data_9BHU
# 
_entry.id   9BHU 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BHU         pdb_00009bhu 10.2210/pdb9bhu/pdb 
WWPDB D_1000283381 ?            ?                   
EMDB  EMD-44553    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-27 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BHU 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-22 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Streptomyces griseus Family 2B encapsulin shell' 
_pdbx_database_related.db_id          EMD-44553 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              tgiessen@umich.edu 
_pdbx_contact_author.name_first         Giessen 
_pdbx_contact_author.name_last          Tobias 
_pdbx_contact_author.name_mi            W. 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-8871-3053 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Andreas, M.P.' 1 0000-0001-8871-3053 
'Giessen, T.W.' 2 0000-0001-6328-2031 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            15 
_citation.language                  ? 
_citation.page_first                9715 
_citation.page_last                 9715 
_citation.title                     
'The biosynthesis of the odorant 2-methylisoborneol is compartmentalized inside a protein shell.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-024-54175-4 
_citation.pdbx_database_id_PubMed   39521781 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Andreas, M.P.' 1 ?                   
primary 'Giessen, T.W.' 2 0000-0001-6328-2031 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Nucleotide-binding protein' 52014.137 1 ? ? ? 'Residues 1-39, 147-152, and 216-245 are unresolved in the map.' 
2 non-polymer syn 'CALCIUM ION'                40.078    1 ? ? ? ?                                                                
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Sporulation protein' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MTVDSTSEARLEVPRQSSLGTAAARNLASTTKSAPQMQEITSRWLLRMLPWVETKGGAYRVNRRLTFTVGDGRVEFVQDG
STVRVIPQELGELALLRDFDDAEVLSAIADRCVQRDFRAGETLVERGTAADELHLIAHGRIGQASAGSYGDEVTLDVLAD
GDRFGEHALLDEDARWSQTATAETSGTLLTLSRADFAAVVANSPALRSHLAAFTARSEQRQNHRGEAEIAMSAGHVGEHE
LPGAFADYELKPREYELSVAQTILRVHTRVADLYNGPMNQTEEQLRLTIEALRERQEHELINNREFGLLHNADFKQRIQT
HSGPPTPDDLDELLCRRRGTKFFLAHPRTIAAMGREFNARGLYPDHTDLGGQQVPAWRGVPILPCGKIPITPERTSSILA
LRTGEEDQGVIGLRQTGLPDEYEPGLSVRFMNIDEKAIISYLVSTYYSAAILVPDAVGVLENVQIANWPR
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MTVDSTSEARLEVPRQSSLGTAAARNLASTTKSAPQMQEITSRWLLRMLPWVETKGGAYRVNRRLTFTVGDGRVEFVQDG
STVRVIPQELGELALLRDFDDAEVLSAIADRCVQRDFRAGETLVERGTAADELHLIAHGRIGQASAGSYGDEVTLDVLAD
GDRFGEHALLDEDARWSQTATAETSGTLLTLSRADFAAVVANSPALRSHLAAFTARSEQRQNHRGEAEIAMSAGHVGEHE
LPGAFADYELKPREYELSVAQTILRVHTRVADLYNGPMNQTEEQLRLTIEALRERQEHELINNREFGLLHNADFKQRIQT
HSGPPTPDDLDELLCRRRGTKFFLAHPRTIAAMGREFNARGLYPDHTDLGGQQVPAWRGVPILPCGKIPITPERTSSILA
LRTGEEDQGVIGLRQTGLPDEYEPGLSVRFMNIDEKAIISYLVSTYYSAAILVPDAVGVLENVQIANWPR
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        'CALCIUM ION' 
_pdbx_entity_nonpoly.comp_id     CA 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   THR n 
1 3   VAL n 
1 4   ASP n 
1 5   SER n 
1 6   THR n 
1 7   SER n 
1 8   GLU n 
1 9   ALA n 
1 10  ARG n 
1 11  LEU n 
1 12  GLU n 
1 13  VAL n 
1 14  PRO n 
1 15  ARG n 
1 16  GLN n 
1 17  SER n 
1 18  SER n 
1 19  LEU n 
1 20  GLY n 
1 21  THR n 
1 22  ALA n 
1 23  ALA n 
1 24  ALA n 
1 25  ARG n 
1 26  ASN n 
1 27  LEU n 
1 28  ALA n 
1 29  SER n 
1 30  THR n 
1 31  THR n 
1 32  LYS n 
1 33  SER n 
1 34  ALA n 
1 35  PRO n 
1 36  GLN n 
1 37  MET n 
1 38  GLN n 
1 39  GLU n 
1 40  ILE n 
1 41  THR n 
1 42  SER n 
1 43  ARG n 
1 44  TRP n 
1 45  LEU n 
1 46  LEU n 
1 47  ARG n 
1 48  MET n 
1 49  LEU n 
1 50  PRO n 
1 51  TRP n 
1 52  VAL n 
1 53  GLU n 
1 54  THR n 
1 55  LYS n 
1 56  GLY n 
1 57  GLY n 
1 58  ALA n 
1 59  TYR n 
1 60  ARG n 
1 61  VAL n 
1 62  ASN n 
1 63  ARG n 
1 64  ARG n 
1 65  LEU n 
1 66  THR n 
1 67  PHE n 
1 68  THR n 
1 69  VAL n 
1 70  GLY n 
1 71  ASP n 
1 72  GLY n 
1 73  ARG n 
1 74  VAL n 
1 75  GLU n 
1 76  PHE n 
1 77  VAL n 
1 78  GLN n 
1 79  ASP n 
1 80  GLY n 
1 81  SER n 
1 82  THR n 
1 83  VAL n 
1 84  ARG n 
1 85  VAL n 
1 86  ILE n 
1 87  PRO n 
1 88  GLN n 
1 89  GLU n 
1 90  LEU n 
1 91  GLY n 
1 92  GLU n 
1 93  LEU n 
1 94  ALA n 
1 95  LEU n 
1 96  LEU n 
1 97  ARG n 
1 98  ASP n 
1 99  PHE n 
1 100 ASP n 
1 101 ASP n 
1 102 ALA n 
1 103 GLU n 
1 104 VAL n 
1 105 LEU n 
1 106 SER n 
1 107 ALA n 
1 108 ILE n 
1 109 ALA n 
1 110 ASP n 
1 111 ARG n 
1 112 CYS n 
1 113 VAL n 
1 114 GLN n 
1 115 ARG n 
1 116 ASP n 
1 117 PHE n 
1 118 ARG n 
1 119 ALA n 
1 120 GLY n 
1 121 GLU n 
1 122 THR n 
1 123 LEU n 
1 124 VAL n 
1 125 GLU n 
1 126 ARG n 
1 127 GLY n 
1 128 THR n 
1 129 ALA n 
1 130 ALA n 
1 131 ASP n 
1 132 GLU n 
1 133 LEU n 
1 134 HIS n 
1 135 LEU n 
1 136 ILE n 
1 137 ALA n 
1 138 HIS n 
1 139 GLY n 
1 140 ARG n 
1 141 ILE n 
1 142 GLY n 
1 143 GLN n 
1 144 ALA n 
1 145 SER n 
1 146 ALA n 
1 147 GLY n 
1 148 SER n 
1 149 TYR n 
1 150 GLY n 
1 151 ASP n 
1 152 GLU n 
1 153 VAL n 
1 154 THR n 
1 155 LEU n 
1 156 ASP n 
1 157 VAL n 
1 158 LEU n 
