 2.37883   1.000 64.32654  ? 142 ASN A O    1 
ATOM   2092 C CB   . ASN A 1 142 ? -6.66635  -28.08504 0.09570   1.000 63.67066  ? 142 ASN A CB   1 
ATOM   2093 H H    . ASN A 1 142 ? -6.09502  -26.73302 2.04146   1.000 72.92174  ? 142 ASN A H    1 
ATOM   2094 H HA   . ASN A 1 142 ? -8.21593  -28.06450 1.42232   1.000 76.67278  ? 142 ASN A HA   1 
ATOM   2095 N N    . GLY A 1 143 ? -8.11547  -30.42393 2.09070   1.000 59.90754  ? 143 GLY A N    1 
ATOM   2096 C CA   . GLY A 1 143 ? -8.04230  -31.77854 2.58497   1.000 55.78578  ? 143 GLY A CA   1 
ATOM   2097 C C    . GLY A 1 143 ? -8.26910  -31.93740 4.07210   1.000 50.29303  ? 143 GLY A C    1 
ATOM   2098 O O    . GLY A 1 143 ? -8.33308  -33.07766 4.55370   1.000 45.68878  ? 143 GLY A O    1 
ATOM   2099 H H    . GLY A 1 143 ? -8.90529  -30.18191 1.85151   1.000 72.62512  ? 143 GLY A H    1 
ATOM   2100 H HA2  . GLY A 1 143 ? -8.71153  -32.31088 2.12711   1.000 67.67900  ? 143 GLY A HA2  1 
ATOM   2101 H HA3  . GLY A 1 143 ? -7.16293  -32.13417 2.38217   1.000 67.67900  ? 143 GLY A HA3  1 
ATOM   2102 N N    . SER A 1 144 ? -8.38057  -30.84051 4.81951   1.000 46.56563  ? 144 SER A N    1 
ATOM   2103 C CA   . SER A 1 144 ? -8.73919  -30.92782 6.22816   1.000 45.94976  ? 144 SER A CA   1 
ATOM   2104 C C    . SER A 1 144 ? -10.22698 -31.17668 6.43701   1.000 42.51278  ? 144 SER A C    1 
ATOM   2105 O O    . SER A 1 144 ? -10.64587 -31.40297 7.57820   1.000 38.33779  ? 144 SER A O    1 
ATOM   2106 C CB   . SER A 1 144 ? -8.33005  -29.64801 6.95610   1.000 45.11795  ? 144 SER A CB   1 
ATOM   2107 O OG   . SER A 1 144 ? -9.04780  -28.53927 6.45252   1.000 48.85912  ? 144 SER A OG   1 
ATOM   2108 H H    . SER A 1 144 ? -8.25374  -30.03945 4.53347   1.000 56.61482  ? 144 SER A H    1 
ATOM   2109 H HA   . SER A 1 144 ? -8.25111  -31.66407 6.62893   1.000 55.87577  ? 144 SER A HA   1 
ATOM   2110 H HB2  . SER A 1 144 ? -8.52156  -29.74640 7.90191   1.000 54.87760  ? 144 SER A HB2  1 
ATOM   2111 H HB3  . SER A 1 144 ? -7.38096  -29.49775 6.82367   1.000 54.87760  ? 144 SER A HB3  1 
ATOM   2112 H HG   . SER A 1 144 ? -9.01220  -28.53110 5.61332   1.000 59.36701  ? 144 SER A HG   1 
ATOM   2113 N N    . CYS A 1 145 ? -11.02907 -31.13333 5.37262   1.000 41.74689  ? 145 CYS A N    1 
ATOM   2114 C CA   . CYS A 1 145 ? -12.44462 -31.45599 5.48888   1.000 37.98629  ? 145 CYS A CA   1 
ATOM   2115 C C    . CYS A 1 145 ? -12.61541 -32.83149 6.11911   1.000 36.21155  ? 145 CYS A C    1 
ATOM   2116 O O    . CYS A 1 145 ? -11.82637 -33.74834 5.87579   1.000 37.40506  ? 145 CYS A O    1 
ATOM   2117 C CB   . CYS A 1 145 ? -13.11715 -31.42087 4.11712   1.000 37.52900  ? 145 CYS A CB   1 
ATOM   2118 S SG   . CYS A 1 145 ? -13.31436 -29.76184 3.44538   1.000 41.18837  ? 145 CYS A SG   1 
ATOM   2119 H H    . CYS A 1 145 ? -10.77723 -30.92108 4.57819   1.000 50.83233  ? 145 CYS A H    1 
ATOM   2120 H HA   . CYS A 1 145 ? -12.88093 -30.79609 6.05020   1.000 46.31961  ? 145 CYS A HA   1 
ATOM   2121 H HB2  . CYS A 1 145 ? -12.57765 -31.93070 3.49269   1.000 45.77087  ? 145 CYS A HB2  1 
ATOM   2122 H HB3  . CYS A 1 145 ? -13.99967 -31.81625 4.19280   1.000 45.77087  ? 145 CYS A HB3  1 
ATOM   2123 N N    . GLY A 1 146 ? -13.65588 -32.97188 6.93359   1.000 33.55840  ? 146 GLY A N    1 
ATOM   2124 C CA   . GLY A 1 146 ? -13.87144 -34.17278 7.69910   1.000 34.74401  ? 146 GLY A CA   1 
ATOM   2125 C C    . GLY A 1 146 ? -13.27104 -34.15409 9.08657   1.000 29.60886  ? 146 GLY A C    1 
ATOM   2126 O O    . GLY A 1 146 ? -13.62292 -35.00854 9.90551   1.000 33.19265  ? 146 GLY A O    1 
ATOM   2127 H H    . GLY A 1 146 ? -14.25690 -32.36902 7.05574   1.000 41.00615  ? 146 GLY A H    1 
ATOM   2128 H HA2  . GLY A 1 146 ? -14.82639 -34.31590 7.79124   1.000 42.42888  ? 146 GLY A HA2  1 
ATOM   2129 H HA3  . GLY A 1 146 ? -13.48477 -34.92160 7.21884   1.000 42.42888  ? 146 GLY A HA3  1 
ATOM   2130 N N    . SER A 1 147 ? -12.36436 -33.21754 9.36809   1.000 30.39148  ? 147 SER A N    1 
ATOM   2131 C CA   . SER A 1 147 ? -11.89458 -33.01328 10.73191  1.000 28.47713  ? 147 SER A CA   1 
ATOM   2132 C C    . SER A 1 147 ? -13.07976 -32.67242 11.62671  1.000 28.86381  ? 147 SER A C    1 
ATOM   2133 O O    . SER A 1 147 ? -14.00793 -31.97344 11.20848  1.000 25.33840  ? 147 SER A O    1 
ATOM   2134 C CB   . SER A 1 147 ? -10.85769 -31.88908 10.78003  1.000 31.12986  ? 147 SER A CB   1 
ATOM   2135 O OG   . SER A 1 147 ? -9.72880  -32.17429 9.97411   1.000 34.20343  ? 147 SER A OG   1 
ATOM   2136 H H    . SER A 1 147 ? -12.00870 -32.69099 8.78856   1.000 37.20584  ? 147 SER A H    1 
ATOM   2137 H HA   . SER A 1 147 ? -11.46738 -33.82021 11.05942  1.000 34.90863  ? 147 SER A HA   1 
ATOM   2138 H HB2  . SER A 1 147 ? -11.27002 -31.07152 10.45990  1.000 38.09189  ? 147 SER A HB2  1 
ATOM   2139 H HB3  . SER A 1 147 ? -10.56428 -31.77543 11.69758  1.000 38.09189  ? 147 SER A HB3  1 
ATOM   2140 H HG   . SER A 1 147 ? -9.93749  -32.13083 9.16161   1.000 41.78018  ? 147 SER A HG   1 
ATOM   2141 N N    . VAL A 1 148 ? -13.04423 -33.15444 12.86704  1.000 27.08333  ? 148 VAL A N    1 
ATOM   2142 C CA   . VAL A 1 148 ? -14.20746 -33.08562 13.74160  1.000 25.84979  ? 148 VAL A CA   1 
ATOM   2143 C C    . VAL A 1 148 ? -13.87787 -32.30373 15.00439  1.000 25.36708  ? 148 VAL A C    1 
ATOM   2144 O O    . VAL A 1 148 ? -12.72738 -32.24055 15.44952  1.000 26.67377  ? 148 VAL A O    1 
ATOM   2145 C CB   . VAL A 1 148 ? -14.73493 -34.49351 14.10950  1.000 25.40021  ? 148 VAL A CB   1 
ATOM   2146 C CG1  . VAL A 1 148 ? -15.16483 -35.23671 12.86027  1.000 28.19369  ? 148 VAL A CG1  1 
ATOM   2147 C CG2  . VAL A 1 148 ? -13.68082 -35.28064 14.87356  1.000 25.89271  ? 148 VAL A CG2  1 
ATOM   2148 H H    . VAL A 1 148 ? -12.35540 -33.52625 13.22322  1.000 33.23607  ? 148 VAL A H    1 
ATOM   2149 H HA   . VAL A 1 148 ? -14.90195 -32.59804 13.27166  1.000 31.75581  ? 148 VAL A HA   1 
ATOM   2150 H HB   . VAL A 1 148 ? -15.50876 -34.39902 14.68670  1.000 31.21632  ? 148 VAL A HB   1 
ATOM   2151 H HG11 . VAL A 1 148 ? -15.56405 -36.08246 13.11762  1.000 34.56850  ? 148 VAL A HG11 1 
ATOM   2152 H HG12 . VAL A 1 148 ? -15.81246 -34.69795 12.37942  1.000 34.56850  ? 148 VAL A HG12 1 
ATOM   2153 H HG13 . VAL A 1 148 ? -14.38667 -35.39422 12.30299  1.000 34.56850  ? 148 VAL A HG13 1 
ATOM   2154 H HG21 . VAL A 1 148 ? -14.01451 -36.17604 15.04029  1.000 31.80732  ? 148 VAL A HG21 1 
ATOM   2155 H HG22 . VAL A 1 148 ? -12.87102 -35.32322 14.34128  1.000 31.80732  ? 148 VAL A HG22 1 
ATOM   2156 H HG23 . VAL A 1 148 ? -13.50048 -34.83284 15.71490  1.000 31.80732  ? 148 VAL A HG23 1 
ATOM   2157 N N    . GLY A 1 149 ? -14.91503 -31.69699 15.57523  1.000 26.54781  ? 149 GLY A N    1 
ATOM   2158 C CA   . GLY A 1 149 ? -14.82542 -31.01385 16.85130  1.000 24.41097  ? 149 GLY A CA   1 
ATOM   2159 C C    . GLY A 1 149 ? -15.56625 -31.82616 17.89355  1.000 24.61984  ? 149 GLY A C    1 
ATOM   2160 O O    . GLY A 1 149 ? -16.53340 -32.52484 17.58038  1.000 22.97384  ? 149 GLY A O    1 
ATOM   2161 H H    . GLY A 1 149 ? -15.70163 -31.66944 15.22866  1.000 32.59344  ? 149 GLY A H    1 
ATOM   2162 H HA2  . GLY A 1 149 ? -13.89727 -30.92129 17.11751  1.000 30.02923  ? 149 GLY A HA2  1 
ATOM   2163 H HA3  . GLY A 1 149 ? -15.22533 -30.13236 16.78841  1.000 30.02923  ? 149 GLY A HA3  1 
ATOM   2164 N N    . PHE A 1 150 ? -15.10791 -31.74007 19.13752  1.000 25.25239  ? 150 PHE A N    1 
ATOM   2165 C CA   . PHE A 1 150 ? -15.64315 -32.61842 20.16191  1.000 25.40040  ? 150 PHE A CA   1 
ATOM   2166 C C    . PHE A 1 150 ? -15.38854 -32.03451 21.54217  1.000 26.25860  ? 150 PHE A C    1 
ATOM   2167 O O    . PHE A 1 150 ? -14.50992 -31.18927 21.73440  1.000 24.17355  ? 150 PHE A O    1 
ATOM   2168 C CB   . PHE A 1 150 ? -15.00501 -34.00998 20.07650  1.000 24.61244  ? 150 PHE A CB   1 
ATOM   2169 C CG   . PHE A 1 150 ? -13.52871 -33.99835 20.34380  1.000 25.82673  ? 150 PHE A CG   1 
ATOM   2170 C CD1  . PHE A 1 150 ? -12.63351 -33.70722 19.32673  1.000 25.17805  ? 150 PHE A CD1  1 
ATOM   2171 C CD2  . PHE A 1 150 ? -13.03258 -34.26362 21.61373  1.000 25.53232  ? 150 PHE A CD2  1 
ATOM   2172 C CE1  . PHE A 1 150 ? -11.27031 -33.68920 19.56527  1.000 27.66559  ? 150 PHE A CE1  1 
ATOM   2173 C CE2  . PHE A 1 150 ? -11.67121 -34.24417 21.85837  1.000 26.66924  ? 150 PHE A CE2  1 
ATOM   2174 C CZ   . PHE A 1 150 ? -10.79020 -33.95540 20.83296  1.000 29.50017  ? 150 PHE A CZ   1 
ATOM   2175 H H    . PHE A 1 150 ? -14.50086 -31.19253 19.40451  1.000 31.03894  ? 150 PHE A H    1 
ATOM   2176 H HA   . PHE A 1 150 ? -16.60283 -32.68211 20.03598  1.000 31.21655  ? 150 PHE A HA   1 
ATOM   2177 H HB2  . PHE A 1 150 ? -15.42305 -34.58839 20.73345  1.000 30.27100  ? 150 PHE A HB2  1 
ATOM   2178 H HB3  . PHE A 1 150 ? -15.14442 -34.36557 19.18486  1.000 30.27100  ? 150 PHE A HB3  1 
ATOM   2179 H HD1  . PHE A 1 150 ? -12.95278 -33.52163 18.47319  1.000 30.94973  ? 150 PHE A HD1  1 
ATOM   2180 H HD2  . PHE A 1 150 ? -13.62188 -34.45634 22.30690  1.000 31.37485  ? 150 PHE A HD2  1 
ATOM   2181 H HE1  . PHE A 1 150 ? -10.67872 -33.49828 18.87355  1.000 33.93477  ? 150 PHE A HE1  1 
ATOM   2182 H HE2  . PHE A 1 150 ? -11.34900 -34.42519 22.71178  1.000 32.73915  ? 150 PHE A HE2  1 
ATOM   2183 H HZ   . PHE A 1 150 ? -9.87480  -33.94033 20.99645  1.000 36.13627  ? 150 PHE A HZ   1 
ATOM   2184 N N    . ASN A 1 151 ? -16.17470 -32.51291 22.50052  1.000 26.04906  ? 151 ASN A N    1 
ATOM   2185 C CA   . ASN A 1 151 ? -15.93099 -32.33649 23.92273  1.000 28.79635  ? 151 ASN A CA   1 
ATOM   2186 C C    . ASN A 1 151 ? -15.79401 -33.71248 24.56356  1.000 31.80642  ? 151 ASN A C    1 
ATOM   2187 O O    . ASN A 1 151 ? -16.29773 -34.71360 24.04849  1.000 30.24122  ? 151 ASN A O    1 
ATOM   2188 C CB   . ASN A 1 151 ? -17.06352 -31.55393 24.60354  1.000 30.80348  ? 151 ASN A CB   1 
ATOM   2189 C CG   . ASN A 1 151 ? -17.04198 -30.08166 24.25929  1.000 29.86810  ? 151 ASN A CG   1 
ATOM   2190 O OD1  . ASN A 1 151 ? -16.37719 -29.28451 24.92439  1.000 29.80390  ? 151 ASN A OD1  1 
ATOM   2191 N ND2  . ASN A 1 151 ? -17.78485 -29.70537 23.22503  1.000 29.24125  ? 151 ASN A ND2  1 
ATOM   2192 H H    . ASN A 1 151 ? -16.88913 -32.96449 22.34159  1.000 31.99494  ? 151 ASN A H    1 
ATOM   2193 H HA   . ASN A 1 151 ? -15.11164 -31.83511 24.05759  1.000 35.29169  ? 151 ASN A HA   1 
ATOM   2194 H HB2  . ASN A 1 151 ? -17.91608 -31.91710 24.31694  1.000 37.70024  ? 151 ASN A HB2  1 
ATOM   2195 H HB3  . ASN A 1 151 ? -16.97326 -31.63893 25.56559  1.000 37.70024  ? 151 ASN A HB3  1 
ATOM   2196 H HD21 . ASN A 1 151 ? -17.80635 -28.87861 22.98923  1.000 35.82556  ? 151 ASN A HD21 1 
ATOM   2197 H HD22 . ASN A 1 151 ? -18.24447 -30.28842 22.79098  1.000 35.82556  ? 151 ASN A HD22 1 
ATOM   2198 N N    . ILE A 1 152 ? -15.11334 -33.75752 25.70760  1.000 34.10142  ? 152 ILE A N    1 
ATOM   2199 C CA   . ILE A 1 152 ? -14.94642 -34.98492 26.47783  1.000 35.53531  ? 152 ILE A CA   1 
ATOM   2200 C C    . ILE A 1 152 ? -15.48568 -34.74371 27.88055  1.000 39.99522  ? 152 ILE A C    1 
ATOM   2201 O O    . ILE A 1 152 ? -15.06311 -33.79945 28.55836  1.000 39.91192  ? 152 ILE A O    1 
ATOM   2202 C CB   . ILE A 1 152 ? -13.47419 -35.43875 26.52901  1.000 34.63417  ? 152 ILE A CB   1 
ATOM   2203 C CG1  . ILE A 1 152 ? -12.91655 -35.58451 25.11009  1.000 35.88482  ? 152 ILE A CG1  1 
ATOM   2204 C CG2  . ILE A 1 152 ? -13.35036 -36.74970 27.29522  1.000 40.57356  ? 152 ILE A CG2  1 
ATOM   2205 C CD1  . ILE A 1 152 ? -11.54120 -36.23175 25.04174  1.000 35.36077  ? 152 ILE A CD1  1 
ATOM   2206 H H    . ILE A 1 152 ? -14.73172 -33.07402 26.06368  1.000 41.65777  ? 152 ILE A H    1 
ATOM   2207 H HA   . ILE A 1 152 ? -15.46575 -35.69219 26.06434  1.000 43.37844  ? 152 ILE A HA   1 
ATOM   2208 H HB   . ILE A 1 152 ? -12.95691 -34.76269 26.99405  1.000 42.29708  ? 152 ILE A HB   1 
ATOM   2209 H HG12 . ILE A 1 152 ? -13.52587 -36.13393 24.59264  1.000 43.79785  ? 152 ILE A HG12 1 
ATOM   2210 H HG13 . ILE A 1 152 ? -12.84625 -34.70246 24.71268  1.000 43.79785  ? 152 ILE A HG13 1 
ATOM   2211 H HG21 . ILE A 1 152 ? -12.41059 -36.95387 27.42192  1.000 49.42434  ? 152 ILE A HG21 1 
ATOM   2212 H HG22 . ILE A 1 152 ? -13.78722 -36.65483 28.15607  1.000 49.42434  ? 152 ILE A HG22 1 
ATOM   2213 H HG23 . ILE A 1 152 ? -13.77625 -37.45563 26.78417  1.000 49.42434  ? 152 ILE A HG23 1 
ATOM   2214 H HD11 . ILE A 1 152 ? -11.18245 -36.11742 24.14780  1.000 43.16899  ? 152 ILE A HD11 1 
ATOM   2215 H HD12 . ILE A 1 152 ? -10.95863 -35.80461 25.68909  1.000 43.16899  ? 152 ILE A HD12 1 
ATOM   2216 H HD13 . ILE A 1 152 ? -11.62616 -37.17624 25.24576  1.000 43.16899  ? 152 ILE A HD13 1 
ATOM   2217 N N    . ASP A 1 153 ? -16.40997 -35.60030 28.31325  1.000 44.38567  ? 153 ASP A N    1 
ATOM   2218 C CA   . ASP A 1 153 ? -16.99154 -35.54915 29.65411  1.000 49.87864  ? 153 ASP A CA   1 
ATOM   2219 C C    . ASP A 1 153 ? -16.67702 -36.87221 30.34787  1.000 53.04231  ? 153 ASP A C    1 
ATOM   2220 O O    . ASP A 1 153 ? -17.36794 -37.87440 30.13400  1.000 55.23218  ? 153 ASP A O    1 
ATOM   2221 C CB   . ASP A 1 153 ? -18.49562 -35.29585 29.59431  1.000 52.48496  ? 153 ASP A CB   1 
ATOM   2222 H H    . ASP A 1 153 ? -16.72572 -36.23988 27.83279  1.000 53.99887  ? 153 ASP A H    1 
ATOM   2223 H HA   . ASP A 1 153 ? -16.58090 -34.82788 30.15616  1.000 60.59044  ? 153 ASP A HA   1 
ATOM   2224 N N    . TYR A 1 154 ? -15.63181 -36.87248 31.17497  1.000 55.90134  ? 154 TYR A N    1 
ATOM   2225 C CA   . TYR A 1 154 ? -15.19496 -38.08041 31.86344  1.000 60.08047  ? 154 TYR A CA   1 
ATOM   2226 C C    . TYR A 1 154 ? -14.75580 -39.13973 30.85963  1.000 59.74754  ? 154 TYR A C    1 
ATOM   2227 O O    . TYR A 1 154 ? -13.60648 -39.13549 30.40625  1.000 59.39340  ? 154 TYR A O    1 
ATOM   2228 C CB   . TYR A 1 154 ? -16.31074 -38.62257 32.76068  1.000 61.21886  ? 154 TYR A CB   1 
ATOM   2229 H H    . TYR A 1 154 ? -15.15640 -36.17860 31.35422  1.000 67.81767  ? 154 TYR A H    1 
ATOM   2230 H HA   . TYR A 1 154 ? -14.43660 -37.86629 32.42907  1.000 72.83263  ? 154 TYR A HA   1 
ATOM   2231 N N    . ASP A 1 155 ? -15.66617 -40.04554 30.49961  1.000 58.52226  ? 155 ASP A N    1 
ATOM   2232 C CA   . ASP A 1 155 ? -15.33121 -41.16850 29.63393  1.000 65.51169  ? 155 ASP A CA   1 
ATOM   2233 C C    . ASP A 1 155 ? -15.84243 -41.01555 28.20772  1.000 53.47087  ? 155 ASP A C    1 
ATOM   2234 O O    . ASP A 1 155 ? -15.35987 -41.72282 27.31590  1.000 51.84565  ? 155 ASP A O    1 
ATOM   2235 C CB   . ASP A 1 155 ? -15.89173 -42.47421 30.22301  1.000 58.01809  ? 155 ASP A CB   1 
ATOM   2236 C CG   . ASP A 1 155 ? -17.39133 -42.40510 30.49319  1.000 57.91348  ? 155 ASP A CG   1 
ATOM   2237 O OD1  . ASP A 1 155 ? -17.97971 -41.30744 30.37330  1.000 59.13949  ? 155 ASP A OD1  1 
ATOM   2238 O OD2  . ASP A 1 155 ? -17.98210 -43.45438 30.82643  1.000 59.64613  ? 155 ASP A OD2  1 
ATOM   2239 H H    . ASP A 1 155 ? -16.48962 -40.02876 30.74708  1.000 70.96279  ? 155 ASP A H    1 
ATOM   2240 H HA   . ASP A 1 155 ? -14.36510 -41.24412 29.59139  1.000 79.35009  ? 155 ASP A HA   1 
ATOM   2241 H HB2  . ASP A 1 155 ? -15.73313 -43.19726 29.59617  1.000 70.35778  ? 155 ASP A HB2  1 
ATOM   2242 H HB3  . ASP A 1 155 ? -15.44402 -42.65944 31.06333  1.000 70.35778  ? 155 ASP A HB3  1 
ATOM   2243 N N    . CYS A 1 156 ? -16.77719 -40.10096 27.97204  1.000 50.61806  ? 156 CYS A N    1 
ATOM   2244 C CA   . CYS A 1 156 ? -17.53646 -40.04368 26.72979  1.000 47.36479  ? 156 CYS A CA   1 
ATOM   2245 C C    . CYS A 1 156 ? -17.03329 -38.90721 25.84957  1.000 41.98660  ? 156 CYS A C    1 
ATOM   2246 O O    . CYS A 1 156 ? -16.80489 -37.79377 26.33267  1.000 37.80990  ? 156 CYS A O    1 
ATOM   2247 C CB   . CYS A 1 156 ? -19.02191 -39.85552 27.04746  1.000 46.76857  ? 156 CYS A CB   1 
ATOM   2248 S SG   . CYS A 1 156 ? -20.14366 -40.00304 25.64836  1.000 44.72822  ? 156 CYS A SG   1 
ATOM   2249 H H    . CYS A 1 156 ? -16.99499 -39.48626 28.53267  1.000 61.47774  ? 156 CYS A H    1 
ATOM   2250 H HA   . CYS A 1 156 ? -17.41491 -40.86696 26.23145  1.000 57.57382  ? 156 CYS A HA   1 
ATOM   2251 H HB2  . CYS A 1 156 ? -19.28160 -40.52766 27.69684  1.000 56.85835  ? 156 CYS A HB2  1 
ATOM   2252 H HB3  . CYS A 1 156 ? -19.14304 -38.96871 27.42136  1.000 56.85835  ? 156 CYS A HB3  1 
ATOM   2253 H HG   . CYS A 1 156 ? -19.81630 -39.21916 24.80080  1.000 54.40994  ? 156 CYS A HG   1 
ATOM   2254 N N    . VAL A 1 157 ? -16.84678 -39.19831 24.56451  1.000 37.41951  ? 157 VAL A N    1 
ATOM   2255 C CA   . VAL A 1 157 ? -16.51620 -38.18122 23.57218  1.000 34.58052  ? 157 VAL A CA   1 
ATOM   2256 C C    . VAL A 1 157 ? -17.82188 -37.71714 22.94102  1.000 33.03856  ? 157 VAL A C    1 
ATOM   2257 O O    . VAL A 1 157 ? -18.54111 -38.51177 22.32629  1.000 32.91780  ? 157 VAL A O    1 
ATOM   2258 C CB   . VAL A 1 157 ? -15.55129 -38.72170 22.50535  1.000 33.15736  ? 157 VAL A CB   1 
ATOM   2259 C CG1  . VAL A 1 157 ? -15.25240 -37.64554 21.45262  1.000 32.80877  ? 157 VAL A CG1  1 
ATOM   2260 C CG2  . VAL A 1 157 ? -14.26743 -39.21376 23.14651  1.000 34.93680  ? 157 VAL A CG2  1 
ATOM   2261 H H    . VAL A 1 157 ? -16.90748 -39.99164 24.23809  1.000 45.63948  ? 157 VAL A H    1 
ATOM   2262 H HA   . VAL A 1 157 ? -16.08587 -37.42924 24.00834  1.000 42.23269  ? 157 VAL A HA   1 
ATOM   2263 H HB   . VAL A 1 157 ? -15.97131 -39.47273 22.05765  1.000 40.52490  ? 157 VAL A HB   1 
ATOM   2264 H HG11 . VAL A 1 157 ? -14.58871 -37.98604 20.83256  1.000 40.10659  ? 157 VAL A HG11 1 
ATOM   2265 H HG12 . VAL A 1 157 ? -16.07077 -37.43282 20.97731  1.000 40.10659  ? 157 VAL A HG12 1 
ATOM   2266 H HG13 . VAL A 1 157 ? -14.91324 -36.85349 21.89818  1.000 40.10659  ? 157 VAL A HG13 1 
ATOM   2267 H HG21 . VAL A 1 157 ? -13.57747 -39.27230 22.46723  1.000 42.66023  ? 157 VAL A HG21 1 
ATOM   2268 H HG22 . VAL A 1 157 ? -13.99930 -38.58776 23.83726  1.000 42.66023  ? 157 VAL A HG22 1 
ATOM   2269 H HG23 . VAL A 1 157 ? -14.42376 -40.08851 23.53544  1.000 42.66023  ? 157 VAL A HG23 1 
ATOM   2270 N N    . SER A 1 158 ? -18.13627 -36.43935 23.09780  1.000 31.37579  ? 158 SER A N    1 
ATOM   2271 C CA   . SER A 1 158 ? -19.33558 -35.85455 22.50598  1.000 29.54994  ? 158 SER A CA   1 
ATOM   2272 C C    . SER A 1 158 ? -18.90722 -35.14314 21.23012  1.000 29.09887  ? 158 SER A C    1 
ATOM   2273 O O    . SER A 1 158 ? -18.39666 -34.02258 21.27316  1.000 27.47827  ? 158 SER A O    1 
ATOM   2274 C CB   . SER A 1 158 ? -20.02854 -34.91097 23.48001  1.000 29.09075  ? 158 SER A CB   1 
ATOM   2275 O OG   . SER A 1 158 ? -20.83669 -35.64424 24.38040  1.000 33.79677  ? 158 SER A OG   1 
ATOM   2276 H H    . SER A 1 158 ? -17.66421 -35.88027 23.54967  1.000 38.38701  ? 158 SER A H    1 
ATOM   2277 H HA   . SER A 1 158 ? -19.96582 -36.55634 22.27973  1.000 36.19600  ? 158 SER A HA   1 
ATOM   2278 H HB2  . SER A 1 158 ? -19.35737 -34.42163 23.98098  1.000 35.64497  ? 158 SER A HB2  1 
ATOM   2279 H HB3  . SER A 1 158 ? -20.58667 -34.29333 22.98210  1.000 35.64497  ? 158 SER A HB3  1 
ATOM   2280 H HG   . SER A 1 158 ? -21.27389 -35.11811 24.86788  1.000 41.29220  ? 158 SER A HG   1 
ATOM   2281 N N    . PHE A 1 159 ? -19.09585 -35.81085 20.09650  1.000 27.96909  ? 159 PHE A N    1 
ATOM   2282 C CA   . PHE A 1 159 ? -18.80157 -35.20509 18.80606  1.000 27.00911  ? 159 PHE A CA   1 
ATOM   2283 C C    . PHE A 1 159 ? -19.87614 -34.18382 18.46243  1.000 27.91844  ? 159 PHE A C    1 
ATOM   2284 O O    . PHE A 1 159 ? -21.07093 -34.48951 18.51041  1.000 28.79041  ? 159 PHE A O    1 
ATOM   2285 C CB   . PHE A 1 159 ? -18.73152 -36.27603 17.71780  1.000 27.31367  ? 159 PHE A CB   1 
ATOM   2286 C CG   . PHE A 1 159 ? -17.59913 -37.24362 17.88692  1.000 24.92700  ? 159 PHE A CG   1 
ATOM   2287 C CD1  . PHE A 1 159 ? -16.31342 -36.89558 17.50729  1.000 24.66094  ? 159 PHE A CD1  1 
ATOM   2288 C CD2  . PHE A 1 159 ? -17.82059 -38.50905 18.40479  1.000 28.23968  ? 159 PHE A CD2  1 
ATOM   2289 C CE1  . PHE A 1 159 ? -15.26665 -37.78756 17.65271  1.000 25.24189  ? 159 PHE A CE1  1 
ATOM   2290 C CE2  . PHE A 1 159 ? -16.77739 -39.40493 18.55142  1.000 28.42223  ? 159 PHE A CE2  1 
ATOM   2291 C CZ   . PHE A 1 159 ? -15.50031 -39.04333 18.17486  1.000 26.87887  ? 159 PHE A CZ   1 
ATOM   2292 H H    . PHE A 1 159 ? -19.39344 -36.61628 20.04835  1.000 34.29898  ? 159 PHE A H    1 
ATOM   2293 H HA   . PHE A 1 159 ? -17.94161 -34.75813 18.84607  1.000 33.14700  ? 159 PHE A HA   1 
ATOM   2294 H HB2  . PHE A 1 159 ? -19.55775 -36.78410 17.72783  1.000 33.51247  ? 159 PHE A HB2  1 
ATOM   2295 H HB3  . PHE A 1 159 ? -18.62086 -35.83957 16.85864  1.000 33.51247  ? 159 PHE A HB3  1 
ATOM   2296 H HD1  . PHE A 1 159 ? -16.15214 -36.05207 17.15038  1.000 30.32919  ? 159 PHE A HD1  1 
ATOM   2297 H HD2  . PHE A 1 159 ? -18.68025 -38.75895 18.65665  1.000 34.62368  ? 159 PHE A HD2  1 
ATOM   2298 H HE1  . PHE A 1 159 ? -14.40646 -37.54143 17.39896  1.000 31.02634  ? 159 PHE A HE1  1 
ATOM   2299 H HE2  . PHE A 1 159 ? -16.93661 -40.25077 18.90370  1.000 34.84275  ? 159 PHE A HE2  1 
ATOM   2300 H HZ   . PHE A 1 159 ? -14.79797 -39.64502 18.27278  1.000 32.99071  ? 159 PHE A HZ   1 
ATOM   2301 N N    . CYS A 1 160 ? -19.45583 -32.97228 18.09984  1.000 25.86095  ? 160 CYS A N    1 
ATOM   2302 C CA   . CYS A 1 160 ? -20.40210 -31.90250 17.82568  1.000 26.26482  ? 160 CYS A CA   1 
ATOM   2303 C C    . CYS A 1 160 ? -20.19184 -31.19318 16.49903  1.000 26.57536  ? 160 CYS A C    1 
ATOM   2304 O O    . CYS A 1 160 ? -21.07304 -30.42785 16.09276  1.000 26.37897  ? 160 CYS A O    1 
ATOM   2305 C CB   . CYS A 1 160 ? -20.35582 -30.85120 18.94624  1.000 27.80591  ? 160 CYS A CB   1 
ATOM   2306 S SG   . CYS A 1 160 ? -18.73579 -30.06703 19.17166  1.000 22.44874  ? 160 CYS A SG   1 
ATOM   2307 H H    . CYS A 1 160 ? -18.63027 -32.74988 18.00715  1.000 31.76921  ? 160 CYS A H    1 
ATOM   2308 H HA   . CYS A 1 160 ? -21.29076 -32.29083 17.80604  1.000 32.25385  ? 160 CYS A HA   1 
ATOM   2309 H HB2  . CYS A 1 160 ? -20.99462 -30.15103 18.73989  1.000 34.10316  ? 160 CYS A HB2  1 
ATOM   2310 H HB3  . CYS A 1 160 ? -20.59301 -31.28060 19.78306  1.000 34.10316  ? 160 CYS A HB3  1 
ATOM   2311 H HG   . CYS A 1 160 ? -18.81887 -29.24069 20.03783  1.000 27.67455  ? 160 CYS A HG   1 
ATOM   2312 N N    . TYR A 1 161 ? -19.07404 -31.41207 15.81343  1.000 24.04962  ? 161 TYR A N    1 
ATOM   2313 C CA   . TYR A 1 161 ? -18.75389 -30.62521 14.63360  1.000 25.40182  ? 161 TYR A CA   1 
ATOM   2314 C C    . TYR A 1 161 ? -17.96463 -31.46097 13.64151  1.000 24.63758  ? 161 TYR A C    1 
ATOM   2315 O O    . TYR A 1 161 ? -17.10765 -32.25499 14.03314  1.000 21.15783  ? 161 TYR A O    1 
ATOM   2316 C CB   . TYR A 1 161 ? -17.95070 -29.37117 15.02127  1.000 24.33354  ? 161 TYR A CB   1 
ATOM   2317 C CG   . TYR A 1 161 ? -17.54967 -28.50604 13.84834  1.000 24.93173  ? 161 TYR A CG   1 
ATOM   2318 C CD1  . TYR A 1 161 ? -18.44474 -27.60160 13.29410  1.000 24.91767  ? 161 TYR A CD1  1 
ATOM   2319 C CD2  . TYR A 1 161 ? -16.28160 -28.59445 13.29621  1.000 26.04548  ? 161 TYR A CD2  1 
ATOM   2320 C CE1  . TYR A 1 161 ? -18.08734 -26.81312 12.22000  1.000 26.08296  ? 161 TYR A CE1  1 
ATOM   2321 C CE2  . TYR A 1 161 ? -15.91231 -27.80676 12.22001  1.000 25.15277  ? 161 TYR A CE2  1 
ATOM   2322 C CZ   . TYR A 1 161 ? -16.82211 -26.91943 11.68692  1.000 26.21292  ? 161 TYR A CZ   1 
ATOM   2323 O OH   . TYR A 1 161 ? -16.45724 -26.13659 10.61306  1.000 28.33254  ? 161 TYR A OH   1 
ATOM   2324 H H    . TYR A 1 161 ? -18.48836 -32.00938 16.01290  1.000 29.59561  ? 161 TYR A H    1 
ATOM   2325 H HA   . TYR A 1 161 ? -19.57696 -30.35877 14.19488  1.000 31.21825  ? 161 TYR A HA   1 
ATOM   2326 H HB2  . TYR A 1 161 ? -18.49116 -28.82823 15.61627  1.000 29.93632  ? 161 TYR A HB2  1 
ATOM   2327 H HB3  . TYR A 1 161 ? -17.13863 -29.65007 15.47254  1.000 29.93632  ? 161 TYR A HB3  1 
ATOM   2328 H HD1  . TYR A 1 161 ? -19.29947 -27.52586 13.65271  1.000 30.63727  ? 161 TYR A HD1  1 
ATOM   2329 H HD2  . TYR A 1 161 ? -15.66788 -29.19383 13.65535  1.000 31.99065  ? 161 TYR A HD2  1 
ATOM   2330 H HE1  . TYR A 1 161 ? -18.69802 -26.21259 11.85761  1.000 32.03562  ? 161 TYR A HE1  1 
ATOM   2331 H HE2  . TYR A 1 161 ? -15.05771 -27.87558 11.85969  1.000 30.91939  ? 161 TYR A HE2  1 
ATOM   2332 H HH   . TYR A 1 161 ? -15.65878 -26.29123 10.40294  1.000 34.73512  ? 161 TYR A HH   1 
ATOM   2333 N N    . MET A 1 162 ? -18.27241 -31.28460 12.35772  1.000 24.56976  ? 162 MET A N    1 
ATOM   2334 C CA   . MET A 1 162 ? -17.46424 -31.81475 11.26703  1.000 25.51299  ? 162 MET A CA   1 
ATOM   2335 C C    . MET A 1 162 ? -17.27106 -30.70420 10.24308  1.000 27.18521  ? 162 MET A C    1 
ATOM   2336 O O    . MET A 1 162 ? -18.24171 -30.06085 9.82957   1.000 25.59334  ? 162 MET A O    1 
ATOM   2337 C CB   . MET A 1 162 ? -18.10925 -33.03785 10.61380  1.000 26.48739  ? 162 MET A CB   1 
ATOM   2338 C CG   . MET A 1 162 ? -17.35471 -33.53098 9.38823   1.000 28.26367  ? 162 MET A CG   1 
ATOM   2339 S SD   . MET A 1 162 ? -17.99758 -35.05907 8.68960   1.000 29.92423  ? 162 MET A SD   1 
ATOM   2340 C CE   . MET A 1 162 ? -17.25127 -36.27098 9.77557   1.000 31.93110  ? 162 MET A CE   1 
ATOM   2341 H H    . MET A 1 162 ? -18.96355 -30.84928 12.08861  1.000 30.21979  ? 162 MET A H    1 
ATOM   2342 H HA   . MET A 1 162 ? -16.60430 -32.10132 11.61239  1.000 31.35165  ? 162 MET A HA   1 
ATOM   2343 H HB2  . MET A 1 162 ? -18.13531 -33.76136 11.25936  1.000 32.52094  ? 162 MET A HB2  1 
ATOM   2344 H HB3  . MET A 1 162 ? -19.00996 -32.80753 10.33708  1.000 32.52094  ? 162 MET A HB3  1 
ATOM   2345 H HG2  . MET A 1 162 ? -17.40324 -32.84996 8.69920   1.000 34.65247  ? 162 MET A HG2  1 
ATOM   2346 H HG3  . MET A 1 162 ? -16.42989 -33.68749 9.63544   1.000 34.65247  ? 162 MET A HG3  1 
ATOM   2347 H HE1  . MET A 1 162 ? -17.57626 -37.15281 9.53543   1.000 39.05338  ? 162 MET A HE1  1 
ATOM   2348 H HE2  . MET A 1 162 ? -16.28727 -36.23477 9.67412   1.000 39.05338  ? 162 MET A HE2  1 
ATOM   2349 H HE3  . MET A 1 162 ? -17.49535 -36.06671 10.69187  1.000 39.05338  ? 162 MET A HE3  1 
ATOM   2350 N N    . HIS A 1 163 ? -16.02467 -30.48712 9.83174   1.000 27.50686  ? 163 HIS A N    1 
ATOM   2351 C CA   . HIS A 1 163 ? -15.69284 -29.37330 8.95356   1.000 28.74185  ? 163 HIS A CA   1 
ATOM   2352 C C    . HIS A 1 163 ? -16.02799 -29.70683 7.50665   1.000 28.96799  ? 163 HIS A C    1 
ATOM   2353 O O    . HIS A 1 163 ? -15.67946 -30.78987 7.02304   1.000 30.11466  ? 163 HIS A O    1 
ATOM   2354 C CB   . HIS A 1 163 ? -14.21173 -29.02728 9.08564   1.000 30.80808  ? 163 HIS A CB   1 
ATOM   2355 C CG   . HIS A 1 163 ? -13.77610 -27.92043 8.17973   1.000 33.19426  ? 163 HIS A CG   1 
ATOM   2356 N ND1  . HIS A 1 163 ? -14.22135 -26.62652 8.32713   1.000 34.49376  ? 163 HIS A ND1  1 
ATOM   2357 C CD2  . HIS A 1 163 ? -12.95084 -27.91604 7.10617   1.000 37.67197  ? 163 HIS A CD2  1 
ATOM   2358 C CE1  . HIS A 1 163 ? -13.68502 -25.86789 7.38772   1.000 34.55829  ? 163 HIS A CE1  1 
ATOM   2359 N NE2  . HIS A 1 163 ? -12.90830 -26.62492 6.63622   1.000 36.44954  ? 163 HIS A NE2  1 
ATOM   2360 H H    . HIS A 1 163 ? -15.35017 -30.97430 10.04925  1.000 33.74430  ? 163 HIS A H    1 
ATOM   2361 H HA   . HIS A 1 163 ? -16.21906 -28.59945 9.20882   1.000 35.22628  ? 163 HIS A HA   1 
ATOM   2362 H HB2  . HIS A 1 163 ? -14.03492 -28.75131 9.99859   1.000 37.70577  ? 163 HIS A HB2  1 
ATOM   2363 H HB3  . HIS A 1 163 ? -13.68611 -29.81319 8.86892   1.000 37.70577  ? 163 HIS A HB3  1 
ATOM   2364 H HD2  . HIS A 1 163 ? -12.49841 -28.64805 6.75350   1.000 45.94243  ? 163 HIS A HD2  1 
ATOM   2365 H HE1  . HIS A 1 163 ? -13.83013 -24.95618 7.27535   1.000 42.20602  ? 163 HIS A HE1  1 
ATOM   2366 H HE2  . HIS A 1 163 ? -12.44938 -26.35418 5.96117   1.000 44.47552  ? 163 HIS A HE2  1 
ATOM   2367 N N    . HIS A 1 164 ? -16.67863 -28.77020 6.81289   1.000 29.63890  ? 164 HIS A N    1 
ATOM   2368 C CA   . HIS A 1 164 ? -17.03585 -28.96195 5.41494   1.000 29.97022  ? 164 HIS A CA   1 
ATOM   2369 C C    . HIS A 1 164 ? -16.43589 -27.91272 4.49022   1.000 33.30003  ? 164 HIS A C    1 
ATOM   2370 O O    . HIS A 1 164 ? -15.84240 -28.26940 3.46669   1.000 34.47183  ? 164 HIS A O    1 
ATOM   2371 C CB   . HIS A 1 164 ? -18.56428 -28.94855 5.23656   1.000 28.11239  ? 164 HIS A CB   1 
ATOM   2372 C CG   . HIS A 1 164 ? -19.25533 -30.18272 5.72042   1.000 29.46758  ? 164 HIS A CG   1 
ATOM   2373 N ND1  . HIS A 1 164 ? -19.96942 -31.01249 4.88123   1.000 27.14468  ? 164 HIS A ND1  1 
ATOM   2374 C CD2  . HIS A 1 164 ? -19.35733 -30.71876 6.95798   1.000 24.93049  ? 164 HIS A CD2  1 
ATOM   2375 C CE1  . HIS A 1 164 ? -20.47562 -32.01141 5.58174   1.000 28.69011  ? 164 HIS A CE1  1 
ATOM   2376 N NE2  . HIS A 1 164 ? -20.11995 -31.85549 6.84435   1.000 28.48740  ? 164 HIS A NE2  1 
ATOM   2377 H H    . HIS A 1 164 ? -16.92353 -28.01189 7.13630   1.000 36.30275  ? 164 HIS A H    1 
ATOM   2378 H HA   . HIS A 1 164 ? -16.69719 -29.83228 5.15277   1.000 36.70033  ? 164 HIS A HA   1 
ATOM   2379 H HB2  . HIS A 1 164 ? -18.92659 -28.19691 5.73119   1.000 34.47093  ? 164 HIS A HB2  1 
ATOM   2380 H HB3  . HIS A 1 164 ? -18.76441 -28.85182 4.29237   1.000 34.47093  ? 164 HIS A HB3  1 
ATOM   2381 H HD1  . HIS A 1 164 ? -20.06936 -30.89751 4.03483   1.000 33.30968  ? 164 HIS A HD1  1 
ATOM   2382 H HD2  . HIS A 1 164 ? -18.98178 -30.38120 7.73895   1.000 30.65266  ? 164 HIS A HD2  1 
ATOM   2383 H HE1  . HIS A 1 164 ? -20.99383 -32.70579 5.24380   1.000 35.16420  ? 164 HIS A HE1  1 
ATOM   2384 N N    . MET A 1 165 ? -16.59183 -26.62482 4.79986   1.000 31.57050  ? 165 MET A N    1 
ATOM   2385 C CA   . MET A 1 165 ? -16.31379 -25.57817 3.82904   1.000 36.72755  ? 165 MET A CA   1 
ATOM   2386 C C    . MET A 1 165 ? -15.46863 -24.46014 4.41898   1.000 35.56937  ? 165 MET A C    1 
ATOM   2387 O O    . MET A 1 165 ? -15.58062 -24.12767 5.60140   1.000 35.24524  ? 165 MET A O    1 
ATOM   2388 C CB   . MET A 1 165 ? -17.61683 -24.94527 3.28938   1.000 35.39214  ? 165 MET A CB   1 
ATOM   2389 C CG   . MET A 1 165 ? -18.70727 -25.93168 2.93267   1.000 35.72162  ? 165 MET A CG   1 
ATOM   2390 S SD   . MET A 1 165 ? -18.34145 -26.86373 1.43477   1.000 44.40986  ? 165 MET A SD   1 
ATOM   2391 C CE   . MET A 1 165 ? -18.51652 -25.60226 0.17192   1.000 43.56436  ? 165 MET A CE   1 
ATOM   2392 H H    . MET A 1 165 ? -16.85736 -26.33777 5.56583   1.000 38.62066  ? 165 MET A H    1 
