data_9BNV
# 
_entry.id   9BNV 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BNV         pdb_00009bnv 10.2210/pdb9bnv/pdb 
WWPDB D_1000283650 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-12 ? 
2 'Structure model' 1 1 2025-03-12 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
_pdbx_audit_revision_category.ordinal             1 
_pdbx_audit_revision_category.revision_ordinal    2 
_pdbx_audit_revision_category.data_content_type   'Structure model' 
_pdbx_audit_revision_category.category            citation 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
5 2 'Structure model' '_citation.title'                   
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BNV 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-03 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              karen.anderson@yale.edu 
_pdbx_contact_author.name_first         Karen 
_pdbx_contact_author.name_last          Anderson 
_pdbx_contact_author.name_mi            S 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3433-0780 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Papini, C.'     1 0000-0002-6098-4959 
'Kenneson, J.'   2 ?                   
'Anderson, K.S.' 3 0000-0003-3433-0780 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acs Bio Med Chem Au' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2694-2437 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            5 
_citation.language                  ? 
_citation.page_first                215 
_citation.page_last                 226 
_citation.title                     
'Exploring Possible Drug-Resistant Variants of SARS-CoV-2 Main Protease (M pro ) with Noncovalent Preclinical Candidate, Mpro61.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acsbiomedchemau.4c00109 
_citation.pdbx_database_id_PubMed   39990941 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kenneson, J.R.'  1 ? 
primary 'Papini, C.'      2 ? 
primary 'Tang, S.'        3 ? 
primary 'Huynh, K.'       4 ? 
primary 'Zhang, C.H.'     5 ? 
primary 'Jorgensen, W.L.' 6 ? 
primary 'Anderson, K.S.'  7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man '3C-like proteinase nsp5' 33853.598 1   3.4.22.69 ? ? ? 
2 water   nat water                     18.015    170 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHVGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHVGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   GLY n 
1 3   PHE n 
1 4   ARG n 
1 5   LYS n 
1 6   MET n 
1 7   ALA n 
1 8   PHE n 
1 9   PRO n 
1 10  SER n 
1 11  GLY n 
1 12  LYS n 
1 13  VAL n 
1 14  GLU n 
1 15  GLY n 
1 16  CYS n 
1 17  MET n 
1 18  VAL n 
1 19  GLN n 
1 20  VAL n 
1 21  THR n 
1 22  CYS n 
1 23  GLY n 
1 24  THR n 
1 25  THR n 
1 26  THR n 
1 27  LEU n 
1 28  ASN n 
1 29  GLY n 
1 30  LEU n 
1 31  TRP n 
1 32  LEU n 
1 33  ASP n 
1 34  ASP n 
1 35  VAL n 
1 36  VAL n 
1 37  TYR n 
1 38  CYS n 
1 39  PRO n 
1 40  ARG n 
1 41  HIS n 
1 42  VAL n 
1 43  ILE n 
1 44  CYS n 
1 45  THR n 
1 46  SER n 
1 47  GLU n 
1 48  ASP n 
1 49  MET n 
1 50  LEU n 
1 51  ASN n 
1 52  PRO n 
1 53  ASN n 
1 54  TYR n 
1 55  GLU n 
1 56  ASP n 
1 57  LEU n 
1 58  LEU n 
1 59  ILE n 
1 60  ARG n 
1 61  LYS n 
1 62  SER n 
1 63  ASN n 
1 64  HIS n 
1 65  ASN n 
1 66  PHE n 
1 67  LEU n 
1 68  VAL n 
1 69  GLN n 
1 70  ALA n 
1 71  GLY n 
1 72  ASN n 
1 73  VAL n 
1 74  GLN n 
1 75  LEU n 
1 76  ARG n 
1 77  VAL n 
1 78  ILE n 
1 79  GLY n 
1 80  HIS n 
1 81  SER n 
1 82  MET n 
1 83  GLN n 
1 84  ASN n 
1 85  CYS n 
1 86  VAL n 
1 87  LEU n 
1 88  LYS n 
1 89  LEU n 
1 90  LYS n 
1 91  VAL n 
1 92  ASP n 
1 93  THR n 
1 94  ALA n 
1 95  ASN n 
1 96  PRO n 
1 97  LYS n 
1 98  THR n 
1 99  PRO n 
1 100 LYS n 
1 101 TYR n 
1 102 LYS n 
1 103 PHE n 
1 104 VAL n 
1 105 ARG n 
1 106 ILE n 
1 107 GLN n 
1 108 PRO n 
1 109 GLY n 
1 110 GLN n 
1 111 THR n 
1 112 PHE n 
1 113 SER n 
1 114 VAL n 
1 115 LEU n 
1 116 ALA n 
1 117 CYS n 
1 118 TYR n 
1 119 ASN n 
1 120 GLY n 
1 121 SER n 
1 122 PRO n 
1 123 SER n 
1 124 GLY n 
1 125 VAL n 
1 126 TYR n 
1 127 GLN n 
1 128 CYS n 
1 129 ALA n 
1 130 MET n 
1 131 ARG n 
1 132 PRO n 
1 133 ASN n 
1 134 PHE n 
1 135 THR n 
1 136 ILE n 
1 137 LYS n 
1 138 GLY n 
1 139 SER n 
1 140 PHE n 
1 141 LEU n 
1 142 ASN n 
1 143 GLY n 
1 144 SER n 
1 145 CYS n 
1 146 GLY n 
1 147 SER n 
1 148 VAL n 
1 149 GLY n 
1 150 PHE n 
1 151 ASN n 
1 152 ILE n 
1 153 ASP n 
1 154 TYR n 
1 155 ASP n 
1 156 CYS n 
1 157 VAL n 
1 158 SER n 
1 159 PHE n 
1 160 CYS n 
1 161 TYR n 
1 162 MET n 
1 163 HIS n 
1 164 HIS n 
1 165 MET n 
1 166 GLU n 
1 167 LEU n 
1 168 PRO n 
1 169 THR n 
1 170 GLY n 
1 171 VAL n 
1 172 HIS n 
1 173 VAL n 
1 174 GLY n 
1 175 THR n 
1 176 ASP n 
1 177 LEU n 
1 178 GLU n 
1 179 GLY n 
1 180 ASN n 
1 181 PHE n 
1 182 TYR n 
1 183 GLY n 
1 184 PRO n 
1 185 PHE n 
1 186 VAL n 
1 187 ASP n 
1 188 ARG n 
1 189 GLN n 
1 190 THR n 
1 191 ALA n 
1 192 GLN n 
1 193 ALA n 
1 194 ALA n 
1 195 GLY n 
1 196 THR n 
1 197 ASP n 
1 198 THR n 
1 199 THR n 
1 200 ILE n 
1 201 THR n 
1 202 VAL n 
1 203 ASN n 
1 204 VAL n 
1 205 LEU n 
1 206 ALA n 
1 207 TRP n 
1 208 LEU n 
1 209 TYR n 
1 210 ALA n 
1 211 ALA n 
1 212 VAL n 
1 213 ILE n 
1 214 ASN n 
1 215 GLY n 
1 216 ASP n 
1 217 ARG n 
1 218 TRP n 
1 219 PHE n 
1 220 LEU n 
1 221 ASN n 
1 222 ARG n 
1 223 PHE n 
1 224 THR n 
1 225 THR n 
1 226 THR n 
1 227 LEU n 
1 228 ASN n 
1 229 ASP n 
1 230 PHE n 
1 231 ASN n 
1 232 LEU n 
1 233 VAL n 
1 234 ALA n 
1 235 MET n 
1 236 LYS n 
1 237 TYR n 
1 238 ASN n 
1 239 TYR n 
1 240 GLU n 
1 241 PRO n 
1 242 LEU n 
1 243 THR n 
1 244 GLN n 
1 245 ASP n 
1 246 HIS n 
1 247 VAL n 
1 248 ASP n 
1 249 ILE n 
1 250 LEU n 
1 251 GLY n 
1 252 PRO n 
1 253 LEU n 
1 254 SER n 
1 255 ALA n 
1 256 GLN n 
1 257 THR n 
1 258 GLY n 
1 259 ILE n 
1 260 ALA n 
1 261 VAL n 
1 262 LEU n 
1 263 ASP n 
1 264 MET n 
1 265 CYS n 
1 266 ALA n 
1 267 SER n 
1 268 LEU n 
1 269 LYS n 
1 270 GLU n 
1 271 LEU n 
1 272 LEU n 
1 273 GLN n 
1 274 ASN n 
1 275 GLY n 
1 276 MET n 
1 277 ASN n 
1 278 GLY n 
1 279 ARG n 
1 280 THR n 
1 281 ILE n 
1 282 LEU n 
1 283 GLY n 
1 284 SER n 
1 285 ALA n 
1 286 LEU n 
1 287 LEU n 
1 288 GLU n 
1 289 ASP n 
1 290 GLU n 
1 291 PHE n 
1 292 THR n 
1 293 PRO n 
1 294 PHE n 
1 295 ASP n 
1 296 VAL n 
1 297 VAL n 
1 298 ARG n 
1 299 GLN n 
1 300 CYS n 
1 301 SER n 
1 302 GLY n 
1 303 VAL n 
1 304 THR n 
1 305 PHE n 
1 306 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   306 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'rep, 1a-1b' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1   1   SER SER A . n 
A 1 2   GLY 2   2   2   GLY GLY A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ARG 4   4   4   ARG ARG A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   MET 6   6   6   MET MET A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  CYS 16  16  16  CYS CYS A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  THR 21  21  21  THR THR A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  ASN 28  28  28  ASN ASN A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  TRP 31  31  31  TRP TRP A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  ASP 34  34  34  ASP ASP A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  CYS 38  38  38  CYS CYS A . n 
A 1 39  PRO 39  39  39  PRO PRO A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  CYS 44  44  44  CYS CYS A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  MET 49  49  49  MET MET A . n 
A 1 50  LEU 50  50  50  LEU LEU A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  ASP 56  56  56  ASP ASP A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  HIS 64  64  64  HIS HIS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  MET 82  82  82  MET MET A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  CYS 85  85  85  CYS CYS A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  ASP 92  92  92  ASP ASP A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  PRO 99  99  99  PRO PRO A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ARG 105 105 105 ARG ARG A . n 
A 1 106 ILE 106 106 106 ILE ILE A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 PHE 134 134 134 PHE PHE A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 CYS 145 145 145 CYS CYS A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 ASP 153 153 153 ASP ASP A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 CYS 156 156 156 CYS CYS A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 CYS 160 160 160 CYS CYS A . n 
A 1 161 TYR 161 161 161 TYR TYR A . n 
A 1 162 MET 162 162 162 MET MET A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 MET 165 165 165 MET MET A . n 
A 1 166 GLU 166 166 166 GLU GLU A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 HIS 172 172 172 HIS HIS A . n 
A 1 173 VAL 173 173 173 VAL VAL A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 GLN 189 189 189 GLN GLN A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 GLN 192 192 192 GLN GLN A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 ILE 200 200 200 ILE ILE A . n 
A 1 201 THR 201 201 201 THR THR A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 TRP 207 207 207 TRP TRP A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ARG 217 217 217 ARG ARG A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ASN 221 221 221 ASN ASN A . n 
A 1 222 ARG 222 222 222 ARG ARG A . n 
A 1 223 PHE 223 223 223 PHE PHE A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 MET 235 235 235 MET MET A . n 
A 1 236 LYS 236 236 236 LYS LYS A . n 
A 1 237 TYR 237 237 237 TYR TYR A . n 
A 1 238 ASN 238 238 238 ASN ASN A . n 
A 1 239 TYR 239 239 239 TYR TYR A . n 
A 1 240 GLU 240 240 240 GLU GLU A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 THR 243 243 243 THR THR A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 ASP 248 248 248 ASP ASP A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 THR 257 257 257 THR THR A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 CYS 265 265 265 CYS CYS A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 LYS 269 269 269 LYS LYS A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 ASN 274 274 274 ASN ASN A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 ASN 277 277 277 ASN ASN A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 SER 284 284 284 SER SER A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 PHE 291 291 291 PHE PHE A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 PRO 293 293 293 PRO PRO A . n 
A 1 294 PHE 294 294 294 PHE PHE A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 VAL 296 296 296 VAL VAL A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLN 299 299 299 GLN GLN A . n 
A 1 300 CYS 300 300 300 CYS CYS A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 GLY 302 302 302 GLY GLY A . n 
A 1 303 VAL 303 303 ?   ?   ?   A . n 
A 1 304 THR 304 304 ?   ?   ?   A . n 
A 1 305 PHE 305 305 ?   ?   ?   A . n 
A 1 306 GLN 306 306 ?   ?   ?   A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 HOH 1   401 125 HOH HOH A . 
B 2 HOH 2   402 45  HOH HOH A . 
B 2 HOH 3   403 6   HOH HOH A . 
B 2 HOH 4   404 37  HOH HOH A . 
B 2 HOH 5   405 19  HOH HOH A . 
B 2 HOH 6   406 13  HOH HOH A . 
B 2 HOH 7   407 130 HOH HOH A . 
B 2 HOH 8   408 62  HOH HOH A . 
B 2 HOH 9   409 39  HOH HOH A . 
B 2 HOH 10  410 132 HOH HOH A . 
B 2 HOH 11  411 108 HOH HOH A . 
B 2 HOH 12  412 28  HOH HOH A . 
B 2 HOH 13  413 133 HOH HOH A . 
B 2 HOH 14  414 86  HOH HOH A . 
B 2 HOH 15  415 164 HOH HOH A . 
B 2 HOH 16  416 144 HOH HOH A . 
B 2 HOH 17  417 44  HOH HOH A . 
B 2 HOH 18  418 74  HOH HOH A . 
B 2 HOH 19  419 81  HOH HOH A . 
B 2 HOH 20  420 38  HOH HOH A . 
B 2 HOH 21  421 12  HOH HOH A . 
B 2 HOH 22  422 173 HOH HOH A . 
B 2 HOH 23  423 5   HOH HOH A . 
B 2 HOH 24  424 169 HOH HOH A . 
B 2 HOH 25  425 9   HOH HOH A . 
B 2 HOH 26  426 155 HOH HOH A . 
B 2 HOH 27  427 78  HOH HOH A . 
B 2 HOH 28  428 94  HOH HOH A . 
B 2 HOH 29  429 105 HOH HOH A . 
B 2 HOH 30  430 119 HOH HOH A . 
B 2 HOH 31  431 178 HOH HOH A . 
B 2 HOH 32  432 122 HOH HOH A . 
B 2 HOH 33  433 46  HOH HOH A . 
B 2 HOH 34  434 48  HOH HOH A . 
B 2 HOH 35  435 88  HOH HOH A . 
B 2 HOH 36  436 2   HOH HOH A . 
B 2 HOH 37  437 66  HOH HOH A . 
B 2 HOH 38  438 31  HOH HOH A . 
B 2 HOH 39  439 52  HOH HOH A . 
B 2 HOH 40  440 61  HOH HOH A . 
B 2 HOH 41  441 82  HOH HOH A . 
B 2 HOH 42  442 40  HOH HOH A . 
B 2 HOH 43  443 107 HOH HOH A . 
B 2 HOH 44  444 70  HOH HOH A . 
B 2 HOH 45  445 102 HOH HOH A . 
B 2 HOH 46  446 14  HOH HOH A . 
B 2 HOH 47  447 3   HOH HOH A . 
B 2 HOH 48  448 34  HOH HOH A . 
B 2 HOH 49  449 121 HOH HOH A . 
B 2 HOH 50  450 4   HOH HOH A . 
B 2 HOH 51  451 98  HOH HOH A . 
B 2 HOH 52  452 67  HOH HOH A . 
B 2 HOH 53  453 158 HOH HOH A . 
B 2 HOH 54  454 60  HOH HOH A . 
B 2 HOH 55  455 53  HOH HOH A . 
B 2 HOH 56  456 101 HOH HOH A . 
B 2 HOH 57  457 141 HOH HOH A . 
B 2 HOH 58  458 24  HOH HOH A . 
B 2 HOH 59  459 18  HOH HOH A . 
B 2 HOH 60  460 1   HOH HOH A . 
B 2 HOH 61  461 58  HOH HOH A . 
B 2 HOH 62  462 83  HOH HOH A . 
B 2 HOH 63  463 42  HOH HOH A . 
B 2 HOH 64  464 85  HOH HOH A . 
B 2 HOH 65  465 22  HOH HOH A . 
B 2 HOH 66  466 168 HOH HOH A . 
B 2 HOH 67  467 36  HOH HOH A . 
B 2 HOH 68  468 163 HOH HOH A . 
B 2 HOH 69  469 166 HOH HOH A . 
B 2 HOH 70  470 134 HOH HOH A . 
B 2 HOH 71  471 160 HOH HOH A . 
B 2 HOH 72  472 177 HOH HOH A . 
B 2 HOH 73  473 57  HOH HOH A . 
B 2 HOH 74  474 65  HOH HOH A . 
B 2 HOH 75  475 21  HOH HOH A . 
B 2 HOH 76  476 8   HOH HOH A . 
B 2 HOH 77  477 80  HOH HOH A . 
B 2 HOH 78  478 77  HOH HOH A . 
B 2 HOH 79  479 116 HOH HOH A . 
B 2 HOH 80  480 152 HOH HOH A . 
B 2 HOH 81  481 148 HOH HOH A . 
B 2 HOH 82  482 69  HOH HOH A . 
B 2 HOH 83  483 7   HOH HOH A . 
B 2 HOH 84  484 63  HOH HOH A . 
B 2 HOH 85  485 93  HOH HOH A . 
B 2 HOH 86  486 79  HOH HOH A . 
B 2 HOH 87  487 97  HOH HOH A . 
B 2 HOH 88  488 11  HOH HOH A . 
B 2 HOH 89  489 35  HOH HOH A . 
B 2 HOH 90  490 174 HOH HOH A . 
B 2 HOH 91  491 114 HOH HOH A . 
B 2 HOH 92  492 96  HOH HOH A . 
B 2 HOH 93  493 143 HOH HOH A . 
B 2 HOH 94  494 115 HOH HOH A . 
B 2 HOH 95  495 135 HOH HOH A . 
B 2 HOH 96  496 43  HOH HOH A . 
B 2 HOH 97  497 33  HOH HOH A . 
B 2 HOH 98  498 49  HOH HOH A . 
B 2 HOH 99  499 136 HOH HOH A . 
B 2 HOH 100 500 23  HOH HOH A . 
B 2 HOH 101 501 147 HOH HOH A . 
B 2 HOH 102 502 15  HOH HOH A . 
B 2 HOH 103 503 16  HOH HOH A . 
B 2 HOH 104 504 179 HOH HOH A . 
B 2 HOH 105 505 30  HOH HOH A . 
B 2 HOH 106 506 129 HOH HOH A . 
B 2 HOH 107 507 90  HOH HOH A . 
B 2 HOH 108 508 26  HOH HOH A . 
B 2 HOH 109 509 72  HOH HOH A . 
B 2 HOH 110 510 128 HOH HOH A . 
B 2 HOH 111 511 151 HOH HOH A . 
B 2 HOH 112 512 154 HOH HOH A . 
B 2 HOH 113 513 126 HOH HOH A . 
B 2 HOH 114 514 146 HOH HOH A . 
B 2 HOH 115 515 17  HOH HOH A . 
B 2 HOH 116 516 55  HOH HOH A . 
B 2 HOH 117 517 140 HOH HOH A . 
B 2 HOH 118 518 137 HOH HOH A . 
B 2 HOH 119 519 84  HOH HOH A . 
B 2 HOH 120 520 47  HOH HOH A . 
B 2 HOH 121 521 106 HOH HOH A . 
B 2 HOH 122 522 99  HOH HOH A . 
B 2 HOH 123 523 20  HOH HOH A . 
B 2 HOH 124 524 71  HOH HOH A . 
B 2 HOH 125 525 171 HOH HOH A . 
B 2 HOH 126 526 113 HOH HOH A . 
B 2 HOH 127 527 131 HOH HOH A . 
B 2 HOH 128 528 73  HOH HOH A . 
B 2 HOH 129 529 56  HOH HOH A . 
B 2 HOH 130 530 139 HOH HOH A . 
B 2 HOH 131 531 87  HOH HOH A . 
B 2 HOH 132 532 104 HOH HOH A . 
B 2 HOH 133 533 10  HOH HOH A . 
B 2 HOH 134 534 176 HOH HOH A . 
B 2 HOH 135 535 150 HOH HOH A . 
B 2 HOH 136 536 162 HOH HOH A . 
B 2 HOH 137 537 91  HOH HOH A . 
B 2 HOH 138 538 145 HOH HOH A . 
B 2 HOH 139 539 95  HOH HOH A . 
B 2 HOH 140 540 142 HOH HOH A . 
B 2 HOH 141 541 32  HOH HOH A . 
B 2 HOH 142 542 161 HOH HOH A . 
B 2 HOH 143 543 103 HOH HOH A . 
B 2 HOH 144 544 89  HOH HOH A . 
B 2 HOH 145 545 157 HOH HOH A . 
B 2 HOH 146 546 75  HOH HOH A . 
B 2 HOH 147 547 170 HOH HOH A . 
B 2 HOH 148 548 51  HOH HOH A . 
B 2 HOH 149 549 167 HOH HOH A . 
B 2 HOH 150 550 172 HOH HOH A . 
B 2 HOH 151 551 64  HOH HOH A . 
B 2 HOH 152 552 54  HOH HOH A . 
B 2 HOH 153 553 156 HOH HOH A . 
B 2 HOH 154 554 175 HOH HOH A . 
B 2 HOH 155 555 120 HOH HOH A . 
B 2 HOH 156 556 124 HOH HOH A . 
B 2 HOH 157 557 138 HOH HOH A . 
B 2 HOH 158 558 149 HOH HOH A . 
B 2 HOH 159 559 117 HOH HOH A . 
B 2 HOH 160 560 68  HOH HOH A . 
B 2 HOH 161 561 50  HOH HOH A . 
B 2 HOH 162 562 59  HOH HOH A . 
B 2 HOH 163 563 25  HOH HOH A . 
B 2 HOH 164 564 127 HOH HOH A . 
B 2 HOH 165 565 165 HOH HOH A . 
B 2 HOH 166 566 123 HOH HOH A . 
B 2 HOH 167 567 159 HOH HOH A . 
B 2 HOH 168 568 76  HOH HOH A . 
B 2 HOH 169 569 41  HOH HOH A . 
B 2 HOH 170 570 100 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A ARG 60  ? CG  ? A ARG 60  CG  
2  1 Y 1 A ARG 60  ? CD  ? A ARG 60  CD  
3  1 Y 1 A ARG 60  ? NE  ? A ARG 60  NE  
4  1 Y 1 A ARG 60  ? CZ  ? A ARG 60  CZ  
5  1 Y 1 A ARG 60  ? NH1 ? A ARG 60  NH1 
6  1 Y 1 A ARG 60  ? NH2 ? A ARG 60  NH2 
7  1 Y 1 A ASN 72  ? CG  ? A ASN 72  CG  
8  1 Y 1 A ASN 72  ? OD1 ? A ASN 72  OD1 
9  1 Y 1 A ASN 72  ? ND2 ? A ASN 72  ND2 
10 1 Y 1 A LEU 87  ? CG  ? A LEU 87  CG  
11 1 Y 1 A LEU 87  ? CD1 ? A LEU 87  CD1 
12 1 Y 1 A LEU 87  ? CD2 ? A LEU 87  CD2 
13 1 Y 1 A ASP 153 ? CG  ? A ASP 153 CG  
14 1 Y 1 A ASP 153 ? OD1 ? A ASP 153 OD1 
15 1 Y 1 A ASP 153 ? OD2 ? A ASP 153 OD2 
16 1 Y 1 A TYR 154 ? CG  ? A TYR 154 CG  
17 1 Y 1 A TYR 154 ? CD1 ? A TYR 154 CD1 
18 1 Y 1 A TYR 154 ? CD2 ? A TYR 154 CD2 
19 1 Y 1 A TYR 154 ? CE1 ? A TYR 154 CE1 
20 1 Y 1 A TYR 154 ? CE2 ? A TYR 154 CE2 
21 1 Y 1 A TYR 154 ? CZ  ? A TYR 154 CZ  
22 1 Y 1 A TYR 154 ? OH  ? A TYR 154 OH  
23 1 Y 1 A ASP 155 ? CG  ? A ASP 155 CG  
24 1 Y 1 A ASP 155 ? OD1 ? A ASP 155 OD1 
25 1 Y 1 A ASP 155 ? OD2 ? A ASP 155 OD2 
26 1 Y 1 A ARG 217 ? CG  ? A ARG 217 CG  
27 1 Y 1 A ARG 217 ? CD  ? A ARG 217 CD  
28 1 Y 1 A ARG 217 ? NE  ? A ARG 217 NE  
29 1 Y 1 A ARG 217 ? CZ  ? A ARG 217 CZ  
30 1 Y 1 A ARG 217 ? NH1 ? A ARG 217 NH1 
31 1 Y 1 A ARG 217 ? NH2 ? A ARG 217 NH2 
32 1 Y 1 A ARG 222 ? CG  ? A ARG 222 CG  
33 1 Y 1 A ARG 222 ? CD  ? A ARG 222 CD  
34 1 Y 1 A ARG 222 ? NE  ? A ARG 222 NE  
35 1 Y 1 A ARG 222 ? CZ  ? A ARG 222 CZ  
36 1 Y 1 A ARG 222 ? NH1 ? A ARG 222 NH1 
37 1 Y 1 A ARG 222 ? NH2 ? A ARG 222 NH2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   101.305 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BNV 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     114.654 
_cell.length_a_esd                 ? 
_cell.length_b                     53.649 
_cell.length_b_esd                 ? 
_cell.length_c                     44.743 
_cell.length_c_esd                 ? 
_cell.volume                       269877.543 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BNV 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y' 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BNV 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             1.99 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          38.28 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.0 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M Imidazole, 20% w/v Polyethylene glycol 6,000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            294 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-07-28 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.919764 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSLS-II BEAMLINE 17-ID-2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.919764 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID-2 
_diffrn_source.pdbx_synchrotron_site       NSLS-II 
# 
_reflns.B_iso_Wilson_estimate                          23.48 
_reflns.entry_id                                       9BNV 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.67 
_reflns.d_resolution_low                               31.70 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     27722 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           88.98 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.6 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          6.81 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.995 
_reflns.pdbx_CC_star                                   0.999 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.09533 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.67 
_reflns_shell.d_res_low                                     1.73 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           0.91 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2895 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               3.5 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.366 
_reflns_shell.pdbx_CC_star                                  0.732 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          94.54 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.541 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               29.88 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9BNV 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.67 
_refine.ls_d_res_low                             31.70 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     27547 
_refine.ls_number_reflns_R_free                  1368 
_refine.ls_number_reflns_R_work                  26179 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    89.00 
_refine.ls_percent_reflns_R_free                 4.97 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2045 
_refine.ls_R_factor_R_free                       0.2548 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2019 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 30.5596 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2522 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.67 
_refine_hist.d_res_low                        31.70 
_refine_hist.number_atoms_solvent             170 
_refine_hist.number_atoms_total               2468 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2298 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0107 ? 2360 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.2607 ? 3214 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0640 ? 367  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0115 ? 418  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 6.6046 ? 323  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.67 1.73  . . 152 2742 94.54 . . . . 0.3150 . . . . . . . . . . . 0.3529 
'X-RAY DIFFRACTION' 1.73 1.80  . . 141 2911 99.28 . . . . 0.3014 . . . . . . . . . . . 0.3853 
'X-RAY DIFFRACTION' 1.80 1.87  . . 108 2517 99.17 . . . . 0.2814 . . . . . . . . . . . 0.2944 
'X-RAY DIFFRACTION' 1.90 1.98  . . 58  874  35.42 . . . . 0.2631 . . . . . . . . . . . 0.2976 
'X-RAY DIFFRACTION' 1.98 2.11  . . 163 2853 98.27 . . . . 0.2404 . . . . . . . . . . . 0.3101 
'X-RAY DIFFRACTION' 2.11 2.27  . . 124 2461 83.47 . . . . 0.2297 . . . . . . . . . . . 0.3053 
'X-RAY DIFFRACTION' 2.27 2.50  . . 169 2909 99.77 . . . . 0.2158 . . . . . . . . . . . 0.2849 
'X-RAY DIFFRACTION' 2.50 2.86  . . 141 2946 99.58 . . . . 0.2140 . . . . . . . . . . . 0.2602 
'X-RAY DIFFRACTION' 2.86 3.60  . . 139 2963 99.58 . . . . 0.1890 . . . . . . . . . . . 0.2509 
'X-RAY DIFFRACTION' 3.60 31.70 . . 173 3003 99.65 . . . . 0.1578 . . . . . . . . . . . 0.2006 
# 
_struct.entry_id                     9BNV 
_struct.title                        'Crystal Structure of A173V SARS-CoV-2 Main Protease' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BNV 
_struct_keywords.text            'Hydrolase, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1AB_SARS2 
_struct_ref.pdbx_db_accession          P0DTD1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_struct_ref.pdbx_align_begin           3264 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9BNV 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 306 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P0DTD1 
_struct_ref_seq.db_align_beg                  3264 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3569 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       306 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             9BNV 
_struct_ref_seq_dif.mon_id                       VAL 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      173 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   P0DTD1 
_struct_ref_seq_dif.db_mon_id                    ALA 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          3436 
_struct_ref_seq_dif.details                      'engineered mutation' 
_struct_ref_seq_dif.pdbx_auth_seq_num            173 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2740  ? 
1 MORE         -14   ? 
1 'SSA (A^2)'  24800 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000 0.0000000000 0.0000000000  0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000  
2 'crystal symmetry operation' 2_556 -x,y,-z+1 -1.0000000000 0.0000000000 0.0000000000 -8.7710471705 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 43.8748764162 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 10  ? GLY A 15  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 41  ? CYS A 44  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 GLU A 47  ? ASN A 51  ? GLU A 47  ASN A 51  5 ? 5  
HELX_P HELX_P4  AA4 ASN A 53  ? ARG A 60  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P5  AA5 SER A 62  ? HIS A 64  ? SER A 62  HIS A 64  5 ? 3  
HELX_P HELX_P6  AA6 ILE A 200 ? ASN A 214 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P7  AA7 THR A 226 ? TYR A 237 ? THR A 226 TYR A 237 1 ? 12 
HELX_P HELX_P8  AA8 THR A 243 ? LEU A 250 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P9  AA9 LEU A 250 ? GLY A 258 ? LEU A 250 GLY A 258 1 ? 9  
HELX_P HELX_P10 AB1 ALA A 260 ? GLY A 275 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P11 AB2 THR A 292 ? GLY A 302 ? THR A 292 GLY A 302 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 73  ? LEU A 75  ? VAL A 73  LEU A 75  
AA1 2 PHE A 66  ? ALA A 70  ? PHE A 66  ALA A 70  
AA1 3 MET A 17  ? CYS A 22  ? MET A 17  CYS A 22  
AA1 4 THR A 25  ? LEU A 32  ? THR A 25  LEU A 32  
AA1 5 VAL A 35  ? PRO A 39  ? VAL A 35  PRO A 39  
AA1 6 VAL A 86  ? VAL A 91  ? VAL A 86  VAL A 91  
AA1 7 VAL A 77  ? GLN A 83  ? VAL A 77  GLN A 83  
AA2 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA2 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA2 3 VAL A 148 ? ASP A 153 ? VAL A 148 ASP A 153 
AA2 4 THR A 111 ? TYR A 118 ? THR A 111 TYR A 118 
AA2 5 SER A 121 ? ALA A 129 ? SER A 121 ALA A 129 
AA3 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA3 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA3 3 HIS A 172 ? THR A 175 ? HIS A 172 THR A 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O LEU A 75  ? O LEU A 75  N VAL A 68  ? N VAL A 68  
AA1 2 3 O LEU A 67  ? O LEU A 67  N THR A 21  ? N THR A 21  
AA1 3 4 N VAL A 20  ? N VAL A 20  O LEU A 27  ? O LEU A 27  
AA1 4 5 N LEU A 30  ? N LEU A 30  O TYR A 37  ? O TYR A 37  
AA1 5 6 N CYS A 38  ? N CYS A 38  O LEU A 87  ? O LEU A 87  
AA1 6 7 O LYS A 88  ? O LYS A 88  N SER A 81  ? N SER A 81  
AA2 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA2 2 3 O SER A 158 ? O SER A 158 N ASN A 151 ? N ASN A 151 
AA2 3 4 O PHE A 150 ? O PHE A 150 N SER A 113 ? N SER A 113 
AA2 4 5 N ALA A 116 ? N ALA A 116 O SER A 123 ? O SER A 123 
AA3 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA3 2 3 N MET A 165 ? N MET A 165 O VAL A 173 ? O VAL A 173 
# 
_pdbx_entry_details.entry_id                   9BNV 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 50.97   -134.79 
2 1 ASN A 51  ? ? -164.70 70.94   
3 1 ASN A 84  ? ? 50.89   -120.04 
4 1 TYR A 154 ? ? 62.69   -101.68 
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    A 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     569 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   B 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 -x,y,-z         
3 x+1/2,y+1/2,z   
4 -x+1/2,y+1/2,-z 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A VAL 303 ? A VAL 303 
2 1 Y 1 A THR 304 ? A THR 304 
3 1 Y 1 A PHE 305 ? A PHE 305 
4 1 Y 1 A GLN 306 ? A GLN 306 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' 'P30 GM133893' 1 
'Department of Energy (DOE, United States)'                                                'United States' KP1607011      2 
'Other government'                                                                         ?               DE-SC0012704   3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7NF5 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'C 1 2 1' 
_space_group.name_Hall        'C 2y' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9BNV 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.008722 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.001744 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.018640 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.022792 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . SER A 1 1   ? -1.42463  -22.31762 38.82805  1.000 39.00437 ? 1   SER A N    1 
ATOM   2    C CA   . SER A 1 1   ? -2.11226  -21.20474 38.12849  1.000 40.21535 ? 1   SER A CA   1 
ATOM   3    C C    . SER A 1 1   ? -1.67788  -21.04650 36.67474  1.000 40.21298 ? 1   SER A C    1 
ATOM   4    O O    . SER A 1 1   ? -0.94401  -21.89458 36.13448  1.000 32.37789 ? 1   SER A O    1 
ATOM   5    C CB   . SER A 1 1   ? -1.86557  -19.88299 38.86040  1.000 40.93571 ? 1   SER A CB   1 
ATOM   6    O OG   . SER A 1 1   ? -0.55462  -19.39443 38.58256  1.000 51.06408 ? 1   SER A OG   1 
ATOM   7    H H1   . SER A 1 1   ? -1.98611  -23.00113 38.92143  1.000 46.80524 ? 1   SER A H1   1 
ATOM   8    H H2   . SER A 1 1   ? -0.71825  -22.57577 38.35214  1.000 46.80524 ? 1   SER A H2   1 
ATOM   9    H H3   . SER A 1 1   ? -1.15613  -22.04290 39.63131  1.000 46.80524 ? 1   SER A H3   1 
ATOM   10   H HA   . SER A 1 1   ? -3.06010  -21.41049 38.12703  1.000 48.25842 ? 1   SER A HA   1 
ATOM   11   H HB2  . SER A 1 1   ? -2.51755  -19.22940 38.56367  1.000 49.12285 ? 1   SER A HB2  1 
ATOM   12   H HB3  . SER A 1 1   ? -1.95379  -20.02870 39.81589  1.000 49.12285 ? 1   SER A HB3  1 
ATOM   13   H HG   . SER A 1 1   ? -0.42702  -18.66922 38.98762  1.000 61.27690 ? 1   SER A HG   1 
ATOM   14   N N    . GLY A 1 2   ? -2.10854  -19.94047 36.07327  1.000 38.07119 ? 2   GLY A N    1 
ATOM   15   C CA   . GLY A 1 2   ? -1.99922  -19.71651 34.65345  1.000 35.26747 ? 2   GLY A CA   1 
ATOM   16   C C    . GLY A 1 2   ? -3.26263  -20.12606 33.91075  1.000 30.19188 ? 2   GLY A C    1 
ATOM   17   O O    . GLY A 1 2   ? -4.06113  -20.95997 34.36896  1.000 37.90488 ? 2   GLY A O    1 
ATOM   18   H H    . GLY A 1 2   ? -2.47921  -19.28602 36.48955  1.000 45.68543 ? 2   GLY A H    1 
ATOM   19   H HA2  . GLY A 1 2   ? -1.83691  -18.77527 34.48709  1.000 42.32096 ? 2   GLY A HA2  1 
ATOM   20   H HA3  . GLY A 1 2   ? -1.25669  -20.23270 34.30239  1.000 42.32096 ? 2   GLY A HA3  1 
ATOM   21   N N    . PHE A 1 3   ? -3.46673  -19.49851 32.76507  1.000 29.94990 ? 3   PHE A N    1 
ATOM   22   C CA   . PHE A 1 3   ? -4.67925  -19.75000 31.98548  1.000 34.43712 ? 3   PHE A CA   1 
ATOM   23   C C    . PHE A 1 3   ? -4.34464  -19.86182 30.51453  1.000 28.09987 ? 3   PHE A C    1 
ATOM   24   O O    . PHE A 1 3   ? -3.92519  -18.90010 29.88327  1.000 29.52812 ? 3   PHE A O    1 
ATOM   25   C CB   . PHE A 1 3   ? -5.72420  -18.65296 32.19379  1.000 31.03479 ? 3   PHE A CB   1 
ATOM   26   C CG   . PHE A 1 3   ? -7.12075  -19.13094 31.98700  1.000 30.12959 ? 3   PHE A CG   1 
ATOM   27   C CD1  . PHE A 1 3   ? -7.67432  -20.05592 32.85924  1.000 29.84018 ? 3   PHE A CD1  1 
ATOM   28   C CD2  . PHE A 1 3   ? -7.85970  -18.69785 30.89201  1.000 30.03781 ? 3   PHE A CD2  1 
ATOM   29   C CE1  . PHE A 1 3   ? -8.95690  -20.50583 32.68551  1.000 36.53989 ? 3   PHE A CE1  1 
ATOM   30   C CE2  . PHE A 1 3   ? -9.15128  -19.14977 30.70727  1.000 34.47974 ? 3   PHE A CE2  1 
ATOM   31   C CZ   . PHE A 1 3   ? -9.68687  -20.06074 31.59052  1.000 31.58907 ? 3   PHE A CZ   1 
ATOM   32   H H    . PHE A 1 3   ? -2.92706  -18.92687 32.41661  1.000 35.93989 ? 3   PHE A H    1 
ATOM   33   H HA   . PHE A 1 3   ? -5.03568  -20.60346 32.27783  1.000 41.32454 ? 3   PHE A HA   1 
ATOM   34   H HB2  . PHE A 1 3   ? -5.65279  -18.31946 33.10202  1.000 37.24175 ? 3   PHE A HB2  1 
ATOM   35   H HB3  . PHE A 1 3   ? -5.55655  -17.93543 31.56229  1.000 37.24175 ? 3   PHE A HB3  1 
ATOM   36   H HD1  . PHE A 1 3   ? -7.16832  -20.37496 33.57122  1.000 35.80822 ? 3   PHE A HD1  1 
ATOM   37   H HD2  . PHE A 1 3   ? -7.48396  -18.10418 30.28351  1.000 36.04538 ? 3   PHE A HD2  1 
ATOM   38   H HE1  . PHE A 1 3   ? -9.33364  -21.10151 33.29201  1.000 43.84787 ? 3   PHE A HE1  1 
ATOM   39   H HE2  . PHE A 1 3   ? -9.65627  -18.83973 29.99129  1.000 41.37569 ? 3   PHE A HE2  1 
ATOM   40   H HZ   . PHE A 1 3   ? -10.54856 -20.38234 31.45202  1.000 37.90689 ? 3   PHE A HZ   1 
ATOM   41   N N    . ARG A 1 4   ? -4.60752  -21.02369 29.95472  1.000 33.78240 ? 4   ARG A N    1 
ATOM   42   C CA   . ARG A 1 4   ? -4.29580  -21.32360 28.58365  1.000 29.74546 ? 4   ARG A CA   1 
ATOM   43   C C    . ARG A 1 4   ? -5.57620  -21.76318 27.88492  1.000 21.12965 ? 4   ARG A C    1 
ATOM   44   O O    . ARG A 1 4   ? -6.47197  -22.32928 28.50626  1.000 21.71042 ? 4   ARG A O    1 
ATOM   45   C CB   . ARG A 1 4   ? -3.22990  -22.43071 28.52834  1.000 25.33923 ? 4   ARG A CB   1 
ATOM   46   C CG   . ARG A 1 4   ? -1.84341  -21.86572 28.70118  1.000 28.22604 ? 4   ARG A CG   1 
ATOM   47   C CD   . ARG A 1 4   ? -1.37244  -21.24954 27.40372  1.000 25.54527 ? 4   ARG A CD   1 
ATOM   48   N NE   . ARG A 1 4   ? 0.07846   -21.11138 27.39532  1.000 29.72866 ? 4   ARG A NE   1 
ATOM   49   C CZ   . ARG A 1 4   ? 0.76539   -20.58722 26.39489  1.000 41.71806 ? 4   ARG A CZ   1 
ATOM   50   N NH1  . ARG A 1 4   ? 0.18557   -20.29296 25.23386  1.000 32.87090 ? 4   ARG A NH1  1 
ATOM   51   N NH2  . ARG A 1 4   ? 2.05609   -20.28731 26.58553  1.000 37.28543 ? 4   ARG A NH2  1 
ATOM   52   H H    . ARG A 1 4   ? -4.98015  -21.67824 30.36919  1.000 40.53888 ? 4   ARG A H    1 
ATOM   53   H HA   . ARG A 1 4   ? -3.95025  -20.54903 28.11325  1.000 35.69455 ? 4   ARG A HA   1 
ATOM   54   H HB2  . ARG A 1 4   ? -3.39264  -23.06928 29.23989  1.000 30.40708 ? 4   ARG A HB2  1 
ATOM   55   H HB3  . ARG A 1 4   ? -3.27424  -22.87622 27.66705  1.000 30.40708 ? 4   ARG A HB3  1 
ATOM   56   H HG2  . ARG A 1 4   ? -1.85220  -21.17914 29.38660  1.000 33.87125 ? 4   ARG A HG2  1 
ATOM   57   H HG3  . ARG A 1 4   ? -1.22893  -22.57438 28.94996  1.000 33.87125 ? 4   ARG A HG3  1 
ATOM   58   H HD2  . ARG A 1 4   ? -1.63272  -21.81729 26.66228  1.000 30.65433 ? 4   ARG A HD2  1 
ATOM   59   H HD3  . ARG A 1 4   ? -1.76710  -20.36879 27.30113  1.000 30.65433 ? 4   ARG A HD3  1 
ATOM   60   H HE   . ARG A 1 4   ? 0.51443   -21.38846 28.08330  1.000 35.67439 ? 4   ARG A HE   1 
ATOM   61   H HH11 . ARG A 1 4   ? -0.65427  -20.44356 25.12247  1.000 39.44509 ? 4   ARG A HH11 1 
ATOM   62   H HH12 . ARG A 1 4   ? 0.64952   -19.95220 24.59524  1.000 39.44509 ? 4   ARG A HH12 1 
ATOM   63   H HH21 . ARG A 1 4   ? 2.42394   -20.43648 27.34857  1.000 44.74252 ? 4   ARG A HH21 1 
ATOM   64   H HH22 . ARG A 1 4   ? 2.51804   -19.94654 25.94490  1.000 44.74252 ? 4   ARG A HH22 1 
ATOM   65   N N    . LYS A 1 5   ? -5.64999  -21.46145 26.59408  1.000 22.29078 ? 5   LYS A N    1 
ATOM   66   C CA   . LYS A 1 5   ? -6.68724  -22.01774 25.72937  1.000 21.82096 ? 5   LYS A CA   1 
ATOM   67   C C    . LYS A 1 5   ? -6.35199  -23.48634 25.50759  1.000 23.11878 ? 5   LYS A C    1 
ATOM   68   O O    . LYS A 1 5   ? -5.47043  -23.84116 24.73068  1.000 31.05873 ? 5   LYS A O    1 
ATOM   69   C CB   . LYS A 1 5   ? -6.78641  -21.23002 24.44083  1.000 27.09210 ? 5   LYS A CB   1 
ATOM   70   C CG   . LYS A 1 5   ? -7.98382  -21.60247 23.62017  1.000 27.30393 ? 5   LYS A CG   1 
ATOM   71   C CD   . LYS A 1 5   ? -8.21225  -20.59700 22.55471  1.000 31.29647 ? 5   LYS A CD   1 
ATOM   72   C CE   . LYS A 1 5   ? -8.49355  -19.25562 23.20844  1.000 34.48541 ? 5   LYS A CE   1 
ATOM   73   N NZ   . LYS A 1 5   ? -9.24186  -18.43562 22.24368  1.000 28.19232 ? 5   LYS A NZ   1 
ATOM   74   H H    . LYS A 1 5   ? -5.10526  -20.93176 26.18960  1.000 26.74893 ? 5   LYS A H    1 
ATOM   75   H HA   . LYS A 1 5   ? -7.55843  -21.96169 26.15210  1.000 26.18515 ? 5   LYS A HA   1 
ATOM   76   H HB2  . LYS A 1 5   ? -6.84923  -20.28620 24.65239  1.000 32.51052 ? 5   LYS A HB2  1 
ATOM   77   H HB3  . LYS A 1 5   ? -5.99309  -21.39807 23.90800  1.000 32.51052 ? 5   LYS A HB3  1 
ATOM   78   H HG2  . LYS A 1 5   ? -7.83799  -22.46710 23.20469  1.000 32.76472 ? 5   LYS A HG2  1 
ATOM   79   H HG3  . LYS A 1 5   ? -8.77000  -21.63645 24.18787  1.000 32.76472 ? 5   LYS A HG3  1 
ATOM   80   H HD2  . LYS A 1 5   ? -7.42311  -20.51803 21.99704  1.000 37.55576 ? 5   LYS A HD2  1 
ATOM   81   H HD3  . LYS A 1 5   ? -8.97585  -20.85327 22.01428  1.000 37.55576 ? 5   LYS A HD3  1 
ATOM   82   H HE2  . LYS A 1 5   ? -9.02873  -19.37754 24.00818  1.000 41.38249 ? 5   LYS A HE2  1 
ATOM   83   H HE3  . LYS A 1 5   ? -7.66198  -18.81010 23.43101  1.000 41.38249 ? 5   LYS A HE3  1 
ATOM   84   H HZ1  . LYS A 1 5   ? -9.39962  -17.62996 22.58712  1.000 33.83079 ? 5   LYS A HZ1  1 
ATOM   85   H HZ2  . LYS A 1 5   ? -8.77167  -18.34379 21.49390  1.000 33.83079 ? 5   LYS A HZ2  1 
ATOM   86   H HZ3  . LYS A 1 5   ? -10.01848 -18.82512 22.05217  1.000 33.83079 ? 5   LYS A HZ3  1 
ATOM   87   N N    . MET A 1 6   ? -7.09052  -24.36033 26.15679  1.000 22.63181 ? 6   MET A N    1 
ATOM   88   C CA   . MET A 1 6   ? -6.68049  -25.74612 26.35108  1.000 21.96937 ? 6   MET A CA   1 
ATOM   89   C C    . MET A 1 6   ? -7.61648  -26.67240 25.59118  1.000 19.00590 ? 6   MET A C    1 
ATOM   90   O O    . MET A 1 6   ? -8.83561  -26.59547 25.76279  1.000 23.63626 ? 6   MET A O    1 
ATOM   91   C CB   . MET A 1 6   ? -6.68674  -26.09104 27.83886  1.000 25.78042 ? 6   MET A CB   1 
ATOM   92   C CG   . MET A 1 6   ? -6.09581  -27.40977 28.16426  1.000 34.76975 ? 6   MET A CG   1 
ATOM   93   S SD   . MET A 1 6   ? -5.36438  -27.42021 29.81051  1.000 39.12131 ? 6   MET A SD   1 
ATOM   94   C CE   . MET A 1 6   ? -5.21392  -25.70439 30.30962  1.000 34.45748 ? 6   MET A CE   1 
ATOM   95   H H    . MET A 1 6   ? -7.85479  -24.17615 26.50563  1.000 27.15817 ? 6   MET A H    1 
ATOM   96   H HA   . MET A 1 6   ? -5.78227  -25.87019 26.00632  1.000 26.36325 ? 6   MET A HA   1 
ATOM   97   H HB2  . MET A 1 6   ? -6.17744  -25.41693 28.31446  1.000 30.93650 ? 6   MET A HB2  1 
ATOM   98   H HB3  . MET A 1 6   ? -7.60485  -26.09597 28.15154  1.000 30.93650 ? 6   MET A HB3  1 
ATOM   99   H HG2  . MET A 1 6   ? -6.78926  -28.08731 28.13360  1.000 41.72370 ? 6   MET A HG2  1 
ATOM   100  H HG3  . MET A 1 6   ? -5.40141  -27.61782 27.52038  1.000 41.72370 ? 6   MET A HG3  1 
ATOM   101  H HE1  . MET A 1 6   ? -4.79626  -25.66560 31.18479  1.000 41.34898 ? 6   MET A HE1  1 
ATOM   102  H HE2  . MET A 1 6   ? -4.66807  -25.23356 29.66111  1.000 41.34898 ? 6   MET A HE2  1 
ATOM   103  H HE3  . MET A 1 6   ? -6.09825  -25.30712 30.34756  1.000 41.34898 ? 6   MET A HE3  1 
ATOM   104  N N    . ALA A 1 7   ? -7.05449  -27.54443 24.75284  1.000 16.33382 ? 7   ALA A N    1 
ATOM   105  C CA   . ALA A 1 7   ? -7.89147  -28.53269 24.09093  1.000 17.87319 ? 7   ALA A CA   1 
ATOM   106  C C    . ALA A 1 7   ? -8.00278  -29.78632 24.95712  1.000 20.91083 ? 7   ALA A C    1 
ATOM   107  O O    . ALA A 1 7   ? -7.21493  -30.01326 25.88726  1.000 22.12893 ? 7   ALA A O    1 
ATOM   108  C CB   . ALA A 1 7   ? -7.32270  -28.90140 22.72691  1.000 21.39686 ? 7   ALA A CB   1 
ATOM   109  H H    . ALA A 1 7   ? -6.21740  -27.57965 24.56011  1.000 19.60058 ? 7   ALA A H    1 
ATOM   110  H HA   . ALA A 1 7   ? -8.77772  -28.16231 23.95485  1.000 21.44783 ? 7   ALA A HA   1 
ATOM   111  H HB1  . ALA A 1 7   ? -7.89602  -29.56560 22.31429  1.000 25.67623 ? 7   ALA A HB1  1 
ATOM   112  H HB2  . ALA A 1 7   ? -7.28714  -28.10503 22.17341  1.000 25.67623 ? 7   ALA A HB2  1 
ATOM   113  H HB3  . ALA A 1 7   ? -6.42945  -29.26176 22.84500  1.000 25.67623 ? 7   ALA A HB3  1 
ATOM   114  N N    . PHE A 1 8   ? -8.99103  -30.59991 24.64927  1.000 17.64927 ? 8   PHE A N    1 
ATOM   115  C CA   . PHE A 1 8   ? -9.05719  -31.91234 25.25044  1.000 16.18085 ? 8   PHE A CA   1 
ATOM   116  C C    . PHE A 1 8   ? -7.99025  -32.83213 24.66825  1.000 19.29007 ? 8   PHE A C    1 
ATOM   117  O O    . PHE A 1 8   ? -7.58096  -32.68308 23.49548  1.000 16.24146 ? 8   PHE A O    1 
ATOM   118  C CB   . PHE A 1 8   ? -10.41562 -32.53829 25.04657  1.000 17.70902 ? 8   PHE A CB   1 
ATOM   119  C CG   . PHE A 1 8   ? -11.50042 -31.86762 25.79160  1.000 19.24428 ? 8   PHE A CG   1 
ATOM   120  C CD1  . PHE A 1 8   ? -11.66171 -32.09858 27.14040  1.000 25.77364 ? 8   PHE A CD1  1 
ATOM   121  C CD2  . PHE A 1 8   ? -12.36586 -31.02490 25.13782  1.000 24.97040 ? 8   PHE A CD2  1 
ATOM   122  C CE1  . PHE A 1 8   ? -12.69644 -31.49282 27.82341  1.000 31.67686 ? 8   PHE A CE1  1 
ATOM   123  C CE2  . PHE A 1 8   ? -13.39360 -30.40014 25.81484  1.000 29.85218 ? 8   PHE A CE2  1 
ATOM   124  C CZ   . PHE A 1 8   ? -13.56187 -30.64709 27.15163  1.000 30.62275 ? 8   PHE A CZ   1 
ATOM   125  H H    . PHE A 1 8   ? -9.62898  -30.41808 24.10216  1.000 21.17912 ? 8   PHE A H    1 
ATOM   126  H HA   . PHE A 1 8   ? -8.90160  -31.82080 26.20355  1.000 19.41702 ? 8   PHE A HA   1 
ATOM   127  H HB2  . PHE A 1 8   ? -10.63732 -32.49989 24.10252  1.000 21.25083 ? 8   PHE A HB2  1 
ATOM   128  H HB3  . PHE A 1 8   ? -10.38099 -33.46145 25.34202  1.000 21.25083 ? 8   PHE A HB3  1 
ATOM   129  H HD1  . PHE A 1 8   ? -11.07342 -32.66139 27.59026  1.000 30.92837 ? 8   PHE A HD1  1 
ATOM   130  H HD2  . PHE A 1 8   ? -12.25766 -30.87325 24.22695  1.000 29.96448 ? 8   PHE A HD2  1 
ATOM   131  H HE1  . PHE A 1 8   ? -12.81163 -31.65147 28.73227  1.000 38.01223 ? 8   PHE A HE1  1 
ATOM   132  H HE2  . PHE A 1 8   ? -13.96590 -29.81932 25.36800  1.000 35.82261 ? 8   PHE A HE2  1 
ATOM   133  H HZ   . PHE A 1 8   ? -14.26236 -30.24394 27.61063  1.000 36.74730 ? 8   PHE A HZ   1 
ATOM   134  N N    . PRO A 1 9   ? -7.52477  -33.80226 25.47781  1.000 20.23746 ? 9   PRO A N    1 
ATOM   135  C CA   . PRO A 1 9   ? -6.58979  -34.80920 24.97552  1.000 20.45048 ? 9   PRO A CA   1 
ATOM   136  C C    . PRO A 1 9   ? -7.30382  -35.52808 23.84583  1.000 22.21201 ? 9   PRO A C    1 
ATOM   137  O O    . PRO A 1 9   ? -8.50963  -35.79809 23.93323  1.000 22.41724 ? 9   PRO A O    1 
ATOM   138  C CB   . PRO A 1 9   ? -6.32651  -35.70875 26.20106  1.000 24.81052 ? 9   PRO A CB   1 
ATOM   139  C CG   . PRO A 1 9   ? -6.69960  -34.86178 27.38745  1.000 31.94463 ? 9   PRO A CG   1 
ATOM   140  C CD   . PRO A 1 9   ? -7.90904  -34.07341 26.85651  1.000 19.29508 ? 9   PRO A CD   1 
ATOM   141  H HA   . PRO A 1 9   ? -5.73297  -34.45335 24.69304  1.000 24.54058 ? 9   PRO A HA   1 
ATOM   142  H HB2  . PRO A 1 9   ? -6.88086  -36.50316 26.15338  1.000 29.77262 ? 9   PRO A HB2  1 
ATOM   143  H HB3  . PRO A 1 9   ? -5.39032  -35.95803 26.23324  1.000 29.77262 ? 9   PRO A HB3  1 
ATOM   144  H HG2  . PRO A 1 9   ? -6.94142  -35.42044 28.14302  1.000 38.33356 ? 9   PRO A HG2  1 
ATOM   145  H HG3  . PRO A 1 9   ? -5.96815  -34.27335 27.63107  1.000 38.33356 ? 9   PRO A HG3  1 
ATOM   146  H HD2  . PRO A 1 9   ? -8.71763  -34.60808 26.89390  1.000 23.15410 ? 9   PRO A HD2  1 
ATOM   147  H HD3  . PRO A 1 9   ? -8.03287  -33.24982 27.35297  1.000 23.15410 ? 9   PRO A HD3  1 
ATOM   148  N N    . SER A 1 10  ? -6.58026  -35.74483 22.76095  1.000 18.95164 ? 10  SER A N    1 
ATOM   149  C CA   . SER A 1 10  ? -7.16351  -36.12651 21.47851  1.000 14.47912 ? 10  SER A CA   1 
ATOM   150  C C    . SER A 1 10  ? -7.06122  -37.62726 21.20862  1.000 16.02780 ? 10  SER A C    1 
ATOM   151  O O    . SER A 1 10  ? -7.56148  -38.09103 20.18615  1.000 19.38421 ? 10  SER A O    1 
ATOM   152  C CB   . SER A 1 10  ? -6.49371  -35.36227 20.33921  1.000 21.93332 ? 10  SER A CB   1 
ATOM   153  O OG   . SER A 1 10  ? -5.09850  -35.57108 20.21158  1.000 19.99407 ? 10  SER A OG   1 
ATOM   154  H H    . SER A 1 10  ? -5.72331  -35.67614 22.73729  1.000 22.74197 ? 10  SER A H    1 
ATOM   155  H HA   . SER A 1 10  ? -8.10270  -35.88226 21.48533  1.000 17.37495 ? 10  SER A HA   1 
ATOM   156  H HB2  . SER A 1 10  ? -6.91420  -35.63709 19.50890  1.000 26.31998 ? 10  SER A HB2  1 
ATOM   157  H HB3  . SER A 1 10  ? -6.64152  -34.41548 20.48875  1.000 26.31998 ? 10  SER A HB3  1 
ATOM   158  H HG   . SER A 1 10  ? -4.88121  -35.57241 19.39965  1.000 23.99288 ? 10  SER A HG   1 
ATOM   159  N N    . GLY A 1 11  ? -6.40493  -38.38929 22.10638  1.000 20.92800 ? 11  GLY A N    1 
ATOM   160  C CA   . GLY A 1 11  ? -6.13572  -39.78290 21.82161  1.000 18.86643 ? 11  GLY A CA   1 
ATOM   161  C C    . GLY A 1 11  ? -7.38698  -40.53966 21.43171  1.000 19.43252 ? 11  GLY A C    1 
ATOM   162  O O    . GLY A 1 11  ? -7.41906  -41.23305 20.40327  1.000 28.11982 ? 11  GLY A O    1 
ATOM   163  H H    . GLY A 1 11  ? -6.11541  -38.11653 22.86865  1.000 25.11360 ? 11  GLY A H    1 
ATOM   164  H HA2  . GLY A 1 11  ? -5.50041  -39.84495 21.09180  1.000 22.63972 ? 11  GLY A HA2  1 
ATOM   165  H HA3  . GLY A 1 11  ? -5.75566  -40.20408 22.60849  1.000 22.63972 ? 11  GLY A HA3  1 
ATOM   166  N N    . LYS A 1 12  ? -8.45838  -40.37799 22.20743  1.000 19.42002 ? 12  LYS A N    1 
ATOM   167  C CA   . LYS A 1 12  ? -9.65367  -41.16178 21.95152  1.000 23.96932 ? 12  LYS A CA   1 
ATOM   168  C C    . LYS A 1 12  ? -10.18337 -40.91134 20.55149  1.000 28.48176 ? 12  LYS A C    1 
ATOM   169  O O    . LYS A 1 12  ? -10.77144 -41.81644 19.94572  1.000 26.26039 ? 12  LYS A O    1 
ATOM   170  C CB   . LYS A 1 12  ? -10.72930 -40.82627 22.98035  1.000 20.28003 ? 12  LYS A CB   1 
ATOM   171  C CG   . LYS A 1 12  ? -10.40236 -41.35586 24.35214  1.000 29.53758 ? 12  LYS A CG   1 
ATOM   172  C CD   . LYS A 1 12  ? -11.43310 -40.87330 25.36607  1.000 32.32687 ? 12  LYS A CD   1 
ATOM   173  C CE   . LYS A 1 12  ? -10.97835 -41.19182 26.78204  1.000 41.47545 ? 12  LYS A CE   1 
ATOM   174  N NZ   . LYS A 1 12  ? -11.42937 -42.56938 27.12003  1.000 38.22326 ? 12  LYS A NZ   1 
ATOM   175  H H    . LYS A 1 12  ? -8.51305  -39.83344 22.86974  1.000 23.30402 ? 12  LYS A H    1 
ATOM   176  H HA   . LYS A 1 12  ? -9.43695  -42.10266 22.03702  1.000 28.76319 ? 12  LYS A HA   1 
ATOM   177  H HB2  . LYS A 1 12  ? -10.81709 -39.86238 23.04291  1.000 24.33604 ? 12  LYS A HB2  1 
ATOM   178  H HB3  . LYS A 1 12  ? -11.56988 -41.21877 22.69781  1.000 24.33604 ? 12  LYS A HB3  1 
ATOM   179  H HG2  . LYS A 1 12  ? -10.41258 -42.32586 24.33754  1.000 35.44510 ? 12  LYS A HG2  1 
ATOM   180  H HG3  . LYS A 1 12  ? -9.52771  -41.03733 24.62364  1.000 35.44510 ? 12  LYS A HG3  1 
ATOM   181  H HD2  . LYS A 1 12  ? -11.54284 -39.91334 25.28463  1.000 38.79224 ? 12  LYS A HD2  1 
ATOM   182  H HD3  . LYS A 1 12  ? -12.27969 -41.31988 25.20550  1.000 38.79224 ? 12  LYS A HD3  1 
ATOM   183  H HE2  . LYS A 1 12  ? -10.01040 -41.15108 26.83840  1.000 49.77053 ? 12  LYS A HE2  1 
ATOM   184  H HE3  . LYS A 1 12  ? -11.37307 -40.56451 27.40729  1.000 49.77053 ? 12  LYS A HE3  1 
ATOM   185  H HZ1  . LYS A 1 12  ? -11.19551 -42.76971 27.95499  1.000 45.86791 ? 12  LYS A HZ1  1 
ATOM   186  H HZ2  . LYS A 1 12  ? -12.31430 -42.62604 27.04568  1.000 45.86791 ? 12  LYS A HZ2  1 
ATOM   187  H HZ3  . LYS A 1 12  ? -11.05571 -43.15674 26.56580  1.000 45.86791 ? 12  LYS A HZ3  1 
ATOM   188  N N    . VAL A 1 13  ? -9.97714  -39.70285 20.02131  1.000 21.71472 ? 13  VAL A N    1 
ATOM   189  C CA   . VAL A 1 13  ? -10.49397 -39.33745 18.70435  1.000 20.27505 ? 13  VAL A CA   1 
ATOM   190  C C    . VAL A 1 13  ? -9.50226  -39.76101 17.65044  1.000 18.25230 ? 13  VAL A C    1 
ATOM   191  O O    . VAL A 1 13  ? -9.89752  -40.20966 16.56102  1.000 18.56194 ? 13  VAL A O    1 
ATOM   192  C CB   . VAL A 1 13  ? -10.77615 -37.82964 18.65018  1.000 18.96141 ? 13  VAL A CB   1 
ATOM   193  C CG1  . VAL A 1 13  ? -11.20397 -37.42710 17.21728  1.000 18.99522 ? 13  VAL A CG1  1 
ATOM   194  C CG2  . VAL A 1 13  ? -11.84578 -37.47010 19.63203  1.000 22.66445 ? 13  VAL A CG2  1 
ATOM   195  H H    . VAL A 1 13  ? -9.53878  -39.07274 20.40885  1.000 26.05766 ? 13  VAL A H    1 
ATOM   196  H HA   . VAL A 1 13  ? -11.33855 -39.78202 18.52978  1.000 24.33006 ? 13  VAL A HA   1 
ATOM   197  H HB   . VAL A 1 13  ? -9.97162  -37.34114 18.88277  1.000 22.75370 ? 13  VAL A HB   1 
ATOM   198  H HG11 . VAL A 1 13  ? -11.52070 -36.51036 17.22773  1.000 22.79426 ? 13  VAL A HG11 1 
ATOM   199  H HG12 . VAL A 1 13  ? -10.43969 -37.50613 16.62550  1.000 22.79426 ? 13  VAL A HG12 1 
ATOM   200  H HG13 . VAL A 1 13  ? -11.91339 -38.01848 16.92066  1.000 22.79426 ? 13  VAL A HG13 1 
ATOM   201  H HG21 . VAL A 1 13  ? -12.12845 -36.55722 19.47149  1.000 27.19733 ? 13  VAL A HG21 1 
ATOM   202  H HG22 . VAL A 1 13  ? -12.59626 -38.07462 19.51739  1.000 27.19733 ? 13  VAL A HG22 1 
ATOM   203  H HG23 . VAL A 1 13  ? -11.48904 -37.55337 20.53110  1.000 27.19733 ? 13  VAL A HG23 1 
ATOM   204  N N    . GLU A 1 14  ? -8.21142  -39.70719 17.97793  1.000 19.81574 ? 14  GLU A N    1 
ATOM   205  C CA   . GLU A 1 14  ? -7.20175  -40.11778 17.00703  1.000 21.05163 ? 14  GLU A CA   1 
ATOM   206  C C    . GLU A 1 14  ? -7.46845  -41.53269 16.51706  1.000 24.18115 ? 14  GLU A C    1 
ATOM   207  O O    . GLU A 1 14  ? -7.26778  -41.84181 15.33294  1.000 25.21015 ? 14  GLU A O    1 
ATOM   208  C CB   . GLU A 1 14  ? -5.79902  -40.04604 17.61457  1.000 24.51985 ? 14  GLU A CB   1 
ATOM   209  C CG   . GLU A 1 14  ? -5.17718  -38.64163 17.74466  1.000 22.12940 ? 14  GLU A CG   1 
ATOM   210  C CD   . GLU A 1 14  ? -3.91149  -38.64816 18.62010  1.000 20.63320 ? 14  GLU A CD   1 
ATOM   211  O OE1  . GLU A 1 14  ? -2.99974  -39.46827 18.35491  1.000 27.18826 ? 14  GLU A OE1  1 
ATOM   212  O OE2  . GLU A 1 14  ? -3.88344  -37.88173 19.59058  1.000 22.70716 ? 14  GLU A OE2  1 
ATOM   213  H H    . GLU A 1 14  ? -7.90290  -39.44241 18.73620  1.000 23.77888 ? 14  GLU A H    1 
ATOM   214  H HA   . GLU A 1 14  ? -7.23697  -39.50435 16.25640  1.000 25.26196 ? 14  GLU A HA   1 
ATOM   215  H HB2  . GLU A 1 14  ? -5.83803  -40.42362 18.50732  1.000 29.42382 ? 14  GLU A HB2  1 
ATOM   216  H HB3  . GLU A 1 14  ? -5.20241  -40.57022 17.05846  1.000 29.42382 ? 14  GLU A HB3  1 
ATOM   217  H HG2  . GLU A 1 14  ? -4.93413  -38.31789 16.86394  1.000 26.55528 ? 14  GLU A HG2  1 
ATOM   218  H HG3  . GLU A 1 14  ? -5.82380  -38.04339 18.15180  1.000 26.55528 ? 14  GLU A HG3  1 
ATOM   219  N N    . GLY A 1 15  ? -7.94007  -42.40663 17.42036  1.000 23.06955 ? 15  GLY A N    1 
ATOM   220  C CA   . GLY A 1 15  ? -8.15784  -43.79458 17.06343  1.000 31.44323 ? 15  GLY A CA   1 
ATOM   221  C C    . GLY A 1 15  ? -9.32234  -44.01493 16.12488  1.000 28.53350 ? 15  GLY A C    1 
ATOM   222  O O    . GLY A 1 15  ? -9.45827  -45.11170 15.57815  1.000 26.88810 ? 15  GLY A O    1 
ATOM   223  H H    . GLY A 1 15  ? -8.13552  -42.21229 18.23541  1.000 27.68346 ? 15  GLY A H    1 
ATOM   224  H HA2  . GLY A 1 15  ? -7.35942  -44.13668 16.63250  1.000 37.73188 ? 15  GLY A HA2  1 
ATOM   225  H HA3  . GLY A 1 15  ? -8.32472  -44.30421 17.87105  1.000 37.73188 ? 15  GLY A HA3  1 
ATOM   226  N N    . CYS A 1 16  ? -10.15409 -42.98547 15.93022  1.000 25.39035 ? 16  CYS A N    1 
ATOM   227  C CA   . CYS A 1 16  ? -11.31170 -43.08285 15.04775  1.000 23.32540 ? 16  CYS A CA   1 
ATOM   228  C C    . CYS A 1 16  ? -11.15076 -42.41389 13.70622  1.000 23.57095 ? 16  CYS A C    1 
ATOM   229  O O    . CYS A 1 16  ? -12.10144 -42.45216 12.90986  1.000 24.20224 ? 16  CYS A O    1 
ATOM   230  C CB   . CYS A 1 16  ? -12.58437 -42.52626 15.69365  1.000 18.95527 ? 16  CYS A CB   1 
ATOM   231  S SG   . CYS A 1 16  ? -12.89553 -43.06754 17.35920  1.000 29.13428 ? 16  CYS A SG   1 
ATOM   232  H H    . CYS A 1 16  ? -10.06283 -42.21563 16.30273  1.000 30.46842 ? 16  CYS A H    1 
ATOM   233  H HA   . CYS A 1 16  ? -11.43089 -44.03486 14.90212  1.000 27.99048 ? 16  CYS A HA   1 
ATOM   234  H HB2  . CYS A 1 16  ? -12.51915 -41.55822 15.71227  1.000 22.74633 ? 16  CYS A HB2  1 
ATOM   235  H HB3  . CYS A 1 16  ? -13.34396 -42.79753 15.15521  1.000 22.74633 ? 16  CYS A HB3  1 
ATOM   236  H HG   . CYS A 1 16  ? -13.85114 -42.48256 17.78823  1.000 34.96114 ? 16  CYS A HG   1 
ATOM   237  N N    . MET A 1 17  ? -9.99710  -41.84679 13.40098  1.000 20.34566 ? 17  MET A N    1 
ATOM   238  C CA   . MET A 1 17  ? -9.86027  -41.08992 12.17749  1.000 18.87677 ? 17  MET A CA   1 
ATOM   239  C C    . MET A 1 17  ? -9.40613  -42.02588 11.06407  1.000 26.51455 ? 17  MET A C    1 
ATOM   240  O O    . MET A 1 17  ? -8.49855  -42.84028 11.26389  1.000 22.41078 ? 17  MET A O    1 
ATOM   241  C CB   . MET A 1 17  ? -8.84123  -39.95722 12.34455  1.000 23.73527 ? 17  MET A CB   1 
ATOM   242  C CG   . MET A 1 17  ? -9.24744  -38.86614 13.31608  1.000 23.68501 ? 17  MET A CG   1 
ATOM   243  S SD   . MET A 1 17  ? -10.94485 -38.26436 13.11285  1.000 23.51233 ? 17  MET A SD   1 
ATOM   244  C CE   . MET A 1 17  ? -10.94067 -37.72831 11.40518  1.000 28.62089 ? 17  MET A CE   1 
ATOM   245  H H    . MET A 1 17  ? -9.28724  -41.88752 13.88420  1.000 24.41479 ? 17  MET A H    1 
ATOM   246  H HA   . MET A 1 17  ? -10.71451 -40.69047 11.95144  1.000 22.65213 ? 17  MET A HA   1 
ATOM   247  H HB2  . MET A 1 17  ? -8.00904  -40.33775 12.66561  1.000 28.48232 ? 17  MET A HB2  1 
ATOM   248  H HB3  . MET A 1 17  ? -8.70226  -39.53957 11.47986  1.000 28.48232 ? 17  MET A HB3  1 
ATOM   249  H HG2  . MET A 1 17  ? -9.16548  -39.21163 14.21890  1.000 28.42202 ? 17  MET A HG2  1 
ATOM   250  H HG3  . MET A 1 17  ? -8.65300  -38.10859 13.19676  1.000 28.42202 ? 17  MET A HG3  1 
ATOM   251  H HE1  . MET A 1 17  ? -11.81986 -37.38787 11.17908  1.000 34.34507 ? 17  MET A HE1  1 
ATOM   252  H HE2  . MET A 1 17  ? -10.27719 -37.02871 11.29585  1.000 34.34507 ? 17  MET A HE2  1 
ATOM   253  H HE3  . MET A 1 17  ? -10.72187 -38.48378 10.83779  1.000 34.34507 ? 17  MET A HE3  1 
ATOM   254  N N    . VAL A 1 18  ? -10.05580 -41.92068 9.89891   1.000 18.83029 ? 18  VAL A N    1 
ATOM   255  C CA   . VAL A 1 18  ? -9.70276  -42.71167 8.72655   1.000 28.57388 ? 18  VAL A CA   1 
ATOM   256  C C    . VAL A 1 18  ? -9.71004  -41.80692 7.49010   1.000 24.72522 ? 18  VAL A C    1 
ATOM   257  O O    . VAL A 1 18  ? -10.23193 -40.69233 7.49560   1.000 21.64531 ? 18  VAL A O    1 
ATOM   258  C CB   . VAL A 1 18  ? -10.65373 -43.91931 8.53147   1.000 20.32798 ? 18  VAL A CB   1 
ATOM   259  C CG1  . VAL A 1 18  ? -10.62442 -44.85504 9.75690   1.000 32.39931 ? 18  VAL A CG1  1 
ATOM   260  C CG2  . VAL A 1 18  ? -12.04701 -43.43924 8.23627   1.000 24.06670 ? 18  VAL A CG2  1 
ATOM   261  H H    . VAL A 1 18  ? -10.71618 -41.38612 9.76601   1.000 22.59635 ? 18  VAL A H    1 
ATOM   262  H HA   . VAL A 1 18  ? -8.80053  -43.05002 8.83266   1.000 34.28866 ? 18  VAL A HA   1 
ATOM   263  H HB   . VAL A 1 18  ? -10.34804 -44.44060 7.77225   1.000 24.39357 ? 18  VAL A HB   1 
ATOM   264  H HG11 . VAL A 1 18  ? -11.17874 -45.63037 9.57523   1.000 38.87917 ? 18  VAL A HG11 1 
ATOM   265  H HG12 . VAL A 1 18  ? -9.71025  -45.13342 9.92005   1.000 38.87917 ? 18  VAL A HG12 1 
ATOM   266  H HG13 . VAL A 1 18  ? -10.96707 -44.37679 10.52807  1.000 38.87917 ? 18  VAL A HG13 1 
ATOM   267  H HG21 . VAL A 1 18  ? -12.63437 -44.20665 8.15359   1.000 28.88004 ? 18  VAL A HG21 1 
ATOM   268  H HG22 . VAL A 1 18  ? -12.34672 -42.87092 8.96252   1.000 28.88004 ? 18  VAL A HG22 1 
ATOM   269  H HG23 . VAL A 1 18  ? -12.03911 -42.93772 7.40558   1.000 28.88004 ? 18  VAL A HG23 1 
ATOM   270  N N    . GLN A 1 19  ? -9.09326  -42.31177 6.43001   1.000 28.67378 ? 19  GLN A N    1 
ATOM   271  C CA   . GLN A 1 19  ? -9.10729  -41.69597 5.11838   1.000 27.04038 ? 19  GLN A CA   1 
ATOM   272  C C    . GLN A 1 19  ? -10.23253 -42.28336 4.28862   1.000 23.92755 ? 19  GLN A C    1 
ATOM   273  O O    . GLN A 1 19  ? -10.42455 -43.50250 4.26480   1.000 26.98166 ? 19  GLN A O    1 
ATOM   274  C CB   . GLN A 1 19  ? -7.76785  -41.95749 4.44669   1.000 33.10626 ? 19  GLN A CB   1 
ATOM   275  C CG   . GLN A 1 19  ? -7.53988  -41.32949 3.11916   1.000 37.87879 ? 19  GLN A CG   1 
ATOM   276  C CD   . GLN A 1 19  ? -6.35612  -41.97413 2.43418   1.000 36.91837 ? 19  GLN A CD   1 
ATOM   277  O OE1  . GLN A 1 19  ? -6.43905  -43.13094 2.01144   1.000 48.40372 ? 19  GLN A OE1  1 
ATOM   278  N NE2  . GLN A 1 19  ? -5.24466  -41.25719 2.34702   1.000 45.70432 ? 19  GLN A NE2  1 
ATOM   279  H H    . GLN A 1 19  ? -8.64169  -43.04342 6.44872   1.000 34.40853 ? 19  GLN A H    1 
ATOM   280  H HA   . GLN A 1 19  ? -9.25708  -40.74014 5.18892   1.000 32.44845 ? 19  GLN A HA   1 
ATOM   281  H HB2  . GLN A 1 19  ? -7.07031  -41.63130 5.03614   1.000 39.72751 ? 19  GLN A HB2  1 
ATOM   282  H HB3  . GLN A 1 19  ? -7.67804  -42.91535 4.32413   1.000 39.72751 ? 19  GLN A HB3  1 
ATOM   283  H HG2  . GLN A 1 19  ? -8.32458  -41.45078 2.56181   1.000 45.45454 ? 19  GLN A HG2  1 
ATOM   284  H HG3  . GLN A 1 19  ? -7.35667  -40.38442 3.23281   1.000 45.45454 ? 19  GLN A HG3  1 
ATOM   285  H HE21 . GLN A 1 19  ? -5.21941  -40.46137 2.67351   1.000 54.84518 ? 19  GLN A HE21 1 
ATOM   286  H HE22 . GLN A 1 19  ? -4.54826  -41.58740 1.96506   1.000 54.84518 ? 19  GLN A HE22 1 
ATOM   287  N N    . VAL A 1 20  ? -10.97698 -41.42053 3.60489   1.000 23.91524 ? 20  VAL A N    1 
ATOM   288  C CA   . VAL A 1 20  ? -12.04231 -41.87083 2.71924   1.000 26.10873 ? 20  VAL A CA   1 
ATOM   289  C C    . VAL A 1 20  ? -11.77426 -41.30976 1.32768   1.000 23.81587 ? 20  VAL A C    1 
ATOM   290  O O    . VAL A 1 20  ? -11.62817 -40.09054 1.16248   1.000 28.28918 ? 20  VAL A O    1 
ATOM   291  C CB   . VAL A 1 20  ? -13.44082 -41.43824 3.19401   1.000 22.79317 ? 20  VAL A CB   1 
ATOM   292  C CG1  . VAL A 1 20  ? -14.45811 -41.84538 2.11440   1.000 22.57591 ? 20  VAL A CG1  1 
ATOM   293  C CG2  . VAL A 1 20  ? -13.80781 -42.04536 4.54251   1.000 26.07215 ? 20  VAL A CG2  1 
ATOM   294  H H    . VAL A 1 20  ? -10.88267 -40.56648 3.63945   1.000 28.69828 ? 20  VAL A H    1 
ATOM   295  H HA   . VAL A 1 20  ? -12.01852 -42.83980 2.69065   1.000 31.33048 ? 20  VAL A HA   1 
ATOM   296  H HB   . VAL A 1 20  ? -13.45263 -40.47733 3.32360   1.000 27.35181 ? 20  VAL A HB   1 
ATOM   297  H HG11 . VAL A 1 20  ? -15.33419 -41.93233 2.52204   1.000 27.09110 ? 20  VAL A HG11 1 
ATOM   298  H HG12 . VAL A 1 20  ? -14.48041 -41.16198 1.42681   1.000 27.09110 ? 20  VAL A HG12 1 
ATOM   299  H HG13 . VAL A 1 20  ? -14.18830 -42.69393 1.72897   1.000 27.09110 ? 20  VAL A HG13 1 
ATOM   300  H HG21 . VAL A 1 20  ? -14.68715 -41.72922 4.80139   1.000 31.28658 ? 20  VAL A HG21 1 
ATOM   301  H HG22 . VAL A 1 20  ? -13.81301 -43.01132 4.46291   1.000 31.28658 ? 20  VAL A HG22 1 
ATOM   302  H HG23 . VAL A 1 20  ? -13.15026 -41.77125 5.20191   1.000 31.28658 ? 20  VAL A HG23 1 
ATOM   303  N N    . THR A 1 21  ? -11.76320 -42.19213 0.32314   1.000 28.95608 ? 21  THR A N    1 
ATOM   304  C CA   . THR A 1 21  ? -11.50800 -41.82707 -1.06955  1.000 31.98665 ? 21  THR A CA   1 
ATOM   305  C C    . THR A 1 21  ? -12.66331 -42.31346 -1.93526  1.000 31.18395 ? 21  THR A C    1 
ATOM   306  O O    . THR A 1 21  ? -13.20251 -43.40902 -1.73012  1.000 28.16038 ? 21  THR A O    1 
ATOM   307  C CB   . THR A 1 21  ? -10.17136 -42.42171 -1.55144  1.000 37.10096 ? 21  THR A CB   1 
ATOM   308  O OG1  . THR A 1 21  ? -9.10406  -41.88335 -0.76073  1.000 35.26878 ? 21  THR A OG1  1 
ATOM   309  C CG2  . THR A 1 21  ? -9.87512  -42.06857 -3.01312  1.000 37.51409 ? 21  THR A CG2  1 
ATOM   310  H H    . THR A 1 21  ? -11.90557 -43.03431 0.43057   1.000 34.74730 ? 21  THR A H    1 
ATOM   311  H HA   . THR A 1 21  ? -11.45274 -40.86297 -1.16393  1.000 38.38398 ? 21  THR A HA   1 
ATOM   312  H HB   . THR A 1 21  ? -10.22762 -43.38681 -1.47006  1.000 44.52115 ? 21  THR A HB   1 
ATOM   313  H HG1  . THR A 1 21  ? -9.05869  -41.05125 -0.86820  1.000 42.32253 ? 21  THR A HG1  1 
ATOM   314  H HG21 . THR A 1 21  ? -8.94690  -42.25971 -3.21891  1.000 45.01691 ? 21  THR A HG21 1 
ATOM   315  H HG22 . THR A 1 21  ? -10.44250 -42.59066 -3.60264  1.000 45.01691 ? 21  THR A HG22 1 
ATOM   316  H HG23 . THR A 1 21  ? -10.04482 -41.12561 -3.16760  1.000 45.01691 ? 21  THR A HG23 1 
ATOM   317  N N    . CYS A 1 22  ? -13.05665 -41.47019 -2.87187  1.000 30.11808 ? 22  CYS A N    1 
ATOM   318  C CA   . CYS A 1 22  ? -14.15411 -41.74551 -3.77343  1.000 27.65471 ? 22  CYS A CA   1 
ATOM   319  C C    . CYS A 1 22  ? -13.74925 -41.01041 -5.04084  1.000 40.63276 ? 22  CYS A C    1 
ATOM   320  O O    . CYS A 1 22  ? -13.51723 -39.79425 -4.99200  1.000 41.96089 ? 22  CYS A O    1 
ATOM   321  C CB   . CYS A 1 22  ? -15.48072 -41.23491 -3.21558  1.000 26.16273 ? 22  CYS A CB   1 
ATOM   322  S SG   . CYS A 1 22  ? -16.88493 -41.77442 -4.21141  1.000 38.23590 ? 22  CYS A SG   1 
ATOM   323  H H    . CYS A 1 22  ? -12.68921 -40.70382 -3.01027  1.000 36.14170 ? 22  CYS A H    1 
ATOM   324  H HA   . CYS A 1 22  ? -14.28730 -42.69152 -3.93606  1.000 33.18565 ? 22  CYS A HA   1 
ATOM   325  H HB2  . CYS A 1 22  ? -15.59876 -41.57456 -2.31484  1.000 31.39528 ? 22  CYS A HB2  1 
ATOM   326  H HB3  . CYS A 1 22  ? -15.47049 -40.26491 -3.20598  1.000 31.39528 ? 22  CYS A HB3  1 
ATOM   327  H HG   . CYS A 1 22  ? -17.89047 -41.30850 -3.75248  1.000 45.88308 ? 22  CYS A HG   1 
ATOM   328  N N    . GLY A 1 23  ? -13.58628 -41.74160 -6.14723  1.000 42.73624 ? 23  GLY A N    1 
ATOM   329  C CA   . GLY A 1 23  ? -12.94133 -41.15637 -7.30964  1.000 38.64090 ? 23  GLY A CA   1 
ATOM   330  C C    . GLY A 1 23  ? -11.64200 -40.48857 -6.92677  1.000 41.88898 ? 23  GLY A C    1 
ATOM   331  O O    . GLY A 1 23  ? -10.77374 -41.10127 -6.28284  1.000 45.47891 ? 23  GLY A O    1 
ATOM   332  H H    . GLY A 1 23  ? -13.83659 -42.55874 -6.24282  1.000 51.28348 ? 23  GLY A H    1 
ATOM   333  H HA2  . GLY A 1 23  ? -12.75455 -41.84782 -7.96400  1.000 46.36908 ? 23  GLY A HA2  1 
ATOM   334  H HA3  . GLY A 1 23  ? -13.52572 -40.49359 -7.70944  1.000 46.36908 ? 23  GLY A HA3  1 
ATOM   335  N N    . THR A 1 24  ? -11.49089 -39.20522 -7.28893  1.000 40.88532 ? 24  THR A N    1 
ATOM   336  C CA   . THR A 1 24  ? -10.22553 -38.51138 -7.02805  1.000 40.70200 ? 24  THR A CA   1 