1 159 ALA n 
1 160 ASP n 
1 161 GLY n 
1 162 ASP n 
1 163 ARG n 
1 164 PHE n 
1 165 GLY n 
1 166 GLU n 
1 167 HIS n 
1 168 ALA n 
1 169 LEU n 
1 170 LEU n 
1 171 ASP n 
1 172 GLU n 
1 173 ASP n 
1 174 ALA n 
1 175 ARG n 
1 176 TRP n 
1 177 SER n 
1 178 GLN n 
1 179 THR n 
1 180 ALA n 
1 181 THR n 
1 182 ALA n 
1 183 GLU n 
1 184 THR n 
1 185 SER n 
1 186 GLY n 
1 187 THR n 
1 188 LEU n 
1 189 LEU n 
1 190 THR n 
1 191 LEU n 
1 192 SER n 
1 193 ARG n 
1 194 ALA n 
1 195 ASP n 
1 196 PHE n 
1 197 ALA n 
1 198 ALA n 
1 199 VAL n 
1 200 VAL n 
1 201 ALA n 
1 202 ASN n 
1 203 SER n 
1 204 PRO n 
1 205 ALA n 
1 206 LEU n 
1 207 ARG n 
1 208 SER n 
1 209 HIS n 
1 210 LEU n 
1 211 ALA n 
1 212 ALA n 
1 213 PHE n 
1 214 THR n 
1 215 ALA n 
1 216 ARG n 
1 217 SER n 
1 218 GLU n 
1 219 GLN n 
1 220 ARG n 
1 221 GLN n 
1 222 ASN n 
1 223 HIS n 
1 224 ARG n 
1 225 GLY n 
1 226 GLU n 
1 227 ALA n 
1 228 GLU n 
1 229 ILE n 
1 230 ALA n 
1 231 MET n 
1 232 SER n 
1 233 ALA n 
1 234 GLY n 
1 235 HIS n 
1 236 VAL n 
1 237 GLY n 
1 238 GLU n 
1 239 HIS n 
1 240 GLU n 
1 241 LEU n 
1 242 PRO n 
1 243 GLY n 
1 244 ALA n 
1 245 PHE n 
1 246 ALA n 
1 247 ASP n 
1 248 TYR n 
1 249 GLU n 
1 250 LEU n 
1 251 LYS n 
1 252 PRO n 
1 253 ARG n 
1 254 GLU n 
1 255 TYR n 
1 256 GLU n 
1 257 LEU n 
1 258 SER n 
1 259 VAL n 
1 260 ALA n 
1 261 GLN n 
1 262 THR n 
1 263 ILE n 
1 264 LEU n 
1 265 ARG n 
1 266 VAL n 
1 267 HIS n 
1 268 THR n 
1 269 ARG n 
1 270 VAL n 
1 271 ALA n 
1 272 ASP n 
1 273 LEU n 
1 274 TYR n 
1 275 ASN n 
1 276 GLY n 
1 277 PRO n 
1 278 MET n 
1 279 ASN n 
1 280 GLN n 
1 281 THR n 
1 282 GLU n 
1 283 GLU n 
1 284 GLN n 
1 285 LEU n 
1 286 ARG n 
1 287 LEU n 
1 288 THR n 
1 289 ILE n 
1 290 GLU n 
1 291 ALA n 
1 292 LEU n 
1 293 ARG n 
1 294 GLU n 
1 295 ARG n 
1 296 GLN n 
1 297 GLU n 
1 298 HIS n 
1 299 GLU n 
1 300 LEU n 
1 301 ILE n 
1 302 ASN n 
1 303 ASN n 
1 304 ARG n 
1 305 GLU n 
1 306 PHE n 
1 307 GLY n 
1 308 LEU n 
1 309 LEU n 
1 310 HIS n 
1 311 ASN n 
1 312 ALA n 
1 313 ASP n 
1 314 PHE n 
1 315 LYS n 
1 316 GLN n 
1 317 ARG n 
1 318 ILE n 
1 319 GLN n 
1 320 THR n 
1 321 HIS n 
1 322 SER n 
1 323 GLY n 
1 324 PRO n 
1 325 PRO n 
1 326 THR n 
1 327 PRO n 
1 328 ASP n 
1 329 ASP n 
1 330 LEU n 
1 331 ASP n 
1 332 GLU n 
1 333 LEU n 
1 334 LEU n 
1 335 CYS n 
1 336 ARG n 
1 337 ARG n 
1 338 ARG n 
1 339 GLY n 
1 340 THR n 
1 341 LYS n 
1 342 PHE n 
1 343 PHE n 
1 344 LEU n 
1 345 ALA n 
1 346 HIS n 
1 347 PRO n 
1 348 ARG n 
1 349 THR n 
1 350 ILE n 
1 351 ALA n 
1 352 ALA n 
1 353 MET n 
1 354 GLY n 
1 355 ARG n 
1 356 GLU n 
1 357 PHE n 
1 358 ASN n 
1 359 ALA n 
1 360 ARG n 
1 361 GLY n 
1 362 LEU n 
1 363 TYR n 
1 364 PRO n 
1 365 ASP n 
1 366 HIS n 
1 367 THR n 
1 368 ASP n 
1 369 LEU n 
1 370 GLY n 
1 371 GLY n 
1 372 GLN n 
1 373 GLN n 
1 374 VAL n 
1 375 PRO n 
1 376 ALA n 
1 377 TRP n 
1 378 ARG n 
1 379 GLY n 
1 380 VAL n 
1 381 PRO n 
1 382 ILE n 
1 383 LEU n 
1 384 PRO n 
1 385 CYS n 
1 386 GLY n 
1 387 LYS n 
1 388 ILE n 
1 389 PRO n 
1 390 ILE n 
1 391 THR n 
1 392 PRO n 
1 393 GLU n 
1 394 ARG n 
1 395 THR n 
1 396 SER n 
1 397 SER n 
1 398 ILE n 
1 399 LEU n 
1 400 ALA n 
1 401 LEU n 
1 402 ARG n 
1 403 THR n 
1 404 GLY n 
1 405 GLU n 
1 406 GLU n 
1 407 ASP n 
1 408 GLN n 
1 409 GLY n 
1 410 VAL n 
1 411 ILE n 
1 412 GLY n 
1 413 LEU n 
1 414 ARG n 
1 415 GLN n 
1 416 THR n 
1 417 GLY n 
1 418 LEU n 
1 419 PRO n 
1 420 ASP n 
1 421 GLU n 
1 422 TYR n 
1 423 GLU n 
1 424 PRO n 
1 425 GLY n 
1 426 LEU n 
1 427 SER n 
1 428 VAL n 
1 429 ARG n 
1 430 PHE n 
1 431 MET n 
1 432 ASN n 
1 433 ILE n 
1 434 ASP n 
1 435 GLU n 
1 436 LYS n 
1 437 ALA n 
1 438 ILE n 
1 439 ILE n 
1 440 SER n 
1 441 TYR n 
1 442 LEU n 
1 443 VAL n 
1 444 SER n 
1 445 THR n 
1 446 TYR n 
1 447 TYR n 
1 448 SER n 
1 449 ALA n 
1 450 ALA n 
1 451 ILE n 
1 452 LEU n 
1 453 VAL n 
1 454 PRO n 
1 455 ASP n 
1 456 ALA n 
1 457 VAL n 
1 458 GLY n 
1 459 VAL n 
1 460 LEU n 
1 461 GLU n 
1 462 ASN n 
1 463 VAL n 
1 464 GLN n 
1 465 ILE n 
1 466 ALA n 
1 467 ASN n 
1 468 TRP n 
1 469 PRO n 
1 470 ARG n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   470 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'mmpI_1, NCTC13033_02226' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Streptomyces griseus subsp. griseus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     67263 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 23345 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CA  non-polymer         . 'CALCIUM ION'   ? 'Ca 2'           40.078  
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   THR 2   2   ?   ?   ?   A . n 
A 1 3   VAL 3   3   ?   ?   ?   A . n 
A 1 4   ASP 4   4   ?   ?   ?   A . n 
A 1 5   SER 5   5   ?   ?   ?   A . n 
A 1 6   THR 6   6   ?   ?   ?   A . n 
A 1 7   SER 7   7   ?   ?   ?   A . n 
A 1 8   GLU 8   8   ?   ?   ?   A . n 
A 1 9   ALA 9   9   ?   ?   ?   A . n 
A 1 10  ARG 10  10  ?   ?   ?   A . n 
A 1 11  LEU 11  11  ?   ?   ?   A . n 
A 1 12  GLU 12  12  ?   ?   ?   A . n 
A 1 13  VAL 13  13  ?   ?   ?   A . n 
A 1 14  PRO 14  14  ?   ?   ?   A . n 
A 1 15  ARG 15  15  ?   ?   ?   A . n 
A 1 16  GLN 16  16  ?   ?   ?   A . n 