ATOM   2393 H HA   . MET A 1 165 ? -15.81772 -25.99280 3.10592   1.000 44.80913  ? 165 MET A HA   1 
ATOM   2394 H HB2  . MET A 1 165 ? -17.97318 -24.35074 3.96794   1.000 43.20664  ? 165 MET A HB2  1 
ATOM   2395 H HB3  . MET A 1 165 ? -17.40479 -24.44345 2.48680   1.000 43.20664  ? 165 MET A HB3  1 
ATOM   2396 H HG2  . MET A 1 165 ? -18.81238 -26.56364 3.66100   1.000 43.60202  ? 165 MET A HG2  1 
ATOM   2397 H HG3  . MET A 1 165 ? -19.53627 -25.44856 2.79037   1.000 43.60202  ? 165 MET A HG3  1 
ATOM   2398 H HE1  . MET A 1 165 ? -19.29615 -25.80311 -0.36914  1.000 53.01330  ? 165 MET A HE1  1 
ATOM   2399 H HE2  . MET A 1 165 ? -18.62498 -24.73900 0.60077   1.000 53.01330  ? 165 MET A HE2  1 
ATOM   2400 H HE3  . MET A 1 165 ? -17.72091 -25.59833 -0.38296  1.000 53.01330  ? 165 MET A HE3  1 
ATOM   2401 N N    . VAL A 1 166 ? -14.62940 -23.87908 3.56536   1.000 37.54085  ? 166 VAL A N    1 
ATOM   2402 C CA   . VAL A 1 166 ? -14.02619 -22.57209 3.79820   1.000 41.62859  ? 166 VAL A CA   1 
ATOM   2403 C C    . VAL A 1 166 ? -14.77018 -21.57442 2.91838   1.000 44.80574  ? 166 VAL A C    1 
ATOM   2404 O O    . VAL A 1 166 ? -14.78228 -21.70966 1.68830   1.000 43.59075  ? 166 VAL A O    1 
ATOM   2405 C CB   . VAL A 1 166 ? -12.52274 -22.57151 3.48102   1.000 43.10111  ? 166 VAL A CB   1 
ATOM   2406 C CG1  . VAL A 1 166 ? -11.93124 -21.18910 3.72977   1.000 49.04823  ? 166 VAL A CG1  1 
ATOM   2407 C CG2  . VAL A 1 166 ? -11.79972 -23.62614 4.30661   1.000 41.91799  ? 166 VAL A CG2  1 
ATOM   2408 H H    . VAL A 1 166 ? -14.38727 -24.23498 2.82083   1.000 45.78509  ? 166 VAL A H    1 
ATOM   2409 H HA   . VAL A 1 166 ? -14.13274 -22.32323 4.72966   1.000 50.69038  ? 166 VAL A HA   1 
ATOM   2410 N N    . LEU A 1 167 ? -15.39928 -20.58122 3.53850   1.000 47.69304  ? 167 LEU A N    1 
ATOM   2411 C CA   . LEU A 1 167 ? -16.15632 -19.59144 2.79073   1.000 52.09235  ? 167 LEU A CA   1 
ATOM   2412 C C    . LEU A 1 167 ? -15.21708 -18.59518 2.11961   1.000 53.55128  ? 167 LEU A C    1 
ATOM   2413 O O    . LEU A 1 167 ? -14.06638 -18.43380 2.53525   1.000 52.60388  ? 167 LEU A O    1 
ATOM   2414 C CB   . LEU A 1 167 ? -17.11514 -18.85263 3.71573   1.000 58.58270  ? 167 LEU A CB   1 
ATOM   2415 C CG   . LEU A 1 167 ? -18.00061 -19.69608 4.63254   1.000 48.18729  ? 167 LEU A CG   1 
ATOM   2416 C CD1  . LEU A 1 167 ? -19.03307 -18.81082 5.32389   1.000 47.77848  ? 167 LEU A CD1  1 
ATOM   2417 C CD2  . LEU A 1 167 ? -18.67362 -20.81942 3.86427   1.000 45.44344  ? 167 LEU A CD2  1 
ATOM   2418 H H    . LEU A 1 167 ? -15.40151 -20.46091 4.39004   1.000 57.96772  ? 167 LEU A H    1 
ATOM   2419 H HA   . LEU A 1 167 ? -16.67812 -20.03528 2.10397   1.000 63.24689  ? 167 LEU A HA   1 
ATOM   2420 H HB2  . LEU A 1 167 ? -16.58790 -18.27428 4.28882   1.000 71.03530  ? 167 LEU A HB2  1 
ATOM   2421 H HB3  . LEU A 1 167 ? -17.70906 -18.32043 3.16353   1.000 71.03530  ? 167 LEU A HB3  1 
ATOM   2422 H HG   . LEU A 1 167 ? -17.44712 -20.10785 5.31444   1.000 58.56082  ? 167 LEU A HG   1 
ATOM   2423 H HD11 . LEU A 1 167 ? -19.31315 -19.23743 6.14879   1.000 58.07024  ? 167 LEU A HD11 1 
ATOM   2424 H HD12 . LEU A 1 167 ? -18.63165 -17.94912 5.51687   1.000 58.07024  ? 167 LEU A HD12 1 
ATOM   2425 H HD13 . LEU A 1 167 ? -19.79554 -18.69618 4.73534   1.000 58.07024  ? 167 LEU A HD13 1 
ATOM   2426 H HD21 . LEU A 1 167 ? -19.39648 -21.18028 4.40107   1.000 55.26819  ? 167 LEU A HD21 1 
ATOM   2427 H HD22 . LEU A 1 167 ? -19.02428 -20.46662 3.03152   1.000 55.26819  ? 167 LEU A HD22 1 
ATOM   2428 H HD23 . LEU A 1 167 ? -18.02008 -21.51232 3.68082   1.000 55.26819  ? 167 LEU A HD23 1 
ATOM   2429 N N    . PRO A 1 168 ? -15.68595 -17.90274 1.07080   1.000 55.19063  ? 168 PRO A N    1 
ATOM   2430 C CA   . PRO A 1 168 ? -14.86369 -16.84192 0.46599   1.000 54.68462  ? 168 PRO A CA   1 
ATOM   2431 C C    . PRO A 1 168 ? -14.38179 -15.84551 1.50788   1.000 56.60825  ? 168 PRO A C    1 
ATOM   2432 O O    . PRO A 1 168 ? -13.34883 -15.19181 1.33438   1.000 55.83681  ? 168 PRO A O    1 
ATOM   2433 C CB   . PRO A 1 168 ? -15.81160 -16.19186 -0.55011  1.000 54.51131  ? 168 PRO A CB   1 
ATOM   2434 C CG   . PRO A 1 168 ? -16.78822 -17.27535 -0.89830  1.000 55.86364  ? 168 PRO A CG   1 
ATOM   2435 C CD   . PRO A 1 168 ? -16.97221 -18.08278 0.36764   1.000 58.45296  ? 168 PRO A CD   1 
ATOM   2436 H HA   . PRO A 1 168 ? -14.10497 -17.21642 -0.00835  1.000 66.35761  ? 168 PRO A HA   1 
ATOM   2437 H HB2  . PRO A 1 168 ? -16.26138 -15.43301 -0.14668  1.000 66.14964  ? 168 PRO A HB2  1 
ATOM   2438 H HB3  . PRO A 1 168 ? -15.31451 -15.90547 -1.33227  1.000 66.14964  ? 168 PRO A HB3  1 
ATOM   2439 H HG2  . PRO A 1 168 ? -17.62847 -16.88110 -1.18017  1.000 67.77244  ? 168 PRO A HG2  1 
ATOM   2440 H HG3  . PRO A 1 168 ? -16.42585 -17.82731 -1.60888  1.000 67.77244  ? 168 PRO A HG3  1 
ATOM   2441 H HD2  . PRO A 1 168 ? -17.70705 -17.73431 0.89631   1.000 70.87962  ? 168 PRO A HD2  1 
ATOM   2442 H HD3  . PRO A 1 168 ? -17.12587 -19.01818 0.16191   1.000 70.87962  ? 168 PRO A HD3  1 
ATOM   2443 N N    . THR A 1 169 ? -15.13292 -15.74084 2.60579   1.000 59.68262  ? 169 THR A N    1 
ATOM   2444 C CA   . THR A 1 169 ? -14.79145 -14.81200 3.67444   1.000 61.26805  ? 169 THR A CA   1 
ATOM   2445 C C    . THR A 1 169 ? -13.55202 -15.23741 4.44994   1.000 58.31298  ? 169 THR A C    1 
ATOM   2446 O O    . THR A 1 169 ? -12.98770 -14.42049 5.18551   1.000 59.35082  ? 169 THR A O    1 
ATOM   2447 C CB   . THR A 1 169 ? -15.96572 -14.67997 4.65156   1.000 66.48094  ? 169 THR A CB   1 
ATOM   2448 O OG1  . THR A 1 169 ? -17.08523 -15.42644 4.15683   1.000 67.79213  ? 169 THR A OG1  1 
ATOM   2449 C CG2  . THR A 1 169 ? -16.36141 -13.22341 4.82790   1.000 65.73423  ? 169 THR A CG2  1 
ATOM   2450 H H    . THR A 1 169 ? -15.84590 -16.19843 2.75369   1.000 72.35521  ? 169 THR A H    1 
ATOM   2451 H HA   . THR A 1 169 ? -14.61741 -13.94569 3.27430   1.000 74.25773  ? 169 THR A HA   1 
ATOM   2452 H HB   . THR A 1 169 ? -15.70435 -15.02589 5.51928   1.000 80.51320  ? 169 THR A HB   1 
ATOM   2453 H HG1  . THR A 1 169 ? -17.56690 -15.67987 4.79664   1.000 82.08662  ? 169 THR A HG1  1 
ATOM   2454 H HG21 . THR A 1 169 ? -17.07902 -13.15075 5.47647   1.000 79.61714  ? 169 THR A HG21 1 
ATOM   2455 H HG22 . THR A 1 169 ? -15.60110 -12.70861 5.14066   1.000 79.61714  ? 169 THR A HG22 1 
ATOM   2456 H HG23 . THR A 1 169 ? -16.66325 -12.85689 3.98206   1.000 79.61714  ? 169 THR A HG23 1 
ATOM   2457 N N    . GLY A 1 170 ? -13.12341 -16.49044 4.31277   1.000 56.02934  ? 170 GLY A N    1 
ATOM   2458 C CA   . GLY A 1 170 ? -12.04823 -17.02505 5.11525   1.000 54.35003  ? 170 GLY A CA   1 
ATOM   2459 C C    . GLY A 1 170 ? -12.49216 -17.74549 6.36749   1.000 51.59310  ? 170 GLY A C    1 
ATOM   2460 O O    . GLY A 1 170 ? -11.67524 -18.44473 6.98209   1.000 49.93411  ? 170 GLY A O    1 
ATOM   2461 H H    . GLY A 1 170 ? -13.45012 -17.05299 3.75028   1.000 67.97128  ? 170 GLY A H    1 
ATOM   2462 H HA2  . GLY A 1 170 ? -11.54022 -17.65195 4.57690   1.000 65.95611  ? 170 GLY A HA2  1 
ATOM   2463 H HA3  . GLY A 1 170 ? -11.46747 -16.29570 5.38297   1.000 65.95611  ? 170 GLY A HA3  1 
ATOM   2464 N N    . VAL A 1 171 ? -13.75729 -17.60118 6.76284   1.000 51.44115  ? 171 VAL A N    1 
ATOM   2465 C CA   . VAL A 1 171 ? -14.29229 -18.28788 7.93124   1.000 49.00494  ? 171 VAL A CA   1 
ATOM   2466 C C    . VAL A 1 171 ? -14.66491 -19.71171 7.53849   1.000 43.93836  ? 171 VAL A C    1 
ATOM   2467 O O    . VAL A 1 171 ? -14.71568 -20.04874 6.34967   1.000 41.94106  ? 171 VAL A O    1 
ATOM   2468 C CB   . VAL A 1 171 ? -15.50755 -17.54419 8.51411   1.000 48.17010  ? 171 VAL A CB   1 
ATOM   2469 C CG1  . VAL A 1 171 ? -15.14193 -16.11158 8.86830   1.000 51.24351  ? 171 VAL A CG1  1 
ATOM   2470 C CG2  . VAL A 1 171 ? -16.67145 -17.58312 7.53101   1.000 59.11501  ? 171 VAL A CG2  1 
ATOM   2471 H H    . VAL A 1 171 ? -14.33244 -17.10251 6.36268   1.000 62.46545  ? 171 VAL A H    1 
ATOM   2472 H HA   . VAL A 1 171 ? -13.60667 -18.32379 8.61647   1.000 59.54200  ? 171 VAL A HA   1 
ATOM   2473 H HB   . VAL A 1 171 ? -15.78710 -17.98707 9.33057   1.000 58.54019  ? 171 VAL A HB   1 
ATOM   2474 H HG11 . VAL A 1 171 ? -15.77216 -15.77820 9.52600   1.000 62.22828  ? 171 VAL A HG11 1 
ATOM   2475 H HG12 . VAL A 1 171 ? -14.24345 -16.09604 9.23353   1.000 62.22828  ? 171 VAL A HG12 1 
ATOM   2476 H HG13 . VAL A 1 171 ? -15.18235 -15.56778 8.06608   1.000 62.22828  ? 171 VAL A HG13 1 
ATOM   2477 H HG21 . VAL A 1 171 ? -17.26791 -16.84145 7.71823   1.000 71.67408  ? 171 VAL A HG21 1 
ATOM   2478 H HG22 . VAL A 1 171 ? -16.32479 -17.50902 6.62810   1.000 71.67408  ? 171 VAL A HG22 1 
ATOM   2479 H HG23 . VAL A 1 171 ? -17.14517 -18.42310 7.63555   1.000 71.67408  ? 171 VAL A HG23 1 
ATOM   2480 N N    . HIS A 1 172 ? -14.94881 -20.54861 8.53122   1.000 39.27156  ? 172 HIS A N    1 
ATOM   2481 C CA   . HIS A 1 172 ? -15.17365 -21.97036 8.32287   1.000 35.12098  ? 172 HIS A CA   1 
ATOM   2482 C C    . HIS A 1 172 ? -16.57553 -22.35729 8.76285   1.000 34.12953  ? 172 HIS A C    1 
ATOM   2483 O O    . HIS A 1 172 ? -17.10070 -21.83170 9.74821   1.000 32.43991  ? 172 HIS A O    1 
ATOM   2484 C CB   . HIS A 1 172 ? -14.12320 -22.78481 9.07990   1.000 35.24633  ? 172 HIS A CB   1 
ATOM   2485 C CG   . HIS A 1 172 ? -12.71882 -22.40305 8.73791   1.000 40.46775  ? 172 HIS A CG   1 
ATOM   2486 N ND1  . HIS A 1 172 ? -11.89521 -21.71951 9.60771   1.000 41.86762  ? 172 HIS A ND1  1 
ATOM   2487 C CD2  . HIS A 1 172 ? -11.99886 -22.59206 7.60763   1.000 43.26003  ? 172 HIS A CD2  1 
ATOM   2488 C CE1  . HIS A 1 172 ? -10.72398 -21.51737 9.03174   1.000 44.50236  ? 172 HIS A CE1  1 
ATOM   2489 N NE2  . HIS A 1 172 ? -10.76044 -22.03832 7.81809   1.000 44.34359  ? 172 HIS A NE2  1 
ATOM   2490 H H    . HIS A 1 172 ? -15.01773 -20.30788 9.35396   1.000 47.86194  ? 172 HIS A H    1 
ATOM   2491 H HA   . HIS A 1 172 ? -15.10924 -22.18166 7.37836   1.000 42.88124  ? 172 HIS A HA   1 
ATOM   2492 H HB2  . HIS A 1 172 ? -14.24592 -22.64686 10.03217  1.000 43.03166  ? 172 HIS A HB2  1 
ATOM   2493 H HB3  . HIS A 1 172 ? -14.23799 -23.72328 8.86312   1.000 43.03166  ? 172 HIS A HB3  1 
ATOM   2494 H HD2  . HIS A 1 172 ? -12.28885 -23.01752 6.83317   1.000 52.64810  ? 172 HIS A HD2  1 
ATOM   2495 H HE1  . HIS A 1 172 ? -9.99704  -21.08223 9.41531   1.000 54.13891  ? 172 HIS A HE1  1 
ATOM   2496 H HE2  . HIS A 1 172 ? -10.11327 -22.03160 7.25177   1.000 53.94837  ? 172 HIS A HE2  1 
ATOM   2497 N N    . ALA A 1 173 ? -17.17610 -23.27427 8.01155   1.000 31.96891  ? 173 ALA A N    1 
ATOM   2498 C CA   . ALA A 1 173 ? -18.53496 -23.72963 8.24628   1.000 28.16067  ? 173 ALA A CA   1 
ATOM   2499 C C    . ALA A 1 173 ? -18.56074 -25.24908 8.19311   1.000 27.26920  ? 173 ALA A C    1 
ATOM   2500 O O    . ALA A 1 173 ? -17.76644 -25.87529 7.48741   1.000 30.20156  ? 173 ALA A O    1 
ATOM   2501 C CB   . ALA A 1 173 ? -19.50724 -23.14739 7.21287   1.000 30.93740  ? 173 ALA A CB   1 
ATOM   2502 H H    . ALA A 1 173 ? -16.80204 -23.65791 7.33887   1.000 39.09876  ? 173 ALA A H    1 
ATOM   2503 H HA   . ALA A 1 173 ? -18.83454 -23.44856 9.12500   1.000 34.52887  ? 173 ALA A HA   1 
ATOM   2504 H HB1  . ALA A 1 173 ? -20.40410 -23.45802 7.41298   1.000 37.86095  ? 173 ALA A HB1  1 
ATOM   2505 H HB2  . ALA A 1 173 ? -19.47457 -22.17904 7.25904   1.000 37.86095  ? 173 ALA A HB2  1 
ATOM   2506 H HB3  . ALA A 1 173 ? -19.24363 -23.44545 6.32824   1.000 37.86095  ? 173 ALA A HB3  1 
ATOM   2507 N N    . GLY A 1 174 ? -19.48176 -25.83465 8.94669   1.000 25.57145  ? 174 GLY A N    1 
ATOM   2508 C CA   . GLY A 1 174 ? -19.58430 -27.27226 9.01593   1.000 25.73226  ? 174 GLY A CA   1 
ATOM   2509 C C    . GLY A 1 174 ? -20.90512 -27.70040 9.61072   1.000 27.20803  ? 174 GLY A C    1 
ATOM   2510 O O    . GLY A 1 174 ? -21.80613 -26.88863 9.82580   1.000 25.43454  ? 174 GLY A O    1 
ATOM   2511 H H    . GLY A 1 174 ? -20.05863 -25.41507 9.42708   1.000 31.42181  ? 174 GLY A H    1 
ATOM   2512 H HA2  . GLY A 1 174 ? -19.50976 -27.64729 8.12447   1.000 31.61478  ? 174 GLY A HA2  1 
ATOM   2513 H HA3  . GLY A 1 174 ? -18.86772 -27.62360 9.56727   1.000 31.61478  ? 174 GLY A HA3  1 
ATOM   2514 N N    . THR A 1 175 ? -20.99713 -28.99485 9.89323   1.000 25.34734  ? 175 THR A N    1 
ATOM   2515 C CA   . THR A 1 175 ? -22.23380 -29.63100 10.31283  1.000 25.98868  ? 175 THR A CA   1 
ATOM   2516 C C    . THR A 1 175 ? -22.05316 -30.32641 11.66037  1.000 27.62328  ? 175 THR A C    1 
ATOM   2517 O O    . THR A 1 175 ? -20.93847 -30.48737 12.16331  1.000 24.93159  ? 175 THR A O    1 
ATOM   2518 C CB   . THR A 1 175 ? -22.69790 -30.66603 9.27171   1.000 27.40917  ? 175 THR A CB   1 
ATOM   2519 O OG1  . THR A 1 175 ? -21.81898 -31.79982 9.31462   1.000 26.80696  ? 175 THR A OG1  1 
ATOM   2520 C CG2  . THR A 1 175 ? -22.69095 -30.08406 7.86161   1.000 26.42372  ? 175 THR A CG2  1 
ATOM   2521 H H    . THR A 1 175 ? -20.33373 -29.54014 9.84678   1.000 31.15287  ? 175 THR A H    1 
ATOM   2522 H HA   . THR A 1 175 ? -22.91174 -28.94429 10.41152  1.000 31.92248  ? 175 THR A HA   1 
ATOM   2523 H HB   . THR A 1 175 ? -23.60720 -30.93517 9.47575   1.000 33.62707  ? 175 THR A HB   1 
ATOM   2524 H HG1  . THR A 1 175 ? -21.93567 -32.22693 10.02846  1.000 32.90442  ? 175 THR A HG1  1 
ATOM   2525 H HG21 . THR A 1 175 ? -22.98917 -30.75269 7.22529   1.000 32.44453  ? 175 THR A HG21 1 
ATOM   2526 H HG22 . THR A 1 175 ? -23.28505 -29.31866 7.81567   1.000 32.44453  ? 175 THR A HG22 1 
ATOM   2527 H HG23 . THR A 1 175 ? -21.79410 -29.80115 7.62388   1.000 32.44453  ? 175 THR A HG23 1 
ATOM   2528 N N    . ASP A 1 176 ? -23.17466 -30.74858 12.24505  1.000 27.30240  ? 176 ASP A N    1 
ATOM   2529 C CA   . ASP A 1 176 ? -23.14019 -31.72337 13.32545  1.000 27.02449  ? 176 ASP A CA   1 
ATOM   2530 C C    . ASP A 1 176 ? -22.87488 -33.10013 12.71554  1.000 28.29187  ? 176 ASP A C    1 
ATOM   2531 O O    . ASP A 1 176 ? -22.73805 -33.24986 11.49747  1.000 24.91335  ? 176 ASP A O    1 
ATOM   2532 C CB   . ASP A 1 176 ? -24.42916 -31.67092 14.14571  1.000 28.86446  ? 176 ASP A CB   1 
ATOM   2533 C CG   . ASP A 1 176 ? -25.67378 -32.00789 13.34150  1.000 30.67622  ? 176 ASP A CG   1 
ATOM   2534 O OD1  . ASP A 1 176 ? -25.59261 -32.78546 12.36108  1.000 30.61568  ? 176 ASP A OD1  1 
ATOM   2535 O OD2  . ASP A 1 176 ? -26.75627 -31.49845 13.70620  1.000 31.80401  ? 176 ASP A OD2  1 
ATOM   2536 H H    . ASP A 1 176 ? -23.96470 -30.48395 12.03195  1.000 33.49895  ? 176 ASP A H    1 
ATOM   2537 H HA   . ASP A 1 176 ? -22.42367 -31.51668 13.94575  1.000 33.16546  ? 176 ASP A HA   1 
ATOM   2538 H HB2  . ASP A 1 176 ? -24.36384 -32.30955 14.87287  1.000 35.37342  ? 176 ASP A HB2  1 
ATOM   2539 H HB3  . ASP A 1 176 ? -24.53857 -30.77464 14.50014  1.000 35.37342  ? 176 ASP A HB3  1 
ATOM   2540 N N    . LEU A 1 177 ? -22.78287 -34.12881 13.55046  1.000 27.48202  ? 177 LEU A N    1 
ATOM   2541 C CA   . LEU A 1 177 ? -22.49162 -35.45373 13.01336  1.000 27.19435  ? 177 LEU A CA   1 
ATOM   2542 C C    . LEU A 1 177 ? -23.72578 -36.13898 12.44385  1.000 27.55439  ? 177 LEU A C    1 
ATOM   2543 O O    . LEU A 1 177 ? -23.64177 -37.30095 12.03272  1.000 29.27817  ? 177 LEU A O    1 
ATOM   2544 C CB   . LEU A 1 177 ? -21.84680 -36.33273 14.07819  1.000 27.23507  ? 177 LEU A CB   1 
ATOM   2545 C CG   . LEU A 1 177 ? -20.31561 -36.30116 14.11180  1.000 26.86905  ? 177 LEU A CG   1 
ATOM   2546 C CD1  . LEU A 1 177 ? -19.72558 -36.98593 12.88057  1.000 28.37971  ? 177 LEU A CD1  1 
ATOM   2547 C CD2  . LEU A 1 177 ? -19.78898 -34.87072 14.22971  1.000 26.20882  ? 177 LEU A CD2  1 
ATOM   2548 H H    . LEU A 1 177 ? -22.88165 -34.08711 14.40375  1.000 33.71450  ? 177 LEU A H    1 
ATOM   2549 H HA   . LEU A 1 177 ? -21.84702 -35.36065 12.29453  1.000 33.36929  ? 177 LEU A HA   1 
ATOM   2550 H HB2  . LEU A 1 177 ? -22.16251 -36.04056 14.94759  1.000 33.41815  ? 177 LEU A HB2  1 
ATOM   2551 H HB3  . LEU A 1 177 ? -22.11497 -37.25130 13.91935  1.000 33.41815  ? 177 LEU A HB3  1 
ATOM   2552 H HG   . LEU A 1 177 ? -20.02375 -36.78919 14.89763  1.000 32.97893  ? 177 LEU A HG   1 
ATOM   2553 H HD11 . LEU A 1 177 ? -18.81763 -37.26400 13.07857  1.000 34.79171  ? 177 LEU A HD11 1 
ATOM   2554 H HD12 . LEU A 1 177 ? -20.26756 -37.75934 12.65922  1.000 34.79171  ? 177 LEU A HD12 1 
ATOM   2555 H HD13 . LEU A 1 177 ? -19.72557 -36.35919 12.14023  1.000 34.79171  ? 177 LEU A HD13 1 
ATOM   2556 H HD21 . LEU A 1 177 ? -18.82141 -34.89470 14.29390  1.000 32.18666  ? 177 LEU A HD21 1 
ATOM   2557 H HD22 . LEU A 1 177 ? -20.05599 -34.37004 13.44300  1.000 32.18666  ? 177 LEU A HD22 1 
ATOM   2558 H HD23 . LEU A 1 177 ? -20.16321 -34.46100 15.02532  1.000 32.18666  ? 177 LEU A HD23 1 
ATOM   2559 N N    . GLU A 1 178 ? -24.86432 -35.45227 12.41433  1.000 27.90454  ? 178 GLU A N    1 
ATOM   2560 C CA   . GLU A 1 178 ? -26.00958 -35.87562 11.62606  1.000 31.26376  ? 178 GLU A CA   1 
ATOM   2561 C C    . GLU A 1 178 ? -26.04980 -35.19434 10.26611  1.000 30.51519  ? 178 GLU A C    1 
ATOM   2562 O O    . GLU A 1 178 ? -26.96844 -35.44836 9.48634   1.000 33.54960  ? 178 GLU A O    1 
ATOM   2563 C CB   . GLU A 1 178 ? -27.30709 -35.60047 12.38462  1.000 33.37021  ? 178 GLU A CB   1 
ATOM   2564 C CG   . GLU A 1 178 ? -27.50266 -36.47370 13.60930  1.000 36.46058  ? 178 GLU A CG   1 
ATOM   2565 C CD   . GLU A 1 178 ? -28.77172 -36.12948 14.35871  1.000 45.25078  ? 178 GLU A CD   1 
ATOM   2566 O OE1  . GLU A 1 178 ? -29.12154 -34.93142 14.41843  1.000 57.94867  ? 178 GLU A OE1  1 
ATOM   2567 O OE2  . GLU A 1 178 ? -29.42548 -37.05539 14.87924  1.000 47.29089  ? 178 GLU A OE2  1 
ATOM   2568 H H    . GLU A 1 178 ? -24.99710 -34.72407 12.85217  1.000 34.22152  ? 178 GLU A H    1 
ATOM   2569 H HA   . GLU A 1 178 ? -25.95892 -36.83375 11.48346  1.000 38.25258  ? 178 GLU A HA   1 
ATOM   2570 H HB2  . GLU A 1 178 ? -27.30532 -34.67607 12.67851  1.000 40.78033  ? 178 GLU A HB2  1 
ATOM   2571 H HB3  . GLU A 1 178 ? -28.05541 -35.75739 11.78772  1.000 40.78033  ? 178 GLU A HB3  1 
ATOM   2572 H HG2  . GLU A 1 178 ? -27.55673 -37.40199 13.33317  1.000 44.48876  ? 178 GLU A HG2  1 
ATOM   2573 H HG3  . GLU A 1 178 ? -26.75256 -36.34993 14.21173  1.000 44.48876  ? 178 GLU A HG3  1 
ATOM   2574 N N    . GLY A 1 179 ? -25.08755 -34.32710 9.97001   1.000 29.26178  ? 179 GLY A N    1 
ATOM   2575 C CA   . GLY A 1 179 ? -25.00142 -33.69443 8.67253   1.000 28.97371  ? 179 GLY A CA   1 
ATOM   2576 C C    . GLY A 1 179 ? -25.79135 -32.41702 8.51325   1.000 29.29133  ? 179 GLY A C    1 
ATOM   2577 O O    . GLY A 1 179 ? -25.90124 -31.91339 7.38926   1.000 27.95910  ? 179 GLY A O    1 
ATOM   2578 H H    . GLY A 1 179 ? -24.46666 -34.08912 10.51540  1.000 35.85021  ? 179 GLY A H    1 
ATOM   2579 H HA2  . GLY A 1 179 ? -24.07101 -33.48704 8.49302   1.000 35.50452  ? 179 GLY A HA2  1 
ATOM   2580 H HA3  . GLY A 1 179 ? -25.32014 -34.32051 8.00369   1.000 35.50452  ? 179 GLY A HA3  1 
ATOM   2581 N N    . ASN A 1 180 ? -26.34753 -31.87638 9.58942   1.000 28.06596  ? 180 ASN A N    1 
ATOM   2582 C CA   . ASN A 1 180 ? -27.09204 -30.62644 9.52734   1.000 28.65090  ? 180 ASN A CA   1 
ATOM   2583 C C    . ASN A 1 180 ? -26.13213 -29.46975 9.76562   1.000 28.40748  ? 180 ASN A C    1 
ATOM   2584 O O    . ASN A 1 180 ? -25.50570 -29.38788 10.82747  1.000 27.93411  ? 180 ASN A O    1 
ATOM   2585 C CB   . ASN A 1 180 ? -28.21592 -30.62400 10.55711  1.000 31.28466  ? 180 ASN A CB   1 
ATOM   2586 C CG   . ASN A 1 180 ? -29.21835 -31.73702 10.32397  1.000 32.87056  ? 180 ASN A CG   1 
ATOM   2587 O OD1  . ASN A 1 180 ? -29.76648 -31.87865 9.23254   1.000 36.27084  ? 180 ASN A OD1  1 
ATOM   2588 N ND2  . ASN A 1 180 ? -29.45194 -32.54406 11.35225  1.000 36.68030  ? 180 ASN A ND2  1 
ATOM   2589 H H    . ASN A 1 180 ? -26.30707 -32.21899 10.37719  1.000 34.41522  ? 180 ASN A H    1 
ATOM   2590 H HA   . ASN A 1 180 ? -27.48870 -30.52057 8.64851   1.000 35.11714  ? 180 ASN A HA   1 
ATOM   2591 H HB2  . ASN A 1 180 ? -27.83576 -30.74162 11.44173  1.000 38.27766  ? 180 ASN A HB2  1 
ATOM   2592 H HB3  . ASN A 1 180 ? -28.68844 -29.77825 10.50884  1.000 38.27766  ? 180 ASN A HB3  1 
ATOM   2593 H HD21 . ASN A 1 180 ? -30.01224 -33.19155 11.27208  1.000 44.75243  ? 180 ASN A HD21 1 
ATOM   2594 H HD22 . ASN A 1 180 ? -29.04292 -32.41927 12.09839  1.000 44.75243  ? 180 ASN A HD22 1 
ATOM   2595 N N    . PHE A 1 181 ? -26.01288 -28.58508 8.77948   1.000 28.93628  ? 181 PHE A N    1 
ATOM   2596 C CA   . PHE A 1 181 ? -25.10664 -27.45616 8.91093   1.000 26.80613  ? 181 PHE A CA   1 
ATOM   2597 C C    . PHE A 1 181 ? -25.44323 -26.62900 10.14281  1.000 27.54664  ? 181 PHE A C    1 
ATOM   2598 O O    . PHE A 1 181 ? -26.60801 -26.48853 10.52439  1.000 26.30762  ? 181 PHE A O    1 
ATOM   2599 C CB   . PHE A 1 181 ? -25.16581 -26.57280 7.66460   1.000 28.44792  ? 181 PHE A CB   1 
ATOM   2600 C CG   . PHE A 1 181 ? -24.05579 -26.83420 6.70154   1.000 26.64696  ? 181 PHE A CG   1 
ATOM   2601 C CD1  . PHE A 1 181 ? -22.83828 -26.18633 6.83618   1.000 25.81425  ? 181 PHE A CD1  1 
ATOM   2602 C CD2  . PHE A 1 181 ? -24.21362 -27.74342 5.67162   1.000 26.83735  ? 181 PHE A CD2  1 
ATOM   2603 C CE1  . PHE A 1 181 ? -21.80494 -26.43695 5.95582   1.000 26.59071  ? 181 PHE A CE1  1 
ATOM   2604 C CE2  . PHE A 1 181 ? -23.18404 -27.99448 4.79132   1.000 27.52092  ? 181 PHE A CE2  1 
ATOM   2605 C CZ   . PHE A 1 181 ? -21.97849 -27.34462 4.93283   1.000 26.68371  ? 181 PHE A CZ   1 
ATOM   2606 H H    . PHE A 1 181 ? -26.44108 -28.61746 8.03437   1.000 35.45960  ? 181 PHE A H    1 
ATOM   2607 H HA   . PHE A 1 181 ? -24.20190 -27.79291 9.00551   1.000 32.90342  ? 181 PHE A HA   1 
ATOM   2608 H HB2  . PHE A 1 181 ? -26.00400 -26.73568 7.20437   1.000 34.87358  ? 181 PHE A HB2  1 
ATOM   2609 H HB3  . PHE A 1 181 ? -25.11170 -25.64321 7.93630   1.000 34.87358  ? 181 PHE A HB3  1 
ATOM   2610 H HD1  . PHE A 1 181 ? -22.71599 -25.57603 7.52717   1.000 31.71316  ? 181 PHE A HD1  1 
ATOM   2611 H HD2  . PHE A 1 181 ? -25.02326 -28.19007 5.57219   1.000 32.94089  ? 181 PHE A HD2  1 
ATOM   2612 H HE1  . PHE A 1 181 ? -20.99290 -25.99411 6.05269   1.000 32.64492  ? 181 PHE A HE1  1 
ATOM   2613 H HE2  . PHE A 1 181 ? -23.30364 -28.60455 4.09965   1.000 33.76117  ? 181 PHE A HE2  1 
ATOM   2614 H HZ   . PHE A 1 181 ? -21.28317 -27.51752 4.33993   1.000 32.75652  ? 181 PHE A HZ   1 
ATOM   2615 N N    . TYR A 1 182 ? -24.40721 -26.10791 10.78794  1.000 25.85412  ? 182 TYR A N    1 
ATOM   2616 C CA   . TYR A 1 182 ? -24.57735 -24.96838 11.67680  1.000 25.90193  ? 182 TYR A CA   1 
ATOM   2617 C C    . TYR A 1 182 ? -24.70550 -23.72723 10.80015  1.000 27.07362  ? 182 TYR A C    1 
ATOM   2618 O O    . TYR A 1 182 ? -23.90337 -23.52372 9.88295   1.000 28.98236  ? 182 TYR A O    1 
ATOM   2619 C CB   . TYR A 1 182 ? -23.40470 -24.84938 12.64212  1.000 26.54912  ? 182 TYR A CB   1 
ATOM   2620 C CG   . TYR A 1 182 ? -23.34217 -25.96331 13.67234  1.000 26.03886  ? 182 TYR A CG   1 
ATOM   2621 C CD1  . TYR A 1 182 ? -24.11393 -25.91522 14.82763  1.000 27.39961  ? 182 TYR A CD1  1 
ATOM   2622 C CD2  . TYR A 1 182 ? -22.50860 -27.05942 13.48924  1.000 25.38365  ? 182 TYR A CD2  1 
ATOM   2623 C CE1  . TYR A 1 182 ? -24.05704 -26.92960 15.77167  1.000 28.05338  ? 182 TYR A CE1  1 
ATOM   2624 C CE2  . TYR A 1 182 ? -22.44343 -28.07462 14.42790  1.000 24.79124  ? 182 TYR A CE2  1 
ATOM   2625 C CZ   . TYR A 1 182 ? -23.22059 -28.00546 15.56567  1.000 27.03883  ? 182 TYR A CZ   1 
ATOM   2626 O OH   . TYR A 1 182 ? -23.15869 -29.01538 16.50221  1.000 27.63709  ? 182 TYR A OH   1 
ATOM   2627 H H    . TYR A 1 182 ? -23.59889 -26.39532 10.72777  1.000 31.76102  ? 182 TYR A H    1 
ATOM   2628 H HA   . TYR A 1 182 ? -25.37051 -25.06548 12.22668  1.000 31.81838  ? 182 TYR A HA   1 
ATOM   2629 H HB2  . TYR A 1 182 ? -22.57907 -24.87039 12.13340  1.000 32.59502  ? 182 TYR A HB2  1 
ATOM   2630 H HB3  . TYR A 1 182 ? -23.47865 -24.00848 13.11995  1.000 32.59502  ? 182 TYR A HB3  1 
ATOM   2631 H HD1  . TYR A 1 182 ? -24.67840 -25.18995 14.96998  1.000 33.61560  ? 182 TYR A HD1  1 
ATOM   2632 H HD2  . TYR A 1 182 ? -21.98508 -27.11207 12.72239  1.000 31.19645  ? 182 TYR A HD2  1 
ATOM   2633 H HE1  . TYR A 1 182 ? -24.58023 -26.88413 16.53920  1.000 34.40012  ? 182 TYR A HE1  1 
ATOM   2634 H HE2  . TYR A 1 182 ? -21.87801 -28.80041 14.29213  1.000 30.48555  ? 182 TYR A HE2  1 
ATOM   2635 H HH   . TYR A 1 182 ? -22.61789 -29.60714 16.25127  1.000 33.90057  ? 182 TYR A HH   1 
ATOM   2636 N N    . GLY A 1 183 ? -25.74054 -22.92969 11.04076  1.000 27.97236  ? 183 GLY A N    1 
ATOM   2637 C CA   . GLY A 1 183 ? -25.92875 -21.70222 10.30699  1.000 25.98005  ? 183 GLY A CA   1 
ATOM   2638 C C    . GLY A 1 183 ? -26.59304 -21.91499 8.96199   1.000 28.96000  ? 183 GLY A C    1 
ATOM   2639 O O    . GLY A 1 183 ? -27.03372 -23.01682 8.62763   1.000 27.13886  ? 183 GLY A O    1 
ATOM   2640 H H    . GLY A 1 183 ? -26.34758 -23.08538 11.62971  1.000 34.30290  ? 183 GLY A H    1 
ATOM   2641 H HA2  . GLY A 1 183 ? -26.48392 -21.10106 10.82784  1.000 31.91213  ? 183 GLY A HA2  1 
ATOM   2642 H HA3  . GLY A 1 183 ? -25.06611 -21.28490 10.15666  1.000 31.91213  ? 183 GLY A HA3  1 
ATOM   2643 N N    . PRO A 1 184 ? -26.67336 -20.85393 8.15823   1.000 30.30330  ? 184 PRO A N    1 
ATOM   2644 C CA   . PRO A 1 184 ? -27.39062 -20.92790 6.87737   1.000 30.37848  ? 184 PRO A CA   1 
ATOM   2645 C C    . PRO A 1 184 ? -26.59587 -21.54130 5.73690   1.000 30.77742  ? 184 PRO A C    1 
ATOM   2646 O O    . PRO A 1 184 ? -27.04315 -21.47224 4.58969   1.000 31.72291  ? 184 PRO A O    1 
ATOM   2647 C CB   . PRO A 1 184 ? -27.69070 -19.44830 6.58421   1.000 32.90850  ? 184 PRO A CB   1 
ATOM   2648 C CG   . PRO A 1 184 ? -26.49508 -18.72985 7.15845   1.000 34.44274  ? 184 PRO A CG   1 
ATOM   2649 C CD   . PRO A 1 184 ? -26.06796 -19.52519 8.38208   1.000 31.72695  ? 184 PRO A CD   1 
ATOM   2650 H HA   . PRO A 1 184 ? -28.22281 -21.41459 6.98461   1.000 37.19024  ? 184 PRO A HA   1 
ATOM   2651 H HB2  . PRO A 1 184 ? -27.76446 -19.30266 5.62805   1.000 40.22627  ? 184 PRO A HB2  1 
ATOM   2652 H HB3  . PRO A 1 184 ? -28.51095 -19.17721 7.02534   1.000 40.22627  ? 184 PRO A HB3  1 
ATOM   2653 H HG2  . PRO A 1 184 ? -25.78282 -18.70573 6.50042   1.000 42.06736  ? 184 PRO A HG2  1 
ATOM   2654 H HG3  . PRO A 1 184 ? -26.74683 -17.82697 7.40810   1.000 42.06736  ? 184 PRO A HG3  1 
ATOM   2655 H HD2  . PRO A 1 184 ? -25.10137 -19.59073 8.43013   1.000 38.80840  ? 184 PRO A HD2  1 
ATOM   2656 H HD3  . PRO A 1 184 ? -26.41383 -19.12133 9.19336   1.000 38.80840  ? 184 PRO A HD3  1 
ATOM   2657 N N    . PHE A 1 185 ? -25.44496 -22.14134 6.00998   1.000 28.93480  ? 185 PHE A N    1 
ATOM   2658 C CA   . PHE A 1 185 ? -24.50009 -22.46170 4.95215   1.000 29.44501  ? 185 PHE A CA   1 
ATOM   2659 C C    . PHE A 1 185 ? -24.86110 -23.76992 4.26260   1.000 29.46531  ? 185 PHE A C    1 
ATOM   2660 O O    . PHE A 1 185 ? -25.54558 -24.63124 4.82367   1.000 27.47903  ? 185 PHE A O    1 
ATOM   2661 C CB   . PHE A 1 185 ? -23.09257 -22.51770 5.54181   1.000 27.88606  ? 185 PHE A CB   1 
ATOM   2662 C CG   . PHE A 1 185 ? -22.72179 -21.28292 6.32236   1.000 29.55435  ? 185 PHE A CG   1 
ATOM   2663 C CD1  . PHE A 1 185 ? -22.60159 -20.06113 5.68417   1.000 31.07039  ? 185 PHE A CD1  1 
ATOM   2664 C CD2  . PHE A 1 185 ? -22.51313 -21.34041 7.68774   1.000 28.50983  ? 185 PHE A CD2  1 
ATOM   2665 C CE1  . PHE A 1 185 ? -22.27129 -18.92069 6.39091   1.000 33.83008  ? 185 PHE A CE1  1 
ATOM   2666 C CE2  . PHE A 1 185 ? -22.18195 -20.19982 8.40292   1.000 30.34677  ? 185 PHE A CE2  1 
ATOM   2667 C CZ   . PHE A 1 185 ? -22.05980 -18.99115 7.75204   1.000 31.57693  ? 185 PHE A CZ   1 
ATOM   2668 H H    . PHE A 1 185 ? -25.18898 -22.37248 6.79779   1.000 35.45783  ? 185 PHE A H    1 
ATOM   2669 H HA   . PHE A 1 185 ? -24.51891 -21.77828 4.26404   1.000 36.07008  ? 185 PHE A HA   1 
ATOM   2670 H HB2  . PHE A 1 185 ? -23.03411 -23.27777 6.14162   1.000 34.19934  ? 185 PHE A HB2  1 
ATOM   2671 H HB3  . PHE A 1 185 ? -22.45354 -22.61582 4.81868   1.000 34.19934  ? 185 PHE A HB3  1 
ATOM   2672 H HD1  . PHE A 1 185 ? -22.74509 -20.00678 4.76692   1.000 38.02054  ? 185 PHE A HD1  1 
ATOM   2673 H HD2  . PHE A 1 185 ? -22.59586 -22.15346 8.13159   1.000 34.94787  ? 185 PHE A HD2  1 
ATOM   2674 H HE1  . PHE A 1 185 ? -22.19164 -18.10619 5.94916   1.000 41.33216  ? 185 PHE A HE1  1 
ATOM   2675 H HE2  . PHE A 1 185 ? -22.04234 -20.25027 9.32100   1.000 37.15219  ? 185 PHE A HE2  1 
ATOM   2676 H HZ   . PHE A 1 185 ? -21.83538 -18.22515 8.22930   1.000 38.62839  ? 185 PHE A HZ   1 
ATOM   2677 N N    . VAL A 1 186 ? -24.40767 -23.89329 3.01132   1.000 29.06668  ? 186 VAL A N    1 
ATOM   2678 C CA   . VAL A 1 186 ? -24.65130 -25.05727 2.16974   1.000 30.73062  ? 186 VAL A CA   1 
ATOM   2679 C C    . VAL A 1 186 ? -23.32128 -25.55617 1.61913   1.000 30.30047  ? 186 VAL A C    1 
ATOM   2680 O O    . VAL A 1 186 ? -22.35190 -24.80411 1.50143   1.000 30.03972  ? 186 VAL A O    1 
ATOM   2681 C CB   . VAL A 1 186 ? -25.62264 -24.74085 1.00645   1.000 32.67004  ? 186 VAL A CB   1 
ATOM   2682 C CG1  . VAL A 1 186 ? -27.00682 -24.44072 1.54787   1.000 34.46516  ? 186 VAL A CG1  1 
ATOM   2683 C CG2  . VAL A 1 186 ? -25.10686 -23.57193 0.17245   1.000 35.67108  ? 186 VAL A CG2  1 
ATOM   2684 H H    . VAL A 1 186 ? -23.93877 -23.28978 2.61697   1.000 35.61608  ? 186 VAL A H    1 
ATOM   2685 H HA   . VAL A 1 186 ? -25.03845 -25.76278 2.71128   1.000 37.61281  ? 186 VAL A HA   1 
ATOM   2686 H HB   . VAL A 1 186 ? -25.68079 -25.51631 0.42664   1.000 39.94012  ? 186 VAL A HB   1 
ATOM   2687 H HG11 . VAL A 1 186 ? -27.59097 -24.20734 0.80949   1.000 42.09426  ? 186 VAL A HG11 1 
ATOM   2688 H HG12 . VAL A 1 186 ? -27.34591 -25.22802 2.00182   1.000 42.09426  ? 186 VAL A HG12 1 
ATOM   2689 H HG13 . VAL A 1 186 ? -26.94844 -23.69928 2.17057   1.000 42.09426  ? 186 VAL A HG13 1 
ATOM   2690 H HG21 . VAL A 1 186 ? -25.72829 -23.40309 -0.55296  1.000 43.54137  ? 186 VAL A HG21 1 
ATOM   2691 H HG22 . VAL A 1 186 ? -25.03739 -22.78689 0.73796   1.000 43.54137  ? 186 VAL A HG22 1 
ATOM   2692 H HG23 . VAL A 1 186 ? -24.23465 -23.79997 -0.18551  1.000 43.54137  ? 186 VAL A HG23 1 
ATOM   2693 N N    . ASP A 1 187 ? -23.28535 -26.84291 1.25964   1.000 29.33048  ? 187 ASP A N    1 
ATOM   2694 C CA   . ASP A 1 187 ? -22.04525 -27.44888 0.76897   1.000 30.61232  ? 187 ASP A CA   1 