ATOM   337  C C    . THR A 1 24  ? -10.15754 -37.86117 -5.65763  1.000 36.28647 ? 24  THR A C    1 
ATOM   338  O O    . THR A 1 24  ? -9.05892  -37.59360 -5.16307  1.000 44.27847 ? 24  THR A O    1 
ATOM   339  C CB   . THR A 1 24  ? -9.97405  -37.40854 -8.06228  1.000 46.19841 ? 24  THR A CB   1 
ATOM   340  O OG1  . THR A 1 24  ? -11.21242 -36.78231 -8.41333  1.000 55.05879 ? 24  THR A OG1  1 
ATOM   341  C CG2  . THR A 1 24  ? -9.32416  -37.97226 -9.29640  1.000 54.52754 ? 24  THR A CG2  1 
ATOM   342  H H    . THR A 1 24  ? -12.09213 -38.72846 -7.67584  1.000 49.06238 ? 24  THR A H    1 
ATOM   343  H HA   . THR A 1 24  ? -9.52198  -39.17577 -7.10121  1.000 48.84240 ? 24  THR A HA   1 
ATOM   344  H HB   . THR A 1 24  ? -9.37771  -36.74330 -7.68466  1.000 55.43809 ? 24  THR A HB   1 
ATOM   345  H HG1  . THR A 1 24  ? -11.07870 -36.17785 -8.98091  1.000 66.07055 ? 24  THR A HG1  1 
ATOM   346  H HG21 . THR A 1 24  ? -9.16950  -37.26574 -9.94291  1.000 65.43304 ? 24  THR A HG21 1 
ATOM   347  H HG22 . THR A 1 24  ? -8.47392  -38.37973 -9.06635  1.000 65.43304 ? 24  THR A HG22 1 
ATOM   348  H HG23 . THR A 1 24  ? -9.89748  -38.64547 -9.69602  1.000 65.43304 ? 24  THR A HG23 1 
ATOM   349  N N    . THR A 1 25  ? -11.29497 -37.59746 -5.03787  1.000 42.60385 ? 25  THR A N    1 
ATOM   350  C CA   . THR A 1 25  ? -11.33404 -36.78823 -3.82638  1.000 36.02673 ? 25  THR A CA   1 
ATOM   351  C C    . THR A 1 25  ? -11.00280 -37.63173 -2.59878  1.000 27.13637 ? 25  THR A C    1 
ATOM   352  O O    . THR A 1 25  ? -11.51797 -38.74223 -2.44265  1.000 32.30367 ? 25  THR A O    1 
ATOM   353  C CB   . THR A 1 25  ? -12.71659 -36.14641 -3.70847  1.000 38.58196 ? 25  THR A CB   1 
ATOM   354  O OG1  . THR A 1 25  ? -12.96276 -35.32041 -4.86800  1.000 43.59961 ? 25  THR A OG1  1 
ATOM   355  C CG2  . THR A 1 25  ? -12.84214 -35.34603 -2.43496  1.000 37.39412 ? 25  THR A CG2  1 
ATOM   356  H H    . THR A 1 25  ? -12.06565 -37.87691 -5.29731  1.000 51.12462 ? 25  THR A H    1 
ATOM   357  H HA   . THR A 1 25  ? -10.66458 -36.08667 -3.86771  1.000 43.23208 ? 25  THR A HA   1 
ATOM   358  H HB   . THR A 1 25  ? -13.39592 -36.83752 -3.66814  1.000 46.29835 ? 25  THR A HB   1 
ATOM   359  H HG1  . THR A 1 25  ? -13.72076 -34.96353 -4.81164  1.000 52.31954 ? 25  THR A HG1  1 
ATOM   360  H HG21 . THR A 1 25  ? -13.72455 -34.94751 -2.38014  1.000 44.87295 ? 25  THR A HG21 1 
ATOM   361  H HG22 . THR A 1 25  ? -12.70837 -35.92170 -1.66684  1.000 44.87295 ? 25  THR A HG22 1 
ATOM   362  H HG23 . THR A 1 25  ? -12.17678 -34.64050 -2.41981  1.000 44.87295 ? 25  THR A HG23 1 
ATOM   363  N N    . THR A 1 26  ? -10.14052 -37.11057 -1.73616  1.000 30.98764 ? 26  THR A N    1 
ATOM   364  C CA   . THR A 1 26  ? -9.82043  -37.77709 -0.47745  1.000 29.77291 ? 26  THR A CA   1 
ATOM   365  C C    . THR A 1 26  ? -10.05961 -36.81499 0.67505   1.000 28.68672 ? 26  THR A C    1 
ATOM   366  O O    . THR A 1 26  ? -9.74153  -35.62369 0.59390   1.000 28.47027 ? 26  THR A O    1 
ATOM   367  C CB   . THR A 1 26  ? -8.38703  -38.27895 -0.47526  1.000 33.99106 ? 26  THR A CB   1 
ATOM   368  O OG1  . THR A 1 26  ? -8.25885  -39.34025 -1.44587  1.000 32.46913 ? 26  THR A OG1  1 
ATOM   369  C CG2  . THR A 1 26  ? -8.00204  -38.86847 0.86851   1.000 31.78949 ? 26  THR A CG2  1 
ATOM   370  H H    . THR A 1 26  ? -9.72507  -36.36816 -1.85755  1.000 37.18517 ? 26  THR A H    1 
ATOM   371  H HA   . THR A 1 26  ? -10.39987 -38.54463 -0.34813  1.000 35.72749 ? 26  THR A HA   1 
ATOM   372  H HB   . THR A 1 26  ? -7.80256  -37.53136 -0.67559  1.000 40.78928 ? 26  THR A HB   1 
ATOM   373  H HG1  . THR A 1 26  ? -7.54655  -39.76577 -1.31388  1.000 38.96296 ? 26  THR A HG1  1 
ATOM   374  H HG21 . THR A 1 26  ? -7.16862  -39.35776 0.78951   1.000 38.14738 ? 26  THR A HG21 1 
ATOM   375  H HG22 . THR A 1 26  ? -7.89083  -38.16079 1.52199   1.000 38.14738 ? 26  THR A HG22 1 
ATOM   376  H HG23 . THR A 1 26  ? -8.69467  -39.47422 1.17590   1.000 38.14738 ? 26  THR A HG23 1 
ATOM   377  N N    . LEU A 1 27  ? -10.68558 -37.31914 1.72252   1.000 26.31709 ? 27  LEU A N    1 
ATOM   378  C CA   . LEU A 1 27  ? -10.85563 -36.52902 2.92995   1.000 25.16345 ? 27  LEU A CA   1 
ATOM   379  C C    . LEU A 1 27  ? -10.92133 -37.44481 4.13636   1.000 25.10206 ? 27  LEU A C    1 
ATOM   380  O O    . LEU A 1 27  ? -10.73433 -38.65961 4.04868   1.000 19.91246 ? 27  LEU A O    1 
ATOM   381  C CB   . LEU A 1 27  ? -12.09231 -35.63393 2.82507   1.000 21.55482 ? 27  LEU A CB   1 
ATOM   382  C CG   . LEU A 1 27  ? -13.41770 -36.15865 2.27827   1.000 20.06238 ? 27  LEU A CG   1 
ATOM   383  C CD1  . LEU A 1 27  ? -13.89412 -37.27758 3.15842   1.000 26.30848 ? 27  LEU A CD1  1 
ATOM   384  C CD2  . LEU A 1 27  ? -14.43458 -35.02442 2.20862   1.000 20.72686 ? 27  LEU A CD2  1 
ATOM   385  H H    . LEU A 1 27  ? -11.01996 -38.11143 1.75992   1.000 31.58051 ? 27  LEU A H    1 
ATOM   386  H HA   . LEU A 1 27  ? -10.07412 -35.96446 3.04057   1.000 30.19614 ? 27  LEU A HA   1 
ATOM   387  H HB2  . LEU A 1 27  ? -12.28588 -35.31864 3.72219   1.000 25.86578 ? 27  LEU A HB2  1 
ATOM   388  H HB3  . LEU A 1 27  ? -11.84970 -34.88739 2.25561   1.000 25.86578 ? 27  LEU A HB3  1 
ATOM   389  H HG   . LEU A 1 27  ? -13.31011 -36.50201 1.37810   1.000 24.07486 ? 27  LEU A HG   1 
ATOM   390  H HD11 . LEU A 1 27  ? -14.81387 -37.48717 2.93296   1.000 31.57018 ? 27  LEU A HD11 1 
ATOM   391  H HD12 . LEU A 1 27  ? -13.33245 -38.05504 3.01214   1.000 31.57018 ? 27  LEU A HD12 1 
ATOM   392  H HD13 . LEU A 1 27  ? -13.83567 -36.99810 4.08461   1.000 31.57018 ? 27  LEU A HD13 1 
ATOM   393  H HD21 . LEU A 1 27  ? -15.30540 -35.36527 2.46610   1.000 24.87223 ? 27  LEU A HD21 1 
ATOM   394  H HD22 . LEU A 1 27  ? -14.16335 -34.31858 2.81515   1.000 24.87223 ? 27  LEU A HD22 1 
ATOM   395  H HD23 . LEU A 1 27  ? -14.46852 -34.68589 1.29981   1.000 24.87223 ? 27  LEU A HD23 1 
ATOM   396  N N    . ASN A 1 28  ? -11.19122 -36.83973 5.28564   1.000 19.99921 ? 28  ASN A N    1 
ATOM   397  C CA   . ASN A 1 28  ? -11.22304 -37.61152 6.51415   1.000 15.92007 ? 28  ASN A CA   1 
ATOM   398  C C    . ASN A 1 28  ? -12.61576 -38.10884 6.86036   1.000 21.50496 ? 28  ASN A C    1 
ATOM   399  O O    . ASN A 1 28  ? -13.61914 -37.48443 6.52039   1.000 21.72588 ? 28  ASN A O    1 
ATOM   400  C CB   . ASN A 1 28  ? -10.69512 -36.76080 7.65687   1.000 22.42033 ? 28  ASN A CB   1 
ATOM   401  C CG   . ASN A 1 28  ? -9.37948  -36.16656 7.33670   1.000 24.14482 ? 28  ASN A CG   1 
ATOM   402  O OD1  . ASN A 1 28  ? -8.37098  -36.84183 7.45764   1.000 23.44298 ? 28  ASN A OD1  1 
ATOM   403  N ND2  . ASN A 1 28  ? -9.36532  -34.90928 6.90348   1.000 22.53443 ? 28  ASN A ND2  1 
ATOM   404  H H    . ASN A 1 28  ? -11.35492 -36.00092 5.37610   1.000 23.99905 ? 28  ASN A H    1 
ATOM   405  H HA   . ASN A 1 28  ? -10.66837 -38.39900 6.39686   1.000 19.10408 ? 28  ASN A HA   1 
ATOM   406  H HB2  . ASN A 1 28  ? -11.31875 -36.03941 7.83309   1.000 26.90440 ? 28  ASN A HB2  1 
ATOM   407  H HB3  . ASN A 1 28  ? -10.59396 -37.31421 8.44756   1.000 26.90440 ? 28  ASN A HB3  1 
ATOM   408  H HD21 . ASN A 1 28  ? -8.61956  -34.52956 6.70797   1.000 27.04132 ? 28  ASN A HD21 1 
ATOM   409  H HD22 . ASN A 1 28  ? -10.10364 -34.47581 6.82048   1.000 27.04132 ? 28  ASN A HD22 1 
ATOM   410  N N    . GLY A 1 29  ? -12.65809 -39.25730 7.54763   1.000 21.36676 ? 29  GLY A N    1 
ATOM   411  C CA   . GLY A 1 29  ? -13.88785 -39.79360 8.06887   1.000 20.15028 ? 29  GLY A CA   1 
ATOM   412  C C    . GLY A 1 29  ? -13.70101 -40.22734 9.51267   1.000 19.01910 ? 29  GLY A C    1 
ATOM   413  O O    . GLY A 1 29  ? -12.57811 -40.33475 10.01200  1.000 19.87404 ? 29  GLY A O    1 
ATOM   414  H H    . GLY A 1 29  ? -11.96877 -39.74086 7.72058   1.000 25.64011 ? 29  GLY A H    1 
ATOM   415  H HA2  . GLY A 1 29  ? -14.58437 -39.12013 8.03004   1.000 24.18034 ? 29  GLY A HA2  1 
ATOM   416  H HA3  . GLY A 1 29  ? -14.16105 -40.56149 7.54330   1.000 24.18034 ? 29  GLY A HA3  1 
ATOM   417  N N    . LEU A 1 30  ? -14.81702 -40.51063 10.16110  1.000 20.21209 ? 30  LEU A N    1 
ATOM   418  C CA   . LEU A 1 30  ? -14.81925 -40.85151 11.58289  1.000 27.39186 ? 30  LEU A CA   1 
ATOM   419  C C    . LEU A 1 30  ? -15.38715 -42.26801 11.66682  1.000 25.70250 ? 30  LEU A C    1 
ATOM   420  O O    . LEU A 1 30  ? -16.54985 -42.48871 11.30227  1.000 20.01332 ? 30  LEU A O    1 
ATOM   421  C CB   . LEU A 1 30  ? -15.69530 -39.88569 12.36918  1.000 15.09196 ? 30  LEU A CB   1 
ATOM   422  C CG   . LEU A 1 30  ? -15.84967 -40.08474 13.88100  1.000 18.31622 ? 30  LEU A CG   1 
ATOM   423  C CD1  . LEU A 1 30  ? -14.49006 -39.86904 14.49761  1.000 22.87789 ? 30  LEU A CD1  1 
ATOM   424  C CD2  . LEU A 1 30  ? -16.82663 -39.10183 14.38626  1.000 22.65266 ? 30  LEU A CD2  1 
ATOM   425  H H    . LEU A 1 30  ? -15.59689 -40.51503 9.79882   1.000 24.25450 ? 30  LEU A H    1 
ATOM   426  H HA   . LEU A 1 30  ? -13.92541 -40.81603 11.95923  1.000 32.87023 ? 30  LEU A HA   1 
ATOM   427  H HB2  . LEU A 1 30  ? -15.32996 -38.99532 12.24585  1.000 18.11035 ? 30  LEU A HB2  1 
ATOM   428  H HB3  . LEU A 1 30  ? -16.58813 -39.93317 11.99383  1.000 18.11035 ? 30  LEU A HB3  1 
ATOM   429  H HG   . LEU A 1 30  ? -16.17005 -40.97114 14.11034  1.000 21.97947 ? 30  LEU A HG   1 
ATOM   430  H HD11 . LEU A 1 30  ? -14.53924 -40.06366 15.44747  1.000 27.45347 ? 30  LEU A HD11 1 
ATOM   431  H HD12 . LEU A 1 30  ? -13.85144 -40.46227 14.07147  1.000 27.45347 ? 30  LEU A HD12 1 
ATOM   432  H HD13 . LEU A 1 30  ? -14.22475 -38.94574 14.36227  1.000 27.45347 ? 30  LEU A HD13 1 
ATOM   433  H HD21 . LEU A 1 30  ? -16.91289 -39.20649 15.34717  1.000 27.18320 ? 30  LEU A HD21 1 
ATOM   434  H HD22 . LEU A 1 30  ? -16.51227 -38.20745 14.17892  1.000 27.18320 ? 30  LEU A HD22 1 
ATOM   435  H HD23 . LEU A 1 30  ? -17.68336 -39.25825 13.95886  1.000 27.18320 ? 30  LEU A HD23 1 
ATOM   436  N N    . TRP A 1 31  ? -14.56758 -43.20565 12.14753  1.000 22.21942 ? 31  TRP A N    1 
ATOM   437  C CA   . TRP A 1 31  ? -14.89446 -44.63095 12.20253  1.000 20.68380 ? 31  TRP A CA   1 
ATOM   438  C C    . TRP A 1 31  ? -15.29770 -44.96915 13.63518  1.000 21.77132 ? 31  TRP A C    1 
ATOM   439  O O    . TRP A 1 31  ? -14.44397 -45.02503 14.53045  1.000 22.14243 ? 31  TRP A O    1 
ATOM   440  C CB   . TRP A 1 31  ? -13.70263 -45.48273 11.76343  1.000 24.51951 ? 31  TRP A CB   1 
ATOM   441  C CG   . TRP A 1 31  ? -13.93744 -46.98493 11.77442  1.000 29.71094 ? 31  TRP A CG   1 
ATOM   442  C CD1  . TRP A 1 31  ? -15.14193 -47.63590 11.80659  1.000 30.24228 ? 31  TRP A CD1  1 
ATOM   443  C CD2  . TRP A 1 31  ? -12.92762 -48.02114 11.80614  1.000 33.43285 ? 31  TRP A CD2  1 
ATOM   444  N NE1  . TRP A 1 31  ? -14.94285 -49.00176 11.82682  1.000 29.78049 ? 31  TRP A NE1  1 
ATOM   445  C CE2  . TRP A 1 31  ? -13.59665 -49.25969 11.83414  1.000 24.25793 ? 31  TRP A CE2  1 
ATOM   446  C CE3  . TRP A 1 31  ? -11.52863 -48.01403 11.81663  1.000 33.28605 ? 31  TRP A CE3  1 
ATOM   447  C CZ2  . TRP A 1 31  ? -12.91468 -50.47616 11.85563  1.000 25.49885 ? 31  TRP A CZ2  1 
ATOM   448  C CZ3  . TRP A 1 31  ? -10.84966 -49.23350 11.83212  1.000 37.60176 ? 31  TRP A CZ3  1 
ATOM   449  C CH2  . TRP A 1 31  ? -11.54771 -50.44408 11.85713  1.000 33.58335 ? 31  TRP A CH2  1 
ATOM   450  H H    . TRP A 1 31  ? -13.78582 -43.03223 12.46091  1.000 26.66330 ? 31  TRP A H    1 
ATOM   451  H HA   . TRP A 1 31  ? -15.63910 -44.81518 11.60916  1.000 24.82056 ? 31  TRP A HA   1 
ATOM   452  H HB2  . TRP A 1 31  ? -13.46650 -45.23398 10.85566  1.000 29.42341 ? 31  TRP A HB2  1 
ATOM   453  H HB3  . TRP A 1 31  ? -12.95998 -45.30251 12.36080  1.000 29.42341 ? 31  TRP A HB3  1 
ATOM   454  H HD1  . TRP A 1 31  ? -15.97326 -47.21857 11.81256  1.000 36.29073 ? 31  TRP A HD1  1 
ATOM   455  H HE1  . TRP A 1 31  ? -15.56438 -49.59626 11.83423  1.000 35.73658 ? 31  TRP A HE1  1 
ATOM   456  H HE3  . TRP A 1 31  ? -11.05927 -47.21166 11.81429  1.000 39.94326 ? 31  TRP A HE3  1 
ATOM   457  H HZ2  . TRP A 1 31  ? -13.37605 -51.28354 11.86697  1.000 30.59862 ? 31  TRP A HZ2  1 
ATOM   458  H HZ3  . TRP A 1 31  ? -9.91966  -49.24076 11.82445  1.000 45.12211 ? 31  TRP A HZ3  1 
ATOM   459  H HH2  . TRP A 1 31  ? -11.07308 -51.24371 11.87680  1.000 40.30002 ? 31  TRP A HH2  1 
ATOM   460  N N    . LEU A 1 32  ? -16.58758 -45.21331 13.83858  1.000 20.02213 ? 32  LEU A N    1 
ATOM   461  C CA   . LEU A 1 32  ? -17.17176 -45.55656 15.11916  1.000 26.15054 ? 32  LEU A CA   1 
ATOM   462  C C    . LEU A 1 32  ? -18.03671 -46.79114 14.94309  1.000 29.19395 ? 32  LEU A C    1 
ATOM   463  O O    . LEU A 1 32  ? -18.91539 -46.80831 14.07677  1.000 22.83083 ? 32  LEU A O    1 
ATOM   464  C CB   . LEU A 1 32  ? -18.03585 -44.40756 15.62756  1.000 28.02235 ? 32  LEU A CB   1 
ATOM   465  C CG   . LEU A 1 32  ? -17.32601 -43.10822 15.99261  1.000 25.84792 ? 32  LEU A CG   1 
ATOM   466  C CD1  . LEU A 1 32  ? -18.42290 -42.09524 16.22985  1.000 23.44066 ? 32  LEU A CD1  1 
ATOM   467  C CD2  . LEU A 1 32  ? -16.52534 -43.26236 17.25780  1.000 22.65088 ? 32  LEU A CD2  1 
ATOM   468  H H    . LEU A 1 32  ? -17.17438 -45.18339 13.21139  1.000 24.02656 ? 32  LEU A H    1 
ATOM   469  H HA   . LEU A 1 32  ? -16.47383 -45.74840 15.76429  1.000 31.38065 ? 32  LEU A HA   1 
ATOM   470  H HB2  . LEU A 1 32  ? -18.68078 -44.19165 14.93547  1.000 33.62682 ? 32  LEU A HB2  1 
ATOM   471  H HB3  . LEU A 1 32  ? -18.49489 -44.71142 16.42621  1.000 33.62682 ? 32  LEU A HB3  1 
ATOM   472  H HG   . LEU A 1 32  ? -16.71198 -42.83730 15.29300  1.000 31.01751 ? 32  LEU A HG   1 
ATOM   473  H HD11 . LEU A 1 32  ? -18.02166 -41.24206 16.45652  1.000 28.12879 ? 32  LEU A HD11 1 
ATOM   474  H HD12 . LEU A 1 32  ? -18.95169 -42.00816 15.42172  1.000 28.12879 ? 32  LEU A HD12 1 
ATOM   475  H HD13 . LEU A 1 32  ? -18.98292 -42.40214 16.95946  1.000 28.12879 ? 32  LEU A HD13 1 
ATOM   476  H HD21 . LEU A 1 32  ? -16.13210 -42.40619 17.48947  1.000 27.18105 ? 32  LEU A HD21 1 
ATOM   477  H HD22 . LEU A 1 32  ? -17.11335 -43.56027 17.96941  1.000 27.18105 ? 32  LEU A HD22 1 
ATOM   478  H HD23 . LEU A 1 32  ? -15.82576 -43.91772 17.11064  1.000 27.18105 ? 32  LEU A HD23 1 
ATOM   479  N N    . ASP A 1 33  ? -17.82120 -47.80049 15.78455  1.000 32.02534 ? 33  ASP A N    1 
ATOM   480  C CA   . ASP A 1 33  ? -18.49212 -49.08691 15.60052  1.000 34.43741 ? 33  ASP A CA   1 
ATOM   481  C C    . ASP A 1 33  ? -18.24229 -49.47781 14.14136  1.000 29.72381 ? 33  ASP A C    1 
ATOM   482  O O    . ASP A 1 33  ? -17.10122 -49.35461 13.66384  1.000 28.59349 ? 33  ASP A O    1 
ATOM   483  C CB   . ASP A 1 33  ? -19.96135 -48.97833 16.01206  1.000 23.65136 ? 33  ASP A CB   1 
ATOM   484  C CG   . ASP A 1 33  ? -20.13021 -48.54237 17.47827  1.000 37.02389 ? 33  ASP A CG   1 
ATOM   485  O OD1  . ASP A 1 33  ? -19.33017 -48.97926 18.33729  1.000 38.52443 ? 33  ASP A OD1  1 
ATOM   486  O OD2  . ASP A 1 33  ? -21.08292 -47.78732 17.78640  1.000 41.20789 ? 33  ASP A OD2  1 
ATOM   487  H H    . ASP A 1 33  ? -17.29547 -47.76449 16.46375  1.000 38.43040 ? 33  ASP A H    1 
ATOM   488  H HA   . ASP A 1 33  ? -18.08379 -49.75294 16.17625  1.000 41.32489 ? 33  ASP A HA   1 
ATOM   489  H HB2  . ASP A 1 33  ? -20.40067 -48.32134 15.44931  1.000 28.38163 ? 33  ASP A HB2  1 
ATOM   490  H HB3  . ASP A 1 33  ? -20.38562 -49.84361 15.90438  1.000 28.38163 ? 33  ASP A HB3  1 
ATOM   491  N N    . ASP A 1 34  ? -19.25866 -49.94417 13.40372  1.000 24.23044 ? 34  ASP A N    1 
ATOM   492  C CA   . ASP A 1 34  ? -19.05882 -50.38816 12.03451  1.000 23.53126 ? 34  ASP A CA   1 
ATOM   493  C C    . ASP A 1 34  ? -19.55031 -49.33894 11.04299  1.000 34.63950 ? 34  ASP A C    1 
ATOM   494  O O    . ASP A 1 34  ? -20.00664 -49.68263 9.94461   1.000 29.85419 ? 34  ASP A O    1 
ATOM   495  C CB   . ASP A 1 34  ? -19.77266 -51.71956 11.74744  1.000 30.82101 ? 34  ASP A CB   1 
ATOM   496  C CG   . ASP A 1 34  ? -21.25179 -51.70695 12.09693  1.000 38.19836 ? 34  ASP A CG   1 
ATOM   497  O OD1  . ASP A 1 34  ? -21.72879 -50.68464 12.60039  1.000 40.33024 ? 34  ASP A OD1  1 
ATOM   498  O OD2  . ASP A 1 34  ? -21.94789 -52.73536 11.86805  1.000 38.26989 ? 34  ASP A OD2  1 
ATOM   499  H H    . ASP A 1 34  ? -20.06970 -50.00899 13.68239  1.000 29.07652 ? 34  ASP A H    1 
ATOM   500  H HA   . ASP A 1 34  ? -18.10766 -50.53533 11.91276  1.000 28.23751 ? 34  ASP A HA   1 
ATOM   501  H HB2  . ASP A 1 34  ? -19.69317 -51.91991 10.80134  1.000 36.98521 ? 34  ASP A HB2  1 
ATOM   502  H HB3  . ASP A 1 34  ? -19.35029 -52.41954 12.27016  1.000 36.98521 ? 34  ASP A HB3  1 
ATOM   503  N N    . VAL A 1 35  ? -19.49845 -48.05713 11.40479  1.000 26.80275 ? 35  VAL A N    1 
ATOM   504  C CA   . VAL A 1 35  ? -19.92098 -46.99290 10.48630  1.000 29.43070 ? 35  VAL A CA   1 
ATOM   505  C C    . VAL A 1 35  ? -18.81374 -45.96692 10.33732  1.000 29.99514 ? 35  VAL A C    1 
ATOM   506  O O    . VAL A 1 35  ? -18.18041 -45.56502 11.32180  1.000 22.06406 ? 35  VAL A O    1 
ATOM   507  C CB   . VAL A 1 35  ? -21.21170 -46.30623 10.98127  1.000 20.30293 ? 35  VAL A CB   1 
ATOM   508  C CG1  . VAL A 1 35  ? -21.64426 -45.20001 10.07780  1.000 26.99227 ? 35  VAL A CG1  1 
ATOM   509  C CG2  . VAL A 1 35  ? -22.32993 -47.32620 11.11725  1.000 28.56795 ? 35  VAL A CG2  1 
ATOM   510  H H    . VAL A 1 35  ? -19.22395 -47.77838 12.17106  1.000 32.16330 ? 35  VAL A H    1 
ATOM   511  H HA   . VAL A 1 35  ? -20.07835 -47.38648 9.61400   1.000 35.31684 ? 35  VAL A HA   1 
ATOM   512  H HB   . VAL A 1 35  ? -21.02132 -45.91461 11.84758  1.000 24.36352 ? 35  VAL A HB   1 
ATOM   513  H HG11 . VAL A 1 35  ? -22.58645 -45.02186 10.22558  1.000 32.39072 ? 35  VAL A HG11 1 
ATOM   514  H HG12 . VAL A 1 35  ? -21.12196 -44.40672 10.27647  1.000 32.39072 ? 35  VAL A HG12 1 
ATOM   515  H HG13 . VAL A 1 35  ? -21.49872 -45.46933 9.15668   1.000 32.39072 ? 35  VAL A HG13 1 
ATOM   516  H HG21 . VAL A 1 35  ? -23.14539 -46.86801 11.37624  1.000 34.28154 ? 35  VAL A HG21 1 
ATOM   517  H HG22 . VAL A 1 35  ? -22.45728 -47.77078 10.26493  1.000 34.28154 ? 35  VAL A HG22 1 
ATOM   518  H HG23 . VAL A 1 35  ? -22.08466 -47.97443 11.79593  1.000 34.28154 ? 35  VAL A HG23 1 
ATOM   519  N N    . VAL A 1 36  ? -18.60867 -45.50700 9.11468   1.000 26.84226 ? 36  VAL A N    1 
ATOM   520  C CA   . VAL A 1 36  ? -17.70145 -44.41312 8.84967   1.000 26.41729 ? 36  VAL A CA   1 
ATOM   521  C C    . VAL A 1 36  ? -18.56425 -43.23455 8.44410   1.000 29.10563 ? 36  VAL A C    1 
ATOM   522  O O    . VAL A 1 36  ? -19.44783 -43.37473 7.59170   1.000 22.96761 ? 36  VAL A O    1 
ATOM   523  C CB   . VAL A 1 36  ? -16.66777 -44.79164 7.78781   1.000 25.25124 ? 36  VAL A CB   1 
ATOM   524  C CG1  . VAL A 1 36  ? -15.81257 -43.62973 7.42182   1.000 24.26979 ? 36  VAL A CG1  1 
ATOM   525  C CG2  . VAL A 1 36  ? -15.83705 -45.93731 8.32039   1.000 32.65112 ? 36  VAL A CG2  1 
ATOM   526  H H    . VAL A 1 36  ? -18.99217 -45.82188 8.41235   1.000 32.21071 ? 36  VAL A H    1 
ATOM   527  H HA   . VAL A 1 36  ? -17.19993 -44.16621 9.64400   1.000 31.70075 ? 36  VAL A HA   1 
ATOM   528  H HB   . VAL A 1 36  ? -17.11627 -45.06550 6.97248   1.000 30.30149 ? 36  VAL A HB   1 
ATOM   529  H HG11 . VAL A 1 36  ? -15.07213 -43.94181 6.87789   1.000 29.12375 ? 36  VAL A HG11 1 
ATOM   530  H HG12 . VAL A 1 36  ? -16.34490 -42.99185 6.92203   1.000 29.12375 ? 36  VAL A HG12 1 
ATOM   531  H HG13 . VAL A 1 36  ? -15.47718 -43.21797 8.23320   1.000 29.12375 ? 36  VAL A HG13 1 
ATOM   532  H HG21 . VAL A 1 36  ? -15.20559 -46.21439 7.63844   1.000 39.18134 ? 36  VAL A HG21 1 
ATOM   533  H HG22 . VAL A 1 36  ? -15.36056 -45.64142 9.11174   1.000 39.18134 ? 36  VAL A HG22 1 
ATOM   534  H HG23 . VAL A 1 36  ? -16.42554 -46.67592 8.54573   1.000 39.18134 ? 36  VAL A HG23 1 
ATOM   535  N N    . TYR A 1 37  ? -18.33939 -42.08677 9.09288   1.000 21.03460 ? 37  TYR A N    1 
ATOM   536  C CA   . TYR A 1 37  ? -19.03527 -40.85114 8.79340   1.000 22.20821 ? 37  TYR A CA   1 
ATOM   537  C C    . TYR A 1 37  ? -18.06574 -39.93393 8.07831   1.000 19.60913 ? 37  TYR A C    1 
ATOM   538  O O    . TYR A 1 37  ? -16.91998 -39.81928 8.50078   1.000 22.27293 ? 37  TYR A O    1 
ATOM   539  C CB   . TYR A 1 37  ? -19.52424 -40.18631 10.05164  1.000 21.84681 ? 37  TYR A CB   1 
ATOM   540  C CG   . TYR A 1 37  ? -20.38883 -41.07151 10.88579  1.000 22.84129 ? 37  TYR A CG   1 
ATOM   541  C CD1  . TYR A 1 37  ? -19.82637 -42.02057 11.70740  1.000 25.38153 ? 37  TYR A CD1  1 
ATOM   542  C CD2  . TYR A 1 37  ? -21.75188 -40.97956 10.82436  1.000 20.75091 ? 37  TYR A CD2  1 
ATOM   543  C CE1  . TYR A 1 37  ? -20.61800 -42.83269 12.50262  1.000 29.36954 ? 37  TYR A CE1  1 
ATOM   544  C CE2  . TYR A 1 37  ? -22.55950 -41.79767 11.59157  1.000 22.80873 ? 37  TYR A CE2  1 
ATOM   545  C CZ   . TYR A 1 37  ? -21.98005 -42.73173 12.42320  1.000 22.80800 ? 37  TYR A CZ   1 
ATOM   546  O OH   . TYR A 1 37  ? -22.75267 -43.55982 13.19542  1.000 25.82741 ? 37  TYR A OH   1 
ATOM   547  H H    . TYR A 1 37  ? -17.76768 -42.00671 9.73114   1.000 25.24152 ? 37  TYR A H    1 
ATOM   548  H HA   . TYR A 1 37  ? -19.80293 -41.02741 8.22602   1.000 26.64985 ? 37  TYR A HA   1 
ATOM   549  H HB2  . TYR A 1 37  ? -18.75864 -39.92603 10.58707  1.000 26.21617 ? 37  TYR A HB2  1 
ATOM   550  H HB3  . TYR A 1 37  ? -20.04378 -39.40257 9.81094   1.000 26.21617 ? 37  TYR A HB3  1 
ATOM   551  H HD1  . TYR A 1 37  ? -18.90129 -42.11885 11.72867  1.000 30.45784 ? 37  TYR A HD1  1 
ATOM   552  H HD2  . TYR A 1 37  ? -22.14218 -40.35552 10.25661  1.000 24.90110 ? 37  TYR A HD2  1 
ATOM   553  H HE1  . TYR A 1 37  ? -20.22672 -43.44174 13.08638  1.000 35.24345 ? 37  TYR A HE1  1 
ATOM   554  H HE2  . TYR A 1 37  ? -23.48555 -41.71838 11.54730  1.000 27.37048 ? 37  TYR A HE2  1 
ATOM   555  H HH   . TYR A 1 37  ? -23.55784 -43.32743 13.14928  1.000 30.99289 ? 37  TYR A HH   1 
ATOM   556  N N    . CYS A 1 38  ? -18.50686 -39.30061 6.98854   1.000 22.13853 ? 38  CYS A N    1 
ATOM   557  C CA   . CYS A 1 38  ? -17.67242 -38.30953 6.32245   1.000 16.40681 ? 38  CYS A CA   1 
ATOM   558  C C    . CYS A 1 38  ? -18.56592 -37.33477 5.55473   1.000 14.53957 ? 38  CYS A C    1 
ATOM   559  O O    . CYS A 1 38  ? -19.75766 -37.58461 5.38116   1.000 19.48291 ? 38  CYS A O    1 
ATOM   560  C CB   . CYS A 1 38  ? -16.65256 -38.96415 5.39040   1.000 21.76708 ? 38  CYS A CB   1 
ATOM   561  S SG   . CYS A 1 38  ? -17.38450 -39.63381 3.89573   1.000 24.14006 ? 38  CYS A SG   1 
ATOM   562  H H    . CYS A 1 38  ? -19.27563 -39.42800 6.62419   1.000 26.56624 ? 38  CYS A H    1 
ATOM   563  H HA   . CYS A 1 38  ? -17.19406 -37.80457 6.99893   1.000 19.68817 ? 38  CYS A HA   1 
ATOM   564  H HB2  . CYS A 1 38  ? -15.99600 -38.29946 5.12905   1.000 26.12050 ? 38  CYS A HB2  1 
ATOM   565  H HB3  . CYS A 1 38  ? -16.21815 -39.69209 5.86211   1.000 26.12050 ? 38  CYS A HB3  1 
ATOM   566  H HG   . CYS A 1 38  ? -17.92100 -38.74686 3.29109   1.000 28.96808 ? 38  CYS A HG   1 
ATOM   567  N N    . PRO A 1 39  ? -18.01166 -36.20506 5.10863   1.000 17.42551 ? 39  PRO A N    1 
ATOM   568  C CA   . PRO A 1 39  ? -18.81916 -35.24623 4.34593   1.000 15.51761 ? 39  PRO A CA   1 
ATOM   569  C C    . PRO A 1 39  ? -19.24119 -35.87275 3.02540   1.000 18.02345 ? 39  PRO A C    1 
ATOM   570  O O    . PRO A 1 39  ? -18.47239 -36.59775 2.38722   1.000 18.24711 ? 39  PRO A O    1 
ATOM   571  C CB   . PRO A 1 39  ? -17.87804 -34.04635 4.14600   1.000 14.28086 ? 39  PRO A CB   1 
ATOM   572  C CG   . PRO A 1 39  ? -16.90838 -34.11928 5.27730   1.000 16.38625 ? 39  PRO A CG   1 
ATOM   573  C CD   . PRO A 1 39  ? -16.69024 -35.62721 5.44745   1.000 17.32464 ? 39  PRO A CD   1 
ATOM   574  H HA   . PRO A 1 39  ? -19.59557 -34.94815 4.84584   1.000 18.62114 ? 39  PRO A HA   1 
ATOM   575  H HB2  . PRO A 1 39  ? -17.42268 -34.12347 3.29312   1.000 17.13703 ? 39  PRO A HB2  1 
ATOM   576  H HB3  . PRO A 1 39  ? -18.38671 -33.22078 4.17733   1.000 17.13703 ? 39  PRO A HB3  1 
ATOM   577  H HG2  . PRO A 1 39  ? -16.08266 -33.66548 5.04587   1.000 19.66350 ? 39  PRO A HG2  1 
ATOM   578  H HG3  . PRO A 1 39  ? -17.28998 -33.72408 6.07741   1.000 19.66350 ? 39  PRO A HG3  1 
ATOM   579  H HD2  . PRO A 1 39  ? -16.00777 -35.94829 4.83749   1.000 20.78957 ? 39  PRO A HD2  1 
ATOM   580  H HD3  . PRO A 1 39  ? -16.44539 -35.83958 6.36140   1.000 20.78957 ? 39  PRO A HD3  1 
ATOM   581  N N    . ARG A 1 40  ? -20.46927 -35.59548 2.63113   1.000 16.92410 ? 40  ARG A N    1 
ATOM   582  C CA   . ARG A 1 40  ? -20.97235 -36.21313 1.40457   1.000 17.09815 ? 40  ARG A CA   1 
ATOM   583  C C    . ARG A 1 40  ? -20.30138 -35.62384 0.17117   1.000 23.13402 ? 40  ARG A C    1 
ATOM   584  O O    . ARG A 1 40  ? -20.31149 -36.26919 -0.88123  1.000 18.19748 ? 40  ARG A O    1 
ATOM   585  C CB   . ARG A 1 40  ? -22.49343 -36.06327 1.29413   1.000 16.78228 ? 40  ARG A CB   1 
ATOM   586  C CG   . ARG A 1 40  ? -22.96052 -34.66260 1.22383   1.000 21.73894 ? 40  ARG A CG   1 
ATOM   587  C CD   . ARG A 1 40  ? -24.44647 -34.65769 1.06931   1.000 18.99617 ? 40  ARG A CD   1 
ATOM   588  N NE   . ARG A 1 40  ? -24.94147 -33.30795 0.86297   1.000 20.21975 ? 40  ARG A NE   1 
ATOM   589  C CZ   . ARG A 1 40  ? -26.20362 -33.01682 0.63370   1.000 18.41833 ? 40  ARG A CZ   1 
ATOM   590  N NH1  . ARG A 1 40  ? -27.10380 -33.97444 0.47779   1.000 23.38913 ? 40  ARG A NH1  1 
ATOM   591  N NH2  . ARG A 1 40  ? -26.56660 -31.74505 0.53736   1.000 17.91203 ? 40  ARG A NH2  1 
ATOM   592  H H    . ARG A 1 40  ? -21.01883 -35.07317 3.03726   1.000 20.30891 ? 40  ARG A H    1 
ATOM   593  H HA   . ARG A 1 40  ? -20.78660 -37.16500 1.43705   1.000 20.51778 ? 40  ARG A HA   1 
ATOM   594  H HB2  . ARG A 1 40  ? -22.79179 -36.51401 0.48975   1.000 20.13874 ? 40  ARG A HB2  1 
ATOM   595  H HB3  . ARG A 1 40  ? -22.90238 -36.47108 2.07373   1.000 20.13874 ? 40  ARG A HB3  1 
ATOM   596  H HG2  . ARG A 1 40  ? -22.72618 -34.19292 2.04020   1.000 26.08673 ? 40  ARG A HG2  1 
ATOM   597  H HG3  . ARG A 1 40  ? -22.56160 -34.21781 0.45924   1.000 26.08673 ? 40  ARG A HG3  1 
ATOM   598  H HD2  . ARG A 1 40  ? -24.69377 -35.19641 0.30189   1.000 22.79541 ? 40  ARG A HD2  1 
ATOM   599  H HD3  . ARG A 1 40  ? -24.85647 -35.01651 1.87194   1.000 22.79541 ? 40  ARG A HD3  1 
ATOM   600  H HE   . ARG A 1 40  ? -24.37600 -32.66052 0.89256   1.000 24.26370 ? 40  ARG A HE   1 
ATOM   601  H HH11 . ARG A 1 40  ? -26.86716 -34.79928 0.52537   1.000 28.06696 ? 40  ARG A HH11 1 
ATOM   602  H HH12 . ARG A 1 40  ? -27.92591 -33.77100 0.32763   1.000 28.06696 ? 40  ARG A HH12 1 
ATOM   603  H HH21 . ARG A 1 40  ? -25.98013 -31.12263 0.62395   1.000 21.49444 ? 40  ARG A HH21 1 
ATOM   604  H HH22 . ARG A 1 40  ? -27.38971 -31.54361 0.38719   1.000 21.49444 ? 40  ARG A HH22 1 
ATOM   605  N N    . HIS A 1 41  ? -19.67636 -34.43841 0.28313   1.000 18.08305 ? 41  HIS A N    1 
ATOM   606  C CA   . HIS A 1 41  ? -18.99936 -33.90312 -0.92431  1.000 18.97024 ? 41  HIS A CA   1 
ATOM   607  C C    . HIS A 1 41  ? -17.75764 -34.66393 -1.25134  1.000 23.62981 ? 41  HIS A C    1 
ATOM   608  O O    . HIS A 1 41  ? -17.11459 -34.30884 -2.18789  1.000 21.87693 ? 41  HIS A O    1 
ATOM   609  C CB   . HIS A 1 41  ? -18.76861 -32.37800 -0.82328  1.000 15.97130 ? 41  HIS A CB   1 
ATOM   610  C CG   . HIS A 1 41  ? -17.79134 -31.92586 0.21934   1.000 20.02178 ? 41  HIS A CG   1 
ATOM   611  N ND1  . HIS A 1 41  ? -16.43414 -32.12271 0.10270   1.000 27.33280 ? 41  HIS A ND1  1 
ATOM   612  C CD2  . HIS A 1 41  ? -17.96334 -31.15968 1.31975   1.000 19.37678 ? 41  HIS A CD2  1 
ATOM   613  C CE1  . HIS A 1 41  ? -15.81396 -31.55485 1.12627   1.000 20.65985 ? 41  HIS A CE1  1 
ATOM   614  N NE2  . HIS A 1 41  ? -16.72569 -30.97004 1.88631   1.000 22.49215 ? 41  HIS A NE2  1 
ATOM   615  H H    . HIS A 1 41  ? -19.63100 -33.95781 0.99444   1.000 21.69965 ? 41  HIS A H    1 
ATOM   616  H HA   . HIS A 1 41  ? -19.59102 -33.99412 -1.68757  1.000 22.76429 ? 41  HIS A HA   1 
ATOM   617  H HB2  . HIS A 1 41  ? -18.43856 -32.06421 -1.67997  1.000 19.16556 ? 41  HIS A HB2  1 
ATOM   618  H HB3  . HIS A 1 41  ? -19.61802 -31.95580 -0.62032  1.000 19.16556 ? 41  HIS A HB3  1 
ATOM   619  H HD2  . HIS A 1 41  ? -18.77072 -30.82352 1.63568   1.000 23.25214 ? 41  HIS A HD2  1 
ATOM   620  H HE1  . HIS A 1 41  ? -14.89800 -31.56522 1.28258   1.000 24.79182 ? 41  HIS A HE1  1 
ATOM   621  H HE2  . HIS A 1 41  ? -16.56929 -30.54137 2.61563   1.000 26.99058 ? 41  HIS A HE2  1 
ATOM   622  N N    . VAL A 1 42  ? -17.46500 -35.77113 -0.55792  1.000 21.69821 ? 42  VAL A N    1 
ATOM   623  C CA   . VAL A 1 42  ? -16.37616 -36.63599 -0.99506  1.000 19.13826 ? 42  VAL A CA   1 
ATOM   624  C C    . VAL A 1 42  ? -16.68120 -37.22638 -2.37554  1.000 20.54603 ? 42  VAL A C    1 
ATOM   625  O O    . VAL A 1 42  ? -15.77861 -37.65422 -3.09148  1.000 26.17122 ? 42  VAL A O    1 
ATOM   626  C CB   . VAL A 1 42  ? -16.10963 -37.75541 0.02534   1.000 17.82445 ? 42  VAL A CB   1 
ATOM   627  C CG1  . VAL A 1 42  ? -17.23584 -38.75130 0.02133   1.000 18.63898 ? 42  VAL A CG1  1 
ATOM   628  C CG2  . VAL A 1 42  ? -14.78696 -38.45316 -0.29662  1.000 25.19112 ? 42  VAL A CG2  1 
ATOM   629  H H    . VAL A 1 42  ? -17.87505 -36.03289 0.15078   1.000 26.03786 ? 42  VAL A H    1 
ATOM   630  H HA   . VAL A 1 42  ? -15.56857 -36.10131 -1.04945  1.000 22.96591 ? 42  VAL A HA   1 
ATOM   631  H HB   . VAL A 1 42  ? -16.05025 -37.36791 0.91160   1.000 21.38934 ? 42  VAL A HB   1 
ATOM   632  H HG11 . VAL A 1 42  ? -17.16667 -39.30774 0.81201   1.000 22.36678 ? 42  VAL A HG11 1 
ATOM   633  H HG12 . VAL A 1 42  ? -18.07922 -38.27298 0.02533   1.000 22.36678 ? 42  VAL A HG12 1 
ATOM   634  H HG13 . VAL A 1 42  ? -17.17012 -39.29876 -0.77599  1.000 22.36678 ? 42  VAL A HG13 1 
ATOM   635  H HG21 . VAL A 1 42  ? -14.43892 -38.85938 0.51325   1.000 30.22934 ? 42  VAL A HG21 1 
ATOM   636  H HG22 . VAL A 1 42  ? -14.94418 -39.13487 -0.96710  1.000 30.22934 ? 42  VAL A HG22 1 
ATOM   637  H HG23 . VAL A 1 42  ? -14.15736 -37.79645 -0.63300  1.000 30.22934 ? 42  VAL A HG23 1 
ATOM   638  N N    . ILE A 1 43  ? -17.95904 -37.26817 -2.75101  1.000 19.06819 ? 43  ILE A N    1 
ATOM   639  C CA   . ILE A 1 43  ? -18.36513 -37.84471 -4.02751  1.000 22.69692 ? 43  ILE A CA   1 
ATOM   640  C C    . ILE A 1 43  ? -18.33553 -36.83498 -5.16088  1.000 25.83109 ? 43  ILE A C    1 
ATOM   641  O O    . ILE A 1 43  ? -18.70486 -37.18058 -6.29122  1.000 26.28324 ? 43  ILE A O    1 
ATOM   642  C CB   . ILE A 1 43  ? -19.77868 -38.45791 -3.90639  1.000 21.98464 ? 43  ILE A CB   1 
ATOM   643  C CG1  . ILE A 1 43  ? -20.82259 -37.34678 -3.83907  1.000 22.67916 ? 43  ILE A CG1  1 
ATOM   644  C CG2  . ILE A 1 43  ? -19.87234 -39.41371 -2.73001  1.000 26.62789 ? 43  ILE A CG2  1 
ATOM   645  C CD1  . ILE A 1 43  ? -22.25928 -37.83106 -3.62088  1.000 23.10511 ? 43  ILE A CD1  1 
ATOM   646  H H    . ILE A 1 43  ? -18.61244 -36.96798 -2.27906  1.000 22.88182 ? 43  ILE A H    1 
ATOM   647  H HA   . ILE A 1 43  ? -17.73649 -38.54707 -4.25472  1.000 27.23631 ? 43  ILE A HA   1 
ATOM   648  H HB   . ILE A 1 43  ? -19.95698 -38.98656 -4.70078  1.000 26.38157 ? 43  ILE A HB   1 
ATOM   649  H HG12 . ILE A 1 43  ? -20.59732 -36.75705 -3.10263  1.000 27.21499 ? 43  ILE A HG12 1 
ATOM   650  H HG13 . ILE A 1 43  ? -20.80369 -36.85525 -4.67476  1.000 27.21499 ? 43  ILE A HG13 1 
ATOM   651  H HG21 . ILE A 1 43  ? -20.47168 -40.14004 -2.96067  1.000 31.95347 ? 43  ILE A HG21 1 
ATOM   652  H HG22 . ILE A 1 43  ? -18.98813 -39.76212 -2.53491  1.000 31.95347 ? 43  ILE A HG22 1 
ATOM   653  H HG23 . ILE A 1 43  ? -20.21499 -38.93345 -1.95984  1.000 31.95347 ? 43  ILE A HG23 1 
ATOM   654  H HD11 . ILE A 1 43  ? -22.87266 -37.18531 -4.00570  1.000 27.72613 ? 43  ILE A HD11 1 
ATOM   655  H HD12 . ILE A 1 43  ? -22.37145 -38.69188 -4.05445  1.000 27.72613 ? 43  ILE A HD12 1 
ATOM   656  H HD13 . ILE A 1 43  ? -22.42255 -37.91677 -2.66899  1.000 27.72613 ? 43  ILE A HD13 1 
ATOM   657  N N    . CYS A 1 44  ? -17.89259 -35.61178 -4.91597  1.000 22.76373 ? 44  CYS A N    1 
ATOM   658  C CA   . CYS A 1 44  ? -17.96708 -34.55323 -5.91134  1.000 29.41695 ? 44  CYS A CA   1 
ATOM   659  C C    . CYS A 1 44  ? -16.61302 -34.33674 -6.57773  1.000 35.41262 ? 44  CYS A C    1 
ATOM   660  O O    . CYS A 1 44  ? -15.57022 -34.37432 -5.91639  1.000 30.00900 ? 44  CYS A O    1 
ATOM   661  C CB   . CYS A 1 44  ? -18.40635 -33.24497 -5.27169  1.000 28.75695 ? 44  CYS A CB   1 
ATOM   662  S SG   . CYS A 1 44  ? -20.12153 -33.26067 -4.73731  1.000 26.91792 ? 44  CYS A SG   1 
ATOM   663  H H    . CYS A 1 44  ? -17.54005 -35.36696 -4.17069  1.000 27.31648 ? 44  CYS A H    1 
ATOM   664  H HA   . CYS A 1 44  ? -18.60863 -34.81432 -6.59073  1.000 35.30033 ? 44  CYS A HA   1 
ATOM   665  H HB2  . CYS A 1 44  ? -17.85176 -33.07501 -4.49339  1.000 34.50833 ? 44  CYS A HB2  1 
ATOM   666  H HB3  . CYS A 1 44  ? -18.29969 -32.52849 -5.91721  1.000 34.50833 ? 44  CYS A HB3  1 
ATOM   667  H HG   . CYS A 1 44  ? -20.41854 -32.16614 -4.34674  1.000 32.30151 ? 44  CYS A HG   1 
ATOM   668  N N    . THR A 1 45  ? -16.63578 -34.06395 -7.87957  1.000 35.66695 ? 45  THR A N    1 
ATOM   669  C CA   . THR A 1 45  ? -15.47804 -33.45564 -8.50879  1.000 45.42551 ? 45  THR A CA   1 
ATOM   670  C C    . THR A 1 45  ? -15.42535 -31.97884 -8.11686  1.000 48.01749 ? 45  THR A C    1 
ATOM   671  O O    . THR A 1 45  ? -16.34700 -31.44496 -7.49486  1.000 45.45695 ? 45  THR A O    1 
ATOM   672  C CB   . THR A 1 45  ? -15.55940 -33.58477 -10.02490 1.000 41.72953 ? 45  THR A CB   1 
ATOM   673  O OG1  . THR A 1 45  ? -16.70679 -32.88139 -10.50887 1.000 42.90614 ? 45  THR A OG1  1 
ATOM   674  C CG2  . THR A 1 45  ? -15.71610 -35.05568 -10.38386 1.000 42.63112 ? 45  THR A CG2  1 
ATOM   675  H H    . THR A 1 45  ? -17.29847 -34.21916 -8.40690  1.000 42.80033 ? 45  THR A H    1 
ATOM   676  H HA   . THR A 1 45  ? -14.66879 -33.90118 -8.21578  1.000 54.51061 ? 45  THR A HA   1 
ATOM   677  H HB   . THR A 1 45  ? -14.75954 -33.22089 -10.43439 1.000 50.07544 ? 45  THR A HB   1 
ATOM   678  H HG1  . THR A 1 45  ? -16.64758 -32.77183 -11.33978 1.000 51.48737 ? 45  THR A HG1  1 
ATOM   679  H HG21 . THR A 1 45  ? -15.24366 -35.24679 -11.20981 1.000 51.15735 ? 45  THR A HG21 1 
ATOM   680  H HG22 . THR A 1 45  ? -15.35091 -35.61082 -9.67707  1.000 51.15735 ? 45  THR A HG22 1 
ATOM   681  H HG23 . THR A 1 45  ? -16.65389 -35.27135 -10.50032 1.000 51.15735 ? 45  THR A HG23 1 
ATOM   682  N N    . SER A 1 46  ? -14.34676 -31.29675 -8.50006  1.000 53.98695 ? 46  SER A N    1 
ATOM   683  C CA   . SER A 1 46  ? -14.30400 -29.86188 -8.22916  1.000 59.86637 ? 46  SER A CA   1 
ATOM   684  C C    . SER A 1 46  ? -15.32330 -29.10817 -9.07805  1.000 56.04394 ? 46  SER A C    1 
ATOM   685  O O    . SER A 1 46  ? -15.81728 -28.05682 -8.65158  1.000 49.59695 ? 46  SER A O    1 
ATOM   686  C CB   . SER A 1 46  ? -12.89936 -29.30262 -8.45332  1.000 64.28890 ? 46  SER A CB   1 
ATOM   687  O OG   . SER A 1 46  ? -11.92685 -30.18018 -7.91852  1.000 60.69031 ? 46  SER A OG   1 
ATOM   688  H H    . SER A 1 46  ? -13.66036 -31.62496 -8.90002  1.000 64.78433 ? 46  SER A H    1 
ATOM   689  H HA   . SER A 1 46  ? -14.51844 -29.71963 -7.29415  1.000 71.83965 ? 46  SER A HA   1 
ATOM   690  H HB2  . SER A 1 46  ? -12.74610 -29.20191 -9.40620  1.000 77.14668 ? 46  SER A HB2  1 
ATOM   691  H HB3  . SER A 1 46  ? -12.82620 -28.44184 -8.01176  1.000 77.14668 ? 46  SER A HB3  1 
ATOM   692  H HG   . SER A 1 46  ? -11.30956 -30.29834 -8.47637  1.000 72.82837 ? 46  SER A HG   1 
ATOM   693  N N    . GLU A 1 47  ? -15.65546 -29.63270 -10.26949 1.000 53.18109 ? 47  GLU A N    1 
ATOM   694  C CA   . GLU A 1 47  ? -16.69266 -29.01801 -11.09548 1.000 53.47703 ? 47  GLU A CA   1 
ATOM   695  C C    . GLU A 1 47  ? -18.06674 -29.19850 -10.46508 1.000 48.31644 ? 47  GLU A C    1 
ATOM   696  O O    . GLU A 1 47  ? -18.90544 -28.29213 -10.51681 1.000 46.36695 ? 47  GLU A O    1 
ATOM   697  C CB   . GLU A 1 47  ? -16.68868 -29.62014 -12.50585 1.000 56.96140 ? 47  GLU A CB   1 
ATOM   698  C CG   . GLU A 1 47  ? -17.11865 -28.65917 -13.61470 1.000 70.59409 ? 47  GLU A CG   1 
ATOM   699  C CD   . GLU A 1 47  ? -17.95964 -29.34064 -14.70743 1.000 78.17578 ? 47  GLU A CD   1 
ATOM   700  O OE1  . GLU A 1 47  ? -18.20370 -30.57089 -14.63931 1.000 80.69380 ? 47  GLU A OE1  1 
ATOM   701  O OE2  . GLU A 1 47  ? -18.38000 -28.63472 -15.64388 1.000 79.09091 ? 47  GLU A OE2  1 
ATOM   702  H H    . GLU A 1 47  ? -15.29778 -30.33420 -10.61380 1.000 63.81731 ? 47  GLU A H    1 
ATOM   703  H HA   . GLU A 1 47  ? -16.50038 -28.07081 -11.17083 1.000 64.17243 ? 47  GLU A HA   1 
ATOM   704  H HB2  . GLU A 1 47  ? -15.78856 -29.91712 -12.71031 1.000 68.35368 ? 47  GLU A HB2  1 
ATOM   705  H HB3  . GLU A 1 47  ? -17.29845 -30.37351 -12.52010 1.000 68.35368 ? 47  GLU A HB3  1 
ATOM   706  H HG2  . GLU A 1 47  ? -17.65298 -27.94828 -13.22642 1.000 84.71291 ? 47  GLU A HG2  1 
ATOM   707  H HG3  . GLU A 1 47  ? -16.32715 -28.28754 -14.03541 1.000 84.71291 ? 47  GLU A HG3  1 
ATOM   708  N N    . ASP A 1 48  ? -18.30901 -30.37206 -9.86689  1.000 45.77695 ? 48  ASP A N    1 
ATOM   709  C CA   . ASP A 1 48  ? -19.60498 -30.67946 -9.26953  1.000 41.28695 ? 48  ASP A CA   1 
ATOM   710  C C    . ASP A 1 48  ? -19.96014 -29.72845 -8.12807  1.000 38.09695 ? 48  ASP A C    1 
ATOM   711  O O    . ASP A 1 48  ? -21.14341 -29.51557 -7.83936  1.000 30.55695 ? 48  ASP A O    1 
ATOM   712  C CB   . ASP A 1 48  ? -19.61403 -32.11480 -8.73242  1.000 38.35695 ? 48  ASP A CB   1 
ATOM   713  C CG   . ASP A 1 48  ? -19.60779 -33.18513 -9.81808  1.000 44.51885 ? 48  ASP A CG   1 
ATOM   714  O OD1  . ASP A 1 48  ? -20.09658 -32.94682 -10.94811 1.000 41.73695 ? 48  ASP A OD1  1 
ATOM   715  O OD2  . ASP A 1 48  ? -19.12102 -34.29493 -9.50459  1.000 41.37717 ? 48  ASP A OD2  1 
ATOM   716  H H    . ASP A 1 48  ? -17.73453 -31.00865 -9.79508  1.000 54.93233 ? 48  ASP A H    1 
ATOM   717  H HA   . ASP A 1 48  ? -20.27480 -30.59056 -9.96572  1.000 49.54433 ? 48  ASP A HA   1 
ATOM   718  H HB2  . ASP A 1 48  ? -18.82512 -32.24651 -8.18322  1.000 46.02833 ? 48  ASP A HB2  1 
ATOM   719  H HB3  . ASP A 1 48  ? -20.41411 -32.24176 -8.19878  1.000 46.02833 ? 48  ASP A HB3  1 
ATOM   720  N N    . MET A 1 49  ? -18.95582 -29.17006 -7.45137  1.000 41.65695 ? 49  MET A N    1 
ATOM   721  C CA   . MET A 1 49  ? -19.22886 -28.40803 -6.24000  1.000 41.89695 ? 49  MET A CA   1 
ATOM   722  C C    . MET A 1 49  ? -19.88482 -27.07237 -6.53141  1.000 38.50695 ? 49  MET A C    1 
ATOM   723  O O    . MET A 1 49  ? -20.38166 -26.42734 -5.60218  1.000 33.39695 ? 49  MET A O    1 
ATOM   724  C CB   . MET A 1 49  ? -17.94633 -28.17350 -5.43240  1.000 46.33695 ? 49  MET A CB   1 
ATOM   725  C CG   . MET A 1 49  ? -17.33578 -29.45256 -4.92763  1.000 53.32774 ? 49  MET A CG   1 
ATOM   726  S SD   . MET A 1 49  ? -18.33786 -30.24447 -3.65657  1.000 93.42695 ? 49  MET A SD   1 
ATOM   727  C CE   . MET A 1 49  ? -18.98450 -28.82035 -2.76017  1.000 36.52695 ? 49  MET A CE   1 
ATOM   728  H H    . MET A 1 49  ? -18.12571 -29.21827 -7.67011  1.000 49.98833 ? 49  MET A H    1 
ATOM   729  H HA   . MET A 1 49  ? -19.81863 -28.94284 -5.68654  1.000 50.27633 ? 49  MET A HA   1 
ATOM   730  H HB2  . MET A 1 49  ? -17.29421 -27.73077 -5.99728  1.000 55.60433 ? 49  MET A HB2  1 
ATOM   731  H HB3  . MET A 1 49  ? -18.15445 -27.61685 -4.66599  1.000 55.60433 ? 49  MET A HB3  1 
ATOM   732  H HG2  . MET A 1 49  ? -17.24386 -30.07325 -5.66734  1.000 63.99329 ? 49  MET A HG2  1 
ATOM   733  H HG3  . MET A 1 49  ? -16.46448 -29.25867 -4.54748  1.000 63.99329 ? 49  MET A HG3  1 
ATOM   734  H HE1  . MET A 1 49  ? -19.54996 -29.13215 -2.03720  1.000 43.83233 ? 49  MET A HE1  1 
ATOM   735  H HE2  . MET A 1 49  ? -18.24153 -28.30844 -2.40249  1.000 43.83233 ? 49  MET A HE2  1 
ATOM   736  H HE3  . MET A 1 49  ? -19.50087 -28.27089 -3.37101  1.000 43.83233 ? 49  MET A HE3  1 
ATOM   737  N N    . LEU A 1 50  ? -19.90672 -26.63761 -7.78615  1.000 35.66695 ? 50  LEU A N    1 
ATOM   738  C CA   . LEU A 1 50  ? -20.59561 -25.38998 -8.08462  1.000 37.63677 ? 50  LEU A CA   1 
ATOM   739  C C    . LEU A 1 50  ? -22.09756 -25.54129 -7.88624  1.000 37.06695 ? 50  LEU A C    1 
ATOM   740  O O    . LEU A 1 50  ? -22.77245 -24.58606 -7.50789  1.000 35.84695 ? 50  LEU A O    1 
ATOM   741  C CB   . LEU A 1 50  ? -20.34247 -24.92589 -9.51525  1.000 37.37695 ? 50  LEU A CB   1 
ATOM   742  C CG   . LEU A 1 50  ? -19.03901 -24.15873 -9.72231  1.000 44.76941 ? 50  LEU A CG   1 
ATOM   743  C CD1  . LEU A 1 50  ? -18.78221 -23.10215 -8.70457  1.000 40.19454 ? 50  LEU A CD1  1 
ATOM   744  C CD2  . LEU A 1 50  ? -17.89016 -25.19377 -9.78755  1.000 52.12423 ? 50  LEU A CD2  1 
ATOM   745  H H    . LEU A 1 50  ? -19.54317 -27.03091 -8.45926  1.000 42.80033 ? 50  LEU A H    1 
ATOM   746  H HA   . LEU A 1 50  ? -20.24136 -24.71306 -7.48708  1.000 45.16412 ? 50  LEU A HA   1 
ATOM   747  H HB2  . LEU A 1 50  ? -20.31565 -25.70652 -10.08972 1.000 44.85233 ? 50  LEU A HB2  1 
ATOM   748  H HB3  . LEU A 1 50  ? -21.06984 -24.34131 -9.78114  1.000 44.85233 ? 50  LEU A HB3  1 
ATOM   749  H HG   . LEU A 1 50  ? -19.09411 -23.66026 -10.55303 1.000 53.72329 ? 50  LEU A HG   1 
ATOM   750  H HD11 . LEU A 1 50  ? -17.96650 -22.63136 -8.93699  1.000 48.23344 ? 50  LEU A HD11 1 
ATOM   751  H HD12 . LEU A 1 50  ? -19.52971 -22.48375 -8.69645  1.000 48.23344 ? 50  LEU A HD12 1 
ATOM   752  H HD13 . LEU A 1 50  ? -18.68819 -23.51861 -7.83379  1.000 48.23344 ? 50  LEU A HD13 1 
ATOM   753  H HD21 . LEU A 1 50  ? -17.05547 -24.73000 -9.95497  1.000 62.54907 ? 50  LEU A HD21 1 
ATOM   754  H HD22 . LEU A 1 50  ? -17.84209 -25.66626 -8.94082  1.000 62.54907 ? 50  LEU A HD22 1 
ATOM   755  H HD23 . LEU A 1 50  ? -18.07041 -25.82147 -10.50600 1.000 62.54907 ? 50  LEU A HD23 1 
ATOM   756  N N    . ASN A 1 51  ? -22.63953 -26.72156 -8.14916  1.000 35.51695 ? 51  ASN A N    1 
ATOM   757  C CA   . ASN A 1 51  ? -24.07239 -26.93476 -8.05880  1.000 36.27695 ? 51  ASN A CA   1 
ATOM   758  C C    . ASN A 1 51  ? -24.35521 -28.42400 -8.03882  1.000 30.02695 ? 51  ASN A C    1 
ATOM   759  O O    . ASN A 1 51  ? -24.85343 -28.96679 -9.02233  1.000 28.93346 ? 51  ASN A O    1 
ATOM   760  C CB   . ASN A 1 51  ? -24.79354 -26.23162 -9.21562  1.000 40.29811 ? 51  ASN A CB   1 
ATOM   761  C CG   . ASN A 1 51  ? -26.29761 -26.22894 -9.02215  1.000 50.30744 ? 51  ASN A CG   1 
ATOM   762  O OD1  . ASN A 1 51  ? -26.78829 -25.85599 -7.95309  1.000 47.63953 ? 51  ASN A OD1  1 
ATOM   763  N ND2  . ASN A 1 51  ? -27.03798 -26.55988 -10.07962 1.000 49.38480 ? 51  ASN A ND2  1 
ATOM   764  H H    . ASN A 1 51  ? -22.19389 -27.41907 -8.38344  1.000 42.62033 ? 51  ASN A H    1 
ATOM   765  H HA   . ASN A 1 51  ? -24.41898 -26.55654 -7.23569  1.000 43.53233 ? 51  ASN A HA   1 
ATOM   766  H HB2  . ASN A 1 51  ? -24.49225 -25.31135 -9.26795  1.000 48.35773 ? 51  ASN A HB2  1 
ATOM   767  H HB3  . ASN A 1 51  ? -24.59488 -26.69395 -10.04484 1.000 48.35773 ? 51  ASN A HB3  1 
ATOM   768  H HD21 . ASN A 1 51  ? -26.65755 -26.76111 -10.82461 1.000 59.26176 ? 51  ASN A HD21 1 
ATOM   769  H HD22 . ASN A 1 51  ? -27.89499 -26.57260 -10.01793 1.000 59.26176 ? 51  ASN A HD22 1 
ATOM   770  N N    . PRO A 1 52  ? -24.03204 -29.12141 -6.95413  1.000 27.86695 ? 52  PRO A N    1 
ATOM   771  C CA   . PRO A 1 52  ? -24.18287 -30.58653 -6.95609  1.000 24.82071 ? 52  PRO A CA   1 
ATOM   772  C C    . PRO A 1 52  ? -25.61361 -31.02583 -6.70187  1.000 24.54333 ? 52  PRO A C    1 
ATOM   773  O O    . PRO A 1 52  ? -26.34837 -30.42189 -5.92175  1.000 24.27925 ? 52  PRO A O    1 
ATOM   774  C CB   . PRO A 1 52  ? -23.25090 -31.04648 -5.82805  1.000 30.49199 ? 52  PRO A CB   1 
ATOM   775  C CG   . PRO A 1 52  ? -23.21818 -29.86104 -4.87830  1.000 26.14149 ? 52  PRO A CG   1 
ATOM   776  C CD   . PRO A 1 52  ? -23.39788 -28.61467 -5.71760  1.000 29.91695 ? 52  PRO A CD   1 
ATOM   777  H HA   . PRO A 1 52  ? -23.88328 -30.95277 -7.80321  1.000 29.78486 ? 52  PRO A HA   1 
ATOM   778  H HB2  . PRO A 1 52  ? -23.61443 -31.83404 -5.39366  1.000 36.59039 ? 52  PRO A HB2  1 
ATOM   779  H HB3  . PRO A 1 52  ? -22.36763 -31.23956 -6.17985  1.000 36.59039 ? 52  PRO A HB3  1 
ATOM   780  H HG2  . PRO A 1 52  ? -23.93935 -29.94301 -4.23461  1.000 31.36979 ? 52  PRO A HG2  1 
ATOM   781  H HG3  . PRO A 1 52  ? -22.36436 -29.83965 -4.41899  1.000 31.36979 ? 52  PRO A HG3  1 
ATOM   782  H HD2  . PRO A 1 52  ? -23.97754 -27.97841 -5.26941  1.000 35.90033 ? 52  PRO A HD2  1 
ATOM   783  H HD3  . PRO A 1 52  ? -22.54114 -28.20387 -5.91204  1.000 35.90033 ? 52  PRO A HD3  1 
ATOM   784  N N    . ASN A 1 53  ? -26.00252 -32.09171 -7.39366  1.000 24.98489 ? 53  ASN A N    1 
ATOM   785  C CA   . ASN A 1 53  ? -27.23204 -32.82086 -7.10954  1.000 28.38073 ? 53  ASN A CA   1 
ATOM   786  C C    . ASN A 1 53  ? -26.76228 -34.08692 -6.41516  1.000 23.84811 ? 53  ASN A C    1 
ATOM   787  O O    . ASN A 1 53  ? -26.39027 -35.07323 -7.05564  1.000 21.74485 ? 53  ASN A O    1 
ATOM   788  C CB   . ASN A 1 53  ? -28.01835 -33.12471 -8.37901  1.000 28.14663 ? 53  ASN A CB   1 
ATOM   789  C CG   . ASN A 1 53  ? -29.32391 -33.80592 -8.09689  1.000 30.17957 ? 53  ASN A CG   1 
ATOM   790  O OD1  . ASN A 1 53  ? -29.39635 -34.81742 -7.39154  1.000 29.90496 ? 53  ASN A OD1  1 
ATOM   791  N ND2  . ASN A 1 53  ? -30.40117 -33.23845 -8.63692  1.000 37.07245 ? 53  ASN A ND2  1 
ATOM   792  H H    . ASN A 1 53  ? -25.55803 -32.42095 -8.05071  1.000 29.98186 ? 53  ASN A H    1 
ATOM   793  H HA   . ASN A 1 53  ? -27.82066 -32.30369 -6.53743  1.000 34.05688 ? 53  ASN A HA   1 
ATOM   794  H HB2  . ASN A 1 53  ? -28.20685 -32.29357 -8.84256  1.000 33.77596 ? 53  ASN A HB2  1 
ATOM   795  H HB3  . ASN A 1 53  ? -27.49169 -33.70894 -8.94718  1.000 33.77596 ? 53  ASN A HB3  1 
ATOM   796  H HD21 . ASN A 1 53  ? -31.17794 -33.58414 -8.51041  1.000 44.48694 ? 53  ASN A HD21 1 
ATOM   797  H HD22 . ASN A 1 53  ? -30.31857 -32.52709 -9.11345  1.000 44.48694 ? 53  ASN A HD22 1 
ATOM   798  N N    . TYR A 1 54  ? -26.68480 -34.02868 -5.08210  1.000 24.41778 ? 54  TYR A N    1 
ATOM   799  C CA   . TYR A 1 54  ? -26.04917 -35.12361 -4.37555  1.000 24.33741 ? 54  TYR A CA   1 
ATOM   800  C C    . TYR A 1 54  ? -26.78205 -36.44407 -4.57862  1.000 21.81100 ? 54  TYR A C    1 
ATOM   801  O O    . TYR A 1 54  ? -26.14519 -37.48450 -4.67904  1.000 22.82860 ? 54  TYR A O    1 
ATOM   802  C CB   . TYR A 1 54  ? -25.94497 -34.78143 -2.90330  1.000 23.05609 ? 54  TYR A CB   1 
ATOM   803  C CG   . TYR A 1 54  ? -24.82283 -33.81471 -2.62731  1.000 20.44610 ? 54  TYR A CG   1 
ATOM   804  C CD1  . TYR A 1 54  ? -23.50549 -34.25768 -2.59511  1.000 18.72853 ? 54  TYR A CD1  1 
ATOM   805  C CD2  . TYR A 1 54  ? -25.08298 -32.48507 -2.37658  1.000 21.62179 ? 54  TYR A CD2  1 
ATOM   806  C CE1  . TYR A 1 54  ? -22.47529 -33.37804 -2.30921  1.000 17.24309 ? 54  TYR A CE1  1 
ATOM   807  C CE2  . TYR A 1 54  ? -24.05879 -31.59543 -2.09367  1.000 18.91552 ? 54  TYR A CE2  1 
ATOM   808  C CZ   . TYR A 1 54  ? -22.75643 -32.05440 -2.08149  1.000 20.91586 ? 54  TYR A CZ   1 
ATOM   809  O OH   . TYR A 1 54  ? -21.72721 -31.19074 -1.81560  1.000 18.84026 ? 54  TYR A OH   1 
ATOM   810  H H    . TYR A 1 54  ? -26.98148 -33.38922 -4.58981  1.000 29.30134 ? 54  TYR A H    1 
ATOM   811  H HA   . TYR A 1 54  ? -25.15195 -35.24468 -4.72430  1.000 29.20490 ? 54  TYR A HA   1 
ATOM   812  H HB2  . TYR A 1 54  ? -26.77539 -34.37427 -2.61134  1.000 27.66731 ? 54  TYR A HB2  1 
ATOM   813  H HB3  . TYR A 1 54  ? -25.77750 -35.59261 -2.39874  1.000 27.66731 ? 54  TYR A HB3  1 
ATOM   814  H HD1  . TYR A 1 54  ? -23.31572 -35.15142 -2.76760  1.000 22.47424 ? 54  TYR A HD1  1 
ATOM   815  H HD2  . TYR A 1 54  ? -25.96122 -32.17976 -2.39670  1.000 25.94615 ? 54  TYR A HD2  1 
ATOM   816  H HE1  . TYR A 1 54  ? -21.59706 -33.68236 -2.27209  1.000 20.69171 ? 54  TYR A HE1  1 
ATOM   817  H HE2  . TYR A 1 54  ? -24.24556 -30.70269 -1.91418  1.000 22.69863 ? 54  TYR A HE2  1 
ATOM   818  H HH   . TYR A 1 54  ? -22.02086 -30.40602 -1.74922  1.000 22.60832 ? 54  TYR A HH   1 
ATOM   819  N N    . GLU A 1 55  ? -28.10504 -36.41306 -4.68507  1.000 24.84033 ? 55  GLU A N    1 
ATOM   820  C CA   . GLU A 1 55  ? -28.83698 -37.65752 -4.88209  1.000 25.51057 ? 55  GLU A CA   1 
ATOM   821  C C    . GLU A 1 55  ? -28.37798 -38.33635 -6.17835  1.000 19.95248 ? 55  GLU A C    1 
ATOM   822  O O    . GLU A 1 55  ? -27.98204 -39.51304 -6.18394  1.000 27.76083 ? 55  GLU A O    1 
ATOM   823  C CB   . GLU A 1 55  ? -30.34717 -37.40971 -4.89347  1.000 28.14844 ? 55  GLU A CB   1 
ATOM   824  C CG   . GLU A 1 55  ? -30.90559 -36.75254 -3.59214  1.000 33.24343 ? 55  GLU A CG   1 
ATOM   825  C CD   . GLU A 1 55  ? -30.42643 -35.30950 -3.25409  1.000 33.84076 ? 55  GLU A CD   1 
ATOM   826  O OE1  . GLU A 1 55  ? -29.82904 -34.56885 -4.08043  1.000 42.23794 ? 55  GLU A OE1  1 
ATOM   827  O OE2  . GLU A 1 55  ? -30.60571 -34.92151 -2.09126  1.000 47.51202 ? 55  GLU A OE2  1 
ATOM   828  H H    . GLU A 1 55  ? -28.59062 -35.70446 -4.64880  1.000 29.80840 ? 55  GLU A H    1 
ATOM   829  H HA   . GLU A 1 55  ? -28.65677 -38.25183 -4.13640  1.000 30.61268 ? 55  GLU A HA   1 
ATOM   830  H HB2  . GLU A 1 55  ? -30.55815 -36.81896 -5.63308  1.000 33.77813 ? 55  GLU A HB2  1 
ATOM   831  H HB3  . GLU A 1 55  ? -30.79941 -38.26079 -5.00799  1.000 33.77813 ? 55  GLU A HB3  1 
ATOM   832  H HG2  . GLU A 1 55  ? -31.87186 -36.71508 -3.66874  1.000 39.89211 ? 55  GLU A HG2  1 
ATOM   833  H HG3  . GLU A 1 55  ? -30.65284 -37.31345 -2.84235  1.000 39.89211 ? 55  GLU A HG3  1 
ATOM   834  N N    . ASP A 1 56  ? -28.39118 -37.59068 -7.28889  1.000 27.12172 ? 56  ASP A N    1 
ATOM   835  C CA   . ASP A 1 56  ? -27.92630 -38.13252 -8.56707  1.000 24.80464 ? 56  ASP A CA   1 
ATOM   836  C C    . ASP A 1 56  ? -26.47497 -38.56540 -8.51282  1.000 31.37767 ? 56  ASP A C    1 
ATOM   837  O O    . ASP A 1 56  ? -26.10195 -39.58975 -9.09332  1.000 26.12780 ? 56  ASP A O    1 
ATOM   838  C CB   . ASP A 1 56  ? -28.09874 -37.08398 -9.66648  1.000 27.63412 ? 56  ASP A CB   1 
ATOM   839  C CG   . ASP A 1 56  ? -29.54075 -36.87886 -10.11086 1.000 32.69028 ? 56  ASP A CG   1 
ATOM   840  O OD1  . ASP A 1 56  ? -30.51055 -37.40601 -9.49753  1.000 33.15732 ? 56  ASP A OD1  1 
ATOM   841  O OD2  . ASP A 1 56  ? -29.68304 -36.08838 -11.06843 1.000 36.66329 ? 56  ASP A OD2  1 
ATOM   842  H H    . ASP A 1 56  ? -28.66182 -36.77587 -7.32849  1.000 32.54607 ? 56  ASP A H    1 
ATOM   843  H HA   . ASP A 1 56  ? -28.46661 -38.91082 -8.77474  1.000 29.76557 ? 56  ASP A HA   1 
ATOM   844  H HB2  . ASP A 1 56  ? -27.76854 -36.23292 -9.33884  1.000 33.16095 ? 56  ASP A HB2  1 
ATOM   845  H HB3  . ASP A 1 56  ? -27.58825 -37.36110 -10.44347 1.000 33.16095 ? 56  ASP A HB3  1 
ATOM   846  N N    . LEU A 1 57  ? -25.62184 -37.76112 -7.86902  1.000 29.80076 ? 57  LEU A N    1 
ATOM   847  C CA   . LEU A 1 57  ? -24.20758 -38.09901 -7.84373  1.000 30.93646 ? 57  LEU A CA   1 
ATOM   848  C C    . LEU A 1 57  ? -23.97985 -39.36932 -7.04443  1.000 25.84653 ? 57  LEU A C    1 
ATOM   849  O O    . LEU A 1 57  ? -23.12608 -40.17742 -7.40563  1.000 32.75823 ? 57  LEU A O    1 
ATOM   850  C CB   . LEU A 1 57  ? -23.39370 -36.95072 -7.25274  1.000 23.30170 ? 57  LEU A CB   1 
ATOM   851  C CG   . LEU A 1 57  ? -23.31136 -35.72810 -8.15395  1.000 27.79756 ? 57  LEU A CG   1 
ATOM   852  C CD1  . LEU A 1 57  ? -22.66055 -34.55404 -7.41600  1.000 25.50506 ? 57  LEU A CD1  1 
ATOM   853  C CD2  . LEU A 1 57  ? -22.54370 -35.98870 -9.43184  1.000 28.56570 ? 57  LEU A CD2  1 
ATOM   854  H H    . LEU A 1 57  ? -25.83456 -37.03854 -7.45465  1.000 35.76091 ? 57  LEU A H    1 
ATOM   855  H HA   . LEU A 1 57  ? -23.89715 -38.23620 -8.75271  1.000 37.12375 ? 57  LEU A HA   1 
ATOM   856  H HB2  . LEU A 1 57  ? -23.80422 -36.67656 -6.41771  1.000 27.96205 ? 57  LEU A HB2  1 
ATOM   857  H HB3  . LEU A 1 57  ? -22.48951 -37.26210 -7.09161  1.000 27.96205 ? 57  LEU A HB3  1 
ATOM   858  H HG   . LEU A 1 57  ? -24.22245 -35.50168 -8.39914  1.000 33.35708 ? 57  LEU A HG   1 
ATOM   859  H HD11 . LEU A 1 57  ? -22.62495 -33.78864 -8.00952  1.000 30.60608 ? 57  LEU A HD11 1 
ATOM   860  H HD12 . LEU A 1 57  ? -23.19100 -34.34094 -6.63206  1.000 30.60608 ? 57  LEU A HD12 1 
ATOM   861  H HD13 . LEU A 1 57  ? -21.76344 -34.80749 -7.14884  1.000 30.60608 ? 57  LEU A HD13 1 
ATOM   862  H HD21 . LEU A 1 57  ? -22.35522 -35.14228 -9.86626  1.000 34.27885 ? 57  LEU A HD21 1 
ATOM   863  H HD22 . LEU A 1 57  ? -21.71341 -36.44118 -9.21483  1.000 34.27885 ? 57  LEU A HD22 1 
ATOM   864  H HD23 . LEU A 1 57  ? -23.08205 -36.54777 -10.01538 1.000 34.27885 ? 57  LEU A HD23 1 
ATOM   865  N N    . LEU A 1 58  ? -24.75305 -39.58959 -5.97984  1.000 31.02135 ? 58  LEU A N    1 
ATOM   866  C CA   . LEU A 1 58  ? -24.52340 -40.76591 -5.17149  1.000 26.49219 ? 58  LEU A CA   1 
ATOM   867  C C    . LEU A 1 58  ? -25.07517 -42.00592 -5.86745  1.000 27.31873 ? 58  LEU A C    1 
ATOM   868  O O    . LEU A 1 58  ? -24.51835 -43.09256 -5.72992  1.000 29.85185 ? 58  LEU A O    1 
ATOM   869  C CB   . LEU A 1 58  ? -25.18200 -40.62228 -3.80163  1.000 28.23128 ? 58  LEU A CB   1 
ATOM   870  C CG   . LEU A 1 58  ? -24.93154 -41.67773 -2.73919  1.000 29.46037 ? 58  LEU A CG   1 
ATOM   871  C CD1  . LEU A 1 58  ? -23.48650 -41.87279 -2.40380  1.000 25.58855 ? 58  LEU A CD1  1 
ATOM   872  C CD2  . LEU A 1 58  ? -25.74331 -41.25313 -1.51222  1.000 28.14887 ? 58  LEU A CD2  1 
ATOM   873  H H    . LEU A 1 58  ? -25.39755 -39.08327 -5.71776  1.000 37.22563 ? 58  LEU A H    1 
ATOM   874  H HA   . LEU A 1 58  ? -23.56937 -40.86523 -5.03221  1.000 31.79063 ? 58  LEU A HA   1 
ATOM   875  H HB2  . LEU A 1 58  ? -24.88380 -39.78027 -3.42501  1.000 33.87753 ? 58  LEU A HB2  1 
ATOM   876  H HB3  . LEU A 1 58  ? -26.14197 -40.60195 -3.94296  1.000 33.87753 ? 58  LEU A HB3  1 
ATOM   877  H HG   . LEU A 1 58  ? -25.20673 -42.54875 -3.06683  1.000 35.35245 ? 58  LEU A HG   1 
ATOM   878  H HD11 . LEU A 1 58  ? -23.41941 -42.35325 -1.56408  1.000 30.70626 ? 58  LEU A HD11 1 
ATOM   879  H HD12 . LEU A 1 58  ? -23.06384 -42.38301 -3.11197  1.000 30.70626 ? 58  LEU A HD12 1 
ATOM   880  H HD13 . LEU A 1 58  ? -23.06222 -41.00450 -2.32312  1.000 30.70626 ? 58  LEU A HD13 1 
ATOM   881  H HD21 . LEU A 1 58  ? -26.05684 -42.04767 -1.05182  1.000 33.77864 ? 58  LEU A HD21 1 
ATOM   882  H HD22 . LEU A 1 58  ? -25.17593 -40.73104 -0.92369  1.000 33.77864 ? 58  LEU A HD22 1 
ATOM   883  H HD23 . LEU A 1 58  ? -26.49863 -40.71956 -1.80315  1.000 33.77864 ? 58  LEU A HD23 1 
ATOM   884  N N    . ILE A 1 59  ? -26.16102 -41.85431 -6.62674  1.000 31.26998 ? 59  ILE A N    1 
ATOM   885  C CA   . ILE A 1 59  ? -26.75487 -42.99937 -7.31165  1.000 29.06011 ? 59  ILE A CA   1 
ATOM   886  C C    . ILE A 1 59  ? -25.73604 -43.61296 -8.27267  1.000 27.86132 ? 59  ILE A C    1 
ATOM   887  O O    . ILE A 1 59  ? -25.71699 -44.83481 -8.49642  1.000 40.62704 ? 59  ILE A O    1 
ATOM   888  C CB   . ILE A 1 59  ? -28.05100 -42.52698 -7.99482  1.000 25.66295 ? 59  ILE A CB   1 
ATOM   889  C CG1  . ILE A 1 59  ? -29.16536 -42.54150 -6.95422  1.000 31.77725 ? 59  ILE A CG1  1 
ATOM   890  C CG2  . ILE A 1 59  ? -28.36986 -43.43950 -9.17749  1.000 35.60405 ? 59  ILE A CG2  1 
ATOM   891  C CD1  . ILE A 1 59  ? -30.46462 -42.00425 -7.42435  1.000 38.27423 ? 59  ILE A CD1  1 
ATOM   892  H H    . ILE A 1 59  ? -26.56757 -41.10856 -6.76042  1.000 37.52398 ? 59  ILE A H    1 
ATOM   893  H HA   . ILE A 1 59  ? -26.99453 -43.70294 -6.68717  1.000 34.87213 ? 59  ILE A HA   1 
ATOM   894  H HB   . ILE A 1 59  ? -27.95360 -41.62569 -8.34023  1.000 30.79553 ? 59  ILE A HB   1 
ATOM   895  H HG12 . ILE A 1 59  ? -29.31273 -43.45879 -6.67484  1.000 38.13271 ? 59  ILE A HG12 1 
ATOM   896  H HG13 . ILE A 1 59  ? -28.88505 -42.00475 -6.19679  1.000 38.13271 ? 59  ILE A HG13 1 
ATOM   897  H HG21 . ILE A 1 59  ? -29.27989 -43.27205 -9.46971  1.000 42.72485 ? 59  ILE A HG21 1 
ATOM   898  H HG22 . ILE A 1 59  ? -27.74976 -43.24956 -9.89816  1.000 42.72485 ? 59  ILE A HG22 1 
ATOM   899  H HG23 . ILE A 1 59  ? -28.27822 -44.36360 -8.89703  1.000 42.72485 ? 59  ILE A HG23 1 
ATOM   900  H HD11 . ILE A 1 59  ? -31.01806 -41.79716 -6.65542  1.000 45.92908 ? 59  ILE A HD11 1 
ATOM   901  H HD12 . ILE A 1 59  ? -30.30508 -41.19980 -7.94280  1.000 45.92908 ? 59  ILE A HD12 1 
ATOM   902  H HD13 . ILE A 1 59  ? -30.90190 -42.67126 -7.97591  1.000 45.92908 ? 59  ILE A HD13 1 
ATOM   903  N N    . ARG A 1 60  ? -24.82449 -42.81292 -8.78786  1.000 26.60536 ? 60  ARG A N    1 
ATOM   904  C CA   . ARG A 1 60  ? -23.76276 -43.36356 -9.61382  1.000 30.84033 ? 60  ARG A CA   1 
ATOM   905  C C    . ARG A 1 60  ? -22.66248 -44.07018 -8.81787  1.000 37.68361 ? 60  ARG A C    1 
ATOM   906  O O    . ARG A 1 60  ? -21.70887 -44.57104 -9.43384  1.000 36.75479 ? 60  ARG A O    1 
ATOM   907  C CB   . ARG A 1 60  ? -23.14933 -42.26855 -10.47393 1.000 24.50384 ? 60  ARG A CB   1 
ATOM   908  H H    . ARG A 1 60  ? -24.79721 -41.95996 -8.67832  1.000 31.92644 ? 60  ARG A H    1 
ATOM   909  H HA   . ARG A 1 60  ? -24.15603 -44.02651 -10.20337 1.000 37.00839 ? 60  ARG A HA   1 
ATOM   910  N N    . LYS A 1 61  ? -22.73490 -44.13306 -7.48093  1.000 36.07852 ? 61  LYS A N    1 
ATOM   911  C CA   . LYS A 1 61  ? -21.70064 -44.80971 -6.71598  1.000 32.12560 ? 61  LYS A CA   1 
ATOM   912  C C    . LYS A 1 61  ? -22.23781 -46.10850 -6.12798  1.000 35.48321 ? 61  LYS A C    1 
ATOM   913  O O    . LYS A 1 61  ? -23.41486 -46.20266 -5.76345  1.000 36.30604 ? 61  LYS A O    1 
ATOM   914  C CB   . LYS A 1 61  ? -21.16073 -43.95200 -5.55327  1.000 27.58971 ? 61  LYS A CB   1 
ATOM   915  C CG   . LYS A 1 61  ? -20.71168 -42.57639 -5.95726  1.000 27.96693 ? 61  LYS A CG   1 
ATOM   916  C CD   . LYS A 1 61  ? -19.38840 -42.61489 -6.67482  1.000 29.50007 ? 61  LYS A CD   1 
ATOM   917  C CE   . LYS A 1 61  ? -19.10629 -41.23732 -7.23987  1.000 34.00639 ? 61  LYS A CE   1 
ATOM   918  N NZ   . LYS A 1 61  ? -17.83305 -41.20384 -7.99140  1.000 31.45245 ? 61  LYS A NZ   1 
ATOM   919  H H    . LYS A 1 61  ? -23.36934 -43.79286 -7.00895  1.000 43.29423 ? 61  LYS A H    1 
ATOM   920  H HA   . LYS A 1 61  ? -20.96827 -44.99975 -7.32284  1.000 38.55072 ? 61  LYS A HA   1 
ATOM   921  H HB2  . LYS A 1 61  ? -21.86304 -43.84996 -4.89145  1.000 33.10765 ? 61  LYS A HB2  1 
ATOM   922  H HB3  . LYS A 1 61  ? -20.39851 -44.40663 -5.16128  1.000 33.10765 ? 61  LYS A HB3  1 
ATOM   923  H HG2  . LYS A 1 61  ? -21.36978 -42.18554 -6.55325  1.000 33.56032 ? 61  LYS A HG2  1 
ATOM   924  H HG3  . LYS A 1 61  ? -20.61340 -42.02480 -5.16488  1.000 33.56032 ? 61  LYS A HG3  1 
ATOM   925  H HD2  . LYS A 1 61  ? -18.68142 -42.85471 -6.05471  1.000 35.40008 ? 61  LYS A HD2  1 
ATOM   926  H HD3  . LYS A 1 61  ? -19.42263 -43.25547 -7.40222  1.000 35.40008 ? 61  LYS A HD3  1 
ATOM   927  H HE2  . LYS A 1 61  ? -19.82328 -40.98652 -7.84397  1.000 40.80767 ? 61  LYS A HE2  1 
ATOM   928  H HE3  . LYS A 1 61  ? -19.04706 -40.59872 -6.51145  1.000 40.80767 ? 61  LYS A HE3  1 
ATOM   929  H HZ1  . LYS A 1 61  ? -17.57468 -40.36156 -8.11579  1.000 37.74294 ? 61  LYS A HZ1  1 
ATOM   930  H HZ2  . LYS A 1 61  ? -17.19987 -41.63562 -7.53744  1.000 37.74294 ? 61  LYS A HZ2  1 
ATOM   931  H HZ3  . LYS A 1 61  ? -17.93646 -41.59444 -8.78467  1.000 37.74294 ? 61  LYS A HZ3  1 
ATOM   932  N N    . SER A 1 62  ? -21.34808 -47.08487 -6.00326  1.000 35.30859 ? 62  SER A N    1 
ATOM   933  C CA   . SER A 1 62  ? -21.60731 -48.34849 -5.33513  1.000 32.26955 ? 62  SER A CA   1 
ATOM   934  C C    . SER A 1 62  ? -20.67365 -48.45349 -4.13187  1.000 31.45243 ? 62  SER A C    1 
ATOM   935  O O    . SER A 1 62  ? -19.71530 -47.68881 -3.99706  1.000 34.36311 ? 62  SER A O    1 
ATOM   936  C CB   . SER A 1 62  ? -21.38203 -49.53473 -6.28279  1.000 36.30830 ? 62  SER A CB   1 
ATOM   937  O OG   . SER A 1 62  ? -22.29168 -49.48478 -7.36708  1.000 29.13940 ? 62  SER A OG   1 
ATOM   938  H H    . SER A 1 62  ? -20.54701 -47.03404 -6.31395  1.000 42.37030 ? 62  SER A H    1 
ATOM   939  H HA   . SER A 1 62  ? -22.52939 -48.38241 -5.03448  1.000 38.72346 ? 62  SER A HA   1 
ATOM   940  H HB2  . SER A 1 62  ? -20.47593 -49.49779 -6.62744  1.000 43.56995 ? 62  SER A HB2  1 
ATOM   941  H HB3  . SER A 1 62  ? -21.51754 -50.36113 -5.79334  1.000 43.56995 ? 62  SER A HB3  1 
ATOM   942  H HG   . SER A 1 62  ? -22.02707 -49.98519 -7.98829  1.000 34.96728 ? 62  SER A HG   1 
ATOM   943  N N    . ASN A 1 63  ? -20.96719 -49.41926 -3.25957  1.000 32.43334 ? 63  ASN A N    1 
ATOM   944  C CA   . ASN A 1 63  ? -20.11539 -49.67530 -2.09742  1.000 29.71584 ? 63  ASN A CA   1 
ATOM   945  C C    . ASN A 1 63  ? -18.64221 -49.74890 -2.45995  1.000 31.75535 ? 63  ASN A C    1 
ATOM   946  O O    . ASN A 1 63  ? -17.79286 -49.27270 -1.69236  1.000 32.24360 ? 63  ASN A O    1 
ATOM   947  C CB   . ASN A 1 63  ? -20.54459 -50.98505 -1.43438  1.000 27.49157 ? 63  ASN A CB   1 
ATOM   948  C CG   . ASN A 1 63  ? -21.90589 -50.91056 -0.74482  1.000 41.69265 ? 63  ASN A CG   1 
ATOM   949  O OD1  . ASN A 1 63  ? -22.45883 -49.84616 -0.47936  1.000 30.99031 ? 63  ASN A OD1  1 
ATOM   950  N ND2  . ASN A 1 63  ? -22.48204 -52.08015 -0.52774  1.000 34.76570 ? 63  ASN A ND2  1 
ATOM   951  H H    . ASN A 1 63  ? -21.64975 -49.93777 -3.31713  1.000 38.92001 ? 63  ASN A H    1 
ATOM   952  H HA   . ASN A 1 63  ? -20.22920 -48.94177 -1.47401  1.000 35.65900 ? 63  ASN A HA   1 
ATOM   953  H HB2  . ASN A 1 63  ? -20.59480 -51.67667 -2.11283  1.000 32.98988 ? 63  ASN A HB2  1 
ATOM   954  H HB3  . ASN A 1 63  ? -19.88663 -51.22594 -0.76430  1.000 32.98988 ? 63  ASN A HB3  1 
ATOM   955  H HD21 . ASN A 1 63  ? -23.25014 -52.11600 -0.14303  1.000 41.71884 ? 63  ASN A HD21 1 
ATOM   956  H HD22 . ASN A 1 63  ? -22.08837 -52.80569 -0.77105  1.000 41.71884 ? 63  ASN A HD22 1 
ATOM   957  N N    . HIS A 1 64  ? -18.30432 -50.36594 -3.58821  1.000 28.08388 ? 64  HIS A N    1 
ATOM   958  C CA   . HIS A 1 64  ? -16.88205 -50.57163 -3.87084  1.000 34.50996 ? 64  HIS A CA   1 
ATOM   959  C C    . HIS A 1 64  ? -16.20487 -49.31276 -4.40282  1.000 28.15792 ? 64  HIS A C    1 
ATOM   960  O O    . HIS A 1 64  ? -14.97483 -49.29470 -4.53438  1.000 33.09320 ? 64  HIS A O    1 
