data_9BNT
# 
_entry.id   9BNT 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BNT         pdb_00009bnt 10.2210/pdb9bnt/pdb 
WWPDB D_1000282919 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-12 ? 
2 'Structure model' 1 1 2025-03-12 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
_pdbx_audit_revision_category.ordinal             1 
_pdbx_audit_revision_category.revision_ordinal    2 
_pdbx_audit_revision_category.data_content_type   'Structure model' 
_pdbx_audit_revision_category.category            citation 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
5 2 'Structure model' '_citation.title'                   
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BNT 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-03 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              karen.anderson@yale.edu 
_pdbx_contact_author.name_first         Karen 
_pdbx_contact_author.name_last          Anderson 
_pdbx_contact_author.name_mi            S 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3433-0780 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Papini, C.'     1 0000-0002-6098-4959 
'Anderson, K.S.' 2 0000-0003-3433-0780 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acs Bio Med Chem Au' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2694-2437 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            5 
_citation.language                  ? 
_citation.page_first                215 
_citation.page_last                 226 
_citation.title                     
'Exploring Possible Drug-Resistant Variants of SARS-CoV-2 Main Protease (M pro ) with Noncovalent Preclinical Candidate, Mpro61.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acsbiomedchemau.4c00109 
_citation.pdbx_database_id_PubMed   39990941 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kenneson, J.R.'  1 ? 
primary 'Papini, C.'      2 ? 
primary 'Tang, S.'        3 ? 
primary 'Huynh, K.'       4 ? 
primary 'Zhang, C.H.'     5 ? 
primary 'Jorgensen, W.L.' 6 ? 
primary 'Anderson, K.S.'  7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man '3C-like proteinase' 33837.602 1   3.4.22.69 ? ? ? 
2 water   nat water                18.015    109 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO, 3CLp, Main protease, Mpro, Non-structural protein 5, nsp5, SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SGFRKMAFPSGKVEGCMVQVICGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SGFRKMAFPSGKVEGCMVQVICGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   GLY n 
1 3   PHE n 
1 4   ARG n 
1 5   LYS n 
1 6   MET n 
1 7   ALA n 
1 8   PHE n 
1 9   PRO n 
1 10  SER n 
1 11  GLY n 
1 12  LYS n 
1 13  VAL n 
1 14  GLU n 
1 15  GLY n 
1 16  CYS n 
1 17  MET n 
1 18  VAL n 
1 19  GLN n 
1 20  VAL n 
1 21  ILE n 
1 22  CYS n 
1 23  GLY n 
1 24  THR n 
1 25  THR n 
1 26  THR n 
1 27  LEU n 
1 28  ASN n 
1 29  GLY n 
1 30  LEU n 
1 31  TRP n 
1 32  LEU n 
1 33  ASP n 
1 34  ASP n 
1 35  VAL n 
1 36  VAL n 
1 37  TYR n 
1 38  CYS n 
1 39  PRO n 
1 40  ARG n 
1 41  HIS n 
1 42  VAL n 
1 43  ILE n 
1 44  CYS n 
1 45  THR n 
1 46  SER n 
1 47  GLU n 
1 48  ASP n 
1 49  MET n 
1 50  LEU n 
1 51  ASN n 
1 52  PRO n 
1 53  ASN n 
1 54  TYR n 
1 55  GLU n 
1 56  ASP n 
1 57  LEU n 
1 58  LEU n 
1 59  ILE n 
1 60  ARG n 
1 61  LYS n 
1 62  SER n 
1 63  ASN n 
1 64  HIS n 
1 65  ASN n 
1 66  PHE n 
1 67  LEU n 
1 68  VAL n 
1 69  GLN n 
1 70  ALA n 
1 71  GLY n 
1 72  ASN n 
1 73  VAL n 
1 74  GLN n 
1 75  LEU n 
1 76  ARG n 
1 77  VAL n 
1 78  ILE n 
1 79  GLY n 
1 80  HIS n 
1 81  SER n 
1 82  MET n 
1 83  GLN n 
1 84  ASN n 
1 85  CYS n 
1 86  VAL n 
1 87  LEU n 
1 88  LYS n 
1 89  LEU n 
1 90  LYS n 
1 91  VAL n 
1 92  ASP n 
1 93  THR n 
1 94  ALA n 
1 95  ASN n 
1 96  PRO n 
1 97  LYS n 
1 98  THR n 
1 99  PRO n 
1 100 LYS n 
1 101 TYR n 
1 102 LYS n 
1 103 PHE n 
1 104 VAL n 
1 105 ARG n 
1 106 ILE n 
1 107 GLN n 
1 108 PRO n 
1 109 GLY n 
1 110 GLN n 
1 111 THR n 
1 112 PHE n 
1 113 SER n 
1 114 VAL n 
1 115 LEU n 
1 116 ALA n 
1 117 CYS n 
1 118 TYR n 
1 119 ASN n 
1 120 GLY n 
1 121 SER n 
1 122 PRO n 
1 123 SER n 
1 124 GLY n 
1 125 VAL n 
1 126 TYR n 
1 127 GLN n 
1 128 CYS n 
1 129 ALA n 
1 130 MET n 
1 131 ARG n 
1 132 PRO n 
1 133 ASN n 
1 134 PHE n 
1 135 THR n 
1 136 ILE n 
1 137 LYS n 
1 138 GLY n 
1 139 SER n 
1 140 PHE n 
1 141 LEU n 
1 142 ASN n 
1 143 GLY n 
1 144 SER n 
1 145 CYS n 
1 146 GLY n 
1 147 SER n 
1 148 VAL n 
1 149 GLY n 
1 150 PHE n 
1 151 ASN n 
1 152 ILE n 
1 153 ASP n 
1 154 TYR n 
1 155 ASP n 
1 156 CYS n 
1 157 VAL n 
1 158 SER n 
1 159 PHE n 
1 160 CYS n 
1 161 TYR n 
1 162 MET n 
1 163 HIS n 
1 164 HIS n 
1 165 MET n 
1 166 GLU n 
1 167 LEU n 
1 168 PRO n 
1 169 THR n 
1 170 GLY n 
1 171 VAL n 
1 172 HIS n 
1 173 ALA n 
1 174 GLY n 
1 175 THR n 
1 176 ASP n 
1 177 LEU n 
1 178 GLU n 
1 179 GLY n 
1 180 ASN n 
1 181 PHE n 
1 182 TYR n 
1 183 GLY n 
1 184 PRO n 
1 185 PHE n 
1 186 VAL n 
1 187 ASP n 
1 188 ARG n 
1 189 GLN n 
1 190 THR n 
1 191 ALA n 
1 192 GLN n 
1 193 ALA n 
1 194 ALA n 
1 195 GLY n 
1 196 THR n 
1 197 ASP n 
1 198 THR n 
1 199 THR n 
1 200 ILE n 
1 201 THR n 
1 202 VAL n 
1 203 ASN n 
1 204 VAL n 
1 205 LEU n 
1 206 ALA n 
1 207 TRP n 
1 208 LEU n 
1 209 TYR n 
1 210 ALA n 
1 211 ALA n 
1 212 VAL n 
1 213 ILE n 
1 214 ASN n 
1 215 GLY n 
1 216 ASP n 
1 217 ARG n 
1 218 TRP n 
1 219 PHE n 
1 220 LEU n 
1 221 ASN n 
1 222 ARG n 
1 223 PHE n 
1 224 THR n 
1 225 THR n 
1 226 THR n 
1 227 LEU n 
1 228 ASN n 
1 229 ASP n 
1 230 PHE n 
1 231 ASN n 
1 232 LEU n 
1 233 VAL n 
1 234 ALA n 
1 235 MET n 
1 236 LYS n 
1 237 TYR n 
1 238 ASN n 
1 239 TYR n 
1 240 GLU n 
1 241 PRO n 
1 242 LEU n 
1 243 THR n 
1 244 GLN n 
1 245 ASP n 
1 246 HIS n 
1 247 VAL n 
1 248 ASP n 
1 249 ILE n 
1 250 LEU n 
1 251 GLY n 
1 252 PRO n 
1 253 LEU n 
1 254 SER n 
1 255 ALA n 
1 256 GLN n 
1 257 THR n 
1 258 GLY n 
1 259 ILE n 
1 260 ALA n 
1 261 VAL n 
1 262 LEU n 
1 263 ASP n 
1 264 MET n 
1 265 CYS n 
1 266 ALA n 
1 267 SER n 
1 268 LEU n 
1 269 LYS n 
1 270 GLU n 
1 271 LEU n 
1 272 LEU n 
1 273 GLN n 
1 274 ASN n 
1 275 GLY n 
1 276 MET n 
1 277 ASN n 
1 278 GLY n 
1 279 ARG n 
1 280 THR n 
1 281 ILE n 
1 282 LEU n 
1 283 GLY n 
1 284 SER n 
1 285 ALA n 
1 286 LEU n 
1 287 LEU n 
1 288 GLU n 
1 289 ASP n 
1 290 GLU n 
1 291 PHE n 
1 292 THR n 
1 293 PRO n 
1 294 PHE n 
1 295 ASP n 
1 296 VAL n 
1 297 VAL n 
1 298 ARG n 
1 299 GLN n 
1 300 CYS n 
1 301 SER n 
1 302 GLY n 
1 303 VAL n 
1 304 THR n 
1 305 PHE n 
1 306 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   306 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1   1   SER SER A . n 
A 1 2   GLY 2   2   2   GLY GLY A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ARG 4   4   4   ARG ARG A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   MET 6   6   6   MET MET A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  CYS 16  16  16  CYS CYS A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  ILE 21  21  21  ILE ILE A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  ASN 28  28  28  ASN ASN A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  TRP 31  31  31  TRP TRP A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  ASP 34  34  34  ASP ASP A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  CYS 38  38  38  CYS CYS A . n 
A 1 39  PRO 39  39  39  PRO PRO A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  CYS 44  44  44  CYS CYS A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  MET 49  49  49  MET MET A . n 
A 1 50  LEU 50  50  50  LEU LEU A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  ASP 56  56  56  ASP ASP A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  HIS 64  64  64  HIS HIS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  MET 82  82  82  MET MET A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  CYS 85  85  85  CYS CYS A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  ASP 92  92  92  ASP ASP A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  PRO 99  99  99  PRO PRO A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ARG 105 105 105 ARG ARG A . n 
A 1 106 ILE 106 106 106 ILE ILE A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 PHE 134 134 134 PHE PHE A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 CYS 145 145 145 CYS CYS A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 ASP 153 153 153 ASP ASP A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 CYS 156 156 156 CYS CYS A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 CYS 160 160 160 CYS CYS A . n 
A 1 161 TYR 161 161 161 TYR TYR A . n 
A 1 162 MET 162 162 162 MET MET A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 MET 165 165 165 MET MET A . n 
A 1 166 GLU 166 166 166 GLU GLU A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 HIS 172 172 172 HIS HIS A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 GLN 189 189 189 GLN GLN A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 GLN 192 192 192 GLN GLN A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 ILE 200 200 200 ILE ILE A . n 
A 1 201 THR 201 201 201 THR THR A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 TRP 207 207 207 TRP TRP A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ARG 217 217 217 ARG ARG A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ASN 221 221 221 ASN ASN A . n 
A 1 222 ARG 222 222 222 ARG ARG A . n 
A 1 223 PHE 223 223 223 PHE PHE A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 MET 235 235 235 MET MET A . n 
A 1 236 LYS 236 236 236 LYS LYS A . n 
A 1 237 TYR 237 237 237 TYR TYR A . n 
A 1 238 ASN 238 238 238 ASN ASN A . n 
A 1 239 TYR 239 239 239 TYR TYR A . n 
A 1 240 GLU 240 240 240 GLU GLU A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 THR 243 243 243 THR THR A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 ASP 248 248 248 ASP ASP A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 THR 257 257 257 THR THR A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 CYS 265 265 265 CYS CYS A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 LYS 269 269 269 LYS LYS A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 ASN 274 274 274 ASN ASN A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 ASN 277 277 277 ASN ASN A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 SER 284 284 284 SER SER A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 PHE 291 291 291 PHE PHE A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 PRO 293 293 293 PRO PRO A . n 
A 1 294 PHE 294 294 294 PHE PHE A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 VAL 296 296 296 VAL VAL A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLN 299 299 299 GLN GLN A . n 
A 1 300 CYS 300 300 300 CYS CYS A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 GLY 302 302 302 GLY GLY A . n 
A 1 303 VAL 303 303 303 VAL VAL A . n 
A 1 304 THR 304 304 ?   ?   ?   A . n 
A 1 305 PHE 305 305 ?   ?   ?   A . n 
A 1 306 GLN 306 306 ?   ?   ?   A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 HOH 1   401 56  HOH HOH A . 
B 2 HOH 2   402 55  HOH HOH A . 
B 2 HOH 3   403 45  HOH HOH A . 
B 2 HOH 4   404 14  HOH HOH A . 
B 2 HOH 5   405 67  HOH HOH A . 
B 2 HOH 6   406 57  HOH HOH A . 
B 2 HOH 7   407 101 HOH HOH A . 
B 2 HOH 8   408 23  HOH HOH A . 
B 2 HOH 9   409 120 HOH HOH A . 
B 2 HOH 10  410 141 HOH HOH A . 
B 2 HOH 11  411 160 HOH HOH A . 
B 2 HOH 12  412 81  HOH HOH A . 
B 2 HOH 13  413 112 HOH HOH A . 
B 2 HOH 14  414 11  HOH HOH A . 
B 2 HOH 15  415 94  HOH HOH A . 
B 2 HOH 16  416 3   HOH HOH A . 
B 2 HOH 17  417 15  HOH HOH A . 
B 2 HOH 18  418 77  HOH HOH A . 
B 2 HOH 19  419 116 HOH HOH A . 
B 2 HOH 20  420 39  HOH HOH A . 
B 2 HOH 21  421 2   HOH HOH A . 
B 2 HOH 22  422 102 HOH HOH A . 
B 2 HOH 23  423 58  HOH HOH A . 
B 2 HOH 24  424 33  HOH HOH A . 
B 2 HOH 25  425 52  HOH HOH A . 
B 2 HOH 26  426 1   HOH HOH A . 
B 2 HOH 27  427 8   HOH HOH A . 
B 2 HOH 28  428 13  HOH HOH A . 
B 2 HOH 29  429 100 HOH HOH A . 
B 2 HOH 30  430 71  HOH HOH A . 
B 2 HOH 31  431 54  HOH HOH A . 
B 2 HOH 32  432 88  HOH HOH A . 
B 2 HOH 33  433 5   HOH HOH A . 
B 2 HOH 34  434 82  HOH HOH A . 
B 2 HOH 35  435 19  HOH HOH A . 
B 2 HOH 36  436 4   HOH HOH A . 
B 2 HOH 37  437 68  HOH HOH A . 
B 2 HOH 38  438 83  HOH HOH A . 
B 2 HOH 39  439 49  HOH HOH A . 
B 2 HOH 40  440 31  HOH HOH A . 
B 2 HOH 41  441 75  HOH HOH A . 
B 2 HOH 42  442 69  HOH HOH A . 
B 2 HOH 43  443 104 HOH HOH A . 
B 2 HOH 44  444 106 HOH HOH A . 
B 2 HOH 45  445 150 HOH HOH A . 
B 2 HOH 46  446 12  HOH HOH A . 
B 2 HOH 47  447 43  HOH HOH A . 
B 2 HOH 48  448 10  HOH HOH A . 
B 2 HOH 49  449 105 HOH HOH A . 
B 2 HOH 50  450 53  HOH HOH A . 
B 2 HOH 51  451 96  HOH HOH A . 
B 2 HOH 52  452 7   HOH HOH A . 
B 2 HOH 53  453 149 HOH HOH A . 
B 2 HOH 54  454 95  HOH HOH A . 
B 2 HOH 55  455 25  HOH HOH A . 
B 2 HOH 56  456 29  HOH HOH A . 
B 2 HOH 57  457 74  HOH HOH A . 
B 2 HOH 58  458 24  HOH HOH A . 
B 2 HOH 59  459 161 HOH HOH A . 
B 2 HOH 60  460 62  HOH HOH A . 
B 2 HOH 61  461 60  HOH HOH A . 
B 2 HOH 62  462 139 HOH HOH A . 
B 2 HOH 63  463 9   HOH HOH A . 
B 2 HOH 64  464 26  HOH HOH A . 
B 2 HOH 65  465 20  HOH HOH A . 
B 2 HOH 66  466 16  HOH HOH A . 
B 2 HOH 67  467 17  HOH HOH A . 
B 2 HOH 68  468 115 HOH HOH A . 
B 2 HOH 69  469 72  HOH HOH A . 
B 2 HOH 70  470 35  HOH HOH A . 
B 2 HOH 71  471 42  HOH HOH A . 
B 2 HOH 72  472 78  HOH HOH A . 
B 2 HOH 73  473 40  HOH HOH A . 
B 2 HOH 74  474 18  HOH HOH A . 
B 2 HOH 75  475 28  HOH HOH A . 
B 2 HOH 76  476 46  HOH HOH A . 
B 2 HOH 77  477 6   HOH HOH A . 
B 2 HOH 78  478 109 HOH HOH A . 
B 2 HOH 79  479 70  HOH HOH A . 
B 2 HOH 80  480 30  HOH HOH A . 
B 2 HOH 81  481 22  HOH HOH A . 
B 2 HOH 82  482 114 HOH HOH A . 
B 2 HOH 83  483 126 HOH HOH A . 
B 2 HOH 84  484 51  HOH HOH A . 
B 2 HOH 85  485 180 HOH HOH A . 
B 2 HOH 86  486 129 HOH HOH A . 
B 2 HOH 87  487 34  HOH HOH A . 
B 2 HOH 88  488 131 HOH HOH A . 
B 2 HOH 89  489 147 HOH HOH A . 
B 2 HOH 90  490 27  HOH HOH A . 
B 2 HOH 91  491 32  HOH HOH A . 
B 2 HOH 92  492 38  HOH HOH A . 
B 2 HOH 93  493 44  HOH HOH A . 
B 2 HOH 94  494 79  HOH HOH A . 
B 2 HOH 95  495 140 HOH HOH A . 
B 2 HOH 96  496 122 HOH HOH A . 
B 2 HOH 97  497 21  HOH HOH A . 
B 2 HOH 98  498 146 HOH HOH A . 
B 2 HOH 99  499 93  HOH HOH A . 
B 2 HOH 100 500 148 HOH HOH A . 
B 2 HOH 101 501 37  HOH HOH A . 
B 2 HOH 102 502 66  HOH HOH A . 
B 2 HOH 103 503 86  HOH HOH A . 
B 2 HOH 104 504 91  HOH HOH A . 
B 2 HOH 105 505 36  HOH HOH A . 
B 2 HOH 106 506 154 HOH HOH A . 
B 2 HOH 107 507 167 HOH HOH A . 
B 2 HOH 108 508 61  HOH HOH A . 
B 2 HOH 109 509 143 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A GLU 47  ? CG  ? A GLU 47  CG  
2  1 Y 1 A GLU 47  ? CD  ? A GLU 47  CD  
3  1 Y 1 A GLU 47  ? OE1 ? A GLU 47  OE1 
4  1 Y 1 A GLU 47  ? OE2 ? A GLU 47  OE2 
5  1 Y 1 A ARG 60  ? CD  ? A ARG 60  CD  
6  1 Y 1 A ARG 60  ? NE  ? A ARG 60  NE  
7  1 Y 1 A ARG 60  ? CZ  ? A ARG 60  CZ  
8  1 Y 1 A ARG 60  ? NH1 ? A ARG 60  NH1 
9  1 Y 1 A ARG 60  ? NH2 ? A ARG 60  NH2 
10 1 Y 1 A TYR 154 ? CG  ? A TYR 154 CG  
11 1 Y 1 A TYR 154 ? CD1 ? A TYR 154 CD1 
12 1 Y 1 A TYR 154 ? CD2 ? A TYR 154 CD2 
13 1 Y 1 A TYR 154 ? CE1 ? A TYR 154 CE1 
14 1 Y 1 A TYR 154 ? CE2 ? A TYR 154 CE2 
15 1 Y 1 A TYR 154 ? CZ  ? A TYR 154 CZ  
16 1 Y 1 A TYR 154 ? OH  ? A TYR 154 OH  
17 1 Y 1 A ARG 222 ? CG  ? A ARG 222 CG  
18 1 Y 1 A ARG 222 ? CD  ? A ARG 222 CD  
19 1 Y 1 A ARG 222 ? NE  ? A ARG 222 NE  
20 1 Y 1 A ARG 222 ? CZ  ? A ARG 222 CZ  
21 1 Y 1 A ARG 222 ? NH1 ? A ARG 222 NH1 
22 1 Y 1 A ARG 222 ? NH2 ? A ARG 222 NH2 
23 1 Y 1 A MET 235 ? CG  ? A MET 235 CG  
24 1 Y 1 A MET 235 ? SD  ? A MET 235 SD  
25 1 Y 1 A MET 235 ? CE  ? A MET 235 CE  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   102.666 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BNT 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     113.208 
_cell.length_a_esd                 ? 
_cell.length_b                     53.263 
_cell.length_b_esd                 ? 
_cell.length_c                     44.733 
_cell.length_c_esd                 ? 
_cell.volume                       263166.993 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BNT 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y' 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BNT 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             1.94 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          36.74 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              6.0 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M MES monohydrate, 20% w/v Polyethylene glycol monomethyl ether 2,000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            294 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-06-07 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.920105 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSLS-II BEAMLINE 17-ID-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.920105 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID-1 
_diffrn_source.pdbx_synchrotron_site       NSLS-II 
# 
_reflns.B_iso_Wilson_estimate                          29.40 
_reflns.entry_id                                       9BNT 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.83 
_reflns.d_resolution_low                               27.29 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     22613 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.09 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                7.1 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          8.99 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   0.999 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.1224 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.83 
_reflns_shell.d_res_low                                     1.895 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.01 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2201 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               7.4 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.349 
_reflns_shell.pdbx_CC_star                                  0.719 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          96.92 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.758 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               32.53 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9BNT 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.83 
_refine.ls_d_res_low                             27.29 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     22613 
_refine.ls_number_reflns_R_free                  1110 
_refine.ls_number_reflns_R_work                  21503 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.13 
_refine.ls_percent_reflns_R_free                 4.91 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2006 
_refine.ls_R_factor_R_free                       0.2405 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1985 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 27.7236 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2639 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.83 
_refine_hist.d_res_low                        27.29 
_refine_hist.number_atoms_solvent             109 
_refine_hist.number_atoms_total               2425 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2316 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0062  ? 2381 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8586  ? 3242 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0514  ? 369  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0061  ? 423  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 12.5254 ? 848  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.83 1.91  . . 131 2622 97.14 . . . . 0.2941 . . . . . . . . . . . 0.3524 
'X-RAY DIFFRACTION' 1.91 2.01  . . 138 2654 97.52 . . . . 0.2628 . . . . . . . . . . . 0.3474 
'X-RAY DIFFRACTION' 2.01 2.14  . . 148 2643 97.52 . . . . 0.2310 . . . . . . . . . . . 0.2660 
'X-RAY DIFFRACTION' 2.14 2.31  . . 124 2707 98.30 . . . . 0.2152 . . . . . . . . . . . 0.2669 
'X-RAY DIFFRACTION' 2.31 2.54  . . 148 2668 98.36 . . . . 0.2180 . . . . . . . . . . . 0.2770 
'X-RAY DIFFRACTION' 2.54 2.90  . . 129 2721 98.65 . . . . 0.2097 . . . . . . . . . . . 0.2517 
'X-RAY DIFFRACTION' 2.90 3.66  . . 147 2723 98.86 . . . . 0.1913 . . . . . . . . . . . 0.2544 
'X-RAY DIFFRACTION' 3.66 27.29 . . 145 2765 98.71 . . . . 0.1677 . . . . . . . . . . . 0.1849 
# 
_struct.entry_id                     9BNT 
_struct.title                        'Crystal Structure of T21I SARS-CoV-2 Main Protease' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BNT 
_struct_keywords.text            'Hydrolase, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1A_SARS2 
_struct_ref.pdbx_db_accession          P0DTC1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_struct_ref.pdbx_align_begin           3264 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9BNT 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 306 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P0DTC1 
_struct_ref_seq.db_align_beg                  3264 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3569 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       306 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             9BNT 
_struct_ref_seq_dif.mon_id                       ILE 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      21 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   P0DTC1 
_struct_ref_seq_dif.db_mon_id                    THR 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          3284 
_struct_ref_seq_dif.details                      'engineered mutation' 
_struct_ref_seq_dif.pdbx_auth_seq_num            21 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2790  ? 
1 MORE         -14   ? 
1 'SSA (A^2)'  24790 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000 0.0000000000 0.0000000000  0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000  
2 'crystal symmetry operation' 2_556 -x,y,-z+1 -1.0000000000 0.0000000000 0.0000000000 -9.8084828706 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 43.6444149093 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 10  ? GLY A 15  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 41  ? CYS A 44  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 GLU A 47  ? ASN A 51  ? GLU A 47  ASN A 51  5 ? 5  
HELX_P HELX_P4  AA4 ASN A 53  ? ARG A 60  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P5  AA5 LYS A 61  ? HIS A 64  ? LYS A 61  HIS A 64  5 ? 4  
HELX_P HELX_P6  AA6 ILE A 200 ? ASN A 214 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P7  AA7 THR A 226 ? TYR A 237 ? THR A 226 TYR A 237 1 ? 12 
HELX_P HELX_P8  AA8 THR A 243 ? LEU A 250 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P9  AA9 LEU A 250 ? GLY A 258 ? LEU A 250 GLY A 258 1 ? 9  
HELX_P HELX_P10 AB1 ALA A 260 ? GLY A 275 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P11 AB2 THR A 292 ? GLY A 302 ? THR A 292 GLY A 302 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 73  ? LEU A 75  ? VAL A 73  LEU A 75  
AA1 2 PHE A 66  ? ALA A 70  ? PHE A 66  ALA A 70  
AA1 3 MET A 17  ? CYS A 22  ? MET A 17  CYS A 22  
AA1 4 THR A 25  ? LEU A 32  ? THR A 25  LEU A 32  
AA1 5 VAL A 35  ? PRO A 39  ? VAL A 35  PRO A 39  
AA1 6 VAL A 86  ? VAL A 91  ? VAL A 86  VAL A 91  
AA1 7 VAL A 77  ? GLN A 83  ? VAL A 77  GLN A 83  
AA2 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA2 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA2 3 VAL A 148 ? ASP A 153 ? VAL A 148 ASP A 153 
AA2 4 THR A 111 ? TYR A 118 ? THR A 111 TYR A 118 
AA2 5 SER A 121 ? ALA A 129 ? SER A 121 ALA A 129 
AA3 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA3 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA3 3 HIS A 172 ? THR A 175 ? HIS A 172 THR A 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 73  ? O VAL A 73  N ALA A 70  ? N ALA A 70  
AA1 2 3 O LEU A 67  ? O LEU A 67  N ILE A 21  ? N ILE A 21  
AA1 3 4 N VAL A 20  ? N VAL A 20  O LEU A 27  ? O LEU A 27  
AA1 4 5 N LEU A 30  ? N LEU A 30  O TYR A 37  ? O TYR A 37  
AA1 5 6 N VAL A 36  ? N VAL A 36  O LEU A 89  ? O LEU A 89  
AA1 6 7 O LYS A 90  ? O LYS A 90  N ILE A 78  ? N ILE A 78  
AA2 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA2 2 3 O SER A 158 ? O SER A 158 N ASN A 151 ? N ASN A 151 
AA2 3 4 O PHE A 150 ? O PHE A 150 N SER A 113 ? N SER A 113 
AA2 4 5 N ALA A 116 ? N ALA A 116 O SER A 123 ? O SER A 123 
AA3 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA3 2 3 N MET A 165 ? N MET A 165 O ALA A 173 ? O ALA A 173 
# 
_pdbx_entry_details.entry_id                   9BNT 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 55.27   -131.35 
2 1 ASN A 51  ? ? -158.84 70.99   
3 1 ASN A 84  ? ? 57.16   -118.53 
4 1 TYR A 154 ? ? 52.58   -92.30  
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    A 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     494 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   B 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 -x,y,-z         
3 x+1/2,y+1/2,z   
4 -x+1/2,y+1/2,-z 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A THR 304 ? A THR 304 
2 1 Y 1 A PHE 305 ? A PHE 305 
3 1 Y 1 A GLN 306 ? A GLN 306 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' 'P30 GM133893' 1 
'Department of Energy (DOE, United States)'                                                'United States' KP1607011      2 
'Other government'                                                                         'United States' DE-SC0012704   3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6Y2E 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'C 1 2 1' 
_space_group.name_Hall        'C 2y' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9BNT 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.008833 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.001985 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.018775 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.022912 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . SER A 1 1   ? -2.27233  -22.06815 38.86774  1.000 34.54490 ? 1   SER A N   1 
ATOM   2    C CA  . SER A 1 1   ? -2.86880  -20.91650 38.21461  1.000 32.26633 ? 1   SER A CA  1 
ATOM   3    C C   . SER A 1 1   ? -2.36307  -20.72627 36.78656  1.000 41.10857 ? 1   SER A C   1 
ATOM   4    O O   . SER A 1 1   ? -1.60209  -21.54567 36.25957  1.000 35.90924 ? 1   SER A O   1 
ATOM   5    C CB  . SER A 1 1   ? -2.60519  -19.65081 39.03149  1.000 53.16956 ? 1   SER A CB  1 
ATOM   6    O OG  . SER A 1 1   ? -1.21439  -19.40091 39.13780  1.000 50.23597 ? 1   SER A OG  1 
ATOM   7    N N   . GLY A 1 2   ? -2.76313  -19.61927 36.18643  1.000 36.43678 ? 2   GLY A N   1 
ATOM   8    C CA  . GLY A 1 2   ? -2.62424  -19.40219 34.75903  1.000 35.93411 ? 2   GLY A CA  1 
ATOM   9    C C   . GLY A 1 2   ? -3.83087  -19.92321 34.00525  1.000 34.03878 ? 2   GLY A C   1 
ATOM   10   O O   . GLY A 1 2   ? -4.52940  -20.84229 34.44121  1.000 36.49781 ? 2   GLY A O   1 
ATOM   11   N N   . PHE A 1 3   ? -4.07621  -19.32939 32.83697  1.000 32.06728 ? 3   PHE A N   1 
ATOM   12   C CA  . PHE A 1 3   ? -5.27861  -19.63471 32.07158  1.000 36.30485 ? 3   PHE A CA  1 
ATOM   13   C C   . PHE A 1 3   ? -4.94547  -19.66172 30.58927  1.000 28.67361 ? 3   PHE A C   1 
ATOM   14   O O   . PHE A 1 3   ? -4.38231  -18.70338 30.05684  1.000 41.54152 ? 3   PHE A O   1 
ATOM   15   C CB  . PHE A 1 3   ? -6.39814  -18.62239 32.36058  1.000 35.26026 ? 3   PHE A CB  1 
ATOM   16   C CG  . PHE A 1 3   ? -7.77025  -19.16628 32.10440  1.000 26.67531 ? 3   PHE A CG  1 
ATOM   17   C CD1 . PHE A 1 3   ? -8.36954  -20.01375 33.02270  1.000 32.37002 ? 3   PHE A CD1 1 
ATOM   18   C CD2 . PHE A 1 3   ? -8.45071  -18.85017 30.93931  1.000 32.75233 ? 3   PHE A CD2 1 
ATOM   19   C CE1 . PHE A 1 3   ? -9.61845  -20.53375 32.79687  1.000 31.46142 ? 3   PHE A CE1 1 
ATOM   20   C CE2 . PHE A 1 3   ? -9.72661  -19.36036 30.71279  1.000 31.14111 ? 3   PHE A CE2 1 
ATOM   21   C CZ  . PHE A 1 3   ? -10.30051 -20.20676 31.63204  1.000 32.08293 ? 3   PHE A CZ  1 
ATOM   22   N N   . ARG A 1 4   ? -5.32136  -20.75419 29.93175  1.000 32.43579 ? 4   ARG A N   1 
ATOM   23   C CA  . ARG A 1 4   ? -4.90553  -21.07850 28.57318  1.000 28.08353 ? 4   ARG A CA  1 
ATOM   24   C C   . ARG A 1 4   ? -6.10095  -21.55016 27.75983  1.000 25.07141 ? 4   ARG A C   1 
ATOM   25   O O   . ARG A 1 4   ? -6.97215  -22.25034 28.27991  1.000 28.93198 ? 4   ARG A O   1 
ATOM   26   C CB  . ARG A 1 4   ? -3.83838  -22.18666 28.59681  1.000 29.85774 ? 4   ARG A CB  1 
ATOM   27   C CG  . ARG A 1 4   ? -2.42056  -21.69772 28.82250  1.000 29.36036 ? 4   ARG A CG  1 
ATOM   28   C CD  . ARG A 1 4   ? -1.86080  -21.17173 27.49416  1.000 36.63519 ? 4   ARG A CD  1 
ATOM   29   N NE  . ARG A 1 4   ? -0.46868  -20.74624 27.57632  1.000 32.91043 ? 4   ARG A NE  1 
ATOM   30   C CZ  . ARG A 1 4   ? 0.19501   -20.20859 26.56297  1.000 44.31114 ? 4   ARG A CZ  1 
ATOM   31   N NH1 . ARG A 1 4   ? -0.37041  -20.05232 25.37650  1.000 42.76231 ? 4   ARG A NH1 1 
ATOM   32   N NH2 . ARG A 1 4   ? 1.45236   -19.81066 26.74494  1.000 37.66185 ? 4   ARG A NH2 1 
ATOM   33   N N   . LYS A 1 5   ? -6.13468  -21.19734 26.47854  1.000 24.67342 ? 5   LYS A N   1 
ATOM   34   C CA  . LYS A 1 5   ? -7.11201  -21.82512 25.60249  1.000 26.85677 ? 5   LYS A CA  1 
ATOM   35   C C   . LYS A 1 5   ? -6.71437  -23.28501 25.41560  1.000 35.77686 ? 5   LYS A C   1 
ATOM   36   O O   . LYS A 1 5   ? -5.68559  -23.59973 24.80176  1.000 31.94617 ? 5   LYS A O   1 
ATOM   37   C CB  . LYS A 1 5   ? -7.22685  -21.08940 24.27667  1.000 25.70025 ? 5   LYS A CB  1 
ATOM   38   C CG  . LYS A 1 5   ? -8.49157  -21.47557 23.53150  1.000 30.54311 ? 5   LYS A CG  1 
ATOM   39   C CD  . LYS A 1 5   ? -8.82318  -20.46677 22.46328  1.000 38.11590 ? 5   LYS A CD  1 
ATOM   40   C CE  . LYS A 1 5   ? -9.22516  -19.15198 23.07918  1.000 35.35354 ? 5   LYS A CE  1 
ATOM   41   N NZ  . LYS A 1 5   ? -9.48521  -18.15740 22.01882  1.000 47.63219 ? 5   LYS A NZ  1 
ATOM   42   N N   . MET A 1 6   ? -7.52161  -24.17424 25.97529  1.000 28.83161 ? 6   MET A N   1 
ATOM   43   C CA  . MET A 1 6   ? -7.17181  -25.57375 26.13874  1.000 25.68249 ? 6   MET A CA  1 
ATOM   44   C C   . MET A 1 6   ? -8.15407  -26.43682 25.37057  1.000 24.07556 ? 6   MET A C   1 
ATOM   45   O O   . MET A 1 6   ? -9.37213  -26.28035 25.52680  1.000 27.55706 ? 6   MET A O   1 
ATOM   46   C CB  . MET A 1 6   ? -7.21154  -25.94224 27.61663  1.000 29.57786 ? 6   MET A CB  1 
ATOM   47   C CG  . MET A 1 6   ? -6.42672  -27.17102 27.96014  1.000 34.58115 ? 6   MET A CG  1 
ATOM   48   S SD  . MET A 1 6   ? -6.28558  -27.31164 29.73919  1.000 47.84505 ? 6   MET A SD  1 
ATOM   49   C CE  . MET A 1 6   ? -5.62381  -25.71271 30.13743  1.000 35.13266 ? 6   MET A CE  1 
ATOM   50   N N   . ALA A 1 7   ? -7.63484  -27.36079 24.57064  1.000 26.77051 ? 7   ALA A N   1 
ATOM   51   C CA  . ALA A 1 7   ? -8.50310  -28.32607 23.90947  1.000 26.34067 ? 7   ALA A CA  1 
ATOM   52   C C   . ALA A 1 7   ? -8.62175  -29.59689 24.74437  1.000 29.13920 ? 7   ALA A C   1 
ATOM   53   O O   . ALA A 1 7   ? -7.85725  -29.82484 25.68092  1.000 30.41240 ? 7   ALA A O   1 
ATOM   54   C CB  . ALA A 1 7   ? -7.97890  -28.66183 22.51629  1.000 27.02142 ? 7   ALA A CB  1 
ATOM   55   N N   . PHE A 1 8   ? -9.61216  -30.42034 24.40820  1.000 25.83064 ? 8   PHE A N   1 
ATOM   56   C CA  . PHE A 1 8   ? -9.71291  -31.72259 25.03516  1.000 29.70716 ? 8   PHE A CA  1 
ATOM   57   C C   . PHE A 1 8   ? -8.61360  -32.63959 24.50444  1.000 26.02784 ? 8   PHE A C   1 
ATOM   58   O O   . PHE A 1 8   ? -8.16613  -32.49291 23.36199  1.000 23.32173 ? 8   PHE A O   1 
ATOM   59   C CB  . PHE A 1 8   ? -11.08359 -32.34017 24.77399  1.000 23.13424 ? 8   PHE A CB  1 
ATOM   60   C CG  . PHE A 1 8   ? -12.20706 -31.60603 25.43637  1.000 29.71012 ? 8   PHE A CG  1 
ATOM   61   C CD1 . PHE A 1 8   ? -12.50553 -31.82807 26.77355  1.000 33.35086 ? 8   PHE A CD1 1 
ATOM   62   C CD2 . PHE A 1 8   ? -12.97376 -30.69717 24.72619  1.000 28.16226 ? 8   PHE A CD2 1 
ATOM   63   C CE1 . PHE A 1 8   ? -13.54217 -31.14978 27.39167  1.000 37.00099 ? 8   PHE A CE1 1 
ATOM   64   C CE2 . PHE A 1 8   ? -14.01345 -30.01665 25.33795  1.000 32.56271 ? 8   PHE A CE2 1 
ATOM   65   C CZ  . PHE A 1 8   ? -14.29791 -30.24055 26.66948  1.000 34.04632 ? 8   PHE A CZ  1 
ATOM   66   N N   . PRO A 1 9   ? -8.15136  -33.58698 25.31616  1.000 27.82880 ? 9   PRO A N   1 
ATOM   67   C CA  . PRO A 1 9   ? -7.22707  -34.60880 24.79825  1.000 32.72564 ? 9   PRO A CA  1 
ATOM   68   C C   . PRO A 1 9   ? -7.83766  -35.27887 23.57448  1.000 22.73819 ? 9   PRO A C   1 
ATOM   69   O O   . PRO A 1 9   ? -9.03527  -35.56010 23.54024  1.000 35.16884 ? 9   PRO A O   1 
ATOM   70   C CB  . PRO A 1 9   ? -7.08110  -35.58095 25.97275  1.000 26.10904 ? 9   PRO A CB  1 
ATOM   71   C CG  . PRO A 1 9   ? -7.41528  -34.74366 27.18993  1.000 35.67786 ? 9   PRO A CG  1 
ATOM   72   C CD  . PRO A 1 9   ? -8.49191  -33.80465 26.73091  1.000 29.66811 ? 9   PRO A CD  1 
