data_9BNU
# 
_entry.id   9BNU 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BNU         pdb_00009bnu 10.2210/pdb9bnu/pdb 
WWPDB D_1000283648 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-12 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BNU 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-03 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              karen.anderson@yale.edu 
_pdbx_contact_author.name_first         Karen 
_pdbx_contact_author.name_last          Anderson 
_pdbx_contact_author.name_mi            S 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3433-0780 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Papini, C.'     1 0000-0002-6098-4959 
'Anderson, K.S.' 2 0000-0003-3433-0780 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acs Bio Med Chem Au' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2694-2437 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Exploring Possible Drug-Resistant Variants of SARS-CoV-2 Main Protease (Mpro) with Noncovalent Preclinical Candidate, Mpro61' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acsbiomedchemau.4c00109 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kenneson, J.R.'  1 ? 
primary 'Papini, C.'      2 ? 
primary 'Tang, S.'        3 ? 
primary 'Huynh, K.'       4 ? 
primary 'Zhang, C.H.'     5 ? 
primary 'Jorgensen, W.L.' 6 ? 
primary 'Anderson, K.S.'  7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man '3C-like proteinase nsp5' 33837.602 1   3.4.22.69 ? ? ? 
2 water   nat water                     18.015    319 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQIAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQIAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   GLY n 
1 3   PHE n 
1 4   ARG n 
1 5   LYS n 
1 6   MET n 
1 7   ALA n 
1 8   PHE n 
1 9   PRO n 
1 10  SER n 
1 11  GLY n 
1 12  LYS n 
1 13  VAL n 
1 14  GLU n 
1 15  GLY n 
1 16  CYS n 
1 17  MET n 
1 18  VAL n 
1 19  GLN n 
1 20  VAL n 
1 21  THR n 
1 22  CYS n 
1 23  GLY n 
1 24  THR n 
1 25  THR n 
1 26  THR n 
1 27  LEU n 
1 28  ASN n 
1 29  GLY n 
1 30  LEU n 
1 31  TRP n 
1 32  LEU n 
1 33  ASP n 
1 34  ASP n 
1 35  VAL n 
1 36  VAL n 
1 37  TYR n 
1 38  CYS n 
1 39  PRO n 
1 40  ARG n 
1 41  HIS n 
1 42  VAL n 
1 43  ILE n 
1 44  CYS n 
1 45  THR n 
1 46  SER n 
1 47  GLU n 
1 48  ASP n 
1 49  MET n 
1 50  LEU n 
1 51  ASN n 
1 52  PRO n 
1 53  ASN n 
1 54  TYR n 
1 55  GLU n 
1 56  ASP n 
1 57  LEU n 
1 58  LEU n 
1 59  ILE n 
1 60  ARG n 
1 61  LYS n 
1 62  SER n 
1 63  ASN n 
1 64  HIS n 
1 65  ASN n 
1 66  PHE n 
1 67  LEU n 
1 68  VAL n 
1 69  GLN n 
1 70  ALA n 
1 71  GLY n 
1 72  ASN n 
1 73  VAL n 
1 74  GLN n 
1 75  LEU n 
1 76  ARG n 
1 77  VAL n 
1 78  ILE n 
1 79  GLY n 
1 80  HIS n 
1 81  SER n 
1 82  MET n 
1 83  GLN n 
1 84  ASN n 
1 85  CYS n 
1 86  VAL n 
1 87  LEU n 
1 88  LYS n 
1 89  LEU n 
1 90  LYS n 
1 91  VAL n 
1 92  ASP n 
1 93  THR n 
1 94  ALA n 
1 95  ASN n 
1 96  PRO n 
1 97  LYS n 
1 98  THR n 
1 99  PRO n 
1 100 LYS n 
1 101 TYR n 
1 102 LYS n 
1 103 PHE n 
1 104 VAL n 
1 105 ARG n 
1 106 ILE n 
1 107 GLN n 
1 108 PRO n 
1 109 GLY n 
1 110 GLN n 
1 111 THR n 
1 112 PHE n 
1 113 SER n 
1 114 VAL n 
1 115 LEU n 
1 116 ALA n 
1 117 CYS n 
1 118 TYR n 
1 119 ASN n 
1 120 GLY n 
1 121 SER n 
1 122 PRO n 
1 123 SER n 
1 124 GLY n 
1 125 VAL n 
1 126 TYR n 
1 127 GLN n 
1 128 CYS n 
1 129 ALA n 
1 130 MET n 
1 131 ARG n 
1 132 PRO n 
1 133 ASN n 
1 134 PHE n 
1 135 THR n 
1 136 ILE n 
1 137 LYS n 
1 138 GLY n 
1 139 SER n 
1 140 PHE n 
1 141 LEU n 
1 142 ASN n 
1 143 GLY n 
1 144 SER n 
1 145 CYS n 
1 146 GLY n 
1 147 SER n 
1 148 VAL n 
1 149 GLY n 
1 150 PHE n 
1 151 ASN n 
1 152 ILE n 
1 153 ASP n 
1 154 TYR n 
1 155 ASP n 
1 156 CYS n 
1 157 VAL n 
1 158 SER n 
1 159 PHE n 
1 160 CYS n 
1 161 TYR n 
1 162 MET n 
1 163 HIS n 
1 164 HIS n 
1 165 MET n 
1 166 GLU n 
1 167 LEU n 
1 168 PRO n 
1 169 THR n 
1 170 GLY n 
1 171 VAL n 
1 172 HIS n 
1 173 ALA n 
1 174 GLY n 
1 175 THR n 
1 176 ASP n 
1 177 LEU n 
1 178 GLU n 
1 179 GLY n 
1 180 ASN n 
1 181 PHE n 
1 182 TYR n 
1 183 GLY n 
1 184 PRO n 
1 185 PHE n 
1 186 VAL n 
1 187 ASP n 
1 188 ARG n 
1 189 GLN n 
1 190 ILE n 
1 191 ALA n 
1 192 GLN n 
1 193 ALA n 
1 194 ALA n 
1 195 GLY n 
1 196 THR n 
1 197 ASP n 
1 198 THR n 
1 199 THR n 
1 200 ILE n 
1 201 THR n 
1 202 VAL n 
1 203 ASN n 
1 204 VAL n 
1 205 LEU n 
1 206 ALA n 
1 207 TRP n 
1 208 LEU n 
1 209 TYR n 
1 210 ALA n 
1 211 ALA n 
1 212 VAL n 
1 213 ILE n 
1 214 ASN n 
1 215 GLY n 
1 216 ASP n 
1 217 ARG n 
1 218 TRP n 
1 219 PHE n 
1 220 LEU n 
1 221 ASN n 
1 222 ARG n 
1 223 PHE n 
1 224 THR n 
1 225 THR n 
1 226 THR n 
1 227 LEU n 
1 228 ASN n 
1 229 ASP n 
1 230 PHE n 
1 231 ASN n 
1 232 LEU n 
1 233 VAL n 
1 234 ALA n 
1 235 MET n 
1 236 LYS n 
1 237 TYR n 
1 238 ASN n 
1 239 TYR n 
1 240 GLU n 
1 241 PRO n 
1 242 LEU n 
1 243 THR n 
1 244 GLN n 
1 245 ASP n 
1 246 HIS n 
1 247 VAL n 
1 248 ASP n 
1 249 ILE n 
1 250 LEU n 
1 251 GLY n 
1 252 PRO n 
1 253 LEU n 
1 254 SER n 
1 255 ALA n 
1 256 GLN n 
1 257 THR n 
1 258 GLY n 
1 259 ILE n 
1 260 ALA n 
1 261 VAL n 
1 262 LEU n 
1 263 ASP n 
1 264 MET n 
1 265 CYS n 
1 266 ALA n 
1 267 SER n 
1 268 LEU n 
1 269 LYS n 
1 270 GLU n 
1 271 LEU n 
1 272 LEU n 
1 273 GLN n 
1 274 ASN n 
1 275 GLY n 
1 276 MET n 
1 277 ASN n 
1 278 GLY n 
1 279 ARG n 
1 280 THR n 
1 281 ILE n 
1 282 LEU n 
1 283 GLY n 
1 284 SER n 
1 285 ALA n 
1 286 LEU n 
1 287 LEU n 
1 288 GLU n 
1 289 ASP n 
1 290 GLU n 
1 291 PHE n 
1 292 THR n 
1 293 PRO n 
1 294 PHE n 
1 295 ASP n 
1 296 VAL n 
1 297 VAL n 
1 298 ARG n 
1 299 GLN n 
1 300 CYS n 
1 301 SER n 
1 302 GLY n 
1 303 VAL n 
1 304 THR n 
1 305 PHE n 
1 306 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   306 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'rep, 1a-1b' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1   1   SER SER A . n 
A 1 2   GLY 2   2   2   GLY GLY A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ARG 4   4   4   ARG ARG A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   MET 6   6   6   MET MET A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  CYS 16  16  16  CYS CYS A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  THR 21  21  21  THR THR A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  ASN 28  28  28  ASN ASN A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  TRP 31  31  31  TRP TRP A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  ASP 34  34  34  ASP ASP A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  CYS 38  38  38  CYS CYS A . n 
A 1 39  PRO 39  39  39  PRO PRO A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  CYS 44  44  44  CYS CYS A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  MET 49  49  49  MET MET A . n 
A 1 50  LEU 50  50  50  LEU LEU A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  ASP 56  56  56  ASP ASP A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  HIS 64  64  64  HIS HIS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  MET 82  82  82  MET MET A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  CYS 85  85  85  CYS CYS A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  ASP 92  92  92  ASP ASP A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  PRO 99  99  99  PRO PRO A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ARG 105 105 105 ARG ARG A . n 
A 1 106 ILE 106 106 106 ILE ILE A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 PHE 134 134 134 PHE PHE A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 CYS 145 145 145 CYS CYS A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 ASP 153 153 153 ASP ASP A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 CYS 156 156 156 CYS CYS A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 CYS 160 160 160 CYS CYS A . n 
A 1 161 TYR 161 161 161 TYR TYR A . n 
A 1 162 MET 162 162 162 MET MET A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 MET 165 165 165 MET MET A . n 
A 1 166 GLU 166 166 166 GLU GLU A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 HIS 172 172 172 HIS HIS A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 GLN 189 189 189 GLN GLN A . n 
A 1 190 ILE 190 190 190 ILE ILE A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 GLN 192 192 192 GLN GLN A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 ILE 200 200 200 ILE ILE A . n 
A 1 201 THR 201 201 201 THR THR A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 TRP 207 207 207 TRP TRP A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ARG 217 217 217 ARG ARG A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ASN 221 221 221 ASN ASN A . n 
A 1 222 ARG 222 222 222 ARG ARG A . n 
A 1 223 PHE 223 223 223 PHE PHE A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 MET 235 235 235 MET MET A . n 
A 1 236 LYS 236 236 236 LYS LYS A . n 
A 1 237 TYR 237 237 237 TYR TYR A . n 
A 1 238 ASN 238 238 238 ASN ASN A . n 
A 1 239 TYR 239 239 239 TYR TYR A . n 
A 1 240 GLU 240 240 240 GLU GLU A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 THR 243 243 243 THR THR A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 ASP 248 248 248 ASP ASP A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 THR 257 257 257 THR THR A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 CYS 265 265 265 CYS CYS A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 LYS 269 269 269 LYS LYS A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 ASN 274 274 274 ASN ASN A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 ASN 277 277 277 ASN ASN A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 SER 284 284 284 SER SER A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 PHE 291 291 291 PHE PHE A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 PRO 293 293 293 PRO PRO A . n 
A 1 294 PHE 294 294 294 PHE PHE A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 VAL 296 296 296 VAL VAL A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLN 299 299 299 GLN GLN A . n 
A 1 300 CYS 300 300 300 CYS CYS A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 GLY 302 302 302 GLY GLY A . n 
A 1 303 VAL 303 303 ?   ?   ?   A . n 
A 1 304 THR 304 304 ?   ?   ?   A . n 
A 1 305 PHE 305 305 ?   ?   ?   A . n 
A 1 306 GLN 306 306 ?   ?   ?   A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 HOH 1   401 236 HOH HOH A . 
B 2 HOH 2   402 205 HOH HOH A . 
B 2 HOH 3   403 277 HOH HOH A . 
B 2 HOH 4   404 99  HOH HOH A . 
B 2 HOH 5   405 207 HOH HOH A . 
B 2 HOH 6   406 189 HOH HOH A . 
B 2 HOH 7   407 170 HOH HOH A . 
B 2 HOH 8   408 266 HOH HOH A . 
B 2 HOH 9   409 223 HOH HOH A . 
B 2 HOH 10  410 167 HOH HOH A . 
B 2 HOH 11  411 174 HOH HOH A . 
B 2 HOH 12  412 321 HOH HOH A . 
B 2 HOH 13  413 320 HOH HOH A . 
B 2 HOH 14  414 212 HOH HOH A . 
B 2 HOH 15  415 171 HOH HOH A . 
B 2 HOH 16  416 311 HOH HOH A . 
B 2 HOH 17  417 217 HOH HOH A . 
B 2 HOH 18  418 151 HOH HOH A . 
B 2 HOH 19  419 177 HOH HOH A . 
B 2 HOH 20  420 194 HOH HOH A . 
B 2 HOH 21  421 233 HOH HOH A . 
B 2 HOH 22  422 193 HOH HOH A . 
B 2 HOH 23  423 204 HOH HOH A . 
B 2 HOH 24  424 60  HOH HOH A . 
B 2 HOH 25  425 132 HOH HOH A . 
B 2 HOH 26  426 221 HOH HOH A . 
B 2 HOH 27  427 137 HOH HOH A . 
B 2 HOH 28  428 128 HOH HOH A . 
B 2 HOH 29  429 100 HOH HOH A . 
B 2 HOH 30  430 304 HOH HOH A . 
B 2 HOH 31  431 250 HOH HOH A . 
B 2 HOH 32  432 301 HOH HOH A . 
B 2 HOH 33  433 185 HOH HOH A . 
B 2 HOH 34  434 130 HOH HOH A . 
B 2 HOH 35  435 220 HOH HOH A . 
B 2 HOH 36  436 76  HOH HOH A . 
B 2 HOH 37  437 145 HOH HOH A . 
B 2 HOH 38  438 57  HOH HOH A . 
B 2 HOH 39  439 150 HOH HOH A . 
B 2 HOH 40  440 136 HOH HOH A . 
B 2 HOH 41  441 63  HOH HOH A . 
B 2 HOH 42  442 186 HOH HOH A . 
B 2 HOH 43  443 166 HOH HOH A . 
B 2 HOH 44  444 215 HOH HOH A . 
B 2 HOH 45  445 187 HOH HOH A . 
B 2 HOH 46  446 285 HOH HOH A . 
B 2 HOH 47  447 243 HOH HOH A . 
B 2 HOH 48  448 103 HOH HOH A . 
B 2 HOH 49  449 27  HOH HOH A . 
B 2 HOH 50  450 69  HOH HOH A . 
B 2 HOH 51  451 244 HOH HOH A . 
B 2 HOH 52  452 81  HOH HOH A . 
B 2 HOH 53  453 107 HOH HOH A . 
B 2 HOH 54  454 298 HOH HOH A . 
B 2 HOH 55  455 235 HOH HOH A . 
B 2 HOH 56  456 114 HOH HOH A . 
B 2 HOH 57  457 28  HOH HOH A . 
B 2 HOH 58  458 111 HOH HOH A . 
B 2 HOH 59  459 19  HOH HOH A . 
B 2 HOH 60  460 82  HOH HOH A . 
B 2 HOH 61  461 44  HOH HOH A . 
B 2 HOH 62  462 149 HOH HOH A . 
B 2 HOH 63  463 119 HOH HOH A . 
B 2 HOH 64  464 9   HOH HOH A . 
B 2 HOH 65  465 196 HOH HOH A . 
B 2 HOH 66  466 202 HOH HOH A . 
B 2 HOH 67  467 256 HOH HOH A . 
B 2 HOH 68  468 209 HOH HOH A . 
B 2 HOH 69  469 41  HOH HOH A . 
B 2 HOH 70  470 45  HOH HOH A . 
B 2 HOH 71  471 249 HOH HOH A . 
B 2 HOH 72  472 267 HOH HOH A . 
B 2 HOH 73  473 190 HOH HOH A . 
B 2 HOH 74  474 77  HOH HOH A . 
B 2 HOH 75  475 52  HOH HOH A . 
B 2 HOH 76  476 134 HOH HOH A . 
B 2 HOH 77  477 197 HOH HOH A . 
B 2 HOH 78  478 122 HOH HOH A . 
B 2 HOH 79  479 94  HOH HOH A . 
B 2 HOH 80  480 20  HOH HOH A . 
B 2 HOH 81  481 240 HOH HOH A . 
B 2 HOH 82  482 322 HOH HOH A . 
B 2 HOH 83  483 126 HOH HOH A . 
B 2 HOH 84  484 251 HOH HOH A . 
B 2 HOH 85  485 37  HOH HOH A . 
B 2 HOH 86  486 231 HOH HOH A . 
B 2 HOH 87  487 72  HOH HOH A . 
B 2 HOH 88  488 152 HOH HOH A . 
B 2 HOH 89  489 265 HOH HOH A . 
B 2 HOH 90  490 53  HOH HOH A . 
B 2 HOH 91  491 8   HOH HOH A . 
B 2 HOH 92  492 58  HOH HOH A . 
B 2 HOH 93  493 93  HOH HOH A . 
B 2 HOH 94  494 227 HOH HOH A . 
B 2 HOH 95  495 268 HOH HOH A . 
B 2 HOH 96  496 16  HOH HOH A . 
B 2 HOH 97  497 324 HOH HOH A . 
B 2 HOH 98  498 61  HOH HOH A . 
B 2 HOH 99  499 78  HOH HOH A . 
B 2 HOH 100 500 120 HOH HOH A . 
B 2 HOH 101 501 154 HOH HOH A . 
B 2 HOH 102 502 198 HOH HOH A . 
B 2 HOH 103 503 238 HOH HOH A . 
B 2 HOH 104 504 30  HOH HOH A . 
B 2 HOH 105 505 295 HOH HOH A . 
B 2 HOH 106 506 155 HOH HOH A . 
B 2 HOH 107 507 129 HOH HOH A . 
B 2 HOH 108 508 106 HOH HOH A . 
B 2 HOH 109 509 98  HOH HOH A . 
B 2 HOH 110 510 12  HOH HOH A . 
B 2 HOH 111 511 15  HOH HOH A . 
B 2 HOH 112 512 102 HOH HOH A . 
B 2 HOH 113 513 85  HOH HOH A . 
B 2 HOH 114 514 6   HOH HOH A . 
B 2 HOH 115 515 178 HOH HOH A . 
B 2 HOH 116 516 2   HOH HOH A . 
B 2 HOH 117 517 35  HOH HOH A . 
B 2 HOH 118 518 10  HOH HOH A . 
B 2 HOH 119 519 142 HOH HOH A . 
B 2 HOH 120 520 159 HOH HOH A . 
B 2 HOH 121 521 105 HOH HOH A . 
B 2 HOH 122 522 269 HOH HOH A . 
B 2 HOH 123 523 110 HOH HOH A . 
B 2 HOH 124 524 83  HOH HOH A . 
B 2 HOH 125 525 39  HOH HOH A . 
B 2 HOH 126 526 48  HOH HOH A . 
B 2 HOH 127 527 143 HOH HOH A . 
B 2 HOH 128 528 96  HOH HOH A . 
B 2 HOH 129 529 49  HOH HOH A . 
B 2 HOH 130 530 84  HOH HOH A . 
B 2 HOH 131 531 203 HOH HOH A . 
B 2 HOH 132 532 113 HOH HOH A . 
B 2 HOH 133 533 228 HOH HOH A . 
B 2 HOH 134 534 22  HOH HOH A . 
B 2 HOH 135 535 36  HOH HOH A . 
B 2 HOH 136 536 40  HOH HOH A . 
B 2 HOH 137 537 91  HOH HOH A . 
B 2 HOH 138 538 43  HOH HOH A . 
B 2 HOH 139 539 14  HOH HOH A . 
B 2 HOH 140 540 34  HOH HOH A . 
B 2 HOH 141 541 153 HOH HOH A . 
B 2 HOH 142 542 248 HOH HOH A . 
B 2 HOH 143 543 158 HOH HOH A . 
B 2 HOH 144 544 199 HOH HOH A . 
B 2 HOH 145 545 146 HOH HOH A . 
B 2 HOH 146 546 24  HOH HOH A . 
B 2 HOH 147 547 1   HOH HOH A . 
B 2 HOH 148 548 241 HOH HOH A . 
B 2 HOH 149 549 38  HOH HOH A . 
B 2 HOH 150 550 17  HOH HOH A . 
B 2 HOH 151 551 46  HOH HOH A . 
B 2 HOH 152 552 33  HOH HOH A . 
B 2 HOH 153 553 123 HOH HOH A . 
B 2 HOH 154 554 92  HOH HOH A . 
B 2 HOH 155 555 3   HOH HOH A . 
B 2 HOH 156 556 117 HOH HOH A . 
B 2 HOH 157 557 284 HOH HOH A . 
B 2 HOH 158 558 73  HOH HOH A . 
B 2 HOH 159 559 42  HOH HOH A . 
B 2 HOH 160 560 127 HOH HOH A . 
B 2 HOH 161 561 147 HOH HOH A . 
B 2 HOH 162 562 176 HOH HOH A . 
B 2 HOH 163 563 13  HOH HOH A . 
B 2 HOH 164 564 79  HOH HOH A . 
B 2 HOH 165 565 11  HOH HOH A . 
B 2 HOH 166 566 245 HOH HOH A . 
B 2 HOH 167 567 89  HOH HOH A . 
B 2 HOH 168 568 7   HOH HOH A . 
B 2 HOH 169 569 21  HOH HOH A . 
B 2 HOH 170 570 29  HOH HOH A . 
B 2 HOH 171 571 133 HOH HOH A . 
B 2 HOH 172 572 172 HOH HOH A . 
B 2 HOH 173 573 138 HOH HOH A . 
B 2 HOH 174 574 47  HOH HOH A . 
B 2 HOH 175 575 80  HOH HOH A . 
B 2 HOH 176 576 192 HOH HOH A . 
B 2 HOH 177 577 148 HOH HOH A . 
B 2 HOH 178 578 135 HOH HOH A . 
B 2 HOH 179 579 4   HOH HOH A . 
B 2 HOH 180 580 210 HOH HOH A . 
B 2 HOH 181 581 68  HOH HOH A . 
B 2 HOH 182 582 32  HOH HOH A . 
B 2 HOH 183 583 318 HOH HOH A . 
B 2 HOH 184 584 88  HOH HOH A . 
B 2 HOH 185 585 165 HOH HOH A . 
B 2 HOH 186 586 291 HOH HOH A . 
B 2 HOH 187 587 51  HOH HOH A . 
B 2 HOH 188 588 258 HOH HOH A . 
B 2 HOH 189 589 226 HOH HOH A . 
B 2 HOH 190 590 179 HOH HOH A . 
B 2 HOH 191 591 90  HOH HOH A . 
B 2 HOH 192 592 109 HOH HOH A . 
B 2 HOH 193 593 23  HOH HOH A . 
B 2 HOH 194 594 263 HOH HOH A . 
B 2 HOH 195 595 314 HOH HOH A . 
B 2 HOH 196 596 86  HOH HOH A . 
B 2 HOH 197 597 104 HOH HOH A . 
B 2 HOH 198 598 116 HOH HOH A . 
B 2 HOH 199 599 312 HOH HOH A . 
B 2 HOH 200 600 219 HOH HOH A . 
B 2 HOH 201 601 125 HOH HOH A . 
B 2 HOH 202 602 65  HOH HOH A . 
B 2 HOH 203 603 271 HOH HOH A . 
B 2 HOH 204 604 101 HOH HOH A . 
B 2 HOH 205 605 255 HOH HOH A . 
B 2 HOH 206 606 121 HOH HOH A . 
B 2 HOH 207 607 25  HOH HOH A . 
B 2 HOH 208 608 70  HOH HOH A . 
B 2 HOH 209 609 144 HOH HOH A . 
B 2 HOH 210 610 64  HOH HOH A . 
B 2 HOH 211 611 141 HOH HOH A . 
B 2 HOH 212 612 97  HOH HOH A . 
B 2 HOH 213 613 239 HOH HOH A . 
B 2 HOH 214 614 278 HOH HOH A . 
B 2 HOH 215 615 264 HOH HOH A . 
B 2 HOH 216 616 297 HOH HOH A . 
B 2 HOH 217 617 26  HOH HOH A . 
B 2 HOH 218 618 208 HOH HOH A . 
B 2 HOH 219 619 54  HOH HOH A . 
B 2 HOH 220 620 118 HOH HOH A . 
B 2 HOH 221 621 272 HOH HOH A . 
B 2 HOH 222 622 157 HOH HOH A . 
B 2 HOH 223 623 5   HOH HOH A . 
B 2 HOH 224 624 234 HOH HOH A . 
B 2 HOH 225 625 191 HOH HOH A . 
B 2 HOH 226 626 195 HOH HOH A . 
B 2 HOH 227 627 307 HOH HOH A . 
B 2 HOH 228 628 131 HOH HOH A . 
B 2 HOH 229 629 164 HOH HOH A . 
B 2 HOH 230 630 67  HOH HOH A . 
B 2 HOH 231 631 216 HOH HOH A . 
B 2 HOH 232 632 299 HOH HOH A . 
B 2 HOH 233 633 280 HOH HOH A . 
B 2 HOH 234 634 182 HOH HOH A . 
B 2 HOH 235 635 275 HOH HOH A . 
B 2 HOH 236 636 222 HOH HOH A . 
B 2 HOH 237 637 287 HOH HOH A . 
B 2 HOH 238 638 261 HOH HOH A . 
B 2 HOH 239 639 292 HOH HOH A . 
B 2 HOH 240 640 224 HOH HOH A . 
B 2 HOH 241 641 310 HOH HOH A . 
B 2 HOH 242 642 246 HOH HOH A . 
B 2 HOH 243 643 156 HOH HOH A . 
B 2 HOH 244 644 211 HOH HOH A . 
B 2 HOH 245 645 262 HOH HOH A . 
B 2 HOH 246 646 163 HOH HOH A . 
B 2 HOH 247 647 300 HOH HOH A . 
B 2 HOH 248 648 218 HOH HOH A . 
B 2 HOH 249 649 289 HOH HOH A . 
B 2 HOH 250 650 242 HOH HOH A . 
B 2 HOH 251 651 252 HOH HOH A . 
B 2 HOH 252 652 162 HOH HOH A . 
B 2 HOH 253 653 302 HOH HOH A . 
B 2 HOH 254 654 281 HOH HOH A . 
B 2 HOH 255 655 313 HOH HOH A . 
B 2 HOH 256 656 319 HOH HOH A . 
B 2 HOH 257 657 230 HOH HOH A . 
B 2 HOH 258 658 288 HOH HOH A . 
B 2 HOH 259 659 294 HOH HOH A . 
B 2 HOH 260 660 214 HOH HOH A . 
B 2 HOH 261 661 115 HOH HOH A . 
B 2 HOH 262 662 180 HOH HOH A . 
B 2 HOH 263 663 290 HOH HOH A . 
B 2 HOH 264 664 306 HOH HOH A . 
B 2 HOH 265 665 95  HOH HOH A . 
B 2 HOH 266 666 303 HOH HOH A . 
B 2 HOH 267 667 66  HOH HOH A . 
B 2 HOH 268 668 308 HOH HOH A . 
B 2 HOH 269 669 59  HOH HOH A . 
B 2 HOH 270 670 323 HOH HOH A . 
B 2 HOH 271 671 201 HOH HOH A . 
B 2 HOH 272 672 315 HOH HOH A . 
B 2 HOH 273 673 253 HOH HOH A . 
B 2 HOH 274 674 188 HOH HOH A . 
B 2 HOH 275 675 276 HOH HOH A . 
B 2 HOH 276 676 50  HOH HOH A . 
B 2 HOH 277 677 247 HOH HOH A . 
B 2 HOH 278 678 270 HOH HOH A . 
B 2 HOH 279 679 279 HOH HOH A . 
B 2 HOH 280 680 325 HOH HOH A . 
B 2 HOH 281 681 232 HOH HOH A . 
B 2 HOH 282 682 74  HOH HOH A . 
B 2 HOH 283 683 160 HOH HOH A . 
B 2 HOH 284 684 316 HOH HOH A . 
B 2 HOH 285 685 184 HOH HOH A . 
B 2 HOH 286 686 183 HOH HOH A . 
B 2 HOH 287 687 273 HOH HOH A . 
B 2 HOH 288 688 169 HOH HOH A . 
B 2 HOH 289 689 293 HOH HOH A . 
B 2 HOH 290 690 56  HOH HOH A . 
B 2 HOH 291 691 75  HOH HOH A . 
B 2 HOH 292 692 260 HOH HOH A . 
B 2 HOH 293 693 286 HOH HOH A . 
B 2 HOH 294 694 18  HOH HOH A . 
B 2 HOH 295 695 237 HOH HOH A . 
B 2 HOH 296 696 213 HOH HOH A . 
B 2 HOH 297 697 71  HOH HOH A . 
B 2 HOH 298 698 181 HOH HOH A . 
B 2 HOH 299 699 200 HOH HOH A . 
B 2 HOH 300 700 55  HOH HOH A . 
B 2 HOH 301 701 225 HOH HOH A . 
B 2 HOH 302 702 140 HOH HOH A . 
B 2 HOH 303 703 124 HOH HOH A . 
B 2 HOH 304 704 274 HOH HOH A . 
B 2 HOH 305 705 296 HOH HOH A . 
B 2 HOH 306 706 108 HOH HOH A . 
B 2 HOH 307 707 87  HOH HOH A . 
B 2 HOH 308 708 31  HOH HOH A . 
B 2 HOH 309 709 161 HOH HOH A . 
B 2 HOH 310 710 62  HOH HOH A . 
B 2 HOH 311 711 259 HOH HOH A . 
B 2 HOH 312 712 173 HOH HOH A . 
B 2 HOH 313 713 112 HOH HOH A . 
B 2 HOH 314 714 309 HOH HOH A . 
B 2 HOH 315 715 317 HOH HOH A . 
B 2 HOH 316 716 168 HOH HOH A . 
B 2 HOH 317 717 229 HOH HOH A . 
B 2 HOH 318 718 257 HOH HOH A . 
B 2 HOH 319 719 305 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A SER 46  ? OG  ? A SER 46  OG  
2  1 Y 1 A GLU 47  ? CG  ? A GLU 47  CG  
3  1 Y 1 A GLU 47  ? CD  ? A GLU 47  CD  
4  1 Y 1 A GLU 47  ? OE1 ? A GLU 47  OE1 
5  1 Y 1 A GLU 47  ? OE2 ? A GLU 47  OE2 
6  1 Y 1 A LEU 50  ? CG  ? A LEU 50  CG  
7  1 Y 1 A LEU 50  ? CD1 ? A LEU 50  CD1 
8  1 Y 1 A LEU 50  ? CD2 ? A LEU 50  CD2 
9  1 Y 1 A ASN 72  ? CG  ? A ASN 72  CG  
10 1 Y 1 A ASN 72  ? OD1 ? A ASN 72  OD1 
11 1 Y 1 A ASN 72  ? ND2 ? A ASN 72  ND2 
12 1 Y 1 A VAL 73  ? CG1 ? A VAL 73  CG1 
13 1 Y 1 A VAL 73  ? CG2 ? A VAL 73  CG2 
14 1 Y 1 A LYS 100 ? CG  ? A LYS 100 CG  
15 1 Y 1 A LYS 100 ? CD  ? A LYS 100 CD  
16 1 Y 1 A LYS 100 ? CE  ? A LYS 100 CE  
17 1 Y 1 A LYS 100 ? NZ  ? A LYS 100 NZ  
18 1 Y 1 A TYR 154 ? CG  ? A TYR 154 CG  
19 1 Y 1 A TYR 154 ? CD1 ? A TYR 154 CD1 
20 1 Y 1 A TYR 154 ? CD2 ? A TYR 154 CD2 
21 1 Y 1 A TYR 154 ? CE1 ? A TYR 154 CE1 
22 1 Y 1 A TYR 154 ? CE2 ? A TYR 154 CE2 
23 1 Y 1 A TYR 154 ? CZ  ? A TYR 154 CZ  
24 1 Y 1 A TYR 154 ? OH  ? A TYR 154 OH  
25 1 Y 1 A ARG 217 ? CG  ? A ARG 217 CG  
26 1 Y 1 A ARG 217 ? CD  ? A ARG 217 CD  
27 1 Y 1 A ARG 217 ? NE  ? A ARG 217 NE  
28 1 Y 1 A ARG 217 ? CZ  ? A ARG 217 CZ  
29 1 Y 1 A ARG 217 ? NH1 ? A ARG 217 NH1 
30 1 Y 1 A ARG 217 ? NH2 ? A ARG 217 NH2 
31 1 Y 1 A ARG 222 ? CG  ? A ARG 222 CG  
32 1 Y 1 A ARG 222 ? CD  ? A ARG 222 CD  
33 1 Y 1 A ARG 222 ? NE  ? A ARG 222 NE  
34 1 Y 1 A ARG 222 ? CZ  ? A ARG 222 CZ  
35 1 Y 1 A ARG 222 ? NH1 ? A ARG 222 NH1 
36 1 Y 1 A ARG 222 ? NH2 ? A ARG 222 NH2 
37 1 Y 1 A PHE 294 ? CG  ? A PHE 294 CG  
38 1 Y 1 A PHE 294 ? CD1 ? A PHE 294 CD1 
39 1 Y 1 A PHE 294 ? CD2 ? A PHE 294 CD2 
40 1 Y 1 A PHE 294 ? CE1 ? A PHE 294 CE1 
41 1 Y 1 A PHE 294 ? CE2 ? A PHE 294 CE2 
42 1 Y 1 A PHE 294 ? CZ  ? A PHE 294 CZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   101.062 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BNU 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     114.412 
_cell.length_a_esd                 ? 
_cell.length_b                     53.995 
_cell.length_b_esd                 ? 
_cell.length_c                     44.582 
_cell.length_c_esd                 ? 
_cell.volume                       270296.009 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BNU 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y' 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BNU 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.00 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          38.41 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M BIS-TRIS, 20% w/v Polyethylene glycol monomethyl ether 5,000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            294 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-07-28 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.919764 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSLS-II BEAMLINE 17-ID-2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.919764 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID-2 
_diffrn_source.pdbx_synchrotron_site       NSLS-II 
# 
_reflns.B_iso_Wilson_estimate                          20.13 
_reflns.entry_id                                       9BNU 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.55 
_reflns.d_resolution_low                               33.97 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     38532 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.50 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.3 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          9.05 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   0.999 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.1023 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.55 
_reflns_shell.d_res_low                                     1.607 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           0.99 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3776 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               6.0 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.506 
_reflns_shell.pdbx_CC_star                                  0.82 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          98.46 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.288 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               26.08 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9BNU 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.55 
_refine.ls_d_res_low                             33.97 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     38505 
_refine.ls_number_reflns_R_free                  1950 
_refine.ls_number_reflns_R_work                  36555 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.51 
_refine.ls_percent_reflns_R_free                 5.06 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1950 
_refine.ls_R_factor_R_free                       0.2307 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1931 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 25.9782 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2143 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.55 
_refine_hist.d_res_low                        33.97 
_refine_hist.number_atoms_solvent             319 
_refine_hist.number_atoms_total               2611 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2292 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0065  ? 2392 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8483  ? 3268 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0527  ? 374  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0069  ? 427  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 12.5087 ? 863  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.55 1.59  . . 123 2574 98.00  . . . . 0.3186 . . . . . . . . . . . 0.3512 
'X-RAY DIFFRACTION' 1.59 1.63  . . 135 2593 99.71  . . . . 0.2911 . . . . . . . . . . . 0.3282 
'X-RAY DIFFRACTION' 1.63 1.68  . . 133 2612 99.89  . . . . 0.2692 . . . . . . . . . . . 0.3130 
'X-RAY DIFFRACTION' 1.68 1.74  . . 142 2598 99.78  . . . . 0.2541 . . . . . . . . . . . 0.3101 
'X-RAY DIFFRACTION' 1.74 1.80  . . 145 2619 99.75  . . . . 0.2518 . . . . . . . . . . . 0.2596 
'X-RAY DIFFRACTION' 1.80 1.87  . . 134 2579 99.74  . . . . 0.2345 . . . . . . . . . . . 0.2821 
'X-RAY DIFFRACTION' 1.87 1.95  . . 144 2593 99.60  . . . . 0.2147 . . . . . . . . . . . 0.2667 
'X-RAY DIFFRACTION' 1.96 2.06  . . 138 2621 99.78  . . . . 0.2122 . . . . . . . . . . . 0.2743 
'X-RAY DIFFRACTION' 2.06 2.19  . . 146 2616 99.64  . . . . 0.2075 . . . . . . . . . . . 0.2424 
'X-RAY DIFFRACTION' 2.19 2.36  . . 135 2611 99.53  . . . . 0.2024 . . . . . . . . . . . 0.2408 
'X-RAY DIFFRACTION' 2.36 2.59  . . 152 2606 99.82  . . . . 0.2075 . . . . . . . . . . . 0.2577 
'X-RAY DIFFRACTION' 2.59 2.97  . . 150 2625 100.00 . . . . 0.1918 . . . . . . . . . . . 0.2305 
'X-RAY DIFFRACTION' 2.97 3.74  . . 137 2647 99.78  . . . . 0.1664 . . . . . . . . . . . 0.1944 
'X-RAY DIFFRACTION' 3.74 33.97 . . 136 2661 98.28  . . . . 0.1471 . . . . . . . . . . . 0.1752 
# 
_struct.entry_id                     9BNU 
_struct.title                        'Crystal Structure of T190I SARS-CoV-2 Main Protease' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BNU 
_struct_keywords.text            'Hydrolase, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1AB_SARS2 
_struct_ref.pdbx_db_accession          P0DTD1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_struct_ref.pdbx_align_begin           3264 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9BNU 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 306 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P0DTD1 
_struct_ref_seq.db_align_beg                  3264 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3569 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       306 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             9BNU 
_struct_ref_seq_dif.mon_id                       ILE 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      190 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   P0DTD1 
_struct_ref_seq_dif.db_mon_id                    THR 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          3453 
_struct_ref_seq_dif.details                      conflict 
_struct_ref_seq_dif.pdbx_auth_seq_num            190 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2740  ? 
1 MORE         -13   ? 
1 'SSA (A^2)'  24460 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000 0.0000000000 0.0000000000  0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000  
2 'crystal symmetry operation' 2_556 -x,y,-z+1 -1.0000000000 0.0000000000 0.0000000000 -8.5539976607 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 43.7536723947 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 10  ? GLY A 15  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 41  ? CYS A 44  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 GLU A 47  ? ASN A 51  ? GLU A 47  ASN A 51  5 ? 5  
HELX_P HELX_P4  AA4 ASN A 53  ? ARG A 60  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P5  AA5 SER A 62  ? HIS A 64  ? SER A 62  HIS A 64  5 ? 3  
HELX_P HELX_P6  AA6 ILE A 200 ? ASN A 214 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P7  AA7 THR A 226 ? TYR A 237 ? THR A 226 TYR A 237 1 ? 12 
HELX_P HELX_P8  AA8 THR A 243 ? LEU A 250 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P9  AA9 LEU A 250 ? GLY A 258 ? LEU A 250 GLY A 258 1 ? 9  
HELX_P HELX_P10 AB1 ALA A 260 ? GLY A 275 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P11 AB2 THR A 292 ? GLY A 302 ? THR A 292 GLY A 302 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 73  ? LEU A 75  ? VAL A 73  LEU A 75  
AA1 2 PHE A 66  ? ALA A 70  ? PHE A 66  ALA A 70  
AA1 3 MET A 17  ? CYS A 22  ? MET A 17  CYS A 22  
AA1 4 THR A 25  ? LEU A 32  ? THR A 25  LEU A 32  
AA1 5 VAL A 35  ? PRO A 39  ? VAL A 35  PRO A 39  
AA1 6 VAL A 86  ? VAL A 91  ? VAL A 86  VAL A 91  
AA1 7 VAL A 77  ? GLN A 83  ? VAL A 77  GLN A 83  
AA2 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA2 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA2 3 VAL A 148 ? ASP A 153 ? VAL A 148 ASP A 153 
AA2 4 THR A 111 ? TYR A 118 ? THR A 111 TYR A 118 
AA2 5 SER A 121 ? ALA A 129 ? SER A 121 ALA A 129 
AA3 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA3 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA3 3 HIS A 172 ? THR A 175 ? HIS A 172 THR A 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 73  ? O VAL A 73  N ALA A 70  ? N ALA A 70  
AA1 2 3 O LEU A 67  ? O LEU A 67  N THR A 21  ? N THR A 21  
AA1 3 4 N VAL A 20  ? N VAL A 20  O LEU A 27  ? O LEU A 27  
AA1 4 5 N LEU A 30  ? N LEU A 30  O TYR A 37  ? O TYR A 37  
AA1 5 6 N VAL A 36  ? N VAL A 36  O LEU A 89  ? O LEU A 89  
AA1 6 7 O LYS A 90  ? O LYS A 90  N ILE A 78  ? N ILE A 78  
AA2 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA2 2 3 O SER A 158 ? O SER A 158 N ASN A 151 ? N ASN A 151 
AA2 3 4 O PHE A 150 ? O PHE A 150 N SER A 113 ? N SER A 113 
AA2 4 5 N ALA A 116 ? N ALA A 116 O SER A 123 ? O SER A 123 
AA3 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA3 2 3 N MET A 165 ? N MET A 165 O ALA A 173 ? O ALA A 173 
# 
_pdbx_entry_details.entry_id                   9BNU 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 52.48   -133.98 
2 1 ASN A 51  ? ? -156.92 62.83   
3 1 ASN A 84  ? ? 50.80   -121.68 
4 1 TYR A 154 ? ? 56.97   -103.73 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 607 ? B HOH . 
2 1 A HOH 634 ? B HOH . 
3 1 A HOH 713 ? B HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 -x,y,-z         
3 x+1/2,y+1/2,z   
4 -x+1/2,y+1/2,-z 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 717 ? 5.94 . 
2 1 O ? A HOH 718 ? 6.01 . 