ATOM   961  C CB   . HIS A 1 64  ? -16.64678 -51.73183 -4.87147  1.000 34.30717 ? 64  HIS A CB   1 
ATOM   962  C CG   . HIS A 1 64  ? -17.18349 -51.48140 -6.24950  1.000 30.20947 ? 64  HIS A CG   1 
ATOM   963  N ND1  . HIS A 1 64  ? -18.43001 -51.91015 -6.64921  1.000 38.49684 ? 64  HIS A ND1  1 
ATOM   964  C CD2  . HIS A 1 64  ? -16.63961 -50.85531 -7.32293  1.000 32.99123 ? 64  HIS A CD2  1 
ATOM   965  C CE1  . HIS A 1 64  ? -18.63285 -51.55054 -7.90806  1.000 37.97941 ? 64  HIS A CE1  1 
ATOM   966  N NE2  . HIS A 1 64  ? -17.56822 -50.89442 -8.33428  1.000 29.41101 ? 64  HIS A NE2  1 
ATOM   967  H H    . HIS A 1 64  ? -18.85287 -50.66201 -4.18059  1.000 33.70066 ? 64  HIS A H    1 
ATOM   968  H HA   . HIS A 1 64  ? -16.45814 -50.83480 -3.03885  1.000 41.41196 ? 64  HIS A HA   1 
ATOM   969  H HB2  . HIS A 1 64  ? -15.69163 -51.88202 -4.95222  1.000 41.16860 ? 64  HIS A HB2  1 
ATOM   970  H HB3  . HIS A 1 64  ? -17.08026 -52.52838 -4.52811  1.000 41.16860 ? 64  HIS A HB3  1 
ATOM   971  H HD2  . HIS A 1 64  ? -15.79390 -50.47061 -7.36639  1.000 39.58947 ? 64  HIS A HD2  1 
ATOM   972  H HE1  . HIS A 1 64  ? -19.39653 -51.73084 -8.40744  1.000 45.57529 ? 64  HIS A HE1  1 
ATOM   973  H HE2  . HIS A 1 64  ? -17.47322 -50.54887 -9.11503  1.000 35.29321 ? 64  HIS A HE2  1 
ATOM   974  N N    . ASN A 1 65  ? -16.96958 -48.26916 -4.73645  1.000 32.40233 ? 65  ASN A N    1 
ATOM   975  C CA   . ASN A 1 65  ? -16.36246 -46.99544 -5.11945  1.000 27.67612 ? 65  ASN A CA   1 
ATOM   976  C C    . ASN A 1 65  ? -15.81049 -46.23775 -3.91679  1.000 32.25007 ? 65  ASN A C    1 
ATOM   977  O O    . ASN A 1 65  ? -15.06220 -45.26804 -4.09192  1.000 28.60344 ? 65  ASN A O    1 
ATOM   978  C CB   . ASN A 1 65  ? -17.36790 -46.10578 -5.87025  1.000 31.43506 ? 65  ASN A CB   1 
ATOM   979  C CG   . ASN A 1 65  ? -17.82895 -46.70533 -7.19979  1.000 37.26908 ? 65  ASN A CG   1 
ATOM   980  O OD1  . ASN A 1 65  ? -19.02084 -46.71609 -7.50221  1.000 32.58461 ? 65  ASN A OD1  1 
ATOM   981  N ND2  . ASN A 1 65  ? -16.87329 -47.18608 -7.99975  1.000 31.46206 ? 65  ASN A ND2  1 
ATOM   982  H H    . ASN A 1 65  ? -17.82957 -48.27484 -4.74875  1.000 38.88279 ? 65  ASN A H    1 
ATOM   983  H HA   . ASN A 1 65  ? -15.63510 -47.17749 -5.73430  1.000 33.21135 ? 65  ASN A HA   1 
ATOM   984  H HB2  . ASN A 1 65  ? -18.15120 -45.97775 -5.31245  1.000 37.72208 ? 65  ASN A HB2  1 
ATOM   985  H HB3  . ASN A 1 65  ? -16.95052 -45.25033 -6.05758  1.000 37.72208 ? 65  ASN A HB3  1 
ATOM   986  H HD21 . ASN A 1 65  ? -17.08274 -47.53378 -8.75804  1.000 37.75447 ? 65  ASN A HD21 1 
ATOM   987  H HD22 . ASN A 1 65  ? -16.04940 -47.14857 -7.75643  1.000 37.75447 ? 65  ASN A HD22 1 
ATOM   988  N N    . PHE A 1 66  ? -16.15659 -46.64977 -2.69816  1.000 27.93796 ? 66  PHE A N    1 
ATOM   989  C CA   . PHE A 1 66  ? -15.69156 -45.96414 -1.50557  1.000 32.90260 ? 66  PHE A CA   1 
ATOM   990  C C    . PHE A 1 66  ? -14.50517 -46.71656 -0.90262  1.000 37.69592 ? 66  PHE A C    1 
ATOM   991  O O    . PHE A 1 66  ? -14.62238 -47.88490 -0.51438  1.000 37.45453 ? 66  PHE A O    1 
ATOM   992  C CB   . PHE A 1 66  ? -16.83103 -45.81566 -0.50288  1.000 30.17132 ? 66  PHE A CB   1 
ATOM   993  C CG   . PHE A 1 66  ? -17.92457 -44.91823 -0.99172  1.000 28.44834 ? 66  PHE A CG   1 
ATOM   994  C CD1  . PHE A 1 66  ? -17.78069 -43.54015 -0.93682  1.000 29.78345 ? 66  PHE A CD1  1 
ATOM   995  C CD2  . PHE A 1 66  ? -19.10397 -45.44887 -1.48346  1.000 32.84041 ? 66  PHE A CD2  1 
ATOM   996  C CE1  . PHE A 1 66  ? -18.78619 -42.71368 -1.37666  1.000 32.73665 ? 66  PHE A CE1  1 
ATOM   997  C CE2  . PHE A 1 66  ? -20.11747 -44.62740 -1.92331  1.000 31.06976 ? 66  PHE A CE2  1 
ATOM   998  C CZ   . PHE A 1 66  ? -19.95459 -43.24831 -1.85840  1.000 24.83267 ? 66  PHE A CZ   1 
ATOM   999  H H    . PHE A 1 66  ? -16.66110 -47.32827 -2.54176  1.000 33.52555 ? 66  PHE A H    1 
ATOM   1000 H HA   . PHE A 1 66  ? -15.37518 -45.07774 -1.74092  1.000 39.48311 ? 66  PHE A HA   1 
ATOM   1001 H HB2  . PHE A 1 66  ? -17.21539 -46.69007 -0.33056  1.000 36.20559 ? 66  PHE A HB2  1 
ATOM   1002 H HB3  . PHE A 1 66  ? -16.47962 -45.43989 0.31947   1.000 36.20559 ? 66  PHE A HB3  1 
ATOM   1003 H HD1  . PHE A 1 66  ? -16.99610 -43.17173 -0.59931  1.000 35.74014 ? 66  PHE A HD1  1 
ATOM   1004 H HD2  . PHE A 1 66  ? -19.21323 -46.37193 -1.51807  1.000 39.40849 ? 66  PHE A HD2  1 
ATOM   1005 H HE1  . PHE A 1 66  ? -18.67493 -41.79161 -1.34705  1.000 39.28398 ? 66  PHE A HE1  1 
ATOM   1006 H HE2  . PHE A 1 66  ? -20.90406 -44.99182 -2.26081  1.000 37.28371 ? 66  PHE A HE2  1 
ATOM   1007 H HZ   . PHE A 1 66  ? -20.63994 -42.68668 -2.14230  1.000 29.79920 ? 66  PHE A HZ   1 
ATOM   1008 N N    . LEU A 1 67  ? -13.38576 -46.02073 -0.80980  1.000 27.57676 ? 67  LEU A N    1 
ATOM   1009 C CA   . LEU A 1 67  ? -12.09146 -46.55292 -0.45567  1.000 35.68197 ? 67  LEU A CA   1 
ATOM   1010 C C    . LEU A 1 67  ? -11.77537 -46.02653 0.94077   1.000 35.48735 ? 67  LEU A C    1 
ATOM   1011 O O    . LEU A 1 67  ? -11.48337 -44.83539 1.10161   1.000 28.72723 ? 67  LEU A O    1 
ATOM   1012 C CB   . LEU A 1 67  ? -11.09748 -46.06348 -1.49801  1.000 42.17420 ? 67  LEU A CB   1 
ATOM   1013 C CG   . LEU A 1 67  ? -10.70534 -46.97346 -2.65344  1.000 42.43571 ? 67  LEU A CG   1 
ATOM   1014 C CD1  . LEU A 1 67  ? -9.33057  -46.49009 -3.09465  1.000 46.13030 ? 67  LEU A CD1  1 
ATOM   1015 C CD2  . LEU A 1 67  ? -10.66034 -48.41667 -2.25431  1.000 39.42683 ? 67  LEU A CD2  1 
ATOM   1016 H H    . LEU A 1 67  ? -13.35238 -45.17461 -0.96026  1.000 33.09211 ? 67  LEU A H    1 
ATOM   1017 H HA   . LEU A 1 67  ? -12.06970 -47.52192 -0.41926  1.000 42.81836 ? 67  LEU A HA   1 
ATOM   1018 H HB2  . LEU A 1 67  ? -11.47197 -45.26353 -1.89965  1.000 50.60904 ? 67  LEU A HB2  1 
ATOM   1019 H HB3  . LEU A 1 67  ? -10.27481 -45.84712 -1.03259  1.000 50.60904 ? 67  LEU A HB3  1 
ATOM   1020 H HG   . LEU A 1 67  ? -11.35512 -46.93353 -3.37264  1.000 50.92285 ? 67  LEU A HG   1 
ATOM   1021 H HD11 . LEU A 1 67  ? -9.02487  -47.03940 -3.83289  1.000 55.35636 ? 67  LEU A HD11 1 
ATOM   1022 H HD12 . LEU A 1 67  ? -9.39721  -45.56397 -3.37611  1.000 55.35636 ? 67  LEU A HD12 1 
ATOM   1023 H HD13 . LEU A 1 67  ? -8.71478  -46.56606 -2.34848  1.000 55.35636 ? 67  LEU A HD13 1 
ATOM   1024 H HD21 . LEU A 1 67  ? -10.32366 -48.93994 -2.99852  1.000 47.31220 ? 67  LEU A HD21 1 
ATOM   1025 H HD22 . LEU A 1 67  ? -10.07353 -48.51468 -1.48816  1.000 47.31220 ? 67  LEU A HD22 1 
ATOM   1026 H HD23 . LEU A 1 67  ? -11.55619 -48.70853 -2.02381  1.000 47.31220 ? 67  LEU A HD23 1 
ATOM   1027 N N    . VAL A 1 68  ? -11.85703 -46.89421 1.94721   1.000 31.38243 ? 68  VAL A N    1 
ATOM   1028 C CA   . VAL A 1 68  ? -11.69186 -46.46994 3.33753   1.000 31.83695 ? 68  VAL A CA   1 
ATOM   1029 C C    . VAL A 1 68  ? -10.49053 -47.15736 3.95453   1.000 37.93334 ? 68  VAL A C    1 
ATOM   1030 O O    . VAL A 1 68  ? -10.44058 -48.39137 4.02478   1.000 35.76695 ? 68  VAL A O    1 
ATOM   1031 C CB   . VAL A 1 68  ? -12.93494 -46.75146 4.19491   1.000 33.21518 ? 68  VAL A CB   1 
ATOM   1032 C CG1  . VAL A 1 68  ? -12.71086 -46.22315 5.61432   1.000 33.72264 ? 68  VAL A CG1  1 
ATOM   1033 C CG2  . VAL A 1 68  ? -14.14622 -46.12103 3.56488   1.000 33.90158 ? 68  VAL A CG2  1 
ATOM   1034 H H    . VAL A 1 68  ? -12.00733 -47.73527 1.85063   1.000 37.65892 ? 68  VAL A H    1 
ATOM   1035 H HA   . VAL A 1 68  ? -11.52362 -45.51479 3.32117   1.000 38.20433 ? 68  VAL A HA   1 
ATOM   1036 H HB   . VAL A 1 68  ? -13.09220 -47.70661 4.24927   1.000 39.85822 ? 68  VAL A HB   1 
ATOM   1037 H HG11 . VAL A 1 68  ? -13.55503 -46.23312 6.09202   1.000 40.46717 ? 68  VAL A HG11 1 
ATOM   1038 H HG12 . VAL A 1 68  ? -12.06857 -46.79292 6.06519   1.000 40.46717 ? 68  VAL A HG12 1 
ATOM   1039 H HG13 . VAL A 1 68  ? -12.37057 -45.31585 5.56300   1.000 40.46717 ? 68  VAL A HG13 1 
ATOM   1040 H HG21 . VAL A 1 68  ? -14.91630 -46.27900 4.13351   1.000 40.68190 ? 68  VAL A HG21 1 
ATOM   1041 H HG22 . VAL A 1 68  ? -13.99395 -45.16785 3.47152   1.000 40.68190 ? 68  VAL A HG22 1 
ATOM   1042 H HG23 . VAL A 1 68  ? -14.29260 -46.52061 2.69258   1.000 40.68190 ? 68  VAL A HG23 1 
ATOM   1043 N N    . GLN A 1 69  ? -9.58837  -46.35398 4.50234   1.000 33.15695 ? 69  GLN A N    1 
ATOM   1044 C CA   . GLN A 1 69  ? -8.29716  -46.82224 4.96351   1.000 40.74206 ? 69  GLN A CA   1 
ATOM   1045 C C    . GLN A 1 69  ? -8.03309  -46.25888 6.35195   1.000 43.95190 ? 69  GLN A C    1 
ATOM   1046 O O    . GLN A 1 69  ? -8.06413  -45.04103 6.55069   1.000 29.04695 ? 69  GLN A O    1 
ATOM   1047 C CB   . GLN A 1 69  ? -7.23716  -46.38178 3.97315   1.000 42.90695 ? 69  GLN A CB   1 
ATOM   1048 C CG   . GLN A 1 69  ? -5.88094  -46.79090 4.29838   1.000 53.27587 ? 69  GLN A CG   1 
ATOM   1049 C CD   . GLN A 1 69  ? -5.04547  -46.83647 3.04765   1.000 53.26391 ? 69  GLN A CD   1 
ATOM   1050 O OE1  . GLN A 1 69  ? -5.17684  -45.98003 2.16813   1.000 52.96695 ? 69  GLN A OE1  1 
ATOM   1051 N NE2  . GLN A 1 69  ? -4.21361  -47.85774 2.93631   1.000 59.08126 ? 69  GLN A NE2  1 
ATOM   1052 H H    . GLN A 1 69  ? -9.70808  -45.51015 4.61882   1.000 39.78833 ? 69  GLN A H    1 
ATOM   1053 H HA   . GLN A 1 69  ? -8.28342  -47.78828 5.04592   1.000 48.89048 ? 69  GLN A HA   1 
ATOM   1054 H HB2  . GLN A 1 69  ? -7.45355  -46.75742 3.10484   1.000 51.48833 ? 69  GLN A HB2  1 
ATOM   1055 H HB3  . GLN A 1 69  ? -7.24491  -45.41276 3.92575   1.000 51.48833 ? 69  GLN A HB3  1 
ATOM   1056 H HG2  . GLN A 1 69  ? -5.48667  -46.15297 4.91391   1.000 63.93104 ? 69  GLN A HG2  1 
ATOM   1057 H HG3  . GLN A 1 69  ? -5.89338  -47.67416 4.69783   1.000 63.93104 ? 69  GLN A HG3  1 
ATOM   1058 H HE21 . GLN A 1 69  ? -4.17336  -48.44909 3.55996   1.000 70.89751 ? 69  GLN A HE21 1 
ATOM   1059 H HE22 . GLN A 1 69  ? -3.71331  -47.93191 2.24044   1.000 70.89751 ? 69  GLN A HE22 1 
ATOM   1060 N N    . ALA A 1 70  ? -7.79272  -47.14928 7.31048   1.000 46.80630 ? 70  ALA A N    1 
ATOM   1061 C CA   . ALA A 1 70  ? -7.43850  -46.78684 8.67983   1.000 42.41890 ? 70  ALA A CA   1 
ATOM   1062 C C    . ALA A 1 70  ? -5.96728  -47.14278 8.86213   1.000 49.57067 ? 70  ALA A C    1 
ATOM   1063 O O    . ALA A 1 70  ? -5.60635  -48.32652 8.89653   1.000 47.93184 ? 70  ALA A O    1 
ATOM   1064 C CB   . ALA A 1 70  ? -8.31928  -47.51417 9.69307   1.000 38.85078 ? 70  ALA A CB   1 
ATOM   1065 H H    . ALA A 1 70  ? -7.82900  -48.00023 7.18695   1.000 56.16756 ? 70  ALA A H    1 
ATOM   1066 H HA   . ALA A 1 70  ? -7.56130  -45.83503 8.81838   1.000 50.90268 ? 70  ALA A HA   1 
ATOM   1067 H HB1  . ALA A 1 70  ? -8.07682  -47.22553 10.58734  1.000 46.62094 ? 70  ALA A HB1  1 
ATOM   1068 H HB2  . ALA A 1 70  ? -9.24839  -47.29780 9.51688   1.000 46.62094 ? 70  ALA A HB2  1 
ATOM   1069 H HB3  . ALA A 1 70  ? -8.18048  -48.47001 9.60453   1.000 46.62094 ? 70  ALA A HB3  1 
ATOM   1070 N N    . GLY A 1 71  ? -5.11512  -46.13218 8.98206   1.000 50.11499 ? 71  GLY A N    1 
ATOM   1071 C CA   . GLY A 1 71  ? -3.69885  -46.42198 8.86738   1.000 44.82855 ? 71  GLY A CA   1 
ATOM   1072 C C    . GLY A 1 71  ? -3.50178  -47.20104 7.59097   1.000 50.40141 ? 71  GLY A C    1 
ATOM   1073 O O    . GLY A 1 71  ? -4.04469  -46.84482 6.54199   1.000 55.65132 ? 71  GLY A O    1 
ATOM   1074 H H    . GLY A 1 71  ? -5.32283  -45.30943 9.12249   1.000 60.13799 ? 71  GLY A H    1 
ATOM   1075 H HA2  . GLY A 1 71  ? -3.18449  -45.60055 8.83107   1.000 53.79427 ? 71  GLY A HA2  1 
ATOM   1076 H HA3  . GLY A 1 71  ? -3.39770  -46.95021 9.62216   1.000 53.79427 ? 71  GLY A HA3  1 
ATOM   1077 N N    . ASN A 1 72  ? -2.77992  -48.31651 7.65853   1.000 54.39874 ? 72  ASN A N    1 
ATOM   1078 C CA   . ASN A 1 72  ? -2.62284  -49.13764 6.46208   1.000 56.21873 ? 72  ASN A CA   1 
ATOM   1079 C C    . ASN A 1 72  ? -3.75497  -50.14644 6.28406   1.000 55.92286 ? 72  ASN A C    1 
ATOM   1080 O O    . ASN A 1 72  ? -3.88213  -50.72587 5.19866   1.000 60.86293 ? 72  ASN A O    1 
ATOM   1081 C CB   . ASN A 1 72  ? -1.27127  -49.86058 6.48311   1.000 67.65695 ? 72  ASN A CB   1 
ATOM   1082 H H    . ASN A 1 72  ? -2.38293  -48.60862 8.36349   1.000 65.27848 ? 72  ASN A H    1 
ATOM   1083 H HA   . ASN A 1 72  ? -2.62403  -48.55916 5.68344   1.000 67.46248 ? 72  ASN A HA   1 
ATOM   1084 N N    . VAL A 1 73  ? -4.59618  -50.34573 7.30364   1.000 55.55970 ? 73  VAL A N    1 
ATOM   1085 C CA   . VAL A 1 73  ? -5.72040  -51.26555 7.17168   1.000 52.17408 ? 73  VAL A CA   1 
ATOM   1086 C C    . VAL A 1 73  ? -6.69646  -50.72868 6.12766   1.000 55.34523 ? 73  VAL A C    1 
ATOM   1087 O O    . VAL A 1 73  ? -6.94839  -49.51983 6.04532   1.000 52.25790 ? 73  VAL A O    1 
ATOM   1088 C CB   . VAL A 1 73  ? -6.44272  -51.46395 8.51630   1.000 52.99334 ? 73  VAL A CB   1 
ATOM   1089 C CG1  . VAL A 1 73  ? -7.56483  -52.50976 8.37726   1.000 52.44246 ? 73  VAL A CG1  1 
ATOM   1090 C CG2  . VAL A 1 73  ? -5.45982  -51.82486 9.63343   1.000 62.12691 ? 73  VAL A CG2  1 
ATOM   1091 H H    . VAL A 1 73  ? -4.53575  -49.96416 8.07190   1.000 66.67164 ? 73  VAL A H    1 
ATOM   1092 H HA   . VAL A 1 73  ? -5.37461  -52.12510 6.88327   1.000 62.60889 ? 73  VAL A HA   1 
ATOM   1093 H HB   . VAL A 1 73  ? -6.85647  -50.62544 8.77367   1.000 63.59201 ? 73  VAL A HB   1 
ATOM   1094 H HG11 . VAL A 1 73  ? -7.91898  -52.71258 9.25701   1.000 62.93096 ? 73  VAL A HG11 1 
ATOM   1095 H HG12 . VAL A 1 73  ? -8.26592  -52.14797 7.81324   1.000 62.93096 ? 73  VAL A HG12 1 
ATOM   1096 H HG13 . VAL A 1 73  ? -7.19905  -53.31322 7.97489   1.000 62.93096 ? 73  VAL A HG13 1 
ATOM   1097 H HG21 . VAL A 1 73  ? -5.89255  -52.43758 10.24889  1.000 74.55230 ? 73  VAL A HG21 1 
ATOM   1098 H HG22 . VAL A 1 73  ? -4.67835  -52.24600 9.24244   1.000 74.55230 ? 73  VAL A HG22 1 
ATOM   1099 H HG23 . VAL A 1 73  ? -5.20163  -51.01494 10.10002  1.000 74.55230 ? 73  VAL A HG23 1 
ATOM   1100 N N    . GLN A 1 74  ? -7.25246  -51.63063 5.32391   1.000 55.59712 ? 74  GLN A N    1 
ATOM   1101 C CA   . GLN A 1 74  ? -8.34338  -51.31794 4.41372   1.000 49.23238 ? 74  GLN A CA   1 
ATOM   1102 C C    . GLN A 1 74  ? -9.63919  -51.83235 5.03494   1.000 48.73516 ? 74  GLN A C    1 
ATOM   1103 O O    . GLN A 1 74  ? -9.69346  -52.96869 5.51622   1.000 41.51931 ? 74  GLN A O    1 
ATOM   1104 C CB   . GLN A 1 74  ? -8.10439  -51.95190 3.04341   1.000 52.16074 ? 74  GLN A CB   1 
ATOM   1105 C CG   . GLN A 1 74  ? -8.58365  -51.10356 1.86477   1.000 55.07891 ? 74  GLN A CG   1 
ATOM   1106 C CD   . GLN A 1 74  ? -7.55534  -50.05748 1.44377   1.000 58.99663 ? 74  GLN A CD   1 
ATOM   1107 O OE1  . GLN A 1 74  ? -6.45659  -49.99095 2.00320   1.000 59.57219 ? 74  GLN A OE1  1 
ATOM   1108 N NE2  . GLN A 1 74  ? -7.91565  -49.22616 0.46216   1.000 63.94934 ? 74  GLN A NE2  1 
ATOM   1109 H H    . GLN A 1 74  ? -7.00579  -52.45341 5.28949   1.000 66.71654 ? 74  GLN A H    1 
ATOM   1110 H HA   . GLN A 1 74  ? -8.41710  -50.35991 4.28028   1.000 59.07885 ? 74  GLN A HA   1 
ATOM   1111 H HB2  . GLN A 1 74  ? -7.15224  -52.09808 2.93166   1.000 62.59289 ? 74  GLN A HB2  1 
ATOM   1112 H HB3  . GLN A 1 74  ? -8.57671  -52.79826 3.00672   1.000 62.59289 ? 74  GLN A HB3  1 
ATOM   1113 H HG2  . GLN A 1 74  ? -8.75292  -51.68322 1.10535   1.000 66.09470 ? 74  GLN A HG2  1 
ATOM   1114 H HG3  . GLN A 1 74  ? -9.39811  -50.64136 2.11776   1.000 66.09470 ? 74  GLN A HG3  1 
ATOM   1115 H HE21 . GLN A 1 74  ? -8.69347  -49.29856 0.10284   1.000 76.73921 ? 74  GLN A HE21 1 
ATOM   1116 H HE22 . GLN A 1 74  ? -7.37104  -48.61956 0.19072   1.000 76.73921 ? 74  GLN A HE22 1 
ATOM   1117 N N    . LEU A 1 75  ? -10.65788 -50.99019 5.08410   1.000 35.75695 ? 75  LEU A N    1 
ATOM   1118 C CA   . LEU A 1 75  ? -11.96567 -51.44951 5.52336   1.000 39.68362 ? 75  LEU A CA   1 
ATOM   1119 C C    . LEU A 1 75  ? -12.80095 -51.81642 4.30284   1.000 42.13232 ? 75  LEU A C    1 
ATOM   1120 O O    . LEU A 1 75  ? -12.64102 -51.24862 3.21524   1.000 51.25292 ? 75  LEU A O    1 
ATOM   1121 C CB   . LEU A 1 75  ? -12.67481 -50.39158 6.35876   1.000 38.05044 ? 75  LEU A CB   1 
ATOM   1122 C CG   . LEU A 1 75  ? -11.81375 -49.67354 7.40051   1.000 40.61527 ? 75  LEU A CG   1 
ATOM   1123 C CD1  . LEU A 1 75  ? -12.76471 -48.85584 8.28368   1.000 32.26319 ? 75  LEU A CD1  1 
ATOM   1124 C CD2  . LEU A 1 75  ? -11.00932 -50.60245 8.29222   1.000 45.04875 ? 75  LEU A CD2  1 
ATOM   1125 H H    . LEU A 1 75  ? -10.61747 -50.15803 4.87063   1.000 42.90833 ? 75  LEU A H    1 
ATOM   1126 H HA   . LEU A 1 75  ? -11.87024 -52.23577 6.08391   1.000 47.62035 ? 75  LEU A HA   1 
ATOM   1127 H HB2  . LEU A 1 75  ? -13.02314 -49.71449 5.75806   1.000 45.66053 ? 75  LEU A HB2  1 
ATOM   1128 H HB3  . LEU A 1 75  ? -13.40364 -50.82046 6.83524   1.000 45.66053 ? 75  LEU A HB3  1 
ATOM   1129 H HG   . LEU A 1 75  ? -11.16302 -49.12873 6.93107   1.000 48.73833 ? 75  LEU A HG   1 
ATOM   1130 H HD11 . LEU A 1 75  ? -12.25041 -48.19974 8.77826   1.000 38.71583 ? 75  LEU A HD11 1 
ATOM   1131 H HD12 . LEU A 1 75  ? -13.41387 -48.40901 7.71872   1.000 38.71583 ? 75  LEU A HD12 1 
ATOM   1132 H HD13 . LEU A 1 75  ? -13.21745 -49.45358 8.89915   1.000 38.71583 ? 75  LEU A HD13 1 
ATOM   1133 H HD21 . LEU A 1 75  ? -10.67199 -50.09965 9.04965   1.000 54.05850 ? 75  LEU A HD21 1 
ATOM   1134 H HD22 . LEU A 1 75  ? -11.58486 -51.32010 8.60157   1.000 54.05850 ? 75  LEU A HD22 1 
ATOM   1135 H HD23 . LEU A 1 75  ? -10.26985 -50.96855 7.78226   1.000 54.05850 ? 75  LEU A HD23 1 
ATOM   1136 N N    . ARG A 1 76  ? -13.68124 -52.78323 4.48293   1.000 33.34246 ? 76  ARG A N    1 
ATOM   1137 C CA   . ARG A 1 76  ? -14.55151 -53.23527 3.41635   1.000 35.40931 ? 76  ARG A CA   1 
ATOM   1138 C C    . ARG A 1 76  ? -15.90211 -52.57647 3.63028   1.000 42.81111 ? 76  ARG A C    1 
ATOM   1139 O O    . ARG A 1 76  ? -16.46543 -52.66060 4.72902   1.000 33.06477 ? 76  ARG A O    1 
ATOM   1140 C CB   . ARG A 1 76  ? -14.66829 -54.75936 3.41036   1.000 42.86622 ? 76  ARG A CB   1 
ATOM   1141 C CG   . ARG A 1 76  ? -15.49144 -55.31931 2.26473   1.000 42.56399 ? 76  ARG A CG   1 
ATOM   1142 C CD   . ARG A 1 76  ? -15.66432 -56.82157 2.46074   1.000 41.23876 ? 76  ARG A CD   1 
ATOM   1143 N NE   . ARG A 1 76  ? -14.38976 -57.53959 2.51875   1.000 48.04650 ? 76  ARG A NE   1 
ATOM   1144 C CZ   . ARG A 1 76  ? -13.65814 -57.85335 1.45481   1.000 45.75953 ? 76  ARG A CZ   1 
ATOM   1145 N NH1  . ARG A 1 76  ? -14.05994 -57.55791 0.23085   1.000 39.22057 ? 76  ARG A NH1  1 
ATOM   1146 N NH2  . ARG A 1 76  ? -12.50169 -58.49353 1.62283   1.000 42.59695 ? 76  ARG A NH2  1 
ATOM   1147 H H    . ARG A 1 76  ? -13.79417 -53.20078 5.22663   1.000 40.01095 ? 76  ARG A H    1 
ATOM   1148 H HA   . ARG A 1 76  ? -14.20540 -52.98145 2.54662   1.000 42.49117 ? 76  ARG A HA   1 
ATOM   1149 H HB2  . ARG A 1 76  ? -13.77797 -55.13761 3.34445   1.000 51.43946 ? 76  ARG A HB2  1 
ATOM   1150 H HB3  . ARG A 1 76  ? -15.08836 -55.04120 4.23804   1.000 51.43946 ? 76  ARG A HB3  1 
ATOM   1151 H HG2  . ARG A 1 76  ? -16.36577 -54.90099 2.25068   1.000 51.07678 ? 76  ARG A HG2  1 
ATOM   1152 H HG3  . ARG A 1 76  ? -15.03527 -55.16242 1.42299   1.000 51.07678 ? 76  ARG A HG3  1 
ATOM   1153 H HD2  . ARG A 1 76  ? -16.13349 -56.97845 3.29548   1.000 49.48651 ? 76  ARG A HD2  1 
ATOM   1154 H HD3  . ARG A 1 76  ? -16.17577 -57.17952 1.71934   1.000 49.48651 ? 76  ARG A HD3  1 
ATOM   1155 H HE   . ARG A 1 76  ? -14.09585 -57.77483 3.29171   1.000 57.65580 ? 76  ARG A HE   1 
ATOM   1156 H HH11 . ARG A 1 76  ? -14.81022 -57.15444 0.11084   1.000 47.06469 ? 76  ARG A HH11 1 
ATOM   1157 H HH12 . ARG A 1 76  ? -13.57153 -57.76911 -0.44411  1.000 47.06469 ? 76  ARG A HH12 1 
ATOM   1158 H HH21 . ARG A 1 76  ? -12.23580 -58.70081 2.41379   1.000 51.11633 ? 76  ARG A HH21 1 
ATOM   1159 H HH22 . ARG A 1 76  ? -12.02128 -58.70073 0.93987   1.000 51.11633 ? 76  ARG A HH22 1 
ATOM   1160 N N    . VAL A 1 77  ? -16.38429 -51.88922 2.59053   1.000 37.44061 ? 77  VAL A N    1 
ATOM   1161 C CA   . VAL A 1 77  ? -17.61392 -51.11623 2.64257   1.000 34.50694 ? 77  VAL A CA   1 
ATOM   1162 C C    . VAL A 1 77  ? -18.76807 -51.98786 2.18163   1.000 38.43283 ? 77  VAL A C    1 
ATOM   1163 O O    . VAL A 1 77  ? -18.79330 -52.44418 1.03634   1.000 32.01059 ? 77  VAL A O    1 
ATOM   1164 C CB   . VAL A 1 77  ? -17.51962 -49.85362 1.77338   1.000 30.92628 ? 77  VAL A CB   1 
ATOM   1165 C CG1  . VAL A 1 77  ? -18.87121 -49.11469 1.76736   1.000 31.42123 ? 77  VAL A CG1  1 
ATOM   1166 C CG2  . VAL A 1 77  ? -16.39951 -48.94501 2.24734   1.000 34.77701 ? 77  VAL A CG2  1 
ATOM   1167 H H    . VAL A 1 77  ? -16.00004 -51.85844 1.82268   1.000 44.92873 ? 77  VAL A H    1 
ATOM   1168 H HA   . VAL A 1 77  ? -17.77345 -50.85592 3.56368   1.000 41.40833 ? 77  VAL A HA   1 
ATOM   1169 H HB   . VAL A 1 77  ? -17.31109 -50.11289 0.86230   1.000 37.11154 ? 77  VAL A HB   1 
ATOM   1170 H HG11 . VAL A 1 77  ? -18.76073 -48.25733 1.32593   1.000 37.70548 ? 77  VAL A HG11 1 
ATOM   1171 H HG12 . VAL A 1 77  ? -19.52261 -49.65091 1.28880   1.000 37.70548 ? 77  VAL A HG12 1 
ATOM   1172 H HG13 . VAL A 1 77  ? -19.16164 -48.98048 2.68234   1.000 37.70548 ? 77  VAL A HG13 1 
ATOM   1173 H HG21 . VAL A 1 77  ? -16.43800 -48.11174 1.75284   1.000 41.73241 ? 77  VAL A HG21 1 
ATOM   1174 H HG22 . VAL A 1 77  ? -16.51198 -48.77269 3.19541   1.000 41.73241 ? 77  VAL A HG22 1 
ATOM   1175 H HG23 . VAL A 1 77  ? -15.54910 -49.38424 2.09037   1.000 41.73241 ? 77  VAL A HG23 1 
ATOM   1176 N N    . ILE A 1 78  ? -19.77024 -52.15119 3.04017   1.000 37.22409 ? 78  ILE A N    1 
ATOM   1177 C CA   . ILE A 1 78  ? -20.87042 -53.05288 2.74623   1.000 34.62632 ? 78  ILE A CA   1 
ATOM   1178 C C    . ILE A 1 78  ? -22.21499 -52.34697 2.76419   1.000 37.25822 ? 78  ILE A C    1 
ATOM   1179 O O    . ILE A 1 78  ? -23.25844 -52.98973 2.66342   1.000 36.78221 ? 78  ILE A O    1 
ATOM   1180 C CB   . ILE A 1 78  ? -20.85781 -54.24747 3.71650   1.000 32.37898 ? 78  ILE A CB   1 
ATOM   1181 C CG1  . ILE A 1 78  ? -21.21365 -53.82063 5.13463   1.000 42.31830 ? 78  ILE A CG1  1 
ATOM   1182 C CG2  . ILE A 1 78  ? -19.46235 -54.85241 3.78962   1.000 26.13695 ? 78  ILE A CG2  1 
ATOM   1183 C CD1  . ILE A 1 78  ? -21.20008 -54.98724 6.14092   1.000 34.59486 ? 78  ILE A CD1  1 
ATOM   1184 H H    . ILE A 1 78  ? -19.83183 -51.74870 3.79740   1.000 44.66891 ? 78  ILE A H    1 
ATOM   1185 H HA   . ILE A 1 78  ? -20.75483 -53.39424 1.84606   1.000 41.55159 ? 78  ILE A HA   1 
ATOM   1186 H HB   . ILE A 1 78  ? -21.51019 -54.88078 3.37788   1.000 38.85478 ? 78  ILE A HB   1 
ATOM   1187 H HG12 . ILE A 1 78  ? -20.56928 -53.16030 5.43527   1.000 50.78196 ? 78  ILE A HG12 1 
ATOM   1188 H HG13 . ILE A 1 78  ? -22.10496 -53.43834 5.13356   1.000 50.78196 ? 78  ILE A HG13 1 
ATOM   1189 H HG21 . ILE A 1 78  ? -19.51880 -55.72771 4.20306   1.000 31.36433 ? 78  ILE A HG21 1 
ATOM   1190 H HG22 . ILE A 1 78  ? -19.10497 -54.93257 2.89169   1.000 31.36433 ? 78  ILE A HG22 1 
ATOM   1191 H HG23 . ILE A 1 78  ? -18.89400 -54.27228 4.32117   1.000 31.36433 ? 78  ILE A HG23 1 
ATOM   1192 H HD11 . ILE A 1 78  ? -21.64259 -54.70509 6.95694   1.000 41.51383 ? 78  ILE A HD11 1 
ATOM   1193 H HD12 . ILE A 1 78  ? -21.67034 -55.74238 5.75429   1.000 41.51383 ? 78  ILE A HD12 1 
ATOM   1194 H HD13 . ILE A 1 78  ? -20.28095 -55.23062 6.32909   1.000 41.51383 ? 78  ILE A HD13 1 
ATOM   1195 N N    . GLY A 1 79  ? -22.21007 -51.03804 2.88900   1.000 36.17310 ? 79  GLY A N    1 
ATOM   1196 C CA   . GLY A 1 79  ? -23.43965 -50.29299 2.84102   1.000 35.96522 ? 79  GLY A CA   1 
ATOM   1197 C C    . GLY A 1 79  ? -23.09179 -48.83066 2.76405   1.000 30.28788 ? 79  GLY A C    1 
ATOM   1198 O O    . GLY A 1 79  ? -22.07733 -48.40020 3.32467   1.000 34.25211 ? 79  GLY A O    1 
ATOM   1199 H H    . GLY A 1 79  ? -21.50449 -50.55855 3.00254   1.000 43.40772 ? 79  GLY A H    1 
ATOM   1200 H HA2  . GLY A 1 79  ? -23.95717 -50.54592 2.05968   1.000 43.15826 ? 79  GLY A HA2  1 
ATOM   1201 H HA3  . GLY A 1 79  ? -23.96780 -50.45990 3.63673   1.000 43.15826 ? 79  GLY A HA3  1 
ATOM   1202 N N    . HIS A 1 80  ? -23.89717 -48.04688 2.07725   1.000 35.32082 ? 80  HIS A N    1 
ATOM   1203 C CA   . HIS A 1 80  ? -23.68429 -46.61569 2.03920   1.000 25.67608 ? 80  HIS A CA   1 
ATOM   1204 C C    . HIS A 1 80  ? -25.03684 -45.93877 2.06014   1.000 39.32444 ? 80  HIS A C    1 
ATOM   1205 O O    . HIS A 1 80  ? -26.02925 -46.42522 1.49549   1.000 30.98180 ? 80  HIS A O    1 
ATOM   1206 C CB   . HIS A 1 80  ? -22.88221 -46.17329 0.81676   1.000 27.83925 ? 80  HIS A CB   1 
ATOM   1207 C CG   . HIS A 1 80  ? -23.60761 -46.36208 -0.47061  1.000 33.49153 ? 80  HIS A CG   1 
ATOM   1208 N ND1  . HIS A 1 80  ? -23.56042 -47.54561 -1.17133  1.000 37.51617 ? 80  HIS A ND1  1 
ATOM   1209 C CD2  . HIS A 1 80  ? -24.36402 -45.51422 -1.21136  1.000 27.26960 ? 80  HIS A CD2  1 
ATOM   1210 C CE1  . HIS A 1 80  ? -24.28012 -47.43050 -2.27551  1.000 36.71548 ? 80  HIS A CE1  1 
ATOM   1211 N NE2  . HIS A 1 80  ? -24.77808 -46.20887 -2.31993  1.000 29.28617 ? 80  HIS A NE2  1 
ATOM   1212 H H    . HIS A 1 80  ? -24.57579 -48.32014 1.62484   1.000 42.38498 ? 80  HIS A H    1 
ATOM   1213 H HA   . HIS A 1 80  ? -23.17879 -46.33676 2.81855   1.000 30.81130 ? 80  HIS A HA   1 
ATOM   1214 H HB2  . HIS A 1 80  ? -22.67399 -45.23018 0.90441   1.000 33.40710 ? 80  HIS A HB2  1 
ATOM   1215 H HB3  . HIS A 1 80  ? -22.06379 -46.69162 0.77573   1.000 33.40710 ? 80  HIS A HB3  1 
ATOM   1216 H HD1  . HIS A 1 80  ? -23.12994 -48.25042 -0.92861  1.000 45.01941 ? 80  HIS A HD1  1 
ATOM   1217 H HD2  . HIS A 1 80  ? -24.56480 -44.62851 -1.00688  1.000 32.72352 ? 80  HIS A HD2  1 
ATOM   1218 H HE1  . HIS A 1 80  ? -24.41237 -48.09622 -2.91097  1.000 44.05857 ? 80  HIS A HE1  1 
ATOM   1219 N N    . SER A 1 81  ? -25.04798 -44.79218 2.70885   1.000 29.86254 ? 81  SER A N    1 
ATOM   1220 C CA   . SER A 1 81  ? -26.25966 -44.05531 2.97587   1.000 36.28313 ? 81  SER A CA   1 
ATOM   1221 C C    . SER A 1 81  ? -25.86489 -42.60312 3.18291   1.000 34.71988 ? 81  SER A C    1 
ATOM   1222 O O    . SER A 1 81  ? -24.77430 -42.30857 3.68948   1.000 33.19017 ? 81  SER A O    1 
ATOM   1223 C CB   . SER A 1 81  ? -26.98065 -44.61264 4.19628   1.000 25.08201 ? 81  SER A CB   1 
ATOM   1224 O OG   . SER A 1 81  ? -28.15433 -43.86472 4.42832   1.000 52.16614 ? 81  SER A OG   1 
ATOM   1225 H H    . SER A 1 81  ? -24.34139 -44.40881 3.01533   1.000 35.83504 ? 81  SER A H    1 
ATOM   1226 H HA   . SER A 1 81  ? -26.87236 -44.10834 2.22662   1.000 43.53976 ? 81  SER A HA   1 
ATOM   1227 H HB2  . SER A 1 81  ? -27.21586 -45.53973 4.03562   1.000 30.09841 ? 81  SER A HB2  1 
ATOM   1228 H HB3  . SER A 1 81  ? -26.39898 -44.54765 4.97052   1.000 30.09841 ? 81  SER A HB3  1 
ATOM   1229 H HG   . SER A 1 81  ? -28.59627 -44.21045 5.05295   1.000 62.59937 ? 81  SER A HG   1 
ATOM   1230 N N    . MET A 1 82  ? -26.76444 -41.72558 2.76513   1.000 24.12323 ? 82  MET A N    1 
ATOM   1231 C CA   . MET A 1 82  ? -26.62963 -40.28655 2.88907   1.000 28.24707 ? 82  MET A CA   1 
ATOM   1232 C C    . MET A 1 82  ? -27.63835 -39.84600 3.92998   1.000 27.24603 ? 82  MET A C    1 
ATOM   1233 O O    . MET A 1 82  ? -28.84714 -40.02484 3.73145   1.000 27.52189 ? 82  MET A O    1 
ATOM   1234 C CB   . MET A 1 82  ? -26.94372 -39.58599 1.57339   1.000 26.10706 ? 82  MET A CB   1 
ATOM   1235 C CG   . MET A 1 82  ? -26.69892 -38.08980 1.58640   1.000 27.00819 ? 82  MET A CG   1 
ATOM   1236 S SD   . MET A 1 82  ? -26.50193 -37.35064 -0.05208  1.000 27.19259 ? 82  MET A SD   1 
ATOM   1237 C CE   . MET A 1 82  ? -28.07934 -37.75443 -0.80188  1.000 32.20864 ? 82  MET A CE   1 
ATOM   1238 H H    . MET A 1 82  ? -27.50213 -41.95494 2.38573   1.000 28.94787 ? 82  MET A H    1 
ATOM   1239 H HA   . MET A 1 82  ? -25.72190 -40.06199 3.14653   1.000 33.89649 ? 82  MET A HA   1 
ATOM   1240 H HB2  . MET A 1 82  ? -26.38617 -39.96912 0.87835   1.000 31.32848 ? 82  MET A HB2  1 
ATOM   1241 H HB3  . MET A 1 82  ? -27.88054 -39.72761 1.36397   1.000 31.32848 ? 82  MET A HB3  1 
ATOM   1242 H HG2  . MET A 1 82  ? -27.45342 -37.65667 2.01440   1.000 32.40983 ? 82  MET A HG2  1 
ATOM   1243 H HG3  . MET A 1 82  ? -25.88624 -37.91446 2.08679   1.000 32.40983 ? 82  MET A HG3  1 
ATOM   1244 H HE1  . MET A 1 82  ? -28.09530 -37.41088 -1.70868  1.000 38.65037 ? 82  MET A HE1  1 
ATOM   1245 H HE2  . MET A 1 82  ? -28.18657 -38.71851 -0.81152  1.000 38.65037 ? 82  MET A HE2  1 
ATOM   1246 H HE3  . MET A 1 82  ? -28.78985 -37.34832 -0.28188  1.000 38.65037 ? 82  MET A HE3  1 
ATOM   1247 N N    . GLN A 1 83  ? -27.15520 -39.27530 5.04351   1.000 22.75074 ? 83  GLN A N    1 
ATOM   1248 C CA   . GLN A 1 83  ? -28.02306 -38.62859 6.01960   1.000 23.03899 ? 83  GLN A CA   1 
ATOM   1249 C C    . GLN A 1 83  ? -27.71925 -37.12734 6.01163   1.000 26.30210 ? 83  GLN A C    1 
ATOM   1250 O O    . GLN A 1 83  ? -26.65475 -36.70379 6.48627   1.000 22.02517 ? 83  GLN A O    1 
ATOM   1251 C CB   . GLN A 1 83  ? -27.75510 -39.19623 7.40634   1.000 20.15622 ? 83  GLN A CB   1 
ATOM   1252 C CG   . GLN A 1 83  ? -28.44006 -38.47345 8.49955   1.000 27.15538 ? 83  GLN A CG   1 
ATOM   1253 C CD   . GLN A 1 83  ? -28.24700 -39.14013 9.84521   1.000 32.46346 ? 83  GLN A CD   1 
ATOM   1254 O OE1  . GLN A 1 83  ? -27.27750 -39.87449 10.06209  1.000 29.35535 ? 83  GLN A OE1  1 
ATOM   1255 N NE2  . GLN A 1 83  ? -29.18848 -38.93142 10.73700  1.000 30.86528 ? 83  GLN A NE2  1 
ATOM   1256 H H    . GLN A 1 83  ? -26.32129 -39.25476 5.25081   1.000 27.30089 ? 83  GLN A H    1 
ATOM   1257 H HA   . GLN A 1 83  ? -28.95086 -38.76818 5.77418   1.000 27.64679 ? 83  GLN A HA   1 
ATOM   1258 H HB2  . GLN A 1 83  ? -28.05837 -40.11749 7.42767   1.000 24.18746 ? 83  GLN A HB2  1 
ATOM   1259 H HB3  . GLN A 1 83  ? -26.80119 -39.15658 7.57870   1.000 24.18746 ? 83  GLN A HB3  1 
ATOM   1260 H HG2  . GLN A 1 83  ? -28.08380 -37.57220 8.55623   1.000 32.58646 ? 83  GLN A HG2  1 
ATOM   1261 H HG3  . GLN A 1 83  ? -29.39202 -38.44309 8.31223   1.000 32.58646 ? 83  GLN A HG3  1 
ATOM   1262 H HE21 . GLN A 1 83  ? -29.86581 -38.43984 10.54007  1.000 37.03833 ? 83  GLN A HE21 1 
ATOM   1263 H HE22 . GLN A 1 83  ? -29.12848 -39.28686 11.51780  1.000 37.03833 ? 83  GLN A HE22 1 
ATOM   1264 N N    . ASN A 1 84  ? -28.67574 -36.31882 5.56079   1.000 25.13157 ? 84  ASN A N    1 
ATOM   1265 C CA   . ASN A 1 84  ? -28.48783 -34.88159 5.42374   1.000 18.22820 ? 84  ASN A CA   1 
ATOM   1266 C C    . ASN A 1 84  ? -27.18870 -34.70007 4.63331   1.000 18.42751 ? 84  ASN A C    1 
ATOM   1267 O O    . ASN A 1 84  ? -27.10491 -35.17930 3.49205   1.000 20.26626 ? 84  ASN A O    1 
ATOM   1268 C CB   . ASN A 1 84  ? -28.54984 -34.21848 6.79113   1.000 23.64373 ? 84  ASN A CB   1 
ATOM   1269 C CG   . ASN A 1 84  ? -29.83384 -34.53394 7.49048   1.000 24.71686 ? 84  ASN A CG   1 
ATOM   1270 O OD1  . ASN A 1 84  ? -30.91290 -34.22947 6.96829   1.000 25.38115 ? 84  ASN A OD1  1 
ATOM   1271 N ND2  . ASN A 1 84  ? -29.74682 -35.09460 8.68917   1.000 28.22014 ? 84  ASN A ND2  1 
ATOM   1272 H H    . ASN A 1 84  ? -29.45744 -36.58830 5.32335   1.000 30.15789 ? 84  ASN A H    1 
ATOM   1273 H HA   . ASN A 1 84  ? -29.20895 -34.49984 4.89973   1.000 21.87384 ? 84  ASN A HA   1 
ATOM   1274 H HB2  . ASN A 1 84  ? -27.81678 -34.54024 7.33819   1.000 28.37247 ? 84  ASN A HB2  1 
ATOM   1275 H HB3  . ASN A 1 84  ? -28.48757 -33.25637 6.68475   1.000 28.37247 ? 84  ASN A HB3  1 
ATOM   1276 H HD21 . ASN A 1 84  ? -30.46281 -35.29144 9.12480   1.000 33.86417 ? 84  ASN A HD21 1 
ATOM   1277 H HD22 . ASN A 1 84  ? -28.97580 -35.26120 9.03134   1.000 33.86417 ? 84  ASN A HD22 1 
ATOM   1278 N N    . CYS A 1 85  ? -26.17141 -34.03659 5.16908   1.000 16.78343 ? 85  CYS A N    1 
ATOM   1279 C CA   . CYS A 1 85  ? -24.95732 -33.80615 4.39865   1.000 16.57802 ? 85  CYS A CA   1 
ATOM   1280 C C    . CYS A 1 85  ? -23.81375 -34.71049 4.81650   1.000 19.25270 ? 85  CYS A C    1 
ATOM   1281 O O    . CYS A 1 85  ? -22.65284 -34.43134 4.45008   1.000 18.20025 ? 85  CYS A O    1 
ATOM   1282 C CB   . CYS A 1 85  ? -24.53251 -32.34385 4.46670   1.000 18.60345 ? 85  CYS A CB   1 
ATOM   1283 S SG   . CYS A 1 85  ? -25.78028 -31.15654 3.97300   1.000 20.56517 ? 85  CYS A SG   1 
ATOM   1284 H H    . CYS A 1 85  ? -26.16095 -33.71607 5.96728   1.000 20.14011 ? 85  CYS A H    1 
ATOM   1285 H HA   . CYS A 1 85  ? -25.16084 -34.00274 3.47146   1.000 19.89363 ? 85  CYS A HA   1 
ATOM   1286 H HB2  . CYS A 1 85  ? -24.28600 -32.14022 5.38192   1.000 22.32414 ? 85  CYS A HB2  1 
ATOM   1287 H HB3  . CYS A 1 85  ? -23.76840 -32.22088 3.88105   1.000 22.32414 ? 85  CYS A HB3  1 
ATOM   1288 H HG   . CYS A 1 85  ? -25.29862 -30.38767 3.18764   1.000 24.67820 ? 85  CYS A HG   1 
ATOM   1289 N N    . VAL A 1 86  ? -24.08514 -35.79315 5.53374   1.000 18.30088 ? 86  VAL A N    1 
ATOM   1290 C CA   . VAL A 1 86  ? -23.02146 -36.75846 5.78352   1.000 14.66733 ? 86  VAL A CA   1 
ATOM   1291 C C    . VAL A 1 86  ? -23.28717 -38.04220 5.02063   1.000 19.61854 ? 86  VAL A C    1 
ATOM   1292 O O    . VAL A 1 86  ? -24.43277 -38.42694 4.73899   1.000 23.92451 ? 86  VAL A O    1 
ATOM   1293 C CB   . VAL A 1 86  ? -22.74674 -37.07516 7.27442   1.000 24.04271 ? 86  VAL A CB   1 
ATOM   1294 C CG1  . VAL A 1 86  ? -22.13093 -35.86508 7.93938   1.000 27.47716 ? 86  VAL A CG1  1 
ATOM   1295 C CG2  . VAL A 1 86  ? -23.98164 -37.52560 8.01071   1.000 28.33291 ? 86  VAL A CG2  1 
ATOM   1296 H H    . VAL A 1 86  ? -24.85211 -35.98397 5.87435   1.000 21.96105 ? 86  VAL A H    1 
ATOM   1297 H HA   . VAL A 1 86  ? -22.21667 -36.34161 5.43606   1.000 17.60080 ? 86  VAL A HA   1 
ATOM   1298 H HB   . VAL A 1 86  ? -22.12516 -37.81869 7.31718   1.000 28.85126 ? 86  VAL A HB   1 
ATOM   1299 H HG11 . VAL A 1 86  ? -22.43629 -35.82089 8.85930   1.000 32.97260 ? 86  VAL A HG11 1 
ATOM   1300 H HG12 . VAL A 1 86  ? -21.16486 -35.94830 7.91467   1.000 32.97260 ? 86  VAL A HG12 1 
ATOM   1301 H HG13 . VAL A 1 86  ? -22.40640 -35.06700 7.46078   1.000 32.97260 ? 86  VAL A HG13 1 
ATOM   1302 H HG21 . VAL A 1 86  ? -23.71761 -37.93490 8.84955   1.000 33.99950 ? 86  VAL A HG21 1 
ATOM   1303 H HG22 . VAL A 1 86  ? -24.54631 -36.75515 8.18198   1.000 33.99950 ? 86  VAL A HG22 1 
ATOM   1304 H HG23 . VAL A 1 86  ? -24.45893 -38.16964 7.46414   1.000 33.99950 ? 86  VAL A HG23 1 
ATOM   1305 N N    . LEU A 1 87  ? -22.20552 -38.69010 4.63161   1.000 19.49560 ? 87  LEU A N    1 
ATOM   1306 C CA   . LEU A 1 87  ? -22.27927 -40.07791 4.22573   1.000 26.34899 ? 87  LEU A CA   1 
ATOM   1307 C C    . LEU A 1 87  ? -21.93791 -41.02734 5.35927   1.000 21.60297 ? 87  LEU A C    1 
ATOM   1308 O O    . LEU A 1 87  ? -21.02439 -40.78511 6.16274   1.000 20.81070 ? 87  LEU A O    1 
ATOM   1309 C CB   . LEU A 1 87  ? -21.34765 -40.33144 3.03790   1.000 22.73695 ? 87  LEU A CB   1 
ATOM   1310 H H    . LEU A 1 87  ? -21.41778 -38.34845 4.59510   1.000 23.39472 ? 87  LEU A H    1 
ATOM   1311 H HA   . LEU A 1 87  ? -23.19503 -40.26448 3.96429   1.000 31.61879 ? 87  LEU A HA   1 
ATOM   1312 N N    . LYS A 1 88  ? -22.72009 -42.09301 5.43933   1.000 21.61903 ? 88  LYS A N    1 
ATOM   1313 C CA   . LYS A 1 88  ? -22.54160 -43.14847 6.42175   1.000 22.40879 ? 88  LYS A CA   1 
ATOM   1314 C C    . LYS A 1 88  ? -22.20233 -44.39772 5.63310   1.000 34.59290 ? 88  LYS A C    1 
ATOM   1315 O O    . LYS A 1 88  ? -23.03367 -44.87890 4.84851   1.000 33.17239 ? 88  LYS A O    1 
ATOM   1316 C CB   . LYS A 1 88  ? -23.80074 -43.35700 7.27417   1.000 28.54489 ? 88  LYS A CB   1 
ATOM   1317 C CG   . LYS A 1 88  ? -24.24098 -42.10980 7.99279   1.000 26.82634 ? 88  LYS A CG   1 
ATOM   1318 C CD   . LYS A 1 88  ? -25.20811 -42.43723 9.07624   1.000 31.46580 ? 88  LYS A CD   1 
ATOM   1319 C CE   . LYS A 1 88  ? -26.59874 -42.64700 8.51862   1.000 33.15235 ? 88  LYS A CE   1 
ATOM   1320 N NZ   . LYS A 1 88  ? -27.57213 -42.65246 9.63928   1.000 32.21371 ? 88  LYS A NZ   1 
ATOM   1321 H H    . LYS A 1 88  ? -23.38680 -42.23222 4.91501   1.000 25.94284 ? 88  LYS A H    1 
ATOM   1322 H HA   . LYS A 1 88  ? -21.81899 -42.92628 7.03114   1.000 26.89054 ? 88  LYS A HA   1 
ATOM   1323 H HB2  . LYS A 1 88  ? -24.52631 -43.64122 6.69674   1.000 34.25386 ? 88  LYS A HB2  1 
ATOM   1324 H HB3  . LYS A 1 88  ? -23.61943 -44.03827 7.93982   1.000 34.25386 ? 88  LYS A HB3  1 
ATOM   1325 H HG2  . LYS A 1 88  ? -23.46947 -41.67543 8.39033   1.000 32.19160 ? 88  LYS A HG2  1 
ATOM   1326 H HG3  . LYS A 1 88  ? -24.67324 -41.50975 7.36500   1.000 32.19160 ? 88  LYS A HG3  1 
ATOM   1327 H HD2  . LYS A 1 88  ? -24.93061 -43.25329 9.52084   1.000 37.75896 ? 88  LYS A HD2  1 
ATOM   1328 H HD3  . LYS A 1 88  ? -25.23991 -41.70665 9.71268   1.000 37.75896 ? 88  LYS A HD3  1 
ATOM   1329 H HE2  . LYS A 1 88  ? -26.82310 -41.92580 7.90999   1.000 39.78282 ? 88  LYS A HE2  1 
ATOM   1330 H HE3  . LYS A 1 88  ? -26.64490 -43.49775 8.05608   1.000 39.78282 ? 88  LYS A HE3  1 
ATOM   1331 H HZ1  . LYS A 1 88  ? -28.39794 -42.75593 9.32492   1.000 38.65646 ? 88  LYS A HZ1  1 
ATOM   1332 H HZ2  . LYS A 1 88  ? -27.38980 -43.32166 10.19693  1.000 38.65646 ? 88  LYS A HZ2  1 
ATOM   1333 H HZ3  . LYS A 1 88  ? -27.52690 -41.88470 10.08577  1.000 38.65646 ? 88  LYS A HZ3  1 
ATOM   1334 N N    . LEU A 1 89  ? -20.96201 -44.85281 5.75425   1.000 28.71688 ? 89  LEU A N    1 
ATOM   1335 C CA   . LEU A 1 89  ? -20.46682 -46.02698 5.04970   1.000 28.46641 ? 89  LEU A CA   1 
ATOM   1336 C C    . LEU A 1 89  ? -20.44726 -47.17857 6.03600   1.000 28.50666 ? 89  LEU A C    1 
ATOM   1337 O O    . LEU A 1 89  ? -19.68060 -47.16856 7.00028   1.000 29.14466 ? 89  LEU A O    1 
ATOM   1338 C CB   . LEU A 1 89  ? -19.07682 -45.77652 4.47435   1.000 17.49203 ? 89  LEU A CB   1 
ATOM   1339 C CG   . LEU A 1 89  ? -18.92544 -44.58382 3.54514   1.000 24.43591 ? 89  LEU A CG   1 
ATOM   1340 C CD1  . LEU A 1 89  ? -17.47432 -44.51336 3.04369   1.000 24.17063 ? 89  LEU A CD1  1 
ATOM   1341 C CD2  . LEU A 1 89  ? -19.87596 -44.66486 2.37175   1.000 30.57148 ? 89  LEU A CD2  1 
ATOM   1342 H H    . LEU A 1 89  ? -20.36848 -44.48464 6.25669   1.000 34.46026 ? 89  LEU A H    1 
ATOM   1343 H HA   . LEU A 1 89  ? -21.06039 -46.24500 4.31436   1.000 34.15970 ? 89  LEU A HA   1 
ATOM   1344 H HB2  . LEU A 1 89  ? -18.46619 -45.63749 5.21565   1.000 20.99044 ? 89  LEU A HB2  1 
ATOM   1345 H HB3  . LEU A 1 89  ? -18.81402 -46.56300 3.97096   1.000 20.99044 ? 89  LEU A HB3  1 
ATOM   1346 H HG   . LEU A 1 89  ? -19.14226 -43.77430 4.03356   1.000 29.32309 ? 89  LEU A HG   1 
ATOM   1347 H HD11 . LEU A 1 89  ? -17.40066 -43.79990 2.39016   1.000 29.00475 ? 89  LEU A HD11 1 
ATOM   1348 H HD12 . LEU A 1 89  ? -16.88873 -44.33536 3.79601   1.000 29.00475 ? 89  LEU A HD12 1 
ATOM   1349 H HD13 . LEU A 1 89  ? -17.24050 -45.36092 2.63525   1.000 29.00475 ? 89  LEU A HD13 1 
ATOM   1350 H HD21 . LEU A 1 89  ? -19.74438 -43.88940 1.80428   1.000 36.68578 ? 89  LEU A HD21 1 
ATOM   1351 H HD22 . LEU A 1 89  ? -19.69314 -45.47640 1.87231   1.000 36.68578 ? 89  LEU A HD22 1 
ATOM   1352 H HD23 . LEU A 1 89  ? -20.78707 -44.67979 2.70442   1.000 36.68578 ? 89  LEU A HD23 1 
ATOM   1353 N N    . LYS A 1 90  ? -21.28838 -48.17510 5.80909   1.000 28.22691 ? 90  LYS A N    1 
ATOM   1354 C CA   . LYS A 1 90  ? -21.25476 -49.33961 6.67738   1.000 25.20000 ? 90  LYS A CA   1 
ATOM   1355 C C    . LYS A 1 90  ? -20.05494 -50.20141 6.28027   1.000 29.88229 ? 90  LYS A C    1 
ATOM   1356 O O    . LYS A 1 90  ? -19.89526 -50.53556 5.11012   1.000 32.64398 ? 90  LYS A O    1 
ATOM   1357 C CB   . LYS A 1 90  ? -22.56711 -50.11560 6.58844   1.000 27.65374 ? 90  LYS A CB   1 
ATOM   1358 C CG   . LYS A 1 90  ? -22.64653 -51.28827 7.57369   1.000 36.02900 ? 90  LYS A CG   1 
ATOM   1359 C CD   . LYS A 1 90  ? -23.16835 -50.85252 8.92478   1.000 44.55952 ? 90  LYS A CD   1 
ATOM   1360 C CE   . LYS A 1 90  ? -24.19773 -51.86967 9.45979   1.000 50.47086 ? 90  LYS A CE   1 
ATOM   1361 N NZ   . LYS A 1 90  ? -24.05044 -53.23819 8.87499   1.000 55.26512 ? 90  LYS A NZ   1 
ATOM   1362 H H    . LYS A 1 90  ? -21.87114 -48.20018 5.17687   1.000 33.87229 ? 90  LYS A H    1 
ATOM   1363 H HA   . LYS A 1 90  ? -21.15230 -49.07810 7.60558   1.000 30.24000 ? 90  LYS A HA   1 
ATOM   1364 H HB2  . LYS A 1 90  ? -23.30166 -49.51231 6.78255   1.000 33.18449 ? 90  LYS A HB2  1 
ATOM   1365 H HB3  . LYS A 1 90  ? -22.66051 -50.47212 5.69119   1.000 33.18449 ? 90  LYS A HB3  1 
ATOM   1366 H HG2  . LYS A 1 90  ? -23.24687 -51.96353 7.22006   1.000 43.23480 ? 90  LYS A HG2  1 
ATOM   1367 H HG3  . LYS A 1 90  ? -21.76027 -51.66364 7.69677   1.000 43.23480 ? 90  LYS A HG3  1 
ATOM   1368 H HD2  . LYS A 1 90  ? -22.43262 -50.79732 9.55507   1.000 53.47142 ? 90  LYS A HD2  1 
ATOM   1369 H HD3  . LYS A 1 90  ? -23.60101 -49.98781 8.84316   1.000 53.47142 ? 90  LYS A HD3  1 
ATOM   1370 H HE2  . LYS A 1 90  ? -24.09201 -51.94618 10.42078  1.000 60.56503 ? 90  LYS A HE2  1 
ATOM   1371 H HE3  . LYS A 1 90  ? -25.08991 -51.55225 9.24867   1.000 60.56503 ? 90  LYS A HE3  1 
ATOM   1372 H HZ1  . LYS A 1 90  ? -24.62213 -53.79889 9.26345   1.000 66.31815 ? 90  LYS A HZ1  1 
ATOM   1373 H HZ2  . LYS A 1 90  ? -24.21715 -53.21479 8.00095   1.000 66.31815 ? 90  LYS A HZ2  1 
ATOM   1374 H HZ3  . LYS A 1 90  ? -23.22125 -53.53561 9.00210   1.000 66.31815 ? 90  LYS A HZ3  1 
ATOM   1375 N N    . VAL A 1 91  ? -19.19801 -50.54533 7.25537   1.000 31.22354 ? 91  VAL A N    1 
ATOM   1376 C CA   . VAL A 1 91  ? -17.98730 -51.31821 6.99932   1.000 31.97621 ? 91  VAL A CA   1 
ATOM   1377 C C    . VAL A 1 91  ? -18.13552 -52.63480 7.76645   1.000 30.74637 ? 91  VAL A C    1 
ATOM   1378 O O    . VAL A 1 91  ? -18.93177 -52.73301 8.69811   1.000 30.78403 ? 91  VAL A O    1 
ATOM   1379 C CB   . VAL A 1 91  ? -16.70604 -50.57345 7.43023   1.000 33.90787 ? 91  VAL A CB   1 
ATOM   1380 C CG1  . VAL A 1 91  ? -16.40362 -49.41862 6.46305   1.000 32.03772 ? 91  VAL A CG1  1 
ATOM   1381 C CG2  . VAL A 1 91  ? -16.77492 -50.11340 8.87849   1.000 30.63288 ? 91  VAL A CG2  1 
ATOM   1382 H H    . VAL A 1 91  ? -19.30446 -50.33692 8.08246   1.000 37.46824 ? 91  VAL A H    1 
ATOM   1383 H HA   . VAL A 1 91  ? -17.90182 -51.50256 6.05123   1.000 38.37145 ? 91  VAL A HA   1 
ATOM   1384 H HB   . VAL A 1 91  ? -15.96054 -51.19283 7.38611   1.000 40.68945 ? 91  VAL A HB   1 
ATOM   1385 H HG11 . VAL A 1 91  ? -15.56304 -49.00610 6.71660   1.000 38.44526 ? 91  VAL A HG11 1 
ATOM   1386 H HG12 . VAL A 1 91  ? -16.34102 -49.77001 5.56085   1.000 38.44526 ? 91  VAL A HG12 1 
ATOM   1387 H HG13 . VAL A 1 91  ? -17.12016 -48.76722 6.51519   1.000 38.44526 ? 91  VAL A HG13 1 
ATOM   1388 H HG21 . VAL A 1 91  ? -15.93635 -49.68588 9.11405   1.000 36.75945 ? 91  VAL A HG21 1 
ATOM   1389 H HG22 . VAL A 1 91  ? -17.50646 -49.48304 8.97462   1.000 36.75945 ? 91  VAL A HG22 1 
ATOM   1390 H HG23 . VAL A 1 91  ? -16.92451 -50.88387 9.44796   1.000 36.75945 ? 91  VAL A HG23 1 
ATOM   1391 N N    . ASP A 1 92  ? -17.35059 -53.64294 7.38711   1.000 33.51332 ? 92  ASP A N    1 
ATOM   1392 C CA   . ASP A 1 92  ? -17.56570 -54.99444 7.91320   1.000 37.57466 ? 92  ASP A CA   1 
ATOM   1393 C C    . ASP A 1 92  ? -16.93201 -55.21278 9.28129   1.000 40.32518 ? 92  ASP A C    1 
ATOM   1394 O O    . ASP A 1 92  ? -17.25044 -56.21643 9.93056   1.000 34.97310 ? 92  ASP A O    1 
ATOM   1395 C CB   . ASP A 1 92  ? -17.05851 -56.01739 6.85875   1.000 37.54037 ? 92  ASP A CB   1 
ATOM   1396 C CG   . ASP A 1 92  ? -15.52739 -56.13512 6.78521   1.000 41.87146 ? 92  ASP A CG   1 
ATOM   1397 O OD1  . ASP A 1 92  ? -14.80228 -55.21482 7.22704   1.000 47.45038 ? 92  ASP A OD1  1 
ATOM   1398 O OD2  . ASP A 1 92  ? -15.04038 -57.12435 6.16978   1.000 55.47226 ? 92  ASP A OD2  1 
ATOM   1399 H H    . ASP A 1 92  ? -16.69645 -53.57408 6.83338   1.000 40.21599 ? 92  ASP A H    1 
ATOM   1400 H HA   . ASP A 1 92  ? -18.51161 -55.16227 8.04376   1.000 45.08959 ? 92  ASP A HA   1 
ATOM   1401 H HB2  . ASP A 1 92  ? -17.41089 -56.89380 7.08108   1.000 45.04844 ? 92  ASP A HB2  1 
ATOM   1402 H HB3  . ASP A 1 92  ? -17.37542 -55.74510 5.98380   1.000 45.04844 ? 92  ASP A HB3  1 
ATOM   1403 N N    . THR A 1 93  ? -16.12893 -54.25943 9.76116   1.000 33.89498 ? 93  THR A N    1 
ATOM   1404 C CA   . THR A 1 93  ? -15.36830 -54.34860 11.00837  1.000 33.75358 ? 93  THR A CA   1 
ATOM   1405 C C    . THR A 1 93  ? -15.75754 -53.21949 11.95193  1.000 38.30752 ? 93  THR A C    1 
ATOM   1406 O O    . THR A 1 93  ? -15.83331 -52.05729 11.53662  1.000 35.31822 ? 93  THR A O    1 
ATOM   1407 C CB   . THR A 1 93  ? -13.86527 -54.26323 10.73096  1.000 33.78062 ? 93  THR A CB   1 
ATOM   1408 O OG1  . THR A 1 93  ? -13.56829 -54.96224 9.51763   1.000 46.69745 ? 93  THR A OG1  1 
ATOM   1409 C CG2  . THR A 1 93  ? -13.00226 -54.78725 11.88594  1.000 39.89429 ? 93  THR A CG2  1 
ATOM   1410 H H    . THR A 1 93  ? -16.00239 -53.50908 9.35867   1.000 40.67398 ? 93  THR A H    1 
ATOM   1411 H HA   . THR A 1 93  ? -15.57978 -55.19303 11.43778  1.000 40.50430 ? 93  THR A HA   1 
ATOM   1412 H HB   . THR A 1 93  ? -13.62598 -53.32798 10.63762  1.000 40.53674 ? 93  THR A HB   1 
ATOM   1413 H HG1  . THR A 1 93  ? -12.77132 -54.82147 9.29200   1.000 56.03694 ? 93  THR A HG1  1 
ATOM   1414 H HG21 . THR A 1 93  ? -12.06127 -54.68437 11.67033  1.000 47.87315 ? 93  THR A HG21 1 
ATOM   1415 H HG22 . THR A 1 93  ? -13.19594 -54.29191 12.69617  1.000 47.87315 ? 93  THR A HG22 1 
ATOM   1416 H HG23 . THR A 1 93  ? -13.18757 -55.72750 12.03929  1.000 47.87315 ? 93  THR A HG23 1 
ATOM   1417 N N    . ALA A 1 94  ? -15.99471 -53.56445 13.21464  1.000 27.99460 ? 94  ALA A N    1 
ATOM   1418 C CA   . ALA A 1 94  ? -16.18387 -52.57425 14.25918  1.000 29.13298 ? 94  ALA A CA   1 
ATOM   1419 C C    . ALA A 1 94  ? -14.82044 -52.03442 14.67599  1.000 32.28656 ? 94  ALA A C    1 
ATOM   1420 O O    . ALA A 1 94  ? -13.88091 -52.80281 14.89285  1.000 32.21152 ? 94  ALA A O    1 
ATOM   1421 C CB   . ALA A 1 94  ? -16.91079 -53.19856 15.45154  1.000 29.59989 ? 94  ALA A CB   1 
ATOM   1422 H H    . ALA A 1 94  ? -16.05016 -54.37667 13.49112  1.000 33.59352 ? 94  ALA A H    1 
ATOM   1423 H HA   . ALA A 1 94  ? -16.72734 -51.83748 13.93744  1.000 34.95958 ? 94  ALA A HA   1 
ATOM   1424 H HB1  . ALA A 1 94  ? -16.97857 -52.53905 16.15992  1.000 35.51987 ? 94  ALA A HB1  1 
ATOM   1425 H HB2  . ALA A 1 94  ? -17.79647 -53.47509 15.17206  1.000 35.51987 ? 94  ALA A HB2  1 
ATOM   1426 H HB3  . ALA A 1 94  ? -16.40629 -53.96635 15.76124  1.000 35.51987 ? 94  ALA A HB3  1 
ATOM   1427 N N    . ASN A 1 95  ? -14.70352 -50.72037 14.75485  1.000 33.22725 ? 95  ASN A N    1 
ATOM   1428 C CA   . ASN A 1 95  ? -13.46217 -50.10467 15.21266  1.000 29.62385 ? 95  ASN A CA   1 
ATOM   1429 C C    . ASN A 1 95  ? -13.11427 -50.59826 16.61548  1.000 30.04681 ? 95  ASN A C    1 
ATOM   1430 O O    . ASN A 1 95  ? -13.87181 -50.33544 17.55738  1.000 27.39303 ? 95  ASN A O    1 
ATOM   1431 C CB   . ASN A 1 95  ? -13.62935 -48.58976 15.14554  1.000 25.68314 ? 95  ASN A CB   1 
ATOM   1432 C CG   . ASN A 1 95  ? -12.35605 -47.85394 15.46644  1.000 30.50079 ? 95  ASN A CG   1 
ATOM   1433 O OD1  . ASN A 1 95  ? -11.38674 -48.44145 15.91442  1.000 26.89830 ? 95  ASN A OD1  1 
ATOM   1434 N ND2  . ASN A 1 95  ? -12.34800 -46.53878 15.20726  1.000 35.94473 ? 95  ASN A ND2  1 
ATOM   1435 H H    . ASN A 1 95  ? -15.32389 -50.16074 14.55097  1.000 39.87270 ? 95  ASN A H    1 
ATOM   1436 H HA   . ASN A 1 95  ? -12.71377 -50.34972 14.64778  1.000 35.54863 ? 95  ASN A HA   1 
ATOM   1437 H HB2  . ASN A 1 95  ? -13.90223 -48.34042 14.24860  1.000 30.81977 ? 95  ASN A HB2  1 
ATOM   1438 H HB3  . ASN A 1 95  ? -14.30379 -48.31569 15.78547  1.000 30.81977 ? 95  ASN A HB3  1 
ATOM   1439 H HD21 . ASN A 1 95  ? -11.64443 -46.07332 15.37279  1.000 43.13367 ? 95  ASN A HD21 1 
ATOM   1440 H HD22 . ASN A 1 95  ? -13.04619 -46.16213 14.87524  1.000 43.13367 ? 95  ASN A HD22 1 
ATOM   1441 N N    . PRO A 1 96  ? -12.01574 -51.34449 16.78741  1.000 27.01857 ? 96  PRO A N    1 
ATOM   1442 C CA   . PRO A 1 96  ? -11.63987 -51.77702 18.14528  1.000 28.72290 ? 96  PRO A CA   1 
ATOM   1443 C C    . PRO A 1 96  ? -11.38512 -50.62641 19.09408  1.000 32.88079 ? 96  PRO A C    1 
ATOM   1444 O O    . PRO A 1 96  ? -11.42538 -50.84519 20.31193  1.000 29.77538 ? 96  PRO A O    1 
ATOM   1445 C CB   . PRO A 1 96  ? -10.37112 -52.62088 17.92120  1.000 29.63396 ? 96  PRO A CB   1 
ATOM   1446 C CG   . PRO A 1 96  ? -9.81302  -52.16862 16.60568  1.000 25.48893 ? 96  PRO A CG   1 
ATOM   1447 C CD   . PRO A 1 96  ? -11.02704 -51.76707 15.76950  1.000 25.16767 ? 96  PRO A CD   1 
ATOM   1448 H HA   . PRO A 1 96  ? -12.33255 -52.34780 18.51268  1.000 34.46747 ? 96  PRO A HA   1 
ATOM   1449 H HB2  . PRO A 1 96  ? -9.73850  -52.45682 18.63853  1.000 35.56076 ? 96  PRO A HB2  1 
ATOM   1450 H HB3  . PRO A 1 96  ? -10.60436 -53.56105 17.89254  1.000 35.56076 ? 96  PRO A HB3  1 
ATOM   1451 H HG2  . PRO A 1 96  ? -9.22166  -51.41323 16.74035  1.000 30.58671 ? 96  PRO A HG2  1 
ATOM   1452 H HG3  . PRO A 1 96  ? -9.33029  -52.89798 16.18540  1.000 30.58671 ? 96  PRO A HG3  1 
ATOM   1453 H HD2  . PRO A 1 96  ? -10.80841 -51.03353 15.17503  1.000 30.20121 ? 96  PRO A HD2  1 
ATOM   1454 H HD3  . PRO A 1 96  ? -11.35926 -52.52202 15.25791  1.000 30.20121 ? 96  PRO A HD3  1 
ATOM   1455 N N    . LYS A 1 97  ? -11.17191 -49.41092 18.57690  1.000 34.70042 ? 97  LYS A N    1 
ATOM   1456 C CA   . LYS A 1 97  ? -10.82013 -48.22511 19.35276  1.000 26.81544 ? 97  LYS A CA   1 
ATOM   1457 C C    . LYS A 1 97  ? -12.01195 -47.28520 19.57091  1.000 36.81226 ? 97  LYS A C    1 
ATOM   1458 O O    . LYS A 1 97  ? -11.82601 -46.15233 20.02068  1.000 34.72189 ? 97  LYS A O    1 
ATOM   1459 C CB   . LYS A 1 97  ? -9.68848  -47.47479 18.66362  1.000 33.79949 ? 97  LYS A CB   1 
ATOM   1460 C CG   . LYS A 1 97  ? -8.57558  -48.35757 18.12447  1.000 31.37917 ? 97  LYS A CG   1 
ATOM   1461 C CD   . LYS A 1 97  ? -7.22120  -47.62755 18.21839  1.000 34.07156 ? 97  LYS A CD   1 
ATOM   1462 C CE   . LYS A 1 97  ? -6.06336  -48.38021 17.53934  1.000 39.68961 ? 97  LYS A CE   1 
ATOM   1463 N NZ   . LYS A 1 97  ? -5.75118  -47.98009 16.12469  1.000 47.96648 ? 97  LYS A NZ   1 
ATOM   1464 H H    . LYS A 1 97  ? -11.22774 -49.24444 17.73498  1.000 41.64050 ? 97  LYS A H    1 
ATOM   1465 H HA   . LYS A 1 97  ? -10.50821 -48.50840 20.22669  1.000 32.17853 ? 97  LYS A HA   1 
ATOM   1466 H HB2  . LYS A 1 97  ? -10.05861 -46.98062 17.91479  1.000 40.55939 ? 97  LYS A HB2  1 
ATOM   1467 H HB3  . LYS A 1 97  ? -9.29219  -46.86187 19.30214  1.000 40.55939 ? 97  LYS A HB3  1 
ATOM   1468 H HG2  . LYS A 1 97  ? -8.52512  -49.17385 18.64598  1.000 37.65500 ? 97  LYS A HG2  1 
ATOM   1469 H HG3  . LYS A 1 97  ? -8.74909  -48.56813 17.19327  1.000 37.65500 ? 97  LYS A HG3  1 
ATOM   1470 H HD2  . LYS A 1 97  ? -7.30174  -46.76135 17.79090  1.000 40.88587 ? 97  LYS A HD2  1 
ATOM   1471 H HD3  . LYS A 1 97  ? -6.99162  -47.51494 19.15454  1.000 40.88587 ? 97  LYS A HD3  1 
ATOM   1472 H HE2  . LYS A 1 97  ? -5.25966  -48.23289 18.06171  1.000 47.62754 ? 97  LYS A HE2  1 
ATOM   1473 H HE3  . LYS A 1 97  ? -6.28260  -49.32538 17.52668  1.000 47.62754 ? 97  LYS A HE3  1 
ATOM   1474 H HZ1  . LYS A 1 97  ? -5.09066  -48.48337 15.80462  1.000 57.55977 ? 97  LYS A HZ1  1 
ATOM   1475 H HZ2  . LYS A 1 97  ? -6.47091  -48.08735 15.61137  1.000 57.55977 ? 97  LYS A HZ2  1 
ATOM   1476 H HZ3  . LYS A 1 97  ? -5.50285  -47.12587 16.09731  1.000 57.55977 ? 97  LYS A HZ3  1 
ATOM   1477 N N    . THR A 1 98  ? -13.22450 -47.69995 19.21923  1.000 37.12631 ? 98  THR A N    1 
ATOM   1478 C CA   . THR A 1 98  ? -14.38525 -46.87104 19.49233  1.000 26.99708 ? 98  THR A CA   1 
ATOM   1479 C C    . THR A 1 98  ? -14.46605 -46.52501 20.96952  1.000 31.46993 ? 98  THR A C    1 
ATOM   1480 O O    . THR A 1 98  ? -14.67264 -47.41470 21.81290  1.000 27.89303 ? 98  THR A O    1 
ATOM   1481 C CB   . THR A 1 98  ? -15.68157 -47.55081 19.07446  1.000 31.01161 ? 98  THR A CB   1 
ATOM   1482 O OG1  . THR A 1 98  ? -15.57574 -47.99490 17.72822  1.000 31.20208 ? 98  THR A OG1  1 
ATOM   1483 C CG2  . THR A 1 98  ? -16.89337 -46.60587 19.22561  1.000 32.17223 ? 98  THR A CG2  1 
ATOM   1484 H H    . THR A 1 98  ? -13.39476 -48.44684 18.82671  1.000 44.55158 ? 98  THR A H    1 
ATOM   1485 H HA   . THR A 1 98  ? -14.28272 -46.05564 18.97687  1.000 32.39649 ? 98  THR A HA   1 
ATOM   1486 H HB   . THR A 1 98  ? -15.83916 -48.31330 19.65393  1.000 37.21394 ? 98  THR A HB   1 
ATOM   1487 H HG1  . THR A 1 98  ? -15.58506 -48.83489 17.70170  1.000 37.44249 ? 98  THR A HG1  1 
ATOM   1488 H HG21 . THR A 1 98  ? -17.54798 -46.79397 18.53426  1.000 38.60668 ? 98  THR A HG21 1 
ATOM   1489 H HG22 . THR A 1 98  ? -17.30658 -46.73273 20.09339  1.000 38.60668 ? 98  THR A HG22 1 
ATOM   1490 H HG23 . THR A 1 98  ? -16.60608 -45.68259 19.14428  1.000 38.60668 ? 98  THR A HG23 1 
ATOM   1491 N N    . PRO A 1 99  ? -14.34819 -45.24213 21.30735  1.000 27.86838 ? 99  PRO A N    1 
ATOM   1492 C CA   . PRO A 1 99  ? -14.54403 -44.80013 22.69055  1.000 29.66148 ? 99  PRO A CA   1 
ATOM   1493 C C    . PRO A 1 99  ? -16.02914 -44.80051 22.99703  1.000 24.65035 ? 99  PRO A C    1 
ATOM   1494 O O    . PRO A 1 99  ? -16.86267 -44.99262 22.10762  1.000 32.08929 ? 99  PRO A O    1 
ATOM   1495 C CB   . PRO A 1 99  ? -13.97016 -43.37767 22.68563  1.000 27.43784 ? 99  PRO A CB   1 
ATOM   1496 C CG   . PRO A 1 99  ? -14.32307 -42.88010 21.29582  1.000 30.82480 ? 99  PRO A CG   1 
ATOM   1497 C CD   . PRO A 1 99  ? -14.17677 -44.10741 20.37511  1.000 32.62283 ? 99  PRO A CD   1 
ATOM   1498 H HA   . PRO A 1 99  ? -14.05383 -45.33614 23.33340  1.000 35.59378 ? 99  PRO A HA   1 
ATOM   1499 H HB2  . PRO A 1 99  ? -14.39183 -42.83943 23.37382  1.000 32.92540 ? 99  PRO A HB2  1 
ATOM   1500 H HB3  . PRO A 1 99  ? -13.01019 -43.39799 22.82296  1.000 32.92540 ? 99  PRO A HB3  1 
ATOM   1501 H HG2  . PRO A 1 99  ? -15.23433 -42.54782 21.28670  1.000 36.98976 ? 99  PRO A HG2  1 
ATOM   1502 H HG3  . PRO A 1 99  ? -13.71054 -42.17545 21.03347  1.000 36.98976 ? 99  PRO A HG3  1 
ATOM   1503 H HD2  . PRO A 1 99  ? -14.86552 -44.11254 19.69286  1.000 39.14740 ? 99  PRO A HD2  1 
ATOM   1504 H HD3  . PRO A 1 99  ? -13.29960 -44.12746 19.96241  1.000 39.14740 ? 99  PRO A HD3  1 
ATOM   1505 N N    . LYS A 1 100 ? -16.36076 -44.59255 24.26904  1.000 33.80805 ? 100 LYS A N    1 
ATOM   1506 C CA   . LYS A 1 100 ? -17.72918 -44.20384 24.59580  1.000 29.30807 ? 100 LYS A CA   1 
ATOM   1507 C C    . LYS A 1 100 ? -18.01902 -42.86367 23.94052  1.000 33.38973 ? 100 LYS A C    1 
ATOM   1508 O O    . LYS A 1 100 ? -17.23782 -41.91514 24.08238  1.000 30.33093 ? 100 LYS A O    1 
ATOM   1509 C CB   . LYS A 1 100 ? -17.97481 -44.07396 26.09579  1.000 37.21846 ? 100 LYS A CB   1 
ATOM   1510 C CG   . LYS A 1 100 ? -18.10279 -45.38425 26.81447  1.000 39.68952 ? 100 LYS A CG   1 
ATOM   1511 C CD   . LYS A 1 100 ? -17.46679 -45.29767 28.19568  1.000 45.22788 ? 100 LYS A CD   1 
ATOM   1512 C CE   . LYS A 1 100 ? -17.32249 -46.65840 28.80949  1.000 42.41258 ? 100 LYS A CE   1 
ATOM   1513 N NZ   . LYS A 1 100 ? -15.90340 -47.03626 28.83558  1.000 51.94015 ? 100 LYS A NZ   1 
ATOM   1514 H H    . LYS A 1 100 ? -15.82893 -44.66754 24.94018  1.000 40.56966 ? 100 LYS A H    1 
ATOM   1515 H HA   . LYS A 1 100 ? -18.32351 -44.90012 24.27516  1.000 35.16969 ? 100 LYS A HA   1 
ATOM   1516 H HB2  . LYS A 1 100 ? -17.23060 -43.59253 26.49061  1.000 44.66215 ? 100 LYS A HB2  1 
ATOM   1517 H HB3  . LYS A 1 100 ? -18.79889 -43.58092 26.23307  1.000 44.66215 ? 100 LYS A HB3  1 
ATOM   1518 H HG2  . LYS A 1 100 ? -19.04053 -45.60684 26.91834  1.000 47.62743 ? 100 LYS A HG2  1 
ATOM   1519 H HG3  . LYS A 1 100 ? -17.65120 -46.07770 26.30861  1.000 47.62743 ? 100 LYS A HG3  1 
ATOM   1520 H HD2  . LYS A 1 100 ? -16.58510 -44.90052 28.12108  1.000 54.27346 ? 100 LYS A HD2  1 
ATOM   1521 H HD3  . LYS A 1 100 ? -18.02539 -44.75748 28.77568  1.000 54.27346 ? 100 LYS A HD3  1 
ATOM   1522 H HE2  . LYS A 1 100 ? -17.66120 -46.64623 29.71858  1.000 50.89510 ? 100 LYS A HE2  1 
ATOM   1523 H HE3  . LYS A 1 100 ? -17.81059 -47.30922 28.28188  1.000 50.89510 ? 100 LYS A HE3  1 
ATOM   1524 H HZ1  . LYS A 1 100 ? -15.80978 -47.84326 29.19950  1.000 62.32818 ? 100 LYS A HZ1  1 
ATOM   1525 H HZ2  . LYS A 1 100 ? -15.57719 -47.05283 28.00772  1.000 62.32818 ? 100 LYS A HZ2  1 
ATOM   1526 H HZ3  . LYS A 1 100 ? -15.44023 -46.44775 29.31655  1.000 62.32818 ? 100 LYS A HZ3  1 
ATOM   1527 N N    . TYR A 1 101 ? -19.14485 -42.76514 23.25219  1.000 28.02302 ? 101 TYR A N    1 
ATOM   1528 C CA   . TYR A 1 101 ? -19.39857 -41.53790 22.52885  1.000 26.69459 ? 101 TYR A CA   1 
ATOM   1529 C C    . TYR A 1 101 ? -20.87677 -41.24401 22.42451  1.000 31.22420 ? 101 TYR A C    1 
ATOM   1530 O O    . TYR A 1 101 ? -21.73610 -42.13076 22.53366  1.000 30.08643 ? 101 TYR A O    1 
ATOM   1531 C CB   . TYR A 1 101 ? -18.80601 -41.61756 21.12101  1.000 23.59007 ? 101 TYR A CB   1 
ATOM   1532 C CG   . TYR A 1 101 ? -19.55698 -42.47655 20.14022  1.000 23.93450 ? 101 TYR A CG   1 
ATOM   1533 C CD1  . TYR A 1 101 ? -20.59213 -41.95891 19.38717  1.000 32.83203 ? 101 TYR A CD1  1 
ATOM   1534 C CD2  . TYR A 1 101 ? -19.22286 -43.81019 19.97851  1.000 30.03348 ? 101 TYR A CD2  1 
ATOM   1535 C CE1  . TYR A 1 101 ? -21.26518 -42.73588 18.45945  1.000 28.39548 ? 101 TYR A CE1  1 
ATOM   1536 C CE2  . TYR A 1 101 ? -19.88390 -44.60815 19.05579  1.000 26.98216 ? 101 TYR A CE2  1 
ATOM   1537 C CZ   . TYR A 1 101 ? -20.90206 -44.07049 18.29876  1.000 27.79234 ? 101 TYR A CZ   1 
ATOM   1538 O OH   . TYR A 1 101 ? -21.56811 -44.86547 17.39903  1.000 34.98172 ? 101 TYR A OH   1 
ATOM   1539 H H    . TYR A 1 101 ? -19.75135 -43.37159 23.19360  1.000 33.62762 ? 101 TYR A H    1 
ATOM   1540 H HA   . TYR A 1 101 ? -19.00233 -40.80989 23.03244  1.000 32.03350 ? 101 TYR A HA   1 
ATOM   1541 H HB2  . TYR A 1 101 ? -18.77660 -40.72031 20.75358  1.000 28.30808 ? 101 TYR A HB2  1 
ATOM   1542 H HB3  . TYR A 1 101 ? -17.90775 -41.97789 21.19011  1.000 28.30808 ? 101 TYR A HB3  1 
ATOM   1543 H HD1  . TYR A 1 101 ? -20.84188 -41.07118 19.50463  1.000 39.39844 ? 101 TYR A HD1  1 
ATOM   1544 H HD2  . TYR A 1 101 ? -18.54475 -44.17797 20.49753  1.000 36.04017 ? 101 TYR A HD2  1 
ATOM   1545 H HE1  . TYR A 1 101 ? -21.95229 -42.37111 17.94944  1.000 34.07457 ? 101 TYR A HE1  1 
ATOM   1546 H HE2  . TYR A 1 101 ? -19.64115 -45.49989 18.94832  1.000 32.37859 ? 101 TYR A HE2  1 
ATOM   1547 H HH   . TYR A 1 101 ? -21.12350 -45.56202 17.24676  1.000 41.97806 ? 101 TYR A HH   1 
ATOM   1548 N N    . LYS A 1 102 ? -21.14470 -39.96507 22.17721  1.000 33.46146 ? 102 LYS A N    1 
ATOM   1549 C CA   . LYS A 1 102 ? -22.45800 -39.44692 21.85906  1.000 27.51209 ? 102 LYS A CA   1 
ATOM   1550 C C    . LYS A 1 102 ? -22.27535 -38.49406 20.69171  1.000 28.40253 ? 102 LYS A C    1 
ATOM   1551 O O    . LYS A 1 102 ? -21.19472 -37.93407 20.49344  1.000 24.54846 ? 102 LYS A O    1 
ATOM   1552 C CB   . LYS A 1 102 ? -23.08902 -38.68214 23.02231  1.000 24.52996 ? 102 LYS A CB   1 
ATOM   1553 C CG   . LYS A 1 102 ? -23.39481 -39.50316 24.27470  1.000 41.34271 ? 102 LYS A CG   1 
ATOM   1554 C CD   . LYS A 1 102 ? -24.65147 -38.97857 24.94058  1.000 42.03734 ? 102 LYS A CD   1 
ATOM   1555 C CE   . LYS A 1 102 ? -24.34140 -38.41417 26.32104  1.000 51.02899 ? 102 LYS A CE   1 
ATOM   1556 N NZ   . LYS A 1 102 ? -25.36242 -38.83060 27.32242  1.000 57.90137 ? 102 LYS A NZ   1 
ATOM   1557 H H    . LYS A 1 102 ? -20.54620 -39.34860 22.19080  1.000 40.15375 ? 102 LYS A H    1 
ATOM   1558 H HA   . LYS A 1 102 ? -23.05434 -40.17725 21.63040  1.000 33.01450 ? 102 LYS A HA   1 
ATOM   1559 H HB2  . LYS A 1 102 ? -22.48068 -37.97382 23.28496  1.000 29.43595 ? 102 LYS A HB2  1 
ATOM   1560 H HB3  . LYS A 1 102 ? -23.92822 -38.30262 22.71625  1.000 29.43595 ? 102 LYS A HB3  1 
ATOM   1561 H HG2  . LYS A 1 102 ? -23.53599 -40.43212 24.03107  1.000 49.61125 ? 102 LYS A HG2  1 
ATOM   1562 H HG3  . LYS A 1 102 ? -22.65709 -39.43295 24.90000  1.000 49.61125 ? 102 LYS A HG3  1 
ATOM   1563 H HD2  . LYS A 1 102 ? -25.03384 -38.27054 24.39888  1.000 50.44481 ? 102 LYS A HD2  1 
ATOM   1564 H HD3  . LYS A 1 102 ? -25.28993 -39.70114 25.04091  1.000 50.44481 ? 102 LYS A HD3  1 
ATOM   1565 H HE2  . LYS A 1 102 ? -23.47525 -38.73966 26.61414  1.000 61.23479 ? 102 LYS A HE2  1 
ATOM   1566 H HE3  . LYS A 1 102 ? -24.33316 -37.44514 26.27764  1.000 61.23479 ? 102 LYS A HE3  1 
ATOM   1567 H HZ1  . LYS A 1 102 ? -25.15597 -38.50293 28.12269  1.000 69.48165 ? 102 LYS A HZ1  1 
ATOM   1568 H HZ2  . LYS A 1 102 ? -26.16458 -38.52509 27.08432  1.000 69.48165 ? 102 LYS A HZ2  1 
ATOM   1569 H HZ3  . LYS A 1 102 ? -25.39474 -39.71866 27.37286  1.000 69.48165 ? 102 LYS A HZ3  1 
ATOM   1570 N N    . PHE A 1 103 ? -23.33724 -38.29143 19.93546  1.000 24.19920 ? 103 PHE A N    1 
ATOM   1571 C CA   . PHE A 1 103 ? -23.43278 -37.19792 18.98510  1.000 23.36621 ? 103 PHE A CA   1 
ATOM   1572 C C    . PHE A 1 103 ? -24.23190 -36.05293 19.59153  1.000 24.95080 ? 103 PHE A C    1 
ATOM   1573 O O    . PHE A 1 103 ? -25.34990 -36.27713 20.08300  1.000 26.26947 ? 103 PHE A O    1 
ATOM   1574 C CB   . PHE A 1 103 ? -24.08393 -37.67563 17.66958  1.000 21.30059 ? 103 PHE A CB   1 
ATOM   1575 C CG   . PHE A 1 103 ? -23.24389 -38.60244 16.81330  1.000 19.68195 ? 103 PHE A CG   1 
ATOM   1576 C CD1  . PHE A 1 103 ? -21.89279 -38.83251 17.04864  1.000 25.10102 ? 103 PHE A CD1  1 
ATOM   1577 C CD2  . PHE A 1 103 ? -23.81903 -39.19721 15.70873  1.000 23.67972 ? 103 PHE A CD2  1 
ATOM   1578 C CE1  . PHE A 1 103 ? -21.14985 -39.64540 16.20640  1.000 20.96260 ? 103 PHE A CE1  1 
ATOM   1579 C CE2  . PHE A 1 103 ? -23.07208 -40.00810 14.86250  1.000 23.06962 ? 103 PHE A CE2  1 
ATOM   1580 C CZ   . PHE A 1 103 ? -21.74199 -40.24120 15.11782  1.000 25.94673 ? 103 PHE A CZ   1 
ATOM   1581 H H    . PHE A 1 103 ? -24.03885 -38.78900 19.95391  1.000 29.03904 ? 103 PHE A H    1 
ATOM   1582 H HA   . PHE A 1 103 ? -22.54297 -36.86709 18.78362  1.000 28.03946 ? 103 PHE A HA   1 
ATOM   1583 H HB2  . PHE A 1 103 ? -24.90063 -38.15042 17.88900  1.000 25.56071 ? 103 PHE A HB2  1 
ATOM   1584 H HB3  . PHE A 1 103 ? -24.28836 -36.89446 17.13099  1.000 25.56071 ? 103 PHE A HB3  1 
ATOM   1585 H HD1  . PHE A 1 103 ? -21.48137 -38.43563 17.78203  1.000 30.12123 ? 103 PHE A HD1  1 