ATOM   73   N N   . SER A 1 10  ? -7.03062  -35.47632 22.54162  1.000 28.79021 ? 10  SER A N   1 
ATOM   74   C CA  . SER A 1 10  ? -7.59283  -35.85354 21.25296  1.000 28.37196 ? 10  SER A CA  1 
ATOM   75   C C   . SER A 1 10  ? -7.55579  -37.35190 20.98217  1.000 27.47023 ? 10  SER A C   1 
ATOM   76   O O   . SER A 1 10  ? -8.14329  -37.78994 19.98937  1.000 28.46127 ? 10  SER A O   1 
ATOM   77   C CB  . SER A 1 10  ? -6.88438  -35.09882 20.12113  1.000 29.50360 ? 10  SER A CB  1 
ATOM   78   O OG  . SER A 1 10  ? -5.53980  -35.48948 19.98852  1.000 30.26114 ? 10  SER A OG  1 
ATOM   79   N N   . GLY A 1 11  ? -6.94977  -38.14950 21.87183  1.000 27.46923 ? 11  GLY A N   1 
ATOM   80   C CA  . GLY A 1 11  ? -6.66278  -39.53787 21.54390  1.000 24.08407 ? 11  GLY A CA  1 
ATOM   81   C C   . GLY A 1 11  ? -7.89446  -40.35610 21.21153  1.000 23.87517 ? 11  GLY A C   1 
ATOM   82   O O   . GLY A 1 11  ? -7.85757  -41.22107 20.33213  1.000 31.59726 ? 11  GLY A O   1 
ATOM   83   N N   . LYS A 1 12  ? -8.99422  -40.12014 21.92267  1.000 23.25618 ? 12  LYS A N   1 
ATOM   84   C CA  . LYS A 1 12  ? -10.19889 -40.89106 21.64844  1.000 28.48885 ? 12  LYS A CA  1 
ATOM   85   C C   . LYS A 1 12  ? -10.69894 -40.65362 20.22615  1.000 31.52434 ? 12  LYS A C   1 
ATOM   86   O O   . LYS A 1 12  ? -11.26020 -41.56223 19.60518  1.000 32.67772 ? 12  LYS A O   1 
ATOM   87   C CB  . LYS A 1 12  ? -11.27891 -40.54181 22.67002  1.000 26.85910 ? 12  LYS A CB  1 
ATOM   88   C CG  . LYS A 1 12  ? -11.11961 -41.24889 24.01039  1.000 30.47114 ? 12  LYS A CG  1 
ATOM   89   C CD  . LYS A 1 12  ? -12.00851 -40.60557 25.07222  1.000 34.31725 ? 12  LYS A CD  1 
ATOM   90   C CE  . LYS A 1 12  ? -12.22256 -41.54511 26.24534  1.000 46.83828 ? 12  LYS A CE  1 
ATOM   91   N NZ  . LYS A 1 12  ? -11.09804 -42.51230 26.32644  1.000 60.33315 ? 12  LYS A NZ  1 
ATOM   92   N N   . VAL A 1 13  ? -10.49848 -39.44989 19.69659  1.000 29.03147 ? 13  VAL A N   1 
ATOM   93   C CA  . VAL A 1 13  ? -10.93482 -39.13283 18.33999  1.000 23.22361 ? 13  VAL A CA  1 
ATOM   94   C C   . VAL A 1 13  ? -9.88875  -39.51217 17.30113  1.000 23.80013 ? 13  VAL A C   1 
ATOM   95   O O   . VAL A 1 13  ? -10.24256 -39.86959 16.17438  1.000 25.57334 ? 13  VAL A O   1 
ATOM   96   C CB  . VAL A 1 13  ? -11.30875 -37.64382 18.23679  1.000 23.22984 ? 13  VAL A CB  1 
ATOM   97   C CG1 . VAL A 1 13  ? -11.79133 -37.29954 16.82963  1.000 23.55898 ? 13  VAL A CG1 1 
ATOM   98   C CG2 . VAL A 1 13  ? -12.37202 -37.30099 19.26551  1.000 24.11646 ? 13  VAL A CG2 1 
ATOM   99   N N   . GLU A 1 14  ? -8.60056  -39.45243 17.64521  1.000 22.62486 ? 14  GLU A N   1 
ATOM   100  C CA  . GLU A 1 14  ? -7.59391  -39.92760 16.70236  1.000 25.46686 ? 14  GLU A CA  1 
ATOM   101  C C   . GLU A 1 14  ? -7.88562  -41.35788 16.28232  1.000 31.09900 ? 14  GLU A C   1 
ATOM   102  O O   . GLU A 1 14  ? -7.81443  -41.69062 15.09451  1.000 28.03305 ? 14  GLU A O   1 
ATOM   103  C CB  . GLU A 1 14  ? -6.18904  -39.84051 17.30213  1.000 28.94279 ? 14  GLU A CB  1 
ATOM   104  C CG  . GLU A 1 14  ? -5.75615  -38.43215 17.70533  1.000 26.66694 ? 14  GLU A CG  1 
ATOM   105  C CD  . GLU A 1 14  ? -4.48577  -38.45481 18.53815  1.000 24.99996 ? 14  GLU A CD  1 
ATOM   106  O OE1 . GLU A 1 14  ? -3.57925  -39.23236 18.19358  1.000 35.10452 ? 14  GLU A OE1 1 
ATOM   107  O OE2 . GLU A 1 14  ? -4.39214  -37.69721 19.53329  1.000 29.44553 ? 14  GLU A OE2 1 
ATOM   108  N N   . GLY A 1 15  ? -8.25861  -42.20577 17.23786  1.000 25.26962 ? 15  GLY A N   1 
ATOM   109  C CA  . GLY A 1 15  ? -8.55167  -43.59284 16.93806  1.000 32.50201 ? 15  GLY A CA  1 
ATOM   110  C C   . GLY A 1 15  ? -9.73478  -43.80332 16.01397  1.000 30.47539 ? 15  GLY A C   1 
ATOM   111  O O   . GLY A 1 15  ? -10.01221 -44.93419 15.61945  1.000 32.24800 ? 15  GLY A O   1 
ATOM   112  N N   . CYS A 1 16  ? -10.45541 -42.73622 15.66522  1.000 25.48591 ? 16  CYS A N   1 
ATOM   113  C CA  . CYS A 1 16  ? -11.62465 -42.85977 14.80793  1.000 26.74633 ? 16  CYS A CA  1 
ATOM   114  C C   . CYS A 1 16  ? -11.44681 -42.24315 13.43314  1.000 25.87325 ? 16  CYS A C   1 
ATOM   115  O O   . CYS A 1 16  ? -12.34882 -42.37422 12.60147  1.000 25.94073 ? 16  CYS A O   1 
ATOM   116  C CB  . CYS A 1 16  ? -12.85287 -42.21650 15.46210  1.000 21.00616 ? 16  CYS A CB  1 
ATOM   117  S SG  . CYS A 1 16  ? -13.25367 -42.84754 17.10983  1.000 31.20378 ? 16  CYS A SG  1 
ATOM   118  N N   . MET A 1 17  ? -10.33440 -41.56572 13.17237  1.000 29.13005 ? 17  MET A N   1 
ATOM   119  C CA  . MET A 1 17  ? -10.17315 -40.86861 11.91179  1.000 23.39448 ? 17  MET A CA  1 
ATOM   120  C C   . MET A 1 17  ? -9.70222  -41.83759 10.83918  1.000 29.99701 ? 17  MET A C   1 
ATOM   121  O O   . MET A 1 17  ? -8.78032  -42.63292 11.06855  1.000 29.51462 ? 17  MET A O   1 
ATOM   122  C CB  . MET A 1 17  ? -9.17861  -39.71155 12.04932  1.000 24.14038 ? 17  MET A CB  1 
ATOM   123  C CG  . MET A 1 17  ? -9.58793  -38.63169 13.03930  1.000 28.35247 ? 17  MET A CG  1 
ATOM   124  S SD  . MET A 1 17  ? -11.25014 -38.00514 12.80423  1.000 27.02627 ? 17  MET A SD  1 
ATOM   125  C CE  . MET A 1 17  ? -11.20411 -37.45337 11.10488  1.000 25.57911 ? 17  MET A CE  1 
ATOM   126  N N   . VAL A 1 18  ? -10.33423 -41.76584 9.66518   1.000 24.47567 ? 18  VAL A N   1 
ATOM   127  C CA  . VAL A 1 18  ? -9.96470  -42.58474 8.51858   1.000 27.24876 ? 18  VAL A CA  1 
ATOM   128  C C   . VAL A 1 18  ? -9.86646  -41.71324 7.27156   1.000 25.52057 ? 18  VAL A C   1 
ATOM   129  O O   . VAL A 1 18  ? -10.37176 -40.59219 7.21616   1.000 26.14861 ? 18  VAL A O   1 
ATOM   130  C CB  . VAL A 1 18  ? -10.95909 -43.73784 8.27515   1.000 26.79321 ? 18  VAL A CB  1 
ATOM   131  C CG1 . VAL A 1 18  ? -10.99870 -44.67466 9.46211   1.000 29.83096 ? 18  VAL A CG1 1 
ATOM   132  C CG2 . VAL A 1 18  ? -12.34134 -43.18317 7.98020   1.000 29.23053 ? 18  VAL A CG2 1 
ATOM   133  N N   . GLN A 1 19  ? -9.21415  -42.25704 6.25438   1.000 22.42217 ? 19  GLN A N   1 
ATOM   134  C CA  . GLN A 1 19  ? -9.15598  -41.62644 4.95167   1.000 27.22583 ? 19  GLN A CA  1 
ATOM   135  C C   . GLN A 1 19  ? -10.28425 -42.16861 4.08802   1.000 28.03113 ? 19  GLN A C   1 
ATOM   136  O O   . GLN A 1 19  ? -10.51440 -43.38340 4.05118   1.000 23.89735 ? 19  GLN A O   1 
ATOM   137  C CB  . GLN A 1 19  ? -7.80337  -41.91412 4.30750   1.000 30.60584 ? 19  GLN A CB  1 
ATOM   138  C CG  . GLN A 1 19  ? -7.59981  -41.31607 2.95233   1.000 28.64588 ? 19  GLN A CG  1 
ATOM   139  C CD  . GLN A 1 19  ? -6.48483  -42.02391 2.21192   1.000 32.55133 ? 19  GLN A CD  1 
ATOM   140  O OE1 . GLN A 1 19  ? -6.53344  -43.24084 2.02799   1.000 36.53134 ? 19  GLN A OE1 1 
ATOM   141  N NE2 . GLN A 1 19  ? -5.46284  -41.27923 1.81596   1.000 32.68320 ? 19  GLN A NE2 1 
ATOM   142  N N   . VAL A 1 20  ? -10.98521 -41.27984 3.39013   1.000 26.58727 ? 20  VAL A N   1 
ATOM   143  C CA  . VAL A 1 20  ? -12.03400 -41.69577 2.46376   1.000 24.92592 ? 20  VAL A CA  1 
ATOM   144  C C   . VAL A 1 20  ? -11.68926 -41.16471 1.08549   1.000 29.89854 ? 20  VAL A C   1 
ATOM   145  O O   . VAL A 1 20  ? -11.47674 -39.95696 0.91276   1.000 28.70219 ? 20  VAL A O   1 
ATOM   146  C CB  . VAL A 1 20  ? -13.42813 -41.21753 2.89282   1.000 27.87397 ? 20  VAL A CB  1 
ATOM   147  C CG1 . VAL A 1 20  ? -14.44782 -41.61727 1.82461   1.000 23.93684 ? 20  VAL A CG1 1 
ATOM   148  C CG2 . VAL A 1 20  ? -13.79779 -41.82004 4.23150   1.000 25.55881 ? 20  VAL A CG2 1 
ATOM   149  N N   . ILE A 1 21  ? -11.64660 -42.06481 0.10625   1.000 26.05634 ? 21  ILE A N   1 
ATOM   150  C CA  . ILE A 1 21  ? -11.37190 -41.71779 -1.27812  1.000 24.38786 ? 21  ILE A CA  1 
ATOM   151  C C   . ILE A 1 21  ? -12.55359 -42.16210 -2.12258  1.000 24.12185 ? 21  ILE A C   1 
ATOM   152  O O   . ILE A 1 21  ? -12.96075 -43.32713 -2.07183  1.000 31.10418 ? 21  ILE A O   1 
ATOM   153  C CB  . ILE A 1 21  ? -10.06852 -42.36619 -1.78696  1.000 31.82185 ? 21  ILE A CB  1 
ATOM   154  C CG1 . ILE A 1 21  ? -8.88907  -41.98812 -0.88649  1.000 33.80099 ? 21  ILE A CG1 1 
ATOM   155  C CG2 . ILE A 1 21  ? -9.79169  -41.92562 -3.21070  1.000 30.19512 ? 21  ILE A CG2 1 
ATOM   156  C CD1 . ILE A 1 21  ? -7.55965  -42.55193 -1.35894  1.000 31.04859 ? 21  ILE A CD1 1 
ATOM   157  N N   . CYS A 1 22  ? -13.08508 -41.24411 -2.90969  1.000 27.04700 ? 22  CYS A N   1 
ATOM   158  C CA  . CYS A 1 22  ? -14.09500 -41.56208 -3.90808  1.000 29.40547 ? 22  CYS A CA  1 
ATOM   159  C C   . CYS A 1 22  ? -13.59905 -40.97079 -5.21775  1.000 32.47088 ? 22  CYS A C   1 
ATOM   160  O O   . CYS A 1 22  ? -13.48230 -39.74577 -5.34535  1.000 32.12957 ? 22  CYS A O   1 
ATOM   161  C CB  . CYS A 1 22  ? -15.46042 -41.00223 -3.51113  1.000 27.56430 ? 22  CYS A CB  1 
ATOM   162  S SG  . CYS A 1 22  ? -16.82314 -41.48227 -4.60026  1.000 36.19756 ? 22  CYS A SG  1 
ATOM   163  N N   . GLY A 1 23  ? -13.26523 -41.83364 -6.16550  1.000 37.14724 ? 23  GLY A N   1 
ATOM   164  C CA  . GLY A 1 23  ? -12.65859 -41.35158 -7.39449  1.000 38.28567 ? 23  GLY A CA  1 
ATOM   165  C C   . GLY A 1 23  ? -11.43167 -40.50730 -7.09384  1.000 34.24676 ? 23  GLY A C   1 
ATOM   166  O O   . GLY A 1 23  ? -10.47354 -40.96600 -6.46394  1.000 39.52142 ? 23  GLY A O   1 
ATOM   167  N N   . THR A 1 24  ? -11.46595 -39.24683 -7.50859  1.000 34.90942 ? 24  THR A N   1 
ATOM   168  C CA  . THR A 1 24  ? -10.30949 -38.35999 -7.43335  1.000 38.59903 ? 24  THR A CA  1 
ATOM   169  C C   . THR A 1 24  ? -10.26815 -37.51139 -6.16882  1.000 35.92549 ? 24  THR A C   1 
ATOM   170  O O   . THR A 1 24  ? -9.34739  -36.70426 -6.01879  1.000 34.73837 ? 24  THR A O   1 
ATOM   171  C CB  . THR A 1 24  ? -10.28316 -37.42920 -8.65504  1.000 42.91327 ? 24  THR A CB  1 
ATOM   172  O OG1 . THR A 1 24  ? -9.10664  -36.61476 -8.61548  1.000 58.92226 ? 24  THR A OG1 1 
ATOM   173  C CG2 . THR A 1 24  ? -11.50301 -36.52319 -8.66446  1.000 45.74251 ? 24  THR A CG2 1 
ATOM   174  N N   . THR A 1 25  ? -11.22944 -37.66170 -5.26378  1.000 34.85774 ? 25  THR A N   1 
ATOM   175  C CA  . THR A 1 25  ? -11.38690 -36.77081 -4.11881  1.000 28.55456 ? 25  THR A CA  1 
ATOM   176  C C   . THR A 1 25  ? -11.00580 -37.51694 -2.84942  1.000 24.16079 ? 25  THR A C   1 
ATOM   177  O O   . THR A 1 25  ? -11.46740 -38.63924 -2.63274  1.000 29.59633 ? 25  THR A O   1 
ATOM   178  C CB  . THR A 1 25  ? -12.83066 -36.26668 -4.04825  1.000 32.09863 ? 25  THR A CB  1 
ATOM   179  O OG1 . THR A 1 25  ? -13.15050 -35.56714 -5.26540  1.000 29.44432 ? 25  THR A OG1 1 
ATOM   180  C CG2 . THR A 1 25  ? -13.05469 -35.35034 -2.84480  1.000 30.33604 ? 25  THR A CG2 1 
ATOM   181  N N   . THR A 1 26  ? -10.14368 -36.91774 -2.02946  1.000 26.32771 ? 26  THR A N   1 
ATOM   182  C CA  . THR A 1 26  ? -9.73337  -37.51463 -0.76102  1.000 25.25711 ? 26  THR A CA  1 
ATOM   183  C C   . THR A 1 26  ? -10.08465 -36.57759 0.38740   1.000 24.87230 ? 26  THR A C   1 
ATOM   184  O O   . THR A 1 26  ? -9.64719  -35.42375 0.40491   1.000 28.46334 ? 26  THR A O   1 
ATOM   185  C CB  . THR A 1 26  ? -8.23496  -37.83008 -0.74197  1.000 27.91865 ? 26  THR A CB  1 
ATOM   186  O OG1 . THR A 1 26  ? -7.95475  -38.82518 -1.73324  1.000 36.83133 ? 26  THR A OG1 1 
ATOM   187  C CG2 . THR A 1 26  ? -7.83548  -38.38387 0.61463   1.000 30.78243 ? 26  THR A CG2 1 
ATOM   188  N N   . LEU A 1 27  ? -10.85379 -37.07165 1.35520   1.000 25.75219 ? 27  LEU A N   1 
ATOM   189  C CA  . LEU A 1 27  ? -11.04353 -36.29791 2.57782   1.000 24.18894 ? 27  LEU A CA  1 
ATOM   190  C C   . LEU A 1 27  ? -11.08781 -37.26109 3.75792   1.000 29.22215 ? 27  LEU A C   1 
ATOM   191  O O   . LEU A 1 27  ? -10.77107 -38.44959 3.62584   1.000 26.34504 ? 27  LEU A O   1 
ATOM   192  C CB  . LEU A 1 27  ? -12.28078 -35.39935 2.46196   1.000 24.82863 ? 27  LEU A CB  1 
ATOM   193  C CG  . LEU A 1 27  ? -13.52764 -35.94358 1.78733   1.000 23.59915 ? 27  LEU A CG  1 
ATOM   194  C CD1 . LEU A 1 27  ? -14.04219 -37.16568 2.53768   1.000 23.65546 ? 27  LEU A CD1 1 
ATOM   195  C CD2 . LEU A 1 27  ? -14.60230 -34.86774 1.67769   1.000 22.02938 ? 27  LEU A CD2 1 
ATOM   196  N N   . ASN A 1 28  ? -11.49867 -36.74192 4.91593   1.000 22.73187 ? 28  ASN A N   1 
ATOM   197  C CA  . ASN A 1 28  ? -11.45288 -37.47826 6.16971   1.000 23.82596 ? 28  ASN A CA  1 
ATOM   198  C C   . ASN A 1 28  ? -12.82776 -38.01957 6.53035   1.000 28.31761 ? 28  ASN A C   1 
ATOM   199  O O   . ASN A 1 28  ? -13.85627 -37.38943 6.26922   1.000 23.58984 ? 28  ASN A O   1 
ATOM   200  C CB  . ASN A 1 28  ? -10.94928 -36.59799 7.31655   1.000 26.49979 ? 28  ASN A CB  1 
ATOM   201  C CG  . ASN A 1 28  ? -9.59854  -35.98563 7.02147   1.000 26.53531 ? 28  ASN A CG  1 
ATOM   202  O OD1 . ASN A 1 28  ? -8.57955  -36.64997 7.13479   1.000 26.37198 ? 28  ASN A OD1 1 
ATOM   203  N ND2 . ASN A 1 28  ? -9.58838  -34.71402 6.64144   1.000 27.41166 ? 28  ASN A ND2 1 
ATOM   204  N N   . GLY A 1 29  ? -12.82958 -39.20421 7.12552   1.000 24.18735 ? 29  GLY A N   1 
ATOM   205  C CA  . GLY A 1 29  ? -14.05848 -39.77292 7.62817   1.000 21.91651 ? 29  GLY A CA  1 
ATOM   206  C C   . GLY A 1 29  ? -13.93193 -40.06927 9.10432   1.000 24.39275 ? 29  GLY A C   1 
ATOM   207  O O   . GLY A 1 29  ? -12.82229 -40.12179 9.64473   1.000 24.70735 ? 29  GLY A O   1 
ATOM   208  N N   . LEU A 1 30  ? -15.06403 -40.29718 9.75231   1.000 27.81083 ? 30  LEU A N   1 
ATOM   209  C CA  . LEU A 1 30  ? -15.11882 -40.62557 11.16673  1.000 29.31019 ? 30  LEU A CA  1 
ATOM   210  C C   . LEU A 1 30  ? -15.73529 -42.01154 11.30361  1.000 26.46444 ? 30  LEU A C   1 
ATOM   211  O O   . LEU A 1 30  ? -16.89679 -42.22054 10.92598  1.000 26.31562 ? 30  LEU A O   1 
ATOM   212  C CB  . LEU A 1 30  ? -15.92793 -39.58582 11.93419  1.000 21.66378 ? 30  LEU A CB  1 
ATOM   213  C CG  . LEU A 1 30  ? -16.03875 -39.79889 13.44932  1.000 32.35217 ? 30  LEU A CG  1 
ATOM   214  C CD1 . LEU A 1 30  ? -14.79916 -39.26993 14.16033  1.000 27.11038 ? 30  LEU A CD1 1 
ATOM   215  C CD2 . LEU A 1 30  ? -17.28365 -39.11170 13.95801  1.000 24.03807 ? 30  LEU A CD2 1 
ATOM   216  N N   . TRP A 1 31  ? -14.96156 -42.94303 11.87001  1.000 28.33315 ? 31  TRP A N   1 
ATOM   217  C CA  . TRP A 1 31  ? -15.29164 -44.37452 11.92761  1.000 23.49195 ? 31  TRP A CA  1 
ATOM   218  C C   . TRP A 1 31  ? -15.75937 -44.72433 13.34018  1.000 28.72919 ? 31  TRP A C   1 
ATOM   219  O O   . TRP A 1 31  ? -14.95235 -44.82656 14.27011  1.000 29.69621 ? 31  TRP A O   1 
ATOM   220  C CB  . TRP A 1 31  ? -14.06984 -45.19113 11.51832  1.000 24.77326 ? 31  TRP A CB  1 
ATOM   221  C CG  . TRP A 1 31  ? -14.23669 -46.69198 11.51457  1.000 28.53452 ? 31  TRP A CG  1 
ATOM   222  C CD1 . TRP A 1 31  ? -15.40325 -47.40012 11.42919  1.000 28.28015 ? 31  TRP A CD1 1 
ATOM   223  C CD2 . TRP A 1 31  ? -13.18182 -47.66483 11.59008  1.000 29.89071 ? 31  TRP A CD2 1 
ATOM   224  N NE1 . TRP A 1 31  ? -15.13732 -48.75840 11.44623  1.000 27.48879 ? 31  TRP A NE1 1 
ATOM   225  C CE2 . TRP A 1 31  ? -13.78209 -48.94195 11.54417  1.000 27.26466 ? 31  TRP A CE2 1 
ATOM   226  C CE3 . TRP A 1 31  ? -11.79083 -47.57639 11.69037  1.000 32.41150 ? 31  TRP A CE3 1 
ATOM   227  C CZ2 . TRP A 1 31  ? -13.03647 -50.11779 11.60042  1.000 29.95806 ? 31  TRP A CZ2 1 
ATOM   228  C CZ3 . TRP A 1 31  ? -11.05238 -48.74332 11.74462  1.000 35.49464 ? 31  TRP A CZ3 1 
ATOM   229  C CH2 . TRP A 1 31  ? -11.68046 -50.00104 11.71003  1.000 35.33817 ? 31  TRP A CH2 1 
ATOM   230  N N   . LEU A 1 32  ? -17.06809 -44.88640 13.50103  1.000 24.34244 ? 32  LEU A N   1 
ATOM   231  C CA  . LEU A 1 32  ? -17.68734 -45.22220 14.77900  1.000 28.98635 ? 32  LEU A CA  1 
ATOM   232  C C   . LEU A 1 32  ? -18.50872 -46.49084 14.60449  1.000 27.43293 ? 32  LEU A C   1 
ATOM   233  O O   . LEU A 1 32  ? -19.40088 -46.54088 13.74706  1.000 29.93097 ? 32  LEU A O   1 
ATOM   234  C CB  . LEU A 1 32  ? -18.57605 -44.08058 15.27925  1.000 30.05912 ? 32  LEU A CB  1 
ATOM   235  C CG  . LEU A 1 32  ? -17.89622 -42.73393 15.49399  1.000 29.76729 ? 32  LEU A CG  1 
ATOM   236  C CD1 . LEU A 1 32  ? -18.95111 -41.69183 15.78134  1.000 23.60792 ? 32  LEU A CD1 1 
ATOM   237  C CD2 . LEU A 1 32  ? -16.92617 -42.84260 16.65773  1.000 28.13003 ? 32  LEU A CD2 1 
ATOM   238  N N   . ASP A 1 33  ? -18.21068 -47.50468 15.41703  1.000 30.55047 ? 33  ASP A N   1 
ATOM   239  C CA  . ASP A 1 33  ? -18.80878 -48.83849 15.27010  1.000 32.45227 ? 33  ASP A CA  1 
ATOM   240  C C   . ASP A 1 33  ? -18.52175 -49.28096 13.83595  1.000 23.42648 ? 33  ASP A C   1 
ATOM   241  O O   . ASP A 1 33  ? -17.36876 -49.16225 13.39197  1.000 28.83596 ? 33  ASP A O   1 
ATOM   242  C CB  . ASP A 1 33  ? -20.28554 -48.79149 15.66607  1.000 29.23091 ? 33  ASP A CB  1 
ATOM   243  C CG  . ASP A 1 33  ? -20.49973 -48.33712 17.10587  1.000 36.53750 ? 33  ASP A CG  1 
ATOM   244  O OD1 . ASP A 1 33  ? -19.69722 -48.73782 17.97411  1.000 39.40051 ? 33  ASP A OD1 1 
ATOM   245  O OD2 . ASP A 1 33  ? -21.47884 -47.59063 17.36418  1.000 38.78221 ? 33  ASP A OD2 1 
ATOM   246  N N   . ASP A 1 34  ? -19.51248 -49.76874 13.08460  1.000 29.06648 ? 34  ASP A N   1 
ATOM   247  C CA  . ASP A 1 34  ? -19.32915 -50.18941 11.69874  1.000 29.74718 ? 34  ASP A CA  1 
ATOM   248  C C   . ASP A 1 34  ? -19.86810 -49.16724 10.69789  1.000 28.34923 ? 34  ASP A C   1 
ATOM   249  O O   . ASP A 1 34  ? -20.36598 -49.54397 9.63662   1.000 30.25468 ? 34  ASP A O   1 
ATOM   250  C CB  . ASP A 1 34  ? -19.98128 -51.55582 11.44759  1.000 33.81376 ? 34  ASP A CB  1 
ATOM   251  C CG  . ASP A 1 34  ? -21.50421 -51.53873 11.61567  1.000 44.18721 ? 34  ASP A CG  1 
ATOM   252  O OD1 . ASP A 1 34  ? -22.03354 -50.60732 12.26812  1.000 38.53178 ? 34  ASP A OD1 1 
ATOM   253  O OD2 . ASP A 1 34  ? -22.17065 -52.47056 11.10262  1.000 37.71602 ? 34  ASP A OD2 1 
ATOM   254  N N   . VAL A 1 35  ? -19.77650 -47.87503 11.00664  1.000 25.78362 ? 35  VAL A N   1 
ATOM   255  C CA  . VAL A 1 35  ? -20.17936 -46.82742 10.07494  1.000 27.50929 ? 35  VAL A CA  1 
ATOM   256  C C   . VAL A 1 35  ? -19.06638 -45.78989 9.97432   1.000 28.64988 ? 35  VAL A C   1 
ATOM   257  O O   . VAL A 1 35  ? -18.49628 -45.37232 10.99180  1.000 27.30306 ? 35  VAL A O   1 
ATOM   258  C CB  . VAL A 1 35  ? -21.50454 -46.15223 10.48816  1.000 27.73415 ? 35  VAL A CB  1 
ATOM   259  C CG1 . VAL A 1 35  ? -21.91850 -45.12471 9.43418   1.000 28.19669 ? 35  VAL A CG1 1 
ATOM   260  C CG2 . VAL A 1 35  ? -22.62098 -47.18028 10.67315  1.000 29.88254 ? 35  VAL A CG2 1 
ATOM   261  N N   . VAL A 1 36  ? -18.76423 -45.36823 8.74848   1.000 24.49502 ? 36  VAL A N   1 
ATOM   262  C CA  . VAL A 1 36  ? -17.85614 -44.25933 8.48993   1.000 22.78519 ? 36  VAL A CA  1 
ATOM   263  C C   . VAL A 1 36  ? -18.70191 -43.07696 8.03822   1.000 25.19901 ? 36  VAL A C   1 
ATOM   264  O O   . VAL A 1 36  ? -19.48729 -43.19367 7.08847   1.000 24.25472 ? 36  VAL A O   1 
ATOM   265  C CB  . VAL A 1 36  ? -16.80670 -44.63558 7.43693   1.000 26.10081 ? 36  VAL A CB  1 
ATOM   266  C CG1 . VAL A 1 36  ? -15.96412 -43.44047 7.05627   1.000 26.92475 ? 36  VAL A CG1 1 
ATOM   267  C CG2 . VAL A 1 36  ? -15.92755 -45.76682 7.96640   1.000 24.52143 ? 36  VAL A CG2 1 
ATOM   268  N N   . TYR A 1 37  ? -18.56809 -41.95277 8.73100   1.000 27.03305 ? 37  TYR A N   1 
ATOM   269  C CA  . TYR A 1 37  ? -19.27643 -40.72543 8.39375   1.000 22.90971 ? 37  TYR A CA  1 
ATOM   270  C C   . TYR A 1 37  ? -18.30788 -39.77854 7.70496   1.000 23.15775 ? 37  TYR A C   1 
ATOM   271  O O   . TYR A 1 37  ? -17.17093 -39.62490 8.15984   1.000 28.39070 ? 37  TYR A O   1 
ATOM   272  C CB  . TYR A 1 37  ? -19.82698 -40.04692 9.64885   1.000 26.55525 ? 37  TYR A CB  1 
ATOM   273  C CG  . TYR A 1 37  ? -20.72264 -40.90892 10.48582  1.000 24.84793 ? 37  TYR A CG  1 
ATOM   274  C CD1 . TYR A 1 37  ? -20.19511 -41.86821 11.33718  1.000 28.45971 ? 37  TYR A CD1 1 
ATOM   275  C CD2 . TYR A 1 37  ? -22.10133 -40.75453 10.43533  1.000 28.73579 ? 37  TYR A CD2 1 
ATOM   276  C CE1 . TYR A 1 37  ? -21.02642 -42.67430 12.10852  1.000 28.83874 ? 37  TYR A CE1 1 
ATOM   277  C CE2 . TYR A 1 37  ? -22.95241 -41.54898 11.21821  1.000 28.05619 ? 37  TYR A CE2 1 
ATOM   278  C CZ  . TYR A 1 37  ? -22.40223 -42.50135 12.04726  1.000 31.03918 ? 37  TYR A CZ  1 
ATOM   279  O OH  . TYR A 1 37  ? -23.23150 -43.29106 12.82553  1.000 34.29316 ? 37  TYR A OH  1 
ATOM   280  N N   . CYS A 1 38  ? -18.75588 -39.13361 6.62374   1.000 27.86612 ? 38  CYS A N   1 
ATOM   281  C CA  . CYS A 1 38  ? -17.90839 -38.19313 5.89703   1.000 23.25724 ? 38  CYS A CA  1 
ATOM   282  C C   . CYS A 1 38  ? -18.79909 -37.20769 5.13688   1.000 22.11853 ? 38  CYS A C   1 
ATOM   283  O O   . CYS A 1 38  ? -19.99497 -37.46560 4.94768   1.000 26.14293 ? 38  CYS A O   1 
ATOM   284  C CB  . CYS A 1 38  ? -16.96044 -38.93058 4.94032   1.000 24.35741 ? 38  CYS A CB  1 
ATOM   285  S SG  . CYS A 1 38  ? -17.74433 -39.59492 3.42247   1.000 28.01383 ? 38  CYS A SG  1 
ATOM   286  N N   . PRO A 1 39  ? -18.24924 -36.06980 4.69753   1.000 22.91100 ? 39  PRO A N   1 
ATOM   287  C CA  . PRO A 1 39  ? -19.04851 -35.13198 3.89010   1.000 24.35132 ? 39  PRO A CA  1 
ATOM   288  C C   . PRO A 1 39  ? -19.48584 -35.76557 2.58489   1.000 23.17594 ? 39  PRO A C   1 
ATOM   289  O O   . PRO A 1 39  ? -18.71090 -36.45112 1.90976   1.000 23.07975 ? 39  PRO A O   1 
ATOM   290  C CB  . PRO A 1 39  ? -18.09001 -33.96083 3.62859   1.000 21.47301 ? 39  PRO A CB  1 
ATOM   291  C CG  . PRO A 1 39  ? -17.07136 -34.05343 4.67754   1.000 25.20982 ? 39  PRO A CG  1 
ATOM   292  C CD  . PRO A 1 39  ? -16.92710 -35.51062 5.02564   1.000 21.25954 ? 39  PRO A CD  1 
ATOM   293  N N   . ARG A 1 40  ? -20.74715 -35.53291 2.24019   1.000 23.90382 ? 40  ARG A N   1 
ATOM   294  C CA  . ARG A 1 40  ? -21.26342 -36.06405 0.99518   1.000 22.77652 ? 40  ARG A CA  1 
ATOM   295  C C   . ARG A 1 40  ? -20.53618 -35.49478 -0.21564  1.000 22.93002 ? 40  ARG A C   1 
ATOM   296  O O   . ARG A 1 40  ? -20.50340 -36.15607 -1.25798  1.000 24.03412 ? 40  ARG A O   1 
ATOM   297  C CB  . ARG A 1 40  ? -22.77322 -35.81734 0.89198   1.000 23.43260 ? 40  ARG A CB  1 
ATOM   298  C CG  . ARG A 1 40  ? -23.19544 -34.39226 0.61929   1.000 23.54149 ? 40  ARG A CG  1 
ATOM   299  C CD  . ARG A 1 40  ? -24.69351 -34.31782 0.50204   1.000 21.16889 ? 40  ARG A CD  1 
ATOM   300  N NE  . ARG A 1 40  ? -25.19187 -32.94976 0.37197   1.000 23.29178 ? 40  ARG A NE  1 
ATOM   301  C CZ  . ARG A 1 40  ? -26.42036 -32.65326 -0.03564  1.000 27.64321 ? 40  ARG A CZ  1 
ATOM   302  N NH1 . ARG A 1 40  ? -27.29833 -33.60069 -0.32582  1.000 23.50808 ? 40  ARG A NH1 1 
ATOM   303  N NH2 . ARG A 1 40  ? -26.76881 -31.37845 -0.18319  1.000 27.41698 ? 40  ARG A NH2 1 
ATOM   304  N N   . HIS A 1 41  ? -19.90062 -34.32114 -0.11183  1.000 23.33459 ? 41  HIS A N   1 
ATOM   305  C CA  . HIS A 1 41  ? -19.18962 -33.85305 -1.30020  1.000 26.62292 ? 41  HIS A CA  1 
ATOM   306  C C   . HIS A 1 41  ? -17.86206 -34.58253 -1.51899  1.000 25.58249 ? 41  HIS A C   1 
ATOM   307  O O   . HIS A 1 41  ? -17.04481 -34.13309 -2.33258  1.000 26.68799 ? 41  HIS A O   1 
ATOM   308  C CB  . HIS A 1 41  ? -18.99595 -32.32028 -1.28271  1.000 24.87922 ? 41  HIS A CB  1 
ATOM   309  C CG  . HIS A 1 41  ? -17.86844 -31.81731 -0.42170  1.000 28.31413 ? 41  HIS A CG  1 
ATOM   310  N ND1 . HIS A 1 41  ? -18.07818 -31.19817 0.79581   1.000 29.65828 ? 41  HIS A ND1 1 
ATOM   311  C CD2 . HIS A 1 41  ? -16.53252 -31.76132 -0.64310  1.000 33.21424 ? 41  HIS A CD2 1 
ATOM   312  C CE1 . HIS A 1 41  ? -16.91420 -30.83123 1.30708   1.000 29.67474 ? 41  HIS A CE1 1 
ATOM   313  N NE2 . HIS A 1 41  ? -15.96087 -31.16159 0.45346   1.000 37.21045 ? 41  HIS A NE2 1 
ATOM   314  N N   . VAL A 1 42  ? -17.63993 -35.70826 -0.83644  1.000 21.62276 ? 42  VAL A N   1 
ATOM   315  C CA  . VAL A 1 42  ? -16.57636 -36.60457 -1.26822  1.000 24.42256 ? 42  VAL A CA  1 
ATOM   316  C C   . VAL A 1 42  ? -16.83895 -37.08576 -2.69217  1.000 28.84915 ? 42  VAL A C   1 
ATOM   317  O O   . VAL A 1 42  ? -15.89786 -37.38504 -3.43178  1.000 29.98972 ? 42  VAL A O   1 
ATOM   318  C CB  . VAL A 1 42  ? -16.40213 -37.79512 -0.30185  1.000 19.62034 ? 42  VAL A CB  1 
ATOM   319  C CG1 . VAL A 1 42  ? -17.52468 -38.79342 -0.45751  1.000 20.79643 ? 42  VAL A CG1 1 
ATOM   320  C CG2 . VAL A 1 42  ? -15.05269 -38.46531 -0.57642  1.000 20.32646 ? 42  VAL A CG2 1 
ATOM   321  N N   . ILE A 1 43  ? -18.10915 -37.13951 -3.11730  1.000 27.22068 ? 43  ILE A N   1 
ATOM   322  C CA  . ILE A 1 43  ? -18.42211 -37.64742 -4.45516  1.000 29.71709 ? 43  ILE A CA  1 
ATOM   323  C C   . ILE A 1 43  ? -18.26152 -36.60093 -5.54841  1.000 32.90098 ? 43  ILE A C   1 
ATOM   324  O O   . ILE A 1 43  ? -18.44649 -36.91694 -6.73375  1.000 32.02431 ? 43  ILE A O   1 
ATOM   325  C CB  . ILE A 1 43  ? -19.85049 -38.23248 -4.50374  1.000 27.52622 ? 43  ILE A CB  1 
ATOM   326  C CG1 . ILE A 1 43  ? -20.90696 -37.13678 -4.38676  1.000 30.87658 ? 43  ILE A CG1 1 
ATOM   327  C CG2 . ILE A 1 43  ? -20.06023 -39.25838 -3.39643  1.000 22.91319 ? 43  ILE A CG2 1 
ATOM   328  C CD1 . ILE A 1 43  ? -22.33809 -37.70091 -4.48653  1.000 30.66764 ? 43  ILE A CD1 1 
ATOM   329  N N   . CYS A 1 44  ? -17.90294 -35.37614 -5.20325  1.000 28.02952 ? 44  CYS A N   1 
ATOM   330  C CA  . CYS A 1 44  ? -17.80088 -34.29762 -6.17205  1.000 26.46348 ? 44  CYS A CA  1 
ATOM   331  C C   . CYS A 1 44  ? -16.35762 -34.03968 -6.57762  1.000 36.90287 ? 44  CYS A C   1 
ATOM   332  O O   . CYS A 1 44  ? -15.42595 -34.20878 -5.78713  1.000 34.85706 ? 44  CYS A O   1 
ATOM   333  C CB  . CYS A 1 44  ? -18.37535 -33.00238 -5.61124  1.000 31.40489 ? 44  CYS A CB  1 
ATOM   334  S SG  . CYS A 1 44  ? -20.14087 -33.04385 -5.31987  1.000 31.61752 ? 44  CYS A SG  1 
ATOM   335  N N   . THR A 1 45  ? -16.19315 -33.61491 -7.82415  1.000 33.78052 ? 45  THR A N   1 
ATOM   336  C CA  . THR A 1 45  ? -14.98568 -32.95561 -8.28506  1.000 36.65645 ? 45  THR A CA  1 
ATOM   337  C C   . THR A 1 45  ? -15.11691 -31.46219 -8.02153  1.000 39.35851 ? 45  THR A C   1 
ATOM   338  O O   . THR A 1 45  ? -16.18266 -30.97026 -7.63890  1.000 34.95893 ? 45  THR A O   1 
ATOM   339  C CB  . THR A 1 45  ? -14.78011 -33.22105 -9.77060  1.000 34.78893 ? 45  THR A CB  1 
ATOM   340  O OG1 . THR A 1 45  ? -15.86036 -32.62332 -10.50002 1.000 41.47513 ? 45  THR A OG1 1 
ATOM   341  C CG2 . THR A 1 45  ? -14.79271 -34.70635 -10.02815 1.000 32.05963 ? 45  THR A CG2 1 
ATOM   342  N N   . SER A 1 46  ? -14.02224 -30.72625 -8.22865  1.000 38.00779 ? 46  SER A N   1 
ATOM   343  C CA  . SER A 1 46  ? -14.09683 -29.27546 -8.05444  1.000 40.60179 ? 46  SER A CA  1 
ATOM   344  C C   . SER A 1 46  ? -15.09333 -28.65123 -9.02330  1.000 44.26561 ? 46  SER A C   1 
ATOM   345  O O   . SER A 1 46  ? -15.76679 -27.67274 -8.67586  1.000 42.01244 ? 46  SER A O   1 
ATOM   346  C CB  . SER A 1 46  ? -12.72080 -28.64551 -8.23777  1.000 41.59057 ? 46  SER A CB  1 
ATOM   347  O OG  . SER A 1 46  ? -12.19416 -29.01540 -9.48627  1.000 51.46016 ? 46  SER A OG  1 
ATOM   348  N N   . GLU A 1 47  ? -15.20279 -29.20465 -10.23813 1.000 44.75069 ? 47  GLU A N   1 
ATOM   349  C CA  . GLU A 1 47  ? -16.20191 -28.73195 -11.19123 1.000 40.09754 ? 47  GLU A CA  1 
ATOM   350  C C   . GLU A 1 47  ? -17.61321 -29.01584 -10.69686 1.000 36.97914 ? 47  GLU A C   1 
ATOM   351  O O   . GLU A 1 47  ? -18.51966 -28.19790 -10.88367 1.000 41.13880 ? 47  GLU A O   1 
ATOM   352  C CB  . GLU A 1 47  ? -15.97911 -29.39148 -12.54960 1.000 43.30639 ? 47  GLU A CB  1 
ATOM   353  N N   . ASP A 1 48  ? -17.81847 -30.18148 -10.08187 1.000 36.99737 ? 48  ASP A N   1 
ATOM   354  C CA  . ASP A 1 48  ? -19.12556 -30.52176 -9.53108  1.000 37.35561 ? 48  ASP A CA  1 
ATOM   355  C C   . ASP A 1 48  ? -19.58845 -29.51294 -8.48715  1.000 36.07650 ? 48  ASP A C   1 
ATOM   356  O O   . ASP A 1 48  ? -20.78909 -29.23495 -8.38972  1.000 35.16542 ? 48  ASP A O   1 
ATOM   357  C CB  . ASP A 1 48  ? -19.07924 -31.91389 -8.91190  1.000 30.79652 ? 48  ASP A CB  1 
ATOM   358  C CG  . ASP A 1 48  ? -19.05106 -33.02328 -9.94697  1.000 39.63020 ? 48  ASP A CG  1 
ATOM   359  O OD1 . ASP A 1 48  ? -19.56895 -32.81347 -11.06347 1.000 35.95430 ? 48  ASP A OD1 1 
ATOM   360  O OD2 . ASP A 1 48  ? -18.52302 -34.11260 -9.63453  1.000 38.49272 ? 48  ASP A OD2 1 
ATOM   361  N N   . MET A 1 49  ? -18.65827 -28.95194 -7.70327  1.000 36.51192 ? 49  MET A N   1 
ATOM   362  C CA  . MET A 1 49  ? -19.03802 -28.14251 -6.54606  1.000 34.08976 ? 49  MET A CA  1 
ATOM   363  C C   . MET A 1 49  ? -19.71241 -26.83799 -6.93134  1.000 32.92214 ? 49  MET A C   1 
ATOM   364  O O   . MET A 1 49  ? -20.33786 -26.20615 -6.07101  1.000 30.71317 ? 49  MET A O   1 
ATOM   365  C CB  . MET A 1 49  ? -17.82036 -27.83717 -5.67206  1.000 35.88301 ? 49  MET A CB  1 
ATOM   366  C CG  . MET A 1 49  ? -17.26403 -29.04878 -4.93914  1.000 35.44040 ? 49  MET A CG  1 
ATOM   367  S SD  . MET A 1 49  ? -18.47919 -29.88351 -3.89767  1.000 37.57764 ? 49  MET A SD  1 
ATOM   368  C CE  . MET A 1 49  ? -18.85103 -28.62603 -2.67687  1.000 36.79092 ? 49  MET A CE  1 
ATOM   369  N N   . LEU A 1 50  ? -19.60254 -26.41595 -8.19385  1.000 31.70461 ? 50  LEU A N   1 
ATOM   370  C CA  . LEU A 1 50  ? -20.24597 -25.17378 -8.60945  1.000 36.25021 ? 50  LEU A CA  1 
ATOM   371  C C   . LEU A 1 50  ? -21.76584 -25.28898 -8.54095  1.000 41.22877 ? 50  LEU A C   1 
ATOM   372  O O   . LEU A 1 50  ? -22.45154 -24.33203 -8.16467  1.000 41.77658 ? 50  LEU A O   1 
ATOM   373  C CB  . LEU A 1 50  ? -19.78507 -24.80199 -10.01541 1.000 35.29267 ? 50  LEU A CB  1 
ATOM   374  C CG  . LEU A 1 50  ? -18.25552 -24.70277 -10.14048 1.000 41.15705 ? 50  LEU A CG  1 
ATOM   375  C CD1 . LEU A 1 50  ? -17.80908 -24.38033 -11.56998 1.000 43.04975 ? 50  LEU A CD1 1 
ATOM   376  C CD2 . LEU A 1 50  ? -17.68079 -23.68798 -9.15806  1.000 39.91263 ? 50  LEU A CD2 1 
ATOM   377  N N   . ASN A 1 51  ? -22.30307 -26.45912 -8.86977  1.000 37.09608 ? 51  ASN A N   1 
ATOM   378  C CA  . ASN A 1 51  ? -23.73890 -26.69613 -8.91414  1.000 36.94625 ? 51  ASN A CA  1 
ATOM   379  C C   . ASN A 1 51  ? -24.02382 -28.18996 -8.80217  1.000 38.49046 ? 51  ASN A C   1 
ATOM   380  O O   . ASN A 1 51  ? -24.43774 -28.81734 -9.78812  1.000 35.18985 ? 51  ASN A O   1 
ATOM   381  C CB  . ASN A 1 51  ? -24.32967 -26.15257 -10.21473 1.000 41.94645 ? 51  ASN A CB  1 
ATOM   382  C CG  . ASN A 1 51  ? -25.84405 -26.14462 -10.20663 1.000 50.56826 ? 51  ASN A CG  1 
ATOM   383  O OD1 . ASN A 1 51  ? -26.47207 -26.03861 -9.14720  1.000 48.52074 ? 51  ASN A OD1 1 
ATOM   384  N ND2 . ASN A 1 51  ? -26.44137 -26.26186 -11.38986 1.000 42.07704 ? 51  ASN A ND2 1 
ATOM   385  N N   . PRO A 1 52  ? -23.82103 -28.79988 -7.63603  1.000 31.26907 ? 52  PRO A N   1 
ATOM   386  C CA  . PRO A 1 52  ? -23.98760 -30.25424 -7.53429  1.000 28.64798 ? 52  PRO A CA  1 
ATOM   387  C C   . PRO A 1 52  ? -25.43818 -30.64971 -7.32388  1.000 28.63621 ? 52  PRO A C   1 
ATOM   388  O O   . PRO A 1 52  ? -26.18377 -29.99035 -6.59854  1.000 28.03920 ? 52  PRO A O   1 
ATOM   389  C CB  . PRO A 1 52  ? -23.14615 -30.61621 -6.30013  1.000 32.59593 ? 52  PRO A CB  1 
ATOM   390  C CG  . PRO A 1 52  ? -22.84585 -29.28894 -5.58431  1.000 32.32141 ? 52  PRO A CG  1 
ATOM   391  C CD  . PRO A 1 52  ? -23.54100 -28.18898 -6.32930  1.000 36.78247 ? 52  PRO A CD  1 
ATOM   392  N N   . ASN A 1 53  ? -25.83905 -31.73342 -7.98888  1.000 23.12916 ? 53  ASN A N   1 
ATOM   393  C CA  . ASN A 1 53  ? -27.08097 -32.45776 -7.69491  1.000 30.70256 ? 53  ASN A CA  1 
ATOM   394  C C   . ASN A 1 53  ? -26.65989 -33.78533 -7.06322  1.000 32.15634 ? 53  ASN A C   1 
ATOM   395  O O   . ASN A 1 53  ? -26.36893 -34.76231 -7.75628  1.000 31.74909 ? 53  ASN A O   1 
ATOM   396  C CB  . ASN A 1 53  ? -27.93807 -32.65363 -8.95851  1.000 32.12647 ? 53  ASN A CB  1 
ATOM   397  C CG  . ASN A 1 53  ? -29.24774 -33.37593 -8.67675  1.000 27.26602 ? 53  ASN A CG  1 
ATOM   398  O OD1 . ASN A 1 53  ? -29.26035 -34.42967 -8.05737  1.000 32.49963 ? 53  ASN A OD1 1 
ATOM   399  N ND2 . ASN A 1 53  ? -30.35700 -32.81112 -9.14481  1.000 31.41864 ? 53  ASN A ND2 1 
ATOM   400  N N   . TYR A 1 54  ? -26.62973 -33.81326 -5.72985  1.000 30.65197 ? 54  TYR A N   1 
ATOM   401  C CA  . TYR A 1 54  ? -25.98818 -34.92628 -5.03783  1.000 30.86473 ? 54  TYR A CA  1 
ATOM   402  C C   . TYR A 1 54  ? -26.70295 -36.24475 -5.29285  1.000 30.99289 ? 54  TYR A C   1 
ATOM   403  O O   . TYR A 1 54  ? -26.05309 -37.27739 -5.48803  1.000 30.99909 ? 54  TYR A O   1 
ATOM   404  C CB  . TYR A 1 54  ? -25.90933 -34.64198 -3.54336  1.000 33.55021 ? 54  TYR A CB  1 
ATOM   405  C CG  . TYR A 1 54  ? -24.83803 -33.64018 -3.22773  1.000 26.45816 ? 54  TYR A CG  1 
ATOM   406  C CD1 . TYR A 1 54  ? -23.51103 -34.02523 -3.13028  1.000 26.81389 ? 54  TYR A CD1 1 
ATOM   407  C CD2 . TYR A 1 54  ? -25.15008 -32.31133 -3.03908  1.000 27.27553 ? 54  TYR A CD2 1 
ATOM   408  C CE1 . TYR A 1 54  ? -22.51516 -33.09926 -2.84268  1.000 27.78536 ? 54  TYR A CE1 1 
ATOM   409  C CE2 . TYR A 1 54  ? -24.16838 -31.38307 -2.74075  1.000 28.42734 ? 54  TYR A CE2 1 
ATOM   410  C CZ  . TYR A 1 54  ? -22.85491 -31.78351 -2.65055  1.000 28.21058 ? 54  TYR A CZ  1 