A 1 17  SER 17  17  ?   ?   ?   A . n 
A 1 18  SER 18  18  ?   ?   ?   A . n 
A 1 19  LEU 19  19  ?   ?   ?   A . n 
A 1 20  GLY 20  20  ?   ?   ?   A . n 
A 1 21  THR 21  21  ?   ?   ?   A . n 
A 1 22  ALA 22  22  ?   ?   ?   A . n 
A 1 23  ALA 23  23  ?   ?   ?   A . n 
A 1 24  ALA 24  24  ?   ?   ?   A . n 
A 1 25  ARG 25  25  ?   ?   ?   A . n 
A 1 26  ASN 26  26  ?   ?   ?   A . n 
A 1 27  LEU 27  27  ?   ?   ?   A . n 
A 1 28  ALA 28  28  ?   ?   ?   A . n 
A 1 29  SER 29  29  ?   ?   ?   A . n 
A 1 30  THR 30  30  ?   ?   ?   A . n 
A 1 31  THR 31  31  ?   ?   ?   A . n 
A 1 32  LYS 32  32  ?   ?   ?   A . n 
A 1 33  SER 33  33  ?   ?   ?   A . n 
A 1 34  ALA 34  34  ?   ?   ?   A . n 
A 1 35  PRO 35  35  ?   ?   ?   A . n 
A 1 36  GLN 36  36  ?   ?   ?   A . n 
A 1 37  MET 37  37  ?   ?   ?   A . n 
A 1 38  GLN 38  38  ?   ?   ?   A . n 
A 1 39  GLU 39  39  ?   ?   ?   A . n 
A 1 40  ILE 40  40  40  ILE ILE A . n 
A 1 41  THR 41  41  41  THR THR A . n 
A 1 42  SER 42  42  42  SER SER A . n 
A 1 43  ARG 43  43  43  ARG ARG A . n 
A 1 44  TRP 44  44  44  TRP TRP A . n 
A 1 45  LEU 45  45  45  LEU LEU A . n 
A 1 46  LEU 46  46  46  LEU LEU A . n 
A 1 47  ARG 47  47  47  ARG ARG A . n 
A 1 48  MET 48  48  48  MET MET A . n 
A 1 49  LEU 49  49  49  LEU LEU A . n 
A 1 50  PRO 50  50  50  PRO PRO A . n 
A 1 51  TRP 51  51  51  TRP TRP A . n 
A 1 52  VAL 52  52  52  VAL VAL A . n 
A 1 53  GLU 53  53  53  GLU GLU A . n 
A 1 54  THR 54  54  54  THR THR A . n 
A 1 55  LYS 55  55  55  LYS LYS A . n 
A 1 56  GLY 56  56  56  GLY GLY A . n 
A 1 57  GLY 57  57  57  GLY GLY A . n 
A 1 58  ALA 58  58  58  ALA ALA A . n 
A 1 59  TYR 59  59  59  TYR TYR A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  VAL 61  61  61  VAL VAL A . n 
A 1 62  ASN 62  62  62  ASN ASN A . n 
A 1 63  ARG 63  63  63  ARG ARG A . n 
A 1 64  ARG 64  64  64  ARG ARG A . n 
A 1 65  LEU 65  65  65  LEU LEU A . n 
A 1 66  THR 66  66  66  THR THR A . n 
A 1 67  PHE 67  67  67  PHE PHE A . n 
A 1 68  THR 68  68  68  THR THR A . n 
A 1 69  VAL 69  69  69  VAL VAL A . n 
A 1 70  GLY 70  70  70  GLY GLY A . n 
A 1 71  ASP 71  71  71  ASP ASP A . n 
A 1 72  GLY 72  72  72  GLY GLY A . n 
A 1 73  ARG 73  73  73  ARG ARG A . n 
A 1 74  VAL 74  74  74  VAL VAL A . n 
A 1 75  GLU 75  75  75  GLU GLU A . n 
A 1 76  PHE 76  76  76  PHE PHE A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  GLN 78  78  78  GLN GLN A . n 
A 1 79  ASP 79  79  79  ASP ASP A . n 
A 1 80  GLY 80  80  80  GLY GLY A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  THR 82  82  82  THR THR A . n 
A 1 83  VAL 83  83  83  VAL VAL A . n 
A 1 84  ARG 84  84  84  ARG ARG A . n 
A 1 85  VAL 85  85  85  VAL VAL A . n 
A 1 86  ILE 86  86  86  ILE ILE A . n 
A 1 87  PRO 87  87  87  PRO PRO A . n 
A 1 88  GLN 88  88  88  GLN GLN A . n 
A 1 89  GLU 89  89  89  GLU GLU A . n 
A 1 90  LEU 90  90  90  LEU LEU A . n 
A 1 91  GLY 91  91  91  GLY GLY A . n 
A 1 92  GLU 92  92  92  GLU GLU A . n 
A 1 93  LEU 93  93  93  LEU LEU A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  LEU 95  95  95  LEU LEU A . n 
A 1 96  LEU 96  96  96  LEU LEU A . n 
A 1 97  ARG 97  97  97  ARG ARG A . n 
A 1 98  ASP 98  98  98  ASP ASP A . n 
A 1 99  PHE 99  99  99  PHE PHE A . n 
A 1 100 ASP 100 100 100 ASP ASP A . n 
A 1 101 ASP 101 101 101 ASP ASP A . n 
A 1 102 ALA 102 102 102 ALA ALA A . n 
A 1 103 GLU 103 103 103 GLU GLU A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 LEU 105 105 105 LEU LEU A . n 
A 1 106 SER 106 106 106 SER SER A . n 
A 1 107 ALA 107 107 107 ALA ALA A . n 
A 1 108 ILE 108 108 108 ILE ILE A . n 
A 1 109 ALA 109 109 109 ALA ALA A . n 
A 1 110 ASP 110 110 110 ASP ASP A . n 
A 1 111 ARG 111 111 111 ARG ARG A . n 
A 1 112 CYS 112 112 112 CYS CYS A . n 
A 1 113 VAL 113 113 113 VAL VAL A . n 
A 1 114 GLN 114 114 114 GLN GLN A . n 
A 1 115 ARG 115 115 115 ARG ARG A . n 
A 1 116 ASP 116 116 116 ASP ASP A . n 
A 1 117 PHE 117 117 117 PHE PHE A . n 
A 1 118 ARG 118 118 118 ARG ARG A . n 
A 1 119 ALA 119 119 119 ALA ALA A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 GLU 121 121 121 GLU GLU A . n 
A 1 122 THR 122 122 122 THR THR A . n 
A 1 123 LEU 123 123 123 LEU LEU A . n 
A 1 124 VAL 124 124 124 VAL VAL A . n 
A 1 125 GLU 125 125 125 GLU GLU A . n 
A 1 126 ARG 126 126 126 ARG ARG A . n 
A 1 127 GLY 127 127 127 GLY GLY A . n 
A 1 128 THR 128 128 128 THR THR A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 ALA 130 130 130 ALA ALA A . n 
A 1 131 ASP 131 131 131 ASP ASP A . n 
A 1 132 GLU 132 132 132 GLU GLU A . n 
A 1 133 LEU 133 133 133 LEU LEU A . n 
A 1 134 HIS 134 134 134 HIS HIS A . n 
A 1 135 LEU 135 135 135 LEU LEU A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 ALA 137 137 137 ALA ALA A . n 
A 1 138 HIS 138 138 138 HIS HIS A . n 
A 1 139 GLY 139 139 139 GLY GLY A . n 
A 1 140 ARG 140 140 140 ARG ARG A . n 
A 1 141 ILE 141 141 141 ILE ILE A . n 
A 1 142 GLY 142 142 142 GLY GLY A . n 
A 1 143 GLN 143 143 143 GLN GLN A . n 
A 1 144 ALA 144 144 144 ALA ALA A . n 
A 1 145 SER 145 145 145 SER SER A . n 
A 1 146 ALA 146 146 146 ALA ALA A . n 
A 1 147 GLY 147 147 ?   ?   ?   A . n 
A 1 148 SER 148 148 ?   ?   ?   A . n 