ATOM   1586 H HD2  . PHE A 1 103 ? -24.72008 -39.05382 15.52850  1.000 28.41566 ? 103 PHE A HD2  1 
ATOM   1587 H HE1  . PHE A 1 103 ? -20.24679 -39.78778 16.37863  1.000 25.15512 ? 103 PHE A HE1  1 
ATOM   1588 H HE2  . PHE A 1 103 ? -23.47551 -40.39496 14.11912  1.000 27.68355 ? 103 PHE A HE2  1 
ATOM   1589 H HZ   . PHE A 1 103 ? -21.24735 -40.79746 14.55965  1.000 31.13608 ? 103 PHE A HZ   1 
ATOM   1590 N N    . VAL A 1 104 ? -23.69487 -34.84350 19.59046  1.000 21.45656 ? 104 VAL A N    1 
ATOM   1591 C CA   . VAL A 1 104 ? -24.47294 -33.70543 20.08089  1.000 21.52821 ? 104 VAL A CA   1 
ATOM   1592 C C    . VAL A 1 104 ? -24.45254 -32.52981 19.11662  1.000 29.60062 ? 104 VAL A C    1 
ATOM   1593 O O    . VAL A 1 104 ? -23.45451 -32.26060 18.43014  1.000 26.11158 ? 104 VAL A O    1 
ATOM   1594 C CB   . VAL A 1 104 ? -23.97380 -33.24088 21.46035  1.000 31.86556 ? 104 VAL A CB   1 
ATOM   1595 C CG1  . VAL A 1 104 ? -23.91721 -34.40342 22.41766  1.000 23.09315 ? 104 VAL A CG1  1 
ATOM   1596 C CG2  . VAL A 1 104 ? -22.59827 -32.59870 21.33223  1.000 37.14982 ? 104 VAL A CG2  1 
ATOM   1597 H H    . VAL A 1 104 ? -22.90092 -34.65570 19.31786  1.000 25.74787 ? 104 VAL A H    1 
ATOM   1598 H HA   . VAL A 1 104 ? -25.39372 -34.00419 20.13038  1.000 25.83385 ? 104 VAL A HA   1 
ATOM   1599 H HB   . VAL A 1 104 ? -24.59145 -32.58259 21.81554  1.000 38.23867 ? 104 VAL A HB   1 
ATOM   1600 H HG11 . VAL A 1 104 ? -23.73380 -34.06983 23.30993  1.000 27.71178 ? 104 VAL A HG11 1 
ATOM   1601 H HG12 . VAL A 1 104 ? -24.77084 -34.86410 22.40607  1.000 27.71178 ? 104 VAL A HG12 1 
ATOM   1602 H HG13 . VAL A 1 104 ? -23.21163 -35.00769 22.13853  1.000 27.71178 ? 104 VAL A HG13 1 
ATOM   1603 H HG21 . VAL A 1 104 ? -22.13852 -32.66286 22.18436  1.000 44.57979 ? 104 VAL A HG21 1 
ATOM   1604 H HG22 . VAL A 1 104 ? -22.09365 -33.06788 20.64912  1.000 44.57979 ? 104 VAL A HG22 1 
ATOM   1605 H HG23 . VAL A 1 104 ? -22.70592 -31.66764 21.08277  1.000 44.57979 ? 104 VAL A HG23 1 
ATOM   1606 N N    . ARG A 1 105 ? -25.56311 -31.80669 19.09468  1.000 23.42106 ? 105 ARG A N    1 
ATOM   1607 C CA   . ARG A 1 105 ? -25.67189 -30.53236 18.42842  1.000 27.33875 ? 105 ARG A CA   1 
ATOM   1608 C C    . ARG A 1 105 ? -25.43813 -29.43080 19.45119  1.000 26.15597 ? 105 ARG A C    1 
ATOM   1609 O O    . ARG A 1 105 ? -26.29865 -29.14800 20.28706  1.000 32.14274 ? 105 ARG A O    1 
ATOM   1610 C CB   . ARG A 1 105 ? -27.02877 -30.38503 17.75404  1.000 31.08938 ? 105 ARG A CB   1 
ATOM   1611 C CG   . ARG A 1 105 ? -27.09335 -29.23549 16.80472  1.000 22.11223 ? 105 ARG A CG   1 
ATOM   1612 C CD   . ARG A 1 105 ? -28.22690 -29.36380 15.83424  1.000 28.89512 ? 105 ARG A CD   1 
ATOM   1613 N NE   . ARG A 1 105 ? -28.33461 -28.13441 15.06696  1.000 32.36657 ? 105 ARG A NE   1 
ATOM   1614 C CZ   . ARG A 1 105 ? -27.70136 -27.93520 13.92631  1.000 22.96570 ? 105 ARG A CZ   1 
ATOM   1615 N NH1  . ARG A 1 105 ? -26.90446 -28.85526 13.43402  1.000 24.97743 ? 105 ARG A NH1  1 
ATOM   1616 N NH2  . ARG A 1 105 ? -27.86106 -26.77793 13.28396  1.000 24.92937 ? 105 ARG A NH2  1 
ATOM   1617 H H    . ARG A 1 105 ? -26.29405 -32.04850 19.47827  1.000 28.10527 ? 105 ARG A H    1 
ATOM   1618 H HA   . ARG A 1 105 ? -24.98870 -30.46639 17.74270  1.000 32.80650 ? 105 ARG A HA   1 
ATOM   1619 H HB2  . ARG A 1 105 ? -27.22095 -31.19487 17.25647  1.000 37.30726 ? 105 ARG A HB2  1 
ATOM   1620 H HB3  . ARG A 1 105 ? -27.70412 -30.24698 18.43588  1.000 37.30726 ? 105 ARG A HB3  1 
ATOM   1621 H HG2  . ARG A 1 105 ? -27.21718 -28.41490 17.30618  1.000 26.53468 ? 105 ARG A HG2  1 
ATOM   1622 H HG3  . ARG A 1 105 ? -26.26620 -29.19352 16.29804  1.000 26.53468 ? 105 ARG A HG3  1 
ATOM   1623 H HD2  . ARG A 1 105 ? -28.06010 -30.10129 15.22585  1.000 34.67415 ? 105 ARG A HD2  1 
ATOM   1624 H HD3  . ARG A 1 105 ? -29.05795 -29.51075 16.31286  1.000 34.67415 ? 105 ARG A HD3  1 
ATOM   1625 H HE   . ARG A 1 105 ? -28.83522 -27.50599 15.37217  1.000 38.83989 ? 105 ARG A HE   1 
ATOM   1626 H HH11 . ARG A 1 105 ? -26.79002 -29.59543 13.85661  1.000 29.97291 ? 105 ARG A HH11 1 
ATOM   1627 H HH12 . ARG A 1 105 ? -26.49630 -28.71648 12.69025  1.000 29.97291 ? 105 ARG A HH12 1 
ATOM   1628 H HH21 . ARG A 1 105 ? -28.37266 -26.17054 13.61416  1.000 29.91524 ? 105 ARG A HH21 1 
ATOM   1629 H HH22 . ARG A 1 105 ? -27.45291 -26.63915 12.54019  1.000 29.91524 ? 105 ARG A HH22 1 
ATOM   1630 N N    . ILE A 1 106 ? -24.26359 -28.82685 19.41497  1.000 21.69120 ? 106 ILE A N    1 
ATOM   1631 C CA   . ILE A 1 106 ? -23.97076 -27.78020 20.37272  1.000 22.66457 ? 106 ILE A CA   1 
ATOM   1632 C C    . ILE A 1 106 ? -24.72067 -26.49860 20.04125  1.000 20.96916 ? 106 ILE A C    1 
ATOM   1633 O O    . ILE A 1 106 ? -25.21842 -26.31030 18.92619  1.000 25.63076 ? 106 ILE A O    1 
ATOM   1634 C CB   . ILE A 1 106 ? -22.46402 -27.49606 20.46943  1.000 27.22473 ? 106 ILE A CB   1 
ATOM   1635 C CG1  . ILE A 1 106 ? -21.89290 -27.05779 19.13790  1.000 24.57753 ? 106 ILE A CG1  1 
ATOM   1636 C CG2  . ILE A 1 106 ? -21.74734 -28.65691 21.14497  1.000 39.71744 ? 106 ILE A CG2  1 
ATOM   1637 C CD1  . ILE A 1 106 ? -20.61062 -26.23889 19.34086  1.000 34.11417 ? 106 ILE A CD1  1 
ATOM   1638 H H    . ILE A 1 106 ? -23.63426 -29.00100 18.85509  1.000 26.02943 ? 106 ILE A H    1 
ATOM   1639 H HA   . ILE A 1 106 ? -24.29082 -28.09599 21.23241  1.000 27.19748 ? 106 ILE A HA   1 
ATOM   1640 H HB   . ILE A 1 106 ? -22.31384 -26.73230 21.04795  1.000 32.66968 ? 106 ILE A HB   1 
ATOM   1641 H HG12 . ILE A 1 106 ? -21.68009 -27.83929 18.60449  1.000 29.49304 ? 106 ILE A HG12 1 
ATOM   1642 H HG13 . ILE A 1 106 ? -22.54218 -26.50602 18.67401  1.000 29.49304 ? 106 ILE A HG13 1 
ATOM   1643 H HG21 . ILE A 1 106 ? -20.80253 -28.44820 21.21243  1.000 47.66093 ? 106 ILE A HG21 1 
ATOM   1644 H HG22 . ILE A 1 106 ? -22.12155 -28.78675 22.03075  1.000 47.66093 ? 106 ILE A HG22 1 
ATOM   1645 H HG23 . ILE A 1 106 ? -21.87151 -29.45868 20.61243  1.000 47.66093 ? 106 ILE A HG23 1 
ATOM   1646 H HD11 . ILE A 1 106 ? -20.27154 -25.96309 18.47515  1.000 40.93701 ? 106 ILE A HD11 1 
ATOM   1647 H HD12 . ILE A 1 106 ? -20.81544 -25.45939 19.88027  1.000 40.93701 ? 106 ILE A HD12 1 
ATOM   1648 H HD13 . ILE A 1 106 ? -19.95235 -26.79065 19.79275  1.000 40.93701 ? 106 ILE A HD13 1 
ATOM   1649 N N    . GLN A 1 107 ? -24.75869 -25.62320 20.97577  1.000 24.14244 ? 107 GLN A N    1 
ATOM   1650 C CA   . GLN A 1 107 ? -25.38671 -24.32166 20.90835  1.000 25.98409 ? 107 GLN A CA   1 
ATOM   1651 C C    . GLN A 1 107 ? -24.33440 -23.28859 20.53836  1.000 25.24472 ? 107 GLN A C    1 
ATOM   1652 O O    . GLN A 1 107 ? -23.15239 -23.44786 20.87268  1.000 22.85279 ? 107 GLN A O    1 
ATOM   1653 C CB   . GLN A 1 107 ? -26.01346 -23.97900 22.26834  1.000 30.18885 ? 107 GLN A CB   1 
ATOM   1654 C CG   . GLN A 1 107 ? -27.16483 -24.91511 22.58636  1.000 36.06859 ? 107 GLN A CG   1 
ATOM   1655 C CD   . GLN A 1 107 ? -28.38369 -24.69955 21.72106  1.000 31.72280 ? 107 GLN A CD   1 
ATOM   1656 O OE1  . GLN A 1 107 ? -28.74248 -23.56463 21.39664  1.000 44.40946 ? 107 GLN A OE1  1 
ATOM   1657 N NE2  . GLN A 1 107 ? -28.97666 -25.79773 21.25818  1.000 45.91442 ? 107 GLN A NE2  1 
ATOM   1658 H H    . GLN A 1 107 ? -24.39686 -25.75239 21.74482  1.000 28.97093 ? 107 GLN A H    1 
ATOM   1659 H HA   . GLN A 1 107 ? -26.09349 -24.29781 20.24612  1.000 31.18090 ? 107 GLN A HA   1 
ATOM   1660 H HB2  . GLN A 1 107 ? -25.34364 -24.06789 22.96453  1.000 36.22662 ? 107 GLN A HB2  1 
ATOM   1661 H HB3  . GLN A 1 107 ? -26.35218 -23.07025 22.24779  1.000 36.22662 ? 107 GLN A HB3  1 
ATOM   1662 H HG2  . GLN A 1 107 ? -26.86905 -25.82979 22.45590  1.000 43.28231 ? 107 GLN A HG2  1 
ATOM   1663 H HG3  . GLN A 1 107 ? -27.43026 -24.78089 23.50935  1.000 43.28231 ? 107 GLN A HG3  1 
ATOM   1664 H HE21 . GLN A 1 107 ? -28.66111 -26.57360 21.45681  1.000 55.09730 ? 107 GLN A HE21 1 
ATOM   1665 H HE22 . GLN A 1 107 ? -29.67453 -25.73298 20.76097  1.000 55.09730 ? 107 GLN A HE22 1 
ATOM   1666 N N    . PRO A 1 108 ? -24.71695 -22.25843 19.78386  1.000 24.98423 ? 108 PRO A N    1 
ATOM   1667 C CA   . PRO A 1 108 ? -23.77973 -21.15852 19.52387  1.000 18.65585 ? 108 PRO A CA   1 
ATOM   1668 C C    . PRO A 1 108 ? -23.20560 -20.65188 20.83539  1.000 21.82581 ? 108 PRO A C    1 
ATOM   1669 O O    . PRO A 1 108 ? -23.89299 -20.61105 21.85617  1.000 22.66115 ? 108 PRO A O    1 
ATOM   1670 C CB   . PRO A 1 108 ? -24.64732 -20.10578 18.81321  1.000 29.33201 ? 108 PRO A CB   1 
ATOM   1671 C CG   . PRO A 1 108 ? -26.03329 -20.36919 19.30856  1.000 29.93879 ? 108 PRO A CG   1 
ATOM   1672 C CD   . PRO A 1 108 ? -26.11212 -21.88532 19.43160  1.000 32.48049 ? 108 PRO A CD   1 
ATOM   1673 H HA   . PRO A 1 108 ? -23.06531 -21.42459 18.92496  1.000 22.38702 ? 108 PRO A HA   1 
ATOM   1674 H HB2  . PRO A 1 108 ? -24.35312 -19.21369 19.05687  1.000 35.19841 ? 108 PRO A HB2  1 
ATOM   1675 H HB3  . PRO A 1 108 ? -24.59089 -20.22314 17.85216  1.000 35.19841 ? 108 PRO A HB3  1 
ATOM   1676 H HG2  . PRO A 1 108 ? -26.16593 -19.94182 20.16978  1.000 35.92655 ? 108 PRO A HG2  1 
ATOM   1677 H HG3  . PRO A 1 108 ? -26.68333 -20.03731 18.66954  1.000 35.92655 ? 108 PRO A HG3  1 
ATOM   1678 H HD2  . PRO A 1 108 ? -26.72917 -22.14525 20.13322  1.000 38.97659 ? 108 PRO A HD2  1 
ATOM   1679 H HD3  . PRO A 1 108 ? -26.37751 -22.28802 18.59026  1.000 38.97659 ? 108 PRO A HD3  1 
ATOM   1680 N N    . GLY A 1 109 ? -21.92988 -20.29385 20.81506  1.000 19.95354 ? 109 GLY A N    1 
ATOM   1681 C CA   . GLY A 1 109 ? -21.24466 -19.84704 22.00858  1.000 19.84843 ? 109 GLY A CA   1 
ATOM   1682 C C    . GLY A 1 109 ? -20.55207 -20.93497 22.79415  1.000 27.72332 ? 109 GLY A C    1 
ATOM   1683 O O    . GLY A 1 109 ? -19.69862 -20.60981 23.62965  1.000 27.74899 ? 109 GLY A O    1 
ATOM   1684 H H    . GLY A 1 109 ? -21.43662 -20.30302 20.11023  1.000 23.94424 ? 109 GLY A H    1 
ATOM   1685 H HA2  . GLY A 1 109 ? -20.57409 -19.19335 21.75521  1.000 23.81811 ? 109 GLY A HA2  1 
ATOM   1686 H HA3  . GLY A 1 109 ? -21.89020 -19.42491 22.59661  1.000 23.81811 ? 109 GLY A HA3  1 
ATOM   1687 N N    . GLN A 1 110 ? -20.89698 -22.20312 22.58425  1.000 21.59757 ? 110 GLN A N    1 
ATOM   1688 C CA   . GLN A 1 110 ? -20.18534 -23.29595 23.23182  1.000 19.40350 ? 110 GLN A CA   1 
ATOM   1689 C C    . GLN A 1 110 ? -18.85090 -23.54145 22.53014  1.000 22.56072 ? 110 GLN A C    1 
ATOM   1690 O O    . GLN A 1 110 ? -18.60088 -23.07657 21.42352  1.000 20.77262 ? 110 GLN A O    1 
ATOM   1691 C CB   . GLN A 1 110 ? -21.02034 -24.57264 23.27474  1.000 21.76756 ? 110 GLN A CB   1 
ATOM   1692 C CG   . GLN A 1 110 ? -22.21373 -24.49817 24.21137  1.000 32.67579 ? 110 GLN A CG   1 
ATOM   1693 C CD   . GLN A 1 110 ? -21.85764 -23.96674 25.59682  1.000 43.92008 ? 110 GLN A CD   1 
ATOM   1694 O OE1  . GLN A 1 110 ? -21.19637 -24.66760 26.38877  1.000 42.06672 ? 110 GLN A OE1  1 
ATOM   1695 N NE2  . GLN A 1 110 ? -22.24963 -22.73045 25.88883  1.000 39.52822 ? 110 GLN A NE2  1 
ATOM   1696 H H    . GLN A 1 110 ? -21.53960 -22.45531 22.07086  1.000 25.91708 ? 110 GLN A H    1 
ATOM   1697 H HA   . GLN A 1 110 ? -20.00686 -23.05638 24.15503  1.000 23.28420 ? 110 GLN A HA   1 
ATOM   1698 H HB2  . GLN A 1 110 ? -21.35588 -24.75536 22.38351  1.000 26.12107 ? 110 GLN A HB2  1 
ATOM   1699 H HB3  . GLN A 1 110 ? -20.45587 -25.30338 23.57349  1.000 26.12107 ? 110 GLN A HB3  1 
ATOM   1700 H HG2  . GLN A 1 110 ? -22.87907 -23.90446 23.82750  1.000 39.21095 ? 110 GLN A HG2  1 
ATOM   1701 H HG3  . GLN A 1 110 ? -22.58606 -25.38753 24.31969  1.000 39.21095 ? 110 GLN A HG3  1 
ATOM   1702 H HE21 . GLN A 1 110 ? -22.68370 -22.26785 25.30847  1.000 47.43387 ? 110 GLN A HE21 1 
ATOM   1703 H HE22 . GLN A 1 110 ? -22.06884 -22.39305 26.65938  1.000 47.43387 ? 110 GLN A HE22 1 
ATOM   1704 N N    . THR A 1 111 ? -17.96160 -24.23118 23.23703  1.000 26.58954 ? 111 THR A N    1 
ATOM   1705 C CA   . THR A 1 111 ? -16.61024 -24.46881 22.75436  1.000 23.48187 ? 111 THR A CA   1 
ATOM   1706 C C    . THR A 1 111 ? -16.39298 -25.96351 22.55552  1.000 21.39651 ? 111 THR A C    1 
ATOM   1707 O O    . THR A 1 111 ? -17.11051 -26.79343 23.11075  1.000 22.05129 ? 111 THR A O    1 
ATOM   1708 C CB   . THR A 1 111 ? -15.59103 -23.91561 23.74306  1.000 22.63875 ? 111 THR A CB   1 
ATOM   1709 O OG1  . THR A 1 111 ? -15.79594 -24.57754 24.99058  1.000 22.06345 ? 111 THR A OG1  1 
ATOM   1710 C CG2  . THR A 1 111 ? -15.78430 -22.42391 23.98891  1.000 23.94562 ? 111 THR A CG2  1 
ATOM   1711 H H    . THR A 1 111 ? -18.12160 -24.57479 24.00876  1.000 31.90745 ? 111 THR A H    1 
ATOM   1712 H HA   . THR A 1 111 ? -16.47728 -24.03218 21.89868  1.000 28.17824 ? 111 THR A HA   1 
ATOM   1713 H HB   . THR A 1 111 ? -14.69879 -24.05268 23.38829  1.000 27.16650 ? 111 THR A HB   1 
ATOM   1714 H HG1  . THR A 1 111 ? -15.16026 -24.40835 25.51291  1.000 26.47614 ? 111 THR A HG1  1 
ATOM   1715 H HG21 . THR A 1 111 ? -15.17179 -22.11885 24.67632  1.000 28.73474 ? 111 THR A HG21 1 
ATOM   1716 H HG22 . THR A 1 111 ? -15.61341 -21.92827 23.17228  1.000 28.73474 ? 111 THR A HG22 1 
ATOM   1717 H HG23 . THR A 1 111 ? -16.69354 -22.24981 24.27770  1.000 28.73474 ? 111 THR A HG23 1 
ATOM   1718 N N    . PHE A 1 112 ? -15.37943 -26.30022 21.75967  1.000 21.66341 ? 112 PHE A N    1 
ATOM   1719 C CA   . PHE A 1 112 ? -15.04224 -27.68880 21.51493  1.000 18.75059 ? 112 PHE A CA   1 
ATOM   1720 C C    . PHE A 1 112 ? -13.61902 -27.73134 20.99440  1.000 16.97414 ? 112 PHE A C    1 
ATOM   1721 O O    . PHE A 1 112 ? -13.06666 -26.72263 20.54522  1.000 20.50706 ? 112 PHE A O    1 
ATOM   1722 C CB   . PHE A 1 112 ? -16.03535 -28.35797 20.50817  1.000 17.21526 ? 112 PHE A CB   1 
ATOM   1723 C CG   . PHE A 1 112 ? -16.20143 -27.65327 19.15354  1.000 16.02796 ? 112 PHE A CG   1 
ATOM   1724 C CD1  . PHE A 1 112 ? -15.39180 -27.97597 18.09263  1.000 18.77225 ? 112 PHE A CD1  1 
ATOM   1725 C CD2  . PHE A 1 112 ? -17.19411 -26.71494 18.96277  1.000 27.66980 ? 112 PHE A CD2  1 
ATOM   1726 C CE1  . PHE A 1 112 ? -15.57684 -27.35132 16.79795  1.000 17.48195 ? 112 PHE A CE1  1 
ATOM   1727 C CE2  . PHE A 1 112 ? -17.36319 -26.08233 17.75210  1.000 22.77603 ? 112 PHE A CE2  1 
ATOM   1728 C CZ   . PHE A 1 112 ? -16.56754 -26.40602 16.65618  1.000 21.54498 ? 112 PHE A CZ   1 
ATOM   1729 H H    . PHE A 1 112 ? -14.87373 -25.73756 21.35119  1.000 25.99610 ? 112 PHE A H    1 
ATOM   1730 H HA   . PHE A 1 112 ? -15.08513 -28.19334 22.34260  1.000 22.50071 ? 112 PHE A HA   1 
ATOM   1731 H HB2  . PHE A 1 112 ? -15.72157 -29.25761 20.32672  1.000 20.65831 ? 112 PHE A HB2  1 
ATOM   1732 H HB3  . PHE A 1 112 ? -16.91147 -28.38992 20.92384  1.000 20.65831 ? 112 PHE A HB3  1 
ATOM   1733 H HD1  . PHE A 1 112 ? -14.71534 -28.60450 18.20648  1.000 22.52670 ? 112 PHE A HD1  1 
ATOM   1734 H HD2  . PHE A 1 112 ? -17.76153 -26.50482 19.66870  1.000 33.20376 ? 112 PHE A HD2  1 
ATOM   1735 H HE1  . PHE A 1 112 ? -15.03640 -27.58444 16.07699  1.000 20.97834 ? 112 PHE A HE1  1 
ATOM   1736 H HE2  . PHE A 1 112 ? -18.01968 -25.42979 17.66427  1.000 27.33124 ? 112 PHE A HE2  1 
ATOM   1737 H HZ   . PHE A 1 112 ? -16.70359 -25.98762 15.83739  1.000 25.85397 ? 112 PHE A HZ   1 
ATOM   1738 N N    . SER A 1 113 ? -13.03609 -28.92892 21.05987  1.000 17.88736 ? 113 SER A N    1 
ATOM   1739 C CA   . SER A 1 113 ? -11.73068 -29.18553 20.48317  1.000 18.79401 ? 113 SER A CA   1 
ATOM   1740 C C    . SER A 1 113 ? -11.89075 -29.72278 19.05879  1.000 16.23194 ? 113 SER A C    1 
ATOM   1741 O O    . SER A 1 113 ? -12.80902 -30.50732 18.75598  1.000 20.22129 ? 113 SER A O    1 
ATOM   1742 C CB   . SER A 1 113 ? -10.94321 -30.15844 21.35185  1.000 18.54335 ? 113 SER A CB   1 
ATOM   1743 O OG   . SER A 1 113 ? -10.79508 -29.65913 22.67021  1.000 20.14592 ? 113 SER A OG   1 
ATOM   1744 H H    . SER A 1 113 ? -13.38768 -29.61544 21.43932  1.000 21.46483 ? 113 SER A H    1 
ATOM   1745 H HA   . SER A 1 113 ? -11.21532 -28.36509 20.43486  1.000 22.55281 ? 113 SER A HA   1 
ATOM   1746 H HB2  . SER A 1 113 ? -11.41755 -31.00384 21.38716  1.000 22.25202 ? 113 SER A HB2  1 
ATOM   1747 H HB3  . SER A 1 113 ? -10.06397 -30.28750 20.96308  1.000 22.25202 ? 113 SER A HB3  1 
ATOM   1748 H HG   . SER A 1 113 ? -10.37165 -28.93378 22.65581  1.000 24.17510 ? 113 SER A HG   1 
ATOM   1749 N N    . VAL A 1 114 ? -10.96877 -29.31351 18.19636  1.000 16.37979 ? 114 VAL A N    1 
ATOM   1750 C CA   . VAL A 1 114 ? -10.89992 -29.76761 16.82311  1.000 17.36453 ? 114 VAL A CA   1 
ATOM   1751 C C    . VAL A 1 114 ? -9.61025  -30.55251 16.70208  1.000 18.54504 ? 114 VAL A C    1 
ATOM   1752 O O    . VAL A 1 114 ? -8.53978  -30.03386 17.02578  1.000 19.55228 ? 114 VAL A O    1 
ATOM   1753 C CB   . VAL A 1 114 ? -10.92850 -28.59601 15.80782  1.000 21.19036 ? 114 VAL A CB   1 
ATOM   1754 C CG1  . VAL A 1 114 ? -10.67860 -29.07992 14.36861  1.000 19.27588 ? 114 VAL A CG1  1 
ATOM   1755 C CG2  . VAL A 1 114 ? -12.22616 -27.82712 15.94384  1.000 21.62558 ? 114 VAL A CG2  1 
ATOM   1756 H H    . VAL A 1 114 ? -10.35029 -28.75014 18.39593  1.000 19.65575 ? 114 VAL A H    1 
ATOM   1757 H HA   . VAL A 1 114 ? -11.65640 -30.34209 16.62649  1.000 20.83744 ? 114 VAL A HA   1 
ATOM   1758 H HB   . VAL A 1 114 ? -10.20105 -27.98655 16.00845  1.000 25.42843 ? 114 VAL A HB   1 
ATOM   1759 H HG11 . VAL A 1 114 ? -10.91795 -28.37173 13.75096  1.000 23.13105 ? 114 VAL A HG11 1 
ATOM   1760 H HG12 . VAL A 1 114 ? -9.73939  -29.30211 14.26880  1.000 23.13105 ? 114 VAL A HG12 1 
ATOM   1761 H HG13 . VAL A 1 114 ? -11.22292 -29.86425 14.19993  1.000 23.13105 ? 114 VAL A HG13 1 
ATOM   1762 H HG21 . VAL A 1 114 ? -12.21454 -27.07573 15.32930  1.000 25.95070 ? 114 VAL A HG21 1 
ATOM   1763 H HG22 . VAL A 1 114 ? -12.96661 -28.41558 15.73021  1.000 25.95070 ? 114 VAL A HG22 1 
ATOM   1764 H HG23 . VAL A 1 114 ? -12.31073 -27.50675 16.85500  1.000 25.95070 ? 114 VAL A HG23 1 
ATOM   1765 N N    . LEU A 1 115 ? -9.70611  -31.78030 16.23729  1.000 16.04885 ? 115 LEU A N    1 
ATOM   1766 C CA   . LEU A 1 115 ? -8.56033  -32.53807 15.72522  1.000 18.21126 ? 115 LEU A CA   1 
ATOM   1767 C C    . LEU A 1 115 ? -8.49497  -32.32409 14.21438  1.000 17.20693 ? 115 LEU A C    1 
ATOM   1768 O O    . LEU A 1 115 ? -9.25822  -32.92823 13.45274  1.000 17.76175 ? 115 LEU A O    1 
ATOM   1769 C CB   . LEU A 1 115 ? -8.67928  -34.01238 16.06927  1.000 20.55933 ? 115 LEU A CB   1 
ATOM   1770 C CG   . LEU A 1 115 ? -7.46748  -34.87021 15.73917  1.000 17.26118 ? 115 LEU A CG   1 
ATOM   1771 C CD1  . LEU A 1 115 ? -6.25909  -34.46075 16.55385  1.000 18.36574 ? 115 LEU A CD1  1 
ATOM   1772 C CD2  . LEU A 1 115 ? -7.79940  -36.33463 15.99615  1.000 23.94176 ? 115 LEU A CD2  1 
ATOM   1773 H H    . LEU A 1 115 ? -10.44375 -32.21987 16.20276  1.000 19.25862 ? 115 LEU A H    1 
ATOM   1774 H HA   . LEU A 1 115 ? -7.74574  -32.19967 16.12872  1.000 21.85351 ? 115 LEU A HA   1 
ATOM   1775 H HB2  . LEU A 1 115 ? -8.83455  -34.08909 17.02417  1.000 24.67120 ? 115 LEU A HB2  1 
ATOM   1776 H HB3  . LEU A 1 115 ? -9.43281  -34.37768 15.57978  1.000 24.67120 ? 115 LEU A HB3  1 
ATOM   1777 H HG   . LEU A 1 115 ? -7.24124  -34.74845 14.80333  1.000 20.71342 ? 115 LEU A HG   1 
ATOM   1778 H HD11 . LEU A 1 115 ? -5.54853  -35.10610 16.41170  1.000 22.03889 ? 115 LEU A HD11 1 
ATOM   1779 H HD12 . LEU A 1 115 ? -5.96869  -33.58034 16.26750  1.000 22.03889 ? 115 LEU A HD12 1 
ATOM   1780 H HD13 . LEU A 1 115 ? -6.50344  -34.43952 17.49178  1.000 22.03889 ? 115 LEU A HD13 1 
ATOM   1781 H HD21 . LEU A 1 115 ? -7.09583  -36.88784 15.62306  1.000 28.73011 ? 115 LEU A HD21 1 
ATOM   1782 H HD22 . LEU A 1 115 ? -7.86362  -36.48028 16.95304  1.000 28.73011 ? 115 LEU A HD22 1 
ATOM   1783 H HD23 . LEU A 1 115 ? -8.64608  -36.54605 15.57172  1.000 28.73011 ? 115 LEU A HD23 1 
ATOM   1784 N N    . ALA A 1 116 ? -7.56148  -31.47907 13.76223  1.000 16.68037 ? 116 ALA A N    1 
ATOM   1785 C CA   . ALA A 1 116 ? -7.35318  -31.22002 12.33846  1.000 19.82902 ? 116 ALA A CA   1 
ATOM   1786 C C    . ALA A 1 116 ? -6.54006  -32.36801 11.74904  1.000 19.48398 ? 116 ALA A C    1 
ATOM   1787 O O    . ALA A 1 116 ? -5.48197  -32.71350 12.28020  1.000 24.61106 ? 116 ALA A O    1 
ATOM   1788 C CB   . ALA A 1 116 ? -6.61116  -29.89931 12.14354  1.000 22.06790 ? 116 ALA A CB   1 
ATOM   1789 H H    . ALA A 1 116 ? -7.02801  -31.03695 14.27069  1.000 20.01644 ? 116 ALA A H    1 
ATOM   1790 H HA   . ALA A 1 116 ? -8.20507  -31.15642 11.87920  1.000 23.79482 ? 116 ALA A HA   1 
ATOM   1791 H HB1  . ALA A 1 116 ? -6.51796  -29.72765 11.19268  1.000 26.48148 ? 116 ALA A HB1  1 
ATOM   1792 H HB2  . ALA A 1 116 ? -7.12088  -29.18597 12.55980  1.000 26.48148 ? 116 ALA A HB2  1 
ATOM   1793 H HB3  . ALA A 1 116 ? -5.73626  -29.96487 12.55481  1.000 26.48148 ? 116 ALA A HB3  1 
ATOM   1794 N N    . CYS A 1 117 ? -7.04121  -32.95775 10.67050  1.000 18.53794 ? 117 CYS A N    1 
ATOM   1795 C CA   . CYS A 1 117 ? -6.46905  -34.14792 10.06297  1.000 21.29603 ? 117 CYS A CA   1 
ATOM   1796 C C    . CYS A 1 117 ? -6.32866  -33.95788 8.55613   1.000 22.13445 ? 117 CYS A C    1 
ATOM   1797 O O    . CYS A 1 117 ? -7.09903  -33.22911 7.94431   1.000 23.50086 ? 117 CYS A O    1 
ATOM   1798 C CB   . CYS A 1 117 ? -7.37716  -35.34577 10.26591  1.000 25.37867 ? 117 CYS A CB   1 
ATOM   1799 S SG   . CYS A 1 117 ? -7.54235  -35.84892 11.92754  1.000 25.84117 ? 117 CYS A SG   1 
ATOM   1800 H H    . CYS A 1 117 ? -7.73929  -32.67405 10.25643  1.000 22.24553 ? 117 CYS A H    1 
ATOM   1801 H HA   . CYS A 1 117 ? -5.59506  -34.30446 10.45618  1.000 25.55524 ? 117 CYS A HA   1 
ATOM   1802 H HB2  . CYS A 1 117 ? -8.26223  -35.12127 9.93774   1.000 30.45440 ? 117 CYS A HB2  1 
ATOM   1803 H HB3  . CYS A 1 117 ? -7.01839  -36.09517 9.76657   1.000 30.45440 ? 117 CYS A HB3  1 
ATOM   1804 H HG   . CYS A 1 117 ? -8.35667  -36.72761 11.98971  1.000 31.00940 ? 117 CYS A HG   1 
ATOM   1805 N N    . TYR A 1 118 ? -5.37788  -34.67975 7.95003   1.000 28.07951 ? 118 TYR A N    1 
ATOM   1806 C CA   . TYR A 1 118 ? -5.23033  -34.71572 6.48205   1.000 29.49596 ? 118 TYR A CA   1 
ATOM   1807 C C    . TYR A 1 118 ? -4.98304  -36.16129 6.08825   1.000 30.89647 ? 118 TYR A C    1 
ATOM   1808 O O    . TYR A 1 118 ? -4.17072  -36.84303 6.71912   1.000 26.37931 ? 118 TYR A O    1 
ATOM   1809 C CB   . TYR A 1 118 ? -4.07987  -33.82052 6.01301   1.000 21.92512 ? 118 TYR A CB   1 
ATOM   1810 C CG   . TYR A 1 118 ? -4.41314  -32.40102 6.39577   1.000 36.73294 ? 118 TYR A CG   1 
ATOM   1811 C CD1  . TYR A 1 118 ? -4.06096  -31.93752 7.66218   1.000 34.29992 ? 118 TYR A CD1  1 
ATOM   1812 C CD2  . TYR A 1 118 ? -5.13351  -31.57108 5.56403   1.000 30.60167 ? 118 TYR A CD2  1 
ATOM   1813 C CE1  . TYR A 1 118 ? -4.38912  -30.66204 8.07585   1.000 29.68800 ? 118 TYR A CE1  1 
ATOM   1814 C CE2  . TYR A 1 118 ? -5.45967  -30.28058 5.94671   1.000 32.11788 ? 118 TYR A CE2  1 
ATOM   1815 C CZ   . TYR A 1 118 ? -5.09048  -29.82907 7.22512   1.000 32.30098 ? 118 TYR A CZ   1 
ATOM   1816 O OH   . TYR A 1 118 ? -5.41864  -28.56359 7.65178   1.000 32.14458 ? 118 TYR A OH   1 
ATOM   1817 H H    . TYR A 1 118 ? -4.79964  -35.16054 8.36793   1.000 33.69542 ? 118 TYR A H    1 
ATOM   1818 H HA   . TYR A 1 118 ? -6.03743  -34.39810 6.04797   1.000 35.39515 ? 118 TYR A HA   1 
ATOM   1819 H HB2  . TYR A 1 118 ? -3.25282  -34.08313 6.44614   1.000 26.31014 ? 118 TYR A HB2  1 
ATOM   1820 H HB3  . TYR A 1 118 ? -3.98349  -33.87785 5.04901   1.000 26.31014 ? 118 TYR A HB3  1 
ATOM   1821 H HD1  . TYR A 1 118 ? -3.59471  -32.49850 8.23900   1.000 41.15990 ? 118 TYR A HD1  1 
ATOM   1822 H HD2  . TYR A 1 118 ? -5.40596  -31.88278 4.73074   1.000 36.72201 ? 118 TYR A HD2  1 
ATOM   1823 H HE1  . TYR A 1 118 ? -4.13965  -30.36536 8.92112   1.000 35.62560 ? 118 TYR A HE1  1 
ATOM   1824 H HE2  . TYR A 1 118 ? -5.91791  -29.71858 5.36489   1.000 38.54145 ? 118 TYR A HE2  1 
ATOM   1825 H HH   . TYR A 1 118 ? -5.47282  -28.04423 6.99408   1.000 38.57350 ? 118 TYR A HH   1 
ATOM   1826 N N    . ASN A 1 119 ? -5.70829  -36.65024 5.07769   1.000 33.33240 ? 119 ASN A N    1 
ATOM   1827 C CA   . ASN A 1 119 ? -5.51804  -38.02682 4.63491   1.000 32.05711 ? 119 ASN A CA   1 
ATOM   1828 C C    . ASN A 1 119 ? -5.75065  -39.01970 5.77122   1.000 36.19524 ? 119 ASN A C    1 
ATOM   1829 O O    . ASN A 1 119 ? -5.13881  -40.09024 5.81677   1.000 36.52464 ? 119 ASN A O    1 
ATOM   1830 C CB   . ASN A 1 119 ? -4.11469  -38.20534 4.04330   1.000 33.79851 ? 119 ASN A CB   1 
ATOM   1831 C CG   . ASN A 1 119 ? -4.02024  -37.70816 2.61323   1.000 44.79534 ? 119 ASN A CG   1 
ATOM   1832 O OD1  . ASN A 1 119 ? -3.10599  -36.95045 2.26558   1.000 49.46349 ? 119 ASN A OD1  1 
ATOM   1833 N ND2  . ASN A 1 119 ? -4.95454  -38.13530 1.76628   1.000 50.99676 ? 119 ASN A ND2  1 
ATOM   1834 H H    . ASN A 1 119 ? -6.30549  -36.20845 4.64275   1.000 39.99888 ? 119 ASN A H    1 
ATOM   1835 H HA   . ASN A 1 119 ? -6.16964  -38.22791 3.94556   1.000 38.46853 ? 119 ASN A HA   1 
ATOM   1836 H HB2  . ASN A 1 119 ? -3.47926  -37.70563 4.57861   1.000 40.55821 ? 119 ASN A HB2  1 
ATOM   1837 H HB3  . ASN A 1 119 ? -3.88625  -39.14878 4.05087   1.000 40.55821 ? 119 ASN A HB3  1 
ATOM   1838 H HD21 . ASN A 1 119 ? -5.57241  -38.66698 2.04040   1.000 61.19611 ? 119 ASN A HD21 1 
ATOM   1839 H HD22 . ASN A 1 119 ? -4.94056  -37.87933 0.94570   1.000 61.19611 ? 119 ASN A HD22 1 
ATOM   1840 N N    . GLY A 1 120 ? -6.64824  -38.68399 6.69311   1.000 25.21391 ? 120 GLY A N    1 
ATOM   1841 C CA   . GLY A 1 120 ? -6.95491  -39.57789 7.76845   1.000 27.31006 ? 120 GLY A CA   1 
ATOM   1842 C C    . GLY A 1 120 ? -5.96028  -39.62180 8.90477   1.000 30.61852 ? 120 GLY A C    1 
ATOM   1843 O O    . GLY A 1 120 ? -6.14796  -40.43852 9.83020   1.000 27.54777 ? 120 GLY A O    1 
ATOM   1844 H H    . GLY A 1 120 ? -7.08384  -37.94334 6.70641   1.000 30.25669 ? 120 GLY A H    1 
ATOM   1845 H HA2  . GLY A 1 120 ? -7.81225  -39.32181 8.14330   1.000 32.77207 ? 120 GLY A HA2  1 
ATOM   1846 H HA3  . GLY A 1 120 ? -7.02407  -40.47573 7.40787   1.000 32.77207 ? 120 GLY A HA3  1 
ATOM   1847 N N    . SER A 1 121 ? -4.91094  -38.77194 8.86367   1.000 29.54365 ? 121 SER A N    1 
ATOM   1848 C CA   . SER A 1 121 ? -3.86139  -38.65173 9.87811   1.000 27.81360 ? 121 SER A CA   1 
ATOM   1849 C C    . SER A 1 121 ? -3.93071  -37.32725 10.62990  1.000 27.35611 ? 121 SER A C    1 
ATOM   1850 O O    . SER A 1 121 ? -3.94036  -36.24288 10.01857  1.000 26.82606 ? 121 SER A O    1 
ATOM   1851 C CB   . SER A 1 121 ? -2.46406  -38.79824 9.26551   1.000 30.02889 ? 121 SER A CB   1 
ATOM   1852 O OG   . SER A 1 121 ? -2.28984  -40.08075 8.69478   1.000 35.12476 ? 121 SER A OG   1 
ATOM   1853 H H    . SER A 1 121 ? -4.78415  -38.22344 8.21405   1.000 35.45238 ? 121 SER A H    1 
ATOM   1854 H HA   . SER A 1 121 ? -4.00705  -39.36824 10.51562  1.000 33.37632 ? 121 SER A HA   1 
ATOM   1855 H HB2  . SER A 1 121 ? -2.35235  -38.12772 8.57297   1.000 36.03467 ? 121 SER A HB2  1 
ATOM   1856 H HB3  . SER A 1 121 ? -1.80041  -38.67014 9.96183   1.000 36.03467 ? 121 SER A HB3  1 
ATOM   1857 H HG   . SER A 1 121 ? -1.99962  -40.61588 9.27456   1.000 42.14971 ? 121 SER A HG   1 
ATOM   1858 N N    . PRO A 1 122 ? -3.88611  -37.41303 11.95387  1.000 27.05854 ? 122 PRO A N    1 
ATOM   1859 C CA   . PRO A 1 122 ? -3.99236  -36.21963 12.79757  1.000 24.61538 ? 122 PRO A CA   1 
ATOM   1860 C C    . PRO A 1 122 ? -2.79305  -35.28859 12.64856  1.000 30.02513 ? 122 PRO A C    1 
ATOM   1861 O O    . PRO A 1 122 ? -1.63872  -35.71469 12.68871  1.000 36.39660 ? 122 PRO A O    1 
ATOM   1862 C CB   . PRO A 1 122 ? -4.06237  -36.83255 14.19316  1.000 31.89479 ? 122 PRO A CB   1 
ATOM   1863 C CG   . PRO A 1 122 ? -4.89230  -38.09710 14.01309  1.000 28.51798 ? 122 PRO A CG   1 
ATOM   1864 C CD   . PRO A 1 122 ? -4.35640  -38.62585 12.67895  1.000 35.55685 ? 122 PRO A CD   1 
ATOM   1865 H HA   . PRO A 1 122 ? -4.79669  -35.71814 12.58959  1.000 29.53845 ? 122 PRO A HA   1 
ATOM   1866 H HB2  . PRO A 1 122 ? -3.16931  -37.04303 14.50835  1.000 38.27375 ? 122 PRO A HB2  1 
ATOM   1867 H HB3  . PRO A 1 122 ? -4.49407  -36.21627 14.80539  1.000 38.27375 ? 122 PRO A HB3  1 
ATOM   1868 H HG2  . PRO A 1 122 ? -4.73206  -38.72142 14.73776  1.000 34.22158 ? 122 PRO A HG2  1 
ATOM   1869 H HG3  . PRO A 1 122 ? -5.83745  -37.88482 13.96089  1.000 34.22158 ? 122 PRO A HG3  1 
ATOM   1870 H HD2  . PRO A 1 122 ? -3.61997  -39.24036 12.82783  1.000 42.66822 ? 122 PRO A HD2  1 
ATOM   1871 H HD3  . PRO A 1 122 ? -5.06088  -39.06810 12.17943  1.000 42.66822 ? 122 PRO A HD3  1 
ATOM   1872 N N    . SER A 1 123 ? -3.06304  -33.98872 12.52727  1.000 25.62674 ? 123 SER A N    1 
ATOM   1873 C CA   . SER A 1 123 ? -2.01481  -32.97483 12.42526  1.000 29.47083 ? 123 SER A CA   1 
ATOM   1874 C C    . SER A 1 123 ? -1.88394  -32.11250 13.68784  1.000 25.89011 ? 123 SER A C    1 
ATOM   1875 O O    . SER A 1 123 ? -0.76034  -31.79085 14.09244  1.000 26.26559 ? 123 SER A O    1 
ATOM   1876 C CB   . SER A 1 123 ? -2.31704  -32.13329 11.17068  1.000 23.51143 ? 123 SER A CB   1 
ATOM   1877 O OG   . SER A 1 123 ? -3.10035  -31.00346 11.44214  1.000 43.94291 ? 123 SER A OG   1 
ATOM   1878 H H    . SER A 1 123 ? -3.85929  -33.66434 12.50119  1.000 30.75209 ? 123 SER A H    1 
ATOM   1879 H HA   . SER A 1 123 ? -1.13845  -33.37606 12.31333  1.000 35.36499 ? 123 SER A HA   1 
ATOM   1880 H HB2  . SER A 1 123 ? -1.47563  -31.83892 10.78881  1.000 28.21372 ? 123 SER A HB2  1 
ATOM   1881 H HB3  . SER A 1 123 ? -2.79233  -32.69061 10.53423  1.000 28.21372 ? 123 SER A HB3  1 
ATOM   1882 H HG   . SER A 1 123 ? -3.24122  -30.57430 10.73366  1.000 52.73150 ? 123 SER A HG   1 
ATOM   1883 N N    . GLY A 1 124 ? -2.98945  -31.77679 14.35566  1.000 19.17392 ? 124 GLY A N    1 
ATOM   1884 C CA   . GLY A 1 124 ? -2.94959  -30.83644 15.46725  1.000 16.47242 ? 124 GLY A CA   1 
ATOM   1885 C C    . GLY A 1 124 ? -4.30089  -30.76694 16.14982  1.000 20.63341 ? 124 GLY A C    1 
ATOM   1886 O O    . GLY A 1 124 ? -5.32336  -31.18041 15.59720  1.000 20.73575 ? 124 GLY A O    1 
ATOM   1887 H H    . GLY A 1 124 ? -3.77514  -32.08231 14.18219  1.000 23.00870 ? 124 GLY A H    1 
ATOM   1888 H HA2  . GLY A 1 124 ? -2.28559  -31.12032 16.11531  1.000 19.76690 ? 124 GLY A HA2  1 
ATOM   1889 H HA3  . GLY A 1 124 ? -2.71618  -29.95306 15.14288  1.000 19.76690 ? 124 GLY A HA3  1 
ATOM   1890 N N    . VAL A 1 125 ? -4.30175  -30.21168 17.34316  1.000 16.63000 ? 125 VAL A N    1 
ATOM   1891 C CA   . VAL A 1 125 ? -5.52515  -30.05113 18.11883  1.000 15.31015 ? 125 VAL A CA   1 
ATOM   1892 C C    . VAL A 1 125 ? -5.57748  -28.63251 18.67169  1.000 19.93046 ? 125 VAL A C    1 
ATOM   1893 O O    . VAL A 1 125 ? -4.54607  -28.03890 19.01742  1.000 19.62416 ? 125 VAL A O    1 
ATOM   1894 C CB   . VAL A 1 125 ? -5.61566  -31.15087 19.19912  1.000 20.01047 ? 125 VAL A CB   1 
ATOM   1895 C CG1  . VAL A 1 125 ? -4.54318  -30.96366 20.24961  1.000 23.04930 ? 125 VAL A CG1  1 
ATOM   1896 C CG2  . VAL A 1 125 ? -7.00184  -31.21037 19.84559  1.000 24.06525 ? 125 VAL A CG2  1 
ATOM   1897 H H    . VAL A 1 125 ? -3.59813  -29.91336 17.73659  1.000 19.95600 ? 125 VAL A H    1 
ATOM   1898 H HA   . VAL A 1 125 ? -6.31289  -30.13341 17.55850  1.000 18.37218 ? 125 VAL A HA   1 
ATOM   1899 H HB   . VAL A 1 125 ? -5.46883  -32.00348 18.76065  1.000 24.01257 ? 125 VAL A HB   1 
ATOM   1900 H HG11 . VAL A 1 125 ? -4.47672  -31.77194 20.78014  1.000 27.65916 ? 125 VAL A HG11 1 
ATOM   1901 H HG12 . VAL A 1 125 ? -3.69716  -30.78672 19.80902  1.000 27.65916 ? 125 VAL A HG12 1 
ATOM   1902 H HG13 . VAL A 1 125 ? -4.78398  -30.21420 20.81599  1.000 27.65916 ? 125 VAL A HG13 1 
ATOM   1903 H HG21 . VAL A 1 125 ? -7.04343  -31.98177 20.43310  1.000 28.87830 ? 125 VAL A HG21 1 
ATOM   1904 H HG22 . VAL A 1 125 ? -7.14767  -30.39880 20.35504  1.000 28.87830 ? 125 VAL A HG22 1 
ATOM   1905 H HG23 . VAL A 1 125 ? -7.67153  -31.28947 19.14931  1.000 28.87830 ? 125 VAL A HG23 1 
ATOM   1906 N N    . TYR A 1 126 ? -6.77493  -28.04143 18.61163  1.000 17.32995 ? 126 TYR A N    1 
ATOM   1907 C CA   . TYR A 1 126 ? -6.96818  -26.71292 19.16038  1.000 22.13331 ? 126 TYR A CA   1 
ATOM   1908 C C    . TYR A 1 126 ? -8.40750  -26.51033 19.59900  1.000 23.45903 ? 126 TYR A C    1 
ATOM   1909 O O    . TYR A 1 126 ? -9.31778  -27.23281 19.20123  1.000 18.49122 ? 126 TYR A O    1 
ATOM   1910 C CB   . TYR A 1 126 ? -6.58867  -25.63699 18.13818  1.000 19.82399 ? 126 TYR A CB   1 
ATOM   1911 C CG   . TYR A 1 126 ? -7.32113  -25.74577 16.83785  1.000 20.15165 ? 126 TYR A CG   1 
ATOM   1912 C CD1  . TYR A 1 126 ? -6.85514  -26.52476 15.80153  1.000 20.26264 ? 126 TYR A CD1  1 
ATOM   1913 C CD2  . TYR A 1 126 ? -8.48763  -25.03958 16.65787  1.000 24.75257 ? 126 TYR A CD2  1 
ATOM   1914 C CE1  . TYR A 1 126 ? -7.55267  -26.58357 14.59825  1.000 19.74923 ? 126 TYR A CE1  1 
ATOM   1915 C CE2  . TYR A 1 126 ? -9.18316  -25.11343 15.51258  1.000 24.51187 ? 126 TYR A CE2  1 
ATOM   1916 C CZ   . TYR A 1 126 ? -8.70721  -25.85842 14.48329  1.000 19.04973 ? 126 TYR A CZ   1 
ATOM   1917 O OH   . TYR A 1 126 ? -9.45878  -25.88631 13.33201  1.000 24.79477 ? 126 TYR A OH   1 
ATOM   1918 H H    . TYR A 1 126 ? -7.47852  -28.39177 18.26116  1.000 20.79594 ? 126 TYR A H    1 
ATOM   1919 H HA   . TYR A 1 126 ? -6.41052  -26.63096 19.95063  1.000 26.55997 ? 126 TYR A HA   1 
ATOM   1920 H HB2  . TYR A 1 126 ? -6.78650  -24.76638 18.51564  1.000 23.78878 ? 126 TYR A HB2  1 
ATOM   1921 H HB3  . TYR A 1 126 ? -5.63955  -25.70911 17.94847  1.000 23.78878 ? 126 TYR A HB3  1 
ATOM   1922 H HD1  . TYR A 1 126 ? -6.07179  -27.01420 15.90751  1.000 24.31516 ? 126 TYR A HD1  1 
ATOM   1923 H HD2  . TYR A 1 126 ? -8.80230  -24.49826 17.34510  1.000 29.70309 ? 126 TYR A HD2  1 
ATOM   1924 H HE1  . TYR A 1 126 ? -7.24101  -27.10089 13.89104  1.000 23.69907 ? 126 TYR A HE1  1 
ATOM   1925 H HE2  . TYR A 1 126 ? -9.98850  -24.65702 15.42558  1.000 29.41424 ? 126 TYR A HE2  1 
ATOM   1926 H HH   . TYR A 1 126 ? -9.05023  -26.30861 12.73189  1.000 29.75372 ? 126 TYR A HH   1 
ATOM   1927 N N    . GLN A 1 127 ? -8.58959  -25.52802 20.47654  1.000 20.66829 ? 127 GLN A N    1 
ATOM   1928 C CA   . GLN A 1 127 ? -9.87606  -25.21342 21.09128  1.000 20.66882 ? 127 GLN A CA   1 
ATOM   1929 C C    . GLN A 1 127 ? -10.51470 -24.06846 20.32876  1.000 28.69295 ? 127 GLN A C    1 
ATOM   1930 O O    . GLN A 1 127 ? -9.82327  -23.14764 19.88657  1.000 34.07778 ? 127 GLN A O    1 
ATOM   1931 C CB   . GLN A 1 127 ? -9.65989  -24.81416 22.55960  1.000 23.40442 ? 127 GLN A CB   1 
ATOM   1932 C CG   . GLN A 1 127 ? -10.89627 -24.68261 23.33025  1.000 29.62492 ? 127 GLN A CG   1 
ATOM   1933 C CD   . GLN A 1 127 ? -11.51835 -26.00835 23.72021  1.000 20.43876 ? 127 GLN A CD   1 
ATOM   1934 O OE1  . GLN A 1 127 ? -11.04035 -27.07270 23.28872  1.000 28.27040 ? 127 GLN A OE1  1 
ATOM   1935 N NE2  . GLN A 1 127 ? -12.59566 -25.96869 24.49585  1.000 24.23563 ? 127 GLN A NE2  1 
ATOM   1936 H H    . GLN A 1 127 ? -7.95709  -25.00868 20.74308  1.000 24.80195 ? 127 GLN A H    1 
ATOM   1937 H HA   . GLN A 1 127 ? -10.47444 -25.97688 21.06260  1.000 24.80258 ? 127 GLN A HA   1 
ATOM   1938 H HB2  . GLN A 1 127 ? -9.11550  -25.49299 22.98937  1.000 28.08531 ? 127 GLN A HB2  1 
ATOM   1939 H HB3  . GLN A 1 127 ? -9.20358  -23.95881 22.58529  1.000 28.08531 ? 127 GLN A HB3  1 
ATOM   1940 H HG2  . GLN A 1 127 ? -10.70495 -24.19496 24.14561  1.000 35.54991 ? 127 GLN A HG2  1 
ATOM   1941 H HG3  . GLN A 1 127 ? -11.54547 -24.19780 22.79732  1.000 35.54991 ? 127 GLN A HG3  1 
ATOM   1942 H HE21 . GLN A 1 127 ? -12.91135 -25.21210 24.75521  1.000 29.08276 ? 127 GLN A HE21 1 
ATOM   1943 H HE22 . GLN A 1 127 ? -12.97716 -26.70014 24.73927  1.000 29.08276 ? 127 GLN A HE22 1 
ATOM   1944 N N    . CYS A 1 128 ? -11.83361 -24.10641 20.16627  1.000 24.59554 ? 128 CYS A N    1 
ATOM   1945 C CA   . CYS A 1 128 ? -12.49320 -23.03648 19.42270  1.000 31.81682 ? 128 CYS A CA   1 
ATOM   1946 C C    . CYS A 1 128 ? -13.94143 -22.93690 19.86025  1.000 27.64344 ? 128 CYS A C    1 
ATOM   1947 O O    . CYS A 1 128 ? -14.44503 -23.77376 20.60855  1.000 23.98743 ? 128 CYS A O    1 
ATOM   1948 C CB   . CYS A 1 128 ? -12.35349 -23.26845 17.93160  1.000 28.16463 ? 128 CYS A CB   1 
ATOM   1949 S SG   . CYS A 1 128 ? -13.51436 -24.43602 17.36447  1.000 37.82045 ? 128 CYS A SG   1 
ATOM   1950 H H    . CYS A 1 128 ? -12.35223 -24.72201 20.46771  1.000 29.51465 ? 128 CYS A H    1 
ATOM   1951 H HA   . CYS A 1 128 ? -12.08495 -22.18228 19.63437  1.000 38.18018 ? 128 CYS A HA   1 
ATOM   1952 H HB2  . CYS A 1 128 ? -12.50299 -22.43328 17.46106  1.000 33.79755 ? 128 CYS A HB2  1 
ATOM   1953 H HB3  . CYS A 1 128 ? -11.46316 -23.60162 17.74071  1.000 33.79755 ? 128 CYS A HB3  1 
ATOM   1954 H HG   . CYS A 1 128 ? -13.43487 -24.51622 16.16945  1.000 45.38454 ? 128 CYS A HG   1 
ATOM   1955 N N    . ALA A 1 129 ? -14.57817 -21.84016 19.46170  1.000 24.75601 ? 129 ALA A N    1 
ATOM   1956 C CA   . ALA A 1 129 ? -15.96448 -21.60548 19.81935  1.000 22.47645 ? 129 ALA A CA   1 
ATOM   1957 C C    . ALA A 1 129 ? -16.80696 -21.69638 18.55500  1.000 16.07235 ? 129 ALA A C    1 
ATOM   1958 O O    . ALA A 1 129 ? -16.35989 -21.31036 17.48540  1.000 21.88601 ? 129 ALA A O    1 
ATOM   1959 C CB   . ALA A 1 129 ? -16.16680 -20.23504 20.46613  1.000 23.19832 ? 129 ALA A CB   1 
ATOM   1960 H H    . ALA A 1 129 ? -14.22449 -21.21958 18.98321  1.000 29.70721 ? 129 ALA A H    1 
ATOM   1961 H HA   . ALA A 1 129 ? -16.25518 -22.27111 20.46184  1.000 26.97174 ? 129 ALA A HA   1 
ATOM   1962 H HB1  . ALA A 1 129 ? -17.06797 -20.18198 20.81884  1.000 27.83799 ? 129 ALA A HB1  1 
ATOM   1963 H HB2  . ALA A 1 129 ? -15.52314 -20.12697 21.18442  1.000 27.83799 ? 129 ALA A HB2  1 
ATOM   1964 H HB3  . ALA A 1 129 ? -16.03211 -19.54652 19.79560  1.000 27.83799 ? 129 ALA A HB3  1 
ATOM   1965 N N    . MET A 1 130 ? -18.02562 -22.19344 18.70626  1.000 18.09812 ? 130 MET A N    1 
ATOM   1966 C CA   . MET A 1 130 ? -19.04942 -22.00163 17.69402  1.000 21.16862 ? 130 MET A CA   1 
ATOM   1967 C C    . MET A 1 130 ? -19.52762 -20.54809 17.82075  1.000 27.29288 ? 130 MET A C    1 
ATOM   1968 O O    . MET A 1 130 ? -20.10328 -20.16918 18.85478  1.000 21.38464 ? 130 MET A O    1 
ATOM   1969 C CB   . MET A 1 130 ? -20.20273 -22.96670 17.93802  1.000 19.47192 ? 130 MET A CB   1 
ATOM   1970 C CG   . MET A 1 130 ? -21.41541 -22.86019 17.03003  1.000 27.06833 ? 130 MET A CG   1 
ATOM   1971 S SD   . MET A 1 130 ? -20.97474 -23.14424 15.30344  1.000 28.15189 ? 130 MET A SD   1 
ATOM   1972 C CE   . MET A 1 130 ? -20.55518 -24.84335 15.24005  1.000 24.52228 ? 130 MET A CE   1 
ATOM   1973 H H    . MET A 1 130 ? -18.28550 -22.64907 19.38889  1.000 21.71774 ? 130 MET A H    1 
ATOM   1974 H HA   . MET A 1 130 ? -18.70496 -22.18081 16.80503  1.000 25.40235 ? 130 MET A HA   1 
ATOM   1975 H HB2  . MET A 1 130 ? -19.86048 -23.86920 17.84148  1.000 23.36630 ? 130 MET A HB2  1 
ATOM   1976 H HB3  . MET A 1 130 ? -20.51983 -22.82732 18.84483  1.000 23.36630 ? 130 MET A HB3  1 
ATOM   1977 H HG2  . MET A 1 130 ? -22.07183 -23.52586 17.29174  1.000 32.48200 ? 130 MET A HG2  1 
ATOM   1978 H HG3  . MET A 1 130 ? -21.79626 -21.97120 17.10602  1.000 32.48200 ? 130 MET A HG3  1 
ATOM   1979 H HE1  . MET A 1 130 ? -20.30289 -25.07292 14.33173  1.000 29.42673 ? 130 MET A HE1  1 
ATOM   1980 H HE2  . MET A 1 130 ? -19.81163 -25.00696 15.84069  1.000 29.42673 ? 130 MET A HE2  1 
ATOM   1981 H HE3  . MET A 1 130 ? -21.32338 -25.36861 15.51388  1.000 29.42673 ? 130 MET A HE3  1 
ATOM   1982 N N    . ARG A 1 131 ? -19.28391 -19.72726 16.79234  1.000 18.10051 ? 131 ARG A N    1 
ATOM   1983 C CA   . ARG A 1 131 ? -19.65204 -18.32958 16.84007  1.000 19.40114 ? 131 ARG A CA   1 
ATOM   1984 C C    . ARG A 1 131 ? -21.17017 -18.17881 16.87163  1.000 20.82921 ? 131 ARG A C    1 
ATOM   1985 O O    . ARG A 1 131 ? -21.89831 -19.06612 16.43882  1.000 18.95141 ? 131 ARG A O    1 
ATOM   1986 C CB   . ARG A 1 131 ? -19.12823 -17.54542 15.63274  1.000 23.62758 ? 131 ARG A CB   1 
ATOM   1987 C CG   . ARG A 1 131 ? -17.63709 -17.60107 15.36523  1.000 20.41195 ? 131 ARG A CG   1 
ATOM   1988 C CD   . ARG A 1 131 ? -16.78893 -17.04909 16.49487  1.000 25.30786 ? 131 ARG A CD   1 
ATOM   1989 N NE   . ARG A 1 131 ? -17.28613 -15.81586 17.10546  1.000 23.87963 ? 131 ARG A NE   1 
ATOM   1990 C CZ   . ARG A 1 131 ? -16.95785 -15.45136 18.33180  1.000 30.20277 ? 131 ARG A CZ   1 
ATOM   1991 N NH1  . ARG A 1 131 ? -16.15652 -16.19917 19.06662  1.000 23.22070 ? 131 ARG A NH1  1 
ATOM   1992 N NH2  . ARG A 1 131 ? -17.43294 -14.30604 18.82634  1.000 26.76131 ? 131 ARG A NH2  1 
ATOM   1993 H H    . ARG A 1 131 ? -18.90346 -19.96551 16.05833  1.000 21.72062 ? 131 ARG A H    1 
ATOM   1994 H HA   . ARG A 1 131 ? -19.25762 -17.95376 17.64244  1.000 23.28137 ? 131 ARG A HA   1 
ATOM   1995 H HB2  . ARG A 1 131 ? -19.56968 -17.88928 14.84037  1.000 28.35309 ? 131 ARG A HB2  1 
ATOM   1996 H HB3  . ARG A 1 131 ? -19.35702 -16.61168 15.76123  1.000 28.35309 ? 131 ARG A HB3  1 
ATOM   1997 H HG2  . ARG A 1 131 ? -17.37931 -18.52678 15.22875  1.000 24.49434 ? 131 ARG A HG2  1 
ATOM   1998 H HG3  . ARG A 1 131 ? -17.44323 -17.08142 14.57062  1.000 24.49434 ? 131 ARG A HG3  1 
ATOM   1999 H HD2  . ARG A 1 131 ? -16.73865 -17.71848 17.19548  1.000 30.36943 ? 131 ARG A HD2  1 
ATOM   2000 H HD3  . ARG A 1 131 ? -15.90196 -16.86317 16.14930  1.000 30.36943 ? 131 ARG A HD3  1 
ATOM   2001 H HE   . ARG A 1 131 ? -17.81137 -15.31000 16.64958  1.000 28.65555 ? 131 ARG A HE   1 
ATOM   2002 H HH11 . ARG A 1 131 ? -15.84182 -16.93272 18.74828  1.000 27.86484 ? 131 ARG A HH11 1 
ATOM   2003 H HH12 . ARG A 1 131 ? -15.94900 -15.95250 19.86384  1.000 27.86484 ? 131 ARG A HH12 1 
ATOM   2004 H HH21 . ARG A 1 131 ? -17.94916 -13.81315 18.34746  1.000 32.11358 ? 131 ARG A HH21 1 
ATOM   2005 H HH22 . ARG A 1 131 ? -17.22442 -14.06236 19.62356  1.000 32.11358 ? 131 ARG A HH22 1 
ATOM   2006 N N    . PRO A 1 132 ? -21.67225 -17.06255 17.42814  1.000 20.89679 ? 132 PRO A N    1 
ATOM   2007 C CA   . PRO A 1 132 ? -23.11945 -16.80869 17.39679  1.000 19.03079 ? 132 PRO A CA   1 
ATOM   2008 C C    . PRO A 1 132 ? -23.72183 -16.96131 16.01248  1.000 18.36154 ? 132 PRO A C    1 
ATOM   2009 O O    . PRO A 1 132 ? -24.88447 -17.35816 15.88582  1.000 24.21356 ? 132 PRO A O    1 
ATOM   2010 C CB   . PRO A 1 132 ? -23.20477 -15.35706 17.88965  1.000 18.70917 ? 132 PRO A CB   1 
ATOM   2011 C CG   . PRO A 1 132 ? -22.10019 -15.28580 18.89708  1.000 22.53435 ? 132 PRO A CG   1 
ATOM   2012 C CD   . PRO A 1 132 ? -20.96336 -16.02747 18.21503  1.000 25.83016 ? 132 PRO A CD   1 
ATOM   2013 H HA   . PRO A 1 132 ? -23.58320 -17.39544 18.01526  1.000 22.83695 ? 132 PRO A HA   1 
ATOM   2014 H HB2  . PRO A 1 132 ? -23.05701 -14.74049 17.15508  1.000 22.45100 ? 132 PRO A HB2  1 
ATOM   2015 H HB3  . PRO A 1 132 ? -24.06905 -15.18800 18.29645  1.000 22.45100 ? 132 PRO A HB3  1 
ATOM   2016 H HG2  . PRO A 1 132 ? -21.86399 -14.36172 19.07474  1.000 27.04122 ? 132 PRO A HG2  1 
ATOM   2017 H HG3  . PRO A 1 132 ? -22.36513 -15.72452 19.72072  1.000 27.04122 ? 132 PRO A HG3  1 
ATOM   2018 H HD2  . PRO A 1 132 ? -20.46062 -15.43372 17.63557  1.000 30.99620 ? 132 PRO A HD2  1 
ATOM   2019 H HD3  . PRO A 1 132 ? -20.37126 -16.43240 18.86899  1.000 30.99620 ? 132 PRO A HD3  1 
ATOM   2020 N N    . ASN A 1 133 ? -22.95871 -16.65206 14.96694  1.000 19.76579 ? 133 ASN A N    1 
ATOM   2021 C CA   . ASN A 1 133 ? -23.46610 -16.81062 13.60166  1.000 20.14883 ? 133 ASN A CA   1 
ATOM   2022 C C    . ASN A 1 133 ? -23.13982 -18.16300 13.00694  1.000 18.85375 ? 133 ASN A C    1 
ATOM   2023 O O    . ASN A 1 133 ? -23.22325 -18.32431 11.77881  1.000 19.01678 ? 133 ASN A O    1 
ATOM   2024 C CB   . ASN A 1 133 ? -22.94367 -15.69765 12.70353  1.000 18.67455 ? 133 ASN A CB   1 
ATOM   2025 C CG   . ASN A 1 133 ? -21.46447 -15.83231 12.42897  1.000 21.04068 ? 133 ASN A CG   1 
ATOM   2026 O OD1  . ASN A 1 133 ? -20.81589 -16.77108 12.90762  1.000 19.73548 ? 133 ASN A OD1  1 
ATOM   2027 N ND2  . ASN A 1 133 ? -20.92888 -14.94538 11.61671  1.000 22.52227 ? 133 ASN A ND2  1 
ATOM   2028 H H    . ASN A 1 133 ? -22.15397 -16.35245 15.02041  1.000 23.71895 ? 133 ASN A H    1 
ATOM   2029 H HA   . ASN A 1 133 ? -24.43218 -16.73041 13.63137  1.000 24.17859 ? 133 ASN A HA   1 
ATOM   2030 H HB2  . ASN A 1 133 ? -23.41235 -15.72550 11.85535  1.000 22.40945 ? 133 ASN A HB2  1 
ATOM   2031 H HB3  . ASN A 1 133 ? -23.09351 -14.84204 13.13701  1.000 22.40945 ? 133 ASN A HB3  1 
ATOM   2032 H HD21 . ASN A 1 133 ? -20.09079 -14.98260 11.42998  1.000 27.02672 ? 133 ASN A HD21 1 
ATOM   2033 H HD22 . ASN A 1 133 ? -21.41925 -14.32756 11.27191  1.000 27.02672 ? 133 ASN A HD22 1 
ATOM   2034 N N    . PHE A 1 134 ? -22.72736 -19.11119 13.84750  1.000 20.20139 ? 134 PHE A N    1 
ATOM   2035 C CA   . PHE A 1 134 ? -22.53111 -20.52282 13.50370  1.000 19.92402 ? 134 PHE A CA   1 
ATOM   2036 C C    . PHE A 1 134 ? -21.38158 -20.77032 12.55296  1.000 25.74455 ? 134 PHE A C    1 
ATOM   2037 O O    . PHE A 1 134 ? -21.35551 -21.78985 11.81734  1.000 28.13345 ? 134 PHE A O    1 
ATOM   2038 C CB   . PHE A 1 134 ? -23.80444 -21.09846 12.89890  1.000 20.30759 ? 134 PHE A CB   1 
ATOM   2039 C CG   . PHE A 1 134 ? -24.91862 -21.30395 13.87338  1.000 16.28990 ? 134 PHE A CG   1 
ATOM   2040 C CD1  . PHE A 1 134 ? -24.90611 -22.35250 14.77974  1.000 28.06327 ? 134 PHE A CD1  1 
ATOM   2041 C CD2  . PHE A 1 134 ? -25.98133 -20.43281 13.90154  1.000 23.81188 ? 134 PHE A CD2  1 
ATOM   2042 C CE1  . PHE A 1 134 ? -25.96126 -22.55288 15.65224  1.000 28.25204 ? 134 PHE A CE1  1 
ATOM   2043 C CE2  . PHE A 1 134 ? -27.03449 -20.61920 14.78705  1.000 25.87566 ? 134 PHE A CE2  1 
ATOM   2044 C CZ   . PHE A 1 134 ? -27.02795 -21.68273 15.65940  1.000 30.48478 ? 134 PHE A CZ   1 
ATOM   2045 H H    . PHE A 1 134 ? -22.54278 -18.95255 14.67167  1.000 24.24167 ? 134 PHE A H    1 
ATOM   2046 H HA   . PHE A 1 134 ? -22.31503 -20.99215 14.32349  1.000 23.90883 ? 134 PHE A HA   1 
ATOM   2047 H HB2  . PHE A 1 134 ? -24.12368 -20.49029 12.21416  1.000 24.36911 ? 134 PHE A HB2  1 
ATOM   2048 H HB3  . PHE A 1 134 ? -23.59762 -21.96105 12.50644  1.000 24.36911 ? 134 PHE A HB3  1 
ATOM   2049 H HD1  . PHE A 1 134 ? -24.17666 -22.92993 14.80164  1.000 33.67592 ? 134 PHE A HD1  1 
ATOM   2050 H HD2  . PHE A 1 134 ? -25.99570 -19.70846 13.31798  1.000 28.57425 ? 134 PHE A HD2  1 
ATOM   2051 H HE1  . PHE A 1 134 ? -25.94989 -23.27723 16.23480  1.000 33.90245 ? 134 PHE A HE1  1 
ATOM   2052 H HE2  . PHE A 1 134 ? -27.74697 -20.02077 14.79117  1.000 31.05079 ? 134 PHE A HE2  1 
ATOM   2053 H HZ   . PHE A 1 134 ? -27.73706 -21.81366 16.24707  1.000 36.58174 ? 134 PHE A HZ   1 
ATOM   2054 N N    . THR A 1 135 ? -20.43827 -19.87253 12.49384  1.000 18.95001 ? 135 THR A N    1 
ATOM   2055 C CA   . THR A 1 135 ? -19.19479 -20.18913 11.83508  1.000 21.51965 ? 135 THR A CA   1 
ATOM   2056 C C    . THR A 1 135 ? -18.18388 -20.55299 12.91122  1.000 19.20612 ? 135 THR A C    1 
ATOM   2057 O O    . THR A 1 135 ? -18.42543 -20.39793 14.11723  1.000 19.36375 ? 135 THR A O    1 
ATOM   2058 C CB   . THR A 1 135 ? -18.66842 -19.02721 11.01099  1.000 19.70964 ? 135 THR A CB   1 
ATOM   2059 O OG1  . THR A 1 135 ? -18.46061 -17.90356 11.85775  1.000 24.54788 ? 135 THR A OG1  1 
ATOM   2060 C CG2  . THR A 1 135 ? -19.66233 -18.65833 9.92686   1.000 19.31088 ? 135 THR A CG2  1 
ATOM   2061 H H    . THR A 1 135 ? -20.49002 -19.07977 12.82231  1.000 22.74001 ? 135 THR A H    1 
ATOM   2062 H HA   . THR A 1 135 ? -19.34598 -20.92788 11.22558  1.000 25.82358 ? 135 THR A HA   1 
ATOM   2063 H HB   . THR A 1 135 ? -17.83007 -19.27628 10.59113  1.000 23.65156 ? 135 THR A HB   1 
ATOM   2064 H HG1  . THR A 1 135 ? -19.17891 -17.69737 12.24263  1.000 29.45745 ? 135 THR A HG1  1 
ATOM   2065 H HG21 . THR A 1 135 ? -19.25761 -18.03262 9.30439   1.000 23.17306 ? 135 THR A HG21 1 
ATOM   2066 H HG22 . THR A 1 135 ? -19.93453 -19.45225 9.44128   1.000 23.17306 ? 135 THR A HG22 1 
ATOM   2067 H HG23 . THR A 1 135 ? -20.44680 -18.24620 10.32084  1.000 23.17306 ? 135 THR A HG23 1 
ATOM   2068 N N    . ILE A 1 136 ? -17.01039 -20.97078 12.46037  1.000 20.10108 ? 136 ILE A N    1 
ATOM   2069 C CA   . ILE A 1 136 ? -15.87358 -21.12243 13.36068  1.000 17.98821 ? 136 ILE A CA   1 
ATOM   2070 C C    . ILE A 1 136 ? -14.65480 -20.54604 12.67047  1.000 18.81366 ? 136 ILE A C    1 
ATOM   2071 O O    . ILE A 1 136 ? -14.55538 -20.52220 11.44352  1.000 20.27745 ? 136 ILE A O    1 
ATOM   2072 C CB   . ILE A 1 136 ? -15.66957 -22.58755 13.80785  1.000 28.50259 ? 136 ILE A CB   1 
ATOM   2073 C CG1  . ILE A 1 136 ? -15.09747 -23.50844 12.75448  1.000 27.13265 ? 136 ILE A CG1  1 
ATOM   2074 C CG2  . ILE A 1 136 ? -16.99722 -23.24791 14.30498  1.000 27.13241 ? 136 ILE A CG2  1 
ATOM   2075 C CD1  . ILE A 1 136 ? -14.74858 -24.87852 13.33976  1.000 26.49163 ? 136 ILE A CD1  1 
ATOM   2076 H H    . ILE A 1 136 ? -16.84594 -21.17215 11.64031  1.000 24.12130 ? 136 ILE A H    1 
ATOM   2077 H HA   . ILE A 1 136 ? -16.01928 -20.61105 14.17195  1.000 21.58585 ? 136 ILE A HA   1 
ATOM   2078 H HB   . ILE A 1 136 ? -15.02190 -22.49447 14.52414  1.000 34.20311 ? 136 ILE A HB   1 
ATOM   2079 H HG12 . ILE A 1 136 ? -15.75212 -23.63453 12.05018  1.000 32.55918 ? 136 ILE A HG12 1 
ATOM   2080 H HG13 . ILE A 1 136 ? -14.28865 -23.11557 12.39001  1.000 32.55918 ? 136 ILE A HG13 1 
ATOM   2081 H HG21 . ILE A 1 136 ? -16.78088 -23.96012 14.92761  1.000 32.55889 ? 136 ILE A HG21 1 
ATOM   2082 H HG22 . ILE A 1 136 ? -17.53792 -22.57561 14.74720  1.000 32.55889 ? 136 ILE A HG22 1 
ATOM   2083 H HG23 . ILE A 1 136 ? -17.47467 -23.60882 13.54258  1.000 32.55889 ? 136 ILE A HG23 1 
ATOM   2084 H HD11 . ILE A 1 136 ? -14.22196 -25.37371 12.69164  1.000 31.78996 ? 136 ILE A HD11 1 
ATOM   2085 H HD12 . ILE A 1 136 ? -14.23697 -24.75362 14.15402  1.000 31.78996 ? 136 ILE A HD12 1 
ATOM   2086 H HD13 . ILE A 1 136 ? -15.56927 -25.35730 13.53418  1.000 31.78996 ? 136 ILE A HD13 1 
ATOM   2087 N N    . LYS A 1 137 ? -13.74450 -20.02181 13.47811  1.000 25.84516 ? 137 LYS A N    1 
ATOM   2088 C CA   . LYS A 1 137 ? -12.50378 -19.44551 12.96990  1.000 27.28459 ? 137 LYS A CA   1 
ATOM   2089 C C    . LYS A 1 137 ? -11.42305 -20.48281 13.24065  1.000 27.92269 ? 137 LYS A C    1 
ATOM   2090 O O    . LYS A 1 137 ? -10.77841 -20.49995 14.30086  1.000 26.51578 ? 137 LYS A O    1 
ATOM   2091 C CB   . LYS A 1 137 ? -12.21507 -18.11669 13.63383  1.000 31.59660 ? 137 LYS A CB   1 
ATOM   2092 C CG   . LYS A 1 137 ? -13.47581 -17.27681 13.82790  1.000 29.29773 ? 137 LYS A CG   1 
ATOM   2093 C CD   . LYS A 1 137 ? -13.14499 -15.79455 13.83993  1.000 39.94407 ? 137 LYS A CD   1 
ATOM   2094 C CE   . LYS A 1 137 ? -14.15733 -15.00385 13.01806  1.000 48.31209 ? 137 LYS A CE   1 
ATOM   2095 N NZ   . LYS A 1 137 ? -13.76542 -13.57346 12.88708  1.000 54.84898 ? 137 LYS A NZ   1 
ATOM   2096 H H    . LYS A 1 137 ? -13.82183 -19.98640 14.33411  1.000 31.01420 ? 137 LYS A H    1 
ATOM   2097 H HA   . LYS A 1 137 ? -12.56057 -19.28296 12.01598  1.000 32.74151 ? 137 LYS A HA   1 
ATOM   2098 H HB2  . LYS A 1 137 ? -11.82125 -18.27591 14.50487  1.000 37.91592 ? 137 LYS A HB2  1 
ATOM   2099 H HB3  . LYS A 1 137 ? -11.59928 -17.61185 13.07835  1.000 37.91592 ? 137 LYS A HB3  1 
ATOM   2100 H HG2  . LYS A 1 137 ? -14.09341 -17.44785 13.10058  1.000 35.15728 ? 137 LYS A HG2  1 
ATOM   2101 H HG3  . LYS A 1 137 ? -13.88893 -17.50566 14.67561  1.000 35.15728 ? 137 LYS A HG3  1 
ATOM   2102 H HD2  . LYS A 1 137 ? -13.16558 -15.46513 14.75213  1.000 47.93288 ? 137 LYS A HD2  1 
ATOM   2103 H HD3  . LYS A 1 137 ? -12.26397 -15.65661 13.45733  1.000 47.93288 ? 137 LYS A HD3  1 
ATOM   2104 H HE2  . LYS A 1 137 ? -14.21571 -15.38535 12.12880  1.000 57.97451 ? 137 LYS A HE2  1 
ATOM   2105 H HE3  . LYS A 1 137 ? -15.02245 -15.04181 13.45373  1.000 57.97451 ? 137 LYS A HE3  1 
ATOM   2106 H HZ1  . LYS A 1 137 ? -14.37260 -13.13365 12.40814  1.000 65.81878 ? 137 LYS A HZ1  1 
ATOM   2107 H HZ2  . LYS A 1 137 ? -13.70501 -13.19891 13.69233  1.000 65.81878 ? 137 LYS A HZ2  1 
ATOM   2108 H HZ3  . LYS A 1 137 ? -12.97633 -13.51058 12.47940  1.000 65.81878 ? 137 LYS A HZ3  1 
ATOM   2109 N N    . GLY A 1 138 ? -11.22000 -21.36806 12.27317  1.000 28.18854 ? 138 GLY A N    1 
ATOM   2110 C CA   . GLY A 1 138 ? -10.37815 -22.52450 12.46276  1.000 24.64271 ? 138 GLY A CA   1 
ATOM   2111 C C    . GLY A 1 138 ? -9.05701  -22.38601 11.75331  1.000 24.80829 ? 138 GLY A C    1 
ATOM   2112 O O    . GLY A 1 138 ? -8.65073  -21.29443 11.33612  1.000 32.71338 ? 138 GLY A O    1 
ATOM   2113 H H    . GLY A 1 138 ? -11.56777 -21.31285 11.48808  1.000 33.82625 ? 138 GLY A H    1 
ATOM   2114 H HA2  . GLY A 1 138 ? -10.20738 -22.64695 13.40974  1.000 29.57125 ? 138 GLY A HA2  1 
ATOM   2115 H HA3  . GLY A 1 138 ? -10.82940 -23.31165 12.11911  1.000 29.57125 ? 138 GLY A HA3  1 
ATOM   2116 N N    . SER A 1 139 ? -8.36707  -23.51139 11.63186  1.000 22.80978 ? 139 SER A N    1 
ATOM   2117 C CA   . SER A 1 139 ? -7.19763  -23.67293 10.76817  1.000 17.37486 ? 139 SER A CA   1 
ATOM   2118 C C    . SER A 1 139 ? -7.46334  -24.94465 9.97129   1.000 27.39041 ? 139 SER A C    1 
ATOM   2119 O O    . SER A 1 139 ? -7.33965  -26.04887 10.49666  1.000 26.82430 ? 139 SER A O    1 
ATOM   2120 C CB   . SER A 1 139 ? -5.91884  -23.76541 11.57556  1.000 28.53498 ? 139 SER A CB   1 
ATOM   2121 O OG   . SER A 1 139 ? -4.85620  -24.20506 10.75667  1.000 37.03399 ? 139 SER A OG   1 
ATOM   2122 H H    . SER A 1 139 ? -8.56464  -24.23181 12.05834  1.000 27.37174 ? 139 SER A H    1 
ATOM   2123 H HA   . SER A 1 139 ? -7.09702  -22.91848 10.16767  1.000 20.84983 ? 139 SER A HA   1 
ATOM   2124 H HB2  . SER A 1 139 ? -5.70467  -22.88946 11.93218  1.000 34.24197 ? 139 SER A HB2  1 
ATOM   2125 H HB3  . SER A 1 139 ? -6.04560  -24.39795 12.30013  1.000 34.24197 ? 139 SER A HB3  1 
ATOM   2126 H HG   . SER A 1 139 ? -4.12251  -23.96267 11.08408  1.000 44.44078 ? 139 SER A HG   1 
ATOM   2127 N N    . PHE A 1 140 ? -7.89002  -24.78721 8.71724   1.000 26.14604 ? 140 PHE A N    1 
ATOM   2128 C CA   . PHE A 1 140 ? -8.31984  -25.89904 7.87840   1.000 29.18757 ? 140 PHE A CA   1 
ATOM   2129 C C    . PHE A 1 140 ? -7.81153  -25.65776 6.46073   1.000 31.61694 ? 140 PHE A C    1 
ATOM   2130 O O    . PHE A 1 140 ? -8.19010  -24.66467 5.82621   1.000 34.54398 ? 140 PHE A O    1 
ATOM   2131 C CB   . PHE A 1 140 ? -9.85072  -26.02722 7.81878   1.000 24.54601 ? 140 PHE A CB   1 
ATOM   2132 C CG   . PHE A 1 140 ? -10.52684 -26.43955 9.10529   1.000 23.67873 ? 140 PHE A CG   1 
ATOM   2133 C CD1  . PHE A 1 140 ? -10.41500 -27.72177 9.59954   1.000 23.38023 ? 140 PHE A CD1  1 
ATOM   2134 C CD2  . PHE A 1 140 ? -11.33578 -25.55360 9.75955   1.000 27.30200 ? 140 PHE A CD2  1 
ATOM   2135 C CE1  . PHE A 1 140 ? -11.09010 -28.10302 10.75007  1.000 24.27320 ? 140 PHE A CE1  1 
ATOM   2136 C CE2  . PHE A 1 140 ? -11.98989 -25.92584 10.91709  1.000 28.41195 ? 140 PHE A CE2  1 
ATOM   2137 C CZ   . PHE A 1 140 ? -11.87204 -27.21504 11.39434  1.000 26.35620 ? 140 PHE A CZ   1 
ATOM   2138 H H    . PHE A 1 140 ? -7.93849  -24.02501 8.32169   1.000 31.37525 ? 140 PHE A H    1 
ATOM   2139 H HA   . PHE A 1 140 ? -7.94432  -26.71397 8.24503   1.000 35.02509 ? 140 PHE A HA   1 
ATOM   2140 H HB2  . PHE A 1 140 ? -10.21831 -25.16636 7.56418   1.000 29.45521 ? 140 PHE A HB2  1 
ATOM   2141 H HB3  . PHE A 1 140 ? -10.07395 -26.69399 7.15029   1.000 29.45521 ? 140 PHE A HB3  1 
ATOM   2142 H HD1  . PHE A 1 140 ? -9.88035  -28.34007 9.15535   1.000 28.05628 ? 140 PHE A HD1  1 
ATOM   2143 H HD2  . PHE A 1 140 ? -11.44735 -24.69348 9.42304   1.000 32.76240 ? 140 PHE A HD2  1 
ATOM   2144 H HE1  . PHE A 1 140 ? -11.00453 -28.97015 11.07556  1.000 29.12784 ? 140 PHE A HE1  1 
ATOM   2145 H HE2  . PHE A 1 140 ? -12.50955 -25.30753 11.37629  1.000 34.09434 ? 140 PHE A HE2  1 
ATOM   2146 H HZ   . PHE A 1 140 ? -12.33210 -27.47088 12.16102  1.000 31.62744 ? 140 PHE A HZ   1 
ATOM   2147 N N    . LEU A 1 141 ? -6.97864  -26.55979 5.96047   1.000 35.08965 ? 141 LEU A N    1 
ATOM   2148 C CA   . LEU A 1 141 ? -6.46019  -26.51154 4.59968   1.000 31.21079 ? 141 LEU A CA   1 
ATOM   2149 C C    . LEU A 1 141 ? -7.21609  -27.51161 3.74180   1.000 38.37810 ? 141 LEU A C    1 
ATOM   2150 O O    . LEU A 1 141 ? -8.04264  -28.29257 4.22802   1.000 29.02566 ? 141 LEU A O    1 
ATOM   2151 C CB   . LEU A 1 141 ? -4.96694  -26.82235 4.59301   1.000 31.40237 ? 141 LEU A CB   1 
ATOM   2152 C CG   . LEU A 1 141 ? -4.05296  -25.90312 5.40590   1.000 36.19129 ? 141 LEU A CG   1 
ATOM   2153 C CD1  . LEU A 1 141 ? -2.67749  -26.54309 5.50799   1.000 42.40961 ? 141 LEU A CD1  1 
ATOM   2154 C CD2  . LEU A 1 141 ? -3.93183  -24.53263 4.77379   1.000 42.67834 ? 141 LEU A CD2  1 
ATOM   2155 H H    . LEU A 1 141 ? -6.68826  -27.23484 6.40715   1.000 42.10758 ? 141 LEU A H    1 
ATOM   2156 H HA   . LEU A 1 141 ? -6.58677  -25.62541 4.22418   1.000 37.45295 ? 141 LEU A HA   1 
ATOM   2157 H HB2  . LEU A 1 141 ? -4.84835  -27.71847 4.94450   1.000 37.68285 ? 141 LEU A HB2  1 
ATOM   2158 H HB3  . LEU A 1 141 ? -4.65865  -26.78254 3.67415   1.000 37.68285 ? 141 LEU A HB3  1 
ATOM   2159 H HG   . LEU A 1 141 ? -4.43337  -25.78097 6.28984   1.000 43.42954 ? 141 LEU A HG   1 
ATOM   2160 H HD11 . LEU A 1 141 ? -2.05613  -25.89782 5.87961   1.000 50.89154 ? 141 LEU A HD11 1 
ATOM   2161 H HD12 . LEU A 1 141 ? -2.73307  -27.31949 6.08650   1.000 50.89154 ? 141 LEU A HD12 1 
ATOM   2162 H HD13 . LEU A 1 141 ? -2.38696  -26.81031 4.62193   1.000 50.89154 ? 141 LEU A HD13 1 
ATOM   2163 H HD21 . LEU A 1 141 ? -3.21737  -24.04433 5.21134   1.000 51.21400 ? 141 LEU A HD21 1 
ATOM   2164 H HD22 . LEU A 1 141 ? -3.73141  -24.63689 3.82980   1.000 51.21400 ? 141 LEU A HD22 1 
ATOM   2165 H HD23 . LEU A 1 141 ? -4.77125  -24.05837 4.88279   1.000 51.21400 ? 141 LEU A HD23 1 
ATOM   2166 N N    . ASN A 1 142 ? -6.93967  -27.46359 2.43692   1.000 41.97638 ? 142 ASN A N    1 
ATOM   2167 C CA   . ASN A 1 142 ? -7.40753  -28.50140 1.53012   1.000 38.04741 ? 142 ASN A CA   1 
ATOM   2168 C C    . ASN A 1 142 ? -7.07763  -29.87349 2.10239   1.000 34.41284 ? 142 ASN A C    1 
ATOM   2169 O O    . ASN A 1 142 ? -5.94257  -30.13784 2.51163   1.000 32.22988 ? 142 ASN A O    1 
ATOM   2170 C CB   . ASN A 1 142 ? -6.76620  -28.30305 0.15947   1.000 44.66714 ? 142 ASN A CB   1 
ATOM   2171 C CG   . ASN A 1 142 ? -7.49350  -27.26526 -0.67149  1.000 58.78159 ? 142 ASN A CG   1 
ATOM   2172 O OD1  . ASN A 1 142 ? -8.33287  -26.52233 -0.15415  1.000 61.73780 ? 142 ASN A OD1  1 
ATOM   2173 N ND2  . ASN A 1 142 ? -7.13726  -27.16837 -1.95936  1.000 60.36440 ? 142 ASN A ND2  1 
ATOM   2174 H H    . ASN A 1 142 ? -6.48303  -26.84099 2.05747   1.000 50.37165 ? 142 ASN A H    1 
ATOM   2175 H HA   . ASN A 1 142 ? -8.36953  -28.44710 1.41481   1.000 45.65690 ? 142 ASN A HA   1 
ATOM   2176 H HB2  . ASN A 1 142 ? -5.84974  -28.00725 0.27794   1.000 53.60057 ? 142 ASN A HB2  1 
ATOM   2177 H HB3  . ASN A 1 142 ? -6.78369  -29.14358 -0.32420  1.000 53.60057 ? 142 ASN A HB3  1 
ATOM   2178 H HD21 . ASN A 1 142 ? -6.52243  -27.68085 -2.27462  1.000 72.43728 ? 142 ASN A HD21 1 
ATOM   2179 H HD22 . ASN A 1 142 ? -7.52219  -26.59386 -2.46987  1.000 72.43728 ? 142 ASN A HD22 1 
ATOM   2180 N N    . GLY A 1 143 ? -8.08797  -30.74034 2.16250   1.000 31.29793 ? 143 GLY A N    1 
ATOM   2181 C CA   . GLY A 1 143 ? -7.92012  -32.06255 2.73274   1.000 29.01043 ? 143 GLY A CA   1 
ATOM   2182 C C    . GLY A 1 143 ? -8.35052  -32.20379 4.18250   1.000 25.22933 ? 143 GLY A C    1 
ATOM   2183 O O    . GLY A 1 143 ? -8.39179  -33.33413 4.68279   1.000 29.55061 ? 143 GLY A O    1 
ATOM   2184 H H    . GLY A 1 143 ? -8.88199  -30.57879 1.87632   1.000 37.55752 ? 143 GLY A H    1 
ATOM   2185 H HA2  . GLY A 1 143 ? -8.44043  -32.69265 2.21017   1.000 34.81251 ? 143 GLY A HA2  1 
ATOM   2186 H HA3  . GLY A 1 143 ? -6.98290  -32.30578 2.67992   1.000 34.81251 ? 143 GLY A HA3  1 
ATOM   2187 N N    . SER A 1 144 ? -8.65063  -31.10845 4.86207   1.000 25.81777 ? 144 SER A N    1 
ATOM   2188 C CA   . SER A 1 144 ? -9.05908  -31.15964 6.26690   1.000 23.93510 ? 144 SER A CA   1 
ATOM   2189 C C    . SER A 1 144 ? -10.53489 -31.48192 6.43918   1.000 23.19740 ? 144 SER A C    1 
ATOM   2190 O O    . SER A 1 144 ? -10.97510 -31.71997 7.56787   1.000 18.54246 ? 144 SER A O    1 
ATOM   2191 C CB   . SER A 1 144 ? -8.72939  -29.81078 6.92384   1.000 26.43074 ? 144 SER A CB   1 
ATOM   2192 O OG   . SER A 1 144 ? -9.55402  -28.78111 6.39319   1.000 27.46379 ? 144 SER A OG   1 
ATOM   2193 H H    . SER A 1 144 ? -8.62714  -30.31423 4.53457   1.000 30.98132 ? 144 SER A H    1 
ATOM   2194 H HA   . SER A 1 144 ? -8.56369  -31.85353 6.72964   1.000 28.72212 ? 144 SER A HA   1 
ATOM   2195 H HB2  . SER A 1 144 ? -8.88167  -29.87849 7.87975   1.000 31.71689 ? 144 SER A HB2  1 
ATOM   2196 H HB3  . SER A 1 144 ? -7.79950  -29.59293 6.75031   1.000 31.71689 ? 144 SER A HB3  1 
ATOM   2197 H HG   . SER A 1 144 ? -9.35885  -28.64246 5.58834   1.000 32.95655 ? 144 SER A HG   1 
ATOM   2198 N N    . CYS A 1 145 ? -11.30649 -31.50286 5.34889   1.000 22.75090 ? 145 CYS A N    1 
ATOM   2199 C CA   . CYS A 1 145 ? -12.72831 -31.77806 5.46022   1.000 19.95744 ? 145 CYS A CA   1 
ATOM   2200 C C    . CYS A 1 145 ? -12.96643 -33.14963 6.07629   1.000 20.94605 ? 145 CYS A C    1 
ATOM   2201 O O    . CYS A 1 145 ? -12.25756 -34.11790 5.79894   1.000 19.68784 ? 145 CYS A O    1 
ATOM   2202 C CB   . CYS A 1 145 ? -13.40389 -31.69576 4.09303   1.000 20.69971 ? 145 CYS A CB   1 
ATOM   2203 S SG   . CYS A 1 145 ? -13.27392 -30.07620 3.35208   1.000 30.93052 ? 145 CYS A SG   1 
ATOM   2204 H H    . CYS A 1 145 ? -11.02932 -31.36115 4.54708   1.000 27.30108 ? 145 CYS A H    1 
ATOM   2205 H HA   . CYS A 1 145 ? -13.13204 -31.10974 6.03549   1.000 23.94893 ? 145 CYS A HA   1 
ATOM   2206 H HB2  . CYS A 1 145 ? -12.98417 -32.33406 3.49479   1.000 24.83965 ? 145 CYS A HB2  1 
ATOM   2207 H HB3  . CYS A 1 145 ? -14.34576 -31.90457 4.19457   1.000 24.83965 ? 145 CYS A HB3  1 
ATOM   2208 N N    . GLY A 1 146 ? -13.97768 -33.22497 6.94589   1.000 18.45781 ? 146 GLY A N    1 
ATOM   2209 C CA   . GLY A 1 146 ? -14.22701 -34.40964 7.70807   1.000 17.52355 ? 146 GLY A CA   1 