ATOM   411  O OH  . TYR A 1 54  ? -21.88837 -30.83503 -2.36425  1.000 31.31922 ? 54  TYR A OH  1 
ATOM   412  N N   . GLU A 1 55  ? -28.03723 -36.24312 -5.28536  1.000 32.87566 ? 55  GLU A N   1 
ATOM   413  C CA  A GLU A 1 55  ? -28.74388 -37.48554 -5.56892  0.500 33.02059 ? 55  GLU A CA  1 
ATOM   414  C CA  B GLU A 1 55  ? -28.76929 -37.46834 -5.58316  0.500 33.02092 ? 55  GLU A CA  1 
ATOM   415  C C   . GLU A 1 55  ? -28.34246 -38.04573 -6.93052  1.000 32.57035 ? 55  GLU A C   1 
ATOM   416  O O   . GLU A 1 55  ? -28.09913 -39.25220 -7.05954  1.000 31.01403 ? 55  GLU A O   1 
ATOM   417  C CB  A GLU A 1 55  ? -30.25492 -37.27715 -5.48511  0.500 35.54398 ? 55  GLU A CB  1 
ATOM   418  C CB  B GLU A 1 55  ? -30.27259 -37.18528 -5.55564  0.500 35.46381 ? 55  GLU A CB  1 
ATOM   419  C CG  A GLU A 1 55  ? -31.01096 -38.55029 -5.12771  0.500 38.74622 ? 55  GLU A CG  1 
ATOM   420  C CG  B GLU A 1 55  ? -30.83484 -36.83240 -4.17903  0.500 32.14411 ? 55  GLU A CG  1 
ATOM   421  C CD  A GLU A 1 55  ? -30.82415 -38.95473 -3.67819  0.500 36.32263 ? 55  GLU A CD  1 
ATOM   422  C CD  B GLU A 1 55  ? -30.51098 -35.41319 -3.71012  0.500 36.89504 ? 55  GLU A CD  1 
ATOM   423  O OE1 A GLU A 1 55  ? -31.14971 -38.14023 -2.79109  0.500 46.31753 ? 55  GLU A OE1 1 
ATOM   424  O OE1 B GLU A 1 55  ? -30.00652 -34.59280 -4.51089  0.500 31.84046 ? 55  GLU A OE1 1 
ATOM   425  O OE2 A GLU A 1 55  ? -30.35810 -40.08269 -3.42075  0.500 38.56248 ? 55  GLU A OE2 1 
ATOM   426  O OE2 B GLU A 1 55  ? -30.76731 -35.11712 -2.52338  0.500 46.62922 ? 55  GLU A OE2 1 
ATOM   427  N N   . ASP A 1 56  ? -28.22261 -37.18725 -7.94635  1.000 32.39115 ? 56  ASP A N   1 
ATOM   428  C CA  . ASP A 1 56  ? -27.84832 -37.66227 -9.27384  1.000 29.90420 ? 56  ASP A CA  1 
ATOM   429  C C   . ASP A 1 56  ? -26.39955 -38.13951 -9.31149  1.000 33.39273 ? 56  ASP A C   1 
ATOM   430  O O   . ASP A 1 56  ? -26.09975 -39.17749 -9.91243  1.000 30.23881 ? 56  ASP A O   1 
ATOM   431  C CB  . ASP A 1 56  ? -28.08605 -36.56434 -10.31579 1.000 31.71056 ? 56  ASP A CB  1 
ATOM   432  C CG  . ASP A 1 56  ? -29.56350 -36.37356 -10.64607 1.000 38.29931 ? 56  ASP A CG  1 
ATOM   433  O OD1 . ASP A 1 56  ? -30.38938 -37.24736 -10.28901 1.000 35.05238 ? 56  ASP A OD1 1 
ATOM   434  O OD2 . ASP A 1 56  ? -29.89984 -35.33945 -11.25635 1.000 36.16684 ? 56  ASP A OD2 1 
ATOM   435  N N   . LEU A 1 57  ? -25.48504 -37.39744 -8.67956  1.000 30.26336 ? 57  LEU A N   1 
ATOM   436  C CA  . LEU A 1 57  ? -24.09041 -37.82682 -8.65318  1.000 32.64060 ? 57  LEU A CA  1 
ATOM   437  C C   . LEU A 1 57  ? -23.91728 -39.12704 -7.87938  1.000 33.47354 ? 57  LEU A C   1 
ATOM   438  O O   . LEU A 1 57  ? -23.01582 -39.91672 -8.18501  1.000 29.10786 ? 57  LEU A O   1 
ATOM   439  C CB  . LEU A 1 57  ? -23.21303 -36.73188 -8.04862  1.000 29.64279 ? 57  LEU A CB  1 
ATOM   440  C CG  . LEU A 1 57  ? -23.01723 -35.46936 -8.88368  1.000 33.32229 ? 57  LEU A CG  1 
ATOM   441  C CD1 . LEU A 1 57  ? -22.40296 -34.38071 -8.01061  1.000 35.52993 ? 57  LEU A CD1 1 
ATOM   442  C CD2 . LEU A 1 57  ? -22.11828 -35.77606 -10.07477 1.000 36.40896 ? 57  LEU A CD2 1 
ATOM   443  N N   . LEU A 1 58  ? -24.77076 -39.36916 -6.88569  1.000 32.50418 ? 58  LEU A N   1 
ATOM   444  C CA  . LEU A 1 58  ? -24.63617 -40.55004 -6.04247  1.000 30.79752 ? 58  LEU A CA  1 
ATOM   445  C C   . LEU A 1 58  ? -25.05898 -41.82093 -6.77018  1.000 38.31007 ? 58  LEU A C   1 
ATOM   446  O O   . LEU A 1 58  ? -24.54203 -42.90011 -6.45958  1.000 38.40480 ? 58  LEU A O   1 
ATOM   447  C CB  . LEU A 1 58  ? -25.45556 -40.36486 -4.75491  1.000 28.36672 ? 58  LEU A CB  1 
ATOM   448  C CG  . LEU A 1 58  ? -25.25615 -41.32722 -3.57648  1.000 29.93748 ? 58  LEU A CG  1 
ATOM   449  C CD1 . LEU A 1 58  ? -23.77953 -41.52718 -3.26492  1.000 28.12291 ? 58  LEU A CD1 1 
ATOM   450  C CD2 . LEU A 1 58  ? -25.99511 -40.82044 -2.33092  1.000 27.68267 ? 58  LEU A CD2 1 
ATOM   451  N N   . ILE A 1 59  ? -25.97583 -41.71101 -7.74207  1.000 33.58632 ? 59  ILE A N   1 
ATOM   452  C CA  . ILE A 1 59  ? -26.41008 -42.86977 -8.52566  1.000 33.21406 ? 59  ILE A CA  1 
ATOM   453  C C   . ILE A 1 59  ? -25.22916 -43.52256 -9.22711  1.000 37.39682 ? 59  ILE A C   1 
ATOM   454  O O   . ILE A 1 59  ? -25.21421 -44.74127 -9.44878  1.000 43.07191 ? 59  ILE A O   1 
ATOM   455  C CB  . ILE A 1 59  ? -27.48257 -42.45334 -9.55213  1.000 31.78150 ? 59  ILE A CB  1 
ATOM   456  C CG1 . ILE A 1 59  ? -28.73994 -41.94151 -8.87095  1.000 35.03325 ? 59  ILE A CG1 1 
ATOM   457  C CG2 . ILE A 1 59  ? -27.86045 -43.61396 -10.45568 1.000 40.87395 ? 59  ILE A CG2 1 
ATOM   458  C CD1 . ILE A 1 59  ? -29.77781 -41.46435 -9.88967  1.000 40.67935 ? 59  ILE A CD1 1 
ATOM   459  N N   . ARG A 1 60  ? -24.22828 -42.73538 -9.58903  1.000 29.55309 ? 60  ARG A N   1 
ATOM   460  C CA  . ARG A 1 60  ? -23.08160 -43.25667 -10.31156 1.000 32.43714 ? 60  ARG A CA  1 
ATOM   461  C C   . ARG A 1 60  ? -22.02116 -43.85338 -9.38975  1.000 43.57812 ? 60  ARG A C   1 
ATOM   462  O O   . ARG A 1 60  ? -20.94931 -44.23735 -9.87765  1.000 38.88808 ? 60  ARG A O   1 
ATOM   463  C CB  . ARG A 1 60  ? -22.48253 -42.14005 -11.16799 1.000 31.76625 ? 60  ARG A CB  1 
ATOM   464  C CG  . ARG A 1 60  ? -23.51516 -41.42457 -12.03546 1.000 39.91661 ? 60  ARG A CG  1 
ATOM   465  N N   . LYS A 1 61  ? -22.28512 -43.93021 -8.08165  1.000 38.23042 ? 61  LYS A N   1 
ATOM   466  C CA  . LYS A 1 61  ? -21.33694 -44.44732 -7.09982  1.000 33.78749 ? 61  LYS A CA  1 
ATOM   467  C C   . LYS A 1 61  ? -21.88165 -45.73394 -6.49813  1.000 38.74177 ? 61  LYS A C   1 
ATOM   468  O O   . LYS A 1 61  ? -23.03596 -45.77722 -6.05226  1.000 35.91617 ? 61  LYS A O   1 
ATOM   469  C CB  . LYS A 1 61  ? -21.06801 -43.43202 -5.97563  1.000 33.07657 ? 61  LYS A CB  1 
ATOM   470  C CG  . LYS A 1 61  ? -20.45180 -42.09858 -6.41497  1.000 29.59332 ? 61  LYS A CG  1 
ATOM   471  C CD  . LYS A 1 61  ? -19.29609 -42.26132 -7.41731  1.000 31.17677 ? 61  LYS A CD  1 
ATOM   472  C CE  . LYS A 1 61  ? -18.73667 -40.89312 -7.81969  1.000 36.02024 ? 61  LYS A CE  1 
ATOM   473  N NZ  . LYS A 1 61  ? -17.53828 -40.95550 -8.72902  1.000 42.73189 ? 61  LYS A NZ  1 
ATOM   474  N N   . SER A 1 62  ? -21.04994 -46.77085 -6.47326  1.000 30.75487 ? 62  SER A N   1 
ATOM   475  C CA  . SER A 1 62  ? -21.37688 -48.02511 -5.81698  1.000 32.89989 ? 62  SER A CA  1 
ATOM   476  C C   . SER A 1 62  ? -20.48533 -48.19599 -4.59076  1.000 29.52788 ? 62  SER A C   1 
ATOM   477  O O   . SER A 1 62  ? -19.50865 -47.46323 -4.40368  1.000 30.36152 ? 62  SER A O   1 
ATOM   478  C CB  . SER A 1 62  ? -21.21966 -49.21266 -6.78051  1.000 38.42004 ? 62  SER A CB  1 
ATOM   479  O OG  . SER A 1 62  ? -22.15308 -49.12967 -7.85133  1.000 35.97323 ? 62  SER A OG  1 
ATOM   480  N N   . ASN A 1 63  ? -20.86430 -49.15999 -3.73911  1.000 30.35509 ? 63  ASN A N   1 
ATOM   481  C CA  . ASN A 1 63  ? -20.07750 -49.48143 -2.54642  1.000 31.64745 ? 63  ASN A CA  1 
ATOM   482  C C   . ASN A 1 63  ? -18.58243 -49.53184 -2.85522  1.000 31.05983 ? 63  ASN A C   1 
ATOM   483  O O   . ASN A 1 63  ? -17.77231 -48.95569 -2.12333  1.000 28.72737 ? 63  ASN A O   1 
ATOM   484  C CB  . ASN A 1 63  ? -20.52473 -50.81723 -1.95256  1.000 30.09264 ? 63  ASN A CB  1 
ATOM   485  C CG  . ASN A 1 63  ? -21.89078 -50.74627 -1.29486  1.000 36.79103 ? 63  ASN A CG  1 
ATOM   486  O OD1 . ASN A 1 63  ? -22.34539 -49.67373 -0.90030  1.000 29.57310 ? 63  ASN A OD1 1 
ATOM   487  N ND2 . ASN A 1 63  ? -22.55000 -51.90196 -1.16374  1.000 27.12224 ? 63  ASN A ND2 1 
ATOM   488  N N   . HIS A 1 64  ? -18.19897 -50.19674 -3.94627  1.000 31.67386 ? 64  HIS A N   1 
ATOM   489  C CA  . HIS A 1 64  ? -16.77849 -50.32605 -4.24781  1.000 32.86536 ? 64  HIS A CA  1 
ATOM   490  C C   . HIS A 1 64  ? -16.14982 -49.02544 -4.73373  1.000 28.56878 ? 64  HIS A C   1 
ATOM   491  O O   . HIS A 1 64  ? -14.92592 -48.96622 -4.85057  1.000 30.79774 ? 64  HIS A O   1 
ATOM   492  C CB  . HIS A 1 64  ? -16.53984 -51.43735 -5.27914  1.000 32.92719 ? 64  HIS A CB  1 
ATOM   493  C CG  . HIS A 1 64  ? -17.08769 -51.13758 -6.64118  1.000 30.59150 ? 64  HIS A CG  1 
ATOM   494  N ND1 . HIS A 1 64  ? -18.30358 -51.61704 -7.07223  1.000 34.97734 ? 64  HIS A ND1 1 
ATOM   495  C CD2 . HIS A 1 64  ? -16.58047 -50.41647 -7.67043  1.000 33.43032 ? 64  HIS A CD2 1 
ATOM   496  C CE1 . HIS A 1 64  ? -18.52694 -51.19921 -8.30677  1.000 35.07905 ? 64  HIS A CE1 1 
ATOM   497  N NE2 . HIS A 1 64  ? -17.49854 -50.46598 -8.69207  1.000 32.45560 ? 64  HIS A NE2 1 
ATOM   498  N N   . ASN A 1 65  ? -16.93102 -47.97633 -4.99938  1.000 26.37075 ? 65  ASN A N   1 
ATOM   499  C CA  . ASN A 1 65  ? -16.31801 -46.72230 -5.42599  1.000 29.19170 ? 65  ASN A CA  1 
ATOM   500  C C   . ASN A 1 65  ? -15.78606 -45.89799 -4.25873  1.000 30.79439 ? 65  ASN A C   1 
ATOM   501  O O   . ASN A 1 65  ? -15.13928 -44.86866 -4.49038  1.000 28.70169 ? 65  ASN A O   1 
ATOM   502  C CB  . ASN A 1 65  ? -17.30999 -45.88286 -6.22920  1.000 29.53282 ? 65  ASN A CB  1 
ATOM   503  C CG  . ASN A 1 65  ? -17.57867 -46.45658 -7.60444  1.000 36.92349 ? 65  ASN A CG  1 
ATOM   504  O OD1 . ASN A 1 65  ? -18.70852 -46.82397 -7.91714  1.000 33.72689 ? 65  ASN A OD1 1 
ATOM   505  N ND2 . ASN A 1 65  ? -16.53654 -46.53672 -8.43968  1.000 34.77698 ? 65  ASN A ND2 1 
ATOM   506  N N   . PHE A 1 66  ? -16.02941 -46.33201 -3.02368  1.000 28.43490 ? 66  PHE A N   1 
ATOM   507  C CA  . PHE A 1 66  ? -15.56665 -45.63790 -1.83103  1.000 26.53448 ? 66  PHE A CA  1 
ATOM   508  C C   . PHE A 1 66  ? -14.44995 -46.46003 -1.20346  1.000 28.47962 ? 66  PHE A C   1 
ATOM   509  O O   . PHE A 1 66  ? -14.68786 -47.57650 -0.73790  1.000 28.39385 ? 66  PHE A O   1 
ATOM   510  C CB  . PHE A 1 66  ? -16.69857 -45.44731 -0.81945  1.000 24.59623 ? 66  PHE A CB  1 
ATOM   511  C CG  . PHE A 1 66  ? -17.82404 -44.56215 -1.29625  1.000 28.91976 ? 66  PHE A CG  1 
ATOM   512  C CD1 . PHE A 1 66  ? -17.75891 -43.18993 -1.13218  1.000 25.04471 ? 66  PHE A CD1 1 
ATOM   513  C CD2 . PHE A 1 66  ? -18.96524 -45.11057 -1.86262  1.000 25.21237 ? 66  PHE A CD2 1 
ATOM   514  C CE1 . PHE A 1 66  ? -18.79436 -42.37738 -1.54821  1.000 29.37975 ? 66  PHE A CE1 1 
ATOM   515  C CE2 . PHE A 1 66  ? -20.00684 -44.29974 -2.27990  1.000 27.96308 ? 66  PHE A CE2 1 
ATOM   516  C CZ  . PHE A 1 66  ? -19.91959 -42.93383 -2.11926  1.000 30.06473 ? 66  PHE A CZ  1 
ATOM   517  N N   . LEU A 1 67  ? -13.24526 -45.90658 -1.17107  1.000 24.79236 ? 67  LEU A N   1 
ATOM   518  C CA  . LEU A 1 67  ? -12.12231 -46.55596 -0.51291  1.000 28.73481 ? 67  LEU A CA  1 
ATOM   519  C C   . LEU A 1 67  ? -11.91252 -45.93438 0.85738   1.000 30.91209 ? 67  LEU A C   1 
ATOM   520  O O   . LEU A 1 67  ? -11.74849 -44.71633 0.96558   1.000 32.62537 ? 67  LEU A O   1 
ATOM   521  C CB  . LEU A 1 67  ? -10.84365 -46.41067 -1.32210  1.000 26.51839 ? 67  LEU A CB  1 
ATOM   522  C CG  . LEU A 1 67  ? -10.80449 -47.05272 -2.69603  1.000 37.38878 ? 67  LEU A CG  1 
ATOM   523  C CD1 . LEU A 1 67  ? -9.38963  -46.91619 -3.13973  1.000 35.51480 ? 67  LEU A CD1 1 
ATOM   524  C CD2 . LEU A 1 67  ? -11.23879 -48.51392 -2.62650  1.000 33.59685 ? 67  LEU A CD2 1 
ATOM   525  N N   . VAL A 1 68  ? -11.86796 -46.77350 1.88688   1.000 29.31120 ? 68  VAL A N   1 
ATOM   526  C CA  . VAL A 1 68  ? -11.74417 -46.31905 3.26408   1.000 28.75081 ? 68  VAL A CA  1 
ATOM   527  C C   . VAL A 1 68  ? -10.54360 -47.00469 3.89040   1.000 34.04324 ? 68  VAL A C   1 
ATOM   528  O O   . VAL A 1 68  ? -10.40607 -48.23205 3.80271   1.000 36.91791 ? 68  VAL A O   1 
ATOM   529  C CB  . VAL A 1 68  ? -13.02199 -46.60299 4.06952   1.000 28.20946 ? 68  VAL A CB  1 
ATOM   530  C CG1 . VAL A 1 68  ? -12.88325 -46.04982 5.47967   1.000 30.48936 ? 68  VAL A CG1 1 
ATOM   531  C CG2 . VAL A 1 68  ? -14.23428 -45.99985 3.35172   1.000 26.73625 ? 68  VAL A CG2 1 
ATOM   532  N N   . GLN A 1 69  ? -9.69502  -46.21380 4.54357   1.000 33.72223 ? 69  GLN A N   1 
ATOM   533  C CA  . GLN A 1 69  ? -8.40429  -46.68143 5.03344   1.000 41.48835 ? 69  GLN A CA  1 
ATOM   534  C C   . GLN A 1 69  ? -8.14623  -46.03999 6.38833   1.000 41.06478 ? 69  GLN A C   1 
ATOM   535  O O   . GLN A 1 69  ? -8.17158  -44.80832 6.51259   1.000 29.93223 ? 69  GLN A O   1 
ATOM   536  C CB  . GLN A 1 69  ? -7.29017  -46.33036 4.04013   1.000 34.26637 ? 69  GLN A CB  1 
ATOM   537  C CG  . GLN A 1 69  ? -6.01627  -47.11312 4.22855   1.000 53.22980 ? 69  GLN A CG  1 
ATOM   538  C CD  . GLN A 1 69  ? -5.05196  -46.91930 3.08496   1.000 50.84407 ? 69  GLN A CD  1 
ATOM   539  O OE1 . GLN A 1 69  ? -5.15978  -45.95944 2.32282   1.000 45.25961 ? 69  GLN A OE1 1 
ATOM   540  N NE2 . GLN A 1 69  ? -4.10567  -47.83534 2.95262   1.000 62.64854 ? 69  GLN A NE2 1 
ATOM   541  N N   . ALA A 1 70  ? -7.92343  -46.87308 7.40036   1.000 44.79499 ? 70  ALA A N   1 
ATOM   542  C CA  . ALA A 1 70  ? -7.65236  -46.42116 8.76564   1.000 43.50185 ? 70  ALA A CA  1 
ATOM   543  C C   . ALA A 1 70  ? -6.16064  -46.61605 8.99999   1.000 51.45096 ? 70  ALA A C   1 
ATOM   544  O O   . ALA A 1 70  ? -5.71129  -47.69552 9.37663   1.000 56.88931 ? 70  ALA A O   1 
ATOM   545  C CB  . ALA A 1 70  ? -8.48751  -47.19986 9.77428   1.000 44.79838 ? 70  ALA A CB  1 
ATOM   546  N N   . GLY A 1 71  ? -5.38517  -45.56466 8.77241   1.000 45.84623 ? 71  GLY A N   1 
ATOM   547  C CA  . GLY A 1 71  ? -3.95079  -45.74502 8.73037   1.000 45.84073 ? 71  GLY A CA  1 
ATOM   548  C C   . GLY A 1 71  ? -3.57762  -46.64195 7.56947   1.000 50.49966 ? 71  GLY A C   1 
ATOM   549  O O   . GLY A 1 71  ? -3.49336  -46.18802 6.42618   1.000 58.96216 ? 71  GLY A O   1 
ATOM   550  N N   . ASN A 1 72  ? -3.36942  -47.92347 7.83849   1.000 51.52386 ? 72  ASN A N   1 
ATOM   551  C CA  . ASN A 1 72  ? -3.06544  -48.86832 6.77994   1.000 58.77913 ? 72  ASN A CA  1 
ATOM   552  C C   . ASN A 1 72  ? -4.10368  -49.97267 6.62089   1.000 61.77503 ? 72  ASN A C   1 
ATOM   553  O O   . ASN A 1 72  ? -4.09357  -50.65206 5.59050   1.000 69.01265 ? 72  ASN A O   1 
ATOM   554  C CB  . ASN A 1 72  ? -1.67858  -49.49914 7.00089   1.000 57.59847 ? 72  ASN A CB  1 
ATOM   555  C CG  . ASN A 1 72  ? -1.52405  -50.11646 8.38257   1.000 65.50271 ? 72  ASN A CG  1 
ATOM   556  O OD1 . ASN A 1 72  ? -2.30530  -50.98222 8.77639   1.000 64.81999 ? 72  ASN A OD1 1 
ATOM   557  N ND2 . ASN A 1 72  ? -0.49603  -49.69192 9.11478   1.000 67.65535 ? 72  ASN A ND2 1 
ATOM   558  N N   . VAL A 1 73  ? -4.99940  -50.16887 7.58524   1.000 59.09590 ? 73  VAL A N   1 
ATOM   559  C CA  . VAL A 1 73  ? -6.00232  -51.22783 7.48661   1.000 56.01039 ? 73  VAL A CA  1 
ATOM   560  C C   . VAL A 1 73  ? -7.13504  -50.76232 6.57712   1.000 58.78032 ? 73  VAL A C   1 
ATOM   561  O O   . VAL A 1 73  ? -7.77920  -49.74061 6.83822   1.000 55.20463 ? 73  VAL A O   1 
ATOM   562  C CB  . VAL A 1 73  ? -6.52768  -51.63535 8.87439   1.000 64.51680 ? 73  VAL A CB  1 
ATOM   563  C CG1 . VAL A 1 73  ? -6.95809  -50.43957 9.68999   1.000 59.75808 ? 73  VAL A CG1 1 
ATOM   564  C CG2 . VAL A 1 73  ? -7.67682  -52.62243 8.74638   1.000 67.01865 ? 73  VAL A CG2 1 
ATOM   565  N N   . GLN A 1 74  ? -7.37985  -51.51024 5.50204   1.000 64.20525 ? 74  GLN A N   1 
ATOM   566  C CA  . GLN A 1 74  ? -8.41238  -51.15636 4.53702   1.000 55.78766 ? 74  GLN A CA  1 
ATOM   567  C C   . GLN A 1 74  ? -9.74923  -51.72045 4.99433   1.000 49.63875 ? 74  GLN A C   1 
ATOM   568  O O   . GLN A 1 74  ? -9.84833  -52.90474 5.33120   1.000 55.74333 ? 74  GLN A O   1 
ATOM   569  C CB  . GLN A 1 74  ? -8.06594  -51.67426 3.14046   1.000 52.65218 ? 74  GLN A CB  1 
ATOM   570  C CG  . GLN A 1 74  ? -6.81865  -51.05192 2.53900   1.000 58.76134 ? 74  GLN A CG  1 
ATOM   571  C CD  . GLN A 1 74  ? -5.54695  -51.63327 3.12822   1.000 79.34910 ? 74  GLN A CD  1 
ATOM   572  O OE1 . GLN A 1 74  ? -5.58635  -52.62626 3.86345   1.000 82.22186 ? 74  GLN A OE1 1 
ATOM   573  N NE2 . GLN A 1 74  ? -4.40997  -51.01687 2.81329   1.000 79.48968 ? 74  GLN A NE2 1 
ATOM   574  N N   . LEU A 1 75  ? -10.76776 -50.86852 5.01514   1.000 32.62499 ? 75  LEU A N   1 
ATOM   575  C CA  . LEU A 1 75  ? -12.10742 -51.25841 5.43484   1.000 36.49615 ? 75  LEU A CA  1 
ATOM   576  C C   . LEU A 1 75  ? -12.97238 -51.53142 4.21030   1.000 39.63377 ? 75  LEU A C   1 
ATOM   577  O O   . LEU A 1 75  ? -12.91108 -50.80115 3.21519   1.000 42.34309 ? 75  LEU A O   1 
ATOM   578  C CB  . LEU A 1 75  ? -12.74838 -50.17175 6.29806   1.000 39.49925 ? 75  LEU A CB  1 
ATOM   579  C CG  . LEU A 1 75  ? -11.94325 -49.77343 7.53418   1.000 42.35745 ? 75  LEU A CG  1 
ATOM   580  C CD1 . LEU A 1 75  ? -12.61209 -48.63552 8.29643   1.000 32.13793 ? 75  LEU A CD1 1 
ATOM   581  C CD2 . LEU A 1 75  ? -11.74598 -50.99131 8.42207   1.000 48.96013 ? 75  LEU A CD2 1 
ATOM   582  N N   . ARG A 1 76  ? -13.76450 -52.59480 4.28141   1.000 35.95781 ? 76  ARG A N   1 
ATOM   583  C CA  . ARG A 1 76  ? -14.60756 -53.00234 3.16893   1.000 31.04520 ? 76  ARG A CA  1 
ATOM   584  C C   . ARG A 1 76  ? -15.95909 -52.31635 3.32390   1.000 34.93943 ? 76  ARG A C   1 
ATOM   585  O O   . ARG A 1 76  ? -16.59250 -52.42523 4.38031   1.000 32.33814 ? 76  ARG A O   1 
ATOM   586  C CB  . ARG A 1 76  ? -14.76206 -54.52252 3.13784   1.000 33.11379 ? 76  ARG A CB  1 
ATOM   587  C CG  . ARG A 1 76  ? -15.56779 -55.05260 1.95529   1.000 34.29320 ? 76  ARG A CG  1 
ATOM   588  C CD  . ARG A 1 76  ? -15.73543 -56.57019 2.04994   1.000 39.94026 ? 76  ARG A CD  1 
ATOM   589  N NE  . ARG A 1 76  ? -14.45071 -57.26545 2.08577   1.000 49.03034 ? 76  ARG A NE  1 
ATOM   590  C CZ  . ARG A 1 76  ? -13.76959 -57.62275 1.00382   1.000 47.15730 ? 76  ARG A CZ  1 
ATOM   591  N NH1 . ARG A 1 76  ? -14.21681 -57.35348 -0.21143  1.000 37.09483 ? 76  ARG A NH1 1 
ATOM   592  N NH2 . ARG A 1 76  ? -12.60598 -58.25664 1.14455   1.000 44.52309 ? 76  ARG A NH2 1 
ATOM   593  N N   . VAL A 1 77  ? -16.38196 -51.59736 2.28847   1.000 38.28657 ? 77  VAL A N   1 
ATOM   594  C CA  . VAL A 1 77  ? -17.63443 -50.84683 2.30527   1.000 31.11895 ? 77  VAL A CA  1 
ATOM   595  C C   . VAL A 1 77  ? -18.75260 -51.75700 1.80859   1.000 35.27420 ? 77  VAL A C   1 
ATOM   596  O O   . VAL A 1 77  ? -18.69158 -52.27166 0.68730   1.000 31.28232 ? 77  VAL A O   1 
ATOM   597  C CB  . VAL A 1 77  ? -17.52850 -49.57893 1.44749   1.000 34.92435 ? 77  VAL A CB  1 
ATOM   598  C CG1 . VAL A 1 77  ? -18.85719 -48.81969 1.44968   1.000 32.12445 ? 77  VAL A CG1 1 
ATOM   599  C CG2 . VAL A 1 77  ? -16.39044 -48.69074 1.95304   1.000 27.34921 ? 77  VAL A CG2 1 
ATOM   600  N N   . ILE A 1 78  ? -19.78329 -51.94953 2.63689   1.000 33.51985 ? 78  ILE A N   1 
ATOM   601  C CA  . ILE A 1 78  ? -20.83952 -52.91011 2.34446   1.000 29.57536 ? 78  ILE A CA  1 
ATOM   602  C C   . ILE A 1 78  ? -22.20883 -52.25185 2.22971   1.000 32.96994 ? 78  ILE A C   1 
ATOM   603  O O   . ILE A 1 78  ? -23.21749 -52.93935 2.05692   1.000 35.09727 ? 78  ILE A O   1 
ATOM   604  C CB  . ILE A 1 78  ? -20.85756 -54.04749 3.38268   1.000 33.29137 ? 78  ILE A CB  1 
ATOM   605  C CG1 . ILE A 1 78  ? -21.24525 -53.53370 4.77277   1.000 36.54105 ? 78  ILE A CG1 1 
ATOM   606  C CG2 . ILE A 1 78  ? -19.50000 -54.69523 3.45370   1.000 28.39369 ? 78  ILE A CG2 1 
ATOM   607  C CD1 . ILE A 1 78  ? -21.45645 -54.64233 5.81493   1.000 37.27201 ? 78  ILE A CD1 1 
ATOM   608  N N   . GLY A 1 79  ? -22.26487 -50.93338 2.27403   1.000 31.10380 ? 79  GLY A N   1 
ATOM   609  C CA  . GLY A 1 79  ? -23.52425 -50.23842 2.13968   1.000 29.70002 ? 79  GLY A CA  1 
ATOM   610  C C   . GLY A 1 79  ? -23.24999 -48.76154 2.25439   1.000 31.51070 ? 79  GLY A C   1 
ATOM   611  O O   . GLY A 1 79  ? -22.25110 -48.36032 2.86043   1.000 34.39586 ? 79  GLY A O   1 
ATOM   612  N N   . HIS A 1 80  ? -24.09367 -47.93590 1.65946   1.000 26.64002 ? 80  HIS A N   1 
ATOM   613  C CA  . HIS A 1 80  ? -23.88398 -46.50458 1.77439   1.000 30.12488 ? 80  HIS A CA  1 
ATOM   614  C C   . HIS A 1 80  ? -25.22176 -45.79303 1.66225   1.000 35.25818 ? 80  HIS A C   1 
ATOM   615  O O   . HIS A 1 80  ? -26.13003 -46.23926 0.95264   1.000 37.56829 ? 80  HIS A O   1 
ATOM   616  C CB  . HIS A 1 80  ? -22.89946 -46.00218 0.71287   1.000 30.62416 ? 80  HIS A CB  1 
ATOM   617  C CG  . HIS A 1 80  ? -23.43180 -46.06091 -0.68183  1.000 31.55115 ? 80  HIS A CG  1 
ATOM   618  N ND1 . HIS A 1 80  ? -23.30270 -47.17708 -1.48152  1.000 36.79897 ? 80  HIS A ND1 1 
ATOM   619  C CD2 . HIS A 1 80  ? -24.10288 -45.14583 -1.41871  1.000 33.34509 ? 80  HIS A CD2 1 
ATOM   620  C CE1 . HIS A 1 80  ? -23.86642 -46.94519 -2.65377  1.000 32.81722 ? 80  HIS A CE1 1 
ATOM   621  N NE2 . HIS A 1 80  ? -24.34777 -45.71568 -2.64687  1.000 37.57311 ? 80  HIS A NE2 1 
ATOM   622  N N   . SER A 1 81  ? -25.32903 -44.68049 2.37572   1.000 31.26113 ? 81  SER A N   1 
ATOM   623  C CA  . SER A 1 81  ? -26.55997 -43.91713 2.41677   1.000 32.88064 ? 81  SER A CA  1 
ATOM   624  C C   . SER A 1 81  ? -26.21478 -42.44487 2.59921   1.000 35.50722 ? 81  SER A C   1 
ATOM   625  O O   . SER A 1 81  ? -25.20955 -42.10523 3.23229   1.000 33.33741 ? 81  SER A O   1 
ATOM   626  C CB  . SER A 1 81  ? -27.45787 -44.41430 3.55267   1.000 30.60453 ? 81  SER A CB  1 
ATOM   627  O OG  . SER A 1 81  ? -28.55353 -43.53819 3.73876   1.000 51.47192 ? 81  SER A OG  1 
ATOM   628  N N   . MET A 1 82  ? -27.05357 -41.57559 2.04294   1.000 28.38637 ? 82  MET A N   1 
ATOM   629  C CA  . MET A 1 82  ? -26.91596 -40.13798 2.22628   1.000 25.93169 ? 82  MET A CA  1 
ATOM   630  C C   . MET A 1 82  ? -27.92202 -39.67755 3.27171   1.000 33.34926 ? 82  MET A C   1 
ATOM   631  O O   . MET A 1 82  ? -29.12600 -39.91593 3.12936   1.000 32.18751 ? 82  MET A O   1 
ATOM   632  C CB  . MET A 1 82  ? -27.11793 -39.38834 0.90973   1.000 28.58365 ? 82  MET A CB  1 
ATOM   633  C CG  . MET A 1 82  ? -26.90530 -37.88443 1.01202   1.000 26.16615 ? 82  MET A CG  1 
ATOM   634  S SD  . MET A 1 82  ? -26.78194 -37.10640 -0.61579  1.000 33.53797 ? 82  MET A SD  1 
ATOM   635  C CE  . MET A 1 82  ? -28.27439 -37.67034 -1.42049  1.000 33.08553 ? 82  MET A CE  1 
ATOM   636  N N   . GLN A 1 83  ? -27.42979 -39.02148 4.31738   1.000 28.38251 ? 83  GLN A N   1 
ATOM   637  C CA  . GLN A 1 83  ? -28.28152 -38.44323 5.35165   1.000 31.47375 ? 83  GLN A CA  1 
ATOM   638  C C   . GLN A 1 83  ? -27.98950 -36.95683 5.40753   1.000 31.26109 ? 83  GLN A C   1 
ATOM   639  O O   . GLN A 1 83  ? -26.95212 -36.55009 5.94455   1.000 28.44472 ? 83  GLN A O   1 
ATOM   640  C CB  . GLN A 1 83  ? -28.03736 -39.07948 6.71643   1.000 34.70504 ? 83  GLN A CB  1 
ATOM   641  C CG  . GLN A 1 83  ? -28.99042 -38.54282 7.76879   1.000 39.53685 ? 83  GLN A CG  1 
ATOM   642  C CD  . GLN A 1 83  ? -28.62460 -38.95744 9.18229   1.000 43.80182 ? 83  GLN A CD  1 
ATOM   643  O OE1 . GLN A 1 83  ? -27.59363 -39.58817 9.41562   1.000 39.47050 ? 83  GLN A OE1 1 
ATOM   644  N NE2 . GLN A 1 83  ? -29.47230 -38.58679 10.14149  1.000 41.69869 ? 83  GLN A NE2 1 
ATOM   645  N N   . ASN A 1 84  ? -28.90593 -36.15290 4.87281   1.000 28.13293 ? 84  ASN A N   1 
ATOM   646  C CA  . ASN A 1 84  ? -28.73049 -34.70355 4.80359   1.000 24.51734 ? 84  ASN A CA  1 
ATOM   647  C C   . ASN A 1 84  ? -27.43503 -34.46163 4.03844   1.000 24.30149 ? 84  ASN A C   1 
ATOM   648  O O   . ASN A 1 84  ? -27.33483 -34.89336 2.87523   1.000 23.85457 ? 84  ASN A O   1 
ATOM   649  C CB  . ASN A 1 84  ? -28.79905 -34.14144 6.22310   1.000 22.64219 ? 84  ASN A CB  1 
ATOM   650  C CG  . ASN A 1 84  ? -30.13589 -34.40869 6.87600   1.000 30.90522 ? 84  ASN A CG  1 
ATOM   651  O OD1 . ASN A 1 84  ? -31.17658 -34.11294 6.30133   1.000 25.75217 ? 84  ASN A OD1 1 
ATOM   652  N ND2 . ASN A 1 84  ? -30.11516 -34.99407 8.06531   1.000 32.03118 ? 84  ASN A ND2 1 
ATOM   653  N N   . CYS A 1 85  ? -26.41903 -33.83383 4.62635   1.000 22.52712 ? 85  CYS A N   1 
ATOM   654  C CA  . CYS A 1 85  ? -25.20186 -33.55196 3.87617   1.000 20.37220 ? 85  CYS A CA  1 
ATOM   655  C C   . CYS A 1 85  ? -24.05308 -34.48712 4.23725   1.000 25.36928 ? 85  CYS A C   1 
ATOM   656  O O   . CYS A 1 85  ? -22.89933 -34.20383 3.88405   1.000 24.84418 ? 85  CYS A O   1 
ATOM   657  C CB  . CYS A 1 85  ? -24.77805 -32.09672 4.05989   1.000 24.20850 ? 85  CYS A CB  1 
ATOM   658  S SG  . CYS A 1 85  ? -25.97340 -30.92105 3.38833   1.000 26.99679 ? 85  CYS A SG  1 
ATOM   659  N N   . VAL A 1 86  ? -24.32993 -35.61267 4.89856   1.000 27.90503 ? 86  VAL A N   1 
ATOM   660  C CA  . VAL A 1 86  ? -23.26968 -36.58834 5.12962   1.000 25.23299 ? 86  VAL A CA  1 
ATOM   661  C C   . VAL A 1 86  ? -23.59593 -37.90188 4.43972   1.000 27.09119 ? 86  VAL A C   1 
ATOM   662  O O   . VAL A 1 86  ? -24.75486 -38.23330 4.15965   1.000 27.76750 ? 86  VAL A O   1 
ATOM   663  C CB  . VAL A 1 86  ? -22.95721 -36.82891 6.62770   1.000 23.83945 ? 86  VAL A CB  1 
ATOM   664  C CG1 . VAL A 1 86  ? -22.41810 -35.54988 7.26911   1.000 31.16847 ? 86  VAL A CG1 1 
ATOM   665  C CG2 . VAL A 1 86  ? -24.15258 -37.35712 7.37249   1.000 24.92791 ? 86  VAL A CG2 1 
ATOM   666  N N   . LEU A 1 87  ? -22.53115 -38.61793 4.10799   1.000 22.81142 ? 87  LEU A N   1 
ATOM   667  C CA  . LEU A 1 87  ? -22.58780 -40.01067 3.69423   1.000 28.59520 ? 87  LEU A CA  1 
ATOM   668  C C   . LEU A 1 87  ? -22.28839 -40.90267 4.88909   1.000 32.87568 ? 87  LEU A C   1 
ATOM   669  O O   . LEU A 1 87  ? -21.33438 -40.65331 5.63264   1.000 29.58882 ? 87  LEU A O   1 
ATOM   670  C CB  . LEU A 1 87  ? -21.57043 -40.28912 2.58928   1.000 30.06296 ? 87  LEU A CB  1 
ATOM   671  C CG  . LEU A 1 87  ? -22.04480 -40.42287 1.15268   1.000 37.89519 ? 87  LEU A CG  1 
ATOM   672  C CD1 . LEU A 1 87  ? -23.07029 -39.36788 0.84934   1.000 31.22843 ? 87  LEU A CD1 1 
ATOM   673  C CD2 . LEU A 1 87  ? -20.84726 -40.29419 0.21424   1.000 36.28245 ? 87  LEU A CD2 1 
ATOM   674  N N   . LYS A 1 88  ? -23.09789 -41.93892 5.07140   1.000 30.07852 ? 88  LYS A N   1 
ATOM   675  C CA  . LYS A 1 88  ? -22.81560 -42.98643 6.03970   1.000 26.04302 ? 88  LYS A CA  1 
ATOM   676  C C   . LYS A 1 88  ? -22.36924 -44.20034 5.23991   1.000 28.71498 ? 88  LYS A C   1 
ATOM   677  O O   . LYS A 1 88  ? -23.14080 -44.74580 4.44384   1.000 31.95538 ? 88  LYS A O   1 
ATOM   678  C CB  . LYS A 1 88  ? -24.03156 -43.28826 6.91397   1.000 30.99100 ? 88  LYS A CB  1 
ATOM   679  C CG  . LYS A 1 88  ? -24.44440 -42.10555 7.75670   1.000 27.11755 ? 88  LYS A CG  1 
ATOM   680  C CD  . LYS A 1 88  ? -25.58633 -42.44010 8.70435   1.000 35.37811 ? 88  LYS A CD  1 
ATOM   681  C CE  . LYS A 1 88  ? -26.89496 -42.60850 7.95237   1.000 47.91220 ? 88  LYS A CE  1 
ATOM   682  N NZ  . LYS A 1 88  ? -28.04941 -42.79939 8.88180   1.000 50.50004 ? 88  LYS A NZ  1 
ATOM   683  N N   . LEU A 1 89  ? -21.11218 -44.58736 5.41637   1.000 27.55983 ? 89  LEU A N   1 
ATOM   684  C CA  . LEU A 1 89  ? -20.54066 -45.75087 4.75025   1.000 29.78676 ? 89  LEU A CA  1 
ATOM   685  C C   . LEU A 1 89  ? -20.53279 -46.91485 5.73036   1.000 27.55879 ? 89  LEU A C   1 
ATOM   686  O O   . LEU A 1 89  ? -19.79136 -46.90696 6.71897   1.000 30.50846 ? 89  LEU A O   1 
ATOM   687  C CB  . LEU A 1 89  ? -19.13306 -45.45377 4.24580   1.000 24.00326 ? 89  LEU A CB  1 
ATOM   688  C CG  . LEU A 1 89  ? -19.00008 -44.24447 3.33513   1.000 27.25727 ? 89  LEU A CG  1 
ATOM   689  C CD1 . LEU A 1 89  ? -17.54300 -44.06824 2.88467   1.000 22.46892 ? 89  LEU A CD1 1 
ATOM   690  C CD2 . LEU A 1 89  ? -19.90806 -44.41572 2.15235   1.000 24.85659 ? 89  LEU A CD2 1 
ATOM   691  N N   . LYS A 1 90  ? -21.36275 -47.91000 5.46615   1.000 26.37961 ? 90  LYS A N   1 
ATOM   692  C CA  . LYS A 1 90  ? -21.38393 -49.09270 6.30117   1.000 28.67943 ? 90  LYS A CA  1 
ATOM   693  C C   . LYS A 1 90  ? -20.20153 -49.97624 5.91986   1.000 26.81948 ? 90  LYS A C   1 
ATOM   694  O O   . LYS A 1 90  ? -20.00814 -50.29519 4.74298   1.000 32.73819 ? 90  LYS A O   1 
ATOM   695  C CB  . LYS A 1 90  ? -22.70700 -49.83416 6.12057   1.000 31.21861 ? 90  LYS A CB  1 
ATOM   696  C CG  . LYS A 1 90  ? -22.81513 -51.12042 6.90704   1.000 34.14517 ? 90  LYS A CG  1 
ATOM   697  C CD  . LYS A 1 90  ? -23.31987 -50.88501 8.31623   1.000 43.50039 ? 90  LYS A CD  1 
ATOM   698  C CE  . LYS A 1 90  ? -24.44604 -51.85591 8.62515   1.000 48.35801 ? 90  LYS A CE  1 
ATOM   699  N NZ  . LYS A 1 90  ? -24.08733 -53.23540 8.17905   1.000 51.84267 ? 90  LYS A NZ  1 
ATOM   700  N N   . VAL A 1 91  ? -19.39871 -50.35683 6.90734   1.000 33.46872 ? 91  VAL A N   1 
ATOM   701  C CA  . VAL A 1 91  ? -18.20812 -51.15604 6.65679   1.000 29.88094 ? 91  VAL A CA  1 
ATOM   702  C C   . VAL A 1 91  ? -18.34341 -52.46913 7.41470   1.000 32.78940 ? 91  VAL A C   1 
ATOM   703  O O   . VAL A 1 91  ? -19.19960 -52.61782 8.28814   1.000 31.40635 ? 91  VAL A O   1 
ATOM   704  C CB  . VAL A 1 91  ? -16.91493 -50.40530 7.03866   1.000 30.10514 ? 91  VAL A CB  1 
ATOM   705  C CG1 . VAL A 1 91  ? -16.70080 -49.20934 6.11020   1.000 31.46405 ? 91  VAL A CG1 1 
ATOM   706  C CG2 . VAL A 1 91  ? -16.96499 -49.94866 8.48016   1.000 28.01500 ? 91  VAL A CG2 1 
ATOM   707  N N   . ASP A 1 92  ? -17.49751 -53.44311 7.04968   1.000 32.36685 ? 92  ASP A N   1 
ATOM   708  C CA  . ASP A 1 92  ? -17.62405 -54.79319 7.59598   1.000 35.06045 ? 92  ASP A CA  1 
ATOM   709  C C   . ASP A 1 92  ? -16.96097 -54.95936 8.95331   1.000 43.12114 ? 92  ASP A C   1 
ATOM   710  O O   . ASP A 1 92  ? -17.15698 -55.99775 9.59530   1.000 39.68581 ? 92  ASP A O   1 
ATOM   711  C CB  . ASP A 1 92  ? -17.02802 -55.82692 6.63177   1.000 38.81569 ? 92  ASP A CB  1 
ATOM   712  C CG  . ASP A 1 92  ? -15.53513 -55.65522 6.43907   1.000 39.53960 ? 92  ASP A CG  1 
ATOM   713  O OD1 . ASP A 1 92  ? -14.97529 -54.65206 6.92628   1.000 44.59916 ? 92  ASP A OD1 1 
ATOM   714  O OD2 . ASP A 1 92  ? -14.91809 -56.52712 5.78798   1.000 54.47579 ? 92  ASP A OD2 1 
ATOM   715  N N   . THR A 1 93  ? -16.15957 -53.99117 9.38733   1.000 37.17099 ? 93  THR A N   1 
ATOM   716  C CA  . THR A 1 93  ? -15.45157 -54.06836 10.65638  1.000 33.30485 ? 93  THR A CA  1 
ATOM   717  C C   . THR A 1 93  ? -15.93783 -52.95758 11.57486  1.000 40.05053 ? 93  THR A C   1 
ATOM   718  O O   . THR A 1 93  ? -15.95692 -51.78440 11.18225  1.000 33.29036 ? 93  THR A O   1 
ATOM   719  C CB  . THR A 1 93  ? -13.94514 -53.96211 10.44743  1.000 38.87178 ? 93  THR A CB  1 
ATOM   720  O OG1 . THR A 1 93  ? -13.54666 -54.88877 9.42865   1.000 40.82134 ? 93  THR A OG1 1 
ATOM   721  C CG2 . THR A 1 93  ? -13.19467 -54.29072 11.74555  1.000 37.38607 ? 93  THR A CG2 1 
ATOM   722  N N   . ALA A 1 94  ? -16.36964 -53.33622 12.77576  1.000 30.11664 ? 94  ALA A N   1 
ATOM   723  C CA  . ALA A 1 94  ? -16.60373 -52.35452 13.82074  1.000 31.76345 ? 94  ALA A CA  1 
ATOM   724  C C   . ALA A 1 94  ? -15.26561 -51.81819 14.28445  1.000 34.53867 ? 94  ALA A C   1 
ATOM   725  O O   . ALA A 1 94  ? -14.29238 -52.57040 14.39355  1.000 33.03831 ? 94  ALA A O   1 
ATOM   726  C CB  . ALA A 1 94  ? -17.35842 -52.98094 14.99728  1.000 39.28163 ? 94  ALA A CB  1 
ATOM   727  N N   . ASN A 1 95  ? -15.20264 -50.51595 14.52896  1.000 31.30283 ? 95  ASN A N   1 
ATOM   728  C CA  . ASN A 1 95  ? -13.93920 -49.91883 14.96791  1.000 30.64926 ? 95  ASN A CA  1 
ATOM   729  C C   . ASN A 1 95  ? -13.61699 -50.40915 16.37557  1.000 29.37618 ? 95  ASN A C   1 
ATOM   730  O O   . ASN A 1 95  ? -14.38941 -50.14348 17.30427  1.000 33.17409 ? 95  ASN A O   1 
ATOM   731  C CB  . ASN A 1 95  ? -14.03025 -48.38388 14.91663  1.000 28.51562 ? 95  ASN A CB  1 
ATOM   732  C CG  . ASN A 1 95  ? -12.71075 -47.68717 15.25555  1.000 32.55922 ? 95  ASN A CG  1 
ATOM   733  O OD1 . ASN A 1 95  ? -11.74075 -48.31221 15.67635  1.000 33.28611 ? 95  ASN A OD1 1 
ATOM   734  N ND2 . ASN A 1 95  ? -12.67887 -46.36702 15.06556  1.000 31.64545 ? 95  ASN A ND2 1 
ATOM   735  N N   . PRO A 1 96  ? -12.50898 -51.12703 16.58597  1.000 33.94791 ? 96  PRO A N   1 
ATOM   736  C CA  . PRO A 1 96  ? -12.16864 -51.55701 17.95513  1.000 33.30249 ? 96  PRO A CA  1 
ATOM   737  C C   . PRO A 1 96  ? -11.90720 -50.40144 18.89832  1.000 37.47577 ? 96  PRO A C   1 
ATOM   738  O O   . PRO A 1 96  ? -12.04768 -50.56451 20.11773  1.000 36.46000 ? 96  PRO A O   1 
ATOM   739  C CB  . PRO A 1 96  ? -10.90807 -52.41181 17.75678  1.000 33.26796 ? 96  PRO A CB  1 
ATOM   740  C CG  . PRO A 1 96  ? -10.33071 -51.95036 16.44763  1.000 32.51924 ? 96  PRO A CG  1 
ATOM   741  C CD  . PRO A 1 96  ? -11.50049 -51.55047 15.59616  1.000 34.80538 ? 96  PRO A CD  1 
ATOM   742  N N   . LYS A 1 97  ? -11.54592 -49.23172 18.37687  1.000 33.41672 ? 97  LYS A N   1 
ATOM   743  C CA  . LYS A 1 97  ? -11.22246 -48.07366 19.19837  1.000 33.39721 ? 97  LYS A CA  1 
ATOM   744  C C   . LYS A 1 97  ? -12.41042 -47.13609 19.40835  1.000 33.53853 ? 97  LYS A C   1 
ATOM   745  O O   . LYS A 1 97  ? -12.22448 -46.01929 19.90448  1.000 35.79866 ? 97  LYS A O   1 
ATOM   746  C CB  . LYS A 1 97  ? -10.05470 -47.31415 18.57231  1.000 34.88109 ? 97  LYS A CB  1 
ATOM   747  C CG  . LYS A 1 97  ? -8.73402  -48.07517 18.58147  1.000 28.07255 ? 97  LYS A CG  1 
ATOM   748  C CD  . LYS A 1 97  ? -7.79806  -47.50381 17.54223  1.000 40.33071 ? 97  LYS A CD  1 