A 1 149 TYR 149 149 ?   ?   ?   A . n 
A 1 150 GLY 150 150 ?   ?   ?   A . n 
A 1 151 ASP 151 151 ?   ?   ?   A . n 
A 1 152 GLU 152 152 ?   ?   ?   A . n 
A 1 153 VAL 153 153 153 VAL VAL A . n 
A 1 154 THR 154 154 154 THR THR A . n 
A 1 155 LEU 155 155 155 LEU LEU A . n 
A 1 156 ASP 156 156 156 ASP ASP A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 LEU 158 158 158 LEU LEU A . n 
A 1 159 ALA 159 159 159 ALA ALA A . n 
A 1 160 ASP 160 160 160 ASP ASP A . n 
A 1 161 GLY 161 161 161 GLY GLY A . n 
A 1 162 ASP 162 162 162 ASP ASP A . n 
A 1 163 ARG 163 163 163 ARG ARG A . n 
A 1 164 PHE 164 164 164 PHE PHE A . n 
A 1 165 GLY 165 165 165 GLY GLY A . n 
A 1 166 GLU 166 166 166 GLU GLU A . n 
A 1 167 HIS 167 167 167 HIS HIS A . n 
A 1 168 ALA 168 168 168 ALA ALA A . n 
A 1 169 LEU 169 169 169 LEU LEU A . n 
A 1 170 LEU 170 170 170 LEU LEU A . n 
A 1 171 ASP 171 171 171 ASP ASP A . n 
A 1 172 GLU 172 172 172 GLU GLU A . n 
A 1 173 ASP 173 173 173 ASP ASP A . n 
A 1 174 ALA 174 174 174 ALA ALA A . n 
A 1 175 ARG 175 175 175 ARG ARG A . n 
A 1 176 TRP 176 176 176 TRP TRP A . n 
A 1 177 SER 177 177 177 SER SER A . n 
A 1 178 GLN 178 178 178 GLN GLN A . n 
A 1 179 THR 179 179 179 THR THR A . n 
A 1 180 ALA 180 180 180 ALA ALA A . n 
A 1 181 THR 181 181 181 THR THR A . n 
A 1 182 ALA 182 182 182 ALA ALA A . n 
A 1 183 GLU 183 183 183 GLU GLU A . n 
A 1 184 THR 184 184 184 THR THR A . n 
A 1 185 SER 185 185 185 SER SER A . n 
A 1 186 GLY 186 186 186 GLY GLY A . n 
A 1 187 THR 187 187 187 THR THR A . n 
A 1 188 LEU 188 188 188 LEU LEU A . n 
A 1 189 LEU 189 189 189 LEU LEU A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 LEU 191 191 191 LEU LEU A . n 
A 1 192 SER 192 192 192 SER SER A . n 
A 1 193 ARG 193 193 193 ARG ARG A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 ASP 195 195 195 ASP ASP A . n 
A 1 196 PHE 196 196 196 PHE PHE A . n 
A 1 197 ALA 197 197 197 ALA ALA A . n 
A 1 198 ALA 198 198 198 ALA ALA A . n 
A 1 199 VAL 199 199 199 VAL VAL A . n 
A 1 200 VAL 200 200 200 VAL VAL A . n 
A 1 201 ALA 201 201 201 ALA ALA A . n 
A 1 202 ASN 202 202 202 ASN ASN A . n 
A 1 203 SER 203 203 203 SER SER A . n 
A 1 204 PRO 204 204 204 PRO PRO A . n 
A 1 205 ALA 205 205 205 ALA ALA A . n 
A 1 206 LEU 206 206 206 LEU LEU A . n 
A 1 207 ARG 207 207 207 ARG ARG A . n 
A 1 208 SER 208 208 208 SER SER A . n 
A 1 209 HIS 209 209 209 HIS HIS A . n 
A 1 210 LEU 210 210 210 LEU LEU A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 ALA 212 212 212 ALA ALA A . n 
A 1 213 PHE 213 213 213 PHE PHE A . n 
A 1 214 THR 214 214 214 THR THR A . n 
A 1 215 ALA 215 215 215 ALA ALA A . n 
A 1 216 ARG 216 216 ?   ?   ?   A . n 
A 1 217 SER 217 217 ?   ?   ?   A . n 
A 1 218 GLU 218 218 ?   ?   ?   A . n 
A 1 219 GLN 219 219 ?   ?   ?   A . n 
A 1 220 ARG 220 220 ?   ?   ?   A . n 
A 1 221 GLN 221 221 ?   ?   ?   A . n 
A 1 222 ASN 222 222 ?   ?   ?   A . n 
A 1 223 HIS 223 223 ?   ?   ?   A . n 
A 1 224 ARG 224 224 ?   ?   ?   A . n 
A 1 225 GLY 225 225 ?   ?   ?   A . n 
A 1 226 GLU 226 226 ?   ?   ?   A . n 
A 1 227 ALA 227 227 ?   ?   ?   A . n 
A 1 228 GLU 228 228 ?   ?   ?   A . n 
A 1 229 ILE 229 229 ?   ?   ?   A . n 
A 1 230 ALA 230 230 ?   ?   ?   A . n 
A 1 231 MET 231 231 ?   ?   ?   A . n 
A 1 232 SER 232 232 ?   ?   ?   A . n 
A 1 233 ALA 233 233 ?   ?   ?   A . n 
A 1 234 GLY 234 234 ?   ?   ?   A . n 
A 1 235 HIS 235 235 ?   ?   ?   A . n 
A 1 236 VAL 236 236 ?   ?   ?   A . n 
A 1 237 GLY 237 237 ?   ?   ?   A . n 
A 1 238 GLU 238 238 ?   ?   ?   A . n 
A 1 239 HIS 239 239 ?   ?   ?   A . n 
A 1 240 GLU 240 240 ?   ?   ?   A . n 
A 1 241 LEU 241 241 ?   ?   ?   A . n 
A 1 242 PRO 242 242 ?   ?   ?   A . n 
A 1 243 GLY 243 243 ?   ?   ?   A . n 
A 1 244 ALA 244 244 ?   ?   ?   A . n 
A 1 245 PHE 245 245 ?   ?   ?   A . n 
A 1 246 ALA 246 246 246 ALA ALA A . n 
A 1 247 ASP 247 247 247 ASP ASP A . n 
A 1 248 TYR 248 248 248 TYR TYR A . n 
A 1 249 GLU 249 249 249 GLU GLU A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 LYS 251 251 251 LYS LYS A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 ARG 253 253 253 ARG ARG A . n 
A 1 254 GLU 254 254 254 GLU GLU A . n 
A 1 255 TYR 255 255 255 TYR TYR A . n 
A 1 256 GLU 256 256 256 GLU GLU A . n 
A 1 257 LEU 257 257 257 LEU LEU A . n 
A 1 258 SER 258 258 258 SER SER A . n 
A 1 259 VAL 259 259 259 VAL VAL A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 GLN 261 261 261 GLN GLN A . n 
A 1 262 THR 262 262 262 THR THR A . n 
A 1 263 ILE 263 263 263 ILE ILE A . n 
A 1 264 LEU 264 264 264 LEU LEU A . n 
A 1 265 ARG 265 265 265 ARG ARG A . n 
A 1 266 VAL 266 266 266 VAL VAL A . n 
A 1 267 HIS 267 267 267 HIS HIS A . n 
A 1 268 THR 268 268 268 THR THR A . n 
A 1 269 ARG 269 269 269 ARG ARG A . n 
A 1 270 VAL 270 270 270 VAL VAL A . n 
A 1 271 ALA 271 271 271 ALA ALA A . n 
A 1 272 ASP 272 272 272 ASP ASP A . n 
A 1 273 LEU 273 273 273 LEU LEU A . n 
A 1 274 TYR 274 274 274 TYR TYR A . n 
A 1 275 ASN 275 275 275 ASN ASN A . n 
A 1 276 GLY 276 276 276 GLY GLY A . n 
A 1 277 PRO 277 277 277 PRO PRO A . n 
A 1 278 MET 278 278 278 MET MET A . n 
A 1 279 ASN 279 279 279 ASN ASN A . n 
A 1 280 GLN 280 280 280 GLN GLN A . n 