ATOM   2695 C C    . ASP A 1 187 ? -21.96868 -27.35576 -0.75865  1.000 33.91064  ? 187 ASP A C    1 
ATOM   2696 O O    . ASP A 1 187 ? -22.03204 -28.34393 -1.49022  1.000 36.36329  ? 187 ASP A O    1 
ATOM   2697 C CB   . ASP A 1 187 ? -21.90139 -28.89001 1.26258   1.000 30.37620  ? 187 ASP A CB   1 
ATOM   2698 C CG   . ASP A 1 187 ? -23.11771 -29.76721 0.97739   1.000 29.71113  ? 187 ASP A CG   1 
ATOM   2699 O OD1  . ASP A 1 187 ? -24.19064 -29.25150 0.60059   1.000 30.88877  ? 187 ASP A OD1  1 
ATOM   2700 O OD2  . ASP A 1 187 ? -22.99304 -30.99909 1.14976   1.000 31.82568  ? 187 ASP A OD2  1 
ATOM   2701 H H    . ASP A 1 187 ? -23.95776 -27.37817 1.29070   1.000 35.93264  ? 187 ASP A H    1 
ATOM   2702 H HA   . ASP A 1 187 ? -21.30532 -26.93604 1.13009   1.000 37.47085  ? 187 ASP A HA   1 
ATOM   2703 H HB2  . ASP A 1 187 ? -21.13671 -29.29464 0.82390   1.000 37.18751  ? 187 ASP A HB2  1 
ATOM   2704 H HB3  . ASP A 1 187 ? -21.76507 -28.87819 2.22288   1.000 37.18751  ? 187 ASP A HB3  1 
ATOM   2705 N N    . ARG A 1 188 ? -21.80952 -26.12141 -1.23228  1.000 36.22695  ? 188 ARG A N    1 
ATOM   2706 C CA   . ARG A 1 188 ? -21.47100 -25.85943 -2.62732  1.000 40.91534  ? 188 ARG A CA   1 
ATOM   2707 C C    . ARG A 1 188 ? -20.64362 -24.58114 -2.68483  1.000 40.97351  ? 188 ARG A C    1 
ATOM   2708 O O    . ARG A 1 188 ? -20.69877 -23.73971 -1.78595  1.000 38.48943  ? 188 ARG A O    1 
ATOM   2709 C CB   . ARG A 1 188 ? -22.72382 -25.77053 -3.51084  1.000 44.32435  ? 188 ARG A CB   1 
ATOM   2710 C CG   . ARG A 1 188 ? -23.80527 -24.78824 -3.06871  1.000 47.96924  ? 188 ARG A CG   1 
ATOM   2711 C CD   . ARG A 1 188 ? -25.16281 -25.18200 -3.67681  1.000 53.93162  ? 188 ARG A CD   1 
ATOM   2712 N NE   . ARG A 1 188 ? -25.76113 -24.13464 -4.49840  1.000 63.09630  ? 188 ARG A NE   1 
ATOM   2713 C CZ   . ARG A 1 188 ? -26.89738 -23.50873 -4.21619  1.000 70.14308  ? 188 ARG A CZ   1 
ATOM   2714 N NH1  . ARG A 1 188 ? -27.59659 -23.79817 -3.13050  1.000 66.04332  ? 188 ARG A NH1  1 
ATOM   2715 N NH2  . ARG A 1 188 ? -27.34656 -22.57512 -5.05001  1.000 89.81699  ? 188 ARG A NH2  1 
ATOM   2716 H H    . ARG A 1 188 ? -21.89366 -25.40893 -0.75805  1.000 44.20841  ? 188 ARG A H    1 
ATOM   2717 H HA   . ARG A 1 188 ? -20.92799 -26.58118 -2.98105  1.000 49.83448  ? 188 ARG A HA   1 
ATOM   2718 H HB2  . ARG A 1 188 ? -22.44544 -25.50417 -4.40104  1.000 53.92529  ? 188 ARG A HB2  1 
ATOM   2719 H HB3  . ARG A 1 188 ? -23.13363 -26.64921 -3.54041  1.000 53.92529  ? 188 ARG A HB3  1 
ATOM   2720 H HG2  . ARG A 1 188 ? -23.88280 -24.80202 -2.10191  1.000 58.29915  ? 188 ARG A HG2  1 
ATOM   2721 H HG3  . ARG A 1 188 ? -23.57760 -23.89497 -3.37058  1.000 58.29915  ? 188 ARG A HG3  1 
ATOM   2722 H HD2  . ARG A 1 188 ? -25.03966 -25.96399 -4.23737  1.000 65.45401  ? 188 ARG A HD2  1 
ATOM   2723 H HD3  . ARG A 1 188 ? -25.78139 -25.38362 -2.95736  1.000 65.45401  ? 188 ARG A HD3  1 
ATOM   2724 H HE   . ARG A 1 188 ? -25.34782 -23.90646 -5.21723  1.000 76.45163  ? 188 ARG A HE   1 
ATOM   2725 H HH11 . ARG A 1 188 ? -27.31739 -24.40441 -2.58817  1.000 79.98806  ? 188 ARG A HH11 1 
ATOM   2726 H HH12 . ARG A 1 188 ? -28.33015 -23.38002 -2.96731  1.000 79.98806  ? 188 ARG A HH12 1 
ATOM   2727 H HH21 . ARG A 1 188 ? -26.90224 -22.38389 -5.76106  1.000 108.51645 ? 188 ARG A HH21 1 
ATOM   2728 H HH22 . ARG A 1 188 ? -28.08135 -22.16263 -4.87815  1.000 108.51645 ? 188 ARG A HH22 1 
ATOM   2729 N N    . GLN A 1 189 ? -19.84585 -24.45188 -3.75061  1.000 43.94214  ? 189 GLN A N    1 
ATOM   2730 C CA   . GLN A 1 189 ? -18.97128 -23.28579 -3.92569  1.000 46.02973  ? 189 GLN A CA   1 
ATOM   2731 C C    . GLN A 1 189 ? -19.76437 -22.15441 -4.58428  1.000 45.01898  ? 189 GLN A C    1 
ATOM   2732 O O    . GLN A 1 189 ? -19.52860 -21.75029 -5.72949  1.000 46.36728  ? 189 GLN A O    1 
ATOM   2733 C CB   . GLN A 1 189 ? -17.74239 -23.63524 -4.75317  1.000 45.08580  ? 189 GLN A CB   1 
ATOM   2734 C CG   . GLN A 1 189 ? -16.57712 -24.21288 -3.95904  1.000 46.89413  ? 189 GLN A CG   1 
ATOM   2735 C CD   . GLN A 1 189 ? -16.06077 -23.26973 -2.87839  1.000 45.83133  ? 189 GLN A CD   1 
ATOM   2736 O OE1  . GLN A 1 189 ? -15.89673 -22.06813 -3.10157  1.000 43.92660  ? 189 GLN A OE1  1 
ATOM   2737 N NE2  . GLN A 1 189 ? -15.80687 -23.81598 -1.69700  1.000 52.12365  ? 189 GLN A NE2  1 
ATOM   2738 H H    . GLN A 1 189 ? -19.79301 -25.02734 -4.38752  1.000 53.46663  ? 189 GLN A H    1 
ATOM   2739 H HA   . GLN A 1 189 ? -18.67517 -22.99806 -3.04795  1.000 55.97175  ? 189 GLN A HA   1 
ATOM   2740 H HB2  . GLN A 1 189 ? -17.99676 -24.29412 -5.41805  1.000 54.83902  ? 189 GLN A HB2  1 
ATOM   2741 H HB3  . GLN A 1 189 ? -17.42612 -22.82868 -5.18945  1.000 54.83902  ? 189 GLN A HB3  1 
ATOM   2742 H HG2  . GLN A 1 189 ? -16.86644 -25.03160 -3.52672  1.000 57.00902  ? 189 GLN A HG2  1 
ATOM   2743 H HG3  . GLN A 1 189 ? -15.84442 -24.39959 -4.56665  1.000 57.00902  ? 189 GLN A HG3  1 
ATOM   2744 H HE21 . GLN A 1 189 ? -15.51356 -23.32858 -1.05201  1.000 63.28445  ? 189 GLN A HE21 1 
ATOM   2745 H HE22 . GLN A 1 189 ? -15.93553 -24.65762 -1.57583  1.000 63.28445  ? 189 GLN A HE22 1 
ATOM   2746 N N    . THR A 1 190 ? -20.71764 -21.62529 -3.82411  1.000 43.37449  ? 190 THR A N    1 
ATOM   2747 C CA   . THR A 1 190 ? -21.47896 -20.44714 -4.21379  1.000 47.36380  ? 190 THR A CA   1 
ATOM   2748 C C    . THR A 1 190 ? -21.17131 -19.30192 -3.25636  1.000 48.94328  ? 190 THR A C    1 
ATOM   2749 O O    . THR A 1 190 ? -20.48745 -19.47009 -2.24323  1.000 47.76773  ? 190 THR A O    1 
ATOM   2750 C CB   . THR A 1 190 ? -22.98485 -20.73554 -4.23221  1.000 49.43885  ? 190 THR A CB   1 
ATOM   2751 O OG1  . THR A 1 190 ? -23.69263 -19.56437 -4.66393  1.000 51.59435  ? 190 THR A OG1  1 
ATOM   2752 C CG2  . THR A 1 190 ? -23.48055 -21.13516 -2.85438  1.000 49.96998  ? 190 THR A CG2  1 
ATOM   2753 H H    . THR A 1 190 ? -20.94630 -21.94116 -3.05759  1.000 52.78545  ? 190 THR A H    1 
ATOM   2754 H HA   . THR A 1 190 ? -21.22028 -20.18469 -5.11107  1.000 57.57263  ? 190 THR A HA   1 
ATOM   2755 H HB   . THR A 1 190 ? -23.15960 -21.46961 -4.84172  1.000 60.06269  ? 190 THR A HB   1 
ATOM   2756 H HG1  . THR A 1 190 ? -24.47010 -19.77127 -4.90547  1.000 62.64929  ? 190 THR A HG1  1 
ATOM   2757 H HG21 . THR A 1 190 ? -24.32709 -21.60279 -2.92910  1.000 60.70005  ? 190 THR A HG21 1 
ATOM   2758 H HG22 . THR A 1 190 ? -22.83514 -21.71900 -2.42605  1.000 60.70005  ? 190 THR A HG22 1 
ATOM   2759 H HG23 . THR A 1 190 ? -23.60446 -20.34572 -2.30453  1.000 60.70005  ? 190 THR A HG23 1 
ATOM   2760 N N    . ALA A 1 191 ? -21.68161 -18.12096 -3.59453  1.000 51.07198  ? 191 ALA A N    1 
ATOM   2761 C CA   . ALA A 1 191 ? -21.47253 -16.94381 -2.76088  1.000 51.96598  ? 191 ALA A CA   1 
ATOM   2762 C C    . ALA A 1 191 ? -22.26812 -17.08789 -1.47044  1.000 52.35548  ? 191 ALA A C    1 
ATOM   2763 O O    . ALA A 1 191 ? -23.50024 -17.17644 -1.49971  1.000 52.81879  ? 191 ALA A O    1 
ATOM   2764 C CB   . ALA A 1 191 ? -21.88376 -15.68209 -3.51384  1.000 60.34398  ? 191 ALA A CB   1 
ATOM   2765 H H    . ALA A 1 191 ? -22.15137 -17.97618 -4.30019  1.000 62.02244  ? 191 ALA A H    1 
ATOM   2766 H HA   . ALA A 1 191 ? -20.53174 -16.86515 -2.53812  1.000 63.09524  ? 191 ALA A HA   1 
ATOM   2767 H HB1  . ALA A 1 191 ? -21.75414 -14.91343 -2.93655  1.000 73.14884  ? 191 ALA A HB1  1 
ATOM   2768 H HB2  . ALA A 1 191 ? -21.33430 -15.59534 -4.30850  1.000 73.14884  ? 191 ALA A HB2  1 
ATOM   2769 H HB3  . ALA A 1 191 ? -22.81817 -15.75405 -3.76402  1.000 73.14884  ? 191 ALA A HB3  1 
ATOM   2770 N N    . GLN A 1 192 ? -21.56447 -17.11518 -0.34027  1.000 51.75612  ? 192 GLN A N    1 
ATOM   2771 C CA   . GLN A 1 192 ? -22.19108 -17.30080 0.96001   1.000 50.09770  ? 192 GLN A CA   1 
ATOM   2772 C C    . GLN A 1 192 ? -21.57668 -16.33583 1.95906   1.000 52.42880  ? 192 GLN A C    1 
ATOM   2773 O O    . GLN A 1 192 ? -20.35092 -16.27669 2.09299   1.000 56.40610  ? 192 GLN A O    1 
ATOM   2774 C CB   . GLN A 1 192 ? -22.01424 -18.73228 1.46994   1.000 46.95280  ? 192 GLN A CB   1 
ATOM   2775 C CG   . GLN A 1 192 ? -22.67284 -19.78869 0.63086   1.000 44.77245  ? 192 GLN A CG   1 
ATOM   2776 C CD   . GLN A 1 192 ? -22.54214 -21.15850 1.25211   1.000 39.61070  ? 192 GLN A CD   1 
ATOM   2777 O OE1  . GLN A 1 192 ? -23.12333 -21.43127 2.30376   1.000 32.59844  ? 192 GLN A OE1  1 
ATOM   2778 N NE2  . GLN A 1 192 ? -21.76220 -22.02474 0.61706   1.000 38.35534  ? 192 GLN A NE2  1 
ATOM   2779 H H    . GLN A 1 192 ? -20.70982 -17.02677 -0.30330  1.000 62.84341  ? 192 GLN A H    1 
ATOM   2780 H HA   . GLN A 1 192 ? -23.13871 -17.11003 0.87933   1.000 60.85331  ? 192 GLN A HA   1 
ATOM   2781 H HB2  . GLN A 1 192 ? -21.06570 -18.93307 1.49914   1.000 57.07943  ? 192 GLN A HB2  1 
ATOM   2782 H HB3  . GLN A 1 192 ? -22.39317 -18.79004 2.36100   1.000 57.07943  ? 192 GLN A HB3  1 
ATOM   2783 H HG2  . GLN A 1 192 ? -23.61677 -19.58397 0.54152   1.000 54.46301  ? 192 GLN A HG2  1 
ATOM   2784 H HG3  . GLN A 1 192 ? -22.25377 -19.81004 -0.24368  1.000 54.46301  ? 192 GLN A HG3  1 
ATOM   2785 H HE21 . GLN A 1 192 ? -21.36346 -21.79258 -0.10869  1.000 46.76248  ? 192 GLN A HE21 1 
ATOM   2786 H HE22 . GLN A 1 192 ? -21.65562 -22.81812 0.93136   1.000 46.76248  ? 192 GLN A HE22 1 
ATOM   2787 N N    . ALA A 1 193 ? -22.42416 -15.59808 2.66684   1.000 52.86129  ? 193 ALA A N    1 
ATOM   2788 C CA   . ALA A 1 193 ? -21.98608 -14.63424 3.66535   1.000 55.58408  ? 193 ALA A CA   1 
ATOM   2789 C C    . ALA A 1 193 ? -22.43653 -15.08426 5.04834   1.000 50.64090  ? 193 ALA A C    1 
ATOM   2790 O O    . ALA A 1 193 ? -23.53459 -15.62646 5.21084   1.000 45.17252  ? 193 ALA A O    1 
ATOM   2791 C CB   . ALA A 1 193 ? -22.53693 -13.23910 3.35895   1.000 78.34289  ? 193 ALA A CB   1 
ATOM   2792 H H    . ALA A 1 193 ? -23.27905 -15.64017 2.58331   1.000 64.16962  ? 193 ALA A H    1 
ATOM   2793 H HA   . ALA A 1 193 ? -21.01751 -14.58166 3.66551   1.000 67.43696  ? 193 ALA A HA   1 
ATOM   2794 H HB1  . ALA A 1 193 ? -22.21572 -12.61808 4.03129   1.000 94.74754  ? 193 ALA A HB1  1 
ATOM   2795 H HB2  . ALA A 1 193 ? -22.22973 -12.96410 2.48094   1.000 94.74754  ? 193 ALA A HB2  1 
ATOM   2796 H HB3  . ALA A 1 193 ? -23.50625 -13.27177 3.37500   1.000 94.74754  ? 193 ALA A HB3  1 
ATOM   2797 N N    . ALA A 1 194 ? -21.58442 -14.84347 6.04430   1.000 49.84238  ? 194 ALA A N    1 
ATOM   2798 C CA   . ALA A 1 194 ? -21.82537 -15.38377 7.37557   1.000 45.40218  ? 194 ALA A CA   1 
ATOM   2799 C C    . ALA A 1 194 ? -22.88356 -14.59453 8.13422   1.000 44.62243  ? 194 ALA A C    1 
ATOM   2800 O O    . ALA A 1 194 ? -23.64563 -15.17172 8.91690   1.000 46.68112  ? 194 ALA A O    1 
ATOM   2801 C CB   . ALA A 1 194 ? -20.51962 -15.40277 8.17428   1.000 42.75543  ? 194 ALA A CB   1 
ATOM   2802 H H    . ALA A 1 194 ? -20.86687 -14.37463 5.97415   1.000 60.54692  ? 194 ALA A H    1 
ATOM   2803 H HA   . ALA A 1 194 ? -22.14535 -16.29442 7.27954   1.000 55.21868  ? 194 ALA A HA   1 
ATOM   2804 H HB1  . ALA A 1 194 ? -20.69719 -15.75229 9.06152   1.000 52.04259  ? 194 ALA A HB1  1 
ATOM   2805 H HB2  . ALA A 1 194 ? -19.87836 -15.96955 7.71771   1.000 52.04259  ? 194 ALA A HB2  1 
ATOM   2806 H HB3  . ALA A 1 194 ? -20.17516 -14.49822 8.23793   1.000 52.04259  ? 194 ALA A HB3  1 
ATOM   2807 N N    . GLY A 1 195 ? -22.93959 -13.28423 7.93476   1.000 42.84654  ? 195 GLY A N    1 
ATOM   2808 C CA   . GLY A 1 195 ? -23.80513 -12.43525 8.72158   1.000 42.30959  ? 195 GLY A CA   1 
ATOM   2809 C C    . GLY A 1 195 ? -23.10500 -11.87322 9.94407   1.000 41.48892  ? 195 GLY A C    1 
ATOM   2810 O O    . GLY A 1 195 ? -22.03775 -12.32689 10.36403  1.000 38.84606  ? 195 GLY A O    1 
ATOM   2811 H H    . GLY A 1 195 ? -22.47919 -12.86392 7.34232   1.000 52.15192  ? 195 GLY A H    1 
ATOM   2812 H HA2  . GLY A 1 195 ? -24.11026 -11.69371 8.17576   1.000 51.50758  ? 195 GLY A HA2  1 
ATOM   2813 H HA3  . GLY A 1 195 ? -24.57420 -12.94691 9.01761   1.000 51.50758  ? 195 GLY A HA3  1 
ATOM   2814 N N    . THR A 1 196 ? -23.73989 -10.86133 10.53047  1.000 40.65445  ? 196 THR A N    1 
ATOM   2815 C CA   . THR A 1 196 ? -23.11495 -10.09089 11.59655  1.000 36.84946  ? 196 THR A CA   1 
ATOM   2816 C C    . THR A 1 196 ? -22.70938 -10.97908 12.76355  1.000 36.49528  ? 196 THR A C    1 
ATOM   2817 O O    . THR A 1 196 ? -23.55517 -11.62877 13.38643  1.000 37.50927  ? 196 THR A O    1 
ATOM   2818 C CB   . THR A 1 196 ? -24.07484 -9.00541  12.07961  1.000 39.06944  ? 196 THR A CB   1 
ATOM   2819 O OG1  . THR A 1 196 ? -24.51180 -8.21325  10.96845  1.000 41.32738  ? 196 THR A OG1  1 
ATOM   2820 C CG2  . THR A 1 196 ? -23.39907 -8.10853  13.10317  1.000 41.59622  ? 196 THR A CG2  1 
ATOM   2821 H H    . THR A 1 196 ? -24.53433 -10.60161 10.32795  1.000 49.52141  ? 196 THR A H    1 
ATOM   2822 H HA   . THR A 1 196 ? -22.31221 -9.67580  11.24413  1.000 44.95542  ? 196 THR A HA   1 
ATOM   2823 H HB   . THR A 1 196 ? -24.84379 -9.42230  12.49893  1.000 47.61940  ? 196 THR A HB   1 
ATOM   2824 H HG1  . THR A 1 196 ? -25.25112 -7.85520  11.14397  1.000 50.32892  ? 196 THR A HG1  1 
ATOM   2825 H HG21 . THR A 1 196 ? -23.97584 -7.35939  13.32002  1.000 50.65153  ? 196 THR A HG21 1 
ATOM   2826 H HG22 . THR A 1 196 ? -23.21555 -8.60936  13.91334  1.000 50.65153  ? 196 THR A HG22 1 
ATOM   2827 H HG23 . THR A 1 196 ? -22.56318 -7.76935  12.74659  1.000 50.65153  ? 196 THR A HG23 1 
ATOM   2828 N N    . ASP A 1 197 ? -21.41596 -11.00376 13.06579  1.000 35.51120  ? 197 ASP A N    1 
ATOM   2829 C CA   . ASP A 1 197 ? -20.95061 -11.69469 14.25671  1.000 35.83816  ? 197 ASP A CA   1 
ATOM   2830 C C    . ASP A 1 197 ? -21.05391 -10.75362 15.45101  1.000 38.78956  ? 197 ASP A C    1 
ATOM   2831 O O    . ASP A 1 197 ? -20.99344 -9.52909  15.31586  1.000 40.67384  ? 197 ASP A O    1 
ATOM   2832 C CB   . ASP A 1 197 ? -19.51455 -12.18876 14.10168  1.000 36.39709  ? 197 ASP A CB   1 
ATOM   2833 C CG   . ASP A 1 197 ? -19.18383 -13.32831 15.06145  1.000 36.23330  ? 197 ASP A CG   1 
ATOM   2834 O OD1  . ASP A 1 197 ? -20.12349 -13.93220 15.63817  1.000 35.73200  ? 197 ASP A OD1  1 
ATOM   2835 O OD2  . ASP A 1 197 ? -17.98640 -13.62141 15.25014  1.000 35.42394  ? 197 ASP A OD2  1 
ATOM   2836 H H    . ASP A 1 197 ? -20.79651 -10.63087 12.60013  1.000 43.34950  ? 197 ASP A H    1 
ATOM   2837 H HA   . ASP A 1 197 ? -21.50011 -12.47850 14.41353  1.000 43.74187  ? 197 ASP A HA   1 
ATOM   2838 H HB2  . ASP A 1 197 ? -19.38582 -12.51084 13.19581  1.000 44.41257  ? 197 ASP A HB2  1 
ATOM   2839 H HB3  . ASP A 1 197 ? -18.90551 -11.45587 14.28290  1.000 44.41257  ? 197 ASP A HB3  1 
ATOM   2840 N N    . THR A 1 198 ? -21.23343 -11.33475 16.61853  1.000 34.90537  ? 198 THR A N    1 
ATOM   2841 C CA   . THR A 1 198 ? -21.31244 -10.59388 17.86202  1.000 35.84290  ? 198 THR A CA   1 
ATOM   2842 C C    . THR A 1 198 ? -20.41880 -11.29927 18.86777  1.000 33.89264  ? 198 THR A C    1 
ATOM   2843 O O    . THR A 1 198 ? -19.97927 -12.43140 18.65166  1.000 33.97560  ? 198 THR A O    1 
ATOM   2844 C CB   . THR A 1 198 ? -22.76038 -10.48713 18.34057  1.000 36.80147  ? 198 THR A CB   1 
ATOM   2845 O OG1  . THR A 1 198 ? -23.32966 -11.79064 18.47456  1.000 38.66646  ? 198 THR A OG1  1 
ATOM   2846 C CG2  . THR A 1 198 ? -23.58647 -9.68244  17.32696  1.000 36.59541  ? 198 THR A CG2  1 
ATOM   2847 H H    . THR A 1 198 ? -21.31517 -12.18462 16.72166  1.000 42.62252  ? 198 THR A H    1 
ATOM   2848 H HA   . THR A 1 198 ? -20.98961 -9.68414  17.76681  1.000 43.74755  ? 198 THR A HA   1 
ATOM   2849 H HB   . THR A 1 198 ? -22.78505 -10.03931 19.20066  1.000 44.89783  ? 198 THR A HB   1 
ATOM   2850 H HG1  . THR A 1 198 ? -23.35584 -12.17103 17.72609  1.000 47.13582  ? 198 THR A HG1  1 
ATOM   2851 H HG21 . THR A 1 198 ? -24.47989 -9.53079  17.67296  1.000 44.65056  ? 198 THR A HG21 1 
ATOM   2852 H HG22 . THR A 1 198 ? -23.16377 -8.82544  17.16029  1.000 44.65056  ? 198 THR A HG22 1 
ATOM   2853 H HG23 . THR A 1 198 ? -23.65126 -10.16946 16.49059  1.000 44.65056  ? 198 THR A HG23 1 
ATOM   2854 N N    . THR A 1 199 ? -20.11404 -10.60183 19.94948  1.000 32.26148  ? 199 THR A N    1 
ATOM   2855 C CA   . THR A 1 199 ? -19.25798 -11.14722 20.99035  1.000 31.55331  ? 199 THR A CA   1 
ATOM   2856 C C    . THR A 1 199 ? -20.10768 -11.87235 22.02586  1.000 32.08772  ? 199 THR A C    1 
ATOM   2857 O O    . THR A 1 199 ? -21.20629 -11.42818 22.37376  1.000 32.05666  ? 199 THR A O    1 
ATOM   2858 C CB   . THR A 1 199 ? -18.43466 -10.03156 21.63009  1.000 30.63996  ? 199 THR A CB   1 
ATOM   2859 O OG1  . THR A 1 199 ? -17.73061 -9.32148  20.60254  1.000 34.94900  ? 199 THR A OG1  1 
ATOM   2860 C CG2  . THR A 1 199 ? -17.43441 -10.59897 22.61020  1.000 31.78134  ? 199 THR A CG2  1 
ATOM   2861 H H    . THR A 1 199 ? -20.39266 -9.80340  20.10598  1.000 39.44985  ? 199 THR A H    1 
ATOM   2862 H HA   . THR A 1 199 ? -18.63581 -11.79162 20.61812  1.000 38.60004  ? 199 THR A HA   1 
ATOM   2863 H HB   . THR A 1 199 ? -19.02275 -9.42783  22.11025  1.000 37.50402  ? 199 THR A HB   1 
ATOM   2864 H HG1  . THR A 1 199 ? -17.23799 -8.73375  20.94534  1.000 42.67487  ? 199 THR A HG1  1 
ATOM   2865 H HG21 . THR A 1 199 ? -16.87997 -9.88778  22.96755  1.000 38.87367  ? 199 THR A HG21 1 
ATOM   2866 H HG22 . THR A 1 199 ? -17.89793 -11.03485 23.34236  1.000 38.87367  ? 199 THR A HG22 1 
ATOM   2867 H HG23 . THR A 1 199 ? -16.86647 -11.24803 22.16629  1.000 38.87367  ? 199 THR A HG23 1 
ATOM   2868 N N    . ILE A 1 200 ? -19.59912 -13.01427 22.48920  1.000 28.42458  ? 200 ILE A N    1 
ATOM   2869 C CA   . ILE A 1 200 ? -20.29996 -13.87265 23.43864  1.000 26.68026  ? 200 ILE A CA   1 
ATOM   2870 C C    . ILE A 1 200 ? -20.13475 -13.28373 24.83359  1.000 27.70538  ? 200 ILE A C    1 
ATOM   2871 O O    . ILE A 1 200 ? -19.15370 -13.56781 25.53112  1.000 25.67812  ? 200 ILE A O    1 
ATOM   2872 C CB   . ILE A 1 200 ? -19.77239 -15.31699 23.36458  1.000 25.85486  ? 200 ILE A CB   1 
ATOM   2873 C CG1  . ILE A 1 200 ? -19.77105 -15.80560 21.91292  1.000 27.91135  ? 200 ILE A CG1  1 
ATOM   2874 C CG2  . ILE A 1 200 ? -20.62086 -16.24353 24.22241  1.000 26.50633  ? 200 ILE A CG2  1 
ATOM   2875 C CD1  . ILE A 1 200 ? -18.86009 -16.99619 21.65733  1.000 27.79970  ? 200 ILE A CD1  1 
ATOM   2876 H H    . ILE A 1 200 ? -18.82846 -13.32058 22.26147  1.000 34.84556  ? 200 ILE A H    1 
ATOM   2877 H HA   . ILE A 1 200 ? -21.24677 -13.89397 23.22888  1.000 32.75238  ? 200 ILE A HA   1 
ATOM   2878 H HB   . ILE A 1 200 ? -18.86348 -15.32422 23.70331  1.000 31.76190  ? 200 ILE A HB   1 
ATOM   2879 H HG12 . ILE A 1 200 ? -20.67341 -16.06872 21.67330  1.000 34.22969  ? 200 ILE A HG12 1 
ATOM   2880 H HG13 . ILE A 1 200 ? -19.47429 -15.08003 21.34162  1.000 34.22969  ? 200 ILE A HG13 1 
ATOM   2881 H HG21 . ILE A 1 200 ? -20.28705 -17.14994 24.13362  1.000 32.54367  ? 200 ILE A HG21 1 
ATOM   2882 H HG22 . ILE A 1 200 ? -20.56250 -15.95871 25.14782  1.000 32.54367  ? 200 ILE A HG22 1 
ATOM   2883 H HG23 . ILE A 1 200 ? -21.54145 -16.19896 23.92004  1.000 32.54367  ? 200 ILE A HG23 1 
ATOM   2884 H HD11 . ILE A 1 200 ? -19.20126 -17.49818 20.90069  1.000 34.09571  ? 200 ILE A HD11 1 
ATOM   2885 H HD12 . ILE A 1 200 ? -17.96580 -16.67387 21.46430  1.000 34.09571  ? 200 ILE A HD12 1 
ATOM   2886 H HD13 . ILE A 1 200 ? -18.84568 -17.55823 22.44777  1.000 34.09571  ? 200 ILE A HD13 1 
ATOM   2887 N N    . THR A 1 201 ? -21.10371 -12.46433 25.24877  1.000 29.41456  ? 201 THR A N    1 
ATOM   2888 C CA   . THR A 1 201 ? -20.94096 -11.66330 26.45782  1.000 29.77514  ? 201 THR A CA   1 
ATOM   2889 C C    . THR A 1 201 ? -20.71165 -12.53754 27.68365  1.000 29.02857  ? 201 THR A C    1 
ATOM   2890 O O    . THR A 1 201 ? -19.85367 -12.23290 28.52069  1.000 27.45994  ? 201 THR A O    1 
ATOM   2891 C CB   . THR A 1 201 ? -22.16784 -10.76815 26.63135  1.000 32.31678  ? 201 THR A CB   1 
ATOM   2892 O OG1  . THR A 1 201 ? -22.39767 -10.05700 25.40810  1.000 30.38868  ? 201 THR A OG1  1 
ATOM   2893 C CG2  . THR A 1 201 ? -21.97013 -9.77137  27.76802  1.000 35.99955  ? 201 THR A CG2  1 
ATOM   2894 H H    . THR A 1 201 ? -21.85824 -12.35580 24.85064  1.000 36.03355  ? 201 THR A H    1 
ATOM   2895 H HA   . THR A 1 201 ? -20.15964 -11.09546 26.36839  1.000 36.46623  ? 201 THR A HA   1 
ATOM   2896 H HB   . THR A 1 201 ? -22.93882 -11.31396 26.85175  1.000 39.51621  ? 201 THR A HB   1 
ATOM   2897 H HG1  . THR A 1 201 ? -23.14885 -9.68175  25.43072  1.000 37.20249  ? 201 THR A HG1  1 
ATOM   2898 H HG21 . THR A 1 201 ? -22.69437 -9.12612  27.77317  1.000 43.93553  ? 201 THR A HG21 1 
ATOM   2899 H HG22 . THR A 1 201 ? -21.95716 -10.23684 28.61895  1.000 43.93553  ? 201 THR A HG22 1 
ATOM   2900 H HG23 . THR A 1 201 ? -21.12979 -9.30050  27.65394  1.000 43.93553  ? 201 THR A HG23 1 
ATOM   2901 N N    . VAL A 1 202 ? -21.44378 -13.64209 27.79817  1.000 28.30544  ? 202 VAL A N    1 
ATOM   2902 C CA   . VAL A 1 202 ? -21.30640 -14.49259 28.97783  1.000 29.13661  ? 202 VAL A CA   1 
ATOM   2903 C C    . VAL A 1 202 ? -19.88433 -15.04799 29.07047  1.000 28.67196  ? 202 VAL A C    1 
ATOM   2904 O O    . VAL A 1 202 ? -19.32022 -15.18503 30.16340  1.000 27.73239  ? 202 VAL A O    1 
ATOM   2905 C CB   . VAL A 1 202 ? -22.36824 -15.60911 28.95680  1.000 32.50268  ? 202 VAL A CB   1 
ATOM   2906 C CG1  . VAL A 1 202 ? -22.13151 -16.56708 27.79720  1.000 32.93428  ? 202 VAL A CG1  1 
ATOM   2907 C CG2  . VAL A 1 202 ? -22.39133 -16.33267 30.29977  1.000 32.33360  ? 202 VAL A CG2  1 
ATOM   2908 H H    . VAL A 1 202 ? -22.01671 -13.91742 27.21890  1.000 34.70259  ? 202 VAL A H    1 
ATOM   2909 H HA   . VAL A 1 202 ? -21.46230 -13.95591 29.77065  1.000 35.70001  ? 202 VAL A HA   1 
ATOM   2910 H HB   . VAL A 1 202 ? -23.24424 -15.21643 28.81774  1.000 39.73928  ? 202 VAL A HB   1 
ATOM   2911 H HG11 . VAL A 1 202 ? -22.90534 -17.14404 27.70120  1.000 40.25720  ? 202 VAL A HG11 1 
ATOM   2912 H HG12 . VAL A 1 202 ? -21.99917 -16.05334 26.98514  1.000 40.25720  ? 202 VAL A HG12 1 
ATOM   2913 H HG13 . VAL A 1 202 ? -21.34273 -17.09993 27.98376  1.000 40.25720  ? 202 VAL A HG13 1 
ATOM   2914 H HG21 . VAL A 1 202 ? -23.17292 -16.90598 30.33621  1.000 39.53639  ? 202 VAL A HG21 1 
ATOM   2915 H HG22 . VAL A 1 202 ? -21.58562 -16.86602 30.38503  1.000 39.53639  ? 202 VAL A HG22 1 
ATOM   2916 H HG23 . VAL A 1 202 ? -22.42978 -15.67532 31.01204  1.000 39.53639  ? 202 VAL A HG23 1 
ATOM   2917 N N    . ASN A 1 203 ? -19.27349 -15.35713 27.91992  1.000 28.56509  ? 203 ASN A N    1 
ATOM   2918 C CA   . ASN A 1 203 ? -17.90769 -15.87858 27.92169  1.000 26.43241  ? 203 ASN A CA   1 
ATOM   2919 C C    . ASN A 1 203 ? -16.89986 -14.81407 28.35063  1.000 28.27066  ? 203 ASN A C    1 
ATOM   2920 O O    . ASN A 1 203 ? -15.97227 -15.10138 29.11723  1.000 27.69678  ? 203 ASN A O    1 
ATOM   2921 C CB   . ASN A 1 203 ? -17.55324 -16.41887 26.53636  1.000 29.46887  ? 203 ASN A CB   1 
ATOM   2922 C CG   . ASN A 1 203 ? -18.34234 -17.66396 26.17205  1.000 29.39815  ? 203 ASN A CG   1 
ATOM   2923 O OD1  . ASN A 1 203 ? -19.14895 -18.15986 26.96056  1.000 29.50283  ? 203 ASN A OD1  1 
ATOM   2924 N ND2  . ASN A 1 203 ? -18.11626 -18.17455 24.96549  1.000 28.38684  ? 203 ASN A ND2  1 
ATOM   2925 H H    . ASN A 1 203 ? -19.62393 -15.27481 27.13888  1.000 35.01418  ? 203 ASN A H    1 
ATOM   2926 H HA   . ASN A 1 203 ? -17.85789 -16.60985 28.55704  1.000 32.45496  ? 203 ASN A HA   1 
ATOM   2927 H HB2  . ASN A 1 203 ? -17.74462 -15.73764 25.87289  1.000 36.09871  ? 203 ASN A HB2  1 
ATOM   2928 H HB3  . ASN A 1 203 ? -16.61018 -16.64510 26.51707  1.000 36.09871  ? 203 ASN A HB3  1 
ATOM   2929 H HD21 . ASN A 1 203 ? -18.53797 -18.87953 24.71098  1.000 34.80028  ? 203 ASN A HD21 1 
ATOM   2930 H HD22 . ASN A 1 203 ? -17.54831 -17.79986 24.43953  1.000 34.80028  ? 203 ASN A HD22 1 
ATOM   2931 N N    . VAL A 1 204 ? -17.05189 -13.58198 27.86097  1.000 27.39329  ? 204 VAL A N    1 
ATOM   2932 C CA   . VAL A 1 204 ? -16.15779 -12.51021 28.29549  1.000 26.74146  ? 204 VAL A CA   1 
ATOM   2933 C C    . VAL A 1 204 ? -16.19557 -12.37653 29.81269  1.000 27.52865  ? 204 VAL A C    1 
ATOM   2934 O O    . VAL A 1 204 ? -15.15137 -12.26334 30.46738  1.000 30.03962  ? 204 VAL A O    1 
ATOM   2935 C CB   . VAL A 1 204 ? -16.52149 -11.18327 27.60399  1.000 28.56706  ? 204 VAL A CB   1 
ATOM   2936 C CG1  . VAL A 1 204 ? -15.62783 -10.05364 28.10593  1.000 30.42310  ? 204 VAL A CG1  1 
ATOM   2937 C CG2  . VAL A 1 204 ? -16.40149 -11.32100 26.09511  1.000 28.89150  ? 204 VAL A CG2  1 
ATOM   2938 H H    . VAL A 1 204 ? -17.65032 -13.34645 27.29000  1.000 33.60801  ? 204 VAL A H    1 
ATOM   2939 H HA   . VAL A 1 204 ? -15.25347 -12.74185 28.03197  1.000 32.82582  ? 204 VAL A HA   1 
ATOM   2940 H HB   . VAL A 1 204 ? -17.44090 -10.96158 27.81948  1.000 35.01654  ? 204 VAL A HB   1 
ATOM   2941 H HG11 . VAL A 1 204 ? -15.69905 -9.30089  27.49832  1.000 37.24379  ? 204 VAL A HG11 1 
ATOM   2942 H HG12 . VAL A 1 204 ? -15.91891 -9.79121  28.99323  1.000 37.24379  ? 204 VAL A HG12 1 
ATOM   2943 H HG13 . VAL A 1 204 ? -14.71047 -10.36720 28.13800  1.000 37.24379  ? 204 VAL A HG13 1 
ATOM   2944 H HG21 . VAL A 1 204 ? -16.64084 -10.47715 25.68094  1.000 35.40587  ? 204 VAL A HG21 1 
ATOM   2945 H HG22 . VAL A 1 204 ? -15.48642 -11.55175 25.87084  1.000 35.40587  ? 204 VAL A HG22 1 
ATOM   2946 H HG23 . VAL A 1 204 ? -17.00241 -12.01994 25.79301  1.000 35.40587  ? 204 VAL A HG23 1 
ATOM   2947 N N    . LEU A 1 205 ? -17.39490 -12.41546 30.39961  1.000 27.53169  ? 205 LEU A N    1 
ATOM   2948 C CA   . LEU A 1 205 ? -17.50955 -12.30175 31.84967  1.000 29.01864  ? 205 LEU A CA   1 
ATOM   2949 C C    . LEU A 1 205 ? -16.83361 -13.47201 32.54917  1.000 29.40514  ? 205 LEU A C    1 
ATOM   2950 O O    . LEU A 1 205 ? -16.18623 -13.29947 33.58985  1.000 30.41973  ? 205 LEU A O    1 
ATOM   2951 C CB   . LEU A 1 205 ? -18.97843 -12.22583 32.25655  1.000 30.78665  ? 205 LEU A CB   1 
ATOM   2952 C CG   . LEU A 1 205 ? -19.73947 -11.01647 31.72304  1.000 34.13673  ? 205 LEU A CG   1 
ATOM   2953 C CD1  . LEU A 1 205 ? -21.23782 -11.21987 31.85718  1.000 35.34124  ? 205 LEU A CD1  1 
ATOM   2954 C CD2  . LEU A 1 205 ? -19.29631 -9.75928  32.45149  1.000 37.30535  ? 205 LEU A CD2  1 
ATOM   2955 H H    . LEU A 1 205 ? -18.14359 -12.50547 29.98614  1.000 33.77409  ? 205 LEU A H    1 
ATOM   2956 H HA   . LEU A 1 205 ? -17.07236 -11.48277 32.13080  1.000 35.55843  ? 205 LEU A HA   1 
ATOM   2957 H HB2  . LEU A 1 205 ? -19.42784 -13.02003 31.92766  1.000 37.68005  ? 205 LEU A HB2  1 
ATOM   2958 H HB3  . LEU A 1 205 ? -19.02585 -12.19480 33.22489  1.000 37.68005  ? 205 LEU A HB3  1 
ATOM   2959 H HG   . LEU A 1 205 ? -19.54356 -10.90650 30.77941  1.000 41.70015  ? 205 LEU A HG   1 
ATOM   2960 H HD11 . LEU A 1 205 ? -21.69044 -10.39268 31.62958  1.000 43.14556  ? 205 LEU A HD11 1 
ATOM   2961 H HD12 . LEU A 1 205 ? -21.51597 -11.92612 31.25325  1.000 43.14556  ? 205 LEU A HD12 1 
ATOM   2962 H HD13 . LEU A 1 205 ? -21.44218 -11.46774 32.77244  1.000 43.14556  ? 205 LEU A HD13 1 
ATOM   2963 H HD21 . LEU A 1 205 ? -19.79851 -9.00287  32.11010  1.000 45.50249  ? 205 LEU A HD21 1 
ATOM   2964 H HD22 . LEU A 1 205 ? -19.46583 -9.86776  33.40038  1.000 45.50249  ? 205 LEU A HD22 1 
ATOM   2965 H HD23 . LEU A 1 205 ? -18.34821 -9.62314  32.29829  1.000 45.50249  ? 205 LEU A HD23 1 
ATOM   2966 N N    . ALA A 1 206 ? -17.00360 -14.67924 32.01130  1.000 27.08051  ? 206 ALA A N    1 
ATOM   2967 C CA   . ALA A 1 206 ? -16.29465 -15.82901 32.55878  1.000 29.55089  ? 206 ALA A CA   1 
ATOM   2968 C C    . ALA A 1 206 ? -14.79407 -15.57362 32.57876  1.000 29.95007  ? 206 ALA A C    1 
ATOM   2969 O O    . ALA A 1 206 ? -14.11836 -15.84352 33.58084  1.000 31.96039  ? 206 ALA A O    1 
ATOM   2970 C CB   . ALA A 1 206 ? -16.62128 -17.07927 31.74089  1.000 29.43659  ? 206 ALA A CB   1 
ATOM   2971 H H    . ALA A 1 206 ? -17.51413 -14.85485 31.34188  1.000 33.23268  ? 206 ALA A H    1 
ATOM   2972 H HA   . ALA A 1 206 ? -16.58862 -15.98516 33.46988  1.000 36.19714  ? 206 ALA A HA   1 
ATOM   2973 H HB1  . ALA A 1 206 ? -16.12317 -17.83035 32.09961  1.000 36.05998  ? 206 ALA A HB1  1 
ATOM   2974 H HB2  . ALA A 1 206 ? -17.57334 -17.25535 31.79978  1.000 36.05998  ? 206 ALA A HB2  1 
ATOM   2975 H HB3  . ALA A 1 206 ? -16.36967 -16.92665 30.81661  1.000 36.05998  ? 206 ALA A HB3  1 
ATOM   2976 N N    . TRP A 1 207 ? -14.26547 -15.02834 31.47971  1.000 28.56206  ? 207 TRP A N    1 
ATOM   2977 C CA   . TRP A 1 207 ? -12.83451 -14.77683 31.33317  1.000 30.39923  ? 207 TRP A CA   1 
ATOM   2978 C C    . TRP A 1 207 ? -12.36286 -13.64918 32.23535  1.000 30.54447  ? 207 TRP A C    1 
ATOM   2979 O O    . TRP A 1 207 ? -11.21106 -13.66187 32.68240  1.000 31.18668  ? 207 TRP A O    1 
ATOM   2980 C CB   . TRP A 1 207 ? -12.55451 -14.48016 29.85775  1.000 30.48066  ? 207 TRP A CB   1 
ATOM   2981 C CG   . TRP A 1 207 ? -11.18028 -13.99921 29.50073  1.000 32.92205  ? 207 TRP A CG   1 
ATOM   2982 C CD1  . TRP A 1 207 ? -10.05584 -14.75816 29.34334  1.000 33.43100  ? 207 TRP A CD1  1 
ATOM   2983 C CD2  . TRP A 1 207 ? -10.79917 -12.65107 29.20221  1.000 32.78240  ? 207 TRP A CD2  1 
ATOM   2984 N NE1  . TRP A 1 207 ? -8.99485  -13.96267 28.98161  1.000 33.12542  ? 207 TRP A NE1  1 
ATOM   2985 C CE2  . TRP A 1 207 ? -9.42413  -12.66433 28.88987  1.000 34.88880  ? 207 TRP A CE2  1 
ATOM   2986 C CE3  . TRP A 1 207 ? -11.48611 -11.43248 29.17425  1.000 32.56148  ? 207 TRP A CE3  1 
ATOM   2987 C CZ2  . TRP A 1 207 ? -8.72268  -11.50602 28.55899  1.000 35.31178  ? 207 TRP A CZ2  1 
ATOM   2988 C CZ3  . TRP A 1 207 ? -10.78633 -10.28392 28.84500  1.000 35.06094  ? 207 TRP A CZ3  1 
ATOM   2989 C CH2  . TRP A 1 207 ? -9.42061  -10.33007 28.53990  1.000 34.71891  ? 207 TRP A CH2  1 
ATOM   2990 H H    . TRP A 1 207 ? -14.72379 -14.79079 30.79187  1.000 35.01054  ? 207 TRP A H    1 
ATOM   2991 H HA   . TRP A 1 207 ? -12.32353 -15.55963 31.59206  1.000 37.21514  ? 207 TRP A HA   1 
ATOM   2992 H HB2  . TRP A 1 207 ? -12.70517 -15.29647 29.35592  1.000 37.31286  ? 207 TRP A HB2  1 
ATOM   2993 H HB3  . TRP A 1 207 ? -13.17584 -13.79362 29.56878  1.000 37.31286  ? 207 TRP A HB3  1 
ATOM   2994 H HD1  . TRP A 1 207 ? -10.01406 -15.67942 29.46345  1.000 40.85327  ? 207 TRP A HD1  1 
ATOM   2995 H HE1  . TRP A 1 207 ? -8.19222  -14.23531 28.83647  1.000 40.48657  ? 207 TRP A HE1  1 