ATOM   749  C CE  . LYS A 1 97  ? -6.49713  -48.28414 17.45675  1.000 54.43962 ? 97  LYS A CE  1 
ATOM   750  N NZ  . LYS A 1 97  ? -5.58051  -47.88581 18.56247  1.000 49.01613 ? 97  LYS A NZ  1 
ATOM   751  N N   . THR A 1 98  ? -13.61844 -47.56194 19.05911  1.000 33.61839 ? 98  THR A N   1 
ATOM   752  C CA  . THR A 1 98  ? -14.79491 -46.71920 19.22839  1.000 32.65568 ? 98  THR A CA  1 
ATOM   753  C C   . THR A 1 98  ? -14.97877 -46.33680 20.69343  1.000 39.52906 ? 98  THR A C   1 
ATOM   754  O O   . THR A 1 98  ? -15.13193 -47.22550 21.54608  1.000 37.88989 ? 98  THR A O   1 
ATOM   755  C CB  . THR A 1 98  ? -16.05157 -47.41601 18.73001  1.000 28.27546 ? 98  THR A CB  1 
ATOM   756  O OG1 . THR A 1 98  ? -15.86134 -47.86242 17.38386  1.000 32.19273 ? 98  THR A OG1 1 
ATOM   757  C CG2 . THR A 1 98  ? -17.22748 -46.46834 18.77162  1.000 30.07366 ? 98  THR A CG2 1 
ATOM   758  N N   . PRO A 1 99  ? -14.96096 -45.05392 21.03105  1.000 38.55340 ? 99  PRO A N   1 
ATOM   759  C CA  . PRO A 1 99  ? -15.21833 -44.64470 22.41019  1.000 37.21705 ? 99  PRO A CA  1 
ATOM   760  C C   . PRO A 1 99  ? -16.71484 -44.56725 22.63922  1.000 33.41886 ? 99  PRO A C   1 
ATOM   761  O O   . PRO A 1 99  ? -17.51042 -44.66457 21.70575  1.000 40.14856 ? 99  PRO A O   1 
ATOM   762  C CB  . PRO A 1 99  ? -14.58296 -43.25743 22.47513  1.000 37.34616 ? 99  PRO A CB  1 
ATOM   763  C CG  . PRO A 1 99  ? -14.89122 -42.69964 21.10056  1.000 40.15650 ? 99  PRO A CG  1 
ATOM   764  C CD  . PRO A 1 99  ? -14.80500 -43.88741 20.14111  1.000 34.89464 ? 99  PRO A CD  1 
ATOM   765  N N   . LYS A 1 100 ? -17.09668 -44.38964 23.90190  1.000 34.91991 ? 100 LYS A N   1 
ATOM   766  C CA  . LYS A 1 100 ? -18.46298 -43.96845 24.16613  1.000 33.87649 ? 100 LYS A CA  1 
ATOM   767  C C   . LYS A 1 100 ? -18.66657 -42.61420 23.50835  1.000 38.64861 ? 100 LYS A C   1 
ATOM   768  O O   . LYS A 1 100 ? -17.81541 -41.72875 23.61980  1.000 34.11339 ? 100 LYS A O   1 
ATOM   769  C CB  . LYS A 1 100 ? -18.74143 -43.88265 25.67336  1.000 38.86751 ? 100 LYS A CB  1 
ATOM   770  C CG  . LYS A 1 100 ? -18.72677 -45.22884 26.39610  1.000 47.45343 ? 100 LYS A CG  1 
ATOM   771  C CD  . LYS A 1 100 ? -18.88915 -45.07084 27.90559  1.000 45.22226 ? 100 LYS A CD  1 
ATOM   772  C CE  . LYS A 1 100 ? -18.40778 -46.32687 28.63579  1.000 53.49958 ? 100 LYS A CE  1 
ATOM   773  N NZ  . LYS A 1 100 ? -18.51327 -46.21440 30.12398  1.000 52.28223 ? 100 LYS A NZ  1 
ATOM   774  N N   . TYR A 1 101 ? -19.77833 -42.45298 22.80208  1.000 35.96160 ? 101 TYR A N   1 
ATOM   775  C CA  . TYR A 1 101 ? -19.97810 -41.20796 22.08406  1.000 39.53606 ? 101 TYR A CA  1 
ATOM   776  C C   . TYR A 1 101 ? -21.45160 -40.86420 21.99167  1.000 36.06921 ? 101 TYR A C   1 
ATOM   777  O O   . TYR A 1 101 ? -22.32775 -41.70873 22.18822  1.000 38.50300 ? 101 TYR A O   1 
ATOM   778  C CB  . TYR A 1 101 ? -19.38176 -41.26201 20.68028  1.000 30.36675 ? 101 TYR A CB  1 
ATOM   779  C CG  . TYR A 1 101 ? -20.10244 -42.19333 19.73618  1.000 36.52415 ? 101 TYR A CG  1 
ATOM   780  C CD1 . TYR A 1 101 ? -21.15282 -41.74516 18.94733  1.000 33.51913 ? 101 TYR A CD1 1 
ATOM   781  C CD2 . TYR A 1 101 ? -19.71867 -43.51528 19.61932  1.000 30.99901 ? 101 TYR A CD2 1 
ATOM   782  C CE1 . TYR A 1 101 ? -21.80630 -42.59679 18.08173  1.000 37.75402 ? 101 TYR A CE1 1 
ATOM   783  C CE2 . TYR A 1 101 ? -20.35507 -44.36497 18.75825  1.000 37.86903 ? 101 TYR A CE2 1 
ATOM   784  C CZ  . TYR A 1 101 ? -21.39404 -43.90890 17.98828  1.000 36.04140 ? 101 TYR A CZ  1 
ATOM   785  O OH  . TYR A 1 101 ? -22.02311 -44.77772 17.13008  1.000 33.42300 ? 101 TYR A OH  1 
ATOM   786  N N   . LYS A 1 102 ? -21.69890 -39.59682 21.67293  1.000 36.95182 ? 102 LYS A N   1 
ATOM   787  C CA  . LYS A 1 102 ? -23.00795 -39.09954 21.29804  1.000 30.32232 ? 102 LYS A CA  1 
ATOM   788  C C   . LYS A 1 102 ? -22.84297 -38.10569 20.15742  1.000 31.67160 ? 102 LYS A C   1 
ATOM   789  O O   . LYS A 1 102 ? -21.77907 -37.50634 19.98035  1.000 29.39257 ? 102 LYS A O   1 
ATOM   790  C CB  . LYS A 1 102 ? -23.72800 -38.42691 22.47551  1.000 30.91462 ? 102 LYS A CB  1 
ATOM   791  C CG  . LYS A 1 102 ? -24.05977 -39.37656 23.60870  1.000 38.78884 ? 102 LYS A CG  1 
ATOM   792  C CD  . LYS A 1 102 ? -25.08706 -38.79310 24.57756  1.000 45.66816 ? 102 LYS A CD  1 
ATOM   793  C CE  . LYS A 1 102 ? -24.75955 -37.36590 24.94636  1.000 43.86495 ? 102 LYS A CE  1 
ATOM   794  N NZ  . LYS A 1 102 ? -23.40355 -37.25529 25.53791  1.000 57.48343 ? 102 LYS A NZ  1 
ATOM   795  N N   . PHE A 1 103 ? -23.91702 -37.94142 19.38938  1.000 26.04026 ? 103 PHE A N   1 
ATOM   796  C CA  . PHE A 1 103 ? -24.05290 -36.87120 18.41178  1.000 28.20154 ? 103 PHE A CA  1 
ATOM   797  C C   . PHE A 1 103 ? -24.89551 -35.77363 19.04530  1.000 37.06673 ? 103 PHE A C   1 
ATOM   798  O O   . PHE A 1 103 ? -26.00771 -36.03866 19.52221  1.000 30.48941 ? 103 PHE A O   1 
ATOM   799  C CB  . PHE A 1 103 ? -24.71511 -37.36871 17.12865  1.000 34.36567 ? 103 PHE A CB  1 
ATOM   800  C CG  . PHE A 1 103 ? -23.84732 -38.28196 16.30529  1.000 27.76048 ? 103 PHE A CG  1 
ATOM   801  C CD1 . PHE A 1 103 ? -22.51611 -38.47281 16.62287  1.000 28.66914 ? 103 PHE A CD1 1 
ATOM   802  C CD2 . PHE A 1 103 ? -24.36384 -38.93680 15.20564  1.000 28.21373 ? 103 PHE A CD2 1 
ATOM   803  C CE1 . PHE A 1 103 ? -21.72161 -39.30682 15.85345  1.000 28.42427 ? 103 PHE A CE1 1 
ATOM   804  C CE2 . PHE A 1 103 ? -23.57397 -39.76256 14.43781  1.000 32.99010 ? 103 PHE A CE2 1 
ATOM   805  C CZ  . PHE A 1 103 ? -22.25043 -39.94798 14.76635  1.000 28.81831 ? 103 PHE A CZ  1 
ATOM   806  N N   . VAL A 1 104 ? -24.36191 -34.55424 19.08470  1.000 28.32282 ? 104 VAL A N   1 
ATOM   807  C CA  . VAL A 1 104 ? -25.08845 -33.42369 19.64096  1.000 28.17313 ? 104 VAL A CA  1 
ATOM   808  C C   . VAL A 1 104 ? -24.98372 -32.24864 18.69339  1.000 34.19970 ? 104 VAL A C   1 
ATOM   809  O O   . VAL A 1 104 ? -23.94630 -32.03632 18.05587  1.000 34.41236 ? 104 VAL A O   1 
ATOM   810  C CB  . VAL A 1 104 ? -24.58063 -33.03727 21.04686  1.000 32.32596 ? 104 VAL A CB  1 
ATOM   811  C CG1 . VAL A 1 104 ? -24.63286 -34.24501 21.96664  1.000 34.14903 ? 104 VAL A CG1 1 
ATOM   812  C CG2 . VAL A 1 104 ? -23.17153 -32.46483 20.98630  1.000 38.19639 ? 104 VAL A CG2 1 
ATOM   813  N N   . ARG A 1 105 ? -26.06400 -31.49034 18.59422  1.000 27.25735 ? 105 ARG A N   1 
ATOM   814  C CA  . ARG A 1 105 ? -26.09388 -30.27351 17.80896  1.000 30.27391 ? 105 ARG A CA  1 
ATOM   815  C C   . ARG A 1 105 ? -26.02580 -29.13755 18.80759  1.000 35.66615 ? 105 ARG A C   1 
ATOM   816  O O   . ARG A 1 105 ? -26.93739 -28.97254 19.62305  1.000 33.88804 ? 105 ARG A O   1 
ATOM   817  C CB  . ARG A 1 105 ? -27.35219 -30.19663 16.94737  1.000 29.85575 ? 105 ARG A CB  1 
ATOM   818  C CG  . ARG A 1 105 ? -27.50601 -28.90042 16.17170  1.000 30.53892 ? 105 ARG A CG  1 
ATOM   819  C CD  . ARG A 1 105 ? -28.67559 -28.99132 15.20538  1.000 31.16131 ? 105 ARG A CD  1 
ATOM   820  N NE  . ARG A 1 105 ? -28.78843 -27.80561 14.36511  1.000 27.34452 ? 105 ARG A NE  1 
ATOM   821  C CZ  . ARG A 1 105 ? -28.12114 -27.63764 13.23366  1.000 25.97148 ? 105 ARG A CZ  1 
ATOM   822  N NH1 . ARG A 1 105 ? -27.28131 -28.55702 12.78913  1.000 26.11612 ? 105 ARG A NH1 1 
ATOM   823  N NH2 . ARG A 1 105 ? -28.29387 -26.51839 12.53819  1.000 26.91831 ? 105 ARG A NH2 1 
ATOM   824  N N   . ILE A 1 106 ? -24.93226 -28.37985 18.76623  1.000 28.27731 ? 106 ILE A N   1 
ATOM   825  C CA  . ILE A 1 106 ? -24.67140 -27.36357 19.77521  1.000 31.27941 ? 106 ILE A CA  1 
ATOM   826  C C   . ILE A 1 106 ? -25.39517 -26.07169 19.42553  1.000 31.46447 ? 106 ILE A C   1 
ATOM   827  O O   . ILE A 1 106 ? -25.84887 -25.87830 18.29304  1.000 30.58248 ? 106 ILE A O   1 
ATOM   828  C CB  . ILE A 1 106 ? -23.16027 -27.10819 19.92464  1.000 30.28740 ? 106 ILE A CB  1 
ATOM   829  C CG1 . ILE A 1 106 ? -22.57254 -26.71287 18.56618  1.000 28.03573 ? 106 ILE A CG1 1 
ATOM   830  C CG2 . ILE A 1 106 ? -22.46013 -28.32281 20.54972  1.000 28.79779 ? 106 ILE A CG2 1 
ATOM   831  C CD1 . ILE A 1 106 ? -21.16886 -26.11741 18.63600  1.000 31.99642 ? 106 ILE A CD1 1 
ATOM   832  N N   . GLN A 1 107 ? -25.49861 -25.20972 20.36909  1.000 34.37702 ? 107 GLN A N   1 
ATOM   833  C CA  . GLN A 1 107 ? -26.03140 -23.86247 20.29119  1.000 29.77632 ? 107 GLN A CA  1 
ATOM   834  C C   . GLN A 1 107 ? -24.91985 -22.88685 19.92105  1.000 28.98002 ? 107 GLN A C   1 
ATOM   835  O O   . GLN A 1 107 ? -23.73942 -23.14512 20.19783  1.000 27.52715 ? 107 GLN A O   1 
ATOM   836  C CB  . GLN A 1 107 ? -26.64382 -23.46308 21.63179  1.000 32.69017 ? 107 GLN A CB  1 
ATOM   837  C CG  . GLN A 1 107 ? -27.70565 -24.42756 22.10890  1.000 40.35434 ? 107 GLN A CG  1 
ATOM   838  C CD  . GLN A 1 107 ? -28.96939 -24.32158 21.28743  1.000 47.92061 ? 107 GLN A CD  1 
ATOM   839  O OE1 . GLN A 1 107 ? -29.40664 -23.22090 20.93787  1.000 53.92147 ? 107 GLN A OE1 1 
ATOM   840  N NE2 . GLN A 1 107 ? -29.55847 -25.46455 20.95733  1.000 54.36047 ? 107 GLN A NE2 1 
ATOM   841  N N   . PRO A 1 108 ? -25.26838 -21.77755 19.27450  1.000 29.44785 ? 108 PRO A N   1 
ATOM   842  C CA  . PRO A 1 108 ? -24.27730 -20.72046 19.04755  1.000 28.79412 ? 108 PRO A CA  1 
ATOM   843  C C   . PRO A 1 108 ? -23.67675 -20.25075 20.36519  1.000 30.62142 ? 108 PRO A C   1 
ATOM   844  O O   . PRO A 1 108 ? -24.36232 -20.16090 21.38272  1.000 28.89652 ? 108 PRO A O   1 
ATOM   845  C CB  . PRO A 1 108 ? -25.09016 -19.61305 18.35968  1.000 32.62158 ? 108 PRO A CB  1 
ATOM   846  C CG  . PRO A 1 108 ? -26.52167 -19.93168 18.69068  1.000 40.90148 ? 108 PRO A CG  1 
ATOM   847  C CD  . PRO A 1 108 ? -26.58884 -21.41770 18.73463  1.000 28.50513 ? 108 PRO A CD  1 
ATOM   848  N N   . GLY A 1 109 ? -22.37417 -19.96427 20.34509  1.000 26.94758 ? 109 GLY A N   1 
ATOM   849  C CA  . GLY A 1 109 ? -21.65514 -19.60657 21.54487  1.000 32.54277 ? 109 GLY A CA  1 
ATOM   850  C C   . GLY A 1 109 ? -21.01307 -20.76695 22.28022  1.000 27.45480 ? 109 GLY A C   1 
ATOM   851  O O   . GLY A 1 109 ? -20.12132 -20.54357 23.10555  1.000 28.91787 ? 109 GLY A O   1 
ATOM   852  N N   . GLN A 1 110 ? -21.42901 -21.99680 22.01237  1.000 28.31772 ? 110 GLN A N   1 
ATOM   853  C CA  . GLN A 1 110 ? -20.77526 -23.13099 22.64352  1.000 31.97494 ? 110 GLN A CA  1 
ATOM   854  C C   . GLN A 1 110 ? -19.44523 -23.42241 21.95203  1.000 28.40850 ? 110 GLN A C   1 
ATOM   855  O O   . GLN A 1 110 ? -19.27474 -23.19401 20.74669  1.000 27.43619 ? 110 GLN A O   1 
ATOM   856  C CB  . GLN A 1 110 ? -21.67429 -24.36628 22.61855  1.000 33.07082 ? 110 GLN A CB  1 
ATOM   857  C CG  . GLN A 1 110 ? -22.91662 -24.25268 23.52719  1.000 40.95701 ? 110 GLN A CG  1 
ATOM   858  C CD  . GLN A 1 110 ? -23.60927 -25.59577 23.76224  1.000 53.42444 ? 110 GLN A CD  1 
ATOM   859  O OE1 . GLN A 1 110 ? -24.49857 -26.00350 22.99978  1.000 44.32610 ? 110 GLN A OE1 1 
ATOM   860  N NE2 . GLN A 1 110 ? -23.20208 -26.28957 24.82476  1.000 57.48567 ? 110 GLN A NE2 1 
ATOM   861  N N   . THR A 1 111 ? -18.49888 -23.92227 22.73694  1.000 32.16538 ? 111 THR A N   1 
ATOM   862  C CA  . THR A 1 111 ? -17.13545 -24.18063 22.29929  1.000 30.72983 ? 111 THR A CA  1 
ATOM   863  C C   . THR A 1 111 ? -16.92859 -25.67207 22.10010  1.000 27.59826 ? 111 THR A C   1 
ATOM   864  O O   . THR A 1 111 ? -17.70019 -26.49596 22.58960  1.000 28.64148 ? 111 THR A O   1 
ATOM   865  C CB  . THR A 1 111 ? -16.13642 -23.68110 23.34077  1.000 27.97488 ? 111 THR A CB  1 
ATOM   866  O OG1 . THR A 1 111 ? -16.49191 -24.25915 24.60776  1.000 27.63160 ? 111 THR A OG1 1 
ATOM   867  C CG2 . THR A 1 111 ? -16.15380 -22.15852 23.43738  1.000 20.40954 ? 111 THR A CG2 1 
ATOM   868  N N   . PHE A 1 112 ? -15.85015 -26.01490 21.40193  1.000 27.93131 ? 112 PHE A N   1 
ATOM   869  C CA  . PHE A 1 112 ? -15.52558 -27.41452 21.18342  1.000 24.05503 ? 112 PHE A CA  1 
ATOM   870  C C   . PHE A 1 112 ? -14.10763 -27.48843 20.64363  1.000 24.83842 ? 112 PHE A C   1 
ATOM   871  O O   . PHE A 1 112 ? -13.53232 -26.47404 20.23990  1.000 25.60174 ? 112 PHE A O   1 
ATOM   872  C CB  . PHE A 1 112 ? -16.52269 -28.08227 20.22274  1.000 24.19176 ? 112 PHE A CB  1 
ATOM   873  C CG  . PHE A 1 112 ? -16.63991 -27.39853 18.88425  1.000 27.33437 ? 112 PHE A CG  1 
ATOM   874  C CD1 . PHE A 1 112 ? -15.77156 -27.71499 17.84862  1.000 29.81047 ? 112 PHE A CD1 1 
ATOM   875  C CD2 . PHE A 1 112 ? -17.63064 -26.45114 18.65181  1.000 26.96539 ? 112 PHE A CD2 1 
ATOM   876  C CE1 . PHE A 1 112 ? -15.87480 -27.09269 16.61052  1.000 27.75748 ? 112 PHE A CE1 1 
ATOM   877  C CE2 . PHE A 1 112 ? -17.74534 -25.82453 17.41927  1.000 26.85096 ? 112 PHE A CE2 1 
ATOM   878  C CZ  . PHE A 1 112 ? -16.86886 -26.14040 16.39117  1.000 29.21708 ? 112 PHE A CZ  1 
ATOM   879  N N   . SER A 1 113 ? -13.53819 -28.69372 20.67866  1.000 23.93445 ? 113 SER A N   1 
ATOM   880  C CA  . SER A 1 113 ? -12.20240 -28.95222 20.15328  1.000 25.32241 ? 113 SER A CA  1 
ATOM   881  C C   . SER A 1 113 ? -12.30823 -29.46027 18.72482  1.000 22.42793 ? 113 SER A C   1 
ATOM   882  O O   . SER A 1 113 ? -13.18044 -30.27477 18.42753  1.000 23.21309 ? 113 SER A O   1 
ATOM   883  C CB  . SER A 1 113 ? -11.47559 -29.98749 21.01184  1.000 25.66792 ? 113 SER A CB  1 
ATOM   884  O OG  . SER A 1 113 ? -11.09411 -29.41880 22.24814  1.000 25.42346 ? 113 SER A OG  1 
ATOM   885  N N   . VAL A 1 114 ? -11.40806 -28.99972 17.85070  1.000 22.64043 ? 114 VAL A N   1 
ATOM   886  C CA  . VAL A 1 114 ? -11.29420 -29.51060 16.48438  1.000 20.54603 ? 114 VAL A CA  1 
ATOM   887  C C   . VAL A 1 114 ? -9.99993  -30.29895 16.37631  1.000 24.21432 ? 114 VAL A C   1 
ATOM   888  O O   . VAL A 1 114 ? -8.93494  -29.80030 16.75158  1.000 22.68320 ? 114 VAL A O   1 
ATOM   889  C CB  . VAL A 1 114 ? -11.30913 -28.38183 15.43695  1.000 24.83775 ? 114 VAL A CB  1 
ATOM   890  C CG1 . VAL A 1 114 ? -10.98323 -28.93379 14.04780  1.000 24.80200 ? 114 VAL A CG1 1 
ATOM   891  C CG2 . VAL A 1 114 ? -12.65592 -27.64192 15.43277  1.000 21.01606 ? 114 VAL A CG2 1 
ATOM   892  N N   . LEU A 1 115 ? -10.08280 -31.50745 15.83326  1.000 23.48593 ? 115 LEU A N   1 
ATOM   893  C CA  . LEU A 1 115 ? -8.89903  -32.28287 15.46940  1.000 22.59962 ? 115 LEU A CA  1 
ATOM   894  C C   . LEU A 1 115 ? -8.72113  -32.11043 13.96630  1.000 25.22053 ? 115 LEU A C   1 
ATOM   895  O O   . LEU A 1 115 ? -9.42049  -32.73785 13.16556  1.000 26.35354 ? 115 LEU A O   1 
ATOM   896  C CB  . LEU A 1 115 ? -9.05140  -33.74806 15.87291  1.000 26.29787 ? 115 LEU A CB  1 
ATOM   897  C CG  . LEU A 1 115 ? -7.83708  -34.63611 15.59148  1.000 25.35353 ? 115 LEU A CG  1 
ATOM   898  C CD1 . LEU A 1 115 ? -6.63909  -34.23233 16.44342  1.000 28.00273 ? 115 LEU A CD1 1 
ATOM   899  C CD2 . LEU A 1 115 ? -8.16673  -36.12071 15.77467  1.000 23.65165 ? 115 LEU A CD2 1 
ATOM   900  N N   . ALA A 1 116 ? -7.81713  -31.22000 13.58147  1.000 23.24417 ? 116 ALA A N   1 
ATOM   901  C CA  . ALA A 1 116 ? -7.53368  -31.02209 12.17165  1.000 23.66244 ? 116 ALA A CA  1 
ATOM   902  C C   . ALA A 1 116 ? -6.80975  -32.24604 11.63140  1.000 27.32140 ? 116 ALA A C   1 
ATOM   903  O O   . ALA A 1 116 ? -5.84124  -32.70942 12.23936  1.000 27.08737 ? 116 ALA A O   1 
ATOM   904  C CB  . ALA A 1 116 ? -6.68772  -29.76379 11.97744  1.000 29.77535 ? 116 ALA A CB  1 
ATOM   905  N N   . CYS A 1 117 ? -7.29941  -32.78263 10.50306  1.000 23.41100 ? 117 CYS A N   1 
ATOM   906  C CA  . CYS A 1 117 ? -6.74711  -33.96698 9.86573   1.000 19.40516 ? 117 CYS A CA  1 
ATOM   907  C C   . CYS A 1 117 ? -6.58349  -33.73511 8.37423   1.000 25.55963 ? 117 CYS A C   1 
ATOM   908  O O   . CYS A 1 117 ? -7.34201  -32.98336 7.75247   1.000 25.21450 ? 117 CYS A O   1 
ATOM   909  C CB  . CYS A 1 117 ? -7.65169  -35.20864 10.04175  1.000 24.84902 ? 117 CYS A CB  1 
ATOM   910  S SG  . CYS A 1 117 ? -7.85415  -35.71816 11.72085  1.000 31.14206 ? 117 CYS A SG  1 
ATOM   911  N N   . TYR A 1 118 ? -5.59606  -34.41878 7.79827   1.000 27.42134 ? 118 TYR A N   1 
ATOM   912  C CA  . TYR A 1 118 ? -5.41753  -34.47117 6.34871   1.000 30.98272 ? 118 TYR A CA  1 
ATOM   913  C C   . TYR A 1 118 ? -5.12195  -35.90677 5.96422   1.000 29.81091 ? 118 TYR A C   1 
ATOM   914  O O   . TYR A 1 118 ? -4.34274  -36.57650 6.64729   1.000 28.01823 ? 118 TYR A O   1 
ATOM   915  C CB  . TYR A 1 118 ? -4.29393  -33.52972 5.88841   1.000 28.49223 ? 118 TYR A CB  1 
ATOM   916  C CG  . TYR A 1 118 ? -4.66059  -32.12184 6.23873   1.000 33.35430 ? 118 TYR A CG  1 
ATOM   917  C CD1 . TYR A 1 118 ? -4.31629  -31.59101 7.47458   1.000 34.71187 ? 118 TYR A CD1 1 
ATOM   918  C CD2 . TYR A 1 118 ? -5.43579  -31.34686 5.37525   1.000 36.31349 ? 118 TYR A CD2 1 
ATOM   919  C CE1 . TYR A 1 118 ? -4.68641  -30.30825 7.82928   1.000 31.82529 ? 118 TYR A CE1 1 
ATOM   920  C CE2 . TYR A 1 118 ? -5.80752  -30.06185 5.71964   1.000 32.18638 ? 118 TYR A CE2 1 
ATOM   921  C CZ  . TYR A 1 118 ? -5.44055  -29.55678 6.95960   1.000 30.52930 ? 118 TYR A CZ  1 
ATOM   922  O OH  . TYR A 1 118 ? -5.80637  -28.28065 7.32664   1.000 34.38468 ? 118 TYR A OH  1 
ATOM   923  N N   . ASN A 1 119 ? -5.77920  -36.38185 4.90526   1.000 32.74972 ? 119 ASN A N   1 
ATOM   924  C CA  . ASN A 1 119 ? -5.61669  -37.75589 4.43084   1.000 37.89057 ? 119 ASN A CA  1 
ATOM   925  C C   . ASN A 1 119 ? -5.87761  -38.77941 5.52330   1.000 30.55682 ? 119 ASN A C   1 
ATOM   926  O O   . ASN A 1 119 ? -5.26113  -39.84812 5.52859   1.000 35.03729 ? 119 ASN A O   1 
ATOM   927  C CB  . ASN A 1 119 ? -4.22201  -37.98974 3.84962   1.000 34.99176 ? 119 ASN A CB  1 
ATOM   928  C CG  . ASN A 1 119 ? -3.98897  -37.20197 2.60144   1.000 41.32398 ? 119 ASN A CG  1 
ATOM   929  O OD1 . ASN A 1 119 ? -4.59692  -37.47550 1.56999   1.000 51.25559 ? 119 ASN A OD1 1 
ATOM   930  N ND2 . ASN A 1 119 ? -3.11488  -36.20201 2.68099   1.000 40.65915 ? 119 ASN A ND2 1 
ATOM   931  N N   . GLY A 1 120 ? -6.76657  -38.46777 6.47038   1.000 26.95817 ? 120 GLY A N   1 
ATOM   932  C CA  . GLY A 1 120 ? -7.08790  -39.41067 7.52219   1.000 27.11053 ? 120 GLY A CA  1 
ATOM   933  C C   . GLY A 1 120 ? -6.15653  -39.39282 8.71903   1.000 30.92874 ? 120 GLY A C   1 
ATOM   934  O O   . GLY A 1 120 ? -6.38656  -40.15253 9.67140   1.000 32.05212 ? 120 GLY A O   1 
ATOM   935  N N   . SER A 1 121 ? -5.12882  -38.54409 8.71613   1.000 25.95153 ? 121 SER A N   1 
ATOM   936  C CA  . SER A 1 121 ? -4.14609  -38.48846 9.79090   1.000 31.96884 ? 121 SER A CA  1 
ATOM   937  C C   . SER A 1 121 ? -4.24695  -37.17463 10.55248  1.000 28.90179 ? 121 SER A C   1 
ATOM   938  O O   . SER A 1 121 ? -4.31399  -36.10980 9.92756   1.000 28.00974 ? 121 SER A O   1 
ATOM   939  C CB  . SER A 1 121 ? -2.73452  -38.64508 9.22470   1.000 37.62091 ? 121 SER A CB  1 
ATOM   940  O OG  . SER A 1 121 ? -2.56153  -39.92994 8.64912   1.000 40.36640 ? 121 SER A OG  1 
ATOM   941  N N   . PRO A 1 122 ? -4.24159  -37.19752 11.88597  1.000 34.74712 ? 122 PRO A N   1 
ATOM   942  C CA  . PRO A 1 122 ? -4.39412  -35.94682 12.64569  1.000 29.91348 ? 122 PRO A CA  1 
ATOM   943  C C   . PRO A 1 122 ? -3.16092  -35.07371 12.54823  1.000 35.96340 ? 122 PRO A C   1 
ATOM   944  O O   . PRO A 1 122 ? -2.03202  -35.55079 12.67938  1.000 42.57054 ? 122 PRO A O   1 
ATOM   945  C CB  . PRO A 1 122 ? -4.60664  -36.43181 14.08553  1.000 35.23383 ? 122 PRO A CB  1 
ATOM   946  C CG  . PRO A 1 122 ? -5.07566  -37.83465 13.96456  1.000 40.63598 ? 122 PRO A CG  1 
ATOM   947  C CD  . PRO A 1 122 ? -4.34464  -38.38216 12.75424  1.000 40.79074 ? 122 PRO A CD  1 
ATOM   948  N N   . SER A 1 123 ? -3.37504  -33.77639 12.34204  1.000 25.50012 ? 123 SER A N   1 
ATOM   949  C CA  . SER A 1 123 ? -2.25457  -32.84874 12.36496  1.000 32.28013 ? 123 SER A CA  1 
ATOM   950  C C   . SER A 1 123 ? -2.20846  -31.96197 13.59763  1.000 32.54333 ? 123 SER A C   1 
ATOM   951  O O   . SER A 1 123 ? -1.11553  -31.54505 13.98911  1.000 31.33831 ? 123 SER A O   1 
ATOM   952  C CB  . SER A 1 123 ? -2.25964  -31.96028 11.11690  1.000 28.25571 ? 123 SER A CB  1 
ATOM   953  O OG  . SER A 1 123 ? -3.05866  -30.81256 11.31523  1.000 49.33795 ? 123 SER A OG  1 
ATOM   954  N N   . GLY A 1 124 ? -3.34497  -31.65040 14.22140  1.000 28.35930 ? 124 GLY A N   1 
ATOM   955  C CA  . GLY A 1 124 ? -3.30475  -30.78137 15.38262  1.000 24.34234 ? 124 GLY A CA  1 
ATOM   956  C C   . GLY A 1 124 ? -4.68427  -30.65521 15.99361  1.000 30.60273 ? 124 GLY A C   1 
ATOM   957  O O   . GLY A 1 124 ? -5.69099  -31.09247 15.42306  1.000 26.22489 ? 124 GLY A O   1 
ATOM   958  N N   . VAL A 1 125 ? -4.71993  -30.05801 17.17732  1.000 24.31907 ? 125 VAL A N   1 
ATOM   959  C CA  . VAL A 1 125 ? -5.97544  -29.86423 17.89891  1.000 22.31668 ? 125 VAL A CA  1 
ATOM   960  C C   . VAL A 1 125 ? -6.01762  -28.43904 18.44104  1.000 27.67646 ? 125 VAL A C   1 
ATOM   961  O O   . VAL A 1 125 ? -4.98993  -27.88271 18.84197  1.000 26.38882 ? 125 VAL A O   1 
ATOM   962  C CB  . VAL A 1 125 ? -6.14756  -30.93074 19.01213  1.000 24.93589 ? 125 VAL A CB  1 
ATOM   963  C CG1 . VAL A 1 125 ? -5.03675  -30.84137 20.03270  1.000 32.53015 ? 125 VAL A CG1 1 
ATOM   964  C CG2 . VAL A 1 125 ? -7.49111  -30.80525 19.69315  1.000 24.26169 ? 125 VAL A CG2 1 
ATOM   965  N N   . TYR A 1 126 ? -7.20351  -27.82842 18.39892  1.000 25.99166 ? 126 TYR A N   1 
ATOM   966  C CA  . TYR A 1 126 ? -7.39593  -26.47333 18.89877  1.000 26.32782 ? 126 TYR A CA  1 
ATOM   967  C C   . TYR A 1 126 ? -8.85382  -26.31819 19.30618  1.000 26.60860 ? 126 TYR A C   1 
ATOM   968  O O   . TYR A 1 126 ? -9.71959  -27.09456 18.89794  1.000 20.88135 ? 126 TYR A O   1 
ATOM   969  C CB  . TYR A 1 126 ? -7.00540  -25.40093 17.86168  1.000 24.78809 ? 126 TYR A CB  1 
ATOM   970  C CG  . TYR A 1 126 ? -7.71552  -25.52265 16.52543  1.000 25.63545 ? 126 TYR A CG  1 
ATOM   971  C CD1 . TYR A 1 126 ? -7.16029  -26.25737 15.48997  1.000 31.01459 ? 126 TYR A CD1 1 
ATOM   972  C CD2 . TYR A 1 126 ? -8.93427  -24.88833 16.29712  1.000 23.65804 ? 126 TYR A CD2 1 
ATOM   973  C CE1 . TYR A 1 126 ? -7.80581  -26.37631 14.27163  1.000 31.87889 ? 126 TYR A CE1 1 
ATOM   974  C CE2 . TYR A 1 126 ? -9.57701  -24.99376 15.08465  1.000 22.45382 ? 126 TYR A CE2 1 
ATOM   975  C CZ  . TYR A 1 126 ? -9.01389  -25.73635 14.07922  1.000 27.51348 ? 126 TYR A CZ  1 
ATOM   976  O OH  . TYR A 1 126 ? -9.65792  -25.84477 12.86882  1.000 29.51859 ? 126 TYR A OH  1 
ATOM   977  N N   . GLN A 1 127 ? -9.10845  -25.30175 20.12627  1.000 28.78516 ? 127 GLN A N   1 
ATOM   978  C CA  . GLN A 1 127 ? -10.42432 -25.01567 20.67680  1.000 28.18266 ? 127 GLN A CA  1 
ATOM   979  C C   . GLN A 1 127 ? -11.01765 -23.84771 19.90289  1.000 33.62923 ? 127 GLN A C   1 
ATOM   980  O O   . GLN A 1 127 ? -10.32039 -22.86355 19.62795  1.000 37.06396 ? 127 GLN A O   1 
ATOM   981  C CB  . GLN A 1 127 ? -10.29323 -24.68566 22.17085  1.000 32.67628 ? 127 GLN A CB  1 
ATOM   982  C CG  . GLN A 1 127 ? -11.56389 -24.63185 22.99875  1.000 35.67082 ? 127 GLN A CG  1 
ATOM   983  C CD  . GLN A 1 127 ? -12.14983 -25.99554 23.32622  1.000 34.38814 ? 127 GLN A CD  1 
ATOM   984  O OE1 . GLN A 1 127 ? -11.62483 -27.03545 22.91725  1.000 35.60759 ? 127 GLN A OE1 1 
ATOM   985  N NE2 . GLN A 1 127 ? -13.25746 -25.99539 24.05541  1.000 34.03772 ? 127 GLN A NE2 1 
ATOM   986  N N   . CYS A 1 128 ? -12.28208 -23.96205 19.51607  1.000 24.84912 ? 128 CYS A N   1 
ATOM   987  C CA  . CYS A 1 128 ? -12.96045 -22.83335 18.89259  1.000 27.97094 ? 128 CYS A CA  1 
ATOM   988  C C   . CYS A 1 128 ? -14.39327 -22.78624 19.40437  1.000 31.77322 ? 128 CYS A C   1 
ATOM   989  O O   . CYS A 1 128 ? -14.79309 -23.56990 20.26798  1.000 25.82956 ? 128 CYS A O   1 
ATOM   990  C CB  . CYS A 1 128 ? -12.90519 -22.93699 17.36733  1.000 34.73351 ? 128 CYS A CB  1 
ATOM   991  S SG  . CYS A 1 128 ? -13.67854 -24.40155 16.82366  1.000 41.00282 ? 128 CYS A SG  1 
ATOM   992  N N   . ALA A 1 129 ? -15.17325 -21.85881 18.85418  1.000 29.14322 ? 129 ALA A N   1 
ATOM   993  C CA  . ALA A 1 129 ? -16.55880 -21.68795 19.24778  1.000 30.42341 ? 129 ALA A CA  1 
ATOM   994  C C   . ALA A 1 129 ? -17.42896 -21.58412 18.00672  1.000 25.74196 ? 129 ALA A C   1 
ATOM   995  O O   . ALA A 1 129 ? -17.01250 -21.05827 16.97779  1.000 30.66283 ? 129 ALA A O   1 
ATOM   996  C CB  . ALA A 1 129 ? -16.73503 -20.44336 20.12686  1.000 25.62045 ? 129 ALA A CB  1 
ATOM   997  N N   . MET A 1 130 ? -18.63971 -22.10435 18.11238  1.000 23.68318 ? 130 MET A N   1 
ATOM   998  C CA  . MET A 1 130 ? -19.67026 -21.82325 17.12222  1.000 24.21919 ? 130 MET A CA  1 
ATOM   999  C C   . MET A 1 130 ? -20.06705 -20.35294 17.24137  1.000 29.53462 ? 130 MET A C   1 
ATOM   1000 O O   . MET A 1 130 ? -20.64083 -19.94247 18.25095  1.000 26.02008 ? 130 MET A O   1 
ATOM   1001 C CB  . MET A 1 130 ? -20.85906 -22.75364 17.35578  1.000 24.69611 ? 130 MET A CB  1 
ATOM   1002 C CG  . MET A 1 130 ? -22.04500 -22.53014 16.43418  1.000 31.62620 ? 130 MET A CG  1 
ATOM   1003 S SD  . MET A 1 130 ? -21.62480 -22.91597 14.73548  1.000 27.76533 ? 130 MET A SD  1 
ATOM   1004 C CE  . MET A 1 130 ? -20.99860 -24.58522 14.93671  1.000 22.08666 ? 130 MET A CE  1 
ATOM   1005 N N   . ARG A 1 131 ? -19.73529 -19.54355 16.23605  1.000 28.99208 ? 131 ARG A N   1 
ATOM   1006 C CA  . ARG A 1 131 ? -20.06875 -18.12765 16.28619  1.000 25.17121 ? 131 ARG A CA  1 
ATOM   1007 C C   . ARG A 1 131 ? -21.58698 -17.92951 16.22625  1.000 27.97174 ? 131 ARG A C   1 
ATOM   1008 O O   . ARG A 1 131 ? -22.30915 -18.76090 15.67350  1.000 28.03440 ? 131 ARG A O   1 
ATOM   1009 C CB  . ARG A 1 131 ? -19.43466 -17.37607 15.11734  1.000 22.85913 ? 131 ARG A CB  1 
ATOM   1010 C CG  . ARG A 1 131 ? -17.92077 -17.47963 14.96558  1.000 28.33145 ? 131 ARG A CG  1 
ATOM   1011 C CD  . ARG A 1 131 ? -17.17939 -17.14070 16.25004  1.000 31.03888 ? 131 ARG A CD  1 
ATOM   1012 N NE  . ARG A 1 131 ? -17.59012 -15.84969 16.79234  1.000 26.37083 ? 131 ARG A NE  1 
ATOM   1013 C CZ  . ARG A 1 131 ? -17.17302 -15.37455 17.95595  1.000 31.93608 ? 131 ARG A CZ  1 
ATOM   1014 N NH1 . ARG A 1 131 ? -16.31149 -16.04989 18.70567  1.000 27.36194 ? 131 ARG A NH1 1 
ATOM   1015 N NH2 . ARG A 1 131 ? -17.62500 -14.19324 18.37357  1.000 26.34193 ? 131 ARG A NH2 1 
ATOM   1016 N N   . PRO A 1 132 ? -22.09026 -16.80564 16.75124  1.000 29.84435 ? 132 PRO A N   1 
ATOM   1017 C CA  . PRO A 1 132 ? -23.53011 -16.51588 16.61632  1.000 27.34615 ? 132 PRO A CA  1 
ATOM   1018 C C   . PRO A 1 132 ? -24.02399 -16.44969 15.17216  1.000 32.28717 ? 132 PRO A C   1 
ATOM   1019 O O   . PRO A 1 132 ? -25.22054 -16.65626 14.93935  1.000 30.23147 ? 132 PRO A O   1 
ATOM   1020 C CB  . PRO A 1 132 ? -23.67790 -15.16192 17.32612  1.000 28.35325 ? 132 PRO A CB  1 
ATOM   1021 C CG  . PRO A 1 132 ? -22.58647 -15.18996 18.37364  1.000 27.13601 ? 132 PRO A CG  1 
ATOM   1022 C CD  . PRO A 1 132 ? -21.42323 -15.85771 17.66340  1.000 26.72665 ? 132 PRO A CD  1 
ATOM   1023 N N   . ASN A 1 133 ? -23.16493 -16.18384 14.18929  1.000 24.88609 ? 133 ASN A N   1 
ATOM   1024 C CA  . ASN A 1 133 ? -23.59981 -16.26442 12.80035  1.000 25.74025 ? 133 ASN A CA  1 
ATOM   1025 C C   . ASN A 1 133 ? -23.39386 -17.65582 12.19998  1.000 31.14376 ? 133 ASN A C   1 
ATOM   1026 O O   . ASN A 1 133 ? -23.49246 -17.80264 10.97714  1.000 29.34992 ? 133 ASN A O   1 
ATOM   1027 C CB  . ASN A 1 133 ? -22.87622 -15.21500 11.93979  1.000 30.37901 ? 133 ASN A CB  1 
ATOM   1028 C CG  . ASN A 1 133 ? -21.37449 -15.47360 11.82639  1.000 25.84750 ? 133 ASN A CG  1 
ATOM   1029 O OD1 . ASN A 1 133 ? -20.85434 -16.45480 12.37350  1.000 25.72078 ? 133 ASN A OD1 1 
ATOM   1030 N ND2 . ASN A 1 133 ? -20.67205 -14.58927 11.12782  1.000 27.14672 ? 133 ASN A ND2 1 
ATOM   1031 N N   . PHE A 1 134 ? -23.05371 -18.65049 13.02427  1.000 28.01993 ? 134 PHE A N   1 
ATOM   1032 C CA  . PHE A 1 134 ? -22.94371 -20.06955 12.65976  1.000 27.63739 ? 134 PHE A CA  1 
ATOM   1033 C C   . PHE A 1 134 ? -21.75161 -20.39330 11.76834  1.000 29.30005 ? 134 PHE A C   1 
ATOM   1034 O O   . PHE A 1 134 ? -21.74428 -21.43918 11.10606  1.000 26.40232 ? 134 PHE A O   1 
ATOM   1035 C CB  . PHE A 1 134 ? -24.21426 -20.59564 11.99079  1.000 25.63462 ? 134 PHE A CB  1 
ATOM   1036 C CG  . PHE A 1 134 ? -25.41155 -20.51656 12.86494  1.000 32.56777 ? 134 PHE A CG  1 
ATOM   1037 C CD1 . PHE A 1 134 ? -25.61963 -21.46808 13.84873  1.000 30.73170 ? 134 PHE A CD1 1 
ATOM   1038 C CD2 . PHE A 1 134 ? -26.31802 -19.47937 12.72279  1.000 33.85014 ? 134 PHE A CD2 1 
ATOM   1039 C CE1 . PHE A 1 134 ? -26.73432 -21.40223 14.67335  1.000 38.44171 ? 134 PHE A CE1 1 
ATOM   1040 C CE2 . PHE A 1 134 ? -27.42785 -19.41021 13.54023  1.000 35.51390 ? 134 PHE A CE2 1 
ATOM   1041 C CZ  . PHE A 1 134 ? -27.62843 -20.36965 14.51986  1.000 30.05303 ? 134 PHE A CZ  1 
ATOM   1042 N N   . THR A 1 135 ? -20.75012 -19.53346 11.72029  1.000 26.25925 ? 135 THR A N   1 
ATOM   1043 C CA  . THR A 1 135 ? -19.45695 -19.93259 11.19669  1.000 32.05180 ? 135 THR A CA  1 
ATOM   1044 C C   . THR A 1 135 ? -18.56920 -20.35566 12.35355  1.000 30.53026 ? 135 THR A C   1 
ATOM   1045 O O   . THR A 1 135 ? -18.91678 -20.20559 13.52506  1.000 26.18863 ? 135 THR A O   1 
ATOM   1046 C CB  . THR A 1 135 ? -18.79226 -18.79270 10.43707  1.000 23.86360 ? 135 THR A CB  1 
ATOM   1047 O OG1 . THR A 1 135 ? -18.46261 -17.75739 11.37091  1.000 29.56965 ? 135 THR A OG1 1 
ATOM   1048 C CG2 . THR A 1 135 ? -19.72557 -18.25275 9.36708   1.000 27.86015 ? 135 THR A CG2 1 
ATOM   1049 N N   . ILE A 1 136 ? -17.40508 -20.88506 12.01276  1.000 26.42768 ? 136 ILE A N   1 
ATOM   1050 C CA  . ILE A 1 136 ? -16.33930 -21.04586 12.98550  1.000 25.86638 ? 136 ILE A CA  1 
ATOM   1051 C C   . ILE A 1 136 ? -15.08858 -20.47313 12.34408  1.000 30.26055 ? 136 ILE A C   1 
ATOM   1052 O O   . ILE A 1 136 ? -14.96021 -20.43284 11.11731  1.000 29.41394 ? 136 ILE A O   1 
ATOM   1053 C CB  . ILE A 1 136 ? -16.12525 -22.51230 13.44122  1.000 31.40466 ? 136 ILE A CB  1 
ATOM   1054 C CG1 . ILE A 1 136 ? -15.58462 -23.36169 12.30997  1.000 26.92799 ? 136 ILE A CG1 1 
ATOM   1055 C CG2 . ILE A 1 136 ? -17.43234 -23.12450 13.93551  1.000 30.55507 ? 136 ILE A CG2 1 
ATOM   1056 C CD1 . ILE A 1 136 ? -15.11397 -24.71722 12.76025  1.000 28.11828 ? 136 ILE A CD1 1 
ATOM   1057 N N   . LYS A 1 137 ? -14.18666 -19.98055 13.17854  1.000 28.89960 ? 137 LYS A N   1 
ATOM   1058 C CA  . LYS A 1 137 ? -12.93467 -19.40787 12.70115  1.000 31.74637 ? 137 LYS A CA  1 
ATOM   1059 C C   . LYS A 1 137 ? -11.88194 -20.46519 12.99643  1.000 30.10810 ? 137 LYS A C   1 
ATOM   1060 O O   . LYS A 1 137 ? -11.27266 -20.48519 14.06740  1.000 30.13764 ? 137 LYS A O   1 
ATOM   1061 C CB  . LYS A 1 137 ? -12.64717 -18.06942 13.37493  1.000 36.12097 ? 137 LYS A CB  1 
ATOM   1062 C CG  . LYS A 1 137 ? -13.73165 -17.02644 13.13703  1.000 39.01069 ? 137 LYS A CG  1 
ATOM   1063 C CD  . LYS A 1 137 ? -13.50488 -15.74224 13.93244  1.000 44.54796 ? 137 LYS A CD  1 
ATOM   1064 C CE  . LYS A 1 137 ? -13.01463 -14.60432 13.04833  1.000 53.60759 ? 137 LYS A CE  1 
ATOM   1065 N NZ  . LYS A 1 137 ? -14.00763 -14.20400 12.00037  1.000 55.63444 ? 137 LYS A NZ  1 
ATOM   1066 N N   . GLY A 1 138 ? -11.69215 -21.36692 12.04017  1.000 28.63524 ? 138 GLY A N   1 
ATOM   1067 C CA  . GLY A 1 138 ? -10.83112 -22.50874 12.21074  1.000 29.94396 ? 138 GLY A CA  1 
ATOM   1068 C C   . GLY A 1 138 ? -9.50892  -22.33531 11.50115  1.000 31.08992 ? 138 GLY A C   1 
ATOM   1069 O O   . GLY A 1 138 ? -9.12257  -21.23291 11.10109  1.000 29.77638 ? 138 GLY A O   1 
ATOM   1070 N N   . SER A 1 139 ? -8.79384  -23.44681 11.36254  1.000 29.50691 ? 139 SER A N   1 
ATOM   1071 C CA  . SER A 1 139 ? -7.58872  -23.52139 10.54376  1.000 29.99539 ? 139 SER A CA  1 
ATOM   1072 C C   . SER A 1 139 ? -7.75999  -24.77346 9.69372   1.000 29.76023 ? 139 SER A C   1 
ATOM   1073 O O   . SER A 1 139 ? -7.50147  -25.88430 10.16785  1.000 26.73273 ? 139 SER A O   1 
ATOM   1074 C CB  . SER A 1 139 ? -6.32885  -23.57082 11.40243  1.000 31.19932 ? 139 SER A CB  1 
ATOM   1075 O OG  . SER A 1 139 ? -5.16098  -23.65531 10.59440  1.000 39.13362 ? 139 SER A OG  1 
ATOM   1076 N N   . PHE A 1 140 ? -8.24029  -24.59600 8.46050   1.000 26.60324 ? 140 PHE A N   1 
ATOM   1077 C CA  . PHE A 1 140 ? -8.57537  -25.70608 7.57598   1.000 27.27497 ? 140 PHE A CA  1 
ATOM   1078 C C   . PHE A 1 140 ? -7.99339  -25.43414 6.19548   1.000 30.11464 ? 140 PHE A C   1 
ATOM   1079 O O   . PHE A 1 140 ? -8.37579  -24.45657 5.54459   1.000 32.85684 ? 140 PHE A O   1 
ATOM   1080 C CB  . PHE A 1 140 ? -10.09721 -25.90053 7.47200   1.000 28.50371 ? 140 PHE A CB  1 
ATOM   1081 C CG  . PHE A 1 140 ? -10.77566 -26.32566 8.76273   1.000 29.29685 ? 140 PHE A CG  1 
ATOM   1082 C CD1 . PHE A 1 140 ? -10.68681 -27.62783 9.21484   1.000 30.45328 ? 140 PHE A CD1 1 
ATOM   1083 C CD2 . PHE A 1 140 ? -11.54259 -25.42559 9.49220   1.000 31.63624 ? 140 PHE A CD2 1 
ATOM   1084 C CE1 . PHE A 1 140 ? -11.32956 -28.02418 10.38347  1.000 26.90807 ? 140 PHE A CE1 1 
ATOM   1085 C CE2 . PHE A 1 140 ? -12.18434 -25.80826 10.66477  1.000 29.53329 ? 140 PHE A CE2 1 
ATOM   1086 C CZ  . PHE A 1 140 ? -12.08247 -27.11036 11.11060  1.000 25.88356 ? 140 PHE A CZ  1 