A 1 281 THR 281 281 281 THR THR A . n 
A 1 282 GLU 282 282 282 GLU GLU A . n 
A 1 283 GLU 283 283 283 GLU GLU A . n 
A 1 284 GLN 284 284 284 GLN GLN A . n 
A 1 285 LEU 285 285 285 LEU LEU A . n 
A 1 286 ARG 286 286 286 ARG ARG A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 THR 288 288 288 THR THR A . n 
A 1 289 ILE 289 289 289 ILE ILE A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 ALA 291 291 291 ALA ALA A . n 
A 1 292 LEU 292 292 292 LEU LEU A . n 
A 1 293 ARG 293 293 293 ARG ARG A . n 
A 1 294 GLU 294 294 294 GLU GLU A . n 
A 1 295 ARG 295 295 295 ARG ARG A . n 
A 1 296 GLN 296 296 296 GLN GLN A . n 
A 1 297 GLU 297 297 297 GLU GLU A . n 
A 1 298 HIS 298 298 298 HIS HIS A . n 
A 1 299 GLU 299 299 299 GLU GLU A . n 
A 1 300 LEU 300 300 300 LEU LEU A . n 
A 1 301 ILE 301 301 301 ILE ILE A . n 
A 1 302 ASN 302 302 302 ASN ASN A . n 
A 1 303 ASN 303 303 303 ASN ASN A . n 
A 1 304 ARG 304 304 304 ARG ARG A . n 
A 1 305 GLU 305 305 305 GLU GLU A . n 
A 1 306 PHE 306 306 306 PHE PHE A . n 
A 1 307 GLY 307 307 307 GLY GLY A . n 
A 1 308 LEU 308 308 308 LEU LEU A . n 
A 1 309 LEU 309 309 309 LEU LEU A . n 
A 1 310 HIS 310 310 310 HIS HIS A . n 
A 1 311 ASN 311 311 311 ASN ASN A . n 
A 1 312 ALA 312 312 312 ALA ALA A . n 
A 1 313 ASP 313 313 313 ASP ASP A . n 
A 1 314 PHE 314 314 314 PHE PHE A . n 
A 1 315 LYS 315 315 315 LYS LYS A . n 
A 1 316 GLN 316 316 316 GLN GLN A . n 
A 1 317 ARG 317 317 317 ARG ARG A . n 
A 1 318 ILE 318 318 318 ILE ILE A . n 
A 1 319 GLN 319 319 319 GLN GLN A . n 
A 1 320 THR 320 320 320 THR THR A . n 
A 1 321 HIS 321 321 321 HIS HIS A . n 
A 1 322 SER 322 322 322 SER SER A . n 
A 1 323 GLY 323 323 323 GLY GLY A . n 
A 1 324 PRO 324 324 324 PRO PRO A . n 
A 1 325 PRO 325 325 325 PRO PRO A . n 
A 1 326 THR 326 326 326 THR THR A . n 
A 1 327 PRO 327 327 327 PRO PRO A . n 
A 1 328 ASP 328 328 328 ASP ASP A . n 
A 1 329 ASP 329 329 329 ASP ASP A . n 
A 1 330 LEU 330 330 330 LEU LEU A . n 
A 1 331 ASP 331 331 331 ASP ASP A . n 
A 1 332 GLU 332 332 332 GLU GLU A . n 
A 1 333 LEU 333 333 333 LEU LEU A . n 
A 1 334 LEU 334 334 334 LEU LEU A . n 
A 1 335 CYS 335 335 335 CYS CYS A . n 
A 1 336 ARG 336 336 336 ARG ARG A . n 
A 1 337 ARG 337 337 337 ARG ARG A . n 
A 1 338 ARG 338 338 338 ARG ARG A . n 
A 1 339 GLY 339 339 339 GLY GLY A . n 
A 1 340 THR 340 340 340 THR THR A . n 
A 1 341 LYS 341 341 341 LYS LYS A . n 
A 1 342 PHE 342 342 342 PHE PHE A . n 
A 1 343 PHE 343 343 343 PHE PHE A . n 
A 1 344 LEU 344 344 344 LEU LEU A . n 
A 1 345 ALA 345 345 345 ALA ALA A . n 
A 1 346 HIS 346 346 346 HIS HIS A . n 
A 1 347 PRO 347 347 347 PRO PRO A . n 
A 1 348 ARG 348 348 348 ARG ARG A . n 
A 1 349 THR 349 349 349 THR THR A . n 
A 1 350 ILE 350 350 350 ILE ILE A . n 
A 1 351 ALA 351 351 351 ALA ALA A . n 
A 1 352 ALA 352 352 352 ALA ALA A . n 
A 1 353 MET 353 353 353 MET MET A . n 
A 1 354 GLY 354 354 354 GLY GLY A . n 
A 1 355 ARG 355 355 355 ARG ARG A . n 
A 1 356 GLU 356 356 356 GLU GLU A . n 
A 1 357 PHE 357 357 357 PHE PHE A . n 
A 1 358 ASN 358 358 358 ASN ASN A . n 
A 1 359 ALA 359 359 359 ALA ALA A . n 
A 1 360 ARG 360 360 360 ARG ARG A . n 
A 1 361 GLY 361 361 361 GLY GLY A . n 
A 1 362 LEU 362 362 362 LEU LEU A . n 
A 1 363 TYR 363 363 363 TYR TYR A . n 
A 1 364 PRO 364 364 364 PRO PRO A . n 
A 1 365 ASP 365 365 365 ASP ASP A . n 
A 1 366 HIS 366 366 366 HIS HIS A . n 
A 1 367 THR 367 367 367 THR THR A . n 
A 1 368 ASP 368 368 368 ASP ASP A . n 
A 1 369 LEU 369 369 369 LEU LEU A . n 
A 1 370 GLY 370 370 370 GLY GLY A . n 
A 1 371 GLY 371 371 371 GLY GLY A . n 
A 1 372 GLN 372 372 372 GLN GLN A . n 
A 1 373 GLN 373 373 373 GLN GLN A . n 
A 1 374 VAL 374 374 374 VAL VAL A . n 
A 1 375 PRO 375 375 375 PRO PRO A . n 
A 1 376 ALA 376 376 376 ALA ALA A . n 
A 1 377 TRP 377 377 377 TRP TRP A . n 
A 1 378 ARG 378 378 378 ARG ARG A . n 
A 1 379 GLY 379 379 379 GLY GLY A . n 
A 1 380 VAL 380 380 380 VAL VAL A . n 
A 1 381 PRO 381 381 381 PRO PRO A . n 
A 1 382 ILE 382 382 382 ILE ILE A . n 
A 1 383 LEU 383 383 383 LEU LEU A . n 
A 1 384 PRO 384 384 384 PRO PRO A . n 
A 1 385 CYS 385 385 385 CYS CYS A . n 
A 1 386 GLY 386 386 386 GLY GLY A . n 
A 1 387 LYS 387 387 387 LYS LYS A . n 
A 1 388 ILE 388 388 388 ILE ILE A . n 
A 1 389 PRO 389 389 389 PRO PRO A . n 
A 1 390 ILE 390 390 390 ILE ILE A . n 
A 1 391 THR 391 391 391 THR THR A . n 
A 1 392 PRO 392 392 392 PRO PRO A . n 
A 1 393 GLU 393 393 393 GLU GLU A . n 
A 1 394 ARG 394 394 394 ARG ARG A . n 
A 1 395 THR 395 395 395 THR THR A . n 
A 1 396 SER 396 396 396 SER SER A . n 
A 1 397 SER 397 397 397 SER SER A . n 
A 1 398 ILE 398 398 398 ILE ILE A . n 
A 1 399 LEU 399 399 399 LEU LEU A . n 
A 1 400 ALA 400 400 400 ALA ALA A . n 
A 1 401 LEU 401 401 401 LEU LEU A . n 
A 1 402 ARG 402 402 402 ARG ARG A . n 
A 1 403 THR 403 403 403 THR THR A . n 
A 1 404 GLY 404 404 404 GLY GLY A . n 
A 1 405 GLU 405 405 405 GLU GLU A . n 
A 1 406 GLU 406 406 406 GLU GLU A . n 
A 1 407 ASP 407 407 407 ASP ASP A . n 
A 1 408 GLN 408 408 408 GLN GLN A . n 
A 1 409 GLY 409 409 409 GLY GLY A . n 
A 1 410 VAL 410 410 410 VAL VAL A . n 
A 1 411 ILE 411 411 411 ILE ILE A . n 
A 1 412 GLY 412 412 412 GLY GLY A . n 