ATOM   2996 H HE3  . TRP A 1 207 ? -12.39391 -11.39471 29.37268  1.000 39.80984  ? 207 TRP A HE3  1 
ATOM   2997 H HZ2  . TRP A 1 207 ? -7.81484  -11.53193 28.35888  1.000 43.11020  ? 207 TRP A HZ2  1 
ATOM   2998 H HZ3  . TRP A 1 207 ? -11.23129 -9.46749  28.82619  1.000 42.80920  ? 207 TRP A HZ3  1 
ATOM   2999 H HH2  . TRP A 1 207 ? -8.97774  -9.54266  28.31911  1.000 42.39876  ? 207 TRP A HH2  1 
ATOM   3000 N N    . LEU A 1 208 ? -13.22623 -12.67420 32.51869  1.000 30.10506  ? 208 LEU A N    1 
ATOM   3001 C CA   . LEU A 1 208 ? -12.90149 -11.68342 33.54067  1.000 29.33535  ? 208 LEU A CA   1 
ATOM   3002 C C    . LEU A 1 208 ? -12.82886 -12.32699 34.92174  1.000 31.18317  ? 208 LEU A C    1 
ATOM   3003 O O    . LEU A 1 208 ? -11.94096 -11.99880 35.71860  1.000 34.23766  ? 208 LEU A O    1 
ATOM   3004 C CB   . LEU A 1 208 ? -13.92846 -10.55287 33.51121  1.000 29.65784  ? 208 LEU A CB   1 
ATOM   3005 C CG   . LEU A 1 208 ? -13.89377 -9.70953  32.23513  1.000 29.27507  ? 208 LEU A CG   1 
ATOM   3006 C CD1  . LEU A 1 208 ? -15.03402 -8.69994  32.20320  1.000 35.61187  ? 208 LEU A CD1  1 
ATOM   3007 C CD2  . LEU A 1 208 ? -12.55170 -8.99357  32.08631  1.000 33.14448  ? 208 LEU A CD2  1 
ATOM   3008 H H    . LEU A 1 208 ? -13.99138 -12.56626 32.14120  1.000 36.86214  ? 208 LEU A H    1 
ATOM   3009 H HA   . LEU A 1 208 ? -12.03270 -11.29688 33.34913  1.000 35.93849  ? 208 LEU A HA   1 
ATOM   3010 H HB2  . LEU A 1 208 ? -14.81547 -10.93815 33.58642  1.000 36.32548  ? 208 LEU A HB2  1 
ATOM   3011 H HB3  . LEU A 1 208 ? -13.75917 -9.96105  34.26088  1.000 36.32548  ? 208 LEU A HB3  1 
ATOM   3012 H HG   . LEU A 1 208 ? -14.00497 -10.30831 31.48015  1.000 35.86615  ? 208 LEU A HG   1 
ATOM   3013 H HD11 . LEU A 1 208 ? -15.04919 -8.26805  31.33479  1.000 43.47031  ? 208 LEU A HD11 1 
ATOM   3014 H HD12 . LEU A 1 208 ? -15.87161 -9.16461  32.35621  1.000 43.47031  ? 208 LEU A HD12 1 
ATOM   3015 H HD13 . LEU A 1 208 ? -14.89041 -8.03926  32.89874  1.000 43.47031  ? 208 LEU A HD13 1 
ATOM   3016 H HD21 . LEU A 1 208 ? -12.63761 -8.29772  31.41600  1.000 40.50944  ? 208 LEU A HD21 1 
ATOM   3017 H HD22 . LEU A 1 208 ? -12.30604 -8.60260  32.93936  1.000 40.50944  ? 208 LEU A HD22 1 
ATOM   3018 H HD23 . LEU A 1 208 ? -11.87953 -9.63658  31.81133  1.000 40.50944  ? 208 LEU A HD23 1 
ATOM   3019 N N    . TYR A 1 209 ? -13.74413 -13.25538 35.21933  1.000 30.40768  ? 209 TYR A N    1 
ATOM   3020 C CA   . TYR A 1 209 ? -13.64755 -14.01022 36.46491  1.000 33.35393  ? 209 TYR A CA   1 
ATOM   3021 C C    . TYR A 1 209 ? -12.37410 -14.84469 36.50173  1.000 34.04818  ? 209 TYR A C    1 
ATOM   3022 O O    . TYR A 1 209 ? -11.71601 -14.94754 37.54313  1.000 34.14660  ? 209 TYR A O    1 
ATOM   3023 C CB   . TYR A 1 209 ? -14.87216 -14.90835 36.63826  1.000 33.17346  ? 209 TYR A CB   1 
ATOM   3024 C CG   . TYR A 1 209 ? -16.07628 -14.19716 37.20516  1.000 34.02586  ? 209 TYR A CG   1 
ATOM   3025 C CD1  . TYR A 1 209 ? -16.08999 -13.76930 38.52402  1.000 36.13368  ? 209 TYR A CD1  1 
ATOM   3026 C CD2  . TYR A 1 209 ? -17.20015 -13.95821 36.42739  1.000 32.77738  ? 209 TYR A CD2  1 
ATOM   3027 C CE1  . TYR A 1 209 ? -17.18537 -13.11862 39.05270  1.000 40.37786  ? 209 TYR A CE1  1 
ATOM   3028 C CE2  . TYR A 1 209 ? -18.30293 -13.30712 36.94773  1.000 37.32076  ? 209 TYR A CE2  1 
ATOM   3029 C CZ   . TYR A 1 209 ? -18.29021 -12.89078 38.26182  1.000 39.63556  ? 209 TYR A CZ   1 
ATOM   3030 O OH   . TYR A 1 209 ? -19.38205 -12.24184 38.78994  1.000 40.89849  ? 209 TYR A OH   1 
ATOM   3031 H H    . TYR A 1 209 ? -14.41692 -13.46154 34.72490  1.000 37.22528  ? 209 TYR A H    1 
ATOM   3032 H HA   . TYR A 1 209 ? -13.62686 -13.38389 37.20530  1.000 40.76079  ? 209 TYR A HA   1 
ATOM   3033 H HB2  . TYR A 1 209 ? -15.12109 -15.26606 35.77167  1.000 40.54422  ? 209 TYR A HB2  1 
ATOM   3034 H HB3  . TYR A 1 209 ? -14.64452 -15.63189 37.24288  1.000 40.54422  ? 209 TYR A HB3  1 
ATOM   3035 H HD1  . TYR A 1 209 ? -15.34721 -13.92382 39.06189  1.000 44.09649  ? 209 TYR A HD1  1 
ATOM   3036 H HD2  . TYR A 1 209 ? -17.21172 -14.24073 35.54141  1.000 40.06892  ? 209 TYR A HD2  1 
ATOM   3037 H HE1  . TYR A 1 209 ? -17.17811 -12.83520 39.93843  1.000 49.18950  ? 209 TYR A HE1  1 
ATOM   3038 H HE2  . TYR A 1 209 ? -19.04878 -13.15093 36.41461  1.000 45.52098  ? 209 TYR A HE2  1 
ATOM   3039 H HH   . TYR A 1 209 ? -19.19592 -11.93913 39.55108  1.000 49.81426  ? 209 TYR A HH   1 
ATOM   3040 N N    . ALA A 1 210 ? -12.01874 -15.46308 35.37502  1.000 31.99809  ? 210 ALA A N    1 
ATOM   3041 C CA   . ALA A 1 210 ? -10.73992 -16.15776 35.29341  1.000 34.76520  ? 210 ALA A CA   1 
ATOM   3042 C C    . ALA A 1 210 ? -9.59534  -15.22229 35.66307  1.000 33.01927  ? 210 ALA A C    1 
ATOM   3043 O O    . ALA A 1 210 ? -8.68774  -15.59935 36.41360  1.000 36.71005  ? 210 ALA A O    1 
ATOM   3044 C CB   . ALA A 1 210 ? -10.53801 -16.72426 33.88575  1.000 33.10506  ? 210 ALA A CB   1 
ATOM   3045 H H    . ALA A 1 210 ? -12.49239 -15.49373 34.65786  1.000 39.13378  ? 210 ALA A H    1 
ATOM   3046 H HA   . ALA A 1 210 ? -10.74073 -16.90282 35.91453  1.000 42.45431  ? 210 ALA A HA   1 
ATOM   3047 H HB1  . ALA A 1 210 ? -9.69036  -17.19473 33.85325  1.000 40.46214  ? 210 ALA A HB1  1 
ATOM   3048 H HB2  . ALA A 1 210 ? -11.26361 -17.33567 33.68430  1.000 40.46214  ? 210 ALA A HB2  1 
ATOM   3049 H HB3  . ALA A 1 210 ? -10.53508 -15.99298 33.24846  1.000 40.46214  ? 210 ALA A HB3  1 
ATOM   3050 N N    . ALA A 1 211 ? -9.63814  -13.98383 35.16210  1.000 33.51415  ? 211 ALA A N    1 
ATOM   3051 C CA   . ALA A 1 211 ? -8.55344  -13.04061 35.41315  1.000 33.25417  ? 211 ALA A CA   1 
ATOM   3052 C C    . ALA A 1 211 ? -8.44950  -12.69542 36.89374  1.000 37.00865  ? 211 ALA A C    1 
ATOM   3053 O O    . ALA A 1 211 ? -7.34381  -12.54595 37.42726  1.000 38.63948  ? 211 ALA A O    1 
ATOM   3054 C CB   . ALA A 1 211 ? -8.75928  -11.77822 34.57497  1.000 33.55499  ? 211 ALA A CB   1 
ATOM   3055 H H    . ALA A 1 211 ? -10.27754 -13.67083 34.67959  1.000 40.95305  ? 211 ALA A H    1 
ATOM   3056 H HA   . ALA A 1 211 ? -7.71446  -13.44704 35.14516  1.000 40.64107  ? 211 ALA A HA   1 
ATOM   3057 H HB1  . ALA A 1 211 ? -8.07861  -11.12844 34.81028  1.000 41.00206  ? 211 ALA A HB1  1 
ATOM   3058 H HB2  . ALA A 1 211 ? -8.68672  -12.00774 33.63531  1.000 41.00206  ? 211 ALA A HB2  1 
ATOM   3059 H HB3  . ALA A 1 211 ? -9.64004  -11.41640 34.76004  1.000 41.00206  ? 211 ALA A HB3  1 
ATOM   3060 N N    . VAL A 1 212 ? -9.58952  -12.56560 37.57575  1.000 35.69461  ? 212 VAL A N    1 
ATOM   3061 C CA   . VAL A 1 212 ? -9.56563  -12.29065 39.00823  1.000 36.67221  ? 212 VAL A CA   1 
ATOM   3062 C C    . VAL A 1 212 ? -8.95460  -13.46339 39.76395  1.000 38.57831  ? 212 VAL A C    1 
ATOM   3063 O O    . VAL A 1 212 ? -8.12200  -13.27695 40.66064  1.000 38.63937  ? 212 VAL A O    1 
ATOM   3064 C CB   . VAL A 1 212 ? -10.98741 -11.97345 39.50779  1.000 37.92941  ? 212 VAL A CB   1 
ATOM   3065 C CG1  . VAL A 1 212 ? -10.99473 -11.73398 41.01470  1.000 37.96628  ? 212 VAL A CG1  1 
ATOM   3066 C CG2  . VAL A 1 212 ? -11.55540 -10.76945 38.76281  1.000 37.69741  ? 212 VAL A CG2  1 
ATOM   3067 H H    . VAL A 1 212 ? -10.37692 -12.63151 37.23625  1.000 43.56960  ? 212 VAL A H    1 
ATOM   3068 H HA   . VAL A 1 212 ? -9.00916  -11.51204 39.16642  1.000 44.74272  ? 212 VAL A HA   1 
ATOM   3069 H HB   . VAL A 1 212 ? -11.55836 -12.73704 39.32935  1.000 46.25135  ? 212 VAL A HB   1 
ATOM   3070 H HG11 . VAL A 1 212 ? -11.89512 -11.50521 41.29374  1.000 46.29560  ? 212 VAL A HG11 1 
ATOM   3071 H HG12 . VAL A 1 212 ? -10.70454 -12.54295 41.46443  1.000 46.29560  ? 212 VAL A HG12 1 
ATOM   3072 H HG13 . VAL A 1 212 ? -10.38908 -11.00509 41.22158  1.000 46.29560  ? 212 VAL A HG13 1 
ATOM   3073 H HG21 . VAL A 1 212 ? -12.45009 -10.58838 39.09090  1.000 45.97296  ? 212 VAL A HG21 1 
ATOM   3074 H HG22 . VAL A 1 212 ? -10.98359 -10.00196 38.92057  1.000 45.97296  ? 212 VAL A HG22 1 
ATOM   3075 H HG23 . VAL A 1 212 ? -11.58525 -10.97030 37.81430  1.000 45.97296  ? 212 VAL A HG23 1 
ATOM   3076 N N    . ILE A 1 213 ? -9.34867  -14.68823 39.40693  1.000 39.90850  ? 213 ILE A N    1 
ATOM   3077 C CA   . ILE A 1 213 ? -8.82156  -15.87055 40.07850  1.000 39.40208  ? 213 ILE A CA   1 
ATOM   3078 C C    . ILE A 1 213 ? -7.30713  -15.92960 39.96399  1.000 40.64884  ? 213 ILE A C    1 
ATOM   3079 O O    . ILE A 1 213 ? -6.63140  -16.47253 40.84837  1.000 41.66130  ? 213 ILE A O    1 
ATOM   3080 C CB   . ILE A 1 213 ? -9.48040  -17.14450 39.50450  1.000 40.54576  ? 213 ILE A CB   1 
ATOM   3081 C CG1  . ILE A 1 213 ? -10.97360 -17.16226 39.84698  1.000 40.72906  ? 213 ILE A CG1  1 
ATOM   3082 C CG2  . ILE A 1 213 ? -8.77133  -18.38772 40.02014  1.000 42.60938  ? 213 ILE A CG2  1 
ATOM   3083 C CD1  . ILE A 1 213 ? -11.75600 -18.29040 39.19978  1.000 44.14638  ? 213 ILE A CD1  1 
ATOM   3084 H H    . ILE A 1 213 ? -9.91600  -14.85815 38.78334  1.000 48.62626  ? 213 ILE A H    1 
ATOM   3085 H HA   . ILE A 1 213 ? -9.04445  -15.81269 41.02077  1.000 48.01857  ? 213 ILE A HA   1 
ATOM   3086 H HB   . ILE A 1 213 ? -9.39501  -17.13711 38.53829  1.000 49.39098  ? 213 ILE A HB   1 
ATOM   3087 H HG12 . ILE A 1 213 ? -11.06890 -17.25378 40.80794  1.000 49.61095  ? 213 ILE A HG12 1 
ATOM   3088 H HG13 . ILE A 1 213 ? -11.36785 -16.32630 39.55262  1.000 49.61095  ? 213 ILE A HG13 1 
ATOM   3089 H HG21 . ILE A 1 213 ? -9.36536  -19.14948 39.93209  1.000 51.86732  ? 213 ILE A HG21 1 
ATOM   3090 H HG22 . ILE A 1 213 ? -7.96759  -18.53280 39.49682  1.000 51.86732  ? 213 ILE A HG22 1 
ATOM   3091 H HG23 . ILE A 1 213 ? -8.53944  -18.25513 40.95264  1.000 51.86732  ? 213 ILE A HG23 1 
ATOM   3092 H HD11 . ILE A 1 213 ? -12.70446 -18.12640 39.31990  1.000 53.71173  ? 213 ILE A HD11 1 
ATOM   3093 H HD12 . ILE A 1 213 ? -11.54271 -18.32062 38.25401  1.000 53.71173  ? 213 ILE A HD12 1 
ATOM   3094 H HD13 . ILE A 1 213 ? -11.50919 -19.12835 39.62147  1.000 53.71173  ? 213 ILE A HD13 1 
ATOM   3095 N N    . ASN A 1 214 ? -6.74749  -15.36608 38.89360  1.000 39.57560  ? 214 ASN A N    1 
ATOM   3096 C CA   . ASN A 1 214 ? -5.32266  -15.45936 38.61376  1.000 42.78251  ? 214 ASN A CA   1 
ATOM   3097 C C    . ASN A 1 214 ? -4.55708  -14.18709 38.95211  1.000 43.18683  ? 214 ASN A C    1 
ATOM   3098 O O    . ASN A 1 214 ? -3.39145  -14.05659 38.56217  1.000 45.93633  ? 214 ASN A O    1 
ATOM   3099 C CB   . ASN A 1 214 ? -5.10355  -15.81721 37.14333  1.000 42.00079  ? 214 ASN A CB   1 
ATOM   3100 C CG   . ASN A 1 214 ? -5.19313  -17.30436 36.88995  1.000 44.56319  ? 214 ASN A CG   1 
ATOM   3101 O OD1  . ASN A 1 214 ? -4.19060  -18.01499 36.95068  1.000 45.50741  ? 214 ASN A OD1  1 
ATOM   3102 N ND2  . ASN A 1 214 ? -6.40016  -17.78837 36.61416  1.000 45.02956  ? 214 ASN A ND2  1 
ATOM   3103 H H    . ASN A 1 214 ? -7.18470  -14.91621 38.30533  1.000 48.22679  ? 214 ASN A H    1 
ATOM   3104 H HA   . ASN A 1 214 ? -4.95585  -16.17100 39.16141  1.000 52.07507  ? 214 ASN A HA   1 
ATOM   3105 H HB2  . ASN A 1 214 ? -5.78184  -15.37898 36.60595  1.000 51.13702  ? 214 ASN A HB2  1 
ATOM   3106 H HB3  . ASN A 1 214 ? -4.22140  -15.51837 36.87240  1.000 51.13702  ? 214 ASN A HB3  1 
ATOM   3107 H HD21 . ASN A 1 214 ? -6.50212  -18.62874 36.46256  1.000 54.77154  ? 214 ASN A HD21 1 
ATOM   3108 H HD22 . ASN A 1 214 ? -7.07905  -17.26112 36.58736  1.000 54.77154  ? 214 ASN A HD22 1 
ATOM   3109 N N    . GLY A 1 215 ? -5.17981  -13.24820 39.66035  1.000 44.19544  ? 215 GLY A N    1 
ATOM   3110 C CA   . GLY A 1 215 ? -4.48305  -12.09794 40.18924  1.000 44.34832  ? 215 GLY A CA   1 
ATOM   3111 C C    . GLY A 1 215 ? -4.70014  -10.79941 39.44544  1.000 44.98695  ? 215 GLY A C    1 
ATOM   3112 O O    . GLY A 1 215 ? -4.27945  -9.74800  39.94417  1.000 46.12031  ? 215 GLY A O    1 
ATOM   3113 H H    . GLY A 1 215 ? -6.01928  -13.26254 39.84658  1.000 53.77060  ? 215 GLY A H    1 
ATOM   3114 H HA2  . GLY A 1 215 ? -4.76872  -11.96053 41.10598  1.000 53.95405  ? 215 GLY A HA2  1 
ATOM   3115 H HA3  . GLY A 1 215 ? -3.53115  -12.28424 40.17964  1.000 53.95405  ? 215 GLY A HA3  1 
ATOM   3116 N N    . ASP A 1 216 ? -5.32693  -10.83275 38.27385  1.000 44.67065  ? 216 ASP A N    1 
ATOM   3117 C CA   . ASP A 1 216 ? -5.58887  -9.62192  37.50268  1.000 43.72762  ? 216 ASP A CA   1 
ATOM   3118 C C    . ASP A 1 216 ? -6.89765  -9.01068  37.99062  1.000 47.03629  ? 216 ASP A C    1 
ATOM   3119 O O    . ASP A 1 216 ? -7.97469  -9.58035  37.78148  1.000 46.11516  ? 216 ASP A O    1 
ATOM   3120 C CB   . ASP A 1 216 ? -5.64377  -9.92829  36.00950  1.000 43.87911  ? 216 ASP A CB   1 
ATOM   3121 C CG   . ASP A 1 216 ? -4.26969  -9.96935  35.37579  1.000 46.88547  ? 216 ASP A CG   1 
ATOM   3122 O OD1  . ASP A 1 216 ? -3.26809  -9.86037  36.11623  1.000 49.40989  ? 216 ASP A OD1  1 
ATOM   3123 O OD2  . ASP A 1 216 ? -4.18984  -10.10479 34.13514  1.000 45.77490  ? 216 ASP A OD2  1 
ATOM   3124 H H    . ASP A 1 216 ? -5.61336  -11.55255 37.90041  1.000 54.34085  ? 216 ASP A H    1 
ATOM   3125 H HA   . ASP A 1 216 ? -4.87383  -8.98375  37.65223  1.000 53.20921  ? 216 ASP A HA   1 
ATOM   3126 H HB2  . ASP A 1 216 ? -6.06166  -10.79381 35.87853  1.000 53.39100  ? 216 ASP A HB2  1 
ATOM   3127 H HB3  . ASP A 1 216 ? -6.16064  -9.23939  35.56323  1.000 53.39100  ? 216 ASP A HB3  1 
ATOM   3128 N N    . ARG A 1 217 ? -6.80229  -7.84748  38.63913  1.000 44.95114  ? 217 ARG A N    1 
ATOM   3129 C CA   . ARG A 1 217 ? -7.95684  -7.19150  39.23164  1.000 46.40282  ? 217 ARG A CA   1 
ATOM   3130 C C    . ARG A 1 217 ? -8.11149  -5.73429  38.81246  1.000 46.12248  ? 217 ARG A C    1 
ATOM   3131 O O    . ARG A 1 217 ? -9.06823  -5.08437  39.24799  1.000 46.89170  ? 217 ARG A O    1 
ATOM   3132 C CB   . ARG A 1 217 ? -7.87326  -7.25997  40.76872  1.000 51.44666  ? 217 ARG A CB   1 
ATOM   3133 C CG   . ARG A 1 217 ? -7.87314  -8.67004  41.35272  1.000 50.09868  ? 217 ARG A CG   1 
ATOM   3134 C CD   . ARG A 1 217 ? -7.50459  -8.67189  42.84189  1.000 56.77975  ? 217 ARG A CD   1 
ATOM   3135 N NE   . ARG A 1 217 ? -6.10170  -8.33866  43.06896  1.000 56.95281  ? 217 ARG A NE   1 
ATOM   3136 C CZ   . ARG A 1 217 ? -5.65883  -7.14652  43.44824  1.000 55.94913  ? 217 ARG A CZ   1 
ATOM   3137 N NH1  . ARG A 1 217 ? -6.48860  -6.14448  43.68754  1.000 58.63864  ? 217 ARG A NH1  1 
ATOM   3138 N NH2  . ARG A 1 217 ? -4.34979  -6.95669  43.59134  1.000 53.56195  ? 217 ARG A NH2  1 
ATOM   3139 H H    . ARG A 1 217 ? -6.06635  -7.41607  38.74815  1.000 54.67743  ? 217 ARG A H    1 
ATOM   3140 H HA   . ARG A 1 217 ? -8.75538  -7.66441  38.94950  1.000 56.41945  ? 217 ARG A HA   1 
ATOM   3141 H HB2  . ARG A 1 217 ? -7.05176  -6.82827  41.05097  1.000 62.47206  ? 217 ARG A HB2  1 
ATOM   3142 H HB3  . ARG A 1 217 ? -8.63807  -6.79201  41.13884  1.000 62.47206  ? 217 ARG A HB3  1 
ATOM   3143 H HG2  . ARG A 1 217 ? -8.75845  -9.05518  41.25893  1.000 60.85448  ? 217 ARG A HG2  1 
ATOM   3144 H HG3  . ARG A 1 217 ? -7.22346  -9.21247  40.87883  1.000 60.85448  ? 217 ARG A HG3  1 
ATOM   3145 H HD2  . ARG A 1 217 ? -8.04869  -8.01548  43.30447  1.000 68.87177  ? 217 ARG A HD2  1 
ATOM   3146 H HD3  . ARG A 1 217 ? -7.66737  -9.55520  43.20818  1.000 68.87177  ? 217 ARG A HD3  1 
ATOM   3147 H HE   . ARG A 1 217 ? -5.51973  -8.96020  42.94814  1.000 69.07944  ? 217 ARG A HE   1 
ATOM   3148 H HH11 . ARG A 1 217 ? -7.33644  -6.25758  43.59826  1.000 71.10243  ? 217 ARG A HH11 1 
ATOM   3149 H HH12 . ARG A 1 217 ? -6.18021  -5.37992  43.93240  1.000 71.10243  ? 217 ARG A HH12 1 
ATOM   3150 H HH21 . ARG A 1 217 ? -3.80245  -7.60219  43.43854  1.000 65.01041  ? 217 ARG A HH21 1 
ATOM   3151 H HH22 . ARG A 1 217 ? -4.05097  -6.18849  43.83665  1.000 65.01041  ? 217 ARG A HH22 1 
ATOM   3152 N N    . TRP A 1 218 ? -7.22158  -5.20911  37.96692  1.000 45.45145  ? 218 TRP A N    1 
ATOM   3153 C CA   . TRP A 1 218 ? -7.18617  -3.77119  37.72312  1.000 45.11398  ? 218 TRP A CA   1 
ATOM   3154 C C    . TRP A 1 218 ? -8.45135  -3.23649  37.06178  1.000 45.17629  ? 218 TRP A C    1 
ATOM   3155 O O    . TRP A 1 218 ? -8.61790  -2.01243  36.99098  1.000 46.22313  ? 218 TRP A O    1 
ATOM   3156 C CB   . TRP A 1 218 ? -5.96897  -3.40890  36.85939  1.000 45.23208  ? 218 TRP A CB   1 
ATOM   3157 C CG   . TRP A 1 218 ? -5.99007  -3.95157  35.45365  1.000 45.80004  ? 218 TRP A CG   1 
ATOM   3158 C CD1  . TRP A 1 218 ? -5.32902  -5.05298  34.98970  1.000 46.23268  ? 218 TRP A CD1  1 
ATOM   3159 C CD2  . TRP A 1 218 ? -6.69101  -3.40438  34.32801  1.000 46.79002  ? 218 TRP A CD2  1 
ATOM   3160 N NE1  . TRP A 1 218 ? -5.57803  -5.22759  33.64885  1.000 45.87766  ? 218 TRP A NE1  1 
ATOM   3161 C CE2  . TRP A 1 218 ? -6.41240  -4.22966  33.21973  1.000 47.48605  ? 218 TRP A CE2  1 
ATOM   3162 C CE3  . TRP A 1 218 ? -7.52832  -2.29939  34.15119  1.000 46.36043  ? 218 TRP A CE3  1 
ATOM   3163 C CZ2  . TRP A 1 218 ? -6.94280  -3.98573  31.95635  1.000 48.40410  ? 218 TRP A CZ2  1 
ATOM   3164 C CZ3  . TRP A 1 218 ? -8.05566  -2.06012  32.89573  1.000 48.82259  ? 218 TRP A CZ3  1 
ATOM   3165 C CH2  . TRP A 1 218 ? -7.76035  -2.89875  31.81480  1.000 52.33907  ? 218 TRP A CH2  1 
ATOM   3166 H H    . TRP A 1 218 ? -6.63557  -5.66062  37.52837  1.000 55.27781  ? 218 TRP A H    1 
ATOM   3167 H HA   . TRP A 1 218 ? -7.09438  -3.32879  38.58146  1.000 54.87285  ? 218 TRP A HA   1 
ATOM   3168 H HB2  . TRP A 1 218 ? -5.91637  -2.44244  36.79538  1.000 55.01457  ? 218 TRP A HB2  1 
ATOM   3169 H HB3  . TRP A 1 218 ? -5.17317  -3.75656  37.29153  1.000 55.01457  ? 218 TRP A HB3  1 
ATOM   3170 H HD1  . TRP A 1 218 ? -4.78815  -5.60550  35.50651  1.000 56.21529  ? 218 TRP A HD1  1 
ATOM   3171 H HE1  . TRP A 1 218 ? -5.26160  -5.86006  33.15951  1.000 55.78926  ? 218 TRP A HE1  1 
ATOM   3172 H HE3  . TRP A 1 218 ? -7.72688  -1.73611  34.86406  1.000 56.36859  ? 218 TRP A HE3  1 
ATOM   3173 H HZ2  . TRP A 1 218 ? -6.74862  -4.54081  31.23588  1.000 58.82098  ? 218 TRP A HZ2  1 
ATOM   3174 H HZ3  . TRP A 1 218 ? -8.61629  -1.32930  32.76726  1.000 59.32318  ? 218 TRP A HZ3  1 
ATOM   3175 H HH2  . TRP A 1 218 ? -8.12851  -2.71252  30.98132  1.000 63.54295  ? 218 TRP A HH2  1 
ATOM   3176 N N    . PHE A 1 219 ? -9.34404  -4.10474  36.58316  1.000 44.73177  ? 219 PHE A N    1 
ATOM   3177 C CA   . PHE A 1 219 ? -10.58323 -3.67585  35.94817  1.000 46.08950  ? 219 PHE A CA   1 
ATOM   3178 C C    . PHE A 1 219 ? -11.78457 -3.71666  36.88551  1.000 44.15543  ? 219 PHE A C    1 
ATOM   3179 O O    . PHE A 1 219 ? -12.86762 -3.26748  36.49610  1.000 46.33691  ? 219 PHE A O    1 
ATOM   3180 C CB   . PHE A 1 219 ? -10.87598 -4.55447  34.72359  1.000 44.69701  ? 219 PHE A CB   1 
ATOM   3181 C CG   . PHE A 1 219 ? -10.81634 -6.02163  35.02024  1.000 40.92985  ? 219 PHE A CG   1 
ATOM   3182 C CD1  . PHE A 1 219 ? -11.93130 -6.69333  35.48736  1.000 41.26090  ? 219 PHE A CD1  1 
ATOM   3183 C CD2  . PHE A 1 219 ? -9.63459  -6.72431  34.85686  1.000 40.47612  ? 219 PHE A CD2  1 
ATOM   3184 C CE1  . PHE A 1 219 ? -11.87255 -8.04006  35.77584  1.000 37.85922  ? 219 PHE A CE1  1 
ATOM   3185 C CE2  . PHE A 1 219 ? -9.56938  -8.07064  35.14536  1.000 40.05987  ? 219 PHE A CE2  1 
ATOM   3186 C CZ   . PHE A 1 219 ? -10.68984 -8.72885  35.60631  1.000 38.65224  ? 219 PHE A CZ   1 
ATOM   3187 H H    . PHE A 1 219 ? -9.25010  -4.95894  36.61651  1.000 54.41420  ? 219 PHE A H    1 
ATOM   3188 H HA   . PHE A 1 219 ? -10.47416 -2.76048  35.64634  1.000 56.04347  ? 219 PHE A HA   1 
ATOM   3189 H HB2  . PHE A 1 219 ? -11.76700 -4.35209  34.39797  1.000 54.37248  ? 219 PHE A HB2  1 
ATOM   3190 H HB3  . PHE A 1 219 ? -10.21976 -4.36248  34.03554  1.000 54.37248  ? 219 PHE A HB3  1 
ATOM   3191 H HD1  . PHE A 1 219 ? -12.72941 -6.23146  35.60818  1.000 50.24915  ? 219 PHE A HD1  1 
ATOM   3192 H HD2  . PHE A 1 219 ? -8.87613  -6.28291  34.54894  1.000 49.30742  ? 219 PHE A HD2  1 
ATOM   3193 H HE1  . PHE A 1 219 ? -12.62951 -8.48357  36.08440  1.000 46.16713  ? 219 PHE A HE1  1 
ATOM   3194 H HE2  . PHE A 1 219 ? -8.77142  -8.53400  35.02936  1.000 48.80792  ? 219 PHE A HE2  1 
ATOM   3195 H HZ   . PHE A 1 219 ? -10.64805 -9.63689  35.80280  1.000 47.11875  ? 219 PHE A HZ   1 
ATOM   3196 N N    . LEU A 1 220 ? -11.63073 -4.24889  38.09565  1.000 46.41701  ? 220 LEU A N    1 
ATOM   3197 C CA   . LEU A 1 220 ? -12.74044 -4.29043  39.04116  1.000 51.13421  ? 220 LEU A CA   1 
ATOM   3198 C C    . LEU A 1 220 ? -13.04828 -2.88098  39.53238  1.000 54.29353  ? 220 LEU A C    1 
ATOM   3199 O O    . LEU A 1 220 ? -12.14382 -2.14073  39.93210  1.000 52.51517  ? 220 LEU A O    1 
ATOM   3200 C CB   . LEU A 1 220 ? -12.40129 -5.21298  40.20788  1.000 50.82384  ? 220 LEU A CB   1 
ATOM   3201 C CG   . LEU A 1 220 ? -12.12330 -6.66498  39.80979  1.000 48.60672  ? 220 LEU A CG   1 
ATOM   3202 C CD1  . LEU A 1 220 ? -11.69983 -7.49939  41.00699  1.000 51.87025  ? 220 LEU A CD1  1 
ATOM   3203 C CD2  . LEU A 1 220 ? -13.34842 -7.27972  39.13755  1.000 47.38673  ? 220 LEU A CD2  1 
ATOM   3204 H H    . LEU A 1 220 ? -10.89873 -4.59018  38.39110  1.000 56.43648  ? 220 LEU A H    1 
ATOM   3205 H HA   . LEU A 1 220 ? -13.53420 -4.64203  38.60847  1.000 62.09712  ? 220 LEU A HA   1 
ATOM   3206 H HB2  . LEU A 1 220 ? -11.60749 -4.87252  40.64932  1.000 61.72467  ? 220 LEU A HB2  1 
ATOM   3207 H HB3  . LEU A 1 220 ? -13.14900 -5.21603  40.82579  1.000 61.72467  ? 220 LEU A HB3  1 
ATOM   3208 H HG   . LEU A 1 220 ? -11.38892 -6.67145  39.17611  1.000 59.06413  ? 220 LEU A HG   1 
ATOM   3209 H HD11 . LEU A 1 220 ? -11.32541 -8.33683  40.69170  1.000 62.98037  ? 220 LEU A HD11 1 
ATOM   3210 H HD12 . LEU A 1 220 ? -11.03367 -7.00922  41.51381  1.000 62.98037  ? 220 LEU A HD12 1 
ATOM   3211 H HD13 . LEU A 1 220 ? -12.47638 -7.67237  41.56192  1.000 62.98037  ? 220 LEU A HD13 1 
ATOM   3212 H HD21 . LEU A 1 220 ? -13.23565 -8.24221  39.09501  1.000 57.60015  ? 220 LEU A HD21 1 
ATOM   3213 H HD22 . LEU A 1 220 ? -14.13713 -7.06179  39.65846  1.000 57.60015  ? 220 LEU A HD22 1 
ATOM   3214 H HD23 . LEU A 1 220 ? -13.43275 -6.91666  38.24202  1.000 57.60015  ? 220 LEU A HD23 1 
ATOM   3215 N N    . ASN A 1 221 ? -14.32322 -2.50548  39.48795  1.000 57.70147  ? 221 ASN A N    1 
ATOM   3216 C CA   . ASN A 1 221 ? -14.74726 -1.14906  39.79388  1.000 63.19202  ? 221 ASN A CA   1 
ATOM   3217 C C    . ASN A 1 221 ? -15.73701 -1.14849  40.95136  1.000 67.17429  ? 221 ASN A C    1 
ATOM   3218 O O    . ASN A 1 221 ? -16.26292 -2.18685  41.35844  1.000 68.97575  ? 221 ASN A O    1 
ATOM   3219 C CB   . ASN A 1 221 ? -15.37889 -0.47546  38.56530  1.000 72.15277  ? 221 ASN A CB   1 
ATOM   3220 C CG   . ASN A 1 221 ? -16.68298 -1.13463  38.13460  1.000 63.36245  ? 221 ASN A CG   1 
ATOM   3221 O OD1  . ASN A 1 221 ? -17.20551 -2.02121  38.81287  1.000 63.92849  ? 221 ASN A OD1  1 
ATOM   3222 N ND2  . ASN A 1 221 ? -17.21944 -0.69292  37.00271  1.000 61.61775  ? 221 ASN A ND2  1 
ATOM   3223 H H    . ASN A 1 221 ? -14.97080 -3.03130  39.27877  1.000 69.97783  ? 221 ASN A H    1 
ATOM   3224 H HA   . ASN A 1 221 ? -13.96957 -0.63579  40.06344  1.000 76.56649  ? 221 ASN A HA   1 
ATOM   3225 H HB2  . ASN A 1 221 ? -15.56752 0.45240   38.77597  1.000 87.31939  ? 221 ASN A HB2  1 
ATOM   3226 H HB3  . ASN A 1 221 ? -14.75739 -0.52725  37.82236  1.000 87.31939  ? 221 ASN A HB3  1 
ATOM   3227 H HD21 . ASN A 1 221 ? -17.95564 -1.03167  36.71486  1.000 74.67737  ? 221 ASN A HD21 1 
ATOM   3228 H HD22 . ASN A 1 221 ? -16.83059 -0.06817  36.55765  1.000 74.67737  ? 221 ASN A HD22 1 
ATOM   3229 N N    . ARG A 1 222 ? -15.98905 0.04939   41.48054  1.000 73.20733  ? 222 ARG A N    1 
ATOM   3230 C CA   . ARG A 1 222 ? -17.00363 0.20663   42.51391  1.000 74.73933  ? 222 ARG A CA   1 
ATOM   3231 C C    . ARG A 1 222 ? -18.40714 0.20816   41.92583  1.000 72.51334  ? 222 ARG A C    1 
ATOM   3232 O O    . ARG A 1 222 ? -19.34473 -0.27054  42.57549  1.000 69.84514  ? 222 ARG A O    1 
ATOM   3233 C CB   . ARG A 1 222 ? -16.76401 1.50037   43.29650  1.000 76.50448  ? 222 ARG A CB   1 
ATOM   3234 H H    . ARG A 1 222 ? -15.58924 0.77791   41.25918  1.000 88.58486  ? 222 ARG A H    1 
ATOM   3235 H HA   . ARG A 1 222 ? -16.93497 -0.53388  43.13668  1.000 90.42326  ? 222 ARG A HA   1 
ATOM   3236 N N    . PHE A 1 223 ? -18.56843 0.72809   40.70945  1.000 72.52846  ? 223 PHE A N    1 
ATOM   3237 C CA   . PHE A 1 223 ? -19.89393 0.85293   40.13294  1.000 71.69281  ? 223 PHE A CA   1 
ATOM   3238 C C    . PHE A 1 223 ? -20.58265 -0.50834  40.06658  1.000 74.14739  ? 223 PHE A C    1 
ATOM   3239 O O    . PHE A 1 223 ? -19.95622 -1.56576  40.17672  1.000 67.69441  ? 223 PHE A O    1 
ATOM   3240 C CB   . PHE A 1 223 ? -19.82976 1.45040   38.72570  1.000 75.22675  ? 223 PHE A CB   1 
ATOM   3241 C CG   . PHE A 1 223 ? -18.88463 2.60458   38.59606  1.000 74.97694  ? 223 PHE A CG   1 
ATOM   3242 C CD1  . PHE A 1 223 ? -19.01926 3.72397   39.39872  1.000 76.13177  ? 223 PHE A CD1  1 
ATOM   3243 C CD2  . PHE A 1 223 ? -17.86072 2.57136   37.66521  1.000 77.24922  ? 223 PHE A CD2  1 
ATOM   3244 C CE1  . PHE A 1 223 ? -18.14430 4.78596   39.27983  1.000 83.53109  ? 223 PHE A CE1  1 
ATOM   3245 C CE2  . PHE A 1 223 ? -16.98515 3.62934   37.53963  1.000 80.80581  ? 223 PHE A CE2  1 
ATOM   3246 C CZ   . PHE A 1 223 ? -17.12657 4.73838   38.34706  1.000 83.42360  ? 223 PHE A CZ   1 
ATOM   3247 H H    . PHE A 1 223 ? -17.93044 1.01140   40.20715  1.000 87.77022  ? 223 PHE A H    1 
ATOM   3248 H HA   . PHE A 1 223 ? -20.41898 1.44613   40.69270  1.000 86.76744  ? 223 PHE A HA   1 
ATOM   3249 H HB2  . PHE A 1 223 ? -19.53971 0.76090   38.10816  1.000 91.00817  ? 223 PHE A HB2  1 
ATOM   3250 H HB3  . PHE A 1 223 ? -20.71419 1.76450   38.48070  1.000 91.00817  ? 223 PHE A HB3  1 
ATOM   3251 H HD1  . PHE A 1 223 ? -19.70606 3.76146   40.02467  1.000 92.09419  ? 223 PHE A HD1  1 
ATOM   3252 H HD2  . PHE A 1 223 ? -17.76202 1.82619   37.11759  1.000 93.43513  ? 223 PHE A HD2  1 
ATOM   3253 H HE1  . PHE A 1 223 ? -18.24018 5.53190   39.82689  1.000 100.97338 ? 223 PHE A HE1  1 
ATOM   3254 H HE2  . PHE A 1 223 ? -16.30031 3.59499   36.91137  1.000 97.70305  ? 223 PHE A HE2  1 
ATOM   3255 H HZ   . PHE A 1 223 ? -16.53757 5.45324   38.26367  1.000 100.84439 ? 223 PHE A HZ   1 
ATOM   3256 N N    . THR A 1 224 ? -21.90142 -0.46390  39.90616  1.000 69.85892  ? 224 THR A N    1 
ATOM   3257 C CA   . THR A 1 224 ? -22.68460 -1.63113  39.52288  1.000 63.65614  ? 224 THR A CA   1 
ATOM   3258 C C    . THR A 1 224 ? -23.54721 -1.20774  38.33736  1.000 63.00004  ? 224 THR A C    1 
ATOM   3259 O O    . THR A 1 224 ? -23.41231 -0.08566  37.83377  1.000 71.02293  ? 224 THR A O    1 
ATOM   3260 C CB   . THR A 1 224 ? -23.53833 -2.14726  40.67343  1.000 61.61037  ? 224 THR A CB   1 
ATOM   3261 O OG1  . THR A 1 224 ? -23.98970 -3.47299  40.36665  1.000 60.80524  ? 224 THR A OG1  1 
ATOM   3262 C CG2  . THR A 1 224 ? -24.73484 -1.24703  40.90321  1.000 62.84053  ? 224 THR A CG2  1 
ATOM   3263 H H    . THR A 1 224 ? -22.37528 0.24535   40.01580  1.000 84.56678  ? 224 THR A H    1 
ATOM   3264 H HA   . THR A 1 224 ? -22.10988 -2.37483  39.28306  1.000 77.12343  ? 224 THR A HA   1 
ATOM   3265 H HB   . THR A 1 224 ? -23.01265 -2.15971  41.48854  1.000 74.66851  ? 224 THR A HB   1 
ATOM   3266 H HG1  . THR A 1 224 ? -23.34896 -4.01374  40.41813  1.000 73.70236  ? 224 THR A HG1  1 
ATOM   3267 H HG21 . THR A 1 224 ? -25.06478 -1.35837  41.80855  1.000 76.14470  ? 224 THR A HG21 1 
ATOM   3268 H HG22 . THR A 1 224 ? -24.48238 -0.31970  40.77198  1.000 76.14470  ? 224 THR A HG22 1 
ATOM   3269 H HG23 . THR A 1 224 ? -25.44348 -1.47157  40.28006  1.000 76.14470  ? 224 THR A HG23 1 
ATOM   3270 N N    . THR A 1 225 ? -24.44497 -2.07999  37.89725  1.000 61.09785  ? 225 THR A N    1 
ATOM   3271 C CA   . THR A 1 225 ? -25.31206 -1.77026  36.77132  1.000 61.79266  ? 225 THR A CA   1 
ATOM   3272 C C    . THR A 1 225 ? -26.53348 -2.67170  36.85253  1.000 60.65505  ? 225 THR A C    1 
ATOM   3273 O O    . THR A 1 225 ? -26.59851 -3.59249  37.67024  1.000 59.78091  ? 225 THR A O    1 
ATOM   3274 C CB   . THR A 1 225 ? -24.58573 -1.95627  35.43457  1.000 60.58906  ? 225 THR A CB   1 
ATOM   3275 O OG1  . THR A 1 225 ? -25.43313 -1.52398  34.36271  1.000 62.43871  ? 225 THR A OG1  1 
ATOM   3276 C CG2  . THR A 1 225 ? -24.21116 -3.42034  35.22595  1.000 58.16516  ? 225 THR A CG2  1 
ATOM   3277 H H    . THR A 1 225 ? -24.57116 -2.86050  38.23560  1.000 74.05349  ? 225 THR A H    1 
ATOM   3278 H HA   . THR A 1 225 ? -25.60095 -0.84640  36.83389  1.000 74.88727  ? 225 THR A HA   1 
ATOM   3279 H HB   . THR A 1 225 ? -23.77069 -1.43033  35.43405  1.000 73.44295  ? 225 THR A HB   1 
ATOM   3280 H HG1  . THR A 1 225 ? -25.16765 -1.85201  33.63640  1.000 75.66252  ? 225 THR A HG1  1 
ATOM   3281 H HG21 . THR A 1 225 ? -23.56920 -3.49878  34.50302  1.000 70.53426  ? 225 THR A HG21 1 
ATOM   3282 H HG22 . THR A 1 225 ? -23.81839 -3.78101  36.03623  1.000 70.53426  ? 225 THR A HG22 1 
ATOM   3283 H HG23 . THR A 1 225 ? -25.00150 -3.93640  35.00250  1.000 70.53426  ? 225 THR A HG23 1 
ATOM   3284 N N    . THR A 1 226 ? -27.50430 -2.39019  35.99420  1.000 62.78206  ? 226 THR A N    1 
ATOM   3285 C CA   . THR A 1 226 ? -28.67432 -3.23690  35.83850  1.000 63.43338  ? 226 THR A CA   1 
ATOM   3286 C C    . THR A 1 226 ? -28.51287 -4.08626  34.58392  1.000 61.67786  ? 226 THR A C    1 
ATOM   3287 O O    . THR A 1 226 ? -27.87372 -3.67446  33.61209  1.000 61.37030  ? 226 THR A O    1 
ATOM   3288 C CB   . THR A 1 226 ? -29.95390 -2.40703  35.74616  1.000 66.88112  ? 226 THR A CB   1 
ATOM   3289 O OG1  . THR A 1 226 ? -29.96346 -1.66540  34.52247  1.000 64.10478  ? 226 THR A OG1  1 
ATOM   3290 C CG2  . THR A 1 226 ? -30.04843 -1.44236  36.92073  1.000 69.79661  ? 226 THR A CG2  1 
ATOM   3291 H H    . THR A 1 226 ? -27.50648 -1.69990  35.48128  1.000 76.07454  ? 226 THR A H    1 
ATOM   3292 H HA   . THR A 1 226 ? -28.76349 -3.82018  36.60840  1.000 76.85612  ? 226 THR A HA   1 
ATOM   3293 H HB   . THR A 1 226 ? -30.72305 -2.99760  35.76940  1.000 80.99341  ? 226 THR A HB   1 
ATOM   3294 H HG1  . THR A 1 226 ? -30.64674 -1.17807  34.48721  1.000 77.66180  ? 226 THR A HG1  1 
ATOM   3295 H HG21 . THR A 1 226 ? -30.95506 -1.10743  37.00282  1.000 84.49200  ? 226 THR A HG21 1 
ATOM   3296 H HG22 . THR A 1 226 ? -29.80470 -1.89578  37.74287  1.000 84.49200  ? 226 THR A HG22 1 
ATOM   3297 H HG23 . THR A 1 226 ? -29.44732 -0.69343  36.78416  1.000 84.49200  ? 226 THR A HG23 1 