ATOM   2210 C C    . GLY A 1 146 ? -13.54044 -34.46493 9.06028   1.000 17.69169 ? 146 GLY A C    1 
ATOM   2211 O O    . GLY A 1 146 ? -13.88905 -35.32671 9.87962   1.000 21.00640 ? 146 GLY A O    1 
ATOM   2212 H H    . GLY A 1 146 ? -14.53025 -32.58451 7.10109   1.000 22.14937 ? 146 GLY A H    1 
ATOM   2213 H HA2  . GLY A 1 146 ? -15.18300 -34.48350 7.86069   1.000 21.02827 ? 146 GLY A HA2  1 
ATOM   2214 H HA3  . GLY A 1 146 ? -13.92922 -35.17609 7.19470   1.000 21.02827 ? 146 GLY A HA3  1 
ATOM   2215 N N    . SER A 1 147 ? -12.57822 -33.59132 9.30616   1.000 17.16245 ? 147 SER A N    1 
ATOM   2216 C CA   . SER A 1 147 ? -12.03886 -33.38371 10.64347  1.000 12.72829 ? 147 SER A CA   1 
ATOM   2217 C C    . SER A 1 147 ? -13.17450 -33.01421 11.60830  1.000 16.93974 ? 147 SER A C    1 
ATOM   2218 O O    . SER A 1 147 ? -14.12294 -32.30474 11.25140  1.000 17.69417 ? 147 SER A O    1 
ATOM   2219 C CB   . SER A 1 147 ? -11.01373 -32.27788 10.61652  1.000 23.82500 ? 147 SER A CB   1 
ATOM   2220 O OG   . SER A 1 147 ? -9.90918  -32.58346 9.74372   1.000 22.98809 ? 147 SER A OG   1 
ATOM   2221 H H    . SER A 1 147 ? -12.21241 -33.09565 8.70659   1.000 20.59494 ? 147 SER A H    1 
ATOM   2222 H HA   . SER A 1 147 ? -11.60833 -34.19356 10.96013  1.000 15.27395 ? 147 SER A HA   1 
ATOM   2223 H HB2  . SER A 1 147 ? -11.44127 -31.46602 10.30487  1.000 28.59000 ? 147 SER A HB2  1 
ATOM   2224 H HB3  . SER A 1 147 ? -10.67215 -32.14916 11.51572  1.000 28.59000 ? 147 SER A HB3  1 
ATOM   2225 H HG   . SER A 1 147 ? -10.08510 -32.33712 8.95981   1.000 27.58571 ? 147 SER A HG   1 
ATOM   2226 N N    . VAL A 1 148 ? -13.05059 -33.45488 12.85307  1.000 17.79492 ? 148 VAL A N    1 
ATOM   2227 C CA   . VAL A 1 148 ? -14.19299 -33.34033 13.73574  1.000 16.08917 ? 148 VAL A CA   1 
ATOM   2228 C C    . VAL A 1 148 ? -13.85207 -32.54183 14.99135  1.000 15.14513 ? 148 VAL A C    1 
ATOM   2229 O O    . VAL A 1 148 ? -12.69333 -32.38015 15.37386  1.000 17.52995 ? 148 VAL A O    1 
ATOM   2230 C CB   . VAL A 1 148 ? -14.78802 -34.71803 14.10268  1.000 17.57475 ? 148 VAL A CB   1 
ATOM   2231 C CG1  . VAL A 1 148 ? -15.20800 -35.46962 12.89607  1.000 19.63991 ? 148 VAL A CG1  1 
ATOM   2232 C CG2  . VAL A 1 148 ? -13.81766 -35.54378 14.94852  1.000 21.20401 ? 148 VAL A CG2  1 
ATOM   2233 H H    . VAL A 1 148 ? -12.34342 -33.80852 13.19111  1.000 21.35390 ? 148 VAL A H    1 
ATOM   2234 H HA   . VAL A 1 148 ? -14.86524 -32.82058 13.26682  1.000 19.30701 ? 148 VAL A HA   1 
ATOM   2235 H HB   . VAL A 1 148 ? -15.57934 -34.55799 14.63950  1.000 21.08969 ? 148 VAL A HB   1 
ATOM   2236 H HG11 . VAL A 1 148 ? -15.66345 -36.28016 13.17241  1.000 23.56789 ? 148 VAL A HG11 1 
ATOM   2237 H HG12 . VAL A 1 148 ? -15.80625 -34.91577 12.37120  1.000 23.56789 ? 148 VAL A HG12 1 
ATOM   2238 H HG13 . VAL A 1 148 ? -14.42164 -35.69267 12.37421  1.000 23.56789 ? 148 VAL A HG13 1 
ATOM   2239 H HG21 . VAL A 1 148 ? -14.19702 -36.42417 15.09584  1.000 25.44481 ? 148 VAL A HG21 1 
ATOM   2240 H HG22 . VAL A 1 148 ? -12.97443 -35.62282 14.47476  1.000 25.44481 ? 148 VAL A HG22 1 
ATOM   2241 H HG23 . VAL A 1 148 ? -13.67932 -35.09719 15.79784  1.000 25.44481 ? 148 VAL A HG23 1 
ATOM   2242 N N    . GLY A 1 149 ? -14.90074 -31.95002 15.56435  1.000 14.48115 ? 149 GLY A N    1 
ATOM   2243 C CA   . GLY A 1 149 ? -14.82076 -31.23073 16.82382  1.000 15.50429 ? 149 GLY A CA   1 
ATOM   2244 C C    . GLY A 1 149 ? -15.52949 -32.04295 17.89007  1.000 17.61617 ? 149 GLY A C    1 
ATOM   2245 O O    . GLY A 1 149 ? -16.45380 -32.78352 17.61329  1.000 16.27987 ? 149 GLY A O    1 
ATOM   2246 H H    . GLY A 1 149 ? -15.69162 -31.95544 15.22807  1.000 17.37738 ? 149 GLY A H    1 
ATOM   2247 H HA2  . GLY A 1 149 ? -13.89395 -31.10315 17.07923  1.000 18.60514 ? 149 GLY A HA2  1 
ATOM   2248 H HA3  . GLY A 1 149 ? -15.24842 -30.36402 16.74321  1.000 18.60514 ? 149 GLY A HA3  1 
ATOM   2249 N N    . PHE A 1 150 ? -15.05500 -31.94033 19.11430  1.000 16.53214 ? 150 PHE A N    1 
ATOM   2250 C CA   . PHE A 1 150 ? -15.58670 -32.78841 20.17359  1.000 16.34271 ? 150 PHE A CA   1 
ATOM   2251 C C    . PHE A 1 150 ? -15.32970 -32.14003 21.51908  1.000 18.68483 ? 150 PHE A C    1 
ATOM   2252 O O    . PHE A 1 150 ? -14.48445 -31.25744 21.65293  1.000 18.32391 ? 150 PHE A O    1 
ATOM   2253 C CB   . PHE A 1 150 ? -14.96258 -34.19491 20.17394  1.000 18.88841 ? 150 PHE A CB   1 
ATOM   2254 C CG   . PHE A 1 150 ? -13.51467 -34.17187 20.35447  1.000 15.70846 ? 150 PHE A CG   1 
ATOM   2255 C CD1  . PHE A 1 150 ? -12.68356 -33.84256 19.30897  1.000 19.00004 ? 150 PHE A CD1  1 
ATOM   2256 C CD2  . PHE A 1 150 ? -12.96499 -34.33321 21.62156  1.000 18.52754 ? 150 PHE A CD2  1 
ATOM   2257 C CE1  . PHE A 1 150 ? -11.32569 -33.74658 19.46450  1.000 22.02585 ? 150 PHE A CE1  1 
ATOM   2258 C CE2  . PHE A 1 150 ? -11.60412 -34.23323 21.78611  1.000 25.83889 ? 150 PHE A CE2  1 
ATOM   2259 C CZ   . PHE A 1 150 ? -10.77398 -33.93691 20.71858  1.000 25.80483 ? 150 PHE A CZ   1 
ATOM   2260 H H    . PHE A 1 150 ? -14.43352 -31.39799 19.35886  1.000 19.83857 ? 150 PHE A H    1 
ATOM   2261 H HA   . PHE A 1 150 ? -16.54359 -32.86608 20.03121  1.000 19.61125 ? 150 PHE A HA   1 
ATOM   2262 H HB2  . PHE A 1 150 ? -15.34743 -34.71067 20.90049  1.000 22.66610 ? 150 PHE A HB2  1 
ATOM   2263 H HB3  . PHE A 1 150 ? -15.15294 -34.62454 19.32561  1.000 22.66610 ? 150 PHE A HB3  1 
ATOM   2264 H HD1  . PHE A 1 150 ? -13.05439 -33.68034 18.47094  1.000 22.80005 ? 150 PHE A HD1  1 
ATOM   2265 H HD2  . PHE A 1 150 ? -13.51411 -34.50710 22.35226  1.000 22.23305 ? 150 PHE A HD2  1 
ATOM   2266 H HE1  . PHE A 1 150 ? -10.78158 -33.55470 18.73581  1.000 26.43103 ? 150 PHE A HE1  1 
ATOM   2267 H HE2  . PHE A 1 150 ? -11.23431 -34.36646 22.62916  1.000 31.00667 ? 150 PHE A HE2  1 
ATOM   2268 H HZ   . PHE A 1 150 ? -9.85508  -33.86626 20.84395  1.000 30.96580 ? 150 PHE A HZ   1 
ATOM   2269 N N    . ASN A 1 151 ? -16.08267 -32.61223 22.49753  1.000 15.47084 ? 151 ASN A N    1 
ATOM   2270 C CA   . ASN A 1 151 ? -15.78232 -32.42487 23.91375  1.000 20.15874 ? 151 ASN A CA   1 
ATOM   2271 C C    . ASN A 1 151 ? -15.64947 -33.78618 24.59496  1.000 21.21801 ? 151 ASN A C    1 
ATOM   2272 O O    . ASN A 1 151 ? -16.18650 -34.80133 24.13914  1.000 23.44254 ? 151 ASN A O    1 
ATOM   2273 C CB   . ASN A 1 151 ? -16.88819 -31.62417 24.59285  1.000 23.16399 ? 151 ASN A CB   1 
ATOM   2274 C CG   . ASN A 1 151 ? -16.84127 -30.13293 24.27479  1.000 21.61814 ? 151 ASN A CG   1 
ATOM   2275 O OD1  . ASN A 1 151 ? -16.11611 -29.35976 24.92652  1.000 32.08803 ? 151 ASN A OD1  1 
ATOM   2276 N ND2  . ASN A 1 151 ? -17.59323 -29.72591 23.26077  1.000 23.87304 ? 151 ASN A ND2  1 
ATOM   2277 H H    . ASN A 1 151 ? -16.80326 -33.06273 22.36499  1.000 18.56501 ? 151 ASN A H    1 
ATOM   2278 H HA   . ASN A 1 151 ? -14.94173 -31.94926 24.01234  1.000 24.19049 ? 151 ASN A HA   1 
ATOM   2279 H HB2  . ASN A 1 151 ? -17.74782 -31.96367 24.29734  1.000 27.79679 ? 151 ASN A HB2  1 
ATOM   2280 H HB3  . ASN A 1 151 ? -16.80445 -31.72569 25.55382  1.000 27.79679 ? 151 ASN A HB3  1 
ATOM   2281 H HD21 . ASN A 1 151 ? -17.60282 -28.89478 23.03928  1.000 28.64765 ? 151 ASN A HD21 1 
ATOM   2282 H HD22 . ASN A 1 151 ? -18.07063 -30.29302 22.82425  1.000 28.64765 ? 151 ASN A HD22 1 
ATOM   2283 N N    . ILE A 1 152 ? -14.96685 -33.82035 25.74518  1.000 22.31706 ? 152 ILE A N    1 
ATOM   2284 C CA   . ILE A 1 152 ? -14.88415 -35.05176 26.52445  1.000 24.08982 ? 152 ILE A CA   1 
ATOM   2285 C C    . ILE A 1 152 ? -15.48585 -34.78109 27.90040  1.000 26.75931 ? 152 ILE A C    1 
ATOM   2286 O O    . ILE A 1 152 ? -15.21789 -33.73624 28.49414  1.000 25.39683 ? 152 ILE A O    1 
ATOM   2287 C CB   . ILE A 1 152 ? -13.43978 -35.56168 26.62464  1.000 28.75105 ? 152 ILE A CB   1 
ATOM   2288 C CG1  . ILE A 1 152 ? -12.83919 -35.67833 25.21778  1.000 32.08470 ? 152 ILE A CG1  1 
ATOM   2289 C CG2  . ILE A 1 152 ? -13.40191 -36.91801 27.21682  1.000 33.95157 ? 152 ILE A CG2  1 
ATOM   2290 C CD1  . ILE A 1 152 ? -11.44769 -36.27318 25.14691  1.000 32.14443 ? 152 ILE A CD1  1 
ATOM   2291 H H    . ILE A 1 152 ? -14.55051 -33.14923 26.08674  1.000 26.78047 ? 152 ILE A H    1 
ATOM   2292 H HA   . ILE A 1 152 ? -15.41144 -35.74592 26.09983  1.000 28.90778 ? 152 ILE A HA   1 
ATOM   2293 H HB   . ILE A 1 152 ? -12.94647 -34.93462 27.17620  1.000 34.50126 ? 152 ILE A HB   1 
ATOM   2294 H HG12 . ILE A 1 152 ? -13.42155 -36.24247 24.68423  1.000 38.50164 ? 152 ILE A HG12 1 
ATOM   2295 H HG13 . ILE A 1 152 ? -12.79276 -34.79005 24.83134  1.000 38.50164 ? 152 ILE A HG13 1 
ATOM   2296 H HG21 . ILE A 1 152 ? -12.48180 -37.14741 27.42300  1.000 40.74188 ? 152 ILE A HG21 1 
ATOM   2297 H HG22 . ILE A 1 152 ? -13.93419 -36.92493 28.02663  1.000 40.74188 ? 152 ILE A HG22 1 
ATOM   2298 H HG23 . ILE A 1 152 ? -13.76417 -37.55191 26.57730  1.000 40.74188 ? 152 ILE A HG23 1 
ATOM   2299 H HD11 . ILE A 1 152 ? -11.06653 -36.08234 24.27516  1.000 38.57332 ? 152 ILE A HD11 1 
ATOM   2300 H HD12 . ILE A 1 152 ? -10.89925 -35.87717 25.84134  1.000 38.57332 ? 152 ILE A HD12 1 
ATOM   2301 H HD13 . ILE A 1 152 ? -11.50697 -37.23231 25.27929  1.000 38.57332 ? 152 ILE A HD13 1 
ATOM   2302 N N    . ASP A 1 153 ? -16.34228 -35.70606 28.36353  1.000 38.22948 ? 153 ASP A N    1 
ATOM   2303 C CA   . ASP A 1 153 ? -17.00777 -35.67040 29.67932  1.000 35.03544 ? 153 ASP A CA   1 
ATOM   2304 C C    . ASP A 1 153 ? -16.71997 -36.99261 30.39260  1.000 40.35682 ? 153 ASP A C    1 
ATOM   2305 O O    . ASP A 1 153 ? -17.44213 -37.98109 30.23274  1.000 47.34814 ? 153 ASP A O    1 
ATOM   2306 C CB   . ASP A 1 153 ? -18.50992 -35.42152 29.55394  1.000 37.92183 ? 153 ASP A CB   1 
ATOM   2307 H H    . ASP A 1 153 ? -16.56456 -36.40096 27.91002  1.000 45.87537 ? 153 ASP A H    1 
ATOM   2308 H HA   . ASP A 1 153 ? -16.62153 -34.94441 30.19390  1.000 42.04253 ? 153 ASP A HA   1 
ATOM   2309 N N    . TYR A 1 154 ? -15.66626 -36.98427 31.20398  1.000 41.94618 ? 154 TYR A N    1 
ATOM   2310 C CA   . TYR A 1 154 ? -15.11654 -38.16922 31.83644  1.000 47.35361 ? 154 TYR A CA   1 
ATOM   2311 C C    . TYR A 1 154 ? -14.60139 -39.15818 30.80901  1.000 43.25794 ? 154 TYR A C    1 
ATOM   2312 O O    . TYR A 1 154 ? -13.50032 -39.01197 30.27049  1.000 46.50432 ? 154 TYR A O    1 
ATOM   2313 C CB   . TYR A 1 154 ? -16.15429 -38.87558 32.70364  1.000 59.09695 ? 154 TYR A CB   1 
ATOM   2314 H H    . TYR A 1 154 ? -15.23490 -36.27005 31.41057  1.000 50.33542 ? 154 TYR A H    1 
ATOM   2315 H HA   . TYR A 1 154 ? -14.38297 -37.87699 32.39988  1.000 56.82433 ? 154 TYR A HA   1 
ATOM   2316 N N    . ASP A 1 155 ? -15.39448 -40.19466 30.55810  1.000 42.19800 ? 155 ASP A N    1 
ATOM   2317 C CA   . ASP A 1 155 ? -15.01131 -41.25479 29.64358  1.000 48.11581 ? 155 ASP A CA   1 
ATOM   2318 C C    . ASP A 1 155 ? -15.62595 -41.09342 28.25646  1.000 34.61550 ? 155 ASP A C    1 
ATOM   2319 O O    . ASP A 1 155 ? -15.25504 -41.84057 27.35113  1.000 37.22078 ? 155 ASP A O    1 
ATOM   2320 C CB   . ASP A 1 155 ? -15.43144 -42.61148 30.22659  1.000 48.89993 ? 155 ASP A CB   1 
ATOM   2321 H H    . ASP A 1 155 ? -16.17052 -40.30449 30.91175  1.000 50.63760 ? 155 ASP A H    1 
ATOM   2322 H HA   . ASP A 1 155 ? -14.04728 -41.25096 29.53992  1.000 57.73897 ? 155 ASP A HA   1 
ATOM   2323 N N    . CYS A 1 156 ? -16.52265 -40.13303 28.07673  1.000 29.21093 ? 156 CYS A N    1 
ATOM   2324 C CA   . CYS A 1 156 ? -17.40827 -40.09903 26.92944  1.000 30.81202 ? 156 CYS A CA   1 
ATOM   2325 C C    . CYS A 1 156 ? -17.04686 -38.94917 26.00428  1.000 30.90166 ? 156 CYS A C    1 
ATOM   2326 O O    . CYS A 1 156 ? -16.92293 -37.79934 26.44803  1.000 31.14741 ? 156 CYS A O    1 
ATOM   2327 C CB   . CYS A 1 156 ? -18.86454 -39.96346 27.38001  1.000 32.11188 ? 156 CYS A CB   1 
ATOM   2328 S SG   . CYS A 1 156 ? -20.03804 -39.98856 26.02658  1.000 35.48873 ? 156 CYS A SG   1 
ATOM   2329 H H    . CYS A 1 156 ? -16.63637 -39.47545 28.61910  1.000 35.05312 ? 156 CYS A H    1 
ATOM   2330 H HA   . CYS A 1 156 ? -17.30144 -40.92363 26.42897  1.000 36.97442 ? 156 CYS A HA   1 
ATOM   2331 H HB2  . CYS A 1 156 ? -19.07816 -40.70100 27.97248  1.000 38.53425 ? 156 CYS A HB2  1 
ATOM   2332 H HB3  . CYS A 1 156 ? -18.96938 -39.12083 27.84850  1.000 38.53425 ? 156 CYS A HB3  1 
ATOM   2333 H HG   . CYS A 1 156 ? -21.13836 -39.78471 26.46032  1.000 42.58647 ? 156 CYS A HG   1 
ATOM   2334 N N    . VAL A 1 157 ? -16.91816 -39.25927 24.71313  1.000 31.72580 ? 157 VAL A N    1 
ATOM   2335 C CA   . VAL A 1 157 ? -16.57358 -38.27637 23.69986  1.000 26.61884 ? 157 VAL A CA   1 
ATOM   2336 C C    . VAL A 1 157 ? -17.87171 -37.83701 23.05867  1.000 21.68584 ? 157 VAL A C    1 
ATOM   2337 O O    . VAL A 1 157 ? -18.60385 -38.65824 22.49591  1.000 24.93773 ? 157 VAL A O    1 
ATOM   2338 C CB   . VAL A 1 157 ? -15.61876 -38.84096 22.64085  1.000 24.05707 ? 157 VAL A CB   1 
ATOM   2339 C CG1  . VAL A 1 157 ? -15.38021 -37.78810 21.55358  1.000 22.75202 ? 157 VAL A CG1  1 
ATOM   2340 C CG2  . VAL A 1 157 ? -14.31862 -39.30232 23.28302  1.000 25.65661 ? 157 VAL A CG2  1 
ATOM   2341 H H    . VAL A 1 157 ? -17.02842 -40.05216 24.39861  1.000 38.07096 ? 157 VAL A H    1 
ATOM   2342 H HA   . VAL A 1 157 ? -16.13633 -37.52028 24.12148  1.000 31.94261 ? 157 VAL A HA   1 
ATOM   2343 H HB   . VAL A 1 157 ? -16.01399 -39.62001 22.21923  1.000 28.86849 ? 157 VAL A HB   1 
ATOM   2344 H HG11 . VAL A 1 157 ? -14.63779 -38.07116 20.99867  1.000 27.30242 ? 157 VAL A HG11 1 
ATOM   2345 H HG12 . VAL A 1 157 ? -16.18309 -37.70340 21.01535  1.000 27.30242 ? 157 VAL A HG12 1 
ATOM   2346 H HG13 . VAL A 1 157 ? -15.17404 -36.94019 21.97618  1.000 27.30242 ? 157 VAL A HG13 1 
ATOM   2347 H HG21 . VAL A 1 157 ? -13.69816 -39.56739 22.58608  1.000 30.78793 ? 157 VAL A HG21 1 
ATOM   2348 H HG22 . VAL A 1 157 ? -13.94438 -38.57134 23.79861  1.000 30.78793 ? 157 VAL A HG22 1 
ATOM   2349 H HG23 . VAL A 1 157 ? -14.50422 -40.05682 23.86449  1.000 30.78793 ? 157 VAL A HG23 1 
ATOM   2350 N N    . SER A 1 158 ? -18.17576 -36.56231 23.16035  1.000 25.15902 ? 158 SER A N    1 
ATOM   2351 C CA   . SER A 1 158 ? -19.36399 -35.98987 22.53729  1.000 27.06308 ? 158 SER A CA   1 
ATOM   2352 C C    . SER A 1 158 ? -18.88011 -35.28472 21.28989  1.000 18.73347 ? 158 SER A C    1 
ATOM   2353 O O    . SER A 1 158 ? -18.20598 -34.24825 21.39677  1.000 18.59493 ? 158 SER A O    1 
ATOM   2354 C CB   . SER A 1 158 ? -20.06809 -35.02702 23.48463  1.000 27.21399 ? 158 SER A CB   1 
ATOM   2355 O OG   . SER A 1 158 ? -20.79085 -35.76219 24.46092  1.000 25.90855 ? 158 SER A OG   1 
ATOM   2356 H H    . SER A 1 158 ? -17.70237 -35.99020 23.59387  1.000 30.19083 ? 158 SER A H    1 
ATOM   2357 H HA   . SER A 1 158 ? -20.00236 -36.68124 22.30163  1.000 32.47569 ? 158 SER A HA   1 
ATOM   2358 H HB2  . SER A 1 158 ? -19.40769 -34.47076 23.92621  1.000 32.65679 ? 158 SER A HB2  1 
ATOM   2359 H HB3  . SER A 1 158 ? -20.68436 -34.47320 22.97975  1.000 32.65679 ? 158 SER A HB3  1 
ATOM   2360 H HG   . SER A 1 158 ? -21.30041 -35.24886 24.88806  1.000 31.09027 ? 158 SER A HG   1 
ATOM   2361 N N    . PHE A 1 159 ? -19.18723 -35.87324 20.11742  1.000 20.57672 ? 159 PHE A N    1 
ATOM   2362 C CA   . PHE A 1 159 ? -18.81622 -35.31515 18.82389  1.000 22.63719 ? 159 PHE A CA   1 
ATOM   2363 C C    . PHE A 1 159 ? -19.85391 -34.28375 18.45516  1.000 19.71441 ? 159 PHE A C    1 
ATOM   2364 O O    . PHE A 1 159 ? -21.06173 -34.54275 18.52458  1.000 23.93852 ? 159 PHE A O    1 
ATOM   2365 C CB   . PHE A 1 159 ? -18.78498 -36.38445 17.73225  1.000 16.57739 ? 159 PHE A CB   1 
ATOM   2366 C CG   . PHE A 1 159 ? -17.69127 -37.35469 17.90303  1.000 22.70010 ? 159 PHE A CG   1 
ATOM   2367 C CD1  . PHE A 1 159 ? -16.38741 -37.01442 17.53270  1.000 15.22351 ? 159 PHE A CD1  1 
ATOM   2368 C CD2  . PHE A 1 159 ? -17.92647 -38.60621 18.45118  1.000 21.26212 ? 159 PHE A CD2  1 
ATOM   2369 C CE1  . PHE A 1 159 ? -15.35176 -37.90670 17.70952  1.000 16.63500 ? 159 PHE A CE1  1 
ATOM   2370 C CE2  . PHE A 1 159 ? -16.90683 -39.49052 18.64799  1.000 17.18153 ? 159 PHE A CE2  1 
ATOM   2371 C CZ   . PHE A 1 159 ? -15.60498 -39.14326 18.28167  1.000 20.70196 ? 159 PHE A CZ   1 
ATOM   2372 H H    . PHE A 1 159 ? -19.62062 -36.61355 20.05381  1.000 24.69207 ? 159 PHE A H    1 
ATOM   2373 H HA   . PHE A 1 159 ? -17.92955 -34.92648 18.88345  1.000 27.16462 ? 159 PHE A HA   1 
ATOM   2374 H HB2  . PHE A 1 159 ? -19.62260 -36.87313 17.74665  1.000 19.89287 ? 159 PHE A HB2  1 
ATOM   2375 H HB3  . PHE A 1 159 ? -18.66802 -35.95083 16.87155  1.000 19.89287 ? 159 PHE A HB3  1 
ATOM   2376 H HD1  . PHE A 1 159 ? -16.21594 -36.17806 17.16428  1.000 18.26821 ? 159 PHE A HD1  1 
ATOM   2377 H HD2  . PHE A 1 159 ? -18.79336 -38.84605 18.68772  1.000 25.51454 ? 159 PHE A HD2  1 
ATOM   2378 H HE1  . PHE A 1 159 ? -14.48985 -37.67986 17.44596  1.000 19.96200 ? 159 PHE A HE1  1 
ATOM   2379 H HE2  . PHE A 1 159 ? -17.07830 -40.32289 19.02442  1.000 20.61784 ? 159 PHE A HE2  1 
ATOM   2380 H HZ   . PHE A 1 159 ? -14.90755 -39.74179 18.42254  1.000 24.84235 ? 159 PHE A HZ   1 
ATOM   2381 N N    . CYS A 1 160 ? -19.40373 -33.10719 18.14105  1.000 16.19124 ? 160 CYS A N    1 
ATOM   2382 C CA   . CYS A 1 160 ? -20.33744 -32.07574 17.81335  1.000 19.05912 ? 160 CYS A CA   1 
ATOM   2383 C C    . CYS A 1 160 ? -20.12248 -31.42774 16.47383  1.000 17.39382 ? 160 CYS A C    1 
ATOM   2384 O O    . CYS A 1 160 ? -21.00990 -30.70616 16.01996  1.000 21.61391 ? 160 CYS A O    1 
ATOM   2385 C CB   . CYS A 1 160 ? -20.31568 -30.99338 18.88703  1.000 19.89435 ? 160 CYS A CB   1 
ATOM   2386 S SG   . CYS A 1 160 ? -18.71933 -30.28726 19.12703  1.000 21.97874 ? 160 CYS A SG   1 
ATOM   2387 H H    . CYS A 1 160 ? -18.57390 -32.88252 18.11148  1.000 19.42949 ? 160 CYS A H    1 
ATOM   2388 H HA   . CYS A 1 160 ? -21.22211 -32.47443 17.79280  1.000 22.87094 ? 160 CYS A HA   1 
ATOM   2389 H HB2  . CYS A 1 160 ? -20.92115 -30.28170 18.62625  1.000 23.87322 ? 160 CYS A HB2  1 
ATOM   2390 H HB3  . CYS A 1 160 ? -20.60167 -31.38013 19.72869  1.000 23.87322 ? 160 CYS A HB3  1 
ATOM   2391 H HG   . CYS A 1 160 ? -18.78329 -29.46384 19.99751  1.000 26.37449 ? 160 CYS A HG   1 
ATOM   2392 N N    . TYR A 1 161 ? -19.00707 -31.64745 15.81709  1.000 15.16931 ? 161 TYR A N    1 
ATOM   2393 C CA   . TYR A 1 161 ? -18.75225 -30.89149 14.60164  1.000 16.06112 ? 161 TYR A CA   1 
ATOM   2394 C C    . TYR A 1 161 ? -18.01922 -31.73429 13.60138  1.000 16.91763 ? 161 TYR A C    1 
ATOM   2395 O O    . TYR A 1 161 ? -17.10179 -32.43979 13.96827  1.000 14.52478 ? 161 TYR A O    1 
ATOM   2396 C CB   . TYR A 1 161 ? -17.88833 -29.65598 14.87871  1.000 17.51284 ? 161 TYR A CB   1 
ATOM   2397 C CG   . TYR A 1 161 ? -17.59259 -28.78999 13.66935  1.000 15.86757 ? 161 TYR A CG   1 
ATOM   2398 C CD1  . TYR A 1 161 ? -18.51217 -27.85444 13.21260  1.000 21.08779 ? 161 TYR A CD1  1 
ATOM   2399 C CD2  . TYR A 1 161 ? -16.37133 -28.83464 13.04675  1.000 14.58726 ? 161 TYR A CD2  1 
ATOM   2400 C CE1  . TYR A 1 161 ? -18.22145 -27.02055 12.13322  1.000 20.94086 ? 161 TYR A CE1  1 
ATOM   2401 C CE2  . TYR A 1 161 ? -16.05061 -28.02374 12.00236  1.000 17.53681 ? 161 TYR A CE2  1 
ATOM   2402 C CZ   . TYR A 1 161 ? -16.99214 -27.13318 11.50958  1.000 17.98224 ? 161 TYR A CZ   1 
ATOM   2403 O OH   . TYR A 1 161 ? -16.68743 -26.30529 10.45420  1.000 20.80564 ? 161 TYR A OH   1 
ATOM   2404 H H    . TYR A 1 161 ? -18.39671 -32.21010 16.04296  1.000 18.20317 ? 161 TYR A H    1 
ATOM   2405 H HA   . TYR A 1 161 ? -19.61132 -30.63195 14.23350  1.000 19.27335 ? 161 TYR A HA   1 
ATOM   2406 H HB2  . TYR A 1 161 ? -18.34800 -29.10074 15.52789  1.000 21.01541 ? 161 TYR A HB2  1 
ATOM   2407 H HB3  . TYR A 1 161 ? -17.03822 -29.95152 15.23883  1.000 21.01541 ? 161 TYR A HB3  1 
ATOM   2408 H HD1  . TYR A 1 161 ? -19.33838 -27.78336 13.63435  1.000 25.30535 ? 161 TYR A HD1  1 
ATOM   2409 H HD2  . TYR A 1 161 ? -15.73696 -29.44332 13.35060  1.000 17.50471 ? 161 TYR A HD2  1 
ATOM   2410 H HE1  . TYR A 1 161 ? -18.84485 -26.39686 11.83738  1.000 25.12903 ? 161 TYR A HE1  1 
ATOM   2411 H HE2  . TYR A 1 161 ? -15.20344 -28.06583 11.62064  1.000 21.04418 ? 161 TYR A HE2  1 
ATOM   2412 H HH   . TYR A 1 161 ? -16.03990 -25.80990 10.65573  1.000 24.96677 ? 161 TYR A HH   1 
ATOM   2413 N N    . MET A 1 162 ? -18.43985 -31.64285 12.34429  1.000 13.81908 ? 162 MET A N    1 
ATOM   2414 C CA   . MET A 1 162 ? -17.66305 -32.14353 11.20525  1.000 19.32485 ? 162 MET A CA   1 
ATOM   2415 C C    . MET A 1 162 ? -17.44162 -30.99776 10.23504  1.000 16.91303 ? 162 MET A C    1 
ATOM   2416 O O    . MET A 1 162 ? -18.39303 -30.30227 9.83713   1.000 15.54915 ? 162 MET A O    1 
ATOM   2417 C CB   . MET A 1 162 ? -18.37090 -33.25764 10.46732  1.000 17.21252 ? 162 MET A CB   1 
ATOM   2418 C CG   . MET A 1 162 ? -17.56511 -33.84867 9.29913   1.000 16.27331 ? 162 MET A CG   1 
ATOM   2419 S SD   . MET A 1 162 ? -18.09738 -35.54017 8.91664   1.000 22.79149 ? 162 MET A SD   1 
ATOM   2420 C CE   . MET A 1 162 ? -17.18170 -36.61131 10.06977  1.000 20.21859 ? 162 MET A CE   1 
ATOM   2421 H H    . MET A 1 162 ? -19.18805 -31.28631 12.11625  1.000 16.58290 ? 162 MET A H    1 
ATOM   2422 H HA   . MET A 1 162 ? -16.82289 -32.49107 11.54234  1.000 23.18982 ? 162 MET A HA   1 
ATOM   2423 H HB2  . MET A 1 162 ? -18.55406 -33.97659 11.09220  1.000 20.65502 ? 162 MET A HB2  1 
ATOM   2424 H HB3  . MET A 1 162 ? -19.20212 -32.91146 10.10697  1.000 20.65502 ? 162 MET A HB3  1 
ATOM   2425 H HG2  . MET A 1 162 ? -17.69508 -33.30060 8.50874   1.000 19.52797 ? 162 MET A HG2  1 
ATOM   2426 H HG3  . MET A 1 162 ? -16.62429 -33.86933 9.53608   1.000 19.52797 ? 162 MET A HG3  1 
ATOM   2427 H HE1  . MET A 1 162 ? -17.43023 -37.53455 9.90707   1.000 24.26231 ? 162 MET A HE1  1 
ATOM   2428 H HE2  . MET A 1 162 ? -16.23094 -36.49347 9.92152   1.000 24.26231 ? 162 MET A HE2  1 
ATOM   2429 H HE3  . MET A 1 162 ? -17.40829 -36.36237 10.97954  1.000 24.26231 ? 162 MET A HE3  1 
ATOM   2430 N N    . HIS A 1 163 ? -16.17864 -30.80052 9.85561   1.000 22.43581 ? 163 HIS A N    1 
ATOM   2431 C CA   . HIS A 1 163 ? -15.80420 -29.70768 8.98541   1.000 20.10275 ? 163 HIS A CA   1 
ATOM   2432 C C    . HIS A 1 163 ? -16.20045 -30.01812 7.55708   1.000 16.80727 ? 163 HIS A C    1 
ATOM   2433 O O    . HIS A 1 163 ? -15.85742 -31.09554 7.06554   1.000 19.91528 ? 163 HIS A O    1 
ATOM   2434 C CB   . HIS A 1 163 ? -14.30238 -29.49751 9.01307   1.000 16.24859 ? 163 HIS A CB   1 
ATOM   2435 C CG   . HIS A 1 163 ? -13.89502 -28.33268 8.20593   1.000 17.91349 ? 163 HIS A CG   1 
ATOM   2436 N ND1  . HIS A 1 163 ? -14.49505 -27.11526 8.37347   1.000 20.98717 ? 163 HIS A ND1  1 
ATOM   2437 C CD2  . HIS A 1 163 ? -13.06275 -28.20537 7.14831   1.000 19.19023 ? 163 HIS A CD2  1 
ATOM   2438 C CE1  . HIS A 1 163 ? -13.99143 -26.25733 7.51418   1.000 17.46871 ? 163 HIS A CE1  1 
ATOM   2439 N NE2  . HIS A 1 163 ? -13.13465 -26.89918 6.74708   1.000 18.66943 ? 163 HIS A NE2  1 
ATOM   2440 H H    . HIS A 1 163 ? -15.51833 -31.29614 10.09453  1.000 26.92297 ? 163 HIS A H    1 
ATOM   2441 H HA   . HIS A 1 163 ? -16.25695 -28.90523 9.28975   1.000 24.12329 ? 163 HIS A HA   1 
ATOM   2442 H HB2  . HIS A 1 163 ? -14.01782 -29.34784 9.92826   1.000 19.49831 ? 163 HIS A HB2  1 
ATOM   2443 H HB3  . HIS A 1 163 ? -13.86363 -30.28493 8.65374   1.000 19.49831 ? 163 HIS A HB3  1 
ATOM   2444 H HD2  . HIS A 1 163 ? -12.54308 -28.87572 6.76807   1.000 23.02827 ? 163 HIS A HD2  1 
ATOM   2445 H HE1  . HIS A 1 163 ? -14.20313 -25.35347 7.45766   1.000 20.96245 ? 163 HIS A HE1  1 
ATOM   2446 H HE2  . HIS A 1 163 ? -12.69069 -26.55342 6.09745   1.000 22.40332 ? 163 HIS A HE2  1 
ATOM   2447 N N    . HIS A 1 164 ? -16.81298 -29.04818 6.86146   1.000 15.64972 ? 164 HIS A N    1 
ATOM   2448 C CA   . HIS A 1 164 ? -17.20931 -29.26163 5.46619   1.000 14.10086 ? 164 HIS A CA   1 
ATOM   2449 C C    . HIS A 1 164 ? -16.62880 -28.23059 4.51703   1.000 18.21839 ? 164 HIS A C    1 
ATOM   2450 O O    . HIS A 1 164 ? -16.18613 -28.58856 3.42397   1.000 23.21519 ? 164 HIS A O    1 
ATOM   2451 C CB   . HIS A 1 164 ? -18.74924 -29.26573 5.25364   1.000 14.71451 ? 164 HIS A CB   1 
ATOM   2452 C CG   . HIS A 1 164 ? -19.41843 -30.50157 5.75465   1.000 19.64133 ? 164 HIS A CG   1 
ATOM   2453 N ND1  . HIS A 1 164 ? -20.18451 -31.30169 4.94988   1.000 16.32940 ? 164 HIS A ND1  1 
ATOM   2454 C CD2  . HIS A 1 164 ? -19.49144 -31.04339 6.99529   1.000 12.64916 ? 164 HIS A CD2  1 
ATOM   2455 C CE1  . HIS A 1 164 ? -20.65995 -32.31550 5.65209   1.000 14.15762 ? 164 HIS A CE1  1 
ATOM   2456 N NE2  . HIS A 1 164 ? -20.25750 -32.17995 6.90032   1.000 15.83476 ? 164 HIS A NE2  1 
ATOM   2457 H H    . HIS A 1 164 ? -17.00571 -28.27052 7.17387   1.000 18.77967 ? 164 HIS A H    1 
ATOM   2458 H HA   . HIS A 1 164 ? -16.87853 -30.14724 5.24776   1.000 16.92103 ? 164 HIS A HA   1 
ATOM   2459 H HB2  . HIS A 1 164 ? -19.13201 -28.50932 5.72498   1.000 17.65741 ? 164 HIS A HB2  1 
ATOM   2460 H HB3  . HIS A 1 164 ? -18.93396 -29.19229 4.30362   1.000 17.65741 ? 164 HIS A HB3  1 
ATOM   2461 H HD1  . HIS A 1 164 ? -20.33332 -31.16529 4.11391   1.000 19.59528 ? 164 HIS A HD1  1 
ATOM   2462 H HD2  . HIS A 1 164 ? -19.09598 -30.70755 7.76763   1.000 15.17899 ? 164 HIS A HD2  1 
ATOM   2463 H HE1  . HIS A 1 164 ? -21.18828 -33.00671 5.32248   1.000 16.98915 ? 164 HIS A HE1  1 
ATOM   2464 N N    . MET A 1 165 ? -16.70094 -26.95285 4.85979   1.000 16.36385 ? 165 MET A N    1 
ATOM   2465 C CA   . MET A 1 165 ? -16.34140 -25.94097 3.89254   1.000 19.82855 ? 165 MET A CA   1 
ATOM   2466 C C    . MET A 1 165 ? -15.66859 -24.71280 4.48154   1.000 21.44739 ? 165 MET A C    1 
ATOM   2467 O O    . MET A 1 165 ? -15.91329 -24.33871 5.64068   1.000 17.20325 ? 165 MET A O    1 
ATOM   2468 C CB   . MET A 1 165 ? -17.54455 -25.39043 3.08046   1.000 21.17847 ? 165 MET A CB   1 
ATOM   2469 C CG   . MET A 1 165 ? -18.74082 -26.22926 2.88952   1.000 36.46489 ? 165 MET A CG   1 
ATOM   2470 S SD   . MET A 1 165 ? -18.49461 -27.01907 1.26312   1.000 48.95966 ? 165 MET A SD   1 
ATOM   2471 C CE   . MET A 1 165 ? -18.86840 -25.56971 0.20988   1.000 40.63640 ? 165 MET A CE   1 
ATOM   2472 H H    . MET A 1 165 ? -16.94944 -26.65953 5.62889   1.000 19.63662 ? 165 MET A H    1 
ATOM   2473 H HA   . MET A 1 165 ? -15.71282 -26.41512 3.32547   1.000 23.79426 ? 165 MET A HA   1 
ATOM   2474 H HB2  . MET A 1 165 ? -17.84835 -24.58394 3.52485   1.000 25.41416 ? 165 MET A HB2  1 
ATOM   2475 H HB3  . MET A 1 165 ? -17.21941 -25.17662 2.19170   1.000 25.41416 ? 165 MET A HB3  1 
ATOM   2476 H HG2  . MET A 1 165 ? -18.80353 -26.90474 3.58208   1.000 43.75787 ? 165 MET A HG2  1 
ATOM   2477 H HG3  . MET A 1 165 ? -19.54525 -25.68790 2.87857   1.000 43.75787 ? 165 MET A HG3  1 
ATOM   2478 H HE1  . MET A 1 165 ? -18.78086 -25.82507 -0.72125  1.000 48.76368 ? 165 MET A HE1  1 
ATOM   2479 H HE2  . MET A 1 165 ? -19.77469 -25.27454 0.38874   1.000 48.76368 ? 165 MET A HE2  1 
ATOM   2480 H HE3  . MET A 1 165 ? -18.24204 -24.85934 0.41854   1.000 48.76368 ? 165 MET A HE3  1 
ATOM   2481 N N    . GLU A 1 166 ? -14.81178 -24.09360 3.64122   1.000 18.62438 ? 166 GLU A N    1 
ATOM   2482 C CA   . GLU A 1 166 ? -14.29094 -22.75534 3.89323   1.000 18.11425 ? 166 GLU A CA   1 
ATOM   2483 C C    . GLU A 1 166 ? -15.08142 -21.76643 3.02656   1.000 20.81354 ? 166 GLU A C    1 
ATOM   2484 O O    . GLU A 1 166 ? -15.17185 -21.93575 1.80643   1.000 21.89287 ? 166 GLU A O    1 
ATOM   2485 C CB   . GLU A 1 166 ? -12.79093 -22.63296 3.60384   1.000 18.60897 ? 166 GLU A CB   1 
ATOM   2486 C CG   . GLU A 1 166 ? -12.26020 -21.21379 4.00390   1.000 28.13212 ? 166 GLU A CG   1 
ATOM   2487 C CD   . GLU A 1 166 ? -10.72436 -21.06865 4.13653   1.000 40.79812 ? 166 GLU A CD   1 
ATOM   2488 O OE1  . GLU A 1 166 ? -10.08498 -21.86458 4.85426   1.000 36.13174 ? 166 GLU A OE1  1 
ATOM   2489 O OE2  . GLU A 1 166 ? -10.16495 -20.08486 3.58433   1.000 50.01676 ? 166 GLU A OE2  1 
ATOM   2490 H H    . GLU A 1 166 ? -14.52025 -24.44392 2.91111   1.000 22.34926 ? 166 GLU A H    1 
ATOM   2491 H HA   . GLU A 1 166 ? -14.40544 -22.54201 4.83232   1.000 21.73710 ? 166 GLU A HA   1 
ATOM   2492 H HB2  . GLU A 1 166 ? -12.30758 -23.29990 4.11660   1.000 22.33077 ? 166 GLU A HB2  1 
ATOM   2493 H HB3  . GLU A 1 166 ? -12.63349 -22.76525 2.65581   1.000 22.33077 ? 166 GLU A HB3  1 
ATOM   2494 H HG2  . GLU A 1 166 ? -12.54847 -20.58060 3.32819   1.000 33.75854 ? 166 GLU A HG2  1 
ATOM   2495 H HG3  . GLU A 1 166 ? -12.64369 -20.97862 4.86291   1.000 33.75854 ? 166 GLU A HG3  1 
ATOM   2496 N N    . LEU A 1 167 ? -15.68444 -20.75930 3.65597   1.000 23.16078 ? 167 LEU A N    1 
ATOM   2497 C CA   . LEU A 1 167 ? -16.34002 -19.70436 2.90339   1.000 26.79890 ? 167 LEU A CA   1 
ATOM   2498 C C    . LEU A 1 167 ? -15.30652 -18.78213 2.25632   1.000 28.33108 ? 167 LEU A C    1 
ATOM   2499 O O    . LEU A 1 167 ? -14.17275 -18.70351 2.71477   1.000 23.24497 ? 167 LEU A O    1 
ATOM   2500 C CB   . LEU A 1 167 ? -17.21400 -18.87862 3.82959   1.000 25.33745 ? 167 LEU A CB   1 
ATOM   2501 C CG   . LEU A 1 167 ? -18.27567 -19.64595 4.61474   1.000 24.02048 ? 167 LEU A CG   1 
ATOM   2502 C CD1  . LEU A 1 167 ? -19.13972 -18.64609 5.34605   1.000 31.37469 ? 167 LEU A CD1  1 
ATOM   2503 C CD2  . LEU A 1 167 ? -19.11168 -20.47605 3.69694   1.000 26.08036 ? 167 LEU A CD2  1 
ATOM   2504 H H    . LEU A 1 167 ? -15.72482 -20.66786 4.51001   1.000 27.79294 ? 167 LEU A H    1 
ATOM   2505 H HA   . LEU A 1 167 ? -16.88746 -20.09936 2.20695   1.000 32.15869 ? 167 LEU A HA   1 
ATOM   2506 H HB2  . LEU A 1 167 ? -16.63958 -18.44156 4.47706   1.000 30.40494 ? 167 LEU A HB2  1 
ATOM   2507 H HB3  . LEU A 1 167 ? -17.67734 -18.21466 3.29584   1.000 30.40494 ? 167 LEU A HB3  1 
ATOM   2508 H HG   . LEU A 1 167 ? -17.85441 -20.24701 5.24952   1.000 28.82457 ? 167 LEU A HG   1 
ATOM   2509 H HD11 . LEU A 1 167 ? -19.48168 -19.05686 6.15568   1.000 37.64962 ? 167 LEU A HD11 1 
ATOM   2510 H HD12 . LEU A 1 167 ? -18.60342 -17.86980 5.57072   1.000 37.64962 ? 167 LEU A HD12 1 
ATOM   2511 H HD13 . LEU A 1 167 ? -19.87573 -18.38432 4.77196   1.000 37.64962 ? 167 LEU A HD13 1 
ATOM   2512 H HD21 . LEU A 1 167 ? -19.93665 -20.71399 4.14950   1.000 31.29643 ? 167 LEU A HD21 1 
ATOM   2513 H HD22 . LEU A 1 167 ? -19.30981 -19.96272 2.89818   1.000 31.29643 ? 167 LEU A HD22 1 
ATOM   2514 H HD23 . LEU A 1 167 ? -18.62096 -21.27852 3.46061   1.000 31.29643 ? 167 LEU A HD23 1 
ATOM   2515 N N    . PRO A 1 168 ? -15.69174 -18.04079 1.20364   1.000 25.17740 ? 168 PRO A N    1 
ATOM   2516 C CA   . PRO A 1 168 ? -14.74229 -17.08566 0.60057   1.000 30.36237 ? 168 PRO A CA   1 
ATOM   2517 C C    . PRO A 1 168 ? -14.16641 -16.12284 1.62436   1.000 28.00488 ? 168 PRO A C    1 
ATOM   2518 O O    . PRO A 1 168 ? -13.02274 -15.64984 1.47806   1.000 31.37551 ? 168 PRO A O    1 
ATOM   2519 C CB   . PRO A 1 168 ? -15.58451 -16.34570 -0.43427  1.000 34.21690 ? 168 PRO A CB   1 
ATOM   2520 C CG   . PRO A 1 168 ? -16.65160 -17.31631 -0.81825  1.000 26.45399 ? 168 PRO A CG   1 
ATOM   2521 C CD   . PRO A 1 168 ? -16.85424 -18.28919 0.34108   1.000 29.41206 ? 168 PRO A CD   1 
ATOM   2522 H HA   . PRO A 1 168 ? -14.03274 -17.56382 0.14452   1.000 36.43484 ? 168 PRO A HA   1 
ATOM   2523 H HB2  . PRO A 1 168 ? -15.96629 -15.54524 -0.03992  1.000 41.06028 ? 168 PRO A HB2  1 
ATOM   2524 H HB3  . PRO A 1 168 ? -15.03743 -16.10879 -1.19994  1.000 41.06028 ? 168 PRO A HB3  1 
ATOM   2525 H HG2  . PRO A 1 168 ? -17.47293 -16.83085 -0.99524  1.000 31.74479 ? 168 PRO A HG2  1 
ATOM   2526 H HG3  . PRO A 1 168 ? -16.37194 -17.79660 -1.61345  1.000 31.74479 ? 168 PRO A HG3  1 
ATOM   2527 H HD2  . PRO A 1 168 ? -17.68056 -18.09713 0.81091   1.000 35.29448 ? 168 PRO A HD2  1 
ATOM   2528 H HD3  . PRO A 1 168 ? -16.85840 -19.20600 0.02451   1.000 35.29448 ? 168 PRO A HD3  1 
ATOM   2529 N N    . THR A 1 169 ? -14.93303 -15.81009 2.66229   1.000 31.53134 ? 169 THR A N    1 
ATOM   2530 C CA   . THR A 1 169 ? -14.48410 -14.95040 3.75198   1.000 29.49556 ? 169 THR A CA   1 
ATOM   2531 C C    . THR A 1 169 ? -13.40289 -15.58907 4.60996   1.000 25.89604 ? 169 THR A C    1 
ATOM   2532 O O    . THR A 1 169 ? -12.83974 -14.92016 5.48757   1.000 37.70716 ? 169 THR A O    1 
ATOM   2533 C CB   . THR A 1 169 ? -15.67769 -14.60390 4.63677   1.000 33.67219 ? 169 THR A CB   1 
ATOM   2534 O OG1  . THR A 1 169 ? -16.31388 -15.81167 5.07080   1.000 32.46263 ? 169 THR A OG1  1 
ATOM   2535 C CG2  . THR A 1 169 ? -16.69705 -13.79321 3.82791   1.000 38.36695 ? 169 THR A CG2  1 
ATOM   2536 H H    . THR A 1 169 ? -15.73984 -16.09079 2.76283   1.000 37.83761 ? 169 THR A H    1 
ATOM   2537 H HA   . THR A 1 169 ? -14.11762 -14.13488 3.37561   1.000 35.39468 ? 169 THR A HA   1 
ATOM   2538 H HB   . THR A 1 169 ? -15.38137 -14.08813 5.40319   1.000 40.40662 ? 169 THR A HB   1 
ATOM   2539 H HG1  . THR A 1 169 ? -16.92122 -15.63449 5.62369   1.000 38.95516 ? 169 THR A HG1  1 
ATOM   2540 H HG21 . THR A 1 169 ? -17.15076 -13.15992 4.40514   1.000 46.04033 ? 169 THR A HG21 1 
ATOM   2541 H HG22 . THR A 1 169 ? -16.24718 -13.30741 3.11937   1.000 46.04033 ? 169 THR A HG22 1 
ATOM   2542 H HG23 . THR A 1 169 ? -17.35544 -14.38749 3.43331   1.000 46.04033 ? 169 THR A HG23 1 
ATOM   2543 N N    . GLY A 1 170 ? -13.11581 -16.86572 4.41728   1.000 24.80128 ? 170 GLY A N    1 
ATOM   2544 C CA   . GLY A 1 170 ? -12.07757 -17.50437 5.18825   1.000 31.17799 ? 170 GLY A CA   1 
ATOM   2545 C C    . GLY A 1 170 ? -12.53655 -18.11353 6.48371   1.000 22.91380 ? 170 GLY A C    1 
ATOM   2546 O O    . GLY A 1 170 ? -11.70637 -18.66333 7.22167   1.000 34.13172 ? 170 GLY A O    1 
ATOM   2547 H H    . GLY A 1 170 ? -13.50920 -17.37668 3.84882   1.000 29.76153 ? 170 GLY A H    1 
ATOM   2548 H HA2  . GLY A 1 170 ? -11.68282 -18.21073 4.65295   1.000 37.41359 ? 170 GLY A HA2  1 
ATOM   2549 H HA3  . GLY A 1 170 ? -11.39517 -16.84695 5.39590   1.000 37.41359 ? 170 GLY A HA3  1 
ATOM   2550 N N    . VAL A 1 171 ? -13.82670 -18.05975 6.79329   1.000 29.95238 ? 171 VAL A N    1 
ATOM   2551 C CA   . VAL A 1 171 ? -14.31758 -18.74388 7.98970   1.000 31.42167 ? 171 VAL A CA   1 
ATOM   2552 C C    . VAL A 1 171 ? -14.84834 -20.11506 7.58866   1.000 18.98472 ? 171 VAL A C    1 
ATOM   2553 O O    . VAL A 1 171 ? -15.03270 -20.40047 6.40242   1.000 19.79902 ? 171 VAL A O    1 
ATOM   2554 C CB   . VAL A 1 171 ? -15.39050 -17.92120 8.73783   1.000 27.34842 ? 171 VAL A CB   1 
ATOM   2555 C CG1  . VAL A 1 171 ? -14.93059 -16.49903 8.94609   1.000 38.87569 ? 171 VAL A CG1  1 
ATOM   2556 C CG2  . VAL A 1 171 ? -16.67216 -17.88350 7.93127   1.000 27.96727 ? 171 VAL A CG2  1 
ATOM   2557 H H    . VAL A 1 171 ? -14.42587 -17.64295 6.33934   1.000 35.94286 ? 171 VAL A H    1 
ATOM   2558 H HA   . VAL A 1 171 ? -13.57570 -18.86467 8.60188   1.000 37.70600 ? 171 VAL A HA   1 
ATOM   2559 H HB   . VAL A 1 171 ? -15.54459 -18.34295 9.59744   1.000 32.81810 ? 171 VAL A HB   1 
ATOM   2560 H HG11 . VAL A 1 171 ? -15.62300 -16.00953 9.41679   1.000 46.65083 ? 171 VAL A HG11 1 
ATOM   2561 H HG12 . VAL A 1 171 ? -14.11482 -16.50461 9.47060   1.000 46.65083 ? 171 VAL A HG12 1 
ATOM   2562 H HG13 . VAL A 1 171 ? -14.76561 -16.09085 8.08172   1.000 46.65083 ? 171 VAL A HG13 1 
ATOM   2563 H HG21 . VAL A 1 171 ? -17.33355 -17.36357 8.41400   1.000 33.56073 ? 171 VAL A HG21 1 
ATOM   2564 H HG22 . VAL A 1 171 ? -16.49131 -17.47131 7.07101   1.000 33.56073 ? 171 VAL A HG22 1 
ATOM   2565 H HG23 . VAL A 1 171 ? -16.99172 -18.78946 7.80397   1.000 33.56073 ? 171 VAL A HG23 1 
ATOM   2566 N N    . HIS A 1 172 ? -15.07702 -20.96385 8.57106   1.000 17.59161 ? 172 HIS A N    1 
ATOM   2567 C CA   . HIS A 1 172 ? -15.30582 -22.38692 8.38810   1.000 16.92807 ? 172 HIS A CA   1 
ATOM   2568 C C    . HIS A 1 172 ? -16.70570 -22.74531 8.84739   1.000 18.02461 ? 172 HIS A C    1 
ATOM   2569 O O    . HIS A 1 172 ? -17.21548 -22.19232 9.82955   1.000 20.22932 ? 172 HIS A O    1 
ATOM   2570 C CB   . HIS A 1 172 ? -14.21347 -23.16551 9.14301   1.000 18.52286 ? 172 HIS A CB   1 
ATOM   2571 C CG   . HIS A 1 172 ? -12.83962 -22.77114 8.68573   1.000 21.34830 ? 172 HIS A CG   1 
ATOM   2572 N ND1  . HIS A 1 172 ? -11.89938 -22.18390 9.51943   1.000 22.84774 ? 172 HIS A ND1  1 
ATOM   2573 C CD2  . HIS A 1 172 ? -12.27214 -22.82493 7.45590   1.000 20.97240 ? 172 HIS A CD2  1 
ATOM   2574 C CE1  . HIS A 1 172 ? -10.80434 -21.92060 8.82098   1.000 26.33661 ? 172 HIS A CE1  1 
ATOM   2575 N NE2  . HIS A 1 172 ? -11.01060 -22.29099 7.56868   1.000 26.04049 ? 172 HIS A NE2  1 
ATOM   2576 H H    . HIS A 1 172 ? -15.10549 -20.72938 9.39719   1.000 21.10993 ? 172 HIS A H    1 
ATOM   2577 H HA   . HIS A 1 172 ? -15.26628 -22.64531 7.45396   1.000 20.31369 ? 172 HIS A HA   1 
ATOM   2578 H HB2  . HIS A 1 172 ? -14.28495 -22.97915 10.09210  1.000 22.22743 ? 172 HIS A HB2  1 
ATOM   2579 H HB3  . HIS A 1 172 ? -14.32765 -24.11550 8.98238   1.000 22.22743 ? 172 HIS A HB3  1 
ATOM   2580 H HD2  . HIS A 1 172 ? -12.66260 -23.16076 6.68056   1.000 25.16688 ? 172 HIS A HD2  1 
ATOM   2581 H HE1  . HIS A 1 172 ? -10.02376 -21.54018 9.15449   1.000 31.60394 ? 172 HIS A HE1  1 
ATOM   2582 H HE2  . HIS A 1 172 ? -10.44444 -22.21014 6.92593   1.000 31.24858 ? 172 HIS A HE2  1 
ATOM   2583 N N    . VAL A 1 173 ? -17.30069 -23.68134 8.11860   1.000 17.02694 ? 173 VAL A N    1 
ATOM   2584 C CA   . VAL A 1 173 ? -18.64941 -24.14456 8.36384   1.000 15.90029 ? 173 VAL A CA   1 
ATOM   2585 C C    . VAL A 1 173 ? -18.71115 -25.65952 8.20488   1.000 13.36441 ? 173 VAL A C    1 
ATOM   2586 O O    . VAL A 1 173 ? -17.88942 -26.27844 7.52179   1.000 17.57677 ? 173 VAL A O    1 
ATOM   2587 C CB   . VAL A 1 173 ? -19.66965 -23.44381 7.45291   1.000 15.18077 ? 173 VAL A CB   1 
ATOM   2588 C CG1  . VAL A 1 173 ? -19.68695 -21.91298 7.70185   1.000 18.09309 ? 173 VAL A CG1  1 
ATOM   2589 C CG2  . VAL A 1 173 ? -19.50681 -23.81975 5.93673   1.000 17.49622 ? 173 VAL A CG2  1 
ATOM   2590 H H    . VAL A 1 173 ? -16.92414 -24.07563 7.45249   1.000 20.43233 ? 173 VAL A H    1 
ATOM   2591 H HA   . VAL A 1 173 ? -18.88289 -23.94732 9.28388   1.000 19.08035 ? 173 VAL A HA   1 
ATOM   2592 N N    . GLY A 1 174 ? -19.71990 -26.25270 8.82616   1.000 13.24888 ? 174 GLY A N    1 
ATOM   2593 C CA   . GLY A 1 174 ? -19.78478 -27.69681 8.91925   1.000 13.57391 ? 174 GLY A CA   1 
ATOM   2594 C C    . GLY A 1 174 ? -21.07370 -28.09925 9.58254   1.000 15.62773 ? 174 GLY A C    1 
ATOM   2595 O O    . GLY A 1 174 ? -21.94446 -27.25511 9.85476   1.000 13.74311 ? 174 GLY A O    1 
ATOM   2596 H H    . GLY A 1 174 ? -20.37636 -25.84145 9.20018   1.000 15.89866 ? 174 GLY A H    1 
ATOM   2597 H HA2  . GLY A 1 174 ? -19.74816 -28.08924 8.03302   1.000 16.28870 ? 174 GLY A HA2  1 
ATOM   2598 H HA3  . GLY A 1 174 ? -19.04070 -28.03054 9.44330   1.000 16.28870 ? 174 GLY A HA3  1 
ATOM   2599 N N    . THR A 1 175 ? -21.14480 -29.37451 9.91873   1.000 15.17582 ? 175 THR A N    1 
ATOM   2600 C CA   . THR A 1 175 ? -22.37046 -30.00577 10.37791  1.000 18.86962 ? 175 THR A CA   1 
ATOM   2601 C C    . THR A 1 175 ? -22.18544 -30.64047 11.75659  1.000 17.36249 ? 175 THR A C    1 
ATOM   2602 O O    . THR A 1 175 ? -21.07453 -30.76292 12.29590  1.000 18.03521 ? 175 THR A O    1 
ATOM   2603 C CB   . THR A 1 175 ? -22.81424 -31.09150 9.37008   1.000 13.10416 ? 175 THR A CB   1 
ATOM   2604 O OG1  . THR A 1 175 ? -21.88937 -32.17877 9.37174   1.000 16.55444 ? 175 THR A OG1  1 
ATOM   2605 C CG2  . THR A 1 175 ? -23.00523 -30.48980 7.98039   1.000 17.68865 ? 175 THR A CG2  1 
ATOM   2606 H H    . THR A 1 175 ? -20.47436 -29.91296 9.88764   1.000 18.21098 ? 175 THR A H    1 
ATOM   2607 H HA   . THR A 1 175 ? -23.05703 -29.32637 10.46009  1.000 22.64354 ? 175 THR A HA   1 
ATOM   2608 H HB   . THR A 1 175 ? -23.67504 -31.45535 9.63056   1.000 15.72499 ? 175 THR A HB   1 
ATOM   2609 H HG1  . THR A 1 175 ? -22.00823 -32.65728 10.05240  1.000 19.86533 ? 175 THR A HG1  1 
ATOM   2610 H HG21 . THR A 1 175 ? -23.41050 -31.14276 7.38884   1.000 21.22638 ? 175 THR A HG21 1 
ATOM   2611 H HG22 . THR A 1 175 ? -23.58187 -29.71129 8.03266   1.000 21.22638 ? 175 THR A HG22 1 
ATOM   2612 H HG23 . THR A 1 175 ? -22.14831 -30.22189 7.61386   1.000 21.22638 ? 175 THR A HG23 1 
ATOM   2613 N N    . ASP A 1 176 ? -23.30636 -31.00774 12.36096  1.000 18.23384 ? 176 ASP A N    1 
ATOM   2614 C CA   . ASP A 1 176 ? -23.28295 -32.00138 13.43136  1.000 17.96409 ? 176 ASP A CA   1 
ATOM   2615 C C    . ASP A 1 176 ? -23.06462 -33.37580 12.77159  1.000 20.04434 ? 176 ASP A C    1 
ATOM   2616 O O    . ASP A 1 176 ? -22.84410 -33.48787 11.55260  1.000 17.37921 ? 176 ASP A O    1 
ATOM   2617 C CB   . ASP A 1 176 ? -24.54437 -31.86192 14.29600  1.000 19.63210 ? 176 ASP A CB   1 
ATOM   2618 C CG   . ASP A 1 176 ? -25.80482 -32.22948 13.57433  1.000 22.90685 ? 176 ASP A CG   1 
ATOM   2619 O OD1  . ASP A 1 176 ? -25.73488 -32.98183 12.60889  1.000 21.83897 ? 176 ASP A OD1  1 
ATOM   2620 O OD2  . ASP A 1 176 ? -26.90331 -31.82765 14.06119  1.000 26.50770 ? 176 ASP A OD2  1 
ATOM   2621 H H    . ASP A 1 176 ? -24.08754 -30.70024 12.17288  1.000 21.88061 ? 176 ASP A H    1 
ATOM   2622 H HA   . ASP A 1 176 ? -22.54128 -31.85516 14.03871  1.000 21.55691 ? 176 ASP A HA   1 
ATOM   2623 H HB2  . ASP A 1 176 ? -24.46218 -32.44633 15.06667  1.000 23.55852 ? 176 ASP A HB2  1 
ATOM   2624 H HB3  . ASP A 1 176 ? -24.62620 -30.94016 14.58554  1.000 23.55852 ? 176 ASP A HB3  1 
ATOM   2625 N N    . LEU A 1 177 ? -23.02707 -34.42826 13.56395  1.000 15.53457 ? 177 LEU A N    1 
ATOM   2626 C CA   . LEU A 1 177 ? -22.69083 -35.75268 13.05926  1.000 18.84222 ? 177 LEU A CA   1 
ATOM   2627 C C    . LEU A 1 177 ? -23.89906 -36.47630 12.50438  1.000 20.76031 ? 177 LEU A C    1 
ATOM   2628 O O    . LEU A 1 177 ? -23.77500 -37.64196 12.11471  1.000 26.57856 ? 177 LEU A O    1 
ATOM   2629 C CB   . LEU A 1 177 ? -22.07652 -36.62086 14.13694  1.000 21.48354 ? 177 LEU A CB   1 
ATOM   2630 C CG   . LEU A 1 177 ? -20.57668 -36.48375 14.27455  1.000 24.26082 ? 177 LEU A CG   1 
ATOM   2631 C CD1  . LEU A 1 177 ? -19.86770 -37.20347 13.11136  1.000 19.32561 ? 177 LEU A CD1  1 
ATOM   2632 C CD2  . LEU A 1 177 ? -20.07181 -35.05834 14.26561  1.000 21.43451 ? 177 LEU A CD2  1 
ATOM   2633 H H    . LEU A 1 177 ? -23.19338 -34.40591 14.40691  1.000 18.64148 ? 177 LEU A H    1 
ATOM   2634 H HA   . LEU A 1 177 ? -22.02668 -35.63972 12.36156  1.000 22.61066 ? 177 LEU A HA   1 
ATOM   2635 H HB2  . LEU A 1 177 ? -22.47202 -36.37970 14.98895  1.000 25.78024 ? 177 LEU A HB2  1 
ATOM   2636 H HB3  . LEU A 1 177 ? -22.26871 -37.54888 13.93230  1.000 25.78024 ? 177 LEU A HB3  1 
ATOM   2637 H HG   . LEU A 1 177 ? -20.36667 -36.87411 15.13738  1.000 29.11298 ? 177 LEU A HG   1 
ATOM   2638 H HD11 . LEU A 1 177 ? -18.92470 -37.29185 13.32264  1.000 23.19073 ? 177 LEU A HD11 1 
ATOM   2639 H HD12 . LEU A 1 177 ? -20.26296 -38.08071 12.99468  1.000 23.19073 ? 177 LEU A HD12 1 
ATOM   2640 H HD13 . LEU A 1 177 ? -19.97783 -36.68005 12.30264  1.000 23.19073 ? 177 LEU A HD13 1 
ATOM   2641 H HD21 . LEU A 1 177 ? -19.10584 -35.06563 14.36094  1.000 25.72141 ? 177 LEU A HD21 1 
ATOM   2642 H HD22 . LEU A 1 177 ? -20.31885 -34.64102 13.42578  1.000 25.72141 ? 177 LEU A HD22 1 
ATOM   2643 H HD23 . LEU A 1 177 ? -20.47346 -34.57711 15.00576  1.000 25.72141 ? 177 LEU A HD23 1 
ATOM   2644 N N    . GLU A 1 178 ? -25.06759 -35.83726 12.55436  1.000 18.64998 ? 178 GLU A N    1 
ATOM   2645 C CA   . GLU A 1 178 ? -26.20596 -36.27769 11.77869  1.000 26.06496 ? 178 GLU A CA   1 
ATOM   2646 C C    . GLU A 1 178 ? -26.25906 -35.56091 10.43711  1.000 18.84209 ? 178 GLU A C    1 
ATOM   2647 O O    . GLU A 1 178 ? -27.20964 -35.74619 9.66366   1.000 23.24954 ? 178 GLU A O    1 
ATOM   2648 C CB   . GLU A 1 178 ? -27.50743 -36.01819 12.52439  1.000 21.37087 ? 178 GLU A CB   1 
ATOM   2649 C CG   . GLU A 1 178 ? -27.62114 -36.92001 13.71980  1.000 21.82663 ? 178 GLU A CG   1 
ATOM   2650 C CD   . GLU A 1 178 ? -28.99543 -36.84050 14.35836  1.000 42.55270 ? 178 GLU A CD   1 
ATOM   2651 O OE1  . GLU A 1 178 ? -29.57034 -35.73902 14.45984  1.000 41.70653 ? 178 GLU A OE1  1 
ATOM   2652 O OE2  . GLU A 1 178 ? -29.42379 -37.88218 14.90757  1.000 41.32857 ? 178 GLU A OE2  1 
ATOM   2653 H H    . GLU A 1 178 ? -25.21831 -35.14068 13.03574  1.000 22.37998 ? 178 GLU A H    1 
ATOM   2654 H HA   . GLU A 1 178 ? -26.14115 -37.23555 11.64112  1.000 31.27795 ? 178 GLU A HA   1 
ATOM   2655 H HB2  . GLU A 1 178 ? -27.52927 -35.09739 12.82795  1.000 25.64505 ? 178 GLU A HB2  1 
ATOM   2656 H HB3  . GLU A 1 178 ? -28.25809 -36.19042 11.93502  1.000 25.64505 ? 178 GLU A HB3  1 
ATOM   2657 H HG2  . GLU A 1 178 ? -27.46631 -37.83672 13.44429  1.000 26.19196 ? 178 GLU A HG2  1 
ATOM   2658 H HG3  . GLU A 1 178 ? -26.96258 -36.65690 14.38219  1.000 26.19196 ? 178 GLU A HG3  1 
ATOM   2659 N N    . GLY A 1 179 ? -25.28064 -34.69995 10.14699  1.000 19.82207 ? 179 GLY A N    1 
ATOM   2660 C CA   . GLY A 1 179 ? -25.17767 -34.08005 8.82841   1.000 16.19217 ? 179 GLY A CA   1 
ATOM   2661 C C    . GLY A 1 179 ? -25.95362 -32.80155 8.63092   1.000 16.34800 ? 179 GLY A C    1 
ATOM   2662 O O    . GLY A 1 179 ? -26.06258 -32.33793 7.48917   1.000 18.35861 ? 179 GLY A O    1 
ATOM   2663 H H    . GLY A 1 179 ? -24.66603 -34.45980 10.69835  1.000 23.78649 ? 179 GLY A H    1 
ATOM   2664 H HA2  . GLY A 1 179 ? -24.24377 -33.88120 8.65686   1.000 19.43061 ? 179 GLY A HA2  1 
ATOM   2665 H HA3  . GLY A 1 179 ? -25.49293 -34.71490 8.16691   1.000 19.43061 ? 179 GLY A HA3  1 
ATOM   2666 N N    . ASN A 1 180 ? -26.49646 -32.21163 9.69109   1.000 17.93582 ? 180 ASN A N    1 
ATOM   2667 C CA   . ASN A 1 180 ? -27.19943 -30.95313 9.58862   1.000 16.02898 ? 180 ASN A CA   1 
ATOM   2668 C C    . ASN A 1 180 ? -26.22141 -29.81147 9.78867   1.000 15.06803 ? 180 ASN A C    1 
ATOM   2669 O O    . ASN A 1 180 ? -25.55984 -29.73759 10.83195  1.000 19.92625 ? 180 ASN A O    1 
ATOM   2670 C CB   . ASN A 1 180 ? -28.32085 -30.88566 10.62527  1.000 16.04061 ? 180 ASN A CB   1 
ATOM   2671 C CG   . ASN A 1 180 ? -29.27590 -32.04437 10.53622  1.000 25.39769 ? 180 ASN A CG   1 
ATOM   2672 O OD1  . ASN A 1 180 ? -29.98042 -32.19831 9.53687   1.000 29.64476 ? 180 ASN A OD1  1 
ATOM   2673 N ND2  . ASN A 1 180 ? -29.30360 -32.87002 11.56470  1.000 31.89626 ? 180 ASN A ND2  1 
ATOM   2674 H H    . ASN A 1 180 ? -26.46749 -32.53110 10.48891  1.000 21.52298 ? 180 ASN A H    1 
ATOM   2675 H HA   . ASN A 1 180 ? -27.58918 -30.86989 8.70454   1.000 19.23478 ? 180 ASN A HA   1 
ATOM   2676 H HB2  . ASN A 1 180 ? -27.92916 -30.88890 11.51341  1.000 19.24873 ? 180 ASN A HB2  1 
ATOM   2677 H HB3  . ASN A 1 180 ? -28.82745 -30.06998 10.48959  1.000 19.24873 ? 180 ASN A HB3  1 
ATOM   2678 H HD21 . ASN A 1 180 ? -29.83406 -33.54744 11.55909  1.000 38.27551 ? 180 ASN A HD21 1 
ATOM   2679 H HD22 . ASN A 1 180 ? -28.79095 -32.73203 12.24196  1.000 38.27551 ? 180 ASN A HD22 1 
ATOM   2680 N N    . PHE A 1 181 ? -26.11676 -28.93478 8.79725   1.000 17.77536 ? 181 PHE A N    1 
ATOM   2681 C CA   . PHE A 1 181 ? -25.26975 -27.76221 8.97027   1.000 17.07103 ? 181 PHE A CA   1 
ATOM   2682 C C    . PHE A 1 181 ? -25.64381 -26.98928 10.21762  1.000 20.81134 ? 181 PHE A C    1 
ATOM   2683 O O    . PHE A 1 181 ? -26.82105 -26.83443 10.56830  1.000 19.68833 ? 181 PHE A O    1 
ATOM   2684 C CB   . PHE A 1 181 ? -25.32205 -26.83348 7.72682   1.000 17.64134 ? 181 PHE A CB   1 
ATOM   2685 C CG   . PHE A 1 181 ? -24.25145 -27.14402 6.73201   1.000 15.85741 ? 181 PHE A CG   1 
ATOM   2686 C CD1  . PHE A 1 181 ? -24.46534 -28.09657 5.72235   1.000 18.37501 ? 181 PHE A CD1  1 
ATOM   2687 C CD2  . PHE A 1 181 ? -23.01797 -26.52608 6.80083   1.000 17.77145 ? 181 PHE A CD2  1 
ATOM   2688 C CE1  . PHE A 1 181 ? -23.46077 -28.40320 4.80551   1.000 19.66929 ? 181 PHE A CE1  1 
ATOM   2689 C CE2  . PHE A 1 181 ? -22.01440 -26.83072 5.89099   1.000 16.06954 ? 181 PHE A CE2  1 
ATOM   2690 C CZ   . PHE A 1 181 ? -22.23729 -27.78229 4.90033   1.000 18.22794 ? 181 PHE A CZ   1 
ATOM   2691 H H    . PHE A 1 181 ? -26.51244 -28.99462 8.03607   1.000 21.33043 ? 181 PHE A H    1 
ATOM   2692 H HA   . PHE A 1 181 ? -24.35454 -28.06854 9.06841   1.000 20.48524 ? 181 PHE A HA   1 
ATOM   2693 H HB2  . PHE A 1 181 ? -26.18081 -26.94090 7.28846   1.000 21.16961 ? 181 PHE A HB2  1 
ATOM   2694 H HB3  . PHE A 1 181 ? -25.20888 -25.91457 8.01443   1.000 21.16961 ? 181 PHE A HB3  1 
ATOM   2695 H HD1  . PHE A 1 181 ? -25.28797 -28.52819 5.66379   1.000 22.05001 ? 181 PHE A HD1  1 
ATOM   2696 H HD2  . PHE A 1 181 ? -22.85670 -25.89636 7.46627   1.000 21.32574 ? 181 PHE A HD2  1 
ATOM   2697 H HE1  . PHE A 1 181 ? -23.61803 -29.02491 4.13207   1.000 23.60314 ? 181 PHE A HE1  1 
ATOM   2698 H HE2  . PHE A 1 181 ? -21.19176 -26.39910 5.94355   1.000 19.28344 ? 181 PHE A HE2  1 
ATOM   2699 H HZ   . PHE A 1 181 ? -21.55891 -27.99838 4.30243   1.000 21.87353 ? 181 PHE A HZ   1 
ATOM   2700 N N    . TYR A 1 182 ? -24.61744 -26.48786 10.87229  1.000 17.95891 ? 182 TYR A N    1 
ATOM   2701 C CA   . TYR A 1 182 ? -24.78764 -25.36654 11.75592  1.000 22.60025 ? 182 TYR A CA   1 
ATOM   2702 C C    . TYR A 1 182 ? -24.89135 -24.10911 10.92366  1.000 19.05510 ? 182 TYR A C    1 
ATOM   2703 O O    . TYR A 1 182 ? -23.99928 -23.83089 10.10114  1.000 20.78016 ? 182 TYR A O    1 
ATOM   2704 C CB   . TYR A 1 182 ? -23.61406 -25.25319 12.69840  1.000 23.01599 ? 182 TYR A CB   1 
ATOM   2705 C CG   . TYR A 1 182 ? -23.52158 -26.32576 13.74077  1.000 20.90424 ? 182 TYR A CG   1 
ATOM   2706 C CD1  . TYR A 1 182 ? -24.25108 -26.22807 14.92858  1.000 21.79365 ? 182 TYR A CD1  1 
ATOM   2707 C CD2  . TYR A 1 182 ? -22.68764 -27.41498 13.55340  1.000 18.17295 ? 182 TYR A CD2  1 
ATOM   2708 C CE1  . TYR A 1 182 ? -24.13866 -27.18758 15.90803  1.000 17.24898 ? 182 TYR A CE1  1 
ATOM   2709 C CE2  . TYR A 1 182 ? -22.55922 -28.37547 14.51785  1.000 14.09497 ? 182 TYR A CE2  1 
ATOM   2710 C CZ   . TYR A 1 182 ? -23.29972 -28.26679 15.69366  1.000 19.66774 ? 182 TYR A CZ   1 
ATOM   2711 O OH   . TYR A 1 182 ? -23.16830 -29.21926 16.63912  1.000 17.20508 ? 182 TYR A OH   1 
ATOM   2712 H H    . TYR A 1 182 ? -23.81118 -26.78319 10.82039  1.000 21.55070 ? 182 TYR A H    1 
ATOM   2713 H HA   . TYR A 1 182 ? -25.59174 -25.47851 12.28557  1.000 27.12030 ? 182 TYR A HA   1 
ATOM   2714 H HB2  . TYR A 1 182 ? -22.79785 -25.28722 12.17467  1.000 27.61919 ? 182 TYR A HB2  1 
ATOM   2715 H HB3  . TYR A 1 182 ? -23.67490 -24.40352 13.16191  1.000 27.61919 ? 182 TYR A HB3  1 
ATOM   2716 H HD1  . TYR A 1 182 ? -24.81970 -25.50460 15.05982  1.000 26.15238 ? 182 TYR A HD1  1 
ATOM   2717 H HD2  . TYR A 1 182 ? -22.20730 -27.49411 12.76152  1.000 21.80754 ? 182 TYR A HD2  1 
ATOM   2718 H HE1  . TYR A 1 182 ? -24.61900 -27.11146 16.70090  1.000 20.69878 ? 182 TYR A HE1  1 
ATOM   2719 H HE2  . TYR A 1 182 ? -21.98360 -29.09493 14.39061  1.000 16.91396 ? 182 TYR A HE2  1 
ATOM   2720 H HH   . TYR A 1 182 ? -22.50685 -29.70663 16.46505  1.000 20.64609 ? 182 TYR A HH   1 
ATOM   2721 N N    . GLY A 1 183 ? -25.95304 -23.33309 11.13676  1.000 19.63294 ? 183 GLY A N    1 
ATOM   2722 C CA   . GLY A 1 183 ? -26.16576 -22.10280 10.40144  1.000 16.55713 ? 183 GLY A CA   1 
ATOM   2723 C C    . GLY A 1 183 ? -26.86710 -22.34455 9.08005   1.000 17.94845 ? 183 GLY A C    1 
ATOM   2724 O O    . GLY A 1 183 ? -27.31511 -23.45972 8.78720   1.000 22.24553 ? 183 GLY A O    1 
ATOM   2725 H H    . GLY A 1 183 ? -26.56911 -23.50593 11.71144  1.000 23.55953 ? 183 GLY A H    1 
ATOM   2726 H HA2  . GLY A 1 183 ? -26.70943 -21.49956 10.93262  1.000 19.86856 ? 183 GLY A HA2  1 
ATOM   2727 H HA3  . GLY A 1 183 ? -25.31003 -21.68201 10.22301  1.000 19.86856 ? 183 GLY A HA3  1 
ATOM   2728 N N    . PRO A 1 184 ? -26.90663 -21.31007 8.25067   1.000 19.16215 ? 184 PRO A N    1 
ATOM   2729 C CA   . PRO A 1 184 ? -27.70317 -21.34194 7.01037   1.000 18.87310 ? 184 PRO A CA   1 
ATOM   2730 C C    . PRO A 1 184 ? -26.90034 -21.85357 5.82834   1.000 23.69018 ? 184 PRO A C    1 
ATOM   2731 O O    . PRO A 1 184 ? -27.23018 -21.54913 4.68341   1.000 26.95633 ? 184 PRO A O    1 
ATOM   2732 C CB   . PRO A 1 184 ? -28.05127 -19.86008 6.79916   1.000 23.36114 ? 184 PRO A CB   1 
ATOM   2733 C CG   . PRO A 1 184 ? -26.75497 -19.20335 7.28002   1.000 20.79294 ? 184 PRO A CG   1 
ATOM   2734 C CD   . PRO A 1 184 ? -26.37880 -19.95581 8.50969   1.000 25.23862 ? 184 PRO A CD   1 
ATOM   2735 H HA   . PRO A 1 184 ? -28.50479 -21.87365 7.13276   1.000 22.64773 ? 184 PRO A HA   1 
ATOM   2736 H HB2  . PRO A 1 184 ? -28.22909 -19.67365 5.86421   1.000 28.03336 ? 184 PRO A HB2  1 
ATOM   2737 H HB3  . PRO A 1 184 ? -28.81367 -19.60002 7.34005   1.000 28.03336 ? 184 PRO A HB3  1 
ATOM   2738 H HG2  . PRO A 1 184 ? -26.06866 -19.28638 6.59921   1.000 24.95153 ? 184 PRO A HG2  1 
ATOM   2739 H HG3  . PRO A 1 184 ? -26.91178 -18.26759 7.47955   1.000 24.95153 ? 184 PRO A HG3  1 
ATOM   2740 H HD2  . PRO A 1 184 ? -25.41582 -19.97611 8.62202   1.000 30.28634 ? 184 PRO A HD2  1 
ATOM   2741 H HD3  . PRO A 1 184 ? -26.79639 -19.56662 9.29379   1.000 30.28634 ? 184 PRO A HD3  1 
ATOM   2742 N N    . PHE A 1 185 ? -25.82185 -22.57485 6.05927   1.000 22.50086 ? 185 PHE A N    1 
ATOM   2743 C CA   . PHE A 1 185 ? -24.91720 -22.90146 4.96639   1.000 20.56334 ? 185 PHE A CA   1 
ATOM   2744 C C    . PHE A 1 185 ? -25.31792 -24.21437 4.29944   1.000 20.88363 ? 185 PHE A C    1 
ATOM   2745 O O    . PHE A 1 185 ? -26.02846 -25.05228 4.86867   1.000 20.05507 ? 185 PHE A O    1 
ATOM   2746 C CB   . PHE A 1 185 ? -23.47037 -22.92563 5.49489   1.000 19.17540 ? 185 PHE A CB   1 
ATOM   2747 C CG   . PHE A 1 185 ? -23.13263 -21.70086 6.30576   1.000 21.92514 ? 185 PHE A CG   1 
ATOM   2748 C CD1  . PHE A 1 185 ? -22.90037 -20.48929 5.67459   1.000 21.11273 ? 185 PHE A CD1  1 
ATOM   2749 C CD2  . PHE A 1 185 ? -23.09208 -21.74568 7.68175   1.000 21.97030 ? 185 PHE A CD2  1 
ATOM   2750 C CE1  . PHE A 1 185 ? -22.62655 -19.33651 6.39540   1.000 22.44463 ? 185 PHE A CE1  1 
ATOM   2751 C CE2  . PHE A 1 185 ? -22.81524 -20.61091 8.41255   1.000 16.26253 ? 185 PHE A CE2  1 
ATOM   2752 C CZ   . PHE A 1 185 ? -22.57898 -19.40934 7.79237   1.000 17.34600 ? 185 PHE A CZ   1 
ATOM   2753 H H    . PHE A 1 185 ? -25.59187 -22.88514 6.82816   1.000 27.00103 ? 185 PHE A H    1 
ATOM   2754 H HA   . PHE A 1 185 ? -24.96149 -22.22906 4.26979   1.000 24.67601 ? 185 PHE A HA   1 
ATOM   2755 H HB2  . PHE A 1 185 ? -23.35195 -23.70389 6.06145   1.000 23.01048 ? 185 PHE A HB2  1 
ATOM   2756 H HB3  . PHE A 1 185 ? -22.85907 -22.96668 4.74208   1.000 23.01048 ? 185 PHE A HB3  1 
ATOM   2757 H HD1  . PHE A 1 185 ? -22.92808 -20.44774 4.74661   1.000 25.33528 ? 185 PHE A HD1  1 
ATOM   2758 H HD2  . PHE A 1 185 ? -23.25260 -22.54908 8.12120   1.000 26.36436 ? 185 PHE A HD2  1 
ATOM   2759 H HE1  . PHE A 1 185 ? -22.47703 -18.53013 5.95795   1.000 26.93356 ? 185 PHE A HE1  1 
ATOM   2760 H HE2  . PHE A 1 185 ? -22.78853 -20.66046 9.34153   1.000 19.51504 ? 185 PHE A HE2  1 
ATOM   2761 H HZ   . PHE A 1 185 ? -22.38976 -18.65050 8.29591   1.000 20.81520 ? 185 PHE A HZ   1 
ATOM   2762 N N    . VAL A 1 186 ? -24.88237 -24.35124 3.03551   1.000 26.10741 ? 186 VAL A N    1 
ATOM   2763 C CA   . VAL A 1 186 ? -25.07613 -25.55691 2.25270   1.000 22.84544 ? 186 VAL A CA   1 
ATOM   2764 C C    . VAL A 1 186 ? -23.71860 -25.98750 1.71691   1.000 23.11422 ? 186 VAL A C    1 
ATOM   2765 O O    . VAL A 1 186 ? -22.78120 -25.19171 1.63973   1.000 21.02876 ? 186 VAL A O    1 
ATOM   2766 C CB   . VAL A 1 186 ? -26.06093 -25.29799 1.10851   1.000 22.73727 ? 186 VAL A CB   1 
ATOM   2767 C CG1  . VAL A 1 186 ? -27.43841 -24.95745 1.68923   1.000 24.81977 ? 186 VAL A CG1  1 
ATOM   2768 C CG2  . VAL A 1 186 ? -25.54553 -24.16204 0.23539   1.000 28.23099 ? 186 VAL A CG2  1 
ATOM   2769 H H    . VAL A 1 186 ? -24.45971 -23.73564 2.60904   1.000 31.32890 ? 186 VAL A H    1 
ATOM   2770 H HA   . VAL A 1 186 ? -25.42175 -26.27853 2.80013   1.000 27.41452 ? 186 VAL A HA   1 
ATOM   2771 H HB   . VAL A 1 186 ? -26.14711 -26.08972 0.55599   1.000 27.28472 ? 186 VAL A HB   1 
ATOM   2772 H HG11 . VAL A 1 186 ? -28.05528 -24.79049 0.95912   1.000 29.78373 ? 186 VAL A HG11 1 
ATOM   2773 H HG12 . VAL A 1 186 ? -27.75000 -25.70502 2.22166   1.000 29.78373 ? 186 VAL A HG12 1 
ATOM   2774 H HG13 . VAL A 1 186 ? -27.36024 -24.16573 2.24375   1.000 29.78373 ? 186 VAL A HG13 1 
ATOM   2775 H HG21 . VAL A 1 186 ? -26.17339 -24.01210 -0.48874  1.000 33.87719 ? 186 VAL A HG21 1 
ATOM   2776 H HG22 . VAL A 1 186 ? -25.46536 -23.36031 0.77491   1.000 33.87719 ? 186 VAL A HG22 1 
ATOM   2777 H HG23 . VAL A 1 186 ? -24.67921 -24.40813 -0.12345  1.000 33.87719 ? 186 VAL A HG23 1 
ATOM   2778 N N    . ASP A 1 187 ? -23.61045 -27.27121 1.37116   1.000 17.38220 ? 187 ASP A N    1 
ATOM   2779 C CA   . ASP A 1 187 ? -22.34884 -27.80688 0.85127   1.000 18.29883 ? 187 ASP A CA   1 
ATOM   2780 C C    . ASP A 1 187 ? -22.30644 -27.63291 -0.67261  1.000 22.86326 ? 187 ASP A C    1 
ATOM   2781 O O    . ASP A 1 187 ? -22.43242 -28.57152 -1.45723  1.000 24.18330 ? 187 ASP A O    1 
ATOM   2782 C CB   . ASP A 1 187 ? -22.11784 -29.25996 1.27046   1.000 20.38826 ? 187 ASP A CB   1 
ATOM   2783 C CG   . ASP A 1 187 ? -23.32106 -30.16582 1.12347   1.000 18.02463 ? 187 ASP A CG   1 
ATOM   2784 O OD1  . ASP A 1 187 ? -24.42628 -29.71145 0.71736   1.000 24.86285 ? 187 ASP A OD1  1 
ATOM   2785 O OD2  . ASP A 1 187 ? -23.10616 -31.38877 1.31380   1.000 18.40849 ? 187 ASP A OD2  1 
ATOM   2786 H H    . ASP A 1 187 ? -24.24602 -27.84775 1.42758   1.000 20.85864 ? 187 ASP A H    1 
ATOM   2787 H HA   . ASP A 1 187 ? -21.63240 -27.27755 1.23485   1.000 21.95859 ? 187 ASP A HA   1 
ATOM   2788 H HB2  . ASP A 1 187 ? -21.40735 -29.62905 0.72248   1.000 24.46591 ? 187 ASP A HB2  1 
ATOM   2789 H HB3  . ASP A 1 187 ? -21.85615 -29.27332 2.20454   1.000 24.46591 ? 187 ASP A HB3  1 
ATOM   2790 N N    . ARG A 1 188 ? -22.03830 -26.38545 -1.05974  1.000 20.33971 ? 188 ARG A N    1 
ATOM   2791 C CA   . ARG A 1 188 ? -21.98616 -25.94456 -2.44545  1.000 25.40695 ? 188 ARG A CA   1 
ATOM   2792 C C    . ARG A 1 188 ? -21.01007 -24.77976 -2.48239  1.000 27.05695 ? 188 ARG A C    1 
ATOM   2793 O O    . ARG A 1 188 ? -20.93603 -24.00529 -1.52789  1.000 28.87064 ? 188 ARG A O    1 
ATOM   2794 C CB   . ARG A 1 188 ? -23.37829 -25.57337 -2.92871  1.000 27.48695 ? 188 ARG A CB   1 
ATOM   2795 C CG   . ARG A 1 188 ? -23.44402 -25.02425 -4.31106  1.000 34.60695 ? 188 ARG A CG   1 
ATOM   2796 C CD   . ARG A 1 188 ? -24.72390 -24.23851 -4.50706  1.000 49.38093 ? 188 ARG A CD   1 
ATOM   2797 N NE   . ARG A 1 188 ? -24.88585 -23.85025 -5.90531  1.000 56.13381 ? 188 ARG A NE   1 
ATOM   2798 C CZ   . ARG A 1 188 ? -25.88931 -23.12904 -6.37966  1.000 58.22424 ? 188 ARG A CZ   1 
ATOM   2799 N NH1  . ARG A 1 188 ? -26.85387 -22.67894 -5.59172  1.000 64.59122 ? 188 ARG A NH1  1 
ATOM   2800 N NH2  . ARG A 1 188 ? -25.92006 -22.84711 -7.67598  1.000 63.03189 ? 188 ARG A NH2  1 
ATOM   2801 H H    . ARG A 1 188 ? -21.87500 -25.74666 -0.50729  1.000 24.40765 ? 188 ARG A H    1 
ATOM   2802 H HA   . ARG A 1 188 ? -21.65840 -26.62592 -3.05376  1.000 30.48833 ? 188 ARG A HA   1 
ATOM   2803 H HB2  . ARG A 1 188 ? -23.93202 -26.36951 -2.90629  1.000 32.98433 ? 188 ARG A HB2  1 
ATOM   2804 H HB3  . ARG A 1 188 ? -23.73976 -24.90039 -2.33155  1.000 32.98433 ? 188 ARG A HB3  1 
ATOM   2805 H HG2  . ARG A 1 188 ? -22.69092 -24.43117 -4.46160  1.000 41.52833 ? 188 ARG A HG2  1 
ATOM   2806 H HG3  . ARG A 1 188 ? -23.42590 -25.75228 -4.95172  1.000 41.52833 ? 188 ARG A HG3  1 
ATOM   2807 H HD2  . ARG A 1 188 ? -25.48284 -24.78612 -4.25017  1.000 59.25711 ? 188 ARG A HD2  1 
ATOM   2808 H HD3  . ARG A 1 188 ? -24.69606 -23.43418 -3.96614  1.000 59.25711 ? 188 ARG A HD3  1 
ATOM   2809 H HE   . ARG A 1 188 ? -24.28445 -24.11024 -6.46192  1.000 67.36058 ? 188 ARG A HE   1 
ATOM   2810 H HH11 . ARG A 1 188 ? -26.83783 -22.85417 -4.74952  1.000 77.50946 ? 188 ARG A HH11 1 
ATOM   2811 H HH12 . ARG A 1 188 ? -27.49577 -22.21133 -5.92231  1.000 77.50946 ? 188 ARG A HH12 1 
ATOM   2812 H HH21 . ARG A 1 188 ? -25.29505 -23.13149 -8.19259  1.000 75.63827 ? 188 ARG A HH21 1 
ATOM   2813 H HH22 . ARG A 1 188 ? -26.56495 -22.37943 -7.99856  1.000 75.63827 ? 188 ARG A HH22 1 
ATOM   2814 N N    . GLN A 1 189 ? -20.21876 -24.70247 -3.55406  1.000 27.99695 ? 189 GLN A N    1 
ATOM   2815 C CA   . GLN A 1 189 ? -19.23956 -23.63160 -3.69306  1.000 30.36877 ? 189 GLN A CA   1 
ATOM   2816 C C    . GLN A 1 189 ? -19.94929 -22.43578 -4.32257  1.000 39.74292 ? 189 GLN A C    1 
ATOM   2817 O O    . GLN A 1 189 ? -19.86907 -22.17697 -5.53538  1.000 31.53633 ? 189 GLN A O    1 
ATOM   2818 C CB   . GLN A 1 189 ? -18.06693 -24.03613 -4.56389  1.000 34.54351 ? 189 GLN A CB   1 
ATOM   2819 C CG   . GLN A 1 189 ? -16.89773 -23.02820 -4.56986  1.000 41.97200 ? 189 GLN A CG   1 
ATOM   2820 C CD   . GLN A 1 189 ? -15.84406 -23.41572 -5.59873  1.000 40.16205 ? 189 GLN A CD   1 
ATOM   2821 O OE1  . GLN A 1 189 ? -15.40513 -24.56936 -5.62728  1.000 45.96952 ? 189 GLN A OE1  1 
ATOM   2822 N NE2  . GLN A 1 189 ? -15.34257 -22.42685 -6.36594  1.000 34.69891 ? 189 GLN A NE2  1 
ATOM   2823 H H    . GLN A 1 189 ? -20.23208 -25.25807 -4.20941  1.000 33.59633 ? 189 GLN A H    1 
ATOM   2824 H HA   . GLN A 1 189 ? -18.90604 -23.41488 -2.80881  1.000 36.44252 ? 189 GLN A HA   1 
ATOM   2825 H HB2  . GLN A 1 189 ? -17.72137 -24.88306 -4.24229  1.000 41.45221 ? 189 GLN A HB2  1 
ATOM   2826 H HB3  . GLN A 1 189 ? -18.37753 -24.12982 -5.47706  1.000 41.45221 ? 189 GLN A HB3  1 
ATOM   2827 H HG2  . GLN A 1 189 ? -17.23435 -22.14633 -4.79343  1.000 50.36640 ? 189 GLN A HG2  1 
ATOM   2828 H HG3  . GLN A 1 189 ? -16.48105 -23.01240 -3.69470  1.000 50.36640 ? 189 GLN A HG3  1 
ATOM   2829 H HE21 . GLN A 1 189 ? -15.62025 -21.61914 -6.26254  1.000 41.63869 ? 189 GLN A HE21 1 
ATOM   2830 H HE22 . GLN A 1 189 ? -14.74522 -22.60401 -6.95884  1.000 41.63869 ? 189 GLN A HE22 1 
ATOM   2831 N N    . THR A 1 190 ? -20.66818 -21.69787 -3.47837  1.000 30.68212 ? 190 THR A N    1 
ATOM   2832 C CA   . THR A 1 190 ? -21.29305 -20.43914 -3.85281  1.000 28.31695 ? 190 THR A CA   1 
ATOM   2833 C C    . THR A 1 190 ? -21.01324 -19.42759 -2.75209  1.000 37.38763 ? 190 THR A C    1 