A 1 413 LEU 413 413 413 LEU LEU A . n 
A 1 414 ARG 414 414 414 ARG ARG A . n 
A 1 415 GLN 415 415 415 GLN GLN A . n 
A 1 416 THR 416 416 416 THR THR A . n 
A 1 417 GLY 417 417 417 GLY GLY A . n 
A 1 418 LEU 418 418 418 LEU LEU A . n 
A 1 419 PRO 419 419 419 PRO PRO A . n 
A 1 420 ASP 420 420 420 ASP ASP A . n 
A 1 421 GLU 421 421 421 GLU GLU A . n 
A 1 422 TYR 422 422 422 TYR TYR A . n 
A 1 423 GLU 423 423 423 GLU GLU A . n 
A 1 424 PRO 424 424 424 PRO PRO A . n 
A 1 425 GLY 425 425 425 GLY GLY A . n 
A 1 426 LEU 426 426 426 LEU LEU A . n 
A 1 427 SER 427 427 427 SER SER A . n 
A 1 428 VAL 428 428 428 VAL VAL A . n 
A 1 429 ARG 429 429 429 ARG ARG A . n 
A 1 430 PHE 430 430 430 PHE PHE A . n 
A 1 431 MET 431 431 431 MET MET A . n 
A 1 432 ASN 432 432 432 ASN ASN A . n 
A 1 433 ILE 433 433 433 ILE ILE A . n 
A 1 434 ASP 434 434 434 ASP ASP A . n 
A 1 435 GLU 435 435 435 GLU GLU A . n 
A 1 436 LYS 436 436 436 LYS LYS A . n 
A 1 437 ALA 437 437 437 ALA ALA A . n 
A 1 438 ILE 438 438 438 ILE ILE A . n 
A 1 439 ILE 439 439 439 ILE ILE A . n 
A 1 440 SER 440 440 440 SER SER A . n 
A 1 441 TYR 441 441 441 TYR TYR A . n 
A 1 442 LEU 442 442 442 LEU LEU A . n 
A 1 443 VAL 443 443 443 VAL VAL A . n 
A 1 444 SER 444 444 444 SER SER A . n 
A 1 445 THR 445 445 445 THR THR A . n 
A 1 446 TYR 446 446 446 TYR TYR A . n 
A 1 447 TYR 447 447 447 TYR TYR A . n 
A 1 448 SER 448 448 448 SER SER A . n 
A 1 449 ALA 449 449 449 ALA ALA A . n 
A 1 450 ALA 450 450 450 ALA ALA A . n 
A 1 451 ILE 451 451 451 ILE ILE A . n 
A 1 452 LEU 452 452 452 LEU LEU A . n 
A 1 453 VAL 453 453 453 VAL VAL A . n 
A 1 454 PRO 454 454 454 PRO PRO A . n 
A 1 455 ASP 455 455 455 ASP ASP A . n 
A 1 456 ALA 456 456 456 ALA ALA A . n 
A 1 457 VAL 457 457 457 VAL VAL A . n 
A 1 458 GLY 458 458 458 GLY GLY A . n 
A 1 459 VAL 459 459 459 VAL VAL A . n 
A 1 460 LEU 460 460 460 LEU LEU A . n 
A 1 461 GLU 461 461 461 GLU GLU A . n 
A 1 462 ASN 462 462 462 ASN ASN A . n 
A 1 463 VAL 463 463 463 VAL VAL A . n 
A 1 464 GLN 464 464 464 GLN GLN A . n 
A 1 465 ILE 465 465 465 ILE ILE A . n 
A 1 466 ALA 466 466 466 ALA ALA A . n 
A 1 467 ASN 467 467 467 ASN ASN A . n 
A 1 468 TRP 468 468 468 TRP TRP A . n 
A 1 469 PRO 469 469 469 PRO PRO A . n 
A 1 470 ARG 470 470 470 ARG ARG A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        CA 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   CA 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
_pdbx_nonpoly_scheme.asym_id         B 
_pdbx_nonpoly_scheme.entity_id       2 
_pdbx_nonpoly_scheme.mon_id          CA 
_pdbx_nonpoly_scheme.ndb_seq_num     1 
_pdbx_nonpoly_scheme.pdb_seq_num     501 
_pdbx_nonpoly_scheme.auth_seq_num    1 
_pdbx_nonpoly_scheme.pdb_mon_id      CA 
_pdbx_nonpoly_scheme.auth_mon_id     CA 
_pdbx_nonpoly_scheme.pdb_strand_id   A 
_pdbx_nonpoly_scheme.pdb_ins_code    . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BHU 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BHU 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BHU 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     9BHU 
_struct.title                        'Streptomyces griseus Family 2B encapsulin shell' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BHU 
_struct_keywords.text            'Encapsulin, nanocompartment, VIRUS LIKE PARTICLE' 
_struct_keywords.pdbx_keywords   'VIRUS LIKE PARTICLE' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q54255_STRGR 
_struct_ref.pdbx_db_accession          Q54255 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MTVDSTSEARLEVPRQSSLGTAAARNLASTTKSAPQMQEITSRWLLRMLPWVETKGGAYRVNRRLTFTVGDGRVEFVQDG
STVRVIPQELGELALLRDFDDAEVLSAIADRCVQRDFRAGETLVERGTAADELHLIAHGRIGQASAGSYGDEVTLDVLAD
GDRFGEHALLDEDARWSQTATAETSGTLLTLSRADFAAVVANSPALRSHLAAFTARSEQRQNHRGEAEIAMSAGHVGEHE
LPGAFADYELKPREYELSVAQTILRVHTRVADLYNGPMNQTEEQLRLTIEALRERQEHELINNREFGLLHNADFKQRIQT
HSGPPTPDDLDELLCRRRGTKFFLAHPRTIAAMGREFNARGLYPDHTDLGGQQVPAWRGVPILPCGKIPITPERTSSILA
LRTGEEDQGVIGLRQTGLPDEYEPGLSVRFMNIDEKAIISYLVSTYYSAAILVPDAVGVLENVQIANWPR
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9BHU 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 470 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q54255 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  470 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       470 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 'complete icosahedral assembly'                ? 60-meric   60 
2 'icosahedral asymmetric unit'                  ? monomeric  1  
3 'icosahedral pentamer'                         ? pentameric 5  
4 'icosahedral 23 hexamer'                       ? hexameric  6  
5 'icosahedral asymmetric unit, std point frame' ? monomeric  1  
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 '(1-60)'           A,B 
2 1                  A,B 
3 '(1-5)'            A,B 
4 '(1,2,6,10,23,24)' A,B 
5 P                  A,B 
# 
loop_
_pdbx_struct_assembly_auth_evidence.id 
_pdbx_struct_assembly_auth_evidence.assembly_id 
_pdbx_struct_assembly_auth_evidence.experimental_support 
_pdbx_struct_assembly_auth_evidence.details 
1 1 'electron microscopy'        ? 
2 1 'gel filtration'             ? 