ATOM   3298 N N    . LEU A 1 227 ? -29.08778 -5.28877  34.62011  1.000 60.26328  ? 227 LEU A N    1 
ATOM   3299 C CA   . LEU A 1 227 ? -29.05249 -6.15602  33.44803  1.000 60.39916  ? 227 LEU A CA   1 
ATOM   3300 C C    . LEU A 1 227 ? -29.61009 -5.43901  32.22534  1.000 60.55042  ? 227 LEU A C    1 
ATOM   3301 O O    . LEU A 1 227 ? -29.11986 -5.62552  31.10643  1.000 59.32936  ? 227 LEU A O    1 
ATOM   3302 C CB   . LEU A 1 227 ? -29.83923 -7.43330  33.72989  1.000 64.57586  ? 227 LEU A CB   1 
ATOM   3303 C CG   . LEU A 1 227 ? -29.66802 -8.57630  32.73182  1.000 55.51072  ? 227 LEU A CG   1 
ATOM   3304 C CD1  . LEU A 1 227 ? -28.20942 -8.97538  32.61151  1.000 53.15881  ? 227 LEU A CD1  1 
ATOM   3305 C CD2  . LEU A 1 227 ? -30.51824 -9.76524  33.15423  1.000 52.98275  ? 227 LEU A CD2  1 
ATOM   3306 H H    . LEU A 1 227 ? -29.49748 -5.61946  35.30010  1.000 73.05200  ? 227 LEU A H    1 
ATOM   3307 H HA   . LEU A 1 227 ? -28.13434 -6.40492  33.25844  1.000 73.21506  ? 227 LEU A HA   1 
ATOM   3308 H HB2  . LEU A 1 227 ? -29.56471 -7.76947  34.59737  1.000 78.22710  ? 227 LEU A HB2  1 
ATOM   3309 H HB3  . LEU A 1 227 ? -30.78247 -7.20752  33.74492  1.000 78.22710  ? 227 LEU A HB3  1 
ATOM   3310 H HG   . LEU A 1 227 ? -29.96329 -8.28210  31.85594  1.000 67.34893  ? 227 LEU A HG   1 
ATOM   3311 H HD11 . LEU A 1 227 ? -28.15486 -9.85290  32.20178  1.000 64.52665  ? 227 LEU A HD11 1 
ATOM   3312 H HD12 . LEU A 1 227 ? -27.74815 -8.32380  32.06054  1.000 64.52665  ? 227 LEU A HD12 1 
ATOM   3313 H HD13 . LEU A 1 227 ? -27.81431 -8.99868  33.49709  1.000 64.52665  ? 227 LEU A HD13 1 
ATOM   3314 H HD21 . LEU A 1 227 ? -30.41745 -10.47399 32.49969  1.000 64.31537  ? 227 LEU A HD21 1 
ATOM   3315 H HD22 . LEU A 1 227 ? -30.21998 -10.07357 34.02421  1.000 64.31537  ? 227 LEU A HD22 1 
ATOM   3316 H HD23 . LEU A 1 227 ? -31.44671 -9.48851  33.20180  1.000 64.31537  ? 227 LEU A HD23 1 
ATOM   3317 N N    . ASN A 1 228 ? -30.62721 -4.59869  32.42309  1.000 61.67675  ? 228 ASN A N    1 
ATOM   3318 C CA   . ASN A 1 228 ? -31.23460 -3.88174  31.30787  1.000 62.48742  ? 228 ASN A CA   1 
ATOM   3319 C C    . ASN A 1 228 ? -30.38574 -2.69493  30.86511  1.000 61.81769  ? 228 ASN A C    1 
ATOM   3320 O O    . ASN A 1 228 ? -30.35585 -2.37479  29.67175  1.000 62.51975  ? 228 ASN A O    1 
ATOM   3321 C CB   . ASN A 1 228 ? -32.64341 -3.42666  31.69862  1.000 62.92959  ? 228 ASN A CB   1 
ATOM   3322 C CG   . ASN A 1 228 ? -33.49301 -3.05406  30.50015  1.000 66.17224  ? 228 ASN A CG   1 
ATOM   3323 O OD1  . ASN A 1 228 ? -33.67977 -1.87433  30.20332  1.000 74.86905  ? 228 ASN A OD1  1 
ATOM   3324 N ND2  . ASN A 1 228 ? -34.01511 -4.05895  29.80568  1.000 80.05066  ? 228 ASN A ND2  1 
ATOM   3325 H H    . ASN A 1 228 ? -30.98023 -4.42860  33.18863  1.000 74.74817  ? 228 ASN A H    1 
ATOM   3326 H HA   . ASN A 1 228 ? -31.31644 -4.47777  30.54698  1.000 75.72097  ? 228 ASN A HA   1 
ATOM   3327 H HB2  . ASN A 1 228 ? -33.08925 -4.14794  32.16967  1.000 76.25158  ? 228 ASN A HB2  1 
ATOM   3328 H HB3  . ASN A 1 228 ? -32.57607 -2.64743  32.27236  1.000 76.25158  ? 228 ASN A HB3  1 
ATOM   3329 H HD21 . ASN A 1 228 ? -34.50446 -3.89733  29.11720  1.000 96.79687  ? 228 ASN A HD21 1 
ATOM   3330 H HD22 . ASN A 1 228 ? -33.86376 -4.87112  30.04458  1.000 96.79687  ? 228 ASN A HD22 1 
ATOM   3331 N N    . ASP A 1 229 ? -29.68205 -2.04073  31.79308  1.000 62.78256  ? 229 ASP A N    1 
ATOM   3332 C CA   . ASP A 1 229 ? -28.81767 -0.93078  31.40298  1.000 63.03460  ? 229 ASP A CA   1 
ATOM   3333 C C    . ASP A 1 229 ? -27.52936 -1.43019  30.75882  1.000 60.27450  ? 229 ASP A C    1 
ATOM   3334 O O    . ASP A 1 229 ? -27.00883 -0.79939  29.83106  1.000 56.47987  ? 229 ASP A O    1 
ATOM   3335 C CB   . ASP A 1 229 ? -28.49752 -0.04793  32.61031  1.000 71.14444  ? 229 ASP A CB   1 
ATOM   3336 C CG   . ASP A 1 229 ? -29.67703 0.79770   33.04314  1.000 69.83717  ? 229 ASP A CG   1 
ATOM   3337 O OD1  . ASP A 1 229 ? -30.49857 1.18261   32.17585  1.000 68.33889  ? 229 ASP A OD1  1 
ATOM   3338 O OD2  . ASP A 1 229 ? -29.79165 1.09125   34.25396  1.000 69.69669  ? 229 ASP A OD2  1 
ATOM   3339 H H    . ASP A 1 229 ? -29.68866 -2.21717  32.63476  1.000 76.07514  ? 229 ASP A H    1 
ATOM   3340 H HA   . ASP A 1 229 ? -29.29212 -0.38483  30.75665  1.000 76.37758  ? 229 ASP A HA   1 
ATOM   3341 H HB2  . ASP A 1 229 ? -28.24267 -0.61260  33.35670  1.000 86.10939  ? 229 ASP A HB2  1 
ATOM   3342 H HB3  . ASP A 1 229 ? -27.76786 0.54885   32.38150  1.000 86.10939  ? 229 ASP A HB3  1 
ATOM   3343 N N    . PHE A 1 230 ? -26.99350 -2.55378  31.24062  1.000 59.55840  ? 230 PHE A N    1 
ATOM   3344 C CA   . PHE A 1 230 ? -25.80864 -3.12535  30.60735  1.000 58.11894  ? 230 PHE A CA   1 
ATOM   3345 C C    . PHE A 1 230 ? -26.09408 -3.48520  29.15408  1.000 53.37135  ? 230 PHE A C    1 
ATOM   3346 O O    . PHE A 1 230 ? -25.34010 -3.11377  28.24712  1.000 53.82168  ? 230 PHE A O    1 
ATOM   3347 C CB   . PHE A 1 230 ? -25.33057 -4.36089  31.37183  1.000 58.24203  ? 230 PHE A CB   1 
ATOM   3348 C CG   . PHE A 1 230 ? -24.28397 -5.15353  30.63682  1.000 58.19671  ? 230 PHE A CG   1 
ATOM   3349 C CD1  . PHE A 1 230 ? -22.95431 -4.77027  30.67313  1.000 54.80686  ? 230 PHE A CD1  1 
ATOM   3350 C CD2  . PHE A 1 230 ? -24.63391 -6.27303  29.90130  1.000 53.45425  ? 230 PHE A CD2  1 
ATOM   3351 C CE1  . PHE A 1 230 ? -21.99081 -5.49254  29.99122  1.000 52.42373  ? 230 PHE A CE1  1 
ATOM   3352 C CE2  . PHE A 1 230 ? -23.67542 -7.00018  29.21866  1.000 50.17627  ? 230 PHE A CE2  1 
ATOM   3353 C CZ   . PHE A 1 230 ? -22.35331 -6.60832  29.26277  1.000 50.54161  ? 230 PHE A CZ   1 
ATOM   3354 H H    . PHE A 1 230 ? -27.29083 -2.99342  31.91730  1.000 72.20615  ? 230 PHE A H    1 
ATOM   3355 H HA   . PHE A 1 230 ? -25.09844 -2.46521  30.63427  1.000 70.47879  ? 230 PHE A HA   1 
ATOM   3356 H HB2  . PHE A 1 230 ? -24.94918 -4.07741  32.21745  1.000 70.62650  ? 230 PHE A HB2  1 
ATOM   3357 H HB3  . PHE A 1 230 ? -26.08926 -4.94446  31.52908  1.000 70.62650  ? 230 PHE A HB3  1 
ATOM   3358 H HD1  . PHE A 1 230 ? -22.70568 -4.01880  31.16137  1.000 66.50430  ? 230 PHE A HD1  1 
ATOM   3359 H HD2  . PHE A 1 230 ? -25.52424 -6.53940  29.86573  1.000 64.88117  ? 230 PHE A HD2  1 
ATOM   3360 H HE1  . PHE A 1 230 ? -21.10016 -5.22681  30.02349  1.000 63.64454  ? 230 PHE A HE1  1 
ATOM   3361 H HE2  . PHE A 1 230 ? -23.92195 -7.75240  28.73051  1.000 60.94760  ? 230 PHE A HE2  1 
ATOM   3362 H HZ   . PHE A 1 230 ? -21.70759 -7.09457  28.80288  1.000 61.38600  ? 230 PHE A HZ   1 
ATOM   3363 N N    . ASN A 1 231 ? -27.19965 -4.19663  28.91506  1.000 54.27573  ? 231 ASN A N    1 
ATOM   3364 C CA   . ASN A 1 231 ? -27.52218 -4.63012  27.55891  1.000 53.87105  ? 231 ASN A CA   1 
ATOM   3365 C C    . ASN A 1 231 ? -27.69885 -3.44532  26.61543  1.000 53.19387  ? 231 ASN A C    1 
ATOM   3366 O O    . ASN A 1 231 ? -27.51741 -3.58284  25.40090  1.000 52.36649  ? 231 ASN A O    1 
ATOM   3367 C CB   . ASN A 1 231 ? -28.77881 -5.49751  27.56817  1.000 52.98115  ? 231 ASN A CB   1 
ATOM   3368 C CG   . ASN A 1 231 ? -28.50877 -6.89916  28.07128  1.000 51.31749  ? 231 ASN A CG   1 
ATOM   3369 O OD1  . ASN A 1 231 ? -27.39448 -7.40975  27.94917  1.000 51.94980  ? 231 ASN A OD1  1 
ATOM   3370 N ND2  . ASN A 1 231 ? -29.52726 -7.53110  28.64093  1.000 50.07574  ? 231 ASN A ND2  1 
ATOM   3371 H H    . ASN A 1 231 ? -27.76956 -4.43676  29.51267  1.000 65.86694  ? 231 ASN A H    1 
ATOM   3372 H HA   . ASN A 1 231 ? -26.78980 -5.17050  27.22350  1.000 65.38133  ? 231 ASN A HA   1 
ATOM   3373 H HB2  . ASN A 1 231 ? -29.44078 -5.09107  28.14912  1.000 64.31345  ? 231 ASN A HB2  1 
ATOM   3374 H HB3  . ASN A 1 231 ? -29.12584 -5.56319  26.66476  1.000 64.31345  ? 231 ASN A HB3  1 
ATOM   3375 H HD21 . ASN A 1 231 ? -29.42331 -8.32972  28.94259  1.000 60.82695  ? 231 ASN A HD21 1 
ATOM   3376 H HD22 . ASN A 1 231 ? -30.29122 -7.14200  28.70841  1.000 60.82695  ? 231 ASN A HD22 1 
ATOM   3377 N N    . LEU A 1 232 ? -28.06898 -2.27339  27.14179  1.000 54.43322  ? 232 LEU A N    1 
ATOM   3378 C CA   . LEU A 1 232 ? -28.08614 -1.07817  26.30082  1.000 52.51470  ? 232 LEU A CA   1 
ATOM   3379 C C    . LEU A 1 232 ? -26.67863 -0.73607  25.82554  1.000 51.16425  ? 232 LEU A C    1 
ATOM   3380 O O    . LEU A 1 232 ? -26.48447 -0.29040  24.68744  1.000 52.40230  ? 232 LEU A O    1 
ATOM   3381 C CB   . LEU A 1 232 ? -28.69707 0.10085   27.05790  1.000 56.12671  ? 232 LEU A CB   1 
ATOM   3382 H H    . LEU A 1 232 ? -28.30734 -2.14875  27.95864  1.000 66.05594  ? 232 LEU A H    1 
ATOM   3383 H HA   . LEU A 1 232 ? -28.64311 -1.24798  25.52502  1.000 63.75370  ? 232 LEU A HA   1 
ATOM   3384 N N    . VAL A 1 233 ? -25.68007 -0.94338  26.68554  1.000 51.62366  ? 233 VAL A N    1 
ATOM   3385 C CA   . VAL A 1 233 ? -24.29353 -0.72856  26.28947  1.000 49.54952  ? 233 VAL A CA   1 
ATOM   3386 C C    . VAL A 1 233 ? -23.80192 -1.86533  25.40594  1.000 49.10453  ? 233 VAL A C    1 
ATOM   3387 O O    . VAL A 1 233 ? -23.07937 -1.63886  24.43149  1.000 48.64048  ? 233 VAL A O    1 
ATOM   3388 C CB   . VAL A 1 233 ? -23.39990 -0.56594  27.53371  1.000 52.06570  ? 233 VAL A CB   1 
ATOM   3389 C CG1  . VAL A 1 233 ? -21.92983 -0.52202  27.12463  1.000 51.22899  ? 233 VAL A CG1  1 
ATOM   3390 C CG2  . VAL A 1 233 ? -23.78869 0.67659   28.31678  1.000 53.48016  ? 233 VAL A CG2  1 
ATOM   3391 H H    . VAL A 1 233 ? -25.78002 -1.20669  27.49811  1.000 62.68446  ? 233 VAL A H    1 
ATOM   3392 H HA   . VAL A 1 233 ? -24.25044 0.09357   25.77649  1.000 60.19549  ? 233 VAL A HA   1 
ATOM   3393 H HB   . VAL A 1 233 ? -23.52689 -1.33003  28.11762  1.000 63.21491  ? 233 VAL A HB   1 
ATOM   3394 H HG11 . VAL A 1 233 ? -21.40078 -0.22062  27.87972  1.000 62.21086  ? 233 VAL A HG11 1 
ATOM   3395 H HG12 . VAL A 1 233 ? -21.64942 -1.41159  26.85832  1.000 62.21086  ? 233 VAL A HG12 1 
ATOM   3396 H HG13 . VAL A 1 233 ? -21.82695 0.09342   26.38196  1.000 62.21086  ? 233 VAL A HG13 1 
ATOM   3397 H HG21 . VAL A 1 233 ? -23.05026 0.93137   28.89185  1.000 64.91226  ? 233 VAL A HG21 1 
ATOM   3398 H HG22 . VAL A 1 233 ? -23.98555 1.39367   27.69393  1.000 64.91226  ? 233 VAL A HG22 1 
ATOM   3399 H HG23 . VAL A 1 233 ? -24.57271 0.47956   28.85287  1.000 64.91226  ? 233 VAL A HG23 1 
ATOM   3400 N N    . ALA A 1 234 ? -24.17027 -3.10303  25.73753  1.000 50.14121  ? 234 ALA A N    1 
ATOM   3401 C CA   . ALA A 1 234 ? -23.71471 -4.24471  24.95350  1.000 45.28082  ? 234 ALA A CA   1 
ATOM   3402 C C    . ALA A 1 234 ? -24.17173 -4.12679  23.50552  1.000 46.72148  ? 234 ALA A C    1 
ATOM   3403 O O    . ALA A 1 234 ? -23.36621 -4.24602  22.57557  1.000 44.44842  ? 234 ALA A O    1 
ATOM   3404 C CB   . ALA A 1 234 ? -24.22364 -5.54448  25.57778  1.000 45.27260  ? 234 ALA A CB   1 
ATOM   3405 H H    . ALA A 1 234 ? -24.67644 -3.30445  26.40297  1.000 60.90552  ? 234 ALA A H    1 
ATOM   3406 H HA   . ALA A 1 234 ? -22.74502 -4.26699  24.96355  1.000 55.07305  ? 234 ALA A HA   1 
ATOM   3407 H HB1  . ALA A 1 234 ? -23.93967 -6.29133  25.02780  1.000 55.06319  ? 234 ALA A HB1  1 
ATOM   3408 H HB2  . ALA A 1 234 ? -23.85435 -5.63183  26.47047  1.000 55.06319  ? 234 ALA A HB2  1 
ATOM   3409 H HB3  . ALA A 1 234 ? -25.19220 -5.51558  25.62185  1.000 55.06319  ? 234 ALA A HB3  1 
ATOM   3410 N N    . MET A 1 235 ? -25.46729 -3.88613  23.29570  1.000 48.26651  ? 235 MET A N    1 
ATOM   3411 C CA   . MET A 1 235 ? -25.98798 -3.76676  21.93799  1.000 51.82241  ? 235 MET A CA   1 
ATOM   3412 C C    . MET A 1 235 ? -25.19103 -2.75828  21.11882  1.000 47.64082  ? 235 MET A C    1 
ATOM   3413 O O    . MET A 1 235 ? -24.95278 -2.96941  19.92495  1.000 46.63297  ? 235 MET A O    1 
ATOM   3414 C CB   . MET A 1 235 ? -27.46469 -3.37728  21.98868  1.000 55.56035  ? 235 MET A CB   1 
ATOM   3415 C CG   . MET A 1 235 ? -28.00911 -2.81937  20.68872  1.000 69.49085  ? 235 MET A CG   1 
ATOM   3416 S SD   . MET A 1 235 ? -29.80917 -2.91459  20.61924  1.000 79.07426  ? 235 MET A SD   1 
ATOM   3417 C CE   . MET A 1 235 ? -30.25449 -2.25508  22.22578  1.000 67.18035  ? 235 MET A CE   1 
ATOM   3418 H H    . MET A 1 235 ? -26.05647 -3.78938  23.91466  1.000 58.65588  ? 235 MET A H    1 
ATOM   3419 H HA   . MET A 1 235 ? -25.92085 -4.63047  21.50163  1.000 62.92296  ? 235 MET A HA   1 
ATOM   3420 H HB2  . MET A 1 235 ? -27.98508 -4.16517  22.21077  1.000 67.40849  ? 235 MET A HB2  1 
ATOM   3421 H HB3  . MET A 1 235 ? -27.58244 -2.69856  22.67159  1.000 67.40849  ? 235 MET A HB3  1 
ATOM   3422 H HG2  . MET A 1 235 ? -27.75075 -1.88793  20.60764  1.000 84.12509  ? 235 MET A HG2  1 
ATOM   3423 H HG3  . MET A 1 235 ? -27.64898 -3.32938  19.94637  1.000 84.12509  ? 235 MET A HG3  1 
ATOM   3424 H HE1  . MET A 1 235 ? -31.21823 -2.15420  22.26964  1.000 81.35249  ? 235 MET A HE1  1 
ATOM   3425 H HE2  . MET A 1 235 ? -29.95460 -2.86974  22.91365  1.000 81.35249  ? 235 MET A HE2  1 
ATOM   3426 H HE3  . MET A 1 235 ? -29.82597 -1.39281  22.34300  1.000 81.35249  ? 235 MET A HE3  1 
ATOM   3427 N N    . LYS A 1 236 ? -24.76465 -1.65801  21.74233  1.000 47.81769  ? 236 LYS A N    1 
ATOM   3428 C CA   . LYS A 1 236 ? -23.96426 -0.66696  21.02834  1.000 50.89079  ? 236 LYS A CA   1 
ATOM   3429 C C    . LYS A 1 236 ? -22.65338 -1.25754  20.52855  1.000 47.61479  ? 236 LYS A C    1 
ATOM   3430 O O    . LYS A 1 236 ? -22.17880 -0.88413  19.45077  1.000 44.31463  ? 236 LYS A O    1 
ATOM   3431 C CB   . LYS A 1 236 ? -23.70285 0.53262   21.94143  1.000 52.16901  ? 236 LYS A CB   1 
ATOM   3432 C CG   . LYS A 1 236 ? -22.75384 1.60388   21.39843  1.000 54.30182  ? 236 LYS A CG   1 
ATOM   3433 C CD   . LYS A 1 236 ? -22.75109 2.82068   22.33247  1.000 70.63138  ? 236 LYS A CD   1 
ATOM   3434 C CE   . LYS A 1 236 ? -21.47274 3.64482   22.23909  1.000 62.14835  ? 236 LYS A CE   1 
ATOM   3435 N NZ   . LYS A 1 236 ? -21.43414 4.53387   21.04576  1.000 61.33179  ? 236 LYS A NZ   1 
ATOM   3436 H H    . LYS A 1 236 ? -24.92298 -1.46535  22.56538  1.000 58.11729  ? 236 LYS A H    1 
ATOM   3437 H HA   . LYS A 1 236 ? -24.45828 -0.35617  20.25358  1.000 61.80501  ? 236 LYS A HA   1 
ATOM   3438 H HB2  . LYS A 1 236 ? -24.55160 0.96715   22.11947  1.000 63.33888  ? 236 LYS A HB2  1 
ATOM   3439 H HB3  . LYS A 1 236 ? -23.31836 0.20393   22.76909  1.000 63.33888  ? 236 LYS A HB3  1 
ATOM   3440 H HG2  . LYS A 1 236 ? -21.85294 1.24793   21.34776  1.000 65.89825  ? 236 LYS A HG2  1 
ATOM   3441 H HG3  . LYS A 1 236 ? -23.04867 1.88699   20.51876  1.000 65.89825  ? 236 LYS A HG3  1 
ATOM   3442 H HD2  . LYS A 1 236 ? -23.49521 3.39787   22.10002  1.000 85.49372  ? 236 LYS A HD2  1 
ATOM   3443 H HD3  . LYS A 1 236 ? -22.84202 2.51482   23.24848  1.000 85.49372  ? 236 LYS A HD3  1 
ATOM   3444 H HE2  . LYS A 1 236 ? -21.39993 4.20314   23.02894  1.000 75.31409  ? 236 LYS A HE2  1 
ATOM   3445 H HE3  . LYS A 1 236 ? -20.71364 3.04319   22.18696  1.000 75.31409  ? 236 LYS A HE3  1 
ATOM   3446 H HZ1  . LYS A 1 236 ? -20.65726 4.96691   21.01379  1.000 74.33421  ? 236 LYS A HZ1  1 
ATOM   3447 H HZ2  . LYS A 1 236 ? -21.52664 4.05141   20.30361  1.000 74.33421  ? 236 LYS A HZ2  1 
ATOM   3448 H HZ3  . LYS A 1 236 ? -22.09485 5.12867   21.08781  1.000 74.33421  ? 236 LYS A HZ3  1 
ATOM   3449 N N    . TYR A 1 237 ? -22.06534 -2.19142  21.27721  1.000 44.76242  ? 237 TYR A N    1 
ATOM   3450 C CA   . TYR A 1 237 ? -20.77117 -2.77098  20.94161  1.000 43.70715  ? 237 TYR A CA   1 
ATOM   3451 C C    . TYR A 1 237 ? -20.88793 -4.17441  20.35194  1.000 40.30146  ? 237 TYR A C    1 
ATOM   3452 O O    . TYR A 1 237 ? -19.92634 -4.94855  20.41238  1.000 40.48352  ? 237 TYR A O    1 
ATOM   3453 C CB   . TYR A 1 237 ? -19.87283 -2.78050  22.18142  1.000 42.59699  ? 237 TYR A CB   1 
ATOM   3454 C CG   . TYR A 1 237 ? -19.50322 -1.39195  22.65608  1.000 47.13697  ? 237 TYR A CG   1 
ATOM   3455 C CD1  . TYR A 1 237 ? -20.33744 -0.68148  23.51134  1.000 49.26081  ? 237 TYR A CD1  1 
ATOM   3456 C CD2  . TYR A 1 237 ? -18.32632 -0.78582  22.23756  1.000 46.60485  ? 237 TYR A CD2  1 
ATOM   3457 C CE1  . TYR A 1 237 ? -20.00369 0.59252   23.93950  1.000 51.11898  ? 237 TYR A CE1  1 
ATOM   3458 C CE2  . TYR A 1 237 ? -17.98515 0.48525   22.66100  1.000 50.71343  ? 237 TYR A CE2  1 
ATOM   3459 C CZ   . TYR A 1 237 ? -18.82724 1.16976   23.51161  1.000 50.85221  ? 237 TYR A CZ   1 
ATOM   3460 O OH   . TYR A 1 237 ? -18.48694 2.43532   23.93050  1.000 54.17597  ? 237 TYR A OH   1 
ATOM   3461 H H    . TYR A 1 237 ? -22.40658 -2.51015  21.99941  1.000 54.45097  ? 237 TYR A H    1 
ATOM   3462 H HA   . TYR A 1 237 ? -20.34929 -2.21489  20.26805  1.000 53.18465  ? 237 TYR A HA   1 
ATOM   3463 H HB2  . TYR A 1 237 ? -20.33879 -3.22944  22.90408  1.000 51.85245  ? 237 TYR A HB2  1 
ATOM   3464 H HB3  . TYR A 1 237 ? -19.05217 -3.25317  21.97164  1.000 51.85245  ? 237 TYR A HB3  1 
ATOM   3465 H HD1  . TYR A 1 237 ? -21.13238 -1.06786  23.80063  1.000 59.84904  ? 237 TYR A HD1  1 
ATOM   3466 H HD2  . TYR A 1 237 ? -17.75701 -1.24328  21.66179  1.000 56.66189  ? 237 TYR A HD2  1 
ATOM   3467 H HE1  . TYR A 1 237 ? -20.57036 1.05631   24.51281  1.000 62.07885  ? 237 TYR A HE1  1 
ATOM   3468 H HE2  . TYR A 1 237 ? -17.19191 0.87652   22.37365  1.000 61.59218  ? 237 TYR A HE2  1 
ATOM   3469 H HH   . TYR A 1 237 ? -19.11181 2.76538   24.38458  1.000 65.74723  ? 237 TYR A HH   1 
ATOM   3470 N N    . ASN A 1 238 ? -22.04133 -4.50736  19.77045  1.000 42.45265  ? 238 ASN A N    1 
ATOM   3471 C CA   . ASN A 1 238 ? -22.26872 -5.80629  19.13214  1.000 39.93008  ? 238 ASN A CA   1 
ATOM   3472 C C    . ASN A 1 238 ? -21.91846 -6.96060  20.06898  1.000 38.68221  ? 238 ASN A C    1 
ATOM   3473 O O    . ASN A 1 238 ? -21.34965 -7.97667  19.65907  1.000 36.56382  ? 238 ASN A O    1 
ATOM   3474 C CB   . ASN A 1 238 ? -21.49746 -5.91175  17.81464  1.000 38.10901  ? 238 ASN A CB   1 
ATOM   3475 C CG   . ASN A 1 238 ? -22.23989 -5.27229  16.65313  1.000 44.18335  ? 238 ASN A CG   1 
ATOM   3476 O OD1  . ASN A 1 238 ? -22.89599 -5.95789  15.86790  1.000 49.61433  ? 238 ASN A OD1  1 
ATOM   3477 N ND2  . ASN A 1 238 ? -22.14811 -3.95106  16.54625  1.000 46.13912  ? 238 ASN A ND2  1 
ATOM   3478 H H    . ASN A 1 238 ? -22.72425 -3.98613  19.73119  1.000 51.67924  ? 238 ASN A H    1 
ATOM   3479 H HA   . ASN A 1 238 ? -23.21474 -5.88109  18.93127  1.000 48.65216  ? 238 ASN A HA   1 
ATOM   3480 H HB2  . ASN A 1 238 ? -20.64348 -5.46179  17.91028  1.000 46.46688  ? 238 ASN A HB2  1 
ATOM   3481 H HB3  . ASN A 1 238 ? -21.35731 -6.84803  17.60337  1.000 46.46688  ? 238 ASN A HB3  1 
ATOM   3482 H HD21 . ASN A 1 238 ? -22.55065 -3.54250  15.90543  1.000 56.10301  ? 238 ASN A HD21 1 
ATOM   3483 H HD22 . ASN A 1 238 ? -21.68617 -3.50447  17.11788  1.000 56.10301  ? 238 ASN A HD22 1 
ATOM   3484 N N    . TYR A 1 239 ? -22.26816 -6.79224  21.34375  1.000 34.93943  ? 239 TYR A N    1 
ATOM   3485 C CA   . TYR A 1 239 ? -22.21467 -7.87099  22.31796  1.000 35.87642  ? 239 TYR A CA   1 
ATOM   3486 C C    . TYR A 1 239 ? -23.58474 -8.52719  22.41739  1.000 36.01413  ? 239 TYR A C    1 
ATOM   3487 O O    . TYR A 1 239 ? -24.61171 -7.84543  22.43893  1.000 36.24633  ? 239 TYR A O    1 
ATOM   3488 C CB   . TYR A 1 239 ? -21.79355 -7.33055  23.68387  1.000 33.25222  ? 239 TYR A CB   1 
ATOM   3489 C CG   . TYR A 1 239 ? -20.30925 -7.39443  23.92941  1.000 34.21789  ? 239 TYR A CG   1 
ATOM   3490 C CD1  . TYR A 1 239 ? -19.42199 -6.75563  23.07979  1.000 34.13481  ? 239 TYR A CD1  1 
ATOM   3491 C CD2  . TYR A 1 239 ? -19.79391 -8.09026  25.01467  1.000 31.38052  ? 239 TYR A CD2  1 
ATOM   3492 C CE1  . TYR A 1 239 ? -18.06132 -6.81270  23.29589  1.000 34.38921  ? 239 TYR A CE1  1 
ATOM   3493 C CE2  . TYR A 1 239 ? -18.43627 -8.15047  25.24100  1.000 34.17644  ? 239 TYR A CE2  1 
ATOM   3494 C CZ   . TYR A 1 239 ? -17.57377 -7.51038  24.37647  1.000 32.70957  ? 239 TYR A CZ   1 
ATOM   3495 O OH   . TYR A 1 239 ? -16.21642 -7.56011  24.59288  1.000 33.93897  ? 239 TYR A OH   1 
ATOM   3496 H H    . TYR A 1 239 ? -22.54459 -6.04670  21.67139  1.000 42.66338  ? 239 TYR A H    1 
ATOM   3497 H HA   . TYR A 1 239 ? -21.56630 -8.53867  22.04460  1.000 43.78777  ? 239 TYR A HA   1 
ATOM   3498 H HB2  . TYR A 1 239 ? -22.06484 -6.40154  23.74894  1.000 40.63873  ? 239 TYR A HB2  1 
ATOM   3499 H HB3  . TYR A 1 239 ? -22.23077 -7.85299  24.37438  1.000 40.63873  ? 239 TYR A HB3  1 
ATOM   3500 H HD1  . TYR A 1 239 ? -19.74938 -6.27990  22.35082  1.000 41.69783  ? 239 TYR A HD1  1 
ATOM   3501 H HD2  . TYR A 1 239 ? -20.37460 -8.52275  25.59832  1.000 38.39269  ? 239 TYR A HD2  1 
ATOM   3502 H HE1  . TYR A 1 239 ? -17.47682 -6.38212  22.71463  1.000 42.00313  ? 239 TYR A HE1  1 
ATOM   3503 H HE2  . TYR A 1 239 ? -18.10384 -8.61966  25.97193  1.000 41.74780  ? 239 TYR A HE2  1 
ATOM   3504 H HH   . TYR A 1 239 ? -16.05973 -7.81819  25.37674  1.000 41.46284  ? 239 TYR A HH   1 
ATOM   3505 N N    . GLU A 1 240 ? -23.59918 -9.85210  22.47063  1.000 35.06302  ? 240 GLU A N    1 
ATOM   3506 C CA   . GLU A 1 240 ? -24.86823 -10.55967 22.57308  1.000 38.20094  ? 240 GLU A CA   1 
ATOM   3507 C C    . GLU A 1 240 ? -25.57018 -10.16436 23.87090  1.000 37.67588  ? 240 GLU A C    1 
ATOM   3508 O O    . GLU A 1 240 ? -24.90967 -9.94746  24.89374  1.000 38.14952  ? 240 GLU A O    1 
ATOM   3509 C CB   . GLU A 1 240 ? -24.64939 -12.07222 22.52915  1.000 34.69937  ? 240 GLU A CB   1 
ATOM   3510 H H    . GLU A 1 240 ? -22.90283 -10.35635 22.44971  1.000 42.81169  ? 240 GLU A H    1 
ATOM   3511 H HA   . GLU A 1 240 ? -25.43800 -10.31994 21.82556  1.000 46.57719  ? 240 GLU A HA   1 
ATOM   3512 N N    . PRO A 1 241 ? -26.89716 -10.05299 23.86796  1.000 40.04725  ? 241 PRO A N    1 
ATOM   3513 C CA   . PRO A 1 241 ? -27.60099 -9.68411  25.10449  1.000 41.33794  ? 241 PRO A CA   1 
ATOM   3514 C C    . PRO A 1 241 ? -27.34676 -10.69881 26.21048  1.000 41.80849  ? 241 PRO A C    1 
ATOM   3515 O O    . PRO A 1 241 ? -27.29599 -11.90657 25.96980  1.000 43.93362  ? 241 PRO A O    1 
ATOM   3516 C CB   . PRO A 1 241 ? -29.07817 -9.66331  24.68547  1.000 44.68408  ? 241 PRO A CB   1 
ATOM   3517 C CG   . PRO A 1 241 ? -29.06487 -9.54918  23.17885  1.000 43.54798  ? 241 PRO A CG   1 
ATOM   3518 C CD   . PRO A 1 241 ? -27.82011 -10.26455 22.73660  1.000 39.43712  ? 241 PRO A CD   1 
ATOM   3519 H HA   . PRO A 1 241 ? -27.33251 -8.80056  25.40142  1.000 50.34159  ? 241 PRO A HA   1 
ATOM   3520 H HB2  . PRO A 1 241 ? -29.51113 -10.48464 24.96630  1.000 54.35696  ? 241 PRO A HB2  1 
ATOM   3521 H HB3  . PRO A 1 241 ? -29.52284 -8.90006  25.08623  1.000 54.35696  ? 241 PRO A HB3  1 
ATOM   3522 H HG2  . PRO A 1 241 ? -29.85590 -9.97216  22.80971  1.000 52.99364  ? 241 PRO A HG2  1 
ATOM   3523 H HG3  . PRO A 1 241 ? -29.03675 -8.61485  22.91976  1.000 52.99364  ? 241 PRO A HG3  1 
ATOM   3524 H HD2  . PRO A 1 241 ? -27.99276 -11.20957 22.60232  1.000 48.06061  ? 241 PRO A HD2  1 
ATOM   3525 H HD3  . PRO A 1 241 ? -27.46610 -9.87306  21.92277  1.000 48.06061  ? 241 PRO A HD3  1 
ATOM   3526 N N    . LEU A 1 242 ? -27.18877 -10.19773 27.43454  1.000 43.24949  ? 242 LEU A N    1 
ATOM   3527 C CA   . LEU A 1 242 ? -26.96334 -11.05203 28.59467  1.000 44.33195  ? 242 LEU A CA   1 
ATOM   3528 C C    . LEU A 1 242 ? -28.30375 -11.37286 29.24716  1.000 47.54387  ? 242 LEU A C    1 
ATOM   3529 O O    . LEU A 1 242 ? -29.01927 -10.46481 29.68617  1.000 46.32290  ? 242 LEU A O    1 
ATOM   3530 C CB   . LEU A 1 242 ? -26.03042 -10.38207 29.60154  1.000 43.28291  ? 242 LEU A CB   1 
ATOM   3531 C CG   . LEU A 1 242 ? -25.48484 -11.31909 30.68321  1.000 43.88038  ? 242 LEU A CG   1 
ATOM   3532 C CD1  . LEU A 1 242 ? -24.47741 -12.29559 30.07923  1.000 42.18511  ? 242 LEU A CD1  1 
ATOM   3533 C CD2  . LEU A 1 242 ? -24.86691 -10.53899 31.83100  1.000 43.50891  ? 242 LEU A CD2  1 
ATOM   3534 H H    . LEU A 1 242 ? -27.20855 -9.35788  27.61856  1.000 52.63546  ? 242 LEU A H    1 
ATOM   3535 H HA   . LEU A 1 242 ? -26.54825 -11.87870 28.30277  1.000 53.93441  ? 242 LEU A HA   1 
ATOM   3536 H HB2  . LEU A 1 242 ? -25.27182 -10.01446 29.12165  1.000 52.67556  ? 242 LEU A HB2  1 
ATOM   3537 H HB3  . LEU A 1 242 ? -26.51721 -9.67119  30.04717  1.000 52.67556  ? 242 LEU A HB3  1 
ATOM   3538 H HG   . LEU A 1 242 ? -26.22111 -11.83214 31.05144  1.000 53.39252  ? 242 LEU A HG   1 
ATOM   3539 H HD11 . LEU A 1 242 ? -24.03098 -12.77252 30.79626  1.000 51.35820  ? 242 LEU A HD11 1 
ATOM   3540 H HD12 . LEU A 1 242 ? -24.94850 -12.92238 29.50816  1.000 51.35820  ? 242 LEU A HD12 1 
ATOM   3541 H HD13 . LEU A 1 242 ? -23.82792 -11.79754 29.55864  1.000 51.35820  ? 242 LEU A HD13 1 
ATOM   3542 H HD21 . LEU A 1 242 ? -24.43822 -11.16014 32.44034  1.000 52.94675  ? 242 LEU A HD21 1 
ATOM   3543 H HD22 . LEU A 1 242 ? -24.21116 -9.91931  31.47477  1.000 52.94675  ? 242 LEU A HD22 1 
ATOM   3544 H HD23 . LEU A 1 242 ? -25.56599 -10.05102 32.29368  1.000 52.94675  ? 242 LEU A HD23 1 
ATOM   3545 N N    . THR A 1 243 ? -28.64032 -12.65718 29.30985  1.000 45.67797  ? 243 THR A N    1 
ATOM   3546 C CA   . THR A 1 243 ? -29.90026 -13.09005 29.88881  1.000 43.42743  ? 243 THR A CA   1 
ATOM   3547 C C    . THR A 1 243 ? -29.71405 -13.44336 31.36308  1.000 48.70133  ? 243 THR A C    1 
ATOM   3548 O O    . THR A 1 243 ? -28.59950 -13.47352 31.89061  1.000 46.36874  ? 243 THR A O    1 
ATOM   3549 C CB   . THR A 1 243 ? -30.45881 -14.29411 29.12756  1.000 46.77343  ? 243 THR A CB   1 
ATOM   3550 O OG1  . THR A 1 243 ? -29.65124 -15.44744 29.39941  1.000 49.91035  ? 243 THR A OG1  1 
ATOM   3551 C CG2  . THR A 1 243 ? -30.47387 -14.02836 27.62708  1.000 48.05342  ? 243 THR A CG2  1 
ATOM   3552 H H    . THR A 1 243 ? -28.14905 -13.30087 29.02017  1.000 55.54963  ? 243 THR A H    1 
ATOM   3553 H HA   . THR A 1 243 ? -30.54175 -12.36555 29.82178  1.000 52.84899  ? 243 THR A HA   1 
ATOM   3554 H HB   . THR A 1 243 ? -31.37090 -14.46034 29.41282  1.000 56.86419  ? 243 THR A HB   1 
ATOM   3555 H HG1  . THR A 1 243 ? -30.05260 -16.14346 29.15431  1.000 60.62848  ? 243 THR A HG1  1 
ATOM   3556 H HG21 . THR A 1 243 ? -30.96088 -14.73204 27.17040  1.000 58.40017  ? 243 THR A HG21 1 
ATOM   3557 H HG22 . THR A 1 243 ? -30.90429 -13.17837 27.44500  1.000 58.40017  ? 243 THR A HG22 1 
ATOM   3558 H HG23 . THR A 1 243 ? -29.56628 -14.00111 27.28585  1.000 58.40017  ? 243 THR A HG23 1 
ATOM   3559 N N    . GLN A 1 244 ? -30.83616 -13.71444 32.03329  1.000 47.99109  ? 244 GLN A N    1 
ATOM   3560 C CA   . GLN A 1 244 ? -30.77530 -14.17110 33.41728  1.000 48.11993  ? 244 GLN A CA   1 
ATOM   3561 C C    . GLN A 1 244 ? -30.19001 -15.57433 33.51194  1.000 44.97255  ? 244 GLN A C    1 
ATOM   3562 O O    . GLN A 1 244 ? -29.50652 -15.89350 34.49166  1.000 43.90974  ? 244 GLN A O    1 
ATOM   3563 C CB   . GLN A 1 244 ? -32.16959 -14.12050 34.04265  1.000 50.26168  ? 244 GLN A CB   1 
ATOM   3564 C CG   . GLN A 1 244 ? -32.25543 -14.67363 35.45574  1.000 50.05143  ? 244 GLN A CG   1 
ATOM   3565 C CD   . GLN A 1 244 ? -31.41755 -13.89354 36.45560  1.000 49.91461  ? 244 GLN A CD   1 
ATOM   3566 O OE1  . GLN A 1 244 ? -31.43917 -12.66233 36.48107  1.000 49.61539  ? 244 GLN A OE1  1 
ATOM   3567 N NE2  . GLN A 1 244 ? -30.67305 -14.61319 37.28714  1.000 49.47649  ? 244 GLN A NE2  1 
ATOM   3568 H H    . GLN A 1 244 ? -31.63121 -13.64274 31.71335  1.000 58.32538  ? 244 GLN A H    1 
ATOM   3569 H HA   . GLN A 1 244 ? -30.20236 -13.57625 33.92601  1.000 58.47998  ? 244 GLN A HA   1 
ATOM   3570 H HB2  . GLN A 1 244 ? -32.45957 -13.19538 34.07351  1.000 61.05008  ? 244 GLN A HB2  1 
ATOM   3571 H HB3  . GLN A 1 244 ? -32.77405 -14.63936 33.48919  1.000 61.05008  ? 244 GLN A HB3  1 
ATOM   3572 H HG2  . GLN A 1 244 ? -33.17890 -14.64074 35.75075  1.000 60.79778  ? 244 GLN A HG2  1 
ATOM   3573 H HG3  . GLN A 1 244 ? -31.94016 -15.59096 35.45405  1.000 60.79778  ? 244 GLN A HG3  1 
ATOM   3574 H HE21 . GLN A 1 244 ? -30.68369 -15.47185 37.24028  1.000 60.10785  ? 244 GLN A HE21 1 
ATOM   3575 H HE22 . GLN A 1 244 ? -30.18030 -14.22057 37.87249  1.000 60.10785  ? 244 GLN A HE22 1 
ATOM   3576 N N    . ASP A 1 245 ? -30.44440 -16.42380 32.51242  1.000 46.58723  ? 245 ASP A N    1 
ATOM   3577 C CA   . ASP A 1 245 ? -29.79556 -17.73057 32.48012  1.000 48.19556  ? 245 ASP A CA   1 
ATOM   3578 C C    . ASP A 1 245 ? -28.27982 -17.58235 32.50001  1.000 45.92238  ? 245 ASP A C    1 
ATOM   3579 O O    . ASP A 1 245 ? -27.58139 -18.31748 33.20776  1.000 43.14967  ? 245 ASP A O    1 
ATOM   3580 C CB   . ASP A 1 245 ? -30.22966 -18.50900 31.23893  1.000 48.56963  ? 245 ASP A CB   1 
ATOM   3581 C CG   . ASP A 1 245 ? -31.72197 -18.74426 31.18966  1.000 54.45936  ? 245 ASP A CG   1 
ATOM   3582 O OD1  . ASP A 1 245 ? -32.41593 -18.38267 32.16307  1.000 51.48018  ? 245 ASP A OD1  1 
ATOM   3583 O OD2  . ASP A 1 245 ? -32.20336 -19.28870 30.17315  1.000 67.05879  ? 245 ASP A OD2  1 
ATOM   3584 H H    . ASP A 1 245 ? -30.97768 -16.26903 31.85571  1.000 56.64075  ? 245 ASP A H    1 
ATOM   3585 H HA   . ASP A 1 245 ? -30.07063 -18.23407 33.26224  1.000 58.57074  ? 245 ASP A HA   1 
ATOM   3586 H HB2  . ASP A 1 245 ? -29.97860 -18.00769 30.44738  1.000 59.01962  ? 245 ASP A HB2  1 
ATOM   3587 H HB3  . ASP A 1 245 ? -29.78941 -19.37334 31.23771  1.000 59.01962  ? 245 ASP A HB3  1 
ATOM   3588 N N    . HIS A 1 246 ? -27.75284 -16.64037 31.71767  1.000 44.31433  ? 246 HIS A N    1 
ATOM   3589 C CA   . HIS A 1 246 ? -26.31959 -16.37091 31.73863  1.000 43.51716  ? 246 HIS A CA   1 
ATOM   3590 C C    . HIS A 1 246 ? -25.86516 -15.98537 33.14322  1.000 42.00363  ? 246 HIS A C    1 
ATOM   3591 O O    . HIS A 1 246 ? -24.85567 -16.49086 33.64503  1.000 39.00138  ? 246 HIS A O    1 
ATOM   3592 C CB   . HIS A 1 246 ? -25.98300 -15.27461 30.72460  1.000 43.13533  ? 246 HIS A CB   1 
ATOM   3593 C CG   . HIS A 1 246 ? -26.23543 -15.66915 29.29941  1.000 42.49924  ? 246 HIS A CG   1 
ATOM   3594 N ND1  . HIS A 1 246 ? -26.50637 -14.74933 28.30967  1.000 42.38748  ? 246 HIS A ND1  1 
ATOM   3595 C CD2  . HIS A 1 246 ? -26.25366 -16.88310 28.69851  1.000 42.45883  ? 246 HIS A CD2  1 
ATOM   3596 C CE1  . HIS A 1 246 ? -26.68672 -15.37862 27.16182  1.000 42.06024  ? 246 HIS A CE1  1 
ATOM   3597 N NE2  . HIS A 1 246 ? -26.53680 -16.67409 27.36984  1.000 41.67539  ? 246 HIS A NE2  1 
ATOM   3598 H H    . HIS A 1 246 ? -28.19980 -16.14879 31.17161  1.000 53.91326  ? 246 HIS A H    1 