3 1 O ? A HOH 719 ? 6.30 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A VAL 303 ? A VAL 303 
2 1 Y 1 A THR 304 ? A THR 304 
3 1 Y 1 A PHE 305 ? A PHE 305 
4 1 Y 1 A GLN 306 ? A GLN 306 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' 'P30 GM133893' 1 
'Department of Energy (DOE, United States)'                                                'United States' KP1607011      2 
'Other government'                                                                         ?               DE-SC0012704   3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6Y2E 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'C 1 2 1' 
_space_group.name_Hall        'C 2y' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9BNU 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.008740 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.001709 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.018520 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.022855 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . SER A 1 1   ? -1.11971  -22.60594 38.86132  1.000 27.14879 ? 1   SER A N   1 
ATOM   2    C CA  . SER A 1 1   ? -1.82693  -21.49946 38.24449  1.000 24.90895 ? 1   SER A CA  1 
ATOM   3    C C   . SER A 1 1   ? -1.46372  -21.30359 36.76805  1.000 39.32554 ? 1   SER A C   1 
ATOM   4    O O   . SER A 1 1   ? -0.70470  -22.08270 36.18877  1.000 32.01640 ? 1   SER A O   1 
ATOM   5    C CB  . SER A 1 1   ? -1.55508  -20.20512 39.01030  1.000 41.88575 ? 1   SER A CB  1 
ATOM   6    O OG  . SER A 1 1   ? -0.28742  -19.67490 38.66248  1.000 48.57581 ? 1   SER A OG  1 
ATOM   7    N N   . GLY A 1 2   ? -2.00406  -20.24930 36.17818  1.000 42.71409 ? 2   GLY A N   1 
ATOM   8    C CA  . GLY A 1 2   ? -1.87632  -19.95082 34.76631  1.000 30.32199 ? 2   GLY A CA  1 
ATOM   9    C C   . GLY A 1 2   ? -3.10459  -20.39619 34.00037  1.000 30.56362 ? 2   GLY A C   1 
ATOM   10   O O   . GLY A 1 2   ? -3.78490  -21.36577 34.36563  1.000 28.66610 ? 2   GLY A O   1 
ATOM   11   N N   . PHE A 1 3   ? -3.38791  -19.69524 32.90386  1.000 28.59445 ? 3   PHE A N   1 
ATOM   12   C CA  . PHE A 1 3   ? -4.58642  -19.95405 32.11132  1.000 27.96269 ? 3   PHE A CA  1 
ATOM   13   C C   . PHE A 1 3   ? -4.22869  -20.02177 30.63501  1.000 24.00061 ? 3   PHE A C   1 
ATOM   14   O O   . PHE A 1 3   ? -3.72054  -19.05030 30.06462  1.000 32.53108 ? 3   PHE A O   1 
ATOM   15   C CB  . PHE A 1 3   ? -5.65301  -18.88497 32.36441  1.000 35.49511 ? 3   PHE A CB  1 
ATOM   16   C CG  . PHE A 1 3   ? -7.04443  -19.34632 32.04935  1.000 25.31167 ? 3   PHE A CG  1 
ATOM   17   C CD1 . PHE A 1 3   ? -7.68104  -20.26737 32.87726  1.000 25.70257 ? 3   PHE A CD1 1 
ATOM   18   C CD2 . PHE A 1 3   ? -7.71425  -18.86269 30.93305  1.000 24.70511 ? 3   PHE A CD2 1 
ATOM   19   C CE1 . PHE A 1 3   ? -8.95588  -20.70292 32.60512  1.000 27.87316 ? 3   PHE A CE1 1 
ATOM   20   C CE2 . PHE A 1 3   ? -9.00223  -19.29145 30.64751  1.000 26.20659 ? 3   PHE A CE2 1 
ATOM   21   C CZ  . PHE A 1 3   ? -9.62058  -20.21710 31.47876  1.000 26.89699 ? 3   PHE A CZ  1 
ATOM   22   N N   . ARG A 1 4   ? -4.52816  -21.16084 30.01155  1.000 25.59716 ? 4   ARG A N   1 
ATOM   23   C CA  . ARG A 1 4   ? -4.20232  -21.41372 28.61894  1.000 21.55116 ? 4   ARG A CA  1 
ATOM   24   C C   . ARG A 1 4   ? -5.44810  -21.86119 27.85991  1.000 17.90937 ? 4   ARG A C   1 
ATOM   25   O O   . ARG A 1 4   ? -6.34844  -22.48075 28.43242  1.000 22.88928 ? 4   ARG A O   1 
ATOM   26   C CB  . ARG A 1 4   ? -3.11273  -22.50041 28.50782  1.000 17.33273 ? 4   ARG A CB  1 
ATOM   27   C CG  . ARG A 1 4   ? -1.67746  -21.98410 28.73108  1.000 22.75122 ? 4   ARG A CG  1 
ATOM   28   C CD  . ARG A 1 4   ? -1.09578  -21.34131 27.46355  1.000 24.97690 ? 4   ARG A CD  1 
ATOM   29   N NE  . ARG A 1 4   ? 0.33666   -21.06229 27.58436  1.000 28.01689 ? 4   ARG A NE  1 
ATOM   30   C CZ  . ARG A 1 4   ? 1.08286   -20.60818 26.58572  1.000 36.77953 ? 4   ARG A CZ  1 
ATOM   31   N NH1 . ARG A 1 4   ? 0.58092   -20.45059 25.37013  1.000 25.23817 ? 4   ARG A NH1 1 
ATOM   32   N NH2 . ARG A 1 4   ? 2.35539   -20.28367 26.81427  1.000 21.55061 ? 4   ARG A NH2 1 
ATOM   33   N N   . LYS A 1 5   ? -5.49007  -21.54439 26.57105  1.000 21.09680 ? 5   LYS A N   1 
ATOM   34   C CA  . LYS A 1 5   ? -6.51056  -22.12737 25.70885  1.000 17.84378 ? 5   LYS A CA  1 
ATOM   35   C C   . LYS A 1 5   ? -6.14963  -23.58957 25.48392  1.000 22.17973 ? 5   LYS A C   1 
ATOM   36   O O   . LYS A 1 5   ? -5.19196  -23.90936 24.77630  1.000 29.44446 ? 5   LYS A O   1 
ATOM   37   C CB  . LYS A 1 5   ? -6.62880  -21.36253 24.39799  1.000 22.04757 ? 5   LYS A CB  1 
ATOM   38   C CG  . LYS A 1 5   ? -7.86496  -21.73483 23.61887  1.000 26.54582 ? 5   LYS A CG  1 
ATOM   39   C CD  . LYS A 1 5   ? -8.16030  -20.69842 22.57465  1.000 25.40555 ? 5   LYS A CD  1 
ATOM   40   C CE  . LYS A 1 5   ? -8.65843  -19.42759 23.21300  1.000 28.13128 ? 5   LYS A CE  1 
ATOM   41   N NZ  . LYS A 1 5   ? -9.00621  -18.45637 22.15475  1.000 29.72090 ? 5   LYS A NZ  1 
ATOM   42   N N   . MET A 1 6   ? -6.91512  -24.47495 26.09448  1.000 20.18607 ? 6   MET A N   1 
ATOM   43   C CA  . MET A 1 6   ? -6.51386  -25.85756 26.27044  1.000 16.51559 ? 6   MET A CA  1 
ATOM   44   C C   . MET A 1 6   ? -7.48396  -26.74582 25.51409  1.000 15.50683 ? 6   MET A C   1 
ATOM   45   O O   . MET A 1 6   ? -8.69811  -26.61200 25.67903  1.000 18.42410 ? 6   MET A O   1 
ATOM   46   C CB  . MET A 1 6   ? -6.49151  -26.19311 27.76141  1.000 24.02288 ? 6   MET A CB  1 
ATOM   47   C CG  . MET A 1 6   ? -6.27447  -27.61153 28.08500  1.000 26.16759 ? 6   MET A CG  1 
ATOM   48   S SD  . MET A 1 6   ? -5.82647  -27.68890 29.82391  1.000 39.35142 ? 6   MET A SD  1 
ATOM   49   C CE  . MET A 1 6   ? -4.69043  -26.31876 29.91632  1.000 25.54062 ? 6   MET A CE  1 
ATOM   50   N N   . ALA A 1 7   ? -6.94649  -27.63563 24.69036  1.000 17.07586 ? 7   ALA A N   1 
ATOM   51   C CA  . ALA A 1 7   ? -7.75601  -28.62608 24.00081  1.000 15.53982 ? 7   ALA A CA  1 
ATOM   52   C C   . ALA A 1 7   ? -7.87591  -29.87818 24.85532  1.000 17.78588 ? 7   ALA A C   1 
ATOM   53   O O   . ALA A 1 7   ? -7.08091  -30.11769 25.76599  1.000 16.86763 ? 7   ALA A O   1 
ATOM   54   C CB  . ALA A 1 7   ? -7.14747  -28.98174 22.65126  1.000 20.24275 ? 7   ALA A CB  1 
ATOM   55   N N   . PHE A 1 8   ? -8.91150  -30.66128 24.58232  1.000 15.66413 ? 8   PHE A N   1 
ATOM   56   C CA  . PHE A 1 8   ? -9.01688  -31.96875 25.20391  1.000 18.41687 ? 8   PHE A CA  1 
ATOM   57   C C   . PHE A 1 8   ? -7.92991  -32.89696 24.67097  1.000 15.30854 ? 8   PHE A C   1 
ATOM   58   O O   . PHE A 1 8   ? -7.48288  -32.75355 23.53115  1.000 17.35776 ? 8   PHE A O   1 
ATOM   59   C CB  . PHE A 1 8   ? -10.38186 -32.59332 24.92417  1.000 16.98848 ? 8   PHE A CB  1 
ATOM   60   C CG  . PHE A 1 8   ? -11.50049 -31.94639 25.67318  1.000 21.74065 ? 8   PHE A CG  1 
ATOM   61   C CD1 . PHE A 1 8   ? -11.70677 -32.23294 27.00839  1.000 24.63535 ? 8   PHE A CD1 1 
ATOM   62   C CD2 . PHE A 1 8   ? -12.35189 -31.05566 25.04353  1.000 22.86342 ? 8   PHE A CD2 1 
ATOM   63   C CE1 . PHE A 1 8   ? -12.73958 -31.63957 27.70675  1.000 28.88663 ? 8   PHE A CE1 1 
ATOM   64   C CE2 . PHE A 1 8   ? -13.38251 -30.45915 25.74150  1.000 33.26566 ? 8   PHE A CE2 1 
ATOM   65   C CZ  . PHE A 1 8   ? -13.57592 -30.75601 27.06974  1.000 28.89808 ? 8   PHE A CZ  1 
ATOM   66   N N   . PRO A 1 9   ? -7.48505  -33.86069 25.48120  1.000 16.70447 ? 9   PRO A N   1 
ATOM   67   C CA  . PRO A 1 9   ? -6.55145  -34.86984 24.95944  1.000 14.42887 ? 9   PRO A CA  1 
ATOM   68   C C   . PRO A 1 9   ? -7.20526  -35.60323 23.79602  1.000 14.39859 ? 9   PRO A C   1 
ATOM   69   O O   . PRO A 1 9   ? -8.36501  -36.00480 23.87260  1.000 21.06475 ? 9   PRO A O   1 
ATOM   70   C CB  . PRO A 1 9   ? -6.30624  -35.79346 26.15726  1.000 21.81749 ? 9   PRO A CB  1 
ATOM   71   C CG  . PRO A 1 9   ? -6.77888  -35.03697 27.35361  1.000 22.10435 ? 9   PRO A CG  1 
ATOM   72   C CD  . PRO A 1 9   ? -7.88749  -34.12689 26.86597  1.000 17.56808 ? 9   PRO A CD  1 
ATOM   73   N N   . SER A 1 10  ? -6.46357  -35.75024 22.71542  1.000 15.97192 ? 10  SER A N   1 
ATOM   74   C CA  . SER A 1 10  ? -7.05636  -36.15778 21.44211  1.000 15.62205 ? 10  SER A CA  1 
ATOM   75   C C   . SER A 1 10  ? -6.95913  -37.65457 21.16058  1.000 16.87943 ? 10  SER A C   1 
ATOM   76   O O   . SER A 1 10  ? -7.46318  -38.10463 20.12596  1.000 15.97997 ? 10  SER A O   1 
ATOM   77   C CB  . SER A 1 10  ? -6.41794  -35.37177 20.29043  1.000 17.67431 ? 10  SER A CB  1 
ATOM   78   O OG  . SER A 1 10  ? -5.00354  -35.58940 20.16389  1.000 18.47083 ? 10  SER A OG  1 
ATOM   79   N N   . GLY A 1 11  ? -6.34520  -38.43802 22.05251  1.000 20.20300 ? 11  GLY A N   1 
ATOM   80   C CA  . GLY A 1 11  ? -6.03856  -39.82114 21.70913  1.000 15.51856 ? 11  GLY A CA  1 
ATOM   81   C C   . GLY A 1 11  ? -7.25041  -40.66682 21.35384  1.000 15.02762 ? 11  GLY A C   1 
ATOM   82   O O   . GLY A 1 11  ? -7.18575  -41.49511 20.44331  1.000 19.05954 ? 11  GLY A O   1 
ATOM   83   N N   . LYS A 1 12  ? -8.34793  -40.51092 22.10392  1.000 15.24761 ? 12  LYS A N   1 
ATOM   84   C CA  . LYS A 1 12  ? -9.53733  -41.30843 21.84213  1.000 16.98831 ? 12  LYS A CA  1 
ATOM   85   C C   . LYS A 1 12  ? -10.11184 -41.00384 20.47106  1.000 19.75147 ? 12  LYS A C   1 
ATOM   86   O O   . LYS A 1 12  ? -10.71067 -41.88314 19.84352  1.000 20.07402 ? 12  LYS A O   1 
ATOM   87   C CB  . LYS A 1 12  ? -10.59767 -41.05467 22.90795  1.000 16.50749 ? 12  LYS A CB  1 
ATOM   88   C CG  . LYS A 1 12  ? -10.24290 -41.56127 24.30556  1.000 20.11506 ? 12  LYS A CG  1 
ATOM   89   C CD  . LYS A 1 12  ? -11.12886 -40.89731 25.34801  1.000 28.35477 ? 12  LYS A CD  1 
ATOM   90   C CE  . LYS A 1 12  ? -10.76988 -41.33979 26.75441  1.000 46.57365 ? 12  LYS A CE  1 
ATOM   91   N NZ  . LYS A 1 12  ? -11.35682 -42.66971 27.05331  1.000 41.82879 ? 12  LYS A NZ  1 
ATOM   92   N N   . VAL A 1 13  ? -9.93306  -39.77564 19.98550  1.000 16.66221 ? 13  VAL A N   1 
ATOM   93   C CA  . VAL A 1 13  ? -10.42067 -39.44315 18.64639  1.000 14.80301 ? 13  VAL A CA  1 
ATOM   94   C C   . VAL A 1 13  ? -9.41415  -39.88153 17.58688  1.000 14.81773 ? 13  VAL A C   1 
ATOM   95   O O   . VAL A 1 13  ? -9.79219  -40.30075 16.47929  1.000 15.65172 ? 13  VAL A O   1 
ATOM   96   C CB  . VAL A 1 13  ? -10.72394 -37.93711 18.57012  1.000 13.27218 ? 13  VAL A CB  1 
ATOM   97   C CG1 . VAL A 1 13  ? -11.20694 -37.55791 17.13737  1.000 13.95598 ? 13  VAL A CG1 1 
ATOM   98   C CG2 . VAL A 1 13  ? -11.75870 -37.56216 19.60796  1.000 15.63766 ? 13  VAL A CG2 1 
ATOM   99   N N   . GLU A 1 14  ? -8.11761  -39.80635 17.90286  1.000 15.75364 ? 14  GLU A N   1 
ATOM   100  C CA  . GLU A 1 14  ? -7.09878  -40.22978 16.95092  1.000 17.09838 ? 14  GLU A CA  1 
ATOM   101  C C   . GLU A 1 14  ? -7.33566  -41.65733 16.48628  1.000 15.90116 ? 14  GLU A C   1 
ATOM   102  O O   . GLU A 1 14  ? -7.18897  -41.96357 15.29752  1.000 15.74833 ? 14  GLU A O   1 
ATOM   103  C CB  . GLU A 1 14  ? -5.71475  -40.12439 17.58727  1.000 15.56619 ? 14  GLU A CB  1 
ATOM   104  C CG  . GLU A 1 14  ? -5.17792  -38.71061 17.71528  1.000 15.75521 ? 14  GLU A CG  1 
ATOM   105  C CD  . GLU A 1 14  ? -3.94102  -38.67256 18.58341  1.000 20.16841 ? 14  GLU A CD  1 
ATOM   106  O OE1 . GLU A 1 14  ? -2.99904  -39.42013 18.26026  1.000 22.96476 ? 14  GLU A OE1 1 
ATOM   107  O OE2 . GLU A 1 14  ? -3.92967  -37.93906 19.59144  1.000 21.88305 ? 14  GLU A OE2 1 
ATOM   108  N N   . GLY A 1 15  ? -7.68804  -42.53855 17.42568  1.000 17.74594 ? 15  GLY A N   1 
ATOM   109  C CA  . GLY A 1 15  ? -7.95543  -43.93172 17.11550  1.000 19.10488 ? 15  GLY A CA  1 
ATOM   110  C C   . GLY A 1 15  ? -9.15105  -44.14716 16.22004  1.000 23.96908 ? 15  GLY A C   1 
ATOM   111  O O   . GLY A 1 15  ? -9.37979  -45.27985 15.78385  1.000 20.10597 ? 15  GLY A O   1 
ATOM   112  N N   . CYS A 1 16  ? -9.92317  -43.10021 15.94552  1.000 17.19840 ? 16  CYS A N   1 
ATOM   113  C CA  . CYS A 1 16  ? -11.10249 -43.20557 15.10043  1.000 16.96560 ? 16  CYS A CA  1 
ATOM   114  C C   . CYS A 1 16  ? -10.91568 -42.60231 13.72314  1.000 16.48562 ? 16  CYS A C   1 
ATOM   115  O O   . CYS A 1 16  ? -11.82840 -42.70990 12.89039  1.000 17.75539 ? 16  CYS A O   1 
ATOM   116  C CB  . CYS A 1 16  ? -12.30286 -42.51574 15.77422  1.000 17.64222 ? 16  CYS A CB  1 
ATOM   117  S SG  . CYS A 1 16  ? -12.74132 -43.18154 17.38900  1.000 21.89701 ? 16  CYS A SG  1 
ATOM   118  N N   . MET A 1 17  ? -9.78527  -41.96404 13.44829  1.000 16.27535 ? 17  MET A N   1 
ATOM   119  C CA  . MET A 1 17  ? -9.64471  -41.27517 12.17389  1.000 18.08088 ? 17  MET A CA  1 
ATOM   120  C C   . MET A 1 17  ? -9.22284  -42.24290 11.08628  1.000 22.75846 ? 17  MET A C   1 
ATOM   121  O O   . MET A 1 17  ? -8.32955  -43.07380 11.27380  1.000 20.92321 ? 17  MET A O   1 
ATOM   122  C CB  . MET A 1 17  ? -8.64205  -40.11878 12.27481  1.000 20.74492 ? 17  MET A CB  1 
ATOM   123  C CG  . MET A 1 17  ? -9.02951  -39.07430 13.29543  1.000 18.39224 ? 17  MET A CG  1 
ATOM   124  S SD  . MET A 1 17  ? -10.72876 -38.47730 13.09484  1.000 16.94591 ? 17  MET A SD  1 
ATOM   125  C CE  . MET A 1 17  ? -10.75162 -37.83620 11.39873  1.000 18.84713 ? 17  MET A CE  1 
ATOM   126  N N   . VAL A 1 18  ? -9.88621  -42.14019 9.94296   1.000 17.21665 ? 18  VAL A N   1 
ATOM   127  C CA  . VAL A 1 18  ? -9.57592  -42.96828 8.78625   1.000 23.50816 ? 18  VAL A CA  1 
ATOM   128  C C   . VAL A 1 18  ? -9.55004  -42.08306 7.54767   1.000 23.84931 ? 18  VAL A C   1 
ATOM   129  O O   . VAL A 1 18  ? -9.99557  -40.93372 7.55869   1.000 18.74900 ? 18  VAL A O   1 
ATOM   130  C CB  . VAL A 1 18  ? -10.57821 -44.13434 8.60538   1.000 20.85705 ? 18  VAL A CB  1 
ATOM   131  C CG1 . VAL A 1 18  ? -10.59519 -45.02538 9.84756   1.000 23.71645 ? 18  VAL A CG1 1 
ATOM   132  C CG2 . VAL A 1 18  ? -11.97334 -43.59882 8.33294   1.000 17.29815 ? 18  VAL A CG2 1 
ATOM   133  N N   . GLN A 1 19  ? -8.99976  -42.64264 6.47775   1.000 23.62376 ? 19  GLN A N   1 
ATOM   134  C CA  . GLN A 1 19  ? -8.95722  -42.01801 5.16786   1.000 21.81234 ? 19  GLN A CA  1 
ATOM   135  C C   . GLN A 1 19  ? -10.09829 -42.59036 4.33791   1.000 21.20076 ? 19  GLN A C   1 
ATOM   136  O O   . GLN A 1 19  ? -10.31079 -43.80648 4.32743   1.000 24.05366 ? 19  GLN A O   1 
ATOM   137  C CB  . GLN A 1 19  ? -7.60555  -42.29788 4.49893   1.000 24.50049 ? 19  GLN A CB  1 
ATOM   138  C CG  . GLN A 1 19  ? -7.39110  -41.55941 3.20473   1.000 28.31328 ? 19  GLN A CG  1 
ATOM   139  C CD  . GLN A 1 19  ? -6.19535  -42.09106 2.44573   1.000 41.49749 ? 19  GLN A CD  1 
ATOM   140  O OE1 . GLN A 1 19  ? -6.16565  -43.25930 2.04797   1.000 45.25102 ? 19  GLN A OE1 1 
ATOM   141  N NE2 . GLN A 1 19  ? -5.19413  -41.24205 2.25318   1.000 40.59108 ? 19  GLN A NE2 1 
ATOM   142  N N   . VAL A 1 20  ? -10.85469 -41.72104 3.67543   1.000 19.91412 ? 20  VAL A N   1 
ATOM   143  C CA  . VAL A 1 20  ? -11.92620 -42.14883 2.78688   1.000 17.24385 ? 20  VAL A CA  1 
ATOM   144  C C   . VAL A 1 20  ? -11.63102 -41.61788 1.39532   1.000 20.76668 ? 20  VAL A C   1 
ATOM   145  O O   . VAL A 1 20  ? -11.42638 -40.41253 1.21078   1.000 20.88493 ? 20  VAL A O   1 
ATOM   146  C CB  . VAL A 1 20  ? -13.30989 -41.65593 3.25007   1.000 19.59268 ? 20  VAL A CB  1 
ATOM   147  C CG1 . VAL A 1 20  ? -14.37726 -42.13617 2.25787   1.000 23.24431 ? 20  VAL A CG1 1 
ATOM   148  C CG2 . VAL A 1 20  ? -13.61751 -42.12051 4.67450   1.000 20.04604 ? 20  VAL A CG2 1 
ATOM   149  N N   . THR A 1 21  ? -11.65216 -42.50842 0.41144   1.000 21.96293 ? 21  THR A N   1 
ATOM   150  C CA  . THR A 1 21  ? -11.39630 -42.13065 -0.96904  1.000 25.47625 ? 21  THR A CA  1 
ATOM   151  C C   . THR A 1 21  ? -12.55611 -42.60293 -1.82845  1.000 25.90239 ? 21  THR A C   1 
ATOM   152  O O   . THR A 1 21  ? -13.01465 -43.74225 -1.69977  1.000 29.29855 ? 21  THR A O   1 
ATOM   153  C CB  . THR A 1 21  ? -10.05974 -42.71492 -1.46669  1.000 29.78635 ? 21  THR A CB  1 
ATOM   154  O OG1 . THR A 1 21  ? -8.97996  -42.06142 -0.79388  1.000 31.63166 ? 21  THR A OG1 1 
ATOM   155  C CG2 . THR A 1 21  ? -9.89879  -42.51100 -2.95415  1.000 34.75264 ? 21  THR A CG2 1 
ATOM   156  N N   . CYS A 1 22  ? -13.05409 -41.71352 -2.67086  1.000 25.08522 ? 22  CYS A N   1 
ATOM   157  C CA  . CYS A 1 22  ? -14.10437 -42.05832 -3.61786  1.000 23.83025 ? 22  CYS A CA  1 
ATOM   158  C C   . CYS A 1 22  ? -13.70408 -41.43119 -4.94236  1.000 38.78966 ? 22  CYS A C   1 
ATOM   159  O O   . CYS A 1 22  ? -13.66883 -40.20298 -5.05895  1.000 35.65635 ? 22  CYS A O   1 
ATOM   160  C CB  . CYS A 1 22  ? -15.47295 -41.55849 -3.15122  1.000 22.14617 ? 22  CYS A CB  1 
ATOM   161  S SG  . CYS A 1 22  ? -16.83974 -42.20087 -4.17611  1.000 33.44803 ? 22  CYS A SG  1 
ATOM   162  N N   . GLY A 1 23  ? -13.36850 -42.26426 -5.91694  1.000 36.95835 ? 23  GLY A N   1 
ATOM   163  C CA  . GLY A 1 23  ? -12.85700 -41.73961 -7.16983  1.000 30.64546 ? 23  GLY A CA  1 
ATOM   164  C C   . GLY A 1 23  ? -11.56287 -40.99892 -6.92718  1.000 33.32855 ? 23  GLY A C   1 
ATOM   165  O O   . GLY A 1 23  ? -10.57476 -41.56527 -6.44365  1.000 46.76921 ? 23  GLY A O   1 
ATOM   166  N N   . THR A 1 24  ? -11.56751 -39.70178 -7.22158  1.000 40.17113 ? 24  THR A N   1 
ATOM   167  C CA  . THR A 1 24  ? -10.36776 -38.88574 -7.11498  1.000 33.24764 ? 24  THR A CA  1 
ATOM   168  C C   . THR A 1 24  ? -10.27414 -38.10872 -5.80452  1.000 34.08739 ? 24  THR A C   1 
ATOM   169  O O   . THR A 1 24  ? -9.23616  -37.49792 -5.53623  1.000 39.32406 ? 24  THR A O   1 
ATOM   170  C CB  . THR A 1 24  ? -10.30294 -37.91521 -8.30201  1.000 43.36269 ? 24  THR A CB  1 
ATOM   171  O OG1 . THR A 1 24  ? -9.16422  -37.05437 -8.16686  1.000 67.77526 ? 24  THR A OG1 1 
ATOM   172  C CG2 . THR A 1 24  ? -11.57800 -37.07921 -8.37969  1.000 48.64227 ? 24  THR A CG2 1 
ATOM   173  N N   . THR A 1 25  ? -11.31009 -38.12928 -4.97756  1.000 36.88801 ? 25  THR A N   1 
ATOM   174  C CA  . THR A 1 25  ? -11.38230 -37.28380 -3.79292  1.000 31.44160 ? 25  THR A CA  1 
ATOM   175  C C   . THR A 1 25  ? -11.03230 -38.08700 -2.54541  1.000 19.88278 ? 25  THR A C   1 
ATOM   176  O O   . THR A 1 25  ? -11.53490 -39.20173 -2.35261  1.000 30.32710 ? 25  THR A O   1 
ATOM   177  C CB  . THR A 1 25  ? -12.78082 -36.67817 -3.66498  1.000 32.78945 ? 25  THR A CB  1 
ATOM   178  O OG1 . THR A 1 25  ? -13.06077 -35.88143 -4.82563  1.000 39.45424 ? 25  THR A OG1 1 
ATOM   179  C CG2 . THR A 1 25  ? -12.89785 -35.81954 -2.39885  1.000 26.58664 ? 25  THR A CG2 1 
ATOM   180  N N   . THR A 1 26  ? -10.17276 -37.52322 -1.70515  1.000 26.38365 ? 26  THR A N   1 
ATOM   181  C CA  A THR A 1 26  ? -9.77602  -38.15594 -0.45586  0.500 22.01802 ? 26  THR A CA  1 
ATOM   182  C CA  B THR A 1 26  ? -9.76711  -38.15309 -0.45600  0.500 22.01948 ? 26  THR A CA  1 
ATOM   183  C C   . THR A 1 26  ? -9.96226  -37.16610 0.68580   1.000 22.65344 ? 26  THR A C   1 
ATOM   184  O O   . THR A 1 26  ? -9.47064  -36.03466 0.62659   1.000 26.53607 ? 26  THR A O   1 
ATOM   185  C CB  A THR A 1 26  ? -8.32285  -38.65361 -0.51182  0.500 25.09919 ? 26  THR A CB  1 
ATOM   186  C CB  B THR A 1 26  ? -8.30582  -38.61710 -0.51102  0.500 25.04399 ? 26  THR A CB  1 
ATOM   187  O OG1 A THR A 1 26  ? -7.92488  -39.13230 0.77981   0.500 30.58727 ? 26  THR A OG1 1 
ATOM   188  O OG1 B THR A 1 26  ? -8.19950  -39.77284 -1.35515  0.500 18.41193 ? 26  THR A OG1 1 
ATOM   189  C CG2 A THR A 1 26  ? -7.37172  -37.55250 -0.98219  0.500 30.21912 ? 26  THR A CG2 1 
ATOM   190  C CG2 B THR A 1 26  ? -7.80663  -38.96999 0.87497   0.500 31.46059 ? 26  THR A CG2 1 
ATOM   191  N N   . LEU A 1 27  ? -10.68988 -37.58116 1.70990   1.000 21.12063 ? 27  LEU A N   1 
ATOM   192  C CA  . LEU A 1 27  ? -10.81146 -36.75400 2.89055   1.000 24.76182 ? 27  LEU A CA  1 
ATOM   193  C C   . LEU A 1 27  ? -10.82076 -37.67129 4.10370   1.000 22.64204 ? 27  LEU A C   1 
ATOM   194  O O   . LEU A 1 27  ? -10.53784 -38.87061 4.01146   1.000 19.39451 ? 27  LEU A O   1 
ATOM   195  C CB  . LEU A 1 27  ? -12.04337 -35.84168 2.79913   1.000 23.70644 ? 27  LEU A CB  1 
ATOM   196  C CG  . LEU A 1 27  ? -13.36365 -36.40965 2.29342   1.000 18.84585 ? 27  LEU A CG  1 
ATOM   197  C CD1 . LEU A 1 27  ? -13.95040 -37.48107 3.21238   1.000 22.34542 ? 27  LEU A CD1 1 
ATOM   198  C CD2 . LEU A 1 27  ? -14.37270 -35.27067 2.07875   1.000 17.02589 ? 27  LEU A CD2 1 
ATOM   199  N N   . ASN A 1 28  ? -11.16281 -37.10415 5.24786   1.000 18.72645 ? 28  ASN A N   1 
ATOM   200  C CA  . ASN A 1 28  ? -11.11163 -37.82019 6.50750   1.000 14.73343 ? 28  ASN A CA  1 
ATOM   201  C C   . ASN A 1 28  ? -12.47326 -38.39408 6.86517   1.000 16.69450 ? 28  ASN A C   1 
ATOM   202  O O   . ASN A 1 28  ? -13.51024 -37.79293 6.57655   1.000 17.47847 ? 28  ASN A O   1 
ATOM   203  C CB  . ASN A 1 28  ? -10.63019 -36.87988 7.61487   1.000 18.16180 ? 28  ASN A CB  1 
ATOM   204  C CG  . ASN A 1 28  ? -9.29611  -36.25906 7.29507   1.000 18.39916 ? 28  ASN A CG  1 
ATOM   205  O OD1 . ASN A 1 28  ? -8.27447  -36.92049 7.39991   1.000 16.62804 ? 28  ASN A OD1 1 
ATOM   206  N ND2 . ASN A 1 28  ? -9.29348  -34.98902 6.90551   1.000 16.51034 ? 28  ASN A ND2 1 
ATOM   207  N N   . GLY A 1 29  ? -12.45347 -39.57907 7.48809   1.000 16.44284 ? 29  GLY A N   1 
ATOM   208  C CA  . GLY A 1 29  ? -13.65172 -40.16211 8.04147   1.000 19.04145 ? 29  GLY A CA  1 
ATOM   209  C C   . GLY A 1 29  ? -13.47252 -40.51294 9.50817   1.000 14.45138 ? 29  GLY A C   1 
ATOM   210  O O   . GLY A 1 29  ? -12.36436 -40.57971 10.02983  1.000 15.95622 ? 29  GLY A O   1 
ATOM   211  N N   . LEU A 1 30  ? -14.59740 -40.70880 10.16593  1.000 14.08906 ? 30  LEU A N   1 
ATOM   212  C CA  . LEU A 1 30  ? -14.67458 -41.03576 11.58439  1.000 16.31017 ? 30  LEU A CA  1 
ATOM   213  C C   . LEU A 1 30  ? -15.25549 -42.44099 11.70745  1.000 21.36910 ? 30  LEU A C   1 
ATOM   214  O O   . LEU A 1 30  ? -16.40819 -42.68256 11.32969  1.000 18.66993 ? 30  LEU A O   1 
ATOM   215  C CB  . LEU A 1 30  ? -15.53723 -40.00903 12.31832  1.000 15.26096 ? 30  LEU A CB  1 
ATOM   216  C CG  . LEU A 1 30  ? -15.57890 -40.13999 13.83764  1.000 16.51378 ? 30  LEU A CG  1 
ATOM   217  C CD1 . LEU A 1 30  ? -14.23494 -39.68230 14.41801  1.000 14.90111 ? 30  LEU A CD1 1 
ATOM   218  C CD2 . LEU A 1 30  ? -16.74092 -39.36681 14.41324  1.000 16.99125 ? 30  LEU A CD2 1 
ATOM   219  N N   . TRP A 1 31  ? -14.45079 -43.36282 12.21816  1.000 16.86964 ? 31  TRP A N   1 
ATOM   220  C CA  . TRP A 1 31  ? -14.79471 -44.78511 12.30551  1.000 13.48142 ? 31  TRP A CA  1 
ATOM   221  C C   . TRP A 1 31  ? -15.19007 -45.12308 13.73921  1.000 16.91481 ? 31  TRP A C   1 
ATOM   222  O O   . TRP A 1 31  ? -14.33374 -45.16543 14.62946  1.000 16.96262 ? 31  TRP A O   1 
ATOM   223  C CB  . TRP A 1 31  ? -13.60450 -45.62987 11.85917  1.000 17.64242 ? 31  TRP A CB  1 
ATOM   224  C CG  . TRP A 1 31  ? -13.81469 -47.12683 11.89185  1.000 22.90717 ? 31  TRP A CG  1 
ATOM   225  C CD1 . TRP A 1 31  ? -15.00782 -47.80047 11.89302  1.000 20.72103 ? 31  TRP A CD1 1 
ATOM   226  C CD2 . TRP A 1 31  ? -12.78822 -48.12898 11.91160  1.000 28.72642 ? 31  TRP A CD2 1 
ATOM   227  N NE1 . TRP A 1 31  ? -14.78260 -49.16228 11.91705  1.000 20.49367 ? 31  TRP A NE1 1 
ATOM   228  C CE2 . TRP A 1 31  ? -13.43049 -49.38910 11.91979  1.000 23.90575 ? 31  TRP A CE2 1 
ATOM   229  C CE3 . TRP A 1 31  ? -11.39190 -48.08374 11.90817  1.000 28.21002 ? 31  TRP A CE3 1 
ATOM   230  C CZ2 . TRP A 1 31  ? -12.71666 -50.59297 11.93869  1.000 24.61925 ? 31  TRP A CZ2 1 
ATOM   231  C CZ3 . TRP A 1 31  ? -10.68582 -49.27980 11.93201  1.000 37.26171 ? 31  TRP A CZ3 1 
ATOM   232  C CH2 . TRP A 1 31  ? -11.35110 -50.51459 11.94727  1.000 24.93635 ? 31  TRP A CH2 1 
ATOM   233  N N   . LEU A 1 32  ? -16.48230 -45.36538 13.95662  1.000 16.69399 ? 32  LEU A N   1 
ATOM   234  C CA  . LEU A 1 32  ? -17.05731 -45.67198 15.25812  1.000 21.25926 ? 32  LEU A CA  1 
ATOM   235  C C   . LEU A 1 32  ? -17.90703 -46.92050 15.12188  1.000 23.27093 ? 32  LEU A C   1 
ATOM   236  O O   . LEU A 1 32  ? -18.79634 -46.96157 14.26266  1.000 19.99244 ? 32  LEU A O   1 
ATOM   237  C CB  . LEU A 1 32  ? -17.94436 -44.53616 15.75863  1.000 24.23685 ? 32  LEU A CB  1 
ATOM   238  C CG  . LEU A 1 32  ? -17.27632 -43.18443 15.94397  1.000 19.91436 ? 32  LEU A CG  1 
ATOM   239  C CD1 . LEU A 1 32  ? -18.34817 -42.16277 16.16779  1.000 16.19759 ? 32  LEU A CD1 1 
ATOM   240  C CD2 . LEU A 1 32  ? -16.32737 -43.28833 17.13338  1.000 21.43103 ? 32  LEU A CD2 1 
ATOM   241  N N   . ASP A 1 33  ? -17.65759 -47.91983 15.97522  1.000 22.18731 ? 33  ASP A N   1 
ATOM   242  C CA  . ASP A 1 33  ? -18.31861 -49.22348 15.82888  1.000 25.98156 ? 33  ASP A CA  1 
ATOM   243  C C   . ASP A 1 33  ? -18.07191 -49.65832 14.38159  1.000 18.77786 ? 33  ASP A C   1 
ATOM   244  O O   . ASP A 1 33  ? -16.94139 -49.52727 13.89849  1.000 22.10943 ? 33  ASP A O   1 
ATOM   245  C CB  . ASP A 1 33  ? -19.77499 -49.10070 16.26162  1.000 22.74599 ? 33  ASP A CB  1 
ATOM   246  C CG  . ASP A 1 33  ? -19.91282 -48.66260 17.72162  1.000 23.77203 ? 33  ASP A CG  1 
ATOM   247  O OD1 . ASP A 1 33  ? -19.11137 -49.12379 18.56373  1.000 26.08533 ? 33  ASP A OD1 1 
ATOM   248  O OD2 . ASP A 1 33  ? -20.82375 -47.86785 18.03810  1.000 34.46721 ? 33  ASP A OD2 1 
ATOM   249  N N   . ASP A 1 34  ? -19.08002 -50.14158 13.65214  1.000 20.66182 ? 34  ASP A N   1 
ATOM   250  C CA  . ASP A 1 34  ? -18.88302 -50.58517 12.27955  1.000 24.43385 ? 34  ASP A CA  1 
ATOM   251  C C   . ASP A 1 34  ? -19.36180 -49.55932 11.25831  1.000 22.87534 ? 34  ASP A C   1 
ATOM   252  O O   . ASP A 1 34  ? -19.76772 -49.93552 10.15045  1.000 21.47384 ? 34  ASP A O   1 
ATOM   253  C CB  . ASP A 1 34  ? -19.58406 -51.92816 12.04707  1.000 25.30701 ? 34  ASP A CB  1 
ATOM   254  C CG  . ASP A 1 34  ? -21.08499 -51.86069 12.28496  1.000 30.58236 ? 34  ASP A CG  1 
ATOM   255  O OD1 . ASP A 1 34  ? -21.56595 -50.82739 12.77769  1.000 26.75274 ? 34  ASP A OD1 1 
ATOM   256  O OD2 . ASP A 1 34  ? -21.79576 -52.84744 11.98109  1.000 26.71806 ? 34  ASP A OD2 1 
ATOM   257  N N   . VAL A 1 35  ? -19.30888 -48.26489 11.58794  1.000 20.43963 ? 35  VAL A N   1 
ATOM   258  C CA  . VAL A 1 35  ? -19.74990 -47.21332 10.67267  1.000 20.87504 ? 35  VAL A CA  1 
ATOM   259  C C   . VAL A 1 35  ? -18.63833 -46.17651 10.51726  1.000 18.32978 ? 35  VAL A C   1 
ATOM   260  O O   . VAL A 1 35  ? -18.00694 -45.77403 11.50186  1.000 18.52529 ? 35  VAL A O   1 
ATOM   261  C CB  . VAL A 1 35  ? -21.05979 -46.54114 11.15145  1.000 17.66826 ? 35  VAL A CB  1 
ATOM   262  C CG1 . VAL A 1 35  ? -21.49867 -45.42498 10.17549  1.000 18.96398 ? 35  VAL A CG1 1 
ATOM   263  C CG2 . VAL A 1 35  ? -22.18371 -47.56619 11.29440  1.000 23.03257 ? 35  VAL A CG2 1 
ATOM   264  N N   . VAL A 1 36  ? -18.38671 -45.76230 9.27567   1.000 16.97723 ? 36  VAL A N   1 
ATOM   265  C CA  . VAL A 1 36  ? -17.48792 -44.64481 8.97254   1.000 21.25320 ? 36  VAL A CA  1 
ATOM   266  C C   . VAL A 1 36  ? -18.31824 -43.45642 8.51092   1.000 19.81680 ? 36  VAL A C   1 
ATOM   267  O O   . VAL A 1 36  ? -19.10023 -43.56906 7.55535   1.000 16.76737 ? 36  VAL A O   1 
ATOM   268  C CB  . VAL A 1 36  ? -16.44337 -45.02329 7.90911   1.000 18.55415 ? 36  VAL A CB  1 
ATOM   269  C CG1 . VAL A 1 36  ? -15.62924 -43.79053 7.47534   1.000 17.67877 ? 36  VAL A CG1 1 
ATOM   270  C CG2 . VAL A 1 36  ? -15.50193 -46.09068 8.47148   1.000 19.22814 ? 36  VAL A CG2 1 
ATOM   271  N N   . TYR A 1 37  ? -18.12493 -42.31476 9.17351   1.000 16.99974 ? 37  TYR A N   1 
ATOM   272  C CA  . TYR A 1 37  ? -18.84608 -41.06869 8.90394   1.000 16.37129 ? 37  TYR A CA  1 
ATOM   273  C C   . TYR A 1 37  ? -17.91523 -40.10399 8.18725   1.000 17.16376 ? 37  TYR A C   1 
ATOM   274  O O   . TYR A 1 37  ? -16.76866 -39.93315 8.59985   1.000 17.42058 ? 37  TYR A O   1 
ATOM   275  C CB  . TYR A 1 37  ? -19.33192 -40.42380 10.20507  1.000 15.79979 ? 37  TYR A CB  1 
ATOM   276  C CG  . TYR A 1 37  ? -20.20840 -41.31916 11.03868  1.000 16.83810 ? 37  TYR A CG  1 
ATOM   277  C CD1 . TYR A 1 37  ? -19.65439 -42.27247 11.89355  1.000 17.89813 ? 37  TYR A CD1 1 
ATOM   278  C CD2 . TYR A 1 37  ? -21.58876 -41.22672 10.96045  1.000 18.34621 ? 37  TYR A CD2 1 
ATOM   279  C CE1 . TYR A 1 37  ? -20.45893 -43.10021 12.65091  1.000 22.40004 ? 37  TYR A CE1 1 
ATOM   280  C CE2 . TYR A 1 37  ? -22.40299 -42.04004 11.71887  1.000 16.78785 ? 37  TYR A CE2 1 
ATOM   281  C CZ  . TYR A 1 37  ? -21.83024 -42.98292 12.55693  1.000 23.84162 ? 37  TYR A CZ  1 
ATOM   282  O OH  . TYR A 1 37  ? -22.63860 -43.80681 13.30174  1.000 22.77069 ? 37  TYR A OH  1 
ATOM   283  N N   . CYS A 1 38  ? -18.39237 -39.48169 7.11410   1.000 16.20406 ? 38  CYS A N   1 
ATOM   284  C CA  . CYS A 1 38  ? -17.55182 -38.53139 6.39364   1.000 14.05269 ? 38  CYS A CA  1 
ATOM   285  C C   . CYS A 1 38  ? -18.45355 -37.55845 5.63414   1.000 15.79254 ? 38  CYS A C   1 
ATOM   286  O O   . CYS A 1 38  ? -19.66757 -37.77747 5.52528   1.000 16.92146 ? 38  CYS A O   1 
ATOM   287  C CB  . CYS A 1 38  ? -16.57220 -39.25455 5.45216   1.000 16.26074 ? 38  CYS A CB  1 
ATOM   288  S SG  . CYS A 1 38  ? -17.35896 -39.95113 3.97662   1.000 18.02417 ? 38  CYS A SG  1 
ATOM   289  N N   . PRO A 1 39  ? -17.89731 -36.44572 5.13515   1.000 16.09617 ? 39  PRO A N   1 
ATOM   290  C CA  . PRO A 1 39  ? -18.71269 -35.50475 4.34901   1.000 14.38680 ? 39  PRO A CA  1 
ATOM   291  C C   . PRO A 1 39  ? -19.20164 -36.15191 3.06642   1.000 14.79647 ? 39  PRO A C   1 
ATOM   292  O O   . PRO A 1 39  ? -18.45698 -36.86293 2.38966   1.000 16.02495 ? 39  PRO A O   1 
ATOM   293  C CB  . PRO A 1 39  ? -17.74244 -34.36215 4.04070   1.000 14.09821 ? 39  PRO A CB  1 
ATOM   294  C CG  . PRO A 1 39  ? -16.75288 -34.43302 5.18914   1.000 13.60346 ? 39  PRO A CG  1 
ATOM   295  C CD  . PRO A 1 39  ? -16.54434 -35.91413 5.36232   1.000 16.47905 ? 39  PRO A CD  1 
ATOM   296  N N   . ARG A 1 40  ? -20.44284 -35.86555 2.71140   1.000 15.44978 ? 40  ARG A N   1 
ATOM   297  C CA  . ARG A 1 40  ? -20.94192 -36.48055 1.49076   1.000 14.87096 ? 40  ARG A CA  1 
ATOM   298  C C   . ARG A 1 40  ? -20.23353 -35.93938 0.25718   1.000 20.59835 ? 40  ARG A C   1 
ATOM   299  O O   . ARG A 1 40  ? -20.22792 -36.60243 -0.78513  1.000 16.52285 ? 40  ARG A O   1 
ATOM   300  C CB  . ARG A 1 40  ? -22.45204 -36.29360 1.37010   1.000 13.75071 ? 40  ARG A CB  1 
ATOM   301  C CG  . ARG A 1 40  ? -22.86347 -34.86547 1.14703   1.000 13.67640 ? 40  ARG A CG  1 
ATOM   302  C CD  . ARG A 1 40  ? -24.36855 -34.82356 1.06542   1.000 14.24854 ? 40  ARG A CD  1 
ATOM   303  N NE  . ARG A 1 40  ? -24.86200 -33.46562 0.91108   1.000 17.25374 ? 40  ARG A NE  1 
ATOM   304  C CZ  . ARG A 1 40  ? -26.12001 -33.16199 0.62731   1.000 16.08201 ? 40  ARG A CZ  1 
ATOM   305  N NH1 . ARG A 1 40  ? -27.03070 -34.10764 0.42613   1.000 18.30425 ? 40  ARG A NH1 1 
ATOM   306  N NH2 . ARG A 1 40  ? -26.47012 -31.87813 0.52475   1.000 17.02908 ? 40  ARG A NH2 1 
ATOM   307  N N   . HIS A 1 41  ? -19.59367 -34.78065 0.34129   1.000 15.62836 ? 41  HIS A N   1 
ATOM   308  C CA  . HIS A 1 41  ? -18.98280 -34.26393 -0.87466  1.000 21.68236 ? 41  HIS A CA  1 
ATOM   309  C C   . HIS A 1 41  ? -17.69987 -35.01078 -1.24214  1.000 21.12698 ? 41  HIS A C   1 
ATOM   310  O O   . HIS A 1 41  ? -17.05881 -34.65992 -2.23401  1.000 24.32597 ? 41  HIS A O   1 
ATOM   311  C CB  . HIS A 1 41  ? -18.77968 -32.72951 -0.79399  1.000 16.67132 ? 41  HIS A CB  1 
ATOM   312  C CG  . HIS A 1 41  ? -17.81315 -32.25562 0.24600   1.000 20.95179 ? 41  HIS A CG  1 
ATOM   313  N ND1 . HIS A 1 41  ? -16.49467 -32.65601 0.28780   1.000 31.32071 ? 41  HIS A ND1 1 
ATOM   314  C CD2 . HIS A 1 41  ? -17.95826 -31.33795 1.23231   1.000 17.93859 ? 41  HIS A CD2 1 
ATOM   315  C CE1 . HIS A 1 41  ? -15.88113 -32.03857 1.28448   1.000 28.70976 ? 41  HIS A CE1 1 
ATOM   316  N NE2 . HIS A 1 41  ? -16.74510 -31.22789 1.86910   1.000 23.22150 ? 41  HIS A NE2 1 
ATOM   317  N N   . VAL A 1 42  ? -17.36288 -36.07794 -0.50721  1.000 18.11528 ? 42  VAL A N   1 
ATOM   318  C CA  . VAL A 1 42  ? -16.32788 -36.98696 -0.97889  1.000 21.32476 ? 42  VAL A CA  1 
ATOM   319  C C   . VAL A 1 42  ? -16.68798 -37.57691 -2.33941  1.000 19.65635 ? 42  VAL A C   1 
ATOM   320  O O   . VAL A 1 42  ? -15.79595 -38.00781 -3.07462  1.000 22.59870 ? 42  VAL A O   1 
ATOM   321  C CB  . VAL A 1 42  ? -16.07934 -38.10932 0.04875   1.000 17.86518 ? 42  VAL A CB  1 
ATOM   322  C CG1 . VAL A 1 42  ? -17.24059 -39.09374 0.07748   1.000 21.61646 ? 42  VAL A CG1 1 
ATOM   323  C CG2 . VAL A 1 42  ? -14.74276 -38.83858 -0.23171  1.000 20.69930 ? 42  VAL A CG2 1 
ATOM   324  N N   . ILE A 1 43  ? -17.97787 -37.61365 -2.69670  1.000 17.78380 ? 43  ILE A N   1 
ATOM   325  C CA  . ILE A 1 43  ? -18.37512 -38.19813 -3.97712  1.000 18.69076 ? 43  ILE A CA  1 
ATOM   326  C C   . ILE A 1 43  ? -18.32938 -37.19212 -5.11580  1.000 18.66054 ? 43  ILE A C   1 
ATOM   327  O O   . ILE A 1 43  ? -18.65518 -37.54593 -6.26003  1.000 22.53484 ? 43  ILE A O   1 
ATOM   328  C CB  . ILE A 1 43  ? -19.78837 -38.82406 -3.91945  1.000 17.39459 ? 43  ILE A CB  1 
ATOM   329  C CG1 . ILE A 1 43  ? -20.86225 -37.73167 -3.85132  1.000 19.71067 ? 43  ILE A CG1 1 
ATOM   330  C CG2 . ILE A 1 43  ? -19.89489 -39.83346 -2.76718  1.000 19.68180 ? 43  ILE A CG2 1 
ATOM   331  C CD1 . ILE A 1 43  ? -22.31404 -38.28383 -3.77982  1.000 22.03391 ? 43  ILE A CD1 1 
ATOM   332  N N   . CYS A 1 44  ? -17.93562 -35.94900 -4.84774  1.000 22.43801 ? 44  CYS A N   1 
ATOM   333  C CA  . CYS A 1 44  ? -17.91610 -34.89235 -5.84859  1.000 22.06872 ? 44  CYS A CA  1 
ATOM   334  C C   . CYS A 1 44  ? -16.52843 -34.69774 -6.44457  1.000 34.08256 ? 44  CYS A C   1 
ATOM   335  O O   . CYS A 1 44  ? -15.51278 -34.82188 -5.75564  1.000 37.32581 ? 44  CYS A O   1 
ATOM   336  C CB  . CYS A 1 44  ? -18.36125 -33.57160 -5.23203  1.000 21.70312 ? 44  CYS A CB  1 
ATOM   337  S SG  . CYS A 1 44  ? -20.03428 -33.61669 -4.63930  1.000 23.24520 ? 44  CYS A SG  1 
ATOM   338  N N   . THR A 1 45  ? -16.50276 -34.36399 -7.73346  1.000 34.87783 ? 45  THR A N   1 
ATOM   339  C CA  . THR A 1 45  ? -15.31776 -33.76894 -8.33100  1.000 42.60794 ? 45  THR A CA  1 
ATOM   340  C C   . THR A 1 45  ? -15.26281 -32.28079 -7.98906  1.000 43.81513 ? 45  THR A C   1 
ATOM   341  O O   . THR A 1 45  ? -16.19021 -31.71920 -7.39780  1.000 52.59380 ? 45  THR A O   1 
ATOM   342  C CB  . THR A 1 45  ? -15.32354 -33.95570 -9.84414  1.000 35.43946 ? 45  THR A CB  1 
ATOM   343  O OG1 . THR A 1 45  ? -16.39769 -33.19434 -10.40733 1.000 50.58426 ? 45  THR A OG1 1 
ATOM   344  C CG2 . THR A 1 45  ? -15.51736 -35.42661 -10.19289 1.000 31.51277 ? 45  THR A CG2 1 
ATOM   345  N N   . SER A 1 46  ? -14.15992 -31.63215 -8.37414  1.000 52.85991 ? 46  SER A N   1 
ATOM   346  C CA  . SER A 1 46  ? -14.04283 -30.19362 -8.14257  1.000 51.61884 ? 46  SER A CA  1 
ATOM   347  C C   . SER A 1 46  ? -15.15147 -29.43083 -8.85897  1.000 58.11465 ? 46  SER A C   1 
ATOM   348  O O   . SER A 1 46  ? -15.67161 -28.43638 -8.33339  1.000 44.24696 ? 46  SER A O   1 
ATOM   349  C CB  . SER A 1 46  ? -12.66833 -29.69436 -8.59103  1.000 51.38535 ? 46  SER A CB  1 
ATOM   350  N N   . GLU A 1 47  ? -15.54412 -29.90238 -10.04974 1.000 41.76165 ? 47  GLU A N   1 
ATOM   351  C CA  . GLU A 1 47  ? -16.60232 -29.25781 -10.81996 1.000 43.30151 ? 47  GLU A CA  1 
ATOM   352  C C   . GLU A 1 47  ? -17.99261 -29.60535 -10.30166 1.000 42.40348 ? 47  GLU A C   1 
ATOM   353  O O   . GLU A 1 47  ? -18.92023 -28.80268 -10.45953 1.000 45.51459 ? 47  GLU A O   1 
ATOM   354  C CB  . GLU A 1 47  ? -16.49334 -29.64801 -12.29654 1.000 44.59377 ? 47  GLU A CB  1 
ATOM   355  N N   . ASP A 1 48  ? -18.16448 -30.79385 -9.70596  1.000 41.25826 ? 48  ASP A N   1 
ATOM   356  C CA  . ASP A 1 48  ? -19.45405 -31.14227 -9.11325  1.000 35.73251 ? 48  ASP A CA  1 
ATOM   357  C C   . ASP A 1 48  ? -19.85790 -30.15282 -8.02941  1.000 26.05561 ? 48  ASP A C   1 
ATOM   358  O O   . ASP A 1 48  ? -21.05329 -29.93807 -7.80787  1.000 29.68433 ? 48  ASP A O   1 
ATOM   359  C CB  . ASP A 1 48  ? -19.42517 -32.54714 -8.49903  1.000 29.46491 ? 48  ASP A CB  1 
ATOM   360  C CG  . ASP A 1 48  ? -19.31825 -33.65872 -9.53043  1.000 34.85530 ? 48  ASP A CG  1 
ATOM   361  O OD1 . ASP A 1 48  ? -19.95879 -33.57170 -10.60322 1.000 35.21075 ? 48  ASP A OD1 1 
ATOM   362  O OD2 . ASP A 1 48  ? -18.60602 -34.64314 -9.23739  1.000 37.03219 ? 48  ASP A OD2 1 
ATOM   363  N N   . MET A 1 49  ? -18.88118 -29.56313 -7.32779  1.000 35.38029 ? 49  MET A N   1 
ATOM   364  C CA  . MET A 1 49  ? -19.16347 -28.73740 -6.15778  1.000 25.52460 ? 49  MET A CA  1 
ATOM   365  C C   . MET A 1 49  ? -19.85893 -27.42586 -6.49618  1.000 20.88177 ? 49  MET A C   1 
ATOM   366  O O   . MET A 1 49  ? -20.38576 -26.78157 -5.58556  1.000 23.93876 ? 49  MET A O   1 
ATOM   367  C CB  . MET A 1 49  ? -17.87076 -28.44737 -5.39118  1.000 28.90733 ? 49  MET A CB  1 
ATOM   368  C CG  . MET A 1 49  ? -17.28879 -29.66510 -4.69724  1.000 32.34410 ? 49  MET A CG  1 
ATOM   369  S SD  . MET A 1 49  ? -18.44742 -30.37789 -3.50897  1.000 29.24368 ? 49  MET A SD  1 
ATOM   370  C CE  . MET A 1 49  ? -18.65373 -29.01750 -2.34833  1.000 26.29688 ? 49  MET A CE  1 