3 1 'native gel electrophoresis' ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
P  'transform to point frame' ?     ?     1.00000000  -0.00001968 0.00001225  -200.19664 0.00001968  1.00000000  -0.00002822 
-200.19716 -0.00001225 0.00002822  1.00000000  -200.20336 
1  'identity operation'       1_555 x,y,z 1.00000000  0.00000000  0.00000000  0.00000    0.00000000  1.00000000  0.00000000  
0.00000    0.00000000  0.00000000  1.00000000  0.00000    
2  'point symmetry operation' ?     ?     0.30901699  -0.80900291 0.50002279  200.19033  0.80900286  0.50001744  0.30902578  
-123.73193 -0.50002287 0.30902564  0.80899955  76.47538   
3  'point symmetry operation' ?     ?     -0.80901699 -0.49999135 0.30903099  400.39146  0.49999121  -0.30897133 0.80903987  
-0.01264   -0.30903122 0.80903978  0.49995434  0.00784    
4  'point symmetry operation' ?     ?     -0.80901699 0.49999121  -0.30903122 323.93224  -0.49999135 -0.30897133 0.80903978  
200.18202  0.30903099  0.80903987  0.49995434  -123.72707 
5  'point symmetry operation' ?     ?     0.30901699  0.80900286  -0.50002287 76.47671   -0.80900291 0.50001744  0.30902564  
200.18983  0.50002279  0.30902578  0.80899955  -123.73192 
6  'point symmetry operation' ?     ?     -1.00000000 0.00000000  -0.00002450 400.40116  0.00000000  -1.00000000 0.00005644  
400.38644  -0.00002450 0.00005644  1.00000000  -0.00639   
7  'point symmetry operation' ?     ?     -0.30900474 0.80899534  -0.50004261 200.20896  -0.80903108 -0.50000000 -0.30898012 
524.12268  -0.49998478 0.30907369  0.80900474  76.45710   
8  'point symmetry operation' ?     ?     0.80902456  0.49997153  -0.30904324 0.00970    -0.50000865 0.30901700  -0.80901165 
400.39908  -0.30898318 0.80903459  0.49999243  -0.00836   
9  'point symmetry operation' ?     ?     0.80900942  -0.50001103 0.30901897  76.47195   0.50000879  0.30901699  -0.80901156 
200.19744  0.30902259  0.80901018  0.50000757  -123.73010 
10 'point symmetry operation' ?     ?     -0.30902924 -0.80901043 0.50000305  323.92748  0.80903113  -0.50000000 -0.30897998 
200.18963  0.49996955  0.30903418  0.80902924  -123.72889 
11 'point symmetry operation' ?     ?     -1.00000000 0.00003936  0.00000000  400.38838  0.00003936  1.00000000  -0.00005644 
0.00342    0.00000000  -0.00005644 -1.00000000 400.41162  
12 'point symmetry operation' ?     ?     -0.30898515 0.80902259  -0.50001062 200.19318  0.80904324  0.49996816  0.30899980  
-123.72494 0.49997721  -0.30905386 -0.80901699 323.94323  
13 'point symmetry operation' ?     ?     0.80903667  0.49997919  -0.30899915 -0.00309   0.49997681  -0.30903667 0.80902381  
0.00654    0.30900300  -0.80902234 -0.50000000 400.40378  
14 'point symmetry operation' ?     ?     0.80899731  -0.50000337 0.30906306  76.46401   -0.50004063 -0.30899731 0.80899940  
200.20517  -0.30900277 -0.80902243 -0.50000000 524.12740  
15 'point symmetry operation' ?     ?     -0.30904884 -0.80898318 0.50003504  323.91955  -0.80901897 0.50003184  0.30896030  
200.20324  -0.49997713 -0.30905401 -0.80901699 524.13224  
16 'point symmetry operation' ?     ?     1.00000000  -0.00003936 0.00002450  0.00298    -0.00003936 -1.00000000 0.00000000  
400.40562  0.00002450  0.00000000  -1.00000000 400.39542  
17 'point symmetry operation' ?     ?     0.30897290  -0.80901502 0.50003044  200.20005  -0.80901502 -0.49998560 -0.30904547 
524.12967  0.50003044  -0.30904547 -0.80898730 323.92495  
18 'point symmetry operation' ?     ?     -0.80904424 -0.49995937 0.30901140  400.39444  -0.49995937 0.30899101  -0.80905203 
400.40250  0.30901140  -0.80905203 -0.49994677 400.39739  
19 'point symmetry operation' ?     ?     -0.80898974 0.50002319  -0.30905081 323.92430  0.50002319  0.30895165  -0.80902762 
200.21085  -0.30905081 -0.80902762 -0.49996191 524.13043  
20 'point symmetry operation' ?     ?     0.30906109  0.80899075  -0.50001522 76.46877   0.80899075  -0.50004928 -0.30900596 
200.21278  -0.50001521 -0.30900596 -0.80901180 524.12921  
21 'point symmetry operation' ?     ?     0.00000743  0.00001597  1.00000000  -0.00672   1.00000000  0.00000854  -0.00000743 
0.00052    -0.00000854 1.00000000  -0.00001597 0.00620    
22 'point symmetry operation' ?     ?     -0.50000766 0.30902762  0.80900820  76.46817   0.30902762  -0.80900094 0.50001941  
200.18922  0.80900820  0.50001941  0.30900859  -123.72866 
23 'point symmetry operation' ?     ?     -0.30902924 0.80903113  0.49996956  0.00410    -0.80901043 -0.50000000 0.30903419  
400.39198  0.50000305  -0.30897998 0.80902924  -0.00985   
24 'point symmetry operation' ?     ?     0.30901699  0.80903865  0.49996496  -123.72819 -0.80902356 0.49998256  -0.30902802 
323.93539  -0.49998938 -0.30898852 0.80903444  200.18743  
25 'point symmetry operation' ?     ?     0.50001216  0.30903978  0.80900077  -123.73487 0.30900637  0.80900483  -0.50002625 
76.47986   -0.80901353 0.50000560  0.30901699  200.19735  
26 'point symmetry operation' ?     ?     -0.00003193 0.00004047  1.00000000  -0.00374   -1.00000000 -0.00000854 -0.00003193 
400.40510  0.00000854  -1.00000000 0.00004047  400.38922  
27 'point symmetry operation' ?     ?     -0.50000000 0.30907171  0.80899609  76.46023   -0.30900794 0.80898877  -0.50005126 
200.21339  -0.80902045 -0.50001184 -0.30898877 524.12595  
28 'point symmetry operation' ?     ?     -0.30898515 0.80904324  0.49997721  -0.00869   0.80902259  0.49996816  -0.30905386 
0.01364    -0.50001062 0.30899981  -0.80901699 400.40528  
29 'point symmetry operation' ?     ?     0.30903659  0.80901140  0.49999695  -123.73306 0.80901140  -0.50001440 0.30900834  
76.47510   0.49999695  0.30900834  -0.80902219 200.20496  
30 'point symmetry operation' ?     ?     0.49998018  0.30902019  0.80902802  -123.73000 -0.30902605 -0.80901699 0.49999440  
323.93063  0.80902579  -0.49999803 -0.30899717 200.19504  
31 'point symmetry operation' ?     ?     -0.00000743 -0.00004047 -1.00000000 400.40788  -1.00000000 0.00004790  0.00000743  
400.38592  0.00004790  1.00000000  -0.00004047 -0.00019   
32 'point symmetry operation' ?     ?     0.49998784  -0.30903987 -0.80901577 323.93602  -0.30898196 0.80902916  -0.50000197 
200.19023  0.80903789  0.49996618  0.30901699  -123.72563 
33 'point symmetry operation' ?     ?     0.30901700  -0.80902356 -0.49998938 400.39706  0.80903865  0.49998256  -0.30898852 
-0.00554   0.49996496  -0.30902802 0.80903443  0.00635    
34 'point symmetry operation' ?     ?     -0.30900474 -0.80903108 -0.49998478 524.12444  0.80899534  -0.50000000 0.30907368  