ATOM   3599 H HA   . HIS A 1 246 ? -25.83639 -17.17068 31.47828  1.000 52.95666  ? 246 HIS A HA   1 
ATOM   3600 H HB2  . HIS A 1 246 ? -26.52722 -14.49492 30.91646  1.000 52.49847  ? 246 HIS A HB2  1 
ATOM   3601 H HB3  . HIS A 1 246 ? -25.04268 -15.05142 30.80758  1.000 52.49847  ? 246 HIS A HB3  1 
ATOM   3602 H HD2  . HIS A 1 246 ? -26.10282 -17.70422 29.10827  1.000 51.68667  ? 246 HIS A HD2  1 
ATOM   3603 H HE1  . HIS A 1 246 ? -26.88534 -14.97763 26.34656  1.000 51.20835  ? 246 HIS A HE1  1 
ATOM   3604 H HE2  . HIS A 1 246 ? -26.60524 -17.28754 26.77101  1.000 50.74654  ? 246 HIS A HE2  1 
ATOM   3605 N N    . VAL A 1 247 ? -26.61718 -15.10004 33.80400  1.000 41.09052  ? 247 VAL A N    1 
ATOM   3606 C CA   . VAL A 1 247 ? -26.26677 -14.69047 35.16328  1.000 41.68518  ? 247 VAL A CA   1 
ATOM   3607 C C    . VAL A 1 247 ? -26.21881 -15.90189 36.08641  1.000 41.58868  ? 247 VAL A C    1 
ATOM   3608 O O    . VAL A 1 247 ? -25.28660 -16.06339 36.88453  1.000 40.18051  ? 247 VAL A O    1 
ATOM   3609 C CB   . VAL A 1 247 ? -27.26131 -13.63445 35.67949  1.000 44.41337  ? 247 VAL A CB   1 
ATOM   3610 C CG1  . VAL A 1 247 ? -26.99435 -13.32314 37.14552  1.000 43.86513  ? 247 VAL A CG1  1 
ATOM   3611 C CG2  . VAL A 1 247 ? -27.17901 -12.37551 34.83863  1.000 44.91787  ? 247 VAL A CG2  1 
ATOM   3612 H H    . VAL A 1 247 ? -27.32601 -14.72712 33.49081  1.000 50.04470  ? 247 VAL A H    1 
ATOM   3613 H HA   . VAL A 1 247 ? -25.38325 -14.29055 35.14442  1.000 50.75828  ? 247 VAL A HA   1 
ATOM   3614 H HB   . VAL A 1 247 ? -28.16210 -13.98690 35.60692  1.000 54.03211  ? 247 VAL A HB   1 
ATOM   3615 H HG11 . VAL A 1 247 ? -27.39534 -12.46756 37.36479  1.000 53.37422  ? 247 VAL A HG11 1 
ATOM   3616 H HG12 . VAL A 1 247 ? -27.38551 -14.02180 37.69304  1.000 53.37422  ? 247 VAL A HG12 1 
ATOM   3617 H HG13 . VAL A 1 247 ? -26.03604 -13.28634 37.29112  1.000 53.37422  ? 247 VAL A HG13 1 
ATOM   3618 H HG21 . VAL A 1 247 ? -27.77614 -11.70771 35.21060  1.000 54.63752  ? 247 VAL A HG21 1 
ATOM   3619 H HG22 . VAL A 1 247 ? -26.26650 -12.04677 34.85071  1.000 54.63752  ? 247 VAL A HG22 1 
ATOM   3620 H HG23 . VAL A 1 247 ? -27.44297 -12.58539 33.92913  1.000 54.63752  ? 247 VAL A HG23 1 
ATOM   3621 N N    . ASP A 1 248 ? -27.23323 -16.76760 35.99791  1.000 43.38358  ? 248 ASP A N    1 
ATOM   3622 C CA   . ASP A 1 248 ? -27.25551 -17.97305 36.82071  1.000 42.19089  ? 248 ASP A CA   1 
ATOM   3623 C C    . ASP A 1 248 ? -26.06465 -18.87378 36.51668  1.000 41.96476  ? 248 ASP A C    1 
ATOM   3624 O O    . ASP A 1 248 ? -25.47875 -19.47349 37.42664  1.000 41.87452  ? 248 ASP A O    1 
ATOM   3625 C CB   . ASP A 1 248 ? -28.56038 -18.73913 36.59715  1.000 43.76285  ? 248 ASP A CB   1 
ATOM   3626 C CG   . ASP A 1 248 ? -29.76313 -18.04934 37.21572  1.000 46.91170  ? 248 ASP A CG   1 
ATOM   3627 O OD1  . ASP A 1 248 ? -29.57551 -17.08480 37.98579  1.000 46.10032  ? 248 ASP A OD1  1 
ATOM   3628 O OD2  . ASP A 1 248 ? -30.90038 -18.47772 36.92713  1.000 46.90851  ? 248 ASP A OD2  1 
ATOM   3629 H H    . ASP A 1 248 ? -27.91078 -16.67953 35.47564  1.000 52.79636  ? 248 ASP A H    1 
ATOM   3630 H HA   . ASP A 1 248 ? -27.21003 -17.70950 37.75311  1.000 51.36514  ? 248 ASP A HA   1 
ATOM   3631 H HB2  . ASP A 1 248 ? -28.71933 -18.82036 35.64372  1.000 53.25148  ? 248 ASP A HB2  1 
ATOM   3632 H HB3  . ASP A 1 248 ? -28.48190 -19.61957 36.99660  1.000 53.25148  ? 248 ASP A HB3  1 
ATOM   3633 N N    . ILE A 1 249 ? -25.70238 -18.99393 35.23782  1.000 40.54899  ? 249 ILE A N    1 
ATOM   3634 C CA   . ILE A 1 249 ? -24.58703 -19.85318 34.85135  1.000 40.56761  ? 249 ILE A CA   1 
ATOM   3635 C C    . ILE A 1 249 ? -23.28037 -19.33394 35.43612  1.000 38.23642  ? 249 ILE A C    1 
ATOM   3636 O O    . ILE A 1 249 ? -22.35717 -20.11266 35.70562  1.000 38.18213  ? 249 ILE A O    1 
ATOM   3637 C CB   . ILE A 1 249 ? -24.52775 -19.96234 33.31339  1.000 39.66593  ? 249 ILE A CB   1 
ATOM   3638 C CG1  . ILE A 1 249 ? -25.71454 -20.78030 32.79319  1.000 40.38554  ? 249 ILE A CG1  1 
ATOM   3639 C CG2  . ILE A 1 249 ? -23.22673 -20.59335 32.85898  1.000 41.87431  ? 249 ILE A CG2  1 
ATOM   3640 C CD1  . ILE A 1 249 ? -25.99683 -20.60025 31.30898  1.000 43.77811  ? 249 ILE A CD1  1 
ATOM   3641 H H    . ILE A 1 249 ? -26.08384 -18.59128 34.58058  1.000 49.39486  ? 249 ILE A H    1 
ATOM   3642 H HA   . ILE A 1 249 ? -24.73117 -20.74246 35.21095  1.000 49.41720  ? 249 ILE A HA   1 
ATOM   3643 H HB   . ILE A 1 249 ? -24.57533 -19.06375 32.95121  1.000 48.33518  ? 249 ILE A HB   1 
ATOM   3644 H HG12 . ILE A 1 249 ? -25.53301 -21.72089 32.94563  1.000 49.19871  ? 249 ILE A HG12 1 
ATOM   3645 H HG13 . ILE A 1 249 ? -26.51106 -20.51330 33.27814  1.000 49.19871  ? 249 ILE A HG13 1 
ATOM   3646 H HG21 . ILE A 1 249 ? -23.26068 -20.73088 31.89938  1.000 50.98524  ? 249 ILE A HG21 1 
ATOM   3647 H HG22 . ILE A 1 249 ? -22.49287 -19.99964 33.08228  1.000 50.98524  ? 249 ILE A HG22 1 
ATOM   3648 H HG23 . ILE A 1 249 ? -23.11340 -21.44395 33.31124  1.000 50.98524  ? 249 ILE A HG23 1 
ATOM   3649 H HD11 . ILE A 1 249 ? -26.88643 -20.93412 31.11394  1.000 53.26980  ? 249 ILE A HD11 1 
ATOM   3650 H HD12 . ILE A 1 249 ? -25.94196 -19.65707 31.08922  1.000 53.26980  ? 249 ILE A HD12 1 
ATOM   3651 H HD13 . ILE A 1 249 ? -25.33788 -21.09745 30.79959  1.000 53.26980  ? 249 ILE A HD13 1 
ATOM   3652 N N    . LEU A 1 250 ? -23.17523 -18.02253 35.64506  1.000 37.46496  ? 250 LEU A N    1 
ATOM   3653 C CA   . LEU A 1 250 ? -21.97416 -17.44918 36.23862  1.000 38.65106  ? 250 LEU A CA   1 
ATOM   3654 C C    . LEU A 1 250 ? -21.96178 -17.55127 37.75989  1.000 40.11865  ? 250 LEU A C    1 
ATOM   3655 O O    . LEU A 1 250 ? -20.94678 -17.21013 38.37679  1.000 40.97884  ? 250 LEU A O    1 
ATOM   3656 C CB   . LEU A 1 250 ? -21.83164 -15.98551 35.80905  1.000 38.36456  ? 250 LEU A CB   1 
ATOM   3657 C CG   . LEU A 1 250 ? -21.57014 -15.72895 34.32365  1.000 35.54478  ? 250 LEU A CG   1 
ATOM   3658 C CD1  . LEU A 1 250 ? -21.79534 -14.26224 33.97079  1.000 36.08606  ? 250 LEU A CD1  1 
ATOM   3659 C CD2  . LEU A 1 250 ? -20.15719 -16.14243 33.92779  1.000 33.12462  ? 250 LEU A CD2  1 
ATOM   3660 H H    . LEU A 1 250 ? -23.78464 -17.44735 35.45169  1.000 45.69402  ? 250 LEU A H    1 
ATOM   3661 H HA   . LEU A 1 250 ? -21.19809 -17.92893 35.90931  1.000 47.11734  ? 250 LEU A HA   1 
ATOM   3662 H HB2  . LEU A 1 250 ? -22.65423 -15.52468 36.03679  1.000 46.77354  ? 250 LEU A HB2  1 
ATOM   3663 H HB3  . LEU A 1 250 ? -21.08874 -15.60006 36.29938  1.000 46.77354  ? 250 LEU A HB3  1 
ATOM   3664 H HG   . LEU A 1 250 ? -22.19758 -16.26790 33.81695  1.000 43.38981  ? 250 LEU A HG   1 
ATOM   3665 H HD11 . LEU A 1 250 ? -21.59292 -14.12870 33.03160  1.000 44.03935  ? 250 LEU A HD11 1 
ATOM   3666 H HD12 . LEU A 1 250 ? -22.72188 -14.03415 34.14515  1.000 44.03935  ? 250 LEU A HD12 1 
ATOM   3667 H HD13 . LEU A 1 250 ? -21.21112 -13.71285 34.51646  1.000 44.03935  ? 250 LEU A HD13 1 
ATOM   3668 H HD21 . LEU A 1 250 ? -20.04416 -16.00731 32.97392  1.000 40.48561  ? 250 LEU A HD21 1 
ATOM   3669 H HD22 . LEU A 1 250 ? -19.52023 -15.59826 34.41673  1.000 40.48561  ? 250 LEU A HD22 1 
ATOM   3670 H HD23 . LEU A 1 250 ? -20.02911 -17.07868 34.14672  1.000 40.48561  ? 250 LEU A HD23 1 
ATOM   3671 N N    . GLY A 1 251 ? -23.04484 -18.03014 38.36913  1.000 39.59669  ? 251 GLY A N    1 
ATOM   3672 C CA   . GLY A 1 251 ? -23.15698 -18.11034 39.80543  1.000 41.02201  ? 251 GLY A CA   1 
ATOM   3673 C C    . GLY A 1 251 ? -21.96474 -18.76164 40.47574  1.000 42.81936  ? 251 GLY A C    1 
ATOM   3674 O O    . GLY A 1 251 ? -21.36341 -18.20275 41.39818  1.000 43.17999  ? 251 GLY A O    1 
ATOM   3675 H H    . GLY A 1 251 ? -23.74039 -18.31969 37.95444  1.000 48.25210  ? 251 GLY A H    1 
ATOM   3676 H HA2  . GLY A 1 251 ? -23.25062 -17.21443 40.16526  1.000 49.96248  ? 251 GLY A HA2  1 
ATOM   3677 H HA3  . GLY A 1 251 ? -23.94677 -18.62585 40.03209  1.000 49.96248  ? 251 GLY A HA3  1 
ATOM   3678 N N    . PRO A 1 252 ? -21.60565 -19.96846 40.03441  1.000 40.50849  ? 252 PRO A N    1 
ATOM   3679 C CA   . PRO A 1 252 ? -20.42238 -20.62885 40.61804  1.000 41.38333  ? 252 PRO A CA   1 
ATOM   3680 C C    . PRO A 1 252 ? -19.18094 -19.74962 40.60820  1.000 42.11605  ? 252 PRO A C    1 
ATOM   3681 O O    . PRO A 1 252 ? -18.45728 -19.69503 41.61045  1.000 43.47282  ? 252 PRO A O    1 
ATOM   3682 C CB   . PRO A 1 252 ? -20.26127 -21.88137 39.74262  1.000 40.80147  ? 252 PRO A CB   1 
ATOM   3683 C CG   . PRO A 1 252 ? -21.65955 -22.17076 39.24513  1.000 41.78531  ? 252 PRO A CG   1 
ATOM   3684 C CD   . PRO A 1 252 ? -22.28882 -20.81304 39.03370  1.000 40.57885  ? 252 PRO A CD   1 
ATOM   3685 H HA   . PRO A 1 252 ? -20.60766 -20.90498 41.52926  1.000 50.39607  ? 252 PRO A HA   1 
ATOM   3686 H HB2  . PRO A 1 252 ? -19.65877 -21.69706 39.00512  1.000 49.69784  ? 252 PRO A HB2  1 
ATOM   3687 H HB3  . PRO A 1 252 ? -19.91974 -22.61749 40.27402  1.000 49.69784  ? 252 PRO A HB3  1 
ATOM   3688 H HG2  . PRO A 1 252 ? -21.61813 -22.66700 38.41271  1.000 50.87844  ? 252 PRO A HG2  1 
ATOM   3689 H HG3  . PRO A 1 252 ? -22.14850 -22.67954 39.91069  1.000 50.87844  ? 252 PRO A HG3  1 
ATOM   3690 H HD2  . PRO A 1 252 ? -22.12016 -20.48965 38.13489  1.000 49.43069  ? 252 PRO A HD2  1 
ATOM   3691 H HD3  . PRO A 1 252 ? -23.24372 -20.84433 39.20129  1.000 49.43069  ? 252 PRO A HD3  1 
ATOM   3692 N N    . LEU A 1 253 ? -18.91853 -19.04733 39.50315  1.000 41.75710  ? 253 LEU A N    1 
ATOM   3693 C CA   . LEU A 1 253 ? -17.77501 -18.14273 39.46638  1.000 40.27719  ? 253 LEU A CA   1 
ATOM   3694 C C    . LEU A 1 253 ? -17.98135 -16.95148 40.39344  1.000 41.75275  ? 253 LEU A C    1 
ATOM   3695 O O    . LEU A 1 253 ? -17.04922 -16.52920 41.08750  1.000 42.57297  ? 253 LEU A O    1 
ATOM   3696 C CB   . LEU A 1 253 ? -17.53005 -17.65569 38.04205  1.000 38.80047  ? 253 LEU A CB   1 
ATOM   3697 C CG   . LEU A 1 253 ? -16.91119 -18.65814 37.07407  1.000 37.32778  ? 253 LEU A CG   1 
ATOM   3698 C CD1  . LEU A 1 253 ? -16.79718 -18.04088 35.68832  1.000 34.15773  ? 253 LEU A CD1  1 
ATOM   3699 C CD2  . LEU A 1 253 ? -15.55519 -19.11368 37.57549  1.000 39.44421  ? 253 LEU A CD2  1 
ATOM   3700 H H    . LEU A 1 253 ? -19.37884 -19.07735 38.77733  1.000 50.84459  ? 253 LEU A H    1 
ATOM   3701 H HA   . LEU A 1 253 ? -16.99044 -18.63108 39.76111  1.000 49.06870  ? 253 LEU A HA   1 
ATOM   3702 H HB2  . LEU A 1 253 ? -18.38284 -17.38656 37.66625  1.000 47.29664  ? 253 LEU A HB2  1 
ATOM   3703 H HB3  . LEU A 1 253 ? -16.93096 -16.89399 38.08438  1.000 47.29664  ? 253 LEU A HB3  1 
ATOM   3704 H HG   . LEU A 1 253 ? -17.48052 -19.44101 37.01180  1.000 45.52941  ? 253 LEU A HG   1 
ATOM   3705 H HD11 . LEU A 1 253 ? -16.49174 -18.71841 35.06497  1.000 41.72535  ? 253 LEU A HD11 1 
ATOM   3706 H HD12 . LEU A 1 253 ? -17.66791 -17.71041 35.41719  1.000 41.72535  ? 253 LEU A HD12 1 
ATOM   3707 H HD13 . LEU A 1 253 ? -16.16088 -17.30942 35.71980  1.000 41.72535  ? 253 LEU A HD13 1 
ATOM   3708 H HD21 . LEU A 1 253 ? -15.09979 -19.59137 36.86463  1.000 48.06912  ? 253 LEU A HD21 1 
ATOM   3709 H HD22 . LEU A 1 253 ? -15.03728 -18.33602 37.83607  1.000 48.06912  ? 253 LEU A HD22 1 
ATOM   3710 H HD23 . LEU A 1 253 ? -15.68099 -19.69838 38.33916  1.000 48.06912  ? 253 LEU A HD23 1 
ATOM   3711 N N    . SER A 1 254 ? -19.19092 -16.38719 40.40834  1.000 43.51568  ? 254 SER A N    1 
ATOM   3712 C CA   A SER A 1 254 ? -19.46762 -15.25511 41.28690  0.710 47.36369  ? 254 SER A CA   1 
ATOM   3713 C CA   B SER A 1 254 ? -19.45173 -15.25012 41.28383  0.290 44.42901  ? 254 SER A CA   1 
ATOM   3714 C C    . SER A 1 254 ? -19.22585 -15.63151 42.74430  1.000 46.08963  ? 254 SER A C    1 
ATOM   3715 O O    . SER A 1 254 ? -18.75583 -14.81682 43.54394  1.000 46.52811  ? 254 SER A O    1 
ATOM   3716 C CB   A SER A 1 254 ? -20.90479 -14.78047 41.09321  0.710 46.65953  ? 254 SER A CB   1 
ATOM   3717 C CB   B SER A 1 254 ? -20.87265 -14.73425 41.07287  0.290 48.97564  ? 254 SER A CB   1 
ATOM   3718 O OG   A SER A 1 254 ? -21.23422 -13.77719 42.03936  0.710 46.57375  ? 254 SER A OG   1 
ATOM   3719 O OG   B SER A 1 254 ? -21.83121 -15.61977 41.62014  0.290 46.38673  ? 254 SER A OG   1 
ATOM   3720 H H    A SER A 1 254 ? -19.85756 -16.63799 39.92637  0.710 52.95489  ? 254 SER A H    1 
ATOM   3721 H H    B SER A 1 254 ? -19.86093 -16.63913 39.93167  0.290 52.95489  ? 254 SER A H    1 
ATOM   3722 H HA   A SER A 1 254 ? -18.87573 -14.52244 41.05501  0.710 57.57250  ? 254 SER A HA   1 
ATOM   3723 H HA   B SER A 1 254 ? -18.84251 -14.52982 41.05816  0.290 54.05088  ? 254 SER A HA   1 
ATOM   3724 H HB2  A SER A 1 254 ? -20.99946 -14.41550 40.19949  0.710 56.72750  ? 254 SER A HB2  1 
ATOM   3725 H HB2  B SER A 1 254 ? -20.96014 -13.87092 41.50635  0.290 59.50684  ? 254 SER A HB2  1 
ATOM   3726 H HB3  A SER A 1 254 ? -21.50485 -15.53371 41.20924  0.710 56.72750  ? 254 SER A HB3  1 
ATOM   3727 H HB3  B SER A 1 254 ? -21.03565 -14.64549 40.12079  0.290 59.50684  ? 254 SER A HB3  1 
ATOM   3728 H HG   A SER A 1 254 ? -20.86783 -13.05148 41.82793  0.710 56.62457  ? 254 SER A HG   1 
ATOM   3729 H HG   B SER A 1 254 ? -21.75665 -16.37809 41.26660  0.290 56.40014  ? 254 SER A HG   1 
ATOM   3730 N N    . ALA A 1 255 ? -19.55257 -16.87402 43.11222  1.000 44.07861  ? 255 ALA A N    1 
ATOM   3731 C CA   . ALA A 1 255 ? -19.37348 -17.30511 44.49652  1.000 47.59174  ? 255 ALA A CA   1 
ATOM   3732 C C    . ALA A 1 255 ? -17.90097 -17.50258 44.83264  1.000 48.38956  ? 255 ALA A C    1 
ATOM   3733 O O    . ALA A 1 255 ? -17.45522 -17.14371 45.92891  1.000 47.07391  ? 255 ALA A O    1 
ATOM   3734 C CB   . ALA A 1 255 ? -20.15345 -18.59590 44.75057  1.000 47.82178  ? 255 ALA A CB   1 
ATOM   3735 H H    . ALA A 1 255 ? -19.87407 -17.47506 42.58783  1.000 53.63040  ? 255 ALA A H    1 
ATOM   3736 H HA   . ALA A 1 255 ? -19.72646 -16.61654 45.08148  1.000 57.84615  ? 255 ALA A HA   1 
ATOM   3737 H HB1  . ALA A 1 255 ? -20.01707 -18.87142 45.67056  1.000 58.12221  ? 255 ALA A HB1  1 
ATOM   3738 H HB2  . ALA A 1 255 ? -21.09603 -18.43199 44.59063  1.000 58.12221  ? 255 ALA A HB2  1 
ATOM   3739 H HB3  . ALA A 1 255 ? -19.83042 -19.28389 44.14789  1.000 58.12221  ? 255 ALA A HB3  1 
ATOM   3740 N N    . GLN A 1 256 ? -17.13072 -18.07404 43.90439  1.000 47.56525  ? 256 GLN A N    1 
ATOM   3741 C CA   . GLN A 1 256 ? -15.72586 -18.35539 44.17033  1.000 48.70401  ? 256 GLN A CA   1 
ATOM   3742 C C    . GLN A 1 256 ? -14.89919 -17.08574 44.32837  1.000 49.58188  ? 256 GLN A C    1 
ATOM   3743 O O    . GLN A 1 256 ? -13.83759 -17.13020 44.96147  1.000 52.62192  ? 256 GLN A O    1 
ATOM   3744 C CB   . GLN A 1 256 ? -15.15149 -19.21856 43.04438  1.000 51.73244  ? 256 GLN A CB   1 
ATOM   3745 C CG   . GLN A 1 256 ? -13.79432 -19.82870 43.34927  1.000 58.60876  ? 256 GLN A CG   1 
ATOM   3746 C CD   . GLN A 1 256 ? -13.26260 -20.68919 42.21316  1.000 67.02195  ? 256 GLN A CD   1 
ATOM   3747 O OE1  . GLN A 1 256 ? -14.00315 -21.07638 41.30785  1.000 67.82064  ? 256 GLN A OE1  1 
ATOM   3748 N NE2  . GLN A 1 256 ? -11.96923 -20.98876 42.25657  1.000 76.88090  ? 256 GLN A NE2  1 
ATOM   3749 H H    . GLN A 1 256 ? -17.39773 -18.30549 43.12034  1.000 57.81437  ? 256 GLN A H    1 
ATOM   3750 H HA   . GLN A 1 256 ? -15.65670 -18.85414 44.99941  1.000 59.18088  ? 256 GLN A HA   1 
ATOM   3751 H HB2  . GLN A 1 256 ? -15.76746 -19.94694 42.86844  1.000 62.81500  ? 256 GLN A HB2  1 
ATOM   3752 H HB3  . GLN A 1 256 ? -15.05392 -18.66784 42.25186  1.000 62.81500  ? 256 GLN A HB3  1 
ATOM   3753 H HG2  . GLN A 1 256 ? -13.15639 -19.11549 43.50824  1.000 71.06657  ? 256 GLN A HG2  1 
ATOM   3754 H HG3  . GLN A 1 256 ? -13.86999 -20.38806 44.13812  1.000 71.06657  ? 256 GLN A HG3  1 
ATOM   3755 H HE21 . GLN A 1 256 ? -11.48215 -20.69879 42.90330  1.000 92.99315  ? 256 GLN A HE21 1 
ATOM   3756 H HE22 . GLN A 1 256 ? -11.61894 -21.47269 41.63794  1.000 92.99315  ? 256 GLN A HE22 1 
ATOM   3757 N N    . THR A 1 257 ? -15.36585 -15.95757 43.78619  1.000 44.31880  ? 257 THR A N    1 
ATOM   3758 C CA   . THR A 1 257 ? -14.61609 -14.71078 43.81368  1.000 43.44760  ? 257 THR A CA   1 
ATOM   3759 C C    . THR A 1 257 ? -15.23330 -13.64279 44.70497  1.000 45.46837  ? 257 THR A C    1 
ATOM   3760 O O    . THR A 1 257 ? -14.59553 -12.60935 44.93573  1.000 42.55323  ? 257 THR A O    1 
ATOM   3761 C CB   . THR A 1 257 ? -14.49042 -14.13688 42.39280  1.000 44.51080  ? 257 THR A CB   1 
ATOM   3762 O OG1  . THR A 1 257 ? -15.80110 -13.84594 41.88580  1.000 44.55370  ? 257 THR A OG1  1 
ATOM   3763 C CG2  . THR A 1 257 ? -13.79733 -15.11921 41.46561  1.000 42.34920  ? 257 THR A CG2  1 
ATOM   3764 H H    . THR A 1 257 ? -16.12720 -15.89333 43.39145  1.000 53.91862  ? 257 THR A H    1 
ATOM   3765 H HA   . THR A 1 257 ? -13.72688 -14.90372 44.14982  1.000 52.87318  ? 257 THR A HA   1 
ATOM   3766 H HB   . THR A 1 257 ? -13.95787 -13.32653 42.41788  1.000 54.14903  ? 257 THR A HB   1 
ATOM   3767 H HG1  . THR A 1 257 ? -16.24247 -14.55617 41.80603  1.000 54.20051  ? 257 THR A HG1  1 
ATOM   3768 H HG21 . THR A 1 257 ? -13.61862 -14.69839 40.61011  1.000 51.55511  ? 257 THR A HG21 1 
ATOM   3769 H HG22 . THR A 1 257 ? -12.95757 -15.40789 41.85595  1.000 51.55511  ? 257 THR A HG22 1 
ATOM   3770 H HG23 . THR A 1 257 ? -14.36143 -15.89531 41.32294  1.000 51.55511  ? 257 THR A HG23 1 
ATOM   3771 N N    . GLY A 1 258 ? -16.44992 -13.85152 45.19612  1.000 47.34113  ? 258 GLY A N    1 
ATOM   3772 C CA   . GLY A 1 258 ? -17.11968 -12.81555 45.95632  1.000 45.06484  ? 258 GLY A CA   1 
ATOM   3773 C C    . GLY A 1 258 ? -17.37638 -11.55406 45.16755  1.000 45.37624  ? 258 GLY A C    1 
ATOM   3774 O O    . GLY A 1 258 ? -17.36467 -10.45788 45.73996  1.000 44.45917  ? 258 GLY A O    1 
ATOM   3775 H H    . GLY A 1 258 ? -16.90113 -14.57760 45.10219  1.000 57.54542  ? 258 GLY A H    1 
ATOM   3776 H HA2  . GLY A 1 258 ? -17.97365 -13.15456 46.26728  1.000 54.81388  ? 258 GLY A HA2  1 
ATOM   3777 H HA3  . GLY A 1 258 ? -16.57336 -12.58422 46.72373  1.000 54.81388  ? 258 GLY A HA3  1 
ATOM   3778 N N    . ILE A 1 259 ? -17.60055 -11.67446 43.86208  1.000 43.71556  ? 259 ILE A N    1 
ATOM   3779 C CA   . ILE A 1 259 ? -17.93423 -10.53843 43.01139  1.000 46.00954  ? 259 ILE A CA   1 
ATOM   3780 C C    . ILE A 1 259 ? -19.27019 -10.82579 42.34387  1.000 46.60941  ? 259 ILE A C    1 
ATOM   3781 O O    . ILE A 1 259 ? -19.39099 -11.78890 41.57524  1.000 46.00708  ? 259 ILE A O    1 
ATOM   3782 C CB   . ILE A 1 259 ? -16.86075 -10.26673 41.94747  1.000 44.28384  ? 259 ILE A CB   1 
ATOM   3783 C CG1  . ILE A 1 259 ? -15.52206 -9.94716  42.60083  1.000 46.18189  ? 259 ILE A CG1  1 
ATOM   3784 C CG2  . ILE A 1 259 ? -17.30700 -9.12264  41.04488  1.000 44.24136  ? 259 ILE A CG2  1 
ATOM   3785 C CD1  . ILE A 1 259 ? -14.34875 -10.10996 41.66068  1.000 45.91982  ? 259 ILE A CD1  1 
ATOM   3786 H H    . ILE A 1 259 ? -17.56398 -12.42174 43.43802  1.000 53.19474  ? 259 ILE A H    1 
ATOM   3787 H HA   . ILE A 1 259 ? -18.02145 -9.75032  43.57012  1.000 55.94751  ? 259 ILE A HA   1 
ATOM   3788 H HB   . ILE A 1 259 ? -16.74680 -11.06643 41.41044  1.000 53.87667  ? 259 ILE A HB   1 
ATOM   3789 H HG12 . ILE A 1 259 ? -15.53368 -9.02703  42.90764  1.000 56.15434  ? 259 ILE A HG12 1 
ATOM   3790 H HG13 . ILE A 1 259 ? -15.38813 -10.54576 43.35226  1.000 56.15434  ? 259 ILE A HG13 1 
ATOM   3791 H HG21 . ILE A 1 259 ? -16.54757 -8.81560  40.52537  1.000 53.82570  ? 259 ILE A HG21 1 
ATOM   3792 H HG22 . ILE A 1 259 ? -18.00568 -9.44180  40.45252  1.000 53.82570  ? 259 ILE A HG22 1 
ATOM   3793 H HG23 . ILE A 1 259 ? -17.64515 -8.39933  41.59567  1.000 53.82570  ? 259 ILE A HG23 1 
ATOM   3794 H HD11 . ILE A 1 259 ? -13.52578 -9.97841  42.15699  1.000 55.83986  ? 259 ILE A HD11 1 
ATOM   3795 H HD12 . ILE A 1 259 ? -14.36816 -11.00326 41.28315  1.000 55.83986  ? 259 ILE A HD12 1 
ATOM   3796 H HD13 . ILE A 1 259 ? -14.41727 -9.45018  40.95294  1.000 55.83986  ? 259 ILE A HD13 1 
ATOM   3797 N N    . ALA A 1 260 ? -20.26330 -9.98476  42.61822  1.000 46.84911  ? 260 ALA A N    1 
ATOM   3798 C CA   . ALA A 1 260 ? -21.57209 -10.17070 42.00970  1.000 49.06300  ? 260 ALA A CA   1 
ATOM   3799 C C    . ALA A 1 260 ? -21.46714 -10.03795 40.49651  1.000 46.45838  ? 260 ALA A C    1 
ATOM   3800 O O    . ALA A 1 260 ? -20.70286 -9.21888  39.97785  1.000 48.37499  ? 260 ALA A O    1 
ATOM   3801 C CB   . ALA A 1 260 ? -22.56863 -9.15447  42.56320  1.000 60.86941  ? 260 ALA A CB   1 
ATOM   3802 H H    . ALA A 1 260 ? -20.20461 -9.30843  43.14617  1.000 56.95500  ? 260 ALA A H    1 
ATOM   3803 H HA   . ALA A 1 260 ? -21.90560 -11.05673 42.22095  1.000 59.61167  ? 260 ALA A HA   1 
ATOM   3804 H HB1  . ALA A 1 260 ? -23.42486 -9.28104  42.12532  1.000 73.77936  ? 260 ALA A HB1  1 
ATOM   3805 H HB2  . ALA A 1 260 ? -22.66225 -9.29219  43.51880  1.000 73.77936  ? 260 ALA A HB2  1 
ATOM   3806 H HB3  . ALA A 1 260 ? -22.23700 -8.25975  42.38887  1.000 73.77936  ? 260 ALA A HB3  1 
ATOM   3807 N N    . VAL A 1 261 ? -22.23984 -10.86161 39.78834  1.000 46.02447  ? 261 VAL A N    1 
ATOM   3808 C CA   . VAL A 1 261 ? -22.24582 -10.81427 38.32931  1.000 45.68791  ? 261 VAL A CA   1 
ATOM   3809 C C    . VAL A 1 261 ? -22.44955 -9.38500  37.84440  1.000 48.87411  ? 261 VAL A C    1 
ATOM   3810 O O    . VAL A 1 261 ? -21.68159 -8.87159  37.02123  1.000 47.06557  ? 261 VAL A O    1 
ATOM   3811 C CB   . VAL A 1 261 ? -23.32785 -11.75714 37.77366  1.000 43.32406  ? 261 VAL A CB   1 
ATOM   3812 C CG1  . VAL A 1 261 ? -23.53334 -11.51372 36.29139  1.000 43.93270  ? 261 VAL A CG1  1 
ATOM   3813 C CG2  . VAL A 1 261 ? -22.95408 -13.21400 38.04363  1.000 43.00588  ? 261 VAL A CG2  1 
ATOM   3814 H H    . VAL A 1 261 ? -22.76554 -11.45228 40.12650  1.000 55.96543  ? 261 VAL A H    1 
ATOM   3815 H HA   . VAL A 1 261 ? -21.38310 -11.11684 38.00518  1.000 55.56156  ? 261 VAL A HA   1 
ATOM   3816 H HB   . VAL A 1 261 ? -24.16793 -11.57615 38.22355  1.000 52.72494  ? 261 VAL A HB   1 
ATOM   3817 H HG11 . VAL A 1 261 ? -23.96760 -12.28843 35.90136  1.000 53.45530  ? 261 VAL A HG11 1 
ATOM   3818 H HG12 . VAL A 1 261 ? -24.09059 -10.72839 36.17460  1.000 53.45530  ? 261 VAL A HG12 1 
ATOM   3819 H HG13 . VAL A 1 261 ? -22.67023 -11.37221 35.87196  1.000 53.45530  ? 261 VAL A HG13 1 
ATOM   3820 H HG21 . VAL A 1 261 ? -23.59086 -13.79180 37.59467  1.000 52.34313  ? 261 VAL A HG21 1 
ATOM   3821 H HG22 . VAL A 1 261 ? -22.06074 -13.37905 37.70364  1.000 52.34313  ? 261 VAL A HG22 1 
ATOM   3822 H HG23 . VAL A 1 261 ? -22.97892 -13.37440 38.99995  1.000 52.34313  ? 261 VAL A HG23 1 
ATOM   3823 N N    . LEU A 1 262 ? -23.48673 -8.71507  38.35238  1.000 49.50363  ? 262 LEU A N    1 
ATOM   3824 C CA   . LEU A 1 262 ? -23.78843 -7.36862  37.88144  1.000 50.87310  ? 262 LEU A CA   1 
ATOM   3825 C C    . LEU A 1 262 ? -22.67957 -6.37688  38.20916  1.000 49.85003  ? 262 LEU A C    1 
ATOM   3826 O O    . LEU A 1 262 ? -22.54732 -5.37047  37.50139  1.000 51.55636  ? 262 LEU A O    1 
ATOM   3827 C CB   . LEU A 1 262 ? -25.12431 -6.89568  38.45860  1.000 52.34287  ? 262 LEU A CB   1 
ATOM   3828 C CG   . LEU A 1 262 ? -26.35953 -7.55525  37.84612  1.000 54.50614  ? 262 LEU A CG   1 
ATOM   3829 C CD1  . LEU A 1 262 ? -27.62534 -7.08161  38.55268  1.000 58.21461  ? 262 LEU A CD1  1 
ATOM   3830 C CD2  . LEU A 1 262 ? -26.46391 -7.28353  36.34909  1.000 55.20509  ? 262 LEU A CD2  1 
ATOM   3831 H H    . LEU A 1 262 ? -24.01879 -9.01408  38.95827  1.000 60.14043  ? 262 LEU A H    1 
ATOM   3832 H HA   . LEU A 1 262 ? -23.88078 -7.38818  36.91604  1.000 61.78379  ? 262 LEU A HA   1 
ATOM   3833 H HB2  . LEU A 1 262 ? -25.13250 -7.08695  39.40952  1.000 63.54751  ? 262 LEU A HB2  1 
ATOM   3834 H HB3  . LEU A 1 262 ? -25.20068 -5.93990  38.31178  1.000 63.54751  ? 262 LEU A HB3  1 
ATOM   3835 H HG   . LEU A 1 262 ? -26.27446 -8.51432  37.96383  1.000 66.14344  ? 262 LEU A HG   1 
ATOM   3836 H HD11 . LEU A 1 262 ? -28.38687 -7.56234  38.19229  1.000 70.59360  ? 262 LEU A HD11 1 
ATOM   3837 H HD12 . LEU A 1 262 ? -27.54180 -7.25872  39.50271  1.000 70.59360  ? 262 LEU A HD12 1 
ATOM   3838 H HD13 . LEU A 1 262 ? -27.73370 -6.12954  38.40196  1.000 70.59360  ? 262 LEU A HD13 1 
ATOM   3839 H HD21 . LEU A 1 262 ? -27.36894 -7.47317  36.05606  1.000 66.98218  ? 262 LEU A HD21 1 
ATOM   3840 H HD22 . LEU A 1 262 ? -26.25025 -6.35232  36.18150  1.000 66.98218  ? 262 LEU A HD22 1 
ATOM   3841 H HD23 . LEU A 1 262 ? -25.83739 -7.85631  35.87973  1.000 66.98218  ? 262 LEU A HD23 1 
ATOM   3842 N N    . ASP A 1 263 ? -21.88190 -6.63873  39.24548  1.000 50.57977  ? 263 ASP A N    1 
ATOM   3843 C CA   . ASP A 1 263 ? -20.69120 -5.82928  39.47069  1.000 50.89614  ? 263 ASP A CA   1 
ATOM   3844 C C    . ASP A 1 263 ? -19.64067 -6.10502  38.40304  1.000 50.92474  ? 263 ASP A C    1 
ATOM   3845 O O    . ASP A 1 263 ? -18.96433 -5.18252  37.93442  1.000 48.50132  ? 263 ASP A O    1 
ATOM   3846 C CB   . ASP A 1 263 ? -20.11256 -6.10331  40.85679  1.000 51.85189  ? 263 ASP A CB   1 
ATOM   3847 C CG   . ASP A 1 263 ? -20.96978 -5.54206  41.97079  1.000 57.71056  ? 263 ASP A CG   1 
ATOM   3848 O OD1  . ASP A 1 263 ? -21.54057 -4.43948  41.79868  1.000 59.95693  ? 263 ASP A OD1  1 
ATOM   3849 O OD2  . ASP A 1 263 ? -21.07017 -6.20096  43.02679  1.000 66.41712  ? 263 ASP A OD2  1 
ATOM   3850 H H    . ASP A 1 263 ? -22.00674 -7.26658  39.81979  1.000 61.43179  ? 263 ASP A H    1 
ATOM   3851 H HA   . ASP A 1 263 ? -20.94127 -4.89291  39.43099  1.000 61.81144  ? 263 ASP A HA   1 
ATOM   3852 H HB2  . ASP A 1 263 ? -20.04263 -7.06209  40.98620  1.000 62.95834  ? 263 ASP A HB2  1 
ATOM   3853 H HB3  . ASP A 1 263 ? -19.23479 -5.69523  40.91918  1.000 62.95834  ? 263 ASP A HB3  1 
ATOM   3854 N N    . MET A 1 264 ? -19.47885 -7.37252  38.01890  1.000 46.79518  ? 264 MET A N    1 
ATOM   3855 C CA   . MET A 1 264 ? -18.58219 -7.68966  36.91507  1.000 45.82850  ? 264 MET A CA   1 
ATOM   3856 C C    . MET A 1 264 ? -19.07897 -7.05356  35.62178  1.000 44.24940  ? 264 MET A C    1 
ATOM   3857 O O    . MET A 1 264 ? -18.28538 -6.50715  34.84669  1.000 46.95679  ? 264 MET A O    1 
ATOM   3858 C CB   . MET A 1 264 ? -18.45321 -9.20375  36.76327  1.000 41.78637  ? 264 MET A CB   1 
ATOM   3859 C CG   . MET A 1 264 ? -17.34550 -9.62283  35.81654  1.000 38.46824  ? 264 MET A CG   1 
ATOM   3860 S SD   . MET A 1 264 ? -15.71955 -9.11255  36.40846  1.000 38.24836  ? 264 MET A SD   1 
ATOM   3861 C CE   . MET A 1 264 ? -15.33881 -10.44867 37.53549  1.000 37.71805  ? 264 MET A CE   1 
ATOM   3862 H H    . MET A 1 264 ? -19.86925 -8.05119  38.37470  1.000 56.89029  ? 264 MET A H    1 
ATOM   3863 H HA   . MET A 1 264 ? -17.69837 -7.34385  37.11553  1.000 55.73027  ? 264 MET A HA   1 
ATOM   3864 H HB2  . MET A 1 264 ? -18.26384 -9.59047  37.63246  1.000 50.87971  ? 264 MET A HB2  1 
ATOM   3865 H HB3  . MET A 1 264 ? -19.28854 -9.55603  36.41828  1.000 50.87971  ? 264 MET A HB3  1 
ATOM   3866 H HG2  . MET A 1 264 ? -17.34742 -10.58908 35.73146  1.000 46.89795  ? 264 MET A HG2  1 
ATOM   3867 H HG3  . MET A 1 264 ? -17.49474 -9.21319  34.95004  1.000 46.89795  ? 264 MET A HG3  1 
ATOM   3868 H HE1  . MET A 1 264 ? -14.48792 -10.26723 37.96441  1.000 45.99773  ? 264 MET A HE1  1 
ATOM   3869 H HE2  . MET A 1 264 ? -16.03985 -10.50801 38.20325  1.000 45.99773  ? 264 MET A HE2  1 
ATOM   3870 H HE3  . MET A 1 264 ? -15.28700 -11.27836 37.03565  1.000 45.99773  ? 264 MET A HE3  1 
ATOM   3871 N N    . CYS A 1 265 ? -20.39406 -7.09623  35.37990  1.000 45.15363  ? 265 CYS A N    1 
ATOM   3872 C CA   . CYS A 1 265 ? -20.93990 -6.47081  34.17983  1.000 48.41658  ? 265 CYS A CA   1 
ATOM   3873 C C    . CYS A 1 265 ? -20.60240 -4.98492  34.13357  1.000 48.68582  ? 265 CYS A C    1 
ATOM   3874 O O    . CYS A 1 265 ? -20.33079 -4.43316  33.06137  1.000 49.55900  ? 265 CYS A O    1 
ATOM   3875 C CB   . CYS A 1 265 ? -22.45467 -6.65988  34.12239  1.000 49.44173  ? 265 CYS A CB   1 
ATOM   3876 S SG   . CYS A 1 265 ? -23.00806 -8.35582  33.89094  1.000 50.86377  ? 265 CYS A SG   1 
ATOM   3877 H H    . CYS A 1 265 ? -20.97738 -7.47412  35.88640  1.000 54.92042  ? 265 CYS A H    1 
ATOM   3878 H HA   . CYS A 1 265 ? -20.54958 -6.90383  33.40456  1.000 58.83596  ? 265 CYS A HA   1 
ATOM   3879 H HB2  . CYS A 1 265 ? -22.83442 -6.34237  34.95658  1.000 60.06614  ? 265 CYS A HB2  1 
ATOM   3880 H HB3  . CYS A 1 265 ? -22.80011 -6.13853  33.38093  1.000 60.06614  ? 265 CYS A HB3  1 
ATOM   3881 H HG   . CYS A 1 265 ? -22.55931 -9.03679  34.77123  1.000 61.77259  ? 265 CYS A HG   1 
ATOM   3882 N N    . ALA A 1 266 ? -20.63085 -4.31659  35.28854  1.000 51.32891  ? 266 ALA A N    1 
ATOM   3883 C CA   . ALA A 1 266 ? -20.30700 -2.89491  35.32645  1.000 51.32998  ? 266 ALA A CA   1 
ATOM   3884 C C    . ALA A 1 266 ? -18.84408 -2.65726  34.97400  1.000 51.31148  ? 266 ALA A C    1 
ATOM   3885 O O    . ALA A 1 266 ? -18.51274 -1.66783  34.31148  1.000 51.94015  ? 266 ALA A O    1 
ATOM   3886 C CB   . ALA A 1 266 ? -20.63244 -2.32096  36.70492  1.000 57.17348  ? 266 ALA A CB   1 
ATOM   3887 H H    . ALA A 1 266 ? -20.83156 -4.65917  36.05140  1.000 62.33076  ? 266 ALA A H    1 
ATOM   3888 H HA   . ALA A 1 266 ? -20.85258 -2.42889  34.67371  1.000 62.33204  ? 266 ALA A HA   1 
ATOM   3889 H HB1  . ALA A 1 266 ? -20.42744 -1.37288  36.70867  1.000 69.34425  ? 266 ALA A HB1  1 
ATOM   3890 H HB2  . ALA A 1 266 ? -21.57520 -2.45626  36.88879  1.000 69.34425  ? 266 ALA A HB2  1 
ATOM   3891 H HB3  . ALA A 1 266 ? -20.09644 -2.77793  37.37184  1.000 69.34425  ? 266 ALA A HB3  1 
ATOM   3892 N N    . SER A 1 267 ? -17.95345 -3.55071  35.41211  1.000 52.14285  ? 267 SER A N    1 
ATOM   3893 C CA   . SER A 1 267 ? -16.55655 -3.46072  35.00149  1.000 52.37360  ? 267 SER A CA   1 
ATOM   3894 C C    . SER A 1 267 ? -16.42185 -3.60555  33.49042  1.000 50.10648  ? 267 SER A C    1 
ATOM   3895 O O    . SER A 1 267 ? -15.66319 -2.86636  32.85216  1.000 50.62966  ? 267 SER A O    1 
ATOM   3896 C CB   . SER A 1 267 ? -15.72928 -4.53136  35.71418  1.000 50.08344  ? 267 SER A CB   1 
ATOM   3897 O OG   . SER A 1 267 ? -15.70751 -4.32006  37.11476  1.000 52.43114  ? 267 SER A OG   1 
ATOM   3898 H H    . SER A 1 267 ? -18.13131 -4.20680  35.93891  1.000 63.30749  ? 267 SER A H    1 
ATOM   3899 H HA   . SER A 1 267 ? -16.20953 -2.59189  35.25766  1.000 63.58439  ? 267 SER A HA   1 
ATOM   3900 H HB2  . SER A 1 267 ? -16.11986 -5.40083  35.53426  1.000 60.83620  ? 267 SER A HB2  1 