ATOM   2834 O O    . THR A 1 190 ? -20.68235 -19.79503 -1.62120  1.000 31.08872 ? 190 THR A O    1 
ATOM   2835 C CB   . THR A 1 190 ? -22.81388 -20.56824 -4.03443  1.000 39.22620 ? 190 THR A CB   1 
ATOM   2836 O OG1  . THR A 1 190 ? -23.37682 -21.16741 -2.86100  1.000 51.00945 ? 190 THR A OG1  1 
ATOM   2837 C CG2  . THR A 1 190 ? -23.16577 -21.42577 -5.24208  1.000 41.95368 ? 190 THR A CG2  1 
ATOM   2838 H H    . THR A 1 190 ? -20.81129 -21.91549 -2.65855  1.000 36.81854 ? 190 THR A H    1 
ATOM   2839 H HA   . THR A 1 190 ? -20.91299 -20.13432 -4.69149  1.000 33.98033 ? 190 THR A HA   1 
ATOM   2840 H HB   . THR A 1 190 ? -23.18753 -19.68544 -4.18002  1.000 47.07144 ? 190 THR A HB   1 
ATOM   2841 H HG1  . THR A 1 190 ? -24.12448 -21.50589 -3.04047  1.000 61.21135 ? 190 THR A HG1  1 
ATOM   2842 H HG21 . THR A 1 190 ? -24.12565 -21.55851 -5.28550  1.000 50.34442 ? 190 THR A HG21 1 
ATOM   2843 H HG22 . THR A 1 190 ? -22.87083 -20.99004 -6.05671  1.000 50.34442 ? 190 THR A HG22 1 
ATOM   2844 H HG23 . THR A 1 190 ? -22.73111 -22.29047 -5.17246  1.000 50.34442 ? 190 THR A HG23 1 
ATOM   2845 N N    . ALA A 1 191 ? -21.12715 -18.13848 -3.08334  1.000 33.54525 ? 191 ALA A N    1 
ATOM   2846 C CA   . ALA A 1 191 ? -21.10533 -17.11210 -2.04170  1.000 32.89417 ? 191 ALA A CA   1 
ATOM   2847 C C    . ALA A 1 191 ? -22.21147 -17.39160 -1.03426  1.000 34.72091 ? 191 ALA A C    1 
ATOM   2848 O O    . ALA A 1 191 ? -23.37216 -17.61429 -1.41580  1.000 30.67632 ? 191 ALA A O    1 
ATOM   2849 C CB   . ALA A 1 191 ? -21.29423 -15.72388 -2.64591  1.000 42.74682 ? 191 ALA A CB   1 
ATOM   2850 H H    . ALA A 1 191 ? -21.21510 -17.84005 -3.88518  1.000 40.25430 ? 191 ALA A H    1 
ATOM   2851 H HA   . ALA A 1 191 ? -20.24448 -17.12569 -1.59440  1.000 39.47300 ? 191 ALA A HA   1 
ATOM   2852 H HB1  . ALA A 1 191 ? -21.22600 -15.06126 -1.94047  1.000 51.29618 ? 191 ALA A HB1  1 
ATOM   2853 H HB2  . ALA A 1 191 ? -20.60411 -15.57192 -3.31057  1.000 51.29618 ? 191 ALA A HB2  1 
ATOM   2854 H HB3  . ALA A 1 191 ? -22.16912 -15.67732 -3.06119  1.000 51.29618 ? 191 ALA A HB3  1 
ATOM   2855 N N    . GLN A 1 192 ? -21.85191 -17.40912 0.25986   1.000 31.52836 ? 192 GLN A N    1 
ATOM   2856 C CA   . GLN A 1 192 ? -22.85511 -17.62255 1.29537   1.000 29.66953 ? 192 GLN A CA   1 
ATOM   2857 C C    . GLN A 1 192 ? -22.60330 -16.61804 2.41108   1.000 29.05154 ? 192 GLN A C    1 
ATOM   2858 O O    . GLN A 1 192 ? -21.48953 -16.56448 2.94651   1.000 28.51403 ? 192 GLN A O    1 
ATOM   2859 C CB   . GLN A 1 192 ? -22.76720 -19.02485 1.88754   1.000 22.24327 ? 192 GLN A CB   1 
ATOM   2860 C CG   . GLN A 1 192 ? -23.03800 -20.07343 0.86280   1.000 35.98191 ? 192 GLN A CG   1 
ATOM   2861 C CD   . GLN A 1 192 ? -22.89809 -21.46267 1.41999   1.000 29.47158 ? 192 GLN A CD   1 
ATOM   2862 O OE1  . GLN A 1 192 ? -23.62014 -21.82582 2.36051   1.000 25.66816 ? 192 GLN A OE1  1 
ATOM   2863 N NE2  . GLN A 1 192 ? -21.89235 -22.18858 0.95890   1.000 34.24184 ? 192 GLN A NE2  1 
ATOM   2864 H H    . GLN A 1 192 ? -21.04910 -17.30065 0.54821   1.000 37.83403 ? 192 GLN A H    1 
ATOM   2865 H HA   . GLN A 1 192 ? -23.73508 -17.49001 0.90914   1.000 35.60344 ? 192 GLN A HA   1 
ATOM   2866 H HB2  . GLN A 1 192 ? -21.87521 -19.16736 2.24077   1.000 26.69192 ? 192 GLN A HB2  1 
ATOM   2867 H HB3  . GLN A 1 192 ? -23.42338 -19.11481 2.59625   1.000 26.69192 ? 192 GLN A HB3  1 
ATOM   2868 H HG2  . GLN A 1 192 ? -23.94497 -19.96995 0.53354   1.000 43.17829 ? 192 GLN A HG2  1 
ATOM   2869 H HG3  . GLN A 1 192 ? -22.40682 -19.97648 0.13308   1.000 43.17829 ? 192 GLN A HG3  1 
ATOM   2870 H HE21 . GLN A 1 192 ? -21.35841 -21.85979 0.37029   1.000 41.09020 ? 192 GLN A HE21 1 
ATOM   2871 H HE22 . GLN A 1 192 ? -21.77182 -22.98966 1.24845   1.000 41.09020 ? 192 GLN A HE22 1 
ATOM   2872 N N    . ALA A 1 193 ? -23.62904 -15.86108 2.78419   1.000 28.61117 ? 193 ALA A N    1 
ATOM   2873 C CA   . ALA A 1 193 ? -23.49120 -14.87063 3.84485   1.000 33.59041 ? 193 ALA A CA   1 
ATOM   2874 C C    . ALA A 1 193 ? -23.63314 -15.54158 5.20238   1.000 21.71395 ? 193 ALA A C    1 
ATOM   2875 O O    . ALA A 1 193 ? -24.58463 -16.29248 5.42958   1.000 27.41157 ? 193 ALA A O    1 
ATOM   2876 C CB   . ALA A 1 193 ? -24.55002 -13.77338 3.69815   1.000 31.01601 ? 193 ALA A CB   1 
ATOM   2877 H H    . ALA A 1 193 ? -24.41588 -15.90250 2.43988   1.000 34.33340 ? 193 ALA A H    1 
ATOM   2878 H HA   . ALA A 1 193 ? -22.61350 -14.46089 3.78541   1.000 40.30849 ? 193 ALA A HA   1 
ATOM   2879 H HB1  . ALA A 1 193 ? -24.41180 -13.10670 4.38961   1.000 37.21921 ? 193 ALA A HB1  1 
ATOM   2880 H HB2  . ALA A 1 193 ? -24.46304 -13.36577 2.82343   1.000 37.21921 ? 193 ALA A HB2  1 
ATOM   2881 H HB3  . ALA A 1 193 ? -25.42974 -14.17014 3.79259   1.000 37.21921 ? 193 ALA A HB3  1 
ATOM   2882 N N    . ALA A 1 194 ? -22.68168 -15.27038 6.10789   1.000 27.42065 ? 194 ALA A N    1 
ATOM   2883 C CA   . ALA A 1 194 ? -22.76476 -15.77129 7.47355   1.000 24.09625 ? 194 ALA A CA   1 
ATOM   2884 C C    . ALA A 1 194 ? -23.63179 -14.86250 8.32880   1.000 24.41206 ? 194 ALA A C    1 
ATOM   2885 O O    . ALA A 1 194 ? -24.27977 -15.31661 9.28629   1.000 39.64172 ? 194 ALA A O    1 
ATOM   2886 C CB   . ALA A 1 194 ? -21.36388 -15.88754 8.07897   1.000 24.68361 ? 194 ALA A CB   1 
ATOM   2887 H H    . ALA A 1 194 ? -21.98000 -14.79772 5.95142   1.000 32.90478 ? 194 ALA A H    1 
ATOM   2888 H HA   . ALA A 1 194 ? -23.15305 -16.66059 7.46986   1.000 28.91551 ? 194 ALA A HA   1 
ATOM   2889 H HB1  . ALA A 1 194 ? -21.43187 -16.29614 8.95570   1.000 29.62033 ? 194 ALA A HB1  1 
ATOM   2890 H HB2  . ALA A 1 194 ? -20.81324 -16.43675 7.49983   1.000 29.62033 ? 194 ALA A HB2  1 
ATOM   2891 H HB3  . ALA A 1 194 ? -20.97962 -15.00029 8.15765   1.000 29.62033 ? 194 ALA A HB3  1 
ATOM   2892 N N    . GLY A 1 195 ? -23.67968 -13.59233 7.98757   1.000 23.49136 ? 195 GLY A N    1 
ATOM   2893 C CA   . GLY A 1 195 ? -24.46070 -12.64141 8.73788   1.000 34.89467 ? 195 GLY A CA   1 
ATOM   2894 C C    . GLY A 1 195 ? -23.70148 -12.20957 9.97541   1.000 36.46542 ? 195 GLY A C    1 
ATOM   2895 O O    . GLY A 1 195 ? -22.65317 -12.76096 10.34044  1.000 30.19695 ? 195 GLY A O    1 
ATOM   2896 H H    . GLY A 1 195 ? -23.26171 -13.25358 7.31592   1.000 28.18963 ? 195 GLY A H    1 
ATOM   2897 H HA2  . GLY A 1 195 ? -24.64513 -11.86123 8.19230   1.000 41.87361 ? 195 GLY A HA2  1 
ATOM   2898 H HA3  . GLY A 1 195 ? -25.30048 -13.04425 9.00834   1.000 41.87361 ? 195 GLY A HA3  1 
ATOM   2899 N N    . THR A 1 196 ? -24.24752 -11.20141 10.62884  1.000 30.42077 ? 196 THR A N    1 
ATOM   2900 C CA   . THR A 1 196 ? -23.49745 -10.48043 11.63555  1.000 22.90273 ? 196 THR A CA   1 
ATOM   2901 C C    . THR A 1 196 ? -23.09614 -11.38483 12.79614  1.000 30.64121 ? 196 THR A C    1 
ATOM   2902 O O    . THR A 1 196 ? -23.90773 -12.14281 13.33938  1.000 29.74601 ? 196 THR A O    1 
ATOM   2903 C CB   . THR A 1 196 ? -24.34555 -9.31642  12.13497  1.000 31.46310 ? 196 THR A CB   1 
ATOM   2904 O OG1  . THR A 1 196 ? -24.82974 -8.57511  11.00726  1.000 37.52159 ? 196 THR A OG1  1 
ATOM   2905 C CG2  . THR A 1 196 ? -23.55559 -8.40233  13.01181  1.000 30.86585 ? 196 THR A CG2  1 
ATOM   2906 H H    . THR A 1 196 ? -25.04970 -10.91597 10.50774  1.000 36.50492 ? 196 THR A H    1 
ATOM   2907 H HA   . THR A 1 196 ? -22.67558 -10.14154 11.24705  1.000 27.48328 ? 196 THR A HA   1 
ATOM   2908 H HB   . THR A 1 196 ? -25.08646 -9.66333  12.65750  1.000 37.75572 ? 196 THR A HB   1 
ATOM   2909 H HG1  . THR A 1 196 ? -25.50118 -8.12178  11.22930  1.000 45.02590 ? 196 THR A HG1  1 
ATOM   2910 H HG21 . THR A 1 196 ? -24.07529 -7.60987  13.21912  1.000 37.03902 ? 196 THR A HG21 1 
ATOM   2911 H HG22 . THR A 1 196 ? -23.32552 -8.85265  13.83862  1.000 37.03902 ? 196 THR A HG22 1 
ATOM   2912 H HG23 . THR A 1 196 ? -22.73964 -8.13340  12.56127  1.000 37.03902 ? 196 THR A HG23 1 
ATOM   2913 N N    . ASP A 1 197 ? -21.83533 -11.30206 13.17063  1.000 25.34659 ? 197 ASP A N    1 
ATOM   2914 C CA   . ASP A 1 197 ? -21.40419 -12.00944 14.35635  1.000 29.57682 ? 197 ASP A CA   1 
ATOM   2915 C C    . ASP A 1 197 ? -21.53036 -11.07229 15.56088  1.000 31.20110 ? 197 ASP A C    1 
ATOM   2916 O O    . ASP A 1 197 ? -21.66929 -9.84431  15.42859  1.000 34.20919 ? 197 ASP A O    1 
ATOM   2917 C CB   . ASP A 1 197 ? -19.98573 -12.52323 14.21453  1.000 29.98404 ? 197 ASP A CB   1 
ATOM   2918 C CG   . ASP A 1 197 ? -19.70311 -13.70857 15.14190  1.000 32.94448 ? 197 ASP A CG   1 
ATOM   2919 O OD1  . ASP A 1 197 ? -20.64365 -14.46255 15.51511  1.000 24.84178 ? 197 ASP A OD1  1 
ATOM   2920 O OD2  . ASP A 1 197 ? -18.52508 -13.89484 15.46720  1.000 30.51864 ? 197 ASP A OD2  1 
ATOM   2921 H H    . ASP A 1 197 ? -21.22455 -10.85232 12.76413  1.000 30.41590 ? 197 ASP A H    1 
ATOM   2922 H HA   . ASP A 1 197 ? -21.96062 -12.79098 14.49967  1.000 35.49218 ? 197 ASP A HA   1 
ATOM   2923 H HB2  . ASP A 1 197 ? -19.84218 -12.81355 13.30040  1.000 35.98085 ? 197 ASP A HB2  1 
ATOM   2924 H HB3  . ASP A 1 197 ? -19.36538 -11.81087 14.43619  1.000 35.98085 ? 197 ASP A HB3  1 
ATOM   2925 N N    . THR A 1 198 ? -21.47531 -11.65797 16.73954  1.000 23.86453 ? 198 THR A N    1 
ATOM   2926 C CA   . THR A 1 198 ? -21.45836 -10.89672 17.97902  1.000 23.14243 ? 198 THR A CA   1 
ATOM   2927 C C    . THR A 1 198 ? -20.53612 -11.62058 18.94190  1.000 19.93531 ? 198 THR A C    1 
ATOM   2928 O O    . THR A 1 198 ? -20.18112 -12.79118 18.74930  1.000 22.53785 ? 198 THR A O    1 
ATOM   2929 C CB   . THR A 1 198 ? -22.87470 -10.71919 18.53863  1.000 32.06220 ? 198 THR A CB   1 
ATOM   2930 O OG1  . THR A 1 198 ? -23.52471 -11.99275 18.60361  1.000 34.94309 ? 198 THR A OG1  1 
ATOM   2931 C CG2  . THR A 1 198 ? -23.68613 -9.76027  17.61993  1.000 30.81627 ? 198 THR A CG2  1 
ATOM   2932 H H    . THR A 1 198 ? -21.44567 -12.51002 16.85403  1.000 28.63744 ? 198 THR A H    1 
ATOM   2933 H HA   . THR A 1 198 ? -21.10402 -10.00336 17.84769  1.000 27.77091 ? 198 THR A HA   1 
ATOM   2934 H HB   . THR A 1 198 ? -22.83831 -10.33671 19.42988  1.000 38.47464 ? 198 THR A HB   1 
ATOM   2935 H HG1  . THR A 1 198 ? -23.64919 -12.29037 17.82838  1.000 41.93171 ? 198 THR A HG1  1 
ATOM   2936 H HG21 . THR A 1 198 ? -24.56440 -9.60120  17.99972  1.000 36.97952 ? 198 THR A HG21 1 
ATOM   2937 H HG22 . THR A 1 198 ? -23.22178 -8.91285  17.53262  1.000 36.97952 ? 198 THR A HG22 1 
ATOM   2938 H HG23 . THR A 1 198 ? -23.79051 -10.15481 16.73965  1.000 36.97952 ? 198 THR A HG23 1 
ATOM   2939 N N    . THR A 1 199 ? -20.12107 -10.87588 19.96650  1.000 27.89148 ? 199 THR A N    1 
ATOM   2940 C CA   . THR A 1 199 ? -19.25701 -11.41083 20.99548  1.000 26.27270 ? 199 THR A CA   1 
ATOM   2941 C C    . THR A 1 199 ? -20.09081 -12.13014 22.04274  1.000 23.62682 ? 199 THR A C    1 
ATOM   2942 O O    . THR A 1 199 ? -21.19529 -11.69024 22.41362  1.000 21.36272 ? 199 THR A O    1 
ATOM   2943 C CB   . THR A 1 199 ? -18.44312 -10.29156 21.62446  1.000 21.42777 ? 199 THR A CB   1 
ATOM   2944 O OG1  . THR A 1 199 ? -17.74933 -9.57538  20.60014  1.000 23.39984 ? 199 THR A OG1  1 
ATOM   2945 C CG2  . THR A 1 199 ? -17.40606 -10.80535 22.61150  1.000 18.35758 ? 199 THR A CG2  1 
ATOM   2946 H H    . THR A 1 199 ? -20.33177 -10.05112 20.08194  1.000 33.46978 ? 199 THR A H    1 
ATOM   2947 H HA   . THR A 1 199 ? -18.63337 -12.05010 20.61730  1.000 31.52723 ? 199 THR A HA   1 
ATOM   2948 H HB   . THR A 1 199 ? -19.05775 -9.71635  22.10659  1.000 25.71333 ? 199 THR A HB   1 
ATOM   2949 H HG1  . THR A 1 199 ? -17.11380 -9.13908  20.93463  1.000 28.07981 ? 199 THR A HG1  1 
ATOM   2950 H HG21 . THR A 1 199 ? -16.83675 -10.07607 22.90416  1.000 22.02909 ? 199 THR A HG21 1 
ATOM   2951 H HG22 . THR A 1 199 ? -17.84603 -11.19117 23.38511  1.000 22.02909 ? 199 THR A HG22 1 
ATOM   2952 H HG23 . THR A 1 199 ? -16.85537 -11.48465 22.19128  1.000 22.02909 ? 199 THR A HG23 1 
ATOM   2953 N N    . ILE A 1 200 ? -19.53909 -13.24699 22.52325  1.000 19.10852 ? 200 ILE A N    1 
ATOM   2954 C CA   . ILE A 1 200 ? -20.25870 -14.14012 23.41744  1.000 16.94841 ? 200 ILE A CA   1 
ATOM   2955 C C    . ILE A 1 200 ? -20.03365 -13.55979 24.80388  1.000 20.53640 ? 200 ILE A C    1 
ATOM   2956 O O    . ILE A 1 200 ? -19.05863 -13.87642 25.46703  1.000 16.56621 ? 200 ILE A O    1 
ATOM   2957 C CB   . ILE A 1 200 ? -19.75651 -15.57464 23.29773  1.000 16.52716 ? 200 ILE A CB   1 
ATOM   2958 C CG1  . ILE A 1 200 ? -19.86962 -16.04684 21.85140  1.000 20.37483 ? 200 ILE A CG1  1 
ATOM   2959 C CG2  . ILE A 1 200 ? -20.54911 -16.49084 24.21889  1.000 23.04636 ? 200 ILE A CG2  1 
ATOM   2960 C CD1  . ILE A 1 200 ? -18.84667 -17.12487 21.58610  1.000 18.00752 ? 200 ILE A CD1  1 
ATOM   2961 H H    . ILE A 1 200 ? -18.73982 -13.50724 22.34037  1.000 22.93022 ? 200 ILE A H    1 
ATOM   2962 H HA   . ILE A 1 200 ? -21.20763 -14.13575 23.21611  1.000 20.33809 ? 200 ILE A HA   1 
ATOM   2963 H HB   . ILE A 1 200 ? -18.82358 -15.60206 23.56305  1.000 19.83259 ? 200 ILE A HB   1 
ATOM   2964 H HG12 . ILE A 1 200 ? -20.75528 -16.40945 21.69387  1.000 24.44980 ? 200 ILE A HG12 1 
ATOM   2965 H HG13 . ILE A 1 200 ? -19.70400 -15.30334 21.25092  1.000 24.44980 ? 200 ILE A HG13 1 
ATOM   2966 H HG21 . ILE A 1 200 ? -20.24234 -17.40352 24.09744  1.000 27.65564 ? 200 ILE A HG21 1 
ATOM   2967 H HG22 . ILE A 1 200 ? -20.40665 -16.21330 25.13811  1.000 27.65564 ? 200 ILE A HG22 1 
ATOM   2968 H HG23 . ILE A 1 200 ? -21.49008 -16.42546 23.99560  1.000 27.65564 ? 200 ILE A HG23 1 
ATOM   2969 H HD11 . ILE A 1 200 ? -19.16797 -17.69568 20.87063  1.000 21.60903 ? 200 ILE A HD11 1 
ATOM   2970 H HD12 . ILE A 1 200 ? -18.00991 -16.70804 21.32665  1.000 21.60903 ? 200 ILE A HD12 1 
ATOM   2971 H HD13 . ILE A 1 200 ? -18.72054 -17.64626 22.39382  1.000 21.60903 ? 200 ILE A HD13 1 
ATOM   2972 N N    . THR A 1 201 ? -20.96748 -12.70881 25.25208  1.000 18.85127 ? 201 THR A N    1 
ATOM   2973 C CA   . THR A 1 201 ? -20.79953 -11.94545 26.50161  1.000 17.02846 ? 201 THR A CA   1 
ATOM   2974 C C    . THR A 1 201 ? -20.55424 -12.84299 27.70614  1.000 18.53565 ? 201 THR A C    1 
ATOM   2975 O O    . THR A 1 201 ? -19.68077 -12.55281 28.53063  1.000 18.52394 ? 201 THR A O    1 
ATOM   2976 C CB   . THR A 1 201 ? -22.04629 -11.09759 26.74669  1.000 20.08022 ? 201 THR A CB   1 
ATOM   2977 O OG1  . THR A 1 201 ? -22.37343 -10.40011 25.54700  1.000 19.10917 ? 201 THR A OG1  1 
ATOM   2978 C CG2  . THR A 1 201 ? -21.91254 -10.06522 27.93737  1.000 23.90177 ? 201 THR A CG2  1 
ATOM   2979 H H    . THR A 1 201 ? -21.71247 -12.55216 24.85091  1.000 22.62152 ? 201 THR A H    1 
ATOM   2980 H HA   . THR A 1 201 ? -20.02496 -11.36977 26.40123  1.000 20.43415 ? 201 THR A HA   1 
ATOM   2981 H HB   . THR A 1 201 ? -22.75891 -11.70032 27.00907  1.000 24.09627 ? 201 THR A HB   1 
ATOM   2982 H HG1  . THR A 1 201 ? -23.19655 -10.23375 25.52781  1.000 22.93101 ? 201 THR A HG1  1 
ATOM   2983 H HG21 . THR A 1 201 ? -22.71099 -9.51889  27.99343  1.000 28.68212 ? 201 THR A HG21 1 
ATOM   2984 H HG22 . THR A 1 201 ? -21.79546 -10.53964 28.77512  1.000 28.68212 ? 201 THR A HG22 1 
ATOM   2985 H HG23 . THR A 1 201 ? -21.14594 -9.48952  27.79200  1.000 28.68212 ? 201 THR A HG23 1 
ATOM   2986 N N    . VAL A 1 202 ? -21.30542 -13.93267 27.83020  1.000 18.02642 ? 202 VAL A N    1 
ATOM   2987 C CA   . VAL A 1 202 ? -21.18121 -14.73932 29.03975  1.000 16.71887 ? 202 VAL A CA   1 
ATOM   2988 C C    . VAL A 1 202 ? -19.78875 -15.34525 29.10687  1.000 23.04687 ? 202 VAL A C    1 
ATOM   2989 O O    . VAL A 1 202 ? -19.23996 -15.56049 30.20593  1.000 21.98957 ? 202 VAL A O    1 
ATOM   2990 C CB   . VAL A 1 202 ? -22.27037 -15.81622 29.09170  1.000 22.29676 ? 202 VAL A CB   1 
ATOM   2991 C CG1  . VAL A 1 202 ? -22.10217 -16.81539 27.96214  1.000 23.98450 ? 202 VAL A CG1  1 
ATOM   2992 C CG2  . VAL A 1 202 ? -22.29832 -16.47908 30.45328  1.000 19.54594 ? 202 VAL A CG2  1 
ATOM   2993 H H    . VAL A 1 202 ? -21.87399 -14.21777 27.25083  1.000 21.63170 ? 202 VAL A H    1 
ATOM   2994 H HA   . VAL A 1 202 ? -21.30893 -14.16889 29.81306  1.000 20.06264 ? 202 VAL A HA   1 
ATOM   2995 H HB   . VAL A 1 202 ? -23.13665 -15.39883 28.96265  1.000 26.75611 ? 202 VAL A HB   1 
ATOM   2996 H HG11 . VAL A 1 202 ? -22.88571 -17.38599 27.92551  1.000 28.78140 ? 202 VAL A HG11 1 
ATOM   2997 H HG12 . VAL A 1 202 ? -22.00326 -16.33379 27.12547  1.000 28.78140 ? 202 VAL A HG12 1 
ATOM   2998 H HG13 . VAL A 1 202 ? -21.31081 -17.35186 28.13009  1.000 28.78140 ? 202 VAL A HG13 1 
ATOM   2999 H HG21 . VAL A 1 202 ? -23.11093 -17.00277 30.53267  1.000 23.45513 ? 202 VAL A HG21 1 
ATOM   3000 H HG22 . VAL A 1 202 ? -21.52289 -17.05651 30.53820  1.000 23.45513 ? 202 VAL A HG22 1 
ATOM   3001 H HG23 . VAL A 1 202 ? -22.27711 -15.79348 31.13871  1.000 23.45513 ? 202 VAL A HG23 1 
ATOM   3002 N N    . ASN A 1 203 ? -19.18114 -15.59505 27.94993  1.000 21.62169 ? 203 ASN A N    1 
ATOM   3003 C CA   . ASN A 1 203 ? -17.81671 -16.12395 27.91708  1.000 21.89739 ? 203 ASN A CA   1 
ATOM   3004 C C    . ASN A 1 203 ? -16.79169 -15.05536 28.28310  1.000 19.56004 ? 203 ASN A C    1 
ATOM   3005 O O    . ASN A 1 203 ? -15.81069 -15.34699 28.96127  1.000 19.67058 ? 203 ASN A O    1 
ATOM   3006 C CB   . ASN A 1 203 ? -17.53678 -16.65586 26.50885  1.000 18.79485 ? 203 ASN A CB   1 
ATOM   3007 C CG   . ASN A 1 203 ? -18.26264 -17.95124 26.19580  1.000 17.60405 ? 203 ASN A CG   1 
ATOM   3008 O OD1  . ASN A 1 203 ? -19.08953 -18.43938 26.97120  1.000 18.87780 ? 203 ASN A OD1  1 
ATOM   3009 N ND2  . ASN A 1 203 ? -17.94177 -18.52927 25.03555  1.000 19.47570 ? 203 ASN A ND2  1 
ATOM   3010 H H    . ASN A 1 203 ? -19.53197 -15.46885 27.17488  1.000 25.94603 ? 203 ASN A H    1 
ATOM   3011 H HA   . ASN A 1 203 ? -17.73536 -16.84428 28.56067  1.000 26.27687 ? 203 ASN A HA   1 
ATOM   3012 H HB2  . ASN A 1 203 ? -17.82108 -15.99168 25.86116  1.000 22.55382 ? 203 ASN A HB2  1 
ATOM   3013 H HB3  . ASN A 1 203 ? -16.58462 -16.81904 26.42009  1.000 22.55382 ? 203 ASN A HB3  1 
ATOM   3014 H HD21 . ASN A 1 203 ? -18.32010 -19.26643 24.80297  1.000 23.37084 ? 203 ASN A HD21 1 
ATOM   3015 H HD22 . ASN A 1 203 ? -17.35688 -18.16549 24.51998  1.000 23.37084 ? 203 ASN A HD22 1 
ATOM   3016 N N    . VAL A 1 204 ? -16.97751 -13.81423 27.83480  1.000 18.56293 ? 204 VAL A N    1 
ATOM   3017 C CA   . VAL A 1 204 ? -16.06051 -12.74274 28.23079  1.000 17.51991 ? 204 VAL A CA   1 
ATOM   3018 C C    . VAL A 1 204 ? -16.10018 -12.57071 29.75088  1.000 18.50956 ? 204 VAL A C    1 
ATOM   3019 O O    . VAL A 1 204 ? -15.06450 -12.45929 30.40931  1.000 17.50068 ? 204 VAL A O    1 
ATOM   3020 C CB   . VAL A 1 204 ? -16.39031 -11.42156 27.51848  1.000 17.47265 ? 204 VAL A CB   1 
ATOM   3021 C CG1  . VAL A 1 204 ? -15.51441 -10.28421 28.08050  1.000 17.83456 ? 204 VAL A CG1  1 
ATOM   3022 C CG2  . VAL A 1 204 ? -16.17868 -11.52745 25.98649  1.000 17.75054 ? 204 VAL A CG2  1 
ATOM   3023 H H    . VAL A 1 204 ? -17.61353 -13.56841 27.31073  1.000 22.27552 ? 204 VAL A H    1 
ATOM   3024 H HA   . VAL A 1 204 ? -15.16621 -12.99886 27.95894  1.000 21.02389 ? 204 VAL A HA   1 
ATOM   3025 H HB   . VAL A 1 204 ? -17.32652 -11.22141 27.67828  1.000 20.96718 ? 204 VAL A HB   1 
ATOM   3026 H HG11 . VAL A 1 204 ? -15.51278 -9.54582  27.45095  1.000 21.40147 ? 204 VAL A HG11 1 
ATOM   3027 H HG12 . VAL A 1 204 ? -15.87994 -9.99403  28.93055  1.000 21.40147 ? 204 VAL A HG12 1 
ATOM   3028 H HG13 . VAL A 1 204 ? -14.61019 -10.61457 28.20361  1.000 21.40147 ? 204 VAL A HG13 1 
ATOM   3029 H HG21 . VAL A 1 204 ? -16.62912 -10.78654 25.55279  1.000 21.30064 ? 204 VAL A HG21 1 
ATOM   3030 H HG22 . VAL A 1 204 ? -15.22764 -11.49358 25.79685  1.000 21.30064 ? 204 VAL A HG22 1 
ATOM   3031 H HG23 . VAL A 1 204 ? -16.54890 -12.36755 25.67384  1.000 21.30064 ? 204 VAL A HG23 1 
ATOM   3032 N N    . LEU A 1 205 ? -17.29737 -12.58401 30.32145  1.000 14.87443 ? 205 LEU A N    1 
ATOM   3033 C CA   . LEU A 1 205 ? -17.42395 -12.50701 31.77645  1.000 18.85213 ? 205 LEU A CA   1 
ATOM   3034 C C    . LEU A 1 205 ? -16.73426 -13.67088 32.45398  1.000 16.59428 ? 205 LEU A C    1 
ATOM   3035 O O    . LEU A 1 205 ? -16.07277 -13.49400 33.49632  1.000 19.36856 ? 205 LEU A O    1 
ATOM   3036 C CB   . LEU A 1 205 ? -18.90014 -12.44944 32.18497  1.000 16.06312 ? 205 LEU A CB   1 
ATOM   3037 C CG   . LEU A 1 205 ? -19.58499 -11.16369 31.70252  1.000 22.71481 ? 205 LEU A CG   1 
ATOM   3038 C CD1  . LEU A 1 205 ? -21.08590 -11.33094 31.80688  1.000 27.22277 ? 205 LEU A CD1  1 
ATOM   3039 C CD2  . LEU A 1 205 ? -19.09922 -9.98981  32.53241  1.000 21.43931 ? 205 LEU A CD2  1 
ATOM   3040 H H    . LEU A 1 205 ? -18.04518 -12.63635 29.89915  1.000 17.84932 ? 205 LEU A H    1 
ATOM   3041 H HA   . LEU A 1 205 ? -16.99871 -11.68686 32.07611  1.000 22.62256 ? 205 LEU A HA   1 
ATOM   3042 H HB2  . LEU A 1 205 ? -19.36740 -13.20557 31.79634  1.000 19.27574 ? 205 LEU A HB2  1 
ATOM   3043 H HB3  . LEU A 1 205 ? -18.96346 -12.48209 33.15292  1.000 19.27574 ? 205 LEU A HB3  1 
ATOM   3044 H HG   . LEU A 1 205 ? -19.36581 -10.98194 30.77571  1.000 27.25777 ? 205 LEU A HG   1 
ATOM   3045 H HD11 . LEU A 1 205 ? -21.51448 -10.49314 31.57225  1.000 32.66733 ? 205 LEU A HD11 1 
ATOM   3046 H HD12 . LEU A 1 205 ? -21.36912 -12.02979 31.19635  1.000 32.66733 ? 205 LEU A HD12 1 
ATOM   3047 H HD13 . LEU A 1 205 ? -21.31402 -11.57569 32.71765  1.000 32.66733 ? 205 LEU A HD13 1 
ATOM   3048 H HD21 . LEU A 1 205 ? -19.55276 -9.18499  32.23675  1.000 25.72718 ? 205 LEU A HD21 1 
ATOM   3049 H HD22 . LEU A 1 205 ? -19.29842 -10.15854 33.46624  1.000 25.72718 ? 205 LEU A HD22 1 
ATOM   3050 H HD23 . LEU A 1 205 ? -18.14125 -9.89197  32.41081  1.000 25.72718 ? 205 LEU A HD23 1 
ATOM   3051 N N    . ALA A 1 206 ? -16.89110 -14.87967 31.90318  1.000 17.08090 ? 206 ALA A N    1 
ATOM   3052 C CA   . ALA A 1 206 ? -16.21240 -16.03150 32.50671  1.000 17.88744 ? 206 ALA A CA   1 
ATOM   3053 C C    . ALA A 1 206 ? -14.69756 -15.83030 32.51936  1.000 24.27448 ? 206 ALA A C    1 
ATOM   3054 O O    . ALA A 1 206 ? -14.03971 -16.10241 33.54443  1.000 22.66365 ? 206 ALA A O    1 
ATOM   3055 C CB   . ALA A 1 206 ? -16.60312 -17.31135 31.76678  1.000 18.54203 ? 206 ALA A CB   1 
ATOM   3056 H H    . ALA A 1 206 ? -17.36672 -15.05462 31.20890  1.000 20.49708 ? 206 ALA A H    1 
ATOM   3057 H HA   . ALA A 1 206 ? -16.49865 -16.13029 33.42854  1.000 21.46493 ? 206 ALA A HA   1 
ATOM   3058 H HB1  . ALA A 1 206 ? -16.08566 -18.05116 32.11951  1.000 22.25044 ? 206 ALA A HB1  1 
ATOM   3059 H HB2  . ALA A 1 206 ? -17.55004 -17.47719 31.90034  1.000 22.25044 ? 206 ALA A HB2  1 
ATOM   3060 H HB3  . ALA A 1 206 ? -16.41788 -17.19862 30.82091  1.000 22.25044 ? 206 ALA A HB3  1 
ATOM   3061 N N    . TRP A 1 207 ? -14.14964 -15.26320 31.44591  1.000 20.01701 ? 207 TRP A N    1 
ATOM   3062 C CA   . TRP A 1 207 ? -12.70275 -15.06698 31.33254  1.000 19.23914 ? 207 TRP A CA   1 
ATOM   3063 C C    . TRP A 1 207 ? -12.21696 -13.94715 32.24140  1.000 21.36230 ? 207 TRP A C    1 
ATOM   3064 O O    . TRP A 1 207 ? -11.11809 -14.03462 32.79574  1.000 23.53223 ? 207 TRP A O    1 
ATOM   3065 C CB   . TRP A 1 207 ? -12.34747 -14.78080 29.88384  1.000 23.01254 ? 207 TRP A CB   1 
ATOM   3066 C CG   . TRP A 1 207 ? -10.98872 -14.28949 29.50562  1.000 19.30314 ? 207 TRP A CG   1 
ATOM   3067 C CD1  . TRP A 1 207 ? -9.89003  -15.06047 29.26954  1.000 20.15337 ? 207 TRP A CD1  1 
ATOM   3068 C CD2  . TRP A 1 207 ? -10.62867 -12.95299 29.15957  1.000 18.73645 ? 207 TRP A CD2  1 
ATOM   3069 N NE1  . TRP A 1 207 ? -8.85650  -14.27838 28.83638  1.000 22.67491 ? 207 TRP A NE1  1 
ATOM   3070 C CE2  . TRP A 1 207 ? -9.27750  -12.98066 28.75103  1.000 20.95149 ? 207 TRP A CE2  1 
ATOM   3071 C CE3  . TRP A 1 207 ? -11.31962 -11.73852 29.13208  1.000 22.81914 ? 207 TRP A CE3  1 
ATOM   3072 C CZ2  . TRP A 1 207 ? -8.60026  -11.84888 28.36597  1.000 21.86874 ? 207 TRP A CZ2  1 
ATOM   3073 C CZ3  . TRP A 1 207 ? -10.64439 -10.60775 28.74901  1.000 23.71473 ? 207 TRP A CZ3  1 
ATOM   3074 C CH2  . TRP A 1 207 ? -9.30320  -10.66944 28.35645  1.000 26.12250 ? 207 TRP A CH2  1 
ATOM   3075 H H    . TRP A 1 207 ? -14.59262 -14.98013 30.76493  1.000 24.02041 ? 207 TRP A H    1 
ATOM   3076 H HA   . TRP A 1 207 ? -12.24820 -15.87879 31.60620  1.000 23.08697 ? 207 TRP A HA   1 
ATOM   3077 H HB2  . TRP A 1 207 ? -12.47664 -15.60660 29.39229  1.000 27.61505 ? 207 TRP A HB2  1 
ATOM   3078 H HB3  . TRP A 1 207 ? -12.96889 -14.10610 29.56804  1.000 27.61505 ? 207 TRP A HB3  1 
ATOM   3079 H HD1  . TRP A 1 207 ? -9.84933  -15.98251 29.38498  1.000 24.18405 ? 207 TRP A HD1  1 
ATOM   3080 H HE1  . TRP A 1 207 ? -8.06521  -14.55763 28.64849  1.000 27.20989 ? 207 TRP A HE1  1 
ATOM   3081 H HE3  . TRP A 1 207 ? -12.21774 -11.69838 29.36879  1.000 27.38297 ? 207 TRP A HE3  1 
ATOM   3082 H HZ2  . TRP A 1 207 ? -7.70315  -11.88002 28.12227  1.000 26.24248 ? 207 TRP A HZ2  1 
ATOM   3083 H HZ3  . TRP A 1 207 ? -11.08404 -9.78810  28.75036  1.000 28.45768 ? 207 TRP A HZ3  1 
ATOM   3084 H HH2  . TRP A 1 207 ? -8.87572  -9.89093  28.08108  1.000 31.34700 ? 207 TRP A HH2  1 
ATOM   3085 N N    . LEU A 1 208 ? -13.00887 -12.88389 32.41278  1.000 19.55308 ? 208 LEU A N    1 
ATOM   3086 C CA   . LEU A 1 208 ? -12.67402 -11.90626 33.45750  1.000 19.84952 ? 208 LEU A CA   1 
ATOM   3087 C C    . LEU A 1 208 ? -12.63100 -12.54908 34.84312  1.000 22.50115 ? 208 LEU A C    1 
ATOM   3088 O O    . LEU A 1 208 ? -11.78357 -12.19292 35.66564  1.000 20.84962 ? 208 LEU A O    1 
ATOM   3089 C CB   . LEU A 1 208 ? -13.65994 -10.74104 33.44087  1.000 20.69570 ? 208 LEU A CB   1 
ATOM   3090 C CG   . LEU A 1 208 ? -13.60519 -9.87322  32.18942  1.000 18.66866 ? 208 LEU A CG   1 
ATOM   3091 C CD1  . LEU A 1 208 ? -14.66906 -8.79409  32.21871  1.000 24.36906 ? 208 LEU A CD1  1 
ATOM   3092 C CD2  . LEU A 1 208 ? -12.23565 -9.21102  32.01331  1.000 18.99523 ? 208 LEU A CD2  1 
ATOM   3093 H H    . LEU A 1 208 ? -13.71785 -12.71017 31.95763  1.000 23.46369 ? 208 LEU A H    1 
ATOM   3094 H HA   . LEU A 1 208 ? -11.79123 -11.55344 33.26503  1.000 23.81942 ? 208 LEU A HA   1 
ATOM   3095 H HB2  . LEU A 1 208 ? -14.55968 -11.09880 33.50933  1.000 24.83484 ? 208 LEU A HB2  1 
ATOM   3096 H HB3  . LEU A 1 208 ? -13.47267 -10.16836 34.20129  1.000 24.83484 ? 208 LEU A HB3  1 
ATOM   3097 H HG   . LEU A 1 208 ? -13.76546 -10.45989 31.43300  1.000 22.40239 ? 208 LEU A HG   1 
ATOM   3098 H HD11 . LEU A 1 208 ? -14.64515 -8.30455  31.38102  1.000 29.24287 ? 208 LEU A HD11 1 
ATOM   3099 H HD12 . LEU A 1 208 ? -15.53777 -9.20985  32.33415  1.000 29.24287 ? 208 LEU A HD12 1 
ATOM   3100 H HD13 . LEU A 1 208 ? -14.48780 -8.19240  32.95815  1.000 29.24287 ? 208 LEU A HD13 1 
ATOM   3101 H HD21 . LEU A 1 208 ? -12.33408 -8.42776  31.45076  1.000 22.79427 ? 208 LEU A HD21 1 
ATOM   3102 H HD22 . LEU A 1 208 ? -11.89617 -8.95329  32.88459  1.000 22.79427 ? 208 LEU A HD22 1 
ATOM   3103 H HD23 . LEU A 1 208 ? -11.63000 -9.84429  31.59714  1.000 22.79427 ? 208 LEU A HD23 1 
ATOM   3104 N N    . TYR A 1 209 ? -13.53535 -13.48898 35.12622  1.000 20.23295 ? 209 TYR A N    1 
ATOM   3105 C CA   . TYR A 1 209 ? -13.45722 -14.20870 36.39480  1.000 21.86664 ? 209 TYR A CA   1 
ATOM   3106 C C    . TYR A 1 209 ? -12.15263 -14.98871 36.47478  1.000 24.65143 ? 209 TYR A C    1 
ATOM   3107 O O    . TYR A 1 209 ? -11.42204 -14.91975 37.48308  1.000 23.37784 ? 209 TYR A O    1 
ATOM   3108 C CB   . TYR A 1 209 ? -14.66154 -15.14075 36.54980  1.000 24.07556 ? 209 TYR A CB   1 
ATOM   3109 C CG   . TYR A 1 209 ? -15.86830 -14.45209 37.14980  1.000 24.39050 ? 209 TYR A CG   1 
ATOM   3110 C CD1  . TYR A 1 209 ? -15.87707 -14.06791 38.47904  1.000 22.17809 ? 209 TYR A CD1  1 
ATOM   3111 C CD2  . TYR A 1 209 ? -16.97327 -14.14649 36.37460  1.000 22.56115 ? 209 TYR A CD2  1 
ATOM   3112 C CE1  . TYR A 1 209 ? -16.96179 -13.41711 39.02606  1.000 25.67031 ? 209 TYR A CE1  1 
ATOM   3113 C CE2  . TYR A 1 209 ? -18.06397 -13.49868 36.90762  1.000 23.60422 ? 209 TYR A CE2  1 
ATOM   3114 C CZ   . TYR A 1 209 ? -18.05673 -13.14150 38.23484  1.000 28.57051 ? 209 TYR A CZ   1 
ATOM   3115 O OH   . TYR A 1 209 ? -19.13445 -12.48770 38.80486  1.000 24.07637 ? 209 TYR A OH   1 
ATOM   3116 H H    . TYR A 1 209 ? -14.18698 -13.72118 34.61485  1.000 24.27953 ? 209 TYR A H    1 
ATOM   3117 H HA   . TYR A 1 209 ? -13.48499 -13.57417 37.12818  1.000 26.23997 ? 209 TYR A HA   1 
ATOM   3118 H HB2  . TYR A 1 209 ? -14.91296 -15.47842 35.67651  1.000 28.89067 ? 209 TYR A HB2  1 
ATOM   3119 H HB3  . TYR A 1 209 ? -14.41716 -15.87792 37.13244  1.000 28.89067 ? 209 TYR A HB3  1 
ATOM   3120 H HD1  . TYR A 1 209 ? -15.13812 -14.25165 39.01218  1.000 26.61371 ? 209 TYR A HD1  1 
ATOM   3121 H HD2  . TYR A 1 209 ? -16.97876 -14.38494 35.47545  1.000 27.07338 ? 209 TYR A HD2  1 
ATOM   3122 H HE1  . TYR A 1 209 ? -16.95530 -13.16566 39.92121  1.000 30.80437 ? 209 TYR A HE1  1 
ATOM   3123 H HE2  . TYR A 1 209 ? -18.80094 -13.30294 36.37448  1.000 28.32507 ? 209 TYR A HE2  1 
ATOM   3124 H HH   . TYR A 1 209 ? -18.86411 -11.87780 39.31433  1.000 28.89164 ? 209 TYR A HH   1 
ATOM   3125 N N    . ALA A 1 210 ? -11.84166 -15.73380 35.40243  1.000 23.37286 ? 210 ALA A N    1 
ATOM   3126 C CA   . ALA A 1 210 ? -10.56006 -16.43271 35.28445  1.000 23.91963 ? 210 ALA A CA   1 
ATOM   3127 C C    . ALA A 1 210 ? -9.39791  -15.49296 35.56244  1.000 22.35924 ? 210 ALA A C    1 
ATOM   3128 O O    . ALA A 1 210 ? -8.43285  -15.86761 36.24155  1.000 30.93007 ? 210 ALA A O    1 
ATOM   3129 C CB   . ALA A 1 210 ? -10.43408 -17.04375 33.88512  1.000 24.94219 ? 210 ALA A CB   1 
ATOM   3130 H H    . ALA A 1 210 ? -12.36133 -15.84980 34.72718  1.000 28.04743 ? 210 ALA A H    1 
ATOM   3131 H HA   . ALA A 1 210 ? -10.52672 -17.15208 35.93302  1.000 28.70355 ? 210 ALA A HA   1 
ATOM   3132 H HB1  . ALA A 1 210 ? -9.57071  -17.47901 33.80716  1.000 29.93063 ? 210 ALA A HB1  1 
ATOM   3133 H HB2  . ALA A 1 210 ? -11.14352 -17.69323 33.75847  1.000 29.93063 ? 210 ALA A HB2  1 
ATOM   3134 H HB3  . ALA A 1 210 ? -10.50941 -16.33840 33.22353  1.000 29.93063 ? 210 ALA A HB3  1 
ATOM   3135 N N    . ALA A 1 211 ? -9.47371  -14.26271 35.06818  1.000 21.14441 ? 211 ALA A N    1 
ATOM   3136 C CA   . ALA A 1 211 ? -8.38654  -13.32198 35.29214  1.000 22.06664 ? 211 ALA A CA   1 
ATOM   3137 C C    . ALA A 1 211 ? -8.28938  -12.92281 36.76342  1.000 27.39761 ? 211 ALA A C    1 
ATOM   3138 O O    . ALA A 1 211 ? -7.19365  -12.83128 37.31986  1.000 27.98844 ? 211 ALA A O    1 
ATOM   3139 C CB   . ALA A 1 211 ? -8.57322  -12.08360 34.42384  1.000 25.11662 ? 211 ALA A CB   1 
ATOM   3140 H H    . ALA A 1 211 ? -10.13080 -13.95295 34.60813  1.000 25.37329 ? 211 ALA A H    1 
ATOM   3141 H HA   . ALA A 1 211 ? -7.55311  -13.74916 35.03617  1.000 26.47997 ? 211 ALA A HA   1 
ATOM   3142 H HB1  . ALA A 1 211 ? -7.88081  -11.43918 34.63848  1.000 30.13994 ? 211 ALA A HB1  1 
ATOM   3143 H HB2  . ALA A 1 211 ? -8.50968  -12.33897 33.49070  1.000 30.13994 ? 211 ALA A HB2  1 
ATOM   3144 H HB3  . ALA A 1 211 ? -9.44659  -11.70140 34.60276  1.000 30.13994 ? 211 ALA A HB3  1 
ATOM   3145 N N    . VAL A 1 212 ? -9.42580  -12.67411 37.40817  1.000 26.05779 ? 212 VAL A N    1 
ATOM   3146 C CA   . VAL A 1 212 ? -9.39659  -12.31497 38.82740  1.000 29.38234 ? 212 VAL A CA   1 
ATOM   3147 C C    . VAL A 1 212 ? -8.76198  -13.43295 39.62294  1.000 25.53679 ? 212 VAL A C    1 
ATOM   3148 O O    . VAL A 1 212 ? -7.88746  -13.20478 40.47039  1.000 29.59267 ? 212 VAL A O    1 
ATOM   3149 C CB   . VAL A 1 212 ? -10.81202 -11.99340 39.32110  1.000 26.47680 ? 212 VAL A CB   1 
ATOM   3150 C CG1  . VAL A 1 212 ? -10.86365 -11.88738 40.85015  1.000 26.38419 ? 212 VAL A CG1  1 
ATOM   3151 C CG2  . VAL A 1 212 ? -11.23080 -10.71933 38.66674  1.000 28.46681 ? 212 VAL A CG2  1 
ATOM   3152 H H    . VAL A 1 212 ? -10.21065 -12.70552 37.05788  1.000 31.26935 ? 212 VAL A H    1 
ATOM   3153 H HA   . VAL A 1 212 ? -8.85627  -11.51761 38.94509  1.000 35.25880 ? 212 VAL A HA   1 
ATOM   3154 H HB   . VAL A 1 212 ? -11.42737 -12.70574 39.08645  1.000 31.77217 ? 212 VAL A HB   1 
ATOM   3155 H HG11 . VAL A 1 212 ? -11.76692 -11.65927 41.11997  1.000 31.66102 ? 212 VAL A HG11 1 
ATOM   3156 H HG12 . VAL A 1 212 ? -10.60910 -12.74041 41.23472  1.000 31.66102 ? 212 VAL A HG12 1 
ATOM   3157 H HG13 . VAL A 1 212 ? -10.24730 -11.19707 41.13979  1.000 31.66102 ? 212 VAL A HG13 1 
ATOM   3158 H HG21 . VAL A 1 212 ? -12.06718 -10.42223 39.05863  1.000 34.16018 ? 212 VAL A HG21 1 
ATOM   3159 H HG22 . VAL A 1 212 ? -10.54339 -10.04987 38.81040  1.000 34.16018 ? 212 VAL A HG22 1 
ATOM   3160 H HG23 . VAL A 1 212 ? -11.34734 -10.87483 37.71660  1.000 34.16018 ? 212 VAL A HG23 1 
ATOM   3161 N N    . ILE A 1 213 ? -9.17890  -14.66211 39.34303  1.000 26.74731 ? 213 ILE A N    1 
ATOM   3162 C CA   . ILE A 1 213 ? -8.64421  -15.83211 40.02550  1.000 31.86614 ? 213 ILE A CA   1 
ATOM   3163 C C    . ILE A 1 213 ? -7.13911  -15.90583 39.89199  1.000 37.23546 ? 213 ILE A C    1 
ATOM   3164 O O    . ILE A 1 213 ? -6.44007  -16.35984 40.81995  1.000 30.17108 ? 213 ILE A O    1 
ATOM   3165 C CB   . ILE A 1 213 ? -9.31601  -17.09330 39.46849  1.000 27.83796 ? 213 ILE A CB   1 
ATOM   3166 C CG1  . ILE A 1 213 ? -10.79413 -17.12973 39.87594  1.000 27.95230 ? 213 ILE A CG1  1 
ATOM   3167 C CG2  . ILE A 1 213 ? -8.58921  -18.31803 39.96899  1.000 37.28812 ? 213 ILE A CG2  1 
ATOM   3168 C CD1  . ILE A 1 213 ? -11.57899 -18.29799 39.28095  1.000 28.22275 ? 213 ILE A CD1  1 
ATOM   3169 H H    . ILE A 1 213 ? -9.77855  -14.84823 38.75471  1.000 32.09677 ? 213 ILE A H    1 
ATOM   3170 H HA   . ILE A 1 213 ? -8.84660  -15.76085 40.97147  1.000 38.23937 ? 213 ILE A HA   1 
ATOM   3171 H HB   . ILE A 1 213 ? -9.27168  -17.07667 38.49951  1.000 33.40556 ? 213 ILE A HB   1 
ATOM   3172 H HG12 . ILE A 1 213 ? -10.84741 -17.20136 40.84188  1.000 33.54276 ? 213 ILE A HG12 1 
ATOM   3173 H HG13 . ILE A 1 213 ? -11.21768 -16.30888 39.57930  1.000 33.54276 ? 213 ILE A HG13 1 
ATOM   3174 H HG21 . ILE A 1 213 ? -9.18459  -19.08247 39.91531  1.000 44.74575 ? 213 ILE A HG21 1 
ATOM   3175 H HG22 . ILE A 1 213 ? -7.80690  -18.46906 39.41517  1.000 44.74575 ? 213 ILE A HG22 1 
ATOM   3176 H HG23 . ILE A 1 213 ? -8.31966  -18.17238 40.88917  1.000 44.74575 ? 213 ILE A HG23 1 
ATOM   3177 H HD11 . ILE A 1 213 ? -12.52816 -18.13281 39.39671  1.000 33.86729 ? 213 ILE A HD11 1 
ATOM   3178 H HD12 . ILE A 1 213 ? -11.36960 -18.37024 38.33597  1.000 33.86729 ? 213 ILE A HD12 1 
ATOM   3179 H HD13 . ILE A 1 213 ? -11.32650 -19.11407 39.73953  1.000 33.86729 ? 213 ILE A HD13 1 
ATOM   3180 N N    . ASN A 1 214 ? -6.60206  -15.46570 38.76145  1.000 30.10052 ? 214 ASN A N    1 
ATOM   3181 C CA   . ASN A 1 214 ? -5.17089  -15.56040 38.49589  1.000 27.87454 ? 214 ASN A CA   1 
ATOM   3182 C C    . ASN A 1 214 ? -4.37601  -14.30197 38.82695  1.000 30.33628 ? 214 ASN A C    1 
ATOM   3183 O O    . ASN A 1 214 ? -3.19294  -14.23982 38.49941  1.000 33.53137 ? 214 ASN A O    1 
ATOM   3184 C CB   . ASN A 1 214 ? -4.93508  -15.92331 37.03075  1.000 33.31565 ? 214 ASN A CB   1 
ATOM   3185 C CG   . ASN A 1 214 ? -5.14584  -17.36832 36.77579  1.000 33.19751 ? 214 ASN A CG   1 
ATOM   3186 O OD1  . ASN A 1 214 ? -4.18324  -18.13157 36.80066  1.000 45.56715 ? 214 ASN A OD1  1 
ATOM   3187 N ND2  . ASN A 1 214 ? -6.38142  -17.77413 36.48810  1.000 32.99140 ? 214 ASN A ND2  1 
ATOM   3188 H H    . ASN A 1 214 ? -7.05212  -15.10367 38.12351  1.000 36.12063 ? 214 ASN A H    1 
ATOM   3189 H HA   . ASN A 1 214 ? -4.82552  -16.26847 39.06158  1.000 33.44944 ? 214 ASN A HA   1 
ATOM   3190 H HB2  . ASN A 1 214 ? -5.55328  -15.42446 36.47484  1.000 39.97878 ? 214 ASN A HB2  1 
ATOM   3191 H HB3  . ASN A 1 214 ? -4.02117  -15.70343 36.79121  1.000 39.97878 ? 214 ASN A HB3  1 
ATOM   3192 H HD21 . ASN A 1 214 ? -6.53670  -18.60616 36.33553  1.000 39.58968 ? 214 ASN A HD21 1 
ATOM   3193 H HD22 . ASN A 1 214 ? -7.02386  -17.20362 36.45523  1.000 39.58968 ? 214 ASN A HD22 1 
ATOM   3194 N N    . GLY A 1 215 ? -4.97603  -13.30083 39.45836  1.000 34.28799 ? 215 GLY A N    1 
ATOM   3195 C CA   . GLY A 1 215 ? -4.26812  -12.14557 39.93832  1.000 28.84853 ? 215 GLY A CA   1 
ATOM   3196 C C    . GLY A 1 215 ? -4.46383  -10.88922 39.12302  1.000 41.05264 ? 215 GLY A C    1 
ATOM   3197 O O    . GLY A 1 215 ? -4.11487  -9.80124  39.60982  1.000 31.66453 ? 215 GLY A O    1 
ATOM   3198 H H    . GLY A 1 215 ? -5.82110  -13.27761 39.62207  1.000 41.14559 ? 215 GLY A H    1 
ATOM   3199 H HA2  . GLY A 1 215 ? -4.55959  -11.95736 40.84333  1.000 34.61824 ? 215 GLY A HA2  1 
ATOM   3200 H HA3  . GLY A 1 215 ? -3.31896  -12.34582 39.94653  1.000 34.61824 ? 215 GLY A HA3  1 
ATOM   3201 N N    . ASP A 1 216 ? -4.99131  -10.99488 37.88377  1.000 37.66393 ? 216 ASP A N    1 
ATOM   3202 C CA   . ASP A 1 216 ? -5.25394  -9.82156  37.03840  1.000 34.62769 ? 216 ASP A CA   1 
ATOM   3203 C C    . ASP A 1 216 ? -6.54862  -9.17789  37.51234  1.000 39.48949 ? 216 ASP A C    1 
ATOM   3204 O O    . ASP A 1 216 ? -7.64013  -9.65456  37.19466  1.000 38.56027 ? 216 ASP A O    1 
ATOM   3205 C CB   . ASP A 1 216 ? -5.36213  -10.18574 35.56214  1.000 33.27544 ? 216 ASP A CB   1 
ATOM   3206 C CG   . ASP A 1 216 ? -4.07802  -9.98024  34.79372  1.000 43.73495 ? 216 ASP A CG   1 
ATOM   3207 O OD1  . ASP A 1 216 ? -3.27885  -9.12286  35.20653  1.000 52.66840 ? 216 ASP A OD1  1 
ATOM   3208 O OD2  . ASP A 1 216 ? -3.87312  -10.64743 33.73838  1.000 40.14898 ? 216 ASP A OD2  1 
ATOM   3209 H H    . ASP A 1 216 ? -5.20458  -11.74182 37.51424  1.000 45.19672 ? 216 ASP A H    1 
ATOM   3210 H HA   . ASP A 1 216 ? -4.51347  -9.20304  37.14205  1.000 41.55322 ? 216 ASP A HA   1 
ATOM   3211 H HB2  . ASP A 1 216 ? -5.60536  -11.12189 35.48748  1.000 39.93053 ? 216 ASP A HB2  1 
ATOM   3212 H HB3  . ASP A 1 216 ? -6.04443  -9.63203  35.15224  1.000 39.93053 ? 216 ASP A HB3  1 
ATOM   3213 N N    . ARG A 1 217 ? -6.43276  -8.10228  38.29905  1.000 29.93503 ? 217 ARG A N    1 
ATOM   3214 C CA   . ARG A 1 217 ? -7.57049  -7.47859  38.95803  1.000 29.71412 ? 217 ARG A CA   1 
ATOM   3215 C C    . ARG A 1 217 ? -7.66453  -6.00844  38.58990  1.000 29.54248 ? 217 ARG A C    1 
ATOM   3216 O O    . ARG A 1 217 ? -8.62320  -5.33545  38.99198  1.000 33.50214 ? 217 ARG A O    1 
ATOM   3217 C CB   . ARG A 1 217 ? -7.45990  -7.64244  40.48797  1.000 41.06631 ? 217 ARG A CB   1 
ATOM   3218 H H    . ARG A 1 217 ? -5.68613  -7.70979  38.46755  1.000 35.92204 ? 217 ARG A H    1 
ATOM   3219 H HA   . ARG A 1 217 ? -8.39705  -7.91609  38.70147  1.000 35.65694 ? 217 ARG A HA   1 
ATOM   3220 N N    . TRP A 1 218 ? -6.72764  -5.50620  37.79254  1.000 28.03790 ? 218 TRP A N    1 
ATOM   3221 C CA   . TRP A 1 218 ? -6.67867  -4.08198  37.49944  1.000 32.96752 ? 218 TRP A CA   1 
ATOM   3222 C C    . TRP A 1 218 ? -7.98588  -3.56367  36.92730  1.000 28.79397 ? 218 TRP A C    1 
ATOM   3223 O O    . TRP A 1 218 ? -8.27288  -2.37198  37.06593  1.000 35.65391 ? 218 TRP A O    1 
ATOM   3224 C CB   . TRP A 1 218 ? -5.52758  -3.77447  36.54404  1.000 36.26630 ? 218 TRP A CB   1 
ATOM   3225 C CG   . TRP A 1 218 ? -5.69669  -4.26173  35.11667  1.000 32.62708 ? 218 TRP A CG   1 
ATOM   3226 C CD1  . TRP A 1 218 ? -5.11462  -5.36093  34.56420  1.000 38.44450 ? 218 TRP A CD1  1 
ATOM   3227 C CD2  . TRP A 1 218 ? -6.47880  -3.65771  34.07677  1.000 34.43116 ? 218 TRP A CD2  1 
ATOM   3228 N NE1  . TRP A 1 218 ? -5.47806  -5.47540  33.24200  1.000 32.85691 ? 218 TRP A NE1  1 
ATOM   3229 C CE2  . TRP A 1 218 ? -6.31776  -4.44687  32.92034  1.000 33.38802 ? 218 TRP A CE2  1 
ATOM   3230 C CE3  . TRP A 1 218 ? -7.28368  -2.52331  34.00519  1.000 33.84559 ? 218 TRP A CE3  1 
ATOM   3231 C CZ2  . TRP A 1 218 ? -6.94058  -4.14062  31.71831  1.000 35.80628 ? 218 TRP A CZ2  1 
ATOM   3232 C CZ3  . TRP A 1 218 ? -7.91149  -2.22907  32.81415  1.000 45.27541 ? 218 TRP A CZ3  1 
ATOM   3233 C CH2  . TRP A 1 218 ? -7.73646  -3.03224  31.68771  1.000 41.32782 ? 218 TRP A CH2  1 
ATOM   3234 H H    . TRP A 1 218 ? -6.11114  -5.96747  37.41048  1.000 33.64547 ? 218 TRP A H    1 
ATOM   3235 H HA   . TRP A 1 218 ? -6.51034  -3.60535  38.32679  1.000 39.56103 ? 218 TRP A HA   1 
ATOM   3236 H HB2  . TRP A 1 218 ? -5.41433  -2.81136  36.50567  1.000 43.51956 ? 218 TRP A HB2  1 
ATOM   3237 H HB3  . TRP A 1 218 ? -4.72337  -4.18905  36.89506  1.000 43.51956 ? 218 TRP A HB3  1 
ATOM   3238 H HD1  . TRP A 1 218 ? -4.55231  -5.94976  35.01504  1.000 46.13340 ? 218 TRP A HD1  1 
ATOM   3239 H HE1  . TRP A 1 218 ? -5.21838  -6.09386  32.70471  1.000 39.42829 ? 218 TRP A HE1  1 
ATOM   3240 H HE3  . TRP A 1 218 ? -7.39538  -1.97385  34.74749  1.000 40.61471 ? 218 TRP A HE3  1 
ATOM   3241 H HZ2  . TRP A 1 218 ? -6.81990  -4.66906  30.96303  1.000 42.96753 ? 218 TRP A HZ2  1 
ATOM   3242 H HZ3  . TRP A 1 218 ? -8.46307  -1.48248  32.76141  1.000 54.33049 ? 218 TRP A HZ3  1 
ATOM   3243 H HH2  . TRP A 1 218 ? -8.17136  -2.80610  30.89770  1.000 49.59339 ? 218 TRP A HH2  1 
ATOM   3244 N N    . PHE A 1 219 ? -8.78198  -4.41090  36.26949  1.000 35.13444 ? 219 PHE A N    1 
ATOM   3245 C CA   . PHE A 1 219 ? -9.99914  -3.92647  35.62536  1.000 34.99163 ? 219 PHE A CA   1 
ATOM   3246 C C    . PHE A 1 219 ? -11.18752 -3.87200  36.58098  1.000 29.32205 ? 219 PHE A C    1 
ATOM   3247 O O    . PHE A 1 219 ? -12.24179 -3.35460  36.18992  1.000 32.94717 ? 219 PHE A O    1 
ATOM   3248 C CB   . PHE A 1 219 ? -10.34399 -4.82400  34.41369  1.000 23.01291 ? 219 PHE A CB   1 
ATOM   3249 C CG   . PHE A 1 219 ? -10.35896 -6.26622  34.75079  1.000 22.40497 ? 219 PHE A CG   1 
ATOM   3250 C CD1  . PHE A 1 219 ? -11.48469 -6.85545  35.29303  1.000 23.48243 ? 219 PHE A CD1  1 
ATOM   3251 C CD2  . PHE A 1 219 ? -9.20334  -7.00324  34.65775  1.000 21.08161 ? 219 PHE A CD2  1 
ATOM   3252 C CE1  . PHE A 1 219 ? -11.48476 -8.18167  35.65422  1.000 28.65509 ? 219 PHE A CE1  1 
ATOM   3253 C CE2  . PHE A 1 219 ? -9.18644  -8.31146  35.03295  1.000 22.79886 ? 219 PHE A CE2  1 
ATOM   3254 C CZ   . PHE A 1 219 ? -10.33114 -8.91068  35.53917  1.000 23.77570 ? 219 PHE A CZ   1 
ATOM   3255 H H    . PHE A 1 219 ? -8.63928  -5.25473  36.18602  1.000 42.16132 ? 219 PHE A H    1 
ATOM   3256 H HA   . PHE A 1 219 ? -9.84873  -3.02814  35.29197  1.000 41.98996 ? 219 PHE A HA   1 
ATOM   3257 H HB2  . PHE A 1 219 ? -11.22407 -4.58349  34.08453  1.000 27.61549 ? 219 PHE A HB2  1 
ATOM   3258 H HB3  . PHE A 1 219 ? -9.68086  -4.68504  33.72001  1.000 27.61549 ? 219 PHE A HB3  1 
ATOM   3259 H HD1  . PHE A 1 219 ? -12.25314 -6.34713  35.41608  1.000 28.17892 ? 219 PHE A HD1  1 
ATOM   3260 H HD2  . PHE A 1 219 ? -8.42755  -6.60442  34.33527  1.000 25.29794 ? 219 PHE A HD2  1 
ATOM   3261 H HE1  . PHE A 1 219 ? -12.26255 -8.58049  35.97270  1.000 34.38611 ? 219 PHE A HE1  1 
ATOM   3262 H HE2  . PHE A 1 219 ? -8.40301  -8.80678  34.94992  1.000 27.35863 ? 219 PHE A HE2  1 
ATOM   3263 H HZ   . PHE A 1 219 ? -10.31452 -9.80383  35.79963  1.000 28.53084 ? 219 PHE A HZ   1 
ATOM   3264 N N    . LEU A 1 220 ? -11.04655 -4.37465  37.80772  1.000 30.83158 ? 220 LEU A N    1 
ATOM   3265 C CA   . LEU A 1 220 ? -12.13299 -4.25811  38.78141  1.000 38.59708 ? 220 LEU A CA   1 
ATOM   3266 C C    . LEU A 1 220 ? -12.30729 -2.80451  39.20024  1.000 40.38967 ? 220 LEU A C    1 
ATOM   3267 O O    . LEU A 1 220 ? -11.34697 -2.13499  39.59899  1.000 43.97874 ? 220 LEU A O    1 
ATOM   3268 C CB   . LEU A 1 220 ? -11.87674 -5.12267  40.01996  1.000 37.02082 ? 220 LEU A CB   1 
ATOM   3269 C CG   . LEU A 1 220 ? -11.71145 -6.61437  39.74010  1.000 34.18394 ? 220 LEU A CG   1 
ATOM   3270 C CD1  . LEU A 1 220 ? -11.36730 -7.37088  41.01776  1.000 30.05088 ? 220 LEU A CD1  1 
ATOM   3271 C CD2  . LEU A 1 220 ? -12.93471 -7.26194  39.09527  1.000 35.56081 ? 220 LEU A CD2  1 
ATOM   3272 H H    . LEU A 1 220 ? -10.34533 -4.78027  38.09572  1.000 36.99790 ? 220 LEU A H    1 
ATOM   3273 H HA   . LEU A 1 220 ? -12.94959 -4.57350  38.36392  1.000 46.31650 ? 220 LEU A HA   1 
ATOM   3274 H HB2  . LEU A 1 220 ? -11.06213 -4.81329  40.44644  1.000 44.42498 ? 220 LEU A HB2  1 
ATOM   3275 H HB3  . LEU A 1 220 ? -12.62803 -5.02064  40.62476  1.000 44.42498 ? 220 LEU A HB3  1 
ATOM   3276 H HG   . LEU A 1 220 ? -10.98517 -6.68440  39.10132  1.000 41.02073 ? 220 LEU A HG   1 
ATOM   3277 H HD11 . LEU A 1 220 ? -11.20548 -8.30262  40.79924  1.000 36.06106 ? 220 LEU A HD11 1 
ATOM   3278 H HD12 . LEU A 1 220 ? -10.57175 -6.98049  41.41128  1.000 36.06106 ? 220 LEU A HD12 1 
ATOM   3279 H HD13 . LEU A 1 220 ? -12.11057 -7.30085  41.63654  1.000 36.06106 ? 220 LEU A HD13 1 
ATOM   3280 H HD21 . LEU A 1 220 ? -12.80693 -8.22383  39.07072  1.000 42.67297 ? 220 LEU A HD21 1 
ATOM   3281 H HD22 . LEU A 1 220 ? -13.72006 -7.04689  39.62013  1.000 42.67297 ? 220 LEU A HD22 1 
ATOM   3282 H HD23 . LEU A 1 220 ? -13.03566 -6.91947  38.19345  1.000 42.67297 ? 220 LEU A HD23 1 
ATOM   3283 N N    . ASN A 1 221 ? -13.52865 -2.31742  39.10411  1.000 40.42125 ? 221 ASN A N    1 
ATOM   3284 C CA   . ASN A 1 221 ? -13.85984 -0.91883  39.33486  1.000 46.23002 ? 221 ASN A CA   1 
ATOM   3285 C C    . ASN A 1 221 ? -14.81536 -0.79431  40.51160  1.000 42.09059 ? 221 ASN A C    1 
ATOM   3286 O O    . ASN A 1 221 ? -15.15481 -1.77699  41.17087  1.000 42.57328 ? 221 ASN A O    1 
ATOM   3287 C CB   . ASN A 1 221 ? -14.42491 -0.26750  38.07106  1.000 38.43123 ? 221 ASN A CB   1 
ATOM   3288 C CG   . ASN A 1 221 ? -15.79934 -0.81335  37.68424  1.000 44.08750 ? 221 ASN A CG   1 
ATOM   3289 O OD1  . ASN A 1 221 ? -16.59931 -1.22650  38.51570  1.000 40.35941 ? 221 ASN A OD1  1 
ATOM   3290 N ND2  . ASN A 1 221 ? -16.07991 -0.77778  36.39016  1.000 51.91224 ? 221 ASN A ND2  1 
ATOM   3291 H H    . ASN A 1 221 ? -14.21419 -2.79484  38.89757  1.000 48.50550 ? 221 ASN A H    1 
ATOM   3292 H HA   . ASN A 1 221 ? -13.04730 -0.44332  39.57044  1.000 55.47602 ? 221 ASN A HA   1 
ATOM   3293 H HB2  . ASN A 1 221 ? -14.51273 0.68634   38.22062  1.000 46.11747 ? 221 ASN A HB2  1 
ATOM   3294 H HB3  . ASN A 1 221 ? -13.81852 -0.43356  37.33317  1.000 46.11747 ? 221 ASN A HB3  1 
ATOM   3295 H HD21 . ASN A 1 221 ? -15.50397 -0.46198  35.83356  1.000 62.29469 ? 221 ASN A HD21 1 
ATOM   3296 H HD22 . ASN A 1 221 ? -16.83658 -1.06921  36.10571  1.000 62.29469 ? 221 ASN A HD22 1 
ATOM   3297 N N    . ARG A 1 222 ? -15.20345 0.45121   40.78623  1.000 50.31619 ? 222 ARG A N    1 
ATOM   3298 C CA   . ARG A 1 222 ? -16.02313 0.79385   41.93815  1.000 53.92013 ? 222 ARG A CA   1 
ATOM   3299 C C    . ARG A 1 222 ? -17.48614 0.96691   41.57374  1.000 48.91610 ? 222 ARG A C    1 
ATOM   3300 O O    . ARG A 1 222 ? -18.26284 1.48479   42.38679  1.000 51.49216 ? 222 ARG A O    1 
ATOM   3301 C CB   . ARG A 1 222 ? -15.50038 2.07486   42.59212  1.000 67.37695 ? 222 ARG A CB   1 
ATOM   3302 H H    . ARG A 1 222 ? -14.99582 1.13267   40.30372  1.000 60.37943 ? 222 ARG A H    1 
ATOM   3303 H HA   . ARG A 1 222 ? -15.95678 0.07650   42.58773  1.000 64.70416 ? 222 ARG A HA   1 
ATOM   3304 N N    . PHE A 1 223 ? -17.86939 0.56535   40.36936  1.000 44.91196 ? 223 PHE A N    1 
ATOM   3305 C CA   . PHE A 1 223 ? -19.20338 0.78861   39.84402  1.000 41.51336 ? 223 PHE A CA   1 
ATOM   3306 C C    . PHE A 1 223 ? -19.95234 -0.52799  39.84795  1.000 34.63695 ? 223 PHE A C    1 
ATOM   3307 O O    . PHE A 1 223 ? -19.37552 -1.61362  39.98748  1.000 36.24204 ? 223 PHE A O    1 
ATOM   3308 C CB   . PHE A 1 223 ? -19.15035 1.37652   38.42740  1.000 45.53097 ? 223 PHE A CB   1 
ATOM   3309 C CG   . PHE A 1 223 ? -18.02605 2.34054   38.23740  1.000 43.23730 ? 223 PHE A CG   1 
ATOM   3310 C CD1  . PHE A 1 223 ? -17.57603 3.10023   39.30902  1.000 54.34074 ? 223 PHE A CD1  1 
ATOM   3311 C CD2  . PHE A 1 223 ? -17.37471 2.44880   37.02769  1.000 51.81130 ? 223 PHE A CD2  1 
ATOM   3312 C CE1  . PHE A 1 223 ? -16.50367 3.96417   39.17593  1.000 60.29829 ? 223 PHE A CE1  1 
ATOM   3313 C CE2  . PHE A 1 223 ? -16.30335 3.32274   36.88161  1.000 54.46437 ? 223 PHE A CE2  1 
ATOM   3314 C CZ   . PHE A 1 223 ? -15.87034 4.07942   37.96023  1.000 56.13432 ? 223 PHE A CZ   1 
ATOM   3315 H H    . PHE A 1 223 ? -17.35586 0.14709   39.82228  1.000 53.89436 ? 223 PHE A H    1 
ATOM   3316 H HA   . PHE A 1 223 ? -19.68309 1.42488   40.39725  1.000 49.81603 ? 223 PHE A HA   1 
ATOM   3317 H HB2  . PHE A 1 223 ? -19.03455 0.65301   37.79100  1.000 54.63716 ? 223 PHE A HB2  1 
ATOM   3318 H HB3  . PHE A 1 223 ? -19.98066 1.84497   38.24940  1.000 54.63716 ? 223 PHE A HB3  1 
ATOM   3319 H HD1  . PHE A 1 223 ? -18.00327 3.02739   40.13183  1.000 65.20888 ? 223 PHE A HD1  1 
ATOM   3320 H HD2  . PHE A 1 223 ? -17.65204 1.93302   36.30528  1.000 62.17355 ? 223 PHE A HD2  1 
ATOM   3321 H HE1  . PHE A 1 223 ? -16.21333 4.46395   39.90434  1.000 72.35794 ? 223 PHE A HE1  1 
ATOM   3322 H HE2  . PHE A 1 223 ? -15.87612 3.40059   36.05881  1.000 65.35725 ? 223 PHE A HE2  1 
ATOM   3323 H HZ   . PHE A 1 223 ? -15.15377 4.66405   37.86184  1.000 67.36119 ? 223 PHE A HZ   1 
ATOM   3324 N N    . THR A 1 224 ? -21.25338 -0.41895  39.71956  1.000 28.71695 ? 224 THR A N    1 
ATOM   3325 C CA   . THR A 1 224 ? -22.05334 -1.57138  39.38156  1.000 33.03993 ? 224 THR A CA   1 
ATOM   3326 C C    . THR A 1 224 ? -22.98428 -1.15042  38.25449  1.000 32.66271 ? 224 THR A C    1 
ATOM   3327 O O    . THR A 1 224 ? -22.91900 -0.02206  37.75421  1.000 33.01834 ? 224 THR A O    1 
ATOM   3328 C CB   . THR A 1 224 ? -22.82433 -2.11373  40.58096  1.000 40.36739 ? 224 THR A CB   1 
ATOM   3329 O OG1  . THR A 1 224 ? -23.43921 -3.35599  40.20097  1.000 34.67228 ? 224 THR A OG1  1 
ATOM   3330 C CG2  . THR A 1 224 ? -23.86529 -1.10983  41.02021  1.000 42.74209 ? 224 THR A CG2  1 
ATOM   3331 H H    . THR A 1 224 ? -21.69600 0.31164   39.82285  1.000 34.46033 ? 224 THR A H    1 
ATOM   3332 H HA   . THR A 1 224 ? -21.48366 -2.29574  39.07832  1.000 39.64792 ? 224 THR A HA   1 
ATOM   3333 H HB   . THR A 1 224 ? -22.23548 -2.27073  41.33607  1.000 48.44087 ? 224 THR A HB   1 
ATOM   3334 H HG1  . THR A 1 224 ? -23.95622 -3.61877  40.80763  1.000 41.60674 ? 224 THR A HG1  1 
ATOM   3335 H HG21 . THR A 1 224 ? -24.36328 -1.45669  41.77682  1.000 51.29051 ? 224 THR A HG21 1 
ATOM   3336 H HG22 . THR A 1 224 ? -23.43604 -0.27965  41.27887  1.000 51.29051 ? 224 THR A HG22 1 
ATOM   3337 H HG23 . THR A 1 224 ? -24.48217 -0.93187  40.29210  1.000 51.29051 ? 224 THR A HG23 1 
ATOM   3338 N N    . THR A 1 225 ? -23.87543 -2.03789  37.85863  1.000 31.81126 ? 225 THR A N    1 
ATOM   3339 C CA   . THR A 1 225 ? -24.80732 -1.70497  36.78951  1.000 30.71522 ? 225 THR A CA   1 
ATOM   3340 C C    . THR A 1 225 ? -26.04368 -2.57705  36.94053  1.000 30.52793 ? 225 THR A C    1 
ATOM   3341 O O    . THR A 1 225 ? -26.12932 -3.42467  37.83498  1.000 34.55355 ? 225 THR A O    1 
ATOM   3342 C CB   . THR A 1 225 ? -24.13170 -1.87059  35.41764  1.000 33.58098 ? 225 THR A CB   1 
ATOM   3343 O OG1  . THR A 1 225 ? -25.05459 -1.54768  34.36352  1.000 34.04053 ? 225 THR A OG1  1 
ATOM   3344 C CG2  . THR A 1 225 ? -23.64051 -3.29009  35.23594  1.000 34.76831 ? 225 THR A CG2  1 
ATOM   3345 H H    . THR A 1 225 ? -23.96292 -2.82816  38.18511  1.000 38.17351 ? 225 THR A H    1 
ATOM   3346 H HA   . THR A 1 225 ? -25.09109 -0.78125  36.87398  1.000 36.85826 ? 225 THR A HA   1 
ATOM   3347 H HB   . THR A 1 225 ? -23.37216 -1.27095  35.36628  1.000 40.29718 ? 225 THR A HB   1 
ATOM   3348 H HG1  . THR A 1 225 ? -24.82903 -1.93806  33.65536  1.000 40.84864 ? 225 THR A HG1  1 
ATOM   3349 H HG21 . THR A 1 225 ? -23.18614 -3.37720  34.38305  1.000 41.72197 ? 225 THR A HG21 1 
ATOM   3350 H HG22 . THR A 1 225 ? -23.02158 -3.52003  35.94702  1.000 41.72197 ? 225 THR A HG22 1 
ATOM   3351 H HG23 . THR A 1 225 ? -24.38903 -3.90570  35.25830  1.000 41.72197 ? 225 THR A HG23 1 
ATOM   3352 N N    . THR A 1 226 ? -27.02057 -2.33230  36.08034  1.000 35.14207 ? 226 THR A N    1 
ATOM   3353 C CA   . THR A 1 226 ? -28.18885 -3.18716  35.97440  1.000 33.58096 ? 226 THR A CA   1 
ATOM   3354 C C    . THR A 1 226 ? -28.04370 -4.08529  34.74290  1.000 35.15385 ? 226 THR A C    1 
ATOM   3355 O O    . THR A 1 226 ? -27.25760 -3.81311  33.83834  1.000 28.98973 ? 226 THR A O    1 
ATOM   3356 C CB   . THR A 1 226 ? -29.48546 -2.37612  35.84744  1.000 32.80188 ? 226 THR A CB   1 
ATOM   3357 O OG1  . THR A 1 226 ? -29.55649 -1.75738  34.55880  1.000 37.25189 ? 226 THR A OG1  1 
ATOM   3358 C CG2  . THR A 1 226 ? -29.57170 -1.29385  36.92808  1.000 38.94464 ? 226 THR A CG2  1 
ATOM   3359 H H    . THR A 1 226 ? -27.02791 -1.66397  35.53975  1.000 42.17049 ? 226 THR A H    1 
ATOM   3360 H HA   . THR A 1 226 ? -28.25771 -3.72471  36.77804  1.000 40.29716 ? 226 THR A HA   1 
ATOM   3361 H HB   . THR A 1 226 ? -30.23802 -2.97879  35.95881  1.000 39.36226 ? 226 THR A HB   1 
ATOM   3362 H HG1  . THR A 1 226 ? -30.31772 -1.42092  34.44374  1.000 44.70227 ? 226 THR A HG1  1 
ATOM   3363 H HG21 . THR A 1 226 ? -30.49196 -1.01065  37.04093  1.000 46.73357 ? 226 THR A HG21 1 
ATOM   3364 H HG22 . THR A 1 226 ? -29.24272 -1.64111  37.77198  1.000 46.73357 ? 226 THR A HG22 1 
ATOM   3365 H HG23 . THR A 1 226 ? -29.03522 -0.52727  36.67274  1.000 46.73357 ? 226 THR A HG23 1 
ATOM   3366 N N    . LEU A 1 227 ? -28.84184 -5.15290  34.70696  1.000 35.62332 ? 227 LEU A N    1 
ATOM   3367 C CA   . LEU A 1 227 ? -28.86875 -5.99619  33.51943  1.000 32.56325 ? 227 LEU A CA   1 
ATOM   3368 C C    . LEU A 1 227 ? -29.30398 -5.17080  32.31378  1.000 37.32794 ? 227 LEU A C    1 
ATOM   3369 O O    . LEU A 1 227 ? -28.67557 -5.21964  31.24597  1.000 36.01750 ? 227 LEU A O    1 
ATOM   3370 C CB   . LEU A 1 227 ? -29.79689 -7.18909  33.76936  1.000 34.97192 ? 227 LEU A CB   1 
ATOM   3371 C CG   . LEU A 1 227 ? -29.62659 -8.45344  32.93065  1.000 34.33200 ? 227 LEU A CG   1 
ATOM   3372 C CD1  . LEU A 1 227 ? -28.16625 -8.90331  32.98788  1.000 35.49072 ? 227 LEU A CD1  1 
ATOM   3373 C CD2  . LEU A 1 227 ? -30.49190 -9.56247  33.48866  1.000 29.39069 ? 227 LEU A CD2  1 
ATOM   3374 H H    . LEU A 1 227 ? -29.36287 -5.40371  35.34262  1.000 42.74798 ? 227 LEU A H    1 
ATOM   3375 H HA   . LEU A 1 227 ? -27.98940 -6.35638  33.32852  1.000 39.07590 ? 227 LEU A HA   1 
ATOM   3376 H HB2  . LEU A 1 227 ? -29.68200 -7.45657  34.69424  1.000 41.96630 ? 227 LEU A HB2  1 
ATOM   3377 H HB3  . LEU A 1 227 ? -30.70708 -6.88472  33.62323  1.000 41.96630 ? 227 LEU A HB3  1 
ATOM   3378 H HG   . LEU A 1 227 ? -29.88441 -8.27208  32.01267  1.000 41.19840 ? 227 LEU A HG   1 
ATOM   3379 H HD11 . LEU A 1 227 ? -28.10341 -9.81706  32.66834  1.000 42.58886 ? 227 LEU A HD11 1 
ATOM   3380 H HD12 . LEU A 1 227 ? -27.63352 -8.31854  32.42543  1.000 42.58886 ? 227 LEU A HD12 1 
ATOM   3381 H HD13 . LEU A 1 227 ? -27.85561 -8.85163  33.90602  1.000 42.58886 ? 227 LEU A HD13 1 
ATOM   3382 H HD21 . LEU A 1 227 ? -30.55811 -10.27212 32.83119  1.000 35.26883 ? 227 LEU A HD21 1 
ATOM   3383 H HD22 . LEU A 1 227 ? -30.08492 -9.90165  34.30159  1.000 35.26883 ? 227 LEU A HD22 1 
ATOM   3384 H HD23 . LEU A 1 227 ? -31.37325 -9.20729  33.68356  1.000 35.26883 ? 227 LEU A HD23 1 
ATOM   3385 N N    . ASN A 1 228 ? -30.32372 -4.32171  32.48595  1.000 36.02698 ? 228 ASN A N    1 
ATOM   3386 C CA   . ASN A 1 228 ? -30.84787 -3.61541  31.32020  1.000 38.58943 ? 228 ASN A CA   1 
ATOM   3387 C C    . ASN A 1 228 ? -29.88161 -2.50038  30.89523  1.000 32.34267 ? 228 ASN A C    1 
ATOM   3388 O O    . ASN A 1 228 ? -29.69538 -2.25250  29.70344  1.000 34.36161 ? 228 ASN A O    1 
ATOM   3389 C CB   . ASN A 1 228 ? -32.23742 -3.05671  31.62905  1.000 49.42437 ? 228 ASN A CB   1 
ATOM   3390 C CG   . ASN A 1 228 ? -33.36822 -4.04865  31.27643  1.000 53.54971 ? 228 ASN A CG   1 
ATOM   3391 O OD1  . ASN A 1 228 ? -33.17357 -5.27562  31.28990  1.000 54.54143 ? 228 ASN A OD1  1 
ATOM   3392 N ND2  . ASN A 1 228 ? -34.51441 -3.51781  30.88079  1.000 46.35467 ? 228 ASN A ND2  1 
ATOM   3393 H H    . ASN A 1 228 ? -30.71112 -4.14748  33.23292  1.000 43.23237 ? 228 ASN A H    1 
ATOM   3394 H HA   . ASN A 1 228 ? -30.94312 -4.23203  30.57778  1.000 46.30732 ? 228 ASN A HA   1 
ATOM   3395 H HB2  . ASN A 1 228 ? -32.29565 -2.85885  32.57751  1.000 59.30925 ? 228 ASN A HB2  1 
ATOM   3396 H HB3  . ASN A 1 228 ? -32.37633 -2.24654  31.11268  1.000 59.30925 ? 228 ASN A HB3  1 
ATOM   3397 H HD21 . ASN A 1 228 ? -34.59894 -2.66353  30.83299  1.000 55.62560 ? 228 ASN A HD21 1 
ATOM   3398 H HD22 . ASN A 1 228 ? -35.17513 -4.02751  30.67302  1.000 55.62560 ? 228 ASN A HD22 1 
ATOM   3399 N N    . ASP A 1 229 ? -29.22447 -1.84145  31.85786  1.000 35.73299 ? 229 ASP A N    1 
ATOM   3400 C CA   . ASP A 1 229 ? -28.25017 -0.80846  31.50884  1.000 33.79535 ? 229 ASP A CA   1 
ATOM   3401 C C    . ASP A 1 229 ? -27.05441 -1.45608  30.81487  1.000 35.25805 ? 229 ASP A C    1 
ATOM   3402 O O    . ASP A 1 229 ? -26.58642 -0.97806  29.76933  1.000 29.94546 ? 229 ASP A O    1 
ATOM   3403 C CB   . ASP A 1 229 ? -27.82422 -0.04490  32.77347  1.000 40.72059 ? 229 ASP A CB   1 
ATOM   3404 C CG   . ASP A 1 229 ? -26.56282 0.78822   32.58842  1.000 42.62074 ? 229 ASP A CG   1 
ATOM   3405 O OD1  . ASP A 1 229 ? -26.63640 1.82660   31.87804  1.000 44.37251 ? 229 ASP A OD1  1 
ATOM   3406 O OD2  . ASP A 1 229 ? -25.52376 0.44868   33.18958  1.000 41.30318 ? 229 ASP A OD2  1 
ATOM   3407 H H    . ASP A 1 229 ? -29.32266 -1.97305  32.70175  1.000 42.87959 ? 229 ASP A H    1 
ATOM   3408 H HA   . ASP A 1 229 ? -28.64248 -0.15740  30.90711  1.000 40.55442 ? 229 ASP A HA   1 
ATOM   3409 H HB2  . ASP A 1 229 ? -28.54079 0.55537   33.03258  1.000 48.86470 ? 229 ASP A HB2  1 
ATOM   3410 H HB3  . ASP A 1 229 ? -27.65497 -0.68520  33.48313  1.000 48.86470 ? 229 ASP A HB3  1 
ATOM   3411 N N    . PHE A 1 230 ? -26.58669 -2.59604  31.35233  1.000 35.64263 ? 230 PHE A N    1 
ATOM   3412 C CA   . PHE A 1 230 ? -25.44095 -3.25575  30.74033  1.000 37.70629 ? 230 PHE A CA   1 
ATOM   3413 C C    . PHE A 1 230 ? -25.79612 -3.66515  29.30795  1.000 32.01534 ? 230 PHE A C    1 
ATOM   3414 O O    . PHE A 1 230 ? -25.02197 -3.43096  28.37037  1.000 27.90092 ? 230 PHE A O    1 
ATOM   3415 C CB   . PHE A 1 230 ? -24.99427 -4.46890  31.55774  1.000 29.24786 ? 230 PHE A CB   1 
ATOM   3416 C CG   . PHE A 1 230 ? -24.04832 -5.32668  30.80654  1.000 36.81848 ? 230 PHE A CG   1 
ATOM   3417 C CD1  . PHE A 1 230 ? -22.72060 -4.93956  30.70525  1.000 28.94891 ? 230 PHE A CD1  1 
ATOM   3418 C CD2  . PHE A 1 230 ? -24.47820 -6.43059  30.10171  1.000 33.69596 ? 230 PHE A CD2  1 
ATOM   3419 C CE1  . PHE A 1 230 ? -21.82776 -5.65539  29.95212  1.000 29.96319 ? 230 PHE A CE1  1 
ATOM   3420 C CE2  . PHE A 1 230 ? -23.57635 -7.16942  29.36057  1.000 29.79089 ? 230 PHE A CE2  1 
ATOM   3421 C CZ   . PHE A 1 230 ? -22.25863 -6.78432  29.28627  1.000 34.66669 ? 230 PHE A CZ   1 
ATOM   3422 H H    . PHE A 1 230 ? -26.90962 -2.98773  32.04697  1.000 42.77115 ? 230 PHE A H    1 
ATOM   3423 H HA   . PHE A 1 230 ? -24.68743 -2.64414  30.72797  1.000 45.24755 ? 230 PHE A HA   1 
ATOM   3424 H HB2  . PHE A 1 230 ? -24.55180 -4.16404  32.36508  1.000 35.09744 ? 230 PHE A HB2  1 
ATOM   3425 H HB3  . PHE A 1 230 ? -25.77193 -5.00266  31.78613  1.000 35.09744 ? 230 PHE A HB3  1 
ATOM   3426 H HD1  . PHE A 1 230 ? -22.43036 -4.17961  31.15582  1.000 34.73870 ? 230 PHE A HD1  1 
ATOM   3427 H HD2  . PHE A 1 230 ? -25.37401 -6.67832  30.12624  1.000 40.43515 ? 230 PHE A HD2  1 
ATOM   3428 H HE1  . PHE A 1 230 ? -20.94095 -5.38365  29.89160  1.000 35.95583 ? 230 PHE A HE1  1 
ATOM   3429 H HE2  . PHE A 1 230 ? -23.86258 -7.93037  28.90900  1.000 35.74907 ? 230 PHE A HE2  1 
ATOM   3430 H HZ   . PHE A 1 230 ? -21.65605 -7.28553  28.78618  1.000 41.60003 ? 230 PHE A HZ   1 
ATOM   3431 N N    . ASN A 1 231 ? -27.00662 -4.20099  29.10919  1.000 29.91409 ? 231 ASN A N    1 
ATOM   3432 C CA   . ASN A 1 231 ? -27.41680 -4.64050  27.77777  1.000 31.34380 ? 231 ASN A CA   1 
ATOM   3433 C C    . ASN A 1 231 ? -27.51935 -3.50496  26.77744  1.000 36.43085 ? 231 ASN A C    1 
ATOM   3434 O O    . ASN A 1 231 ? -27.38473 -3.75512  25.57933  1.000 35.61372 ? 231 ASN A O    1 
ATOM   3435 C CB   . ASN A 1 231 ? -28.74523 -5.38760  27.84685  1.000 37.41578 ? 231 ASN A CB   1 
ATOM   3436 C CG   . ASN A 1 231 ? -28.55725 -6.81572  28.28903  1.000 32.45603 ? 231 ASN A CG   1 
ATOM   3437 O OD1  . ASN A 1 231 ? -27.45578 -7.34477  28.15809  1.000 34.94966 ? 231 ASN A OD1  1 
ATOM   3438 N ND2  . ASN A 1 231 ? -29.61392 -7.45387  28.78826  1.000 29.35302 ? 231 ASN A ND2  1 
ATOM   3439 H H    . ASN A 1 231 ? -27.59874 -4.31784  29.72291  1.000 35.89690 ? 231 ASN A H    1 
ATOM   3440 H HA   . ASN A 1 231 ? -26.74120 -5.25576  27.45063  1.000 37.61256 ? 231 ASN A HA   1 
ATOM   3441 H HB2  . ASN A 1 231 ? -29.32781 -4.94546  28.48391  1.000 44.89893 ? 231 ASN A HB2  1 
ATOM   3442 H HB3  . ASN A 1 231 ? -29.15692 -5.39139  26.96870  1.000 44.89893 ? 231 ASN A HB3  1 
ATOM   3443 H HD21 . ASN A 1 231 ? -29.53936 -8.26997  29.04879  1.000 35.22363 ? 231 ASN A HD21 1 
ATOM   3444 H HD22 . ASN A 1 231 ? -30.37026 -7.05051  28.84925  1.000 35.22363 ? 231 ASN A HD22 1 
ATOM   3445 N N    . LEU A 1 232 ? -27.75550 -2.26743  27.22712  1.000 34.66975 ? 232 LEU A N    1 
ATOM   3446 C CA   . LEU A 1 232 ? -27.72707 -1.13484  26.30583  1.000 30.35759 ? 232 LEU A CA   1 
ATOM   3447 C C    . LEU A 1 232 ? -26.31908 -0.89440  25.79047  1.000 29.70532 ? 232 LEU A C    1 
ATOM   3448 O O    . LEU A 1 232 ? -26.13604 -0.43655  24.65482  1.000 32.64030 ? 232 LEU A O    1 
ATOM   3449 C CB   . LEU A 1 232 ? -28.25631 0.10531   27.01140  1.000 34.11273 ? 232 LEU A CB   1 
ATOM   3450 C CG   . LEU A 1 232 ? -29.76301 0.26203   26.83469  1.000 41.73532 ? 232 LEU A CG   1 
ATOM   3451 C CD1  . LEU A 1 232 ? -30.11268 1.68501   27.23576  1.000 46.99059 ? 232 LEU A CD1  1 
ATOM   3452 C CD2  . LEU A 1 232 ? -30.22516 0.00701   25.40963  1.000 43.41853 ? 232 LEU A CD2  1 
ATOM   3453 H H    . LEU A 1 232 ? -27.93095 -2.06307  28.04318  1.000 41.60370 ? 232 LEU A H    1 
ATOM   3454 H HA   . LEU A 1 232 ? -28.30066 -1.31483  25.54551  1.000 36.42911 ? 232 LEU A HA   1 
ATOM   3455 H HB2  . LEU A 1 232 ? -28.06766 0.03650   27.96045  1.000 40.93528 ? 232 LEU A HB2  1 
ATOM   3456 H HB3  . LEU A 1 232 ? -27.82336 0.89011   26.64297  1.000 40.93528 ? 232 LEU A HB3  1 
ATOM   3457 H HG   . LEU A 1 232 ? -30.22127 -0.39351  27.38297  1.000 50.08239 ? 232 LEU A HG   1 