ATOM   1087 N N   . LEU A 1 141 ? -7.07541  -26.28467 5.74988   1.000 30.61507 ? 141 LEU A N   1 
ATOM   1088 C CA  . LEU A 1 141 ? -6.55662  -26.21870 4.38887   1.000 31.00401 ? 141 LEU A CA  1 
ATOM   1089 C C   . LEU A 1 141 ? -7.24900  -27.26634 3.53983   1.000 30.89457 ? 141 LEU A C   1 
ATOM   1090 O O   . LEU A 1 141 ? -8.03809  -28.06356 4.03672   1.000 33.15869 ? 141 LEU A O   1 
ATOM   1091 C CB  . LEU A 1 141 ? -5.04523  -26.41052 4.36304   1.000 27.15063 ? 141 LEU A CB  1 
ATOM   1092 C CG  . LEU A 1 141 ? -4.26464  -25.29229 5.04776   1.000 39.71069 ? 141 LEU A CG  1 
ATOM   1093 C CD1 . LEU A 1 141 ? -2.88536  -25.79927 5.39716   1.000 46.57887 ? 141 LEU A CD1 1 
ATOM   1094 C CD2 . LEU A 1 141 ? -4.17820  -24.04526 4.15559   1.000 33.71539 ? 141 LEU A CD2 1 
ATOM   1095 N N   . ASN A 1 142 ? -6.94367  -27.26581 2.23935   1.000 33.45709 ? 142 ASN A N   1 
ATOM   1096 C CA  . ASN A 1 142 ? -7.55891  -28.21996 1.32458   1.000 35.40364 ? 142 ASN A CA  1 
ATOM   1097 C C   . ASN A 1 142 ? -7.36431  -29.64713 1.83239   1.000 33.82839 ? 142 ASN A C   1 
ATOM   1098 O O   . ASN A 1 142 ? -6.26214  -30.03408 2.23161   1.000 37.42192 ? 142 ASN A O   1 
ATOM   1099 C CB  . ASN A 1 142 ? -6.95288  -28.06227 -0.06869  1.000 41.20265 ? 142 ASN A CB  1 
ATOM   1100 C CG  . ASN A 1 142 ? -7.89623  -28.48924 -1.16842  1.000 55.49899 ? 142 ASN A CG  1 
ATOM   1101 O OD1 . ASN A 1 142 ? -7.88503  -29.64294 -1.60664  1.000 51.06796 ? 142 ASN A OD1 1 
ATOM   1102 N ND2 . ASN A 1 142 ? -8.72256  -27.55193 -1.63094  1.000 67.73207 ? 142 ASN A ND2 1 
ATOM   1103 N N   . GLY A 1 143 ? -8.44101  -30.42834 1.83822   1.000 27.48387 ? 143 GLY A N   1 
ATOM   1104 C CA  . GLY A 1 143 ? -8.35997  -31.79568 2.30978   1.000 26.98985 ? 143 GLY A CA  1 
ATOM   1105 C C   . GLY A 1 143 ? -8.65760  -31.99590 3.78611   1.000 30.91235 ? 143 GLY A C   1 
ATOM   1106 O O   . GLY A 1 143 ? -8.69247  -33.15335 4.25022   1.000 27.52084 ? 143 GLY A O   1 
ATOM   1107 N N   . SER A 1 144 ? -8.87387  -30.91881 4.54237   1.000 29.25495 ? 144 SER A N   1 
ATOM   1108 C CA  . SER A 1 144 ? -9.26633  -31.03984 5.94579   1.000 28.27580 ? 144 SER A CA  1 
ATOM   1109 C C   . SER A 1 144 ? -10.73634 -31.39149 6.11403   1.000 24.02418 ? 144 SER A C   1 
ATOM   1110 O O   . SER A 1 144 ? -11.17558 -31.64709 7.24766   1.000 25.24606 ? 144 SER A O   1 
ATOM   1111 C CB  . SER A 1 144 ? -8.99043  -29.73424 6.69588   1.000 25.22056 ? 144 SER A CB  1 
ATOM   1112 O OG  . SER A 1 144 ? -9.78256  -28.68165 6.16714   1.000 28.24159 ? 144 SER A OG  1 
ATOM   1113 N N   . CYS A 1 145 ? -11.50715 -31.37498 5.02940   1.000 27.88918 ? 145 CYS A N   1 
ATOM   1114 C CA  . CYS A 1 145 ? -12.92637 -31.66595 5.12245   1.000 29.02655 ? 145 CYS A CA  1 
ATOM   1115 C C   . CYS A 1 145 ? -13.10928 -33.00908 5.79740   1.000 26.42365 ? 145 CYS A C   1 
ATOM   1116 O O   . CYS A 1 145 ? -12.30342 -33.92306 5.60887   1.000 25.96944 ? 145 CYS A O   1 
ATOM   1117 C CB  . CYS A 1 145 ? -13.57667 -31.66010 3.73948   1.000 33.92116 ? 145 CYS A CB  1 
ATOM   1118 S SG  . CYS A 1 145 ? -13.67332 -30.01336 3.03695   1.000 32.69539 ? 145 CYS A SG  1 
ATOM   1119 N N   . GLY A 1 146 ? -14.13590 -33.09930 6.64870   1.000 23.44995 ? 146 GLY A N   1 
ATOM   1120 C CA  . GLY A 1 146 ? -14.39484 -34.29597 7.40984   1.000 23.43937 ? 146 GLY A CA  1 
ATOM   1121 C C   . GLY A 1 146 ? -13.71873 -34.35321 8.75819   1.000 25.12299 ? 146 GLY A C   1 
ATOM   1122 O O   . GLY A 1 146 ? -14.03729 -35.25278 9.54541   1.000 25.68006 ? 146 GLY A O   1 
ATOM   1123 N N   . SER A 1 147 ? -12.78917 -33.43705 9.04385   1.000 20.98703 ? 147 SER A N   1 
ATOM   1124 C CA  . SER A 1 147 ? -12.32502 -33.24154 10.40708  1.000 19.80175 ? 147 SER A CA  1 
ATOM   1125 C C   . SER A 1 147 ? -13.52726 -32.90814 11.29072  1.000 23.74091 ? 147 SER A C   1 
ATOM   1126 O O   . SER A 1 147 ? -14.48013 -32.25067 10.85136  1.000 23.84713 ? 147 SER A O   1 
ATOM   1127 C CB  . SER A 1 147 ? -11.30294 -32.09240 10.47367  1.000 19.90127 ? 147 SER A CB  1 
ATOM   1128 O OG  . SER A 1 147 ? -10.18514 -32.30047 9.60619   1.000 24.06184 ? 147 SER A OG  1 
ATOM   1129 N N   . VAL A 1 148 ? -13.47538 -33.32551 12.55558  1.000 21.84169 ? 148 VAL A N   1 
ATOM   1130 C CA  . VAL A 1 148 ? -14.64711 -33.19615 13.41026  1.000 20.96191 ? 148 VAL A CA  1 
ATOM   1131 C C   . VAL A 1 148 ? -14.31191 -32.34188 14.62834  1.000 23.62546 ? 148 VAL A C   1 
ATOM   1132 O O   . VAL A 1 148 ? -13.15387 -32.19635 15.02905  1.000 24.17190 ? 148 VAL A O   1 
ATOM   1133 C CB  . VAL A 1 148 ? -15.23779 -34.55976 13.84507  1.000 25.57237 ? 148 VAL A CB  1 
ATOM   1134 C CG1 . VAL A 1 148 ? -15.66735 -35.37517 12.63122  1.000 20.14277 ? 148 VAL A CG1 1 
ATOM   1135 C CG2 . VAL A 1 148 ? -14.27156 -35.33346 14.69164  1.000 26.71333 ? 148 VAL A CG2 1 
ATOM   1136 N N   . GLY A 1 149 ? -15.35753 -31.74869 15.20369  1.000 21.94458 ? 149 GLY A N   1 
ATOM   1137 C CA  . GLY A 1 149 ? -15.27061 -31.06745 16.48360  1.000 18.84594 ? 149 GLY A CA  1 
ATOM   1138 C C   . GLY A 1 149 ? -16.02304 -31.85796 17.53987  1.000 23.90634 ? 149 GLY A C   1 
ATOM   1139 O O   . GLY A 1 149 ? -17.00908 -32.53140 17.23465  1.000 22.29910 ? 149 GLY A O   1 
ATOM   1140 N N   . PHE A 1 150 ? -15.56905 -31.76312 18.79267  1.000 21.00666 ? 150 PHE A N   1 
ATOM   1141 C CA  . PHE A 1 150 ? -16.10364 -32.62776 19.83815  1.000 26.13853 ? 150 PHE A CA  1 
ATOM   1142 C C   . PHE A 1 150 ? -15.92472 -31.98926 21.21305  1.000 24.81722 ? 150 PHE A C   1 
ATOM   1143 O O   . PHE A 1 150 ? -15.04337 -31.15781 21.42749  1.000 21.75559 ? 150 PHE A O   1 
ATOM   1144 C CB  . PHE A 1 150 ? -15.41465 -33.99630 19.82326  1.000 25.56361 ? 150 PHE A CB  1 
ATOM   1145 C CG  . PHE A 1 150 ? -13.92694 -33.91498 20.00972  1.000 24.53979 ? 150 PHE A CG  1 
ATOM   1146 C CD1 . PHE A 1 150 ? -13.10216 -33.60670 18.93808  1.000 22.71482 ? 150 PHE A CD1 1 
ATOM   1147 C CD2 . PHE A 1 150 ? -13.35537 -34.13435 21.25712  1.000 25.59121 ? 150 PHE A CD2 1 
ATOM   1148 C CE1 . PHE A 1 150 ? -11.72828 -33.49748 19.10316  1.000 29.72894 ? 150 PHE A CE1 1 
ATOM   1149 C CE2 . PHE A 1 150 ? -11.97572 -34.04034 21.42899  1.000 26.47770 ? 150 PHE A CE2 1 
ATOM   1150 C CZ  . PHE A 1 150 ? -11.16670 -33.72200 20.35612  1.000 27.29581 ? 150 PHE A CZ  1 
ATOM   1151 N N   . ASN A 1 151 ? -16.75438 -32.42373 22.14920  1.000 26.54159 ? 151 ASN A N   1 
ATOM   1152 C CA  . ASN A 1 151 ? -16.49726 -32.24032 23.56801  1.000 30.73913 ? 151 ASN A CA  1 
ATOM   1153 C C   . ASN A 1 151 ? -16.40655 -33.61366 24.22468  1.000 31.03221 ? 151 ASN A C   1 
ATOM   1154 O O   . ASN A 1 151 ? -16.92346 -34.60581 23.70149  1.000 27.66573 ? 151 ASN A O   1 
ATOM   1155 C CB  . ASN A 1 151 ? -17.59571 -31.40991 24.23769  1.000 27.66860 ? 151 ASN A CB  1 
ATOM   1156 C CG  . ASN A 1 151 ? -17.54936 -29.95070 23.84737  1.000 32.63453 ? 151 ASN A CG  1 
ATOM   1157 O OD1 . ASN A 1 151 ? -16.88081 -29.14501 24.49477  1.000 31.22496 ? 151 ASN A OD1 1 
ATOM   1158 N ND2 . ASN A 1 151 ? -18.27374 -29.59492 22.79568  1.000 30.84948 ? 151 ASN A ND2 1 
ATOM   1159 N N   . ILE A 1 152 ? -15.73427 -33.66846 25.37459  1.000 34.85409 ? 152 ILE A N   1 
ATOM   1160 C CA  . ILE A 1 152 ? -15.59170 -34.90092 26.14159  1.000 33.21073 ? 152 ILE A CA  1 
ATOM   1161 C C   . ILE A 1 152 ? -16.09386 -34.65740 27.55329  1.000 41.77278 ? 152 ILE A C   1 
ATOM   1162 O O   . ILE A 1 152 ? -15.73296 -33.65678 28.18202  1.000 41.36793 ? 152 ILE A O   1 
ATOM   1163 C CB  . ILE A 1 152 ? -14.14182 -35.40463 26.19018  1.000 36.10477 ? 152 ILE A CB  1 
ATOM   1164 C CG1 . ILE A 1 152 ? -13.53563 -35.47194 24.79284  1.000 28.90055 ? 152 ILE A CG1 1 
ATOM   1165 C CG2 . ILE A 1 152 ? -14.09737 -36.77068 26.85123  1.000 39.66646 ? 152 ILE A CG2 1 
ATOM   1166 C CD1 . ILE A 1 152 ? -12.20473 -36.19005 24.75737  1.000 33.34723 ? 152 ILE A CD1 1 
ATOM   1167 N N   . ASP A 1 153 ? -16.92596 -35.57198 28.04453  1.000 49.48649 ? 153 ASP A N   1 
ATOM   1168 C CA  . ASP A 1 153 ? -17.32475 -35.62132 29.44689  1.000 44.22789 ? 153 ASP A CA  1 
ATOM   1169 C C   . ASP A 1 153 ? -16.91906 -36.98055 30.00550  1.000 45.98033 ? 153 ASP A C   1 
ATOM   1170 O O   . ASP A 1 153 ? -17.48759 -38.00838 29.61837  1.000 50.80760 ? 153 ASP A O   1 
ATOM   1171 C CB  . ASP A 1 153 ? -18.82217 -35.38544 29.60932  1.000 48.62641 ? 153 ASP A CB  1 
ATOM   1172 C CG  . ASP A 1 153 ? -19.25759 -35.46542 31.05947  1.000 60.46773 ? 153 ASP A CG  1 
ATOM   1173 O OD1 . ASP A 1 153 ? -18.74904 -34.66390 31.87697  1.000 54.19574 ? 153 ASP A OD1 1 
ATOM   1174 O OD2 . ASP A 1 153 ? -20.09047 -36.33963 31.38326  1.000 64.34065 ? 153 ASP A OD2 1 
ATOM   1175 N N   . TYR A 1 154 ? -15.94538 -36.97687 30.92206  1.000 38.24710 ? 154 TYR A N   1 
ATOM   1176 C CA  . TYR A 1 154 ? -15.34220 -38.19021 31.46917  1.000 41.24595 ? 154 TYR A CA  1 
ATOM   1177 C C   . TYR A 1 154 ? -14.85756 -39.11817 30.36173  1.000 41.02208 ? 154 TYR A C   1 
ATOM   1178 O O   . TYR A 1 154 ? -13.72639 -38.99065 29.88014  1.000 45.59025 ? 154 TYR A O   1 
ATOM   1179 C CB  . TYR A 1 154 ? -16.32348 -38.92662 32.37941  1.000 49.23950 ? 154 TYR A CB  1 
ATOM   1180 N N   . ASP A 1 155 ? -15.70825 -40.04955 29.94000  1.000 44.02041 ? 155 ASP A N   1 
ATOM   1181 C CA  . ASP A 1 155 ? -15.32686 -41.02640 28.92982  1.000 49.44045 ? 155 ASP A CA  1 
ATOM   1182 C C   . ASP A 1 155 ? -16.20190 -40.96685 27.68378  1.000 43.53731 ? 155 ASP A C   1 
ATOM   1183 O O   . ASP A 1 155 ? -16.06631 -41.83147 26.80982  1.000 47.65491 ? 155 ASP A O   1 
ATOM   1184 C CB  . ASP A 1 155 ? -15.36307 -42.43694 29.52396  1.000 44.63122 ? 155 ASP A CB  1 
ATOM   1185 C CG  . ASP A 1 155 ? -16.71699 -42.78449 30.11980  1.000 48.28502 ? 155 ASP A CG  1 
ATOM   1186 O OD1 . ASP A 1 155 ? -17.57391 -41.88366 30.24236  1.000 52.64630 ? 155 ASP A OD1 1 
ATOM   1187 O OD2 . ASP A 1 155 ? -16.92783 -43.96571 30.46721  1.000 61.25283 ? 155 ASP A OD2 1 
ATOM   1188 N N   . CYS A 1 156 ? -17.08452 -39.97603 27.57031  1.000 40.55807 ? 156 CYS A N   1 
ATOM   1189 C CA  . CYS A 1 156 ? -18.03197 -39.89479 26.46558  1.000 38.44721 ? 156 CYS A CA  1 
ATOM   1190 C C   . CYS A 1 156 ? -17.68968 -38.71718 25.56184  1.000 34.09498 ? 156 CYS A C   1 
ATOM   1191 O O   . CYS A 1 156 ? -17.69376 -37.56332 26.00440  1.000 38.07685 ? 156 CYS A O   1 
ATOM   1192 C CB  . CYS A 1 156 ? -19.46273 -39.76843 26.97421  1.000 38.68416 ? 156 CYS A CB  1 
ATOM   1193 S SG  . CYS A 1 156 ? -20.65506 -39.78071 25.63329  1.000 44.13139 ? 156 CYS A SG  1 
ATOM   1194 N N   . VAL A 1 157 ? -17.41120 -39.01668 24.29705  1.000 36.88885 ? 157 VAL A N   1 
ATOM   1195 C CA  . VAL A 1 157 ? -17.13523 -38.00375 23.28036  1.000 30.85564 ? 157 VAL A CA  1 
ATOM   1196 C C   . VAL A 1 157 ? -18.45630 -37.57418 22.65583  1.000 30.45699 ? 157 VAL A C   1 
ATOM   1197 O O   . VAL A 1 157 ? -19.18037 -38.39555 22.08409  1.000 32.89308 ? 157 VAL A O   1 
ATOM   1198 C CB  . VAL A 1 157 ? -16.17364 -38.55156 22.21484  1.000 27.91547 ? 157 VAL A CB  1 
ATOM   1199 C CG1 . VAL A 1 157 ? -15.91656 -37.52003 21.12414  1.000 26.88489 ? 157 VAL A CG1 1 
ATOM   1200 C CG2 . VAL A 1 157 ? -14.87785 -38.99997 22.86540  1.000 27.92506 ? 157 VAL A CG2 1 
ATOM   1201 N N   . SER A 1 158 ? -18.78533 -36.29948 22.77762  1.000 29.83034 ? 158 SER A N   1 
ATOM   1202 C CA  . SER A 1 158 ? -19.93803 -35.72878 22.09146  1.000 32.62126 ? 158 SER A CA  1 
ATOM   1203 C C   . SER A 1 158 ? -19.43431 -35.03890 20.83460  1.000 28.49804 ? 158 SER A C   1 
ATOM   1204 O O   . SER A 1 158 ? -18.79678 -33.98461 20.91422  1.000 26.07459 ? 158 SER A O   1 
ATOM   1205 C CB  . SER A 1 158 ? -20.69192 -34.74787 22.98670  1.000 29.68878 ? 158 SER A CB  1 
ATOM   1206 O OG  . SER A 1 158 ? -21.35943 -35.44070 24.01784  1.000 32.32310 ? 158 SER A OG  1 
ATOM   1207 N N   . PHE A 1 159 ? -19.71545 -35.63309 19.68214  1.000 27.21898 ? 159 PHE A N   1 
ATOM   1208 C CA  . PHE A 1 159 ? -19.34526 -35.03906 18.40400  1.000 23.87762 ? 159 PHE A CA  1 
ATOM   1209 C C   . PHE A 1 159 ? -20.39237 -34.00959 18.00195  1.000 23.13811 ? 159 PHE A C   1 
ATOM   1210 O O   . PHE A 1 159 ? -21.59280 -34.29114 18.00832  1.000 24.52601 ? 159 PHE A O   1 
ATOM   1211 C CB  . PHE A 1 159 ? -19.22777 -36.11597 17.32661  1.000 22.37957 ? 159 PHE A CB  1 
ATOM   1212 C CG  . PHE A 1 159 ? -18.13438 -37.12323 17.58172  1.000 24.47726 ? 159 PHE A CG  1 
ATOM   1213 C CD1 . PHE A 1 159 ? -16.81065 -36.82028 17.28177  1.000 22.62382 ? 159 PHE A CD1 1 
ATOM   1214 C CD2 . PHE A 1 159 ? -18.43193 -38.38418 18.08648  1.000 22.50182 ? 159 PHE A CD2 1 
ATOM   1215 C CE1 . PHE A 1 159 ? -15.80489 -37.75462 17.49960  1.000 23.94378 ? 159 PHE A CE1 1 
ATOM   1216 C CE2 . PHE A 1 159 ? -17.42618 -39.33023 18.30797  1.000 21.64888 ? 159 PHE A CE2 1 
ATOM   1217 C CZ  . PHE A 1 159 ? -16.12045 -39.01900 18.00705  1.000 26.85647 ? 159 PHE A CZ  1 
ATOM   1218 N N   . CYS A 1 160 ? -19.94302 -32.81361 17.66245  1.000 24.24965 ? 160 CYS A N   1 
ATOM   1219 C CA  . CYS A 1 160 ? -20.86417 -31.73697 17.36204  1.000 27.06875 ? 160 CYS A CA  1 
ATOM   1220 C C   . CYS A 1 160 ? -20.64402 -31.07672 16.01491  1.000 25.76891 ? 160 CYS A C   1 
ATOM   1221 O O   . CYS A 1 160 ? -21.48807 -30.26909 15.61180  1.000 23.50549 ? 160 CYS A O   1 
ATOM   1222 C CB  . CYS A 1 160 ? -20.78728 -30.65960 18.45260  1.000 28.91943 ? 160 CYS A CB  1 
ATOM   1223 S SG  . CYS A 1 160 ? -19.17083 -29.89440 18.63686  1.000 28.31554 ? 160 CYS A SG  1 
ATOM   1224 N N   . TYR A 1 161 ? -19.54911 -31.37423 15.30962  1.000 21.74693 ? 161 TYR A N   1 
ATOM   1225 C CA  . TYR A 1 161 ? -19.20036 -30.62068 14.11427  1.000 22.60198 ? 161 TYR A CA  1 
ATOM   1226 C C   . TYR A 1 161 ? -18.40649 -31.50146 13.16637  1.000 20.24579 ? 161 TYR A C   1 
ATOM   1227 O O   . TYR A 1 161 ? -17.56941 -32.29516 13.60193  1.000 19.68541 ? 161 TYR A O   1 
ATOM   1228 C CB  . TYR A 1 161 ? -18.37203 -29.36865 14.47174  1.000 23.71860 ? 161 TYR A CB  1 
ATOM   1229 C CG  . TYR A 1 161 ? -17.95091 -28.55253 13.27228  1.000 25.49151 ? 161 TYR A CG  1 
ATOM   1230 C CD1 . TYR A 1 161 ? -18.80415 -27.61048 12.72107  1.000 23.58293 ? 161 TYR A CD1 1 
ATOM   1231 C CD2 . TYR A 1 161 ? -16.69898 -28.71666 12.69485  1.000 22.87710 ? 161 TYR A CD2 1 
ATOM   1232 C CE1 . TYR A 1 161 ? -18.42526 -26.85925 11.63082  1.000 20.10583 ? 161 TYR A CE1 1 
ATOM   1233 C CE2 . TYR A 1 161 ? -16.31262 -27.96279 11.59353  1.000 19.68835 ? 161 TYR A CE2 1 
ATOM   1234 C CZ  . TYR A 1 161 ? -17.17877 -27.04140 11.07380  1.000 23.51739 ? 161 TYR A CZ  1 
ATOM   1235 O OH  . TYR A 1 161 ? -16.80925 -26.28987 9.97365   1.000 23.52625 ? 161 TYR A OH  1 
ATOM   1236 N N   . MET A 1 162 ? -18.67005 -31.35131 11.87001  1.000 19.44178 ? 162 MET A N   1 
ATOM   1237 C CA  . MET A 1 162 ? -17.83787 -31.94893 10.83354  1.000 22.73620 ? 162 MET A CA  1 
ATOM   1238 C C   . MET A 1 162 ? -17.58535 -30.87750 9.78707   1.000 25.48570 ? 162 MET A C   1 
ATOM   1239 O O   . MET A 1 162 ? -18.51265 -30.17184 9.37741   1.000 19.84596 ? 162 MET A O   1 
ATOM   1240 C CB  . MET A 1 162 ? -18.50663 -33.18683 10.21818  1.000 21.70772 ? 162 MET A CB  1 
ATOM   1241 C CG  . MET A 1 162 ? -17.86251 -33.66794 8.92119   1.000 24.11872 ? 162 MET A CG  1 
ATOM   1242 S SD  . MET A 1 162 ? -18.44056 -35.29700 8.42042   1.000 27.50789 ? 162 MET A SD  1 
ATOM   1243 C CE  . MET A 1 162 ? -17.35798 -36.34158 9.37864   1.000 28.38075 ? 162 MET A CE  1 
ATOM   1244 N N   . HIS A 1 163 ? -16.33311 -30.71013 9.39135   1.000 23.04969 ? 163 HIS A N   1 
ATOM   1245 C CA  . HIS A 1 163 ? -16.00966 -29.59361 8.52343   1.000 22.70356 ? 163 HIS A CA  1 
ATOM   1246 C C   . HIS A 1 163 ? -16.37542 -29.91379 7.08377   1.000 20.95463 ? 163 HIS A C   1 
ATOM   1247 O O   . HIS A 1 163 ? -16.02222 -30.98406 6.58115   1.000 21.16577 ? 163 HIS A O   1 
ATOM   1248 C CB  . HIS A 1 163 ? -14.52704 -29.26057 8.62607   1.000 22.81145 ? 163 HIS A CB  1 
ATOM   1249 C CG  . HIS A 1 163 ? -14.12419 -28.13983 7.73612   1.000 24.39383 ? 163 HIS A CG  1 
ATOM   1250 N ND1 . HIS A 1 163 ? -14.59062 -26.85632 7.90741   1.000 22.54286 ? 163 HIS A ND1 1 
ATOM   1251 C CD2 . HIS A 1 163 ? -13.31962 -28.11005 6.64944   1.000 23.92556 ? 163 HIS A CD2 1 
ATOM   1252 C CE1 . HIS A 1 163 ? -14.08358 -26.08071 6.97010   1.000 28.58358 ? 163 HIS A CE1 1 
ATOM   1253 N NE2 . HIS A 1 163 ? -13.31130 -26.81720 6.19353   1.000 22.53463 ? 163 HIS A NE2 1 
ATOM   1254 N N   . HIS A 1 164 ? -17.07830 -28.98218 6.41962   1.000 22.62737 ? 164 HIS A N   1 
ATOM   1255 C CA  . HIS A 1 164 ? -17.44595 -29.12101 5.00826   1.000 21.08104 ? 164 HIS A CA  1 
ATOM   1256 C C   . HIS A 1 164 ? -16.89382 -28.01763 4.11978   1.000 23.44913 ? 164 HIS A C   1 
ATOM   1257 O O   . HIS A 1 164 ? -16.43944 -28.32194 3.01027   1.000 31.79088 ? 164 HIS A O   1 
ATOM   1258 C CB  . HIS A 1 164 ? -18.97292 -29.16472 4.80316   1.000 20.59674 ? 164 HIS A CB  1 
ATOM   1259 C CG  . HIS A 1 164 ? -19.63215 -30.40182 5.32995   1.000 17.74995 ? 164 HIS A CG  1 
ATOM   1260 N ND1 . HIS A 1 164 ? -20.37828 -31.24162 4.52989   1.000 24.69200 ? 164 HIS A ND1 1 
ATOM   1261 C CD2 . HIS A 1 164 ? -19.68070 -30.92636 6.57577   1.000 19.50861 ? 164 HIS A CD2 1 
ATOM   1262 C CE1 . HIS A 1 164 ? -20.84900 -32.23722 5.25844   1.000 23.70484 ? 164 HIS A CE1 1 
ATOM   1263 N NE2 . HIS A 1 164 ? -20.44448 -32.06816 6.50701   1.000 25.86861 ? 164 HIS A NE2 1 
ATOM   1264 N N   . MET A 1 165 ? -16.94241 -26.74333 4.53612   1.000 23.72333 ? 165 MET A N   1 
ATOM   1265 C CA  . MET A 1 165 ? -16.73082 -25.63890 3.59585   1.000 24.30274 ? 165 MET A CA  1 
ATOM   1266 C C   . MET A 1 165 ? -15.83771 -24.53282 4.14911   1.000 28.29355 ? 165 MET A C   1 
ATOM   1267 O O   . MET A 1 165 ? -15.89021 -24.18788 5.33730   1.000 24.93308 ? 165 MET A O   1 
ATOM   1268 C CB  . MET A 1 165 ? -18.05192 -24.96565 3.16933   1.000 26.31693 ? 165 MET A CB  1 
ATOM   1269 C CG  . MET A 1 165 ? -19.10145 -25.90237 2.61874   1.000 27.33298 ? 165 MET A CG  1 
ATOM   1270 S SD  . MET A 1 165 ? -18.73362 -26.55440 0.95257   1.000 37.61650 ? 165 MET A SD  1 
ATOM   1271 C CE  . MET A 1 165 ? -18.99665 -25.08725 -0.05638  1.000 36.91564 ? 165 MET A CE  1 
ATOM   1272 N N   . GLU A 1 166 ? -15.05960 -23.93090 3.23933   1.000 24.62295 ? 166 GLU A N   1 
ATOM   1273 C CA  . GLU A 1 166 ? -14.45813 -22.61856 3.44699   1.000 22.51565 ? 166 GLU A CA  1 
ATOM   1274 C C   . GLU A 1 166 ? -15.21217 -21.58286 2.61067   1.000 30.96515 ? 166 GLU A C   1 
ATOM   1275 O O   . GLU A 1 166 ? -15.26271 -21.68538 1.37866   1.000 29.10957 ? 166 GLU A O   1 
ATOM   1276 C CB  . GLU A 1 166 ? -12.98107 -22.62526 3.06426   1.000 26.66151 ? 166 GLU A CB  1 
ATOM   1277 C CG  . GLU A 1 166 ? -12.24907 -21.34585 3.46913   1.000 29.47979 ? 166 GLU A CG  1 
ATOM   1278 C CD  . GLU A 1 166 ? -10.73957 -21.49722 3.39391   1.000 39.25490 ? 166 GLU A CD  1 
ATOM   1279 O OE1 . GLU A 1 166 ? -10.21112 -21.69369 2.27027   1.000 43.06960 ? 166 GLU A OE1 1 
ATOM   1280 O OE2 . GLU A 1 166 ? -10.09158 -21.45594 4.46774   1.000 32.85948 ? 166 GLU A OE2 1 
ATOM   1281 N N   . LEU A 1 167 ? -15.79800 -20.59558 3.27827   1.000 29.59476 ? 167 LEU A N   1 
ATOM   1282 C CA  . LEU A 1 167 ? -16.44939 -19.49688 2.58982   1.000 24.81117 ? 167 LEU A CA  1 
ATOM   1283 C C   . LEU A 1 167 ? -15.40062 -18.57220 1.97573   1.000 28.33979 ? 167 LEU A C   1 
ATOM   1284 O O   . LEU A 1 167 ? -14.25244 -18.53991 2.42371   1.000 30.61126 ? 167 LEU A O   1 
ATOM   1285 C CB  . LEU A 1 167 ? -17.33513 -18.72777 3.56546   1.000 34.24733 ? 167 LEU A CB  1 
ATOM   1286 C CG  . LEU A 1 167 ? -18.27035 -19.62538 4.38874   1.000 34.63160 ? 167 LEU A CG  1 
ATOM   1287 C CD1 . LEU A 1 167 ? -19.23596 -18.79479 5.20779   1.000 38.71329 ? 167 LEU A CD1 1 
ATOM   1288 C CD2 . LEU A 1 167 ? -19.01775 -20.59611 3.49404   1.000 35.33306 ? 167 LEU A CD2 1 
ATOM   1289 N N   . PRO A 1 168 ? -15.77624 -17.80260 0.94977   1.000 32.57645 ? 168 PRO A N   1 
ATOM   1290 C CA  . PRO A 1 168 ? -14.82479 -16.85208 0.34933   1.000 34.43121 ? 168 PRO A CA  1 
ATOM   1291 C C   . PRO A 1 168 ? -14.20903 -15.86620 1.32230   1.000 33.36433 ? 168 PRO A C   1 
ATOM   1292 O O   . PRO A 1 168 ? -13.15175 -15.30248 1.02197   1.000 37.55520 ? 168 PRO A O   1 
ATOM   1293 C CB  . PRO A 1 168 ? -15.67866 -16.13505 -0.69827  1.000 37.74097 ? 168 PRO A CB  1 
ATOM   1294 C CG  . PRO A 1 168 ? -16.68362 -17.16366 -1.08807  1.000 37.29196 ? 168 PRO A CG  1 
ATOM   1295 C CD  . PRO A 1 168 ? -17.02009 -17.89768 0.17086   1.000 35.64148 ? 168 PRO A CD  1 
ATOM   1296 N N   . THR A 1 169 ? -14.82778 -15.62775 2.46648   1.000 35.32209 ? 169 THR A N   1 
ATOM   1297 C CA  . THR A 1 169 ? -14.25405 -14.75697 3.48061   1.000 38.94409 ? 169 THR A CA  1 
ATOM   1298 C C   . THR A 1 169 ? -13.26943 -15.48131 4.38432   1.000 30.00187 ? 169 THR A C   1 
ATOM   1299 O O   . THR A 1 169 ? -12.73534 -14.86815 5.30875   1.000 38.53041 ? 169 THR A O   1 
ATOM   1300 C CB  . THR A 1 169 ? -15.36743 -14.13192 4.32458   1.000 34.06823 ? 169 THR A CB  1 
ATOM   1301 O OG1 . THR A 1 169 ? -16.22394 -15.16576 4.81223   1.000 33.59670 ? 169 THR A OG1 1 
ATOM   1302 C CG2 . THR A 1 169 ? -16.18783 -13.15548 3.47700   1.000 42.41672 ? 169 THR A CG2 1 
ATOM   1303 N N   . GLY A 1 170 ? -13.00301 -16.75828 4.13790   1.000 31.10110 ? 170 GLY A N   1 
ATOM   1304 C CA  . GLY A 1 170 ? -11.99912 -17.44879 4.91102   1.000 31.82206 ? 170 GLY A CA  1 
ATOM   1305 C C   . GLY A 1 170 ? -12.47556 -18.03487 6.21424   1.000 32.97955 ? 170 GLY A C   1 
ATOM   1306 O O   . GLY A 1 170 ? -11.66705 -18.64350 6.92843   1.000 33.25964 ? 170 GLY A O   1 
ATOM   1307 N N   . VAL A 1 171 ? -13.74865 -17.86206 6.56233   1.000 34.75009 ? 171 VAL A N   1 
ATOM   1308 C CA  . VAL A 1 171 ? -14.30686 -18.53072 7.72646   1.000 28.21084 ? 171 VAL A CA  1 
ATOM   1309 C C   . VAL A 1 171 ? -14.87858 -19.85559 7.24863   1.000 26.44961 ? 171 VAL A C   1 
ATOM   1310 O O   . VAL A 1 171 ? -14.89475 -20.14681 6.04484   1.000 29.03785 ? 171 VAL A O   1 
ATOM   1311 C CB  . VAL A 1 171 ? -15.37792 -17.67565 8.42365   1.000 29.48175 ? 171 VAL A CB  1 
ATOM   1312 C CG1 . VAL A 1 171 ? -14.76573 -16.38167 8.94068   1.000 34.45291 ? 171 VAL A CG1 1 
ATOM   1313 C CG2 . VAL A 1 171 ? -16.52856 -17.40676 7.47580   1.000 22.52147 ? 171 VAL A CG2 1 
ATOM   1314 N N   . HIS A 1 172 ? -15.37124 -20.65556 8.18182   1.000 23.14905 ? 172 HIS A N   1 
ATOM   1315 C CA  . HIS A 1 172 ? -15.61885 -22.05894 7.92202   1.000 23.86734 ? 172 HIS A CA  1 
ATOM   1316 C C   . HIS A 1 172 ? -17.03909 -22.42705 8.31902   1.000 28.01819 ? 172 HIS A C   1 
ATOM   1317 O O   . HIS A 1 172 ? -17.59819 -21.87348 9.27038   1.000 23.06222 ? 172 HIS A O   1 
ATOM   1318 C CB  . HIS A 1 172 ? -14.58492 -22.90850 8.66549   1.000 22.56126 ? 172 HIS A CB  1 
ATOM   1319 C CG  . HIS A 1 172 ? -13.16877 -22.54034 8.33538   1.000 25.56455 ? 172 HIS A CG  1 
ATOM   1320 N ND1 . HIS A 1 172 ? -12.34949 -21.86441 9.21324   1.000 25.54767 ? 172 HIS A ND1 1 
ATOM   1321 C CD2 . HIS A 1 172 ? -12.43816 -22.72897 7.20654   1.000 27.99653 ? 172 HIS A CD2 1 
ATOM   1322 C CE1 . HIS A 1 172 ? -11.16954 -21.66630 8.64537   1.000 30.67611 ? 172 HIS A CE1 1 
ATOM   1323 N NE2 . HIS A 1 172 ? -11.19746 -22.17989 7.42719   1.000 24.69637 ? 172 HIS A NE2 1 
ATOM   1324 N N   . ALA A 1 173 ? -17.61435 -23.36928 7.56757   1.000 25.18282 ? 173 ALA A N   1 
ATOM   1325 C CA  . ALA A 1 173 ? -18.97548 -23.83703 7.77641   1.000 22.98908 ? 173 ALA A CA  1 
ATOM   1326 C C   . ALA A 1 173 ? -18.99721 -25.35514 7.72608   1.000 23.72483 ? 173 ALA A C   1 
ATOM   1327 O O   . ALA A 1 173 ? -18.20568 -25.98422 7.01646   1.000 21.86326 ? 173 ALA A O   1 
ATOM   1328 C CB  . ALA A 1 173 ? -19.94135 -23.28442 6.72416   1.000 20.31555 ? 173 ALA A CB  1 
ATOM   1329 N N   . GLY A 1 174 ? -19.92401 -25.94425 8.46658   1.000 20.66005 ? 174 GLY A N   1 
ATOM   1330 C CA  . GLY A 1 174 ? -20.00192 -27.38248 8.48376   1.000 16.94685 ? 174 GLY A CA  1 
ATOM   1331 C C   . GLY A 1 174 ? -21.29329 -27.84543 9.11154   1.000 24.05097 ? 174 GLY A C   1 
ATOM   1332 O O   . GLY A 1 174 ? -22.22173 -27.05869 9.31839   1.000 23.89893 ? 174 GLY A O   1 
ATOM   1333 N N   . THR A 1 175 ? -21.35256 -29.14404 9.38502   1.000 21.76440 ? 175 THR A N   1 
ATOM   1334 C CA  . THR A 1 175 ? -22.59432 -29.77587 9.80378   1.000 20.96197 ? 175 THR A CA  1 
ATOM   1335 C C   . THR A 1 175 ? -22.43944 -30.38073 11.19155  1.000 26.40828 ? 175 THR A C   1 
ATOM   1336 O O   . THR A 1 175 ? -21.33299 -30.52581 11.71944  1.000 21.47542 ? 175 THR A O   1 
ATOM   1337 C CB  . THR A 1 175 ? -23.03765 -30.88104 8.82896   1.000 20.81562 ? 175 THR A CB  1 
ATOM   1338 O OG1 . THR A 1 175 ? -22.12364 -31.98026 8.88903   1.000 22.30810 ? 175 THR A OG1 1 
ATOM   1339 C CG2 . THR A 1 175 ? -23.11668 -30.37248 7.39061   1.000 18.69610 ? 175 THR A CG2 1 
ATOM   1340 N N   . ASP A 1 176 ? -23.57458 -30.75659 11.77445  1.000 23.07742 ? 176 ASP A N   1 
ATOM   1341 C CA  . ASP A 1 176 ? -23.52412 -31.69412 12.88326  1.000 23.46625 ? 176 ASP A CA  1 
ATOM   1342 C C   . ASP A 1 176 ? -23.31858 -33.10740 12.32097  1.000 21.58652 ? 176 ASP A C   1 
ATOM   1343 O O   . ASP A 1 176 ? -23.22197 -33.31196 11.10402  1.000 23.69551 ? 176 ASP A O   1 
ATOM   1344 C CB  . ASP A 1 176 ? -24.78029 -31.55325 13.75859  1.000 25.97146 ? 176 ASP A CB  1 
ATOM   1345 C CG  . ASP A 1 176 ? -26.08000 -31.90069 13.02916  1.000 30.62817 ? 176 ASP A CG  1 
ATOM   1346 O OD1 . ASP A 1 176 ? -26.07750 -32.65448 12.03112  1.000 25.16144 ? 176 ASP A OD1 1 
ATOM   1347 O OD2 . ASP A 1 176 ? -27.13735 -31.41800 13.48636  1.000 29.63380 ? 176 ASP A OD2 1 
ATOM   1348 N N   . LEU A 1 177 ? -23.25521 -34.10799 13.19266  1.000 18.82513 ? 177 LEU A N   1 
ATOM   1349 C CA  . LEU A 1 177 ? -22.99801 -35.45104 12.67203  1.000 29.12131 ? 177 LEU A CA  1 
ATOM   1350 C C   . LEU A 1 177 ? -24.23714 -36.11329 12.07072  1.000 32.01305 ? 177 LEU A C   1 
ATOM   1351 O O   . LEU A 1 177 ? -24.14298 -37.24902 11.57906  1.000 29.41595 ? 177 LEU A O   1 
ATOM   1352 C CB  . LEU A 1 177 ? -22.37749 -36.33951 13.75760  1.000 24.44940 ? 177 LEU A CB  1 
ATOM   1353 C CG  . LEU A 1 177 ? -20.84698 -36.37058 13.69877  1.000 29.78654 ? 177 LEU A CG  1 
ATOM   1354 C CD1 . LEU A 1 177 ? -20.36650 -36.75793 12.29741  1.000 25.66864 ? 177 LEU A CD1 1 
ATOM   1355 C CD2 . LEU A 1 177 ? -20.25612 -35.02428 14.10271  1.000 29.44943 ? 177 LEU A CD2 1 
ATOM   1356 N N   . GLU A 1 178 ? -25.38488 -35.43737 12.06968  1.000 26.30392 ? 178 GLU A N   1 
ATOM   1357 C CA  . GLU A 1 178 ? -26.50048 -35.87714 11.24458  1.000 29.30026 ? 178 GLU A CA  1 
ATOM   1358 C C   . GLU A 1 178 ? -26.47846 -35.23257 9.86350   1.000 26.69716 ? 178 GLU A C   1 
ATOM   1359 O O   . GLU A 1 178 ? -27.33909 -35.53454 9.03017   1.000 29.82690 ? 178 GLU A O   1 
ATOM   1360 C CB  . GLU A 1 178 ? -27.82867 -35.59565 11.95841  1.000 33.22623 ? 178 GLU A CB  1 
ATOM   1361 C CG  . GLU A 1 178 ? -27.98724 -36.41116 13.23143  1.000 32.48866 ? 178 GLU A CG  1 
ATOM   1362 C CD  . GLU A 1 178 ? -29.20022 -36.01386 14.05947  1.000 46.88059 ? 178 GLU A CD  1 
ATOM   1363 O OE1 . GLU A 1 178 ? -29.99780 -35.16248 13.60906  1.000 42.04722 ? 178 GLU A OE1 1 
ATOM   1364 O OE2 . GLU A 1 178 ? -29.35034 -36.55825 15.17124  1.000 50.16896 ? 178 GLU A OE2 1 
ATOM   1365 N N   . GLY A 1 179 ? -25.50473 -34.36501 9.59503   1.000 28.65541 ? 179 GLY A N   1 
ATOM   1366 C CA  . GLY A 1 179 ? -25.34440 -33.79419 8.27559   1.000 24.25391 ? 179 GLY A CA  1 
ATOM   1367 C C   . GLY A 1 179 ? -26.16170 -32.55893 8.01711   1.000 24.07842 ? 179 GLY A C   1 
ATOM   1368 O O   . GLY A 1 179 ? -26.28263 -32.15075 6.85835   1.000 28.43007 ? 179 GLY A O   1 
ATOM   1369 N N   . ASN A 1 180 ? -26.75566 -31.96661 9.04847   1.000 22.49781 ? 180 ASN A N   1 
ATOM   1370 C CA  . ASN A 1 180 ? -27.41380 -30.67359 8.91209   1.000 23.92367 ? 180 ASN A CA  1 
ATOM   1371 C C   . ASN A 1 180 ? -26.40607 -29.55364 9.13471   1.000 25.30814 ? 180 ASN A C   1 
ATOM   1372 O O   . ASN A 1 180 ? -25.74864 -29.50310 10.18025  1.000 24.26607 ? 180 ASN A O   1 
ATOM   1373 C CB  . ASN A 1 180 ? -28.55453 -30.55208 9.91837   1.000 24.58001 ? 180 ASN A CB  1 
ATOM   1374 C CG  . ASN A 1 180 ? -29.54159 -31.69570 9.80909   1.000 31.19052 ? 180 ASN A CG  1 
ATOM   1375 O OD1 . ASN A 1 180 ? -30.17521 -31.87617 8.77531   1.000 31.58094 ? 180 ASN A OD1 1 
ATOM   1376 N ND2 . ASN A 1 180 ? -29.66393 -32.48053 10.86967  1.000 32.48448 ? 180 ASN A ND2 1 
ATOM   1377 N N   . PHE A 1 181 ? -26.31109 -28.63601 8.17562   1.000 21.47405 ? 181 PHE A N   1 
ATOM   1378 C CA  . PHE A 1 181 ? -25.42471 -27.50116 8.38491   1.000 23.66314 ? 181 PHE A CA  1 
ATOM   1379 C C   . PHE A 1 181 ? -25.85830 -26.68411 9.59532   1.000 28.00383 ? 181 PHE A C   1 
ATOM   1380 O O   . PHE A 1 181 ? -27.04325 -26.57464 9.92813   1.000 21.86879 ? 181 PHE A O   1 
ATOM   1381 C CB  . PHE A 1 181 ? -25.36064 -26.60337 7.14791   1.000 24.27621 ? 181 PHE A CB  1 
ATOM   1382 C CG  . PHE A 1 181 ? -24.25839 -26.98087 6.17654   1.000 27.13520 ? 181 PHE A CG  1 
ATOM   1383 C CD1 . PHE A 1 181 ? -24.46743 -27.95858 5.21484   1.000 25.82613 ? 181 PHE A CD1 1 
ATOM   1384 C CD2 . PHE A 1 181 ? -23.01881 -26.35919 6.23584   1.000 22.97657 ? 181 PHE A CD2 1 
ATOM   1385 C CE1 . PHE A 1 181 ? -23.47251 -28.30617 4.32550   1.000 23.18384 ? 181 PHE A CE1 1 
ATOM   1386 C CE2 . PHE A 1 181 ? -21.99990 -26.70880 5.35364   1.000 21.14302 ? 181 PHE A CE2 1 
ATOM   1387 C CZ  . PHE A 1 181 ? -22.22535 -27.68469 4.39511   1.000 24.08413 ? 181 PHE A CZ  1 
ATOM   1388 N N   . TYR A 1 182 ? -24.86581 -26.15010 10.28298  1.000 22.46530 ? 182 TYR A N   1 
ATOM   1389 C CA  . TYR A 1 182 ? -25.08790 -25.02752 11.16742  1.000 25.63735 ? 182 TYR A CA  1 
ATOM   1390 C C   . TYR A 1 182 ? -25.28801 -23.77561 10.32592  1.000 25.59408 ? 182 TYR A C   1 
ATOM   1391 O O   . TYR A 1 182 ? -24.52704 -23.51388 9.38558   1.000 23.95868 ? 182 TYR A O   1 
ATOM   1392 C CB  . TYR A 1 182 ? -23.90571 -24.88197 12.12011  1.000 24.83475 ? 182 TYR A CB  1 
ATOM   1393 C CG  . TYR A 1 182 ? -23.79846 -26.00388 13.13252  1.000 19.71672 ? 182 TYR A CG  1 
ATOM   1394 C CD1 . TYR A 1 182 ? -24.53861 -25.96364 14.30837  1.000 22.81029 ? 182 TYR A CD1 1 
ATOM   1395 C CD2 . TYR A 1 182 ? -22.94604 -27.08529 12.93483  1.000 22.25117 ? 182 TYR A CD2 1 
ATOM   1396 C CE1 . TYR A 1 182 ? -24.44725 -26.95629 15.24900  1.000 24.47557 ? 182 TYR A CE1 1 
ATOM   1397 C CE2 . TYR A 1 182 ? -22.83946 -28.10100 13.88169  1.000 20.63598 ? 182 TYR A CE2 1 
ATOM   1398 C CZ  . TYR A 1 182 ? -23.60555 -28.02741 15.04442  1.000 25.53241 ? 182 TYR A CZ  1 
ATOM   1399 O OH  . TYR A 1 182 ? -23.54519 -29.00377 16.01130  1.000 21.99052 ? 182 TYR A OH  1 
ATOM   1400 N N   . GLY A 1 183 ? -26.32901 -23.01495 10.63712  1.000 24.16571 ? 183 GLY A N   1 
ATOM   1401 C CA  . GLY A 1 183 ? -26.64348 -21.82606 9.88027   1.000 22.64714 ? 183 GLY A CA  1 
ATOM   1402 C C   . GLY A 1 183 ? -27.22333 -22.08184 8.50242   1.000 27.17120 ? 183 GLY A C   1 
ATOM   1403 O O   . GLY A 1 183 ? -27.65182 -23.19042 8.16758   1.000 25.26002 ? 183 GLY A O   1 
ATOM   1404 N N   . PRO A 1 184 ? -27.24933 -21.04159 7.66846   1.000 28.06483 ? 184 PRO A N   1 
ATOM   1405 C CA  . PRO A 1 184 ? -27.88419 -21.13781 6.34460   1.000 29.25602 ? 184 PRO A CA  1 
ATOM   1406 C C   . PRO A 1 184 ? -26.99545 -21.71287 5.25234   1.000 31.80921 ? 184 PRO A C   1 
ATOM   1407 O O   . PRO A 1 184 ? -27.35138 -21.61749 4.07582   1.000 28.44409 ? 184 PRO A O   1 
ATOM   1408 C CB  . PRO A 1 184 ? -28.19201 -19.66680 6.04411   1.000 26.75426 ? 184 PRO A CB  1 
ATOM   1409 C CG  . PRO A 1 184 ? -27.01702 -18.96274 6.62830   1.000 29.64870 ? 184 PRO A CG  1 
ATOM   1410 C CD  . PRO A 1 184 ? -26.62843 -19.72294 7.87801   1.000 24.71781 ? 184 PRO A CD  1 
ATOM   1411 N N   . PHE A 1 185 ? -25.86115 -22.29526 5.59363   1.000 29.77960 ? 185 PHE A N   1 
ATOM   1412 C CA  . PHE A 1 185 ? -24.89542 -22.59558 4.55586   1.000 29.83355 ? 185 PHE A CA  1 
ATOM   1413 C C   . PHE A 1 185 ? -25.22965 -23.91850 3.86692   1.000 26.04168 ? 185 PHE A C   1 
ATOM   1414 O O   . PHE A 1 185 ? -25.99901 -24.74589 4.36775   1.000 24.47712 ? 185 PHE A O   1 
ATOM   1415 C CB  . PHE A 1 185 ? -23.50168 -22.57978 5.16453   1.000 27.20922 ? 185 PHE A CB  1 
ATOM   1416 C CG  . PHE A 1 185 ? -23.19061 -21.28548 5.86618   1.000 25.40513 ? 185 PHE A CG  1 
ATOM   1417 C CD1 . PHE A 1 185 ? -23.03129 -20.11715 5.14395   1.000 28.11372 ? 185 PHE A CD1 1 
ATOM   1418 C CD2 . PHE A 1 185 ? -23.07889 -21.23351 7.24605   1.000 27.08965 ? 185 PHE A CD2 1 
ATOM   1419 C CE1 . PHE A 1 185 ? -22.75444 -18.91567 5.78571   1.000 35.77857 ? 185 PHE A CE1 1 
ATOM   1420 C CE2 . PHE A 1 185 ? -22.79940 -20.03549 7.88640   1.000 24.50884 ? 185 PHE A CE2 1 
ATOM   1421 C CZ  . PHE A 1 185 ? -22.63632 -18.87961 7.15359   1.000 32.10517 ? 185 PHE A CZ  1 
ATOM   1422 N N   . VAL A 1 186 ? -24.66669 -24.09453 2.67306   1.000 29.78510 ? 186 VAL A N   1 
ATOM   1423 C CA  . VAL A 1 186 ? -24.93384 -25.26769 1.84914   1.000 28.45613 ? 186 VAL A CA  1 