ATOM   3901 H HB3  . SER A 1 267 ? -14.81987 -4.50023  35.37819  1.000 60.83620  ? 267 SER A HB3  1 
ATOM   3902 H HG   . SER A 1 267 ? -15.29717 -4.94750  37.49362  1.000 63.65344  ? 267 SER A HG   1 
ATOM   3903 N N    . LEU A 1 268 ? -17.15034 -4.56058  32.90267  1.000 49.41733  ? 268 LEU A N    1 
ATOM   3904 C CA   . LEU A 1 268 ? -17.09161 -4.75721  31.45684  1.000 47.11710  ? 268 LEU A CA   1 
ATOM   3905 C C    . LEU A 1 268 ? -17.62081 -3.53822  30.71506  1.000 47.29120  ? 268 LEU A C    1 
ATOM   3906 O O    . LEU A 1 268 ? -17.03461 -3.11100  29.71237  1.000 48.43866  ? 268 LEU A O    1 
ATOM   3907 C CB   . LEU A 1 268 ? -17.88919 -6.00156  31.07503  1.000 44.24447  ? 268 LEU A CB   1 
ATOM   3908 C CG   . LEU A 1 268 ? -17.96900 -6.34538  29.58982  1.000 42.37033  ? 268 LEU A CG   1 
ATOM   3909 C CD1  . LEU A 1 268 ? -16.58468 -6.49538  28.99759  1.000 39.99599  ? 268 LEU A CD1  1 
ATOM   3910 C CD2  . LEU A 1 268 ? -18.78117 -7.62189  29.39277  1.000 39.32587  ? 268 LEU A CD2  1 
ATOM   3911 H H    . LEU A 1 268 ? -17.67874 -5.09964  33.31475  1.000 60.03686  ? 268 LEU A H    1 
ATOM   3912 H HA   . LEU A 1 268 ? -16.16821 -4.89240  31.19232  1.000 57.27658  ? 268 LEU A HA   1 
ATOM   3913 H HB2  . LEU A 1 268 ? -17.48554 -6.76296  31.52028  1.000 53.82943  ? 268 LEU A HB2  1 
ATOM   3914 H HB3  . LEU A 1 268 ? -18.79972 -5.87954  31.38639  1.000 53.82943  ? 268 LEU A HB3  1 
ATOM   3915 H HG   . LEU A 1 268 ? -18.41295 -5.62316  29.11843  1.000 51.58047  ? 268 LEU A HG   1 
ATOM   3916 H HD11 . LEU A 1 268 ? -16.66597 -6.75345  28.06609  1.000 48.73126  ? 268 LEU A HD11 1 
ATOM   3917 H HD12 . LEU A 1 268 ? -16.11817 -5.64772  29.06649  1.000 48.73126  ? 268 LEU A HD12 1 
ATOM   3918 H HD13 . LEU A 1 268 ? -16.10316 -7.17888  29.48939  1.000 48.73126  ? 268 LEU A HD13 1 
ATOM   3919 H HD21 . LEU A 1 268 ? -18.82360 -7.82613  28.44546  1.000 47.92711  ? 268 LEU A HD21 1 
ATOM   3920 H HD22 . LEU A 1 268 ? -18.34857 -8.34804  29.86865  1.000 47.92711  ? 268 LEU A HD22 1 
ATOM   3921 H HD23 . LEU A 1 268 ? -19.67564 -7.48414  29.74184  1.000 47.92711  ? 268 LEU A HD23 1 
ATOM   3922 N N    . LYS A 1 269 ? -18.73723 -2.98103  31.18917  1.000 48.80374  ? 269 LYS A N    1 
ATOM   3923 C CA   . LYS A 1 269 ? -19.24142 -1.71368  30.66852  1.000 53.19843  ? 269 LYS A CA   1 
ATOM   3924 C C    . LYS A 1 269 ? -18.11920 -0.69210  30.54496  1.000 53.85459  ? 269 LYS A C    1 
ATOM   3925 O O    . LYS A 1 269 ? -17.91478 -0.09866  29.47845  1.000 53.99263  ? 269 LYS A O    1 
ATOM   3926 C CB   . LYS A 1 269 ? -20.35127 -1.20150  31.59290  1.000 54.10162  ? 269 LYS A CB   1 
ATOM   3927 C CG   . LYS A 1 269 ? -21.16702 -0.02917  31.07039  1.000 57.94077  ? 269 LYS A CG   1 
ATOM   3928 C CD   . LYS A 1 269 ? -22.60170 -0.05741  31.61704  1.000 61.68158  ? 269 LYS A CD   1 
ATOM   3929 C CE   . LYS A 1 269 ? -22.79719 0.83344   32.84347  1.000 81.42429  ? 269 LYS A CE   1 
ATOM   3930 N NZ   . LYS A 1 269 ? -24.20778 0.78945   33.34225  1.000 69.83981  ? 269 LYS A NZ   1 
ATOM   3931 H H    . LYS A 1 269 ? -19.22190 -3.31866  31.81423  1.000 59.30056  ? 269 LYS A H    1 
ATOM   3932 H HA   . LYS A 1 269 ? -19.61606 -1.84784  29.78390  1.000 64.57418  ? 269 LYS A HA   1 
ATOM   3933 H HB2  . LYS A 1 269 ? -20.96984 -1.93057  31.75641  1.000 65.65801  ? 269 LYS A HB2  1 
ATOM   3934 H HB3  . LYS A 1 269 ? -19.94443 -0.91830  32.42668  1.000 65.65801  ? 269 LYS A HB3  1 
ATOM   3935 H HG2  . LYS A 1 269 ? -20.75071 0.80172   31.34824  1.000 70.26499  ? 269 LYS A HG2  1 
ATOM   3936 H HG3  . LYS A 1 269 ? -21.20829 -0.07204  30.10221  1.000 70.26499  ? 269 LYS A HG3  1 
ATOM   3937 H HD2  . LYS A 1 269 ? -23.20803 0.25104   30.92558  1.000 74.75397  ? 269 LYS A HD2  1 
ATOM   3938 H HD3  . LYS A 1 269 ? -22.82367 -0.96676  31.87144  1.000 74.75397  ? 269 LYS A HD3  1 
ATOM   3939 H HE2  . LYS A 1 269 ? -22.21327 0.52980   33.55603  1.000 98.44522  ? 269 LYS A HE2  1 
ATOM   3940 H HE3  . LYS A 1 269 ? -22.58597 1.75084   32.60968  1.000 98.44522  ? 269 LYS A HE3  1 
ATOM   3941 H HZ1  . LYS A 1 269 ? -24.52427 1.61624   33.43360  1.000 84.54384  ? 269 LYS A HZ1  1 
ATOM   3942 H HZ2  . LYS A 1 269 ? -24.72074 0.34585   32.76589  1.000 84.54384  ? 269 LYS A HZ2  1 
ATOM   3943 H HZ3  . LYS A 1 269 ? -24.23890 0.37940   34.13155  1.000 84.54384  ? 269 LYS A HZ3  1 
ATOM   3944 N N    . GLU A 1 270 ? -17.37246 -0.48095  31.63078  1.000 55.74191  ? 270 GLU A N    1 
ATOM   3945 C CA   . GLU A 1 270 ? -16.27178 0.47559   31.60432  1.000 59.19934  ? 270 GLU A CA   1 
ATOM   3946 C C    . GLU A 1 270 ? -15.23008 0.08949   30.56253  1.000 57.17787  ? 270 GLU A C    1 
ATOM   3947 O O    . GLU A 1 270 ? -14.73006 0.94673   29.82491  1.000 58.20158  ? 270 GLU A O    1 
ATOM   3948 C CB   . GLU A 1 270 ? -15.63354 0.56214   32.98971  1.000 69.10771  ? 270 GLU A CB   1 
ATOM   3949 C CG   . GLU A 1 270 ? -14.83174 1.82484   33.24009  1.000 76.22761  ? 270 GLU A CG   1 
ATOM   3950 C CD   . GLU A 1 270 ? -15.70215 2.98656   33.67679  1.000 95.87913  ? 270 GLU A CD   1 
ATOM   3951 O OE1  . GLU A 1 270 ? -16.93910 2.89934   33.52186  1.000 82.52244  ? 270 GLU A OE1  1 
ATOM   3952 O OE2  . GLU A 1 270 ? -15.14914 3.98498   34.18396  1.000 129.13925 ? 270 GLU A OE2  1 
ATOM   3953 H H    . GLU A 1 270 ? -17.48261 -0.87555  32.38692  1.000 67.62636  ? 270 GLU A H    1 
ATOM   3954 H HA   . GLU A 1 270 ? -16.61884 1.35075   31.37077  1.000 71.77527  ? 270 GLU A HA   1 
ATOM   3955 H HB2  . GLU A 1 270 ? -16.33748 0.52611   33.65610  1.000 83.66532  ? 270 GLU A HB2  1 
ATOM   3956 H HB3  . GLU A 1 270 ? -15.03328 -0.19179  33.10012  1.000 83.66532  ? 270 GLU A HB3  1 
ATOM   3957 H HG2  . GLU A 1 270 ? -14.18268 1.65481   33.94060  1.000 92.20921  ? 270 GLU A HG2  1 
ATOM   3958 H HG3  . GLU A 1 270 ? -14.37758 2.07973   32.42176  1.000 92.20921  ? 270 GLU A HG3  1 
ATOM   3959 N N    . LEU A 1 271 ? -14.88600 -1.19765  30.49096  1.000 53.24310  ? 271 LEU A N    1 
ATOM   3960 C CA   . LEU A 1 271 ? -13.90205 -1.64555  29.51198  1.000 51.91580  ? 271 LEU A CA   1 
ATOM   3961 C C    . LEU A 1 271 ? -14.38219 -1.39195  28.08910  1.000 50.90863  ? 271 LEU A C    1 
ATOM   3962 O O    . LEU A 1 271 ? -13.58877 -1.02643  27.21456  1.000 52.71257  ? 271 LEU A O    1 
ATOM   3963 C CB   . LEU A 1 271 ? -13.60395 -3.13024  29.71479  1.000 49.00981  ? 271 LEU A CB   1 
ATOM   3964 C CG   . LEU A 1 271 ? -12.73964 -3.50186  30.91541  1.000 49.42477  ? 271 LEU A CG   1 
ATOM   3965 C CD1  . LEU A 1 271 ? -13.01316 -4.94284  31.31737  1.000 46.14473  ? 271 LEU A CD1  1 
ATOM   3966 C CD2  . LEU A 1 271 ? -11.26806 -3.30864  30.60672  1.000 51.54571  ? 271 LEU A CD2  1 
ATOM   3967 H H    . LEU A 1 271 ? -15.20362 -1.82114  30.99093  1.000 64.62779  ? 271 LEU A H    1 
ATOM   3968 H HA   . LEU A 1 271 ? -13.08013 -1.14818  29.64604  1.000 63.03502  ? 271 LEU A HA   1 
ATOM   3969 H HB2  . LEU A 1 271 ? -14.44971 -3.59337  29.82014  1.000 59.54784  ? 271 LEU A HB2  1 
ATOM   3970 H HB3  . LEU A 1 271 ? -13.14480 -3.45377  28.92397  1.000 59.54784  ? 271 LEU A HB3  1 
ATOM   3971 H HG   . LEU A 1 271 ? -12.96099 -2.92035  31.65955  1.000 60.04579  ? 271 LEU A HG   1 
ATOM   3972 H HD11 . LEU A 1 271 ? -12.27310 -5.26684  31.85424  1.000 56.10974  ? 271 LEU A HD11 1 
ATOM   3973 H HD12 . LEU A 1 271 ? -13.83476 -4.97665  31.83189  1.000 56.10974  ? 271 LEU A HD12 1 
ATOM   3974 H HD13 . LEU A 1 271 ? -13.10202 -5.48270  30.51640  1.000 56.10974  ? 271 LEU A HD13 1 
ATOM   3975 H HD21 . LEU A 1 271 ? -10.76205 -3.36578  31.43231  1.000 62.59092  ? 271 LEU A HD21 1 
ATOM   3976 H HD22 . LEU A 1 271 ? -10.98018 -4.00297  29.99358  1.000 62.59092  ? 271 LEU A HD22 1 
ATOM   3977 H HD23 . LEU A 1 271 ? -11.14228 -2.43643  30.20136  1.000 62.59092  ? 271 LEU A HD23 1 
ATOM   3978 N N    . LEU A 1 272 ? -15.67643 -1.58844  27.83282  1.000 48.76797  ? 272 LEU A N    1 
ATOM   3979 C CA   . LEU A 1 272 ? -16.19183 -1.37848  26.48402  1.000 50.44015  ? 272 LEU A CA   1 
ATOM   3980 C C    . LEU A 1 272 ? -16.20726 0.10290   26.12699  1.000 53.25147  ? 272 LEU A C    1 
ATOM   3981 O O    . LEU A 1 272 ? -15.90672 0.47712   24.98687  1.000 49.84450  ? 272 LEU A O    1 
ATOM   3982 C CB   . LEU A 1 272 ? -17.59266 -1.97731  26.35827  1.000 47.35857  ? 272 LEU A CB   1 
ATOM   3983 C CG   . LEU A 1 272 ? -17.68045 -3.50468  26.38497  1.000 45.34594  ? 272 LEU A CG   1 
ATOM   3984 C CD1  . LEU A 1 272 ? -19.13013 -3.97530  26.35320  1.000 41.75832  ? 272 LEU A CD1  1 
ATOM   3985 C CD2  . LEU A 1 272 ? -16.89324 -4.10831  25.22351  1.000 43.00717  ? 272 LEU A CD2  1 
ATOM   3986 H H    . LEU A 1 272 ? -16.26309 -1.83781  28.41010  1.000 59.25763  ? 272 LEU A H    1 
ATOM   3987 H HA   . LEU A 1 272 ? -15.61411 -1.83492  25.85251  1.000 61.26425  ? 272 LEU A HA   1 
ATOM   3988 H HB2  . LEU A 1 272 ? -18.12904 -1.64693  27.09587  1.000 57.56635  ? 272 LEU A HB2  1 
ATOM   3989 H HB3  . LEU A 1 272 ? -17.97145 -1.68362  25.51497  1.000 57.56635  ? 272 LEU A HB3  1 
ATOM   3990 H HG   . LEU A 1 272 ? -17.28856 -3.82067  27.21410  1.000 55.15120  ? 272 LEU A HG   1 
ATOM   3991 H HD11 . LEU A 1 272 ? -19.14854 -4.94428  26.39379  1.000 50.84606  ? 272 LEU A HD11 1 
ATOM   3992 H HD12 . LEU A 1 272 ? -19.59972 -3.60329  27.11608  1.000 50.84606  ? 272 LEU A HD12 1 
ATOM   3993 H HD13 . LEU A 1 272 ? -19.54303 -3.67082  25.52997  1.000 50.84606  ? 272 LEU A HD13 1 
ATOM   3994 H HD21 . LEU A 1 272 ? -17.04106 -5.06683  25.20617  1.000 52.34468  ? 272 LEU A HD21 1 
ATOM   3995 H HD22 . LEU A 1 272 ? -17.20046 -3.71118  24.39357  1.000 52.34468  ? 272 LEU A HD22 1 
ATOM   3996 H HD23 . LEU A 1 272 ? -15.94992 -3.92134  25.35039  1.000 52.34468  ? 272 LEU A HD23 1 
ATOM   3997 N N    . GLN A 1 273 ? -16.53757 0.96060   27.09530  1.000 53.66931  ? 273 GLN A N    1 
ATOM   3998 C CA   . GLN A 1 273 ? -16.68605 2.38405   26.82221  1.000 56.83691  ? 273 GLN A CA   1 
ATOM   3999 C C    . GLN A 1 273 ? -15.35273 3.12043   26.80066  1.000 57.56430  ? 273 GLN A C    1 
ATOM   4000 O O    . GLN A 1 273 ? -15.20372 4.09333   26.05326  1.000 60.35971  ? 273 GLN A O    1 
ATOM   4001 C CB   . GLN A 1 273 ? -17.60208 3.02250   27.86959  1.000 56.45193  ? 273 GLN A CB   1 
ATOM   4002 C CG   . GLN A 1 273 ? -19.02984 2.51086   27.84782  1.000 55.32297  ? 273 GLN A CG   1 
ATOM   4003 C CD   . GLN A 1 273 ? -19.85621 3.05176   28.99718  1.000 57.13546  ? 273 GLN A CD   1 
ATOM   4004 O OE1  . GLN A 1 273 ? -19.31642 3.57164   29.97389  1.000 58.32241  ? 273 GLN A OE1  1 
ATOM   4005 N NE2  . GLN A 1 273 ? -21.17388 2.93221   28.88642  1.000 58.88550  ? 273 GLN A NE2  1 
ATOM   4006 H H    . GLN A 1 273 ? -16.67997 0.74153   27.91465  1.000 65.13924  ? 273 GLN A H    1 
ATOM   4007 H HA   . GLN A 1 273 ? -17.09446 2.48297   25.94796  1.000 68.94036  ? 273 GLN A HA   1 
ATOM   4008 H HB2  . GLN A 1 273 ? -17.23863 2.84089   28.75039  1.000 68.47839  ? 273 GLN A HB2  1 
ATOM   4009 H HB3  . GLN A 1 273 ? -17.63081 3.97941   27.71339  1.000 68.47839  ? 273 GLN A HB3  1 
ATOM   4010 H HG2  . GLN A 1 273 ? -19.45215 2.78413   27.01844  1.000 67.12363  ? 273 GLN A HG2  1 
ATOM   4011 H HG3  . GLN A 1 273 ? -19.02104 1.54306   27.91247  1.000 67.12363  ? 273 GLN A HG3  1 
ATOM   4012 H HE21 . GLN A 1 273 ? -21.51501 2.56312   28.18856  1.000 71.39866  ? 273 GLN A HE21 1 
ATOM   4013 H HE22 . GLN A 1 273 ? -21.68625 3.22387   29.51253  1.000 71.39866  ? 273 GLN A HE22 1 
ATOM   4014 N N    . ASN A 1 274 ? -14.38192 2.68552   27.60491  1.000 57.16420  ? 274 ASN A N    1 
ATOM   4015 C CA   . ASN A 1 274 ? -13.10842 3.37867   27.71660  1.000 58.39046  ? 274 ASN A CA   1 
ATOM   4016 C C    . ASN A 1 274 ? -11.91422 2.56266   27.24172  1.000 60.48376  ? 274 ASN A C    1 
ATOM   4017 O O    . ASN A 1 274 ? -10.82672 3.13071   27.08922  1.000 60.85804  ? 274 ASN A O    1 
ATOM   4018 C CB   . ASN A 1 274 ? -12.86800 3.80912   29.17381  1.000 61.71288  ? 274 ASN A CB   1 
ATOM   4019 C CG   . ASN A 1 274 ? -14.07050 4.51571   29.78045  1.000 64.36876  ? 274 ASN A CG   1 
ATOM   4020 O OD1  . ASN A 1 274 ? -14.62078 4.07524   30.78960  1.000 66.52900  ? 274 ASN A OD1  1 
ATOM   4021 N ND2  . ASN A 1 274 ? -14.48413 5.61622   29.16268  1.000 62.46413  ? 274 ASN A ND2  1 
ATOM   4022 H H    . ASN A 1 274 ? -14.44191 1.98410   28.09888  1.000 69.33311  ? 274 ASN A H    1 
ATOM   4023 H HA   . ASN A 1 274 ? -13.14626 4.17826   27.16877  1.000 70.80462  ? 274 ASN A HA   1 
ATOM   4024 H HB2  . ASN A 1 274 ? -12.67970 3.02264   29.70942  1.000 74.79153  ? 274 ASN A HB2  1 
ATOM   4025 H HB3  . ASN A 1 274 ? -12.11434 4.41905   29.20365  1.000 74.79153  ? 274 ASN A HB3  1 
ATOM   4026 H HD21 . ASN A 1 274 ? -15.16035 6.05180   29.46697  1.000 75.69302  ? 274 ASN A HD21 1 
ATOM   4027 H HD22 . ASN A 1 274 ? -14.07574 5.89326   28.45836  1.000 75.69302  ? 274 ASN A HD22 1 
ATOM   4028 N N    . GLY A 1 275 ? -12.07733 1.26572   26.99567  1.000 59.97634  ? 275 GLY A N    1 
ATOM   4029 C CA   . GLY A 1 275 ? -10.97150 0.43948   26.56358  1.000 61.81607  ? 275 GLY A CA   1 
ATOM   4030 C C    . GLY A 1 275 ? -10.10607 -0.02616  27.71991  1.000 63.40174  ? 275 GLY A C    1 
ATOM   4031 O O    . GLY A 1 275 ? -10.45498 0.09811   28.89726  1.000 62.79995  ? 275 GLY A O    1 
ATOM   4032 H H    . GLY A 1 275 ? -12.82327 0.84487   27.07355  1.000 72.70768  ? 275 GLY A H    1 
ATOM   4033 H HA2  . GLY A 1 275 ? -11.31614 -0.34334  26.10605  1.000 74.91535  ? 275 GLY A HA2  1 
ATOM   4034 H HA3  . GLY A 1 275 ? -10.41497 0.94432   25.95013  1.000 74.91535  ? 275 GLY A HA3  1 
ATOM   4035 N N    . MET A 1 276 ? -8.94389  -0.57703  27.36126  1.000 65.58816  ? 276 MET A N    1 
ATOM   4036 C CA   . MET A 1 276 ? -7.98075  -1.06844  28.33754  1.000 68.43227  ? 276 MET A CA   1 
ATOM   4037 C C    . MET A 1 276 ? -6.89469  -0.05489  28.67732  1.000 73.46630  ? 276 MET A C    1 
ATOM   4038 O O    . MET A 1 276 ? -6.13631  -0.28141  29.62624  1.000 69.71820  ? 276 MET A O    1 
ATOM   4039 C CB   . MET A 1 276 ? -7.31707  -2.35540  27.82751  1.000 65.19208  ? 276 MET A CB   1 
ATOM   4040 C CG   . MET A 1 276 ? -8.23775  -3.56320  27.78080  1.000 65.37913  ? 276 MET A CG   1 
ATOM   4041 S SD   . MET A 1 276 ? -7.32805  -5.09569  27.49247  1.000 54.03618  ? 276 MET A SD   1 
ATOM   4042 C CE   . MET A 1 276 ? -8.65313  -6.30027  27.55095  1.000 45.16443  ? 276 MET A CE   1 
ATOM   4043 H H    . MET A 1 276 ? -8.69053  -0.67693  26.54552  1.000 79.44185  ? 276 MET A H    1 
ATOM   4044 H HA   . MET A 1 276 ? -8.46357  -1.28466  29.15057  1.000 82.85479  ? 276 MET A HA   1 
ATOM   4045 H HB2  . MET A 1 276 ? -6.99235  -2.19952  26.92686  1.000 78.96656  ? 276 MET A HB2  1 
ATOM   4046 H HB3  . MET A 1 276 ? -6.57616  -2.57429  28.41406  1.000 78.96656  ? 276 MET A HB3  1 
ATOM   4047 H HG2  . MET A 1 276 ? -8.70384  -3.64201  28.62782  1.000 79.19103  ? 276 MET A HG2  1 
ATOM   4048 H HG3  . MET A 1 276 ? -8.87669  -3.44961  27.05986  1.000 79.19103  ? 276 MET A HG3  1 
ATOM   4049 H HE1  . MET A 1 276 ? -8.27843  -7.17250  27.75021  1.000 54.93338  ? 276 MET A HE1  1 
ATOM   4050 H HE2  . MET A 1 276 ? -9.28217  -6.04440  28.24358  1.000 54.93338  ? 276 MET A HE2  1 
ATOM   4051 H HE3  . MET A 1 276 ? -9.09944  -6.32083  26.68997  1.000 54.93338  ? 276 MET A HE3  1 
ATOM   4052 N N    . ASN A 1 277 ? -6.79737  1.04500   27.93146  1.000 75.73872  ? 277 ASN A N    1 
ATOM   4053 C CA   . ASN A 1 277 ? -5.80933  2.08953   28.20022  1.000 73.80566  ? 277 ASN A CA   1 
ATOM   4054 C C    . ASN A 1 277 ? -4.39337  1.51870   28.22757  1.000 72.80877  ? 277 ASN A C    1 
ATOM   4055 O O    . ASN A 1 277 ? -3.56932  1.88724   29.06775  1.000 83.31537  ? 277 ASN A O    1 
ATOM   4056 C CB   . ASN A 1 277 ? -6.12171  2.81764   29.50873  1.000 78.92465  ? 277 ASN A CB   1 
ATOM   4057 H H    . ASN A 1 277 ? -7.29987  1.21209   27.25383  1.000 91.62253  ? 277 ASN A H    1 
ATOM   4058 H HA   . ASN A 1 277 ? -5.84815  2.73669   27.47870  1.000 89.30286  ? 277 ASN A HA   1 
ATOM   4059 N N    . GLY A 1 278 ? -4.10911  0.60386   27.30224  1.000 69.42662  ? 278 GLY A N    1 
ATOM   4060 C CA   . GLY A 1 278 ? -2.78755  0.03908   27.16046  1.000 66.83160  ? 278 GLY A CA   1 
ATOM   4061 C C    . GLY A 1 278 ? -2.49153  -1.15491  28.03924  1.000 63.77605  ? 278 GLY A C    1 
ATOM   4062 O O    . GLY A 1 278 ? -1.44788  -1.79455  27.85372  1.000 61.11390  ? 278 GLY A O    1 
ATOM   4063 H H    . GLY A 1 278 ? -4.68070  0.29447   26.73907  1.000 84.04801  ? 278 GLY A H    1 
ATOM   4064 H HA2  . GLY A 1 278 ? -2.66878  -0.23895  26.23878  1.000 80.93399  ? 278 GLY A HA2  1 
ATOM   4065 H HA3  . GLY A 1 278 ? -2.13517  0.72574   27.36975  1.000 80.93399  ? 278 GLY A HA3  1 
ATOM   4066 N N    . ARG A 1 279 ? -3.36323  -1.47677  28.98824  1.000 63.33230  ? 279 ARG A N    1 
ATOM   4067 C CA   . ARG A 1 279 ? -3.12469  -2.61535  29.85838  1.000 58.26187  ? 279 ARG A CA   1 
ATOM   4068 C C    . ARG A 1 279 ? -3.51582  -3.91607  29.15801  1.000 54.05201  ? 279 ARG A C    1 
ATOM   4069 O O    . ARG A 1 279 ? -4.07563  -3.92346  28.05644  1.000 53.02610  ? 279 ARG A O    1 
ATOM   4070 C CB   . ARG A 1 279 ? -3.89793  -2.46090  31.16687  1.000 58.20692  ? 279 ARG A CB   1 
ATOM   4071 H H    . ARG A 1 279 ? -4.09487  -1.05307  29.14566  1.000 76.73482  ? 279 ARG A H    1 
ATOM   4072 H HA   . ARG A 1 279 ? -2.17929  -2.65885  30.07104  1.000 70.65031  ? 279 ARG A HA   1 
ATOM   4073 N N    . THR A 1 280 ? -3.20406  -5.03022  29.82118  1.000 50.32092  ? 280 THR A N    1 
ATOM   4074 C CA   . THR A 1 280 ? -3.55284  -6.35699  29.34016  1.000 46.62720  ? 280 THR A CA   1 
ATOM   4075 C C    . THR A 1 280 ? -4.31045  -7.10123  30.43162  1.000 45.26158  ? 280 THR A C    1 
ATOM   4076 O O    . THR A 1 280 ? -4.17484  -6.81200  31.62216  1.000 46.39325  ? 280 THR A O    1 
ATOM   4077 C CB   . THR A 1 280 ? -2.31101  -7.16593  28.94219  1.000 46.17478  ? 280 THR A CB   1 
ATOM   4078 O OG1  . THR A 1 280 ? -1.44493  -7.28860  30.07971  1.000 45.62258  ? 280 THR A OG1  1 
ATOM   4079 C CG2  . THR A 1 280 ? -1.56648  -6.48559  27.80317  1.000 44.59062  ? 280 THR A CG2  1 
ATOM   4080 H H    . THR A 1 280 ? -2.78046  -5.03836  30.56957  1.000 61.12117  ? 280 THR A H    1 
ATOM   4081 H HA   . THR A 1 280 ? -4.12373  -6.27250  28.56052  1.000 56.68871  ? 280 THR A HA   1 
ATOM   4082 H HB   . THR A 1 280 ? -2.57786  -8.04779  28.63885  1.000 56.14580  ? 280 THR A HB   1 
ATOM   4083 H HG1  . THR A 1 280 ? -1.38050  -8.09494  30.30612  1.000 55.48317  ? 280 THR A HG1  1 
ATOM   4084 H HG21 . THR A 1 280 ? -0.86903  -7.06989  27.46693  1.000 54.24481  ? 280 THR A HG21 1 
ATOM   4085 H HG22 . THR A 1 280 ? -2.18073  -6.28061  27.08097  1.000 54.24481  ? 280 THR A HG22 1 
ATOM   4086 H HG23 . THR A 1 280 ? -1.16261  -5.66119  28.11646  1.000 54.24481  ? 280 THR A HG23 1 
ATOM   4087 N N    . ILE A 1 281 ? -5.11044  -8.07514  30.00889  1.000 42.20800  ? 281 ILE A N    1 
ATOM   4088 C CA   . ILE A 1 281 ? -5.83357  -8.96375  30.91303  1.000 41.34262  ? 281 ILE A CA   1 
ATOM   4089 C C    . ILE A 1 281 ? -5.49278  -10.38968 30.50369  1.000 40.53481  ? 281 ILE A C    1 
ATOM   4090 O O    . ILE A 1 281 ? -5.76328  -10.79272 29.36669  1.000 39.62497  ? 281 ILE A O    1 
ATOM   4091 C CB   . ILE A 1 281 ? -7.35236  -8.72617  30.87022  1.000 39.73678  ? 281 ILE A CB   1 
ATOM   4092 C CG1  . ILE A 1 281 ? -7.66892  -7.26779  31.21609  1.000 42.78018  ? 281 ILE A CG1  1 
ATOM   4093 C CG2  . ILE A 1 281 ? -8.06059  -9.65932  31.83593  1.000 38.70637  ? 281 ILE A CG2  1 
ATOM   4094 C CD1  . ILE A 1 281 ? -9.15076  -6.93729  31.22423  1.000 42.60650  ? 281 ILE A CD1  1 
ATOM   4095 H H    . ILE A 1 281 ? -5.25448  -8.24564  29.17836  1.000 51.38567  ? 281 ILE A H    1 
ATOM   4096 H HA   . ILE A 1 281 ? -5.53811  -8.82062  31.82578  1.000 50.34721  ? 281 ILE A HA   1 
ATOM   4097 H HB   . ILE A 1 281 ? -7.66685  -8.91042  29.97131  1.000 48.42021  ? 281 ILE A HB   1 
ATOM   4098 H HG12 . ILE A 1 281 ? -7.31998  -7.07608  32.10062  1.000 52.07228  ? 281 ILE A HG12 1 
ATOM   4099 H HG13 . ILE A 1 281 ? -7.24323  -6.69404  30.55998  1.000 52.07228  ? 281 ILE A HG13 1 
ATOM   4100 H HG21 . ILE A 1 281 ? -9.01801  -9.52148  31.76345  1.000 47.18371  ? 281 ILE A HG21 1 
ATOM   4101 H HG22 . ILE A 1 281 ? -7.84021  -10.57608 31.60817  1.000 47.18371  ? 281 ILE A HG22 1 
ATOM   4102 H HG23 . ILE A 1 281 ? -7.76551  -9.46270  32.73880  1.000 47.18371  ? 281 ILE A HG23 1 
ATOM   4103 H HD11 . ILE A 1 281 ? -9.25931  -5.97341  31.23126  1.000 51.86387  ? 281 ILE A HD11 1 
ATOM   4104 H HD12 . ILE A 1 281 ? -9.56197  -7.31067  30.42900  1.000 51.86387  ? 281 ILE A HD12 1 
ATOM   4105 H HD13 . ILE A 1 281 ? -9.55567  -7.32155  32.01750  1.000 51.86387  ? 281 ILE A HD13 1 
ATOM   4106 N N    . LEU A 1 282 ? -4.88782  -11.14413 31.41737  1.000 39.53536  ? 282 LEU A N    1 
ATOM   4107 C CA   . LEU A 1 282 ? -4.40579  -12.49144 31.11688  1.000 40.83131  ? 282 LEU A CA   1 
ATOM   4108 C C    . LEU A 1 282 ? -3.55972  -12.49923 29.84565  1.000 40.99811  ? 282 LEU A C    1 
ATOM   4109 O O    . LEU A 1 282 ? -3.69247  -13.37376 28.98714  1.000 43.35803  ? 282 LEU A O    1 
ATOM   4110 C CB   . LEU A 1 282 ? -5.56625  -13.48000 30.99787  1.000 39.75295  ? 282 LEU A CB   1 
ATOM   4111 C CG   . LEU A 1 282 ? -6.28307  -13.85356 32.29344  1.000 36.56621  ? 282 LEU A CG   1 
ATOM   4112 C CD1  . LEU A 1 282 ? -7.47731  -14.74953 31.99142  1.000 35.89752  ? 282 LEU A CD1  1 
ATOM   4113 C CD2  . LEU A 1 282 ? -5.33952  -14.53650 33.26671  1.000 38.89814  ? 282 LEU A CD2  1 
ATOM   4114 H H    . LEU A 1 282 ? -4.74258  -10.89632 32.22798  1.000 48.17850  ? 282 LEU A H    1 
ATOM   4115 H HA   . LEU A 1 282 ? -3.84137  -12.78036 31.85094  1.000 49.73364  ? 282 LEU A HA   1 
ATOM   4116 H HB2  . LEU A 1 282 ? -6.23065  -13.09274 30.40668  1.000 48.43961  ? 282 LEU A HB2  1 
ATOM   4117 H HB3  . LEU A 1 282 ? -5.22162  -14.30245 30.61615  1.000 48.43961  ? 282 LEU A HB3  1 
ATOM   4118 H HG   . LEU A 1 282 ? -6.60286  -13.04225 32.71818  1.000 44.61551  ? 282 LEU A HG   1 
ATOM   4119 H HD11 . LEU A 1 282 ? -7.90507  -14.99755 32.82593  1.000 43.81309  ? 282 LEU A HD11 1 
ATOM   4120 H HD12 . LEU A 1 282 ? -8.10252  -14.26408 31.43074  1.000 43.81309  ? 282 LEU A HD12 1 
ATOM   4121 H HD13 . LEU A 1 282 ? -7.16714  -15.54423 31.52973  1.000 43.81309  ? 282 LEU A HD13 1 
ATOM   4122 H HD21 . LEU A 1 282 ? -5.85804  -14.92951 33.98614  1.000 47.41383  ? 282 LEU A HD21 1 
ATOM   4123 H HD22 . LEU A 1 282 ? -4.84788  -15.22836 32.79712  1.000 47.41383  ? 282 LEU A HD22 1 
ATOM   4124 H HD23 . LEU A 1 282 ? -4.72371  -13.87789 33.62436  1.000 47.41383  ? 282 LEU A HD23 1 
ATOM   4125 N N    . GLY A 1 283 ? -2.68487  -11.50477 29.71958  1.000 43.27726  ? 283 GLY A N    1 
ATOM   4126 C CA   . GLY A 1 283 ? -1.78462  -11.44730 28.58679  1.000 43.65447  ? 283 GLY A CA   1 
ATOM   4127 C C    . GLY A 1 283 ? -2.43564  -11.15350 27.25751  1.000 42.65645  ? 283 GLY A C    1 
ATOM   4128 O O    . GLY A 1 283 ? -1.86067  -11.47695 26.21356  1.000 45.21685  ? 283 GLY A O    1 
ATOM   4129 H H    . GLY A 1 283 ? -2.59695  -10.85584 30.27703  1.000 52.66878  ? 283 GLY A H    1 
ATOM   4130 H HA2  . GLY A 1 283 ? -1.12622  -10.75410 28.75071  1.000 53.12143  ? 283 GLY A HA2  1 
ATOM   4131 H HA3  . GLY A 1 283 ? -1.33135  -12.30137 28.50919  1.000 53.12143  ? 283 GLY A HA3  1 
ATOM   4132 N N    . SER A 1 284 ? -3.62043  -10.54942 27.26065  1.000 41.05647  ? 284 SER A N    1 
ATOM   4133 C CA   . SER A 1 284 ? -4.31813  -10.19165 26.03613  1.000 39.92439  ? 284 SER A CA   1 
ATOM   4134 C C    . SER A 1 284 ? -4.69250  -8.71988  26.07695  1.000 41.61656  ? 284 SER A C    1 
ATOM   4135 O O    . SER A 1 284 ? -5.03301  -8.18568  27.13684  1.000 41.27944  ? 284 SER A O    1 
ATOM   4136 C CB   . SER A 1 284 ? -5.57996  -11.03859 25.83971  1.000 41.03904  ? 284 SER A CB   1 
ATOM   4137 O OG   . SER A 1 284 ? -6.31898  -10.58790 24.71554  1.000 37.91636  ? 284 SER A OG   1 
ATOM   4138 H H    . SER A 1 284 ? -4.04647  -10.33339 27.97579  1.000 50.00383  ? 284 SER A H    1 
ATOM   4139 H HA   . SER A 1 284 ? -3.73140  -10.33970 25.27803  1.000 48.64533  ? 284 SER A HA   1 
ATOM   4140 H HB2  . SER A 1 284 ? -5.32137  -11.96269 25.69804  1.000 49.98292  ? 284 SER A HB2  1 
ATOM   4141 H HB3  . SER A 1 284 ? -6.13498  -10.96714 26.63202  1.000 49.98292  ? 284 SER A HB3  1 
ATOM   4142 H HG   . SER A 1 284 ? -6.96102  -10.10830 24.96729  1.000 46.23570  ? 284 SER A HG   1 
ATOM   4143 N N    . ALA A 1 285 ? -4.62944  -8.07229  24.91546  1.000 39.90232  ? 285 ALA A N    1 
ATOM   4144 C CA   . ALA A 1 285 ? -5.02031  -6.67913  24.76429  1.000 42.40399  ? 285 ALA A CA   1 
ATOM   4145 C C    . ALA A 1 285 ? -6.43564  -6.51990  24.22686  1.000 41.67125  ? 285 ALA A C    1 
ATOM   4146 O O    . ALA A 1 285 ? -6.86285  -5.39122  23.96709  1.000 43.35552  ? 285 ALA A O    1 
ATOM   4147 C CB   . ALA A 1 285 ? -4.03380  -5.95434  23.84105  1.000 43.07923  ? 285 ALA A CB   1 
ATOM   4148 H H    . ALA A 1 285 ? -4.35589  -8.43078  24.18317  1.000 48.61885  ? 285 ALA A H    1 
ATOM   4149 H HA   . ALA A 1 285 ? -4.98375  -6.25029  25.63358  1.000 51.62086  ? 285 ALA A HA   1 
ATOM   4150 H HB1  . ALA A 1 285 ? -4.37165  -5.06449  23.65416  1.000 52.43115  ? 285 ALA A HB1  1 
ATOM   4151 H HB2  . ALA A 1 285 ? -3.17257  -5.89503  24.28340  1.000 52.43115  ? 285 ALA A HB2  1 
ATOM   4152 H HB3  . ALA A 1 285 ? -3.94761  -6.45565  23.01512  1.000 52.43115  ? 285 ALA A HB3  1 
ATOM   4153 N N    . LEU A 1 286 ? -7.16238  -7.61728  24.04206  1.000 38.91478  ? 286 LEU A N    1 
ATOM   4154 C CA   . LEU A 1 286 ? -8.54777  -7.58942  23.59956  1.000 39.33285  ? 286 LEU A CA   1 
ATOM   4155 C C    . LEU A 1 286 ? -9.37952  -8.43622  24.55348  1.000 37.64342  ? 286 LEU A C    1 
ATOM   4156 O O    . LEU A 1 286 ? -8.85470  -9.26653  25.29963  1.000 36.46967  ? 286 LEU A O    1 
ATOM   4157 C CB   . LEU A 1 286 ? -8.68658  -8.10058  22.15899  1.000 40.56329  ? 286 LEU A CB   1 
ATOM   4158 C CG   . LEU A 1 286 ? -7.94106  -7.29521  21.09187  1.000 44.79497  ? 286 LEU A CG   1 
ATOM   4159 C CD1  . LEU A 1 286 ? -7.88266  -8.06097  19.77489  1.000 44.85615  ? 286 LEU A CD1  1 
ATOM   4160 C CD2  . LEU A 1 286 ? -8.58626  -5.92645  20.89032  1.000 45.10565  ? 286 LEU A CD2  1 
ATOM   4161 H H    . LEU A 1 286 ? -6.86390  -8.41345  24.17102  1.000 47.43381  ? 286 LEU A H    1 
ATOM   4162 H HA   . LEU A 1 286 ? -8.88961  -6.68190  23.62103  1.000 47.93549  ? 286 LEU A HA   1 
ATOM   4163 H HB2  . LEU A 1 286 ? -8.34605  -9.00822  22.12517  1.000 49.41202  ? 286 LEU A HB2  1 
ATOM   4164 H HB3  . LEU A 1 286 ? -9.62734  -8.09019  21.92288  1.000 49.41202  ? 286 LEU A HB3  1 
ATOM   4165 H HG   . LEU A 1 286 ? -7.03067  -7.15273  21.39486  1.000 54.49004  ? 286 LEU A HG   1 
ATOM   4166 H HD11 . LEU A 1 286 ? -7.44740  -7.50815  19.10718  1.000 54.56344  ? 286 LEU A HD11 1 
ATOM   4167 H HD12 . LEU A 1 286 ? -7.37813  -8.87879  19.90721  1.000 54.56344  ? 286 LEU A HD12 1 
ATOM   4168 H HD13 . LEU A 1 286 ? -8.78618  -8.27183  19.49186  1.000 54.56344  ? 286 LEU A HD13 1 
ATOM   4169 H HD21 . LEU A 1 286 ? -8.15601  -5.48139  20.14353  1.000 54.86285  ? 286 LEU A HD21 1 
ATOM   4170 H HD22 . LEU A 1 286 ? -9.53060  -6.04679  20.70418  1.000 54.86285  ? 286 LEU A HD22 1 
ATOM   4171 H HD23 . LEU A 1 286 ? -8.47260  -5.40171  21.69818  1.000 54.86285  ? 286 LEU A HD23 1 
ATOM   4172 N N    . LEU A 1 287 ? -10.68842 -8.21006  24.53156  1.000 34.84853  ? 287 LEU A N    1 
ATOM   4173 C CA   . LEU A 1 287 ? -11.60356 -8.93724  25.40353  1.000 35.59791  ? 287 LEU A CA   1 
ATOM   4174 C C    . LEU A 1 287 ? -11.90462 -10.30138 24.79218  1.000 33.19398  ? 287 LEU A C    1 
ATOM   4175 O O    . LEU A 1 287 ? -12.45037 -10.38448 23.68898  1.000 37.60610  ? 287 LEU A O    1 
ATOM   4176 C CB   . LEU A 1 287 ? -12.87974 -8.12798  25.61335  1.000 35.63214  ? 287 LEU A CB   1 
ATOM   4177 C CG   . LEU A 1 287 ? -12.68837 -6.79179  26.33616  1.000 34.98008  ? 287 LEU A CG   1 
ATOM   4178 C CD1  . LEU A 1 287 ? -13.97887 -5.98738  26.33804  1.000 36.84867  ? 287 LEU A CD1  1 
ATOM   4179 C CD2  . LEU A 1 287 ? -12.19400 -7.01401  27.76091  1.000 36.75075  ? 287 LEU A CD2  1 
ATOM   4180 H H    . LEU A 1 287 ? -11.07341 -7.63761  24.01806  1.000 42.55430  ? 287 LEU A H    1 
ATOM   4181 H HA   . LEU A 1 287 ? -11.19366 -9.07974  26.27104  1.000 43.45356  ? 287 LEU A HA   1 
ATOM   4182 H HB2  . LEU A 1 287 ? -13.26712 -7.93653  24.74491  1.000 43.49463  ? 287 LEU A HB2  1 
ATOM   4183 H HB3  . LEU A 1 287 ? -13.49582 -8.65931  26.14158  1.000 43.49463  ? 287 LEU A HB3  1 
ATOM   4184 H HG   . LEU A 1 287 ? -12.01652 -6.27716  25.86215  1.000 42.71217  ? 287 LEU A HG   1 
ATOM   4185 H HD11 . LEU A 1 287 ? -13.82696 -5.14774  26.79938  1.000 44.95447  ? 287 LEU A HD11 1 
ATOM   4186 H HD12 . LEU A 1 287 ? -14.24638 -5.81739  25.42128  1.000 44.95447  ? 287 LEU A HD12 1 
ATOM   4187 H HD13 . LEU A 1 287 ? -14.66727 -6.49584  26.79462  1.000 44.95447  ? 287 LEU A HD13 1 
ATOM   4188 H HD21 . LEU A 1 287 ? -12.15108 -6.15913  28.21723  1.000 44.83697  ? 287 LEU A HD21 1 
ATOM   4189 H HD22 . LEU A 1 287 ? -12.81142 -7.60393  28.22101  1.000 44.83697  ? 287 LEU A HD22 1 
ATOM   4190 H HD23 . LEU A 1 287 ? -11.31226 -7.41709  27.72997  1.000 44.83697  ? 287 LEU A HD23 1 
ATOM   4191 N N    . GLU A 1 288 ? -11.55338 -11.36633 25.50854  1.000 32.00657  ? 288 GLU A N    1 
ATOM   4192 C CA   . GLU A 1 288 ? -11.62103 -12.72731 24.98840  1.000 33.91506  ? 288 GLU A CA   1 
ATOM   4193 C C    . GLU A 1 288 ? -12.97822 -13.36017 25.26131  1.000 32.39108  ? 288 GLU A C    1 
ATOM   4194 O O    . GLU A 1 288 ? -13.50187 -13.26999 26.37233  1.000 31.77747  ? 288 GLU A O    1 
ATOM   4195 C CB   . GLU A 1 288 ? -10.51524 -13.57342 25.62469  1.000 35.03488  ? 288 GLU A CB   1 
ATOM   4196 C CG   . GLU A 1 288 ? -10.46099 -14.99876 25.13323  1.000 48.60931  ? 288 GLU A CG   1 
ATOM   4197 C CD   . GLU A 1 288 ? -10.08850 -15.08014 23.67328  1.000 51.77743  ? 288 GLU A CD   1 
ATOM   4198 O OE1  . GLU A 1 288 ? -9.23543  -14.27880 23.23510  1.000 46.12296  ? 288 GLU A OE1  1 
ATOM   4199 O OE2  . GLU A 1 288 ? -10.66110 -15.93076 22.96259  1.000 44.92881  ? 288 GLU A OE2  1 
ATOM   4200 H H    . GLU A 1 288 ? -11.26581 -11.32483 26.31798  1.000 39.14395  ? 288 GLU A H    1 
ATOM   4201 H HA   . GLU A 1 288 ? -11.50125 -12.70916 24.02599  1.000 41.43414  ? 288 GLU A HA   1 