ATOM   371  N N   . LEU A 1 50  ? -19.89215 -27.02334 -7.76804  1.000 27.89198 ? 50  LEU A N   1 
ATOM   372  C CA  . LEU A 1 50  ? -20.61557 -25.80682 -8.13400  1.000 31.44852 ? 50  LEU A CA  1 
ATOM   373  C C   . LEU A 1 50  ? -22.12136 -25.95881 -7.92275  1.000 28.11883 ? 50  LEU A C   1 
ATOM   374  O O   . LEU A 1 50  ? -22.78292 -25.02806 -7.45542  1.000 26.23476 ? 50  LEU A O   1 
ATOM   375  C CB  . LEU A 1 50  ? -20.31279 -25.43194 -9.58573  1.000 40.32559 ? 50  LEU A CB  1 
ATOM   376  N N   . ASN A 1 51  ? -22.68727 -27.11157 -8.26875  1.000 24.15070 ? 51  ASN A N   1 
ATOM   377  C CA  . ASN A 1 51  ? -24.12386 -27.30286 -8.09555  1.000 28.15516 ? 51  ASN A CA  1 
ATOM   378  C C   . ASN A 1 51  ? -24.45786 -28.78760 -8.00162  1.000 21.55770 ? 51  ASN A C   1 
ATOM   379  O O   . ASN A 1 51  ? -25.16970 -29.31255 -8.86690  1.000 25.81340 ? 51  ASN A O   1 
ATOM   380  C CB  . ASN A 1 51  ? -24.88004 -26.66083 -9.26194  1.000 34.73159 ? 51  ASN A CB  1 
ATOM   381  C CG  . ASN A 1 51  ? -26.37843 -26.57557 -9.01929  1.000 40.16828 ? 51  ASN A CG  1 
ATOM   382  O OD1 . ASN A 1 51  ? -26.84219 -26.67034 -7.88450  1.000 39.67250 ? 51  ASN A OD1 1 
ATOM   383  N ND2 . ASN A 1 51  ? -27.14368 -26.38815 -10.09603 1.000 44.92598 ? 51  ASN A ND2 1 
ATOM   384  N N   . PRO A 1 52  ? -23.96471 -29.49796 -6.98772  1.000 22.83286 ? 52  PRO A N   1 
ATOM   385  C CA  . PRO A 1 52  ? -24.07188 -30.96382 -7.00166  1.000 19.05361 ? 52  PRO A CA  1 
ATOM   386  C C   . PRO A 1 52  ? -25.48628 -31.43510 -6.71163  1.000 20.77822 ? 52  PRO A C   1 
ATOM   387  O O   . PRO A 1 52  ? -26.18121 -30.89544 -5.84481  1.000 24.78993 ? 52  PRO A O   1 
ATOM   388  C CB  . PRO A 1 52  ? -23.10311 -31.40400 -5.89735  1.000 24.07451 ? 52  PRO A CB  1 
ATOM   389  C CG  . PRO A 1 52  ? -23.07502 -30.23513 -4.94260  1.000 30.47806 ? 52  PRO A CG  1 
ATOM   390  C CD  . PRO A 1 52  ? -23.29134 -28.99502 -5.77349  1.000 23.92874 ? 52  PRO A CD  1 
ATOM   391  N N   . ASN A 1 53  ? -25.91196 -32.45137 -7.46368  1.000 20.27850 ? 53  ASN A N   1 
ATOM   392  C CA  . ASN A 1 53  ? -27.09822 -33.23093 -7.12994  1.000 18.56909 ? 53  ASN A CA  1 
ATOM   393  C C   . ASN A 1 53  ? -26.61895 -34.46418 -6.36853  1.000 19.95824 ? 53  ASN A C   1 
ATOM   394  O O   . ASN A 1 53  ? -26.25740 -35.47732 -6.96288  1.000 17.53014 ? 53  ASN A O   1 
ATOM   395  C CB  . ASN A 1 53  ? -27.85847 -33.61569 -8.39229  1.000 19.03189 ? 53  ASN A CB  1 
ATOM   396  C CG  . ASN A 1 53  ? -29.21649 -34.17394 -8.09551  1.000 27.45846 ? 53  ASN A CG  1 
ATOM   397  O OD1 . ASN A 1 53  ? -29.37949 -34.99422 -7.19556  1.000 28.33940 ? 53  ASN A OD1 1 
ATOM   398  N ND2 . ASN A 1 53  ? -30.21582 -33.72829 -8.85301  1.000 32.02939 ? 53  ASN A ND2 1 
ATOM   399  N N   . TYR A 1 54  ? -26.58689 -34.36917 -5.03605  1.000 16.58376 ? 54  TYR A N   1 
ATOM   400  C CA  . TYR A 1 54  ? -25.94623 -35.42816 -4.26654  1.000 19.65492 ? 54  TYR A CA  1 
ATOM   401  C C   . TYR A 1 54  ? -26.65402 -36.76434 -4.45089  1.000 18.63127 ? 54  TYR A C   1 
ATOM   402  O O   . TYR A 1 54  ? -25.99872 -37.80765 -4.52675  1.000 18.52057 ? 54  TYR A O   1 
ATOM   403  C CB  . TYR A 1 54  ? -25.88070 -35.03746 -2.79684  1.000 16.13183 ? 54  TYR A CB  1 
ATOM   404  C CG  . TYR A 1 54  ? -24.77033 -34.04512 -2.52931  1.000 18.73467 ? 54  TYR A CG  1 
ATOM   405  C CD1 . TYR A 1 54  ? -23.45287 -34.46308 -2.47016  1.000 18.09224 ? 54  TYR A CD1 1 
ATOM   406  C CD2 . TYR A 1 54  ? -25.04485 -32.69903 -2.37113  1.000 16.64357 ? 54  TYR A CD2 1 
ATOM   407  C CE1 . TYR A 1 54  ? -22.43351 -33.56109 -2.21739  1.000 18.55176 ? 54  TYR A CE1 1 
ATOM   408  C CE2 . TYR A 1 54  ? -24.03069 -31.78562 -2.11959  1.000 20.94843 ? 54  TYR A CE2 1 
ATOM   409  C CZ  . TYR A 1 54  ? -22.72872 -32.23288 -2.05706  1.000 23.34263 ? 54  TYR A CZ  1 
ATOM   410  O OH  . TYR A 1 54  ? -21.70958 -31.34691 -1.82226  1.000 18.76905 ? 54  TYR A OH  1 
ATOM   411  N N   . GLU A 1 55  ? -27.98424 -36.74542 -4.56565  1.000 19.93762 ? 55  GLU A N   1 
ATOM   412  C CA  . GLU A 1 55  ? -28.72505 -37.99349 -4.75095  1.000 22.41906 ? 55  GLU A CA  1 
ATOM   413  C C   . GLU A 1 55  ? -28.32954 -38.67537 -6.05524  1.000 20.08737 ? 55  GLU A C   1 
ATOM   414  O O   . GLU A 1 55  ? -28.02123 -39.87737 -6.07856  1.000 18.83477 ? 55  GLU A O   1 
ATOM   415  C CB  . GLU A 1 55  ? -30.23294 -37.72244 -4.71321  1.000 24.51331 ? 55  GLU A CB  1 
ATOM   416  C CG  . GLU A 1 55  ? -30.76894 -37.33517 -3.33626  1.000 25.97891 ? 55  GLU A CG  1 
ATOM   417  C CD  . GLU A 1 55  ? -30.44168 -35.89181 -2.94832  1.000 35.34114 ? 55  GLU A CD  1 
ATOM   418  O OE1 . GLU A 1 55  ? -30.01015 -35.09994 -3.82593  1.000 33.98632 ? 55  GLU A OE1 1 
ATOM   419  O OE2 . GLU A 1 55  ? -30.61338 -35.55152 -1.75777  1.000 48.23100 ? 55  GLU A OE2 1 
ATOM   420  N N   . ASP A 1 56  ? -28.28728 -37.90988 -7.14488  1.000 20.82076 ? 56  ASP A N   1 
ATOM   421  C CA  . ASP A 1 56  ? -27.85931 -38.46509 -8.42789  1.000 22.19202 ? 56  ASP A CA  1 
ATOM   422  C C   . ASP A 1 56  ? -26.40655 -38.91769 -8.37893  1.000 20.66407 ? 56  ASP A C   1 
ATOM   423  O O   . ASP A 1 56  ? -26.06411 -39.98333 -8.89883  1.000 22.75831 ? 56  ASP A O   1 
ATOM   424  C CB  . ASP A 1 56  ? -28.03825 -37.43591 -9.54315  1.000 22.96794 ? 56  ASP A CB  1 
ATOM   425  C CG  . ASP A 1 56  ? -29.48909 -37.21521 -9.92744  1.000 27.95489 ? 56  ASP A CG  1 
ATOM   426  O OD1 . ASP A 1 56  ? -30.37791 -37.91368 -9.39596  1.000 25.28068 ? 56  ASP A OD1 1 
ATOM   427  O OD2 . ASP A 1 56  ? -29.73514 -36.32837 -10.77339 1.000 31.36723 ? 56  ASP A OD2 1 
ATOM   428  N N   . LEU A 1 57  ? -25.52995 -38.12772 -7.74156  1.000 20.38193 ? 57  LEU A N   1 
ATOM   429  C CA  . LEU A 1 57  ? -24.12151 -38.50046 -7.69782  1.000 29.25498 ? 57  LEU A CA  1 
ATOM   430  C C   . LEU A 1 57  ? -23.91182 -39.77553 -6.89249  1.000 20.27896 ? 57  LEU A C   1 
ATOM   431  O O   . LEU A 1 57  ? -23.09680 -40.62310 -7.26431  1.000 24.28614 ? 57  LEU A O   1 
ATOM   432  C CB  . LEU A 1 57  ? -23.29897 -37.35505 -7.11412  1.000 17.81069 ? 57  LEU A CB  1 
ATOM   433  C CG  . LEU A 1 57  ? -23.17549 -36.12730 -8.02090  1.000 21.63502 ? 57  LEU A CG  1 
ATOM   434  C CD1 . LEU A 1 57  ? -22.57324 -34.95868 -7.23810  1.000 21.49119 ? 57  LEU A CD1 1 
ATOM   435  C CD2 . LEU A 1 57  ? -22.31500 -36.43085 -9.25143  1.000 25.11499 ? 57  LEU A CD2 1 
ATOM   436  N N   . LEU A 1 58  ? -24.66268 -39.94011 -5.80394  1.000 17.12941 ? 58  LEU A N   1 
ATOM   437  C CA  . LEU A 1 58  ? -24.47598 -41.10650 -4.95661  1.000 18.82343 ? 58  LEU A CA  1 
ATOM   438  C C   . LEU A 1 58  ? -24.99163 -42.36981 -5.62974  1.000 23.94040 ? 58  LEU A C   1 
ATOM   439  O O   . LEU A 1 58  ? -24.46137 -43.46111 -5.38729  1.000 21.90870 ? 58  LEU A O   1 
ATOM   440  C CB  . LEU A 1 58  ? -25.17825 -40.90360 -3.61776  1.000 15.92100 ? 58  LEU A CB  1 
ATOM   441  C CG  . LEU A 1 58  ? -24.90350 -41.97031 -2.55967  1.000 18.93441 ? 58  LEU A CG  1 
ATOM   442  C CD1 . LEU A 1 58  ? -23.38583 -42.17458 -2.33605  1.000 24.52101 ? 58  LEU A CD1 1 
ATOM   443  C CD2 . LEU A 1 58  ? -25.57909 -41.56177 -1.26969  1.000 23.12859 ? 58  LEU A CD2 1 
ATOM   444  N N   . ILE A 1 59  ? -26.02800 -42.23844 -6.45999  1.000 23.50608 ? 59  ILE A N   1 
ATOM   445  C CA  . ILE A 1 59  ? -26.60044 -43.39842 -7.14196  1.000 27.91480 ? 59  ILE A CA  1 
ATOM   446  C C   . ILE A 1 59  ? -25.56754 -44.03831 -8.05532  1.000 22.66662 ? 59  ILE A C   1 
ATOM   447  O O   . ILE A 1 59  ? -25.54801 -45.26509 -8.22658  1.000 31.98419 ? 59  ILE A O   1 
ATOM   448  C CB  . ILE A 1 59  ? -27.87781 -42.98111 -7.89869  1.000 19.12187 ? 59  ILE A CB  1 
ATOM   449  C CG1 . ILE A 1 59  ? -29.04685 -42.84293 -6.92028  1.000 20.85642 ? 59  ILE A CG1 1 
ATOM   450  C CG2 . ILE A 1 59  ? -28.22929 -43.97322 -9.00713  1.000 26.21296 ? 59  ILE A CG2 1 
ATOM   451  C CD1 . ILE A 1 59  ? -30.22848 -42.09145 -7.46171  1.000 20.77225 ? 59  ILE A CD1 1 
ATOM   452  N N   . ARG A 1 60  ? -24.66477 -43.24005 -8.61032  1.000 23.14157 ? 60  ARG A N   1 
ATOM   453  C CA  . ARG A 1 60  ? -23.60246 -43.78457 -9.44456  1.000 27.54037 ? 60  ARG A CA  1 
ATOM   454  C C   . ARG A 1 60  ? -22.49370 -44.47505 -8.65371  1.000 31.84675 ? 60  ARG A C   1 
ATOM   455  O O   . ARG A 1 60  ? -21.55003 -44.97667 -9.27939  1.000 32.47170 ? 60  ARG A O   1 
ATOM   456  C CB  . ARG A 1 60  ? -23.01627 -42.67332 -10.30989 1.000 26.02597 ? 60  ARG A CB  1 
ATOM   457  C CG  . ARG A 1 60  ? -23.83083 -42.38347 -11.56213 1.000 47.84645 ? 60  ARG A CG  1 
ATOM   458  C CD  . ARG A 1 60  ? -23.99543 -40.89245 -11.79710 1.000 50.40690 ? 60  ARG A CD  1 
ATOM   459  N NE  . ARG A 1 60  ? -22.72699 -40.17365 -11.81518 1.000 43.49897 ? 60  ARG A NE  1 
ATOM   460  C CZ  . ARG A 1 60  ? -22.61179 -38.87727 -12.07097 1.000 62.06966 ? 60  ARG A CZ  1 
ATOM   461  N NH1 . ARG A 1 60  ? -23.67347 -38.12425 -12.32003 1.000 58.65099 ? 60  ARG A NH1 1 
ATOM   462  N NH2 . ARG A 1 60  ? -21.40269 -38.32291 -12.08150 1.000 45.30495 ? 60  ARG A NH2 1 
ATOM   463  N N   . LYS A 1 61  ? -22.56733 -44.51108 -7.32089  1.000 22.46412 ? 61  LYS A N   1 
ATOM   464  C CA  . LYS A 1 61  ? -21.55247 -45.13694 -6.48244  1.000 22.88502 ? 61  LYS A CA  1 
ATOM   465  C C   . LYS A 1 61  ? -22.08278 -46.43494 -5.89066  1.000 22.45291 ? 61  LYS A C   1 
ATOM   466  O O   . LYS A 1 61  ? -23.25864 -46.52866 -5.51751  1.000 28.15413 ? 61  LYS A O   1 
ATOM   467  C CB  . LYS A 1 61  ? -21.11974 -44.19982 -5.33672  1.000 21.30401 ? 61  LYS A CB  1 
ATOM   468  C CG  . LYS A 1 61  ? -20.60681 -42.83691 -5.78014  1.000 22.81902 ? 61  LYS A CG  1 
ATOM   469  C CD  . LYS A 1 61  ? -19.39652 -42.94895 -6.69185  1.000 23.94061 ? 61  LYS A CD  1 
ATOM   470  C CE  . LYS A 1 61  ? -18.93433 -41.57350 -7.13706  1.000 33.57749 ? 61  LYS A CE  1 
ATOM   471  N NZ  . LYS A 1 61  ? -17.68540 -41.64224 -7.94658  1.000 31.55574 ? 61  LYS A NZ  1 
ATOM   472  N N   . SER A 1 62  ? -21.21327 -47.43554 -5.80086  1.000 23.96227 ? 62  SER A N   1 
ATOM   473  C CA  . SER A 1 62  ? -21.51542 -48.66527 -5.08613  1.000 28.09228 ? 62  SER A CA  1 
ATOM   474  C C   . SER A 1 62  ? -20.56061 -48.79387 -3.90746  1.000 27.40547 ? 62  SER A C   1 
ATOM   475  O O   . SER A 1 62  ? -19.59655 -48.03743 -3.78421  1.000 29.78762 ? 62  SER A O   1 
ATOM   476  C CB  . SER A 1 62  ? -21.40839 -49.89223 -6.00359  1.000 28.11618 ? 62  SER A CB  1 
ATOM   477  O OG  . SER A 1 62  ? -22.33681 -49.81097 -7.07713  1.000 28.20439 ? 62  SER A OG  1 
ATOM   478  N N   . ASN A 1 63  ? -20.83589 -49.77951 -3.04535  1.000 26.42554 ? 63  ASN A N   1 
ATOM   479  C CA  . ASN A 1 63  ? -19.98307 -50.01120 -1.88303  1.000 22.40865 ? 63  ASN A CA  1 
ATOM   480  C C   . ASN A 1 63  ? -18.51288 -50.10459 -2.27053  1.000 23.60816 ? 63  ASN A C   1 
ATOM   481  O O   . ASN A 1 63  ? -17.64947 -49.54542 -1.58286  1.000 26.43942 ? 63  ASN A O   1 
ATOM   482  C CB  . ASN A 1 63  ? -20.41663 -51.28199 -1.14796  1.000 24.20182 ? 63  ASN A CB  1 
ATOM   483  C CG  . ASN A 1 63  ? -21.77417 -51.14642 -0.51081  1.000 33.48700 ? 63  ASN A CG  1 
ATOM   484  O OD1 . ASN A 1 63  ? -22.21591 -50.03970 -0.18500  1.000 25.55021 ? 63  ASN A OD1 1 
ATOM   485  N ND2 . ASN A 1 63  ? -22.45156 -52.27504 -0.32512  1.000 31.80972 ? 63  ASN A ND2 1 
ATOM   486  N N   . HIS A 1 64  ? -18.20232 -50.78917 -3.37548  1.000 25.59647 ? 64  HIS A N   1 
ATOM   487  C CA  . HIS A 1 64  ? -16.79494 -50.99051 -3.71397  1.000 28.51901 ? 64  HIS A CA  1 
ATOM   488  C C   . HIS A 1 64  ? -16.11596 -49.73617 -4.25407  1.000 24.72662 ? 64  HIS A C   1 
ATOM   489  O O   . HIS A 1 64  ? -14.89451 -49.74699 -4.43129  1.000 30.03848 ? 64  HIS A O   1 
ATOM   490  C CB  . HIS A 1 64  ? -16.64075 -52.13836 -4.72033  1.000 28.37748 ? 64  HIS A CB  1 
ATOM   491  C CG  . HIS A 1 64  ? -17.19906 -51.84085 -6.07666  1.000 27.65228 ? 64  HIS A CG  1 
ATOM   492  N ND1 . HIS A 1 64  ? -18.47507 -52.20012 -6.45131  1.000 28.01604 ? 64  HIS A ND1 1 
ATOM   493  C CD2 . HIS A 1 64  ? -16.65325 -51.21516 -7.14700  1.000 30.24185 ? 64  HIS A CD2 1 
ATOM   494  C CE1 . HIS A 1 64  ? -18.69026 -51.81344 -7.69666  1.000 29.76203 ? 64  HIS A CE1 1 
ATOM   495  N NE2 . HIS A 1 64  ? -17.60253 -51.20808 -8.13977  1.000 24.54988 ? 64  HIS A NE2 1 
ATOM   496  N N   . ASN A 1 65  ? -16.85845 -48.65799 -4.50581  1.000 26.91271 ? 65  ASN A N   1 
ATOM   497  C CA  . ASN A 1 65  ? -16.24575 -47.40929 -4.94117  1.000 28.78699 ? 65  ASN A CA  1 
ATOM   498  C C   . ASN A 1 65  ? -15.67786 -46.59454 -3.78465  1.000 32.22451 ? 65  ASN A C   1 
ATOM   499  O O   . ASN A 1 65  ? -14.98158 -45.60260 -4.02836  1.000 28.50084 ? 65  ASN A O   1 
ATOM   500  C CB  . ASN A 1 65  ? -17.26326 -46.56218 -5.69207  1.000 21.31490 ? 65  ASN A CB  1 
ATOM   501  C CG  . ASN A 1 65  ? -17.74823 -47.22495 -6.97795  1.000 32.05215 ? 65  ASN A CG  1 
ATOM   502  O OD1 . ASN A 1 65  ? -18.94813 -47.41921 -7.17319  1.000 34.09934 ? 65  ASN A OD1 1 
ATOM   503  N ND2 . ASN A 1 65  ? -16.80939 -47.57909 -7.85519  1.000 29.37560 ? 65  ASN A ND2 1 
ATOM   504  N N   . PHE A 1 66  ? -15.96639 -46.97534 -2.54474  1.000 23.60253 ? 66  PHE A N   1 
ATOM   505  C CA  . PHE A 1 66  ? -15.44844 -46.28869 -1.36723  1.000 28.10290 ? 66  PHE A CA  1 
ATOM   506  C C   . PHE A 1 66  ? -14.28404 -47.08507 -0.79675  1.000 27.41018 ? 66  PHE A C   1 
ATOM   507  O O   . PHE A 1 66  ? -14.46353 -48.22545 -0.35833  1.000 34.84052 ? 66  PHE A O   1 
ATOM   508  C CB  . PHE A 1 66  ? -16.54481 -46.11360 -0.31877  1.000 24.52527 ? 66  PHE A CB  1 
ATOM   509  C CG  . PHE A 1 66  ? -17.67757 -45.26359 -0.78670  1.000 26.40185 ? 66  PHE A CG  1 
ATOM   510  C CD1 . PHE A 1 66  ? -17.58429 -43.88294 -0.71890  1.000 23.17937 ? 66  PHE A CD1 1 
ATOM   511  C CD2 . PHE A 1 66  ? -18.82536 -45.83555 -1.31070  1.000 20.29699 ? 66  PHE A CD2 1 
ATOM   512  C CE1 . PHE A 1 66  ? -18.62010 -43.08424 -1.15168  1.000 22.87909 ? 66  PHE A CE1 1 
ATOM   513  C CE2 . PHE A 1 66  ? -19.88024 -45.04244 -1.75068  1.000 25.75586 ? 66  PHE A CE2 1 
ATOM   514  C CZ  . PHE A 1 66  ? -19.77977 -43.66132 -1.67435  1.000 25.11714 ? 66  PHE A CZ  1 
ATOM   515  N N   . LEU A 1 67  ? -13.09938 -46.48924 -0.81594  1.000 22.09991 ? 67  LEU A N   1 
ATOM   516  C CA  . LEU A 1 67  ? -11.90603 -47.08928 -0.23586  1.000 28.69724 ? 67  LEU A CA  1 
ATOM   517  C C   . LEU A 1 67  ? -11.64797 -46.45947 1.12458   1.000 30.36175 ? 67  LEU A C   1 
ATOM   518  O O   . LEU A 1 67  ? -11.40300 -45.24713 1.21080   1.000 28.34987 ? 67  LEU A O   1 
ATOM   519  C CB  . LEU A 1 67  ? -10.70079 -46.88308 -1.14567  1.000 25.77183 ? 67  LEU A CB  1 
ATOM   520  C CG  . LEU A 1 67  ? -10.79100 -47.53269 -2.52092  1.000 39.00083 ? 67  LEU A CG  1 
ATOM   521  C CD1 . LEU A 1 67  ? -9.53040  -47.22140 -3.29208  1.000 37.93360 ? 67  LEU A CD1 1 
ATOM   522  C CD2 . LEU A 1 67  ? -11.00290 -49.03360 -2.39001  1.000 38.98059 ? 67  LEU A CD2 1 
ATOM   523  N N   . VAL A 1 68  ? -11.67393 -47.27876 2.17319   1.000 21.30982 ? 68  VAL A N   1 
ATOM   524  C CA  . VAL A 1 68  ? -11.47906 -46.80103 3.54750   1.000 19.07395 ? 68  VAL A CA  1 
ATOM   525  C C   . VAL A 1 68  ? -10.27141 -47.49548 4.15122   1.000 25.10842 ? 68  VAL A C   1 
ATOM   526  O O   . VAL A 1 68  ? -10.23710 -48.72936 4.24218   1.000 27.34156 ? 68  VAL A O   1 
ATOM   527  C CB  . VAL A 1 68  ? -12.72104 -47.02786 4.41647   1.000 26.45060 ? 68  VAL A CB  1 
ATOM   528  C CG1 . VAL A 1 68  ? -12.46914 -46.50905 5.83849   1.000 20.87236 ? 68  VAL A CG1 1 
ATOM   529  C CG2 . VAL A 1 68  ? -13.92479 -46.34005 3.78751   1.000 29.25651 ? 68  VAL A CG2 1 
ATOM   530  N N   . GLN A 1 69  ? -9.31213  -46.69559 4.61234   1.000 24.99997 ? 69  GLN A N   1 
ATOM   531  C CA  . GLN A 1 69  ? -8.03298  -47.16171 5.12322   1.000 33.45268 ? 69  GLN A CA  1 
ATOM   532  C C   . GLN A 1 69  ? -7.83083  -46.56419 6.50820   1.000 34.29978 ? 69  GLN A C   1 
ATOM   533  O O   . GLN A 1 69  ? -7.84850  -45.33893 6.66653   1.000 26.92098 ? 69  GLN A O   1 
ATOM   534  C CB  . GLN A 1 69  ? -6.90344  -46.73661 4.18204   1.000 29.13316 ? 69  GLN A CB  1 
ATOM   535  C CG  . GLN A 1 69  ? -5.71490  -47.65707 4.12013   1.000 44.86099 ? 69  GLN A CG  1 
ATOM   536  C CD  . GLN A 1 69  ? -4.67377  -47.15204 3.14239   1.000 47.81828 ? 69  GLN A CD  1 
ATOM   537  O OE1 . GLN A 1 69  ? -4.99022  -46.40575 2.21503   1.000 48.26009 ? 69  GLN A OE1 1 
ATOM   538  N NE2 . GLN A 1 69  ? -3.42395  -47.54410 3.35089   1.000 68.38859 ? 69  GLN A NE2 1 
ATOM   539  N N   . ALA A 1 70  ? -7.65478  -47.42089 7.50666   1.000 32.77179 ? 70  ALA A N   1 
ATOM   540  C CA  . ALA A 1 70  ? -7.33008  -46.98578 8.86166   1.000 31.05487 ? 70  ALA A CA  1 
ATOM   541  C C   . ALA A 1 70  ? -5.84196  -47.25783 9.05570   1.000 51.84176 ? 70  ALA A C   1 
ATOM   542  O O   . ALA A 1 70  ? -5.43795  -48.35845 9.43063   1.000 50.15909 ? 70  ALA A O   1 
ATOM   543  C CB  . ALA A 1 70  ? -8.19009  -47.71184 9.88865   1.000 36.80715 ? 70  ALA A CB  1 
ATOM   544  N N   . GLY A 1 71  ? -5.02235  -46.24652 8.79121   1.000 46.29589 ? 71  GLY A N   1 
ATOM   545  C CA  . GLY A 1 71  ? -3.59095  -46.48325 8.72162   1.000 35.58112 ? 71  GLY A CA  1 
ATOM   546  C C   . GLY A 1 71  ? -3.31884  -47.49784 7.62957   1.000 48.27579 ? 71  GLY A C   1 
ATOM   547  O O   . GLY A 1 71  ? -3.68406  -47.29979 6.46686   1.000 53.99105 ? 71  GLY A O   1 
ATOM   548  N N   . ASN A 1 72  ? -2.69698  -48.62014 7.99331   1.000 57.37760 ? 72  ASN A N   1 
ATOM   549  C CA  . ASN A 1 72  ? -2.44487  -49.67590 7.02031   1.000 51.64802 ? 72  ASN A CA  1 
ATOM   550  C C   . ASN A 1 72  ? -3.63530  -50.61062 6.84352   1.000 56.33522 ? 72  ASN A C   1 
ATOM   551  O O   . ASN A 1 72  ? -3.71765  -51.29811 5.82033   1.000 61.13058 ? 72  ASN A O   1 
ATOM   552  C CB  . ASN A 1 72  ? -1.21155  -50.48730 7.42920   1.000 60.79537 ? 72  ASN A CB  1 
ATOM   553  N N   . VAL A 1 73  ? -4.55241  -50.65609 7.80870   1.000 54.12341 ? 73  VAL A N   1 
ATOM   554  C CA  . VAL A 1 73  ? -5.69469  -51.56056 7.72255   1.000 43.82902 ? 73  VAL A CA  1 
ATOM   555  C C   . VAL A 1 73  ? -6.69344  -51.01210 6.71017   1.000 57.34111 ? 73  VAL A C   1 
ATOM   556  O O   . VAL A 1 73  ? -7.22930  -49.91000 6.87487   1.000 42.47462 ? 73  VAL A O   1 
ATOM   557  C CB  . VAL A 1 73  ? -6.34924  -51.75187 9.09647   1.000 43.09322 ? 73  VAL A CB  1 
ATOM   558  N N   . GLN A 1 74  ? -6.94455  -51.77786 5.65380   1.000 57.02278 ? 74  GLN A N   1 
ATOM   559  C CA  . GLN A 1 74  ? -8.00192  -51.46081 4.70583   1.000 46.72288 ? 74  GLN A CA  1 
ATOM   560  C C   . GLN A 1 74  ? -9.31494  -52.04634 5.21044   1.000 45.41043 ? 74  GLN A C   1 
ATOM   561  O O   . GLN A 1 74  ? -9.36072  -53.20326 5.64120   1.000 46.96456 ? 74  GLN A O   1 
ATOM   562  C CB  . GLN A 1 74  ? -7.66290  -52.00427 3.31897   1.000 45.54027 ? 74  GLN A CB  1 
ATOM   563  C CG  . GLN A 1 74  ? -6.76105  -51.09200 2.50435   1.000 48.27836 ? 74  GLN A CG  1 
ATOM   564  C CD  . GLN A 1 74  ? -7.54554  -50.11782 1.64248   1.000 57.93730 ? 74  GLN A CD  1 
ATOM   565  O OE1 . GLN A 1 74  ? -8.71570  -50.34848 1.33153   1.000 62.35388 ? 74  GLN A OE1 1 
ATOM   566  N NE2 . GLN A 1 74  ? -6.90290  -49.02493 1.24736   1.000 50.09070 ? 74  GLN A NE2 1 
ATOM   567  N N   . LEU A 1 75  ? -10.37330 -51.24191 5.17638   1.000 25.99058 ? 75  LEU A N   1 
ATOM   568  C CA  . LEU A 1 75  ? -11.68624 -51.67613 5.63213   1.000 33.34404 ? 75  LEU A CA  1 
ATOM   569  C C   . LEU A 1 75  ? -12.53893 -52.04558 4.43082   1.000 29.16225 ? 75  LEU A C   1 
ATOM   570  O O   . LEU A 1 75  ? -12.36665 -51.50056 3.33792   1.000 41.43029 ? 75  LEU A O   1 
ATOM   571  C CB  . LEU A 1 75  ? -12.39827 -50.58701 6.43920   1.000 34.03756 ? 75  LEU A CB  1 
ATOM   572  C CG  . LEU A 1 75  ? -11.64082 -49.91295 7.58334   1.000 32.78862 ? 75  LEU A CG  1 
ATOM   573  C CD1 . LEU A 1 75  ? -12.57367 -48.99229 8.34245   1.000 24.48601 ? 75  LEU A CD1 1 
ATOM   574  C CD2 . LEU A 1 75  ? -11.00644 -50.93600 8.51186   1.000 37.17558 ? 75  LEU A CD2 1 
ATOM   575  N N   . ARG A 1 76  ? -13.46393 -52.97489 4.64287   1.000 30.70052 ? 76  ARG A N   1 
ATOM   576  C CA  . ARG A 1 76  ? -14.35492 -53.44120 3.59079   1.000 30.66101 ? 76  ARG A CA  1 
ATOM   577  C C   . ARG A 1 76  ? -15.71262 -52.77800 3.77729   1.000 29.96937 ? 76  ARG A C   1 
ATOM   578  O O   . ARG A 1 76  ? -16.36690 -52.98084 4.80510   1.000 28.47982 ? 76  ARG A O   1 
ATOM   579  C CB  . ARG A 1 76  ? -14.47865 -54.96451 3.62042   1.000 37.23624 ? 76  ARG A CB  1 
ATOM   580  C CG  . ARG A 1 76  ? -15.35697 -55.54383 2.52208   1.000 46.33814 ? 76  ARG A CG  1 
ATOM   581  C CD  . ARG A 1 76  ? -15.47503 -57.06147 2.66669   1.000 50.69587 ? 76  ARG A CD  1 
ATOM   582  N NE  . ARG A 1 76  ? -14.17125 -57.71722 2.65585   1.000 48.92523 ? 76  ARG A NE  1 
ATOM   583  C CZ  . ARG A 1 76  ? -13.55195 -58.12821 1.55753   1.000 40.47961 ? 76  ARG A CZ  1 
ATOM   584  N NH1 . ARG A 1 76  ? -14.10006 -57.98208 0.36081   1.000 28.40046 ? 76  ARG A NH1 1 
ATOM   585  N NH2 . ARG A 1 76  ? -12.35070 -58.69211 1.66172   1.000 36.16950 ? 76  ARG A NH2 1 
ATOM   586  N N   . VAL A 1 77  ? -16.12624 -51.98538 2.78902   1.000 31.60275 ? 77  VAL A N   1 
ATOM   587  C CA  . VAL A 1 77  ? -17.39618 -51.26619 2.84241   1.000 26.83224 ? 77  VAL A CA  1 
ATOM   588  C C   . VAL A 1 77  ? -18.52087 -52.18977 2.38246   1.000 27.80481 ? 77  VAL A C   1 
ATOM   589  O O   . VAL A 1 77  ? -18.50283 -52.69674 1.25545   1.000 31.98389 ? 77  VAL A O   1 
ATOM   590  C CB  . VAL A 1 77  ? -17.34126 -49.99308 1.98475   1.000 34.50810 ? 77  VAL A CB  1 
ATOM   591  C CG1 . VAL A 1 77  ? -18.71149 -49.32200 1.94978   1.000 24.91157 ? 77  VAL A CG1 1 
ATOM   592  C CG2 . VAL A 1 77  ? -16.28601 -49.02474 2.52124   1.000 30.00332 ? 77  VAL A CG2 1 
ATOM   593  N N   . ILE A 1 78  ? -19.52342 -52.38580 3.23844   1.000 29.12652 ? 78  ILE A N   1 
ATOM   594  C CA  . ILE A 1 78  ? -20.60743 -53.31765 2.95799   1.000 24.65625 ? 78  ILE A CA  1 
ATOM   595  C C   . ILE A 1 78  ? -21.97267 -52.64420 2.90804   1.000 32.53380 ? 78  ILE A C   1 
ATOM   596  O O   . ILE A 1 78  ? -22.97685 -53.32016 2.66946   1.000 30.41929 ? 78  ILE A O   1 
ATOM   597  C CB  . ILE A 1 78  ? -20.60912 -54.49026 3.96057   1.000 24.52922 ? 78  ILE A CB  1 
ATOM   598  C CG1 . ILE A 1 78  ? -20.89062 -53.99828 5.37954   1.000 30.11941 ? 78  ILE A CG1 1 
ATOM   599  C CG2 . ILE A 1 78  ? -19.25606 -55.19091 3.93980   1.000 25.73518 ? 78  ILE A CG2 1 
ATOM   600  C CD1 . ILE A 1 78  ? -20.93299 -55.10741 6.41511   1.000 37.46706 ? 78  ILE A CD1 1 
ATOM   601  N N   . GLY A 1 79  ? -22.04019 -51.33364 3.10992   1.000 24.29043 ? 79  GLY A N   1 
ATOM   602  C CA  . GLY A 1 79  ? -23.27266 -50.59429 2.92625   1.000 28.92724 ? 79  GLY A CA  1 
ATOM   603  C C   . GLY A 1 79  ? -22.94681 -49.12207 2.88405   1.000 22.40957 ? 79  GLY A C   1 
ATOM   604  O O   . GLY A 1 79  ? -21.89751 -48.68772 3.36361   1.000 22.31502 ? 79  GLY A O   1 
ATOM   605  N N   . HIS A 1 80  ? -23.83988 -48.35867 2.28072   1.000 22.05659 ? 80  HIS A N   1 
ATOM   606  C CA  . HIS A 1 80  ? -23.63838 -46.91735 2.29279   1.000 23.30319 ? 80  HIS A CA  1 
ATOM   607  C C   . HIS A 1 80  ? -24.98092 -46.21653 2.35726   1.000 27.26252 ? 80  HIS A C   1 
ATOM   608  O O   . HIS A 1 80  ? -25.97512 -46.68327 1.79345   1.000 25.31923 ? 80  HIS A O   1 
ATOM   609  C CB  . HIS A 1 80  ? -22.83392 -46.43005 1.08497   1.000 19.08368 ? 80  HIS A CB  1 
ATOM   610  C CG  . HIS A 1 80  ? -23.50447 -46.66302 -0.22872  1.000 21.20125 ? 80  HIS A CG  1 
ATOM   611  N ND1 . HIS A 1 80  ? -23.46597 -47.87689 -0.87875  1.000 25.97472 ? 80  HIS A ND1 1 
ATOM   612  C CD2 . HIS A 1 80  ? -24.22753 -45.83258 -1.01543  1.000 19.73189 ? 80  HIS A CD2 1 
ATOM   613  C CE1 . HIS A 1 80  ? -24.14835 -47.78504 -2.00718  1.000 25.22117 ? 80  HIS A CE1 1 
ATOM   614  N NE2 . HIS A 1 80  ? -24.61396 -46.55340 -2.11691  1.000 23.68385 ? 80  HIS A NE2 1 
ATOM   615  N N   . SER A 1 81  ? -25.00937 -45.09771 3.06608   1.000 20.19817 ? 81  SER A N   1 
ATOM   616  C CA  A SER A 1 81  ? -26.24650 -44.35937 3.25319   0.500 19.87375 ? 81  SER A CA  1 
ATOM   617  C CA  B SER A 1 81  ? -26.24521 -44.35589 3.23000   0.500 19.86892 ? 81  SER A CA  1 
ATOM   618  C C   . SER A 1 81  ? -25.90807 -42.89348 3.45247   1.000 22.25321 ? 81  SER A C   1 
ATOM   619  O O   . SER A 1 81  ? -24.95691 -42.57108 4.16275   1.000 24.39782 ? 81  SER A O   1 
ATOM   620  C CB  A SER A 1 81  ? -27.02879 -44.88517 4.45699   0.500 24.26973 ? 81  SER A CB  1 
ATOM   621  C CB  B SER A 1 81  ? -27.07253 -44.89237 4.39943   0.500 24.34638 ? 81  SER A CB  1 
ATOM   622  O OG  A SER A 1 81  ? -28.19680 -44.12211 4.68422   0.500 28.83139 ? 81  SER A OG  1 
ATOM   623  O OG  B SER A 1 81  ? -26.48400 -44.58329 5.65000   0.500 28.79950 ? 81  SER A OG  1 
ATOM   624  N N   . MET A 1 82  ? -26.68563 -42.02544 2.83124   1.000 17.65167 ? 82  MET A N   1 
ATOM   625  C CA  . MET A 1 82  ? -26.53799 -40.59387 3.00913   1.000 17.72137 ? 82  MET A CA  1 
ATOM   626  C C   . MET A 1 82  ? -27.54377 -40.12412 4.04459   1.000 19.21548 ? 82  MET A C   1 
ATOM   627  O O   . MET A 1 82  ? -28.73014 -40.46233 3.96734   1.000 19.62620 ? 82  MET A O   1 
ATOM   628  C CB  . MET A 1 82  ? -26.74423 -39.86288 1.68849   1.000 18.77564 ? 82  MET A CB  1 
ATOM   629  C CG  . MET A 1 82  ? -26.59276 -38.35736 1.79214   1.000 21.48658 ? 82  MET A CG  1 
ATOM   630  S SD  . MET A 1 82  ? -26.43913 -37.61891 0.15457   1.000 20.06466 ? 82  MET A SD  1 
ATOM   631  C CE  . MET A 1 82  ? -28.00548 -38.03988 -0.60528  1.000 21.22879 ? 82  MET A CE  1 
ATOM   632  N N   . GLN A 1 83  ? -27.05845 -39.39938 5.04902   1.000 17.09350 ? 83  GLN A N   1 
ATOM   633  C CA  . GLN A 1 83  ? -27.91532 -38.80578 6.06513   1.000 18.40410 ? 83  GLN A CA  1 
ATOM   634  C C   . GLN A 1 83  ? -27.61992 -37.31773 6.05448   1.000 17.89986 ? 83  GLN A C   1 
ATOM   635  O O   . GLN A 1 83  ? -26.52450 -36.90612 6.45020   1.000 17.63041 ? 83  GLN A O   1 
ATOM   636  C CB  . GLN A 1 83  ? -27.66279 -39.40016 7.44729   1.000 16.09181 ? 83  GLN A CB  1 
ATOM   637  C CG  . GLN A 1 83  ? -28.41504 -38.68060 8.53187   1.000 17.50897 ? 83  GLN A CG  1 
ATOM   638  C CD  . GLN A 1 83  ? -28.22205 -39.30587 9.90367   1.000 16.88485 ? 83  GLN A CD  1 
ATOM   639  O OE1 . GLN A 1 83  ? -27.27623 -40.06774 10.13318  1.000 20.16808 ? 83  GLN A OE1 1 
ATOM   640  N NE2 . GLN A 1 83  ? -29.14612 -39.01245 10.81420  1.000 22.08733 ? 83  GLN A NE2 1 
ATOM   641  N N   . ASN A 1 84  ? -28.57194 -36.52583 5.57378   1.000 16.36573 ? 84  ASN A N   1 
ATOM   642  C CA  . ASN A 1 84  ? -28.32702 -35.10196 5.40538   1.000 12.07104 ? 84  ASN A CA  1 
ATOM   643  C C   . ASN A 1 84  ? -27.02580 -34.88868 4.62872   1.000 14.11221 ? 84  ASN A C   1 
ATOM   644  O O   . ASN A 1 84  ? -26.88919 -35.36479 3.49481   1.000 16.08682 ? 84  ASN A O   1 
ATOM   645  C CB  . ASN A 1 84  ? -28.34690 -34.43039 6.78484   1.000 17.52408 ? 84  ASN A CB  1 
ATOM   646  C CG  . ASN A 1 84  ? -29.67667 -34.62774 7.49324   1.000 18.26728 ? 84  ASN A CG  1 
ATOM   647  O OD1 . ASN A 1 84  ? -30.73819 -34.39044 6.90139   1.000 20.93847 ? 84  ASN A OD1 1 
ATOM   648  N ND2 . ASN A 1 84  ? -29.63997 -35.12527 8.72589   1.000 21.38732 ? 84  ASN A ND2 1 
ATOM   649  N N   . CYS A 1 85  ? -26.05821 -34.17635 5.20530   1.000 13.24942 ? 85  CYS A N   1 
ATOM   650  C CA  . CYS A 1 85  ? -24.82930 -33.91386 4.47295   1.000 14.68544 ? 85  CYS A CA  1 
ATOM   651  C C   . CYS A 1 85  ? -23.68875 -34.87311 4.82745   1.000 15.69577 ? 85  CYS A C   1 
ATOM   652  O O   . CYS A 1 85  ? -22.56102 -34.65898 4.36338   1.000 14.90802 ? 85  CYS A O   1 
ATOM   653  C CB  . CYS A 1 85  ? -24.40204 -32.45938 4.67289   1.000 15.28364 ? 85  CYS A CB  1 
ATOM   654  S SG  . CYS A 1 85  ? -25.58232 -31.26759 3.98153   1.000 16.48875 ? 85  CYS A SG  1 
ATOM   655  N N   . VAL A 1 86  ? -23.94861 -35.94832 5.58988   1.000 14.76789 ? 86  VAL A N   1 
ATOM   656  C CA  . VAL A 1 86  ? -22.90303 -36.93476 5.85740   1.000 14.14601 ? 86  VAL A CA  1 
ATOM   657  C C   . VAL A 1 86  ? -23.20416 -38.24070 5.12663   1.000 16.90817 ? 86  VAL A C   1 
ATOM   658  O O   . VAL A 1 86  ? -24.35755 -38.62971 4.89289   1.000 19.21472 ? 86  VAL A O   1 
ATOM   659  C CB  . VAL A 1 86  ? -22.66665 -37.20670 7.35595   1.000 18.70629 ? 86  VAL A CB  1 
ATOM   660  C CG1 . VAL A 1 86  ? -22.14174 -35.94303 8.03752   1.000 22.52641 ? 86  VAL A CG1 1 
ATOM   661  C CG2 . VAL A 1 86  ? -23.90524 -37.74741 8.02701   1.000 25.59085 ? 86  VAL A CG2 1 
ATOM   662  N N   . LEU A 1 87  ? -22.13349 -38.90744 4.74566   1.000 15.61159 ? 87  LEU A N   1 
ATOM   663  C CA  . LEU A 1 87  ? -22.18431 -40.28755 4.28529   1.000 20.17790 ? 87  LEU A CA  1 
ATOM   664  C C   . LEU A 1 87  ? -21.83200 -41.22352 5.43500   1.000 19.26893 ? 87  LEU A C   1 
ATOM   665  O O   . LEU A 1 87  ? -20.89418 -40.96360 6.19181   1.000 18.67091 ? 87  LEU A O   1 
ATOM   666  C CB  . LEU A 1 87  ? -21.19837 -40.48866 3.13961   1.000 20.11290 ? 87  LEU A CB  1 
ATOM   667  C CG  . LEU A 1 87  ? -21.63137 -41.11343 1.82651   1.000 42.23830 ? 87  LEU A CG  1 
ATOM   668  C CD1 . LEU A 1 87  ? -22.80441 -40.34328 1.26124   1.000 33.71468 ? 87  LEU A CD1 1 
ATOM   669  C CD2 . LEU A 1 87  ? -20.43717 -41.03604 0.90317   1.000 25.26305 ? 87  LEU A CD2 1 
ATOM   670  N N   . LYS A 1 88  ? -22.59562 -42.30221 5.56922   1.000 17.87843 ? 88  LYS A N   1 
ATOM   671  C CA  . LYS A 1 88  ? -22.38015 -43.34672 6.55824   1.000 16.36944 ? 88  LYS A CA  1 
ATOM   672  C C   . LYS A 1 88  ? -22.02137 -44.60673 5.78933   1.000 24.73084 ? 88  LYS A C   1 
ATOM   673  O O   . LYS A 1 88  ? -22.84999 -45.13961 5.03630   1.000 26.71851 ? 88  LYS A O   1 
ATOM   674  C CB  . LYS A 1 88  ? -23.62090 -43.55530 7.42915   1.000 21.02101 ? 88  LYS A CB  1 
ATOM   675  C CG  . LYS A 1 88  ? -23.97795 -42.33836 8.28555   1.000 24.25600 ? 88  LYS A CG  1 
ATOM   676  C CD  . LYS A 1 88  ? -25.06871 -42.67544 9.30194   1.000 19.97601 ? 88  LYS A CD  1 
ATOM   677  C CE  . LYS A 1 88  ? -26.38023 -42.91609 8.61092   1.000 28.56122 ? 88  LYS A CE  1 
ATOM   678  N NZ  . LYS A 1 88  ? -27.49779 -42.79129 9.57734   1.000 29.60899 ? 88  LYS A NZ  1 
ATOM   679  N N   . LEU A 1 89  ? -20.77607 -45.04444 5.92677   1.000 20.59293 ? 89  LEU A N   1 
ATOM   680  C CA  . LEU A 1 89  ? -20.28742 -46.23861 5.24824   1.000 16.72553 ? 89  LEU A CA  1 
ATOM   681  C C   . LEU A 1 89  ? -20.23952 -47.37842 6.25234   1.000 17.96680 ? 89  LEU A C   1 
ATOM   682  O O   . LEU A 1 89  ? -19.45791 -47.34106 7.21059   1.000 19.90542 ? 89  LEU A O   1 
ATOM   683  C CB  . LEU A 1 89  ? -18.91420 -45.99257 4.64133   1.000 18.00737 ? 89  LEU A CB  1 
ATOM   684  C CG  . LEU A 1 89  ? -18.85120 -44.79172 3.70437   1.000 19.61937 ? 89  LEU A CG  1 
ATOM   685  C CD1 . LEU A 1 89  ? -17.42536 -44.56847 3.25809   1.000 22.95465 ? 89  LEU A CD1 1 
ATOM   686  C CD2 . LEU A 1 89  ? -19.79369 -44.93833 2.50678   1.000 20.88447 ? 89  LEU A CD2 1 
ATOM   687  N N   . LYS A 1 90  ? -21.09214 -48.37821 6.05270   1.000 24.71768 ? 90  LYS A N   1 
ATOM   688  C CA  A LYS A 1 90  ? -21.06086 -49.56674 6.88987   0.500 22.35023 ? 90  LYS A CA  1 
ATOM   689  C CA  B LYS A 1 90  ? -21.05293 -49.56089 6.89675   0.500 22.32710 ? 90  LYS A CA  1 
ATOM   690  C C   . LYS A 1 90  ? -19.86443 -50.42098 6.48744   1.000 25.46047 ? 90  LYS A C   1 
ATOM   691  O O   . LYS A 1 90  ? -19.68443 -50.72777 5.30779   1.000 26.48577 ? 90  LYS A O   1 
ATOM   692  C CB  A LYS A 1 90  ? -22.36811 -50.35192 6.74860   0.500 23.37713 ? 90  LYS A CB  1 
ATOM   693  C CB  B LYS A 1 90  ? -22.35796 -50.35153 6.78873   0.500 23.40362 ? 90  LYS A CB  1 
ATOM   694  C CG  A LYS A 1 90  ? -22.41539 -51.64212 7.54653   0.500 29.60288 ? 90  LYS A CG  1 
ATOM   695  C CG  B LYS A 1 90  ? -22.46089 -51.49597 7.78421   0.500 27.28875 ? 90  LYS A CG  1 
ATOM   696  C CD  A LYS A 1 90  ? -22.44663 -51.38955 9.03507   0.500 27.47511 ? 90  LYS A CD  1 
ATOM   697  C CD  B LYS A 1 90  ? -23.69119 -52.34146 7.51246   0.500 31.43195 ? 90  LYS A CD  1 
ATOM   698  C CE  A LYS A 1 90  ? -23.80166 -50.89031 9.49163   0.500 32.62967 ? 90  LYS A CE  1 
ATOM   699  C CE  B LYS A 1 90  ? -23.74180 -53.56320 8.41175   0.500 29.09970 ? 90  LYS A CE  1 
ATOM   700  N NZ  A LYS A 1 90  ? -23.83488 -50.71100 10.97571  0.500 33.83580 ? 90  LYS A NZ  1 
ATOM   701  N NZ  B LYS A 1 90  ? -25.01037 -54.32077 8.20847   0.500 42.15682 ? 90  LYS A NZ  1 
ATOM   702  N N   . VAL A 1 91  ? -19.03070 -50.77480 7.46187   1.000 23.07387 ? 91  VAL A N   1 
ATOM   703  C CA  . VAL A 1 91  ? -17.85528 -51.59902 7.21277   1.000 27.03736 ? 91  VAL A CA  1 
ATOM   704  C C   . VAL A 1 91  ? -18.01986 -52.90637 7.97662   1.000 21.21044 ? 91  VAL A C   1 
ATOM   705  O O   . VAL A 1 91  ? -18.85100 -53.02310 8.88224   1.000 30.58398 ? 91  VAL A O   1 
ATOM   706  C CB  . VAL A 1 91  ? -16.53992 -50.88946 7.59704   1.000 22.13092 ? 91  VAL A CB  1 
ATOM   707  C CG1 . VAL A 1 91  ? -16.28197 -49.71093 6.65732   1.000 27.71480 ? 91  VAL A CG1 1 
ATOM   708  C CG2 . VAL A 1 91  ? -16.56913 -50.43589 9.06531   1.000 24.00982 ? 91  VAL A CG2 1 
ATOM   709  N N   . ASP A 1 92  ? -17.23874 -53.91167 7.57863   1.000 25.49695 ? 92  ASP A N   1 
ATOM   710  C CA  . ASP A 1 92  ? -17.43848 -55.24455 8.14130   1.000 25.24894 ? 92  ASP A CA  1 
ATOM   711  C C   . ASP A 1 92  ? -16.72273 -55.45121 9.46901   1.000 37.73087 ? 92  ASP A C   1 
ATOM   712  O O   . ASP A 1 92  ? -16.86985 -56.51854 10.07588  1.000 33.56870 ? 92  ASP A O   1 
ATOM   713  C CB  . ASP A 1 92  ? -16.99924 -56.32135 7.13381   1.000 36.12349 ? 92  ASP A CB  1 
ATOM   714  C CG  . ASP A 1 92  ? -15.50411 -56.30225 6.84867   1.000 35.73470 ? 92  ASP A CG  1 
ATOM   715  O OD1 . ASP A 1 92  ? -14.76663 -55.47634 7.42982   1.000 43.14592 ? 92  ASP A OD1 1 
ATOM   716  O OD2 . ASP A 1 92  ? -15.05823 -57.13251 6.02605   1.000 56.44865 ? 92  ASP A OD2 1 
ATOM   717  N N   . THR A 1 93  ? -15.96113 -54.46595 9.93255   1.000 23.33422 ? 93  THR A N   1 
ATOM   718  C CA  . THR A 1 93  ? -15.17646 -54.57580 11.15483  1.000 23.70429 ? 93  THR A CA  1 
ATOM   719  C C   . THR A 1 93  ? -15.57598 -53.44041 12.08643  1.000 32.08035 ? 93  THR A C   1 
ATOM   720  O O   . THR A 1 93  ? -15.66888 -52.28778 11.65153  1.000 28.56648 ? 93  THR A O   1 
ATOM   721  C CB  . THR A 1 93  ? -13.67822 -54.51517 10.84243  1.000 27.49979 ? 93  THR A CB  1 
ATOM   722  O OG1 . THR A 1 93  ? -13.33769 -55.57571 9.93659   1.000 34.01983 ? 93  THR A OG1 1 
ATOM   723  C CG2 . THR A 1 93  ? -12.83815 -54.64361 12.11874  1.000 28.63909 ? 93  THR A CG2 1 
ATOM   724  N N   . ALA A 1 94  ? -15.84279 -53.76533 13.35245  1.000 21.56106 ? 94  ALA A N   1 
ATOM   725  C CA  . ALA A 1 94  ? -16.04684 -52.73276 14.35789  1.000 22.05757 ? 94  ALA A CA  1 
ATOM   726  C C   . ALA A 1 94  ? -14.69575 -52.18765 14.78935  1.000 23.29765 ? 94  ALA A C   1 
ATOM   727  O O   . ALA A 1 94  ? -13.74544 -52.94673 15.00950  1.000 22.33643 ? 94  ALA A O   1 
ATOM   728  C CB  . ALA A 1 94  ? -16.80816 -53.28532 15.56656  1.000 26.50839 ? 94  ALA A CB  1 
ATOM   729  N N   . ASN A 1 95  ? -14.59961 -50.87003 14.88814  1.000 21.23543 ? 95  ASN A N   1 
ATOM   730  C CA  . ASN A 1 95  ? -13.33349 -50.27094 15.27973  1.000 24.94265 ? 95  ASN A CA  1 
ATOM   731  C C   . ASN A 1 95  ? -13.00083 -50.70065 16.69993  1.000 19.77456 ? 95  ASN A C   1 
ATOM   732  O O   . ASN A 1 95  ? -13.74183 -50.35088 17.62789  1.000 22.10239 ? 95  ASN A O   1 
ATOM   733  C CB  . ASN A 1 95  ? -13.39622 -48.74976 15.18571  1.000 17.74154 ? 95  ASN A CB  1 
ATOM   734  C CG  . ASN A 1 95  ? -12.07069 -48.08707 15.54168  1.000 22.43409 ? 95  ASN A CG  1 
ATOM   735  O OD1 . ASN A 1 95  ? -11.08263 -48.75910 15.82752  1.000 23.83173 ? 95  ASN A OD1 1 
ATOM   736  N ND2 . ASN A 1 95  ? -12.04310 -46.75762 15.49465  1.000 22.05305 ? 95  ASN A ND2 1 
ATOM   737  N N   . PRO A 1 96  ? -11.91534 -51.45429 16.92086  1.000 23.22331 ? 96  PRO A N   1 
ATOM   738  C CA  . PRO A 1 96  ? -11.58836 -51.88841 18.28980  1.000 25.12707 ? 96  PRO A CA  1 
ATOM   739  C C   . PRO A 1 96  ? -11.17122 -50.74832 19.19795  1.000 29.09573 ? 96  PRO A C   1 
ATOM   740  O O   . PRO A 1 96  ? -11.12925 -50.93761 20.42263  1.000 28.34079 ? 96  PRO A O   1 
ATOM   741  C CB  . PRO A 1 96  ? -10.43698 -52.88063 18.08125  1.000 25.98449 ? 96  PRO A CB  1 
ATOM   742  C CG  . PRO A 1 96  ? -9.81913  -52.48530 16.79056  1.000 24.77745 ? 96  PRO A CG  1 
ATOM   743  C CD  . PRO A 1 96  ? -10.94070 -51.94592 15.93090  1.000 23.56299 ? 96  PRO A CD  1 
ATOM   744  N N   . LYS A 1 97  ? -10.88062 -49.57480 18.64032  1.000 27.52755 ? 97  LYS A N   1 
ATOM   745  C CA  . LYS A 1 97  ? -10.51452 -48.39774 19.41516  1.000 24.81498 ? 97  LYS A CA  1 
ATOM   746  C C   . LYS A 1 97  ? -11.68600 -47.44706 19.62586  1.000 27.90246 ? 97  LYS A C   1 
ATOM   747  O O   . LYS A 1 97  ? -11.46068 -46.28950 19.99327  1.000 23.67382 ? 97  LYS A O   1 
ATOM   748  C CB  . LYS A 1 97  ? -9.36851  -47.64294 18.73554  1.000 25.84604 ? 97  LYS A CB  1 
ATOM   749  C CG  . LYS A 1 97  ? -8.11991  -48.46015 18.48591  1.000 29.21250 ? 97  LYS A CG  1 
ATOM   750  C CD  . LYS A 1 97  ? -7.00792  -47.60266 17.90187  1.000 34.73723 ? 97  LYS A CD  1 