ATOM   1424 C C   . VAL A 1 186 ? -23.61976 -25.73707 1.24068   1.000 26.75548 ? 186 VAL A C   1 
ATOM   1425 O O   . VAL A 1 186 ? -22.65087 -24.97941 1.15788   1.000 25.03679 ? 186 VAL A O   1 
ATOM   1426 C CB  . VAL A 1 186 ? -25.97324 -24.97347 0.74681   1.000 30.99290 ? 186 VAL A CB  1 
ATOM   1427 C CG1 . VAL A 1 186 ? -27.27185 -24.45512 1.36364   1.000 32.15474 ? 186 VAL A CG1 1 
ATOM   1428 C CG2 . VAL A 1 186 ? -25.42730 -23.98264 -0.25984  1.000 30.75474 ? 186 VAL A CG2 1 
ATOM   1429 N N   . ASP A 1 187 ? -23.57954 -27.01431 0.83476   1.000 22.04156 ? 187 ASP A N   1 
ATOM   1430 C CA  . ASP A 1 187 ? -22.35022 -27.57774 0.27599   1.000 24.38166 ? 187 ASP A CA  1 
ATOM   1431 C C   . ASP A 1 187 ? -22.34827 -27.37825 -1.24101  1.000 24.90224 ? 187 ASP A C   1 
ATOM   1432 O O   . ASP A 1 187 ? -22.42688 -28.30461 -2.04530  1.000 27.55809 ? 187 ASP A O   1 
ATOM   1433 C CB  . ASP A 1 187 ? -22.14997 -29.03792 0.69008   1.000 21.68464 ? 187 ASP A CB  1 
ATOM   1434 C CG  . ASP A 1 187 ? -23.39592 -29.90910 0.54670   1.000 26.22316 ? 187 ASP A CG  1 
ATOM   1435 O OD1 . ASP A 1 187 ? -24.49686 -29.41810 0.16259   1.000 25.35445 ? 187 ASP A OD1 1 
ATOM   1436 O OD2 . ASP A 1 187 ? -23.25886 -31.11402 0.86094   1.000 22.87888 ? 187 ASP A OD2 1 
ATOM   1437 N N   . ARG A 1 188 ? -22.21771 -26.10821 -1.61070  1.000 25.89263 ? 188 ARG A N   1 
ATOM   1438 C CA  . ARG A 1 188 ? -22.07671 -25.68435 -2.99052  1.000 32.92501 ? 188 ARG A CA  1 
ATOM   1439 C C   . ARG A 1 188 ? -21.08143 -24.53680 -3.01632  1.000 30.56259 ? 188 ARG A C   1 
ATOM   1440 O O   . ARG A 1 188 ? -21.03868 -23.73502 -2.08124  1.000 32.14874 ? 188 ARG A O   1 
ATOM   1441 C CB  . ARG A 1 188 ? -23.42641 -25.25096 -3.56936  1.000 31.94265 ? 188 ARG A CB  1 
ATOM   1442 C CG  . ARG A 1 188 ? -23.35562 -24.76861 -4.98744  1.000 37.29996 ? 188 ARG A CG  1 
ATOM   1443 C CD  . ARG A 1 188 ? -24.71608 -24.35100 -5.46686  1.000 44.86833 ? 188 ARG A CD  1 
ATOM   1444 N NE  . ARG A 1 188 ? -24.63629 -23.77651 -6.80054  1.000 44.27097 ? 188 ARG A NE  1 
ATOM   1445 C CZ  . ARG A 1 188 ? -25.66906 -23.24713 -7.43593  1.000 53.08337 ? 188 ARG A CZ  1 
ATOM   1446 N NH1 . ARG A 1 188 ? -26.87192 -23.21188 -6.88370  1.000 51.10606 ? 188 ARG A NH1 1 
ATOM   1447 N NH2 . ARG A 1 188 ? -25.48958 -22.73845 -8.65211  1.000 54.61655 ? 188 ARG A NH2 1 
ATOM   1448 N N   . GLN A 1 189 ? -20.27441 -24.46729 -4.07687  1.000 33.75487 ? 189 GLN A N   1 
ATOM   1449 C CA  . GLN A 1 189 ? -19.26336 -23.41848 -4.21004  1.000 30.45079 ? 189 GLN A CA  1 
ATOM   1450 C C   . GLN A 1 189 ? -19.92727 -22.21345 -4.86580  1.000 36.71738 ? 189 GLN A C   1 
ATOM   1451 O O   . GLN A 1 189 ? -19.82263 -21.96943 -6.06976  1.000 34.32818 ? 189 GLN A O   1 
ATOM   1452 C CB  . GLN A 1 189 ? -18.06196 -23.90941 -5.00992  1.000 30.92026 ? 189 GLN A CB  1 
ATOM   1453 C CG  . GLN A 1 189 ? -16.96381 -22.87247 -5.11821  1.000 37.89142 ? 189 GLN A CG  1 
ATOM   1454 C CD  . GLN A 1 189 ? -15.84697 -23.30812 -6.03541  1.000 45.65852 ? 189 GLN A CD  1 
ATOM   1455 O OE1 . GLN A 1 189 ? -15.56057 -24.50294 -6.16381  1.000 49.22094 ? 189 GLN A OE1 1 
ATOM   1456 N NE2 . GLN A 1 189 ? -15.20891 -22.34412 -6.68632  1.000 43.52310 ? 189 GLN A NE2 1 
ATOM   1457 N N   . THR A 1 190 ? -20.63863 -21.45386 -4.04116  1.000 37.07226 ? 190 THR A N   1 
ATOM   1458 C CA  . THR A 1 190 ? -21.32706 -20.25052 -4.46807  1.000 42.55909 ? 190 THR A CA  1 
ATOM   1459 C C   . THR A 1 190 ? -21.06623 -19.16407 -3.44023  1.000 37.69187 ? 190 THR A C   1 
ATOM   1460 O O   . THR A 1 190 ? -20.47896 -19.40986 -2.38339  1.000 39.92487 ? 190 THR A O   1 
ATOM   1461 C CB  . THR A 1 190 ? -22.83205 -20.48767 -4.61550  1.000 43.93515 ? 190 THR A CB  1 
ATOM   1462 O OG1 . THR A 1 190 ? -23.47659 -19.24596 -4.91119  1.000 51.05264 ? 190 THR A OG1 1 
ATOM   1463 C CG2 . THR A 1 190 ? -23.39447 -21.05160 -3.31843  1.000 39.03071 ? 190 THR A CG2 1 
ATOM   1464 N N   . ALA A 1 191 ? -21.51727 -17.95278 -3.75802  1.000 45.53820 ? 191 ALA A N   1 
ATOM   1465 C CA  . ALA A 1 191 ? -21.43502 -16.84651 -2.81285  1.000 46.20127 ? 191 ALA A CA  1 
ATOM   1466 C C   . ALA A 1 191 ? -22.29389 -17.15774 -1.59620  1.000 42.69436 ? 191 ALA A C   1 
ATOM   1467 O O   . ALA A 1 191 ? -23.49874 -17.39625 -1.72037  1.000 44.98936 ? 191 ALA A O   1 
ATOM   1468 C CB  . ALA A 1 191 ? -21.88742 -15.54632 -3.47263  1.000 49.17924 ? 191 ALA A CB  1 
ATOM   1469 N N   . GLN A 1 192 ? -21.66944 -17.19507 -0.42687  1.000 41.06912 ? 192 GLN A N   1 
ATOM   1470 C CA  . GLN A 1 192 ? -22.37402 -17.38349 0.83416   1.000 39.49517 ? 192 GLN A CA  1 
ATOM   1471 C C   . GLN A 1 192 ? -21.78932 -16.38731 1.81609   1.000 48.27798 ? 192 GLN A C   1 
ATOM   1472 O O   . GLN A 1 192 ? -20.60969 -16.48188 2.17182   1.000 50.78015 ? 192 GLN A O   1 
ATOM   1473 C CB  . GLN A 1 192 ? -22.22469 -18.80874 1.35538   1.000 37.21370 ? 192 GLN A CB  1 
ATOM   1474 C CG  . GLN A 1 192 ? -22.36096 -19.85997 0.29198   1.000 42.74304 ? 192 GLN A CG  1 
ATOM   1475 C CD  . GLN A 1 192 ? -22.53609 -21.22921 0.87740   1.000 39.40047 ? 192 GLN A CD  1 
ATOM   1476 O OE1 . GLN A 1 192 ? -23.46081 -21.45965 1.65789   1.000 26.91538 ? 192 GLN A OE1 1 
ATOM   1477 N NE2 . GLN A 1 192 ? -21.64871 -22.15174 0.51257   1.000 31.04932 ? 192 GLN A NE2 1 
ATOM   1478 N N   . ALA A 1 193 ? -22.59090 -15.42120 2.22651   1.000 40.16342 ? 193 ALA A N   1 
ATOM   1479 C CA  . ALA A 1 193 ? -22.13553 -14.44548 3.19972   1.000 49.42529 ? 193 ALA A CA  1 
ATOM   1480 C C   . ALA A 1 193 ? -22.60796 -14.85707 4.58808   1.000 42.56698 ? 193 ALA A C   1 
ATOM   1481 O O   . ALA A 1 193 ? -23.67314 -15.45810 4.75198   1.000 46.49188 ? 193 ALA A O   1 
ATOM   1482 C CB  . ALA A 1 193 ? -22.63215 -13.04502 2.84610   1.000 51.20234 ? 193 ALA A CB  1 
ATOM   1483 N N   . ALA A 1 194 ? -21.79181 -14.53644 5.59161   1.000 48.09335 ? 194 ALA A N   1 
ATOM   1484 C CA  . ALA A 1 194 ? -21.98827 -15.10504 6.92171   1.000 42.23420 ? 194 ALA A CA  1 
ATOM   1485 C C   . ALA A 1 194 ? -23.13305 -14.43463 7.67714   1.000 45.94339 ? 194 ALA A C   1 
ATOM   1486 O O   . ALA A 1 194 ? -24.09261 -15.09799 8.09185   1.000 60.98855 ? 194 ALA A O   1 
ATOM   1487 C CB  . ALA A 1 194 ? -20.68443 -15.00587 7.72419   1.000 39.12915 ? 194 ALA A CB  1 
ATOM   1488 N N   . GLY A 1 195 ? -23.04954 -13.12389 7.85603   1.000 35.22075 ? 195 GLY A N   1 
ATOM   1489 C CA  . GLY A 1 195 ? -23.84448 -12.39518 8.82393   1.000 37.56119 ? 195 GLY A CA  1 
ATOM   1490 C C   . GLY A 1 195 ? -22.96259 -11.75280 9.88357   1.000 34.55794 ? 195 GLY A C   1 
ATOM   1491 O O   . GLY A 1 195 ? -21.78265 -12.06124 10.01263  1.000 24.97892 ? 195 GLY A O   1 
ATOM   1492 N N   . THR A 1 196 ? -23.56666 -10.83197 10.64499  1.000 25.81827 ? 196 THR A N   1 
ATOM   1493 C CA  . THR A 1 196 ? -22.81596 -10.09677 11.66470  1.000 28.74828 ? 196 THR A CA  1 
ATOM   1494 C C   . THR A 1 196 ? -22.17892 -11.05846 12.66426  1.000 30.63978 ? 196 THR A C   1 
ATOM   1495 O O   . THR A 1 196 ? -22.87761 -11.85773 13.29236  1.000 29.99472 ? 196 THR A O   1 
ATOM   1496 C CB  . THR A 1 196 ? -23.72997 -9.11146  12.40629  1.000 29.30524 ? 196 THR A CB  1 
ATOM   1497 O OG1 . THR A 1 196 ? -24.33402 -8.21799  11.47186  1.000 22.42945 ? 196 THR A OG1 1 
ATOM   1498 C CG2 . THR A 1 196 ? -22.92781 -8.29434  13.42271  1.000 34.75973 ? 196 THR A CG2 1 
ATOM   1499 N N   . ASP A 1 197 ? -20.85268 -10.96999 12.82903  1.000 29.68941 ? 197 ASP A N   1 
ATOM   1500 C CA  . ASP A 1 197 ? -20.14591 -11.78950 13.82274  1.000 30.98544 ? 197 ASP A CA  1 
ATOM   1501 C C   . ASP A 1 197 ? -20.22009 -11.06387 15.16184  1.000 31.26004 ? 197 ASP A C   1 
ATOM   1502 O O   . ASP A 1 197 ? -19.34783 -10.26793 15.52553  1.000 34.55629 ? 197 ASP A O   1 
ATOM   1503 C CB  . ASP A 1 197 ? -18.70250 -12.05301 13.40658  1.000 34.63268 ? 197 ASP A CB  1 
ATOM   1504 C CG  . ASP A 1 197 ? -18.05272 -13.19918 14.19964  1.000 39.82164 ? 197 ASP A CG  1 
ATOM   1505 O OD1 . ASP A 1 197 ? -18.75155 -13.87325 14.99824  1.000 26.33352 ? 197 ASP A OD1 1 
ATOM   1506 O OD2 . ASP A 1 197 ? -16.83732 -13.43447 14.00933  1.000 42.39288 ? 197 ASP A OD2 1 
ATOM   1507 N N   . THR A 1 198 ? -21.28265 -11.32751 15.90161  1.000 29.11053 ? 198 THR A N   1 
ATOM   1508 C CA  . THR A 1 198 ? -21.42034 -10.66809 17.18420  1.000 25.71353 ? 198 THR A CA  1 
ATOM   1509 C C   . THR A 1 198 ? -20.57611 -11.39054 18.23131  1.000 27.10152 ? 198 THR A C   1 
ATOM   1510 O O   . THR A 1 198 ? -20.18168 -12.54704 18.05564  1.000 31.95156 ? 198 THR A O   1 
ATOM   1511 C CB  . THR A 1 198 ? -22.89478 -10.61629 17.58880  1.000 31.15478 ? 198 THR A CB  1 
ATOM   1512 O OG1 . THR A 1 198 ? -23.39840 -11.94577 17.71716  1.000 35.62640 ? 198 THR A OG1 1 
ATOM   1513 C CG2 . THR A 1 198 ? -23.71113 -9.90711  16.50656  1.000 29.98314 ? 198 THR A CG2 1 
ATOM   1514 N N   . THR A 1 199 ? -20.28748 -10.68769 19.32588  1.000 27.99111 ? 199 THR A N   1 
ATOM   1515 C CA  . THR A 1 199 ? -19.48156 -11.23302 20.41257  1.000 20.99239 ? 199 THR A CA  1 
ATOM   1516 C C   . THR A 1 199 ? -20.35914 -11.96978 21.42101  1.000 27.63593 ? 199 THR A C   1 
ATOM   1517 O O   . THR A 1 199 ? -21.47573 -11.53817 21.72078  1.000 25.71626 ? 199 THR A O   1 
ATOM   1518 C CB  . THR A 1 199 ? -18.70636 -10.11360 21.10231  1.000 27.58208 ? 199 THR A CB  1 
ATOM   1519 O OG1 . THR A 1 199 ? -17.88787 -9.45738  20.13165  1.000 30.11058 ? 199 THR A OG1 1 
ATOM   1520 C CG2 . THR A 1 199 ? -17.83509 -10.67033 22.20370  1.000 26.63612 ? 199 THR A CG2 1 
ATOM   1521 N N   . ILE A 1 200 ? -19.84313 -13.09024 21.94783  1.000 22.08209 ? 200 ILE A N   1 
ATOM   1522 C CA  . ILE A 1 200 ? -20.59064 -13.94424 22.86428  1.000 21.97975 ? 200 ILE A CA  1 
ATOM   1523 C C   . ILE A 1 200 ? -20.46213 -13.39308 24.28058  1.000 27.75846 ? 200 ILE A C   1 
ATOM   1524 O O   . ILE A 1 200 ? -19.58683 -13.80931 25.05523  1.000 25.25442 ? 200 ILE A O   1 
ATOM   1525 C CB  . ILE A 1 200 ? -20.11259 -15.40535 22.77300  1.000 24.37678 ? 200 ILE A CB  1 
ATOM   1526 C CG1 . ILE A 1 200 ? -20.11955 -15.86361 21.30339  1.000 23.92487 ? 200 ILE A CG1 1 
ATOM   1527 C CG2 . ILE A 1 200 ? -21.00505 -16.31824 23.60982  1.000 22.72399 ? 200 ILE A CG2 1 
ATOM   1528 C CD1 . ILE A 1 200 ? -19.10780 -16.93610 20.98067  1.000 21.60213 ? 200 ILE A CD1 1 
ATOM   1529 N N   . THR A 1 201 ? -21.37369 -12.47758 24.62891  1.000 24.93765 ? 201 THR A N   1 
ATOM   1530 C CA  . THR A 1 201 ? -21.31456 -11.73788 25.89094  1.000 21.84890 ? 201 THR A CA  1 
ATOM   1531 C C   . THR A 1 201 ? -21.11323 -12.63260 27.10706  1.000 23.70960 ? 201 THR A C   1 
ATOM   1532 O O   . THR A 1 201 ? -20.29889 -12.32128 27.98416  1.000 25.68962 ? 201 THR A O   1 
ATOM   1533 C CB  . THR A 1 201 ? -22.59480 -10.92163 26.06140  1.000 24.33372 ? 201 THR A CB  1 
ATOM   1534 O OG1 . THR A 1 201 ? -22.86506 -10.22214 24.84597  1.000 25.17602 ? 201 THR A OG1 1 
ATOM   1535 C CG2 . THR A 1 201 ? -22.43066 -9.89613  27.19705  1.000 26.15541 ? 201 THR A CG2 1 
ATOM   1536 N N   . VAL A 1 202 ? -21.88671 -13.71169 27.21687  1.000 21.75364 ? 202 VAL A N   1 
ATOM   1537 C CA  . VAL A 1 202 ? -21.80481 -14.52186 28.43107  1.000 23.91084 ? 202 VAL A CA  1 
ATOM   1538 C C   . VAL A 1 202 ? -20.42487 -15.15212 28.55775  1.000 22.81944 ? 202 VAL A C   1 
ATOM   1539 O O   . VAL A 1 202 ? -19.93499 -15.37711 29.67025  1.000 22.77132 ? 202 VAL A O   1 
ATOM   1540 C CB  . VAL A 1 202 ? -22.91800 -15.59439 28.47065  1.000 25.19929 ? 202 VAL A CB  1 
ATOM   1541 C CG1 . VAL A 1 202 ? -22.79113 -16.59286 27.31643  1.000 31.25404 ? 202 VAL A CG1 1 
ATOM   1542 C CG2 . VAL A 1 202 ? -22.90047 -16.32685 29.79868  1.000 24.40942 ? 202 VAL A CG2 1 
ATOM   1543 N N   . ASN A 1 203 ? -19.76781 -15.41759 27.42680  1.000 23.01168 ? 203 ASN A N   1 
ATOM   1544 C CA  . ASN A 1 203 ? -18.42132 -15.98237 27.45244  1.000 23.17337 ? 203 ASN A CA  1 
ATOM   1545 C C   . ASN A 1 203 ? -17.39293 -14.94436 27.86362  1.000 24.07187 ? 203 ASN A C   1 
ATOM   1546 O O   . ASN A 1 203 ? -16.42887 -15.26565 28.57275  1.000 22.78651 ? 203 ASN A O   1 
ATOM   1547 C CB  . ASN A 1 203 ? -18.06001 -16.54671 26.07257  1.000 18.84621 ? 203 ASN A CB  1 
ATOM   1548 C CG  . ASN A 1 203 ? -18.85405 -17.78825 25.72655  1.000 26.35275 ? 203 ASN A CG  1 
ATOM   1549 O OD1 . ASN A 1 203 ? -19.75730 -18.18900 26.46830  1.000 21.22045 ? 203 ASN A OD1 1 
ATOM   1550 N ND2 . ASN A 1 203 ? -18.54838 -18.38912 24.57057  1.000 23.98590 ? 203 ASN A ND2 1 
ATOM   1551 N N   . VAL A 1 204 ? -17.55345 -13.70353 27.39503  1.000 22.61756 ? 204 VAL A N   1 
ATOM   1552 C CA  . VAL A 1 204 ? -16.65723 -12.63689 27.83365  1.000 20.62996 ? 204 VAL A CA  1 
ATOM   1553 C C   . VAL A 1 204 ? -16.71432 -12.49985 29.34887  1.000 25.17717 ? 204 VAL A C   1 
ATOM   1554 O O   . VAL A 1 204 ? -15.68314 -12.34735 30.01805  1.000 21.49103 ? 204 VAL A O   1 
ATOM   1555 C CB  . VAL A 1 204 ? -17.01226 -11.30967 27.14380  1.000 19.83493 ? 204 VAL A CB  1 
ATOM   1556 C CG1 . VAL A 1 204 ? -16.12108 -10.19965 27.68885  1.000 26.73388 ? 204 VAL A CG1 1 
ATOM   1557 C CG2 . VAL A 1 204 ? -16.82775 -11.41905 25.60267  1.000 22.06639 ? 204 VAL A CG2 1 
ATOM   1558 N N   . LEU A 1 205 ? -17.92176 -12.55212 29.91596  1.000 20.77658 ? 205 LEU A N   1 
ATOM   1559 C CA  . LEU A 1 205 ? -18.04328 -12.37967 31.36040  1.000 20.13559 ? 205 LEU A CA  1 
ATOM   1560 C C   . LEU A 1 205 ? -17.35923 -13.50984 32.10154  1.000 19.52408 ? 205 LEU A C   1 
ATOM   1561 O O   . LEU A 1 205 ? -16.65748 -13.27169 33.09549  1.000 24.42952 ? 205 LEU A O   1 
ATOM   1562 C CB  . LEU A 1 205 ? -19.51571 -12.29122 31.76269  1.000 21.88497 ? 205 LEU A CB  1 
ATOM   1563 C CG  . LEU A 1 205 ? -20.14599 -10.99297 31.25073  1.000 20.90018 ? 205 LEU A CG  1 
ATOM   1564 C CD1 . LEU A 1 205 ? -21.62585 -11.11363 31.39413  1.000 24.46284 ? 205 LEU A CD1 1 
ATOM   1565 C CD2 . LEU A 1 205 ? -19.62471 -9.80276  32.01696  1.000 28.16671 ? 205 LEU A CD2 1 
ATOM   1566 N N   . ALA A 1 206 ? -17.57293 -14.75291 31.65101  1.000 23.07850 ? 206 ALA A N   1 
ATOM   1567 C CA  . ALA A 1 206 ? -16.90272 -15.88757 32.27301  1.000 23.89409 ? 206 ALA A CA  1 
ATOM   1568 C C   . ALA A 1 206 ? -15.39588 -15.71282 32.24933  1.000 22.97776 ? 206 ALA A C   1 
ATOM   1569 O O   . ALA A 1 206 ? -14.71641 -15.99881 33.24422  1.000 20.54007 ? 206 ALA A O   1 
ATOM   1570 C CB  . ALA A 1 206 ? -17.30491 -17.18991 31.57997  1.000 25.40056 ? 206 ALA A CB  1 
ATOM   1571 N N   . TRP A 1 207 ? -14.85630 -15.23410 31.12455  1.000 19.47046 ? 207 TRP A N   1 
ATOM   1572 C CA  . TRP A 1 207 ? -13.41508 -15.03190 31.01219  1.000 24.07676 ? 207 TRP A CA  1 
ATOM   1573 C C   . TRP A 1 207 ? -12.93275 -13.92877 31.96415  1.000 29.68199 ? 207 TRP A C   1 
ATOM   1574 O O   . TRP A 1 207 ? -11.84752 -14.03285 32.56196  1.000 23.08748 ? 207 TRP A O   1 
ATOM   1575 C CB  . TRP A 1 207 ? -13.08866 -14.74679 29.54099  1.000 19.83620 ? 207 TRP A CB  1 
ATOM   1576 C CG  . TRP A 1 207 ? -11.69803 -14.26313 29.19417  1.000 25.36225 ? 207 TRP A CG  1 
ATOM   1577 C CD1 . TRP A 1 207 ? -10.57261 -15.02419 29.02135  1.000 27.51135 ? 207 TRP A CD1 1 
ATOM   1578 C CD2 . TRP A 1 207 ? -11.31922 -12.91781 28.90444  1.000 22.72680 ? 207 TRP A CD2 1 
ATOM   1579 N NE1 . TRP A 1 207 ? -9.51305  -14.22013 28.67357  1.000 24.52690 ? 207 TRP A NE1 1 
ATOM   1580 C CE2 . TRP A 1 207 ? -9.94753  -12.92459 28.59420  1.000 23.51884 ? 207 TRP A CE2 1 
ATOM   1581 C CE3 . TRP A 1 207 ? -12.01195 -11.70486 28.87099  1.000 27.46754 ? 207 TRP A CE3 1 
ATOM   1582 C CZ2 . TRP A 1 207 ? -9.25126  -11.76090 28.25908  1.000 30.48166 ? 207 TRP A CZ2 1 
ATOM   1583 C CZ3 . TRP A 1 207 ? -11.31095 -10.54147 28.54388  1.000 29.34564 ? 207 TRP A CZ3 1 
ATOM   1584 C CH2 . TRP A 1 207 ? -9.94846  -10.58424 28.24708  1.000 28.51293 ? 207 TRP A CH2 1 
ATOM   1585 N N   . LEU A 1 208 ? -13.74984 -12.88600 32.16064  1.000 25.65304 ? 208 LEU A N   1 
ATOM   1586 C CA  . LEU A 1 208 ? -13.43644 -11.87738 33.16900  1.000 23.06419 ? 208 LEU A CA  1 
ATOM   1587 C C   . LEU A 1 208 ? -13.42990 -12.47695 34.57508  1.000 17.88429 ? 208 LEU A C   1 
ATOM   1588 O O   . LEU A 1 208 ? -12.60969 -12.08957 35.41544  1.000 27.15969 ? 208 LEU A O   1 
ATOM   1589 C CB  . LEU A 1 208 ? -14.43016 -10.71543 33.07104  1.000 19.33147 ? 208 LEU A CB  1 
ATOM   1590 C CG  . LEU A 1 208 ? -14.27955 -9.95260  31.74674  1.000 21.61223 ? 208 LEU A CG  1 
ATOM   1591 C CD1 . LEU A 1 208 ? -15.40704 -8.95021  31.54174  1.000 25.64922 ? 208 LEU A CD1 1 
ATOM   1592 C CD2 . LEU A 1 208 ? -12.92251 -9.25162  31.68530  1.000 21.48072 ? 208 LEU A CD2 1 
ATOM   1593 N N   . TYR A 1 209 ? -14.35237 -13.39312 34.86126  1.000 20.48696 ? 209 TYR A N   1 
ATOM   1594 C CA  . TYR A 1 209 ? -14.29846 -14.13323 36.11915  1.000 24.18049 ? 209 TYR A CA  1 
ATOM   1595 C C   . TYR A 1 209 ? -13.00854 -14.94847 36.22069  1.000 24.73486 ? 209 TYR A C   1 
ATOM   1596 O O   . TYR A 1 209 ? -12.32646 -14.92439 37.24991  1.000 23.38120 ? 209 TYR A O   1 
ATOM   1597 C CB  . TYR A 1 209 ? -15.52919 -15.03744 36.25602  1.000 24.80211 ? 209 TYR A CB  1 
ATOM   1598 C CG  . TYR A 1 209 ? -16.76634 -14.31645 36.78115  1.000 27.31523 ? 209 TYR A CG  1 
ATOM   1599 C CD1 . TYR A 1 209 ? -16.83632 -13.90988 38.11013  1.000 26.14072 ? 209 TYR A CD1 1 
ATOM   1600 C CD2 . TYR A 1 209 ? -17.85234 -14.04401 35.95666  1.000 24.93694 ? 209 TYR A CD2 1 
ATOM   1601 C CE1 . TYR A 1 209 ? -17.94481 -13.24207 38.60818  1.000 30.62790 ? 209 TYR A CE1 1 
ATOM   1602 C CE2 . TYR A 1 209 ? -18.99132 -13.37404 36.45199  1.000 24.65376 ? 209 TYR A CE2 1 
ATOM   1603 C CZ  . TYR A 1 209 ? -19.01982 -12.97486 37.78430  1.000 27.59912 ? 209 TYR A CZ  1 
ATOM   1604 O OH  . TYR A 1 209 ? -20.11479 -12.30659 38.30584  1.000 27.63806 ? 209 TYR A OH  1 
ATOM   1605 N N   . ALA A 1 210 ? -12.66947 -15.69072 35.16106  1.000 23.93487 ? 210 ALA A N   1 
ATOM   1606 C CA  . ALA A 1 210 ? -11.37978 -16.38152 35.09518  1.000 24.53065 ? 210 ALA A CA  1 
ATOM   1607 C C   . ALA A 1 210 ? -10.21638 -15.43872 35.38997  1.000 22.82669 ? 210 ALA A C   1 
ATOM   1608 O O   . ALA A 1 210 ? -9.26435  -15.81207 36.08524  1.000 24.84968 ? 210 ALA A O   1 
ATOM   1609 C CB  . ALA A 1 210 ? -11.19185 -16.99791 33.70638  1.000 22.34211 ? 210 ALA A CB  1 
ATOM   1610 N N   . ALA A 1 211 ? -10.26084 -14.21782 34.84900  1.000 25.81630 ? 211 ALA A N   1 
ATOM   1611 C CA  . ALA A 1 211 ? -9.16140  -13.27584 35.06765  1.000 22.48294 ? 211 ALA A CA  1 
ATOM   1612 C C   . ALA A 1 211 ? -9.05329  -12.89694 36.53789  1.000 27.52993 ? 211 ALA A C   1 
ATOM   1613 O O   . ALA A 1 211 ? -7.94697  -12.83170 37.09288  1.000 28.68072 ? 211 ALA A O   1 
ATOM   1614 C CB  . ALA A 1 211 ? -9.35183  -12.02113 34.22105  1.000 23.39200 ? 211 ALA A CB  1 
ATOM   1615 N N   . VAL A 1 212 ? -10.19352 -12.65735 37.18519  1.000 26.55564 ? 212 VAL A N   1 
ATOM   1616 C CA  . VAL A 1 212 ? -10.18089 -12.30844 38.60261  1.000 27.29736 ? 212 VAL A CA  1 
ATOM   1617 C C   . VAL A 1 212 ? -9.58727  -13.44229 39.41460  1.000 29.68837 ? 212 VAL A C   1 
ATOM   1618 O O   . VAL A 1 212 ? -8.72572  -13.22141 40.27118  1.000 30.80126 ? 212 VAL A O   1 
ATOM   1619 C CB  . VAL A 1 212 ? -11.59809 -11.96022 39.08929  1.000 27.73888 ? 212 VAL A CB  1 
ATOM   1620 C CG1 . VAL A 1 212 ? -11.59355 -11.70759 40.60463  1.000 30.46989 ? 212 VAL A CG1 1 
ATOM   1621 C CG2 . VAL A 1 212 ? -12.11150 -10.75500 38.36072  1.000 22.08732 ? 212 VAL A CG2 1 
ATOM   1622 N N   . ILE A 1 213 ? -10.03987 -14.67521 39.15676  1.000 25.77605 ? 213 ILE A N   1 
ATOM   1623 C CA  . ILE A 1 213 ? -9.53516  -15.83526 39.88547  1.000 28.68385 ? 213 ILE A CA  1 
ATOM   1624 C C   . ILE A 1 213 ? -8.02454  -15.93942 39.75833  1.000 36.75159 ? 213 ILE A C   1 
ATOM   1625 O O   . ILE A 1 213 ? -7.34600  -16.41086 40.67954  1.000 34.26877 ? 213 ILE A O   1 
ATOM   1626 C CB  . ILE A 1 213 ? -10.23861 -17.10707 39.38085  1.000 28.47969 ? 213 ILE A CB  1 
ATOM   1627 C CG1 . ILE A 1 213 ? -11.73745 -17.03471 39.69115  1.000 24.87195 ? 213 ILE A CG1 1 
ATOM   1628 C CG2 . ILE A 1 213 ? -9.61005  -18.35390 39.97053  1.000 35.41880 ? 213 ILE A CG2 1 
ATOM   1629 C CD1 . ILE A 1 213 ? -12.54502 -18.15868 39.10277  1.000 31.22398 ? 213 ILE A CD1 1 
ATOM   1630 N N   . ASN A 1 214 ? -7.46486  -15.47322 38.64313  1.000 33.78051 ? 214 ASN A N   1 
ATOM   1631 C CA  . ASN A 1 214 ? -6.03980  -15.62136 38.39940  1.000 37.65547 ? 214 ASN A CA  1 
ATOM   1632 C C   . ASN A 1 214 ? -5.24296  -14.36287 38.69572  1.000 32.30834 ? 214 ASN A C   1 
ATOM   1633 O O   . ASN A 1 214 ? -4.05419  -14.31513 38.37290  1.000 38.16053 ? 214 ASN A O   1 
ATOM   1634 C CB  . ASN A 1 214 ? -5.80335  -16.09402 36.96467  1.000 36.00944 ? 214 ASN A CB  1 
ATOM   1635 C CG  . ASN A 1 214 ? -6.07811  -17.56653 36.81172  1.000 39.14487 ? 214 ASN A CG  1 
ATOM   1636 O OD1 . ASN A 1 214 ? -5.24391  -18.39532 37.17862  1.000 47.91087 ? 214 ASN A OD1 1 
ATOM   1637 N ND2 . ASN A 1 214 ? -7.27341  -17.91216 36.32265  1.000 32.53089 ? 214 ASN A ND2 1 
ATOM   1638 N N   . GLY A 1 215 ? -5.85783  -13.34759 39.31286  1.000 35.70835 ? 215 GLY A N   1 
ATOM   1639 C CA  . GLY A 1 215 ? -5.13672  -12.18411 39.78882  1.000 36.97022 ? 215 GLY A CA  1 
ATOM   1640 C C   . GLY A 1 215 ? -5.17127  -10.95638 38.89855  1.000 39.40641 ? 215 GLY A C   1 
ATOM   1641 O O   . GLY A 1 215 ? -4.64165  -9.91306  39.29744  1.000 36.59977 ? 215 GLY A O   1 
ATOM   1642 N N   . ASP A 1 216 ? -5.75527  -11.04311 37.70757  1.000 35.70315 ? 216 ASP A N   1 
ATOM   1643 C CA  . ASP A 1 216 ? -5.92896  -9.87467  36.85063  1.000 37.02822 ? 216 ASP A CA  1 
ATOM   1644 C C   . ASP A 1 216 ? -7.19346  -9.15537  37.29650  1.000 40.36202 ? 216 ASP A C   1 
ATOM   1645 O O   . ASP A 1 216 ? -8.30707  -9.62337  37.03212  1.000 40.66990 ? 216 ASP A O   1 
ATOM   1646 C CB  . ASP A 1 216 ? -6.01779  -10.29288 35.38633  1.000 35.88838 ? 216 ASP A CB  1 
ATOM   1647 C CG  . ASP A 1 216 ? -4.65703  -10.35708 34.70377  1.000 46.10087 ? 216 ASP A CG  1 
ATOM   1648 O OD1 . ASP A 1 216 ? -3.86567  -9.40556  34.86160  1.000 56.04099 ? 216 ASP A OD1 1 
ATOM   1649 O OD2 . ASP A 1 216 ? -4.38889  -11.35348 33.99223  1.000 42.60840 ? 216 ASP A OD2 1 
ATOM   1650 N N   . ARG A 1 217 ? -7.03078  -8.02530  37.98567  1.000 38.52759 ? 217 ARG A N   1 
ATOM   1651 C CA  . ARG A 1 217 ? -8.14867  -7.38057  38.65326  1.000 36.72419 ? 217 ARG A CA  1 
ATOM   1652 C C   . ARG A 1 217 ? -8.32289  -5.92101  38.28139  1.000 29.57083 ? 217 ARG A C   1 
ATOM   1653 O O   . ARG A 1 217 ? -9.30923  -5.31688  38.70948  1.000 32.40984 ? 217 ARG A O   1 
ATOM   1654 C CB  . ARG A 1 217 ? -7.99574  -7.46964  40.18006  1.000 34.02954 ? 217 ARG A CB  1 
ATOM   1655 C CG  . ARG A 1 217 ? -8.08108  -8.86882  40.78312  1.000 47.59425 ? 217 ARG A CG  1 
ATOM   1656 C CD  . ARG A 1 217 ? -7.87827  -8.79910  42.30835  1.000 53.36097 ? 217 ARG A CD  1 
ATOM   1657 N NE  . ARG A 1 217 ? -6.48151  -8.52919  42.63424  1.000 49.86028 ? 217 ARG A NE  1 
ATOM   1658 C CZ  . ARG A 1 217 ? -5.97853  -7.33661  42.93132  1.000 56.26597 ? 217 ARG A CZ  1 
ATOM   1659 N NH1 . ARG A 1 217 ? -6.74902  -6.26226  43.03754  1.000 51.79430 ? 217 ARG A NH1 1 
ATOM   1660 N NH2 . ARG A 1 217 ? -4.66550  -7.21682  43.11711  1.000 54.28999 ? 217 ARG A NH2 1 
ATOM   1661 N N   . TRP A 1 218 ? -7.40136  -5.33876  37.50211  1.000 33.64119 ? 218 TRP A N   1 
ATOM   1662 C CA  . TRP A 1 218 ? -7.39685  -3.90214  37.26103  1.000 35.12193 ? 218 TRP A CA  1 
ATOM   1663 C C   . TRP A 1 218 ? -8.68895  -3.39547  36.63882  1.000 34.34494 ? 218 TRP A C   1 
ATOM   1664 O O   . TRP A 1 218 ? -8.99315  -2.20795  36.76390  1.000 36.68349 ? 218 TRP A O   1 
ATOM   1665 C CB  . TRP A 1 218 ? -6.21909  -3.51653  36.36425  1.000 41.84543 ? 218 TRP A CB  1 
ATOM   1666 C CG  . TRP A 1 218 ? -6.23480  -4.12296  34.97791  1.000 39.90223 ? 218 TRP A CG  1 
ATOM   1667 C CD1 . TRP A 1 218 ? -5.54136  -5.21980  34.56092  1.000 40.19638 ? 218 TRP A CD1 1 
ATOM   1668 C CD2 . TRP A 1 218 ? -6.95996  -3.64907  33.83081  1.000 38.67183 ? 218 TRP A CD2 1 
ATOM   1669 N NE1 . TRP A 1 218 ? -5.78511  -5.45739  33.22772  1.000 43.30004 ? 218 TRP A NE1 1 
ATOM   1670 C CE2 . TRP A 1 218 ? -6.65787  -4.51231  32.75865  1.000 36.85559 ? 218 TRP A CE2 1 
ATOM   1671 C CE3 . TRP A 1 218 ? -7.83537  -2.58780  33.61003  1.000 29.83318 ? 218 TRP A CE3 1 
ATOM   1672 C CZ2 . TRP A 1 218 ? -7.19617  -4.33906  31.48490  1.000 31.47113 ? 218 TRP A CZ2 1 
ATOM   1673 C CZ3 . TRP A 1 218 ? -8.36788  -2.41408  32.34973  1.000 42.47275 ? 218 TRP A CZ3 1 
ATOM   1674 C CH2 . TRP A 1 218 ? -8.04707  -3.28931  31.29874  1.000 37.10508 ? 218 TRP A CH2 1 
ATOM   1675 N N   . PHE A 1 219 ? -9.44383  -4.25240  35.96018  1.000 36.42385 ? 219 PHE A N   1 
ATOM   1676 C CA  . PHE A 1 219 ? -10.66095 -3.81802  35.28696  1.000 33.78864 ? 219 PHE A CA  1 
ATOM   1677 C C   . PHE A 1 219 ? -11.86987 -3.78650  36.21166  1.000 31.92012 ? 219 PHE A C   1 
ATOM   1678 O O   . PHE A 1 219 ? -12.94203 -3.34643  35.79104  1.000 33.29153 ? 219 PHE A O   1 
ATOM   1679 C CB  . PHE A 1 219 ? -10.94559 -4.73938  34.09424  1.000 30.90510 ? 219 PHE A CB  1 
ATOM   1680 C CG  . PHE A 1 219 ? -10.99572 -6.18008  34.46912  1.000 30.25557 ? 219 PHE A CG  1 
ATOM   1681 C CD1 . PHE A 1 219 ? -12.16990 -6.74687  34.94930  1.000 31.04540 ? 219 PHE A CD1 1 
ATOM   1682 C CD2 . PHE A 1 219 ? -9.85658  -6.96728  34.37922  1.000 28.40260 ? 219 PHE A CD2 1 
ATOM   1683 C CE1 . PHE A 1 219 ? -12.21060 -8.07821  35.32876  1.000 27.14747 ? 219 PHE A CE1 1 
ATOM   1684 C CE2 . PHE A 1 219 ? -9.89329  -8.29412  34.75420  1.000 32.71069 ? 219 PHE A CE2 1 
ATOM   1685 C CZ  . PHE A 1 219 ? -11.08001 -8.85062  35.23000  1.000 28.88249 ? 219 PHE A CZ  1 
ATOM   1686 N N   . LEU A 1 220 ? -11.74496 -4.25208  37.44680  1.000 34.84468 ? 220 LEU A N   1 
ATOM   1687 C CA  . LEU A 1 220 ? -12.87149 -4.15655  38.36259  1.000 36.09890 ? 220 LEU A CA  1 
ATOM   1688 C C   . LEU A 1 220 ? -13.08360 -2.69818  38.77081  1.000 40.81126 ? 220 LEU A C   1 
ATOM   1689 O O   . LEU A 1 220 ? -12.12971 -1.98650  39.11105  1.000 40.51429 ? 220 LEU A O   1 
ATOM   1690 C CB  . LEU A 1 220 ? -12.63657 -5.04241  39.58245  1.000 38.66466 ? 220 LEU A CB  1 
ATOM   1691 C CG  . LEU A 1 220 ? -12.49088 -6.55210  39.34552  1.000 32.49364 ? 220 LEU A CG  1 
ATOM   1692 C CD1 . LEU A 1 220 ? -12.16686 -7.25602  40.65798  1.000 37.18308 ? 220 LEU A CD1 1 
ATOM   1693 C CD2 . LEU A 1 220 ? -13.73728 -7.15679  38.68788  1.000 30.31674 ? 220 LEU A CD2 1 
ATOM   1694 N N   . ASN A 1 221 ? -14.32873 -2.24083  38.71794  1.000 39.43749 ? 221 ASN A N   1 
ATOM   1695 C CA  . ASN A 1 221 ? -14.62515 -0.84651  39.02017  1.000 42.75972 ? 221 ASN A CA  1 
ATOM   1696 C C   . ASN A 1 221 ? -15.65530 -0.75692  40.14494  1.000 40.55463 ? 221 ASN A C   1 
ATOM   1697 O O   . ASN A 1 221 ? -16.08892 -1.76759  40.70351  1.000 35.18223 ? 221 ASN A O   1 
ATOM   1698 C CB  . ASN A 1 221 ? -15.09584 -0.11068  37.76637  1.000 38.63323 ? 221 ASN A CB  1 
ATOM   1699 C CG  . ASN A 1 221 ? -16.33596 -0.73388  37.15263  1.000 48.42017 ? 221 ASN A CG  1 
ATOM   1700 O OD1 . ASN A 1 221 ? -17.24529 -1.19562  37.85078  1.000 34.40334 ? 221 ASN A OD1 1 
ATOM   1701 N ND2 . ASN A 1 221 ? -16.37810 -0.74666  35.82562  1.000 49.72263 ? 221 ASN A ND2 1 
ATOM   1702 N N   . ARG A 1 222 ? -16.04911 0.48056   40.45917  1.000 46.77312 ? 222 ARG A N   1 
ATOM   1703 C CA  . ARG A 1 222 ? -16.94416 0.79628   41.56608  1.000 46.00372 ? 222 ARG A CA  1 
ATOM   1704 C C   . ARG A 1 222 ? -18.41340 0.85973   41.16379  1.000 43.06636 ? 222 ARG A C   1 
ATOM   1705 O O   . ARG A 1 222 ? -19.26360 1.12208   42.02151  1.000 43.01031 ? 222 ARG A O   1 
ATOM   1706 C CB  . ARG A 1 222 ? -16.53846 2.13632   42.20123  1.000 52.89041 ? 222 ARG A CB  1 
ATOM   1707 N N   . PHE A 1 223 ? -18.73568 0.63280   39.89658  1.000 39.86607 ? 223 PHE A N   1 
ATOM   1708 C CA  . PHE A 1 223 ? -20.08813 0.82679   39.39920  1.000 34.43040 ? 223 PHE A CA  1 
ATOM   1709 C C   . PHE A 1 223 ? -20.82661 -0.49374  39.30800  1.000 33.49080 ? 223 PHE A C   1 
ATOM   1710 O O   . PHE A 1 223 ? -20.24093 -1.57898  39.36726  1.000 34.47209 ? 223 PHE A O   1 
ATOM   1711 C CB  . PHE A 1 223 ? -20.08005 1.48175   38.01959  1.000 37.29653 ? 223 PHE A CB  1 
ATOM   1712 C CG  . PHE A 1 223 ? -18.91380 2.38437   37.79305  1.000 44.72907 ? 223 PHE A CG  1 
ATOM   1713 C CD1 . PHE A 1 223 ? -18.78944 3.56264   38.49328  1.000 47.40790 ? 223 PHE A CD1 1 
ATOM   1714 C CD2 . PHE A 1 223 ? -17.94217 2.05527   36.87742  1.000 49.32758 ? 223 PHE A CD2 1 
ATOM   1715 C CE1 . PHE A 1 223 ? -17.70824 4.39243   38.28148  1.000 53.98134 ? 223 PHE A CE1 1 
ATOM   1716 C CE2 . PHE A 1 223 ? -16.86069 2.88638   36.66141  1.000 50.59275 ? 223 PHE A CE2 1 
ATOM   1717 C CZ  . PHE A 1 223 ? -16.74608 4.05687   37.36929  1.000 47.79259 ? 223 PHE A CZ  1 
ATOM   1718 N N   . THR A 1 224 ? -22.13267 -0.38373  39.14642  1.000 26.69271 ? 224 THR A N   1 
ATOM   1719 C CA  . THR A 1 224 ? -22.95043 -1.50570  38.75354  1.000 27.17962 ? 224 THR A CA  1 
ATOM   1720 C C   . THR A 1 224 ? -23.83738 -1.04314  37.60332  1.000 28.15433 ? 224 THR A C   1 
ATOM   1721 O O   . THR A 1 224 ? -23.70312 0.07594   37.09636  1.000 29.98378 ? 224 THR A O   1 
ATOM   1722 C CB  . THR A 1 224 ? -23.74840 -2.05914  39.94059  1.000 35.26797 ? 224 THR A CB  1 
ATOM   1723 O OG1 . THR A 1 224 ? -24.21565 -3.37704  39.62242  1.000 30.16146 ? 224 THR A OG1 1 
ATOM   1724 C CG2 . THR A 1 224 ? -24.93573 -1.16858  40.28177  1.000 36.95363 ? 224 THR A CG2 1 
ATOM   1725 N N   . THR A 1 225 ? -24.71578 -1.92598  37.15296  1.000 25.96857 ? 225 THR A N   1 
ATOM   1726 C CA  . THR A 1 225 ? -25.61870 -1.61551  36.06018  1.000 26.43841 ? 225 THR A CA  1 
ATOM   1727 C C   . THR A 1 225 ? -26.82186 -2.53884  36.20330  1.000 26.03106 ? 225 THR A C   1 
ATOM   1728 O O   . THR A 1 225 ? -26.95987 -3.25622  37.20038  1.000 26.23807 ? 225 THR A O   1 
ATOM   1729 C CB  . THR A 1 225 ? -24.90144 -1.76002  34.70475  1.000 29.88223 ? 225 THR A CB  1 
ATOM   1730 O OG1 . THR A 1 225 ? -25.74213 -1.28195  33.64551  1.000 29.58148 ? 225 THR A OG1 1 
ATOM   1731 C CG2 . THR A 1 225 ? -24.54997 -3.21670  34.42630  1.000 31.51924 ? 225 THR A CG2 1 
ATOM   1732 N N   . THR A 1 226 ? -27.71048 -2.50318  35.21931  1.000 29.05489 ? 226 THR A N   1 
ATOM   1733 C CA  . THR A 1 226 ? -28.85464 -3.39539  35.16967  1.000 29.87500 ? 226 THR A CA  1 
ATOM   1734 C C   . THR A 1 226 ? -28.80962 -4.15577  33.85750  1.000 26.62321 ? 226 THR A C   1 
ATOM   1735 O O   . THR A 1 226 ? -28.14787 -3.73373  32.90892  1.000 29.47172 ? 226 THR A O   1 
ATOM   1736 C CB  . THR A 1 226 ? -30.17571 -2.63135  35.24892  1.000 31.05716 ? 226 THR A CB  1 
ATOM   1737 O OG1 . THR A 1 226 ? -30.36553 -1.91350  34.01990  1.000 25.59308 ? 226 THR A OG1 1 
ATOM   1738 C CG2 . THR A 1 226 ? -30.14874 -1.64962  36.40178  1.000 36.88308 ? 226 THR A CG2 1 
ATOM   1739 N N   . LEU A 1 227 ? -29.56309 -5.25506  33.79799  1.000 26.70666 ? 227 LEU A N   1 
ATOM   1740 C CA  . LEU A 1 227 ? -29.61204 -6.04340  32.57012  1.000 34.80319 ? 227 LEU A CA  1 
ATOM   1741 C C   . LEU A 1 227 ? -29.97695 -5.16729  31.37137  1.000 37.72623 ? 227 LEU A C   1 
ATOM   1742 O O   . LEU A 1 227 ? -29.27977 -5.17898  30.34570  1.000 34.59377 ? 227 LEU A O   1 
ATOM   1743 C CB  . LEU A 1 227 ? -30.59819 -7.20695  32.74376  1.000 34.43695 ? 227 LEU A CB  1 
ATOM   1744 C CG  . LEU A 1 227 ? -30.24743 -8.51840  32.02779  1.000 44.57749 ? 227 LEU A CG  1 
ATOM   1745 C CD1 . LEU A 1 227 ? -28.82185 -8.92762  32.34272  1.000 38.49232 ? 227 LEU A CD1 1 
ATOM   1746 C CD2 . LEU A 1 227 ? -31.20434 -9.65802  32.36643  1.000 38.56468 ? 227 LEU A CD2 1 
ATOM   1747 N N   . ASN A 1 228 ? -31.03050 -4.34528  31.50641  1.000 37.00092 ? 228 ASN A N   1 
ATOM   1748 C CA  . ASN A 1 228 ? -31.46173 -3.49435  30.39456  1.000 33.34830 ? 228 ASN A CA  1 
ATOM   1749 C C   . ASN A 1 228 ? -30.42161 -2.42525  30.06467  1.000 29.50152 ? 228 ASN A C   1 
ATOM   1750 O O   . ASN A 1 228 ? -30.14944 -2.15142  28.88774  1.000 37.63601 ? 228 ASN A O   1 
ATOM   1751 C CB  . ASN A 1 228 ? -32.81943 -2.85103  30.71660  1.000 36.98648 ? 228 ASN A CB  1 
ATOM   1752 C CG  . ASN A 1 228 ? -33.99577 -3.81049  30.50490  1.000 35.72572 ? 228 ASN A CG  1 
ATOM   1753 O OD1 . ASN A 1 228 ? -33.86970 -4.83928  29.83866  1.000 38.05728 ? 228 ASN A OD1 1 
ATOM   1754 N ND2 . ASN A 1 228 ? -35.14530 -3.46048  31.05477  1.000 30.94371 ? 228 ASN A ND2 1 
ATOM   1755 N N   . ASP A 1 229 ? -29.82942 -1.81209  31.08349  1.000 30.41414 ? 229 ASP A N   1 
ATOM   1756 C CA  . ASP A 1 229 ? -28.83957 -0.77323  30.83692  1.000 37.06297 ? 229 ASP A CA  1 
ATOM   1757 C C   . ASP A 1 229 ? -27.59756 -1.34794  30.16115  1.000 31.49818 ? 229 ASP A C   1 
ATOM   1758 O O   . ASP A 1 229 ? -27.05550 -0.74203  29.23312  1.000 29.25314 ? 229 ASP A O   1 
ATOM   1759 C CB  . ASP A 1 229 ? -28.47538 -0.07594  32.14991  1.000 31.78813 ? 229 ASP A CB  1 
ATOM   1760 C CG  . ASP A 1 229 ? -27.32840 0.91312   31.98863  1.000 46.17871 ? 229 ASP A CG  1 
ATOM   1761 O OD1 . ASP A 1 229 ? -27.50549 1.91482   31.26350  1.000 48.58270 ? 229 ASP A OD1 1 