ATOM   4202 H HB2  . GLU A 1 288 ? -9.65903  -13.16229 25.42777  1.000 42.77793  ? 288 GLU A HB2  1 
ATOM   4203 H HB3  . GLU A 1 288 ? -10.65828 -13.59890 26.58374  1.000 42.77793  ? 288 GLU A HB3  1 
ATOM   4204 H HG2  . GLU A 1 288 ? -9.79584  -15.48688 25.64334  1.000 59.06725  ? 288 GLU A HG2  1 
ATOM   4205 H HG3  . GLU A 1 288 ? -11.33275 -15.40867 25.24685  1.000 59.06725  ? 288 GLU A HG3  1 
ATOM   4206 N N    . ASP A 1 289 ? -13.54198 -14.02608 24.24408  1.000 32.02038  ? 289 ASP A N    1 
ATOM   4207 C CA   . ASP A 1 289 ? -14.89214 -14.56616 24.37495  1.000 31.34576  ? 289 ASP A CA   1 
ATOM   4208 C C    . ASP A 1 289 ? -15.00265 -16.02628 23.94716  1.000 32.18393  ? 289 ASP A C    1 
ATOM   4209 O O    . ASP A 1 289 ? -16.11393 -16.50683 23.69519  1.000 30.95591  ? 289 ASP A O    1 
ATOM   4210 C CB   . ASP A 1 289 ? -15.88718 -13.69767 23.58972  1.000 29.98604  ? 289 ASP A CB   1 
ATOM   4211 C CG   . ASP A 1 289 ? -15.91483 -14.00957 22.09938  1.000 30.87903  ? 289 ASP A CG   1 
ATOM   4212 O OD1  . ASP A 1 289 ? -14.94518 -14.59432 21.57102  1.000 31.68436  ? 289 ASP A OD1  1 
ATOM   4213 O OD2  . ASP A 1 289 ? -16.91902 -13.64804 21.44962  1.000 32.75934  ? 289 ASP A OD2  1 
ATOM   4214 H H    . ASP A 1 289 ? -13.16573 -14.17256 23.48475  1.000 39.16053  ? 289 ASP A H    1 
ATOM   4215 H HA   . ASP A 1 289 ? -15.13484 -14.54342 25.31382  1.000 38.35098  ? 289 ASP A HA   1 
ATOM   4216 H HB2  . ASP A 1 289 ? -16.77893 -13.84617 23.94131  1.000 36.71931  ? 289 ASP A HB2  1 
ATOM   4217 H HB3  . ASP A 1 289 ? -15.64044 -12.76539 23.69400  1.000 36.71931  ? 289 ASP A HB3  1 
ATOM   4218 N N    . GLU A 1 290 ? -13.88754 -16.75526 23.90300  1.000 33.24030  ? 290 GLU A N    1 
ATOM   4219 C CA   . GLU A 1 290 ? -13.90401 -18.17433 23.57778  1.000 34.20333  ? 290 GLU A CA   1 
ATOM   4220 C C    . GLU A 1 290 ? -13.73739 -19.06671 24.80357  1.000 33.61089  ? 290 GLU A C    1 
ATOM   4221 O O    . GLU A 1 290 ? -13.34619 -20.23109 24.66161  1.000 31.24861  ? 290 GLU A O    1 
ATOM   4222 C CB   . GLU A 1 290 ? -12.81681 -18.49909 22.55411  1.000 36.84363  ? 290 GLU A CB   1 
ATOM   4223 C CG   . GLU A 1 290 ? -13.12572 -18.01915 21.15816  1.000 38.84112  ? 290 GLU A CG   1 
ATOM   4224 C CD   . GLU A 1 290 ? -12.47147 -18.88220 20.09814  1.000 43.47324  ? 290 GLU A CD   1 
ATOM   4225 O OE1  . GLU A 1 290 ? -11.38154 -19.43418 20.36080  1.000 44.80941  ? 290 GLU A OE1  1 
ATOM   4226 O OE2  . GLU A 1 290 ? -13.05731 -19.01131 19.00634  1.000 41.60504  ? 290 GLU A OE2  1 
ATOM   4227 H H    . GLU A 1 290 ? -13.10173 -16.44313 24.06009  1.000 40.62443  ? 290 GLU A H    1 
ATOM   4228 H HA   . GLU A 1 290 ? -14.76627 -18.37426 23.18099  1.000 41.78007  ? 290 GLU A HA   1 
ATOM   4229 H HB2  . GLU A 1 290 ? -11.98958 -18.07746 22.83485  1.000 44.94842  ? 290 GLU A HB2  1 
ATOM   4230 H HB3  . GLU A 1 290 ? -12.70255 -19.46162 22.51675  1.000 44.94842  ? 290 GLU A HB3  1 
ATOM   4231 H HG2  . GLU A 1 290 ? -14.08526 -18.04381 21.01820  1.000 47.34541  ? 290 GLU A HG2  1 
ATOM   4232 H HG3  . GLU A 1 290 ? -12.79843 -17.11202 21.05379  1.000 47.34541  ? 290 GLU A HG3  1 
ATOM   4233 N N    . PHE A 1 291 ? -14.03033 -18.55253 25.99743  1.000 28.65511  ? 291 PHE A N    1 
ATOM   4234 C CA   . PHE A 1 291 ? -14.03421 -19.34864 27.21997  1.000 31.35328  ? 291 PHE A CA   1 
ATOM   4235 C C    . PHE A 1 291 ? -15.42766 -19.33293 27.83402  1.000 31.74394  ? 291 PHE A C    1 
ATOM   4236 O O    . PHE A 1 291 ? -15.91395 -18.27185 28.23771  1.000 29.45651  ? 291 PHE A O    1 
ATOM   4237 C CB   . PHE A 1 291 ? -13.03383 -18.81492 28.25029  1.000 34.72019  ? 291 PHE A CB   1 
ATOM   4238 C CG   . PHE A 1 291 ? -11.60200 -19.06010 27.90155  1.000 35.17180  ? 291 PHE A CG   1 
ATOM   4239 C CD1  . PHE A 1 291 ? -11.01166 -20.28604 28.15958  1.000 36.83664  ? 291 PHE A CD1  1 
ATOM   4240 C CD2  . PHE A 1 291 ? -10.83607 -18.05574 27.33689  1.000 34.84662  ? 291 PHE A CD2  1 
ATOM   4241 C CE1  . PHE A 1 291 ? -9.68900  -20.50986 27.84548  1.000 35.76348  ? 291 PHE A CE1  1 
ATOM   4242 C CE2  . PHE A 1 291 ? -9.51375  -18.27320 27.02409  1.000 37.44912  ? 291 PHE A CE2  1 
ATOM   4243 C CZ   . PHE A 1 291 ? -8.93890  -19.50077 27.27844  1.000 37.70041  ? 291 PHE A CZ   1 
ATOM   4244 H H    . PHE A 1 291 ? -14.23419 -17.72685 26.12510  1.000 35.12220  ? 291 PHE A H    1 
ATOM   4245 H HA   . PHE A 1 291 ? -13.79679 -20.25874 26.98283  1.000 38.36000  ? 291 PHE A HA   1 
ATOM   4246 H HB2  . PHE A 1 291 ? -13.15599 -17.85619 28.33283  1.000 42.40030  ? 291 PHE A HB2  1 
ATOM   4247 H HB3  . PHE A 1 291 ? -13.20664 -19.24593 29.10191  1.000 42.40030  ? 291 PHE A HB3  1 
ATOM   4248 H HD1  . PHE A 1 291 ? -11.51337 -20.96540 28.54900  1.000 44.94004  ? 291 PHE A HD1  1 
ATOM   4249 H HD2  . PHE A 1 291 ? -11.21874 -17.22531 27.16702  1.000 42.55201  ? 291 PHE A HD2  1 
ATOM   4250 H HE1  . PHE A 1 291 ? -9.30312  -21.33882 28.01527  1.000 43.65225  ? 291 PHE A HE1  1 
ATOM   4251 H HE2  . PHE A 1 291 ? -9.00811  -17.59288 26.64147  1.000 45.67502  ? 291 PHE A HE2  1 
ATOM   4252 H HZ   . PHE A 1 291 ? -8.04521  -19.64821 27.06755  1.000 45.97656  ? 291 PHE A HZ   1 
ATOM   4253 N N    . THR A 1 292 ? -16.04955 -20.50376 27.94405  1.000 32.15773  ? 292 THR A N    1 
ATOM   4254 C CA   . THR A 1 292 ? -17.33697 -20.59547 28.61450  1.000 30.66243  ? 292 THR A CA   1 
ATOM   4255 C C    . THR A 1 292 ? -17.16021 -20.59764 30.13086  1.000 32.04512  ? 292 THR A C    1 
ATOM   4256 O O    . THR A 1 292 ? -16.08195 -20.90971 30.64147  1.000 34.93291  ? 292 THR A O    1 
ATOM   4257 C CB   . THR A 1 292 ? -18.07648 -21.86860 28.21190  1.000 31.35205  ? 292 THR A CB   1 
ATOM   4258 O OG1  . THR A 1 292 ? -17.33048 -23.00546 28.66071  1.000 33.54503  ? 292 THR A OG1  1 
ATOM   4259 C CG2  . THR A 1 292 ? -18.26203 -21.94013 26.71115  1.000 30.65514  ? 292 THR A CG2  1 
ATOM   4260 H H    . THR A 1 292 ? -15.74799 -21.25007 27.64126  1.000 39.32534  ? 292 THR A H    1 
ATOM   4261 H HA   . THR A 1 292 ? -17.87139 -19.83000 28.35113  1.000 37.53098  ? 292 THR A HA   1 
ATOM   4262 H HB   . THR A 1 292 ? -18.95791 -21.87379 28.61680  1.000 38.35853  ? 292 THR A HB   1 
ATOM   4263 H HG1  . THR A 1 292 ? -17.84706 -23.65495 28.79077  1.000 40.99011  ? 292 THR A HG1  1 
ATOM   4264 H HG21 . THR A 1 292 ? -18.88258 -22.65121 26.48710  1.000 37.52223  ? 292 THR A HG21 1 
ATOM   4265 H HG22 . THR A 1 292 ? -18.61407 -21.09914 26.37993  1.000 37.52223  ? 292 THR A HG22 1 
ATOM   4266 H HG23 . THR A 1 292 ? -17.41145 -22.11707 26.27975  1.000 37.52223  ? 292 THR A HG23 1 
ATOM   4267 N N    . PRO A 1 293 ? -18.21537 -20.27348 30.88096  1.000 33.14155  ? 293 PRO A N    1 
ATOM   4268 C CA   . PRO A 1 293 ? -18.13412 -20.43625 32.34420  1.000 34.17818  ? 293 PRO A CA   1 
ATOM   4269 C C    . PRO A 1 293 ? -17.66874 -21.82200 32.76182  1.000 39.13861  ? 293 PRO A C    1 
ATOM   4270 O O    . PRO A 1 293 ? -16.95562 -21.95073 33.76423  1.000 38.37670  ? 293 PRO A O    1 
ATOM   4271 C CB   . PRO A 1 293 ? -19.56783 -20.13771 32.80601  1.000 35.50328  ? 293 PRO A CB   1 
ATOM   4272 C CG   . PRO A 1 293 ? -20.08609 -19.16843 31.77324  1.000 34.68078  ? 293 PRO A CG   1 
ATOM   4273 C CD   . PRO A 1 293 ? -19.48248 -19.64224 30.46016  1.000 31.84353  ? 293 PRO A CD   1 
ATOM   4274 H HA   . PRO A 1 293 ? -17.54071 -19.77202 32.72833  1.000 41.74988  ? 293 PRO A HA   1 
ATOM   4275 H HB2  . PRO A 1 293 ? -20.09267 -20.95339 32.81674  1.000 43.34001  ? 293 PRO A HB2  1 
ATOM   4276 H HB3  . PRO A 1 293 ? -19.55836 -19.73765 33.68961  1.000 43.34001  ? 293 PRO A HB3  1 
ATOM   4277 H HG2  . PRO A 1 293 ? -21.05500 -19.20287 31.74284  1.000 42.35300  ? 293 PRO A HG2  1 
ATOM   4278 H HG3  . PRO A 1 293 ? -19.79261 -18.26872 31.98606  1.000 42.35300  ? 293 PRO A HG3  1 
ATOM   4279 H HD2  . PRO A 1 293 ? -20.06246 -20.28711 30.02580  1.000 38.94831  ? 293 PRO A HD2  1 
ATOM   4280 H HD3  . PRO A 1 293 ? -19.31533 -18.89362 29.86642  1.000 38.94831  ? 293 PRO A HD3  1 
ATOM   4281 N N    . PHE A 1 294 ? -18.02095 -22.86551 32.00772  1.000 38.42909  ? 294 PHE A N    1 
ATOM   4282 C CA   . PHE A 1 294 ? -17.56484 -24.20518 32.36729  1.000 45.26769  ? 294 PHE A CA   1 
ATOM   4283 C C    . PHE A 1 294 ? -16.09169 -24.39551 32.01866  1.000 43.94677  ? 294 PHE A C    1 
ATOM   4284 O O    . PHE A 1 294 ? -15.35296 -25.05527 32.76000  1.000 48.28112  ? 294 PHE A O    1 
ATOM   4285 C CB   . PHE A 1 294 ? -18.42613 -25.26473 31.68377  1.000 51.89724  ? 294 PHE A CB   1 
ATOM   4286 C CG   . PHE A 1 294 ? -18.15583 -26.66029 32.16977  1.000 64.54934  ? 294 PHE A CG   1 
ATOM   4287 C CD1  . PHE A 1 294 ? -18.22765 -26.96201 33.52042  1.000 78.24599  ? 294 PHE A CD1  1 
ATOM   4288 C CD2  . PHE A 1 294 ? -17.83024 -27.66905 31.27984  1.000 66.20938  ? 294 PHE A CD2  1 
ATOM   4289 C CE1  . PHE A 1 294 ? -17.97571 -28.24113 33.97394  1.000 92.28888  ? 294 PHE A CE1  1 
ATOM   4290 C CE2  . PHE A 1 294 ? -17.58032 -28.95262 31.72757  1.000 71.92484  ? 294 PHE A CE2  1 
ATOM   4291 C CZ   . PHE A 1 294 ? -17.65337 -29.23777 33.07655  1.000 78.06386  ? 294 PHE A CZ   1 
ATOM   4292 H H    . PHE A 1 294 ? -18.51032 -22.82474 31.30171  1.000 46.85097  ? 294 PHE A H    1 
ATOM   4293 H HA   . PHE A 1 294 ? -17.66572 -24.32125 33.32503  1.000 55.05730  ? 294 PHE A HA   1 
ATOM   4294 H HB2  . PHE A 1 294 ? -19.36023 -25.06635 31.85407  1.000 63.01276  ? 294 PHE A HB2  1 
ATOM   4295 H HB3  . PHE A 1 294 ? -18.25089 -25.24295 30.72998  1.000 63.01276  ? 294 PHE A HB3  1 
ATOM   4296 H HD1  . PHE A 1 294 ? -18.44838 -26.29426 34.12895  1.000 94.63126  ? 294 PHE A HD1  1 
ATOM   4297 H HD2  . PHE A 1 294 ? -17.77905 -27.48114 30.37046  1.000 80.18732  ? 294 PHE A HD2  1 
ATOM   4298 H HE1  . PHE A 1 294 ? -18.02323 -28.43067 34.88318  1.000 111.48272 ? 294 PHE A HE1  1 
ATOM   4299 H HE2  . PHE A 1 294 ? -17.36323 -29.62331 31.12099  1.000 87.04587  ? 294 PHE A HE2  1 
ATOM   4300 H HZ   . PHE A 1 294 ? -17.48544 -30.10078 33.37974  1.000 94.41270  ? 294 PHE A HZ   1 
ATOM   4301 N N    . ASP A 1 295 ? -15.64074 -23.83079 30.89338  1.000 39.50180  ? 295 ASP A N    1 
ATOM   4302 C CA   . ASP A 1 295 ? -14.21905 -23.90133 30.56543  1.000 39.99927  ? 295 ASP A CA   1 
ATOM   4303 C C    . ASP A 1 295 ? -13.37076 -23.29361 31.67587  1.000 42.34315  ? 295 ASP A C    1 
ATOM   4304 O O    . ASP A 1 295 ? -12.29441 -23.80820 32.00422  1.000 41.81000  ? 295 ASP A O    1 
ATOM   4305 C CB   . ASP A 1 295 ? -13.93098 -23.18287 29.24842  1.000 36.91416  ? 295 ASP A CB   1 
ATOM   4306 C CG   . ASP A 1 295 ? -14.63720 -23.81006 28.07680  1.000 35.63775  ? 295 ASP A CG   1 
ATOM   4307 O OD1  . ASP A 1 295 ? -15.02541 -24.99228 28.17039  1.000 38.06457  ? 295 ASP A OD1  1 
ATOM   4308 O OD2  . ASP A 1 295 ? -14.80135 -23.11145 27.05556  1.000 32.37813  ? 295 ASP A OD2  1 
ATOM   4309 H H    . ASP A 1 295 ? -16.12593 -23.41252 30.31958  1.000 48.13823  ? 295 ASP A H    1 
ATOM   4310 H HA   . ASP A 1 295 ? -13.97987 -24.83534 30.45901  1.000 48.73519  ? 295 ASP A HA   1 
ATOM   4311 H HB2  . ASP A 1 295 ? -14.22724 -22.26194 29.31932  1.000 45.03306  ? 295 ASP A HB2  1 
ATOM   4312 H HB3  . ASP A 1 295 ? -12.97716 -23.21206 29.07443  1.000 45.03306  ? 295 ASP A HB3  1 
ATOM   4313 N N    . VAL A 1 296 ? -13.83160 -22.18363 32.25290  1.000 41.61028  ? 296 VAL A N    1 
ATOM   4314 C CA   . VAL A 1 296 ? -13.07166 -21.52945 33.31213  1.000 39.72760  ? 296 VAL A CA   1 
ATOM   4315 C C    . VAL A 1 296 ? -13.06010 -22.39623 34.56516  1.000 42.79297  ? 296 VAL A C    1 
ATOM   4316 O O    . VAL A 1 296 ? -12.00728 -22.61715 35.17393  1.000 44.61350  ? 296 VAL A O    1 
ATOM   4317 C CB   . VAL A 1 296 ? -13.64156 -20.12679 33.58950  1.000 37.86862  ? 296 VAL A CB   1 
ATOM   4318 C CG1  . VAL A 1 296 ? -12.90448 -19.46420 34.74024  1.000 39.85019  ? 296 VAL A CG1  1 
ATOM   4319 C CG2  . VAL A 1 296 ? -13.55423 -19.26751 32.33004  1.000 36.54465  ? 296 VAL A CG2  1 
ATOM   4320 H H    . VAL A 1 296 ? -14.57190 -21.79523 32.05114  1.000 50.66840  ? 296 VAL A H    1 
ATOM   4321 H HA   . VAL A 1 296 ? -12.15344 -21.42254 33.01832  1.000 48.40919  ? 296 VAL A HA   1 
ATOM   4322 H HB   . VAL A 1 296 ? -14.57425 -20.20978 33.84266  1.000 46.17842  ? 296 VAL A HB   1 
ATOM   4323 H HG11 . VAL A 1 296 ? -13.16808 -18.53198 34.78910  1.000 48.55629  ? 296 VAL A HG11 1 
ATOM   4324 H HG12 . VAL A 1 296 ? -13.13603 -19.91715 35.56615  1.000 48.55629  ? 296 VAL A HG12 1 
ATOM   4325 H HG13 . VAL A 1 296 ? -11.94953 -19.53013 34.58332  1.000 48.55629  ? 296 VAL A HG13 1 
ATOM   4326 H HG21 . VAL A 1 296 ? -13.93781 -18.39601 32.51511  1.000 44.58965  ? 296 VAL A HG21 1 
ATOM   4327 H HG22 . VAL A 1 296 ? -12.62274 -19.17194 32.07690  1.000 44.58965  ? 296 VAL A HG22 1 
ATOM   4328 H HG23 . VAL A 1 296 ? -14.04799 -19.70152 31.61677  1.000 44.58965  ? 296 VAL A HG23 1 
ATOM   4329 N N    . VAL A 1 297 ? -14.22491 -22.91552 34.95986  1.000 44.44342  ? 297 VAL A N    1 
ATOM   4330 C CA   . VAL A 1 297 ? -14.28019 -23.80811 36.11570  1.000 47.82334  ? 297 VAL A CA   1 
ATOM   4331 C C    . VAL A 1 297 ? -13.37850 -25.01676 35.89358  1.000 51.81768  ? 297 VAL A C    1 
ATOM   4332 O O    . VAL A 1 297 ? -12.58202 -25.38856 36.76475  1.000 53.47669  ? 297 VAL A O    1 
ATOM   4333 C CB   . VAL A 1 297 ? -15.72982 -24.24108 36.39830  1.000 47.35147  ? 297 VAL A CB   1 
ATOM   4334 C CG1  . VAL A 1 297 ? -15.75083 -25.42001 37.36610  1.000 48.55863  ? 297 VAL A CG1  1 
ATOM   4335 C CG2  . VAL A 1 297 ? -16.53757 -23.08371 36.95571  1.000 46.94364  ? 297 VAL A CG2  1 
ATOM   4336 H H    . VAL A 1 297 ? -14.98335 -22.76895 34.58185  1.000 54.06817  ? 297 VAL A H    1 
ATOM   4337 H HA   . VAL A 1 297 ? -13.95467 -23.32315 36.89013  1.000 58.12408  ? 297 VAL A HA   1 
ATOM   4338 H HB   . VAL A 1 297 ? -16.14025 -24.51974 35.56475  1.000 57.55784  ? 297 VAL A HB   1 
ATOM   4339 H HG11 . VAL A 1 297 ? -16.63803 -25.49720 37.75056  1.000 59.00642  ? 297 VAL A HG11 1 
ATOM   4340 H HG12 . VAL A 1 297 ? -15.52867 -26.23039 36.88151  1.000 59.00642  ? 297 VAL A HG12 1 
ATOM   4341 H HG13 . VAL A 1 297 ? -15.09884 -25.26463 38.06729  1.000 59.00642  ? 297 VAL A HG13 1 
ATOM   4342 H HG21 . VAL A 1 297 ? -17.41863 -23.40434 37.20437  1.000 57.06843  ? 297 VAL A HG21 1 
ATOM   4343 H HG22 . VAL A 1 297 ? -16.08295 -22.72776 37.73514  1.000 57.06843  ? 297 VAL A HG22 1 
ATOM   4344 H HG23 . VAL A 1 297 ? -16.61544 -22.39646 36.27562  1.000 57.06843  ? 297 VAL A HG23 1 
ATOM   4345 N N    . ARG A 1 298 ? -13.50032 -25.65523 34.72500  1.000 49.83251  ? 298 ARG A N    1 
ATOM   4346 C CA   . ARG A 1 298 ? -12.68764 -26.83188 34.43293  1.000 53.71607  ? 298 ARG A CA   1 
ATOM   4347 C C    . ARG A 1 298 ? -11.20788 -26.54460 34.65926  1.000 54.39283  ? 298 ARG A C    1 
ATOM   4348 O O    . ARG A 1 298 ? -10.52819 -27.25725 35.40671  1.000 58.73817  ? 298 ARG A O    1 
ATOM   4349 C CB   . ARG A 1 298 ? -12.92072 -27.29902 32.99137  1.000 53.30042  ? 298 ARG A CB   1 
ATOM   4350 C CG   . ARG A 1 298 ? -14.15546 -28.16672 32.79450  1.000 60.60642  ? 298 ARG A CG   1 
ATOM   4351 C CD   . ARG A 1 298 ? -14.09157 -28.99312 31.50091  1.000 75.77030  ? 298 ARG A CD   1 
ATOM   4352 N NE   . ARG A 1 298 ? -14.13330 -28.18263 30.28855  1.000 68.30495  ? 298 ARG A NE   1 
ATOM   4353 C CZ   . ARG A 1 298 ? -13.10226 -27.98614 29.47611  1.000 53.82881  ? 298 ARG A CZ   1 
ATOM   4354 N NH1  . ARG A 1 298 ? -11.91736 -28.52284 29.71838  1.000 52.48674  ? 298 ARG A NH1  1 
ATOM   4355 N NH2  . ARG A 1 298 ? -13.26739 -27.23769 28.38904  1.000 45.08616  ? 298 ARG A NH2  1 
ATOM   4356 H H    . ARG A 1 298 ? -14.03966 -25.42821 34.09478  1.000 60.53508  ? 298 ARG A H    1 
ATOM   4357 H HA   . ARG A 1 298 ? -12.95947 -27.54748 35.02869  1.000 65.19536  ? 298 ARG A HA   1 
ATOM   4358 H HB2  . ARG A 1 298 ? -13.02060 -26.51678 32.42653  1.000 64.69657  ? 298 ARG A HB2  1 
ATOM   4359 H HB3  . ARG A 1 298 ? -12.15149 -27.81723 32.70742  1.000 64.69657  ? 298 ARG A HB3  1 
ATOM   4360 H HG2  . ARG A 1 298 ? -14.23395 -28.78152 33.54067  1.000 73.46378  ? 298 ARG A HG2  1 
ATOM   4361 H HG3  . ARG A 1 298 ? -14.93974 -27.59771 32.74956  1.000 73.46378  ? 298 ARG A HG3  1 
ATOM   4362 H HD2  . ARG A 1 298 ? -13.26294 -29.49729 31.49194  1.000 91.66043  ? 298 ARG A HD2  1 
ATOM   4363 H HD3  . ARG A 1 298 ? -14.84879 -29.59895 31.47857  1.000 91.66043  ? 298 ARG A HD3  1 
ATOM   4364 H HE   . ARG A 1 298 ? -14.87906 -27.80531 30.08586  1.000 82.70200  ? 298 ARG A HE   1 
ATOM   4365 H HH11 . ARG A 1 298 ? -11.80151 -29.01229 30.41596  1.000 63.72016  ? 298 ARG A HH11 1 
ATOM   4366 H HH12 . ARG A 1 298 ? -11.26306 -28.38222 29.17826  1.000 63.72016  ? 298 ARG A HH12 1 
ATOM   4367 H HH21 . ARG A 1 298 ? -14.03481 -26.88822 28.22008  1.000 54.83946  ? 298 ARG A HH21 1 
ATOM   4368 H HH22 . ARG A 1 298 ? -12.60674 -27.10324 27.85512  1.000 54.83946  ? 298 ARG A HH22 1 
ATOM   4369 N N    . GLN A 1 299 ? -10.69444 -25.48739 34.02593  1.000 49.34552  ? 299 GLN A N    1 
ATOM   4370 C CA   . GLN A 1 299 ? -9.26215  -25.22351 34.07763  1.000 51.25866  ? 299 GLN A CA   1 
ATOM   4371 C C    . GLN A 1 299 ? -8.83024  -24.68892 35.43734  1.000 54.47858  ? 299 GLN A C    1 
ATOM   4372 O O    . GLN A 1 299 ? -7.67144  -24.86646 35.82759  1.000 57.09631  ? 299 GLN A O    1 
ATOM   4373 C CB   . GLN A 1 299 ? -8.86878  -24.24014 32.97188  1.000 47.40723  ? 299 GLN A CB   1 
ATOM   4374 C CG   . GLN A 1 299 ? -7.37089  -23.98087 32.89362  1.000 43.86149  ? 299 GLN A CG   1 
ATOM   4375 C CD   . GLN A 1 299 ? -6.96327  -23.09675 31.72298  1.000 41.66323  ? 299 GLN A CD   1 
ATOM   4376 O OE1  . GLN A 1 299 ? -5.93754  -22.42246 31.77927  1.000 37.32937  ? 299 GLN A OE1  1 
ATOM   4377 N NE2  . GLN A 1 299 ? -7.75364  -23.11272 30.65387  1.000 39.76945  ? 299 GLN A NE2  1 
ATOM   4378 H H    . GLN A 1 299 ? -11.14836 -24.91855 33.56770  1.000 59.95070  ? 299 GLN A H    1 
ATOM   4379 H HA   . GLN A 1 299 ? -8.78997  -26.05663 33.92321  1.000 62.24646  ? 299 GLN A HA   1 
ATOM   4380 H HB2  . GLN A 1 299 ? -9.15294  -24.60056 32.11734  1.000 57.62474  ? 299 GLN A HB2  1 
ATOM   4381 H HB3  . GLN A 1 299 ? -9.30891  -23.39165 33.13696  1.000 57.62474  ? 299 GLN A HB3  1 
ATOM   4382 H HG2  . GLN A 1 299 ? -7.08691  -23.54057 33.70995  1.000 53.36985  ? 299 GLN A HG2  1 
ATOM   4383 H HG3  . GLN A 1 299 ? -6.91144  -24.82972 32.79742  1.000 53.36985  ? 299 GLN A HG3  1 
ATOM   4384 H HE21 . GLN A 1 299 ? -8.45718  -23.60728 30.64658  1.000 48.45941  ? 299 GLN A HE21 1 
ATOM   4385 H HE22 . GLN A 1 299 ? -7.56131  -22.62850 29.96966  1.000 48.45941  ? 299 GLN A HE22 1 
ATOM   4386 N N    . CYS A 1 300 ? -9.72741  -24.03869 36.16899  1.000 56.36609  ? 300 CYS A N    1 
ATOM   4387 C CA   . CYS A 1 300 ? -9.38985  -23.47274 37.46837  1.000 58.11322  ? 300 CYS A CA   1 
ATOM   4388 C C    . CYS A 1 300 ? -9.56791  -24.46013 38.61444  1.000 61.48318  ? 300 CYS A C    1 
ATOM   4389 O O    . CYS A 1 300 ? -9.22219  -24.12786 39.75413  1.000 62.24438  ? 300 CYS A O    1 
ATOM   4390 C CB   . CYS A 1 300 ? -10.22843 -22.21990 37.73438  1.000 54.05469  ? 300 CYS A CB   1 
ATOM   4391 S SG   . CYS A 1 300 ? -9.63783  -20.74253 36.87539  1.000 55.89615  ? 300 CYS A SG   1 
ATOM   4392 H H    . CYS A 1 300 ? -10.54434 -23.91143 35.93227  1.000 68.37537  ? 300 CYS A H    1 
ATOM   4393 H HA   . CYS A 1 300 ? -8.45715  -23.20686 37.45204  1.000 70.47193  ? 300 CYS A HA   1 
ATOM   4394 H HB2  . CYS A 1 300 ? -11.13814 -22.38720 37.44227  1.000 65.60170  ? 300 CYS A HB2  1 
ATOM   4395 H HB3  . CYS A 1 300 ? -10.21463 -22.03316 38.68613  1.000 65.60170  ? 300 CYS A HB3  1 
ATOM   4396 H HG   . CYS A 1 300 ? -9.57214  -20.97417 35.69980  1.000 67.81144  ? 300 CYS A HG   1 
ATOM   4397 N N    . SER A 1 301 ? -10.09071 -25.66277 38.34473  1.000 62.53009  ? 301 SER A N    1 
ATOM   4398 C CA   . SER A 1 301 ? -10.24354 -26.68452 39.37107  1.000 66.81132  ? 301 SER A CA   1 
ATOM   4399 C C    . SER A 1 301 ? -9.60297  -28.01647 39.00068  1.000 76.26476  ? 301 SER A C    1 
ATOM   4400 O O    . SER A 1 301 ? -9.70575  -28.97058 39.78167  1.000 74.13304  ? 301 SER A O    1 
ATOM   4401 C CB   . SER A 1 301 ? -11.73175 -26.91538 39.68349  1.000 65.67994  ? 301 SER A CB   1 
ATOM   4402 O OG   . SER A 1 301 ? -12.30665 -27.85846 38.79608  1.000 66.53294  ? 301 SER A OG   1 
ATOM   4403 H H    . SER A 1 301 ? -10.36463 -25.90695 37.56694  1.000 75.77218  ? 301 SER A H    1 
ATOM   4404 H HA   . SER A 1 301 ? -9.81636  -26.36665 40.18186  1.000 80.90966  ? 301 SER A HA   1 
ATOM   4405 H HB2  . SER A 1 301 ? -11.81354 -27.24844 40.59084  1.000 79.55200  ? 301 SER A HB2  1 
ATOM   4406 H HB3  . SER A 1 301 ? -12.20483 -26.07317 39.59533  1.000 79.55200  ? 301 SER A HB3  1 
ATOM   4407 H HG   . SER A 1 301 ? -12.09456 -28.63749 39.02788  1.000 80.57559  ? 301 SER A HG   1 
ATOM   4408 N N    . GLY A 1 302 ? -8.96426  -28.11601 37.83677  1.000 75.02733  ? 302 GLY A N    1 
ATOM   4409 C CA   . GLY A 1 302 ? -8.24193  -29.31687 37.46313  1.000 73.63361  ? 302 GLY A CA   1 
ATOM   4410 C C    . GLY A 1 302 ? -9.11175  -30.53599 37.22067  1.000 73.29136  ? 302 GLY A C    1 
ATOM   4411 O O    . GLY A 1 302 ? -8.86329  -31.60485 37.78990  1.000 73.51817  ? 302 GLY A O    1 
ATOM   4412 H H    . GLY A 1 302 ? -8.93687  -27.49354 37.24399  1.000 90.76887  ? 302 GLY A H    1 
ATOM   4413 H HA2  . GLY A 1 302 ? -7.74665  -29.14091 36.64788  1.000 89.09640  ? 302 GLY A HA2  1 
ATOM   4414 H HA3  . GLY A 1 302 ? -7.61660  -29.53669 38.17133  1.000 89.09640  ? 302 GLY A HA3  1 
ATOM   4415 N N    . VAL A 1 303 ? -10.12992 -30.39741 36.36845  1.000 72.14520  ? 303 VAL A N    1 
ATOM   4416 C CA   . VAL A 1 303 ? -10.99187 -31.52480 36.04214  1.000 71.42648  ? 303 VAL A CA   1 
ATOM   4417 C C    . VAL A 1 303 ? -10.21107 -32.53930 35.21750  1.000 70.02723  ? 303 VAL A C    1 
ATOM   4418 O O    . VAL A 1 303 ? -9.45851  -32.17762 34.29883  1.000 65.01048  ? 303 VAL A O    1 
ATOM   4419 C CB   . VAL A 1 303 ? -12.24354 -31.04007 35.29041  1.000 70.37967  ? 303 VAL A CB   1 
ATOM   4420 H H    . VAL A 1 303 ? -10.33842 -29.66426 35.97019  1.000 87.31031  ? 303 VAL A H    1 
ATOM   4421 H HA   . VAL A 1 303 ? -11.27994 -31.95378 36.86305  1.000 86.44785  ? 303 VAL A HA   1 
ATOM   4422 N N    . THR A 1 304 ? -10.40105 -33.81966 35.53238  1.000 70.03611  ? 304 THR A N    1 
ATOM   4423 C CA   . THR A 1 304 ? -9.66942  -34.88874 34.86532  1.000 65.43069  ? 304 THR A CA   1 
ATOM   4424 C C    . THR A 1 304 ? -10.54414 -35.67231 33.88429  1.000 64.06036  ? 304 THR A C    1 
ATOM   4425 O O    . THR A 1 304 ? -11.76941 -35.60492 33.93664  1.000 63.44782  ? 304 THR A O    1 
ATOM   4426 C CB   . THR A 1 304 ? -9.07277  -35.88264 35.88741  1.000 63.51544  ? 304 THR A CB   1 
ATOM   4427 H H    . THR A 1 304 ? -10.95196 -34.09450 36.13285  1.000 84.77941  ? 304 THR A H    1 
ATOM   4428 H HA   . THR A 1 304 ? -8.95021  -34.48490 34.35487  1.000 79.25290  ? 304 THR A HA   1 
HETATM 4429 O O    . HOH B 2 .   ? -16.40939 -12.91685 13.67552  1.000 45.82945  ? 401 HOH A O    1 
HETATM 4430 O O    . HOH B 2 .   ? -24.89529 -16.72162 10.19835  1.000 35.15234  ? 402 HOH A O    1 
HETATM 4431 O O    . HOH B 2 .   ? -2.21668  -41.49288 18.59699  1.000 39.18452  ? 403 HOH A O    1 
HETATM 4432 O O    . HOH B 2 .   ? -9.92053  -43.93263 20.05475  1.000 39.27622  ? 404 HOH A O    1 
HETATM 4433 O O    . HOH B 2 .   ? -15.19204 -1.15133  23.24721  1.000 53.16564  ? 405 HOH A O    1 
HETATM 4434 O O    . HOH B 2 .   ? -14.34974 -20.17280 16.77189  1.000 33.85366  ? 406 HOH A O    1 
HETATM 4435 O O    . HOH B 2 .   ? -25.06511 -39.43716 11.39441  1.000 37.02371  ? 407 HOH A O    1 
HETATM 4436 O O    . HOH B 2 .   ? -10.67654 -34.75874 13.67857  1.000 30.84731  ? 408 HOH A O    1 
HETATM 4437 O O    . HOH B 2 .   ? -29.41439 -21.16097 3.69147   1.000 46.15598  ? 409 HOH A O    1 
HETATM 4438 O O    . HOH B 2 .   ? -28.96367 -35.43111 1.94225   1.000 37.92815  ? 410 HOH A O    1 
HETATM 4439 O O    . HOH B 2 .   ? -31.19575 -37.20630 10.53924  1.000 43.95629  ? 411 HOH A O    1 
HETATM 4440 O O    . HOH B 2 .   ? -26.11757 -28.06374 1.88566   1.000 31.67236  ? 412 HOH A O    1 
HETATM 4441 O O    . HOH B 2 .   ? -25.79014 -45.01850 -4.66029  1.000 48.92052  ? 413 HOH A O    1 
HETATM 4442 O O    . HOH B 2 .   ? -30.47371 -38.07029 2.30540   1.000 40.90527  ? 414 HOH A O    1 
HETATM 4443 O O    . HOH B 2 .   ? -14.96243 -26.87466 25.32697  1.000 34.72558  ? 415 HOH A O    1 
HETATM 4444 O O    . HOH B 2 .   ? -9.54251  -29.28213 28.86329  1.000 38.37730  ? 416 HOH A O    1 
HETATM 4445 O O    . HOH B 2 .   ? -4.13817  -24.81346 8.42611   1.000 46.99224  ? 417 HOH A O    1 
HETATM 4446 O O    . HOH B 2 .   ? -27.58476 -3.08723  40.08740  1.000 58.99267  ? 418 HOH A O    1 
HETATM 4447 O O    . HOH B 2 .   ? -26.51817 -16.87141 17.81071  1.000 34.65615  ? 419 HOH A O    1 
HETATM 4448 O O    . HOH B 2 .   ? -26.17837 -19.74909 40.00139  1.000 42.60125  ? 420 HOH A O    1 
HETATM 4449 O O    . HOH B 2 .   ? -28.38311 -42.17483 0.50081   1.000 44.33097  ? 421 HOH A O    1 
HETATM 4450 O O    . HOH B 2 .   ? -28.55208 -13.62039 24.31070  1.000 41.10385  ? 422 HOH A O    1 
HETATM 4451 O O    . HOH B 2 .   ? -27.78692 -24.32360 6.39165   1.000 31.96649  ? 423 HOH A O    1 
HETATM 4452 O O    . HOH B 2 .   ? -21.20815 -45.39538 14.26446  1.000 43.34184  ? 424 HOH A O    1 
HETATM 4453 O O    . HOH B 2 .   ? -18.77946 -37.38800 -8.99606  1.000 46.10735  ? 425 HOH A O    1 
HETATM 4454 O O    . HOH B 2 .   ? -32.07020 -33.28155 9.55870   1.000 46.68920  ? 426 HOH A O    1 
HETATM 4455 O O    . HOH B 2 .   ? -23.71822 -13.67679 26.30933  1.000 35.73662  ? 427 HOH A O    1 
HETATM 4456 O O    . HOH B 2 .   ? -21.30719 -19.77133 26.57296  1.000 29.96379  ? 428 HOH A O    1 
HETATM 4457 O O    . HOH B 2 .   ? -21.20180 -23.70443 10.20383  1.000 30.35046  ? 429 HOH A O    1 
HETATM 4458 O O    . HOH B 2 .   ? -23.56813 -34.11331 16.17104  1.000 29.27095  ? 430 HOH A O    1 
HETATM 4459 O O    . HOH B 2 .   ? -14.69946 -6.37985  22.63518  1.000 35.92770  ? 431 HOH A O    1 
HETATM 4460 O O    . HOH B 2 .   ? -27.21504 -6.89332  22.56838  1.000 44.35291  ? 432 HOH A O    1 
HETATM 4461 O O    . HOH B 2 .   ? -13.88282 -12.80877 19.67688  1.000 39.22261  ? 433 HOH A O    1 
HETATM 4462 O O    . HOH B 2 .   ? -19.56033 -31.59386 22.12290  1.000 28.59953  ? 434 HOH A O    1 
HETATM 4463 O O    . HOH B 2 .   ? -10.42429 -24.35142 29.96663  1.000 40.12143  ? 435 HOH A O    1 
HETATM 4464 O O    . HOH B 2 .   ? -17.72574 -25.68419 27.70586  1.000 36.46120  ? 436 HOH A O    1 
HETATM 4465 O O    . HOH B 2 .   ? -27.47263 -28.65893 6.34602   1.000 29.87258  ? 437 HOH A O    1 
HETATM 4466 O O    . HOH B 2 .   ? -14.06921 -15.95877 27.18334  1.000 31.17374  ? 438 HOH A O    1 
HETATM 4467 O O    . HOH B 2 .   ? -18.37190 -7.25056  18.73437  1.000 39.66321  ? 439 HOH A O    1 
HETATM 4468 O O    . HOH B 2 .   ? -27.25791 -26.87458 4.29971   1.000 30.52279  ? 440 HOH A O    1 
HETATM 4469 O O    . HOH B 2 .   ? -12.90263 -10.00033 20.87612  1.000 43.65310  ? 441 HOH A O    1 
HETATM 4470 O O    . HOH B 2 .   ? -25.75856 -28.04975 -1.49644  1.000 35.44889  ? 442 HOH A O    1 
HETATM 4471 O O    . HOH B 2 .   ? -12.23248 -22.90364 25.75783  1.000 34.62259  ? 443 HOH A O    1 
HETATM 4472 O O    . HOH B 2 .   ? -28.27073 -40.80904 -3.94138  1.000 43.00912  ? 444 HOH A O    1 
HETATM 4473 O O    . HOH B 2 .   ? -20.39725 -31.94998 2.11012   1.000 31.33749  ? 445 HOH A O    1 
HETATM 4474 O O    . HOH B 2 .   ? -24.54295 -32.48831 -10.36327 1.000 40.99974  ? 446 HOH A O    1 
HETATM 4475 O O    . HOH B 2 .   ? -3.20480  -21.87578 23.88586  1.000 40.69785  ? 447 HOH A O    1 
HETATM 4476 O O    . HOH B 2 .   ? -29.21247 -26.72290 9.14925   1.000 34.07310  ? 448 HOH A O    1 
HETATM 4477 O O    . HOH B 2 .   ? -6.39914  -14.40918 27.63593  1.000 39.11789  ? 449 HOH A O    1 
HETATM 4478 O O    . HOH B 2 .   ? -31.38728 -34.79496 11.02889  1.000 43.54436  ? 450 HOH A O    1 
HETATM 4479 O O    . HOH B 2 .   ? -6.19099  -24.45830 22.01769  1.000 34.99499  ? 451 HOH A O    1 
HETATM 4480 O O    . HOH B 2 .   ? -12.01357 -6.19210  22.67024  1.000 38.72702  ? 452 HOH A O    1 
HETATM 4481 O O    . HOH B 2 .   ? -27.17363 -44.31741 -1.36015  1.000 45.08635  ? 453 HOH A O    1 
HETATM 4482 O O    . HOH B 2 .   ? -14.19797 -25.52576 1.01544   1.000 39.96726  ? 454 HOH A O    1 
HETATM 4483 O O    . HOH B 2 .   ? -19.04777 -26.11422 25.55714  1.000 38.25511  ? 455 HOH A O    1 
HETATM 4484 O O    . HOH B 2 .   ? -17.56375 -14.68113 10.96271  1.000 35.96325  ? 456 HOH A O    1 
HETATM 4485 O O    . HOH B 2 .   ? -31.36043 -36.97491 4.56868   1.000 38.87551  ? 457 HOH A O    1 
HETATM 4486 O O    . HOH B 2 .   ? -15.62908 -26.71351 -0.50801  1.000 48.33134  ? 458 HOH A O    1 
HETATM 4487 O O    . HOH B 2 .   ? -10.14355 -23.90361 27.34162  1.000 36.90785  ? 459 HOH A O    1 
HETATM 4488 O O    . HOH B 2 .   ? -14.05140 -44.55807 25.99451  1.000 42.95266  ? 460 HOH A O    1 
HETATM 4489 O O    . HOH B 2 .   ? -19.57540 -12.62819 5.01536   1.000 53.45085  ? 461 HOH A O    1 
HETATM 4490 O O    . HOH B 2 .   ? -29.05082 -24.30419 15.11672  1.000 38.51736  ? 462 HOH A O    1 
HETATM 4491 O O    . HOH B 2 .   ? -16.16813 -43.58120 -8.25350  1.000 60.96101  ? 463 HOH A O    1 
HETATM 4492 O O    . HOH B 2 .   ? -3.64630  -19.26826 25.22391  1.000 41.49978  ? 464 HOH A O    1 
HETATM 4493 O O    . HOH B 2 .   ? -20.02969 -52.42961 -4.84157  1.000 65.61791  ? 465 HOH A O    1 
HETATM 4494 O O    . HOH B 2 .   ? -26.046   -17.460   3.838     1.000 39.33054  ? 466 HOH A O    1 
HETATM 4495 O O    . HOH B 2 .   ? -4.41125  -26.00481 22.05212  0.50  35.27603  ? 467 HOH A O    1 
HETATM 4496 O O    . HOH B 2 .   ? -26.48058 -38.72837 -12.97452 1.000 43.80448  ? 468 HOH A O    1 
HETATM 4497 O O    . HOH B 2 .   ? -27.97107 -27.79072 -0.05668  1.000 40.22297  ? 469 HOH A O    1 
HETATM 4498 O O    . HOH B 2 .   ? -23.49239 -18.86474 25.64646  1.000 39.12245  ? 470 HOH A O    1 
HETATM 4499 O O    . HOH B 2 .   ? -26.22186 -40.88971 13.73008  1.000 39.09641  ? 471 HOH A O    1 
HETATM 4500 O O    . HOH B 2 .   ? -28.12979 -43.59376 -3.93273  1.000 44.09916  ? 472 HOH A O    1 
HETATM 4501 O O    . HOH B 2 .   ? -29.39621 -40.70645 -1.10274  1.000 38.18301  ? 473 HOH A O    1 
HETATM 4502 O O    . HOH B 2 .   ? -4.41125  -19.74996 22.05212  0.50  40.52937  ? 474 HOH A O    1 
HETATM 4503 O O    . HOH B 2 .   ? -15.29525 -3.50355  21.66354  1.000 41.57237  ? 475 HOH A O    1 
# 