ATOM   751  C CE  . LYS A 1 97  ? -5.76836  -48.43606 17.62080  1.000 45.94794 ? 97  LYS A CE  1 
ATOM   752  N NZ  . LYS A 1 97  ? -4.70574  -47.62726 16.97229  1.000 54.85639 ? 97  LYS A NZ  1 
ATOM   753  N N   . THR A 1 98  ? -12.91919 -47.89175 19.38260  1.000 25.80380 ? 98  THR A N   1 
ATOM   754  C CA  . THR A 1 98  ? -14.08758 -47.03711 19.57621  1.000 28.87130 ? 98  THR A CA  1 
ATOM   755  C C   . THR A 1 98  ? -14.19620 -46.62972 21.03932  1.000 29.33557 ? 98  THR A C   1 
ATOM   756  O O   . THR A 1 98  ? -14.36208 -47.50228 21.90748  1.000 25.88752 ? 98  THR A O   1 
ATOM   757  C CB  . THR A 1 98  ? -15.38719 -47.73158 19.16286  1.000 24.81184 ? 98  THR A CB  1 
ATOM   758  O OG1 . THR A 1 98  ? -15.30156 -48.18592 17.81060  1.000 19.35693 ? 98  THR A OG1 1 
ATOM   759  C CG2 . THR A 1 98  ? -16.56824 -46.77699 19.30481  1.000 23.88749 ? 98  THR A CG2 1 
ATOM   760  N N   . PRO A 1 99  ? -14.12254 -45.34344 21.35901  1.000 22.23667 ? 99  PRO A N   1 
ATOM   761  C CA  . PRO A 1 99  ? -14.34838 -44.90918 22.73792  1.000 24.83390 ? 99  PRO A CA  1 
ATOM   762  C C   . PRO A 1 99  ? -15.83917 -44.91295 23.03329  1.000 22.92406 ? 99  PRO A C   1 
ATOM   763  O O   . PRO A 1 99  ? -16.67406 -45.02577 22.13237  1.000 25.61332 ? 99  PRO A O   1 
ATOM   764  C CB  . PRO A 1 99  ? -13.78300 -43.48730 22.74745  1.000 22.43654 ? 99  PRO A CB  1 
ATOM   765  C CG  . PRO A 1 99  ? -14.06447 -42.99217 21.34902  1.000 24.24873 ? 99  PRO A CG  1 
ATOM   766  C CD  . PRO A 1 99  ? -13.93715 -44.19679 20.43995  1.000 20.21047 ? 99  PRO A CD  1 
ATOM   767  N N   . LYS A 1 100 ? -16.17142 -44.79378 24.31453  1.000 25.83300 ? 100 LYS A N   1 
ATOM   768  C CA  . LYS A 1 100 ? -17.53727 -44.43223 24.65548  1.000 23.66732 ? 100 LYS A CA  1 
ATOM   769  C C   . LYS A 1 100 ? -17.81413 -43.06259 24.04503  1.000 26.23163 ? 100 LYS A C   1 
ATOM   770  O O   . LYS A 1 100 ? -16.98371 -42.15263 24.14299  1.000 25.82092 ? 100 LYS A O   1 
ATOM   771  C CB  . LYS A 1 100 ? -17.73880 -44.41641 26.17076  1.000 29.53508 ? 100 LYS A CB  1 
ATOM   772  N N   . TYR A 1 101 ? -18.94475 -42.92695 23.35997  1.000 23.98929 ? 101 TYR A N   1 
ATOM   773  C CA  . TYR A 1 101 ? -19.18244 -41.69012 22.62705  1.000 24.05734 ? 101 TYR A CA  1 
ATOM   774  C C   . TYR A 1 101 ? -20.66871 -41.39284 22.52584  1.000 26.15920 ? 101 TYR A C   1 
ATOM   775  O O   . TYR A 1 101 ? -21.52162 -42.28260 22.62769  1.000 22.94936 ? 101 TYR A O   1 
ATOM   776  C CB  . TYR A 1 101 ? -18.56962 -41.72816 21.21544  1.000 17.32801 ? 101 TYR A CB  1 
ATOM   777  C CG  . TYR A 1 101 ? -19.32619 -42.60741 20.23906  1.000 20.74019 ? 101 TYR A CG  1 
ATOM   778  C CD1 . TYR A 1 101 ? -19.09958 -43.98128 20.19879  1.000 25.86665 ? 101 TYR A CD1 1 
ATOM   779  C CD2 . TYR A 1 101 ? -20.25696 -42.07077 19.35383  1.000 22.38353 ? 101 TYR A CD2 1 
ATOM   780  C CE1 . TYR A 1 101 ? -19.78045 -44.79331 19.31760  1.000 28.07700 ? 101 TYR A CE1 1 
ATOM   781  C CE2 . TYR A 1 101 ? -20.94765 -42.88480 18.45840  1.000 22.62784 ? 101 TYR A CE2 1 
ATOM   782  C CZ  . TYR A 1 101 ? -20.69854 -44.24548 18.44574  1.000 26.44292 ? 101 TYR A CZ  1 
ATOM   783  O OH  . TYR A 1 101 ? -21.37943 -45.06124 17.56976  1.000 29.18985 ? 101 TYR A OH  1 
ATOM   784  N N   . LYS A 1 102 ? -20.95723 -40.10982 22.30713  1.000 21.71606 ? 102 LYS A N   1 
ATOM   785  C CA  . LYS A 1 102 ? -22.27156 -39.62464 21.90673  1.000 22.24453 ? 102 LYS A CA  1 
ATOM   786  C C   . LYS A 1 102 ? -22.11128 -38.62940 20.76204  1.000 20.27241 ? 102 LYS A C   1 
ATOM   787  O O   . LYS A 1 102 ? -21.04251 -38.04158 20.57202  1.000 18.88503 ? 102 LYS A O   1 
ATOM   788  C CB  . LYS A 1 102 ? -23.01346 -38.93918 23.06423  1.000 26.33458 ? 102 LYS A CB  1 
ATOM   789  C CG  . LYS A 1 102 ? -23.08318 -39.73979 24.35182  1.000 43.71666 ? 102 LYS A CG  1 
ATOM   790  C CD  . LYS A 1 102 ? -24.16817 -39.19962 25.27141  1.000 47.05940 ? 102 LYS A CD  1 
ATOM   791  C CE  . LYS A 1 102 ? -24.08553 -37.68543 25.43184  1.000 51.90538 ? 102 LYS A CE  1 
ATOM   792  N NZ  . LYS A 1 102 ? -22.90350 -37.23267 26.20984  1.000 47.77458 ? 102 LYS A NZ  1 
ATOM   793  N N   . PHE A 1 103 ? -23.18621 -38.45352 19.99232  1.000 23.29668 ? 103 PHE A N   1 
ATOM   794  C CA  . PHE A 1 103 ? -23.31759 -37.34571 19.05278  1.000 18.44556 ? 103 PHE A CA  1 
ATOM   795  C C   . PHE A 1 103 ? -24.17340 -36.25987 19.68614  1.000 22.22090 ? 103 PHE A C   1 
ATOM   796  O O   . PHE A 1 103 ? -25.28176 -36.53910 20.16485  1.000 25.22045 ? 103 PHE A O   1 
ATOM   797  C CB  . PHE A 1 103 ? -23.97574 -37.78204 17.74177  1.000 17.98797 ? 103 PHE A CB  1 
ATOM   798  C CG  . PHE A 1 103 ? -23.15806 -38.73218 16.91038  1.000 21.10641 ? 103 PHE A CG  1 
ATOM   799  C CD1 . PHE A 1 103 ? -21.81046 -38.92619 17.14746  1.000 18.70708 ? 103 PHE A CD1 1 
ATOM   800  C CD2 . PHE A 1 103 ? -23.75197 -39.42119 15.85751  1.000 19.56504 ? 103 PHE A CD2 1 
ATOM   801  C CE1 . PHE A 1 103 ? -21.06363 -39.79073 16.35870  1.000 17.39123 ? 103 PHE A CE1 1 
ATOM   802  C CE2 . PHE A 1 103 ? -23.01667 -40.28974 15.07242  1.000 17.25374 ? 103 PHE A CE2 1 
ATOM   803  C CZ  . PHE A 1 103 ? -21.65887 -40.46969 15.31954  1.000 17.66455 ? 103 PHE A CZ  1 
ATOM   804  N N   . VAL A 1 104 ? -23.68238 -35.02416 19.67402  1.000 17.46804 ? 104 VAL A N   1 
ATOM   805  C CA  . VAL A 1 104 ? -24.41807 -33.90535 20.24794  1.000 19.25639 ? 104 VAL A CA  1 
ATOM   806  C C   . VAL A 1 104 ? -24.41129 -32.73469 19.27683  1.000 22.34797 ? 104 VAL A C   1 
ATOM   807  O O   . VAL A 1 104 ? -23.44517 -32.50108 18.54490  1.000 21.59356 ? 104 VAL A O   1 
ATOM   808  C CB  . VAL A 1 104 ? -23.85633 -33.47216 21.62883  1.000 20.70426 ? 104 VAL A CB  1 
ATOM   809  C CG1 . VAL A 1 104 ? -23.70153 -34.67864 22.55420  1.000 26.53793 ? 104 VAL A CG1 1 
ATOM   810  C CG2 . VAL A 1 104 ? -22.54591 -32.74168 21.47271  1.000 29.83619 ? 104 VAL A CG2 1 
ATOM   811  N N   . ARG A 1 105 ? -25.50857 -31.99667 19.25809  1.000 19.94820 ? 105 ARG A N   1 
ATOM   812  C CA  . ARG A 1 105 ? -25.54908 -30.74146 18.53378  1.000 17.33669 ? 105 ARG A CA  1 
ATOM   813  C C   . ARG A 1 105 ? -25.33704 -29.63245 19.55653  1.000 22.81988 ? 105 ARG A C   1 
ATOM   814  O O   . ARG A 1 105 ? -26.14688 -29.47110 20.47764  1.000 27.25526 ? 105 ARG A O   1 
ATOM   815  C CB  . ARG A 1 105 ? -26.87019 -30.58000 17.77579  1.000 18.98786 ? 105 ARG A CB  1 
ATOM   816  C CG  . ARG A 1 105 ? -26.87088 -29.40667 16.78714  1.000 20.16404 ? 105 ARG A CG  1 
ATOM   817  C CD  . ARG A 1 105 ? -28.10742 -29.37981 15.91322  1.000 22.86630 ? 105 ARG A CD  1 
ATOM   818  N NE  . ARG A 1 105 ? -28.14464 -28.16134 15.11433  1.000 31.84457 ? 105 ARG A NE  1 
ATOM   819  C CZ  . ARG A 1 105 ? -27.52706 -28.01643 13.94882  1.000 24.26839 ? 105 ARG A CZ  1 
ATOM   820  N NH1 . ARG A 1 105 ? -26.83762 -29.00737 13.40821  1.000 20.59724 ? 105 ARG A NH1 1 
ATOM   821  N NH2 . ARG A 1 105 ? -27.59146 -26.84363 13.31802  1.000 18.58679 ? 105 ARG A NH2 1 
ATOM   822  N N   . ILE A 1 106 ? -24.23102 -28.90034 19.42458  1.000 18.98227 ? 106 ILE A N   1 
ATOM   823  C CA  . ILE A 1 106 ? -23.89391 -27.88884 20.41504  1.000 20.95960 ? 106 ILE A CA  1 
ATOM   824  C C   . ILE A 1 106 ? -24.59443 -26.58644 20.06844  1.000 18.48251 ? 106 ILE A C   1 
ATOM   825  O O   . ILE A 1 106 ? -25.07648 -26.37550 18.94910  1.000 22.85849 ? 106 ILE A O   1 
ATOM   826  C CB  . ILE A 1 106 ? -22.38084 -27.66739 20.54070  1.000 24.63227 ? 106 ILE A CB  1 
ATOM   827  C CG1 . ILE A 1 106 ? -21.78873 -27.37175 19.17073  1.000 18.81518 ? 106 ILE A CG1 1 
ATOM   828  C CG2 . ILE A 1 106 ? -21.72940 -28.87570 21.19612  1.000 29.61851 ? 106 ILE A CG2 1 
ATOM   829  C CD1 . ILE A 1 106 ? -20.45827 -26.66163 19.21414  1.000 27.47263 ? 106 ILE A CD1 1 
ATOM   830  N N   . GLN A 1 107 ? -24.64864 -25.74804 21.00784  1.000 21.44661 ? 107 GLN A N   1 
ATOM   831  C CA  . GLN A 1 107 ? -25.25914 -24.43799 20.91195  1.000 21.19624 ? 107 GLN A CA  1 
ATOM   832  C C   . GLN A 1 107 ? -24.20765 -23.40126 20.54092  1.000 20.86677 ? 107 GLN A C   1 
ATOM   833  O O   . GLN A 1 107 ? -23.03245 -23.55515 20.88360  1.000 18.98802 ? 107 GLN A O   1 
ATOM   834  C CB  . GLN A 1 107 ? -25.90860 -24.05774 22.24254  1.000 25.42945 ? 107 GLN A CB  1 
ATOM   835  C CG  . GLN A 1 107 ? -27.07651 -24.95312 22.62503  1.000 28.95044 ? 107 GLN A CG  1 
ATOM   836  C CD  . GLN A 1 107 ? -28.21451 -24.84727 21.62681  1.000 32.77421 ? 107 GLN A CD  1 
ATOM   837  O OE1 . GLN A 1 107 ? -28.73591 -23.75952 21.37961  1.000 46.45092 ? 107 GLN A OE1 1 
ATOM   838  N NE2 . GLN A 1 107 ? -28.59492 -25.97518 21.03490  1.000 40.68476 ? 107 GLN A NE2 1 
ATOM   839  N N   . PRO A 1 108 ? -24.58619 -22.34224 19.82442  1.000 19.83300 ? 108 PRO A N   1 
ATOM   840  C CA  . PRO A 1 108 ? -23.61866 -21.27704 19.54536  1.000 18.43613 ? 108 PRO A CA  1 
ATOM   841  C C   . PRO A 1 108 ? -23.06733 -20.72296 20.84584  1.000 20.03117 ? 108 PRO A C   1 
ATOM   842  O O   . PRO A 1 108 ? -23.77913 -20.62252 21.85082  1.000 19.72977 ? 108 PRO A O   1 
ATOM   843  C CB  . PRO A 1 108 ? -24.44816 -20.22887 18.78893  1.000 26.39953 ? 108 PRO A CB  1 
ATOM   844  C CG  . PRO A 1 108 ? -25.86226 -20.47666 19.26063  1.000 30.55188 ? 108 PRO A CG  1 
ATOM   845  C CD  . PRO A 1 108 ? -25.95197 -21.96923 19.41219  1.000 24.51816 ? 108 PRO A CD  1 
ATOM   846  N N   . GLY A 1 109 ? -21.77823 -20.38559 20.82779  1.000 15.99471 ? 109 GLY A N   1 
ATOM   847  C CA  . GLY A 1 109 ? -21.09584 -19.91937 22.01019  1.000 16.96951 ? 109 GLY A CA  1 
ATOM   848  C C   . GLY A 1 109 ? -20.44113 -21.00771 22.82495  1.000 20.47539 ? 109 GLY A C   1 
ATOM   849  O O   . GLY A 1 109 ? -19.64438 -20.69435 23.71789  1.000 23.30898 ? 109 GLY A O   1 
ATOM   850  N N   . GLN A 1 110 ? -20.76552 -22.27235 22.56938  1.000 17.04730 ? 110 GLN A N   1 
ATOM   851  C CA  A GLN A 1 110 ? -20.05533 -23.35434 23.23589  0.500 18.17507 ? 110 GLN A CA  1 
ATOM   852  C CA  B GLN A 1 110 ? -20.04788 -23.34573 23.23803  0.500 18.17842 ? 110 GLN A CA  1 
ATOM   853  C C   . GLN A 1 110 ? -18.72534 -23.61831 22.53066  1.000 18.92432 ? 110 GLN A C   1 
ATOM   854  O O   . GLN A 1 110 ? -18.51009 -23.23309 21.37885  1.000 19.37191 ? 110 GLN A O   1 
ATOM   855  C CB  A GLN A 1 110 ? -20.89255 -24.63977 23.27989  0.500 15.90648 ? 110 GLN A CB  1 
ATOM   856  C CB  B GLN A 1 110 ? -20.88427 -24.62059 23.29189  0.500 15.87575 ? 110 GLN A CB  1 
ATOM   857  C CG  A GLN A 1 110 ? -22.22531 -24.54234 24.05370  0.500 22.97640 ? 110 GLN A CG  1 
ATOM   858  C CG  B GLN A 1 110 ? -22.10869 -24.50570 24.18094  0.500 22.97078 ? 110 GLN A CG  1 
ATOM   859  C CD  A GLN A 1 110 ? -22.86910 -25.90924 24.32558  0.500 31.11616 ? 110 GLN A CD  1 
ATOM   860  C CD  B GLN A 1 110 ? -21.74078 -24.22379 25.62082  0.500 24.57658 ? 110 GLN A CD  1 
ATOM   861  O OE1 A GLN A 1 110 ? -23.77072 -26.35093 23.60377  0.500 18.97388 ? 110 GLN A OE1 1 
ATOM   862  O OE1 B GLN A 1 110 ? -22.01712 -23.14373 26.14427  0.500 28.86471 ? 110 GLN A OE1 1 
ATOM   863  N NE2 A GLN A 1 110 ? -22.41013 -26.57726 25.38123  0.500 30.77945 ? 110 GLN A NE2 1 
ATOM   864  N NE2 B GLN A 1 110 ? -21.10397 -25.19507 26.27108  0.500 26.75766 ? 110 GLN A NE2 1 
ATOM   865  N N   . THR A 1 111 ? -17.83372 -24.30477 23.23507  1.000 18.43292 ? 111 THR A N   1 
ATOM   866  C CA  . THR A 1 111 ? -16.48980 -24.54566 22.73633  1.000 15.61557 ? 111 THR A CA  1 
ATOM   867  C C   . THR A 1 111 ? -16.28790 -26.03552 22.52390  1.000 14.45656 ? 111 THR A C   1 
ATOM   868  O O   . THR A 1 111 ? -17.03552 -26.86698 23.05389  1.000 21.42535 ? 111 THR A O   1 
ATOM   869  C CB  . THR A 1 111 ? -15.43434 -24.00925 23.71131  1.000 16.12625 ? 111 THR A CB  1 
ATOM   870  O OG1 . THR A 1 111 ? -15.66388 -24.61393 24.98502  1.000 21.09348 ? 111 THR A OG1 1 
ATOM   871  C CG2 . THR A 1 111 ? -15.55564 -22.50046 23.81098  1.000 21.14044 ? 111 THR A CG2 1 
ATOM   872  N N   . PHE A 1 112 ? -15.25060 -26.35518 21.75061  1.000 16.21449 ? 112 PHE A N   1 
ATOM   873  C CA  . PHE A 1 112 ? -14.89545 -27.74705 21.51099  1.000 13.47049 ? 112 PHE A CA  1 
ATOM   874  C C   . PHE A 1 112 ? -13.48122 -27.82123 20.96458  1.000 12.91442 ? 112 PHE A C   1 
ATOM   875  O O   . PHE A 1 112 ? -12.91583 -26.82603 20.51408  1.000 16.05537 ? 112 PHE A O   1 
ATOM   876  C CB  . PHE A 1 112 ? -15.89439 -28.42471 20.55463  1.000 13.95491 ? 112 PHE A CB  1 
ATOM   877  C CG  . PHE A 1 112 ? -16.06111 -27.74047 19.20983  1.000 12.44489 ? 112 PHE A CG  1 
ATOM   878  C CD1 . PHE A 1 112 ? -16.94220 -26.67830 19.06231  1.000 20.23868 ? 112 PHE A CD1 1 
ATOM   879  C CD2 . PHE A 1 112 ? -15.37235 -28.18450 18.09923  1.000 12.17826 ? 112 PHE A CD2 1 
ATOM   880  C CE1 . PHE A 1 112 ? -17.12272 -26.07597 17.81969  1.000 21.74671 ? 112 PHE A CE1 1 
ATOM   881  C CE2 . PHE A 1 112 ? -15.56717 -27.58856 16.83225  1.000 15.64468 ? 112 PHE A CE2 1 
ATOM   882  C CZ  . PHE A 1 112 ? -16.42513 -26.52489 16.71528  1.000 17.02344 ? 112 PHE A CZ  1 
ATOM   883  N N   . SER A 1 113 ? -12.91797 -29.03455 20.99863  1.000 13.47340 ? 113 SER A N   1 
ATOM   884  C CA  . SER A 1 113 ? -11.59774 -29.28043 20.43096  1.000 12.53402 ? 113 SER A CA  1 
ATOM   885  C C   . SER A 1 113 ? -11.74789 -29.84980 19.03360  1.000 14.64112 ? 113 SER A C   1 
ATOM   886  O O   . SER A 1 113 ? -12.63302 -30.67062 18.79283  1.000 16.90466 ? 113 SER A O   1 
ATOM   887  C CB  . SER A 1 113 ? -10.79245 -30.26586 21.27169  1.000 15.56701 ? 113 SER A CB  1 
ATOM   888  O OG  . SER A 1 113 ? -10.59773 -29.73897 22.56643  1.000 16.27685 ? 113 SER A OG  1 
ATOM   889  N N   . VAL A 1 114 ? -10.86828 -29.41968 18.13336  1.000 15.92944 ? 114 VAL A N   1 
ATOM   890  C CA  . VAL A 1 114 ? -10.81443 -29.89465 16.75416  1.000 15.05196 ? 114 VAL A CA  1 
ATOM   891  C C   . VAL A 1 114 ? -9.53188  -30.67959 16.57300  1.000 17.10451 ? 114 VAL A C   1 
ATOM   892  O O   . VAL A 1 114 ? -8.45039  -30.16221 16.85813  1.000 17.05667 ? 114 VAL A O   1 
ATOM   893  C CB  . VAL A 1 114 ? -10.84191 -28.72864 15.75089  1.000 13.74380 ? 114 VAL A CB  1 
ATOM   894  C CG1 . VAL A 1 114 ? -10.60885 -29.25808 14.33992  1.000 16.33363 ? 114 VAL A CG1 1 
ATOM   895  C CG2 . VAL A 1 114 ? -12.13839 -27.99038 15.86919  1.000 17.00250 ? 114 VAL A CG2 1 
ATOM   896  N N   . LEU A 1 115 ? -9.63808  -31.91093 16.07085  1.000 14.68241 ? 115 LEU A N   1 
ATOM   897  C CA  . LEU A 1 115 ? -8.45265  -32.66404 15.67662  1.000 14.53557 ? 115 LEU A CA  1 
ATOM   898  C C   . LEU A 1 115 ? -8.31924  -32.49053 14.17285  1.000 15.35651 ? 115 LEU A C   1 
ATOM   899  O O   . LEU A 1 115 ? -9.02809  -33.13762 13.39481  1.000 16.04201 ? 115 LEU A O   1 
ATOM   900  C CB  . LEU A 1 115 ? -8.54854  -34.13068 16.08217  1.000 12.55205 ? 115 LEU A CB  1 
ATOM   901  C CG  . LEU A 1 115 ? -7.35913  -34.99169 15.66748  1.000 13.39870 ? 115 LEU A CG  1 
ATOM   902  C CD1 . LEU A 1 115 ? -6.06470  -34.59184 16.40789  1.000 18.48354 ? 115 LEU A CD1 1 
ATOM   903  C CD2 . LEU A 1 115 ? -7.69264  -36.46506 15.88171  1.000 15.63404 ? 115 LEU A CD2 1 
ATOM   904  N N   . ALA A 1 116 ? -7.43129  -31.58875 13.75778  1.000 14.24232 ? 116 ALA A N   1 
ATOM   905  C CA  . ALA A 1 116 ? -7.20690  -31.37112 12.33692  1.000 18.34789 ? 116 ALA A CA  1 
ATOM   906  C C   . ALA A 1 116 ? -6.45962  -32.56210 11.75529  1.000 17.57380 ? 116 ALA A C   1 
ATOM   907  O O   . ALA A 1 116 ? -5.46749  -33.01723 12.33022  1.000 18.87225 ? 116 ALA A O   1 
ATOM   908  C CB  . ALA A 1 116 ? -6.41402  -30.08235 12.11621  1.000 23.07198 ? 116 ALA A CB  1 
ATOM   909  N N   . CYS A 1 117 ? -6.95869  -33.08971 10.63369  1.000 15.43032 ? 117 CYS A N   1 
ATOM   910  C CA  . CYS A 1 117 ? -6.40439  -34.28158 9.99803   1.000 17.22540 ? 117 CYS A CA  1 
ATOM   911  C C   . CYS A 1 117 ? -6.30060  -34.09093 8.49193   1.000 20.44748 ? 117 CYS A C   1 
ATOM   912  O O   . CYS A 1 117 ? -7.10604  -33.38423 7.88205   1.000 17.02445 ? 117 CYS A O   1 
ATOM   913  C CB  . CYS A 1 117 ? -7.27481  -35.52323 10.23367  1.000 18.51589 ? 117 CYS A CB  1 
ATOM   914  S SG  . CYS A 1 117 ? -7.43140  -36.01289 11.93146  1.000 20.88601 ? 117 CYS A SG  1 
ATOM   915  N N   . TYR A 1 118 ? -5.33104  -34.78594 7.88662   1.000 17.10283 ? 118 TYR A N   1 
ATOM   916  C CA  . TYR A 1 118 ? -5.17351  -34.84137 6.43316   1.000 23.02258 ? 118 TYR A CA  1 
ATOM   917  C C   . TYR A 1 118 ? -4.88191  -36.28249 6.04426   1.000 19.09686 ? 118 TYR A C   1 
ATOM   918  O O   . TYR A 1 118 ? -4.08873  -36.95293 6.71437   1.000 21.76752 ? 118 TYR A O   1 
ATOM   919  C CB  . TYR A 1 118 ? -4.04843  -33.90097 5.97500   1.000 22.50107 ? 118 TYR A CB  1 
ATOM   920  C CG  . TYR A 1 118 ? -4.35758  -32.48577 6.37980   1.000 28.08637 ? 118 TYR A CG  1 
ATOM   921  C CD1 . TYR A 1 118 ? -3.97548  -31.99379 7.62588   1.000 26.48821 ? 118 TYR A CD1 1 
ATOM   922  C CD2 . TYR A 1 118 ? -5.10328  -31.66263 5.54459   1.000 26.95459 ? 118 TYR A CD2 1 
ATOM   923  C CE1 . TYR A 1 118 ? -4.30143  -30.70161 8.01056   1.000 32.36708 ? 118 TYR A CE1 1 
ATOM   924  C CE2 . TYR A 1 118 ? -5.43277  -30.37966 5.91591   1.000 25.90013 ? 118 TYR A CE2 1 
ATOM   925  C CZ  . TYR A 1 118 ? -5.03651  -29.90450 7.14499   1.000 24.74582 ? 118 TYR A CZ  1 
ATOM   926  O OH  . TYR A 1 118 ? -5.37094  -28.62522 7.51235   1.000 29.32673 ? 118 TYR A OH  1 
ATOM   927  N N   . ASN A 1 119 ? -5.55702  -36.76722 4.99004   1.000 24.96193 ? 119 ASN A N   1 
ATOM   928  C CA  . ASN A 1 119 ? -5.36988  -38.14295 4.52304   1.000 28.18187 ? 119 ASN A CA  1 
ATOM   929  C C   . ASN A 1 119 ? -5.59498  -39.16456 5.63999   1.000 28.46966 ? 119 ASN A C   1 
ATOM   930  O O   . ASN A 1 119 ? -4.95971  -40.21915 5.66805   1.000 31.07457 ? 119 ASN A O   1 
ATOM   931  C CB  . ASN A 1 119 ? -3.97782  -38.32541 3.91282   1.000 28.28107 ? 119 ASN A CB  1 
ATOM   932  C CG  . ASN A 1 119 ? -3.80062  -37.54185 2.63904   1.000 50.62970 ? 119 ASN A CG  1 
ATOM   933  O OD1 . ASN A 1 119 ? -2.89992  -36.71019 2.52915   1.000 62.51861 ? 119 ASN A OD1 1 
ATOM   934  N ND2 . ASN A 1 119 ? -4.66879  -37.79260 1.66529   1.000 50.52113 ? 119 ASN A ND2 1 
ATOM   935  N N   . GLY A 1 120 ? -6.48991  -38.86031 6.58271   1.000 19.75563 ? 120 GLY A N   1 
ATOM   936  C CA  . GLY A 1 120 ? -6.76385  -39.75950 7.68006   1.000 19.04986 ? 120 GLY A CA  1 
ATOM   937  C C   . GLY A 1 120 ? -5.76543  -39.71301 8.81801   1.000 21.02843 ? 120 GLY A C   1 
ATOM   938  O O   . GLY A 1 120 ? -5.88998  -40.50957 9.75797   1.000 26.02593 ? 120 GLY A O   1 
ATOM   939  N N   . SER A 1 121 ? -4.79226  -38.79880 8.76763   1.000 20.44999 ? 121 SER A N   1 
ATOM   940  C CA  . SER A 1 121 ? -3.72486  -38.71761 9.74390   1.000 23.86989 ? 121 SER A CA  1 
ATOM   941  C C   . SER A 1 121 ? -3.81084  -37.42415 10.53714  1.000 20.87133 ? 121 SER A C   1 
ATOM   942  O O   . SER A 1 121 ? -3.91453  -36.33624 9.95399   1.000 22.35342 ? 121 SER A O   1 
ATOM   943  C CB  . SER A 1 121 ? -2.36790  -38.82276 9.05842   1.000 28.70315 ? 121 SER A CB  1 
ATOM   944  O OG  . SER A 1 121 ? -2.20638  -40.13471 8.54808   1.000 31.82675 ? 121 SER A OG  1 
ATOM   945  N N   . PRO A 1 122 ? -3.80839  -37.51703 11.86056  1.000 23.05980 ? 122 PRO A N   1 
ATOM   946  C CA  . PRO A 1 122 ? -3.93114  -36.31040 12.68629  1.000 19.30112 ? 122 PRO A CA  1 
ATOM   947  C C   . PRO A 1 122 ? -2.70012  -35.42989 12.57894  1.000 26.11806 ? 122 PRO A C   1 
ATOM   948  O O   . PRO A 1 122 ? -1.56765  -35.91301 12.58087  1.000 27.01620 ? 122 PRO A O   1 
ATOM   949  C CB  . PRO A 1 122 ? -4.09652  -36.87382 14.10293  1.000 24.87918 ? 122 PRO A CB  1 
ATOM   950  C CG  . PRO A 1 122 ? -4.66207  -38.26978 13.89452  1.000 40.52936 ? 122 PRO A CG  1 
ATOM   951  C CD  . PRO A 1 122 ? -3.96319  -38.75576 12.64470  1.000 25.78608 ? 122 PRO A CD  1 
ATOM   952  N N   . SER A 1 123 ? -2.92379  -34.12083 12.47179  1.000 20.71074 ? 123 SER A N   1 
ATOM   953  C CA  . SER A 1 123 ? -1.80382  -33.19202 12.44419  1.000 25.74543 ? 123 SER A CA  1 
ATOM   954  C C   . SER A 1 123 ? -1.74050  -32.27335 13.65394  1.000 20.58158 ? 123 SER A C   1 
ATOM   955  O O   . SER A 1 123 ? -0.64188  -31.91192 14.06710  1.000 22.50849 ? 123 SER A O   1 
ATOM   956  C CB  . SER A 1 123 ? -1.82431  -32.34701 11.16596  1.000 31.99227 ? 123 SER A CB  1 
ATOM   957  O OG  . SER A 1 123 ? -2.96095  -31.52055 11.11377  1.000 34.84832 ? 123 SER A OG  1 
ATOM   958  N N   . GLY A 1 124 ? -2.86870  -31.89896 14.24743  1.000 16.78320 ? 124 GLY A N   1 
ATOM   959  C CA  . GLY A 1 124 ? -2.81032  -31.04949 15.42712  1.000 15.57444 ? 124 GLY A CA  1 
ATOM   960  C C   . GLY A 1 124 ? -4.18244  -30.92177 16.04907  1.000 19.58475 ? 124 GLY A C   1 
ATOM   961  O O   . GLY A 1 124 ? -5.18387  -31.37767 15.49112  1.000 19.83381 ? 124 GLY A O   1 
ATOM   962  N N   . VAL A 1 125 ? -4.21309  -30.30410 17.22788  1.000 15.04544 ? 125 VAL A N   1 
ATOM   963  C CA  . VAL A 1 125 ? -5.44387  -30.17492 17.99918  1.000 15.25152 ? 125 VAL A CA  1 
ATOM   964  C C   . VAL A 1 125 ? -5.53113  -28.75498 18.56350  1.000 20.05773 ? 125 VAL A C   1 
ATOM   965  O O   . VAL A 1 125 ? -4.53414  -28.19653 19.03644  1.000 18.91523 ? 125 VAL A O   1 
ATOM   966  C CB  . VAL A 1 125 ? -5.52059  -31.25400 19.10496  1.000 21.26232 ? 125 VAL A CB  1 
ATOM   967  C CG1 . VAL A 1 125 ? -4.40614  -31.09527 20.11719  1.000 26.76723 ? 125 VAL A CG1 1 
ATOM   968  C CG2 . VAL A 1 125 ? -6.89352  -31.26463 19.78944  1.000 21.55903 ? 125 VAL A CG2 1 
ATOM   969  N N   . TYR A 1 126 ? -6.70480  -28.13960 18.45535  1.000 15.65254 ? 126 TYR A N   1 
ATOM   970  C CA  . TYR A 1 126 ? -6.88153  -26.82191 19.04295  1.000 16.20748 ? 126 TYR A CA  1 
ATOM   971  C C   . TYR A 1 126 ? -8.31525  -26.67253 19.52847  1.000 16.93847 ? 126 TYR A C   1 
ATOM   972  O O   . TYR A 1 126 ? -9.21145  -27.40861 19.12097  1.000 16.90977 ? 126 TYR A O   1 
ATOM   973  C CB  . TYR A 1 126 ? -6.51851  -25.71074 18.05076  1.000 16.56273 ? 126 TYR A CB  1 
ATOM   974  C CG  . TYR A 1 126 ? -7.28476  -25.77693 16.76173  1.000 17.89254 ? 126 TYR A CG  1 
ATOM   975  C CD1 . TYR A 1 126 ? -8.49969  -25.13382 16.62505  1.000 18.46222 ? 126 TYR A CD1 1 
ATOM   976  C CD2 . TYR A 1 126 ? -6.79581  -26.49745 15.69122  1.000 21.19438 ? 126 TYR A CD2 1 
ATOM   977  C CE1 . TYR A 1 126 ? -9.20400  -25.20217 15.44662  1.000 18.83347 ? 126 TYR A CE1 1 
ATOM   978  C CE2 . TYR A 1 126 ? -7.49454  -26.56621 14.49932  1.000 23.38888 ? 126 TYR A CE2 1 
ATOM   979  C CZ  . TYR A 1 126 ? -8.69359  -25.91432 14.39339  1.000 19.27669 ? 126 TYR A CZ  1 
ATOM   980  O OH  . TYR A 1 126 ? -9.38556  -25.97728 13.20431  1.000 23.40089 ? 126 TYR A OH  1 
ATOM   981  N N   . GLN A 1 127 ? -8.51406  -25.68612 20.39737  1.000 19.37950 ? 127 GLN A N   1 
ATOM   982  C CA  . GLN A 1 127 ? -9.79351  -25.38650 21.02381  1.000 15.76864 ? 127 GLN A CA  1 
ATOM   983  C C   . GLN A 1 127 ? -10.40326 -24.18815 20.31720  1.000 23.24894 ? 127 GLN A C   1 
ATOM   984  O O   . GLN A 1 127 ? -9.69826  -23.23468 19.97595  1.000 29.70745 ? 127 GLN A O   1 
ATOM   985  C CB  . GLN A 1 127 ? -9.58039  -25.09543 22.52159  1.000 18.45412 ? 127 GLN A CB  1 
ATOM   986  C CG  . GLN A 1 127 ? -10.81976 -24.87320 23.35093  1.000 20.24730 ? 127 GLN A CG  1 
ATOM   987  C CD  . GLN A 1 127 ? -11.50496 -26.15380 23.76005  1.000 19.16254 ? 127 GLN A CD  1 
ATOM   988  O OE1 . GLN A 1 127 ? -11.12136 -27.24923 23.33587  1.000 25.57739 ? 127 GLN A OE1 1 
ATOM   989  N NE2 . GLN A 1 127 ? -12.53102 -26.02673 24.58083  1.000 23.65656 ? 127 GLN A NE2 1 
ATOM   990  N N   . CYS A 1 128 ? -11.70609 -24.24453 20.06533  1.000 19.91534 ? 128 CYS A N   1 
ATOM   991  C CA  . CYS A 1 128 ? -12.36677 -23.09041 19.47993  1.000 29.50149 ? 128 CYS A CA  1 
ATOM   992  C C   . CYS A 1 128 ? -13.81911 -23.04532 19.91174  1.000 24.41027 ? 128 CYS A C   1 
ATOM   993  O O   . CYS A 1 128 ? -14.34236 -23.97275 20.52343  1.000 21.07724 ? 128 CYS A O   1 
ATOM   994  C CB  . CYS A 1 128 ? -12.30221 -23.12229 17.96974  1.000 23.34050 ? 128 CYS A CB  1 
ATOM   995  S SG  . CYS A 1 128 ? -13.24628 -24.50001 17.34688  1.000 24.96377 ? 128 CYS A SG  1 
ATOM   996  N N   . ALA A 1 129 ? -14.46919 -21.94496 19.56032  1.000 20.92654 ? 129 ALA A N   1 
ATOM   997  C CA  . ALA A 1 129 ? -15.87258 -21.74626 19.86118  1.000 17.52880 ? 129 ALA A CA  1 
ATOM   998  C C   . ALA A 1 129 ? -16.69716 -21.77486 18.58770  1.000 17.36748 ? 129 ALA A C   1 
ATOM   999  O O   . ALA A 1 129 ? -16.25172 -21.34363 17.52295  1.000 21.53416 ? 129 ALA A O   1 
ATOM   1000 C CB  . ALA A 1 129 ? -16.10378 -20.40828 20.55489  1.000 15.77439 ? 129 ALA A CB  1 
ATOM   1001 N N   . MET A 1 130 ? -17.90943 -22.27944 18.72264  1.000 15.25210 ? 130 MET A N   1 
ATOM   1002 C CA  A MET A 1 130 ? -18.92939 -22.06153 17.70255  0.700 15.42586 ? 130 MET A CA  1 
ATOM   1003 C CA  B MET A 1 130 ? -18.91087 -22.05055 17.69583  0.300 15.50892 ? 130 MET A CA  1 
ATOM   1004 C C   . MET A 1 130 ? -19.38850 -20.61077 17.79643  1.000 18.30611 ? 130 MET A C   1 
ATOM   1005 O O   . MET A 1 130 ? -19.93819 -20.19939 18.82548  1.000 18.39773 ? 130 MET A O   1 
ATOM   1006 C CB  A MET A 1 130 ? -20.09539 -23.02349 17.92104  0.700 16.22229 ? 130 MET A CB  1 
ATOM   1007 C CB  B MET A 1 130 ? -20.07820 -23.00881 17.85752  0.300 16.30740 ? 130 MET A CB  1 
ATOM   1008 C CG  A MET A 1 130 ? -21.23972 -22.91154 16.91990  0.700 21.75070 ? 130 MET A CG  1 
ATOM   1009 C CG  B MET A 1 130 ? -21.20187 -22.66089 16.92667  0.300 21.36624 ? 130 MET A CG  1 
ATOM   1010 S SD  A MET A 1 130 ? -20.83391 -23.32021 15.19879  0.700 18.35112 ? 130 MET A SD  1 
ATOM   1011 S SD  B MET A 1 130 ? -22.14911 -24.09880 16.45809  0.300 16.84010 ? 130 MET A SD  1 
ATOM   1012 C CE  A MET A 1 130 ? -20.56723 -25.08855 15.28413  0.700 15.10288 ? 130 MET A CE  1 
ATOM   1013 C CE  B MET A 1 130 ? -20.84943 -25.23211 15.96499  0.300 15.58926 ? 130 MET A CE  1 
ATOM   1014 N N   . ARG A 1 131 ? -19.15392 -19.83261 16.74027  1.000 16.21536 ? 131 ARG A N   1 
ATOM   1015 C CA  . ARG A 1 131 ? -19.54183 -18.42630 16.77403  1.000 18.07447 ? 131 ARG A CA  1 
ATOM   1016 C C   . ARG A 1 131 ? -21.05671 -18.30504 16.88900  1.000 15.56834 ? 131 ARG A C   1 
ATOM   1017 O O   . ARG A 1 131 ? -21.78878 -19.21523 16.50031  1.000 16.15304 ? 131 ARG A O   1 
ATOM   1018 C CB  . ARG A 1 131 ? -19.07258 -17.69863 15.52054  1.000 14.31651 ? 131 ARG A CB  1 
ATOM   1019 C CG  . ARG A 1 131 ? -17.55119 -17.64238 15.26713  1.000 11.92042 ? 131 ARG A CG  1 
ATOM   1020 C CD  . ARG A 1 131 ? -16.76934 -17.20791 16.49346  1.000 16.89812 ? 131 ARG A CD  1 
ATOM   1021 N NE  . ARG A 1 131 ? -17.30175 -15.97448 17.06396  1.000 14.64129 ? 131 ARG A NE  1 
ATOM   1022 C CZ  . ARG A 1 131 ? -16.93312 -15.52687 18.25704  1.000 16.30819 ? 131 ARG A CZ  1 
ATOM   1023 N NH1 . ARG A 1 131 ? -16.03224 -16.17329 18.97602  1.000 15.42043 ? 131 ARG A NH1 1 
ATOM   1024 N NH2 . ARG A 1 131 ? -17.50387 -14.42284 18.74610  1.000 17.75404 ? 131 ARG A NH2 1 
ATOM   1025 N N   . PRO A 1 132 ? -21.54931 -17.17286 17.40980  1.000 14.76601 ? 132 PRO A N   1 
ATOM   1026 C CA  . PRO A 1 132 ? -23.00169 -16.93809 17.39097  1.000 17.64693 ? 132 PRO A CA  1 
ATOM   1027 C C   . PRO A 1 132 ? -23.61297 -17.05767 16.01744  1.000 13.22444 ? 132 PRO A C   1 
ATOM   1028 O O   . PRO A 1 132 ? -24.78782 -17.42137 15.91983  1.000 17.71104 ? 132 PRO A O   1 
ATOM   1029 C CB  . PRO A 1 132 ? -23.12729 -15.51403 17.94746  1.000 15.84401 ? 132 PRO A CB  1 
ATOM   1030 C CG  . PRO A 1 132 ? -21.97338 -15.44747 18.93286  1.000 18.30727 ? 132 PRO A CG  1 
ATOM   1031 C CD  . PRO A 1 132 ? -20.84610 -16.18008 18.24716  1.000 18.06678 ? 132 PRO A CD  1 
ATOM   1032 N N   . ASN A 1 133 ? -22.84827 -16.80688 14.95600  1.000 16.76379 ? 133 ASN A N   1 
ATOM   1033 C CA  . ASN A 1 133 ? -23.35831 -16.95561 13.59556  1.000 13.62431 ? 133 ASN A CA  1 
ATOM   1034 C C   . ASN A 1 133 ? -23.06414 -18.33175 13.00437  1.000 19.31676 ? 133 ASN A C   1 
ATOM   1035 O O   . ASN A 1 133 ? -23.21666 -18.51504 11.79075  1.000 16.31932 ? 133 ASN A O   1 
ATOM   1036 C CB  . ASN A 1 133 ? -22.81673 -15.83460 12.69555  1.000 13.21205 ? 133 ASN A CB  1 
ATOM   1037 C CG  . ASN A 1 133 ? -21.33018 -15.97978 12.36007  1.000 17.38212 ? 133 ASN A CG  1 
ATOM   1038 O OD1 . ASN A 1 133 ? -20.64440 -16.90709 12.79069  1.000 16.44728 ? 133 ASN A OD1 1 
ATOM   1039 N ND2 . ASN A 1 133 ? -20.83937 -15.05789 11.55135  1.000 17.12165 ? 133 ASN A ND2 1 
ATOM   1040 N N   . PHE A 1 134 ? -22.66356 -19.29627 13.84090  1.000 16.23513 ? 134 PHE A N   1 
ATOM   1041 C CA  . PHE A 1 134 ? -22.54375 -20.71271 13.46680  1.000 15.96955 ? 134 PHE A CA  1 
ATOM   1042 C C   . PHE A 1 134 ? -21.41501 -20.97956 12.48622  1.000 21.35081 ? 134 PHE A C   1 
ATOM   1043 O O   . PHE A 1 134 ? -21.45291 -21.96810 11.74033  1.000 24.45665 ? 134 PHE A O   1 
ATOM   1044 C CB  . PHE A 1 134 ? -23.85829 -21.26682 12.89224  1.000 17.63724 ? 134 PHE A CB  1 
ATOM   1045 C CG  . PHE A 1 134 ? -24.95458 -21.38755 13.90728  1.000 17.50461 ? 134 PHE A CG  1 
ATOM   1046 C CD1 . PHE A 1 134 ? -24.91225 -22.36418 14.88967  1.000 20.87367 ? 134 PHE A CD1 1 
ATOM   1047 C CD2 . PHE A 1 134 ? -26.04863 -20.53301 13.86518  1.000 25.22546 ? 134 PHE A CD2 1 
ATOM   1048 C CE1 . PHE A 1 134 ? -25.92901 -22.48316 15.82789  1.000 27.71837 ? 134 PHE A CE1 1 
ATOM   1049 C CE2 . PHE A 1 134 ? -27.07471 -20.64985 14.79803  1.000 23.46433 ? 134 PHE A CE2 1 
ATOM   1050 C CZ  . PHE A 1 134 ? -27.01059 -21.62358 15.77871  1.000 27.71314 ? 134 PHE A CZ  1 
ATOM   1051 N N   . THR A 1 135 ? -20.42975 -20.10418 12.43083  1.000 16.25380 ? 135 THR A N   1 
ATOM   1052 C CA  . THR A 1 135 ? -19.16366 -20.40066 11.78744  1.000 17.68275 ? 135 THR A CA  1 
ATOM   1053 C C   . THR A 1 135 ? -18.15351 -20.74473 12.86730  1.000 18.36735 ? 135 THR A C   1 
ATOM   1054 O O   . THR A 1 135 ? -18.40404 -20.55620 14.06023  1.000 15.20804 ? 135 THR A O   1 
ATOM   1055 C CB  . THR A 1 135 ? -18.67600 -19.20288 10.97789  1.000 14.91192 ? 135 THR A CB  1 
ATOM   1056 O OG1 . THR A 1 135 ? -18.50756 -18.09130 11.87128  1.000 16.62448 ? 135 THR A OG1 1 
ATOM   1057 C CG2 . THR A 1 135 ? -19.69790 -18.84236 9.89837   1.000 15.45992 ? 135 THR A CG2 1 
ATOM   1058 N N   . ILE A 1 136 ? -17.00622 -21.26465 12.44415  1.000 15.50590 ? 136 ILE A N   1 
ATOM   1059 C CA  . ILE A 1 136 ? -15.87595 -21.35906 13.35518  1.000 15.10890 ? 136 ILE A CA  1 
ATOM   1060 C C   . ILE A 1 136 ? -14.66709 -20.74670 12.66320  1.000 15.96407 ? 136 ILE A C   1 
ATOM   1061 O O   . ILE A 1 136 ? -14.55590 -20.73936 11.43677  1.000 14.84914 ? 136 ILE A O   1 
ATOM   1062 C CB  . ILE A 1 136 ? -15.60231 -22.80929 13.83257  1.000 27.36810 ? 136 ILE A CB  1 
ATOM   1063 C CG1 . ILE A 1 136 ? -15.03533 -23.67050 12.71965  1.000 23.68040 ? 136 ILE A CG1 1 
ATOM   1064 C CG2 . ILE A 1 136 ? -16.88195 -23.45735 14.40085  1.000 22.97001 ? 136 ILE A CG2 1 
ATOM   1065 C CD1 . ILE A 1 136 ? -14.73453 -25.09399 13.17950  1.000 18.44735 ? 136 ILE A CD1 1 
ATOM   1066 N N   . LYS A 1 137 ? -13.77640 -20.18122 13.46809  1.000 17.57099 ? 137 LYS A N   1 
ATOM   1067 C CA  . LYS A 1 137 ? -12.54254 -19.58357 12.97382  1.000 22.41161 ? 137 LYS A CA  1 
ATOM   1068 C C   . LYS A 1 137 ? -11.43470 -20.59388 13.23974  1.000 22.89995 ? 137 LYS A C   1 
ATOM   1069 O O   . LYS A 1 137 ? -10.76411 -20.55836 14.27371  1.000 23.51067 ? 137 LYS A O   1 
ATOM   1070 C CB  . LYS A 1 137 ? -12.29839 -18.24824 13.66245  1.000 21.75665 ? 137 LYS A CB  1 
ATOM   1071 C CG  . LYS A 1 137 ? -13.38001 -17.22108 13.37389  1.000 26.25719 ? 137 LYS A CG  1 
ATOM   1072 C CD  . LYS A 1 137 ? -13.16643 -15.94862 14.17763  1.000 34.05795 ? 137 LYS A CD  1 
ATOM   1073 C CE  . LYS A 1 137 ? -14.28082 -14.95495 13.93160  1.000 42.48123 ? 137 LYS A CE  1 
ATOM   1074 N NZ  . LYS A 1 137 ? -14.20675 -14.38294 12.55749  1.000 53.04920 ? 137 LYS A NZ  1 
ATOM   1075 N N   . GLY A 1 138 ? -11.23910 -21.51227 12.29268  1.000 22.72859 ? 138 GLY A N   1 
ATOM   1076 C CA  . GLY A 1 138 ? -10.35987 -22.63166 12.48229  1.000 20.78628 ? 138 GLY A CA  1 
ATOM   1077 C C   . GLY A 1 138 ? -9.06913  -22.51620 11.69789  1.000 21.27409 ? 138 GLY A C   1 
ATOM   1078 O O   . GLY A 1 138 ? -8.69015  -21.44320 11.21370  1.000 25.91010 ? 138 GLY A O   1 
ATOM   1079 N N   . SER A 1 139 ? -8.39417  -23.65665 11.56727  1.000 16.37328 ? 139 SER A N   1 
ATOM   1080 C CA  . SER A 1 139 ? -7.18984  -23.81610 10.74983  1.000 18.51610 ? 139 SER A CA  1 
ATOM   1081 C C   . SER A 1 139 ? -7.41399  -25.07311 9.91102   1.000 25.56865 ? 139 SER A C   1 
ATOM   1082 O O   . SER A 1 139 ? -7.22022  -26.19555 10.39220  1.000 25.57519 ? 139 SER A O   1 
ATOM   1083 C CB  . SER A 1 139 ? -5.93409  -23.92202 11.60883  1.000 26.87213 ? 139 SER A CB  1 
ATOM   1084 O OG  . SER A 1 139 ? -4.80350  -24.22492 10.81052  1.000 32.78490 ? 139 SER A OG  1 
ATOM   1085 N N   . PHE A 1 140 ? -7.85045  -24.88505 8.66475   1.000 18.95816 ? 140 PHE A N   1 
ATOM   1086 C CA  . PHE A 1 140 ? -8.29870  -25.99569 7.82052   1.000 25.27018 ? 140 PHE A CA  1 
ATOM   1087 C C   . PHE A 1 140 ? -7.76712  -25.77701 6.41073   1.000 32.58176 ? 140 PHE A C   1 
ATOM   1088 O O   . PHE A 1 140 ? -8.23721  -24.87834 5.70784   1.000 32.46716 ? 140 PHE A O   1 
ATOM   1089 C CB  . PHE A 1 140 ? -9.82748  -26.10373 7.76984   1.000 21.72530 ? 140 PHE A CB  1 
ATOM   1090 C CG  . PHE A 1 140 ? -10.48528 -26.52031 9.05954   1.000 17.30431 ? 140 PHE A CG  1 
ATOM   1091 C CD1 . PHE A 1 140 ? -10.46618 -27.83900 9.47912   1.000 21.25761 ? 140 PHE A CD1 1 
ATOM   1092 C CD2 . PHE A 1 140 ? -11.19477 -25.60887 9.81219   1.000 18.23115 ? 140 PHE A CD2 1 
ATOM   1093 C CE1 . PHE A 1 140 ? -11.11302 -28.22033 10.65520  1.000 21.32711 ? 140 PHE A CE1 1 
ATOM   1094 C CE2 . PHE A 1 140 ? -11.84171 -25.97754 10.98488  1.000 17.23475 ? 140 PHE A CE2 1 
ATOM   1095 C CZ  . PHE A 1 140 ? -11.80847 -27.28747 11.40390  1.000 25.23846 ? 140 PHE A CZ  1 
ATOM   1096 N N   . LEU A 1 141 ? -6.81623  -26.60275 5.99062   1.000 25.21086 ? 141 LEU A N   1 
ATOM   1097 C CA  . LEU A 1 141 ? -6.30195  -26.57687 4.63365   1.000 28.84467 ? 141 LEU A CA  1 
ATOM   1098 C C   . LEU A 1 141 ? -7.05073  -27.59699 3.78632   1.000 30.06486 ? 141 LEU A C   1 
ATOM   1099 O O   . LEU A 1 141 ? -7.89598  -28.34712 4.28182   1.000 22.16501 ? 141 LEU A O   1 
ATOM   1100 C CB  . LEU A 1 141 ? -4.80374  -26.86819 4.61965   1.000 30.46970 ? 141 LEU A CB  1 
ATOM   1101 C CG  . LEU A 1 141 ? -3.88607  -25.91768 5.37964   1.000 42.43006 ? 141 LEU A CG  1 
ATOM   1102 C CD1 . LEU A 1 141 ? -2.48885  -26.50630 5.40108   1.000 45.88664 ? 141 LEU A CD1 1 
ATOM   1103 C CD2 . LEU A 1 141 ? -3.88398  -24.54028 4.73283   1.000 37.58592 ? 141 LEU A CD2 1 
ATOM   1104 N N   . ASN A 1 142 ? -6.72802  -27.62914 2.49179   1.000 33.87234 ? 142 ASN A N   1 
ATOM   1105 C CA  . ASN A 1 142 ? -7.31092  -28.61204 1.58699   1.000 35.21989 ? 142 ASN A CA  1 
ATOM   1106 C C   . ASN A 1 142 ? -7.07821  -30.02068 2.12170   1.000 27.85251 ? 142 ASN A C   1 
ATOM   1107 O O   . ASN A 1 142 ? -5.97349  -30.35969 2.56374   1.000 28.66414 ? 142 ASN A O   1 
ATOM   1108 C CB  . ASN A 1 142 ? -6.69729  -28.46410 0.19210   1.000 30.94486 ? 142 ASN A CB  1 
ATOM   1109 C CG  . ASN A 1 142 ? -7.55035  -29.08881 -0.89196  1.000 60.20393 ? 142 ASN A CG  1 
ATOM   1110 O OD1 . ASN A 1 142 ? -7.73326  -30.30748 -0.93585  1.000 58.94266 ? 142 ASN A OD1 1 
ATOM   1111 N ND2 . ASN A 1 142 ? -8.06579  -28.25358 -1.78842  1.000 75.14842 ? 142 ASN A ND2 1 
ATOM   1112 N N   . GLY A 1 143 ? -8.13149  -30.83471 2.10584   1.000 27.09395 ? 143 GLY A N   1 
ATOM   1113 C CA  . GLY A 1 143 ? -8.02540  -32.18376 2.61086   1.000 25.26232 ? 143 GLY A CA  1 
ATOM   1114 C C   . GLY A 1 143 ? -8.36013  -32.35060 4.07406   1.000 26.51757 ? 143 GLY A C   1 
ATOM   1115 O O   . GLY A 1 143 ? -8.39150  -33.48634 4.55661   1.000 21.81101 ? 143 GLY A O   1 
ATOM   1116 N N   . SER A 1 144 ? -8.61300  -31.26314 4.79674   1.000 24.22534 ? 144 SER A N   1 
ATOM   1117 C CA  . SER A 1 144 ? -9.00409  -31.36787 6.19711   1.000 21.12295 ? 144 SER A CA  1 
ATOM   1118 C C   . SER A 1 144 ? -10.47771 -31.70408 6.37205   1.000 18.38946 ? 144 SER A C   1 
ATOM   1119 O O   . SER A 1 144 ? -10.91110 -31.90170 7.51034   1.000 17.20807 ? 144 SER A O   1 
ATOM   1120 C CB  . SER A 1 144 ? -8.70026  -30.05937 6.93416   1.000 18.95061 ? 144 SER A CB  1 
ATOM   1121 O OG  . SER A 1 144 ? -9.46477  -28.99712 6.38109   1.000 20.78905 ? 144 SER A OG  1 
ATOM   1122 N N   . CYS A 1 145 ? -11.25504 -31.76201 5.28245   1.000 17.62444 ? 145 CYS A N   1 
ATOM   1123 C CA  . CYS A 1 145 ? -12.67103 -32.05849 5.43197   1.000 16.68854 ? 145 CYS A CA  1 
ATOM   1124 C C   . CYS A 1 145 ? -12.84953 -33.42017 6.08711   1.000 19.43187 ? 145 CYS A C   1 
ATOM   1125 O O   . CYS A 1 145 ? -12.08591 -34.35558 5.83202   1.000 18.82153 ? 145 CYS A O   1 
ATOM   1126 C CB  . CYS A 1 145 ? -13.38643 -32.01962 4.07900   1.000 20.08473 ? 145 CYS A CB  1 
ATOM   1127 S SG  . CYS A 1 145 ? -13.30719 -30.39918 3.31749   1.000 26.91938 ? 145 CYS A SG  1 
ATOM   1128 N N   . GLY A 1 146 ? -13.87736 -33.53298 6.92759   1.000 15.38118 ? 146 GLY A N   1 
ATOM   1129 C CA  . GLY A 1 146 ? -14.07028 -34.71891 7.72302   1.000 12.23846 ? 146 GLY A CA  1 
ATOM   1130 C C   . GLY A 1 146 ? -13.36454 -34.71192 9.06476   1.000 14.80414 ? 146 GLY A C   1 
ATOM   1131 O O   . GLY A 1 146 ? -13.65812 -35.57139 9.89220   1.000 16.60462 ? 146 GLY A O   1 