ATOM   3458 H HD11 . LEU A 1 232 ? -31.06876 1.81643   27.13441  1.000 56.38871 ? 232 LEU A HD11 1 
ATOM   3459 H HD12 . LEU A 1 232 ? -29.85678 1.82398   28.16087  1.000 56.38871 ? 232 LEU A HD12 1 
ATOM   3460 H HD13 . LEU A 1 232 ? -29.63150 2.30223   26.66312  1.000 56.38871 ? 232 LEU A HD13 1 
ATOM   3461 H HD21 . LEU A 1 232 ? -31.18773 0.12182   25.36365  1.000 52.10224 ? 232 LEU A HD21 1 
ATOM   3462 H HD22 . LEU A 1 232 ? -29.78815 0.63934   24.81796  1.000 52.10224 ? 232 LEU A HD22 1 
ATOM   3463 H HD23 . LEU A 1 232 ? -29.98819 -0.89913  25.15834  1.000 52.10224 ? 232 LEU A HD23 1 
ATOM   3464 N N    . VAL A 1 233 ? -25.32113 -1.19111  26.61264  1.000 30.22162 ? 233 VAL A N    1 
ATOM   3465 C CA   . VAL A 1 233 ? -23.94606 -1.07974  26.16619  1.000 29.26679 ? 233 VAL A CA   1 
ATOM   3466 C C    . VAL A 1 233 ? -23.57280 -2.28692  25.31258  1.000 31.12776 ? 233 VAL A C    1 
ATOM   3467 O O    . VAL A 1 233 ? -22.83356 -2.15873  24.33492  1.000 32.44767 ? 233 VAL A O    1 
ATOM   3468 C CB   . VAL A 1 233 ? -23.01461 -0.92974  27.37562  1.000 35.59511 ? 233 VAL A CB   1 
ATOM   3469 C CG1  . VAL A 1 233 ? -21.59433 -0.79243  26.91529  1.000 37.75351 ? 233 VAL A CG1  1 
ATOM   3470 C CG2  . VAL A 1 233 ? -23.45856 0.25767   28.20204  1.000 40.15105 ? 233 VAL A CG2  1 
ATOM   3471 H H    . VAL A 1 233 ? -25.41521 -1.45669  27.42544  1.000 36.26594 ? 233 VAL A H    1 
ATOM   3472 H HA   . VAL A 1 233 ? -23.85250 -0.28433  25.61972  1.000 35.12015 ? 233 VAL A HA   1 
ATOM   3473 H HB   . VAL A 1 233 ? -23.05920 -1.71956  27.93783  1.000 42.71413 ? 233 VAL A HB   1 
ATOM   3474 H HG11 . VAL A 1 233 ? -21.01879 -0.69783  27.69082  1.000 45.30421 ? 233 VAL A HG11 1 
ATOM   3475 H HG12 . VAL A 1 233 ? -21.34602 -1.58406  26.41349  1.000 45.30421 ? 233 VAL A HG12 1 
ATOM   3476 H HG13 . VAL A 1 233 ? -21.52001 -0.00683  26.35092  1.000 45.30421 ? 233 VAL A HG13 1 
ATOM   3477 H HG21 . VAL A 1 233 ? -22.86744 0.34913   28.96600  1.000 48.18127 ? 233 VAL A HG21 1 
ATOM   3478 H HG22 . VAL A 1 233 ? -23.41629 1.05713   27.65411  1.000 48.18127 ? 233 VAL A HG22 1 
ATOM   3479 H HG23 . VAL A 1 233 ? -24.36792 0.11002   28.50365  1.000 48.18127 ? 233 VAL A HG23 1 
ATOM   3480 N N    . ALA A 1 234 ? -24.05299 -3.47553  25.68868  1.000 30.40078 ? 234 ALA A N    1 
ATOM   3481 C CA   . ALA A 1 234 ? -23.76176 -4.66581  24.89405  1.000 32.67310 ? 234 ALA A CA   1 
ATOM   3482 C C    . ALA A 1 234 ? -24.20842 -4.45328  23.45202  1.000 36.01329 ? 234 ALA A C    1 
ATOM   3483 O O    . ALA A 1 234 ? -23.43492 -4.66307  22.49816  1.000 30.15530 ? 234 ALA A O    1 
ATOM   3484 C CB   . ALA A 1 234 ? -24.43501 -5.88373  25.51706  1.000 25.70960 ? 234 ALA A CB   1 
ATOM   3485 H H    . ALA A 1 234 ? -24.53912 -3.61535  26.38442  1.000 36.48093 ? 234 ALA A H    1 
ATOM   3486 H HA   . ALA A 1 234 ? -22.80662 -4.83605  24.89228  1.000 39.20772 ? 234 ALA A HA   1 
ATOM   3487 H HB1  . ALA A 1 234 ? -24.25520 -6.66025  24.96464  1.000 30.85153 ? 234 ALA A HB1  1 
ATOM   3488 H HB2  . ALA A 1 234 ? -24.07622 -6.02100  26.40810  1.000 30.85153 ? 234 ALA A HB2  1 
ATOM   3489 H HB3  . ALA A 1 234 ? -25.39015 -5.72552  25.56582  1.000 30.85153 ? 234 ALA A HB3  1 
ATOM   3490 N N    . MET A 1 235 ? -25.45074 -3.97816  23.27488  1.000 37.31109 ? 235 MET A N    1 
ATOM   3491 C CA   . MET A 1 235 ? -25.97845 -3.74175  21.93283  1.000 34.01319 ? 235 MET A CA   1 
ATOM   3492 C C    . MET A 1 235 ? -25.11595 -2.76458  21.14674  1.000 36.25807 ? 235 MET A C    1 
ATOM   3493 O O    . MET A 1 235 ? -24.86737 -2.96764  19.95070  1.000 33.43937 ? 235 MET A O    1 
ATOM   3494 C CB   . MET A 1 235 ? -27.41290 -3.22796  22.04465  1.000 48.76779 ? 235 MET A CB   1 
ATOM   3495 C CG   . MET A 1 235 ? -28.46295 -4.25857  21.67464  1.000 54.09449 ? 235 MET A CG   1 
ATOM   3496 S SD   . MET A 1 235 ? -30.03932 -3.55950  21.13951  1.000 81.32899 ? 235 MET A SD   1 
ATOM   3497 C CE   . MET A 1 235 ? -30.80416 -3.20108  22.72147  1.000 59.49228 ? 235 MET A CE   1 
ATOM   3498 H H    . MET A 1 235 ? -25.99811 -3.78798  23.90980  1.000 44.77331 ? 235 MET A H    1 
ATOM   3499 H HA   . MET A 1 235 ? -25.98761 -4.58246  21.44831  1.000 40.81582 ? 235 MET A HA   1 
ATOM   3500 H HB2  . MET A 1 235 ? -27.57544 -2.95466  22.96076  1.000 58.52135 ? 235 MET A HB2  1 
ATOM   3501 H HB3  . MET A 1 235 ? -27.51929 -2.46968  21.44908  1.000 58.52135 ? 235 MET A HB3  1 
ATOM   3502 H HG2  . MET A 1 235 ? -28.12126 -4.80085  20.94643  1.000 64.91338 ? 235 MET A HG2  1 
ATOM   3503 H HG3  . MET A 1 235 ? -28.63778 -4.81419  22.44924  1.000 64.91338 ? 235 MET A HG3  1 
ATOM   3504 H HE1  . MET A 1 235 ? -31.67243 -2.79767  22.56741  1.000 71.39073 ? 235 MET A HE1  1 
ATOM   3505 H HE2  . MET A 1 235 ? -30.90768 -4.02847  23.21692  1.000 71.39073 ? 235 MET A HE2  1 
ATOM   3506 H HE3  . MET A 1 235 ? -30.23682 -2.58893  23.21504  1.000 71.39073 ? 235 MET A HE3  1 
ATOM   3507 N N    . LYS A 1 236 ? -24.64803 -1.70061  21.79456  1.000 30.60337 ? 236 LYS A N    1 
ATOM   3508 C CA   . LYS A 1 236 ? -23.82556 -0.71852  21.09946  1.000 31.27270 ? 236 LYS A CA   1 
ATOM   3509 C C    . LYS A 1 236 ? -22.52690 -1.33619  20.61354  1.000 30.99680 ? 236 LYS A C    1 
ATOM   3510 O O    . LYS A 1 236 ? -21.99185 -0.93413  19.58197  1.000 29.30363 ? 236 LYS A O    1 
ATOM   3511 C CB   . LYS A 1 236 ? -23.54484 0.46612   22.03929  1.000 38.63539 ? 236 LYS A CB   1 
ATOM   3512 C CG   . LYS A 1 236 ? -22.52963 1.48165   21.53154  1.000 33.41673 ? 236 LYS A CG   1 
ATOM   3513 C CD   . LYS A 1 236 ? -22.41351 2.63525   22.53880  1.000 45.27253 ? 236 LYS A CD   1 
ATOM   3514 C CE   . LYS A 1 236 ? -21.24596 3.58127   22.26649  1.000 42.85144 ? 236 LYS A CE   1 
ATOM   3515 N NZ   . LYS A 1 236 ? -21.27288 4.18891   20.90947  1.000 51.08750 ? 236 LYS A NZ   1 
ATOM   3516 H H    . LYS A 1 236 ? -24.79046 -1.52723  22.62462  1.000 36.72405 ? 236 LYS A H    1 
ATOM   3517 H HA   . LYS A 1 236 ? -24.30255 -0.38242  20.32450  1.000 37.52725 ? 236 LYS A HA   1 
ATOM   3518 H HB2  . LYS A 1 236 ? -24.37771 0.94021   22.18884  1.000 46.36247 ? 236 LYS A HB2  1 
ATOM   3519 H HB3  . LYS A 1 236 ? -23.20672 0.11569   22.87892  1.000 46.36247 ? 236 LYS A HB3  1 
ATOM   3520 H HG2  . LYS A 1 236 ? -21.66116 1.05999   21.43659  1.000 40.10008 ? 236 LYS A HG2  1 
ATOM   3521 H HG3  . LYS A 1 236 ? -22.82040 1.83865   20.67822  1.000 40.10008 ? 236 LYS A HG3  1 
ATOM   3522 H HD2  . LYS A 1 236 ? -23.22969 3.15803   22.50771  1.000 54.32704 ? 236 LYS A HD2  1 
ATOM   3523 H HD3  . LYS A 1 236 ? -22.29076 2.26297   23.42588  1.000 54.32704 ? 236 LYS A HD3  1 
ATOM   3524 H HE2  . LYS A 1 236 ? -21.26995 4.30261   22.91429  1.000 51.42172 ? 236 LYS A HE2  1 
ATOM   3525 H HE3  . LYS A 1 236 ? -20.41568 3.08572   22.35222  1.000 51.42172 ? 236 LYS A HE3  1 
ATOM   3526 H HZ1  . LYS A 1 236 ? -20.57192 4.72725   20.80339  1.000 61.30500 ? 236 LYS A HZ1  1 
ATOM   3527 H HZ2  . LYS A 1 236 ? -21.24376 3.55151   20.28984  1.000 61.30500 ? 236 LYS A HZ2  1 
ATOM   3528 H HZ3  . LYS A 1 236 ? -22.01881 4.66285   20.80334  1.000 61.30500 ? 236 LYS A HZ3  1 
ATOM   3529 N N    . TYR A 1 237 ? -22.00638 -2.31223  21.34912  1.000 32.35991 ? 237 TYR A N    1 
ATOM   3530 C CA   . TYR A 1 237 ? -20.72678 -2.93002  21.04719  1.000 31.39884 ? 237 TYR A CA   1 
ATOM   3531 C C    . TYR A 1 237 ? -20.86646 -4.31476  20.44129  1.000 31.27589 ? 237 TYR A C    1 
ATOM   3532 O O    . TYR A 1 237 ? -19.85685 -5.02486  20.28820  1.000 26.50727 ? 237 TYR A O    1 
ATOM   3533 C CB   . TYR A 1 237 ? -19.91423 -2.93417  22.33447  1.000 28.01150 ? 237 TYR A CB   1 
ATOM   3534 C CG   . TYR A 1 237 ? -19.39646 -1.54997  22.67751  1.000 27.40599 ? 237 TYR A CG   1 
ATOM   3535 C CD1  . TYR A 1 237 ? -18.20562 -1.10069  22.14021  1.000 34.50901 ? 237 TYR A CD1  1 
ATOM   3536 C CD2  . TYR A 1 237 ? -20.11043 -0.69205  23.50379  1.000 31.56436 ? 237 TYR A CD2  1 
ATOM   3537 C CE1  . TYR A 1 237 ? -17.70272 0.14253   22.43715  1.000 40.42521 ? 237 TYR A CE1  1 
ATOM   3538 C CE2  . TYR A 1 237 ? -19.62055 0.57515   23.81574  1.000 32.28847 ? 237 TYR A CE2  1 
ATOM   3539 C CZ   . TYR A 1 237 ? -18.40469 0.99246   23.26243  1.000 31.47252 ? 237 TYR A CZ   1 
ATOM   3540 O OH   . TYR A 1 237 ? -17.86177 2.23973   23.52639  1.000 35.76860 ? 237 TYR A OH   1 
ATOM   3541 H H    . TYR A 1 237 ? -22.38836 -2.64096  22.04578  1.000 38.83190 ? 237 TYR A H    1 
ATOM   3542 H HA   . TYR A 1 237 ? -20.24095 -2.41923  20.38067  1.000 37.67861 ? 237 TYR A HA   1 
ATOM   3543 H HB2  . TYR A 1 237 ? -20.47525 -3.23907  23.06509  1.000 33.61380 ? 237 TYR A HB2  1 
ATOM   3544 H HB3  . TYR A 1 237 ? -19.15372 -3.52650  22.23038  1.000 33.61380 ? 237 TYR A HB3  1 
ATOM   3545 H HD1  . TYR A 1 237 ? -17.73198 -1.65496  21.56203  1.000 41.41081 ? 237 TYR A HD1  1 
ATOM   3546 H HD2  . TYR A 1 237 ? -20.92734 -0.96691  23.85333  1.000 37.87723 ? 237 TYR A HD2  1 
ATOM   3547 H HE1  . TYR A 1 237 ? -16.88680 0.41140   22.08060  1.000 48.51025 ? 237 TYR A HE1  1 
ATOM   3548 H HE2  . TYR A 1 237 ? -20.09620 1.13642   24.38492  1.000 38.74617 ? 237 TYR A HE2  1 
ATOM   3549 H HH   . TYR A 1 237 ? -18.36230 2.66601   24.04847  1.000 42.92231 ? 237 TYR A HH   1 
ATOM   3550 N N    . ASN A 1 238 ? -22.08102 -4.69148  20.03662  1.000 27.64450 ? 238 ASN A N    1 
ATOM   3551 C CA   . ASN A 1 238 ? -22.31578 -5.94123  19.32477  1.000 25.65202 ? 238 ASN A CA   1 
ATOM   3552 C C    . ASN A 1 238 ? -21.86115 -7.10940  20.19021  1.000 25.69357 ? 238 ASN A C    1 
ATOM   3553 O O    . ASN A 1 238 ? -21.11530 -7.98754  19.76493  1.000 25.69701 ? 238 ASN A O    1 
ATOM   3554 C CB   . ASN A 1 238 ? -21.63631 -5.91484  17.95503  1.000 31.68893 ? 238 ASN A CB   1 
ATOM   3555 C CG   . ASN A 1 238 ? -22.18138 -4.79410  17.06493  1.000 42.74201 ? 238 ASN A CG   1 
ATOM   3556 O OD1  . ASN A 1 238 ? -23.36952 -4.74819  16.74640  1.000 44.50994 ? 238 ASN A OD1  1 
ATOM   3557 N ND2  . ASN A 1 238 ? -21.29951 -3.88504  16.65746  1.000 48.49692 ? 238 ASN A ND2  1 
ATOM   3558 H H    . ASN A 1 238 ? -22.79544 -4.22913  20.16566  1.000 33.17340 ? 238 ASN A H    1 
ATOM   3559 H HA   . ASN A 1 238 ? -23.26262 -6.06388  19.15536  1.000 30.78242 ? 238 ASN A HA   1 
ATOM   3560 H HB2  . ASN A 1 238 ? -20.68404 -5.77152  18.07418  1.000 38.02672 ? 238 ASN A HB2  1 
ATOM   3561 H HB3  . ASN A 1 238 ? -21.79031 -6.76136  17.50674  1.000 38.02672 ? 238 ASN A HB3  1 
ATOM   3562 H HD21 . ASN A 1 238 ? -20.47461 -3.94859  16.89478  1.000 58.19631 ? 238 ASN A HD21 1 
ATOM   3563 H HD22 . ASN A 1 238 ? -21.55270 -3.23429  16.15568  1.000 58.19631 ? 238 ASN A HD22 1 
ATOM   3564 N N    . TYR A 1 239 ? -22.28564 -7.04851  21.44010  1.000 20.82377 ? 239 TYR A N    1 
ATOM   3565 C CA   . TYR A 1 239 ? -22.18312 -8.12802  22.40447  1.000 23.34389 ? 239 TYR A CA   1 
ATOM   3566 C C    . TYR A 1 239 ? -23.55266 -8.76819  22.53359  1.000 24.25641 ? 239 TYR A C    1 
ATOM   3567 O O    . TYR A 1 239 ? -24.56421 -8.06698  22.50267  1.000 29.38367 ? 239 TYR A O    1 
ATOM   3568 C CB   . TYR A 1 239 ? -21.74503 -7.59051  23.76196  1.000 23.92891 ? 239 TYR A CB   1 
ATOM   3569 C CG   . TYR A 1 239 ? -20.27108 -7.60844  23.93747  1.000 17.75244 ? 239 TYR A CG   1 
ATOM   3570 C CD1  . TYR A 1 239 ? -19.42421 -7.03019  22.99912  1.000 21.92105 ? 239 TYR A CD1  1 
ATOM   3571 C CD2  . TYR A 1 239 ? -19.70498 -8.23068  25.04928  1.000 23.73745 ? 239 TYR A CD2  1 
ATOM   3572 C CE1  . TYR A 1 239 ? -18.06322 -7.08220  23.14657  1.000 26.03348 ? 239 TYR A CE1  1 
ATOM   3573 C CE2  . TYR A 1 239 ? -18.34099 -8.28169  25.20973  1.000 24.16958 ? 239 TYR A CE2  1 
ATOM   3574 C CZ   . TYR A 1 239 ? -17.53313 -7.69147  24.27038  1.000 23.82437 ? 239 TYR A CZ   1 
ATOM   3575 O OH   . TYR A 1 239 ? -16.17616 -7.72849  24.43684  1.000 22.32865 ? 239 TYR A OH   1 
ATOM   3576 H H    . TYR A 1 239 ? -22.65832 -6.35001  21.77440  1.000 24.98852 ? 239 TYR A H    1 
ATOM   3577 H HA   . TYR A 1 239 ? -21.53649 -8.79133  22.11729  1.000 28.01266 ? 239 TYR A HA   1 
ATOM   3578 H HB2  . TYR A 1 239 ? -22.04679 -6.67280  23.85042  1.000 28.71469 ? 239 TYR A HB2  1 
ATOM   3579 H HB3  . TYR A 1 239 ? -22.13784 -8.13725  24.46048  1.000 28.71469 ? 239 TYR A HB3  1 
ATOM   3580 H HD1  . TYR A 1 239 ? -19.78729 -6.60002  22.25926  1.000 26.30526 ? 239 TYR A HD1  1 
ATOM   3581 H HD2  . TYR A 1 239 ? -20.25790 -8.61651  25.68985  1.000 28.48494 ? 239 TYR A HD2  1 
ATOM   3582 H HE1  . TYR A 1 239 ? -17.50428 -6.71436  22.50099  1.000 31.24017 ? 239 TYR A HE1  1 
ATOM   3583 H HE2  . TYR A 1 239 ? -17.96991 -8.71085  25.94660  1.000 29.00349 ? 239 TYR A HE2  1 
ATOM   3584 H HH   . TYR A 1 239 ? -15.98715 -8.07180  25.17969  1.000 26.79438 ? 239 TYR A HH   1 
ATOM   3585 N N    . GLU A 1 240 ? -23.58867 -10.08331 22.68477  1.000 23.38202 ? 240 GLU A N    1 
ATOM   3586 C CA   . GLU A 1 240 ? -24.84619 -10.77445 22.89490  1.000 26.87259 ? 240 GLU A CA   1 
ATOM   3587 C C    . GLU A 1 240 ? -25.53407 -10.23177 24.15199  1.000 30.17417 ? 240 GLU A C    1 
ATOM   3588 O O    . GLU A 1 240 ? -24.85967 -9.91884  25.14642  1.000 29.04330 ? 240 GLU A O    1 
ATOM   3589 C CB   . GLU A 1 240 ? -24.58806 -12.26734 23.05907  1.000 34.11162 ? 240 GLU A CB   1 
ATOM   3590 C CG   . GLU A 1 240 ? -25.83585 -13.06240 23.25005  1.000 45.71752 ? 240 GLU A CG   1 
ATOM   3591 C CD   . GLU A 1 240 ? -25.56466 -14.50521 23.59256  1.000 54.11950 ? 240 GLU A CD   1 
ATOM   3592 O OE1  . GLU A 1 240 ? -24.40455 -14.96846 23.50198  1.000 48.73845 ? 240 GLU A OE1  1 
ATOM   3593 O OE2  . GLU A 1 240 ? -26.55725 -15.18673 23.94193  1.000 59.50854 ? 240 GLU A OE2  1 
ATOM   3594 H H    . GLU A 1 240 ? -22.89925 -10.59676 22.66969  1.000 28.05842 ? 240 GLU A H    1 
ATOM   3595 H HA   . GLU A 1 240 ? -25.43303 -10.63444 22.13478  1.000 32.24711 ? 240 GLU A HA   1 
ATOM   3596 H HB2  . GLU A 1 240 ? -24.14242 -12.59855 22.26369  1.000 40.93395 ? 240 GLU A HB2  1 
ATOM   3597 H HB3  . GLU A 1 240 ? -24.02425 -12.40420 23.83642  1.000 40.93395 ? 240 GLU A HB3  1 
ATOM   3598 H HG2  . GLU A 1 240 ? -26.34970 -12.67326 23.97598  1.000 54.86102 ? 240 GLU A HG2  1 
ATOM   3599 H HG3  . GLU A 1 240 ? -26.35223 -13.04112 22.43013  1.000 54.86102 ? 240 GLU A HG3  1 
ATOM   3600 N N    . PRO A 1 241 ? -26.86117 -10.10083 24.15560  1.000 29.36048 ? 241 PRO A N    1 
ATOM   3601 C CA   . PRO A 1 241 ? -27.53200 -9.60811  25.37467  1.000 32.55426 ? 241 PRO A CA   1 
ATOM   3602 C C    . PRO A 1 241 ? -27.37163 -10.58070 26.53413  1.000 24.81992 ? 241 PRO A C    1 
ATOM   3603 O O    . PRO A 1 241 ? -27.44160 -11.79865 26.35635  1.000 27.48263 ? 241 PRO A O    1 
ATOM   3604 C CB   . PRO A 1 241 ? -29.00096 -9.46702  24.95024  1.000 36.88403 ? 241 PRO A CB   1 
ATOM   3605 C CG   . PRO A 1 241 ? -28.95252 -9.34604  23.42033  1.000 31.36922 ? 241 PRO A CG   1 
ATOM   3606 C CD   . PRO A 1 241 ? -27.78767 -10.22886 23.01520  1.000 29.60340 ? 241 PRO A CD   1 
ATOM   3607 H HA   . PRO A 1 241 ? -27.18078 -8.73999  25.62733  1.000 39.06511 ? 241 PRO A HA   1 
ATOM   3608 H HB2  . PRO A 1 241 ? -29.50143 -10.25159 25.22158  1.000 44.26084 ? 241 PRO A HB2  1 
ATOM   3609 H HB3  . PRO A 1 241 ? -29.38673 -8.67257  25.35059  1.000 44.26084 ? 241 PRO A HB3  1 
ATOM   3610 H HG2  . PRO A 1 241 ? -29.78313 -9.66346  23.03284  1.000 37.64306 ? 241 PRO A HG2  1 
ATOM   3611 H HG3  . PRO A 1 241 ? -28.79716 -8.42376  23.16295  1.000 37.64306 ? 241 PRO A HG3  1 
ATOM   3612 H HD2  . PRO A 1 241 ? -28.07390 -11.14902 22.90253  1.000 35.52408 ? 241 PRO A HD2  1 
ATOM   3613 H HD3  . PRO A 1 241 ? -27.37664 -9.90703  22.19654  1.000 35.52408 ? 241 PRO A HD3  1 
ATOM   3614 N N    . LEU A 1 242 ? -27.18249 -10.03929 27.74053  1.000 28.20631 ? 242 LEU A N    1 
ATOM   3615 C CA   . LEU A 1 242 ? -27.02721 -10.90488 28.89305  1.000 27.56730 ? 242 LEU A CA   1 
ATOM   3616 C C    . LEU A 1 242 ? -28.40421 -11.17335 29.50340  1.000 30.49399 ? 242 LEU A C    1 
ATOM   3617 O O    . LEU A 1 242 ? -29.20902 -10.24611 29.69469  1.000 28.80916 ? 242 LEU A O    1 
ATOM   3618 C CB   . LEU A 1 242 ? -26.11907 -10.29381 29.94875  1.000 28.77771 ? 242 LEU A CB   1 
ATOM   3619 C CG   . LEU A 1 242 ? -25.40851 -11.36276 30.79334  1.000 31.50907 ? 242 LEU A CG   1 
ATOM   3620 C CD1  . LEU A 1 242 ? -24.27870 -12.04840 30.03831  1.000 29.79655 ? 242 LEU A CD1  1 
ATOM   3621 C CD2  . LEU A 1 242 ? -24.92252 -10.65114 32.02795  1.000 30.90842 ? 242 LEU A CD2  1 
ATOM   3622 H H    . LEU A 1 242 ? -27.14322 -9.19536  27.90406  1.000 33.84757 ? 242 LEU A H    1 
ATOM   3623 H HA   . LEU A 1 242 ? -26.62144 -11.73738 28.60368  1.000 33.08075 ? 242 LEU A HA   1 
ATOM   3624 H HB2  . LEU A 1 242 ? -25.44234 -9.75400  29.51132  1.000 34.53325 ? 242 LEU A HB2  1 
ATOM   3625 H HB3  . LEU A 1 242 ? -26.65072 -9.74160  30.54290  1.000 34.53325 ? 242 LEU A HB3  1 
ATOM   3626 H HG   . LEU A 1 242 ? -26.00802 -12.08938 31.02568  1.000 37.81089 ? 242 LEU A HG   1 
ATOM   3627 H HD11 . LEU A 1 242 ? -23.70356 -12.50333 30.67324  1.000 35.75586 ? 242 LEU A HD11 1 
ATOM   3628 H HD12 . LEU A 1 242 ? -24.65797 -12.69032 29.41679  1.000 35.75586 ? 242 LEU A HD12 1 
ATOM   3629 H HD13 . LEU A 1 242 ? -23.77106 -11.37969 29.55291  1.000 35.75586 ? 242 LEU A HD13 1 
ATOM   3630 H HD21 . LEU A 1 242 ? -24.47721 -11.28914 32.60571  1.000 37.09010 ? 242 LEU A HD21 1 
ATOM   3631 H HD22 . LEU A 1 242 ? -24.30298 -9.95248  31.76560  1.000 37.09010 ? 242 LEU A HD22 1 
ATOM   3632 H HD23 . LEU A 1 242 ? -25.68299 -10.26202 32.48792  1.000 37.09010 ? 242 LEU A HD23 1 
ATOM   3633 N N    . THR A 1 243 ? -28.66331 -12.43875 29.81153  1.000 24.56954 ? 243 THR A N    1 
ATOM   3634 C CA   . THR A 1 243 ? -29.90316 -12.90111 30.41680  1.000 25.65432 ? 243 THR A CA   1 
ATOM   3635 C C    . THR A 1 243 ? -29.60621 -13.45473 31.80357  1.000 27.92977 ? 243 THR A C    1 
ATOM   3636 O O    . THR A 1 243 ? -28.44622 -13.62405 32.20587  1.000 24.61575 ? 243 THR A O    1 
ATOM   3637 C CB   . THR A 1 243 ? -30.54499 -14.00611 29.59290  1.000 24.37105 ? 243 THR A CB   1 
ATOM   3638 O OG1  . THR A 1 243 ? -29.74210 -15.18055 29.71946  1.000 28.71379 ? 243 THR A OG1  1 
ATOM   3639 C CG2  . THR A 1 243 ? -30.65377 -13.63230 28.13109  1.000 28.69152 ? 243 THR A CG2  1 
ATOM   3640 H H    . THR A 1 243 ? -28.10675 -13.07922 29.67233  1.000 29.48345 ? 243 THR A H    1 
ATOM   3641 H HA   . THR A 1 243 ? -30.51777 -12.15263 30.47205  1.000 30.78518 ? 243 THR A HA   1 
ATOM   3642 H HB   . THR A 1 243 ? -31.44598 -14.16503 29.91348  1.000 29.24526 ? 243 THR A HB   1 
ATOM   3643 H HG1  . THR A 1 243 ? -30.16447 -15.84971 29.43589  1.000 34.45655 ? 243 THR A HG1  1 
ATOM   3644 H HG21 . THR A 1 243 ? -31.25412 -14.24350 27.67650  1.000 34.42982 ? 243 THR A HG21 1 
ATOM   3645 H HG22 . THR A 1 243 ? -30.99846 -12.72952 28.04452  1.000 34.42982 ? 243 THR A HG22 1 
ATOM   3646 H HG23 . THR A 1 243 ? -29.78059 -13.67734 27.71137  1.000 34.42982 ? 243 THR A HG23 1 
ATOM   3647 N N    . GLN A 1 244 ? -30.68219 -13.79203 32.51898  1.000 26.48135 ? 244 GLN A N    1 
ATOM   3648 C CA   . GLN A 1 244 ? -30.53521 -14.36573 33.84768  1.000 25.05655 ? 244 GLN A CA   1 
ATOM   3649 C C    . GLN A 1 244 ? -30.00405 -15.79127 33.79799  1.000 22.80435 ? 244 GLN A C    1 
ATOM   3650 O O    . GLN A 1 244 ? -29.33603 -16.24132 34.73495  1.000 27.14539 ? 244 GLN A O    1 
ATOM   3651 C CB   . GLN A 1 244 ? -31.88950 -14.31725 34.56323  1.000 29.90409 ? 244 GLN A CB   1 
ATOM   3652 C CG   . GLN A 1 244 ? -31.86161 -14.81210 35.98894  1.000 27.33985 ? 244 GLN A CG   1 
ATOM   3653 C CD   . GLN A 1 244 ? -31.05364 -13.90600 36.87178  1.000 30.71589 ? 244 GLN A CD   1 
ATOM   3654 O OE1  . GLN A 1 244 ? -31.16559 -12.68005 36.80650  1.000 28.10031 ? 244 GLN A OE1  1 
ATOM   3655 N NE2  . GLN A 1 244 ? -30.22946 -14.50988 37.73270  1.000 31.32738 ? 244 GLN A NE2  1 
ATOM   3656 H H    . GLN A 1 244 ? -31.49617 -13.69951 32.25675  1.000 31.77762 ? 244 GLN A H    1 
ATOM   3657 H HA   . GLN A 1 244 ? -29.89680 -13.84153 34.35623  1.000 30.06786 ? 244 GLN A HA   1 
ATOM   3658 H HB2  . GLN A 1 244 ? -32.19824 -13.39750 34.57769  1.000 35.88491 ? 244 GLN A HB2  1 
ATOM   3659 H HB3  . GLN A 1 244 ? -32.51788 -14.87044 34.07267  1.000 35.88491 ? 244 GLN A HB3  1 
ATOM   3660 H HG2  . GLN A 1 244 ? -32.76770 -14.84604 36.33360  1.000 32.80782 ? 244 GLN A HG2  1 
ATOM   3661 H HG3  . GLN A 1 244 ? -31.46391 -15.69580 36.01353  1.000 32.80782 ? 244 GLN A HG3  1 
ATOM   3662 H HE21 . GLN A 1 244 ? -30.18579 -15.36786 37.75719  1.000 37.59285 ? 244 GLN A HE21 1 
ATOM   3663 H HE22 . GLN A 1 244 ? -29.74303 -14.03882 38.26316  1.000 37.59285 ? 244 GLN A HE22 1 
ATOM   3664 N N    . ASP A 1 245 ? -30.29710 -16.52185 32.73543  1.000 29.51520 ? 245 ASP A N    1 
ATOM   3665 C CA   . ASP A 1 245 ? -29.65900 -17.82124 32.56286  1.000 26.08154 ? 245 ASP A CA   1 
ATOM   3666 C C    . ASP A 1 245 ? -28.14611 -17.69104 32.57247  1.000 21.15016 ? 245 ASP A C    1 
ATOM   3667 O O    . ASP A 1 245 ? -27.45771 -18.47989 33.21523  1.000 28.18552 ? 245 ASP A O    1 
ATOM   3668 C CB   . ASP A 1 245 ? -30.08804 -18.45278 31.25732  1.000 24.46826 ? 245 ASP A CB   1 
ATOM   3669 C CG   . ASP A 1 245 ? -31.45860 -19.03191 31.31648  1.000 34.91027 ? 245 ASP A CG   1 
ATOM   3670 O OD1  . ASP A 1 245 ? -31.86263 -19.47490 32.40406  1.000 42.11130 ? 245 ASP A OD1  1 
ATOM   3671 O OD2  . ASP A 1 245 ? -32.14024 -19.01180 30.26125  1.000 43.35149 ? 245 ASP A OD2  1 
ATOM   3672 H H    . ASP A 1 245 ? -30.84706 -16.29791 32.11338  1.000 35.41824 ? 245 ASP A H    1 
ATOM   3673 H HA   . ASP A 1 245 ? -29.93880 -18.39291 33.29441  1.000 31.29785 ? 245 ASP A HA   1 
ATOM   3674 H HB2  . ASP A 1 245 ? -30.07733 -17.77634 30.56174  1.000 29.36191 ? 245 ASP A HB2  1 
ATOM   3675 H HB3  . ASP A 1 245 ? -29.47039 -19.16715 31.03509  1.000 29.36191 ? 245 ASP A HB3  1 
ATOM   3676 N N    . HIS A 1 246 ? -27.61765 -16.69418 31.86427  1.000 23.33960 ? 246 HIS A N    1 
ATOM   3677 C CA   . HIS A 1 246 ? -26.17883 -16.46103 31.85392  1.000 25.72300 ? 246 HIS A CA   1 
ATOM   3678 C C    . HIS A 1 246 ? -25.69061 -16.09450 33.24332  1.000 24.67947 ? 246 HIS A C    1 
ATOM   3679 O O    . HIS A 1 246 ? -24.64039 -16.56994 33.69340  1.000 23.00056 ? 246 HIS A O    1 
ATOM   3680 C CB   . HIS A 1 246 ? -25.82641 -15.31817 30.91275  1.000 19.94208 ? 246 HIS A CB   1 
ATOM   3681 C CG   . HIS A 1 246 ? -26.16970 -15.58057 29.49447  1.000 26.94685 ? 246 HIS A CG   1 
ATOM   3682 N ND1  . HIS A 1 246 ? -26.56520 -14.57236 28.64595  1.000 29.89510 ? 246 HIS A ND1  1 
ATOM   3683 C CD2  . HIS A 1 246 ? -26.20153 -16.72515 28.77475  1.000 29.17010 ? 246 HIS A CD2  1 
ATOM   3684 C CE1  . HIS A 1 246 ? -26.84437 -15.09085 27.46253  1.000 26.53512 ? 246 HIS A CE1  1 
ATOM   3685 N NE2  . HIS A 1 246 ? -26.62635 -16.39271 27.51181  1.000 30.75405 ? 246 HIS A NE2  1 
ATOM   3686 H H    . HIS A 1 246 ? -28.06892 -16.14125 31.38345  1.000 28.00751 ? 246 HIS A H    1 
ATOM   3687 H HA   . HIS A 1 246 ? -25.74708 -17.27250 31.54658  1.000 30.86759 ? 246 HIS A HA   1 
ATOM   3688 H HB2  . HIS A 1 246 ? -26.30914 -14.52473 31.19207  1.000 23.93049 ? 246 HIS A HB2  1 
ATOM   3689 H HB3  . HIS A 1 246 ? -24.87055 -15.15944 30.96019  1.000 23.93049 ? 246 HIS A HB3  1 
ATOM   3690 H HD2  . HIS A 1 246 ? -25.97896 -17.57616 29.07731  1.000 35.00412 ? 246 HIS A HD2  1 
ATOM   3691 H HE1  . HIS A 1 246 ? -27.14348 -14.61863 26.71972  1.000 31.84214 ? 246 HIS A HE1  1 
ATOM   3692 H HE2  . HIS A 1 246 ? -26.73268 -16.94239 26.85943  1.000 36.90485 ? 246 HIS A HE2  1 
ATOM   3693 N N    . VAL A 1 247 ? -26.41357 -15.18448 33.90863  1.000 23.90849 ? 247 VAL A N    1 
ATOM   3694 C CA   . VAL A 1 247 ? -26.06935 -14.81806 35.28698  1.000 23.58889 ? 247 VAL A CA   1 
ATOM   3695 C C    . VAL A 1 247 ? -25.99466 -16.06953 36.14823  1.000 22.33676 ? 247 VAL A C    1 
ATOM   3696 O O    . VAL A 1 247 ? -25.04878 -16.25525 36.91845  1.000 22.03332 ? 247 VAL A O    1 
ATOM   3697 C CB   . VAL A 1 247 ? -27.07337 -13.79921 35.85625  1.000 22.65582 ? 247 VAL A CB   1 
ATOM   3698 C CG1  . VAL A 1 247 ? -26.71011 -13.50982 37.31556  1.000 22.51897 ? 247 VAL A CG1  1 
ATOM   3699 C CG2  . VAL A 1 247 ? -27.06310 -12.51470 35.04905  1.000 26.25353 ? 247 VAL A CG2  1 
ATOM   3700 H H    . VAL A 1 247 ? -27.09779 -14.77183 33.58864  1.000 28.69019 ? 247 VAL A H    1 
ATOM   3701 H HA   . VAL A 1 247 ? -25.19669 -14.39336 35.28455  1.000 28.30667 ? 247 VAL A HA   1 
ATOM   3702 H HB   . VAL A 1 247 ? -27.96906 -14.16789 35.80871  1.000 27.18699 ? 247 VAL A HB   1 
ATOM   3703 H HG11 . VAL A 1 247 ? -27.11487 -12.66930 37.57993  1.000 27.02276 ? 247 VAL A HG11 1 
ATOM   3704 H HG12 . VAL A 1 247 ? -27.04474 -14.22843 37.87300  1.000 27.02276 ? 247 VAL A HG12 1 
ATOM   3705 H HG13 . VAL A 1 247 ? -25.74519 -13.45110 37.39493  1.000 27.02276 ? 247 VAL A HG13 1 
ATOM   3706 H HG21 . VAL A 1 247 ? -27.75269 -11.92346 35.38917  1.000 31.50424 ? 247 VAL A HG21 1 
ATOM   3707 H HG22 . VAL A 1 247 ? -26.19447 -12.09306 35.13561  1.000 31.50424 ? 247 VAL A HG22 1 
ATOM   3708 H HG23 . VAL A 1 247 ? -27.23761 -12.72527 34.11785  1.000 31.50424 ? 247 VAL A HG23 1 
ATOM   3709 N N    . ASP A 1 248 ? -26.98591 -16.94924 36.01734  1.000 24.70728 ? 248 ASP A N    1 
ATOM   3710 C CA   . ASP A 1 248 ? -27.02023 -18.16776 36.81858  1.000 26.29410 ? 248 ASP A CA   1 
ATOM   3711 C C    . ASP A 1 248 ? -25.81243 -19.04463 36.53646  1.000 31.04264 ? 248 ASP A C    1 
ATOM   3712 O O    . ASP A 1 248 ? -25.23928 -19.64374 37.45329  1.000 25.56961 ? 248 ASP A O    1 
ATOM   3713 C CB   . ASP A 1 248 ? -28.29350 -18.96662 36.55963  1.000 24.60719 ? 248 ASP A CB   1 
ATOM   3714 C CG   . ASP A 1 248 ? -29.53023 -18.32097 37.15360  1.000 32.69174 ? 248 ASP A CG   1 
ATOM   3715 O OD1  . ASP A 1 248 ? -29.39927 -17.35434 37.93524  1.000 26.77619 ? 248 ASP A OD1  1 
ATOM   3716 O OD2  . ASP A 1 248 ? -30.64373 -18.79865 36.82791  1.000 30.70286 ? 248 ASP A OD2  1 
ATOM   3717 H H    . ASP A 1 248 ? -27.64779 -16.86443 35.47516  1.000 29.64874 ? 248 ASP A H    1 
ATOM   3718 H HA   . ASP A 1 248 ? -27.01577 -17.90333 37.75174  1.000 31.55292 ? 248 ASP A HA   1 
ATOM   3719 H HB2  . ASP A 1 248 ? -28.42810 -19.04313 35.60254  1.000 29.52863 ? 248 ASP A HB2  1 
ATOM   3720 H HB3  . ASP A 1 248 ? -28.19794 -19.84778 36.95412  1.000 29.52863 ? 248 ASP A HB3  1 
ATOM   3721 N N    . ILE A 1 249 ? -25.40990 -19.14252 35.26654  1.000 23.93490 ? 249 ILE A N    1 
ATOM   3722 C CA   . ILE A 1 249 ? -24.28309 -20.00241 34.91041  1.000 25.56904 ? 249 ILE A CA   1 
ATOM   3723 C C    . ILE A 1 249 ? -22.99572 -19.47574 35.49419  1.000 24.37815 ? 249 ILE A C    1 
ATOM   3724 O O    . ILE A 1 249 ? -22.06219 -20.25016 35.75004  1.000 30.65692 ? 249 ILE A O    1 
ATOM   3725 C CB   . ILE A 1 249 ? -24.17945 -20.13338 33.37637  1.000 21.78697 ? 249 ILE A CB   1 
ATOM   3726 C CG1  . ILE A 1 249 ? -25.48581 -20.70911 32.88055  1.000 24.64115 ? 249 ILE A CG1  1 
ATOM   3727 C CG2  . ILE A 1 249 ? -22.94967 -20.95418 33.02429  1.000 35.02241 ? 249 ILE A CG2  1 
ATOM   3728 C CD1  . ILE A 1 249 ? -25.59429 -20.72130 31.41550  1.000 34.15339 ? 249 ILE A CD1  1 
ATOM   3729 H H    . ILE A 1 249 ? -25.76700 -18.72740 34.60367  1.000 28.72188 ? 249 ILE A H    1 
ATOM   3730 H HA   . ILE A 1 249 ? -24.44552 -20.88277 35.28481  1.000 30.68284 ? 249 ILE A HA   1 
ATOM   3731 H HB   . ILE A 1 249 ? -24.05497 -19.27901 32.93594  1.000 26.14436 ? 249 ILE A HB   1 
ATOM   3732 H HG12 . ILE A 1 249 ? -25.56420 -21.62337 33.19296  1.000 29.56938 ? 249 ILE A HG12 1 
ATOM   3733 H HG13 . ILE A 1 249 ? -26.21636 -20.17491 33.22962  1.000 29.56938 ? 249 ILE A HG13 1 
ATOM   3734 H HG21 . ILE A 1 249 ? -22.96517 -21.15461 32.07616  1.000 42.02689 ? 249 ILE A HG21 1 
ATOM   3735 H HG22 . ILE A 1 249 ? -22.15515 -20.44169 33.24189  1.000 42.02689 ? 249 ILE A HG22 1 
ATOM   3736 H HG23 . ILE A 1 249 ? -22.96219 -21.77751 33.53678  1.000 42.02689 ? 249 ILE A HG23 1 
ATOM   3737 H HD11 . ILE A 1 249 ? -26.50301 -20.95587 31.16804  1.000 40.98407 ? 249 ILE A HD11 1 
ATOM   3738 H HD12 . ILE A 1 249 ? -25.37687 -19.83891 31.07512  1.000 40.98407 ? 249 ILE A HD12 1 
ATOM   3739 H HD13 . ILE A 1 249 ? -24.97464 -21.37558 31.05732  1.000 40.98407 ? 249 ILE A HD13 1 
ATOM   3740 N N    . LEU A 1 250 ? -22.90783 -18.16980 35.69603  1.000 23.15056 ? 250 LEU A N    1 
ATOM   3741 C CA   . LEU A 1 250 ? -21.70651 -17.56619 36.25782  1.000 19.25667 ? 250 LEU A CA   1 
ATOM   3742 C C    . LEU A 1 250 ? -21.68298 -17.65010 37.77678  1.000 19.26421 ? 250 LEU A C    1 
ATOM   3743 O O    . LEU A 1 250 ? -20.72457 -17.17472 38.38741  1.000 28.95825 ? 250 LEU A O    1 
ATOM   3744 C CB   . LEU A 1 250 ? -21.57453 -16.10083 35.84577  1.000 23.74452 ? 250 LEU A CB   1 
ATOM   3745 C CG   . LEU A 1 250 ? -21.35621 -15.83873 34.35201  1.000 22.43289 ? 250 LEU A CG   1 
ATOM   3746 C CD1  . LEU A 1 250 ? -21.48118 -14.42555 33.90484  1.000 21.77394 ? 250 LEU A CD1  1 
ATOM   3747 C CD2  . LEU A 1 250 ? -19.92867 -16.36839 34.02719  1.000 17.06414 ? 250 LEU A CD2  1 
ATOM   3748 H H    . LEU A 1 250 ? -23.53321 -17.60718 35.51515  1.000 27.78067 ? 250 LEU A H    1 
ATOM   3749 H HA   . LEU A 1 250 ? -20.93900 -18.03735 35.89680  1.000 23.10801 ? 250 LEU A HA   1 
ATOM   3750 H HB2  . LEU A 1 250 ? -22.38798 -15.64063 36.10277  1.000 28.49342 ? 250 LEU A HB2  1 
ATOM   3751 H HB3  . LEU A 1 250 ? -20.81600 -15.72151 36.31727  1.000 28.49342 ? 250 LEU A HB3  1 
ATOM   3752 H HG   . LEU A 1 250 ? -22.06468 -16.28699 33.86348  1.000 26.91947 ? 250 LEU A HG   1 
ATOM   3753 H HD11 . LEU A 1 250 ? -21.22089 -14.36477 32.97197  1.000 26.12873 ? 250 LEU A HD11 1 
ATOM   3754 H HD12 . LEU A 1 250 ? -22.40144 -14.14035 34.01069  1.000 26.12873 ? 250 LEU A HD12 1 
ATOM   3755 H HD13 . LEU A 1 250 ? -20.89781 -13.87042 34.44639  1.000 26.12873 ? 250 LEU A HD13 1 
ATOM   3756 H HD21 . LEU A 1 250 ? -19.73447 -16.20066 33.09136  1.000 20.47697 ? 250 LEU A HD21 1 
ATOM   3757 H HD22 . LEU A 1 250 ? -19.28524 -15.90523 34.58670  1.000 20.47697 ? 250 LEU A HD22 1 
ATOM   3758 H HD23 . LEU A 1 250 ? -19.89698 -17.32048 34.20661  1.000 20.47697 ? 250 LEU A HD23 1 
ATOM   3759 N N    . GLY A 1 251 ? -22.73276 -18.19031 38.37808  1.000 22.81348 ? 251 GLY A N    1 
ATOM   3760 C CA   . GLY A 1 251 ? -22.88324 -18.22131 39.81300  1.000 22.21828 ? 251 GLY A CA   1 
ATOM   3761 C C    . GLY A 1 251 ? -21.69006 -18.78282 40.55108  1.000 28.96690 ? 251 GLY A C    1 
ATOM   3762 O O    . GLY A 1 251 ? -21.13289 -18.13292 41.43868  1.000 24.21715 ? 251 GLY A O    1 
ATOM   3763 H H    . GLY A 1 251 ? -23.38932 -18.55557 37.95862  1.000 27.37618 ? 251 GLY A H    1 
ATOM   3764 H HA2  . GLY A 1 251 ? -23.03207 -17.31763 40.13251  1.000 26.66194 ? 251 GLY A HA2  1 
ATOM   3765 H HA3  . GLY A 1 251 ? -23.65389 -18.76607 40.03640  1.000 26.66194 ? 251 GLY A HA3  1 
ATOM   3766 N N    . PRO A 1 252 ? -21.30796 -20.02132 40.23245  1.000 27.82718 ? 252 PRO A N    1 
ATOM   3767 C CA   . PRO A 1 252 ? -20.12271 -20.61678 40.88950  1.000 30.62511 ? 252 PRO A CA   1 
ATOM   3768 C C    . PRO A 1 252 ? -18.87638 -19.74574 40.81248  1.000 27.05171 ? 252 PRO A C    1 
ATOM   3769 O O    . PRO A 1 252 ? -18.09879 -19.65972 41.78881  1.000 25.97284 ? 252 PRO A O    1 
ATOM   3770 C CB   . PRO A 1 252 ? -19.95240 -21.93217 40.12075  1.000 34.53120 ? 252 PRO A CB   1 
ATOM   3771 C CG   . PRO A 1 252 ? -21.40096 -22.32010 39.75600  1.000 33.96137 ? 252 PRO A CG   1 
ATOM   3772 C CD   . PRO A 1 252 ? -22.05989 -20.99341 39.41358  1.000 29.42710 ? 252 PRO A CD   1 
ATOM   3773 H HA   . PRO A 1 252 ? -20.31590 -20.80151 41.82132  1.000 36.75013 ? 252 PRO A HA   1 
ATOM   3774 H HB2  . PRO A 1 252 ? -19.41323 -21.79125 39.32603  1.000 41.43744 ? 252 PRO A HB2  1 
ATOM   3775 H HB3  . PRO A 1 252 ? -19.53906 -22.60219 40.68648  1.000 41.43744 ? 252 PRO A HB3  1 
ATOM   3776 H HG2  . PRO A 1 252 ? -21.40621 -22.92063 38.99363  1.000 40.75365 ? 252 PRO A HG2  1 
ATOM   3777 H HG3  . PRO A 1 252 ? -21.83589 -22.74191 40.51359  1.000 40.75365 ? 252 PRO A HG3  1 
ATOM   3778 H HD2  . PRO A 1 252 ? -21.96672 -20.79576 38.46874  1.000 35.31252 ? 252 PRO A HD2  1 
ATOM   3779 H HD3  . PRO A 1 252 ? -22.99798 -21.00031 39.66025  1.000 35.31252 ? 252 PRO A HD3  1 
ATOM   3780 N N    . LEU A 1 253 ? -18.64650 -19.09085 39.66996  1.000 23.74810 ? 253 LEU A N    1 
ATOM   3781 C CA   . LEU A 1 253 ? -17.47415 -18.22786 39.57391  1.000 25.40079 ? 253 LEU A CA   1 
ATOM   3782 C C    . LEU A 1 253 ? -17.64945 -16.96851 40.40162  1.000 26.69906 ? 253 LEU A C    1 
ATOM   3783 O O    . LEU A 1 253 ? -16.67706 -16.44408 40.96129  1.000 30.05874 ? 253 LEU A O    1 
ATOM   3784 C CB   . LEU A 1 253 ? -17.20096 -17.82075 38.12626  1.000 20.96216 ? 253 LEU A CB   1 
ATOM   3785 C CG   . LEU A 1 253 ? -16.71977 -18.88676 37.14277  1.000 28.91598 ? 253 LEU A CG   1 
ATOM   3786 C CD1  . LEU A 1 253 ? -16.68470 -18.33485 35.71112  1.000 23.79343 ? 253 LEU A CD1  1 
ATOM   3787 C CD2  . LEU A 1 253 ? -15.37246 -19.44594 37.54290  1.000 24.83051 ? 253 LEU A CD2  1 
ATOM   3788 H H    . LEU A 1 253 ? -19.13622 -19.12981 38.96377  1.000 28.49773 ? 253 LEU A H    1 
ATOM   3789 H HA   . LEU A 1 253 ? -16.71586 -18.73646 39.90186  1.000 30.48094 ? 253 LEU A HA   1 
ATOM   3790 H HB2  . LEU A 1 253 ? -18.02612 -17.46318 37.76318  1.000 25.15460 ? 253 LEU A HB2  1 
ATOM   3791 H HB3  . LEU A 1 253 ? -16.51852 -17.13121 38.14092  1.000 25.15460 ? 253 LEU A HB3  1 
ATOM   3792 H HG   . LEU A 1 253 ? -17.35019 -19.62328 37.16209  1.000 34.69917 ? 253 LEU A HG   1 
ATOM   3793 H HD11 . LEU A 1 253 ? -16.46291 -19.05430 35.09975  1.000 28.55211 ? 253 LEU A HD11 1 
ATOM   3794 H HD12 . LEU A 1 253 ? -17.55691 -17.97141 35.49104  1.000 28.55211 ? 253 LEU A HD12 1 
ATOM   3795 H HD13 . LEU A 1 253 ? -16.01324 -17.63628 35.65779  1.000 28.55211 ? 253 LEU A HD13 1 
ATOM   3796 H HD21 . LEU A 1 253 ? -15.07373 -20.06928 36.86262  1.000 29.79662 ? 253 LEU A HD21 1 
ATOM   3797 H HD22 . LEU A 1 253 ? -14.73807 -18.71648 37.62357  1.000 29.79662 ? 253 LEU A HD22 1 
ATOM   3798 H HD23 . LEU A 1 253 ? -15.46040 -19.90353 38.39459  1.000 29.79662 ? 253 LEU A HD23 1 
ATOM   3799 N N    . SER A 1 254 ? -18.87189 -16.42250 40.43653  1.000 25.90371 ? 254 SER A N    1 
ATOM   3800 C CA   A SER A 1 254 ? -19.17408 -15.34431 41.36409  0.710 26.53382 ? 254 SER A CA   1 
ATOM   3801 C CA   B SER A 1 254 ? -19.15808 -15.33930 41.36710  0.290 26.42225 ? 254 SER A CA   1 
ATOM   3802 C C    . SER A 1 254 ? -18.91424 -15.78600 42.80691  1.000 31.45890 ? 254 SER A C    1 
ATOM   3803 O O    . SER A 1 254 ? -18.30810 -15.05300 43.58957  1.000 29.94838 ? 254 SER A O    1 
ATOM   3804 C CB   A SER A 1 254 ? -20.62636 -14.90735 41.17184  0.710 28.33730 ? 254 SER A CB   1 
ATOM   3805 C CB   B SER A 1 254 ? -20.59442 -14.83833 41.17890  0.290 28.41189 ? 254 SER A CB   1 
ATOM   3806 O OG   A SER A 1 254 ? -20.99847 -13.93624 42.12431  0.710 32.42030 ? 254 SER A OG   1 
ATOM   3807 O OG   B SER A 1 254 ? -21.54686 -15.75640 41.68300  0.290 24.74839 ? 254 SER A OG   1 
ATOM   3808 H H    A SER A 1 254 ? -19.53053 -16.65972 39.93715  0.710 31.08445 ? 254 SER A H    1 
ATOM   3809 H H    B SER A 1 254 ? -19.53353 -16.65972 39.94115  0.290 31.08445 ? 254 SER A H    1 
ATOM   3810 H HA   A SER A 1 254 ? -18.60462 -14.58075 41.18076  0.710 31.84058 ? 254 SER A HA   1 
ATOM   3811 H HA   B SER A 1 254 ? -18.56761 -14.59272 41.17776  0.290 31.70670 ? 254 SER A HA   1 
ATOM   3812 H HB2  A SER A 1 254 ? -20.72535 -14.52988 40.28404  0.710 34.00475 ? 254 SER A HB2  1 
ATOM   3813 H HB2  B SER A 1 254 ? -20.69425 -13.99670 41.65038  0.290 34.09427 ? 254 SER A HB2  1 
ATOM   3814 H HB3  A SER A 1 254 ? -21.20278 -15.68087 41.27016  0.710 34.00475 ? 254 SER A HB3  1 
ATOM   3815 H HB3  B SER A 1 254 ? -20.75718 -14.70988 40.23192  0.290 34.09427 ? 254 SER A HB3  1 
ATOM   3816 H HG   A SER A 1 254 ? -20.58699 -13.21882 41.97890  0.710 38.90436 ? 254 SER A HG   1 
ATOM   3817 H HG   B SER A 1 254 ? -21.49014 -16.48510 41.26857  0.290 29.69807 ? 254 SER A HG   1 
ATOM   3818 N N    . ALA A 1 255 ? -19.32639 -17.01054 43.16101  1.000 23.68329 ? 255 ALA A N    1 
ATOM   3819 C CA   . ALA A 1 255 ? -19.12250 -17.48223 44.53279  1.000 27.22337 ? 255 ALA A CA   1 
ATOM   3820 C C    . ALA A 1 255 ? -17.63450 -17.62925 44.87022  1.000 37.52728 ? 255 ALA A C    1 
ATOM   3821 O O    . ALA A 1 255 ? -17.17425 -17.15153 45.91968  1.000 36.66205 ? 255 ALA A O    1 
ATOM   3822 C CB   . ALA A 1 255 ? -19.85752 -18.79594 44.74072  1.000 25.52284 ? 255 ALA A CB   1 
ATOM   3823 H H    . ALA A 1 255 ? -19.71676 -17.57153 42.63852  1.000 28.41995 ? 255 ALA A H    1 
ATOM   3824 H HA   . ALA A 1 255 ? -19.49324 -16.82590 45.14306  1.000 32.66805 ? 255 ALA A HA   1 
ATOM   3825 H HB1  . ALA A 1 255 ? -19.75763 -19.07143 45.66558  1.000 30.62740 ? 255 ALA A HB1  1 
ATOM   3826 H HB2  . ALA A 1 255 ? -20.79655 -18.66856 44.53347  1.000 30.62740 ? 255 ALA A HB2  1 
ATOM   3827 H HB3  . ALA A 1 255 ? -19.47678 -19.46728 44.15344  1.000 30.62740 ? 255 ALA A HB3  1 
ATOM   3828 N N    . GLN A 1 256 ? -16.86465 -18.30911 44.00807  1.000 37.14060 ? 256 GLN A N    1 
ATOM   3829 C CA   . GLN A 1 256 ? -15.43160 -18.48613 44.27247  1.000 32.71047 ? 256 GLN A CA   1 
ATOM   3830 C C    . GLN A 1 256 ? -14.75075 -17.14273 44.50254  1.000 33.68768 ? 256 GLN A C    1 
ATOM   3831 O O    . GLN A 1 256 ? -13.91719 -16.99963 45.41292  1.000 42.72237 ? 256 GLN A O    1 
ATOM   3832 C CB   . GLN A 1 256 ? -14.77161 -19.21988 43.10325  1.000 33.14596 ? 256 GLN A CB   1 
ATOM   3833 C CG   . GLN A 1 256 ? -13.28537 -19.59381 43.28055  1.000 38.57704 ? 256 GLN A CG   1 
ATOM   3834 C CD   . GLN A 1 256 ? -12.76825 -20.50671 42.15716  1.000 43.57641 ? 256 GLN A CD   1 
ATOM   3835 O OE1  . GLN A 1 256 ? -13.52957 -20.98179 41.31360  1.000 43.86282 ? 256 GLN A OE1  1 
ATOM   3836 N NE2  . GLN A 1 256 ? -11.47004 -20.76167 42.15847  1.000 38.78800 ? 256 GLN A NE2  1 
ATOM   3837 H H    . GLN A 1 256 ? -17.14211 -18.67088 43.27875  1.000 44.56872 ? 256 GLN A H    1 
ATOM   3838 H HA   . GLN A 1 256 ? -15.32246 -19.02653 45.07118  1.000 39.25256 ? 256 GLN A HA   1 
ATOM   3839 H HB2  . GLN A 1 256 ? -15.25690 -20.04618 42.95257  1.000 39.77515 ? 256 GLN A HB2  1 
ATOM   3840 H HB3  . GLN A 1 256 ? -14.83078 -18.65345 42.31858  1.000 39.77515 ? 256 GLN A HB3  1 
ATOM   3841 H HG2  . GLN A 1 256 ? -12.75202 -18.78338 43.27923  1.000 46.29245 ? 256 GLN A HG2  1 
ATOM   3842 H HG3  . GLN A 1 256 ? -13.17430 -20.06124 44.12330  1.000 46.29245 ? 256 GLN A HG3  1 
ATOM   3843 H HE21 . GLN A 1 256 ? -10.96553 -20.42165 42.76685  1.000 46.54560 ? 256 GLN A HE21 1 
ATOM   3844 H HE22 . GLN A 1 256 ? -11.13043 -21.26703 41.55127  1.000 46.54560 ? 256 GLN A HE22 1 
ATOM   3845 N N    . THR A 1 257 ? -15.11329 -16.12754 43.72504  1.000 28.51417 ? 257 THR A N    1 
ATOM   3846 C CA   . THR A 1 257 ? -14.36529 -14.88295 43.74607  1.000 24.85414 ? 257 THR A CA   1 
ATOM   3847 C C    . THR A 1 257 ? -14.95845 -13.81999 44.65552  1.000 30.91792 ? 257 THR A C    1 
ATOM   3848 O O    . THR A 1 257 ? -14.31735 -12.78661 44.86938  1.000 29.40822 ? 257 THR A O    1 
ATOM   3849 C CB   . THR A 1 257 ? -14.27028 -14.27201 42.33948  1.000 36.71718 ? 257 THR A CB   1 
ATOM   3850 O OG1  . THR A 1 257 ? -15.58333 -13.98374 41.83319  1.000 26.83525 ? 257 THR A OG1  1 
ATOM   3851 C CG2  . THR A 1 257 ? -13.56117 -15.23486 41.38414  1.000 30.38407 ? 257 THR A CG2  1 
ATOM   3852 H H    . THR A 1 257 ? -15.78109 -16.13874 43.18479  1.000 34.21701 ? 257 THR A H    1 
ATOM   3853 H HA   . THR A 1 257 ? -13.47322 -15.10044 44.05725  1.000 29.82497 ? 257 THR A HA   1 
ATOM   3854 H HB   . THR A 1 257 ? -13.75995 -13.44763 42.38517  1.000 44.06062 ? 257 THR A HB   1 
ATOM   3855 H HG1  . THR A 1 257 ? -16.03575 -14.69008 41.79160  1.000 32.20230 ? 257 THR A HG1  1 
ATOM   3856 H HG21 . THR A 1 257 ? -13.46319 -14.82424 40.51042  1.000 36.46088 ? 257 THR A HG21 1 
ATOM   3857 H HG22 . THR A 1 257 ? -12.68212 -15.45637 41.72831  1.000 36.46088 ? 257 THR A HG22 1 
ATOM   3858 H HG23 . THR A 1 257 ? -14.07749 -16.05121 41.29245  1.000 36.46088 ? 257 THR A HG23 1 
ATOM   3859 N N    . GLY A 1 258 ? -16.17147 -14.01726 45.14997  1.000 29.72126 ? 258 GLY A N    1 
ATOM   3860 C CA   . GLY A 1 258 ? -16.82858 -12.94122 45.86240  1.000 28.30300 ? 258 GLY A CA   1 
ATOM   3861 C C    . GLY A 1 258 ? -17.09926 -11.71692 45.03706  1.000 30.45692 ? 258 GLY A C    1 
ATOM   3862 O O    . GLY A 1 258 ? -17.22533 -10.62536 45.58369  1.000 25.11083 ? 258 GLY A O    1 
ATOM   3863 H H    . GLY A 1 258 ? -16.62287 -14.74658 45.08536  1.000 35.66551 ? 258 GLY A H    1 
ATOM   3864 H HA2  . GLY A 1 258 ? -17.67844 -13.26510 46.20090  1.000 33.96361 ? 258 GLY A HA2  1 
ATOM   3865 H HA3  . GLY A 1 258 ? -16.27105 -12.67724 46.61076  1.000 33.96361 ? 258 GLY A HA3  1 
ATOM   3866 N N    . ILE A 1 259 ? -17.19269 -11.84418 43.70894  1.000 27.81945 ? 259 ILE A N    1 
ATOM   3867 C CA   . ILE A 1 259 ? -17.52431 -10.69992 42.86553  1.000 26.70158 ? 259 ILE A CA   1 
ATOM   3868 C C    . ILE A 1 259 ? -18.88288 -10.95161 42.23090  1.000 31.15048 ? 259 ILE A C    1 
ATOM   3869 O O    . ILE A 1 259 ? -19.03486 -11.87724 41.41927  1.000 28.04333 ? 259 ILE A O    1 
ATOM   3870 C CB   . ILE A 1 259 ? -16.48513 -10.43442 41.77206  1.000 34.81956 ? 259 ILE A CB   1 
ATOM   3871 C CG1  . ILE A 1 259 ? -15.12861 -10.09470 42.35875  1.000 29.42441 ? 259 ILE A CG1  1 
ATOM   3872 C CG2  . ILE A 1 259 ? -16.98469 -9.32025  40.84357  1.000 32.72098 ? 259 ILE A CG2  1 
ATOM   3873 C CD1  . ILE A 1 259 ? -14.01404 -10.38122 41.39697  1.000 33.72914 ? 259 ILE A CD1  1 
ATOM   3874 H H    . ILE A 1 259 ? -17.06796 -12.57982 43.28054  1.000 33.38335 ? 259 ILE A H    1 
ATOM   3875 H HA   . ILE A 1 259 ? -17.58013 -9.92032  43.44099  1.000 32.04190 ? 259 ILE A HA   1 
ATOM   3876 H HB   . ILE A 1 259 ? -16.37130 -11.24802 41.25760  1.000 41.78348 ? 259 ILE A HB   1 
ATOM   3877 H HG12 . ILE A 1 259 ? -15.10444 -9.14982  42.57934  1.000 35.30929 ? 259 ILE A HG12 1 
ATOM   3878 H HG13 . ILE A 1 259 ? -14.98447 -10.62508 43.15748  1.000 35.30929 ? 259 ILE A HG13 1 
ATOM   3879 H HG21 . ILE A 1 259 ? -16.24375 -9.00333  40.30403  1.000 39.26517 ? 259 ILE A HG21 1 
ATOM   3880 H HG22 . ILE A 1 259 ? -17.68320 -9.67545  40.27211  1.000 39.26517 ? 259 ILE A HG22 1 
ATOM   3881 H HG23 . ILE A 1 259 ? -17.33646 -8.59486  41.38290  1.000 39.26517 ? 259 ILE A HG23 1 
ATOM   3882 H HD11 . ILE A 1 259 ? -13.16633 -10.20982 41.83537  1.000 40.47497 ? 259 ILE A HD11 1 
ATOM   3883 H HD12 . ILE A 1 259 ? -14.06320 -11.31110 41.12438  1.000 40.47497 ? 259 ILE A HD12 1 
ATOM   3884 H HD13 . ILE A 1 259 ? -14.10822 -9.80482  40.62229  1.000 40.47497 ? 259 ILE A HD13 1 
ATOM   3885 N N    . ALA A 1 260 ? -19.86667 -10.12062 42.59306  1.000 26.97940 ? 260 ALA A N    1 
ATOM   3886 C CA   . ALA A 1 260 ? -21.19539 -10.21632 42.01554  1.000 27.67778 ? 260 ALA A CA   1 
ATOM   3887 C C    . ALA A 1 260 ? -21.16898 -10.06436 40.49464  1.000 27.72500 ? 260 ALA A C    1 
ATOM   3888 O O    . ALA A 1 260 ? -20.42843 -9.24643  39.92840  1.000 27.98492 ? 260 ALA A O    1 
ATOM   3889 C CB   . ALA A 1 260 ? -22.09147 -9.15043  42.65688  1.000 31.31438 ? 260 ALA A CB   1 
ATOM   3890 H H    . ALA A 1 260 ? -19.78338 -9.49191  43.17348  1.000 32.37528 ? 260 ALA A H    1 
ATOM   3891 H HA   . ALA A 1 260 ? -21.56676 -11.09473 42.19486  1.000 33.21334 ? 260 ALA A HA   1 
ATOM   3892 H HB1  . ALA A 1 260 ? -22.94731 -9.14183  42.20158  1.000 37.57726 ? 260 ALA A HB1  1 
ATOM   3893 H HB2  . ALA A 1 260 ? -22.21663 -9.36511  43.59370  1.000 37.57726 ? 260 ALA A HB2  1 
ATOM   3894 H HB3  . ALA A 1 260 ? -21.66213 -8.28504  42.57056  1.000 37.57726 ? 260 ALA A HB3  1 
ATOM   3895 N N    . VAL A 1 261 ? -22.00611 -10.86063 39.84085  1.000 25.04780 ? 261 VAL A N    1 
ATOM   3896 C CA   . VAL A 1 261 ? -22.04761 -10.84676 38.38185  1.000 22.50709 ? 261 VAL A CA   1 
ATOM   3897 C C    . VAL A 1 261 ? -22.25056 -9.42661  37.87165  1.000 27.34067 ? 261 VAL A C    1 
ATOM   3898 O O    . VAL A 1 261 ? -21.56558 -8.98349  36.94816  1.000 23.11467 ? 261 VAL A O    1 
ATOM   3899 C CB   . VAL A 1 261 ? -23.11966 -11.81030 37.86487  1.000 29.01528 ? 261 VAL A CB   1 
ATOM   3900 C CG1  . VAL A 1 261 ? -23.26327 -11.63248 36.35893  1.000 26.89709 ? 261 VAL A CG1  1 
ATOM   3901 C CG2  . VAL A 1 261 ? -22.74864 -13.25323 38.22511  1.000 33.28608 ? 261 VAL A CG2  1 
ATOM   3902 H H    . VAL A 1 261 ? -22.55380 -11.41129 40.21132  1.000 30.05736 ? 261 VAL A H    1 
ATOM   3903 H HA   . VAL A 1 261 ? -21.19324 -11.15887 38.04495  1.000 27.00850 ? 261 VAL A HA   1 
ATOM   3904 H HB   . VAL A 1 261 ? -23.97496 -11.61823 38.28069  1.000 34.81834 ? 261 VAL A HB   1 
ATOM   3905 H HG11 . VAL A 1 261 ? -23.70151 -12.41461 35.98929  1.000 32.27651 ? 261 VAL A HG11 1 
ATOM   3906 H HG12 . VAL A 1 261 ? -23.79583 -10.84080 36.18423  1.000 32.27651 ? 261 VAL A HG12 1 
ATOM   3907 H HG13 . VAL A 1 261 ? -22.38121 -11.53054 35.96731  1.000 32.27651 ? 261 VAL A HG13 1 
ATOM   3908 H HG21 . VAL A 1 261 ? -23.37801 -13.85646 37.80052  1.000 39.94329 ? 261 VAL A HG21 1 
ATOM   3909 H HG22 . VAL A 1 261 ? -21.85038 -13.43632 37.91032  1.000 39.94329 ? 261 VAL A HG22 1 
ATOM   3910 H HG23 . VAL A 1 261 ? -22.78889 -13.35885 39.18903  1.000 39.94329 ? 261 VAL A HG23 1 
ATOM   3911 N N    . LEU A 1 262 ? -23.14339 -8.65571  38.50681  1.000 24.92702 ? 262 LEU A N    1 
ATOM   3912 C CA   . LEU A 1 262 ? -23.44926 -7.33362  37.96752  1.000 24.15630 ? 262 LEU A CA   1 
ATOM   3913 C C    . LEU A 1 262 ? -22.30712 -6.34584  38.17653  1.000 25.51609 ? 262 LEU A C    1 
ATOM   3914 O O    . LEU A 1 262 ? -22.17561 -5.38526  37.40917  1.000 27.33424 ? 262 LEU A O    1 
ATOM   3915 C CB   . LEU A 1 262 ? -24.74087 -6.84004  38.60237  1.000 32.78529 ? 262 LEU A CB   1 
ATOM   3916 C CG   . LEU A 1 262 ? -25.94410 -7.53161  37.96651  1.000 22.88852 ? 262 LEU A CG   1 
ATOM   3917 C CD1  . LEU A 1 262 ? -27.19777 -7.01005  38.68339  1.000 30.18736 ? 262 LEU A CD1  1 
ATOM   3918 C CD2  . LEU A 1 262 ? -26.04673 -7.32076  36.45961  1.000 36.54616 ? 262 LEU A CD2  1 
ATOM   3919 H H    . LEU A 1 262 ? -23.56648 -8.86949  39.22353  1.000 29.91242 ? 262 LEU A H    1 
ATOM   3920 H HA   . LEU A 1 262 ? -23.58087 -7.39213  37.00843  1.000 28.98756 ? 262 LEU A HA   1 
ATOM   3921 H HB2  . LEU A 1 262 ? -24.73305 -7.03962  39.55125  1.000 39.34234 ? 262 LEU A HB2  1 
ATOM   3922 H HB3  . LEU A 1 262 ? -24.82459 -5.88302  38.46493  1.000 39.34234 ? 262 LEU A HB3  1 
ATOM   3923 H HG   . LEU A 1 262 ? -25.85437 -8.49160  38.07095  1.000 27.46622 ? 262 LEU A HG   1 
ATOM   3924 H HD11 . LEU A 1 262 ? -27.97929 -7.44444  38.30785  1.000 36.22483 ? 262 LEU A HD11 1 
ATOM   3925 H HD12 . LEU A 1 262 ? -27.12794 -7.21357  39.62929  1.000 36.22483 ? 262 LEU A HD12 1 
ATOM   3926 H HD13 . LEU A 1 262 ? -27.25849 -6.05102  38.55496  1.000 36.22483 ? 262 LEU A HD13 1 
ATOM   3927 H HD21 . LEU A 1 262 ? -26.95749 -7.49831  36.17718  1.000 43.85539 ? 262 LEU A HD21 1 
ATOM   3928 H HD22 . LEU A 1 262 ? -25.80839 -6.40444  36.25126  1.000 43.85539 ? 262 LEU A HD22 1 
ATOM   3929 H HD23 . LEU A 1 262 ? -25.43809 -7.93000  36.01345  1.000 43.85539 ? 262 LEU A HD23 1 
ATOM   3930 N N    . ASP A 1 263 ? -21.48330 -6.56681  39.19168  1.000 25.10795 ? 263 ASP A N    1 
ATOM   3931 C CA   . ASP A 1 263 ? -20.26798 -5.78095  39.36160  1.000 20.53073 ? 263 ASP A CA   1 
ATOM   3932 C C    . ASP A 1 263 ? -19.25134 -6.09646  38.26076  1.000 27.68927 ? 263 ASP A C    1 
ATOM   3933 O O    . ASP A 1 263 ? -18.60988 -5.18462  37.72455  1.000 30.07864 ? 263 ASP A O    1 
ATOM   3934 C CB   . ASP A 1 263 ? -19.68223 -6.08533  40.74262  1.000 29.56181 ? 263 ASP A CB   1 
ATOM   3935 C CG   . ASP A 1 263 ? -20.54707 -5.53673  41.89565  1.000 28.04554 ? 263 ASP A CG   1 
ATOM   3936 O OD1  . ASP A 1 263 ? -21.59251 -4.88742  41.66568  1.000 26.98858 ? 263 ASP A OD1  1 
ATOM   3937 O OD2  . ASP A 1 263 ? -20.20322 -5.86517  43.05557  1.000 33.01710 ? 263 ASP A OD2  1 
ATOM   3938 H H    . ASP A 1 263 ? -21.60304 -7.16528  39.79727  1.000 30.12954 ? 263 ASP A H    1 
ATOM   3939 H HA   . ASP A 1 263 ? -20.47472 -4.83508  39.30811  1.000 24.63688 ? 263 ASP A HA   1 
ATOM   3940 H HB2  . ASP A 1 263 ? -19.61250 -7.04634  40.85205  1.000 35.47417 ? 263 ASP A HB2  1 
ATOM   3941 H HB3  . ASP A 1 263 ? -18.80358 -5.67967  40.80918  1.000 35.47417 ? 263 ASP A HB3  1 
ATOM   3942 N N    . MET A 1 264 ? -19.09420 -7.37612  37.91403  1.000 29.06090 ? 264 MET A N    1 
ATOM   3943 C CA   . MET A 1 264 ? -18.22052 -7.73274  36.79712  1.000 26.98238 ? 264 MET A CA   1 
ATOM   3944 C C    . MET A 1 264 ? -18.74552 -7.15835  35.48428  1.000 23.24067 ? 264 MET A C    1 
ATOM   3945 O O    . MET A 1 264 ? -17.96662 -6.66522  34.66686  1.000 31.52213 ? 264 MET A O    1 
ATOM   3946 C CB   . MET A 1 264 ? -18.05628 -9.25155  36.71024  1.000 27.50003 ? 264 MET A CB   1 
ATOM   3947 C CG   . MET A 1 264 ? -16.85927 -9.69607  35.86488  1.000 25.60607 ? 264 MET A CG   1 
ATOM   3948 S SD   . MET A 1 264 ? -15.23440 -9.12607  36.43975  1.000 26.90024 ? 264 MET A SD   1 
ATOM   3949 C CE   . MET A 1 264 ? -14.75910 -10.57244 37.37645  1.000 29.22015 ? 264 MET A CE   1 
ATOM   3950 H H    . MET A 1 264 ? -19.47481 -8.04366  38.30048  1.000 34.87308 ? 264 MET A H    1 
ATOM   3951 H HA   . MET A 1 264 ? -17.33988 -7.36314  36.96265  1.000 32.37886 ? 264 MET A HA   1 
ATOM   3952 H HB2  . MET A 1 264 ? -17.93272 -9.60305  37.60610  1.000 33.00004 ? 264 MET A HB2  1 
ATOM   3953 H HB3  . MET A 1 264 ? -18.85668 -9.62991  36.31336  1.000 33.00004 ? 264 MET A HB3  1 
ATOM   3954 H HG2  . MET A 1 264 ? -16.83645 -10.66599 35.85402  1.000 30.72728 ? 264 MET A HG2  1 
ATOM   3955 H HG3  . MET A 1 264 ? -16.98035 -9.35756  34.96431  1.000 30.72728 ? 264 MET A HG3  1 
ATOM   3956 H HE1  . MET A 1 264 ? -13.88138 -10.42476 37.76258  1.000 35.06418 ? 264 MET A HE1  1 
ATOM   3957 H HE2  . MET A 1 264 ? -15.40892 -10.72047 38.08089  1.000 35.06418 ? 264 MET A HE2  1 
ATOM   3958 H HE3  . MET A 1 264 ? -14.73360 -11.33978 36.78272  1.000 35.06418 ? 264 MET A HE3  1 
ATOM   3959 N N    . CYS A 1 265 ? -20.06045 -7.15127  35.29082  1.000 24.79987 ? 265 CYS A N    1 
ATOM   3960 C CA   . CYS A 1 265 ? -20.62360 -6.45601  34.13505  1.000 23.98888 ? 265 CYS A CA   1 
ATOM   3961 C C    . CYS A 1 265 ? -20.22877 -4.98068  34.11110  1.000 24.25621 ? 265 CYS A C    1 
ATOM   3962 O O    . CYS A 1 265 ? -20.00585 -4.39684  33.04254  1.000 27.49051 ? 265 CYS A O    1 
ATOM   3963 C CB   . CYS A 1 265 ? -22.14250 -6.57320  34.10945  1.000 30.06150 ? 265 CYS A CB   1 
ATOM   3964 S SG   . CYS A 1 265 ? -22.82414 -8.20664  33.93420  1.000 26.81729 ? 265 CYS A SG   1 
ATOM   3965 H H    . CYS A 1 265 ? -20.63833 -7.53205  35.80139  1.000 29.75984 ? 265 CYS A H    1 
ATOM   3966 H HA   . CYS A 1 265 ? -20.27098 -6.88724  33.34091  1.000 28.78666 ? 265 CYS A HA   1 
ATOM   3967 H HB2  . CYS A 1 265 ? -22.48508 -6.21299  34.94255  1.000 36.07380 ? 265 CYS A HB2  1 
ATOM   3968 H HB3  . CYS A 1 265 ? -22.47065 -6.05000  33.36165  1.000 36.07380 ? 265 CYS A HB3  1 
ATOM   3969 H HG   . CYS A 1 265 ? -22.50895 -8.86497  34.88690  1.000 32.18075 ? 265 CYS A HG   1 
ATOM   3970 N N    . ALA A 1 266 ? -20.14069 -4.34533  35.28853  1.000 22.82595 ? 266 ALA A N    1 
ATOM   3971 C CA   . ALA A 1 266 ? -19.79182 -2.93207  35.31852  1.000 25.31896 ? 266 ALA A CA   1 
ATOM   3972 C C    . ALA A 1 266 ? -18.33485 -2.72668  34.93916  1.000 26.73857 ? 266 ALA A C    1 
ATOM   3973 O O    . ALA A 1 266 ? -17.99237 -1.76298  34.24388  1.000 27.09705 ? 266 ALA A O    1 
ATOM   3974 C CB   . ALA A 1 266 ? -20.07477 -2.35015  36.70278  1.000 33.33794 ? 266 ALA A CB   1 
ATOM   3975 H H    . ALA A 1 266 ? -20.27467 -4.70392  36.05826  1.000 27.39114 ? 266 ALA A H    1 
ATOM   3976 H HA   . ALA A 1 266 ? -20.34297 -2.45612  34.67762  1.000 30.38275 ? 266 ALA A HA   1 
ATOM   3977 H HB1  . ALA A 1 266 ? -19.89253 -1.39800  36.68843  1.000 40.00553 ? 266 ALA A HB1  1 
ATOM   3978 H HB2  . ALA A 1 266 ? -21.00573 -2.50503  36.92636  1.000 40.00553 ? 266 ALA A HB2  1 
ATOM   3979 H HB3  . ALA A 1 266 ? -19.50166 -2.78710  37.35271  1.000 40.00553 ? 266 ALA A HB3  1 
ATOM   3980 N N    . SER A 1 267 ? -17.46029 -3.62826  35.38091  1.000 23.16196 ? 267 SER A N    1 
ATOM   3981 C CA   . SER A 1 267 ? -16.07915 -3.59287  34.90942  1.000 36.29296 ? 267 SER A CA   1 
ATOM   3982 C C    . SER A 1 267 ? -16.02649 -3.74889  33.39935  1.000 23.81440 ? 267 SER A C    1 
ATOM   3983 O O    . SER A 1 267 ? -15.27281 -3.04687  32.71604  1.000 32.59775 ? 267 SER A O    1 
ATOM   3984 C CB   . SER A 1 267 ? -15.26550 -4.70663  35.56902  1.000 35.72942 ? 267 SER A CB   1 
ATOM   3985 O OG   . SER A 1 267 ? -15.13918 -4.46638  36.95622  1.000 40.90587 ? 267 SER A OG   1 
ATOM   3986 H H    . SER A 1 267 ? -17.63699 -4.25674  35.94146  1.000 27.79435 ? 267 SER A H    1 
ATOM   3987 H HA   . SER A 1 267 ? -15.68892 -2.74071  35.15709  1.000 43.55156 ? 267 SER A HA   1 
ATOM   3988 H HB2  . SER A 1 267 ? -15.71777 -5.55390  35.43334  1.000 42.87530 ? 267 SER A HB2  1 
ATOM   3989 H HB3  . SER A 1 267 ? -14.38233 -4.73468  35.16932  1.000 42.87530 ? 267 SER A HB3  1 
ATOM   3990 H HG   . SER A 1 267 ? -14.91776 -5.17345  37.35186  1.000 49.08705 ? 267 SER A HG   1 
ATOM   3991 N N    . LEU A 1 268 ? -16.78955 -4.70318  32.87249  1.000 23.19843 ? 268 LEU A N    1 
ATOM   3992 C CA   . LEU A 1 268 ? -16.77783 -4.96628  31.43133  1.000 21.61848 ? 268 LEU A CA   1 
ATOM   3993 C C    . LEU A 1 268 ? -17.26352 -3.75418  30.64890  1.000 25.46531 ? 268 LEU A C    1 
ATOM   3994 O O    . LEU A 1 268 ? -16.66247 -3.36809  29.64435  1.000 28.78019 ? 268 LEU A O    1 
ATOM   3995 C CB   . LEU A 1 268 ? -17.62474 -6.19476  31.11627  1.000 23.56473 ? 268 LEU A CB   1 
ATOM   3996 C CG   . LEU A 1 268 ? -17.83395 -6.52702  29.63799  1.000 18.85585 ? 268 LEU A CG   1 
ATOM   3997 C CD1  . LEU A 1 268 ? -16.51550 -6.76051  28.89331  1.000 20.37707 ? 268 LEU A CD1  1 
ATOM   3998 C CD2  . LEU A 1 268 ? -18.70592 -7.75461  29.47993  1.000 23.70994 ? 268 LEU A CD2  1 
ATOM   3999 H H    . LEU A 1 268 ? -17.32030 -5.20988  33.32099  1.000 27.83812 ? 268 LEU A H    1 
ATOM   4000 H HA   . LEU A 1 268 ? -15.86658 -5.15438  31.15453  1.000 25.94218 ? 268 LEU A HA   1 
ATOM   4001 H HB2  . LEU A 1 268 ? -17.19827 -6.96467  31.52295  1.000 28.27768 ? 268 LEU A HB2  1 
ATOM   4002 H HB3  . LEU A 1 268 ? -18.50398 -6.05870  31.50305  1.000 28.27768 ? 268 LEU A HB3  1 
ATOM   4003 H HG   . LEU A 1 268 ? -18.27042 -5.75912  29.23931  1.000 22.62702 ? 268 LEU A HG   1 
ATOM   4004 H HD11 . LEU A 1 268 ? -16.71000 -6.98609  27.97011  1.000 24.45248 ? 268 LEU A HD11 1 
ATOM   4005 H HD12 . LEU A 1 268 ? -15.98416 -5.95011  28.93100  1.000 24.45248 ? 268 LEU A HD12 1 
ATOM   4006 H HD13 . LEU A 1 268 ? -16.03807 -7.49039  29.31803  1.000 24.45248 ? 268 LEU A HD13 1 
ATOM   4007 H HD21 . LEU A 1 268 ? -18.80443 -7.95211  28.53577  1.000 28.45193 ? 268 LEU A HD21 1 
ATOM   4008 H HD22 . LEU A 1 268 ? -18.28349 -8.50156  29.93262  1.000 28.45193 ? 268 LEU A HD22 1 
ATOM   4009 H HD23 . LEU A 1 268 ? -19.57420 -7.57655  29.87373  1.000 28.45193 ? 268 LEU A HD23 1 
ATOM   4010 N N    . LYS A 1 269 ? -18.37514 -3.16733  31.07787  1.000 26.84212 ? 269 LYS A N    1 
ATOM   4011 C CA   . LYS A 1 269 ? -18.86793 -1.91637  30.50147  1.000 27.41337 ? 269 LYS A CA   1 
ATOM   4012 C C    . LYS A 1 269 ? -17.75270 -0.88040  30.36250  1.000 27.39497 ? 269 LYS A C    1 
ATOM   4013 O O    . LYS A 1 269 ? -17.58081 -0.27460  29.29894  1.000 29.02134 ? 269 LYS A O    1 
ATOM   4014 C CB   . LYS A 1 269 ? -19.99366 -1.39682  31.40040  1.000 27.96912 ? 269 LYS A CB   1 
ATOM   4015 C CG   . LYS A 1 269 ? -20.63861 -0.06114  31.09099  1.000 36.88974 ? 269 LYS A CG   1 
ATOM   4016 C CD   . LYS A 1 269 ? -22.09677 -0.08660  31.57446  1.000 35.57853 ? 269 LYS A CD   1 
ATOM   4017 C CE   . LYS A 1 269 ? -22.47202 1.07853   32.49505  1.000 50.76857 ? 269 LYS A CE   1 
ATOM   4018 N NZ   . LYS A 1 269 ? -21.94694 2.43022   32.06007  1.000 50.13402 ? 269 LYS A NZ   1 
ATOM   4019 H H    . LYS A 1 269 ? -18.87112 -3.47412  31.71051  1.000 32.21054 ? 269 LYS A H    1 
ATOM   4020 H HA   . LYS A 1 269 ? -19.21349 -2.07509  29.60925  1.000 32.89605 ? 269 LYS A HA   1 
ATOM   4021 H HB2  . LYS A 1 269 ? -20.70713 -2.05338  31.37974  1.000 33.56295 ? 269 LYS A HB2  1 
ATOM   4022 H HB3  . LYS A 1 269 ? -19.63604 -1.32409  32.29957  1.000 33.56295 ? 269 LYS A HB3  1 
ATOM   4023 H HG2  . LYS A 1 269 ? -20.16534 0.64895   31.55260  1.000 44.26768 ? 269 LYS A HG2  1 
ATOM   4024 H HG3  . LYS A 1 269 ? -20.62540 0.09846   30.13509  1.000 44.26768 ? 269 LYS A HG3  1 
ATOM   4025 H HD2  . LYS A 1 269 ? -22.68052 -0.05059  30.80128  1.000 42.69424 ? 269 LYS A HD2  1 
ATOM   4026 H HD3  . LYS A 1 269 ? -22.24728 -0.91002  32.06590  1.000 42.69424 ? 269 LYS A HD3  1 
ATOM   4027 H HE2  . LYS A 1 269 ? -23.43908 1.14174   32.53374  1.000 60.92229 ? 269 LYS A HE2  1 
ATOM   4028 H HE3  . LYS A 1 269 ? -22.11519 0.89927   33.37906  1.000 60.92229 ? 269 LYS A HE3  1 
ATOM   4029 H HZ1  . LYS A 1 269 ? -21.89262 2.97483   32.76142  1.000 60.16083 ? 269 LYS A HZ1  1 
ATOM   4030 H HZ2  . LYS A 1 269 ? -21.13874 2.34109   31.69930  1.000 60.16083 ? 269 LYS A HZ2  1 
ATOM   4031 H HZ3  . LYS A 1 269 ? -22.49501 2.78916   31.45709  1.000 60.16083 ? 269 LYS A HZ3  1 
ATOM   4032 N N    . GLU A 1 270 ? -16.98225 -0.66444  31.42991  1.000 22.38919 ? 270 GLU A N    1 
ATOM   4033 C CA   . GLU A 1 270 ? -15.95105 0.35640   31.40290  1.000 24.98695 ? 270 GLU A CA   1 
ATOM   4034 C C    . GLU A 1 270 ? -14.87342 0.01189   30.38107  1.000 33.01287 ? 270 GLU A C    1 
ATOM   4035 O O    . GLU A 1 270 ? -14.30888 0.89174   29.71781  1.000 34.17827 ? 270 GLU A O    1 
ATOM   4036 C CB   . GLU A 1 270 ? -15.31665 0.48505   32.78921  1.000 30.03695 ? 270 GLU A CB   1 
ATOM   4037 C CG   . GLU A 1 270 ? -16.17855 1.17574   33.79433  1.000 40.29017 ? 270 GLU A CG   1 
ATOM   4038 C CD   . GLU A 1 270 ? -16.63946 2.52767   33.31200  1.000 46.27936 ? 270 GLU A CD   1 
ATOM   4039 O OE1  . GLU A 1 270 ? -15.78104 3.38954   33.01783  1.000 52.15959 ? 270 GLU A OE1  1 
ATOM   4040 O OE2  . GLU A 1 270 ? -17.87555 2.70378   33.16967  1.000 45.48422 ? 270 GLU A OE2  1 
ATOM   4041 H H    . GLU A 1 270 ? -17.04017 -1.09394  32.17262  1.000 26.86703 ? 270 GLU A H    1 
ATOM   4042 H HA   . GLU A 1 270 ? -16.35465 1.20523   31.16228  1.000 29.98433 ? 270 GLU A HA   1 
ATOM   4043 H HB2  . GLU A 1 270 ? -15.12606 -0.40401  33.12673  1.000 36.04433 ? 270 GLU A HB2  1 
ATOM   4044 H HB3  . GLU A 1 270 ? -14.49402 0.99275   32.70781  1.000 36.04433 ? 270 GLU A HB3  1 
ATOM   4045 H HG2  . GLU A 1 270 ? -16.96318 0.63301   33.96772  1.000 48.34820 ? 270 GLU A HG2  1 
ATOM   4046 H HG3  . GLU A 1 270 ? -15.67494 1.30264   34.61258  1.000 48.34820 ? 270 GLU A HG3  1 
ATOM   4047 N N    . LEU A 1 271 ? -14.55735 -1.27479  30.26639  1.000 29.80007 ? 271 LEU A N    1 
ATOM   4048 C CA   . LEU A 1 271 ? -13.61164 -1.72742  29.25844  1.000 27.53961 ? 271 LEU A CA   1 
ATOM   4049 C C    . LEU A 1 271 ? -14.16029 -1.53999  27.85236  1.000 29.65959 ? 271 LEU A C    1 
ATOM   4050 O O    . LEU A 1 271 ? -13.40823 -1.19882  26.92684  1.000 31.78569 ? 271 LEU A O    1 
ATOM   4051 C CB   . LEU A 1 271 ? -13.28156 -3.19631  29.51365  1.000 29.64595 ? 271 LEU A CB   1 
ATOM   4052 C CG   . LEU A 1 271 ? -12.39665 -3.60434  30.69871  1.000 34.69922 ? 271 LEU A CG   1 
ATOM   4053 C CD1  . LEU A 1 271 ? -12.54051 -5.11456  30.86273  1.000 29.97080 ? 271 LEU A CD1  1 
ATOM   4054 C CD2  . LEU A 1 271 ? -10.94788 -3.22705  30.48346  1.000 32.05472 ? 271 LEU A CD2  1 
ATOM   4055 H H    . LEU A 1 271 ? -14.87703 -1.90335  30.75889  1.000 35.76009 ? 271 LEU A H    1 
ATOM   4056 H HA   . LEU A 1 271 ? -12.79708 -1.20481  29.32505  1.000 33.04753 ? 271 LEU A HA   1 
ATOM   4057 H HB2  . LEU A 1 271 ? -14.12523 -3.65906  29.63807  1.000 35.57514 ? 271 LEU A HB2  1 
ATOM   4058 H HB3  . LEU A 1 271 ? -12.83501 -3.52847  28.71961  1.000 35.57514 ? 271 LEU A HB3  1 
ATOM   4059 H HG   . LEU A 1 271 ? -12.67431 -3.13806  31.50290  1.000 41.63907 ? 271 LEU A HG   1 
ATOM   4060 H HD11 . LEU A 1 271 ? -12.01755 -5.40061  31.62774  1.000 35.96496 ? 271 LEU A HD11 1 
ATOM   4061 H HD12 . LEU A 1 271 ? -13.47639 -5.32939  31.00227  1.000 35.96496 ? 271 LEU A HD12 1 
ATOM   4062 H HD13 . LEU A 1 271 ? -12.21788 -5.55080  30.05858  1.000 35.96496 ? 271 LEU A HD13 1 
ATOM   4063 H HD21 . LEU A 1 271 ? -10.43494 -3.48713  31.26448  1.000 38.46566 ? 271 LEU A HD21 1 
ATOM   4064 H HD22 . LEU A 1 271 ? -10.61423 -3.69131  29.70029  1.000 38.46566 ? 271 LEU A HD22 1 
ATOM   4065 H HD23 . LEU A 1 271 ? -10.88759 -2.26892  30.35107  1.000 38.46566 ? 271 LEU A HD23 1 
ATOM   4066 N N    . LEU A 1 272 ? -15.45503 -1.78690  27.65876  1.000 24.75451 ? 272 LEU A N    1 
ATOM   4067 C CA   . LEU A 1 272 ? -16.04572 -1.59056  26.34067  1.000 30.49565 ? 272 LEU A CA   1 
ATOM   4068 C C    . LEU A 1 272 ? -16.00975 -0.11529  25.95459  1.000 34.66843 ? 272 LEU A C    1 
ATOM   4069 O O    . LEU A 1 272 ? -15.62964 0.23570   24.83494  1.000 34.30921 ? 272 LEU A O    1 
ATOM   4070 C CB   . LEU A 1 272 ? -17.46629 -2.12469  26.33684  1.000 21.46577 ? 272 LEU A CB   1 
ATOM   4071 C CG   . LEU A 1 272 ? -17.53008 -3.65676  26.36587  1.000 21.64219 ? 272 LEU A CG   1 
ATOM   4072 C CD1  . LEU A 1 272 ? -18.97276 -4.08794  26.41909  1.000 23.63700 ? 272 LEU A CD1  1 
ATOM   4073 C CD2  . LEU A 1 272 ? -16.78519 -4.25544  25.19576  1.000 27.95454 ? 272 LEU A CD2  1 
ATOM   4074 H H    . LEU A 1 272 ? -16.00202 -2.06271  28.26239  1.000 29.70542 ? 272 LEU A H    1 
ATOM   4075 H HA   . LEU A 1 272 ? -15.54309 -2.08575  25.67454  1.000 36.59478 ? 272 LEU A HA   1 
ATOM   4076 H HB2  . LEU A 1 272 ? -17.92883 -1.79054  27.12088  1.000 25.75893 ? 272 LEU A HB2  1 
ATOM   4077 H HB3  . LEU A 1 272 ? -17.91425 -1.82155  25.53187  1.000 25.75893 ? 272 LEU A HB3  1 
ATOM   4078 H HG   . LEU A 1 272 ? -17.08809 -3.99889  27.15881  1.000 25.97063 ? 272 LEU A HG   1 
ATOM   4079 H HD11 . LEU A 1 272 ? -19.01003 -5.05004  26.53249  1.000 28.36440 ? 272 LEU A HD11 1 
ATOM   4080 H HD12 . LEU A 1 272 ? -19.40537 -3.64874  27.16721  1.000 28.36440 ? 272 LEU A HD12 1 
ATOM   4081 H HD13 . LEU A 1 272 ? -19.40867 -3.83577  25.59010  1.000 28.36440 ? 272 LEU A HD13 1 
ATOM   4082 H HD21 . LEU A 1 272 ? -17.01542 -5.19458  25.12210  1.000 33.54545 ? 272 LEU A HD21 1 