ATOM   1762 O OD2 . ASP A 1 229 ? -26.24921 0.68889   32.59192  1.000 48.89193 ? 229 ASP A OD2 1 
ATOM   1763 N N   . PHE A 1 230 ? -27.13263 -2.51520  30.61107  1.000 33.65661 ? 230 PHE A N   1 
ATOM   1764 C CA  . PHE A 1 230 ? -25.98441 -3.12796  29.95796  1.000 30.67947 ? 230 PHE A CA  1 
ATOM   1765 C C   . PHE A 1 230 ? -26.29074 -3.44740  28.50102  1.000 26.87363 ? 230 PHE A C   1 
ATOM   1766 O O   . PHE A 1 230 ? -25.49619 -3.13557  27.60587  1.000 34.35732 ? 230 PHE A O   1 
ATOM   1767 C CB  . PHE A 1 230 ? -25.56237 -4.39004  30.70133  1.000 31.09992 ? 230 PHE A CB  1 
ATOM   1768 C CG  . PHE A 1 230 ? -24.51543 -5.16862  29.97844  1.000 33.75430 ? 230 PHE A CG  1 
ATOM   1769 C CD1 . PHE A 1 230 ? -23.19564 -4.74036  29.98432  1.000 33.52014 ? 230 PHE A CD1 1 
ATOM   1770 C CD2 . PHE A 1 230 ? -24.85218 -6.30506  29.26201  1.000 31.46996 ? 230 PHE A CD2 1 
ATOM   1771 C CE1 . PHE A 1 230 ? -22.22608 -5.44123  29.29450  1.000 34.03293 ? 230 PHE A CE1 1 
ATOM   1772 C CE2 . PHE A 1 230 ? -23.88892 -7.01224  28.57519  1.000 33.07823 ? 230 PHE A CE2 1 
ATOM   1773 C CZ  . PHE A 1 230 ? -22.57431 -6.57724  28.58444  1.000 28.38048 ? 230 PHE A CZ  1 
ATOM   1774 N N   . ASN A 1 231 ? -27.44366 -4.05674  28.24911  1.000 27.99347 ? 231 ASN A N   1 
ATOM   1775 C CA  . ASN A 1 231 ? -27.79448 -4.49268  26.89886  1.000 33.32261 ? 231 ASN A CA  1 
ATOM   1776 C C   . ASN A 1 231 ? -27.87410 -3.33413  25.91515  1.000 37.53489 ? 231 ASN A C   1 
ATOM   1777 O O   . ASN A 1 231 ? -27.59823 -3.51997  24.72359  1.000 37.18839 ? 231 ASN A O   1 
ATOM   1778 C CB  . ASN A 1 231 ? -29.11321 -5.26538  26.93138  1.000 33.39553 ? 231 ASN A CB  1 
ATOM   1779 C CG  . ASN A 1 231 ? -28.91167 -6.71808  27.31151  1.000 32.27304 ? 231 ASN A CG  1 
ATOM   1780 O OD1 . ASN A 1 231 ? -27.81559 -7.24243  27.14338  1.000 30.98652 ? 231 ASN A OD1 1 
ATOM   1781 N ND2 . ASN A 1 231 ? -29.96004 -7.37757  27.81406  1.000 31.10795 ? 231 ASN A ND2 1 
ATOM   1782 N N   . LEU A 1 232 ? -28.24728 -2.13665  26.38053  1.000 39.10545 ? 232 LEU A N   1 
ATOM   1783 C CA  . LEU A 1 232 ? -28.16464 -0.96547  25.51314  1.000 31.94108 ? 232 LEU A CA  1 
ATOM   1784 C C   . LEU A 1 232 ? -26.73806 -0.75589  25.02978  1.000 38.55054 ? 232 LEU A C   1 
ATOM   1785 O O   . LEU A 1 232 ? -26.50532 -0.45160  23.85152  1.000 40.87150 ? 232 LEU A O   1 
ATOM   1786 C CB  . LEU A 1 232 ? -28.65730 0.28096   26.24866  1.000 35.22449 ? 232 LEU A CB  1 
ATOM   1787 C CG  . LEU A 1 232 ? -30.14525 0.38372   26.55019  1.000 38.11183 ? 232 LEU A CG  1 
ATOM   1788 C CD1 . LEU A 1 232 ? -30.44315 1.74135   27.18196  1.000 36.08699 ? 232 LEU A CD1 1 
ATOM   1789 C CD2 . LEU A 1 232 ? -30.95476 0.18176   25.27552  1.000 34.03326 ? 232 LEU A CD2 1 
ATOM   1790 N N   . VAL A 1 233 ? -25.76743 -0.92482  25.92614  1.000 33.32353 ? 233 VAL A N   1 
ATOM   1791 C CA  . VAL A 1 233 ? -24.36651 -0.84768  25.52352  1.000 40.36788 ? 233 VAL A CA  1 
ATOM   1792 C C   . VAL A 1 233 ? -23.97147 -2.05982  24.68257  1.000 37.56589 ? 233 VAL A C   1 
ATOM   1793 O O   . VAL A 1 233 ? -23.21183 -1.93653  23.71249  1.000 38.38661 ? 233 VAL A O   1 
ATOM   1794 C CB  . VAL A 1 233 ? -23.47206 -0.70173  26.76391  1.000 38.27122 ? 233 VAL A CB  1 
ATOM   1795 C CG1 . VAL A 1 233 ? -21.99918 -0.69552  26.35146  1.000 38.72411 ? 233 VAL A CG1 1 
ATOM   1796 C CG2 . VAL A 1 233 ? -23.83048 0.57398   27.51276  1.000 29.45406 ? 233 VAL A CG2 1 
ATOM   1797 N N   . ALA A 1 234 ? -24.47064 -3.24595  25.03666  1.000 38.79567 ? 234 ALA A N   1 
ATOM   1798 C CA  . ALA A 1 234 ? -24.14853 -4.44054  24.25920  1.000 36.77327 ? 234 ALA A CA  1 
ATOM   1799 C C   . ALA A 1 234 ? -24.55153 -4.27546  22.79953  1.000 40.31908 ? 234 ALA A C   1 
ATOM   1800 O O   . ALA A 1 234 ? -23.75394 -4.54495  21.89241  1.000 35.55523 ? 234 ALA A O   1 
ATOM   1801 C CB  . ALA A 1 234 ? -24.82975 -5.66556  24.86702  1.000 35.11440 ? 234 ALA A CB  1 
ATOM   1802 N N   . MET A 1 235 ? -25.78327 -3.81974  22.55698  1.000 32.36068 ? 235 MET A N   1 
ATOM   1803 C CA  . MET A 1 235 ? -26.25438 -3.59142  21.19423  1.000 33.50201 ? 235 MET A CA  1 
ATOM   1804 C C   . MET A 1 235 ? -25.31694 -2.67020  20.42175  1.000 36.92900 ? 235 MET A C   1 
ATOM   1805 O O   . MET A 1 235 ? -24.98824 -2.93460  19.25871  1.000 35.73548 ? 235 MET A O   1 
ATOM   1806 C CB  . MET A 1 235 ? -27.66762 -3.00277  21.23187  1.000 42.20413 ? 235 MET A CB  1 
ATOM   1807 N N   . LYS A 1 236 ? -24.88069 -1.57761  21.04508  1.000 34.41591 ? 236 LYS A N   1 
ATOM   1808 C CA  . LYS A 1 236 ? -24.02646 -0.63333  20.33629  1.000 33.66052 ? 236 LYS A CA  1 
ATOM   1809 C C   . LYS A 1 236 ? -22.72653 -1.28277  19.87031  1.000 33.64316 ? 236 LYS A C   1 
ATOM   1810 O O   . LYS A 1 236 ? -22.22327 -0.95178  18.79201  1.000 31.11712 ? 236 LYS A O   1 
ATOM   1811 C CB  . LYS A 1 236 ? -23.75731 0.58284   21.22613  1.000 40.72920 ? 236 LYS A CB  1 
ATOM   1812 C CG  . LYS A 1 236 ? -22.77195 1.58039   20.62718  1.000 45.76302 ? 236 LYS A CG  1 
ATOM   1813 C CD  . LYS A 1 236 ? -22.77762 2.92362   21.35112  1.000 43.69007 ? 236 LYS A CD  1 
ATOM   1814 C CE  . LYS A 1 236 ? -21.47930 3.68614   21.07680  1.000 49.60665 ? 236 LYS A CE  1 
ATOM   1815 N NZ  . LYS A 1 236 ? -21.58323 5.15804   21.30913  1.000 56.53146 ? 236 LYS A NZ  1 
ATOM   1816 N N   . TYR A 1 237 ? -22.19687 -2.24577  20.63026  1.000 31.77936 ? 237 TYR A N   1 
ATOM   1817 C CA  . TYR A 1 237 ? -20.90508 -2.85609  20.33132  1.000 30.52563 ? 237 TYR A CA  1 
ATOM   1818 C C   . TYR A 1 237 ? -21.02470 -4.22882  19.67526  1.000 32.56250 ? 237 TYR A C   1 
ATOM   1819 O O   . TYR A 1 237 ? -20.04350 -4.98362  19.65544  1.000 31.25988 ? 237 TYR A O   1 
ATOM   1820 C CB  . TYR A 1 237 ? -20.06013 -2.93172  21.60572  1.000 27.06564 ? 237 TYR A CB  1 
ATOM   1821 C CG  . TYR A 1 237 ? -19.54864 -1.56379  21.99269  1.000 33.52351 ? 237 TYR A CG  1 
ATOM   1822 C CD1 . TYR A 1 237 ? -18.39298 -1.05063  21.41030  1.000 32.08080 ? 237 TYR A CD1 1 
ATOM   1823 C CD2 . TYR A 1 237 ? -20.24017 -0.76717  22.89400  1.000 32.60935 ? 237 TYR A CD2 1 
ATOM   1824 C CE1 . TYR A 1 237 ? -17.92889 0.20647   21.72540  1.000 34.84912 ? 237 TYR A CE1 1 
ATOM   1825 C CE2 . TYR A 1 237 ? -19.78240 0.49951   23.21641  1.000 29.72207 ? 237 TYR A CE2 1 
ATOM   1826 C CZ  . TYR A 1 237 ? -18.62132 0.97945   22.62893  1.000 37.29728 ? 237 TYR A CZ  1 
ATOM   1827 O OH  . TYR A 1 237 ? -18.13693 2.23762   22.94065  1.000 35.74743 ? 237 TYR A OH  1 
ATOM   1828 N N   . ASN A 1 238 ? -22.18953 -4.54147  19.10277  1.000 27.53289 ? 238 ASN A N   1 
ATOM   1829 C CA  . ASN A 1 238 ? -22.46221 -5.83411  18.45756  1.000 31.37447 ? 238 ASN A CA  1 
ATOM   1830 C C   . ASN A 1 238 ? -22.14320 -7.00935  19.37982  1.000 32.77872 ? 238 ASN A C   1 
ATOM   1831 O O   . ASN A 1 238 ? -21.54481 -8.00744  18.97332  1.000 33.02389 ? 238 ASN A O   1 
ATOM   1832 C CB  . ASN A 1 238 ? -21.72273 -5.95677  17.12519  1.000 34.19746 ? 238 ASN A CB  1 
ATOM   1833 C CG  . ASN A 1 238 ? -22.27604 -5.01171  16.07516  1.000 38.66650 ? 238 ASN A CG  1 
ATOM   1834 O OD1 . ASN A 1 238 ? -23.47429 -4.75754  16.03398  1.000 36.39715 ? 238 ASN A OD1 1 
ATOM   1835 N ND2 . ASN A 1 238 ? -21.40411 -4.47643  15.23741  1.000 41.18163 ? 238 ASN A ND2 1 
ATOM   1836 N N   . TYR A 1 239 ? -22.53938 -6.87519  20.63344  1.000 27.58285 ? 239 TYR A N   1 
ATOM   1837 C CA  . TYR A 1 239 ? -22.49946 -7.93722  21.62020  1.000 27.05753 ? 239 TYR A CA  1 
ATOM   1838 C C   . TYR A 1 239 ? -23.86234 -8.59939  21.69105  1.000 26.73453 ? 239 TYR A C   1 
ATOM   1839 O O   . TYR A 1 239 ? -24.88688 -7.93476  21.52725  1.000 27.94555 ? 239 TYR A O   1 
ATOM   1840 C CB  . TYR A 1 239 ? -22.14447 -7.37566  22.99263  1.000 29.01932 ? 239 TYR A CB  1 
ATOM   1841 C CG  . TYR A 1 239 ? -20.68632 -7.41062  23.30396  1.000 30.39494 ? 239 TYR A CG  1 
ATOM   1842 C CD1 . TYR A 1 239 ? -19.77129 -6.79283  22.47934  1.000 25.93783 ? 239 TYR A CD1 1 
ATOM   1843 C CD2 . TYR A 1 239 ? -20.22605 -8.06414  24.43255  1.000 24.82407 ? 239 TYR A CD2 1 
ATOM   1844 C CE1 . TYR A 1 239 ? -18.40898 -6.83166  22.76585  1.000 32.02906 ? 239 TYR A CE1 1 
ATOM   1845 C CE2 . TYR A 1 239 ? -18.88197 -8.10899  24.72813  1.000 26.86051 ? 239 TYR A CE2 1 
ATOM   1846 C CZ  . TYR A 1 239 ? -17.97677 -7.49515  23.89611  1.000 31.58309 ? 239 TYR A CZ  1 
ATOM   1847 O OH  . TYR A 1 239 ? -16.63001 -7.53756  24.19941  1.000 29.47911 ? 239 TYR A OH  1 
ATOM   1848 N N   . GLU A 1 240 ? -23.87503 -9.90972  21.96396  1.000 24.66176 ? 240 GLU A N   1 
ATOM   1849 C CA  . GLU A 1 240 ? -25.14402 -10.61446 22.11472  1.000 28.83572 ? 240 GLU A CA  1 
ATOM   1850 C C   . GLU A 1 240 ? -25.87599 -10.09672 23.34846  1.000 34.94853 ? 240 GLU A C   1 
ATOM   1851 O O   . GLU A 1 240 ? -25.24178 -9.78759  24.36066  1.000 33.67247 ? 240 GLU A O   1 
ATOM   1852 C CB  . GLU A 1 240 ? -24.93873 -12.12778 22.24423  1.000 31.01866 ? 240 GLU A CB  1 
ATOM   1853 C CG  . GLU A 1 240 ? -24.58540 -12.83138 20.93711  1.000 41.24972 ? 240 GLU A CG  1 
ATOM   1854 C CD  . GLU A 1 240 ? -25.77906 -12.97551 19.99083  1.000 52.03371 ? 240 GLU A CD  1 
ATOM   1855 O OE1 . GLU A 1 240 ? -26.77193 -13.64243 20.36301  1.000 56.85558 ? 240 GLU A OE1 1 
ATOM   1856 O OE2 . GLU A 1 240 ? -25.72219 -12.42282 18.87088  1.000 47.83237 ? 240 GLU A OE2 1 
ATOM   1857 N N   . PRO A 1 241 ? -27.19823 -9.97508  23.29606  1.000 33.35831 ? 241 PRO A N   1 
ATOM   1858 C CA  . PRO A 1 241 ? -27.92630 -9.53828  24.48663  1.000 32.31747 ? 241 PRO A CA  1 
ATOM   1859 C C   . PRO A 1 241 ? -27.78067 -10.56945 25.58798  1.000 32.80425 ? 241 PRO A C   1 
ATOM   1860 O O   . PRO A 1 241 ? -27.76428 -11.77770 25.33378  1.000 31.35456 ? 241 PRO A O   1 
ATOM   1861 C CB  . PRO A 1 241 ? -29.37399 -9.42406  23.99992  1.000 35.20342 ? 241 PRO A CB  1 
ATOM   1862 C CG  . PRO A 1 241 ? -29.26244 -9.28415  22.51717  1.000 35.96013 ? 241 PRO A CG  1 
ATOM   1863 C CD  . PRO A 1 241 ? -28.10039 -10.16570 22.15291  1.000 36.15400 ? 241 PRO A CD  1 
ATOM   1864 N N   . LEU A 1 242 ? -27.63346 -10.07827 26.81466  1.000 30.71131 ? 242 LEU A N   1 
ATOM   1865 C CA  . LEU A 1 242 ? -27.46808 -10.94466 27.97123  1.000 30.36472 ? 242 LEU A CA  1 
ATOM   1866 C C   . LEU A 1 242 ? -28.82638 -11.15793 28.62692  1.000 33.03482 ? 242 LEU A C   1 
ATOM   1867 O O   . LEU A 1 242 ? -29.56193 -10.19490 28.87413  1.000 33.21347 ? 242 LEU A O   1 
ATOM   1868 C CB  . LEU A 1 242 ? -26.48842 -10.33094 28.96521  1.000 24.41637 ? 242 LEU A CB  1 
ATOM   1869 C CG  . LEU A 1 242 ? -26.01364 -11.27419 30.07472  1.000 30.62870 ? 242 LEU A CG  1 
ATOM   1870 C CD1 . LEU A 1 242 ? -24.82846 -12.12607 29.59543  1.000 28.13798 ? 242 LEU A CD1 1 
ATOM   1871 C CD2 . LEU A 1 242 ? -25.64569 -10.48172 31.29293  1.000 30.34503 ? 242 LEU A CD2 1 
ATOM   1872 N N   . THR A 1 243 ? -29.16080 -12.41498 28.88369  1.000 27.54189 ? 243 THR A N   1 
ATOM   1873 C CA  . THR A 1 243 ? -30.43965 -12.80699 29.45685  1.000 34.81300 ? 243 THR A CA  1 
ATOM   1874 C C   . THR A 1 243 ? -30.27348 -13.30095 30.88589  1.000 34.75512 ? 243 THR A C   1 
ATOM   1875 O O   . THR A 1 243 ? -29.16433 -13.51780 31.38119  1.000 25.77770 ? 243 THR A O   1 
ATOM   1876 C CB  . THR A 1 243 ? -31.08070 -13.90765 28.62892  1.000 29.41472 ? 243 THR A CB  1 
ATOM   1877 O OG1 . THR A 1 243 ? -30.31839 -15.09876 28.78642  1.000 32.48092 ? 243 THR A OG1 1 
ATOM   1878 C CG2 . THR A 1 243 ? -31.09724 -13.51876 27.16126  1.000 35.97091 ? 243 THR A CG2 1 
ATOM   1879 N N   . GLN A 1 244 ? -31.41517 -13.51246 31.54124  1.000 35.77544 ? 244 GLN A N   1 
ATOM   1880 C CA  . GLN A 1 244 ? -31.38487 -14.02004 32.90633  1.000 33.66890 ? 244 GLN A CA  1 
ATOM   1881 C C   . GLN A 1 244 ? -30.87229 -15.45381 32.95279  1.000 31.49835 ? 244 GLN A C   1 
ATOM   1882 O O   . GLN A 1 244 ? -30.21743 -15.84253 33.92753  1.000 29.34194 ? 244 GLN A O   1 
ATOM   1883 C CB  . GLN A 1 244 ? -32.77739 -13.92582 33.53874  1.000 27.80322 ? 244 GLN A CB  1 
ATOM   1884 C CG  . GLN A 1 244 ? -32.79456 -14.30177 35.02493  1.000 29.62392 ? 244 GLN A CG  1 
ATOM   1885 C CD  . GLN A 1 244 ? -31.94531 -13.36685 35.86246  1.000 33.41322 ? 244 GLN A CD  1 
ATOM   1886 O OE1 . GLN A 1 244 ? -31.99006 -12.14748 35.68200  1.000 49.10005 ? 244 GLN A OE1 1 
ATOM   1887 N NE2 . GLN A 1 244 ? -31.15393 -13.92683 36.76572  1.000 34.01949 ? 244 GLN A NE2 1 
ATOM   1888 N N   . ASP A 1 245 ? -31.16021 -16.25922 31.92545  1.000 26.67526 ? 245 ASP A N   1 
ATOM   1889 C CA  . ASP A 1 245 ? -30.52790 -17.57700 31.84511  1.000 33.01092 ? 245 ASP A CA  1 
ATOM   1890 C C   . ASP A 1 245 ? -29.00996 -17.46190 31.88530  1.000 28.22593 ? 245 ASP A C   1 
ATOM   1891 O O   . ASP A 1 245 ? -28.33420 -18.28782 32.50848  1.000 32.97715 ? 245 ASP A O   1 
ATOM   1892 C CB  . ASP A 1 245 ? -30.96174 -18.31249 30.57687  1.000 33.85714 ? 245 ASP A CB  1 
ATOM   1893 C CG  . ASP A 1 245 ? -32.33418 -18.92257 30.70550  1.000 41.69193 ? 245 ASP A CG  1 
ATOM   1894 O OD1 . ASP A 1 245 ? -32.96129 -18.70968 31.75603  1.000 42.37635 ? 245 ASP A OD1 1 
ATOM   1895 O OD2 . ASP A 1 245 ? -32.78832 -19.60539 29.76502  1.000 45.54073 ? 245 ASP A OD2 1 
ATOM   1896 N N   . HIS A 1 246 ? -28.45680 -16.44401 31.22027  1.000 34.16411 ? 246 HIS A N   1 
ATOM   1897 C CA  . HIS A 1 246 ? -27.01024 -16.23873 31.23514  1.000 31.06216 ? 246 HIS A CA  1 
ATOM   1898 C C   . HIS A 1 246 ? -26.52333 -15.83638 32.61608  1.000 28.99968 ? 246 HIS A C   1 
ATOM   1899 O O   . HIS A 1 246 ? -25.49555 -16.34289 33.08644  1.000 29.69749 ? 246 HIS A O   1 
ATOM   1900 C CB  . HIS A 1 246 ? -26.61245 -15.16494 30.23182  1.000 26.04135 ? 246 HIS A CB  1 
ATOM   1901 C CG  . HIS A 1 246 ? -26.82165 -15.55721 28.80380  1.000 30.36696 ? 246 HIS A CG  1 
ATOM   1902 N ND1 . HIS A 1 246 ? -27.20347 -14.65485 27.83707  1.000 31.40175 ? 246 HIS A ND1 1 
ATOM   1903 C CD2 . HIS A 1 246 ? -26.69623 -16.75010 28.17893  1.000 29.30936 ? 246 HIS A CD2 1 
ATOM   1904 C CE1 . HIS A 1 246 ? -27.30232 -15.27418 26.67372  1.000 35.22242 ? 246 HIS A CE1 1 
ATOM   1905 N NE2 . HIS A 1 246 ? -26.99140 -16.54570 26.85246  1.000 38.35928 ? 246 HIS A NE2 1 
ATOM   1906 N N   . VAL A 1 247 ? -27.21769 -14.88723 33.25846  1.000 29.34552 ? 247 VAL A N   1 
ATOM   1907 C CA  . VAL A 1 247 ? -26.88266 -14.53462 34.63589  1.000 27.65594 ? 247 VAL A CA  1 
ATOM   1908 C C   . VAL A 1 247 ? -26.86346 -15.78252 35.51058  1.000 27.28215 ? 247 VAL A C   1 
ATOM   1909 O O   . VAL A 1 247 ? -25.95425 -15.97432 36.32790  1.000 28.77886 ? 247 VAL A O   1 
ATOM   1910 C CB  . VAL A 1 247 ? -27.86866 -13.48653 35.18173  1.000 30.20284 ? 247 VAL A CB  1 
ATOM   1911 C CG1 . VAL A 1 247 ? -27.55957 -13.19687 36.65052  1.000 25.39614 ? 247 VAL A CG1 1 
ATOM   1912 C CG2 . VAL A 1 247 ? -27.79964 -12.23163 34.36038  1.000 28.30297 ? 247 VAL A CG2 1 
ATOM   1913 N N   . ASP A 1 248 ? -27.86430 -16.65019 35.35561  1.000 27.66814 ? 248 ASP A N   1 
ATOM   1914 C CA  . ASP A 1 248 ? -27.92582 -17.85815 36.17262  1.000 28.62386 ? 248 ASP A CA  1 
ATOM   1915 C C   . ASP A 1 248 ? -26.74842 -18.77622 35.88756  1.000 30.65036 ? 248 ASP A C   1 
ATOM   1916 O O   . ASP A 1 248 ? -26.16055 -19.34724 36.81501  1.000 28.27868 ? 248 ASP A O   1 
ATOM   1917 C CB  . ASP A 1 248 ? -29.23129 -18.60940 35.92609  1.000 33.58501 ? 248 ASP A CB  1 
ATOM   1918 C CG  . ASP A 1 248 ? -30.45334 -17.82030 36.35434  1.000 35.22482 ? 248 ASP A CG  1 
ATOM   1919 O OD1 . ASP A 1 248 ? -30.30994 -16.88979 37.17199  1.000 41.26975 ? 248 ASP A OD1 1 
ATOM   1920 O OD2 . ASP A 1 248 ? -31.55937 -18.13403 35.86079  1.000 38.55303 ? 248 ASP A OD2 1 
ATOM   1921 N N   . ILE A 1 249 ? -26.39715 -18.94347 34.61004  1.000 27.12534 ? 249 ILE A N   1 
ATOM   1922 C CA  . ILE A 1 249 ? -25.28097 -19.82122 34.27006  1.000 27.92716 ? 249 ILE A CA  1 
ATOM   1923 C C   . ILE A 1 249 ? -24.00296 -19.31997 34.92594  1.000 27.32865 ? 249 ILE A C   1 
ATOM   1924 O O   . ILE A 1 249 ? -23.14161 -20.11585 35.32406  1.000 32.63410 ? 249 ILE A O   1 
ATOM   1925 C CB  . ILE A 1 249 ? -25.15614 -19.93331 32.73755  1.000 32.01317 ? 249 ILE A CB  1 
ATOM   1926 C CG1 . ILE A 1 249 ? -26.38597 -20.63865 32.15961  1.000 28.14195 ? 249 ILE A CG1 1 
ATOM   1927 C CG2 . ILE A 1 249 ? -23.92373 -20.70853 32.35878  1.000 40.38928 ? 249 ILE A CG2 1 
ATOM   1928 C CD1 . ILE A 1 249 ? -26.57687 -20.43333 30.66155  1.000 33.78429 ? 249 ILE A CD1 1 
ATOM   1929 N N   . LEU A 1 250 ? -23.88280 -18.00483 35.10616  1.000 28.56197 ? 250 LEU A N   1 
ATOM   1930 C CA  . LEU A 1 250 ? -22.70117 -17.41197 35.72445  1.000 34.23385 ? 250 LEU A CA  1 
ATOM   1931 C C   . LEU A 1 250 ? -22.70814 -17.50074 37.25433  1.000 30.89720 ? 250 LEU A C   1 
ATOM   1932 O O   . LEU A 1 250 ? -21.72625 -17.10049 37.88905  1.000 30.21036 ? 250 LEU A O   1 
ATOM   1933 C CB  . LEU A 1 250 ? -22.56994 -15.95101 35.27494  1.000 25.90341 ? 250 LEU A CB  1 
ATOM   1934 C CG  . LEU A 1 250 ? -22.19614 -15.77155 33.78780  1.000 25.39560 ? 250 LEU A CG  1 
ATOM   1935 C CD1 . LEU A 1 250 ? -22.34651 -14.33849 33.29690  1.000 24.80506 ? 250 LEU A CD1 1 
ATOM   1936 C CD2 . LEU A 1 250 ? -20.75634 -16.23581 33.55914  1.000 24.58100 ? 250 LEU A CD2 1 
ATOM   1937 N N   . GLY A 1 251 ? -23.76839 -18.03267 37.85068  1.000 28.45380 ? 251 GLY A N   1 
ATOM   1938 C CA  . GLY A 1 251 ? -23.90804 -18.09017 39.28880  1.000 30.99558 ? 251 GLY A CA  1 
ATOM   1939 C C   . GLY A 1 251 ? -22.73166 -18.67416 40.05563  1.000 27.22286 ? 251 GLY A C   1 
ATOM   1940 O O   . GLY A 1 251 ? -22.25075 -18.07091 41.01449  1.000 32.36646 ? 251 GLY A O   1 
ATOM   1941 N N   . PRO A 1 252 ? -22.25133 -19.85975 39.66949  1.000 30.71022 ? 252 PRO A N   1 
ATOM   1942 C CA  . PRO A 1 252 ? -21.11805 -20.43972 40.41102  1.000 33.51398 ? 252 PRO A CA  1 
ATOM   1943 C C   . PRO A 1 252 ? -19.86475 -19.58530 40.38300  1.000 33.70553 ? 252 PRO A C   1 
ATOM   1944 O O   . PRO A 1 252 ? -19.16191 -19.51036 41.39633  1.000 32.75173 ? 252 PRO A O   1 
ATOM   1945 C CB  . PRO A 1 252 ? -20.92417 -21.79165 39.72419  1.000 34.68681 ? 252 PRO A CB  1 
ATOM   1946 C CG  . PRO A 1 252 ? -22.29819 -22.15700 39.29828  1.000 36.38578 ? 252 PRO A CG  1 
ATOM   1947 C CD  . PRO A 1 252 ? -22.88349 -20.86081 38.79633  1.000 34.36296 ? 252 PRO A CD  1 
ATOM   1948 N N   . LEU A 1 253 ? -19.57308 -18.91462 39.26218  1.000 28.85526 ? 253 LEU A N   1 
ATOM   1949 C CA  . LEU A 1 253 ? -18.40232 -18.04660 39.20897  1.000 24.96352 ? 253 LEU A CA  1 
ATOM   1950 C C   . LEU A 1 253 ? -18.61810 -16.79048 40.02896  1.000 31.26083 ? 253 LEU A C   1 
ATOM   1951 O O   . LEU A 1 253 ? -17.68582 -16.27680 40.66734  1.000 30.50379 ? 253 LEU A O   1 
ATOM   1952 C CB  . LEU A 1 253 ? -18.08767 -17.68612 37.75553  1.000 31.07884 ? 253 LEU A CB  1 
ATOM   1953 C CG  . LEU A 1 253 ? -17.53037 -18.82334 36.89647  1.000 25.62611 ? 253 LEU A CG  1 
ATOM   1954 C CD1 . LEU A 1 253 ? -17.52070 -18.41408 35.42922  1.000 27.18215 ? 253 LEU A CD1 1 
ATOM   1955 C CD2 . LEU A 1 253 ? -16.13324 -19.15520 37.36605  1.000 28.25413 ? 253 LEU A CD2 1 
ATOM   1956 N N   . SER A 1 254 ? -19.84440 -16.27074 40.00322  1.000 31.89991 ? 254 SER A N   1 
ATOM   1957 C CA  . SER A 1 254 ? -20.20372 -15.18403 40.89295  1.000 30.14624 ? 254 SER A CA  1 
ATOM   1958 C C   . SER A 1 254 ? -19.96256 -15.57120 42.34461  1.000 28.15380 ? 254 SER A C   1 
ATOM   1959 O O   . SER A 1 254 ? -19.40179 -14.78567 43.11719  1.000 35.51405 ? 254 SER A O   1 
ATOM   1960 C CB  . SER A 1 254 ? -21.66491 -14.80970 40.67105  1.000 32.45406 ? 254 SER A CB  1 
ATOM   1961 O OG  . SER A 1 254 ? -22.02098 -13.77265 41.54537  1.000 32.18722 ? 254 SER A OG  1 
ATOM   1962 N N   . ALA A 1 255 ? -20.35579 -16.78978 42.72639  1.000 27.77590 ? 255 ALA A N   1 
ATOM   1963 C CA  . ALA A 1 255 ? -20.25210 -17.20746 44.12395  1.000 27.99084 ? 255 ALA A CA  1 
ATOM   1964 C C   . ALA A 1 255 ? -18.79722 -17.35916 44.55208  1.000 38.21010 ? 255 ALA A C   1 
ATOM   1965 O O   . ALA A 1 255 ? -18.39151 -16.85831 45.60950  1.000 35.66211 ? 255 ALA A O   1 
ATOM   1966 C CB  . ALA A 1 255 ? -21.01461 -18.51830 44.32459  1.000 27.25503 ? 255 ALA A CB  1 
ATOM   1967 N N   . GLN A 1 256 ? -17.99534 -18.03854 43.73562  1.000 35.86636 ? 256 GLN A N   1 
ATOM   1968 C CA  . GLN A 1 256 ? -16.57942 -18.21352 44.04952  1.000 37.19534 ? 256 GLN A CA  1 
ATOM   1969 C C   . GLN A 1 256 ? -15.86122 -16.87660 44.22189  1.000 38.61603 ? 256 GLN A C   1 
ATOM   1970 O O   . GLN A 1 256 ? -15.02107 -16.72456 45.11785  1.000 37.14093 ? 256 GLN A O   1 
ATOM   1971 C CB  . GLN A 1 256 ? -15.91835 -19.03605 42.94899  1.000 40.50597 ? 256 GLN A CB  1 
ATOM   1972 C CG  . GLN A 1 256 ? -14.47863 -19.39957 43.21235  1.000 45.90073 ? 256 GLN A CG  1 
ATOM   1973 C CD  . GLN A 1 256 ? -13.88757 -20.19085 42.06535  1.000 44.80496 ? 256 GLN A CD  1 
ATOM   1974 O OE1 . GLN A 1 256 ? -14.59191 -20.93875 41.38202  1.000 46.41135 ? 256 GLN A OE1 1 
ATOM   1975 N NE2 . GLN A 1 256 ? -12.59426 -20.02242 41.83732  1.000 50.04680 ? 256 GLN A NE2 1 
ATOM   1976 N N   . THR A 1 257 ? -16.16100 -15.89428 43.37595  1.000 29.63436 ? 257 THR A N   1 
ATOM   1977 C CA  . THR A 1 257 ? -15.40786 -14.64791 43.43842  1.000 33.86924 ? 257 THR A CA  1 
ATOM   1978 C C   . THR A 1 257 ? -16.04764 -13.59172 44.32955  1.000 32.05039 ? 257 THR A C   1 
ATOM   1979 O O   . THR A 1 257 ? -15.39373 -12.59194 44.63508  1.000 30.03212 ? 257 THR A O   1 
ATOM   1980 C CB  . THR A 1 257 ? -15.20329 -14.05105 42.03555  1.000 37.32866 ? 257 THR A CB  1 
ATOM   1981 O OG1 . THR A 1 257 ? -16.45959 -13.61831 41.49958  1.000 32.19673 ? 257 THR A OG1 1 
ATOM   1982 C CG2 . THR A 1 257 ? -14.56306 -15.08007 41.09227  1.000 31.04566 ? 257 THR A CG2 1 
ATOM   1983 N N   . GLY A 1 258 ? -17.29771 -13.77136 44.73889  1.000 31.46650 ? 258 GLY A N   1 
ATOM   1984 C CA  . GLY A 1 258 ? -17.97658 -12.70191 45.43812  1.000 33.16599 ? 258 GLY A CA  1 
ATOM   1985 C C   . GLY A 1 258 ? -18.21617 -11.45701 44.61599  1.000 34.40836 ? 258 GLY A C   1 
ATOM   1986 O O   . GLY A 1 258 ? -18.41135 -10.38327 45.18221  1.000 32.10354 ? 258 GLY A O   1 
ATOM   1987 N N   . ILE A 1 259 ? -18.19282 -11.55372 43.28872  1.000 31.17219 ? 259 ILE A N   1 
ATOM   1988 C CA  . ILE A 1 259 ? -18.48250 -10.41420 42.42999  1.000 30.83296 ? 259 ILE A CA  1 
ATOM   1989 C C   . ILE A 1 259 ? -19.80614 -10.67751 41.74274  1.000 34.10401 ? 259 ILE A C   1 
ATOM   1990 O O   . ILE A 1 259 ? -19.92398 -11.61365 40.94019  1.000 34.80862 ? 259 ILE A O   1 
ATOM   1991 C CB  . ILE A 1 259 ? -17.38181 -10.16195 41.39186  1.000 30.03324 ? 259 ILE A CB  1 
ATOM   1992 C CG1 . ILE A 1 259 ? -16.15202 -9.53616  42.04032  1.000 33.11721 ? 259 ILE A CG1 1 
ATOM   1993 C CG2 . ILE A 1 259 ? -17.90467 -9.20966  40.32953  1.000 30.28181 ? 259 ILE A CG2 1 
ATOM   1994 C CD1 . ILE A 1 259 ? -14.90738 -9.67218  41.19151  1.000 34.10659 ? 259 ILE A CD1 1 
ATOM   1995 N N   . ALA A 1 260 ? -20.79768 -9.85249  42.05759  1.000 34.65651 ? 260 ALA A N   1 
ATOM   1996 C CA  . ALA A 1 260 ? -22.11054 -9.99671  41.45461  1.000 28.95111 ? 260 ALA A CA  1 
ATOM   1997 C C   . ALA A 1 260 ? -22.00720 -9.95051  39.93386  1.000 25.63077 ? 260 ALA A C   1 
ATOM   1998 O O   . ALA A 1 260 ? -21.17583 -9.23620  39.36496  1.000 27.16028 ? 260 ALA A O   1 
ATOM   1999 C CB  . ALA A 1 260 ? -23.04172 -8.89625  41.95665  1.000 35.56989 ? 260 ALA A CB  1 
ATOM   2000 N N   . VAL A 1 261 ? -22.84075 -10.75242 39.27937  1.000 22.69361 ? 261 VAL A N   1 
ATOM   2001 C CA  . VAL A 1 261 ? -22.87192 -10.74114 37.81749  1.000 29.47824 ? 261 VAL A CA  1 
ATOM   2002 C C   . VAL A 1 261 ? -23.06131 -9.32475  37.30188  1.000 29.15247 ? 261 VAL A C   1 
ATOM   2003 O O   . VAL A 1 261 ? -22.38470 -8.89463  36.36093  1.000 25.33220 ? 261 VAL A O   1 
ATOM   2004 C CB  . VAL A 1 261 ? -23.97103 -11.68380 37.29323  1.000 29.65655 ? 261 VAL A CB  1 
ATOM   2005 C CG1 . VAL A 1 261 ? -24.01639 -11.64036 35.78850  1.000 29.30925 ? 261 VAL A CG1 1 
ATOM   2006 C CG2 . VAL A 1 261 ? -23.72052 -13.11647 37.77671  1.000 34.07013 ? 261 VAL A CG2 1 
ATOM   2007 N N   . LEU A 1 262 ? -23.97335 -8.56149  37.91645  1.000 24.96627 ? 262 LEU A N   1 
ATOM   2008 C CA  . LEU A 1 262 ? -24.23410 -7.23282  37.38056  1.000 23.87430 ? 262 LEU A CA  1 
ATOM   2009 C C   . LEU A 1 262 ? -23.05020 -6.29421  37.59368  1.000 27.28950 ? 262 LEU A C   1 
ATOM   2010 O O   . LEU A 1 262 ? -22.81480 -5.40376  36.76642  1.000 30.06434 ? 262 LEU A O   1 
ATOM   2011 C CB  . LEU A 1 262 ? -25.52161 -6.66156  37.97939  1.000 26.46082 ? 262 LEU A CB  1 
ATOM   2012 C CG  . LEU A 1 262 ? -26.79695 -7.28945  37.39978  1.000 27.69163 ? 262 LEU A CG  1 
ATOM   2013 C CD1 . LEU A 1 262 ? -28.04153 -6.62752  37.97138  1.000 29.69730 ? 262 LEU A CD1 1 
ATOM   2014 C CD2 . LEU A 1 262 ? -26.82426 -7.22501  35.85509  1.000 25.05212 ? 262 LEU A CD2 1 
ATOM   2015 N N   . ASP A 1 263 ? -22.27759 -6.48795  38.66409  1.000 25.62211 ? 263 ASP A N   1 
ATOM   2016 C CA  . ASP A 1 263 ? -21.07604 -5.67732  38.82988  1.000 26.13849 ? 263 ASP A CA  1 
ATOM   2017 C C   . ASP A 1 263 ? -20.05197 -6.00202  37.75231  1.000 27.56538 ? 263 ASP A C   1 
ATOM   2018 O O   . ASP A 1 263 ? -19.37872 -5.10182  37.24175  1.000 32.65971 ? 263 ASP A O   1 
ATOM   2019 C CB  . ASP A 1 263 ? -20.47650 -5.87718  40.22629  1.000 27.31793 ? 263 ASP A CB  1 
ATOM   2020 C CG  . ASP A 1 263 ? -21.40542 -5.38457  41.33594  1.000 33.33775 ? 263 ASP A CG  1 
ATOM   2021 O OD1 . ASP A 1 263 ? -22.47459 -4.82941  41.01141  1.000 33.67214 ? 263 ASP A OD1 1 
ATOM   2022 O OD2 . ASP A 1 263 ? -21.06688 -5.54136  42.52930  1.000 33.20932 ? 263 ASP A OD2 1 
ATOM   2023 N N   . MET A 1 264 ? -19.91076 -7.28253  37.40202  1.000 30.34676 ? 264 MET A N   1 
ATOM   2024 C CA  . MET A 1 264 ? -19.00243 -7.63604  36.31761  1.000 30.60810 ? 264 MET A CA  1 
ATOM   2025 C C   . MET A 1 264 ? -19.48505 -7.03035  35.00003  1.000 27.82951 ? 264 MET A C   1 
ATOM   2026 O O   . MET A 1 264 ? -18.68142 -6.51678  34.21403  1.000 36.96459 ? 264 MET A O   1 
ATOM   2027 C CB  . MET A 1 264 ? -18.86293 -9.16322  36.21773  1.000 26.11591 ? 264 MET A CB  1 
ATOM   2028 C CG  . MET A 1 264 ? -17.67835 -9.60526  35.35163  1.000 27.16353 ? 264 MET A CG  1 
ATOM   2029 S SD  . MET A 1 264 ? -16.08647 -9.08361  36.05437  1.000 31.44862 ? 264 MET A SD  1 
ATOM   2030 C CE  . MET A 1 264 ? -15.72262 -10.47493 37.09887  1.000 26.28430 ? 264 MET A CE  1 
ATOM   2031 N N   . CYS A 1 265 ? -20.79781 -7.05384  34.75230  1.000 28.27082 ? 265 CYS A N   1 
ATOM   2032 C CA  . CYS A 1 265 ? -21.33286 -6.38451  33.56471  1.000 27.39514 ? 265 CYS A CA  1 
ATOM   2033 C C   . CYS A 1 265 ? -20.92325 -4.91474  33.51574  1.000 26.73626 ? 265 CYS A C   1 
ATOM   2034 O O   . CYS A 1 265 ? -20.61480 -4.37954  32.44155  1.000 28.00541 ? 265 CYS A O   1 
ATOM   2035 C CB  . CYS A 1 265 ? -22.85201 -6.50421  33.52746  1.000 27.61660 ? 265 CYS A CB  1 
ATOM   2036 S SG  . CYS A 1 265 ? -23.49334 -8.15764  33.23848  1.000 28.84054 ? 265 CYS A SG  1 
ATOM   2037 N N   . ALA A 1 266 ? -20.90654 -4.24193  34.67066  1.000 29.88521 ? 266 ALA A N   1 
ATOM   2038 C CA  . ALA A 1 266 ? -20.50840 -2.83834  34.68153  1.000 22.69113 ? 266 ALA A CA  1 
ATOM   2039 C C   . ALA A 1 266 ? -19.02420 -2.67241  34.39475  1.000 25.00008 ? 266 ALA A C   1 
ATOM   2040 O O   . ALA A 1 266 ? -18.62194 -1.66418  33.81156  1.000 29.47944 ? 266 ALA A O   1 
ATOM   2041 C CB  . ALA A 1 266 ? -20.85069 -2.20180  36.02226  1.000 29.95071 ? 266 ALA A CB  1 
ATOM   2042 N N   . SER A 1 267 ? -18.19919 -3.64410  34.79294  1.000 32.39614 ? 267 SER A N   1 
ATOM   2043 C CA  . SER A 1 267 ? -16.79581 -3.62177  34.39261  1.000 34.62115 ? 267 SER A CA  1 
ATOM   2044 C C   . SER A 1 267 ? -16.65338 -3.78522  32.88653  1.000 30.28257 ? 267 SER A C   1 
ATOM   2045 O O   . SER A 1 267 ? -15.84602 -3.09246  32.25085  1.000 28.56808 ? 267 SER A O   1 
ATOM   2046 C CB  . SER A 1 267 ? -16.02471 -4.71801  35.12470  1.000 32.16713 ? 267 SER A CB  1 
ATOM   2047 O OG  . SER A 1 267 ? -15.67177 -4.30477  36.43384  1.000 41.11746 ? 267 SER A OG  1 
ATOM   2048 N N   . LEU A 1 268 ? -17.41799 -4.70931  32.30248  1.000 28.53905 ? 268 LEU A N   1 
ATOM   2049 C CA  . LEU A 1 268 ? -17.34764 -4.92730  30.86172  1.000 23.50313 ? 268 LEU A CA  1 
ATOM   2050 C C   . LEU A 1 268 ? -17.84830 -3.70637  30.10013  1.000 26.70828 ? 268 LEU A C   1 
ATOM   2051 O O   . LEU A 1 268 ? -17.24856 -3.30081  29.09568  1.000 31.90048 ? 268 LEU A O   1 
ATOM   2052 C CB  . LEU A 1 268 ? -18.15573 -6.16658  30.48420  1.000 25.52893 ? 268 LEU A CB  1 
ATOM   2053 C CG  . LEU A 1 268 ? -18.29830 -6.50145  28.99776  1.000 23.16265 ? 268 LEU A CG  1 
ATOM   2054 C CD1 . LEU A 1 268 ? -16.93508 -6.66826  28.33022  1.000 25.90718 ? 268 LEU A CD1 1 
ATOM   2055 C CD2 . LEU A 1 268 ? -19.09080 -7.79045  28.87804  1.000 29.34850 ? 268 LEU A CD2 1 
ATOM   2056 N N   . LYS A 1 269 ? -18.94208 -3.10229  30.57440  1.000 27.78341 ? 269 LYS A N   1 
ATOM   2057 C CA  . LYS A 1 269 ? -19.43444 -1.85419  29.99107  1.000 27.37934 ? 269 LYS A CA  1 
ATOM   2058 C C   . LYS A 1 269 ? -18.34355 -0.79465  29.93852  1.000 31.77194 ? 269 LYS A C   1 
ATOM   2059 O O   . LYS A 1 269 ? -18.12629 -0.16096  28.89672  1.000 32.30147 ? 269 LYS A O   1 
ATOM   2060 C CB  . LYS A 1 269 ? -20.62994 -1.33624  30.78772  1.000 26.13783 ? 269 LYS A CB  1 
ATOM   2061 C CG  . LYS A 1 269 ? -21.08450 0.06382   30.38005  1.000 31.28418 ? 269 LYS A CG  1 
ATOM   2062 C CD  . LYS A 1 269 ? -22.31983 0.47902   31.17218  1.000 31.72555 ? 269 LYS A CD  1 
ATOM   2063 C CE  . LYS A 1 269 ? -22.77362 1.88694   30.78520  1.000 37.89224 ? 269 LYS A CE  1 
ATOM   2064 N NZ  . LYS A 1 269 ? -23.92527 2.33859   31.62655  1.000 45.71534 ? 269 LYS A NZ  1 
ATOM   2065 N N   . GLU A 1 270 ? -17.65185 -0.57347  31.06067  1.000 28.16774 ? 270 GLU A N   1 
ATOM   2066 C CA  . GLU A 1 270 ? -16.56171 0.39209   31.04748  1.000 28.45678 ? 270 GLU A CA  1 
ATOM   2067 C C   . GLU A 1 270 ? -15.47572 -0.03934  30.07164  1.000 30.31090 ? 270 GLU A C   1 
ATOM   2068 O O   . GLU A 1 270 ? -14.85027 0.79866   29.41210  1.000 33.22184 ? 270 GLU A O   1 
ATOM   2069 C CB  . GLU A 1 270 ? -15.97991 0.55523   32.44832  1.000 33.26920 ? 270 GLU A CB  1 
ATOM   2070 C CG  . GLU A 1 270 ? -16.90922 1.26257   33.41798  1.000 36.60866 ? 270 GLU A CG  1 
ATOM   2071 C CD  . GLU A 1 270 ? -17.39558 2.58555   32.88013  1.000 43.96954 ? 270 GLU A CD  1 
ATOM   2072 O OE1 . GLU A 1 270 ? -16.54676 3.44110   32.53093  1.000 43.49561 ? 270 GLU A OE1 1 
ATOM   2073 O OE2 . GLU A 1 270 ? -18.62931 2.75224   32.78350  1.000 39.93047 ? 270 GLU A OE2 1 
ATOM   2074 N N   . LEU A 1 271 ? -15.23808 -1.34765  29.96560  1.000 31.01420 ? 271 LEU A N   1 
ATOM   2075 C CA  . LEU A 1 271 ? -14.21276 -1.82448  29.05022  1.000 30.79283 ? 271 LEU A CA  1 
ATOM   2076 C C   . LEU A 1 271 ? -14.62431 -1.59313  27.60502  1.000 30.05885 ? 271 LEU A C   1 
ATOM   2077 O O   . LEU A 1 271 ? -13.77867 -1.29839  26.75548  1.000 36.06895 ? 271 LEU A O   1 
ATOM   2078 C CB  . LEU A 1 271 ? -13.93297 -3.30170  29.29918  1.000 29.61430 ? 271 LEU A CB  1 
ATOM   2079 C CG  . LEU A 1 271 ? -13.00765 -3.68053  30.46165  1.000 31.90440 ? 271 LEU A CG  1 
ATOM   2080 C CD1 . LEU A 1 271 ? -12.91375 -5.18520  30.55049  1.000 26.99298 ? 271 LEU A CD1 1 
ATOM   2081 C CD2 . LEU A 1 271 ? -11.62741 -3.07567  30.27791  1.000 31.72480 ? 271 LEU A CD2 1 
ATOM   2082 N N   . LEU A 1 272 ? -15.91495 -1.72560  27.30266  1.000 29.60821 ? 272 LEU A N   1 
ATOM   2083 C CA  . LEU A 1 272 ? -16.35865 -1.50123  25.93008  1.000 32.92777 ? 272 LEU A CA  1 
ATOM   2084 C C   . LEU A 1 272 ? -16.34792 -0.02048  25.58440  1.000 40.91268 ? 272 LEU A C   1 
ATOM   2085 O O   . LEU A 1 272 ? -16.02269 0.35380   24.45125  1.000 38.46657 ? 272 LEU A O   1 
ATOM   2086 C CB  . LEU A 1 272 ? -17.75116 -2.08524  25.71503  1.000 27.62552 ? 272 LEU A CB  1 
ATOM   2087 C CG  . LEU A 1 272 ? -17.86192 -3.59956  25.82243  1.000 31.14872 ? 272 LEU A CG  1 
ATOM   2088 C CD1 . LEU A 1 272 ? -19.31939 -4.05735  25.88189  1.000 23.54963 ? 272 LEU A CD1 1 
ATOM   2089 C CD2 . LEU A 1 272 ? -17.13261 -4.23295  24.66121  1.000 33.48009 ? 272 LEU A CD2 1 
ATOM   2090 N N   . GLN A 1 273 ? -16.69113 0.83652   26.54936  1.000 35.42791 ? 273 GLN A N   1 
ATOM   2091 C CA  . GLN A 1 273 ? -16.75281 2.26939   26.28688  1.000 35.98446 ? 273 GLN A CA  1 
ATOM   2092 C C   . GLN A 1 273 ? -15.37821 2.92146   26.28630  1.000 41.52555 ? 273 GLN A C   1 
ATOM   2093 O O   . GLN A 1 273 ? -15.17670 3.92290   25.59102  1.000 34.94597 ? 273 GLN A O   1 
ATOM   2094 C CB  . GLN A 1 273 ? -17.65924 2.95198   27.31591  1.000 34.11575 ? 273 GLN A CB  1 
ATOM   2095 C CG  . GLN A 1 273 ? -19.13332 2.62626   27.11238  1.000 34.65280 ? 273 GLN A CG  1 
ATOM   2096 C CD  . GLN A 1 273 ? -20.01547 3.15028   28.22579  1.000 32.89556 ? 273 GLN A CD  1 
ATOM   2097 O OE1 . GLN A 1 273 ? -19.53040 3.57527   29.27205  1.000 39.97639 ? 273 GLN A OE1 1 
ATOM   2098 N NE2 . GLN A 1 273 ? -21.31794 3.10110   28.01361  1.000 39.83469 ? 273 GLN A NE2 1 
ATOM   2099 N N   . ASN A 1 274 ? -14.42364 2.38349   27.04089  1.000 36.26980 ? 274 ASN A N   1 