ATOM   1132 N N   . SER A 1 147 ? -12.43347 -33.78198 9.30117   1.000 12.81010 ? 147 SER A N   1 
ATOM   1133 C CA  . SER A 1 147 ? -11.90758 -33.57994 10.64904  1.000 11.87654 ? 147 SER A CA  1 
ATOM   1134 C C   . SER A 1 147 ? -13.05776 -33.23637 11.58460  1.000 13.04926 ? 147 SER A C   1 
ATOM   1135 O O   . SER A 1 147 ? -14.01095 -32.56307 11.18560  1.000 14.50779 ? 147 SER A O   1 
ATOM   1136 C CB  . SER A 1 147 ? -10.89381 -32.43563 10.65934  1.000 16.06269 ? 147 SER A CB  1 
ATOM   1137 O OG  . SER A 1 147 ? -9.75618  -32.75757 9.88773   1.000 16.71908 ? 147 SER A OG  1 
ATOM   1138 N N   . VAL A 1 148 ? -12.95345 -33.65472 12.85011  1.000 14.30261 ? 148 VAL A N   1 
ATOM   1139 C CA  . VAL A 1 148 ? -14.09901 -33.55102 13.73862  1.000 12.07187 ? 148 VAL A CA  1 
ATOM   1140 C C   . VAL A 1 148 ? -13.78831 -32.70028 14.96622  1.000 14.52746 ? 148 VAL A C   1 
ATOM   1141 O O   . VAL A 1 148 ? -12.63412 -32.51178 15.37449  1.000 15.21340 ? 148 VAL A O   1 
ATOM   1142 C CB  . VAL A 1 148 ? -14.64000 -34.93361 14.14850  1.000 14.42467 ? 148 VAL A CB  1 
ATOM   1143 C CG1 . VAL A 1 148 ? -15.02909 -35.72544 12.91784  1.000 14.25313 ? 148 VAL A CG1 1 
ATOM   1144 C CG2 . VAL A 1 148 ? -13.61954 -35.69051 14.98867  1.000 18.40609 ? 148 VAL A CG2 1 
ATOM   1145 N N   . GLY A 1 149 ? -14.85916 -32.12691 15.52151  1.000 11.61687 ? 149 GLY A N   1 
ATOM   1146 C CA  . GLY A 1 149 ? -14.80377 -31.41048 16.78791  1.000 12.11774 ? 149 GLY A CA  1 
ATOM   1147 C C   . GLY A 1 149 ? -15.51150 -32.20037 17.87260  1.000 14.19908 ? 149 GLY A C   1 
ATOM   1148 O O   . GLY A 1 149 ? -16.44109 -32.95826 17.59803  1.000 15.19913 ? 149 GLY A O   1 
ATOM   1149 N N   . PHE A 1 150 ? -15.06808 -32.01882 19.11668  1.000 14.49753 ? 150 PHE A N   1 
ATOM   1150 C CA  . PHE A 1 150 ? -15.53338 -32.88984 20.18384  1.000 13.51858 ? 150 PHE A CA  1 
ATOM   1151 C C   . PHE A 1 150 ? -15.22927 -32.26412 21.53323  1.000 16.54575 ? 150 PHE A C   1 
ATOM   1152 O O   . PHE A 1 150 ? -14.35144 -31.40171 21.66093  1.000 16.08048 ? 150 PHE A O   1 
ATOM   1153 C CB  . PHE A 1 150 ? -14.87132 -34.27362 20.10520  1.000 12.88026 ? 150 PHE A CB  1 
ATOM   1154 C CG  . PHE A 1 150 ? -13.37199 -34.22581 20.26682  1.000 13.35389 ? 150 PHE A CG  1 
ATOM   1155 C CD1 . PHE A 1 150 ? -12.55012 -33.92466 19.19320  1.000 16.89976 ? 150 PHE A CD1 1 
ATOM   1156 C CD2 . PHE A 1 150 ? -12.79350 -34.45274 21.51862  1.000 15.02919 ? 150 PHE A CD2 1 
ATOM   1157 C CE1 . PHE A 1 150 ? -11.16955 -33.84229 19.34998  1.000 19.17890 ? 150 PHE A CE1 1 
ATOM   1158 C CE2 . PHE A 1 150 ? -11.42545 -34.39043 21.68309  1.000 19.22355 ? 150 PHE A CE2 1 
ATOM   1159 C CZ  . PHE A 1 150 ? -10.60623 -34.07080 20.60477  1.000 18.81400 ? 150 PHE A CZ  1 
ATOM   1160 N N   . ASN A 1 151 ? -15.97638 -32.73098 22.52613  1.000 14.63435 ? 151 ASN A N   1 
ATOM   1161 C CA  . ASN A 1 151 ? -15.70669 -32.54685 23.94591  1.000 16.52915 ? 151 ASN A CA  1 
ATOM   1162 C C   . ASN A 1 151 ? -15.54788 -33.90933 24.61012  1.000 15.84125 ? 151 ASN A C   1 
ATOM   1163 O O   . ASN A 1 151 ? -16.05110 -34.92230 24.12310  1.000 17.00907 ? 151 ASN A O   1 
ATOM   1164 C CB  . ASN A 1 151 ? -16.84306 -31.77448 24.61463  1.000 20.35418 ? 151 ASN A CB  1 
ATOM   1165 C CG  . ASN A 1 151 ? -16.81623 -30.30724 24.27998  1.000 22.08770 ? 151 ASN A CG  1 
ATOM   1166 O OD1 . ASN A 1 151 ? -16.16148 -29.52575 24.97404  1.000 30.04357 ? 151 ASN A OD1 1 
ATOM   1167 N ND2 . ASN A 1 151 ? -17.50760 -29.91691 23.21325  1.000 18.68967 ? 151 ASN A ND2 1 
ATOM   1168 N N   . ILE A 1 152 ? -14.86897 -33.94212 25.75592  1.000 18.15361 ? 152 ILE A N   1 
ATOM   1169 C CA  . ILE A 1 152 ? -14.71787 -35.19424 26.48693  1.000 21.85226 ? 152 ILE A CA  1 
ATOM   1170 C C   . ILE A 1 152 ? -15.20485 -34.99228 27.91495  1.000 32.99502 ? 152 ILE A C   1 
ATOM   1171 O O   . ILE A 1 152 ? -14.83394 -34.01145 28.56538  1.000 31.34444 ? 152 ILE A O   1 
ATOM   1172 C CB  . ILE A 1 152 ? -13.26848 -35.71261 26.48243  1.000 22.72585 ? 152 ILE A CB  1 
ATOM   1173 C CG1 . ILE A 1 152 ? -12.69075 -35.71132 25.07078  1.000 25.59057 ? 152 ILE A CG1 1 
ATOM   1174 C CG2 . ILE A 1 152 ? -13.23387 -37.12172 27.04431  1.000 29.92600 ? 152 ILE A CG2 1 
ATOM   1175 C CD1 . ILE A 1 152 ? -11.35232 -36.40313 24.97787  1.000 34.94079 ? 152 ILE A CD1 1 
ATOM   1176 N N   . ASP A 1 153 ? -16.04551 -35.91339 28.38966  1.000 40.52212 ? 153 ASP A N   1 
ATOM   1177 C CA  . ASP A 1 153 ? -16.54830 -35.93472 29.76202  1.000 35.06236 ? 153 ASP A CA  1 
ATOM   1178 C C   . ASP A 1 153 ? -16.17124 -37.28293 30.36432  1.000 30.65978 ? 153 ASP A C   1 
ATOM   1179 O O   . ASP A 1 153 ? -16.77463 -38.30731 30.02827  1.000 45.19043 ? 153 ASP A O   1 
ATOM   1180 C CB  . ASP A 1 153 ? -18.06139 -35.70897 29.79688  1.000 38.30202 ? 153 ASP A CB  1 
ATOM   1181 C CG  . ASP A 1 153 ? -18.65970 -35.89177 31.19024  1.000 64.26733 ? 153 ASP A CG  1 
ATOM   1182 O OD1 . ASP A 1 153 ? -17.90161 -36.01358 32.17765  1.000 54.94318 ? 153 ASP A OD1 1 
ATOM   1183 O OD2 . ASP A 1 153 ? -19.90573 -35.91339 31.29814  1.000 72.79997 ? 153 ASP A OD2 1 
ATOM   1184 N N   . TYR A 1 154 ? -15.18453 -37.27377 31.26239  1.000 37.79766 ? 154 TYR A N   1 
ATOM   1185 C CA  . TYR A 1 154 ? -14.62739 -38.49421 31.83198  1.000 50.98535 ? 154 TYR A CA  1 
ATOM   1186 C C   . TYR A 1 154 ? -14.11221 -39.40741 30.72565  1.000 32.40894 ? 154 TYR A C   1 
ATOM   1187 O O   . TYR A 1 154 ? -13.04486 -39.15867 30.15556  1.000 54.68131 ? 154 TYR A O   1 
ATOM   1188 C CB  . TYR A 1 154 ? -15.66450 -39.21423 32.69954  1.000 49.75405 ? 154 TYR A CB  1 
ATOM   1189 N N   . ASP A 1 155 ? -14.85771 -40.46434 30.40767  1.000 34.03028 ? 155 ASP A N   1 
ATOM   1190 C CA  . ASP A 1 155 ? -14.43055 -41.41416 29.39119  1.000 52.41141 ? 155 ASP A CA  1 
ATOM   1191 C C   . ASP A 1 155 ? -15.30468 -41.36576 28.14385  1.000 33.24104 ? 155 ASP A C   1 
ATOM   1192 O O   . ASP A 1 155 ? -15.15440 -42.21716 27.26266  1.000 35.58079 ? 155 ASP A O   1 
ATOM   1193 C CB  . ASP A 1 155 ? -14.39225 -42.83361 29.97172  1.000 45.63260 ? 155 ASP A CB  1 
ATOM   1194 C CG  . ASP A 1 155 ? -15.74830 -43.30956 30.47950  1.000 43.75777 ? 155 ASP A CG  1 
ATOM   1195 O OD1 . ASP A 1 155 ? -16.66198 -42.47349 30.65668  1.000 39.23646 ? 155 ASP A OD1 1 
ATOM   1196 O OD2 . ASP A 1 155 ? -15.89119 -44.53419 30.71693  1.000 46.68482 ? 155 ASP A OD2 1 
ATOM   1197 N N   . CYS A 1 156 ? -16.19335 -40.38180 28.03651  1.000 26.72121 ? 156 CYS A N   1 
ATOM   1198 C CA  . CYS A 1 156 ? -17.14370 -40.31331 26.93256  1.000 23.45882 ? 156 CYS A CA  1 
ATOM   1199 C C   . CYS A 1 156 ? -16.80550 -39.14886 26.01040  1.000 24.76786 ? 156 CYS A C   1 
ATOM   1200 O O   . CYS A 1 156 ? -16.73977 -37.99403 26.44759  1.000 23.77947 ? 156 CYS A O   1 
ATOM   1201 C CB  . CYS A 1 156 ? -18.57653 -40.17540 27.44621  1.000 27.89569 ? 156 CYS A CB  1 
ATOM   1202 S SG  . CYS A 1 156 ? -19.80800 -40.09882 26.12032  1.000 32.27822 ? 156 CYS A SG  1 
ATOM   1203 N N   . VAL A 1 157 ? -16.64748 -39.45231 24.72578  1.000 24.02808 ? 157 VAL A N   1 
ATOM   1204 C CA  . VAL A 1 157 ? -16.38033 -38.43790 23.71733  1.000 19.02801 ? 157 VAL A CA  1 
ATOM   1205 C C   . VAL A 1 157 ? -17.70606 -38.00054 23.12267  1.000 17.36932 ? 157 VAL A C   1 
ATOM   1206 O O   . VAL A 1 157 ? -18.43883 -38.81761 22.56015  1.000 19.03120 ? 157 VAL A O   1 
ATOM   1207 C CB  . VAL A 1 157 ? -15.44645 -38.96648 22.61862  1.000 19.28380 ? 157 VAL A CB  1 
ATOM   1208 C CG1 . VAL A 1 157 ? -15.24417 -37.88406 21.55580  1.000 20.74395 ? 157 VAL A CG1 1 
ATOM   1209 C CG2 . VAL A 1 157 ? -14.10981 -39.42211 23.21295  1.000 18.18131 ? 157 VAL A CG2 1 
ATOM   1210 N N   . SER A 1 158 ? -18.01411 -36.71483 23.23984  1.000 19.77826 ? 158 SER A N   1 
ATOM   1211 C CA  . SER A 1 158 ? -19.20357 -36.13610 22.61714  1.000 20.64484 ? 158 SER A CA  1 
ATOM   1212 C C   . SER A 1 158 ? -18.74659 -35.44612 21.33859  1.000 14.21897 ? 158 SER A C   1 
ATOM   1213 O O   . SER A 1 158 ? -18.16704 -34.36001 21.37992  1.000 16.85256 ? 158 SER A O   1 
ATOM   1214 C CB  . SER A 1 158 ? -19.89994 -35.16281 23.56172  1.000 23.79005 ? 158 SER A CB  1 
ATOM   1215 O OG  . SER A 1 158 ? -20.62638 -35.85697 24.56537  1.000 25.54478 ? 158 SER A OG  1 
ATOM   1216 N N   . PHE A 1 159 ? -18.99679 -36.09298 20.20583  1.000 17.81864 ? 159 PHE A N   1 
ATOM   1217 C CA  . PHE A 1 159 ? -18.68722 -35.50496 18.90762  1.000 16.53673 ? 159 PHE A CA  1 
ATOM   1218 C C   . PHE A 1 159 ? -19.75433 -34.47721 18.55870  1.000 16.31411 ? 159 PHE A C   1 
ATOM   1219 O O   . PHE A 1 159 ? -20.95959 -34.74945 18.66708  1.000 17.92721 ? 159 PHE A O   1 
ATOM   1220 C CB  . PHE A 1 159 ? -18.61744 -36.58872 17.82953  1.000 16.47742 ? 159 PHE A CB  1 
ATOM   1221 C CG  . PHE A 1 159 ? -17.48524 -37.55898 18.01223  1.000 14.36116 ? 159 PHE A CG  1 
ATOM   1222 C CD1 . PHE A 1 159 ? -16.19297 -37.22210 17.62715  1.000 15.42321 ? 159 PHE A CD1 1 
ATOM   1223 C CD2 . PHE A 1 159 ? -17.71638 -38.82440 18.53679  1.000 17.99004 ? 159 PHE A CD2 1 
ATOM   1224 C CE1 . PHE A 1 159 ? -15.14649 -38.11839 17.77522  1.000 15.61744 ? 159 PHE A CE1 1 
ATOM   1225 C CE2 . PHE A 1 159 ? -16.67816 -39.72451 18.69507  1.000 16.09121 ? 159 PHE A CE2 1 
ATOM   1226 C CZ  . PHE A 1 159 ? -15.38350 -39.36631 18.32299  1.000 15.50993 ? 159 PHE A CZ  1 
ATOM   1227 N N   . CYS A 1 160 ? -19.31827 -33.28190 18.17639  1.000 14.24736 ? 160 CYS A N   1 
ATOM   1228 C CA  . CYS A 1 160 ? -20.26786 -32.23128 17.87029  1.000 13.18800 ? 160 CYS A CA  1 
ATOM   1229 C C   . CYS A 1 160 ? -20.08165 -31.58751 16.50669  1.000 11.00687 ? 160 CYS A C   1 
ATOM   1230 O O   . CYS A 1 160 ? -20.96836 -30.84187 16.08390  1.000 16.14920 ? 160 CYS A O   1 
ATOM   1231 C CB  . CYS A 1 160 ? -20.22635 -31.12982 18.94913  1.000 17.67406 ? 160 CYS A CB  1 
ATOM   1232 S SG  . CYS A 1 160 ? -18.61687 -30.32976 19.16919  1.000 16.34011 ? 160 CYS A SG  1 
ATOM   1233 N N   . TYR A 1 161 ? -18.96484 -31.81008 15.81930  1.000 12.71340 ? 161 TYR A N   1 
ATOM   1234 C CA  . TYR A 1 161 ? -18.68138 -31.05431 14.60739  1.000 15.54338 ? 161 TYR A CA  1 
ATOM   1235 C C   . TYR A 1 161 ? -17.92931 -31.93380 13.62790  1.000 13.29116 ? 161 TYR A C   1 
ATOM   1236 O O   . TYR A 1 161 ? -17.05206 -32.70262 14.02973  1.000 13.22559 ? 161 TYR A O   1 
ATOM   1237 C CB  . TYR A 1 161 ? -17.84728 -29.78714 14.91606  1.000 13.29024 ? 161 TYR A CB  1 
ATOM   1238 C CG  . TYR A 1 161 ? -17.51517 -28.93798 13.68742  1.000 11.69047 ? 161 TYR A CG  1 
ATOM   1239 C CD1 . TYR A 1 161 ? -18.42848 -28.01732 13.18285  1.000 15.09613 ? 161 TYR A CD1 1 
ATOM   1240 C CD2 . TYR A 1 161 ? -16.26449 -29.02449 13.06814  1.000 12.50248 ? 161 TYR A CD2 1 
ATOM   1241 C CE1 . TYR A 1 161 ? -18.11975 -27.24029 12.05593  1.000 13.95106 ? 161 TYR A CE1 1 
ATOM   1242 C CE2 . TYR A 1 161 ? -15.94509 -28.24546 11.96652  1.000 14.16940 ? 161 TYR A CE2 1 
ATOM   1243 C CZ  . TYR A 1 161 ? -16.87319 -27.35932 11.46266  1.000 11.55965 ? 161 TYR A CZ  1 
ATOM   1244 O OH  . TYR A 1 161 ? -16.54548 -26.59191 10.35103  1.000 16.86417 ? 161 TYR A OH  1 
ATOM   1245 N N   . MET A 1 162 ? -18.30275 -31.82892 12.35131  1.000 11.94978 ? 162 MET A N   1 
ATOM   1246 C CA  . MET A 1 162 ? -17.50842 -32.34590 11.23772  1.000 14.24765 ? 162 MET A CA  1 
ATOM   1247 C C   . MET A 1 162 ? -17.27489 -31.22182 10.23322  1.000 15.50506 ? 162 MET A C   1 
ATOM   1248 O O   . MET A 1 162 ? -18.21420 -30.50683 9.86054   1.000 13.20372 ? 162 MET A O   1 
ATOM   1249 C CB  . MET A 1 162 ? -18.19265 -33.53381 10.53477  1.000 14.76984 ? 162 MET A CB  1 
ATOM   1250 C CG  . MET A 1 162 ? -17.33916 -34.11417 9.43035   1.000 14.35643 ? 162 MET A CG  1 
ATOM   1251 S SD  . MET A 1 162 ? -17.89136 -35.71462 8.81563   1.000 19.59343 ? 162 MET A SD  1 
ATOM   1252 C CE  . MET A 1 162 ? -17.07294 -36.79580 10.00459  1.000 18.95354 ? 162 MET A CE  1 
ATOM   1253 N N   . HIS A 1 163 ? -16.02265 -31.04912 9.81344   1.000 15.03250 ? 163 HIS A N   1 
ATOM   1254 C CA  . HIS A 1 163 ? -15.68192 -29.93591 8.94050   1.000 15.43303 ? 163 HIS A CA  1 
ATOM   1255 C C   . HIS A 1 163 ? -16.06203 -30.23356 7.49333   1.000 13.42513 ? 163 HIS A C   1 
ATOM   1256 O O   . HIS A 1 163 ? -15.73664 -31.30638 6.96809   1.000 15.65918 ? 163 HIS A O   1 
ATOM   1257 C CB  . HIS A 1 163 ? -14.18689 -29.65734 9.00453   1.000 15.50440 ? 163 HIS A CB  1 
ATOM   1258 C CG  . HIS A 1 163 ? -13.79515 -28.49285 8.16821   1.000 16.06930 ? 163 HIS A CG  1 
ATOM   1259 N ND1 . HIS A 1 163 ? -14.38816 -27.25569 8.31720   1.000 18.60982 ? 163 HIS A ND1 1 
ATOM   1260 C CD2 . HIS A 1 163 ? -12.91288 -28.37502 7.15087   1.000 15.70974 ? 163 HIS A CD2 1 
ATOM   1261 C CE1 . HIS A 1 163 ? -13.87676 -26.42319 7.43055   1.000 18.81708 ? 163 HIS A CE1 1 
ATOM   1262 N NE2 . HIS A 1 163 ? -12.97958 -27.07357 6.71279   1.000 15.11149 ? 163 HIS A NE2 1 
ATOM   1263 N N   . HIS A 1 164 ? -16.72846 -29.27476 6.84060   1.000 12.63132 ? 164 HIS A N   1 
ATOM   1264 C CA  . HIS A 1 164 ? -17.13326 -29.44509 5.43442   1.000 13.03370 ? 164 HIS A CA  1 
ATOM   1265 C C   . HIS A 1 164 ? -16.60845 -28.37677 4.49213   1.000 19.11429 ? 164 HIS A C   1 
ATOM   1266 O O   . HIS A 1 164 ? -16.27915 -28.68829 3.34259   1.000 20.71679 ? 164 HIS A O   1 
ATOM   1267 C CB  . HIS A 1 164 ? -18.67206 -29.46281 5.28532   1.000 11.46668 ? 164 HIS A CB  1 
ATOM   1268 C CG  . HIS A 1 164 ? -19.31884 -30.71582 5.79966   1.000 15.26993 ? 164 HIS A CG  1 
ATOM   1269 N ND1 . HIS A 1 164 ? -20.00490 -31.59210 4.98587   1.000 14.73769 ? 164 HIS A ND1 1 
ATOM   1270 C CD2 . HIS A 1 164 ? -19.41423 -31.21407 7.05437   1.000 13.74190 ? 164 HIS A CD2 1 
ATOM   1271 C CE1 . HIS A 1 164 ? -20.47483 -32.59039 5.71552   1.000 13.56888 ? 164 HIS A CE1 1 
ATOM   1272 N NE2 . HIS A 1 164 ? -20.13235 -32.38550 6.97362   1.000 14.26015 ? 164 HIS A NE2 1 
ATOM   1273 N N   . MET A 1 165 ? -16.58581 -27.11047 4.90342   1.000 18.47977 ? 165 MET A N   1 
ATOM   1274 C CA  . MET A 1 165 ? -16.42717 -26.02944 3.93691   1.000 19.10443 ? 165 MET A CA  1 
ATOM   1275 C C   . MET A 1 165 ? -15.58627 -24.90335 4.50129   1.000 12.85855 ? 165 MET A C   1 
ATOM   1276 O O   . MET A 1 165 ? -15.67587 -24.57296 5.69262   1.000 14.09810 ? 165 MET A O   1 
ATOM   1277 C CB  . MET A 1 165 ? -17.77603 -25.40342 3.50991   1.000 16.43941 ? 165 MET A CB  1 
ATOM   1278 C CG  . MET A 1 165 ? -18.86823 -26.37963 3.11652   1.000 26.76528 ? 165 MET A CG  1 
ATOM   1279 S SD  . MET A 1 165 ? -18.53593 -27.12658 1.50634   1.000 30.46722 ? 165 MET A SD  1 
ATOM   1280 C CE  . MET A 1 165 ? -18.76294 -25.70320 0.42365   1.000 37.56481 ? 165 MET A CE  1 
ATOM   1281 N N   . GLU A 1 166 ? -14.80921 -24.28205 3.62244   1.000 17.25973 ? 166 GLU A N   1 
ATOM   1282 C CA  . GLU A 1 166 ? -14.27355 -22.95252 3.87366   1.000 15.04089 ? 166 GLU A CA  1 
ATOM   1283 C C   . GLU A 1 166 ? -15.05967 -21.95461 3.03663   1.000 20.57848 ? 166 GLU A C   1 
ATOM   1284 O O   . GLU A 1 166 ? -15.16099 -22.10688 1.81581   1.000 20.99568 ? 166 GLU A O   1 
ATOM   1285 C CB  . GLU A 1 166 ? -12.78550 -22.89696 3.54236   1.000 17.71230 ? 166 GLU A CB  1 
ATOM   1286 C CG  . GLU A 1 166 ? -12.15134 -21.56644 3.89051   1.000 20.32031 ? 166 GLU A CG  1 
ATOM   1287 C CD  . GLU A 1 166 ? -10.64817 -21.63008 3.81360   1.000 30.71257 ? 166 GLU A CD  1 
ATOM   1288 O OE1 . GLU A 1 166 ? -10.09929 -21.54197 2.69514   1.000 35.92394 ? 166 GLU A OE1 1 
ATOM   1289 O OE2 . GLU A 1 166 ? -10.02079 -21.81089 4.87463   1.000 26.90287 ? 166 GLU A OE2 1 
ATOM   1290 N N   . LEU A 1 167 ? -15.63957 -20.95857 3.69554   1.000 20.32231 ? 167 LEU A N   1 
ATOM   1291 C CA  . LEU A 1 167 ? -16.36895 -19.93201 2.98608   1.000 24.93536 ? 167 LEU A CA  1 
ATOM   1292 C C   . LEU A 1 167 ? -15.38395 -19.02099 2.26537   1.000 22.99121 ? 167 LEU A C   1 
ATOM   1293 O O   . LEU A 1 167 ? -14.21183 -18.95156 2.63045   1.000 19.49431 ? 167 LEU A O   1 
ATOM   1294 C CB  . LEU A 1 167 ? -17.23545 -19.14656 3.96193   1.000 25.38394 ? 167 LEU A CB  1 
ATOM   1295 C CG  . LEU A 1 167 ? -18.19676 -20.04802 4.73100   1.000 23.41912 ? 167 LEU A CG  1 
ATOM   1296 C CD1 . LEU A 1 167 ? -19.07011 -19.21929 5.64023   1.000 27.70792 ? 167 LEU A CD1 1 
ATOM   1297 C CD2 . LEU A 1 167 ? -19.05612 -20.85976 3.75427   1.000 24.74759 ? 167 LEU A CD2 1 
ATOM   1298 N N   . PRO A 1 168 ? -15.82802 -18.33890 1.20559   1.000 25.03041 ? 168 PRO A N   1 
ATOM   1299 C CA  . PRO A 1 168 ? -14.94028 -17.38270 0.52915   1.000 24.36443 ? 168 PRO A CA  1 
ATOM   1300 C C   . PRO A 1 168 ? -14.36522 -16.33618 1.46773   1.000 24.23382 ? 168 PRO A C   1 
ATOM   1301 O O   . PRO A 1 168 ? -13.31751 -15.75220 1.16306   1.000 28.77100 ? 168 PRO A O   1 
ATOM   1302 C CB  . PRO A 1 168 ? -15.85263 -16.74904 -0.52749  1.000 26.57241 ? 168 PRO A CB  1 
ATOM   1303 C CG  . PRO A 1 168 ? -16.86795 -17.78526 -0.80242  1.000 29.24849 ? 168 PRO A CG  1 
ATOM   1304 C CD  . PRO A 1 168 ? -17.10573 -18.51208 0.49344   1.000 29.95923 ? 168 PRO A CD  1 
ATOM   1305 N N   . THR A 1 169 ? -15.01101 -16.08211 2.60335   1.000 24.93859 ? 169 THR A N   1 
ATOM   1306 C CA  . THR A 1 169 ? -14.47428 -15.15872 3.59644   1.000 18.62841 ? 169 THR A CA  1 
ATOM   1307 C C   . THR A 1 169 ? -13.40984 -15.77585 4.48998   1.000 25.98013 ? 169 THR A C   1 
ATOM   1308 O O   . THR A 1 169 ? -12.88161 -15.08155 5.36094   1.000 27.26911 ? 169 THR A O   1 
ATOM   1309 C CB  . THR A 1 169 ? -15.60336 -14.60712 4.46534   1.000 32.02803 ? 169 THR A CB  1 
ATOM   1310 O OG1 . THR A 1 169 ? -16.25051 -15.68821 5.15236   1.000 32.75996 ? 169 THR A OG1 1 
ATOM   1311 C CG2 . THR A 1 169 ? -16.62164 -13.84967 3.59712   1.000 25.45405 ? 169 THR A CG2 1 
ATOM   1312 N N   . GLY A 1 170 ? -13.07655 -17.04421 4.30862   1.000 20.16701 ? 170 GLY A N   1 
ATOM   1313 C CA  . GLY A 1 170 ? -12.00990 -17.63797 5.09032   1.000 23.91626 ? 170 GLY A CA  1 
ATOM   1314 C C   . GLY A 1 170 ? -12.42240 -18.24221 6.41865   1.000 24.28667 ? 170 GLY A C   1 
ATOM   1315 O O   . GLY A 1 170 ? -11.56581 -18.79303 7.11682   1.000 29.02654 ? 170 GLY A O   1 
ATOM   1316 N N   . VAL A 1 171 ? -13.69507 -18.17013 6.79023   1.000 21.45515 ? 171 VAL A N   1 
ATOM   1317 C CA  . VAL A 1 171 ? -14.18598 -18.84002 7.97650   1.000 21.09907 ? 171 VAL A CA  1 
ATOM   1318 C C   . VAL A 1 171 ? -14.73784 -20.20382 7.57526   1.000 21.63805 ? 171 VAL A C   1 
ATOM   1319 O O   . VAL A 1 171 ? -14.90286 -20.51170 6.39294   1.000 19.43560 ? 171 VAL A O   1 
ATOM   1320 C CB  . VAL A 1 171 ? -15.24561 -17.99386 8.72083   1.000 22.75861 ? 171 VAL A CB  1 
ATOM   1321 C CG1 . VAL A 1 171 ? -14.66081 -16.64447 9.08984   1.000 30.36502 ? 171 VAL A CG1 1 
ATOM   1322 C CG2 . VAL A 1 171 ? -16.47817 -17.82244 7.87207   1.000 24.63389 ? 171 VAL A CG2 1 
ATOM   1323 N N   . HIS A 1 172 ? -15.07285 -21.01540 8.57292   1.000 17.32278 ? 172 HIS A N   1 
ATOM   1324 C CA  . HIS A 1 172 ? -15.29427 -22.43427 8.35975   1.000 12.39222 ? 172 HIS A CA  1 
ATOM   1325 C C   . HIS A 1 172 ? -16.69892 -22.84759 8.76427   1.000 15.66141 ? 172 HIS A C   1 
ATOM   1326 O O   . HIS A 1 172 ? -17.28695 -22.30508 9.69696   1.000 14.68759 ? 172 HIS A O   1 
ATOM   1327 C CB  . HIS A 1 172 ? -14.22466 -23.21654 9.11998   1.000 14.66799 ? 172 HIS A CB  1 
ATOM   1328 C CG  . HIS A 1 172 ? -12.84999 -22.86019 8.66040   1.000 16.96791 ? 172 HIS A CG  1 
ATOM   1329 N ND1 . HIS A 1 172 ? -11.91948 -22.23213 9.46785   1.000 16.85072 ? 172 HIS A ND1 1 
ATOM   1330 C CD2 . HIS A 1 172 ? -12.28980 -22.93769 7.42903   1.000 20.43129 ? 172 HIS A CD2 1 
ATOM   1331 C CE1 . HIS A 1 172 ? -10.82321 -21.99969 8.76260   1.000 17.35161 ? 172 HIS A CE1 1 
ATOM   1332 N NE2 . HIS A 1 172 ? -11.02785 -22.40537 7.52075   1.000 21.50826 ? 172 HIS A NE2 1 
ATOM   1333 N N   . ALA A 1 173 ? -17.23719 -23.81583 8.02983   1.000 12.52263 ? 173 ALA A N   1 
ATOM   1334 C CA  . ALA A 1 173 ? -18.59563 -24.27193 8.25931   1.000 12.65877 ? 173 ALA A CA  1 
ATOM   1335 C C   . ALA A 1 173 ? -18.63885 -25.78943 8.18639   1.000 11.42367 ? 173 ALA A C   1 
ATOM   1336 O O   . ALA A 1 173 ? -17.86461 -26.42248 7.45893   1.000 14.25417 ? 173 ALA A O   1 
ATOM   1337 C CB  . ALA A 1 173 ? -19.57040 -23.67475 7.23693   1.000 15.93369 ? 173 ALA A CB  1 
ATOM   1338 N N   . GLY A 1 174 ? -19.55265 -26.36755 8.94885   1.000 12.55381 ? 174 GLY A N   1 
ATOM   1339 C CA  . GLY A 1 174 ? -19.66795 -27.80978 8.95434   1.000 13.73145 ? 174 GLY A CA  1 
ATOM   1340 C C   . GLY A 1 174 ? -20.95468 -28.22642 9.62059   1.000 13.65163 ? 174 GLY A C   1 
ATOM   1341 O O   . GLY A 1 174 ? -21.83884 -27.40862 9.86120   1.000 12.45846 ? 174 GLY A O   1 
ATOM   1342 N N   . THR A 1 175 ? -21.02480 -29.51211 9.95002   1.000 13.84633 ? 175 THR A N   1 
ATOM   1343 C CA  . THR A 1 175 ? -22.25698 -30.15219 10.39772  1.000 11.88881 ? 175 THR A CA  1 
ATOM   1344 C C   . THR A 1 175 ? -22.07359 -30.78352 11.77339  1.000 14.26021 ? 175 THR A C   1 
ATOM   1345 O O   . THR A 1 175 ? -20.96038 -30.93978 12.27683  1.000 14.98896 ? 175 THR A O   1 
ATOM   1346 C CB  . THR A 1 175 ? -22.70914 -31.24540 9.40479   1.000 11.20611 ? 175 THR A CB  1 
ATOM   1347 O OG1 . THR A 1 175 ? -21.79263 -32.33941 9.45179   1.000 13.44269 ? 175 THR A OG1 1 
ATOM   1348 C CG2 . THR A 1 175 ? -22.76892 -30.73007 7.99364   1.000 11.99727 ? 175 THR A CG2 1 
ATOM   1349 N N   . ASP A 1 176 ? -23.20028 -31.16268 12.36483  1.000 11.73230 ? 176 ASP A N   1 
ATOM   1350 C CA  . ASP A 1 176 ? -23.15862 -32.13036 13.45765  1.000 14.83047 ? 176 ASP A CA  1 
ATOM   1351 C C   . ASP A 1 176 ? -22.94404 -33.52913 12.85181  1.000 17.97138 ? 176 ASP A C   1 
ATOM   1352 O O   . ASP A 1 176 ? -22.79330 -33.68448 11.63473  1.000 14.47209 ? 176 ASP A O   1 
ATOM   1353 C CB  . ASP A 1 176 ? -24.42028 -32.00557 14.32490  1.000 18.36065 ? 176 ASP A CB  1 
ATOM   1354 C CG  . ASP A 1 176 ? -25.71211 -32.33768 13.58773  1.000 21.42957 ? 176 ASP A CG  1 
ATOM   1355 O OD1 . ASP A 1 176 ? -25.68624 -33.03746 12.56498  1.000 17.23341 ? 176 ASP A OD1 1 
ATOM   1356 O OD2 . ASP A 1 176 ? -26.78663 -31.89617 14.06917  1.000 24.47306 ? 176 ASP A OD2 1 
ATOM   1357 N N   . LEU A 1 177 ? -22.91882 -34.55926 13.69186  1.000 16.33195 ? 177 LEU A N   1 
ATOM   1358 C CA  . LEU A 1 177 ? -22.58099 -35.88878 13.19074  1.000 15.18566 ? 177 LEU A CA  1 
ATOM   1359 C C   . LEU A 1 177 ? -23.77864 -36.60770 12.58094  1.000 18.60377 ? 177 LEU A C   1 
ATOM   1360 O O   . LEU A 1 177 ? -23.62751 -37.74560 12.11117  1.000 18.41577 ? 177 LEU A O   1 
ATOM   1361 C CB  . LEU A 1 177 ? -21.93137 -36.73941 14.29173  1.000 15.29893 ? 177 LEU A CB  1 
ATOM   1362 C CG  . LEU A 1 177 ? -20.38994 -36.69332 14.28935  1.000 16.51498 ? 177 LEU A CG  1 
ATOM   1363 C CD1 . LEU A 1 177 ? -19.76450 -37.36557 13.07368  1.000 15.23484 ? 177 LEU A CD1 1 
ATOM   1364 C CD2 . LEU A 1 177 ? -19.84787 -35.25264 14.44680  1.000 15.06241 ? 177 LEU A CD2 1 
ATOM   1365 N N   . GLU A 1 178 ? -24.95032 -35.97560 12.59754  1.000 16.48879 ? 178 GLU A N   1 
ATOM   1366 C CA  . GLU A 1 178 ? -26.08817 -36.38989 11.79182  1.000 15.68396 ? 178 GLU A CA  1 
ATOM   1367 C C   . GLU A 1 178 ? -26.12565 -35.67959 10.44288  1.000 18.71299 ? 178 GLU A C   1 
ATOM   1368 O O   . GLU A 1 178 ? -27.05259 -35.89953 9.65140   1.000 18.71563 ? 178 GLU A O   1 
ATOM   1369 C CB  . GLU A 1 178 ? -27.38401 -36.13746 12.56494  1.000 16.22603 ? 178 GLU A CB  1 
ATOM   1370 C CG  . GLU A 1 178 ? -27.51502 -36.98035 13.81624  1.000 22.23916 ? 178 GLU A CG  1 
ATOM   1371 C CD  . GLU A 1 178 ? -28.91481 -36.93370 14.40484  1.000 29.68905 ? 178 GLU A CD  1 
ATOM   1372 O OE1 . GLU A 1 178 ? -29.59619 -35.89892 14.24899  1.000 42.38833 ? 178 GLU A OE1 1 
ATOM   1373 O OE2 . GLU A 1 178 ? -29.33426 -37.93456 15.01612  1.000 43.15829 ? 178 GLU A OE2 1 
ATOM   1374 N N   . GLY A 1 179 ? -25.13254 -34.84466 10.14327  1.000 14.27471 ? 179 GLY A N   1 
ATOM   1375 C CA  . GLY A 1 179 ? -25.05224 -34.24363 8.83109   1.000 13.74056 ? 179 GLY A CA  1 
ATOM   1376 C C   . GLY A 1 179 ? -25.81765 -32.95429 8.64089   1.000 16.21193 ? 179 GLY A C   1 
ATOM   1377 O O   . GLY A 1 179 ? -25.90035 -32.47845 7.50549   1.000 14.99350 ? 179 GLY A O   1 
ATOM   1378 N N   . ASN A 1 180 ? -26.35834 -32.36473 9.71013   1.000 15.03539 ? 180 ASN A N   1 
ATOM   1379 C CA  . ASN A 1 180 ? -27.07954 -31.09920 9.61980   1.000 17.66801 ? 180 ASN A CA  1 
ATOM   1380 C C   . ASN A 1 180 ? -26.09931 -29.95354 9.82040   1.000 14.72779 ? 180 ASN A C   1 
ATOM   1381 O O   . ASN A 1 180 ? -25.48560 -29.84498 10.88322  1.000 15.10650 ? 180 ASN A O   1 
ATOM   1382 C CB  . ASN A 1 180 ? -28.18329 -31.01323 10.67738  1.000 19.45451 ? 180 ASN A CB  1 
ATOM   1383 C CG  . ASN A 1 180 ? -29.20533 -32.12512 10.55597  1.000 23.25387 ? 180 ASN A CG  1 
ATOM   1384 O OD1 . ASN A 1 180 ? -29.28699 -33.01319 11.41181  1.000 35.20771 ? 180 ASN A OD1 1 
ATOM   1385 N ND2 . ASN A 1 180 ? -29.99202 -32.07891 9.49957   1.000 20.86320 ? 180 ASN A ND2 1 
ATOM   1386 N N   . PHE A 1 181 ? -25.98883 -29.07459 8.82443   1.000 16.10214 ? 181 PHE A N   1 
ATOM   1387 C CA  . PHE A 1 181 ? -25.11092 -27.91802 8.97472   1.000 11.23240 ? 181 PHE A CA  1 
ATOM   1388 C C   . PHE A 1 181 ? -25.49668 -27.09939 10.19719  1.000 17.73244 ? 181 PHE A C   1 
ATOM   1389 O O   . PHE A 1 181 ? -26.67503 -26.97386 10.55448  1.000 17.52701 ? 181 PHE A O   1 
ATOM   1390 C CB  . PHE A 1 181 ? -25.14903 -27.03159 7.72345   1.000 16.02366 ? 181 PHE A CB  1 
ATOM   1391 C CG  . PHE A 1 181 ? -24.06073 -27.34159 6.73882   1.000 15.28770 ? 181 PHE A CG  1 
ATOM   1392 C CD1 . PHE A 1 181 ? -22.82787 -26.72678 6.83440   1.000 14.86871 ? 181 PHE A CD1 1 
ATOM   1393 C CD2 . PHE A 1 181 ? -24.27333 -28.25814 5.71429   1.000 14.14153 ? 181 PHE A CD2 1 
ATOM   1394 C CE1 . PHE A 1 181 ? -21.82045 -27.01392 5.95264   1.000 15.04328 ? 181 PHE A CE1 1 
ATOM   1395 C CE2 . PHE A 1 181 ? -23.28083 -28.54603 4.82180   1.000 15.32952 ? 181 PHE A CE2 1 
ATOM   1396 C CZ  . PHE A 1 181 ? -22.03587 -27.94010 4.94097   1.000 16.09822 ? 181 PHE A CZ  1 
ATOM   1397 N N   . TYR A 1 182 ? -24.48498 -26.55606 10.84179  1.000 15.21813 ? 182 TYR A N   1 
ATOM   1398 C CA  . TYR A 1 182 ? -24.68072 -25.42224 11.71732  1.000 15.57153 ? 182 TYR A CA  1 
ATOM   1399 C C   . TYR A 1 182 ? -24.82933 -24.18578 10.85505  1.000 14.48815 ? 182 TYR A C   1 
ATOM   1400 O O   . TYR A 1 182 ? -24.02422 -23.95308 9.94745   1.000 17.70736 ? 182 TYR A O   1 
ATOM   1401 C CB  . TYR A 1 182 ? -23.49408 -25.27867 12.66098  1.000 17.06916 ? 182 TYR A CB  1 
ATOM   1402 C CG  . TYR A 1 182 ? -23.38462 -26.38524 13.69472  1.000 15.57117 ? 182 TYR A CG  1 
ATOM   1403 C CD1 . TYR A 1 182 ? -24.13270 -26.32271 14.87410  1.000 20.38530 ? 182 TYR A CD1 1 
ATOM   1404 C CD2 . TYR A 1 182 ? -22.52056 -27.46829 13.50372  1.000 14.31623 ? 182 TYR A CD2 1 
ATOM   1405 C CE1 . TYR A 1 182 ? -24.03904 -27.30610 15.84291  1.000 15.31237 ? 182 TYR A CE1 1 
ATOM   1406 C CE2 . TYR A 1 182 ? -22.42492 -28.46133 14.43386  1.000 12.02314 ? 182 TYR A CE2 1 
ATOM   1407 C CZ  . TYR A 1 182 ? -23.17827 -28.38461 15.62058  1.000 16.82357 ? 182 TYR A CZ  1 
ATOM   1408 O OH  . TYR A 1 182 ? -23.09356 -29.36877 16.59925  1.000 16.45606 ? 182 TYR A OH  1 
ATOM   1409 N N   . GLY A 1 183 ? -25.85789 -23.40039 11.12078  1.000 14.67841 ? 183 GLY A N   1 
ATOM   1410 C CA  . GLY A 1 183 ? -26.06887 -22.19060 10.36401  1.000 15.05078 ? 183 GLY A CA  1 
ATOM   1411 C C   . GLY A 1 183 ? -26.76108 -22.44178 9.04492   1.000 16.63670 ? 183 GLY A C   1 
ATOM   1412 O O   . GLY A 1 183 ? -27.21069 -23.55422 8.74068   1.000 16.34069 ? 183 GLY A O   1 
ATOM   1413 N N   . PRO A 1 184 ? -26.82651 -21.39446 8.22255   1.000 15.85958 ? 184 PRO A N   1 
ATOM   1414 C CA  . PRO A 1 184 ? -27.54405 -21.47033 6.94533   1.000 15.65535 ? 184 PRO A CA  1 
ATOM   1415 C C   . PRO A 1 184 ? -26.77535 -22.14337 5.82364   1.000 16.54295 ? 184 PRO A C   1 
ATOM   1416 O O   . PRO A 1 184 ? -27.26422 -22.15842 4.69046   1.000 20.34126 ? 184 PRO A O   1 
ATOM   1417 C CB  . PRO A 1 184 ? -27.77677 -19.98467 6.61278   1.000 22.30069 ? 184 PRO A CB  1 
ATOM   1418 C CG  . PRO A 1 184 ? -26.55973 -19.31503 7.20862   1.000 19.35385 ? 184 PRO A CG  1 
ATOM   1419 C CD  . PRO A 1 184 ? -26.32126 -20.03615 8.50134   1.000 20.08857 ? 184 PRO A CD  1 
ATOM   1420 N N   . PHE A 1 185 ? -25.59815 -22.69693 6.08260   1.000 16.25433 ? 185 PHE A N   1 
ATOM   1421 C CA  . PHE A 1 185 ? -24.70078 -23.05017 4.99655   1.000 17.60780 ? 185 PHE A CA  1 
ATOM   1422 C C   . PHE A 1 185 ? -25.09478 -24.35999 4.32274   1.000 17.59293 ? 185 PHE A C   1 
ATOM   1423 O O   . PHE A 1 185 ? -25.79314 -25.20610 4.89243   1.000 16.36125 ? 185 PHE A O   1 
ATOM   1424 C CB  . PHE A 1 185 ? -23.28165 -23.09825 5.53813   1.000 14.72947 ? 185 PHE A CB  1 
ATOM   1425 C CG  . PHE A 1 185 ? -22.95370 -21.86726 6.31205   1.000 20.28088 ? 185 PHE A CG  1 
ATOM   1426 C CD1 . PHE A 1 185 ? -22.86001 -20.66206 5.64772   1.000 16.49179 ? 185 PHE A CD1 1 
ATOM   1427 C CD2 . PHE A 1 185 ? -22.83875 -21.88449 7.68884   1.000 17.70710 ? 185 PHE A CD2 1 
ATOM   1428 C CE1 . PHE A 1 185 ? -22.61164 -19.49001 6.34780   1.000 17.77438 ? 185 PHE A CE1 1 
ATOM   1429 C CE2 . PHE A 1 185 ? -22.58380 -20.72297 8.39172   1.000 19.05619 ? 185 PHE A CE2 1 
ATOM   1430 C CZ  . PHE A 1 185 ? -22.46128 -19.52240 7.72387   1.000 15.50058 ? 185 PHE A CZ  1 
ATOM   1431 N N   . VAL A 1 186 ? -24.66387 -24.48264 3.06121   1.000 20.33414 ? 186 VAL A N   1 
ATOM   1432 C CA  . VAL A 1 186 ? -24.86942 -25.66978 2.24532   1.000 17.62001 ? 186 VAL A CA  1 
ATOM   1433 C C   . VAL A 1 186 ? -23.51601 -26.13364 1.71842   1.000 18.68418 ? 186 VAL A C   1 
ATOM   1434 O O   . VAL A 1 186 ? -22.55152 -25.36699 1.65315   1.000 18.50147 ? 186 VAL A O   1 
ATOM   1435 C CB  . VAL A 1 186 ? -25.84842 -25.39655 1.08884   1.000 20.76742 ? 186 VAL A CB  1 
ATOM   1436 C CG1 . VAL A 1 186 ? -27.18959 -24.92359 1.64079   1.000 23.13064 ? 186 VAL A CG1 1 
ATOM   1437 C CG2 . VAL A 1 186 ? -25.26346 -24.35975 0.14746   1.000 17.96706 ? 186 VAL A CG2 1 
ATOM   1438 N N   . ASP A 1 187 ? -23.44435 -27.41666 1.33947   1.000 17.36935 ? 187 ASP A N   1 
ATOM   1439 C CA  . ASP A 1 187 ? -22.18947 -27.96231 0.82188   1.000 16.80573 ? 187 ASP A CA  1 
ATOM   1440 C C   . ASP A 1 187 ? -22.13378 -27.78489 -0.69990  1.000 16.17454 ? 187 ASP A C   1 
ATOM   1441 O O   . ASP A 1 187 ? -22.23002 -28.71384 -1.49408  1.000 20.33200 ? 187 ASP A O   1 
ATOM   1442 C CB  . ASP A 1 187 ? -21.98334 -29.41143 1.27229   1.000 17.39215 ? 187 ASP A CB  1 
ATOM   1443 C CG  . ASP A 1 187 ? -23.21396 -30.30752 1.11739   1.000 19.17274 ? 187 ASP A CG  1 
ATOM   1444 O OD1 . ASP A 1 187 ? -24.31522 -29.85717 0.76128   1.000 18.01671 ? 187 ASP A OD1 1 
ATOM   1445 O OD2 . ASP A 1 187 ? -23.06250 -31.51715 1.40103   1.000 18.22931 ? 187 ASP A OD2 1 
ATOM   1446 N N   . ARG A 1 188 ? -21.93513 -26.52449 -1.08260  1.000 18.39790 ? 188 ARG A N   1 
ATOM   1447 C CA  . ARG A 1 188 ? -21.86224 -26.11761 -2.47447  1.000 18.40703 ? 188 ARG A CA  1 
ATOM   1448 C C   . ARG A 1 188 ? -20.86511 -24.97107 -2.55838  1.000 21.91414 ? 188 ARG A C   1 
ATOM   1449 O O   . ARG A 1 188 ? -20.81487 -24.12789 -1.66139  1.000 20.03755 ? 188 ARG A O   1 
ATOM   1450 C CB  . ARG A 1 188 ? -23.25490 -25.70150 -2.97369  1.000 18.66628 ? 188 ARG A CB  1 
ATOM   1451 C CG  . ARG A 1 188 ? -23.29982 -25.10126 -4.33881  1.000 28.40677 ? 188 ARG A CG  1 
ATOM   1452 C CD  . ARG A 1 188 ? -24.74206 -24.91548 -4.76097  1.000 29.43539 ? 188 ARG A CD  1 
ATOM   1453 N NE  . ARG A 1 188 ? -24.83897 -24.28064 -6.06524  1.000 40.54677 ? 188 ARG A NE  1 
ATOM   1454 C CZ  . ARG A 1 188 ? -25.93202 -23.68094 -6.50776  1.000 36.29491 ? 188 ARG A CZ  1 
ATOM   1455 N NH1 . ARG A 1 188 ? -27.04059 -23.65212 -5.78236  1.000 39.62674 ? 188 ARG A NH1 1 
ATOM   1456 N NH2 . ARG A 1 188 ? -25.90732 -23.08517 -7.69756  1.000 34.52119 ? 188 ARG A NH2 1 
ATOM   1457 N N   . GLN A 1 189 ? -20.05313 -24.95978 -3.61444  1.000 21.80492 ? 189 GLN A N   1 
ATOM   1458 C CA  . GLN A 1 189 ? -19.02627 -23.92741 -3.76716  1.000 23.42054 ? 189 GLN A CA  1 
ATOM   1459 C C   . GLN A 1 189 ? -19.66531 -22.69133 -4.39498  1.000 27.08931 ? 189 GLN A C   1 
ATOM   1460 O O   . GLN A 1 189 ? -19.50896 -22.38596 -5.58229  1.000 28.77015 ? 189 GLN A O   1 
ATOM   1461 C CB  . GLN A 1 189 ? -17.85046 -24.43387 -4.59031  1.000 27.69733 ? 189 GLN A CB  1 
ATOM   1462 C CG  . GLN A 1 189 ? -16.65424 -23.48096 -4.53296  1.000 41.50190 ? 189 GLN A CG  1 
ATOM   1463 C CD  . GLN A 1 189 ? -15.68915 -23.67282 -5.68012  1.000 45.99011 ? 189 GLN A CD  1 
ATOM   1464 O OE1 . GLN A 1 189 ? -15.18184 -24.77221 -5.90515  1.000 64.23349 ? 189 GLN A OE1 1 
ATOM   1465 N NE2 . GLN A 1 189 ? -15.43325 -22.60005 -6.42128  1.000 38.34442 ? 189 GLN A NE2 1 
ATOM   1466 N N   . ILE A 1 190 ? -20.42031 -21.97283 -3.56876  1.000 24.06595 ? 190 ILE A N   1 
ATOM   1467 C CA  . ILE A 1 190 ? -20.96710 -20.67261 -3.92704  1.000 22.12808 ? 190 ILE A CA  1 
ATOM   1468 C C   . ILE A 1 190 ? -20.66146 -19.70956 -2.79168  1.000 25.45857 ? 190 ILE A C   1 
ATOM   1469 O O   . ILE A 1 190 ? -20.30026 -20.10941 -1.68092  1.000 21.98474 ? 190 ILE A O   1 
ATOM   1470 C CB  . ILE A 1 190 ? -22.48645 -20.71525 -4.20392  1.000 25.09712 ? 190 ILE A CB  1 
ATOM   1471 C CG1 . ILE A 1 190 ? -23.23435 -21.30500 -3.01005  1.000 26.13160 ? 190 ILE A CG1 1 
ATOM   1472 C CG2 . ILE A 1 190 ? -22.78703 -21.50795 -5.48489  1.000 24.80755 ? 190 ILE A CG2 1 
ATOM   1473 C CD1 . ILE A 1 190 ? -24.71417 -21.40835 -3.23126  1.000 29.90480 ? 190 ILE A CD1 1 
ATOM   1474 N N   . ALA A 1 191 ? -20.80268 -18.41931 -3.07981  1.000 24.65471 ? 191 ALA A N   1 
ATOM   1475 C CA  . ALA A 1 191 ? -20.68917 -17.43933 -2.00964  1.000 23.42694 ? 191 ALA A CA  1 
ATOM   1476 C C   . ALA A 1 191 ? -21.88031 -17.58231 -1.07488  1.000 22.09174 ? 191 ALA A C   1 
ATOM   1477 O O   . ALA A 1 191 ? -23.01100 -17.78694 -1.51487  1.000 24.08442 ? 191 ALA A O   1 
ATOM   1478 C CB  . ALA A 1 191 ? -20.60539 -16.02420 -2.57478  1.000 29.96069 ? 191 ALA A CB  1 
ATOM   1479 N N   . GLN A 1 192 ? -21.60862 -17.52564 0.23162   1.000 21.48596 ? 192 GLN A N   1 
ATOM   1480 C CA  . GLN A 1 192 ? -22.61771 -17.77743 1.25733   1.000 21.93032 ? 192 GLN A CA  1 
ATOM   1481 C C   . GLN A 1 192 ? -22.47701 -16.73823 2.35548   1.000 19.68815 ? 192 GLN A C   1 
ATOM   1482 O O   . GLN A 1 192 ? -21.40954 -16.62873 2.96593   1.000 24.91347 ? 192 GLN A O   1 
ATOM   1483 C CB  . GLN A 1 192 ? -22.46974 -19.17784 1.85853   1.000 20.16919 ? 192 GLN A CB  1 
ATOM   1484 C CG  . GLN A 1 192 ? -22.52205 -20.28760 0.83005   1.000 25.29080 ? 192 GLN A CG  1 
ATOM   1485 C CD  . GLN A 1 192 ? -22.63557 -21.64973 1.47031   1.000 20.35701 ? 192 GLN A CD  1 
ATOM   1486 O OE1 . GLN A 1 192 ? -23.53396 -21.88677 2.27928   1.000 20.95160 ? 192 GLN A OE1 1 
ATOM   1487 N NE2 . GLN A 1 192 ? -21.74024 -22.56268 1.10141   1.000 24.06806 ? 192 GLN A NE2 1 
ATOM   1488 N N   . ALA A 1 193 ? -23.55067 -15.99851 2.62504   1.000 19.23411 ? 193 ALA A N   1 
ATOM   1489 C CA  . ALA A 1 193 ? -23.50946 -15.01025 3.69474   1.000 21.74860 ? 193 ALA A CA  1 
ATOM   1490 C C   . ALA A 1 193 ? -23.54672 -15.70386 5.04999   1.000 15.98632 ? 193 ALA A C   1 
ATOM   1491 O O   . ALA A 1 193 ? -24.42103 -16.53484 5.31248   1.000 22.35859 ? 193 ALA A O   1 
ATOM   1492 C CB  . ALA A 1 193 ? -24.68096 -14.03313 3.57257   1.000 19.96846 ? 193 ALA A CB  1 
ATOM   1493 N N   . ALA A 1 194 ? -22.59341 -15.35017 5.92163   1.000 21.85872 ? 194 ALA A N   1 
ATOM   1494 C CA  . ALA A 1 194 ? -22.59864 -15.83396 7.29996   1.000 23.05121 ? 194 ALA A CA  1 
ATOM   1495 C C   . ALA A 1 194 ? -23.46353 -14.98225 8.21741   1.000 18.97764 ? 194 ALA A C   1 
ATOM   1496 O O   . ALA A 1 194 ? -24.00229 -15.49186 9.20819   1.000 31.17802 ? 194 ALA A O   1 
ATOM   1497 C CB  . ALA A 1 194 ? -21.17350 -15.88053 7.85693   1.000 23.96897 ? 194 ALA A CB  1 
ATOM   1498 N N   . GLY A 1 195 ? -23.62820 -13.70912 7.91065   1.000 20.17540 ? 195 GLY A N   1 
ATOM   1499 C CA  . GLY A 1 195 ? -24.43017 -12.86180 8.75762   1.000 28.06512 ? 195 GLY A CA  1 
ATOM   1500 C C   . GLY A 1 195 ? -23.64520 -12.34938 9.95087   1.000 33.28806 ? 195 GLY A C   1 
ATOM   1501 O O   . GLY A 1 195 ? -22.59365 -12.87348 10.32702  1.000 22.13040 ? 195 GLY A O   1 
ATOM   1502 N N   . THR A 1 196 ? -24.18721 -11.29349 10.54648  1.000 23.57766 ? 196 THR A N   1 
ATOM   1503 C CA  . THR A 1 196 ? -23.51662 -10.58482 11.62445  1.000 17.67939 ? 196 THR A CA  1 
ATOM   1504 C C   . THR A 1 196 ? -23.14446 -11.52629 12.76240  1.000 20.34156 ? 196 THR A C   1 
ATOM   1505 O O   . THR A 1 196 ? -23.97548 -12.28418 13.26919  1.000 27.63049 ? 196 THR A O   1 
ATOM   1506 C CB  . THR A 1 196 ? -24.42196 -9.47077  12.13400  1.000 24.00661 ? 196 THR A CB  1 
ATOM   1507 O OG1 . THR A 1 196 ? -24.91312 -8.72537  11.01263  1.000 27.51653 ? 196 THR A OG1 1 
ATOM   1508 C CG2 . THR A 1 196 ? -23.63524 -8.52464  13.04602  1.000 24.85683 ? 196 THR A CG2 1 
ATOM   1509 N N   . ASP A 1 197 ? -21.89123 -11.46532 13.16789  1.000 20.10241 ? 197 ASP A N   1 
ATOM   1510 C CA  . ASP A 1 197 ? -21.46533 -12.19317 14.34316  1.000 19.46087 ? 197 ASP A CA  1 
ATOM   1511 C C   . ASP A 1 197 ? -21.48745 -11.24050 15.52912  1.000 25.99463 ? 197 ASP A C   1 