ATOM   4083 H HD22 . LEU A 1 272 ? -17.04128 -3.78715  24.38496  1.000 33.54545 ? 272 LEU A HD22 1 
ATOM   4084 H HD23 . LEU A 1 272 ? -15.83132 -4.15878  25.34516  1.000 33.54545 ? 272 LEU A HD23 1 
ATOM   4085 N N    . GLN A 1 273 ? -16.34579 0.76586   26.89701  1.000 35.31507 ? 273 GLN A N    1 
ATOM   4086 C CA   . GLN A 1 273 ? -16.41682 2.19398   26.60787  1.000 37.09438 ? 273 GLN A CA   1 
ATOM   4087 C C    . GLN A 1 273 ? -15.04935 2.86909   26.57977  1.000 33.43598 ? 273 GLN A C    1 
ATOM   4088 O O    . GLN A 1 273 ? -14.88792 3.88664   25.90245  1.000 35.64258 ? 273 GLN A O    1 
ATOM   4089 C CB   . GLN A 1 273 ? -17.31373 2.87064   27.63697  1.000 34.44893 ? 273 GLN A CB   1 
ATOM   4090 C CG   . GLN A 1 273 ? -18.75434 2.39049   27.62717  1.000 34.67454 ? 273 GLN A CG   1 
ATOM   4091 C CD   . GLN A 1 273 ? -19.58123 3.01216   28.73126  1.000 27.59695 ? 273 GLN A CD   1 
ATOM   4092 O OE1  . GLN A 1 273 ? -19.07012 3.77806   29.54391  1.000 39.02943 ? 273 GLN A OE1  1 
ATOM   4093 N NE2  . GLN A 1 273 ? -20.86999 2.70312   28.75261  1.000 37.53237 ? 273 GLN A NE2  1 
ATOM   4094 H H    . GLN A 1 273 ? -16.53691 0.56121   27.70982  1.000 42.37808 ? 273 GLN A H    1 
ATOM   4095 H HA   . GLN A 1 273 ? -16.80460 2.31022   25.72580  1.000 44.51325 ? 273 GLN A HA   1 
ATOM   4096 H HB2  . GLN A 1 273 ? -16.95290 2.69938   28.52099  1.000 41.33872 ? 273 GLN A HB2  1 
ATOM   4097 H HB3  . GLN A 1 273 ? -17.32042 3.82474   27.46056  1.000 41.33872 ? 273 GLN A HB3  1 
ATOM   4098 H HG2  . GLN A 1 273 ? -19.16123 2.62569   26.77817  1.000 41.60945 ? 273 GLN A HG2  1 
ATOM   4099 H HG3  . GLN A 1 273 ? -18.76862 1.42841   27.74657  1.000 41.60945 ? 273 GLN A HG3  1 
ATOM   4100 H HE21 . GLN A 1 273 ? -21.19536 2.17322   28.15817  1.000 45.03885 ? 273 GLN A HE21 1 
ATOM   4101 H HE22 . GLN A 1 273 ? -21.38146 3.03133   29.36164  1.000 45.03885 ? 273 GLN A HE22 1 
ATOM   4102 N N    . ASN A 1 274 ? -14.06718 2.33543   27.29679  1.000 33.53275 ? 274 ASN A N    1 
ATOM   4103 C CA   . ASN A 1 274 ? -12.77775 2.99337   27.43765  1.000 39.82073 ? 274 ASN A CA   1 
ATOM   4104 C C    . ASN A 1 274 ? -11.61793 2.23668   26.81359  1.000 40.64688 ? 274 ASN A C    1 
ATOM   4105 O O    . ASN A 1 274 ? -10.50334 2.77259   26.76831  1.000 33.69572 ? 274 ASN A O    1 
ATOM   4106 C CB   . ASN A 1 274 ? -12.49247 3.23068   28.92789  1.000 42.90204 ? 274 ASN A CB   1 
ATOM   4107 C CG   . ASN A 1 274 ? -13.51042 4.15549   29.54811  1.000 38.96235 ? 274 ASN A CG   1 
ATOM   4108 O OD1  . ASN A 1 274 ? -14.19550 3.81734   30.51866  1.000 47.64544 ? 274 ASN A OD1  1 
ATOM   4109 N ND2  . ASN A 1 274 ? -13.64315 5.33575   28.95779  1.000 41.30879 ? 274 ASN A ND2  1 
ATOM   4110 H H    . ASN A 1 274 ? -14.12573 1.58513   27.71330  1.000 40.23930 ? 274 ASN A H    1 
ATOM   4111 H HA   . ASN A 1 274 ? -12.81628 3.85362   26.98916  1.000 47.78487 ? 274 ASN A HA   1 
ATOM   4112 H HB2  . ASN A 1 274 ? -12.52396 2.38336   29.39836  1.000 51.48245 ? 274 ASN A HB2  1 
ATOM   4113 H HB3  . ASN A 1 274 ? -11.61482 3.63332   29.02645  1.000 51.48245 ? 274 ASN A HB3  1 
ATOM   4114 H HD21 . ASN A 1 274 ? -13.16606 5.52855   28.26907  1.000 49.57055 ? 274 ASN A HD21 1 
ATOM   4115 H HD22 . ASN A 1 274 ? -14.20772 5.90811   29.26394  1.000 49.57055 ? 274 ASN A HD22 1 
ATOM   4116 N N    . GLY A 1 275 ? -11.84979 1.02680   26.31376  1.000 43.59563 ? 275 GLY A N    1 
ATOM   4117 C CA   . GLY A 1 275 ? -10.74798 0.19995   25.87764  1.000 40.14305 ? 275 GLY A CA   1 
ATOM   4118 C C    . GLY A 1 275 ? -9.92203  -0.25813  27.07065  1.000 43.28481 ? 275 GLY A C    1 
ATOM   4119 O O    . GLY A 1 275 ? -10.33151 -0.16717  28.23056  1.000 40.75198 ? 275 GLY A O    1 
ATOM   4120 H H    . GLY A 1 275 ? -12.62747 0.67124   26.22027  1.000 52.31476 ? 275 GLY A H    1 
ATOM   4121 H HA2  . GLY A 1 275 ? -11.08719 -0.58104  25.41304  1.000 48.17166 ? 275 GLY A HA2  1 
ATOM   4122 H HA3  . GLY A 1 275 ? -10.17716 0.70277   25.27615  1.000 48.17166 ? 275 GLY A HA3  1 
ATOM   4123 N N    . MET A 1 276 ? -8.72552  -0.75999  26.75776  1.000 46.84647 ? 276 MET A N    1 
ATOM   4124 C CA   . MET A 1 276 ? -7.82243  -1.31488  27.75274  1.000 44.36666 ? 276 MET A CA   1 
ATOM   4125 C C    . MET A 1 276 ? -6.58119  -0.45202  27.96271  1.000 44.29636 ? 276 MET A C    1 
ATOM   4126 O O    . MET A 1 276 ? -5.64509  -0.88069  28.63878  1.000 44.49012 ? 276 MET A O    1 
ATOM   4127 C CB   . MET A 1 276 ? -7.43616  -2.74233  27.35700  1.000 42.02202 ? 276 MET A CB   1 
ATOM   4128 C CG   . MET A 1 276 ? -8.56990  -3.73325  27.62890  1.000 47.33585 ? 276 MET A CG   1 
ATOM   4129 S SD   . MET A 1 276 ? -8.52332  -5.30211  26.71965  1.000 54.67720 ? 276 MET A SD   1 
ATOM   4130 C CE   . MET A 1 276 ? -7.12534  -5.99416  27.63539  1.000 23.25315 ? 276 MET A CE   1 
ATOM   4131 H H    . MET A 1 276 ? -8.41322  -0.78824  25.95686  1.000 56.21576 ? 276 MET A H    1 
ATOM   4132 H HA   . MET A 1 276 ? -8.28669  -1.36577  28.60254  1.000 53.23999 ? 276 MET A HA   1 
ATOM   4133 H HB2  . MET A 1 276 ? -7.23177  -2.76695  26.40886  1.000 50.42643 ? 276 MET A HB2  1 
ATOM   4134 H HB3  . MET A 1 276 ? -6.66084  -3.01780  27.87100  1.000 50.42643 ? 276 MET A HB3  1 
ATOM   4135 H HG2  . MET A 1 276 ? -8.55458  -3.95409  28.57318  1.000 56.80302 ? 276 MET A HG2  1 
ATOM   4136 H HG3  . MET A 1 276 ? -9.40803  -3.30117  27.40201  1.000 56.80302 ? 276 MET A HG3  1 
ATOM   4137 H HE1  . MET A 1 276 ? -6.92630  -6.87748  27.28764  1.000 27.90378 ? 276 MET A HE1  1 
ATOM   4138 H HE2  . MET A 1 276 ? -6.35617  -5.41308  27.52347  1.000 27.90378 ? 276 MET A HE2  1 
ATOM   4139 H HE3  . MET A 1 276 ? -7.36095  -6.05304  28.57367  1.000 27.90378 ? 276 MET A HE3  1 
ATOM   4140 N N    . ASN A 1 277 ? -6.56998  0.77131   27.44147  1.000 42.93706 ? 277 ASN A N    1 
ATOM   4141 C CA   . ASN A 1 277 ? -5.51085  1.71996   27.76043  1.000 47.03552 ? 277 ASN A CA   1 
ATOM   4142 C C    . ASN A 1 277 ? -4.13129  1.10317   27.57353  1.000 51.80767 ? 277 ASN A C    1 
ATOM   4143 O O    . ASN A 1 277 ? -3.19779  1.38344   28.34204  1.000 58.10239 ? 277 ASN A O    1 
ATOM   4144 C CB   . ASN A 1 277 ? -5.65277  2.23796   29.19170  1.000 47.91287 ? 277 ASN A CB   1 
ATOM   4145 C CG   . ASN A 1 277 ? -6.33285  3.57639   29.24728  1.000 58.94478 ? 277 ASN A CG   1 
ATOM   4146 O OD1  . ASN A 1 277 ? -5.70260  4.61302   29.03014  1.000 60.32351 ? 277 ASN A OD1  1 
ATOM   4147 N ND2  . ASN A 1 277 ? -7.63595  3.57117   29.53782  1.000 63.93181 ? 277 ASN A ND2  1 
ATOM   4148 H H    . ASN A 1 277 ? -7.16603  1.07517   26.90044  1.000 51.52447 ? 277 ASN A H    1 
ATOM   4149 H HA   . ASN A 1 277 ? -5.58923  2.46827   27.14786  1.000 56.44263 ? 277 ASN A HA   1 
ATOM   4150 H HB2  . ASN A 1 277 ? -6.18145  1.60922   29.70712  1.000 57.49544 ? 277 ASN A HB2  1 
ATOM   4151 H HB3  . ASN A 1 277 ? -4.77098  2.33142   29.58507  1.000 57.49544 ? 277 ASN A HB3  1 
ATOM   4152 H HD21 . ASN A 1 277 ? -8.06956  4.31280   29.58112  1.000 76.71817 ? 277 ASN A HD21 1 
ATOM   4153 H HD22 . ASN A 1 277 ? -8.04141  2.82676   29.68122  1.000 76.71817 ? 277 ASN A HD22 1 
ATOM   4154 N N    . GLY A 1 278 ? -4.01124  0.23088   26.57704  1.000 39.58447 ? 278 GLY A N    1 
ATOM   4155 C CA   . GLY A 1 278 ? -2.77360  -0.45296  26.29205  1.000 45.51989 ? 278 GLY A CA   1 
ATOM   4156 C C    . GLY A 1 278 ? -2.38209  -1.52626  27.27653  1.000 39.76164 ? 278 GLY A C    1 
ATOM   4157 O O    . GLY A 1 278 ? -1.25267  -2.02331  27.20162  1.000 37.17132 ? 278 GLY A O    1 
ATOM   4158 H H    . GLY A 1 278 ? -4.65189  0.01870   26.04368  1.000 47.50136 ? 278 GLY A H    1 
ATOM   4159 H HA2  . GLY A 1 278 ? -2.84596  -0.86948  25.41877  1.000 54.62387 ? 278 GLY A HA2  1 
ATOM   4160 H HA3  . GLY A 1 278 ? -2.05811  0.20062   26.27171  1.000 54.62387 ? 278 GLY A HA3  1 
ATOM   4161 N N    . ARG A 1 279 ? -3.27612  -1.90153  28.18398  1.000 41.50956 ? 279 ARG A N    1 
ATOM   4162 C CA   . ARG A 1 279 ? -3.00467  -2.90794  29.19946  1.000 35.40451 ? 279 ARG A CA   1 
ATOM   4163 C C    . ARG A 1 279 ? -3.32537  -4.28984  28.62649  1.000 36.36306 ? 279 ARG A C    1 
ATOM   4164 O O    . ARG A 1 279 ? -3.85087  -4.42757  27.51122  1.000 39.98046 ? 279 ARG A O    1 
ATOM   4165 C CB   . ARG A 1 279 ? -3.84731  -2.66338  30.45231  1.000 39.11235 ? 279 ARG A CB   1 
ATOM   4166 C CG   . ARG A 1 279 ? -3.48858  -1.42359  31.26420  1.000 46.87729 ? 279 ARG A CG   1 
ATOM   4167 C CD   . ARG A 1 279 ? -3.62593  -1.65863  32.76901  1.000 49.11850 ? 279 ARG A CD   1 
ATOM   4168 N NE   . ARG A 1 279 ? -2.68532  -2.65720  33.28273  1.000 48.41058 ? 279 ARG A NE   1 
ATOM   4169 C CZ   . ARG A 1 279 ? -2.48257  -2.90583  34.57165  1.000 53.10043 ? 279 ARG A CZ   1 
ATOM   4170 N NH1  . ARG A 1 279 ? -3.12444  -2.22993  35.51584  1.000 47.08843 ? 279 ARG A NH1  1 
ATOM   4171 N NH2  . ARG A 1 279 ? -1.61594  -3.85936  34.92236  1.000 50.86423 ? 279 ARG A NH2  1 
ATOM   4172 H H    . ARG A 1 279 ? -4.07139  -1.57619  28.23390  1.000 49.81148 ? 279 ARG A H    1 
ATOM   4173 H HA   . ARG A 1 279 ? -2.07080  -2.86435  29.45681  1.000 42.48541 ? 279 ARG A HA   1 
ATOM   4174 H HB2  . ARG A 1 279 ? -4.77429  -2.56995  30.18104  1.000 46.93482 ? 279 ARG A HB2  1 
ATOM   4175 H HB3  . ARG A 1 279 ? -3.74891  -3.42866  31.03887  1.000 46.93482 ? 279 ARG A HB3  1 
ATOM   4176 H HG2  . ARG A 1 279 ? -2.56871  -1.17775  31.07968  1.000 56.25274 ? 279 ARG A HG2  1 
ATOM   4177 H HG3  . ARG A 1 279 ? -4.08207  -0.69791  31.01644  1.000 56.25274 ? 279 ARG A HG3  1 
ATOM   4178 H HD2  . ARG A 1 279 ? -3.45976  -0.82379  33.23458  1.000 58.94220 ? 279 ARG A HD2  1 
ATOM   4179 H HD3  . ARG A 1 279 ? -4.52475  -1.96946  32.95850  1.000 58.94220 ? 279 ARG A HD3  1 
ATOM   4180 H HE   . ARG A 1 279 ? -2.23275  -3.11349  32.71060  1.000 58.09270 ? 279 ARG A HE   1 
ATOM   4181 H HH11 . ARG A 1 279 ? -3.68686  -1.61624  35.29902  1.000 56.50612 ? 279 ARG A HH11 1 
ATOM   4182 H HH12 . ARG A 1 279 ? -2.97960  -2.40632  36.34478  1.000 56.50612 ? 279 ARG A HH12 1 
ATOM   4183 H HH21 . ARG A 1 279 ? -1.19737  -4.30365  34.31624  1.000 61.03707 ? 279 ARG A HH21 1 
ATOM   4184 H HH22 . ARG A 1 279 ? -1.47610  -4.02876  35.75431  1.000 61.03707 ? 279 ARG A HH22 1 
ATOM   4185 N N    . THR A 1 280 ? -3.04982  -5.32810  29.40995  1.000 38.86110 ? 280 THR A N    1 
ATOM   4186 C CA   . THR A 1 280 ? -3.42560  -6.67015  28.99099  1.000 32.38182 ? 280 THR A CA   1 
ATOM   4187 C C    . THR A 1 280 ? -4.16246  -7.35944  30.13231  1.000 27.32509 ? 280 THR A C    1 
ATOM   4188 O O    . THR A 1 280 ? -4.02116  -7.00105  31.30758  1.000 34.51134 ? 280 THR A O    1 
ATOM   4189 C CB   . THR A 1 280 ? -2.21780  -7.51795  28.61489  1.000 33.56843 ? 280 THR A CB   1 
ATOM   4190 O OG1  . THR A 1 280 ? -1.25027  -7.37782  29.64432  1.000 37.05661 ? 280 THR A OG1  1 
ATOM   4191 C CG2  . THR A 1 280 ? -1.64874  -7.00669  27.30441  1.000 30.85514 ? 280 THR A CG2  1 
ATOM   4192 H H    . THR A 1 280 ? -2.65513  -5.27926  30.17212  1.000 46.63333 ? 280 THR A H    1 
ATOM   4193 H HA   . THR A 1 280 ? -4.00739  -6.60213  28.21783  1.000 38.85818 ? 280 THR A HA   1 
ATOM   4194 H HB   . THR A 1 280 ? -2.45301  -8.45308  28.50823  1.000 40.28211 ? 280 THR A HB   1 
ATOM   4195 H HG1  . THR A 1 280 ? -1.14983  -8.10899  30.04591  1.000 44.46793 ? 280 THR A HG1  1 
ATOM   4196 H HG21 . THR A 1 280 ? -0.90919  -7.56693  27.02332  1.000 37.02616 ? 280 THR A HG21 1 
ATOM   4197 H HG22 . THR A 1 280 ? -2.33349  -7.01981  26.61816  1.000 37.02616 ? 280 THR A HG22 1 
ATOM   4198 H HG23 . THR A 1 280 ? -1.33050  -6.09651  27.41408  1.000 37.02616 ? 280 THR A HG23 1 
ATOM   4199 N N    . ILE A 1 281 ? -4.93552  -8.37683  29.76440  1.000 28.01961 ? 281 ILE A N    1 
ATOM   4200 C CA   . ILE A 1 281 ? -5.62914  -9.26795  30.68861  1.000 27.04224 ? 281 ILE A CA   1 
ATOM   4201 C C    . ILE A 1 281 ? -5.31785  -10.70646 30.29683  1.000 23.00963 ? 281 ILE A C    1 
ATOM   4202 O O    . ILE A 1 281 ? -5.61612  -11.13000 29.16947  1.000 26.73714 ? 281 ILE A O    1 
ATOM   4203 C CB   . ILE A 1 281 ? -7.15533  -9.03017  30.69822  1.000 19.57421 ? 281 ILE A CB   1 
ATOM   4204 C CG1  . ILE A 1 281 ? -7.49861  -7.58766  31.05799  1.000 27.21992 ? 281 ILE A CG1  1 
ATOM   4205 C CG2  . ILE A 1 281 ? -7.83783  -10.05126 31.58835  1.000 25.12036 ? 281 ILE A CG2  1 
ATOM   4206 C CD1  . ILE A 1 281 ? -8.99883  -7.35193  31.16860  1.000 23.66507 ? 281 ILE A CD1  1 
ATOM   4207 H H    . ILE A 1 281 ? -5.08107  -8.58043  28.94123  1.000 33.62353 ? 281 ILE A H    1 
ATOM   4208 H HA   . ILE A 1 281 ? -5.29358  -9.11223  31.58583  1.000 32.45069 ? 281 ILE A HA   1 
ATOM   4209 H HB   . ILE A 1 281 ? -7.49691  -9.15989  29.79902  1.000 23.48905 ? 281 ILE A HB   1 
ATOM   4210 H HG12 . ILE A 1 281 ? -7.09608  -7.37087  31.91326  1.000 32.66390 ? 281 ILE A HG12 1 
ATOM   4211 H HG13 . ILE A 1 281 ? -7.15183  -6.99996  30.36847  1.000 32.66390 ? 281 ILE A HG13 1 
ATOM   4212 H HG21 . ILE A 1 281 ? -8.79684  -9.98995  31.46205  1.000 30.14443 ? 281 ILE A HG21 1 
ATOM   4213 H HG22 . ILE A 1 281 ? -7.52804  -10.93887 31.34591  1.000 30.14443 ? 281 ILE A HG22 1 
ATOM   4214 H HG23 . ILE A 1 281 ? -7.61331  -9.86465  32.51254  1.000 30.14443 ? 281 ILE A HG23 1 
ATOM   4215 H HD11 . ILE A 1 281 ? -9.17855  -6.40400  31.06212  1.000 28.39808 ? 281 ILE A HD11 1 
ATOM   4216 H HD12 . ILE A 1 281 ? -9.45019  -7.85386  30.47213  1.000 28.39808 ? 281 ILE A HD12 1 
ATOM   4217 H HD13 . ILE A 1 281 ? -9.30190  -7.64970  32.04031  1.000 28.39808 ? 281 ILE A HD13 1 
ATOM   4218 N N    . LEU A 1 282 ? -4.75058  -11.47058 31.23256  1.000 28.98756 ? 282 LEU A N    1 
ATOM   4219 C CA   . LEU A 1 282 ? -4.25641  -12.80501 30.93991  1.000 26.92232 ? 282 LEU A CA   1 
ATOM   4220 C C    . LEU A 1 282 ? -3.50289  -12.87260 29.61614  1.000 28.08749 ? 282 LEU A C    1 
ATOM   4221 O O    . LEU A 1 282 ? -3.70486  -13.82328 28.84148  1.000 27.06933 ? 282 LEU A O    1 
ATOM   4222 C CB   . LEU A 1 282 ? -5.39959  -13.82791 30.91588  1.000 26.13746 ? 282 LEU A CB   1 
ATOM   4223 C CG   . LEU A 1 282 ? -6.11891  -14.01431 32.25751  1.000 28.93238 ? 282 LEU A CG   1 
ATOM   4224 C CD1  . LEU A 1 282 ? -7.38725  -14.80526 32.16858  1.000 29.05453 ? 282 LEU A CD1  1 
ATOM   4225 C CD2  . LEU A 1 282 ? -5.16269  -14.73516 33.24541  1.000 24.40906 ? 282 LEU A CD2  1 
ATOM   4226 H H    . LEU A 1 282 ? -4.64106  -11.23100 32.05075  1.000 34.78508 ? 282 LEU A H    1 
ATOM   4227 H HA   . LEU A 1 282 ? -3.63748  -13.03696 31.65099  1.000 32.30678 ? 282 LEU A HA   1 
ATOM   4228 H HB2  . LEU A 1 282 ? -6.05959  -13.53603 30.26683  1.000 31.36495 ? 282 LEU A HB2  1 
ATOM   4229 H HB3  . LEU A 1 282 ? -5.03681  -14.68846 30.65548  1.000 31.36495 ? 282 LEU A HB3  1 
ATOM   4230 H HG   . LEU A 1 282 ? -6.36673  -13.12970 32.56997  1.000 34.71885 ? 282 LEU A HG   1 
ATOM   4231 H HD11 . LEU A 1 282 ? -7.77250  -14.88412 33.05539  1.000 34.86544 ? 282 LEU A HD11 1 
ATOM   4232 H HD12 . LEU A 1 282 ? -8.00441  -14.34539 31.57864  1.000 34.86544 ? 282 LEU A HD12 1 
ATOM   4233 H HD13 . LEU A 1 282 ? -7.18543  -15.68589 31.81610  1.000 34.86544 ? 282 LEU A HD13 1 
ATOM   4234 H HD21 . LEU A 1 282 ? -5.68166  -15.09802 33.98000  1.000 29.29087 ? 282 LEU A HD21 1 
ATOM   4235 H HD22 . LEU A 1 282 ? -4.70695  -15.45250 32.77712  1.000 29.29087 ? 282 LEU A HD22 1 
ATOM   4236 H HD23 . LEU A 1 282 ? -4.51532  -14.09585 33.58203  1.000 29.29087 ? 282 LEU A HD23 1 
ATOM   4237 N N    . GLY A 1 283 ? -2.63759  -11.88876 29.37205  1.000 26.27083 ? 283 GLY A N    1 
ATOM   4238 C CA   . GLY A 1 283 ? -1.81318  -11.86036 28.16936  1.000 28.49719 ? 283 GLY A CA   1 
ATOM   4239 C C    . GLY A 1 283 ? -2.53402  -11.49815 26.90133  1.000 30.98637 ? 283 GLY A C    1 
ATOM   4240 O O    . GLY A 1 283 ? -1.93656  -11.59701 25.82248  1.000 36.38648 ? 283 GLY A O    1 
ATOM   4241 H H    . GLY A 1 283 ? -2.50930  -11.21798 29.89451  1.000 31.52500 ? 283 GLY A H    1 
ATOM   4242 H HA2  . GLY A 1 283 ? -1.10274  -11.21187 28.29801  1.000 34.19662 ? 283 GLY A HA2  1 
ATOM   4243 H HA3  . GLY A 1 283 ? -1.42044  -12.73797 28.04396  1.000 34.19662 ? 283 GLY A HA3  1 
ATOM   4244 N N    . SER A 1 284 ? -3.79239  -11.07620 26.97514  1.000 30.58411 ? 284 SER A N    1 
ATOM   4245 C CA   . SER A 1 284 ? -4.52832  -10.63806 25.79515  1.000 22.15664 ? 284 SER A CA   1 
ATOM   4246 C C    . SER A 1 284 ? -4.81454  -9.14134  25.88098  1.000 28.94000 ? 284 SER A C    1 
ATOM   4247 O O    . SER A 1 284 ? -5.18132  -8.62428  26.93916  1.000 27.32353 ? 284 SER A O    1 
ATOM   4248 C CB   . SER A 1 284 ? -5.83264  -11.41399 25.62821  1.000 20.53369 ? 284 SER A CB   1 
ATOM   4249 O OG   . SER A 1 284 ? -6.52158  -10.96982 24.46124  1.000 25.65660 ? 284 SER A OG   1 
ATOM   4250 H H    . SER A 1 284 ? -4.24568  -11.03401 27.70501  1.000 36.70094 ? 284 SER A H    1 
ATOM   4251 H HA   . SER A 1 284 ? -3.98491  -10.79714 25.00725  1.000 26.58797 ? 284 SER A HA   1 
ATOM   4252 H HB2  . SER A 1 284 ? -5.63286  -12.35878 25.53970  1.000 24.64043 ? 284 SER A HB2  1 
ATOM   4253 H HB3  . SER A 1 284 ? -6.39404  -11.26392 26.40511  1.000 24.64043 ? 284 SER A HB3  1 
ATOM   4254 H HG   . SER A 1 284 ? -7.09811  -10.39541 24.66840  1.000 30.78792 ? 284 SER A HG   1 
ATOM   4255 N N    . ALA A 1 285 ? -4.63068  -8.45749  24.75246  1.000 27.24492 ? 285 ALA A N    1 
ATOM   4256 C CA   . ALA A 1 285 ? -4.95874  -7.05464  24.56821  1.000 22.59480 ? 285 ALA A CA   1 
ATOM   4257 C C    . ALA A 1 285 ? -6.37570  -6.87044  24.04182  1.000 26.01554 ? 285 ALA A C    1 
ATOM   4258 O O    . ALA A 1 285 ? -6.78150  -5.73660  23.76538  1.000 31.41125 ? 285 ALA A O    1 
ATOM   4259 C CB   . ALA A 1 285 ? -3.93490  -6.42524  23.62296  1.000 32.73761 ? 285 ALA A CB   1 
ATOM   4260 H H    . ALA A 1 285 ? -4.29715  -8.80879  24.04236  1.000 32.69390 ? 285 ALA A H    1 
ATOM   4261 H HA   . ALA A 1 285 ? -4.90241  -6.57812  25.41052  1.000 27.11376 ? 285 ALA A HA   1 
ATOM   4262 H HB1  . ALA A 1 285 ? -4.27148  -5.56732  23.31937  1.000 39.28513 ? 285 ALA A HB1  1 
ATOM   4263 H HB2  . ALA A 1 285 ? -3.09917  -6.30387  24.09833  1.000 39.28513 ? 285 ALA A HB2  1 
ATOM   4264 H HB3  . ALA A 1 285 ? -3.80117  -7.01467  22.86464  1.000 39.28513 ? 285 ALA A HB3  1 
ATOM   4265 N N    . LEU A 1 286 ? -7.10376  -7.96290  23.84589  1.000 22.92677 ? 286 LEU A N    1 
ATOM   4266 C CA   . LEU A 1 286 ? -8.49864  -7.95179  23.47841  1.000 24.05992 ? 286 LEU A CA   1 
ATOM   4267 C C    . LEU A 1 286 ? -9.30240  -8.71707  24.51965  1.000 23.03238 ? 286 LEU A C    1 
ATOM   4268 O O    . LEU A 1 286 ? -8.75610  -9.46215  25.35139  1.000 23.39387 ? 286 LEU A O    1 
ATOM   4269 C CB   . LEU A 1 286 ? -8.70964  -8.59611  22.10394  1.000 26.35162 ? 286 LEU A CB   1 
ATOM   4270 C CG   . LEU A 1 286 ? -8.02973  -7.94983  20.89957  1.000 30.44157 ? 286 LEU A CG   1 
ATOM   4271 C CD1  . LEU A 1 286 ? -8.25655  -8.88826  19.68591  1.000 33.54445 ? 286 LEU A CD1  1 
ATOM   4272 C CD2  . LEU A 1 286 ? -8.51175  -6.55905  20.64326  1.000 35.70964 ? 286 LEU A CD2  1 
ATOM   4273 H H    . LEU A 1 286 ? -6.78915  -8.75870  23.92651  1.000 27.51213 ? 286 LEU A H    1 
ATOM   4274 H HA   . LEU A 1 286 ? -8.81136  -7.03402  23.44486  1.000 28.87191 ? 286 LEU A HA   1 
ATOM   4275 H HB2  . LEU A 1 286 ? -8.38193  -9.50888  22.15249  1.000 31.62194 ? 286 LEU A HB2  1 
ATOM   4276 H HB3  . LEU A 1 286 ? -9.66258  -8.59576  21.92060  1.000 31.62194 ? 286 LEU A HB3  1 
ATOM   4277 H HG   . LEU A 1 286 ? -7.07987  -7.84517  21.06197  1.000 36.52988 ? 286 LEU A HG   1 
ATOM   4278 H HD11 . LEU A 1 286 ? -7.79957  -8.52042  18.91330  1.000 40.25334 ? 286 LEU A HD11 1 
ATOM   4279 H HD12 . LEU A 1 286 ? -7.90093  -9.76610  19.89450  1.000 40.25334 ? 286 LEU A HD12 1 
ATOM   4280 H HD13 . LEU A 1 286 ? -9.20844  -8.95091  19.50854  1.000 40.25334 ? 286 LEU A HD13 1 
ATOM   4281 H HD21 . LEU A 1 286 ? -8.02477  -6.19020  19.88966  1.000 42.85157 ? 286 LEU A HD21 1 
ATOM   4282 H HD22 . LEU A 1 286 ? -9.46065  -6.58468  20.44291  1.000 42.85157 ? 286 LEU A HD22 1 
ATOM   4283 H HD23 . LEU A 1 286 ? -8.35545  -6.01941  21.43465  1.000 42.85157 ? 286 LEU A HD23 1 
ATOM   4284 N N    . LEU A 1 287 ? -10.61851 -8.54408  24.45429  1.000 16.59718 ? 287 LEU A N    1 
ATOM   4285 C CA   . LEU A 1 287 ? -11.51822 -9.29632  25.30551  1.000 24.53431 ? 287 LEU A CA   1 
ATOM   4286 C C    . LEU A 1 287 ? -11.78391 -10.65714 24.67258  1.000 24.80589 ? 287 LEU A C    1 
ATOM   4287 O O    . LEU A 1 287 ? -12.23743 -10.75480 23.53736  1.000 22.89581 ? 287 LEU A O    1 
ATOM   4288 C CB   . LEU A 1 287 ? -12.79793 -8.50148  25.54055  1.000 28.18604 ? 287 LEU A CB   1 
ATOM   4289 C CG   . LEU A 1 287 ? -12.43523 -7.13457  26.14952  1.000 27.16876 ? 287 LEU A CG   1 
ATOM   4290 C CD1  . LEU A 1 287 ? -13.60500 -6.19554  26.21269  1.000 31.20644 ? 287 LEU A CD1  1 
ATOM   4291 C CD2  . LEU A 1 287 ? -11.78960 -7.29692  27.54665  1.000 33.20065 ? 287 LEU A CD2  1 
ATOM   4292 H H    . LEU A 1 287 ? -11.01176 -7.99406  23.92350  1.000 19.91662 ? 287 LEU A H    1 
ATOM   4293 H HA   . LEU A 1 287 ? -11.11640 -9.45353  26.17356  1.000 29.44117 ? 287 LEU A HA   1 
ATOM   4294 H HB2  . LEU A 1 287 ? -13.25875 -8.36033  24.69848  1.000 33.82325 ? 287 LEU A HB2  1 
ATOM   4295 H HB3  . LEU A 1 287 ? -13.37377 -8.97932  26.15805  1.000 33.82325 ? 287 LEU A HB3  1 
ATOM   4296 H HG   . LEU A 1 287 ? -11.78335 -6.72668  25.55800  1.000 32.60251 ? 287 LEU A HG   1 
ATOM   4297 H HD11 . LEU A 1 287 ? -13.32081 -5.36356  26.62030  1.000 37.44773 ? 287 LEU A HD11 1 
ATOM   4298 H HD12 . LEU A 1 287 ? -13.92582 -6.03024  25.31268  1.000 37.44773 ? 287 LEU A HD12 1 
ATOM   4299 H HD13 . LEU A 1 287 ? -14.30687 -6.60142  26.74419  1.000 37.44773 ? 287 LEU A HD13 1 
ATOM   4300 H HD21 . LEU A 1 287 ? -11.68844 -6.42108  27.95123  1.000 39.84078 ? 287 LEU A HD21 1 
ATOM   4301 H HD22 . LEU A 1 287 ? -12.36335 -7.85071  28.09811  1.000 39.84078 ? 287 LEU A HD22 1 
ATOM   4302 H HD23 . LEU A 1 287 ? -10.92123 -7.71716  27.44670  1.000 39.84078 ? 287 LEU A HD23 1 
ATOM   4303 N N    . GLU A 1 288 ? -11.46435 -11.68834 25.41006  1.000 21.31302 ? 288 GLU A N    1 
ATOM   4304 C CA   A GLU A 1 288 ? -11.51409 -13.06710 24.95819  0.500 22.05087 ? 288 GLU A CA   1 
ATOM   4305 C CA   B GLU A 1 288 ? -11.51509 -13.05809 24.93820  0.500 21.66086 ? 288 GLU A CA   1 
ATOM   4306 C C    . GLU A 1 288 ? -12.88872 -13.65937 25.23434  1.000 23.80836 ? 288 GLU A C    1 
ATOM   4307 O O    . GLU A 1 288 ? -13.38417 -13.60247 26.37520  1.000 19.98366 ? 288 GLU A O    1 
ATOM   4308 C CB   A GLU A 1 288 ? -10.43970 -13.87870 25.68607  0.500 22.08936 ? 288 GLU A CB   1 
ATOM   4309 C CB   B GLU A 1 288 ? -10.37469 -13.84758 25.58111  0.500 22.17841 ? 288 GLU A CB   1 
ATOM   4310 C CG   A GLU A 1 288 ? -10.48244 -15.35358 25.43314  0.500 24.25314 ? 288 GLU A CG   1 
ATOM   4311 C CG   B GLU A 1 288 ? -8.94492  -13.37119 25.17191  0.500 24.14512 ? 288 GLU A CG   1 
ATOM   4312 C CD   A GLU A 1 288 ? -10.03163 -15.75837 24.05605  0.500 23.92874 ? 288 GLU A CD   1 
ATOM   4313 C CD   B GLU A 1 288 ? -8.62634  -13.43902 23.67698  0.500 27.73686 ? 288 GLU A CD   1 
ATOM   4314 O OE1  A GLU A 1 288 ? -8.95082  -15.31623 23.59671  0.500 22.59107 ? 288 GLU A OE1  1 
ATOM   4315 O OE1  B GLU A 1 288 ? -9.02432  -14.42393 23.01923  0.500 26.96321 ? 288 GLU A OE1  1 
ATOM   4316 O OE2  A GLU A 1 288 ? -10.77381 -16.49856 23.40734  0.500 21.33736 ? 288 GLU A OE2  1 
ATOM   4317 O OE2  B GLU A 1 288 ? -7.92487  -12.54314 23.16078  0.500 31.76796 ? 288 GLU A OE2  1 
ATOM   4318 H H    . GLU A 1 288 ? -11.20269 -11.62364 26.22719  1.000 25.57563 ? 288 GLU A H    1 
ATOM   4319 H HA   . GLU A 1 288 ? -11.35772 -13.10639 24.00122  1.000 25.99303 ? 288 GLU A HA   1 
ATOM   4320 H HB2  A GLU A 1 288 ? -9.56885  -13.56083 25.40157  0.500 26.50724 ? 288 GLU A HB2  1 
ATOM   4321 H HB2  B GLU A 1 288 ? -10.44610 -13.76423 26.54514  0.500 26.61409 ? 288 GLU A HB2  1 
ATOM   4322 H HB3  A GLU A 1 288 ? -10.54615 -13.74437 26.64011  0.500 26.50724 ? 288 GLU A HB3  1 
ATOM   4323 H HB3  B GLU A 1 288 ? -10.45886 -14.77849 25.32151  0.500 26.61409 ? 288 GLU A HB3  1 
ATOM   4324 H HG2  A GLU A 1 288 ? -9.90231  -15.79451 26.07308  0.500 29.10377 ? 288 GLU A HG2  1 
ATOM   4325 H HG2  B GLU A 1 288 ? -8.84176  -12.44628 25.44652  0.500 28.97415 ? 288 GLU A HG2  1 
ATOM   4326 H HG3  A GLU A 1 288 ? -11.39523 -15.66037 25.54563  0.500 29.10377 ? 288 GLU A HG3  1 
ATOM   4327 H HG3  B GLU A 1 288 ? -8.29564  -13.92796 25.62980  0.500 28.97415 ? 288 GLU A HG3  1 
ATOM   4328 N N    . ASP A 1 289 ? -13.51690 -14.23123 24.20077  1.000 22.60025 ? 289 ASP A N    1 
ATOM   4329 C CA   . ASP A 1 289 ? -14.83347 -14.84438 24.36892  1.000 27.61330 ? 289 ASP A CA   1 
ATOM   4330 C C    . ASP A 1 289 ? -14.86616 -16.31918 23.99700  1.000 25.57269 ? 289 ASP A C    1 
ATOM   4331 O O    . ASP A 1 289 ? -15.94365 -16.88793 23.81427  1.000 17.97786 ? 289 ASP A O    1 
ATOM   4332 C CB   . ASP A 1 289 ? -15.90382 -14.06276 23.59103  1.000 23.76603 ? 289 ASP A CB   1 
ATOM   4333 C CG   . ASP A 1 289 ? -15.94404 -14.35184 22.05283  1.000 30.95408 ? 289 ASP A CG   1 
ATOM   4334 O OD1  . ASP A 1 289 ? -14.95543 -14.85469 21.45887  1.000 22.55398 ? 289 ASP A OD1  1 
ATOM   4335 O OD2  . ASP A 1 289 ? -16.97216 -13.94129 21.45972  1.000 23.68226 ? 289 ASP A OD2  1 
ATOM   4336 H H    . ASP A 1 289 ? -13.20058 -14.27549 23.40285  1.000 27.12030 ? 289 ASP A H    1 
ATOM   4337 H HA   . ASP A 1 289 ? -15.05784 -14.79614 25.31087  1.000 33.13596 ? 289 ASP A HA   1 
ATOM   4338 H HB2  . ASP A 1 289 ? -16.77476 -14.28967 23.95258  1.000 28.51924 ? 289 ASP A HB2  1 
ATOM   4339 H HB3  . ASP A 1 289 ? -15.73461 -13.11369 23.70367  1.000 28.51924 ? 289 ASP A HB3  1 
ATOM   4340 N N    . GLU A 1 290 ? -13.71862 -16.97924 23.95800  1.000 22.43140 ? 290 GLU A N    1 
ATOM   4341 C CA   . GLU A 1 290 ? -13.69438 -18.39202 23.62314  1.000 23.60818 ? 290 GLU A CA   1 
ATOM   4342 C C    . GLU A 1 290 ? -13.53209 -19.29963 24.82964  1.000 24.44018 ? 290 GLU A C    1 
ATOM   4343 O O    . GLU A 1 290 ? -13.21308 -20.48628 24.66902  1.000 23.06856 ? 290 GLU A O    1 
ATOM   4344 C CB   . GLU A 1 290 ? -12.59279 -18.68452 22.61735  1.000 31.28272 ? 290 GLU A CB   1 
ATOM   4345 C CG   . GLU A 1 290 ? -12.94262 -18.29296 21.24746  1.000 29.60020 ? 290 GLU A CG   1 
ATOM   4346 C CD   . GLU A 1 290 ? -12.14209 -19.08111 20.22875  1.000 42.53542 ? 290 GLU A CD   1 
ATOM   4347 O OE1  . GLU A 1 290 ? -10.91238 -19.32946 20.42282  1.000 33.36593 ? 290 GLU A OE1  1 
ATOM   4348 O OE2  . GLU A 1 290 ? -12.76527 -19.47587 19.23558  1.000 26.50464 ? 290 GLU A OE2  1 
ATOM   4349 H H    . GLU A 1 290 ? -12.94796 -16.63273 24.11949  1.000 26.91768 ? 290 GLU A H    1 
ATOM   4350 H HA   . GLU A 1 290 ? -14.55007 -18.59945 23.21571  1.000 28.32981 ? 290 GLU A HA   1 
ATOM   4351 H HB2  . GLU A 1 290 ? -11.79627 -18.19605 22.87293  1.000 37.53926 ? 290 GLU A HB2  1 
ATOM   4352 H HB3  . GLU A 1 290 ? -12.41203 -19.63738 22.61782  1.000 37.53926 ? 290 GLU A HB3  1 
ATOM   4353 H HG2  . GLU A 1 290 ? -13.88503 -18.46293 21.09414  1.000 35.52024 ? 290 GLU A HG2  1 
ATOM   4354 H HG3  . GLU A 1 290 ? -12.75051 -17.35026 21.12332  1.000 35.52024 ? 290 GLU A HG3  1 
ATOM   4355 N N    . PHE A 1 291 ? -13.81391 -18.80160 26.03584  1.000 18.03373 ? 291 PHE A N    1 
ATOM   4356 C CA   . PHE A 1 291 ? -13.94962 -19.67541 27.17626  1.000 20.22692 ? 291 PHE A CA   1 
ATOM   4357 C C    . PHE A 1 291 ? -15.34987 -19.60488 27.74781  1.000 18.04980 ? 291 PHE A C    1 
ATOM   4358 O O    . PHE A 1 291 ? -15.82886 -18.51246 28.07731  1.000 20.17527 ? 291 PHE A O    1 
ATOM   4359 C CB   . PHE A 1 291 ? -12.99631 -19.30035 28.29882  1.000 24.26257 ? 291 PHE A CB   1 
ATOM   4360 C CG   . PHE A 1 291 ? -11.56308 -19.42999 27.94325  1.000 24.77835 ? 291 PHE A CG   1 
ATOM   4361 C CD1  . PHE A 1 291 ? -10.92515 -20.64455 28.05273  1.000 22.60883 ? 291 PHE A CD1  1 
ATOM   4362 C CD2  . PHE A 1 291 ? -10.85581 -18.33216 27.52018  1.000 26.12787 ? 291 PHE A CD2  1 
ATOM   4363 C CE1  . PHE A 1 291 ? -9.59197  -20.73329 27.73414  1.000 29.38868 ? 291 PHE A CE1  1 
ATOM   4364 C CE2  . PHE A 1 291 ? -9.52362  -18.42892 27.22559  1.000 33.23072 ? 291 PHE A CE2  1 
ATOM   4365 C CZ   . PHE A 1 291 ? -8.90770  -19.62849 27.32806  1.000 25.50144 ? 291 PHE A CZ   1 
ATOM   4366 H H    . PHE A 1 291 ? -13.92863 -17.96680 26.20432  1.000 21.64048 ? 291 PHE A H    1 
ATOM   4367 H HA   . PHE A 1 291 ? -13.76679 -20.57407 26.86077  1.000 24.27231 ? 291 PHE A HA   1 
ATOM   4368 H HB2  . PHE A 1 291 ? -13.15613 -18.37563 28.54634  1.000 29.11508 ? 291 PHE A HB2  1 
ATOM   4369 H HB3  . PHE A 1 291 ? -13.16612 -19.88095 29.05741  1.000 29.11508 ? 291 PHE A HB3  1 
ATOM   4370 H HD1  . PHE A 1 291 ? -11.39166 -21.39609 28.33910  1.000 27.13060 ? 291 PHE A HD1  1 
ATOM   4371 H HD2  . PHE A 1 291 ? -11.28743 -17.51245 27.43353  1.000 31.35345 ? 291 PHE A HD2  1 
ATOM   4372 H HE1  . PHE A 1 291 ? -9.15534  -21.55198 27.79679  1.000 35.26642 ? 291 PHE A HE1  1 
ATOM   4373 H HE2  . PHE A 1 291 ? -9.04713  -17.67737 26.95822  1.000 39.87687 ? 291 PHE A HE2  1 
ATOM   4374 H HZ   . PHE A 1 291 ? -8.00457  -19.69964 27.11834  1.000 30.60173 ? 291 PHE A HZ   1 
ATOM   4375 N N    . THR A 1 292 ? -15.98002 -20.75248 27.91088  1.000 15.03895 ? 292 THR A N    1 
ATOM   4376 C CA   . THR A 1 292 ? -17.25325 -20.77092 28.59342  1.000 16.74144 ? 292 THR A CA   1 
ATOM   4377 C C    . THR A 1 292 ? -17.04676 -20.78768 30.09848  1.000 21.78059 ? 292 THR A C    1 
ATOM   4378 O O    . THR A 1 292 ? -15.98563 -21.17614 30.58561  1.000 23.45259 ? 292 THR A O    1 
ATOM   4379 C CB   . THR A 1 292 ? -18.06215 -21.99134 28.23438  1.000 24.31124 ? 292 THR A CB   1 
ATOM   4380 O OG1  . THR A 1 292 ? -17.33236 -23.14700 28.62092  1.000 25.66610 ? 292 THR A OG1  1 
ATOM   4381 C CG2  . THR A 1 292 ? -18.34461 -22.01666 26.75926  1.000 22.53223 ? 292 THR A CG2  1 
ATOM   4382 H H    . THR A 1 292 ? -15.69531 -21.51709 27.64051  1.000 18.04674 ? 292 THR A H    1 
ATOM   4383 H HA   . THR A 1 292 ? -17.74378 -19.98014 28.32173  1.000 20.08973 ? 292 THR A HA   1 
ATOM   4384 H HB   . THR A 1 292 ? -18.91732 -21.98330 28.69308  1.000 29.17349 ? 292 THR A HB   1 
ATOM   4385 H HG1  . THR A 1 292 ? -17.85700 -23.73560 28.91137  1.000 30.79932 ? 292 THR A HG1  1 
ATOM   4386 H HG21 . THR A 1 292 ? -18.88291 -22.79295 26.53759  1.000 27.03868 ? 292 THR A HG21 1 
ATOM   4387 H HG22 . THR A 1 292 ? -18.82615 -21.21588 26.50059  1.000 27.03868 ? 292 THR A HG22 1 
ATOM   4388 H HG23 . THR A 1 292 ? -17.51240 -22.05869 26.26353  1.000 27.03868 ? 292 THR A HG23 1 
ATOM   4389 N N    . PRO A 1 293 ? -18.07730 -20.44897 30.85232  1.000 25.45931 ? 293 PRO A N    1 
ATOM   4390 C CA   . PRO A 1 293 ? -18.00667 -20.63481 32.31523  1.000 20.93169 ? 293 PRO A CA   1 
ATOM   4391 C C    . PRO A 1 293 ? -17.58069 -22.04372 32.71552  1.000 26.98576 ? 293 PRO A C    1 
ATOM   4392 O O    . PRO A 1 293 ? -16.79291 -22.18667 33.65271  1.000 23.92056 ? 293 PRO A O    1 
ATOM   4393 C CB   . PRO A 1 293 ? -19.43011 -20.28722 32.76995  1.000 21.50407 ? 293 PRO A CB   1 
ATOM   4394 C CG   . PRO A 1 293 ? -19.96246 -19.35596 31.65933  1.000 22.38358 ? 293 PRO A CG   1 
ATOM   4395 C CD   . PRO A 1 293 ? -19.36957 -19.90571 30.39020  1.000 26.73812 ? 293 PRO A CD   1 
ATOM   4396 H HA   . PRO A 1 293 ? -17.39232 -19.99757 32.71284  1.000 25.11803 ? 293 PRO A HA   1 
ATOM   4397 H HB2  . PRO A 1 293 ? -19.96549 -21.09369 32.83826  1.000 25.80489 ? 293 PRO A HB2  1 
ATOM   4398 H HB3  . PRO A 1 293 ? -19.40577 -19.83273 33.62724  1.000 25.80489 ? 293 PRO A HB3  1 
ATOM   4399 H HG2  . PRO A 1 293 ? -20.93142 -19.38872 31.63397  1.000 26.86029 ? 293 PRO A HG2  1 
ATOM   4400 H HG3  . PRO A 1 293 ? -19.66524 -18.44682 31.81800  1.000 26.86029 ? 293 PRO A HG3  1 
ATOM   4401 H HD2  . PRO A 1 293 ? -19.92888 -20.60493 30.01957  1.000 32.08574 ? 293 PRO A HD2  1 
ATOM   4402 H HD3  . PRO A 1 293 ? -19.23790 -19.20320 29.73468  1.000 32.08574 ? 293 PRO A HD3  1 
ATOM   4403 N N    . PHE A 1 294 ? -18.04361 -23.08766 32.02071  1.000 28.64681 ? 294 PHE A N    1 
ATOM   4404 C CA   . PHE A 1 294 ? -17.55165 -24.42946 32.32506  1.000 30.17881 ? 294 PHE A CA   1 
ATOM   4405 C C    . PHE A 1 294 ? -16.06441 -24.57105 31.96549  1.000 26.88297 ? 294 PHE A C    1 
ATOM   4406 O O    . PHE A 1 294 ? -15.29719 -25.18290 32.71739  1.000 29.47110 ? 294 PHE A O    1 
ATOM   4407 C CB   . PHE A 1 294 ? -18.39856 -25.48869 31.61310  1.000 36.00554 ? 294 PHE A CB   1 
ATOM   4408 C CG   . PHE A 1 294 ? -19.68254 -25.83717 32.34744  1.000 50.48101 ? 294 PHE A CG   1 
ATOM   4409 C CD1  . PHE A 1 294 ? -19.88953 -25.44490 33.66222  1.000 53.68745 ? 294 PHE A CD1  1 
ATOM   4410 C CD2  . PHE A 1 294 ? -20.69386 -26.52288 31.71327  1.000 55.48726 ? 294 PHE A CD2  1 
ATOM   4411 C CE1  . PHE A 1 294 ? -21.05698 -25.75547 34.34019  1.000 59.98515 ? 294 PHE A CE1  1 
ATOM   4412 C CE2  . PHE A 1 294 ? -21.87661 -26.82365 32.38317  1.000 59.81164 ? 294 PHE A CE2  1 
ATOM   4413 C CZ   . PHE A 1 294 ? -22.04989 -26.44696 33.69882  1.000 62.89735 ? 294 PHE A CZ   1 
ATOM   4414 H H    . PHE A 1 294 ? -18.62542 -23.04573 31.38953  1.000 34.37617 ? 294 PHE A H    1 
ATOM   4415 H HA   . PHE A 1 294 ? -17.64186 -24.58612 33.27793  1.000 36.21457 ? 294 PHE A HA   1 
ATOM   4416 H HB2  . PHE A 1 294 ? -18.64051 -25.15534 30.73422  1.000 43.20665 ? 294 PHE A HB2  1 
ATOM   4417 H HB3  . PHE A 1 294 ? -17.87588 -26.30122 31.52779  1.000 43.20665 ? 294 PHE A HB3  1 
ATOM   4418 H HD1  . PHE A 1 294 ? -19.22712 -24.96015 34.09877  1.000 64.42494 ? 294 PHE A HD1  1 
ATOM   4419 H HD2  . PHE A 1 294 ? -20.58558 -26.78828 30.82836  1.000 66.58471 ? 294 PHE A HD2  1 
ATOM   4420 H HE1  . PHE A 1 294 ? -21.16499 -25.49698 35.22661  1.000 71.98218 ? 294 PHE A HE1  1 
ATOM   4421 H HE2  . PHE A 1 294 ? -22.55404 -27.28241 31.94038  1.000 71.77397 ? 294 PHE A HE2  1 
ATOM   4422 H HZ   . PHE A 1 294 ? -22.83688 -26.65997 34.14737  1.000 75.47681 ? 294 PHE A HZ   1 
ATOM   4423 N N    . ASP A 1 295 ? -15.61647 -23.99601 30.84801  1.000 26.74073 ? 295 ASP A N    1 
ATOM   4424 C CA   . ASP A 1 295 ? -14.19529 -24.08367 30.51445  1.000 25.09147 ? 295 ASP A CA   1 
ATOM   4425 C C    . ASP A 1 295 ? -13.33612 -23.54469 31.66609  1.000 36.54811 ? 295 ASP A C    1 
ATOM   4426 O O    . ASP A 1 295 ? -12.30778 -24.13610 32.02609  1.000 34.47526 ? 295 ASP A O    1 
ATOM   4427 C CB   . ASP A 1 295 ? -13.85645 -23.31861 29.24104  1.000 24.87044 ? 295 ASP A CB   1 
ATOM   4428 C CG   . ASP A 1 295 ? -14.45750 -23.95433 27.99944  1.000 28.27396 ? 295 ASP A CG   1 
ATOM   4429 O OD1  . ASP A 1 295 ? -14.86162 -25.12473 28.13057  1.000 30.91972 ? 295 ASP A OD1  1 
ATOM   4430 O OD2  . ASP A 1 295 ? -14.46161 -23.32965 26.89782  1.000 27.46049 ? 295 ASP A OD2  1 
ATOM   4431 H H    . ASP A 1 295 ? -16.09962 -23.56204 30.28410  1.000 32.08887 ? 295 ASP A H    1 
ATOM   4432 H HA   . ASP A 1 295 ? -13.99749 -25.01941 30.35395  1.000 30.10977 ? 295 ASP A HA   1 
ATOM   4433 H HB2  . ASP A 1 295 ? -14.20219 -22.41493 29.31348  1.000 29.84453 ? 295 ASP A HB2  1 
ATOM   4434 H HB3  . ASP A 1 295 ? -12.89342 -23.29678 29.13140  1.000 29.84453 ? 295 ASP A HB3  1 
ATOM   4435 N N    . VAL A 1 296 ? -13.73523 -22.40036 32.23265  1.000 28.46567 ? 296 VAL A N    1 
ATOM   4436 C CA   . VAL A 1 296 ? -12.94913 -21.74138 33.27434  1.000 25.51879 ? 296 VAL A CA   1 
ATOM   4437 C C    . VAL A 1 296 ? -12.91190 -22.59013 34.54083  1.000 31.91706 ? 296 VAL A C    1 
ATOM   4438 O O    . VAL A 1 296 ? -11.87403 -22.70870 35.19412  1.000 32.70199 ? 296 VAL A O    1 
ATOM   4439 C CB   . VAL A 1 296 ? -13.52135 -20.33801 33.56900  1.000 25.53848 ? 296 VAL A CB   1 
ATOM   4440 C CG1  . VAL A 1 296 ? -12.85028 -19.72225 34.82062  1.000 32.91025 ? 296 VAL A CG1  1 
ATOM   4441 C CG2  . VAL A 1 296 ? -13.34867 -19.40814 32.37763  1.000 23.08246 ? 296 VAL A CG2  1 
ATOM   4442 H H    . VAL A 1 296 ? -14.46049 -21.98481 32.03065  1.000 34.15881 ? 296 VAL A H    1 
ATOM   4443 H HA   . VAL A 1 296 ? -12.04109 -21.64345 32.94972  1.000 30.62255 ? 296 VAL A HA   1 
ATOM   4444 H HB   . VAL A 1 296 ? -14.47133 -20.43487 33.73961  1.000 30.64617 ? 296 VAL A HB   1 
ATOM   4445 H HG11 . VAL A 1 296 ? -13.12305 -18.79552 34.90109  1.000 39.49230 ? 296 VAL A HG11 1 
ATOM   4446 H HG12 . VAL A 1 296 ? -13.12916 -20.21996 35.60521  1.000 39.49230 ? 296 VAL A HG12 1 
ATOM   4447 H HG13 . VAL A 1 296 ? -11.88620 -19.77642 34.72092  1.000 39.49230 ? 296 VAL A HG13 1 
ATOM   4448 H HG21 . VAL A 1 296 ? -13.69544 -18.53256 32.60805  1.000 27.69895 ? 296 VAL A HG21 1 
ATOM   4449 H HG22 . VAL A 1 296 ? -12.40564 -19.34426 32.16101  1.000 27.69895 ? 296 VAL A HG22 1 
ATOM   4450 H HG23 . VAL A 1 296 ? -13.83811 -19.76906 31.62124  1.000 27.69895 ? 296 VAL A HG23 1 
ATOM   4451 N N    . VAL A 1 297 ? -14.05260 -23.14328 34.93308  1.000 32.07907 ? 297 VAL A N    1 
ATOM   4452 C CA   . VAL A 1 297 ? -14.10036 -23.97106 36.13356  1.000 34.60501 ? 297 VAL A CA   1 
ATOM   4453 C C    . VAL A 1 297 ? -13.26629 -25.23728 35.95707  1.000 41.55365 ? 297 VAL A C    1 
ATOM   4454 O O    . VAL A 1 297 ? -12.52930 -25.63526 36.86609  1.000 37.52071 ? 297 VAL A O    1 
ATOM   4455 C CB   . VAL A 1 297 ? -15.56222 -24.30144 36.48284  1.000 31.41430 ? 297 VAL A CB   1 
ATOM   4456 C CG1  . VAL A 1 297 ? -15.65577 -25.62723 37.23594  1.000 43.95023 ? 297 VAL A CG1  1 
ATOM   4457 C CG2  . VAL A 1 297 ? -16.20626 -23.20524 37.31647  1.000 34.11991 ? 297 VAL A CG2  1 
ATOM   4458 H H    . VAL A 1 297 ? -14.80552 -23.05763 34.52687  1.000 38.49489 ? 297 VAL A H    1 
ATOM   4459 H HA   . VAL A 1 297 ? -13.71402 -23.46920 36.86800  1.000 41.52602 ? 297 VAL A HA   1 
ATOM   4460 H HB   . VAL A 1 297 ? -16.04843 -24.37276 35.64646  1.000 37.69716 ? 297 VAL A HB   1 
ATOM   4461 H HG11 . VAL A 1 297 ? -16.50629 -25.66734 37.70114  1.000 52.74028 ? 297 VAL A HG11 1 
ATOM   4462 H HG12 . VAL A 1 297 ? -15.59246 -26.35713 36.59916  1.000 52.74028 ? 297 VAL A HG12 1 
ATOM   4463 H HG13 . VAL A 1 297 ? -14.92778 -25.68059 37.87374  1.000 52.74028 ? 297 VAL A HG13 1 
ATOM   4464 H HG21 . VAL A 1 297 ? -17.06808 -23.51490 37.63513  1.000 40.94389 ? 297 VAL A HG21 1 
ATOM   4465 H HG22 . VAL A 1 297 ? -15.63004 -23.00111 38.06984  1.000 40.94389 ? 297 VAL A HG22 1 
ATOM   4466 H HG23 . VAL A 1 297 ? -16.32185 -22.41535 36.76512  1.000 40.94389 ? 297 VAL A HG23 1 
ATOM   4467 N N    . ARG A 1 298 ? -13.39535 -25.91468 34.80761  1.000 42.01597 ? 298 ARG A N    1 
ATOM   4468 C CA   . ARG A 1 298 ? -12.55533 -27.07585 34.54119  1.000 40.60033 ? 298 ARG A CA   1 
ATOM   4469 C C    . ARG A 1 298 ? -11.09169 -26.71281 34.74793  1.000 36.98270 ? 298 ARG A C    1 
ATOM   4470 O O    . ARG A 1 298 ? -10.36142 -27.38069 35.49677  1.000 43.62079 ? 298 ARG A O    1 
ATOM   4471 C CB   . ARG A 1 298 ? -12.75642 -27.57912 33.09981  1.000 39.61760 ? 298 ARG A CB   1 
ATOM   4472 C CG   . ARG A 1 298 ? -14.10379 -28.21898 32.75994  1.000 41.53382 ? 298 ARG A CG   1 
ATOM   4473 C CD   . ARG A 1 298 ? -14.11070 -28.98015 31.40146  1.000 44.16830 ? 298 ARG A CD   1 
ATOM   4474 N NE   . ARG A 1 298 ? -14.04094 -28.14636 30.20700  1.000 39.62065 ? 298 ARG A NE   1 
ATOM   4475 C CZ   . ARG A 1 298 ? -12.98871 -28.08402 29.39541  1.000 44.77469 ? 298 ARG A CZ   1 
ATOM   4476 N NH1  . ARG A 1 298 ? -11.83635 -28.66930 29.71246  1.000 47.53777 ? 298 ARG A NH1  1 
ATOM   4477 N NH2  . ARG A 1 298 ? -13.09283 -27.41839 28.23678  1.000 40.77732 ? 298 ARG A NH2  1 
ATOM   4478 H H    . ARG A 1 298 ? -13.95328 -25.72274 34.18153  1.000 50.41917 ? 298 ARG A H    1 
ATOM   4479 H HA   . ARG A 1 298 ? -12.81197 -27.78942 35.14566  1.000 48.72040 ? 298 ARG A HA   1 
ATOM   4480 H HB2  . ARG A 1 298 ? -12.64681 -26.82266 32.50231  1.000 47.54112 ? 298 ARG A HB2  1 
ATOM   4481 H HB3  . ARG A 1 298 ? -12.07582 -28.24647 32.91963  1.000 47.54112 ? 298 ARG A HB3  1 
ATOM   4482 H HG2  . ARG A 1 298 ? -14.33353 -28.85459 33.45546  1.000 49.84059 ? 298 ARG A HG2  1 
ATOM   4483 H HG3  . ARG A 1 298 ? -14.77733 -27.52249 32.71213  1.000 49.84059 ? 298 ARG A HG3  1 
ATOM   4484 H HD2  . ARG A 1 298 ? -13.34522 -29.57453 31.38137  1.000 53.00195 ? 298 ARG A HD2  1 
ATOM   4485 H HD3  . ARG A 1 298 ? -14.93127 -29.49377 31.34386  1.000 53.00195 ? 298 ARG A HD3  1 
ATOM   4486 H HE   . ARG A 1 298 ? -14.72526 -27.66178 30.01406  1.000 47.54478 ? 298 ARG A HE   1 
ATOM   4487 H HH11 . ARG A 1 298 ? -11.76027 -29.09770 30.45522  1.000 57.04533 ? 298 ARG A HH11 1 
ATOM   4488 H HH12 . ARG A 1 298 ? -11.16620 -28.61843 29.17573  1.000 57.04533 ? 298 ARG A HH12 1 
ATOM   4489 H HH21 . ARG A 1 298 ? -13.83305 -27.03785 28.02376  1.000 48.93279 ? 298 ARG A HH21 1 
ATOM   4490 H HH22 . ARG A 1 298 ? -12.41767 -27.37352 27.70505  1.000 48.93279 ? 298 ARG A HH22 1 
ATOM   4491 N N    . GLN A 1 299 ? -10.64631 -25.64005 34.08875  1.000 28.94559 ? 299 GLN A N    1 
ATOM   4492 C CA   . GLN A 1 299 ? -9.23158  -25.30593 34.10345  1.000 36.01049 ? 299 GLN A CA   1 
ATOM   4493 C C    . GLN A 1 299 ? -8.79242  -24.87143 35.49187  1.000 44.21044 ? 299 GLN A C    1 
ATOM   4494 O O    . GLN A 1 299 ? -7.63737  -25.09875 35.87214  1.000 50.20256 ? 299 GLN A O    1 
ATOM   4495 C CB   . GLN A 1 299 ? -8.90408  -24.22103 33.06124  1.000 38.20302 ? 299 GLN A CB   1 
ATOM   4496 C CG   . GLN A 1 299 ? -7.38616  -24.02770 32.87189  1.000 37.41733 ? 299 GLN A CG   1 
ATOM   4497 C CD   . GLN A 1 299 ? -7.01528  -23.30861 31.58346  1.000 31.97386 ? 299 GLN A CD   1 
ATOM   4498 O OE1  . GLN A 1 299 ? -5.91967  -22.75866 31.45719  1.000 27.61163 ? 299 GLN A OE1  1 
ATOM   4499 N NE2  . GLN A 1 299 ? -7.87483  -23.42367 30.56509  1.000 31.84815 ? 299 GLN A NE2  1 
ATOM   4500 H H    . GLN A 1 299 ? -11.13858 -25.10016 33.63491  1.000 34.73470 ? 299 GLN A H    1 
ATOM   4501 H HA   . GLN A 1 299 ? -8.72386  -26.09337 33.85015  1.000 43.21258 ? 299 GLN A HA   1 
ATOM   4502 H HB2  . GLN A 1 299 ? -9.28457  -24.47580 32.20694  1.000 45.84362 ? 299 GLN A HB2  1 
ATOM   4503 H HB3  . GLN A 1 299 ? -9.28085  -23.37651 33.35462  1.000 45.84362 ? 299 GLN A HB3  1 
ATOM   4504 H HG2  . GLN A 1 299 ? -7.04384  -23.50388 33.61233  1.000 44.90080 ? 299 GLN A HG2  1 
ATOM   4505 H HG3  . GLN A 1 299 ? -6.96046  -24.89935 32.85650  1.000 44.90080 ? 299 GLN A HG3  1 
ATOM   4506 H HE21 . GLN A 1 299 ? -8.59349  -23.88730 30.65955  1.000 38.21778 ? 299 GLN A HE21 1 
ATOM   4507 H HE22 . GLN A 1 299 ? -7.70887  -23.03607 29.81639  1.000 38.21778 ? 299 GLN A HE22 1 
ATOM   4508 N N    . CYS A 1 300 ? -9.68218  -24.26362 36.27194  1.000 41.59441 ? 300 CYS A N    1 
ATOM   4509 C CA   . CYS A 1 300 ? -9.27702  -23.78911 37.59237  1.000 46.94981 ? 300 CYS A CA   1 
ATOM   4510 C C    . CYS A 1 300 ? -9.29352  -24.89178 38.65669  1.000 47.10870 ? 300 CYS A C    1 
ATOM   4511 O O    . CYS A 1 300 ? -8.55696  -24.77680 39.63902  1.000 47.49771 ? 300 CYS A O    1 
ATOM   4512 C CB   . CYS A 1 300 ? -10.15311 -22.58204 37.96181  1.000 41.42224 ? 300 CYS A CB   1 
ATOM   4513 S SG   . CYS A 1 300 ? -9.71890  -21.11703 36.88586  1.000 41.09368 ? 300 CYS A SG   1 
ATOM   4514 H H    . CYS A 1 300 ? -10.50422 -24.11815 36.06574  1.000 49.91330 ? 300 CYS A H    1 
ATOM   4515 H HA   . CYS A 1 300 ? -8.35927  -23.47538 37.58189  1.000 56.33978 ? 300 CYS A HA   1 
ATOM   4516 H HB2  . CYS A 1 300 ? -11.08789 -22.80370 37.82334  1.000 49.70669 ? 300 CYS A HB2  1 
ATOM   4517 H HB3  . CYS A 1 300 ? -10.00263 -22.34249 38.88901  1.000 49.70669 ? 300 CYS A HB3  1 
ATOM   4518 H HG   . CYS A 1 300 ? -9.64521  -21.47827 35.74467  1.000 49.31241 ? 300 CYS A HG   1 
ATOM   4519 N N    . SER A 1 301 ? -10.02957 -25.99224 38.44575  1.000 47.85388 ? 301 SER A N    1 
ATOM   4520 C CA   . SER A 1 301 ? -10.09904 -27.08489 39.41305  1.000 42.24345 ? 301 SER A CA   1 
ATOM   4521 C C    . SER A 1 301 ? -9.51081  -28.40612 38.91244  1.000 52.59373 ? 301 SER A C    1 
ATOM   4522 O O    . SER A 1 301 ? -9.70421  -29.44967 39.56173  1.000 45.84259 ? 301 SER A O    1 
ATOM   4523 C CB   . SER A 1 301 ? -11.55705 -27.27132 39.85242  1.000 51.59978 ? 301 SER A CB   1 
ATOM   4524 O OG   . SER A 1 301 ? -12.29104 -28.16740 39.02661  1.000 51.75518 ? 301 SER A OG   1 
ATOM   4525 H H    . SER A 1 301 ? -10.50221 -26.12618 37.73950  1.000 57.42466 ? 301 SER A H    1 
ATOM   4526 H HA   . SER A 1 301 ? -9.56551  -26.84294 40.18639  1.000 50.69215 ? 301 SER A HA   1 
ATOM   4527 H HB2  . SER A 1 301 ? -11.56009 -27.61988 40.75720  1.000 61.91974 ? 301 SER A HB2  1 
ATOM   4528 H HB3  . SER A 1 301 ? -11.99573 -26.40666 39.82780  1.000 61.91974 ? 301 SER A HB3  1 
ATOM   4529 H HG   . SER A 1 301 ? -11.92844 -28.92512 39.03227  1.000 62.10622 ? 301 SER A HG   1 
ATOM   4530 N N    . GLY A 1 302 ? -8.77843  -28.38785 37.80071  1.000 50.77459 ? 302 GLY A N    1 
ATOM   4531 C CA   . GLY A 1 302 ? -8.08633  -29.56200 37.31123  1.000 40.69903 ? 302 GLY A CA   1 
ATOM   4532 C C    . GLY A 1 302 ? -8.97126  -30.73348 36.94720  1.000 50.48988 ? 302 GLY A C    1 
ATOM   4533 O O    . GLY A 1 302 ? -8.66550  -31.85947 37.33261  1.000 42.02573 ? 302 GLY A O    1 
ATOM   4534 H H    . GLY A 1 302 ? -8.66881  -27.69246 37.30818  1.000 60.92951 ? 302 GLY A H    1 
ATOM   4535 H HA2  . GLY A 1 302 ? -7.58524  -29.31711 36.51756  1.000 48.83884 ? 302 GLY A HA2  1 
ATOM   4536 H HA3  . GLY A 1 302 ? -7.46733  -29.86392 37.99426  1.000 48.83884 ? 302 GLY A HA3  1 
HETATM 4537 O O    . HOH B 2 .   ? -17.23700 -2.73600  41.06500  1.000 41.18473 ? 401 HOH A O    1 
HETATM 4538 O O    . HOH B 2 .   ? -20.83500 -54.14800 10.43200  1.000 38.30771 ? 402 HOH A O    1 
HETATM 4539 O O    . HOH B 2 .   ? -25.22200 -17.26100 10.16000  1.000 24.96102 ? 403 HOH A O    1 
HETATM 4540 O O    . HOH B 2 .   ? -14.01500 -17.80200 18.17900  1.000 24.42132 ? 404 HOH A O    1 
HETATM 4541 O O    . HOH B 2 .   ? -12.14000 -49.79500 1.44000   1.000 30.56695 ? 405 HOH A O    1 
HETATM 4542 O O    . HOH B 2 .   ? -12.39200 -23.12100 25.78000  1.000 26.01519 ? 406 HOH A O    1 
HETATM 4543 O O    . HOH B 2 .   ? -6.85800  -46.43500 14.68200  1.000 40.41348 ? 407 HOH A O    1 
HETATM 4544 O O    . HOH B 2 .   ? -10.08300 -44.51900 20.16000  1.000 33.04010 ? 408 HOH A O    1 
HETATM 4545 O O    . HOH B 2 .   ? -28.19100 -34.33300 -11.75500 1.000 39.18990 ? 409 HOH A O    1 
HETATM 4546 O O    . HOH B 2 .   ? -15.36800 -4.27600  39.34200  1.000 42.34930 ? 410 HOH A O    1 
HETATM 4547 O O    . HOH B 2 .   ? -23.39300 -0.00500  17.86100  1.000 42.51302 ? 411 HOH A O    1 
HETATM 4548 O O    . HOH B 2 .   ? -18.50000 -8.08200  18.85300  1.000 32.04121 ? 412 HOH A O    1 
HETATM 4549 O O    . HOH B 2 .   ? -7.57000  -3.87600  22.40900  1.000 36.65121 ? 413 HOH A O    1 
HETATM 4550 O O    . HOH B 2 .   ? -17.45500 -4.45600  20.15500  1.000 32.31855 ? 414 HOH A O    1 
HETATM 4551 O O    . HOH B 2 .   ? -33.611   -7.608    30.590    1.000 45.91223 ? 415 HOH A O    1 
HETATM 4552 O O    . HOH B 2 .   ? -21.30600 -39.61000 -9.00800  1.000 36.49592 ? 416 HOH A O    1 
HETATM 4553 O O    . HOH B 2 .   ? -14.71200 -1.23500  23.04400  1.000 33.40652 ? 417 HOH A O    1 
HETATM 4554 O O    . HOH B 2 .   ? -10.51200 -28.22100 26.63900  1.000 32.55303 ? 418 HOH A O    1 
HETATM 4555 O O    . HOH B 2 .   ? -9.11700  -44.03500 1.07200   1.000 38.11926 ? 419 HOH A O    1 
HETATM 4556 O O    . HOH B 2 .   ? -24.08400 -20.93600 24.33000  1.000 31.70903 ? 420 HOH A O    1 
HETATM 4557 O O    . HOH B 2 .   ? -14.78200 -27.27700 25.37400  1.000 30.11948 ? 421 HOH A O    1 
HETATM 4558 O O    . HOH B 2 .   ? -12.92500 -2.14900  34.09200  1.000 33.69392 ? 422 HOH A O    1 
HETATM 4559 O O    . HOH B 2 .   ? -21.08700 -19.86200 26.35900  1.000 24.25684 ? 423 HOH A O    1 
HETATM 4560 O O    . HOH B 2 .   ? -31.94000 -34.33700 -5.47700  1.000 38.53988 ? 424 HOH A O    1 
HETATM 4561 O O    . HOH B 2 .   ? -10.69100 -35.03600 13.51500  1.000 21.29800 ? 425 HOH A O    1 
HETATM 4562 O O    . HOH B 2 .   ? -32.61500 -17.00700 28.69300  1.000 38.96416 ? 426 HOH A O    1 
HETATM 4563 O O    . HOH B 2 .   ? -17.10600 -13.75400 13.30500  1.000 38.08948 ? 427 HOH A O    1 
HETATM 4564 O O    . HOH B 2 .   ? -6.97700  -12.92200 42.87900  1.000 39.19995 ? 428 HOH A O    1 
HETATM 4565 O O    . HOH B 2 .   ? -1.19500  2.06400   29.85300  1.000 32.92695 ? 429 HOH A O    1 
HETATM 4566 O O    . HOH B 2 .   ? -20.48600 -12.95900 44.48100  1.000 37.60194 ? 430 HOH A O    1 
HETATM 4567 O O    . HOH B 2 .   ? -7.50700  -46.65000 0.48000   1.000 54.34695 ? 431 HOH A O    1 
HETATM 4568 O O    . HOH B 2 .   ? -19.37800 -7.90300  44.47100  1.000 35.83992 ? 432 HOH A O    1 
HETATM 4569 O O    . HOH B 2 .   ? -29.01400 -13.19600 24.79300  1.000 30.76309 ? 433 HOH A O    1 
HETATM 4570 O O    . HOH B 2 .   ? -26.07100 -20.25600 2.70800   1.000 29.16007 ? 434 HOH A O    1 
HETATM 4571 O O    . HOH B 2 .   ? -21.62400 -45.41900 14.68200  1.000 31.50741 ? 435 HOH A O    1 
HETATM 4572 O O    . HOH B 2 .   ? -14.36700 -19.98900 16.36200  1.000 17.57028 ? 436 HOH A O    1 
HETATM 4573 O O    . HOH B 2 .   ? -19.23100 -37.49600 -8.86300  1.000 38.91967 ? 437 HOH A O    1 
HETATM 4574 O O    . HOH B 2 .   ? -25.31900 -39.89800 11.84700  1.000 29.51315 ? 438 HOH A O    1 
HETATM 4575 O O    . HOH B 2 .   ? -20.03100 -52.48300 -4.61500  1.000 35.90579 ? 439 HOH A O    1 
HETATM 4576 O O    . HOH B 2 .   ? -33.57200 -11.66500 36.32900  1.000 31.92788 ? 440 HOH A O    1 
HETATM 4577 O O    . HOH B 2 .   ? -29.36300 -35.70900 2.19700   1.000 30.29132 ? 441 HOH A O    1 
HETATM 4578 O O    . HOH B 2 .   ? -15.76100 -51.43300 19.07700  1.000 31.83648 ? 442 HOH A O    1 
HETATM 4579 O O    . HOH B 2 .   ? -31.69800 -9.37400  29.33000  1.000 36.06089 ? 443 HOH A O    1 
HETATM 4580 O O    . HOH B 2 .   ? -21.67800 -22.88600 35.65500  1.000 32.90608 ? 444 HOH A O    1 
HETATM 4581 O O    . HOH B 2 .   ? -29.15700 -27.26600 9.35600   1.000 35.50225 ? 445 HOH A O    1 
HETATM 4582 O O    . HOH B 2 .   ? -28.23700 -24.69800 6.59400   1.000 24.41845 ? 446 HOH A O    1 
HETATM 4583 O O    . HOH B 2 .   ? -13.97000 -16.23300 27.21300  1.000 19.69149 ? 447 HOH A O    1 
HETATM 4584 O O    . HOH B 2 .   ? -14.52500 -6.47500  22.72100  1.000 26.48115 ? 448 HOH A O    1 
HETATM 4585 O O    . HOH B 2 .   ? -25.60400 -4.35200  41.48000  1.000 36.10220 ? 449 HOH A O    1 
HETATM 4586 O O    . HOH B 2 .   ? -21.32100 -24.17500 10.26000  1.000 20.78983 ? 450 HOH A O    1 
HETATM 4587 O O    . HOH B 2 .   ? -27.04100 -6.98500  22.30900  1.000 37.76941 ? 451 HOH A O    1 
HETATM 4588 O O    . HOH B 2 .   ? -6.45100  -14.88800 27.73600  1.000 27.75778 ? 452 HOH A O    1 
HETATM 4589 O O    . HOH B 2 .   ? -12.71200 -2.53100  24.66500  1.000 34.03955 ? 453 HOH A O    1 
HETATM 4590 O O    . HOH B 2 .   ? -27.20300 -25.14800 17.46100  1.000 32.51530 ? 454 HOH A O    1 
HETATM 4591 O O    . HOH B 2 .   ? -21.92800 1.47800   35.69000  1.000 37.13691 ? 455 HOH A O    1 
HETATM 4592 O O    . HOH B 2 .   ? -27.66100 -3.50300  40.10900  1.000 34.07138 ? 456 HOH A O    1 
HETATM 4593 O O    . HOH B 2 .   ? -23.26800 4.06700   30.29700  1.000 46.55907 ? 457 HOH A O    1 
HETATM 4594 O O    . HOH B 2 .   ? -17.92700 -15.37500 10.92000  1.000 38.06442 ? 458 HOH A O    1 
HETATM 4595 O O    . HOH B 2 .   ? -27.60400 -27.26800 4.46000   1.000 26.20576 ? 459 HOH A O    1 
HETATM 4596 O O    . HOH B 2 .   ? -20.66100 -32.27700 2.21600   1.000 17.59963 ? 460 HOH A O    1 
HETATM 4597 O O    . HOH B 2 .   ? -26.46000 -17.77700 4.06400   1.000 28.92163 ? 461 HOH A O    1 
HETATM 4598 O O    . HOH B 2 .   ? -26.32900 -19.42100 39.98900  1.000 27.87391 ? 462 HOH A O    1 
HETATM 4599 O O    . HOH B 2 .   ? -19.29500 0.76600   34.55800  1.000 37.40041 ? 463 HOH A O    1 
HETATM 4600 O O    . HOH B 2 .   ? -28.46700 -32.15800 -3.89500  1.000 34.46697 ? 464 HOH A O    1 
HETATM 4601 O O    . HOH B 2 .   ? -26.48800 -28.42200 2.05900   1.000 21.28092 ? 465 HOH A O    1 
HETATM 4602 O O    . HOH B 2 .   ? -26.14600 -17.88500 -1.32500  1.000 40.56036 ? 466 HOH A O    1 
HETATM 4603 O O    . HOH B 2 .   ? -10.53200 -24.66800 29.93600  1.000 32.22206 ? 467 HOH A O    1 
HETATM 4604 O O    . HOH B 2 .   ? -15.55600 -16.75400 48.17900  1.000 34.40166 ? 468 HOH A O    1 
HETATM 4605 O O    . HOH B 2 .   ? -28.99800 -40.25700 13.46400  1.000 38.28330 ? 469 HOH A O    1 
HETATM 4606 O O    . HOH B 2 .   ? -31.73400 -37.77700 10.42300  1.000 36.60259 ? 470 HOH A O    1 
HETATM 4607 O O    . HOH B 2 .   ? -25.85200 -5.15900  18.48800  1.000 40.74966 ? 471 HOH A O    1 
HETATM 4608 O O    . HOH B 2 .   ? -3.399    -21.546   40.680    1.000 45.43219 ? 472 HOH A O    1 
HETATM 4609 O O    . HOH B 2 .   ? -26.61400 -17.18300 18.10700  1.000 38.97880 ? 473 HOH A O    1 
HETATM 4610 O O    . HOH B 2 .   ? -28.56700 -42.71600 0.83400   1.000 32.11031 ? 474 HOH A O    1 
HETATM 4611 O O    . HOH B 2 .   ? -8.58400  -38.57100 24.49100  1.000 26.85082 ? 475 HOH A O    1 
HETATM 4612 O O    . HOH B 2 .   ? -26.13400 -45.10100 -4.54300  1.000 28.12627 ? 476 HOH A O    1 
HETATM 4613 O O    . HOH B 2 .   ? -1.62000  -9.81200  31.04500  1.000 38.27516 ? 477 HOH A O    1 
HETATM 4614 O O    . HOH B 2 .   ? -30.47400 -38.16800 2.33500   1.000 33.63077 ? 478 HOH A O    1 
HETATM 4615 O O    . HOH B 2 .   ? -11.57800 -31.38100 40.45900  1.000 49.29949 ? 479 HOH A O    1 
HETATM 4616 O O    . HOH B 2 .   ? -29.30700 2.75000   32.15300  1.000 43.85703 ? 480 HOH A O    1 
HETATM 4617 O O    . HOH B 2 .   ? -19.75000 -0.25400  17.97500  1.000 40.56467 ? 481 HOH A O    1 
HETATM 4618 O O    . HOH B 2 .   ? -24.98500 -13.10900 15.78600  1.000 37.93598 ? 482 HOH A O    1 
HETATM 4619 O O    . HOH B 2 .   ? -23.59200 -34.29500 16.35000  1.000 22.83646 ? 483 HOH A O    1 
HETATM 4620 O O    . HOH B 2 .   ? -13.02100 -51.11900 -3.54100  1.000 39.16526 ? 484 HOH A O    1 
HETATM 4621 O O    . HOH B 2 .   ? -21.60900 -54.75200 -1.08300  1.000 33.91949 ? 485 HOH A O    1 
HETATM 4622 O O    . HOH B 2 .   ? -18.91800 -26.19800 25.56100  1.000 31.94226 ? 486 HOH A O    1 
HETATM 4623 O O    . HOH B 2 .   ? -23.52600 -50.67400 -3.57300  1.000 30.71503 ? 487 HOH A O    1 
HETATM 4624 O O    . HOH B 2 .   ? -23.76900 -14.20100 26.36300  1.000 23.92267 ? 488 HOH A O    1 
HETATM 4625 O O    . HOH B 2 .   ? 0.413     -29.388   15.165    1.000 30.86472 ? 489 HOH A O    1 
HETATM 4626 O O    . HOH B 2 .   ? -16.38300 -22.73300 -0.68600  1.000 41.65772 ? 490 HOH A O    1 
HETATM 4627 O O    . HOH B 2 .   ? -1.67500  -17.26700 32.37600  1.000 33.90251 ? 491 HOH A O    1 
HETATM 4628 O O    . HOH B 2 .   ? -22.03700 -21.79700 -7.90500  1.000 40.05124 ? 492 HOH A O    1 
HETATM 4629 O O    . HOH B 2 .   ? -22.78600 -34.46700 26.14700  1.000 38.61613 ? 493 HOH A O    1 
HETATM 4630 O O    . HOH B 2 .   ? -15.49000 3.17000   22.10600  1.000 41.91288 ? 494 HOH A O    1 
HETATM 4631 O O    . HOH B 2 .   ? -32.64400 -16.19700 31.03200  1.000 37.23467 ? 495 HOH A O    1 
HETATM 4632 O O    . HOH B 2 .   ? -19.53600 -31.63400 22.20800  1.000 26.17253 ? 496 HOH A O    1 
HETATM 4633 O O    . HOH B 2 .   ? -28.74100 -40.99700 -3.78600  1.000 27.16051 ? 497 HOH A O    1 
HETATM 4634 O O    . HOH B 2 .   ? -7.033    -22.321   19.632    1.000 37.80844 ? 498 HOH A O    1 
HETATM 4635 O O    . HOH B 2 .   ? -13.79300 -13.07800 19.44500  1.000 35.86539 ? 499 HOH A O    1 
HETATM 4636 O O    . HOH B 2 .   ? -25.90600 -16.28800 39.72000  1.000 31.36406 ? 500 HOH A O    1 
HETATM 4637 O O    . HOH B 2 .   ? -22.30900 -42.60500 25.37000  1.000 41.77540 ? 501 HOH A O    1 
HETATM 4638 O O    . HOH B 2 .   ? -24.71400 -32.69600 -9.96600  1.000 24.91105 ? 502 HOH A O    1 
HETATM 4639 O O    . HOH B 2 .   ? -28.06200 -29.12500 6.59600   1.000 24.68903 ? 503 HOH A O    1 
HETATM 4640 O O    . HOH B 2 .   ? -24.11900 -26.71700 23.63800  1.000 36.72529 ? 504 HOH A O    1 
HETATM 4641 O O    . HOH B 2 .   ? -25.30200 -9.60000  40.28500  1.000 31.09017 ? 505 HOH A O    1 
HETATM 4642 O O    . HOH B 2 .   ? -6.32400  -43.34300 9.31500   1.000 37.35544 ? 506 HOH A O    1 
HETATM 4643 O O    . HOH B 2 .   ? -7.88800  -1.18600  23.95000  1.000 40.56272 ? 507 HOH A O    1 
HETATM 4644 O O    . HOH B 2 .   ? -9.85500  -23.96300 27.14200  1.000 33.94134 ? 508 HOH A O    1 
HETATM 4645 O O    . HOH B 2 .   ? -20.59500 -23.10100 30.51600  1.000 32.80662 ? 509 HOH A O    1 
HETATM 4646 O O    . HOH B 2 .   ? -19.00500 -16.13700 1.38700   1.000 34.65041 ? 510 HOH A O    1 
HETATM 4647 O O    . HOH B 2 .   ? -23.00800 -1.59100  15.86800  1.000 43.76253 ? 511 HOH A O    1 
HETATM 4648 O O    . HOH B 2 .   ? -13.66700 1.80900   23.25000  1.000 37.87385 ? 512 HOH A O    1 
HETATM 4649 O O    . HOH B 2 .   ? -22.12700 -21.60700 28.64100  1.000 33.94017 ? 513 HOH A O    1 
HETATM 4650 O O    . HOH B 2 .   ? -28.29300 -6.42800  24.58800  1.000 39.13120 ? 514 HOH A O    1 
HETATM 4651 O O    . HOH B 2 .   ? -11.86800 -6.53000  22.62200  1.000 26.75511 ? 515 HOH A O    1 
HETATM 4652 O O    . HOH B 2 .   ? -30.33200 -5.56300  37.28900  1.000 39.28805 ? 516 HOH A O    1 
HETATM 4653 O O    . HOH B 2 .   ? -8.87500  0.86800   30.65400  1.000 41.66285 ? 517 HOH A O    1 
HETATM 4654 O O    . HOH B 2 .   ? -28.43100 -23.84200 12.85500  1.000 38.40468 ? 518 HOH A O    1 
HETATM 4655 O O    . HOH B 2 .   ? -28.93900 -25.01200 15.49500  1.000 41.19703 ? 519 HOH A O    1 
HETATM 4656 O O    . HOH B 2 .   ? -18.07000 -25.97300 27.80900  1.000 30.64347 ? 520 HOH A O    1 
HETATM 4657 O O    . HOH B 2 .   ? -31.88000 -35.15000 10.85000  1.000 40.31604 ? 521 HOH A O    1 
HETATM 4658 O O    . HOH B 2 .   ? -3.48900  -20.16800 24.89000  1.000 40.46675 ? 522 HOH A O    1 
HETATM 4659 O O    . HOH B 2 .   ? -31.49600 -37.23300 4.84700   1.000 29.00698 ? 523 HOH A O    1 
HETATM 4660 O O    . HOH B 2 .   ? -11.97400 -14.27800 21.14800  1.000 37.49225 ? 524 HOH A O    1 
HETATM 4661 O O    . HOH B 2 .   ? -8.08000  -21.48900 1.82200   1.000 42.82401 ? 525 HOH A O    1 
HETATM 4662 O O    . HOH B 2 .   ? -18.45900 -15.07400 47.78800  1.000 37.06975 ? 526 HOH A O    1 
HETATM 4663 O O    . HOH B 2 .   ? -12.94300 -23.73800 40.04700  1.000 44.36057 ? 527 HOH A O    1 
HETATM 4664 O O    . HOH B 2 .   ? -29.26300 -10.25000 37.07200  1.000 34.06506 ? 528 HOH A O    1 
HETATM 4665 O O    . HOH B 2 .   ? -14.02500 -25.41900 0.94400   1.000 30.29377 ? 529 HOH A O    1 
HETATM 4666 O O    . HOH B 2 .   ? -6.78500  -15.21700 43.68800  1.000 37.17154 ? 530 HOH A O    1 
HETATM 4667 O O    . HOH B 2 .   ? -14.69200 -28.00100 0.74900   1.000 29.49229 ? 531 HOH A O    1 
HETATM 4668 O O    . HOH B 2 .   ? -27.77300 -46.93500 -1.05900  1.000 46.84600 ? 532 HOH A O    1 
HETATM 4669 O O    . HOH B 2 .   ? -28.85800 -12.79000 39.97600  1.000 24.69411 ? 533 HOH A O    1 
HETATM 4670 O O    . HOH B 2 .   ? -21.16900 -35.51500 -12.44200 1.000 49.82370 ? 534 HOH A O    1 
HETATM 4671 O O    . HOH B 2 .   ? -19.379   -46.924   21.813    1.000 41.29670 ? 535 HOH A O    1 
HETATM 4672 O O    . HOH B 2 .   ? -12.81100 -2.88900  43.05400  1.000 47.11388 ? 536 HOH A O    1 
HETATM 4673 O O    . HOH B 2 .   ? -32.10100 -4.46800  35.20300  1.000 37.36788 ? 537 HOH A O    1 
HETATM 4674 O O    . HOH B 2 .   ? -29.47500 -16.03900 25.36100  1.000 38.16506 ? 538 HOH A O    1 
HETATM 4675 O O    . HOH B 2 .   ? -12.45900 -19.66500 46.83900  1.000 40.98526 ? 539 HOH A O    1 
HETATM 4676 O O    . HOH B 2 .   ? -23.33300 -44.77400 21.10800  1.000 46.18672 ? 540 HOH A O    1 
HETATM 4677 O O    . HOH B 2 .   ? -27.71300 -44.52200 -0.88800  1.000 26.98495 ? 541 HOH A O    1 
HETATM 4678 O O    . HOH B 2 .   ? -7.924    -23.924   -3.131    1.000 41.64714 ? 542 HOH A O    1 
HETATM 4679 O O    . HOH B 2 .   ? -20.67700 -28.02900 25.31100  1.000 40.82309 ? 543 HOH A O    1 
HETATM 4680 O O    . HOH B 2 .   ? -12.670   -54.257   -0.092    1.000 40.92330 ? 544 HOH A O    1 
HETATM 4681 O O    . HOH B 2 .   ? -31.41000 -12.90700 40.80600  1.000 40.98856 ? 545 HOH A O    1 
HETATM 4682 O O    . HOH B 2 .   ? -26.47100 -41.34400 13.50100  1.000 38.36534 ? 546 HOH A O    1 
HETATM 4683 O O    . HOH B 2 .   ? -12.39800 -29.22600 -12.26400 1.000 53.90687 ? 547 HOH A O    1 
HETATM 4684 O O    . HOH B 2 .   ? -24.89800 -42.88100 18.39800  1.000 42.91294 ? 548 HOH A O    1 
HETATM 4685 O O    . HOH B 2 .   ? -13.32700 -14.13900 17.09700  1.000 38.16972 ? 549 HOH A O    1 
HETATM 4686 O O    . HOH B 2 .   ? -9.965    -25.487   -4.320    1.000 40.58183 ? 550 HOH A O    1 
HETATM 4687 O O    . HOH B 2 .   ? -28.15400 -43.82200 -3.70000  1.000 30.65364 ? 551 HOH A O    1 
HETATM 4688 O O    . HOH B 2 .   ? -23.54300 -18.87000 25.63100  1.000 33.52848 ? 552 HOH A O    1 
HETATM 4689 O O    . HOH B 2 .   ? -26.34900 -14.80800 19.87900  1.000 32.97437 ? 553 HOH A O    1 
HETATM 4690 O O    . HOH B 2 .   ? -15.33500 -53.79900 19.33700  1.000 42.13570 ? 554 HOH A O    1 
HETATM 4691 O O    . HOH B 2 .   ? -27.34400 -17.55100 11.98000  1.000 30.16479 ? 555 HOH A O    1 
HETATM 4692 O O    . HOH B 2 .   ? -19.140   -54.385   -2.684    1.000 35.00014 ? 556 HOH A O    1 
HETATM 4693 O O    . HOH B 2 .   ? -17.94000 -1.63600  18.48800  1.000 40.63589 ? 557 HOH A O    1 
HETATM 4694 O O    . HOH B 2 .   ? -30.80900 -6.27600  24.72700  1.000 42.74845 ? 558 HOH A O    1 
HETATM 4695 O O    . HOH B 2 .   ? -31.31900 -38.88000 -0.46300  1.000 35.61058 ? 559 HOH A O    1 
HETATM 4696 O O    . HOH B 2 .   ? -10.86900 -4.20600  23.11300  1.000 35.65608 ? 560 HOH A O    1 
HETATM 4697 O O    . HOH B 2 .   ? -30.78900 -8.30200  37.39600  1.000 31.85185 ? 561 HOH A O    1 
HETATM 4698 O O    . HOH B 2 .   ? -15.36900 -3.98300  22.02100  1.000 34.23388 ? 562 HOH A O    1 
HETATM 4699 O O    . HOH B 2 .   ? -27.370   -13.907   0.985     1.000 33.10473 ? 563 HOH A O    1 
HETATM 4700 O O    . HOH B 2 .   ? 0.46800   0.79200   31.10000  1.000 38.87178 ? 564 HOH A O    1 
HETATM 4701 O O    . HOH B 2 .   ? -18.62300 -14.07800 -0.20100  1.000 41.36494 ? 565 HOH A O    1 
HETATM 4702 O O    . HOH B 2 .   ? -26.33800 -14.19300 40.94700  1.000 32.90790 ? 566 HOH A O    1 
HETATM 4703 O O    . HOH B 2 .   ? -29.86100 -5.34000  40.09900  1.000 43.03166 ? 567 HOH A O    1 
HETATM 4704 O O    . HOH B 2 .   ? -27.60100 -10.25700 39.63000  1.000 31.45650 ? 568 HOH A O    1 
HETATM 4705 O O    . HOH B 2 .   ? -8.77105  -6.06700  43.87488  0.50  32.95319 ? 569 HOH A O    1 
HETATM 4706 O O    . HOH B 2 .   ? -23.49800 -29.38500 24.61400  1.000 40.69750 ? 570 HOH A O    1 
# 