ATOM   2100 C CA  . ASN A 1 274 ? -13.14320 3.05004   27.21908  1.000 37.24482 ? 274 ASN A CA  1 
ATOM   2101 C C   . ASN A 1 274 ? -11.95363 2.29367   26.64936  1.000 42.42271 ? 274 ASN A C   1 
ATOM   2102 O O   . ASN A 1 274 ? -10.85432 2.85397   26.62018  1.000 43.25313 ? 274 ASN A O   1 
ATOM   2103 C CB  . ASN A 1 274 ? -12.89167 3.32220   28.71215  1.000 38.38116 ? 274 ASN A CB  1 
ATOM   2104 C CG  . ASN A 1 274 ? -13.95602 4.21814   29.32553  1.000 42.63371 ? 274 ASN A CG  1 
ATOM   2105 O OD1 . ASN A 1 274 ? -14.52976 3.90272   30.37043  1.000 53.75597 ? 274 ASN A OD1 1 
ATOM   2106 N ND2 . ASN A 1 274 ? -14.23740 5.33486   28.66535  1.000 50.39579 ? 274 ASN A ND2 1 
ATOM   2107 N N   . GLY A 1 275 ? -12.13082 1.05711   26.19274  1.000 44.93865 ? 275 GLY A N   1 
ATOM   2108 C CA  . GLY A 1 275 ? -11.01268 0.25177   25.73856  1.000 45.87828 ? 275 GLY A CA  1 
ATOM   2109 C C   . GLY A 1 275 ? -10.15693 -0.20392  26.90942  1.000 44.55954 ? 275 GLY A C   1 
ATOM   2110 O O   . GLY A 1 275 ? -10.41790 0.09936   28.07046  1.000 42.44110 ? 275 GLY A O   1 
ATOM   2111 N N   . MET A 1 276 ? -9.10768  -0.95259  26.58178  1.000 39.25394 ? 276 MET A N   1 
ATOM   2112 C CA  . MET A 1 276 ? -8.19864  -1.48484  27.58746  1.000 43.00362 ? 276 MET A CA  1 
ATOM   2113 C C   . MET A 1 276 ? -7.04171  -0.54127  27.91129  1.000 44.66746 ? 276 MET A C   1 
ATOM   2114 O O   . MET A 1 276 ? -6.25231  -0.83877  28.81737  1.000 41.51002 ? 276 MET A O   1 
ATOM   2115 C CB  . MET A 1 276 ? -7.66122  -2.84901  27.13175  1.000 45.53405 ? 276 MET A CB  1 
ATOM   2116 C CG  . MET A 1 276 ? -8.21547  -4.01880  27.94308  1.000 48.15570 ? 276 MET A CG  1 
ATOM   2117 S SD  . MET A 1 276 ? -8.18594  -5.62541  27.12407  1.000 51.94941 ? 276 MET A SD  1 
ATOM   2118 C CE  . MET A 1 276 ? -9.62512  -5.47448  26.09111  1.000 41.84824 ? 276 MET A CE  1 
ATOM   2119 N N   . ASN A 1 277 ? -6.93207  0.58799   27.21208  1.000 42.86104 ? 277 ASN A N   1 
ATOM   2120 C CA  . ASN A 1 277 ? -5.87697  1.56893   27.47291  1.000 49.06197 ? 277 ASN A CA  1 
ATOM   2121 C C   . ASN A 1 277 ? -4.49768  0.93005   27.37870  1.000 52.76834 ? 277 ASN A C   1 
ATOM   2122 O O   . ASN A 1 277 ? -3.61206  1.19731   28.19207  1.000 54.94864 ? 277 ASN A O   1 
ATOM   2123 C CB  . ASN A 1 277 ? -6.05970  2.23712   28.83615  1.000 49.00887 ? 277 ASN A CB  1 
ATOM   2124 C CG  . ASN A 1 277 ? -7.19296  3.23216   28.84412  1.000 55.90477 ? 277 ASN A CG  1 
ATOM   2125 O OD1 . ASN A 1 277 ? -7.16050  4.22144   28.11513  1.000 61.04866 ? 277 ASN A OD1 1 
ATOM   2126 N ND2 . ASN A 1 277 ? -8.20262  2.98206   29.67345  1.000 55.49945 ? 277 ASN A ND2 1 
ATOM   2127 N N   . GLY A 1 278 ? -4.32220  0.05805   26.38902  1.000 46.95933 ? 278 GLY A N   1 
ATOM   2128 C CA  . GLY A 1 278 ? -3.05494  -0.60731  26.19192  1.000 49.44378 ? 278 GLY A CA  1 
ATOM   2129 C C   . GLY A 1 278 ? -2.69088  -1.64746  27.22681  1.000 43.23778 ? 278 GLY A C   1 
ATOM   2130 O O   . GLY A 1 278 ? -1.57026  -2.16680  27.18580  1.000 49.46001 ? 278 GLY A O   1 
ATOM   2131 N N   . ARG A 1 279 ? -3.58457  -1.96839  28.15173  1.000 45.35630 ? 279 ARG A N   1 
ATOM   2132 C CA  . ARG A 1 279 ? -3.35119  -3.03429  29.11115  1.000 40.76168 ? 279 ARG A CA  1 
ATOM   2133 C C   . ARG A 1 279 ? -3.76230  -4.38246  28.52250  1.000 39.29271 ? 279 ARG A C   1 
ATOM   2134 O O   . ARG A 1 279 ? -4.32216  -4.47144  27.42645  1.000 37.08273 ? 279 ARG A O   1 
ATOM   2135 C CB  . ARG A 1 279 ? -4.11445  -2.75650  30.40624  1.000 43.24237 ? 279 ARG A CB  1 
ATOM   2136 C CG  . ARG A 1 279 ? -3.44113  -1.72499  31.28910  1.000 47.65112 ? 279 ARG A CG  1 
ATOM   2137 C CD  . ARG A 1 279 ? -4.24162  -1.44766  32.54945  1.000 52.36458 ? 279 ARG A CD  1 
ATOM   2138 N NE  . ARG A 1 279 ? -5.35797  -0.54558  32.29235  1.000 53.51768 ? 279 ARG A NE  1 
ATOM   2139 C CZ  . ARG A 1 279 ? -6.08971  0.02726   33.23929  1.000 57.51280 ? 279 ARG A CZ  1 
ATOM   2140 N NH1 . ARG A 1 279 ? -5.85691  -0.19759  34.52373  1.000 53.31031 ? 279 ARG A NH1 1 
ATOM   2141 N NH2 . ARG A 1 279 ? -7.08440  0.83974   32.88958  1.000 52.07097 ? 279 ARG A NH2 1 
ATOM   2142 N N   . THR A 1 280 ? -3.45843  -5.44543  29.25852  1.000 32.19116 ? 280 THR A N   1 
ATOM   2143 C CA  . THR A 1 280 ? -3.86790  -6.78780  28.88202  1.000 31.49507 ? 280 THR A CA  1 
ATOM   2144 C C   . THR A 1 280 ? -4.66837  -7.42417  30.00741  1.000 34.94372 ? 280 THR A C   1 
ATOM   2145 O O   . THR A 1 280 ? -4.51594  -7.07171  31.17907  1.000 34.09559 ? 280 THR A O   1 
ATOM   2146 C CB  . THR A 1 280 ? -2.66352  -7.68926  28.55689  1.000 43.57649 ? 280 THR A CB  1 
ATOM   2147 O OG1 . THR A 1 280 ? -1.79795  -7.77490  29.69981  1.000 38.54772 ? 280 THR A OG1 1 
ATOM   2148 C CG2 . THR A 1 280 ? -1.89619  -7.15235  27.37615  1.000 30.74046 ? 280 THR A CG2 1 
ATOM   2149 N N   . ILE A 1 281 ? -5.52052  -8.37694  29.63739  1.000 31.38979 ? 281 ILE A N   1 
ATOM   2150 C CA  . ILE A 1 281 ? -6.21557  -9.24215  30.58236  1.000 30.80479 ? 281 ILE A CA  1 
ATOM   2151 C C   . ILE A 1 281 ? -5.87272  -10.66968 30.20796  1.000 31.01276 ? 281 ILE A C   1 
ATOM   2152 O O   . ILE A 1 281 ? -6.17229  -11.10411 29.08806  1.000 32.60797 ? 281 ILE A O   1 
ATOM   2153 C CB  . ILE A 1 281 ? -7.73776  -9.04117  30.55042  1.000 28.60134 ? 281 ILE A CB  1 
ATOM   2154 C CG1 . ILE A 1 281 ? -8.12016  -7.63307  30.96718  1.000 29.61591 ? 281 ILE A CG1 1 
ATOM   2155 C CG2 . ILE A 1 281 ? -8.42441  -10.03239 31.46142  1.000 32.20460 ? 281 ILE A CG2 1 
ATOM   2156 C CD1 . ILE A 1 281 ? -9.59151  -7.37127  30.79837  1.000 25.88143 ? 281 ILE A CD1 1 
ATOM   2157 N N   . LEU A 1 282 ? -5.27313  -11.40427 31.14167  1.000 28.78943 ? 282 LEU A N   1 
ATOM   2158 C CA  . LEU A 1 282 ? -4.85373  -12.77422 30.89343  1.000 25.23534 ? 282 LEU A CA  1 
ATOM   2159 C C   . LEU A 1 282 ? -4.08485  -12.87895 29.57947  1.000 25.71571 ? 282 LEU A C   1 
ATOM   2160 O O   . LEU A 1 282 ? -4.35676  -13.74039 28.74016  1.000 29.00507 ? 282 LEU A O   1 
ATOM   2161 C CB  . LEU A 1 282 ? -6.05386  -13.72099 30.88514  1.000 27.76168 ? 282 LEU A CB  1 
ATOM   2162 C CG  . LEU A 1 282 ? -6.76781  -14.01040 32.19605  1.000 30.35428 ? 282 LEU A CG  1 
ATOM   2163 C CD1 . LEU A 1 282 ? -7.97128  -14.87303 31.88825  1.000 25.35253 ? 282 LEU A CD1 1 
ATOM   2164 C CD2 . LEU A 1 282 ? -5.82610  -14.71504 33.15796  1.000 31.17058 ? 282 LEU A CD2 1 
ATOM   2165 N N   . GLY A 1 283 ? -3.16812  -11.94063 29.37684  1.000 26.48868 ? 283 GLY A N   1 
ATOM   2166 C CA  . GLY A 1 283 ? -2.31196  -11.95663 28.20099  1.000 34.67964 ? 283 GLY A CA  1 
ATOM   2167 C C   . GLY A 1 283 ? -2.97941  -11.60925 26.88587  1.000 40.02572 ? 283 GLY A C   1 
ATOM   2168 O O   . GLY A 1 283 ? -2.41630  -11.89286 25.82035  1.000 36.48989 ? 283 GLY A O   1 
ATOM   2169 N N   . SER A 1 284 ? -4.16627  -11.00916 26.91765  1.000 33.04388 ? 284 SER A N   1 
ATOM   2170 C CA  . SER A 1 284 ? -4.86967  -10.62106 25.70570  1.000 31.20735 ? 284 SER A CA  1 
ATOM   2171 C C   . SER A 1 284 ? -5.18687  -9.13789  25.76799  1.000 35.08632 ? 284 SER A C   1 
ATOM   2172 O O   . SER A 1 284 ? -5.56143  -8.61865  26.82378  1.000 30.17140 ? 284 SER A O   1 
ATOM   2173 C CB  . SER A 1 284 ? -6.16320  -11.42101 25.50816  1.000 34.54066 ? 284 SER A CB  1 
ATOM   2174 O OG  . SER A 1 284 ? -6.88431  -10.94102 24.37872  1.000 33.78929 ? 284 SER A OG  1 
ATOM   2175 N N   . ALA A 1 285 ? -5.02869  -8.46599  24.62810  1.000 31.12976 ? 285 ALA A N   1 
ATOM   2176 C CA  . ALA A 1 285 ? -5.36195  -7.05906  24.48169  1.000 34.10602 ? 285 ALA A CA  1 
ATOM   2177 C C   . ALA A 1 285 ? -6.75987  -6.85037  23.92837  1.000 31.63651 ? 285 ALA A C   1 
ATOM   2178 O O   . ALA A 1 285 ? -7.11765  -5.71884  23.60512  1.000 38.57942 ? 285 ALA A O   1 
ATOM   2179 C CB  . ALA A 1 285 ? -4.33805  -6.35824  23.58262  1.000 31.55612 ? 285 ALA A CB  1 
ATOM   2180 N N   . LEU A 1 286 ? -7.55428  -7.91087  23.80347  1.000 30.96486 ? 286 LEU A N   1 
ATOM   2181 C CA  . LEU A 1 286 ? -8.94997  -7.77173  23.42068  1.000 30.38539 ? 286 LEU A CA  1 
ATOM   2182 C C   . LEU A 1 286 ? -9.79972  -8.70715  24.27457  1.000 32.53569 ? 286 LEU A C   1 
ATOM   2183 O O   . LEU A 1 286 ? -9.30082  -9.61373  24.94378  1.000 30.18873 ? 286 LEU A O   1 
ATOM   2184 C CB  . LEU A 1 286 ? -9.15225  -8.02236  21.91591  1.000 37.98794 ? 286 LEU A CB  1 
ATOM   2185 C CG  . LEU A 1 286 ? -8.44417  -9.20453  21.27134  1.000 37.16926 ? 286 LEU A CG  1 
ATOM   2186 C CD1 . LEU A 1 286 ? -9.24096  -10.47779 21.51305  1.000 41.27039 ? 286 LEU A CD1 1 
ATOM   2187 C CD2 . LEU A 1 286 ? -8.26588  -8.95629  19.78601  1.000 40.58605 ? 286 LEU A CD2 1 
ATOM   2188 N N   . LEU A 1 287 ? -11.10094 -8.46296  24.26227  1.000 29.12922 ? 287 LEU A N   1 
ATOM   2189 C CA  . LEU A 1 287 ? -12.02605 -9.22073  25.08612  1.000 24.79502 ? 287 LEU A CA  1 
ATOM   2190 C C   . LEU A 1 287 ? -12.24274 -10.60018 24.46568  1.000 29.06472 ? 287 LEU A C   1 
ATOM   2191 O O   . LEU A 1 287 ? -12.71372 -10.70593 23.33421  1.000 30.43337 ? 287 LEU A O   1 
ATOM   2192 C CB  . LEU A 1 287 ? -13.32496 -8.42933  25.21385  1.000 24.82415 ? 287 LEU A CB  1 
ATOM   2193 C CG  . LEU A 1 287 ? -12.98904 -7.05986  25.81956  1.000 30.85101 ? 287 LEU A CG  1 
ATOM   2194 C CD1 . LEU A 1 287 ? -14.15910 -6.07729  25.81880  1.000 30.45300 ? 287 LEU A CD1 1 
ATOM   2195 C CD2 . LEU A 1 287 ? -12.46386 -7.27836  27.23487  1.000 34.40474 ? 287 LEU A CD2 1 
ATOM   2196 N N   . GLU A 1 288 ? -11.90368 -11.65559 25.20149  1.000 26.80772 ? 288 GLU A N   1 
ATOM   2197 C CA  A GLU A 1 288 ? -11.95030 -13.01907 24.68630  0.500 27.50430 ? 288 GLU A CA  1 
ATOM   2198 C CA  B GLU A 1 288 ? -11.95122 -13.01471 24.67259  0.500 27.86175 ? 288 GLU A CA  1 
ATOM   2199 C C   . GLU A 1 288 ? -13.33035 -13.62621 24.89255  1.000 25.66242 ? 288 GLU A C   1 
ATOM   2200 O O   . GLU A 1 288 ? -13.86346 -13.60048 26.01093  1.000 25.99487 ? 288 GLU A O   1 
ATOM   2201 C CB  A GLU A 1 288 ? -10.90212 -13.88277 25.38580  0.500 29.52008 ? 288 GLU A CB  1 
ATOM   2202 C CB  B GLU A 1 288 ? -10.88135 -13.89195 25.32988  0.500 29.49751 ? 288 GLU A CB  1 
ATOM   2203 C CG  A GLU A 1 288 ? -11.01890 -15.35875 25.06575  0.500 29.05583 ? 288 GLU A CG  1 
ATOM   2204 C CG  B GLU A 1 288 ? -9.42879  -13.44409 25.11517  0.500 27.84157 ? 288 GLU A CG  1 
ATOM   2205 C CD  A GLU A 1 288 ? -10.63952 -15.65708 23.63693  0.500 27.98625 ? 288 GLU A CD  1 
ATOM   2206 C CD  B GLU A 1 288 ? -8.95946  -13.59698 23.67567  0.500 31.56155 ? 288 GLU A CD  1 
ATOM   2207 O OE1 A GLU A 1 288 ? -9.56334  -15.19049 23.20372  0.500 26.49129 ? 288 GLU A OE1 1 
ATOM   2208 O OE1 B GLU A 1 288 ? -9.52964  -14.42610 22.93828  0.500 26.53506 ? 288 GLU A OE1 1 
ATOM   2209 O OE2 A GLU A 1 288 ? -11.42250 -16.33249 22.94679  0.500 22.23493 ? 288 GLU A OE2 1 
ATOM   2210 O OE2 B GLU A 1 288 ? -8.01937  -12.88320 23.27809  0.500 27.77719 ? 288 GLU A OE2 1 
ATOM   2211 N N   . ASP A 1 289 ? -13.90266 -14.20723 23.82857  1.000 21.41624 ? 289 ASP A N   1 
ATOM   2212 C CA  . ASP A 1 289 ? -15.24296 -14.78604 23.94216  1.000 25.07249 ? 289 ASP A CA  1 
ATOM   2213 C C   . ASP A 1 289 ? -15.31781 -16.26445 23.55585  1.000 26.07606 ? 289 ASP A C   1 
ATOM   2214 O O   . ASP A 1 289 ? -16.41347 -16.77594 23.30394  1.000 29.37913 ? 289 ASP A O   1 
ATOM   2215 C CB  . ASP A 1 289 ? -16.25927 -13.95259 23.14483  1.000 24.23041 ? 289 ASP A CB  1 
ATOM   2216 C CG  . ASP A 1 289 ? -16.23507 -14.21213 21.63719  1.000 32.22773 ? 289 ASP A CG  1 
ATOM   2217 O OD1 . ASP A 1 289 ? -15.25229 -14.76654 21.10140  1.000 29.21915 ? 289 ASP A OD1 1 
ATOM   2218 O OD2 . ASP A 1 289 ? -17.23128 -13.82621 20.97679  1.000 28.97121 ? 289 ASP A OD2 1 
ATOM   2219 N N   . GLU A 1 290 ? -14.19782 -16.99201 23.56845  1.000 29.03229 ? 290 GLU A N   1 
ATOM   2220 C CA  . GLU A 1 290 ? -14.22015 -18.42150 23.27314  1.000 28.21628 ? 290 GLU A CA  1 
ATOM   2221 C C   . GLU A 1 290 ? -14.06486 -19.30930 24.50386  1.000 30.62681 ? 290 GLU A C   1 
ATOM   2222 O O   . GLU A 1 290 ? -13.63354 -20.45919 24.36572  1.000 23.82670 ? 290 GLU A O   1 
ATOM   2223 C CB  . GLU A 1 290 ? -13.13593 -18.77882 22.25746  1.000 32.16605 ? 290 GLU A CB  1 
ATOM   2224 C CG  . GLU A 1 290 ? -13.36173 -18.24276 20.89353  1.000 32.98857 ? 290 GLU A CG  1 
ATOM   2225 C CD  . GLU A 1 290 ? -12.49092 -18.96807 19.87147  1.000 40.59454 ? 290 GLU A CD  1 
ATOM   2226 O OE1 . GLU A 1 290 ? -11.28528 -19.21835 20.14330  1.000 42.49677 ? 290 GLU A OE1 1 
ATOM   2227 O OE2 . GLU A 1 290 ? -13.01985 -19.31877 18.81024  1.000 32.57032 ? 290 GLU A OE2 1 
ATOM   2228 N N   . PHE A 1 291 ? -14.43037 -18.82110 25.69705  1.000 25.94264 ? 291 PHE A N   1 
ATOM   2229 C CA  . PHE A 1 291 ? -14.52043 -19.64294 26.90178  1.000 24.02319 ? 291 PHE A CA  1 
ATOM   2230 C C   . PHE A 1 291 ? -15.94595 -19.57524 27.42001  1.000 24.59559 ? 291 PHE A C   1 
ATOM   2231 O O   . PHE A 1 291 ? -16.40352 -18.49573 27.79204  1.000 21.47652 ? 291 PHE A O   1 
ATOM   2232 C CB  . PHE A 1 291 ? -13.57359 -19.14295 27.99804  1.000 25.80781 ? 291 PHE A CB  1 
ATOM   2233 C CG  . PHE A 1 291 ? -12.11881 -19.28448 27.66266  1.000 25.39801 ? 291 PHE A CG  1 
ATOM   2234 C CD1 . PHE A 1 291 ? -11.47953 -20.50747 27.81696  1.000 26.13170 ? 291 PHE A CD1 1 
ATOM   2235 C CD2 . PHE A 1 291 ? -11.39882 -18.20123 27.20294  1.000 23.26832 ? 291 PHE A CD2 1 
ATOM   2236 C CE1 . PHE A 1 291 ? -10.13088 -20.63909 27.50267  1.000 34.43525 ? 291 PHE A CE1 1 
ATOM   2237 C CE2 . PHE A 1 291 ? -10.05972 -18.31681 26.89985  1.000 28.56917 ? 291 PHE A CE2 1 
ATOM   2238 C CZ  . PHE A 1 291 ? -9.42093  -19.54469 27.04854  1.000 26.29390 ? 291 PHE A CZ  1 
ATOM   2239 N N   . THR A 1 292 ? -16.63450 -20.71333 27.47347  1.000 21.38850 ? 292 THR A N   1 
ATOM   2240 C CA  . THR A 1 292 ? -17.94092 -20.73495 28.12727  1.000 26.44924 ? 292 THR A CA  1 
ATOM   2241 C C   . THR A 1 292 ? -17.77921 -20.67981 29.64009  1.000 23.17201 ? 292 THR A C   1 
ATOM   2242 O O   . THR A 1 292 ? -16.70267 -20.97198 30.17047  1.000 27.87156 ? 292 THR A O   1 
ATOM   2243 C CB  . THR A 1 292 ? -18.73245 -21.99773 27.78951  1.000 23.87786 ? 292 THR A CB  1 
ATOM   2244 O OG1 . THR A 1 292 ? -18.03102 -23.15031 28.26686  1.000 30.92365 ? 292 THR A OG1 1 
ATOM   2245 C CG2 . THR A 1 292 ? -18.98021 -22.11498 26.29069  1.000 23.64080 ? 292 THR A CG2 1 
ATOM   2246 N N   . PRO A 1 293 ? -18.85055 -20.33259 30.36540  1.000 31.35388 ? 293 PRO A N   1 
ATOM   2247 C CA  . PRO A 1 293 ? -18.80820 -20.49112 31.82778  1.000 20.94900 ? 293 PRO A CA  1 
ATOM   2248 C C   . PRO A 1 293 ? -18.33977 -21.87106 32.26835  1.000 30.62586 ? 293 PRO A C   1 
ATOM   2249 O O   . PRO A 1 293 ? -17.52231 -21.97736 33.19492  1.000 27.34470 ? 293 PRO A O   1 
ATOM   2250 C CB  . PRO A 1 293 ? -20.25859 -20.21745 32.23892  1.000 26.76137 ? 293 PRO A CB  1 
ATOM   2251 C CG  . PRO A 1 293 ? -20.73736 -19.23389 31.24128  1.000 22.59066 ? 293 PRO A CG  1 
ATOM   2252 C CD  . PRO A 1 293 ? -20.09705 -19.67277 29.92244  1.000 21.84120 ? 293 PRO A CD  1 
ATOM   2253 N N   . PHE A 1 294 ? -18.81431 -22.93458 31.61086  1.000 26.42014 ? 294 PHE A N   1 
ATOM   2254 C CA  . PHE A 1 294 ? -18.39905 -24.28309 31.99389  1.000 24.68829 ? 294 PHE A CA  1 
ATOM   2255 C C   . PHE A 1 294 ? -16.91713 -24.51388 31.71257  1.000 28.01964 ? 294 PHE A C   1 
ATOM   2256 O O   . PHE A 1 294 ? -16.23231 -25.17813 32.50151  1.000 28.23969 ? 294 PHE A O   1 
ATOM   2257 C CB  . PHE A 1 294 ? -19.26051 -25.32449 31.27390  1.000 33.63504 ? 294 PHE A CB  1 
ATOM   2258 C CG  . PHE A 1 294 ? -20.73451 -25.19238 31.56717  1.000 50.71134 ? 294 PHE A CG  1 
ATOM   2259 C CD1 . PHE A 1 294 ? -21.28580 -25.76344 32.70726  1.000 53.61090 ? 294 PHE A CD1 1 
ATOM   2260 C CD2 . PHE A 1 294 ? -21.56566 -24.48158 30.71234  1.000 62.61045 ? 294 PHE A CD2 1 
ATOM   2261 C CE1 . PHE A 1 294 ? -22.63898 -25.64176 32.98722  1.000 54.60116 ? 294 PHE A CE1 1 
ATOM   2262 C CE2 . PHE A 1 294 ? -22.92544 -24.35523 30.98958  1.000 70.51888 ? 294 PHE A CE2 1 
ATOM   2263 C CZ  . PHE A 1 294 ? -23.45928 -24.93834 32.13059  1.000 59.05131 ? 294 PHE A CZ  1 
ATOM   2264 N N   . ASP A 1 295 ? -16.40635 -23.97355 30.59572  1.000 25.42454 ? 295 ASP A N   1 
ATOM   2265 C CA  . ASP A 1 295 ? -14.97304 -24.04778 30.30615  1.000 30.81042 ? 295 ASP A CA  1 
ATOM   2266 C C   . ASP A 1 295 ? -14.15143 -23.44239 31.43373  1.000 35.84968 ? 295 ASP A C   1 
ATOM   2267 O O   . ASP A 1 295 ? -13.10660 -23.98479 31.81440  1.000 32.94090 ? 295 ASP A O   1 
ATOM   2268 C CB  . ASP A 1 295 ? -14.62799 -23.29216 29.02446  1.000 25.74742 ? 295 ASP A CB  1 
ATOM   2269 C CG  . ASP A 1 295 ? -15.21217 -23.91552 27.77491  1.000 28.78853 ? 295 ASP A CG  1 
ATOM   2270 O OD1 . ASP A 1 295 ? -15.74360 -25.04395 27.84093  1.000 32.66602 ? 295 ASP A OD1 1 
ATOM   2271 O OD2 . ASP A 1 295 ? -15.11799 -23.25370 26.71691  1.000 27.11435 ? 295 ASP A OD2 1 
ATOM   2272 N N   . VAL A 1 296 ? -14.56349 -22.26530 31.91648  1.000 28.19317 ? 296 VAL A N   1 
ATOM   2273 C CA  . VAL A 1 296 ? -13.82128 -21.59298 32.97857  1.000 29.65450 ? 296 VAL A CA  1 
ATOM   2274 C C   . VAL A 1 296 ? -13.84090 -22.43262 34.25062  1.000 30.24148 ? 296 VAL A C   1 
ATOM   2275 O O   . VAL A 1 296 ? -12.81008 -22.60427 34.91667  1.000 32.53981 ? 296 VAL A O   1 
ATOM   2276 C CB  . VAL A 1 296 ? -14.39142 -20.18100 33.21540  1.000 24.64180 ? 296 VAL A CB  1 
ATOM   2277 C CG1 . VAL A 1 296 ? -13.67271 -19.52749 34.36480  1.000 24.93020 ? 296 VAL A CG1 1 
ATOM   2278 C CG2 . VAL A 1 296 ? -14.24318 -19.32497 31.96026  1.000 22.43126 ? 296 VAL A CG2 1 
ATOM   2279 N N   . VAL A 1 297 ? -15.00949 -22.97599 34.60314  1.000 31.71568 ? 297 VAL A N   1 
ATOM   2280 C CA  . VAL A 1 297 ? -15.10508 -23.82906 35.78791  1.000 32.99496 ? 297 VAL A CA  1 
ATOM   2281 C C   . VAL A 1 297 ? -14.22207 -25.05716 35.63150  1.000 42.26119 ? 297 VAL A C   1 
ATOM   2282 O O   . VAL A 1 297 ? -13.48173 -25.43218 36.55324  1.000 35.25325 ? 297 VAL A O   1 
ATOM   2283 C CB  . VAL A 1 297 ? -16.56467 -24.23860 36.04538  1.000 32.16490 ? 297 VAL A CB  1 
ATOM   2284 C CG1 . VAL A 1 297 ? -16.63537 -25.18631 37.23633  1.000 35.75101 ? 297 VAL A CG1 1 
ATOM   2285 C CG2 . VAL A 1 297 ? -17.44402 -23.02819 36.27218  1.000 34.94266 ? 297 VAL A CG2 1 
ATOM   2286 N N   . ARG A 1 298 ? -14.30238 -25.71334 34.46857  1.000 33.32778 ? 298 ARG A N   1 
ATOM   2287 C CA  . ARG A 1 298 ? -13.50311 -26.91008 34.23478  1.000 36.92508 ? 298 ARG A CA  1 
ATOM   2288 C C   . ARG A 1 298 ? -12.02471 -26.62211 34.44534  1.000 35.94038 ? 298 ARG A C   1 
ATOM   2289 O O   . ARG A 1 298 ? -11.34046 -27.32724 35.19780  1.000 43.61257 ? 298 ARG A O   1 
ATOM   2290 C CB  . ARG A 1 298 ? -13.75644 -27.45140 32.82167  1.000 34.63688 ? 298 ARG A CB  1 
ATOM   2291 C CG  . ARG A 1 298 ? -12.63068 -28.35628 32.31483  1.000 45.32351 ? 298 ARG A CG  1 
ATOM   2292 C CD  . ARG A 1 298 ? -13.01060 -29.15516 31.07347  1.000 50.99363 ? 298 ARG A CD  1 
ATOM   2293 N NE  . ARG A 1 298 ? -12.77801 -28.43993 29.82171  1.000 52.28717 ? 298 ARG A NE  1 
ATOM   2294 C CZ  . ARG A 1 298 ? -13.71908 -27.78321 29.15412  1.000 48.02907 ? 298 ARG A CZ  1 
ATOM   2295 N NH1 . ARG A 1 298 ? -14.96065 -27.70381 29.61171  1.000 42.10531 ? 298 ARG A NH1 1 
ATOM   2296 N NH2 . ARG A 1 298 ? -13.40854 -27.19649 27.99872  1.000 42.50218 ? 298 ARG A NH2 1 
ATOM   2297 N N   . GLN A 1 299 ? -11.51825 -25.56636 33.81076  1.000 37.86617 ? 299 GLN A N   1 
ATOM   2298 C CA  . GLN A 1 299 ? -10.08669 -25.30460 33.86993  1.000 39.35245 ? 299 GLN A CA  1 
ATOM   2299 C C   . GLN A 1 299 ? -9.66672  -24.75409 35.21644  1.000 42.10201 ? 299 GLN A C   1 
ATOM   2300 O O   . GLN A 1 299 ? -8.54510  -25.01663 35.66453  1.000 44.12864 ? 299 GLN A O   1 
ATOM   2301 C CB  . GLN A 1 299 ? -9.66283  -24.33487 32.76747  1.000 37.59945 ? 299 GLN A CB  1 
ATOM   2302 C CG  . GLN A 1 299 ? -8.14986  -24.21004 32.64429  1.000 37.11969 ? 299 GLN A CG  1 
ATOM   2303 C CD  . GLN A 1 299 ? -7.71152  -23.39503 31.45197  1.000 34.03543 ? 299 GLN A CD  1 
ATOM   2304 O OE1 . GLN A 1 299 ? -6.62093  -22.82581 31.44677  1.000 30.95141 ? 299 GLN A OE1 1 
ATOM   2305 N NE2 . GLN A 1 299 ? -8.56219  -23.32720 30.43455  1.000 32.40016 ? 299 GLN A NE2 1 
ATOM   2306 N N   . CYS A 1 300 ? -10.53196 -23.99138 35.87894  1.000 39.44422 ? 300 CYS A N   1 
ATOM   2307 C CA  . CYS A 1 300 ? -10.12737 -23.43861 37.16162  1.000 37.87382 ? 300 CYS A CA  1 
ATOM   2308 C C   . CYS A 1 300 ? -10.21668 -24.45514 38.29806  1.000 40.48511 ? 300 CYS A C   1 
ATOM   2309 O O   . CYS A 1 300 ? -9.63027  -24.21719 39.35730  1.000 45.51359 ? 300 CYS A O   1 
ATOM   2310 C CB  . CYS A 1 300 ? -10.94082 -22.16615 37.46151  1.000 29.66152 ? 300 CYS A CB  1 
ATOM   2311 S SG  . CYS A 1 300 ? -10.35188 -20.72256 36.47141  1.000 45.09391 ? 300 CYS A SG  1 
ATOM   2312 N N   . SER A 1 301 ? -10.88417 -25.59923 38.09757  1.000 43.56777 ? 301 SER A N   1 
ATOM   2313 C CA  . SER A 1 301 ? -10.92182 -26.65312 39.10361  1.000 42.45550 ? 301 SER A CA  1 
ATOM   2314 C C   . SER A 1 301 ? -10.16749 -27.91401 38.70108  1.000 49.63252 ? 301 SER A C   1 
ATOM   2315 O O   . SER A 1 301 ? -10.01939 -28.81571 39.53541  1.000 57.65796 ? 301 SER A O   1 
ATOM   2316 C CB  . SER A 1 301 ? -12.37340 -27.02057 39.45013  1.000 48.33194 ? 301 SER A CB  1 
ATOM   2317 O OG  . SER A 1 301 ? -13.04624 -27.59581 38.34669  1.000 49.26562 ? 301 SER A OG  1 
ATOM   2318 N N   . GLY A 1 302 ? -9.68243  -28.00237 37.46133  1.000 51.81663 ? 302 GLY A N   1 
ATOM   2319 C CA  . GLY A 1 302 ? -8.86330  -29.12254 37.03162  1.000 41.41173 ? 302 GLY A CA  1 
ATOM   2320 C C   . GLY A 1 302 ? -9.64687  -30.39139 36.76708  1.000 50.35387 ? 302 GLY A C   1 
ATOM   2321 O O   . GLY A 1 302 ? -9.26704  -31.46934 37.23507  1.000 50.64955 ? 302 GLY A O   1 
ATOM   2322 N N   . VAL A 1 303 ? -10.73910 -30.28228 36.01819  1.000 38.62346 ? 303 VAL A N   1 
ATOM   2323 C CA  . VAL A 1 303 ? -11.58890 -31.44165 35.75722  1.000 47.85536 ? 303 VAL A CA  1 
ATOM   2324 C C   . VAL A 1 303 ? -10.86967 -32.44564 34.86329  1.000 51.57677 ? 303 VAL A C   1 
ATOM   2325 O O   . VAL A 1 303 ? -10.41985 -32.08668 33.77817  1.000 40.45876 ? 303 VAL A O   1 
ATOM   2326 C CB  . VAL A 1 303 ? -12.92388 -31.02230 35.12366  1.000 40.30906 ? 303 VAL A CB  1 
ATOM   2327 C CG1 . VAL A 1 303 ? -13.73397 -32.25056 34.74403  1.000 43.09539 ? 303 VAL A CG1 1 
ATOM   2328 C CG2 . VAL A 1 303 ? -13.70530 -30.12815 36.07830  1.000 40.30087 ? 303 VAL A CG2 1 
HETATM 2329 O O   . HOH B 2 .   ? -14.52411 -17.89002 18.05569  1.000 38.78867 ? 401 HOH A O   1 
HETATM 2330 O O   . HOH B 2 .   ? -18.05156 -3.01118  41.12829  1.000 41.83846 ? 402 HOH A O   1 
HETATM 2331 O O   . HOH B 2 .   ? -12.04995 -49.65480 1.31908   1.000 29.48582 ? 403 HOH A O   1 
HETATM 2332 O O   . HOH B 2 .   ? -19.789   6.631     21.920    1.000 40.10045 ? 404 HOH A O   1 
HETATM 2333 O O   . HOH B 2 .   ? -26.65897 -46.67818 -9.17186  1.000 38.25833 ? 405 HOH A O   1 
HETATM 2334 O O   . HOH B 2 .   ? -11.03107 -27.94075 26.28444  1.000 38.11390 ? 406 HOH A O   1 
HETATM 2335 O O   . HOH B 2 .   ? -18.84262 -51.05882 18.06782  1.000 40.14361 ? 407 HOH A O   1 
HETATM 2336 O O   . HOH B 2 .   ? -5.14302  -27.40211 9.58734   1.000 31.69490 ? 408 HOH A O   1 
HETATM 2337 O O   . HOH B 2 .   ? -22.74182 1.34892   35.14653  1.000 37.78788 ? 409 HOH A O   1 
HETATM 2338 O O   . HOH B 2 .   ? -25.99763 -39.43099 11.35979  1.000 43.05531 ? 410 HOH A O   1 
HETATM 2339 O O   . HOH B 2 .   ? -17.19429 -52.79163 -1.28642  1.000 33.52177 ? 411 HOH A O   1 
HETATM 2340 O O   . HOH B 2 .   ? -28.27556 -3.42749  39.36492  1.000 25.70164 ? 412 HOH A O   1 
HETATM 2341 O O   . HOH B 2 .   ? -14.13956 -44.48432 -6.80816  1.000 35.27566 ? 413 HOH A O   1 
HETATM 2342 O O   . HOH B 2 .   ? -18.54213 -25.47678 27.30826  1.000 31.16557 ? 414 HOH A O   1 
HETATM 2343 O O   . HOH B 2 .   ? -31.17141 -6.02678  35.64471  1.000 38.85013 ? 415 HOH A O   1 
HETATM 2344 O O   . HOH B 2 .   ? -11.08084 -34.69926 13.15409  1.000 28.78601 ? 416 HOH A O   1 
HETATM 2345 O O   . HOH B 2 .   ? -15.47997 -26.94191 24.94945  1.000 33.13345 ? 417 HOH A O   1 
HETATM 2346 O O   . HOH B 2 .   ? -10.56531 -44.05103 20.01455  1.000 34.79936 ? 418 HOH A O   1 
HETATM 2347 O O   . HOH B 2 .   ? -15.83611 -51.50234 18.96226  1.000 40.70205 ? 419 HOH A O   1 
HETATM 2348 O O   . HOH B 2 .   ? -21.17284 -39.47741 -9.96885  1.000 32.38341 ? 420 HOH A O   1 
HETATM 2349 O O   . HOH B 2 .   ? -19.89633 -52.28102 -5.12092  1.000 29.72408 ? 421 HOH A O   1 
HETATM 2350 O O   . HOH B 2 .   ? -19.38185 -21.23352 -0.87532  1.000 40.85951 ? 422 HOH A O   1 
HETATM 2351 O O   . HOH B 2 .   ? -29.40377 -26.94185 8.87916   1.000 32.92854 ? 423 HOH A O   1 
HETATM 2352 O O   . HOH B 2 .   ? -21.94025 -31.75290 -11.33749 1.000 41.11925 ? 424 HOH A O   1 
HETATM 2353 O O   . HOH B 2 .   ? -28.10567 -24.46324 5.91796   1.000 33.29634 ? 425 HOH A O   1 
HETATM 2354 O O   . HOH B 2 .   ? -12.86385 -22.86396 25.42953  1.000 28.63729 ? 426 HOH A O   1 
HETATM 2355 O O   . HOH B 2 .   ? -14.45451 -16.06391 26.73782  1.000 24.47416 ? 427 HOH A O   1 
HETATM 2356 O O   . HOH B 2 .   ? -25.52305 -44.88981 -4.86268  1.000 28.92956 ? 428 HOH A O   1 
HETATM 2357 O O   . HOH B 2 .   ? -24.90023 4.02125   29.83966  1.000 50.22512 ? 429 HOH A O   1 
HETATM 2358 O O   . HOH B 2 .   ? -22.03794 -45.23233 14.16045  1.000 33.12280 ? 430 HOH A O   1 
HETATM 2359 O O   . HOH B 2 .   ? -7.65333  -35.31529 3.08955   1.000 28.82163 ? 431 HOH A O   1 
HETATM 2360 O O   . HOH B 2 .   ? -13.68022 -20.92836 -0.64430  1.000 37.18096 ? 432 HOH A O   1 
HETATM 2361 O O   . HOH B 2 .   ? -14.71712 -19.99333 16.09861  1.000 25.78150 ? 433 HOH A O   1 
HETATM 2362 O O   . HOH B 2 .   ? -28.82134 -13.50344 23.55664  1.000 40.33470 ? 434 HOH A O   1 
HETATM 2363 O O   . HOH B 2 .   ? -23.89009 -34.06285 15.81137  1.000 29.95043 ? 435 HOH A O   1 
HETATM 2364 O O   . HOH B 2 .   ? -20.87243 -32.00306 1.76226   1.000 22.50138 ? 436 HOH A O   1 
HETATM 2365 O O   . HOH B 2 .   ? -21.00142 -54.40819 9.62020   1.000 43.22218 ? 437 HOH A O   1 
HETATM 2366 O O   . HOH B 2 .   ? -16.43837 -4.13869  39.02768  1.000 43.31472 ? 438 HOH A O   1 
HETATM 2367 O O   . HOH B 2 .   ? -20.08225 -7.76210  43.73979  1.000 34.76707 ? 439 HOH A O   1 
HETATM 2368 O O   . HOH B 2 .   ? -20.18458 -31.22904 21.77088  1.000 33.47555 ? 440 HOH A O   1 
HETATM 2369 O O   . HOH B 2 .   ? -18.46106 -7.21807  18.69801  1.000 35.89758 ? 441 HOH A O   1 
HETATM 2370 O O   . HOH B 2 .   ? -29.51684 -35.24789 1.28520   1.000 32.36343 ? 442 HOH A O   1 
HETATM 2371 O O   . HOH B 2 .   ? -2.67451  -41.77864 18.54278  1.000 44.20613 ? 443 HOH A O   1 
HETATM 2372 O O   . HOH B 2 .   ? -32.35321 -0.06434  33.78578  1.000 37.11047 ? 444 HOH A O   1 
HETATM 2373 O O   . HOH B 2 .   ? -1.74902  2.14865   29.94916  1.000 44.55031 ? 445 HOH A O   1 
HETATM 2374 O O   . HOH B 2 .   ? -26.55349 -28.14366 1.44291   1.000 29.12843 ? 446 HOH A O   1 
HETATM 2375 O O   . HOH B 2 .   ? -11.27104 -24.51641 29.84442  1.000 36.71075 ? 447 HOH A O   1 
HETATM 2376 O O   . HOH B 2 .   ? -21.77245 -20.02260 26.10752  1.000 32.43363 ? 448 HOH A O   1 
HETATM 2377 O O   . HOH B 2 .   ? -11.75104 -26.22585 4.00771   1.000 34.42940 ? 449 HOH A O   1 
HETATM 2378 O O   . HOH B 2 .   ? -31.79358 -2.66348  26.73339  1.000 35.17236 ? 450 HOH A O   1 
HETATM 2379 O O   . HOH B 2 .   ? -28.06551 -33.90704 -12.73696 1.000 42.28894 ? 451 HOH A O   1 
HETATM 2380 O O   . HOH B 2 .   ? -27.97137 -28.78690 5.97324   1.000 29.66498 ? 452 HOH A O   1 
HETATM 2381 O O   . HOH B 2 .   ? -25.95179 -9.60224  39.55860  1.000 37.66596 ? 453 HOH A O   1 
HETATM 2382 O O   . HOH B 2 .   ? -15.88099 -43.18775 -8.68446  1.000 38.92118 ? 454 HOH A O   1 
HETATM 2383 O O   . HOH B 2 .   ? -27.72603 -26.89757 3.93249   1.000 29.43607 ? 455 HOH A O   1 
HETATM 2384 O O   . HOH B 2 .   ? -6.96450  -14.90350 27.75158  1.000 30.78740 ? 456 HOH A O   1 
HETATM 2385 O O   . HOH B 2 .   ? -20.38223 0.91117   33.95397  1.000 35.72627 ? 457 HOH A O   1 
HETATM 2386 O O   . HOH B 2 .   ? -21.61071 -23.93796 9.45754   1.000 26.28691 ? 458 HOH A O   1 
HETATM 2387 O O   . HOH B 2 .   ? -30.52113 -17.09809 26.82162  1.000 34.45467 ? 459 HOH A O   1 
HETATM 2388 O O   . HOH B 2 .   ? -9.05712  -48.70819 14.90557  1.000 34.87966 ? 460 HOH A O   1 
HETATM 2389 O O   . HOH B 2 .   ? -8.99731  -44.87992 1.58374   1.000 38.97887 ? 461 HOH A O   1 
HETATM 2390 O O   . HOH B 2 .   ? -7.54689  -22.32001 19.64893  1.000 36.48060 ? 462 HOH A O   1 
HETATM 2391 O O   . HOH B 2 .   ? -14.81018 -6.40792  22.33437  1.000 30.56578 ? 463 HOH A O   1 
HETATM 2392 O O   . HOH B 2 .   ? -24.26238 -13.93989 25.64514  1.000 28.83905 ? 464 HOH A O   1 
HETATM 2393 O O   . HOH B 2 .   ? -1.020    -38.417   19.280    1.000 28.37661 ? 465 HOH A O   1 
HETATM 2394 O O   . HOH B 2 .   ? -32.85095 -4.45782  33.75890  1.000 32.71394 ? 466 HOH A O   1 
HETATM 2395 O O   . HOH B 2 .   ? -23.40417 -50.51174 -4.11307  1.000 35.15916 ? 467 HOH A O   1 
HETATM 2396 O O   . HOH B 2 .   ? -27.00884 -29.72553 -10.78797 1.000 43.18783 ? 468 HOH A O   1 
HETATM 2397 O O   . HOH B 2 .   ? -28.93125 -42.72011 0.12142   1.000 36.42468 ? 469 HOH A O   1 
HETATM 2398 O O   . HOH B 2 .   ? -28.39662 -32.33032 20.14228  1.000 33.06846 ? 470 HOH A O   1 
HETATM 2399 O O   . HOH B 2 .   ? -16.14572 -38.39676 -8.45215  1.000 38.27820 ? 471 HOH A O   1 
HETATM 2400 O O   . HOH B 2 .   ? 0.139     -29.153   15.197    1.000 39.31055 ? 472 HOH A O   1 
HETATM 2401 O O   . HOH B 2 .   ? -28.68457 -23.33280 12.42694  1.000 35.62739 ? 473 HOH A O   1 
HETATM 2402 O O   . HOH B 2 .   ? -17.67019 -14.89973 11.10538  1.000 42.24409 ? 474 HOH A O   1 
HETATM 2403 O O   . HOH B 2 .   ? -10.48016 -23.80800 26.76361  1.000 34.63207 ? 475 HOH A O   1 
HETATM 2404 O O   . HOH B 2 .   ? -24.38832 -32.69444 -10.40947 1.000 34.54345 ? 476 HOH A O   1 
HETATM 2405 O O   . HOH B 2 .   ? -28.51178 -31.86274 -4.46699  1.000 32.53936 ? 477 HOH A O   1 
HETATM 2406 O O   . HOH B 2 .   ? -12.34516 -14.08745 20.79853  1.000 44.21501 ? 478 HOH A O   1 
HETATM 2407 O O   . HOH B 2 .   ? -26.33547 -39.68731 19.74241  1.000 33.97107 ? 479 HOH A O   1 
HETATM 2408 O O   . HOH B 2 .   ? -26.76686 -15.98827 39.22137  1.000 34.83486 ? 480 HOH A O   1 
HETATM 2409 O O   . HOH B 2 .   ? -12.38209 -6.57662  22.28096  1.000 29.66572 ? 481 HOH A O   1 
HETATM 2410 O O   . HOH B 2 .   ? -26.11984 -20.02508 1.63186   1.000 40.82132 ? 482 HOH A O   1 
HETATM 2411 O O   . HOH B 2 .   ? -13.96449 2.03661   23.01392  1.000 43.10650 ? 483 HOH A O   1 
HETATM 2412 O O   . HOH B 2 .   ? -14.67676 -25.35265 0.59217   1.000 36.67778 ? 484 HOH A O   1 
HETATM 2413 O O   . HOH B 2 .   ? -25.17595 -46.74018 5.51203   1.000 37.57900 ? 485 HOH A O   1 
HETATM 2414 O O   . HOH B 2 .   ? -16.98899 -4.57060  19.33118  1.000 37.71925 ? 486 HOH A O   1 
HETATM 2415 O O   . HOH B 2 .   ? -19.68873 -25.88590 24.90341  1.000 34.04838 ? 487 HOH A O   1 
HETATM 2416 O O   . HOH B 2 .   ? -2.20451  -28.04039 10.07092  1.000 41.81656 ? 488 HOH A O   1 
HETATM 2417 O O   . HOH B 2 .   ? -27.11224 -44.41050 -1.79683  1.000 38.10175 ? 489 HOH A O   1 
HETATM 2418 O O   . HOH B 2 .   ? -7.34041  -46.63183 0.01525   1.000 37.11826 ? 490 HOH A O   1 
HETATM 2419 O O   . HOH B 2 .   ? -6.40853  -24.64500 21.80356  1.000 34.67552 ? 491 HOH A O   1 
HETATM 2420 O O   . HOH B 2 .   ? -21.80804 -45.03580 23.01517  1.000 44.90396 ? 492 HOH A O   1 
HETATM 2421 O O   . HOH B 2 .   ? -29.18262 -24.41269 14.90781  1.000 42.44230 ? 493 HOH A O   1 
HETATM 2422 O O   . HOH B 2 .   ? -4.90424  -26.37758 21.82221  0.50  37.37797 ? 494 HOH A O   1 
HETATM 2423 O O   . HOH B 2 .   ? -21.451   -52.023   15.290    1.000 44.86132 ? 495 HOH A O   1 
HETATM 2424 O O   . HOH B 2 .   ? -0.94128  -39.25977 5.65014   1.000 44.24753 ? 496 HOH A O   1 
HETATM 2425 O O   . HOH B 2 .   ? -26.69621 -34.31427 16.08675  1.000 37.81582 ? 497 HOH A O   1 
HETATM 2426 O O   . HOH B 2 .   ? -29.720   -46.745   0.467     1.000 47.09780 ? 498 HOH A O   1 
HETATM 2427 O O   . HOH B 2 .   ? -12.90745 -23.35187 -0.91840  1.000 40.13858 ? 499 HOH A O   1 
HETATM 2428 O O   . HOH B 2 .   ? -26.866   -52.501   1.515     1.000 37.30353 ? 500 HOH A O   1 
HETATM 2429 O O   . HOH B 2 .   ? -24.78322 -15.88954 23.78808  1.000 42.72525 ? 501 HOH A O   1 
HETATM 2430 O O   . HOH B 2 .   ? -25.52474 -42.83979 17.14363  1.000 43.37126 ? 502 HOH A O   1 
HETATM 2431 O O   . HOH B 2 .   ? -9.926    -25.056   -4.564    1.000 36.87910 ? 503 HOH A O   1 
HETATM 2432 O O   . HOH B 2 .   ? -28.14440 -43.47720 -4.11113  1.000 37.16956 ? 504 HOH A O   1 
HETATM 2433 O O   . HOH B 2 .   ? -22.52994 -52.78706 -5.19345  1.000 40.66410 ? 505 HOH A O   1 
HETATM 2434 O O   . HOH B 2 .   ? -24.48141 -50.16909 -11.30907 1.000 47.12288 ? 506 HOH A O   1 
HETATM 2435 O O   . HOH B 2 .   ? -16.475   -60.519   -2.156    1.000 33.72881 ? 507 HOH A O   1 
HETATM 2436 O O   . HOH B 2 .   ? -15.63247 -3.84979  21.23446  1.000 32.89658 ? 508 HOH A O   1 
HETATM 2437 O O   . HOH B 2 .   ? -28.86563 -9.97824  38.75567  1.000 34.00130 ? 509 HOH A O   1 
# 