ATOM   1512 O O   . ASP A 1 197 ? -21.53381 -10.01569 15.37389  1.000 25.49382 ? 197 ASP A O   1 
ATOM   1513 C CB  . ASP A 1 197 ? -20.07201 -12.77606 14.14666  1.000 18.64629 ? 197 ASP A CB  1 
ATOM   1514 C CG  . ASP A 1 197 ? -19.78221 -13.91082 15.09739  1.000 16.51690 ? 197 ASP A CG  1 
ATOM   1515 O OD1 . ASP A 1 197 ? -20.73879 -14.54196 15.60309  1.000 17.13315 ? 197 ASP A OD1 1 
ATOM   1516 O OD2 . ASP A 1 197 ? -18.58573 -14.16568 15.32371  1.000 18.70848 ? 197 ASP A OD2 1 
ATOM   1517 N N   . THR A 1 198 ? -21.48637 -11.81750 16.72147  1.000 19.81574 ? 198 THR A N   1 
ATOM   1518 C CA  . THR A 1 198 ? -21.39270 -11.01692 17.92930  1.000 17.76906 ? 198 THR A CA  1 
ATOM   1519 C C   . THR A 1 198 ? -20.40166 -11.68723 18.86726  1.000 18.18890 ? 198 THR A C   1 
ATOM   1520 O O   . THR A 1 198 ? -20.01624 -12.84939 18.68334  1.000 18.04903 ? 198 THR A O   1 
ATOM   1521 C CB  . THR A 1 198 ? -22.75051 -10.84210 18.61238  1.000 24.86711 ? 198 THR A CB  1 
ATOM   1522 O OG1 . THR A 1 198 ? -23.32931 -12.13097 18.84716  1.000 30.46487 ? 198 THR A OG1 1 
ATOM   1523 C CG2 . THR A 1 198 ? -23.68871 -10.01624 17.73055  1.000 28.42988 ? 198 THR A CG2 1 
ATOM   1524 N N   . THR A 1 199 ? -19.97412 -10.92759 19.86797  1.000 17.06222 ? 199 THR A N   1 
ATOM   1525 C CA  . THR A 1 199 ? -19.07206 -11.45317 20.88733  1.000 18.93917 ? 199 THR A CA  1 
ATOM   1526 C C   . THR A 1 199 ? -19.86296 -12.17574 21.97022  1.000 19.16813 ? 199 THR A C   1 
ATOM   1527 O O   . THR A 1 199 ? -20.93804 -11.73020 22.37287  1.000 17.29881 ? 199 THR A O   1 
ATOM   1528 C CB  . THR A 1 199 ? -18.24329 -10.31866 21.48302  1.000 14.56308 ? 199 THR A CB  1 
ATOM   1529 O OG1 . THR A 1 199 ? -17.45288 -9.73316  20.44983  1.000 20.90165 ? 199 THR A OG1 1 
ATOM   1530 C CG2 . THR A 1 199 ? -17.30361 -10.83913 22.57143  1.000 14.93952 ? 199 THR A CG2 1 
ATOM   1531 N N   . ILE A 1 200 ? -19.33165 -13.31148 22.43442  1.000 16.52700 ? 200 ILE A N   1 
ATOM   1532 C CA  . ILE A 1 200 ? -20.03583 -14.14484 23.40294  1.000 16.41106 ? 200 ILE A CA  1 
ATOM   1533 C C   . ILE A 1 200 ? -19.83227 -13.59380 24.80885  1.000 14.77924 ? 200 ILE A C   1 
ATOM   1534 O O   . ILE A 1 200 ? -18.88042 -13.96274 25.51094  1.000 17.11413 ? 200 ILE A O   1 
ATOM   1535 C CB  . ILE A 1 200 ? -19.57425 -15.61113 23.31705  1.000 12.99537 ? 200 ILE A CB  1 
ATOM   1536 C CG1 . ILE A 1 200 ? -19.61253 -16.09770 21.85474  1.000 16.50123 ? 200 ILE A CG1 1 
ATOM   1537 C CG2 . ILE A 1 200 ? -20.44465 -16.51258 24.18463  1.000 15.57073 ? 200 ILE A CG2 1 
ATOM   1538 C CD1 . ILE A 1 200 ? -18.57646 -17.19423 21.58250  1.000 15.96779 ? 200 ILE A CD1 1 
ATOM   1539 N N   . THR A 1 201 ? -20.77176 -12.74823 25.23941  1.000 15.78576 ? 201 THR A N   1 
ATOM   1540 C CA  . THR A 1 201 ? -20.61801 -11.97741 26.47487  1.000 16.48744 ? 201 THR A CA  1 
ATOM   1541 C C   . THR A 1 201 ? -20.36565 -12.86363 27.69022  1.000 16.21668 ? 201 THR A C   1 
ATOM   1542 O O   . THR A 1 201 ? -19.48761 -12.55563 28.51274  1.000 16.30072 ? 201 THR A O   1 
ATOM   1543 C CB  . THR A 1 201 ? -21.86886 -11.13558 26.68965  1.000 15.70357 ? 201 THR A CB  1 
ATOM   1544 O OG1 . THR A 1 201 ? -22.14719 -10.43733 25.47213  1.000 17.63440 ? 201 THR A OG1 1 
ATOM   1545 C CG2 . THR A 1 201 ? -21.68754 -10.14807 27.87759  1.000 18.17760 ? 201 THR A CG2 1 
ATOM   1546 N N   . VAL A 1 202 ? -21.13243 -13.95498 27.83933  1.000 14.54223 ? 202 VAL A N   1 
ATOM   1547 C CA  . VAL A 1 202 ? -20.98902 -14.77819 29.04567  1.000 12.40943 ? 202 VAL A CA  1 
ATOM   1548 C C   . VAL A 1 202 ? -19.59799 -15.39580 29.09414  1.000 16.99812 ? 202 VAL A C   1 
ATOM   1549 O O   . VAL A 1 202 ? -19.03830 -15.59746 30.17903  1.000 15.54036 ? 202 VAL A O   1 
ATOM   1550 C CB  . VAL A 1 202 ? -22.09489 -15.85048 29.12655  1.000 16.05637 ? 202 VAL A CB  1 
ATOM   1551 C CG1 . VAL A 1 202 ? -21.99224 -16.82811 27.95376  1.000 18.51843 ? 202 VAL A CG1 1 
ATOM   1552 C CG2 . VAL A 1 202 ? -22.05401 -16.57503 30.46739  1.000 16.11724 ? 202 VAL A CG2 1 
ATOM   1553 N N   . ASN A 1 203 ? -19.00461 -15.64977 27.92615  1.000 17.02033 ? 203 ASN A N   1 
ATOM   1554 C CA  . ASN A 1 203 ? -17.64660 -16.19063 27.85518  1.000 12.96004 ? 203 ASN A CA  1 
ATOM   1555 C C   . ASN A 1 203 ? -16.60845 -15.14454 28.22854  1.000 14.76658 ? 203 ASN A C   1 
ATOM   1556 O O   . ASN A 1 203 ? -15.67523 -15.43611 28.99587  1.000 17.96575 ? 203 ASN A O   1 
ATOM   1557 C CB  . ASN A 1 203 ? -17.39631 -16.73878 26.43751  1.000 14.96044 ? 203 ASN A CB  1 
ATOM   1558 C CG  . ASN A 1 203 ? -18.09074 -18.06294 26.18240  1.000 13.25598 ? 203 ASN A CG  1 
ATOM   1559 O OD1 . ASN A 1 203 ? -18.89936 -18.53240 26.98823  1.000 15.72348 ? 203 ASN A OD1 1 
ATOM   1560 N ND2 . ASN A 1 203 ? -17.76429 -18.68528 25.04454  1.000 15.88029 ? 203 ASN A ND2 1 
ATOM   1561 N N   . VAL A 1 204 ? -16.75729 -13.91785 27.72380  1.000 15.68824 ? 204 VAL A N   1 
ATOM   1562 C CA  . VAL A 1 204 ? -15.87839 -12.83202 28.15334  1.000 14.11570 ? 204 VAL A CA  1 
ATOM   1563 C C   . VAL A 1 204 ? -15.90715 -12.70237 29.66981  1.000 15.51173 ? 204 VAL A C   1 
ATOM   1564 O O   . VAL A 1 204 ? -14.86043 -12.55993 30.30969  1.000 16.77663 ? 204 VAL A O   1 
ATOM   1565 C CB  . VAL A 1 204 ? -16.25789 -11.50549 27.47231  1.000 16.71435 ? 204 VAL A CB  1 
ATOM   1566 C CG1 . VAL A 1 204 ? -15.33017 -10.39184 27.96444  1.000 16.94098 ? 204 VAL A CG1 1 
ATOM   1567 C CG2 . VAL A 1 204 ? -16.21786 -11.64341 25.92612  1.000 15.35254 ? 204 VAL A CG2 1 
ATOM   1568 N N   . LEU A 1 205 ? -17.11122 -12.69870 30.25704  1.000 13.98347 ? 205 LEU A N   1 
ATOM   1569 C CA  . LEU A 1 205 ? -17.21347 -12.57652 31.71192  1.000 19.96854 ? 205 LEU A CA  1 
ATOM   1570 C C   . LEU A 1 205 ? -16.51572 -13.73302 32.41065  1.000 16.85197 ? 205 LEU A C   1 
ATOM   1571 O O   . LEU A 1 205 ? -15.81825 -13.52209 33.41332  1.000 16.32077 ? 205 LEU A O   1 
ATOM   1572 C CB  . LEU A 1 205 ? -18.68191 -12.49293 32.14006  1.000 16.19757 ? 205 LEU A CB  1 
ATOM   1573 C CG  . LEU A 1 205 ? -19.37025 -11.18710 31.69814  1.000 19.10511 ? 205 LEU A CG  1 
ATOM   1574 C CD1 . LEU A 1 205 ? -20.87781 -11.33759 31.82708  1.000 18.82568 ? 205 LEU A CD1 1 
ATOM   1575 C CD2 . LEU A 1 205 ? -18.89868 -9.99031  32.53626  1.000 16.48778 ? 205 LEU A CD2 1 
ATOM   1576 N N   . ALA A 1 206 ? -16.68837 -14.96315 31.89899  1.000 15.25959 ? 206 ALA A N   1 
ATOM   1577 C CA  . ALA A 1 206 ? -16.02054 -16.11439 32.51318  1.000 15.35043 ? 206 ALA A CA  1 
ATOM   1578 C C   . ALA A 1 206 ? -14.51320 -15.92303 32.52245  1.000 19.03868 ? 206 ALA A C   1 
ATOM   1579 O O   . ALA A 1 206 ? -13.83066 -16.25240 33.51090  1.000 17.18337 ? 206 ALA A O   1 
ATOM   1580 C CB  . ALA A 1 206 ? -16.36640 -17.39681 31.75655  1.000 14.99362 ? 206 ALA A CB  1 
ATOM   1581 N N   . TRP A 1 207 ? -13.98542 -15.41457 31.41258  1.000 17.06997 ? 207 TRP A N   1 
ATOM   1582 C CA  . TRP A 1 207 ? -12.55670 -15.20170 31.25794  1.000 16.42500 ? 207 TRP A CA  1 
ATOM   1583 C C   . TRP A 1 207 ? -12.06574 -14.08662 32.17457  1.000 22.21410 ? 207 TRP A C   1 
ATOM   1584 O O   . TRP A 1 207 ? -10.96013 -14.16969 32.71922  1.000 19.24981 ? 207 TRP A O   1 
ATOM   1585 C CB  . TRP A 1 207 ? -12.26944 -14.92084 29.78233  1.000 18.71742 ? 207 TRP A CB  1 
ATOM   1586 C CG  . TRP A 1 207 ? -10.90690 -14.44601 29.42490  1.000 18.25621 ? 207 TRP A CG  1 
ATOM   1587 C CD1 . TRP A 1 207 ? -9.78180  -15.20404 29.24991  1.000 17.36764 ? 207 TRP A CD1 1 
ATOM   1588 C CD2 . TRP A 1 207 ? -10.55090 -13.10968 29.09326  1.000 13.83528 ? 207 TRP A CD2 1 
ATOM   1589 N NE1 . TRP A 1 207 ? -8.73168  -14.40154 28.86197  1.000 16.59751 ? 207 TRP A NE1 1 
ATOM   1590 C CE2 . TRP A 1 207 ? -9.17963  -13.11117 28.75772  1.000 17.14624 ? 207 TRP A CE2 1 
ATOM   1591 C CE3 . TRP A 1 207 ? -11.26125 -11.90074 29.04952  1.000 17.54451 ? 207 TRP A CE3 1 
ATOM   1592 C CZ2 . TRP A 1 207 ? -8.51124  -11.96144 28.39146  1.000 19.09306 ? 207 TRP A CZ2 1 
ATOM   1593 C CZ3 . TRP A 1 207 ? -10.58768 -10.75835 28.69296  1.000 14.56568 ? 207 TRP A CZ3 1 
ATOM   1594 C CH2 . TRP A 1 207 ? -9.22927  -10.79777 28.35577  1.000 17.29412 ? 207 TRP A CH2 1 
ATOM   1595 N N   . LEU A 1 208 ? -12.87635 -13.04458 32.37473  1.000 17.24621 ? 208 LEU A N   1 
ATOM   1596 C CA  . LEU A 1 208 ? -12.53344 -12.03996 33.38331  1.000 16.44803 ? 208 LEU A CA  1 
ATOM   1597 C C   . LEU A 1 208 ? -12.43691 -12.65549 34.77437  1.000 21.13810 ? 208 LEU A C   1 
ATOM   1598 O O   . LEU A 1 208 ? -11.55382 -12.28841 35.55772  1.000 17.61489 ? 208 LEU A O   1 
ATOM   1599 C CB  . LEU A 1 208 ? -13.56007 -10.90484 33.36851  1.000 14.51348 ? 208 LEU A CB  1 
ATOM   1600 C CG  . LEU A 1 208 ? -13.46072 -10.00043 32.13254  1.000 18.98415 ? 208 LEU A CG  1 
ATOM   1601 C CD1 . LEU A 1 208 ? -14.49202 -8.90291  32.15630  1.000 17.18762 ? 208 LEU A CD1 1 
ATOM   1602 C CD2 . LEU A 1 208 ? -12.04881 -9.40500  31.91538  1.000 17.20005 ? 208 LEU A CD2 1 
ATOM   1603 N N   . TYR A 1 209 ? -13.33939 -13.58358 35.10674  1.000 14.84809 ? 209 TYR A N   1 
ATOM   1604 C CA  . TYR A 1 209 ? -13.22548 -14.31724 36.36864  1.000 16.17864 ? 209 TYR A CA  1 
ATOM   1605 C C   . TYR A 1 209 ? -11.94918 -15.15073 36.40905  1.000 22.17253 ? 209 TYR A C   1 
ATOM   1606 O O   . TYR A 1 209 ? -11.23832 -15.16513 37.42420  1.000 20.40924 ? 209 TYR A O   1 
ATOM   1607 C CB  . TYR A 1 209 ? -14.45545 -15.20085 36.57104  1.000 18.69785 ? 209 TYR A CB  1 
ATOM   1608 C CG  . TYR A 1 209 ? -15.64902 -14.46146 37.12362  1.000 19.51277 ? 209 TYR A CG  1 
ATOM   1609 C CD1 . TYR A 1 209 ? -15.68413 -14.06294 38.45565  1.000 21.50721 ? 209 TYR A CD1 1 
ATOM   1610 C CD2 . TYR A 1 209 ? -16.74195 -14.17597 36.32572  1.000 17.18310 ? 209 TYR A CD2 1 
ATOM   1611 C CE1 . TYR A 1 209 ? -16.76682 -13.39207 38.96523  1.000 25.06405 ? 209 TYR A CE1 1 
ATOM   1612 C CE2 . TYR A 1 209 ? -17.84089 -13.49868 36.83168  1.000 21.06607 ? 209 TYR A CE2 1 
ATOM   1613 C CZ  . TYR A 1 209 ? -17.84396 -13.10361 38.15028  1.000 24.44522 ? 209 TYR A CZ  1 
ATOM   1614 O OH  . TYR A 1 209 ? -18.93135 -12.42811 38.66058  1.000 22.55579 ? 209 TYR A OH  1 
ATOM   1615 N N   . ALA A 1 210 ? -11.66026 -15.88304 35.32461  1.000 20.72546 ? 210 ALA A N   1 
ATOM   1616 C CA  . ALA A 1 210 ? -10.37589 -16.57435 35.21777  1.000 21.38172 ? 210 ALA A CA  1 
ATOM   1617 C C   . ALA A 1 210 ? -9.21417  -15.62587 35.49384  1.000 17.59921 ? 210 ALA A C   1 
ATOM   1618 O O   . ALA A 1 210 ? -8.24579  -15.99856 36.17290  1.000 24.63056 ? 210 ALA A O   1 
ATOM   1619 C CB  . ALA A 1 210 ? -10.22594 -17.20984 33.83225  1.000 23.69864 ? 210 ALA A CB  1 
ATOM   1620 N N   . ALA A 1 211 ? -9.29648  -14.38553 34.99699  1.000 16.53310 ? 211 ALA A N   1 
ATOM   1621 C CA  . ALA A 1 211 ? -8.20677  -13.43754 35.16800  1.000 18.46190 ? 211 ALA A CA  1 
ATOM   1622 C C   . ALA A 1 211 ? -8.05424  -13.05273 36.63519  1.000 23.50311 ? 211 ALA A C   1 
ATOM   1623 O O   . ALA A 1 211 ? -6.93429  -12.99134 37.15846  1.000 25.43454 ? 211 ALA A O   1 
ATOM   1624 C CB  . ALA A 1 211 ? -8.44144  -12.19682 34.30387  1.000 20.19238 ? 211 ALA A CB  1 
ATOM   1625 N N   . VAL A 1 212 ? -9.17343  -12.80746 37.31391  1.000 19.13145 ? 212 VAL A N   1 
ATOM   1626 C CA  . VAL A 1 212 ? -9.11375  -12.44065 38.72752  1.000 29.01020 ? 212 VAL A CA  1 
ATOM   1627 C C   . VAL A 1 212 ? -8.49936  -13.57101 39.53805  1.000 25.98894 ? 212 VAL A C   1 
ATOM   1628 O O   . VAL A 1 212 ? -7.65312  -13.33711 40.41294  1.000 26.18732 ? 212 VAL A O   1 
ATOM   1629 C CB  . VAL A 1 212 ? -10.51683 -12.06222 39.24472  1.000 25.29213 ? 212 VAL A CB  1 
ATOM   1630 C CG1 . VAL A 1 212 ? -10.53977 -11.97998 40.79332  1.000 21.68465 ? 212 VAL A CG1 1 
ATOM   1631 C CG2 . VAL A 1 212 ? -10.95236 -10.73307 38.64883  1.000 20.30706 ? 212 VAL A CG2 1 
ATOM   1632 N N   . ILE A 1 213 ? -8.91969  -14.80907 39.26402  1.000 24.05704 ? 213 ILE A N   1 
ATOM   1633 C CA  . ILE A 1 213 ? -8.42187  -15.97581 39.99530  1.000 22.35831 ? 213 ILE A CA  1 
ATOM   1634 C C   . ILE A 1 213 ? -6.90595  -16.06937 39.87485  1.000 33.70162 ? 213 ILE A C   1 
ATOM   1635 O O   . ILE A 1 213 ? -6.20443  -16.41236 40.84012  1.000 27.28657 ? 213 ILE A O   1 
ATOM   1636 C CB  . ILE A 1 213 ? -9.12530  -17.24943 39.47705  1.000 24.99266 ? 213 ILE A CB  1 
ATOM   1637 C CG1 . ILE A 1 213 ? -10.59590 -17.28145 39.91791  1.000 23.70285 ? 213 ILE A CG1 1 
ATOM   1638 C CG2 . ILE A 1 213 ? -8.39996  -18.51939 39.91060  1.000 23.78726 ? 213 ILE A CG2 1 
ATOM   1639 C CD1 . ILE A 1 213 ? -11.44431 -18.30427 39.16211  1.000 23.59359 ? 213 ILE A CD1 1 
ATOM   1640 N N   . ASN A 1 214 ? -6.37358  -15.71553 38.70649  1.000 21.87819 ? 214 ASN A N   1 
ATOM   1641 C CA  . ASN A 1 214 ? -4.94361  -15.81914 38.43064  1.000 22.80017 ? 214 ASN A CA  1 
ATOM   1642 C C   . ASN A 1 214 ? -4.16366  -14.54703 38.75625  1.000 23.61795 ? 214 ASN A C   1 
ATOM   1643 O O   . ASN A 1 214 ? -2.95305  -14.50444 38.51486  1.000 38.30128 ? 214 ASN A O   1 
ATOM   1644 C CB  . ASN A 1 214 ? -4.73370  -16.22698 36.96625  1.000 30.08499 ? 214 ASN A CB  1 
ATOM   1645 C CG  . ASN A 1 214 ? -5.04551  -17.70066 36.72893  1.000 31.28095 ? 214 ASN A CG  1 
ATOM   1646 O OD1 . ASN A 1 214 ? -4.15906  -18.55075 36.82801  1.000 46.40126 ? 214 ASN A OD1 1 
ATOM   1647 N ND2 . ASN A 1 214 ? -6.30617  -18.01443 36.44371  1.000 29.01695 ? 214 ASN A ND2 1 
ATOM   1648 N N   . GLY A 1 215 ? -4.81170  -13.51118 39.28714  1.000 29.70486 ? 215 GLY A N   1 
ATOM   1649 C CA  . GLY A 1 215 ? -4.12303  -12.34709 39.81195  1.000 25.28411 ? 215 GLY A CA  1 
ATOM   1650 C C   . GLY A 1 215 ? -4.16795  -11.10995 38.94487  1.000 42.62118 ? 215 GLY A C   1 
ATOM   1651 O O   . GLY A 1 215 ? -3.72608  -10.04482 39.39753  1.000 29.32039 ? 215 GLY A O   1 
ATOM   1652 N N   . ASP A 1 216 ? -4.65667  -11.20874 37.71167  1.000 25.08843 ? 216 ASP A N   1 
ATOM   1653 C CA  . ASP A 1 216 ? -4.89113  -10.03504 36.88437  1.000 25.42330 ? 216 ASP A CA  1 
ATOM   1654 C C   . ASP A 1 216 ? -6.17505  -9.38362  37.37629  1.000 38.80936 ? 216 ASP A C   1 
ATOM   1655 O O   . ASP A 1 216 ? -7.26702  -9.92094  37.16526  1.000 35.08492 ? 216 ASP A O   1 
ATOM   1656 C CB  . ASP A 1 216 ? -5.02095  -10.43692 35.41874  1.000 22.95349 ? 216 ASP A CB  1 
ATOM   1657 C CG  . ASP A 1 216 ? -3.80911  -10.08567 34.59955  1.000 45.29057 ? 216 ASP A CG  1 
ATOM   1658 O OD1 . ASP A 1 216 ? -3.09920  -9.12465  34.96367  1.000 54.37553 ? 216 ASP A OD1 1 
ATOM   1659 O OD2 . ASP A 1 216 ? -3.58211  -10.77240 33.57664  1.000 33.93292 ? 216 ASP A OD2 1 
ATOM   1660 N N   . ARG A 1 217 ? -6.05709  -8.23595  38.04536  1.000 29.41706 ? 217 ARG A N   1 
ATOM   1661 C CA  . ARG A 1 217 ? -7.21294  -7.62280  38.68645  1.000 26.87776 ? 217 ARG A CA  1 
ATOM   1662 C C   . ARG A 1 217 ? -7.32549  -6.12893  38.41212  1.000 22.48616 ? 217 ARG A C   1 
ATOM   1663 O O   . ARG A 1 217 ? -8.23842  -5.48591  38.94589  1.000 30.61152 ? 217 ARG A O   1 
ATOM   1664 C CB  . ARG A 1 217 ? -7.17336  -7.87664  40.20097  1.000 33.69084 ? 217 ARG A CB  1 
ATOM   1665 N N   . TRP A 1 218 ? -6.45461  -5.56317  37.56805  1.000 29.64042 ? 218 TRP A N   1 
ATOM   1666 C CA  . TRP A 1 218 ? -6.44067  -4.11547  37.38029  1.000 28.24647 ? 218 TRP A CA  1 
ATOM   1667 C C   . TRP A 1 218 ? -7.75557  -3.58436  36.82737  1.000 32.69113 ? 218 TRP A C   1 
ATOM   1668 O O   . TRP A 1 218 ? -8.07667  -2.40907  37.03964  1.000 33.52997 ? 218 TRP A O   1 
ATOM   1669 C CB  . TRP A 1 218 ? -5.29709  -3.70240  36.45007  1.000 30.78365 ? 218 TRP A CB  1 
ATOM   1670 C CG  . TRP A 1 218 ? -5.40394  -4.25868  35.03419  1.000 30.11136 ? 218 TRP A CG  1 
ATOM   1671 C CD1 . TRP A 1 218 ? -4.75727  -5.35298  34.53984  1.000 37.52800 ? 218 TRP A CD1 1 
ATOM   1672 C CD2 . TRP A 1 218 ? -6.20036  -3.74186  33.95346  1.000 34.07172 ? 218 TRP A CD2 1 
ATOM   1673 N NE1 . TRP A 1 218 ? -5.09994  -5.54925  33.21973  1.000 30.99012 ? 218 TRP A NE1 1 
ATOM   1674 C CE2 . TRP A 1 218 ? -5.97982  -4.57287  32.83821  1.000 35.01214 ? 218 TRP A CE2 1 
ATOM   1675 C CE3 . TRP A 1 218 ? -7.07212  -2.65375  33.81918  1.000 31.94200 ? 218 TRP A CE3 1 
ATOM   1676 C CZ2 . TRP A 1 218 ? -6.59714  -4.35581  31.61232  1.000 22.18384 ? 218 TRP A CZ2 1 
ATOM   1677 C CZ3 . TRP A 1 218 ? -7.68874  -2.44049  32.59749  1.000 42.21184 ? 218 TRP A CZ3 1 
ATOM   1678 C CH2 . TRP A 1 218 ? -7.44981  -3.29151  31.50913  1.000 33.32080 ? 218 TRP A CH2 1 
ATOM   1679 N N   . PHE A 1 219 ? -8.51430  -4.41365  36.11015  1.000 28.82973 ? 219 PHE A N   1 
ATOM   1680 C CA  . PHE A 1 219 ? -9.74511  -3.96790  35.47101  1.000 35.03553 ? 219 PHE A CA  1 
ATOM   1681 C C   . PHE A 1 219 ? -10.92608 -3.90573  36.43266  1.000 29.84076 ? 219 PHE A C   1 
ATOM   1682 O O   . PHE A 1 219 ? -11.99383 -3.42019  36.04519  1.000 29.59010 ? 219 PHE A O   1 
ATOM   1683 C CB  . PHE A 1 219 ? -10.07579 -4.89586  34.29556  1.000 22.60286 ? 219 PHE A CB  1 
ATOM   1684 C CG  . PHE A 1 219 ? -10.09163 -6.34309  34.67170  1.000 21.67887 ? 219 PHE A CG  1 
ATOM   1685 C CD1 . PHE A 1 219 ? -11.23030 -6.92248  35.19621  1.000 19.24574 ? 219 PHE A CD1 1 
ATOM   1686 C CD2 . PHE A 1 219 ? -8.95807  -7.11687  34.53989  1.000 19.31922 ? 219 PHE A CD2 1 
ATOM   1687 C CE1 . PHE A 1 219 ? -11.25237 -8.24440  35.56883  1.000 22.83023 ? 219 PHE A CE1 1 
ATOM   1688 C CE2 . PHE A 1 219 ? -8.97209  -8.44258  34.92277  1.000 18.93864 ? 219 PHE A CE2 1 
ATOM   1689 C CZ  . PHE A 1 219 ? -10.12865 -9.00938  35.43430  1.000 20.03365 ? 219 PHE A CZ  1 
ATOM   1690 N N   . LEU A 1 220 ? -10.77310 -4.40113  37.65531  1.000 30.43391 ? 220 LEU A N   1 
ATOM   1691 C CA  . LEU A 1 220 ? -11.83504 -4.27990  38.64619  1.000 30.15799 ? 220 LEU A CA  1 
ATOM   1692 C C   . LEU A 1 220 ? -11.98980 -2.82444  39.06454  1.000 30.93876 ? 220 LEU A C   1 
ATOM   1693 O O   . LEU A 1 220 ? -11.00863 -2.16479  39.42266  1.000 38.55330 ? 220 LEU A O   1 
ATOM   1694 C CB  . LEU A 1 220 ? -11.53382 -5.14497  39.86479  1.000 24.20982 ? 220 LEU A CB  1 
ATOM   1695 C CG  . LEU A 1 220 ? -11.43905 -6.65111  39.60880  1.000 24.78032 ? 220 LEU A CG  1 
ATOM   1696 C CD1 . LEU A 1 220 ? -11.05731 -7.39098  40.86865  1.000 25.76901 ? 220 LEU A CD1 1 
ATOM   1697 C CD2 . LEU A 1 220 ? -12.75778 -7.16477  39.06163  1.000 28.08542 ? 220 LEU A CD2 1 
ATOM   1698 N N   . ASN A 1 221 ? -13.21988 -2.32389  39.02585  1.000 34.89628 ? 221 ASN A N   1 
ATOM   1699 C CA  . ASN A 1 221 ? -13.48750 -0.91328  39.27587  1.000 40.32573 ? 221 ASN A CA  1 
ATOM   1700 C C   . ASN A 1 221 ? -14.42334 -0.74504  40.47378  1.000 39.05241 ? 221 ASN A C   1 
ATOM   1701 O O   . ASN A 1 221 ? -14.88263 -1.71618  41.07590  1.000 34.41190 ? 221 ASN A O   1 
ATOM   1702 C CB  . ASN A 1 221 ? -14.06774 -0.24479  38.02768  1.000 40.43776 ? 221 ASN A CB  1 
ATOM   1703 C CG  . ASN A 1 221 ? -15.42410 -0.81036  37.62519  1.000 43.55889 ? 221 ASN A CG  1 
ATOM   1704 O OD1 . ASN A 1 221 ? -16.20543 -1.27475  38.45616  1.000 34.39365 ? 221 ASN A OD1 1 
ATOM   1705 N ND2 . ASN A 1 221 ? -15.71153 -0.75757  36.33232  1.000 51.48079 ? 221 ASN A ND2 1 
ATOM   1706 N N   . ARG A 1 222 ? -14.71846 0.51710   40.79445  1.000 47.68659 ? 222 ARG A N   1 
ATOM   1707 C CA  . ARG A 1 222 ? -15.60628 0.88271   41.89274  1.000 51.46718 ? 222 ARG A CA  1 
ATOM   1708 C C   . ARG A 1 222 ? -17.07177 0.98458   41.47863  1.000 45.89045 ? 222 ARG A C   1 
ATOM   1709 O O   . ARG A 1 222 ? -17.91140 1.33117   42.31601  1.000 49.38042 ? 222 ARG A O   1 
ATOM   1710 C CB  . ARG A 1 222 ? -15.16193 2.21933   42.50504  1.000 40.45566 ? 222 ARG A CB  1 
ATOM   1711 N N   . PHE A 1 223 ? -17.39911 0.69694   40.22382  1.000 33.89432 ? 223 PHE A N   1 
ATOM   1712 C CA  . PHE A 1 223 ? -18.75095 0.84277   39.70478  1.000 31.22879 ? 223 PHE A CA  1 
ATOM   1713 C C   . PHE A 1 223 ? -19.51883 -0.46786  39.78227  1.000 34.16464 ? 223 PHE A C   1 
ATOM   1714 O O   . PHE A 1 223 ? -18.94829 -1.55402  39.91778  1.000 31.25768 ? 223 PHE A O   1 
ATOM   1715 C CB  . PHE A 1 223 ? -18.73442 1.32057   38.25002  1.000 40.93687 ? 223 PHE A CB  1 
ATOM   1716 C CG  . PHE A 1 223 ? -17.78897 2.45451   37.99029  1.000 42.74966 ? 223 PHE A CG  1 
ATOM   1717 C CD1 . PHE A 1 223 ? -16.47437 2.20783   37.63918  1.000 53.10157 ? 223 PHE A CD1 1 
ATOM   1718 C CD2 . PHE A 1 223 ? -18.21503 3.76699   38.08400  1.000 67.32656 ? 223 PHE A CD2 1 
ATOM   1719 C CE1 . PHE A 1 223 ? -15.59330 3.24192   37.39687  1.000 55.42851 ? 223 PHE A CE1 1 
ATOM   1720 C CE2 . PHE A 1 223 ? -17.33898 4.80899   37.83538  1.000 73.49292 ? 223 PHE A CE2 1 
ATOM   1721 C CZ  . PHE A 1 223 ? -16.02519 4.54451   37.49567  1.000 64.91675 ? 223 PHE A CZ  1 
ATOM   1722 N N   . THR A 1 224 ? -20.83529 -0.34930  39.69036  1.000 21.17682 ? 224 THR A N   1 
ATOM   1723 C CA  . THR A 1 224 ? -21.68338 -1.47751  39.35095  1.000 24.88922 ? 224 THR A CA  1 
ATOM   1724 C C   . THR A 1 224 ? -22.65667 -1.03113  38.26992  1.000 25.69541 ? 224 THR A C   1 
ATOM   1725 O O   . THR A 1 224 ? -22.62972 0.11252   37.79954  1.000 25.73193 ? 224 THR A O   1 
ATOM   1726 C CB  . THR A 1 224 ? -22.41622 -2.04797  40.56923  1.000 33.05130 ? 224 THR A CB  1 
ATOM   1727 O OG1 . THR A 1 224 ? -22.92223 -3.35755  40.24697  1.000 26.60481 ? 224 THR A OG1 1 
ATOM   1728 C CG2 . THR A 1 224 ? -23.56482 -1.12698  40.99120  1.000 31.34827 ? 224 THR A CG2 1 
ATOM   1729 N N   . THR A 1 225 ? -23.50808 -1.95130  37.84588  1.000 23.06975 ? 225 THR A N   1 
ATOM   1730 C CA  . THR A 1 225 ? -24.44771 -1.66019  36.78047  1.000 25.82250 ? 225 THR A CA  1 
ATOM   1731 C C   . THR A 1 225 ? -25.65569 -2.55915  36.96589  1.000 24.33323 ? 225 THR A C   1 
ATOM   1732 O O   . THR A 1 225 ? -25.73681 -3.33413  37.92244  1.000 25.48688 ? 225 THR A O   1 
ATOM   1733 C CB  . THR A 1 225 ? -23.80902 -1.85033  35.39806  1.000 25.35481 ? 225 THR A CB  1 
ATOM   1734 O OG1 . THR A 1 225 ? -24.74101 -1.46400  34.38268  1.000 32.67578 ? 225 THR A OG1 1 
ATOM   1735 C CG2 . THR A 1 225 ? -23.41850 -3.30843  35.19387  1.000 29.08796 ? 225 THR A CG2 1 
ATOM   1736 N N   . THR A 1 226 ? -26.60734 -2.42766  36.05782  1.000 26.51846 ? 226 THR A N   1 
ATOM   1737 C CA  . THR A 1 226 ? -27.78106 -3.28034  36.01267  1.000 23.34549 ? 226 THR A CA  1 
ATOM   1738 C C   . THR A 1 226 ? -27.72389 -4.11715  34.74822  1.000 26.19796 ? 226 THR A C   1 
ATOM   1739 O O   . THR A 1 226 ? -27.00961 -3.79310  33.79730  1.000 23.01804 ? 226 THR A O   1 
ATOM   1740 C CB  . THR A 1 226 ? -29.07572 -2.46196  36.01031  1.000 28.71117 ? 226 THR A CB  1 
ATOM   1741 O OG1 . THR A 1 226 ? -29.20476 -1.79806  34.74908  1.000 29.42292 ? 226 THR A OG1 1 
ATOM   1742 C CG2 . THR A 1 226 ? -29.07069 -1.43530  37.12623  1.000 37.57269 ? 226 THR A CG2 1 
ATOM   1743 N N   . LEU A 1 227 ? -28.51287 -5.19066  34.73348  1.000 25.13569 ? 227 LEU A N   1 
ATOM   1744 C CA  . LEU A 1 227 ? -28.61129 -5.99370  33.52200  1.000 24.55397 ? 227 LEU A CA  1 
ATOM   1745 C C   . LEU A 1 227 ? -29.02559 -5.13919  32.32693  1.000 31.05904 ? 227 LEU A C   1 
ATOM   1746 O O   . LEU A 1 227 ? -28.40575 -5.20158  31.25615  1.000 28.20811 ? 227 LEU A O   1 
ATOM   1747 C CB  . LEU A 1 227 ? -29.58584 -7.14539  33.75233  1.000 28.10822 ? 227 LEU A CB  1 
ATOM   1748 C CG  . LEU A 1 227 ? -29.29658 -8.44403  33.00905  1.000 31.91510 ? 227 LEU A CG  1 
ATOM   1749 C CD1 . LEU A 1 227 ? -27.84484 -8.87564  33.21280  1.000 28.80906 ? 227 LEU A CD1 1 
ATOM   1750 C CD2 . LEU A 1 227 ? -30.22102 -9.51091  33.51821  1.000 21.62390 ? 227 LEU A CD2 1 
ATOM   1751 N N   . ASN A 1 228 ? -30.05602 -4.30216  32.49566  1.000 27.34205 ? 228 ASN A N   1 
ATOM   1752 C CA  . ASN A 1 228 ? -30.52529 -3.51243  31.36197  1.000 34.38156 ? 228 ASN A CA  1 
ATOM   1753 C C   . ASN A 1 228 ? -29.51995 -2.43338  30.97573  1.000 25.55584 ? 228 ASN A C   1 
ATOM   1754 O O   . ASN A 1 228 ? -29.30013 -2.19049  29.78834  1.000 28.25047 ? 228 ASN A O   1 
ATOM   1755 C CB  . ASN A 1 228 ? -31.89646 -2.90926  31.66292  1.000 49.58673 ? 228 ASN A CB  1 
ATOM   1756 C CG  . ASN A 1 228 ? -33.00409 -3.94411  31.59968  1.000 44.71328 ? 228 ASN A CG  1 
ATOM   1757 O OD1 . ASN A 1 228 ? -33.14856 -4.76563  32.50535  1.000 54.18571 ? 228 ASN A OD1 1 
ATOM   1758 N ND2 . ASN A 1 228 ? -33.78308 -3.91886  30.52238  1.000 52.61475 ? 228 ASN A ND2 1 
ATOM   1759 N N   . ASP A 1 229 ? -28.89385 -1.78044  31.95102  1.000 27.37387 ? 229 ASP A N   1 
ATOM   1760 C CA  . ASP A 1 229 ? -27.86984 -0.79522  31.60937  1.000 24.87576 ? 229 ASP A CA  1 
ATOM   1761 C C   . ASP A 1 229 ? -26.72146 -1.45377  30.85380  1.000 22.13486 ? 229 ASP A C   1 
ATOM   1762 O O   . ASP A 1 229 ? -26.32476 -0.99343  29.77337  1.000 26.99376 ? 229 ASP A O   1 
ATOM   1763 C CB  . ASP A 1 229 ? -27.35805 -0.09781  32.86911  1.000 23.83108 ? 229 ASP A CB  1 
ATOM   1764 C CG  . ASP A 1 229 ? -26.21635 0.85746   32.57398  1.000 30.99624 ? 229 ASP A CG  1 
ATOM   1765 O OD1 . ASP A 1 229 ? -26.45224 1.84621   31.84552  1.000 31.24819 ? 229 ASP A OD1 1 
ATOM   1766 O OD2 . ASP A 1 229 ? -25.08684 0.60585   33.05092  1.000 38.21065 ? 229 ASP A OD2 1 
ATOM   1767 N N   . PHE A 1 230 ? -26.19258 -2.55469  31.40306  1.000 22.65851 ? 230 PHE A N   1 
ATOM   1768 C CA  . PHE A 1 230 ? -25.11584 -3.27100  30.72867  1.000 29.04712 ? 230 PHE A CA  1 
ATOM   1769 C C   . PHE A 1 230 ? -25.52306 -3.69346  29.32735  1.000 25.41165 ? 230 PHE A C   1 
ATOM   1770 O O   . PHE A 1 230 ? -24.74048 -3.56370  28.37765  1.000 24.68811 ? 230 PHE A O   1 
ATOM   1771 C CB  . PHE A 1 230 ? -24.69271 -4.50337  31.52006  1.000 22.87020 ? 230 PHE A CB  1 
ATOM   1772 C CG  . PHE A 1 230 ? -23.69515 -5.33283  30.78910  1.000 21.64005 ? 230 PHE A CG  1 
ATOM   1773 C CD1 . PHE A 1 230 ? -22.36189 -4.95975  30.76874  1.000 23.87832 ? 230 PHE A CD1 1 
ATOM   1774 C CD2 . PHE A 1 230 ? -24.10004 -6.44027  30.04391  1.000 25.75918 ? 230 PHE A CD2 1 
ATOM   1775 C CE1 . PHE A 1 230 ? -21.43859 -5.69704  30.05061  1.000 30.51863 ? 230 PHE A CE1 1 
ATOM   1776 C CE2 . PHE A 1 230 ? -23.18011 -7.18572  29.33326  1.000 24.23553 ? 230 PHE A CE2 1 
ATOM   1777 C CZ  . PHE A 1 230 ? -21.85018 -6.81206  29.33253  1.000 31.05595 ? 230 PHE A CZ  1 
ATOM   1778 N N   . ASN A 1 231 ? -26.74055 -4.21690  29.17648  1.000 22.37372 ? 231 ASN A N   1 
ATOM   1779 C CA  . ASN A 1 231 ? -27.17814 -4.65591  27.85537  1.000 25.19220 ? 231 ASN A CA  1 
ATOM   1780 C C   . ASN A 1 231 ? -27.27247 -3.51024  26.85621  1.000 30.22126 ? 231 ASN A C   1 
ATOM   1781 O O   . ASN A 1 231 ? -27.12719 -3.74033  25.65176  1.000 28.27591 ? 231 ASN A O   1 
ATOM   1782 C CB  . ASN A 1 231 ? -28.50371 -5.38946  27.97601  1.000 22.40960 ? 231 ASN A CB  1 
ATOM   1783 C CG  . ASN A 1 231 ? -28.30762 -6.82230  28.37906  1.000 26.54990 ? 231 ASN A CG  1 
ATOM   1784 O OD1 . ASN A 1 231 ? -27.22729 -7.36969  28.17328  1.000 23.62723 ? 231 ASN A OD1 1 
ATOM   1785 N ND2 . ASN A 1 231 ? -29.32690 -7.43682  28.95856  1.000 25.23072 ? 231 ASN A ND2 1 
ATOM   1786 N N   . LEU A 1 232 ? -27.50108 -2.27452  27.31986  1.000 23.98485 ? 232 LEU A N   1 
ATOM   1787 C CA  . LEU A 1 232 ? -27.41965 -1.13822  26.40568  1.000 28.53777 ? 232 LEU A CA  1 
ATOM   1788 C C   . LEU A 1 232 ? -26.00621 -0.98439  25.85894  1.000 29.36352 ? 232 LEU A C   1 
ATOM   1789 O O   . LEU A 1 232 ? -25.81666 -0.66191  24.67827  1.000 30.70571 ? 232 LEU A O   1 
ATOM   1790 C CB  . LEU A 1 232 ? -27.85514 0.15160   27.10640  1.000 31.37682 ? 232 LEU A CB  1 
ATOM   1791 C CG  . LEU A 1 232 ? -29.35118 0.37382   27.33411  1.000 40.07173 ? 232 LEU A CG  1 
ATOM   1792 C CD1 . LEU A 1 232 ? -29.58410 1.76169   27.92281  1.000 42.57918 ? 232 LEU A CD1 1 
ATOM   1793 C CD2 . LEU A 1 232 ? -30.13119 0.19939   26.04311  1.000 38.97917 ? 232 LEU A CD2 1 
ATOM   1794 N N   . VAL A 1 233 ? -25.00221 -1.20298  26.71126  1.000 26.78514 ? 233 VAL A N   1 
ATOM   1795 C CA  . VAL A 1 233 ? -23.61668 -1.16149  26.25704  1.000 27.11222 ? 233 VAL A CA  1 
ATOM   1796 C C   . VAL A 1 233 ? -23.32923 -2.35715  25.36248  1.000 25.19889 ? 233 VAL A C   1 
ATOM   1797 O O   . VAL A 1 233 ? -22.68408 -2.22768  24.31308  1.000 23.84752 ? 233 VAL A O   1 
ATOM   1798 C CB  . VAL A 1 233 ? -22.66109 -1.11668  27.46383  1.000 26.21557 ? 233 VAL A CB  1 
ATOM   1799 C CG1 . VAL A 1 233 ? -21.20689 -1.13413  27.00276  1.000 32.39535 ? 233 VAL A CG1 1 
ATOM   1800 C CG2 . VAL A 1 233 ? -22.94531 0.10960   28.31077  1.000 28.83475 ? 233 VAL A CG2 1 
ATOM   1801 N N   . ALA A 1 234 ? -23.81364 -3.53708  25.76034  1.000 23.89117 ? 234 ALA A N   1 
ATOM   1802 C CA  . ALA A 1 234 ? -23.58494 -4.73879  24.96243  1.000 26.68797 ? 234 ALA A CA  1 
ATOM   1803 C C   . ALA A 1 234 ? -24.06761 -4.54457  23.53247  1.000 27.04459 ? 234 ALA A C   1 
ATOM   1804 O O   . ALA A 1 234 ? -23.35630 -4.87100  22.57710  1.000 23.08787 ? 234 ALA A O   1 
ATOM   1805 C CB  . ALA A 1 234 ? -24.27271 -5.94113  25.60808  1.000 22.00927 ? 234 ALA A CB  1 
ATOM   1806 N N   . MET A 1 235 ? -25.26253 -3.96903  23.36555  1.000 32.76724 ? 235 MET A N   1 
ATOM   1807 C CA  . MET A 1 235 ? -25.79235 -3.74868  22.02312  1.000 30.85542 ? 235 MET A CA  1 
ATOM   1808 C C   . MET A 1 235 ? -24.93467 -2.76176  21.23594  1.000 28.66736 ? 235 MET A C   1 
ATOM   1809 O O   . MET A 1 235 ? -24.69922 -2.95175  20.03690  1.000 31.58042 ? 235 MET A O   1 
ATOM   1810 C CB  . MET A 1 235 ? -27.23824 -3.26221  22.10252  1.000 36.18244 ? 235 MET A CB  1 
ATOM   1811 C CG  . MET A 1 235 ? -27.90192 -3.10233  20.73681  1.000 51.18221 ? 235 MET A CG  1 
ATOM   1812 S SD  . MET A 1 235 ? -29.68677 -2.88328  20.84109  1.000 73.92981 ? 235 MET A SD  1 
ATOM   1813 C CE  . MET A 1 235 ? -29.79297 -1.48204  21.95429  1.000 63.71968 ? 235 MET A CE  1 
ATOM   1814 N N   . LYS A 1 236 ? -24.45501 -1.70294  21.88868  1.000 26.64059 ? 236 LYS A N   1 
ATOM   1815 C CA  . LYS A 1 236 ? -23.61819 -0.73601  21.18891  1.000 24.37815 ? 236 LYS A CA  1 
ATOM   1816 C C   . LYS A 1 236 ? -22.33192 -1.36931  20.67347  1.000 21.16038 ? 236 LYS A C   1 
ATOM   1817 O O   . LYS A 1 236 ? -21.83307 -0.98735  19.61120  1.000 25.67659 ? 236 LYS A O   1 
ATOM   1818 C CB  . LYS A 1 236 ? -23.29582 0.44675   22.10334  1.000 30.97643 ? 236 LYS A CB  1 
ATOM   1819 C CG  . LYS A 1 236 ? -22.26073 1.38393   21.52261  1.000 34.57834 ? 236 LYS A CG  1 
ATOM   1820 C CD  . LYS A 1 236 ? -22.31412 2.75272   22.16347  1.000 52.22803 ? 236 LYS A CD  1 
ATOM   1821 C CE  . LYS A 1 236 ? -21.32878 3.70104   21.49829  1.000 36.07805 ? 236 LYS A CE  1 
ATOM   1822 N NZ  . LYS A 1 236 ? -21.40544 5.05838   22.09460  1.000 50.49600 ? 236 LYS A NZ  1 
ATOM   1823 N N   . TYR A 1 237 ? -21.78744 -2.34134  21.40125  1.000 25.76046 ? 237 TYR A N   1 
ATOM   1824 C CA  . TYR A 1 237 ? -20.50332 -2.93066  21.05238  1.000 22.93144 ? 237 TYR A CA  1 
ATOM   1825 C C   . TYR A 1 237 ? -20.63401 -4.30714  20.41808  1.000 24.36660 ? 237 TYR A C   1 
ATOM   1826 O O   . TYR A 1 237 ? -19.63091 -5.01115  20.28079  1.000 20.24306 ? 237 TYR A O   1 
ATOM   1827 C CB  . TYR A 1 237 ? -19.60731 -2.97878  22.29385  1.000 19.20023 ? 237 TYR A CB  1 
ATOM   1828 C CG  . TYR A 1 237 ? -19.12568 -1.58258  22.64841  1.000 23.22593 ? 237 TYR A CG  1 
ATOM   1829 C CD1 . TYR A 1 237 ? -18.02911 -1.02783  21.99221  1.000 29.11454 ? 237 TYR A CD1 1 
ATOM   1830 C CD2 . TYR A 1 237 ? -19.80562 -0.80176  23.57889  1.000 27.26018 ? 237 TYR A CD2 1 
ATOM   1831 C CE1 . TYR A 1 237 ? -17.59805 0.25623   22.27567  1.000 26.91330 ? 237 TYR A CE1 1 
ATOM   1832 C CE2 . TYR A 1 237 ? -19.38445 0.48886   23.87207  1.000 28.25638 ? 237 TYR A CE2 1 
ATOM   1833 C CZ  . TYR A 1 237 ? -18.27685 1.00721   23.22166  1.000 28.89024 ? 237 TYR A CZ  1 
ATOM   1834 O OH  . TYR A 1 237 ? -17.84965 2.28694   23.50204  1.000 29.62581 ? 237 TYR A OH  1 
ATOM   1835 N N   . ASN A 1 238 ? -21.83868 -4.69066  20.00358  1.000 17.91788 ? 238 ASN A N   1 
ATOM   1836 C CA  . ASN A 1 238 ? -22.06753 -5.94294  19.27652  1.000 17.03806 ? 238 ASN A CA  1 
ATOM   1837 C C   . ASN A 1 238 ? -21.69056 -7.14904  20.13369  1.000 20.04209 ? 238 ASN A C   1 
ATOM   1838 O O   . ASN A 1 238 ? -21.03588 -8.08294  19.66760  1.000 23.48882 ? 238 ASN A O   1 
ATOM   1839 C CB  . ASN A 1 238 ? -21.31079 -5.95544  17.94302  1.000 24.28461 ? 238 ASN A CB  1 
ATOM   1840 C CG  . ASN A 1 238 ? -21.64464 -4.74235  17.08223  1.000 44.12408 ? 238 ASN A CG  1 
ATOM   1841 O OD1 . ASN A 1 238 ? -20.75461 -4.01525  16.63338  1.000 46.86741 ? 238 ASN A OD1 1 
ATOM   1842 N ND2 . ASN A 1 238 ? -22.93610 -4.50943  16.86672  1.000 38.09620 ? 238 ASN A ND2 1 
ATOM   1843 N N   . TYR A 1 239 ? -22.08492 -7.10051  21.39729  1.000 19.03094 ? 239 TYR A N   1 
ATOM   1844 C CA  . TYR A 1 239 ? -22.00294 -8.21519  22.32877  1.000 17.51103 ? 239 TYR A CA  1 
ATOM   1845 C C   . TYR A 1 239 ? -23.37783 -8.84880  22.46559  1.000 17.32073 ? 239 TYR A C   1 
ATOM   1846 O O   . TYR A 1 239 ? -24.39830 -8.15734  22.40965  1.000 23.59865 ? 239 TYR A O   1 
ATOM   1847 C CB  . TYR A 1 239 ? -21.51624 -7.74507  23.71054  1.000 17.50444 ? 239 TYR A CB  1 
ATOM   1848 C CG  . TYR A 1 239 ? -20.01898 -7.75517  23.90286  1.000 16.03778 ? 239 TYR A CG  1 
ATOM   1849 C CD1 . TYR A 1 239 ? -19.17879 -7.07711  23.04424  1.000 14.77235 ? 239 TYR A CD1 1 
ATOM   1850 C CD2 . TYR A 1 239 ? -19.45185 -8.41363  24.99194  1.000 19.38569 ? 239 TYR A CD2 1 
ATOM   1851 C CE1 . TYR A 1 239 ? -17.80758 -7.09251  23.21405  1.000 19.76741 ? 239 TYR A CE1 1 
ATOM   1852 C CE2 . TYR A 1 239 ? -18.07718 -8.43250  25.18377  1.000 19.07331 ? 239 TYR A CE2 1 
ATOM   1853 C CZ  . TYR A 1 239 ? -17.26547 -7.76630  24.29853  1.000 19.09910 ? 239 TYR A CZ  1 
ATOM   1854 O OH  . TYR A 1 239 ? -15.90008 -7.77358  24.47888  1.000 18.66571 ? 239 TYR A OH  1 
ATOM   1855 N N   . GLU A 1 240 ? -23.40226 -10.16860 22.64800  1.000 17.90685 ? 240 GLU A N   1 
ATOM   1856 C CA  . GLU A 1 240 ? -24.66172 -10.85625 22.91723  1.000 23.34357 ? 240 GLU A CA  1 
ATOM   1857 C C   . GLU A 1 240 ? -25.32924 -10.26900 24.15989  1.000 19.92077 ? 240 GLU A C   1 
ATOM   1858 O O   . GLU A 1 240 ? -24.65137 -9.97015  25.14406  1.000 19.40166 ? 240 GLU A O   1 
ATOM   1859 C CB  . GLU A 1 240 ? -24.42678 -12.35510 23.13435  1.000 21.75127 ? 240 GLU A CB  1 
ATOM   1860 C CG  . GLU A 1 240 ? -24.07337 -13.11536 21.87701  1.000 29.57218 ? 240 GLU A CG  1 
ATOM   1861 C CD  . GLU A 1 240 ? -25.26044 -13.28004 20.95138  1.000 57.49536 ? 240 GLU A CD  1 
ATOM   1862 O OE1 . GLU A 1 240 ? -26.25465 -13.91253 21.36554  1.000 56.26142 ? 240 GLU A OE1 1 
ATOM   1863 O OE2 . GLU A 1 240 ? -25.20372 -12.76305 19.81463  1.000 43.49323 ? 240 GLU A OE2 1 
ATOM   1864 N N   . PRO A 1 241 ? -26.64781 -10.08980 24.15189  1.000 21.69720 ? 241 PRO A N   1 
ATOM   1865 C CA  . PRO A 1 241 ? -27.32580 -9.64093  25.37630  1.000 22.52959 ? 241 PRO A CA  1 
ATOM   1866 C C   . PRO A 1 241 ? -27.14406 -10.64728 26.50483  1.000 18.81744 ? 241 PRO A C   1 
ATOM   1867 O O   . PRO A 1 241 ? -27.26044 -11.85546 26.30663  1.000 20.25862 ? 241 PRO A O   1 
ATOM   1868 C CB  . PRO A 1 241 ? -28.79665 -9.54325  24.95424  1.000 24.40026 ? 241 PRO A CB  1 
ATOM   1869 C CG  . PRO A 1 241 ? -28.75705 -9.41026  23.45131  1.000 25.98152 ? 241 PRO A CG  1 
ATOM   1870 C CD  . PRO A 1 241 ? -27.55898 -10.18934 22.99904  1.000 26.46281 ? 241 PRO A CD  1 
ATOM   1871 N N   . LEU A 1 242 ? -26.86996 -10.13658 27.70303  1.000 20.41541 ? 242 LEU A N   1 
ATOM   1872 C CA  . LEU A 1 242 ? -26.73357 -11.00467 28.86535  1.000 23.12329 ? 242 LEU A CA  1 
ATOM   1873 C C   . LEU A 1 242 ? -28.10524 -11.27716 29.46761  1.000 25.26104 ? 242 LEU A C   1 
ATOM   1874 O O   . LEU A 1 242 ? -28.91017 -10.35899 29.64696  1.000 22.37841 ? 242 LEU A O   1 
ATOM   1875 C CB  . LEU A 1 242 ? -25.81333 -10.37705 29.90784  1.000 19.70683 ? 242 LEU A CB  1 
ATOM   1876 C CG  . LEU A 1 242 ? -25.19742 -11.32275 30.95289  1.000 19.98281 ? 242 LEU A CG  1 
ATOM   1877 C CD1 . LEU A 1 242 ? -24.13039 -12.18692 30.28760  1.000 21.10269 ? 242 LEU A CD1 1 
ATOM   1878 C CD2 . LEU A 1 242 ? -24.61109 -10.51049 32.07213  1.000 23.33379 ? 242 LEU A CD2 1 
ATOM   1879 N N   . THR A 1 243 ? -28.37604 -12.54357 29.75070  1.000 21.71667 ? 243 THR A N   1 
ATOM   1880 C CA  . THR A 1 243 ? -29.61736 -12.96403 30.38056  1.000 19.83538 ? 243 THR A CA  1 
ATOM   1881 C C   . THR A 1 243 ? -29.34780 -13.45894 31.79446  1.000 25.59378 ? 243 THR A C   1 
ATOM   1882 O O   . THR A 1 243 ? -28.19801 -13.62710 32.21694  1.000 20.52676 ? 243 THR A O   1 
ATOM   1883 C CB  . THR A 1 243 ? -30.28280 -14.07953 29.58370  1.000 17.98236 ? 243 THR A CB  1 
ATOM   1884 O OG1 . THR A 1 243 ? -29.47430 -15.25491 29.68268  1.000 21.39140 ? 243 THR A OG1 1 
ATOM   1885 C CG2 . THR A 1 243 ? -30.44896 -13.68875 28.10806  1.000 21.79202 ? 243 THR A CG2 1 
ATOM   1886 N N   . GLN A 1 244 ? -30.43712 -13.68799 32.53118  1.000 20.69892 ? 244 GLN A N   1 
ATOM   1887 C CA  . GLN A 1 244 ? -30.30225 -14.27846 33.86002  1.000 14.90055 ? 244 GLN A CA  1 
ATOM   1888 C C   . GLN A 1 244 ? -29.74176 -15.68866 33.78886  1.000 17.48190 ? 244 GLN A C   1 
ATOM   1889 O O   . GLN A 1 244 ? -29.05029 -16.12768 34.71524  1.000 18.92957 ? 244 GLN A O   1 
ATOM   1890 C CB  . GLN A 1 244 ? -31.65326 -14.31301 34.57659  1.000 17.78935 ? 244 GLN A CB  1 
ATOM   1891 C CG  . GLN A 1 244 ? -31.55581 -14.81600 36.01481  1.000 16.78932 ? 244 GLN A CG  1 
ATOM   1892 C CD  . GLN A 1 244 ? -30.70829 -13.90637 36.84761  1.000 19.93481 ? 244 GLN A CD  1 
ATOM   1893 O OE1 . GLN A 1 244 ? -30.81083 -12.67919 36.74455  1.000 22.96468 ? 244 GLN A OE1 1 
ATOM   1894 N NE2 . GLN A 1 244 ? -29.84833 -14.49275 37.68607  1.000 18.04683 ? 244 GLN A NE2 1 
ATOM   1895 N N   . ASP A 1 245 ? -30.06768 -16.42684 32.73064  1.000 20.35632 ? 245 ASP A N   1 
ATOM   1896 C CA  . ASP A 1 245 ? -29.47841 -17.74520 32.53349  1.000 19.86181 ? 245 ASP A CA  1 
ATOM   1897 C C   . ASP A 1 245 ? -27.95889 -17.66314 32.48427  1.000 16.93962 ? 245 ASP A C   1 
ATOM   1898 O O   . ASP A 1 245 ? -27.26915 -18.52680 33.03720  1.000 18.59018 ? 245 ASP A O   1 
ATOM   1899 C CB  . ASP A 1 245 ? -30.00793 -18.37574 31.24090  1.000 19.48519 ? 245 ASP A CB  1 
ATOM   1900 C CG  . ASP A 1 245 ? -31.39620 -18.96681 31.38776  1.000 36.83505 ? 245 ASP A CG  1 
ATOM   1901 O OD1 . ASP A 1 245 ? -31.90542 -19.04026 32.51959  1.000 33.54149 ? 245 ASP A OD1 1 
ATOM   1902 O OD2 . ASP A 1 245 ? -31.97881 -19.36293 30.35290  1.000 42.62121 ? 245 ASP A OD2 1 
ATOM   1903 N N   . HIS A 1 246 ? -27.41756 -16.64380 31.81336  1.000 19.00237 ? 246 HIS A N   1 
ATOM   1904 C CA  . HIS A 1 246 ? -25.96577 -16.44552 31.80132  1.000 19.28337 ? 246 HIS A CA  1 
ATOM   1905 C C   . HIS A 1 246 ? -25.44921 -16.10560 33.19659  1.000 18.48964 ? 246 HIS A C   1 
ATOM   1906 O O   . HIS A 1 246 ? -24.41330 -16.63081 33.63539  1.000 19.07891 ? 246 HIS A O   1 
ATOM   1907 C CB  . HIS A 1 246 ? -25.57698 -15.32624 30.83176  1.000 19.24464 ? 246 HIS A CB  1 
ATOM   1908 C CG  . HIS A 1 246 ? -25.95132 -15.58835 29.40942  1.000 23.54828 ? 246 HIS A CG  1 
ATOM   1909 N ND1 . HIS A 1 246 ? -26.39521 -14.59118 28.56609  1.000 25.77637 ? 246 HIS A ND1 1 
ATOM   1910 C CD2 . HIS A 1 246 ? -25.93644 -16.72722 28.67567  1.000 21.00179 ? 246 HIS A CD2 1 
ATOM   1911 C CE1 . HIS A 1 246 ? -26.64868 -15.10924 27.37579  1.000 21.42680 ? 246 HIS A CE1 1 
ATOM   1912 N NE2 . HIS A 1 246 ? -26.38008 -16.40277 27.41532  1.000 23.30414 ? 246 HIS A NE2 1 
ATOM   1913 N N   . VAL A 1 247 ? -26.14280 -15.20350 33.89503  1.000 17.57877 ? 247 VAL A N   1 
ATOM   1914 C CA  . VAL A 1 247 ? -25.77013 -14.85569 35.26339  1.000 15.38930 ? 247 VAL A CA  1 
ATOM   1915 C C   . VAL A 1 247 ? -25.73963 -16.10381 36.14081  1.000 16.73505 ? 247 VAL A C   1 
ATOM   1916 O O   . VAL A 1 247 ? -24.82189 -16.28691 36.95347  1.000 19.67502 ? 247 VAL A O   1 
ATOM   1917 C CB  . VAL A 1 247 ? -26.73519 -13.79076 35.82681  1.000 18.35333 ? 247 VAL A CB  1 
ATOM   1918 C CG1 . VAL A 1 247 ? -26.41727 -13.56081 37.29459  1.000 17.41411 ? 247 VAL A CG1 1 
ATOM   1919 C CG2 . VAL A 1 247 ? -26.59748 -12.49269 35.05788  1.000 21.34862 ? 247 VAL A CG2 1 
ATOM   1920 N N   . ASP A 1 248 ? -26.73552 -16.98623 35.98231  1.000 16.39287 ? 248 ASP A N   1 
ATOM   1921 C CA  . ASP A 1 248 ? -26.80485 -18.20972 36.77785  1.000 20.86343 ? 248 ASP A CA  1 
ATOM   1922 C C   . ASP A 1 248 ? -25.62582 -19.12478 36.49022  1.000 22.11024 ? 248 ASP A C   1 
ATOM   1923 O O   . ASP A 1 248 ? -25.06633 -19.73846 37.40786  1.000 17.87500 ? 248 ASP A O   1 
ATOM   1924 C CB  . ASP A 1 248 ? -28.10906 -18.95383 36.48676  1.000 19.93560 ? 248 ASP A CB  1 
ATOM   1925 C CG  . ASP A 1 248 ? -29.33427 -18.25460 37.04825  1.000 19.80384 ? 248 ASP A CG  1 
ATOM   1926 O OD1 . ASP A 1 248 ? -29.18427 -17.42581 37.95756  1.000 22.40402 ? 248 ASP A OD1 1 
ATOM   1927 O OD2 . ASP A 1 248 ? -30.45175 -18.57371 36.58253  1.000 25.55743 ? 248 ASP A OD2 1 
ATOM   1928 N N   . ILE A 1 249 ? -25.25592 -19.25904 35.21629  1.000 20.15743 ? 249 ILE A N   1 
ATOM   1929 C CA  . ILE A 1 249 ? -24.13385 -20.12884 34.86124  1.000 22.47769 ? 249 ILE A CA  1 
ATOM   1930 C C   . ILE A 1 249 ? -22.82418 -19.56538 35.39799  1.000 20.49373 ? 249 ILE A C   1 
ATOM   1931 O O   . ILE A 1 249 ? -21.88133 -20.31757 35.69035  1.000 21.43889 ? 249 ILE A O   1 
ATOM   1932 C CB  . ILE A 1 249 ? -24.10624 -20.33043 33.33200  1.000 22.34766 ? 249 ILE A CB  1 
ATOM   1933 C CG1 . ILE A 1 249 ? -25.26810 -21.22783 32.91757  1.000 25.02173 ? 249 ILE A CG1 1 
ATOM   1934 C CG2 . ILE A 1 249 ? -22.79698 -20.95370 32.88856  1.000 34.55079 ? 249 ILE A CG2 1 
ATOM   1935 C CD1 . ILE A 1 249 ? -25.57333 -21.19233 31.43127  1.000 30.90894 ? 249 ILE A CD1 1 
ATOM   1936 N N   . LEU A 1 250 ? -22.74047 -18.25356 35.56694  1.000 19.29695 ? 250 LEU A N   1 
ATOM   1937 C CA  . LEU A 1 250 ? -21.54794 -17.65920 36.14727  1.000 15.33161 ? 250 LEU A CA  1 
ATOM   1938 C C   . LEU A 1 250 ? -21.52240 -17.75147 37.66727  1.000 16.34924 ? 250 LEU A C   1 
ATOM   1939 O O   . LEU A 1 250 ? -20.55582 -17.28622 38.27405  1.000 21.23518 ? 250 LEU A O   1 
ATOM   1940 C CB  . LEU A 1 250 ? -21.43337 -16.19303 35.71877  1.000 18.22462 ? 250 LEU A CB  1 
ATOM   1941 C CG  . LEU A 1 250 ? -21.08211 -16.00023 34.23984  1.000 18.22336 ? 250 LEU A CG  1 
ATOM   1942 C CD1 . LEU A 1 250 ? -21.35291 -14.54805 33.84273  1.000 13.18329 ? 250 LEU A CD1 1 
ATOM   1943 C CD2 . LEU A 1 250 ? -19.60200 -16.36642 33.99043  1.000 15.19406 ? 250 LEU A CD2 1 
ATOM   1944 N N   . GLY A 1 251 ? -22.55967 -18.31596 38.28056  1.000 16.63470 ? 251 GLY A N   1 
ATOM   1945 C CA  . GLY A 1 251 ? -22.70573 -18.34426 39.71936  1.000 24.89467 ? 251 GLY A CA  1 
ATOM   1946 C C   . GLY A 1 251 ? -21.50736 -18.89442 40.46531  1.000 22.52502 ? 251 GLY A C   1 
ATOM   1947 O O   . GLY A 1 251 ? -20.96544 -18.23889 41.36186  1.000 21.79828 ? 251 GLY A O   1 
ATOM   1948 N N   . PRO A 1 252 ? -21.07409 -20.11351 40.11921  1.000 19.72318 ? 252 PRO A N   1 
ATOM   1949 C CA  . PRO A 1 252 ? -19.89748 -20.68259 40.80709  1.000 23.87004 ? 252 PRO A CA  1 
ATOM   1950 C C   . PRO A 1 252 ? -18.65107 -19.80812 40.73285  1.000 26.14968 ? 252 PRO A C   1 
ATOM   1951 O O   . PRO A 1 252 ? -17.91989 -19.69684 41.72645  1.000 22.23466 ? 252 PRO A O   1 
ATOM   1952 C CB  . PRO A 1 252 ? -19.70867 -22.02344 40.09260  1.000 23.81737 ? 252 PRO A CB  1 
ATOM   1953 C CG  . PRO A 1 252 ? -21.10376 -22.42112 39.71636  1.000 27.25870 ? 252 PRO A CG  1 
ATOM   1954 C CD  . PRO A 1 252 ? -21.78200 -21.12638 39.32131  1.000 23.33146 ? 252 PRO A CD  1 
ATOM   1955 N N   . LEU A 1 253 ? -18.38979 -19.16477 39.59185  1.000 21.29712 ? 253 LEU A N   1 
ATOM   1956 C CA  . LEU A 1 253 ? -17.22936 -18.28379 39.49478  1.000 16.83583 ? 253 LEU A CA  1 
ATOM   1957 C C   . LEU A 1 253 ? -17.40361 -17.03832 40.35369  1.000 23.21496 ? 253 LEU A C   1 
ATOM   1958 O O   . LEU A 1 253 ? -16.44439 -16.55739 40.96715  1.000 24.32323 ? 253 LEU A O   1 
ATOM   1959 C CB  . LEU A 1 253 ? -16.97089 -17.89837 38.03088  1.000 19.39508 ? 253 LEU A CB  1 
ATOM   1960 C CG  . LEU A 1 253 ? -16.50923 -19.06528 37.14884  1.000 20.49629 ? 253 LEU A CG  1 
ATOM   1961 C CD1 . LEU A 1 253 ? -16.32477 -18.59188 35.71105  1.000 20.08519 ? 253 LEU A CD1 1 
ATOM   1962 C CD2 . LEU A 1 253 ? -15.23064 -19.69310 37.69411  1.000 22.86692 ? 253 LEU A CD2 1 
ATOM   1963 N N   . SER A 1 254 ? -18.61810 -16.49301 40.41336  1.000 19.22968 ? 254 SER A N   1 
ATOM   1964 C CA  A SER A 1 254 ? -18.87567 -15.36455 41.30070  0.600 23.64414 ? 254 SER A CA  1 
ATOM   1965 C CA  B SER A 1 254 ? -18.86114 -15.36168 41.29965  0.400 23.60820 ? 254 SER A CA  1 
ATOM   1966 C C   . SER A 1 254 ? -18.65672 -15.76079 42.75599  1.000 22.26537 ? 254 SER A C   1 
ATOM   1967 O O   . SER A 1 254 ? -18.05547 -15.00792 43.53296  1.000 29.11430 ? 254 SER A O   1 
ATOM   1968 C CB  A SER A 1 254 ? -20.30439 -14.85228 41.08801  0.600 26.02311 ? 254 SER A CB  1 
ATOM   1969 C CB  B SER A 1 254 ? -20.27182 -14.80967 41.08113  0.400 26.06313 ? 254 SER A CB  1 
ATOM   1970 O OG  A SER A 1 254 ? -20.53272 -13.63627 41.78586  0.600 21.81305 ? 254 SER A OG  1 
ATOM   1971 O OG  B SER A 1 254 ? -21.25621 -15.69441 41.57750  0.400 24.79620 ? 254 SER A OG  1 
ATOM   1972 N N   . ALA A 1 255 ? -19.13337 -16.94881 43.13536  1.000 18.60763 ? 255 ALA A N   1 
ATOM   1973 C CA  . ALA A 1 255 ? -18.96692 -17.42092 44.50555  1.000 23.93213 ? 255 ALA A CA  1 
ATOM   1974 C C   . ALA A 1 255 ? -17.49448 -17.60391 44.85075  1.000 37.10686 ? 255 ALA A C   1 
ATOM   1975 O O   . ALA A 1 255 ? -17.04587 -17.18028 45.92189  1.000 31.19309 ? 255 ALA A O   1 
ATOM   1976 C CB  . ALA A 1 255 ? -19.72847 -18.72658 44.70457  1.000 24.16794 ? 255 ALA A CB  1 
ATOM   1977 N N   . GLN A 1 256 ? -16.72972 -18.23287 43.95608  1.000 28.84227 ? 256 GLN A N   1 
ATOM   1978 C CA  . GLN A 1 256 ? -15.31424 -18.47674 44.22730  1.000 23.81501 ? 256 GLN A CA  1 
ATOM   1979 C C   . GLN A 1 256 ? -14.55405 -17.17375 44.43596  1.000 32.02030 ? 256 GLN A C   1 
ATOM   1980 O O   . GLN A 1 256 ? -13.71250 -17.07434 45.33757  1.000 40.28022 ? 256 GLN A O   1 
ATOM   1981 C CB  . GLN A 1 256 ? -14.70080 -19.28391 43.08708  1.000 36.21686 ? 256 GLN A CB  1 
ATOM   1982 C CG  . GLN A 1 256 ? -13.21790 -19.55199 43.24507  1.000 39.78401 ? 256 GLN A CG  1 
ATOM   1983 C CD  . GLN A 1 256 ? -12.64612 -20.32350 42.07420  1.000 44.89616 ? 256 GLN A CD  1 
ATOM   1984 O OE1 . GLN A 1 256 ? -13.38543 -20.89717 41.27084  1.000 45.95219 ? 256 GLN A OE1 1 
ATOM   1985 N NE2 . GLN A 1 256 ? -11.32308 -20.33950 41.96672  1.000 42.88864 ? 256 GLN A NE2 1 
ATOM   1986 N N   . THR A 1 257 ? -14.84762 -16.15576 43.63191  1.000 24.50184 ? 257 THR A N   1 
ATOM   1987 C CA  . THR A 1 257 ? -14.08803 -14.91392 43.66753  1.000 22.04755 ? 257 THR A CA  1 
ATOM   1988 C C   . THR A 1 257 ? -14.70299 -13.85230 44.56445  1.000 27.79115 ? 257 THR A C   1 
ATOM   1989 O O   . THR A 1 257 ? -14.06257 -12.82255 44.80105  1.000 25.00828 ? 257 THR A O   1 
ATOM   1990 C CB  . THR A 1 257 ? -13.93400 -14.34243 42.24963  1.000 40.75751 ? 257 THR A CB  1 
ATOM   1991 O OG1 . THR A 1 257 ? -15.22185 -13.98067 41.71862  1.000 27.55959 ? 257 THR A OG1 1 
ATOM   1992 C CG2 . THR A 1 257 ? -13.27759 -15.37790 41.34069  1.000 26.13013 ? 257 THR A CG2 1 
ATOM   1993 N N   . GLY A 1 258 ? -15.93239 -14.05325 45.03015  1.000 23.26603 ? 258 GLY A N   1 
ATOM   1994 C CA  . GLY A 1 258 ? -16.61177 -12.98756 45.72983  1.000 21.05633 ? 258 GLY A CA  1 
ATOM   1995 C C   . GLY A 1 258 ? -16.94195 -11.76178 44.91296  1.000 29.49977 ? 258 GLY A C   1 
ATOM   1996 O O   . GLY A 1 258 ? -17.17535 -10.70361 45.49372  1.000 29.38181 ? 258 GLY A O   1 
ATOM   1997 N N   . ILE A 1 259 ? -16.99083 -11.85234 43.58316  1.000 20.74497 ? 259 ILE A N   1 
ATOM   1998 C CA  . ILE A 1 259 ? -17.28940 -10.68371 42.76314  1.000 25.16461 ? 259 ILE A CA  1 
ATOM   1999 C C   . ILE A 1 259 ? -18.64536 -10.90767 42.11489  1.000 26.96534 ? 259 ILE A C   1 
ATOM   2000 O O   . ILE A 1 259 ? -18.80383 -11.81487 41.28670  1.000 27.41819 ? 259 ILE A O   1 
ATOM   2001 C CB  . ILE A 1 259 ? -16.20900 -10.42207 41.71134  1.000 29.61183 ? 259 ILE A CB  1 
ATOM   2002 C CG1 . ILE A 1 259 ? -14.90434 -10.02205 42.39926  1.000 31.20694 ? 259 ILE A CG1 1 
ATOM   2003 C CG2 . ILE A 1 259 ? -16.67734 -9.34837  40.73687  1.000 26.32691 ? 259 ILE A CG2 1 
ATOM   2004 C CD1 . ILE A 1 259 ? -13.77397 -9.78087  41.44156  1.000 34.61706 ? 259 ILE A CD1 1 
ATOM   2005 N N   . ALA A 1 260 ? -19.62804 -10.08909 42.49788  1.000 23.90648 ? 260 ALA A N   1 
ATOM   2006 C CA  . ALA A 1 260 ? -20.97439 -10.24501 41.96213  1.000 27.24887 ? 260 ALA A CA  1 
ATOM   2007 C C   . ALA A 1 260 ? -20.96194 -10.08297 40.44610  1.000 19.79073 ? 260 ALA A C   1 
ATOM   2008 O O   . ALA A 1 260 ? -20.21958 -9.25917  39.90026  1.000 22.10488 ? 260 ALA A O   1 
ATOM   2009 C CB  . ALA A 1 260 ? -21.92014 -9.22405  42.60340  1.000 25.17363 ? 260 ALA A CB  1 
ATOM   2010 N N   . VAL A 1 261 ? -21.79091 -10.87950 39.76926  1.000 22.42108 ? 261 VAL A N   1 
ATOM   2011 C CA  . VAL A 1 261 ? -21.81653 -10.86817 38.30229  1.000 19.97547 ? 261 VAL A CA  1 
ATOM   2012 C C   . VAL A 1 261 ? -22.03419 -9.45619  37.76508  1.000 24.38520 ? 261 VAL A C   1 
ATOM   2013 O O   . VAL A 1 261 ? -21.38685 -9.03917  36.79488  1.000 19.28191 ? 261 VAL A O   1 
ATOM   2014 C CB  . VAL A 1 261 ? -22.88004 -11.85175 37.77478  1.000 24.79288 ? 261 VAL A CB  1 
ATOM   2015 C CG1 . VAL A 1 261 ? -22.97515 -11.76518 36.25133  1.000 17.98780 ? 261 VAL A CG1 1 
ATOM   2016 C CG2 . VAL A 1 261 ? -22.55531 -13.29720 38.18236  1.000 25.72390 ? 261 VAL A CG2 1 
ATOM   2017 N N   . LEU A 1 262 ? -22.93695 -8.68282  38.38800  1.000 20.47429 ? 262 LEU A N   1 
ATOM   2018 C CA  . LEU A 1 262 ? -23.20184 -7.34628  37.85941  1.000 18.58507 ? 262 LEU A CA  1 
ATOM   2019 C C   . LEU A 1 262 ? -22.04377 -6.39275  38.11362  1.000 19.66856 ? 262 LEU A C   1 
ATOM   2020 O O   . LEU A 1 262 ? -21.83759 -5.45265  37.33837  1.000 23.51642 ? 262 LEU A O   1 
ATOM   2021 C CB  . LEU A 1 262 ? -24.49940 -6.79540  38.44512  1.000 24.11569 ? 262 LEU A CB  1 
ATOM   2022 C CG  . LEU A 1 262 ? -25.74166 -7.49966  37.89309  1.000 19.52977 ? 262 LEU A CG  1 
ATOM   2023 C CD1 . LEU A 1 262 ? -26.99136 -6.95746  38.55704  1.000 25.47456 ? 262 LEU A CD1 1 
ATOM   2024 C CD2 . LEU A 1 262 ? -25.83605 -7.33485  36.37499  1.000 23.07195 ? 262 LEU A CD2 1 
ATOM   2025 N N   . ASP A 1 263 ? -21.27915 -6.61435  39.18329  1.000 21.59736 ? 263 ASP A N   1 
ATOM   2026 C CA  . ASP A 1 263 ? -20.04291 -5.85855  39.35596  1.000 20.03497 ? 263 ASP A CA  1 
ATOM   2027 C C   . ASP A 1 263 ? -19.05184 -6.18216  38.23988  1.000 26.93364 ? 263 ASP A C   1 
ATOM   2028 O O   . ASP A 1 263 ? -18.42830 -5.27923  37.67100  1.000 24.97749 ? 263 ASP A O   1 
ATOM   2029 C CB  . ASP A 1 263 ? -19.43587 -6.14813  40.72837  1.000 22.64298 ? 263 ASP A CB  1 
ATOM   2030 C CG  . ASP A 1 263 ? -20.25790 -5.55977  41.87392  1.000 25.69114 ? 263 ASP A CG  1 
ATOM   2031 O OD1 . ASP A 1 263 ? -21.32026 -4.94439  41.62555  1.000 26.57964 ? 263 ASP A OD1 1 
ATOM   2032 O OD2 . ASP A 1 263 ? -19.82554 -5.72034  43.03084  1.000 26.52639 ? 263 ASP A OD2 1 
ATOM   2033 N N   . MET A 1 264 ? -18.89323 -7.47172  37.90820  1.000 23.79956 ? 264 MET A N   1 
ATOM   2034 C CA  . MET A 1 264 ? -18.01885 -7.82199  36.78538  1.000 20.94137 ? 264 MET A CA  1 
ATOM   2035 C C   . MET A 1 264 ? -18.52860 -7.21428  35.48386  1.000 20.64517 ? 264 MET A C   1 
ATOM   2036 O O   . MET A 1 264 ? -17.73025 -6.79548  34.63594  1.000 21.84566 ? 264 MET A O   1 
ATOM   2037 C CB  . MET A 1 264 ? -17.87967 -9.34411  36.64391  1.000 23.89721 ? 264 MET A CB  1 
ATOM   2038 C CG  . MET A 1 264 ? -16.70247 -9.77849  35.75175  1.000 20.27866 ? 264 MET A CG  1 
ATOM   2039 S SD  . MET A 1 264 ? -15.08434 -9.24616  36.37369  1.000 23.57867 ? 264 MET A SD  1 
ATOM   2040 C CE  . MET A 1 264 ? -14.67322 -10.65888 37.36760  1.000 20.73482 ? 264 MET A CE  1 
ATOM   2041 N N   . CYS A 1 265 ? -19.84855 -7.11828  35.32224  1.000 21.25769 ? 265 CYS A N   1 
ATOM   2042 C CA  . CYS A 1 265 ? -20.41106 -6.45375  34.14771  1.000 23.06131 ? 265 CYS A CA  1 
ATOM   2043 C C   . CYS A 1 265 ? -20.01009 -4.98364  34.08662  1.000 20.78246 ? 265 CYS A C   1 
ATOM   2044 O O   . CYS A 1 265 ? -19.75684 -4.44768  33.00393  1.000 21.43474 ? 265 CYS A O   1 
ATOM   2045 C CB  . CYS A 1 265 ? -21.93371 -6.59316  34.14473  1.000 22.46052 ? 265 CYS A CB  1 
ATOM   2046 S SG  . CYS A 1 265 ? -22.53975 -8.25334  33.77133  1.000 21.89148 ? 265 CYS A SG  1 
ATOM   2047 N N   . ALA A 1 266 ? -19.93158 -4.31402  35.24633  1.000 25.06322 ? 266 ALA A N   1 
ATOM   2048 C CA  . ALA A 1 266 ? -19.52084 -2.91521  35.25135  1.000 19.87326 ? 266 ALA A CA  1 
ATOM   2049 C C   . ALA A 1 266 ? -18.05543 -2.76138  34.89067  1.000 22.35397 ? 266 ALA A C   1 
ATOM   2050 O O   . ALA A 1 266 ? -17.68400 -1.78865  34.22588  1.000 25.12345 ? 266 ALA A O   1 
ATOM   2051 C CB  . ALA A 1 266 ? -19.78954 -2.27882  36.61495  1.000 27.61166 ? 266 ALA A CB  1 
ATOM   2052 N N   . SER A 1 267 ? -17.21448 -3.70545  35.31185  1.000 24.26471 ? 267 SER A N   1 
ATOM   2053 C CA  . SER A 1 267 ? -15.84005 -3.72510  34.82410  1.000 28.04654 ? 267 SER A CA  1 
ATOM   2054 C C   . SER A 1 267 ? -15.80332 -3.89183  33.30868  1.000 20.66800 ? 267 SER A C   1 
ATOM   2055 O O   . SER A 1 267 ? -15.07081 -3.17553  32.60926  1.000 22.96837 ? 267 SER A O   1 
ATOM   2056 C CB  . SER A 1 267 ? -15.06395 -4.84520  35.51366  1.000 32.15555 ? 267 SER A CB  1 
ATOM   2057 O OG  . SER A 1 267 ? -14.73509 -4.47322  36.84605  1.000 32.90472 ? 267 SER A OG  1 
ATOM   2058 N N   . LEU A 1 268 ? -16.57392 -4.84852  32.78522  1.000 22.20746 ? 268 LEU A N   1 
ATOM   2059 C CA  . LEU A 1 268 ? -16.56665 -5.08288  31.33783  1.000 18.57853 ? 268 LEU A CA  1 
ATOM   2060 C C   . LEU A 1 268 ? -17.09922 -3.87240  30.58891  1.000 24.47708 ? 268 LEU A C   1 
ATOM   2061 O O   . LEU A 1 268 ? -16.57246 -3.51306  29.53089  1.000 22.70427 ? 268 LEU A O   1 
ATOM   2062 C CB  . LEU A 1 268 ? -17.37328 -6.33922  30.97825  1.000 17.65462 ? 268 LEU A CB  1 
ATOM   2063 C CG  . LEU A 1 268 ? -17.61765 -6.66000  29.48339  1.000 15.26216 ? 268 LEU A CG  1 
ATOM   2064 C CD1 . LEU A 1 268 ? -16.28420 -6.81029  28.75024  1.000 17.22949 ? 268 LEU A CD1 1 
ATOM   2065 C CD2 . LEU A 1 268 ? -18.39473 -7.93839  29.39221  1.000 17.29530 ? 268 LEU A CD2 1 
ATOM   2066 N N   . LYS A 1 269 ? -18.13256 -3.22413  31.13401  1.000 20.38948 ? 269 LYS A N   1 
ATOM   2067 C CA  . LYS A 1 269 ? -18.65174 -1.99304  30.54621  1.000 24.21538 ? 269 LYS A CA  1 
ATOM   2068 C C   . LYS A 1 269 ? -17.55842 -0.93903  30.41118  1.000 23.69311 ? 269 LYS A C   1 
ATOM   2069 O O   . LYS A 1 269 ? -17.43219 -0.28801  29.36338  1.000 24.27426 ? 269 LYS A O   1 
ATOM   2070 C CB  . LYS A 1 269 ? -19.80450 -1.47219  31.40202  1.000 27.67005 ? 269 LYS A CB  1 
ATOM   2071 C CG  . LYS A 1 269 ? -20.23253 -0.05406  31.08163  1.000 26.33735 ? 269 LYS A CG  1 
ATOM   2072 C CD  . LYS A 1 269 ? -21.40571 0.36363   31.95791  1.000 33.60011 ? 269 LYS A CD  1 
ATOM   2073 C CE  . LYS A 1 269 ? -21.57408 1.88110   31.98141  1.000 38.39860 ? 269 LYS A CE  1 
ATOM   2074 N NZ  . LYS A 1 269 ? -22.61201 2.30199   32.97186  1.000 29.64871 ? 269 LYS A NZ  1 
ATOM   2075 N N   . GLU A 1 270 ? -16.75767 -0.75232  31.46820  1.000 23.61378 ? 270 GLU A N   1 
ATOM   2076 C CA  . GLU A 1 270 ? -15.68393 0.23631   31.41423  1.000 23.80592 ? 270 GLU A CA  1 
ATOM   2077 C C   . GLU A 1 270 ? -14.63173 -0.15986  30.38633  1.000 26.88994 ? 270 GLU A C   1 
ATOM   2078 O O   . GLU A 1 270 ? -14.13489 0.69185   29.63614  1.000 25.49346 ? 270 GLU A O   1 
ATOM   2079 C CB  . GLU A 1 270 ? -15.05258 0.40794   32.80070  1.000 23.92301 ? 270 GLU A CB  1 
ATOM   2080 C CG  . GLU A 1 270 ? -15.96082 1.10214   33.78836  1.000 32.24144 ? 270 GLU A CG  1 
ATOM   2081 C CD  . GLU A 1 270 ? -16.50161 2.41381   33.26258  1.000 45.46425 ? 270 GLU A CD  1 
ATOM   2082 O OE1 . GLU A 1 270 ? -15.68898 3.27429   32.86115  1.000 43.80036 ? 270 GLU A OE1 1 
ATOM   2083 O OE2 . GLU A 1 270 ? -17.74263 2.57800   33.23967  1.000 41.48479 ? 270 GLU A OE2 1 
ATOM   2084 N N   . LEU A 1 271 ? -14.31000 -1.45684  30.31914  1.000 22.80972 ? 271 LEU A N   1 
ATOM   2085 C CA  . LEU A 1 271 ? -13.37017 -1.95517  29.31606  1.000 25.39442 ? 271 LEU A CA  1 
ATOM   2086 C C   . LEU A 1 271 ? -13.88793 -1.72537  27.89713  1.000 26.98174 ? 271 LEU A C   1 
ATOM   2087 O O   . LEU A 1 271 ? -13.11494 -1.38519  26.99423  1.000 25.16242 ? 271 LEU A O   1 
ATOM   2088 C CB  . LEU A 1 271 ? -13.09828 -3.44238  29.56403  1.000 24.35829 ? 271 LEU A CB  1 
ATOM   2089 C CG  . LEU A 1 271 ? -12.24731 -3.86039  30.76950  1.000 23.60536 ? 271 LEU A CG  1 
ATOM   2090 C CD1 . LEU A 1 271 ? -12.34825 -5.35658  30.98712  1.000 24.47906 ? 271 LEU A CD1 1 
ATOM   2091 C CD2 . LEU A 1 271 ? -10.80617 -3.46162  30.52864  1.000 30.38341 ? 271 LEU A CD2 1 
ATOM   2092 N N   . LEU A 1 272 ? -15.19055 -1.91546  27.67132  1.000 21.29179 ? 272 LEU A N   1 
ATOM   2093 C CA  . LEU A 1 272 ? -15.73417 -1.68057  26.33761  1.000 21.91422 ? 272 LEU A CA  1 
ATOM   2094 C C   . LEU A 1 272 ? -15.71425 -0.19917  25.99091  1.000 29.24421 ? 272 LEU A C   1 
ATOM   2095 O O   . LEU A 1 272 ? -15.40128 0.17893   24.85763  1.000 25.30570 ? 272 LEU A O   1 
ATOM   2096 C CB  . LEU A 1 272 ? -17.15794 -2.22885  26.24175  1.000 19.15944 ? 272 LEU A CB  1 
ATOM   2097 C CG  . LEU A 1 272 ? -17.25949 -3.75385  26.22009  1.000 20.92144 ? 272 LEU A CG  1 
ATOM   2098 C CD1 . LEU A 1 272 ? -18.70856 -4.20756  26.21426  1.000 21.62437 ? 272 LEU A CD1 1 
ATOM   2099 C CD2 . LEU A 1 272 ? -16.50922 -4.31353  25.01811  1.000 22.04116 ? 272 LEU A CD2 1 
ATOM   2100 N N   . GLN A 1 273 ? -16.04191 0.65265   26.95884  1.000 26.89830 ? 273 GLN A N   1 
ATOM   2101 C CA  . GLN A 1 273 ? -16.14968 2.07682   26.68335  1.000 28.76321 ? 273 GLN A CA  1 
ATOM   2102 C C   . GLN A 1 273 ? -14.79078 2.75533   26.61152  1.000 30.45526 ? 273 GLN A C   1 
ATOM   2103 O O   . GLN A 1 273 ? -14.62923 3.73279   25.87570  1.000 32.68896 ? 273 GLN A O   1 
ATOM   2104 C CB  . GLN A 1 273 ? -17.01723 2.73544   27.74965  1.000 26.84317 ? 273 GLN A CB  1 
ATOM   2105 C CG  . GLN A 1 273 ? -18.48648 2.38152   27.61148  1.000 28.82911 ? 273 GLN A CG  1 
ATOM   2106 C CD  . GLN A 1 273 ? -19.32789 3.00095   28.69915  1.000 30.09727 ? 273 GLN A CD  1 
ATOM   2107 O OE1 . GLN A 1 273 ? -18.80312 3.49015   29.70239  1.000 34.89921 ? 273 GLN A OE1 1 
ATOM   2108 N NE2 . GLN A 1 273 ? -20.63641 2.96977   28.52144  1.000 31.21494 ? 273 GLN A NE2 1 
ATOM   2109 N N   . ASN A 1 274 ? -13.80715 2.25977   27.34685  1.000 28.37719 ? 274 ASN A N   1 
ATOM   2110 C CA  . ASN A 1 274 ? -12.52677 2.94202   27.43737  1.000 32.28213 ? 274 ASN A CA  1 
ATOM   2111 C C   . ASN A 1 274 ? -11.37551 2.14847   26.84761  1.000 36.02335 ? 274 ASN A C   1 
ATOM   2112 O O   . ASN A 1 274 ? -10.25381 2.66773   26.78878  1.000 36.75038 ? 274 ASN A O   1 
ATOM   2113 C CB  . ASN A 1 274 ? -12.22871 3.29689   28.89975  1.000 32.86695 ? 274 ASN A CB  1 
ATOM   2114 C CG  . ASN A 1 274 ? -13.31077 4.16643   29.50508  1.000 32.68709 ? 274 ASN A CG  1 
ATOM   2115 O OD1 . ASN A 1 274 ? -13.85969 3.85835   30.56000  1.000 48.02054 ? 274 ASN A OD1 1 
ATOM   2116 N ND2 . ASN A 1 274 ? -13.64424 5.25098   28.81769  1.000 38.52696 ? 274 ASN A ND2 1 
ATOM   2117 N N   . GLY A 1 275 ? -11.61710 0.92461   26.38936  1.000 38.79819 ? 275 GLY A N   1 
ATOM   2118 C CA  . GLY A 1 275 ? -10.53540 0.10973   25.89582  1.000 41.18736 ? 275 GLY A CA  1 
ATOM   2119 C C   . GLY A 1 275 ? -9.68875  -0.40758  27.04577  1.000 41.93846 ? 275 GLY A C   1 
ATOM   2120 O O   . GLY A 1 275 ? -10.03523 -0.30506  28.22319  1.000 36.24413 ? 275 GLY A O   1 
ATOM   2121 N N   . MET A 1 276 ? -8.54033  -0.96534  26.67990  1.000 38.45855 ? 276 MET A N   1 
ATOM   2122 C CA  . MET A 1 276 ? -7.65642  -1.56467  27.66532  1.000 40.14657 ? 276 MET A CA  1 
ATOM   2123 C C   . MET A 1 276 ? -6.43039  -0.71484  27.96724  1.000 45.06598 ? 276 MET A C   1 
ATOM   2124 O O   . MET A 1 276 ? -5.61088  -1.11258  28.80136  1.000 43.17799 ? 276 MET A O   1 
ATOM   2125 C CB  . MET A 1 276 ? -7.26079  -2.96812  27.20621  1.000 46.15706 ? 276 MET A CB  1 
ATOM   2126 C CG  . MET A 1 276 ? -8.49616  -3.84335  27.07651  1.000 39.11051 ? 276 MET A CG  1 
ATOM   2127 S SD  . MET A 1 276 ? -8.18028  -5.54125  26.58925  1.000 51.20348 ? 276 MET A SD  1 
ATOM   2128 C CE  . MET A 1 276 ? -6.80709  -5.88557  27.65710  1.000 15.07519 ? 276 MET A CE  1 
ATOM   2129 N N   . ASN A 1 277 ? -6.30208  0.45236   27.33429  1.000 34.57511 ? 277 ASN A N   1 
ATOM   2130 C CA  . ASN A 1 277 ? -5.30083  1.44161   27.72782  1.000 50.89123 ? 277 ASN A CA  1 
ATOM   2131 C C   . ASN A 1 277 ? -3.88992  0.87002   27.61495  1.000 55.87025 ? 277 ASN A C   1 
ATOM   2132 O O   . ASN A 1 277 ? -3.02629  1.12627   28.45942  1.000 50.61205 ? 277 ASN A O   1 
ATOM   2133 C CB  . ASN A 1 277 ? -5.57182  1.94859   29.14704  1.000 47.22527 ? 277 ASN A CB  1 
ATOM   2134 C CG  . ASN A 1 277 ? -5.36942  3.43678   29.28511  1.000 53.19240 ? 277 ASN A CG  1 
ATOM   2135 O OD1 . ASN A 1 277 ? -5.58527  4.19513   28.34046  1.000 58.80932 ? 277 ASN A OD1 1 
ATOM   2136 N ND2 . ASN A 1 277 ? -4.95279  3.86789   30.47168  1.000 57.55519 ? 277 ASN A ND2 1 
ATOM   2137 N N   . GLY A 1 278 ? -3.66324  0.06610   26.57580  1.000 35.59780 ? 278 GLY A N   1 
ATOM   2138 C CA  . GLY A 1 278 ? -2.36676  -0.54649  26.37147  1.000 40.70988 ? 278 GLY A CA  1 
ATOM   2139 C C   . GLY A 1 278 ? -1.98809  -1.59375  27.38976  1.000 38.24351 ? 278 GLY A C   1 
ATOM   2140 O O   . GLY A 1 278 ? -0.82527  -2.01132  27.42725  1.000 33.12603 ? 278 GLY A O   1 
ATOM   2141 N N   . ARG A 1 279 ? -2.92621  -2.02021  28.22920  1.000 34.54333 ? 279 ARG A N   1 
ATOM   2142 C CA  . ARG A 1 279 ? -2.68000  -3.09137  29.17454  1.000 35.46140 ? 279 ARG A CA  1 
ATOM   2143 C C   . ARG A 1 279 ? -3.10541  -4.42132  28.56351  1.000 30.28699 ? 279 ARG A C   1 
ATOM   2144 O O   . ARG A 1 279 ? -3.64266  -4.48732  27.45299  1.000 31.80931 ? 279 ARG A O   1 
ATOM   2145 C CB  . ARG A 1 279 ? -3.41266  -2.83615  30.49146  1.000 39.30471 ? 279 ARG A CB  1 
ATOM   2146 C CG  . ARG A 1 279 ? -2.61331  -2.02588  31.49542  1.000 52.09314 ? 279 ARG A CG  1 
ATOM   2147 C CD  . ARG A 1 279 ? -3.41049  -1.75697  32.75956  1.000 42.60256 ? 279 ARG A CD  1 
ATOM   2148 N NE  . ARG A 1 279 ? -4.52592  -0.85066  32.51007  1.000 53.20297 ? 279 ARG A NE  1 
ATOM   2149 C CZ  . ARG A 1 279 ? -5.16975  -0.17870  33.45552  1.000 60.74039 ? 279 ARG A CZ  1 
ATOM   2150 N NH1 . ARG A 1 279 ? -4.83506  -0.29056  34.73297  1.000 52.16397 ? 279 ARG A NH1 1 
ATOM   2151 N NH2 . ARG A 1 279 ? -6.18195  0.61569   33.11258  1.000 46.27813 ? 279 ARG A NH2 1 
ATOM   2152 N N   . THR A 1 280 ? -2.85302  -5.49741  29.29645  1.000 31.29489 ? 280 THR A N   1 
ATOM   2153 C CA  . THR A 1 280 ? -3.24206  -6.83107  28.87633  1.000 26.88863 ? 280 THR A CA  1 
ATOM   2154 C C   . THR A 1 280 ? -3.96710  -7.52955  30.01383  1.000 32.62867 ? 280 THR A C   1 
ATOM   2155 O O   . THR A 1 280 ? -3.82617  -7.16349  31.18717  1.000 27.77851 ? 280 THR A O   1 
ATOM   2156 C CB  . THR A 1 280 ? -2.02869  -7.67075  28.45247  1.000 31.82783 ? 280 THR A CB  1 
ATOM   2157 O OG1 . THR A 1 280 ? -1.17162  -7.86956  29.58366  1.000 30.17970 ? 280 THR A OG1 1 
ATOM   2158 C CG2 . THR A 1 280 ? -1.26130  -6.97570  27.34953  1.000 24.05243 ? 280 THR A CG2 1 
ATOM   2159 N N   . ILE A 1 281 ? -4.74582  -8.54775  29.64517  1.000 24.35648 ? 281 ILE A N   1 
ATOM   2160 C CA  . ILE A 1 281 ? -5.44377  -9.41802  30.58328  1.000 23.65835 ? 281 ILE A CA  1 
ATOM   2161 C C   . ILE A 1 281 ? -5.15636  -10.85814 30.18321  1.000 21.56870 ? 281 ILE A C   1 
ATOM   2162 O O   . ILE A 1 281 ? -5.48566  -11.26857 29.05863  1.000 20.82134 ? 281 ILE A O   1 
ATOM   2163 C CB  . ILE A 1 281 ? -6.96290  -9.17255  30.59923  1.000 19.57304 ? 281 ILE A CB  1 
ATOM   2164 C CG1 . ILE A 1 281 ? -7.28362  -7.73335  30.98780  1.000 24.98257 ? 281 ILE A CG1 1 
ATOM   2165 C CG2 . ILE A 1 281 ? -7.63092  -10.15891 31.53515  1.000 20.68606 ? 281 ILE A CG2 1 
ATOM   2166 C CD1 . ILE A 1 281 ? -8.75922  -7.41211  30.93831  1.000 23.81676 ? 281 ILE A CD1 1 
ATOM   2167 N N   . LEU A 1 282 ? -4.54682  -11.62145 31.09848  1.000 23.26951 ? 282 LEU A N   1 
ATOM   2168 C CA  . LEU A 1 282 ? -4.15459  -13.00395 30.83294  1.000 23.17797 ? 282 LEU A CA  1 
ATOM   2169 C C   . LEU A 1 282 ? -3.38105  -13.10170 29.52100  1.000 24.23538 ? 282 LEU A C   1 
ATOM   2170 O O   . LEU A 1 282 ? -3.59342  -14.00857 28.71078  1.000 23.77237 ? 282 LEU A O   1 
ATOM   2171 C CB  . LEU A 1 282 ? -5.36812  -13.93846 30.83478  1.000 25.53904 ? 282 LEU A CB  1 
ATOM   2172 C CG  . LEU A 1 282 ? -5.96054  -14.20122 32.22146  1.000 23.60248 ? 282 LEU A CG  1 
ATOM   2173 C CD1 . LEU A 1 282 ? -7.17612  -15.11651 32.14564  1.000 26.20369 ? 282 LEU A CD1 1 
ATOM   2174 C CD2 . LEU A 1 282 ? -4.89661  -14.78248 33.15202  1.000 23.44451 ? 282 LEU A CD2 1 
ATOM   2175 N N   . GLY A 1 283 ? -2.49040  -12.13304 29.30998  1.000 25.57516 ? 283 GLY A N   1 
ATOM   2176 C CA  . GLY A 1 283 ? -1.62609  -12.10479 28.15164  1.000 29.54720 ? 283 GLY A CA  1 
ATOM   2177 C C   . GLY A 1 283 ? -2.27731  -11.67973 26.85633  1.000 34.55253 ? 283 GLY A C   1 
ATOM   2178 O O   . GLY A 1 283 ? -1.64585  -11.80179 25.80125  1.000 32.47242 ? 283 GLY A O   1 
ATOM   2179 N N   . SER A 1 284 ? -3.51533  -11.19360 26.89221  1.000 23.13087 ? 284 SER A N   1 
ATOM   2180 C CA  A SER A 1 284 ? -4.22570  -10.79081 25.68667  0.600 22.76989 ? 284 SER A CA  1 
ATOM   2181 C CA  B SER A 1 284 ? -4.25034  -10.79534 25.69716  0.400 22.77999 ? 284 SER A CA  1 
ATOM   2182 C C   . SER A 1 284 ? -4.47045  -9.28944  25.70484  1.000 26.15963 ? 284 SER A C   1 
ATOM   2183 O O   . SER A 1 284 ? -4.73235  -8.70255  26.75532  1.000 23.76651 ? 284 SER A O   1 
ATOM   2184 C CB  A SER A 1 284 ? -5.56399  -11.52628 25.54065  0.600 21.02033 ? 284 SER A CB  1 
ATOM   2185 C CB  B SER A 1 284 ? -5.61734  -11.50186 25.60965  0.400 20.95383 ? 284 SER A CB  1 
ATOM   2186 O OG  A SER A 1 284 ? -6.24484  -11.08512 24.37703  0.600 16.74354 ? 284 SER A OG  1 
ATOM   2187 O OG  B SER A 1 284 ? -5.49056  -12.89480 25.39011  0.400 23.97333 ? 284 SER A OG  1 
ATOM   2188 N N   . ALA A 1 285 ? -4.38564  -8.66749  24.53012  1.000 24.48964 ? 285 ALA A N   1 
ATOM   2189 C CA  . ALA A 1 285 ? -4.70277  -7.25391  24.40996  1.000 24.20840 ? 285 ALA A CA  1 
ATOM   2190 C C   . ALA A 1 285 ? -6.11859  -7.03457  23.89793  1.000 23.93627 ? 285 ALA A C   1 
ATOM   2191 O O   . ALA A 1 285 ? -6.48190  -5.90355  23.55296  1.000 26.32915 ? 285 ALA A O   1 
ATOM   2192 C CB  . ALA A 1 285 ? -3.69603  -6.54402  23.50670  1.000 23.69380 ? 285 ALA A CB  1 
ATOM   2193 N N   . LEU A 1 286 ? -6.92144  -8.09061  23.83606  1.000 20.79831 ? 286 LEU A N   1 
ATOM   2194 C CA  A LEU A 1 286 ? -8.33333  -7.92899  23.54403  0.500 23.39031 ? 286 LEU A CA  1 
ATOM   2195 C CA  B LEU A 1 286 ? -8.32611  -8.03844  23.45879  0.500 23.48846 ? 286 LEU A CA  1 
ATOM   2196 C C   . LEU A 1 286 ? -9.15172  -8.80153  24.48497  1.000 19.06370 ? 286 LEU A C   1 
ATOM   2197 O O   . LEU A 1 286 ? -8.62799  -9.63099  25.23991  1.000 21.81002 ? 286 LEU A O   1 
ATOM   2198 C CB  A LEU A 1 286 ? -8.64812  -8.23973  22.07351  0.500 24.27211 ? 286 LEU A CB  1 
ATOM   2199 C CB  B LEU A 1 286 ? -8.57662  -8.66165  22.07714  0.500 25.18335 ? 286 LEU A CB  1 
ATOM   2200 C CG  A LEU A 1 286 ? -8.01309  -9.46959  21.42240  0.500 19.51944 ? 286 LEU A CG  1 
ATOM   2201 C CG  B LEU A 1 286 ? -7.87023  -8.11246  20.84285  0.500 29.98069 ? 286 LEU A CG  1 
ATOM   2202 C CD1 A LEU A 1 286 ? -8.73972  -10.74100 21.82145  0.500 24.49042 ? 286 LEU A CD1 1 
ATOM   2203 C CD1 B LEU A 1 286 ? -7.96063  -9.10353  19.69083  0.500 28.46215 ? 286 LEU A CD1 1 
ATOM   2204 C CD2 A LEU A 1 286 ? -8.00428  -9.31172  19.90717  0.500 27.89657 ? 286 LEU A CD2 1 
ATOM   2205 C CD2 B LEU A 1 286 ? -8.47372  -6.78232  20.45393  0.500 22.45300 ? 286 LEU A CD2 1 
ATOM   2206 N N   . LEU A 1 287 ? -10.45536 -8.56390  24.46746  1.000 18.28185 ? 287 LEU A N   1 
ATOM   2207 C CA  . LEU A 1 287 ? -11.37130 -9.31183  25.31236  1.000 21.10167 ? 287 LEU A CA  1 
ATOM   2208 C C   . LEU A 1 287 ? -11.63796 -10.66860 24.66588  1.000 14.46079 ? 287 LEU A C   1 
ATOM   2209 O O   . LEU A 1 287 ? -12.13077 -10.74014 23.53676  1.000 21.30783 ? 287 LEU A O   1 
ATOM   2210 C CB  . LEU A 1 287 ? -12.64986 -8.50369  25.51130  1.000 19.33929 ? 287 LEU A CB  1 
ATOM   2211 C CG  . LEU A 1 287 ? -12.27989 -7.15681  26.15597  1.000 21.00261 ? 287 LEU A CG  1 
ATOM   2212 C CD1 . LEU A 1 287 ? -13.43182 -6.16319  26.12684  1.000 22.82392 ? 287 LEU A CD1 1 
ATOM   2213 C CD2 . LEU A 1 287 ? -11.76648 -7.38844  27.59827  1.000 24.38988 ? 287 LEU A CD2 1 
ATOM   2214 N N   . GLU A 1 288 ? -11.30168 -11.73617 25.38464  1.000 17.20021 ? 288 GLU A N   1 
ATOM   2215 C CA  A GLU A 1 288 ? -11.35303 -13.10013 24.87439  0.500 19.12288 ? 288 GLU A CA  1 
ATOM   2216 C CA  B GLU A 1 288 ? -11.35535 -13.09554 24.86402  0.500 19.11049 ? 288 GLU A CA  1 
ATOM   2217 C C   . GLU A 1 288 ? -12.71735 -13.72503 25.13591  1.000 18.05171 ? 288 GLU A C   1 
ATOM   2218 O O   . GLU A 1 288 ? -13.21754 -13.68390 26.26256  1.000 18.76359 ? 288 GLU A O   1 
ATOM   2219 C CB  A GLU A 1 288 ? -10.26481 -13.94796 25.53929  0.500 17.92201 ? 288 GLU A CB  1 
ATOM   2220 C CB  B GLU A 1 288 ? -10.25131 -13.94843 25.49755  0.500 17.96201 ? 288 GLU A CB  1 
ATOM   2221 C CG  A GLU A 1 288 ? -10.33660 -15.43179 25.20212  0.500 17.74861 ? 288 GLU A CG  1 
ATOM   2222 C CG  B GLU A 1 288 ? -8.83025  -13.44882 25.24614  0.500 18.12513 ? 288 GLU A CG  1 
ATOM   2223 C CD  A GLU A 1 288 ? -10.02919 -15.69491 23.75071  0.500 25.30789 ? 288 GLU A CD  1 
ATOM   2224 C CD  B GLU A 1 288 ? -8.22209  -14.00054 23.97608  0.500 28.96109 ? 288 GLU A CD  1 
ATOM   2225 O OE1 A GLU A 1 288 ? -8.96666  -15.23215 23.28827  0.500 26.67440 ? 288 GLU A OE1 1 
ATOM   2226 O OE1 B GLU A 1 288 ? -8.72196  -15.03734 23.48467  0.500 24.83653 ? 288 GLU A OE1 1 
ATOM   2227 O OE2 A GLU A 1 288 ? -10.85493 -16.33435 23.06788  0.500 16.21218 ? 288 GLU A OE2 1 
ATOM   2228 O OE2 B GLU A 1 288 ? -7.24162  -13.39730 23.47767  0.500 22.88263 ? 288 GLU A OE2 1 
ATOM   2229 N N   . ASP A 1 289 ? -13.30311 -14.34738 24.10619  1.000 15.95805 ? 289 ASP A N   1 
ATOM   2230 C CA  . ASP A 1 289 ? -14.63905 -14.91307 24.26908  1.000 22.66941 ? 289 ASP A CA  1 
ATOM   2231 C C   . ASP A 1 289 ? -14.73035 -16.38707 23.87384  1.000 17.35868 ? 289 ASP A C   1 
ATOM   2232 O O   . ASP A 1 289 ? -15.83841 -16.90623 23.71925  1.000 17.75993 ? 289 ASP A O   1 
ATOM   2233 C CB  . ASP A 1 289 ? -15.68075 -14.06811 23.51405  1.000 19.05018 ? 289 ASP A CB  1 
ATOM   2234 C CG  . ASP A 1 289 ? -15.77460 -14.37638 22.01131  1.000 21.00804 ? 289 ASP A CG  1 
ATOM   2235 O OD1 . ASP A 1 289 ? -14.84136 -14.94340 21.40318  1.000 16.07914 ? 289 ASP A OD1 1 
ATOM   2236 O OD2 . ASP A 1 289 ? -16.80076 -13.96472 21.42909  1.000 16.91908 ? 289 ASP A OD2 1 
ATOM   2237 N N   . GLU A 1 290 ? -13.60396 -17.09691 23.77651  1.000 18.58003 ? 290 GLU A N   1 
ATOM   2238 C CA  . GLU A 1 290 ? -13.63930 -18.53078 23.51163  1.000 19.71023 ? 290 GLU A CA  1 
ATOM   2239 C C   . GLU A 1 290 ? -13.42034 -19.41064 24.74333  1.000 25.06790 ? 290 GLU A C   1 
ATOM   2240 O O   . GLU A 1 290 ? -13.03548 -20.57420 24.58625  1.000 22.48938 ? 290 GLU A O   1 
ATOM   2241 C CB  . GLU A 1 290 ? -12.60107 -18.90621 22.46744  1.000 29.34341 ? 290 GLU A CB  1 
ATOM   2242 C CG  . GLU A 1 290 ? -12.76516 -18.29901 21.15566  1.000 30.67795 ? 290 GLU A CG  1 
ATOM   2243 C CD  . GLU A 1 290 ? -11.99432 -19.10706 20.14437  1.000 36.30497 ? 290 GLU A CD  1 
ATOM   2244 O OE1 . GLU A 1 290 ? -10.76809 -19.32354 20.33164  1.000 31.95801 ? 290 GLU A OE1 1 
ATOM   2245 O OE2 . GLU A 1 290 ? -12.64488 -19.57765 19.20272  1.000 20.37856 ? 290 GLU A OE2 1 
ATOM   2246 N N   . PHE A 1 291 ? -13.67268 -18.91645 25.95636  1.000 16.62246 ? 291 PHE A N   1 
ATOM   2247 C CA  . PHE A 1 291 ? -13.74114 -19.78641 27.12486  1.000 15.77522 ? 291 PHE A CA  1 
ATOM   2248 C C   . PHE A 1 291 ? -15.13311 -19.71000 27.71489  1.000 14.87421 ? 291 PHE A C   1 
ATOM   2249 O O   . PHE A 1 291 ? -15.56583 -18.62587 28.12423  1.000 16.70359 ? 291 PHE A O   1 
ATOM   2250 C CB  . PHE A 1 291 ? -12.74482 -19.38831 28.21881  1.000 20.13124 ? 291 PHE A CB  1 
ATOM   2251 C CG  . PHE A 1 291 ? -11.31920 -19.46609 27.81076  1.000 22.47054 ? 291 PHE A CG  1 
ATOM   2252 C CD1 . PHE A 1 291 ? -10.60001 -20.63702 27.99427  1.000 23.57002 ? 291 PHE A CD1 1 
ATOM   2253 C CD2 . PHE A 1 291 ? -10.67698 -18.35713 27.30203  1.000 18.08023 ? 291 PHE A CD2 1 
ATOM   2254 C CE1 . PHE A 1 291 ? -9.26360  -20.70125 27.63617  1.000 29.99944 ? 291 PHE A CE1 1 
ATOM   2255 C CE2 . PHE A 1 291 ? -9.33682  -18.41219 26.94228  1.000 26.84845 ? 291 PHE A CE2 1 
ATOM   2256 C CZ  . PHE A 1 291 ? -8.63324  -19.59016 27.11352  1.000 25.53735 ? 291 PHE A CZ  1 
ATOM   2257 N N   . THR A 1 292 ? -15.78570 -20.84644 27.83827  1.000 15.70037 ? 292 THR A N   1 
ATOM   2258 C CA  . THR A 1 292 ? -17.07249 -20.88955 28.51013  1.000 15.65846 ? 292 THR A CA  1 
ATOM   2259 C C   . THR A 1 292 ? -16.86987 -20.87595 30.02717  1.000 18.42601 ? 292 THR A C   1 
ATOM   2260 O O   . THR A 1 292 ? -15.76473 -21.12567 30.51711  1.000 19.52158 ? 292 THR A O   1 
ATOM   2261 C CB  . THR A 1 292 ? -17.84830 -22.13440 28.11420  1.000 20.94863 ? 292 THR A CB  1 
ATOM   2262 O OG1 . THR A 1 292 ? -17.20819 -23.29529 28.65126  1.000 20.54768 ? 292 THR A OG1 1 
ATOM   2263 C CG2 . THR A 1 292 ? -17.92743 -22.27511 26.60291  1.000 19.51309 ? 292 THR A CG2 1 
ATOM   2264 N N   . PRO A 1 293 ? -17.92581 -20.59660 30.79452  1.000 21.73018 ? 293 PRO A N   1 
ATOM   2265 C CA  . PRO A 1 293 ? -17.80575 -20.74169 32.25393  1.000 17.94823 ? 293 PRO A CA  1 
ATOM   2266 C C   . PRO A 1 293 ? -17.37060 -22.13914 32.66075  1.000 19.53301 ? 293 PRO A C   1 
ATOM   2267 O O   . PRO A 1 293 ? -16.55797 -22.28384 33.57662  1.000 21.61665 ? 293 PRO A O   1 
ATOM   2268 C CB  . PRO A 1 293 ? -19.21826 -20.40044 32.75021  1.000 22.94611 ? 293 PRO A CB  1 
ATOM   2269 C CG  . PRO A 1 293 ? -19.72730 -19.44988 31.71184  1.000 20.10972 ? 293 PRO A CG  1 
ATOM   2270 C CD  . PRO A 1 293 ? -19.18433 -19.92905 30.39927  1.000 20.55017 ? 293 PRO A CD  1 
ATOM   2271 N N   . PHE A 1 294 ? -17.84479 -23.17568 31.95579  1.000 17.10324 ? 294 PHE A N   1 
ATOM   2272 C CA  . PHE A 1 294 ? -17.42776 -24.53537 32.29291  1.000 23.92530 ? 294 PHE A CA  1 
ATOM   2273 C C   . PHE A 1 294 ? -15.94550 -24.74076 32.00156  1.000 28.19678 ? 294 PHE A C   1 
ATOM   2274 O O   . PHE A 1 294 ? -15.23994 -25.38434 32.79401  1.000 24.63162 ? 294 PHE A O   1 
ATOM   2275 C CB  . PHE A 1 294 ? -18.28233 -25.55957 31.54494  1.000 28.34716 ? 294 PHE A CB  1 
ATOM   2276 N N   . ASP A 1 295 ? -15.45103 -24.17311 30.89063  1.000 19.30924 ? 295 ASP A N   1 
ATOM   2277 C CA  . ASP A 1 295 ? -14.02694 -24.22870 30.56941  1.000 21.24773 ? 295 ASP A CA  1 
ATOM   2278 C C   . ASP A 1 295 ? -13.18202 -23.64001 31.69042  1.000 31.26961 ? 295 ASP A C   1 
ATOM   2279 O O   . ASP A 1 295 ? -12.12594 -24.18254 32.03596  1.000 26.93239 ? 295 ASP A O   1 
ATOM   2280 C CB  . ASP A 1 295 ? -13.73238 -23.48506 29.26507  1.000 22.62776 ? 295 ASP A CB  1 
ATOM   2281 C CG  . ASP A 1 295 ? -14.33528 -24.16294 28.05139  1.000 24.04946 ? 295 ASP A CG  1 
ATOM   2282 O OD1 . ASP A 1 295 ? -14.66765 -25.36429 28.13221  1.000 30.19550 ? 295 ASP A OD1 1 
ATOM   2283 O OD2 . ASP A 1 295 ? -14.46716 -23.47894 27.01547  1.000 22.45008 ? 295 ASP A OD2 1 
ATOM   2284 N N   . VAL A 1 296 ? -13.60054 -22.49167 32.22699  1.000 21.43342 ? 296 VAL A N   1 
ATOM   2285 C CA  . VAL A 1 296 ? -12.81636 -21.82099 33.25497  1.000 22.67112 ? 296 VAL A CA  1 
ATOM   2286 C C   . VAL A 1 296 ? -12.77553 -22.65860 34.52500  1.000 29.16011 ? 296 VAL A C   1 
ATOM   2287 O O   . VAL A 1 296 ? -11.71517 -22.83560 35.13143  1.000 28.82265 ? 296 VAL A O   1 
ATOM   2288 C CB  . VAL A 1 296 ? -13.37669 -20.41329 33.52072  1.000 23.61259 ? 296 VAL A CB  1 
ATOM   2289 C CG1 . VAL A 1 296 ? -12.72115 -19.82039 34.77390  1.000 23.29271 ? 296 VAL A CG1 1 
ATOM   2290 C CG2 . VAL A 1 296 ? -13.12509 -19.53749 32.32067  1.000 19.14892 ? 296 VAL A CG2 1 
ATOM   2291 N N   . VAL A 1 297 ? -13.92275 -23.19086 34.94024  1.000 24.50188 ? 297 VAL A N   1 
ATOM   2292 C CA  . VAL A 1 297 ? -13.96243 -24.03360 36.13257  1.000 25.79536 ? 297 VAL A CA  1 
ATOM   2293 C C   . VAL A 1 297 ? -13.12004 -25.28859 35.92997  1.000 30.88608 ? 297 VAL A C   1 
ATOM   2294 O O   . VAL A 1 297 ? -12.34780 -25.68128 36.81353  1.000 35.82347 ? 297 VAL A O   1 
ATOM   2295 C CB  . VAL A 1 297 ? -15.41826 -24.38278 36.48817  1.000 25.33026 ? 297 VAL A CB  1 
ATOM   2296 C CG1 . VAL A 1 297 ? -15.47164 -25.43868 37.58418  1.000 29.23925 ? 297 VAL A CG1 1 
ATOM   2297 C CG2 . VAL A 1 297 ? -16.18626 -23.13719 36.88777  1.000 25.12092 ? 297 VAL A CG2 1 
ATOM   2298 N N   . ARG A 1 298 ? -13.26826 -25.94218 34.77080  1.000 30.91099 ? 298 ARG A N   1 
ATOM   2299 C CA  . ARG A 1 298 ? -12.46125 -27.11288 34.43188  1.000 31.53348 ? 298 ARG A CA  1 
ATOM   2300 C C   . ARG A 1 298 ? -10.98335 -26.82737 34.63366  1.000 28.63340 ? 298 ARG A C   1 
ATOM   2301 O O   . ARG A 1 298 ? -10.28730 -27.52969 35.37801  1.000 42.78422 ? 298 ARG A O   1 
ATOM   2302 C CB  . ARG A 1 298 ? -12.70267 -27.52958 32.97155  1.000 30.30454 ? 298 ARG A CB  1 
ATOM   2303 C CG  . ARG A 1 298 ? -13.90147 -28.42638 32.72666  1.000 55.09115 ? 298 ARG A CG  1 
ATOM   2304 C CD  . ARG A 1 298 ? -13.74210 -29.26156 31.44445  1.000 63.62470 ? 298 ARG A CD  1 
ATOM   2305 N NE  . ARG A 1 298 ? -13.82182 -28.48456 30.20917  1.000 37.58070 ? 298 ARG A NE  1 
ATOM   2306 C CZ  . ARG A 1 298 ? -12.77646 -28.16360 29.45630  1.000 53.89579 ? 298 ARG A CZ  1 
ATOM   2307 N NH1 . ARG A 1 298 ? -11.54307 -28.50242 29.80745  1.000 46.08212 ? 298 ARG A NH1 1 
ATOM   2308 N NH2 . ARG A 1 298 ? -12.97442 -27.49723 28.31595  1.000 32.75174 ? 298 ARG A NH2 1 
ATOM   2309 N N   . GLN A 1 299 ? -10.49111 -25.78818 33.96633  1.000 32.16032 ? 299 GLN A N   1 
ATOM   2310 C CA  . GLN A 1 299 ? -9.06520  -25.51339 33.98538  1.000 42.47166 ? 299 GLN A CA  1 
ATOM   2311 C C   . GLN A 1 299 ? -8.61027  -25.08970 35.36960  1.000 46.02389 ? 299 GLN A C   1 
ATOM   2312 O O   . GLN A 1 299 ? -7.50772  -25.44362 35.79730  1.000 50.91263 ? 299 GLN A O   1 
ATOM   2313 C CB  . GLN A 1 299 ? -8.71730  -24.44717 32.94849  1.000 44.43036 ? 299 GLN A CB  1 
ATOM   2314 C CG  . GLN A 1 299 ? -7.22953  -24.17393 32.85594  1.000 29.21058 ? 299 GLN A CG  1 
ATOM   2315 C CD  . GLN A 1 299 ? -6.81861  -23.50240 31.56953  1.000 30.76194 ? 299 GLN A CD  1 
ATOM   2316 O OE1 . GLN A 1 299 ? -5.71380  -22.98243 31.46953  1.000 27.39619 ? 299 GLN A OE1 1 
ATOM   2317 N NE2 . GLN A 1 299 ? -7.70181  -23.51378 30.56863  1.000 22.99116 ? 299 GLN A NE2 1 
ATOM   2318 N N   . CYS A 1 300 ? -9.44917  -24.35115 36.09422  1.000 38.79455 ? 300 CYS A N   1 
ATOM   2319 C CA  . CYS A 1 300 ? -9.04949  -23.88504 37.41503  1.000 44.02004 ? 300 CYS A CA  1 
ATOM   2320 C C   . CYS A 1 300 ? -9.18144  -24.96315 38.49099  1.000 49.94582 ? 300 CYS A C   1 
ATOM   2321 O O   . CYS A 1 300 ? -8.57579  -24.82583 39.55964  1.000 38.99734 ? 300 CYS A O   1 
ATOM   2322 C CB  . CYS A 1 300 ? -9.85643  -22.63888 37.78962  1.000 33.52020 ? 300 CYS A CB  1 
ATOM   2323 S SG  . CYS A 1 300 ? -9.50296  -21.19254 36.74030  1.000 40.59517 ? 300 CYS A SG  1 
ATOM   2324 N N   . SER A 1 301 ? -9.91997  -26.04455 38.22602  1.000 48.03231 ? 301 SER A N   1 
ATOM   2325 C CA  . SER A 1 301 ? -10.09989 -27.12726 39.18640  1.000 40.39901 ? 301 SER A CA  1 
ATOM   2326 C C   . SER A 1 301 ? -9.39551  -28.41958 38.78293  1.000 58.78598 ? 301 SER A C   1 
ATOM   2327 O O   . SER A 1 301 ? -9.45687  -29.40354 39.53099  1.000 44.20658 ? 301 SER A O   1 
ATOM   2328 C CB  . SER A 1 301 ? -11.59533 -27.40472 39.40171  1.000 37.20349 ? 301 SER A CB  1 
ATOM   2329 O OG  . SER A 1 301 ? -12.16057 -28.09003 38.29430  1.000 42.03099 ? 301 SER A OG  1 
ATOM   2330 N N   . GLY A 1 302 ? -8.73600  -28.45101 37.62803  1.000 63.77582 ? 302 GLY A N   1 
ATOM   2331 C CA  . GLY A 1 302 ? -7.99399  -29.62602 37.20048  1.000 43.18415 ? 302 GLY A CA  1 
ATOM   2332 C C   . GLY A 1 302 ? -8.87255  -30.78968 36.78553  1.000 48.86148 ? 302 GLY A C   1 
ATOM   2333 O O   . GLY A 1 302 ? -8.57079  -31.93817 37.10784  1.000 54.05944 ? 302 GLY A O   1 
HETATM 2334 O O   . HOH B 2 .   ? -7.16543  -36.16211 -7.95973  1.000 47.85125 ? 401 HOH A O   1 
HETATM 2335 O O   . HOH B 2 .   ? -30.04577 -33.93859 -0.32508  1.000 31.93168 ? 402 HOH A O   1 
HETATM 2336 O O   . HOH B 2 .   ? -8.47298  -27.58200 11.88127  1.000 40.58946 ? 403 HOH A O   1 
HETATM 2337 O O   . HOH B 2 .   ? -10.78985 -22.15521 0.58073   1.000 37.03233 ? 404 HOH A O   1 
HETATM 2338 O O   . HOH B 2 .   ? -22.13871 -32.95841 -11.05458 1.000 37.95272 ? 405 HOH A O   1 
HETATM 2339 O O   . HOH B 2 .   ? -28.98825 -32.67866 14.01031  1.000 40.62958 ? 406 HOH A O   1 
HETATM 2340 O O   . HOH B 2 .   ? -11.79158 -50.11009 1.53985   1.000 29.68153 ? 407 HOH A O   1 
HETATM 2341 O O   . HOH B 2 .   ? -18.25740 -15.43098 6.36174   1.000 37.51738 ? 408 HOH A O   1 
HETATM 2342 O O   . HOH B 2 .   ? -33.15808 -6.39588  34.21145  1.000 41.23526 ? 409 HOH A O   1 
HETATM 2343 O O   . HOH B 2 .   ? -25.08655 -17.38108 10.16252  1.000 20.59567 ? 410 HOH A O   1 
HETATM 2344 O O   . HOH B 2 .   ? -7.24826  -46.95107 0.11975   1.000 36.45712 ? 411 HOH A O   1 
HETATM 2345 O O   . HOH B 2 .   ? -20.24647 -25.38707 28.51192  1.000 49.17652 ? 412 HOH A O   1 
HETATM 2346 O O   . HOH B 2 .   ? -8.19968  -15.08454 20.97739  1.000 42.84782 ? 413 HOH A O   1 
HETATM 2347 O O   . HOH B 2 .   ? -19.00056 -16.21762 3.05860   1.000 40.86143 ? 414 HOH A O   1 
HETATM 2348 O O   . HOH B 2 .   ? -13.89377 -17.84822 18.00142  1.000 22.47143 ? 415 HOH A O   1 
HETATM 2349 O O   . HOH B 2 .   ? -6.52404  4.52255   26.09931  1.000 48.81410 ? 416 HOH A O   1 
HETATM 2350 O O   . HOH B 2 .   ? -19.05660 -5.49482  15.61802  1.000 43.51625 ? 417 HOH A O   1 
HETATM 2351 O O   . HOH B 2 .   ? -9.08704  -19.05222 11.69331  1.000 29.89509 ? 418 HOH A O   1 
HETATM 2352 O O   . HOH B 2 .   ? -16.25014 4.57623   30.82688  1.000 36.37640 ? 419 HOH A O   1 
HETATM 2353 O O   . HOH B 2 .   ? -31.44302 -32.72169 5.20305   1.000 38.46397 ? 420 HOH A O   1 
HETATM 2354 O O   . HOH B 2 .   ? -5.13504  -0.75979  24.75091  1.000 46.21129 ? 421 HOH A O   1 
HETATM 2355 O O   . HOH B 2 .   ? -17.26157 -53.59212 -0.70879  1.000 34.28688 ? 422 HOH A O   1 
HETATM 2356 O O   . HOH B 2 .   ? -26.71220 -27.78175 -5.65959  1.000 38.84198 ? 423 HOH A O   1 
HETATM 2357 O O   . HOH B 2 .   ? -28.05615 -34.82454 -11.84170 1.000 36.95435 ? 424 HOH A O   1 
HETATM 2358 O O   . HOH B 2 .   ? -7.90366  -4.07379  22.61236  1.000 40.50041 ? 425 HOH A O   1 
HETATM 2359 O O   . HOH B 2 .   ? -7.73569  -21.94591 1.91332   1.000 35.76235 ? 426 HOH A O   1 
HETATM 2360 O O   . HOH B 2 .   ? -19.10582 -21.50008 0.06599   1.000 36.61082 ? 427 HOH A O   1 
HETATM 2361 O O   . HOH B 2 .   ? -2.56654  -9.71795  41.62690  1.000 28.97990 ? 428 HOH A O   1 
HETATM 2362 O O   . HOH B 2 .   ? -17.21553 -4.33987  19.90329  1.000 24.96195 ? 429 HOH A O   1 
HETATM 2363 O O   . HOH B 2 .   ? -14.25428 -44.98309 -6.38902  1.000 45.87724 ? 430 HOH A O   1 
HETATM 2364 O O   . HOH B 2 .   ? -19.18903 -36.37961 26.61104  1.000 33.46270 ? 431 HOH A O   1 
HETATM 2365 O O   . HOH B 2 .   ? -7.20076  -13.26247 42.93220  1.000 37.40179 ? 432 HOH A O   1 
HETATM 2366 O O   . HOH B 2 .   ? -12.74533 -9.83087  21.22219  1.000 35.91089 ? 433 HOH A O   1 
HETATM 2367 O O   . HOH B 2 .   ? -17.99769 -51.43377 18.55810  1.000 30.07974 ? 434 HOH A O   1 
HETATM 2368 O O   . HOH B 2 .   ? -20.81970 -35.88771 -12.63887 1.000 45.02259 ? 435 HOH A O   1 
HETATM 2369 O O   . HOH B 2 .   ? -23.85699 -21.25636 24.33949  1.000 29.84985 ? 436 HOH A O   1 
HETATM 2370 O O   . HOH B 2 .   ? -30.86701 0.14825   34.43764  1.000 40.07862 ? 437 HOH A O   1 
HETATM 2371 O O   . HOH B 2 .   ? -7.302    -22.405   19.501    1.000 29.79421 ? 438 HOH A O   1 
HETATM 2372 O O   . HOH B 2 .   ? -12.72785 -1.95386  34.04809  1.000 33.21621 ? 439 HOH A O   1 
HETATM 2373 O O   . HOH B 2 .   ? -8.93969  -44.42953 1.26794   1.000 34.69522 ? 440 HOH A O   1 
HETATM 2374 O O   . HOH B 2 .   ? -9.71335  -44.36106 20.04648  1.000 25.26659 ? 441 HOH A O   1 
HETATM 2375 O O   . HOH B 2 .   ? -31.94584 -34.63534 -5.50374  1.000 35.65154 ? 442 HOH A O   1 
HETATM 2376 O O   . HOH B 2 .   ? -14.31885 -20.08475 16.31412  1.000 18.04433 ? 443 HOH A O   1 
HETATM 2377 O O   . HOH B 2 .   ? -15.35356 -38.38021 -5.86382  1.000 40.36083 ? 444 HOH A O   1 
HETATM 2378 O O   . HOH B 2 .   ? -20.46860 -54.53713 10.49483  1.000 39.52180 ? 445 HOH A O   1 
HETATM 2379 O O   . HOH B 2 .   ? -1.73935  -9.91188  31.11503  1.000 36.70652 ? 446 HOH A O   1 
HETATM 2380 O O   . HOH B 2 .   ? -28.28551 -20.91979 33.33530  1.000 29.93774 ? 447 HOH A O   1 
HETATM 2381 O O   . HOH B 2 .   ? -11.70239 -14.51790 21.38297  1.000 32.09129 ? 448 HOH A O   1 
HETATM 2382 O O   . HOH B 2 .   ? -14.41419 -6.62913  22.65113  1.000 25.33604 ? 449 HOH A O   1 
HETATM 2383 O O   . HOH B 2 .   ? -21.54530 -40.01288 -9.28594  1.000 33.34117 ? 450 HOH A O   1 
HETATM 2384 O O   . HOH B 2 .   ? -25.53626 -5.00936  18.64487  1.000 36.68847 ? 451 HOH A O   1 
HETATM 2385 O O   . HOH B 2 .   ? -4.64227  -27.70813 9.85856   1.000 31.03511 ? 452 HOH A O   1 
HETATM 2386 O O   . HOH B 2 .   ? -27.27387 -3.32874  40.04829  1.000 30.58302 ? 453 HOH A O   1 
HETATM 2387 O O   . HOH B 2 .   ? -0.94134  2.12906   29.70708  1.000 39.08337 ? 454 HOH A O   1 
HETATM 2388 O O   . HOH B 2 .   ? -17.09343 -3.14088  41.14920  1.000 41.67333 ? 455 HOH A O   1 
HETATM 2389 O O   . HOH B 2 .   ? -17.07890 -13.94359 13.17560  1.000 33.83496 ? 456 HOH A O   1 
HETATM 2390 O O   . HOH B 2 .   ? -14.67731 -27.31575 25.40947  1.000 23.75844 ? 457 HOH A O   1 
HETATM 2391 O O   . HOH B 2 .   ? -30.67367 -20.32277 34.46863  1.000 29.86301 ? 458 HOH A O   1 
HETATM 2392 O O   . HOH B 2 .   ? -10.66215 -35.20793 13.46971  1.000 17.56391 ? 459 HOH A O   1 
HETATM 2393 O O   . HOH B 2 .   ? -28.83301 -13.08458 24.58066  1.000 28.79229 ? 460 HOH A O   1 
HETATM 2394 O O   . HOH B 2 .   ? -25.22171 -40.00659 11.79113  1.000 22.36948 ? 461 HOH A O   1 
HETATM 2395 O O   . HOH B 2 .   ? -14.01607 -21.01353 -0.30848  1.000 35.16354 ? 462 HOH A O   1 
HETATM 2396 O O   . HOH B 2 .   ? -19.12524 -7.92363  44.32748  1.000 26.42109 ? 463 HOH A O   1 
HETATM 2397 O O   . HOH B 2 .   ? -28.01230 -24.97982 6.65071   1.000 19.30535 ? 464 HOH A O   1 
HETATM 2398 O O   . HOH B 2 .   ? -3.31549  -22.67171 23.35636  1.000 40.49324 ? 465 HOH A O   1 
HETATM 2399 O O   . HOH B 2 .   ? -17.287   -22.006   42.885    1.000 36.48750 ? 466 HOH A O   1 
HETATM 2400 O O   . HOH B 2 .   ? 0.79892   -1.45847  29.46091  1.000 43.57268 ? 467 HOH A O   1 
HETATM 2401 O O   . HOH B 2 .   ? -12.57009 2.06613   40.54008  1.000 40.86726 ? 468 HOH A O   1 
HETATM 2402 O O   . HOH B 2 .   ? -10.58158 -28.31429 26.48443  1.000 22.14813 ? 469 HOH A O   1 
HETATM 2403 O O   . HOH B 2 .   ? -18.51980 -8.14412  18.59668  1.000 29.87921 ? 470 HOH A O   1 
HETATM 2404 O O   . HOH B 2 .   ? -4.61584  -41.92348 11.62624  1.000 35.02424 ? 471 HOH A O   1 
HETATM 2405 O O   . HOH B 2 .   ? -32.86569 -35.30163 8.23399   1.000 34.88348 ? 472 HOH A O   1 
HETATM 2406 O O   . HOH B 2 .   ? -15.49619 -4.47490  39.40602  1.000 34.41281 ? 473 HOH A O   1 
HETATM 2407 O O   . HOH B 2 .   ? -19.10856 0.74237   34.62069  1.000 32.21430 ? 474 HOH A O   1 
HETATM 2408 O O   . HOH B 2 .   ? -29.55675 -17.12046 27.76974  1.000 28.67316 ? 475 HOH A O   1 
HETATM 2409 O O   . HOH B 2 .   ? -23.38240 -22.88859 -8.94307  1.000 38.25965 ? 476 HOH A O   1 
HETATM 2410 O O   . HOH B 2 .   ? -20.88311 -13.17587 44.40879  1.000 37.12227 ? 477 HOH A O   1 
HETATM 2411 O O   . HOH B 2 .   ? -30.06549 -30.60220 7.25156   1.000 31.75599 ? 478 HOH A O   1 
HETATM 2412 O O   . HOH B 2 .   ? -7.63907  -35.81769 3.44363   1.000 26.33492 ? 479 HOH A O   1 
HETATM 2413 O O   . HOH B 2 .   ? -21.06044 -20.00999 26.35181  1.000 19.46372 ? 480 HOH A O   1 
HETATM 2414 O O   . HOH B 2 .   ? -8.87077  -2.02357  41.05755  1.000 43.59179 ? 481 HOH A O   1 
HETATM 2415 O O   . HOH B 2 .   ? -2.40997  -15.24818 26.62664  1.000 44.55418 ? 482 HOH A O   1 
HETATM 2416 O O   . HOH B 2 .   ? -27.43359 0.44692   22.82264  1.000 34.44565 ? 483 HOH A O   1 
HETATM 2417 O O   . HOH B 2 .   ? -2.38819  -39.67246 15.64046  1.000 38.81815 ? 484 HOH A O   1 
HETATM 2418 O O   . HOH B 2 .   ? -26.50158 -17.38506 18.01035  1.000 30.71476 ? 485 HOH A O   1 
HETATM 2419 O O   . HOH B 2 .   ? -27.12393 -47.36670 -8.87450  1.000 39.07268 ? 486 HOH A O   1 
HETATM 2420 O O   . HOH B 2 .   ? -14.72622 -1.48058  22.82906  1.000 28.93514 ? 487 HOH A O   1 
HETATM 2421 O O   . HOH B 2 .   ? -19.46847 -20.29964 36.92043  1.000 23.24221 ? 488 HOH A O   1 
HETATM 2422 O O   . HOH B 2 .   ? -28.98005 -43.95897 7.27654   1.000 45.60113 ? 489 HOH A O   1 
HETATM 2423 O O   . HOH B 2 .   ? -33.30682 -11.67873 36.34933  1.000 27.47509 ? 490 HOH A O   1 
HETATM 2424 O O   . HOH B 2 .   ? -21.20899 -24.22218 10.23899  1.000 17.68649 ? 491 HOH A O   1 
HETATM 2425 O O   . HOH B 2 .   ? -29.18770 -27.50488 9.65430   1.000 29.76144 ? 492 HOH A O   1 
HETATM 2426 O O   . HOH B 2 .   ? -15.387   -16.947   48.067    1.000 29.86859 ? 493 HOH A O   1 
HETATM 2427 O O   . HOH B 2 .   ? -27.03911 -16.85873 14.49637  1.000 34.69999 ? 494 HOH A O   1 
HETATM 2428 O O   . HOH B 2 .   ? -12.91487 -55.25110 16.19801  1.000 40.24911 ? 495 HOH A O   1 
HETATM 2429 O O   . HOH B 2 .   ? -26.03327 -19.63198 39.95787  1.000 23.18369 ? 496 HOH A O   1 
HETATM 2430 O O   . HOH B 2 .   ? -7.90144  -32.72970 39.63615  1.000 46.26411 ? 497 HOH A O   1 
HETATM 2431 O O   . HOH B 2 .   ? -25.58128 -18.33194 -0.75836  1.000 31.46417 ? 498 HOH A O   1 
HETATM 2432 O O   . HOH B 2 .   ? -29.68161 -22.10631 3.40796   1.000 29.73065 ? 499 HOH A O   1 
HETATM 2433 O O   . HOH B 2 .   ? -11.47918 -26.16625 4.60512   1.000 33.63930 ? 500 HOH A O   1 
HETATM 2434 O O   . HOH B 2 .   ? -1.73748  -17.52066 32.61208  1.000 35.55746 ? 501 HOH A O   1 
HETATM 2435 O O   . HOH B 2 .   ? -29.06169 2.68538   31.68812  1.000 38.51193 ? 502 HOH A O   1 
HETATM 2436 O O   . HOH B 2 .   ? -1.61796  -12.69081 33.48192  1.000 40.93979 ? 503 HOH A O   1 
HETATM 2437 O O   . HOH B 2 .   ? -25.91766 -20.53614 2.55949   1.000 26.49369 ? 504 HOH A O   1 
HETATM 2438 O O   . HOH B 2 .   ? -30.88640 -31.52474 -10.36447 1.000 43.98475 ? 505 HOH A O   1 
HETATM 2439 O O   . HOH B 2 .   ? -11.85803 -53.20960 21.80892  1.000 42.66854 ? 506 HOH A O   1 
HETATM 2440 O O   . HOH B 2 .   ? -21.719   -23.071   35.818    1.000 35.63922 ? 507 HOH A O   1 
HETATM 2441 O O   . HOH B 2 .   ? -31.60067 -9.74507  29.50799  1.000 34.66654 ? 508 HOH A O   1 
HETATM 2442 O O   . HOH B 2 .   ? -25.17352 -4.42822  41.44693  1.000 31.64826 ? 509 HOH A O   1 
HETATM 2443 O O   . HOH B 2 .   ? -25.91721 -45.59053 -4.38105  1.000 21.17002 ? 510 HOH A O   1 
HETATM 2444 O O   . HOH B 2 .   ? -23.53247 -34.42931 16.38959  1.000 20.06016 ? 511 HOH A O   1 
HETATM 2445 O O   . HOH B 2 .   ? -27.07256 -41.14607 -11.20295 1.000 30.28006 ? 512 HOH A O   1 
HETATM 2446 O O   . HOH B 2 .   ? -7.67250  2.39744   25.81003  1.000 37.05681 ? 513 HOH A O   1 
HETATM 2447 O O   . HOH B 2 .   ? -13.72987 -16.30681 27.01504  1.000 15.33854 ? 514 HOH A O   1 
HETATM 2448 O O   . HOH B 2 .   ? -23.62602 -11.62118 6.08064   1.000 29.93449 ? 515 HOH A O   1 
HETATM 2449 O O   . HOH B 2 .   ? -8.21986  -38.70599 24.51662  1.000 23.35594 ? 516 HOH A O   1 
HETATM 2450 O O   . HOH B 2 .   ? -17.67162 -25.84407 27.63434  1.000 27.22960 ? 517 HOH A O   1 
HETATM 2451 O O   . HOH B 2 .   ? -26.40331 -17.90633 3.91969   1.000 22.25917 ? 518 HOH A O   1 
HETATM 2452 O O   . HOH B 2 .   ? -17.12204 -11.98151 16.24449  1.000 30.26002 ? 519 HOH A O   1 
HETATM 2453 O O   . HOH B 2 .   ? -8.84567  0.54641   30.59802  1.000 37.00106 ? 520 HOH A O   1 
HETATM 2454 O O   . HOH B 2 .   ? -25.92206 -16.66902 1.31191   1.000 25.45782 ? 521 HOH A O   1 
HETATM 2455 O O   . HOH B 2 .   ? -29.26429 -23.51310 18.64799  1.000 44.08143 ? 522 HOH A O   1 
HETATM 2456 O O   . HOH B 2 .   ? -7.76053  -1.21058  24.00623  1.000 44.47653 ? 523 HOH A O   1 
HETATM 2457 O O   . HOH B 2 .   ? -29.31689 -35.90565 2.20915   1.000 23.52173 ? 524 HOH A O   1 
HETATM 2458 O O   . HOH B 2 .   ? -25.91578 -28.63998 -1.19165  1.000 28.09823 ? 525 HOH A O   1 
HETATM 2459 O O   . HOH B 2 .   ? -29.94447 -5.73953  37.08021  1.000 32.09729 ? 526 HOH A O   1 
HETATM 2460 O O   . HOH B 2 .   ? -10.65261 -30.51284 31.54842  1.000 36.36904 ? 527 HOH A O   1 
HETATM 2461 O O   . HOH B 2 .   ? -13.044   -51.669   -3.564    1.000 32.11114 ? 528 HOH A O   1 
HETATM 2462 O O   . HOH B 2 .   ? -26.45886 -28.59167 2.06365   1.000 19.24286 ? 529 HOH A O   1 
HETATM 2463 O O   . HOH B 2 .   ? -21.92767 -21.77522 28.59736  1.000 31.96352 ? 530 HOH A O   1 
HETATM 2464 O O   . HOH B 2 .   ? -28.00924 -6.21560  24.65030  1.000 34.19471 ? 531 HOH A O   1 
HETATM 2465 O O   . HOH B 2 .   ? -27.29691 -25.26900 17.61378  1.000 32.23844 ? 532 HOH A O   1 
HETATM 2466 O O   . HOH B 2 .   ? -1.66729  -6.95652  32.99402  1.000 39.74940 ? 533 HOH A O   1 
HETATM 2467 O O   . HOH B 2 .   ? -20.18593 -52.88741 -4.31320  1.000 27.79697 ? 534 HOH A O   1 
HETATM 2468 O O   . HOH B 2 .   ? -18.75152 -26.45384 25.34714  1.000 28.62915 ? 535 HOH A O   1 
HETATM 2469 O O   . HOH B 2 .   ? -10.30640 -24.85987 29.98495  1.000 26.52346 ? 536 HOH A O   1 
HETATM 2470 O O   . HOH B 2 .   ? -25.93614 -49.68071 0.92131   1.000 29.86198 ? 537 HOH A O   1 
HETATM 2471 O O   . HOH B 2 .   ? -21.34401 -45.81804 14.81115  1.000 22.71895 ? 538 HOH A O   1 
HETATM 2472 O O   . HOH B 2 .   ? -29.05599 -10.48455 37.11279  1.000 22.06201 ? 539 HOH A O   1 
HETATM 2473 O O   . HOH B 2 .   ? -28.59610 -42.99554 0.97255   1.000 20.86469 ? 540 HOH A O   1 
HETATM 2474 O O   . HOH B 2 .   ? -6.03912  -43.27206 9.11376   1.000 35.68607 ? 541 HOH A O   1 
HETATM 2475 O O   . HOH B 2 .   ? -4.13768  -3.36479  24.88278  1.000 39.44819 ? 542 HOH A O   1 
HETATM 2476 O O   . HOH B 2 .   ? -22.39909 -34.20075 26.05743  1.000 37.72755 ? 543 HOH A O   1 
HETATM 2477 O O   . HOH B 2 .   ? -20.04036 3.69357   24.65742  1.000 39.96316 ? 544 HOH A O   1 
HETATM 2478 O O   . HOH B 2 .   ? -19.39229 -15.80878 0.75878   1.000 40.49893 ? 545 HOH A O   1 
HETATM 2479 O O   . HOH B 2 .   ? -27.40065 -27.51612 4.41010   1.000 18.35667 ? 546 HOH A O   1 
HETATM 2480 O O   . HOH B 2 .   ? -20.52451 -32.52093 2.24693   1.000 17.72772 ? 547 HOH A O   1 
HETATM 2481 O O   . HOH B 2 .   ? -32.01034 -17.89307 27.90273  1.000 39.66563 ? 548 HOH A O   1 
HETATM 2482 O O   . HOH B 2 .   ? -12.06155 -23.12123 25.51028  1.000 26.75958 ? 549 HOH A O   1 
HETATM 2483 O O   . HOH B 2 .   ? -15.46992 -51.75457 19.42453  1.000 28.88275 ? 550 HOH A O   1 
HETATM 2484 O O   . HOH B 2 .   ? -28.40570 -32.48834 -3.87219  1.000 27.03241 ? 551 HOH A O   1 
HETATM 2485 O O   . HOH B 2 .   ? -19.41975 -31.74725 22.10729  1.000 21.15072 ? 552 HOH A O   1 
HETATM 2486 O O   . HOH B 2 .   ? -26.95744 -6.85394  22.23973  1.000 35.05435 ? 553 HOH A O   1 
HETATM 2487 O O   . HOH B 2 .   ? -28.97686 -40.30666 13.42578  1.000 34.97598 ? 554 HOH A O   1 
HETATM 2488 O O   . HOH B 2 .   ? -31.24457 -37.43348 4.99780   1.000 27.14237 ? 555 HOH A O   1 
HETATM 2489 O O   . HOH B 2 .   ? -11.05414 -18.24148 9.89848   1.000 32.52907 ? 556 HOH A O   1 
HETATM 2490 O O   . HOH B 2 .   ? -13.99822 -35.44097 33.15084  1.000 43.47935 ? 557 HOH A O   1 
HETATM 2491 O O   . HOH B 2 .   ? 0.48279   -29.45542 15.08373  1.000 26.42649 ? 558 HOH A O   1 
HETATM 2492 O O   . HOH B 2 .   ? -21.41340 1.54787   35.60953  1.000 27.59824 ? 559 HOH A O   1 
HETATM 2493 O O   . HOH B 2 .   ? -5.07633  -17.74281 27.87624  1.000 40.13559 ? 560 HOH A O   1 
HETATM 2494 O O   . HOH B 2 .   ? -32.06615 -38.15617 14.10786  1.000 45.90975 ? 561 HOH A O   1 
HETATM 2495 O O   . HOH B 2 .   ? -19.46114 -0.50458  18.02106  1.000 39.16169 ? 562 HOH A O   1 
HETATM 2496 O O   . HOH B 2 .   ? -23.54614 -14.28886 26.26842  1.000 23.00131 ? 563 HOH A O   1 
HETATM 2497 O O   . HOH B 2 .   ? -21.38962 -54.88165 -1.03162  1.000 29.93464 ? 564 HOH A O   1 
HETATM 2498 O O   . HOH B 2 .   ? -27.80811 -29.20684 6.56594   1.000 19.18227 ? 565 HOH A O   1 
HETATM 2499 O O   . HOH B 2 .   ? -6.05999  -25.14690 1.13539   1.000 43.06414 ? 566 HOH A O   1 
HETATM 2500 O O   . HOH B 2 .   ? -6.16776  -15.16335 27.71034  1.000 28.51422 ? 567 HOH A O   1 
HETATM 2501 O O   . HOH B 2 .   ? -17.92309 -15.41396 10.87728  1.000 28.80079 ? 568 HOH A O   1 
HETATM 2502 O O   . HOH B 2 .   ? -6.17574  -24.63614 21.78818  1.000 23.40661 ? 569 HOH A O   1 
HETATM 2503 O O   . HOH B 2 .   ? -14.55014 -25.64422 1.05687   1.000 31.89563 ? 570 HOH A O   1 
HETATM 2504 O O   . HOH B 2 .   ? -12.28118 -2.50817  24.43435  1.000 34.15997 ? 571 HOH A O   1 
HETATM 2505 O O   . HOH B 2 .   ? -22.23649 -43.09334 25.34181  1.000 35.19560 ? 572 HOH A O   1 
HETATM 2506 O O   . HOH B 2 .   ? -23.86701 -12.40989 41.15801  1.000 35.91171 ? 573 HOH A O   1 
HETATM 2507 O O   . HOH B 2 .   ? -24.94671 -9.83077  40.18456  1.000 24.81202 ? 574 HOH A O   1 
HETATM 2508 O O   . HOH B 2 .   ? -20.32405 -23.12717 30.39285  1.000 25.50699 ? 575 HOH A O   1 
HETATM 2509 O O   . HOH B 2 .   ? -18.50624 -15.22690 47.55568  1.000 35.95644 ? 576 HOH A O   1 
HETATM 2510 O O   . HOH B 2 .   ? -24.81128 -13.01813 15.98718  1.000 38.04869 ? 577 HOH A O   1 
HETATM 2511 O O   . HOH B 2 .   ? -28.20069 -23.93356 12.81081  1.000 34.26841 ? 578 HOH A O   1 
HETATM 2512 O O   . HOH B 2 .   ? -28.66092 -41.33841 -3.59946  1.000 20.37159 ? 579 HOH A O   1 
HETATM 2513 O O   . HOH B 2 .   ? -15.82675 -43.93714 -7.99193  1.000 39.30094 ? 580 HOH A O   1 
HETATM 2514 O O   . HOH B 2 .   ? -32.88929 -12.28915 31.65775  1.000 25.96682 ? 581 HOH A O   1 
HETATM 2515 O O   . HOH B 2 .   ? -31.76636 -37.78802 10.20660  1.000 25.94872 ? 582 HOH A O   1 
HETATM 2516 O O   . HOH B 2 .   ? -19.64761 4.59450   34.26109  1.000 45.00558 ? 583 HOH A O   1 
HETATM 2517 O O   . HOH B 2 .   ? -14.83646 -8.37239  20.66558  1.000 33.93834 ? 584 HOH A O   1 
HETATM 2518 O O   . HOH B 2 .   ? -13.376   1.810     23.446    1.000 33.01238 ? 585 HOH A O   1 
HETATM 2519 O O   . HOH B 2 .   ? -27.23294 -43.90514 12.30642  1.000 47.84225 ? 586 HOH A O   1 
HETATM 2520 O O   . HOH B 2 .   ? -24.53587 -33.17272 -9.98450  1.000 28.09748 ? 587 HOH A O   1 
HETATM 2521 O O   . HOH B 2 .   ? -6.90855  -17.58888 43.46503  1.000 36.14682 ? 588 HOH A O   1 
HETATM 2522 O O   . HOH B 2 .   ? -15.48125 3.26001   22.00692  1.000 29.43205 ? 589 HOH A O   1 
HETATM 2523 O O   . HOH B 2 .   ? -14.78003 -27.91571 0.90104   1.000 37.58239 ? 590 HOH A O   1 
HETATM 2524 O O   . HOH B 2 .   ? -13.77770 -13.11103 19.31584  1.000 32.51691 ? 591 HOH A O   1 
HETATM 2525 O O   . HOH B 2 .   ? -13.78888 -44.63955 26.20098  1.000 27.66397 ? 592 HOH A O   1 
HETATM 2526 O O   . HOH B 2 .   ? -11.71921 -6.63607  22.57814  1.000 20.58974 ? 593 HOH A O   1 
HETATM 2527 O O   . HOH B 2 .   ? -15.10727 -52.79756 0.10098   1.000 36.95534 ? 594 HOH A O   1 
HETATM 2528 O O   . HOH B 2 .   ? -19.25947 -41.62443 -10.48979 1.000 43.46633 ? 595 HOH A O   1 
HETATM 2529 O O   . HOH B 2 .   ? -28.60658 -30.98189 -1.36704  1.000 31.22907 ? 596 HOH A O   1 
HETATM 2530 O O   . HOH B 2 .   ? -25.56261 -40.24875 20.30283  1.000 32.44231 ? 597 HOH A O   1 
HETATM 2531 O O   . HOH B 2 .   ? -20.50071 -13.31778 5.22495   1.000 33.72303 ? 598 HOH A O   1 
HETATM 2532 O O   . HOH B 2 .   ? -10.09070 -0.21227  36.67643  1.000 47.27195 ? 599 HOH A O   1 
HETATM 2533 O O   . HOH B 2 .   ? -16.68305 -59.50314 5.15665   1.000 43.09430 ? 600 HOH A O   1 
HETATM 2534 O O   . HOH B 2 .   ? -11.02209 -31.64266 2.22638   1.000 38.89351 ? 601 HOH A O   1 
HETATM 2535 O O   . HOH B 2 .   ? -30.41345 -38.56566 2.33977   1.000 25.41650 ? 602 HOH A O   1 
HETATM 2536 O O   . HOH B 2 .   ? -22.90641 -44.76303 21.61075  1.000 47.17227 ? 603 HOH A O   1 
HETATM 2537 O O   . HOH B 2 .   ? -28.54814 -24.96989 15.48125  1.000 32.31027 ? 604 HOH A O   1 
HETATM 2538 O O   . HOH B 2 .   ? -3.56782  -6.46068  37.63043  1.000 38.03041 ? 605 HOH A O   1 
HETATM 2539 O O   . HOH B 2 .   ? -8.22347  -49.11129 14.89381  1.000 30.82675 ? 606 HOH A O   1 
HETATM 2540 O O   . HOH B 2 .   ? -4.27700  -10.13468 21.87684  0.50  18.81666 ? 607 HOH A O   1 
HETATM 2541 O O   . HOH B 2 .   ? -24.82412 -47.09113 6.26143   1.000 33.12189 ? 608 HOH A O   1 
HETATM 2542 O O   . HOH B 2 .   ? -18.69867 -9.42661  16.28612  1.000 34.56091 ? 609 HOH A O   1 
HETATM 2543 O O   . HOH B 2 .   ? -23.62851 -50.98091 -3.38622  1.000 26.56309 ? 610 HOH A O   1 
HETATM 2544 O O   . HOH B 2 .   ? -25.78835 -48.24876 -5.35242  1.000 41.94939 ? 611 HOH A O   1 
HETATM 2545 O O   . HOH B 2 .   ? -21.88851 2.57877   25.75022  1.000 35.44568 ? 612 HOH A O   1 
HETATM 2546 O O   . HOH B 2 .   ? -31.94403 -35.32687 10.74193  1.000 42.04057 ? 613 HOH A O   1 
HETATM 2547 O O   . HOH B 2 .   ? -30.84348 -35.74449 17.05096  1.000 40.75727 ? 614 HOH A O   1 
HETATM 2548 O O   . HOH B 2 .   ? -29.63185 -24.64134 10.29476  1.000 39.31492 ? 615 HOH A O   1 
HETATM 2549 O O   . HOH B 2 .   ? -26.45883 -39.28011 -12.94488 1.000 46.35785 ? 616 HOH A O   1 
HETATM 2550 O O   . HOH B 2 .   ? -31.73438 -4.54466  35.23803  1.000 29.60173 ? 617 HOH A O   1 
HETATM 2551 O O   . HOH B 2 .   ? -15.77539 -11.42229 18.46741  1.000 39.40629 ? 618 HOH A O   1 
HETATM 2552 O O   . HOH B 2 .   ? -20.48256 -45.57970 22.91518  1.000 31.67635 ? 619 HOH A O   1 
HETATM 2553 O O   . HOH B 2 .   ? -25.20704 -35.60293 -11.36919 1.000 28.64786 ? 620 HOH A O   1 
HETATM 2554 O O   . HOH B 2 .   ? -14.92838 -32.56763 -3.10807  1.000 34.32345 ? 621 HOH A O   1 
HETATM 2555 O O   . HOH B 2 .   ? -25.38860 -50.21650 -6.59854  1.000 50.14557 ? 622 HOH A O   1 
HETATM 2556 O O   . HOH B 2 .   ? -28.49014 -12.92429 40.01054  1.000 19.86638 ? 623 HOH A O   1 
HETATM 2557 O O   . HOH B 2 .   ? -30.562   -44.845   2.784     1.000 44.95739 ? 624 HOH A O   1 
HETATM 2558 O O   . HOH B 2 .   ? -16.20619 -38.87688 -8.04799  1.000 40.07387 ? 625 HOH A O   1 
HETATM 2559 O O   . HOH B 2 .   ? -17.053   -57.034   -0.144    1.000 37.88033 ? 626 HOH A O   1 
HETATM 2560 O O   . HOH B 2 .   ? -20.75335 -37.26896 28.59210  1.000 43.03783 ? 627 HOH A O   1 
HETATM 2561 O O   . HOH B 2 .   ? -25.56012 -51.92644 0.10507   1.000 40.33766 ? 628 HOH A O   1 
HETATM 2562 O O   . HOH B 2 .   ? -27.53650 -47.54689 -0.81890  1.000 33.15954 ? 629 HOH A O   1 
HETATM 2563 O O   . HOH B 2 .   ? -9.89111  -24.03228 27.08816  1.000 24.18325 ? 630 HOH A O   1 
HETATM 2564 O O   . HOH B 2 .   ? -2.85600  -29.66439 2.67432   1.000 45.15232 ? 631 HOH A O   1 
HETATM 2565 O O   . HOH B 2 .   ? -24.03175 -17.43164 21.56547  1.000 39.90011 ? 632 HOH A O   1 
HETATM 2566 O O   . HOH B 2 .   ? -27.78808 -24.61506 -2.79500  1.000 43.20882 ? 633 HOH A O   1 
HETATM 2567 O O   . HOH B 2 .   ? -4.27700  -26.66408 21.87684  0.50  34.33519 ? 634 HOH A O   1 
HETATM 2568 O O   . HOH B 2 .   ? -25.92967 -16.98978 20.40755  1.000 38.90314 ? 635 HOH A O   1 
HETATM 2569 O O   . HOH B 2 .   ? -32.66244 -36.48502 -7.46176  1.000 38.34938 ? 636 HOH A O   1 
HETATM 2570 O O   . HOH B 2 .   ? -31.11331 0.69385   31.94405  1.000 45.63952 ? 637 HOH A O   1 
HETATM 2571 O O   . HOH B 2 .   ? -30.291   -24.042   -5.182    1.000 49.16464 ? 638 HOH A O   1 
HETATM 2572 O O   . HOH B 2 .   ? -33.79098 -17.59277 34.86681  1.000 51.60503 ? 639 HOH A O   1 
HETATM 2573 O O   . HOH B 2 .   ? -20.56849 -32.63733 31.42770  1.000 56.58428 ? 640 HOH A O   1 
HETATM 2574 O O   . HOH B 2 .   ? -27.94979 -19.27200 28.14336  1.000 43.39402 ? 641 HOH A O   1 
HETATM 2575 O O   . HOH B 2 .   ? -4.16634  -42.81456 7.63540   1.000 47.88710 ? 642 HOH A O   1 
HETATM 2576 O O   . HOH B 2 .   ? -25.87271 -49.09811 4.89273   1.000 38.33129 ? 643 HOH A O   1 
HETATM 2577 O O   . HOH B 2 .   ? -26.74299 -31.35787 -11.07943 1.000 43.91899 ? 644 HOH A O   1 
HETATM 2578 O O   . HOH B 2 .   ? -25.43306 -23.37119 25.95043  1.000 40.42789 ? 645 HOH A O   1 
HETATM 2579 O O   . HOH B 2 .   ? -30.943   -40.374   6.626     1.000 36.63502 ? 646 HOH A O   1 
HETATM 2580 O O   . HOH B 2 .   ? -29.65308 -30.94399 -5.65997  1.000 39.25836 ? 647 HOH A O   1 
HETATM 2581 O O   . HOH B 2 .   ? -23.850   -14.278   -0.383    1.000 37.41693 ? 648 HOH A O   1 
HETATM 2582 O O   . HOH B 2 .   ? -14.94484 -5.17581  41.59331  1.000 35.45974 ? 649 HOH A O   1 
HETATM 2583 O O   . HOH B 2 .   ? -24.56216 2.45690   25.69609  1.000 43.80161 ? 650 HOH A O   1 
HETATM 2584 O O   . HOH B 2 .   ? -21.63271 -13.76300 0.67106   1.000 34.60977 ? 651 HOH A O   1 
HETATM 2585 O O   . HOH B 2 .   ? -27.47218 -44.75440 -0.91680  1.000 20.94494 ? 652 HOH A O   1 
HETATM 2586 O O   . HOH B 2 .   ? -32.60637 -14.30888 39.99821  1.000 42.13937 ? 653 HOH A O   1 
HETATM 2587 O O   . HOH B 2 .   ? -20.704   -52.659   15.761    1.000 38.82356 ? 654 HOH A O   1 
HETATM 2588 O O   . HOH B 2 .   ? -25.69589 -46.80657 8.39286   1.000 46.43191 ? 655 HOH A O   1 
HETATM 2589 O O   . HOH B 2 .   ? -1.52731  -16.53949 35.35986  1.000 40.81526 ? 656 HOH A O   1 
HETATM 2590 O O   . HOH B 2 .   ? -12.75051 -54.61338 0.22372   1.000 41.59693 ? 657 HOH A O   1 
HETATM 2591 O O   . HOH B 2 .   ? -33.10049 -1.62550  34.34196  1.000 49.72682 ? 658 HOH A O   1 
HETATM 2592 O O   . HOH B 2 .   ? -8.47751  -17.67861 14.07765  1.000 44.81588 ? 659 HOH A O   1 
HETATM 2593 O O   . HOH B 2 .   ? -25.18302 -19.89943 27.76524  1.000 39.97476 ? 660 HOH A O   1 
HETATM 2594 O O   . HOH B 2 .   ? -29.25960 -15.76744 25.13351  1.000 37.59123 ? 661 HOH A O   1 
HETATM 2595 O O   . HOH B 2 .   ? -24.411   -20.947   41.634    1.000 34.67388 ? 662 HOH A O   1 
HETATM 2596 O O   . HOH B 2 .   ? -12.861   -23.791   -0.640    1.000 36.33566 ? 663 HOH A O   1 
HETATM 2597 O O   . HOH B 2 .   ? -24.88137 -22.42350 28.50022  1.000 45.43023 ? 664 HOH A O   1 
HETATM 2598 O O   . HOH B 2 .   ? -31.02642 -12.83723 40.88509  1.000 34.34256 ? 665 HOH A O   1 
HETATM 2599 O O   . HOH B 2 .   ? -19.84978 -29.25787 26.20697  1.000 43.61124 ? 666 HOH A O   1 
HETATM 2600 O O   . HOH B 2 .   ? -26.58042 -41.23156 13.73406  1.000 31.45185 ? 667 HOH A O   1 
HETATM 2601 O O   . HOH B 2 .   ? -9.82385  -48.67857 23.27646  1.000 46.88724 ? 668 HOH A O   1 
HETATM 2602 O O   . HOH B 2 .   ? -26.17251 -34.80670 16.68022  1.000 33.38566 ? 669 HOH A O   1 
HETATM 2603 O O   . HOH B 2 .   ? -20.30139 -8.49993  46.15530  1.000 50.03281 ? 670 HOH A O   1 
HETATM 2604 O O   . HOH B 2 .   ? -24.76561 -43.22198 18.16521  1.000 46.11284 ? 671 HOH A O   1 
HETATM 2605 O O   . HOH B 2 .   ? -17.03794 -6.27877  17.64822  1.000 45.08541 ? 672 HOH A O   1 
HETATM 2606 O O   . HOH B 2 .   ? -30.33073 -33.22845 2.41073   1.000 42.84243 ? 673 HOH A O   1 
HETATM 2607 O O   . HOH B 2 .   ? -24.04874 -15.84407 24.26691  1.000 37.21723 ? 674 HOH A O   1 
HETATM 2608 O O   . HOH B 2 .   ? -28.832   -20.039   11.364    1.000 31.83043 ? 675 HOH A O   1 
HETATM 2609 O O   . HOH B 2 .   ? -23.54131 -19.06952 25.59355  1.000 28.49786 ? 676 HOH A O   1 
HETATM 2610 O O   . HOH B 2 .   ? -32.47780 -29.86159 7.17393   1.000 43.80831 ? 677 HOH A O   1 
HETATM 2611 O O   . HOH B 2 .   ? -10.95183 -0.37821  33.53530  1.000 44.70171 ? 678 HOH A O   1 
HETATM 2612 O O   . HOH B 2 .   ? -27.96166 -28.12713 -0.26981  1.000 37.17074 ? 679 HOH A O   1 
HETATM 2613 O O   . HOH B 2 .   ? -13.166   -11.761   2.161     1.000 46.72787 ? 680 HOH A O   1 
HETATM 2614 O O   . HOH B 2 .   ? -29.35894 -31.84559 3.93156   1.000 44.46686 ? 681 HOH A O   1 
HETATM 2615 O O   . HOH B 2 .   ? -26.81552 -20.66130 0.00620   1.000 35.77744 ? 682 HOH A O   1 
HETATM 2616 O O   . HOH B 2 .   ? -28.26181 -44.13633 -3.47018  1.000 21.98599 ? 683 HOH A O   1 
HETATM 2617 O O   . HOH B 2 .   ? -21.15715 -31.50474 24.52104  1.000 38.91412 ? 684 HOH A O   1 
HETATM 2618 O O   . HOH B 2 .   ? -11.05074 -26.30261 2.30179   1.000 42.30135 ? 685 HOH A O   1 
HETATM 2619 O O   . HOH B 2 .   ? -10.278   -25.573   -4.284    1.000 34.18276 ? 686 HOH A O   1 
HETATM 2620 O O   . HOH B 2 .   ? -27.42610 -17.73446 11.86819  1.000 27.66471 ? 687 HOH A O   1 
HETATM 2621 O O   . HOH B 2 .   ? -17.40976 -1.78812  18.54359  1.000 33.45174 ? 688 HOH A O   1 
HETATM 2622 O O   . HOH B 2 .   ? 0.47943   0.66376   30.88140  1.000 40.19560 ? 689 HOH A O   1 
HETATM 2623 O O   . HOH B 2 .   ? -19.11625 -54.89098 -2.52837  1.000 28.86217 ? 690 HOH A O   1 
HETATM 2624 O O   . HOH B 2 .   ? -22.77233 -53.58473 -4.44630  1.000 37.80300 ? 691 HOH A O   1 
HETATM 2625 O O   . HOH B 2 .   ? -24.90222 -45.26912 20.12027  1.000 53.35244 ? 692 HOH A O   1 
HETATM 2626 O O   . HOH B 2 .   ? -7.949    -24.095   -3.122    1.000 39.75265 ? 693 HOH A O   1 
HETATM 2627 O O   . HOH B 2 .   ? -30.75118 -8.34731  37.34899  1.000 24.44064 ? 694 HOH A O   1 
HETATM 2628 O O   . HOH B 2 .   ? -11.622   -25.693   -2.122    1.000 42.36866 ? 695 HOH A O   1 
HETATM 2629 O O   . HOH B 2 .   ? -30.433   -25.445   6.362     1.000 40.86593 ? 696 HOH A O   1 
HETATM 2630 O O   . HOH B 2 .   ? -31.26127 -39.53348 0.07772   1.000 35.21614 ? 697 HOH A O   1 
HETATM 2631 O O   . HOH B 2 .   ? -14.85966 -54.21607 19.51553  1.000 38.47369 ? 698 HOH A O   1 
HETATM 2632 O O   . HOH B 2 .   ? -30.73321 -6.12338  24.58776  1.000 34.27374 ? 699 HOH A O   1 
HETATM 2633 O O   . HOH B 2 .   ? -29.96666 -26.63030 4.02248   1.000 28.78354 ? 700 HOH A O   1 
HETATM 2634 O O   . HOH B 2 .   ? -26.080   -51.280   -2.859    1.000 41.17575 ? 701 HOH A O   1 
HETATM 2635 O O   . HOH B 2 .   ? -31.51004 -12.37931 24.79739  1.000 38.63098 ? 702 HOH A O   1 
HETATM 2636 O O   . HOH B 2 .   ? -11.85661 -9.17183  19.28193  1.000 39.80992 ? 703 HOH A O   1 
HETATM 2637 O O   . HOH B 2 .   ? -29.13448 -44.86772 13.30601  1.000 46.82996 ? 704 HOH A O   1 
HETATM 2638 O O   . HOH B 2 .   ? -28.30936 -4.56218  17.70804  1.000 52.22428 ? 705 HOH A O   1 
HETATM 2639 O O   . HOH B 2 .   ? -29.68581 -4.73002  39.80559  1.000 33.82522 ? 706 HOH A O   1 
HETATM 2640 O O   . HOH B 2 .   ? -10.81683 -4.12670  23.22501  1.000 38.06758 ? 707 HOH A O   1 
HETATM 2641 O O   . HOH B 2 .   ? -27.562   -14.307   0.994     1.000 25.04850 ? 708 HOH A O   1 
HETATM 2642 O O   . HOH B 2 .   ? -15.15929 -4.03709  21.72565  1.000 28.42860 ? 709 HOH A O   1 
HETATM 2643 O O   . HOH B 2 .   ? -27.66423 -10.46807 39.49208  1.000 24.37299 ? 710 HOH A O   1 
HETATM 2644 O O   . HOH B 2 .   ? -28.90165 -19.00905 17.81191  1.000 49.19920 ? 711 HOH A O   1 
HETATM 2645 O O   . HOH B 2 .   ? -25.92419 -14.13712 41.12302  1.000 28.51690 ? 712 HOH A O   1 
HETATM 2646 O O   . HOH B 2 .   ? -8.55400  -5.98046  43.75367  0.50  36.07319 ? 713 HOH A O   1 
HETATM 2647 O O   . HOH B 2 .   ? -28.78126 -7.82185  20.19110  1.000 42.01619 ? 714 HOH A O   1 
HETATM 2648 O O   . HOH B 2 .   ? -26.74058 -40.45935 22.88295  1.000 46.96163 ? 715 HOH A O   1 
HETATM 2649 O O   . HOH B 2 .   ? -34.132   -36.964   2.144     1.000 35.58712 ? 716 HOH A O   1 
HETATM 2650 O O   . HOH B 2 .   ? -31.80095 -7.68621  22.42039  1.000 36.32507 ? 717 HOH A O   1 
HETATM 2651 O O   . HOH B 2 .   ? -29.49632 -6.46375  41.41639  1.000 46.28835 ? 718 HOH A O   1 
HETATM 2652 O O   . HOH B 2 .   ? -28.80519 -8.89946  41.37217  1.000 40.59500 ? 719 HOH A O   1 
# 