76.46235   -0.50004261 -0.30898012 0.80900474  200.20235  
35 'point symmetry operation' ?     ?     -0.49999234 -0.30905203 -0.80900834 524.13113  -0.30905203 -0.80897661 0.50004369  
323.91788  -0.80900834 0.50004369  0.30896895  200.19830  
36 'point symmetry operation' ?     ?     0.00003193  -0.00001597 -1.00000000 400.39510  1.00000000  -0.00004790 0.00003193  
0.00394    -0.00004790 -1.00000000 0.00001597  400.40542  
37 'point symmetry operation' ?     ?     0.50001982  -0.30905946 -0.80898852 323.92808  0.30896228  -0.80901699 0.50003382  
200.20264  -0.80902564 -0.49997375 -0.30903682 524.12898  
38 'point symmetry operation' ?     ?     0.30899740  -0.80905081 -0.49995739 400.40004  -0.80905081 -0.49995072 0.30900820  
400.39540  -0.49995739 0.30900820  -0.80904668 400.39888  
39 'point symmetry operation' ?     ?     -0.30904884 -0.80901897 -0.49997713 524.12931  -0.80898318 0.50003184  -0.30905401 
323.92264  0.50003504  0.30896030  -0.80901699 200.20592  
40 'point symmetry operation' ?     ?     -0.50000000 -0.30900794 -0.80902045 524.12626  0.30907171  0.80898877  -0.50001184 
76.46711   0.80899609  -0.50005126 -0.30898877 200.20996  
41 'point symmetry operation' ?     ?     0.00000743  1.00000000  -0.00000854 -0.00052   0.00001597  0.00000854  1.00000000  
-0.00620   1.00000000  -0.00000743 -0.00001597 0.00672    
42 'point symmetry operation' ?     ?     0.80900942  0.50000879  0.30902259  -123.73161 -0.50001103 0.30901699  0.80901018  
76.47132   0.30901897  -0.80901156 0.50000757  200.19675  
43 'point symmetry operation' ?     ?     0.49998784  -0.30898196 0.80903789  -0.01018   -0.30903987 0.80902916  0.49996618  
0.00804    -0.80901577 -0.50000197 0.30901700  400.39818  
44 'point symmetry operation' ?     ?     -0.50000000 -0.30897453 0.80903321  200.18496  0.30901380  0.80904521  0.49995631  
-123.72639 -0.80901821 0.49998058  -0.30904521 323.93945  
45 'point symmetry operation' ?     ?     -0.80900488 0.50002081  0.30901502  200.19093  0.50002081  0.30904297  0.80899421  
-123.73519 0.30901502  0.80899421  -0.50003809 76.48392   
46 'point symmetry operation' ?     ?     -0.00000743 -1.00000000 0.00004790  400.38889  -0.00004047 0.00004790  1.00000000  
-0.00278   -1.00000000 0.00000743  -0.00004047 400.40490  
47 'point symmetry operation' ?     ?     -0.80902910 -0.49999663 -0.30899075 524.12300  -0.49999663 0.30908233  0.80899412  
76.45857   -0.30899075 0.80899412  -0.50005323 200.21056  
48 'point symmetry operation' ?     ?     -0.50000000 0.30901380  -0.80901821 400.39856  -0.30897453 0.80904521  0.49998058  
-0.01114   0.80903321  0.49995631  -0.30904521 0.01344    
49 'point symmetry operation' ?     ?     0.50001216  0.30900637  -0.80901354 200.19854  0.30903978  0.80900483  0.50000560  
-123.73337 0.80900077  -0.50002625 0.30901699  76.47916   
50 'point symmetry operation' ?     ?     0.80902457  -0.50000865 -0.30898318 200.19257  0.49997153  0.30901699  0.80903459  
-123.72820 -0.30904324 -0.80901165 0.49999243  323.93469  
51 'point symmetry operation' ?     ?     0.00003193  1.00000000  -0.00004790 0.00246    -0.00001597 -0.00004790 -1.00000000 
400.41182  -1.00000000 0.00003193  0.00001597  400.38870  
52 'point symmetry operation' ?     ?     0.80903667  0.49997681  0.30900300  -123.72674 0.49997919  -0.30903667 -0.80902234 
323.93917  -0.30899915 0.80902381  -0.50000000 200.19564  
53 'point symmetry operation' ?     ?     0.49998018  -0.30902605 0.80902579  0.00260    0.30902019  -0.80901699 -0.49999803 
400.39758  0.80902802  0.49999440  -0.30899717 -0.00276   
54 'point symmetry operation' ?     ?     -0.50003198 -0.30899412 0.80900596  200.20074  -0.30899412 -0.80903305 -0.49998815 
524.12413  0.80900596  -0.49998816 0.30906503  76.46088   
55 'point symmetry operation' ?     ?     -0.80901699 0.50002847  0.30897093  200.20065  -0.49998897 -0.30906265 -0.80900637 
524.13293  -0.30903484 -0.80898196 0.50004566  323.91641  
56 'point symmetry operation' ?     ?     -0.00003193 -1.00000000 0.00000854  400.40168  0.00004047  -0.00000854 -1.00000000 
400.39264  1.00000000  -0.00003193 0.00004047  0.00033    
57 'point symmetry operation' ?     ?     -0.80901699 -0.49998897 -0.30903484 524.12787  0.50002847  -0.30906266 -0.80898196 
323.92642  0.30897093  -0.80900637 0.50004566  200.19770  
58 'point symmetry operation' ?     ?     -0.49996802 0.30899421  -0.80904546 400.40153  0.30899421  -0.80905738 -0.49994874 
400.40100  -0.80904546 -0.49994874 0.30902539  400.39179  
59 'point symmetry operation' ?     ?     0.50001982  0.30896228  -0.80902564 200.20826  -0.30905946 -0.80901699 -0.49997375 
524.13111  -0.80898852 0.50003382  -0.30903682 323.92117  
60 'point symmetry operation' ?     ?     0.80899731  -0.50004063 -0.30900277 200.20835  -0.50000337 -0.30899731 -0.80902243 
524.12594  0.30906306  0.80899940  -0.50000000 76.46563   
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ARG A 43  ? LEU A 49  ? ARG A 43  LEU A 49  1 ? 7  
HELX_P HELX_P2  AA2 PRO A 87  ? ARG A 97  ? PRO A 87  ARG A 97  5 ? 11 
HELX_P HELX_P3  AA3 ASP A 101 ? ARG A 111 ? ASP A 101 ARG A 111 1 ? 11 
HELX_P HELX_P4  AA4 GLU A 166 ? LEU A 170 ? GLU A 166 LEU A 170 5 ? 5  
HELX_P HELX_P5  AA5 ARG A 193 ? SER A 203 ? ARG A 193 SER A 203 1 ? 11 
HELX_P HELX_P6  AA6 SER A 203 ? ALA A 215 ? SER A 203 ALA A 215 1 ? 13 
HELX_P HELX_P7  AA7 THR A 268 ? LEU A 273 ? THR A 268 LEU A 273 1 ? 6  
HELX_P HELX_P8  AA8 ASN A 279 ? ASN A 303 ? ASN A 279 ASN A 303 1 ? 25 
HELX_P HELX_P9  AA9 THR A 326 ? ARG A 336 ? THR A 326 ARG A 336 1 ? 11 
HELX_P HELX_P10 AB1 HIS A 346 ? GLY A 361 ? HIS A 346 GLY A 361 1 ? 16 
HELX_P HELX_P11 AB2 VAL A 453 ? ASP A 455 ? VAL A 453 ASP A 455 5 ? 3  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A THR 68 O   ? ? ? 1_555 B CA . CA ? ? A THR 68 A CA 501 1_555 ? ? ? ? ? ? ? 2.190 ? ? 
metalc2 metalc ? ? A ASP 71 OD1 ? ? ? 1_555 B CA . CA ? ? A ASP 71 A CA 501 1_555 ? ? ? ? ? ? ? 2.545 ? ? 
metalc3 metalc ? ? A ARG 73 O   ? ? ? 1_555 B CA . CA ? ? A ARG 73 A CA 501 1_555 ? ? ? ? ? ? ? 2.468 ? ? 
metalc4 metalc ? ? A GLU 89 OE1 ? ? ? 1_555 B CA . CA ? ? A GLU 89 A CA 501 1_555 ? ? ? ? ? ? ? 2.389 ? ? 
metalc5 metalc ? ? A GLU 89 OE2 ? ? ? 1_555 B CA . CA ? ? A GLU 89 A CA 501 1_555 ? ? ? ? ? ? ? 2.243 ? ? 
metalc6 metalc ? ? A GLU 92 OE1 ? ? ? 1_555 B CA . CA ? ? A GLU 92 A CA 501 1_555 ? ? ? ? ? ? ? 2.589 ? ? 
metalc7 metalc ? ? A GLU 92 OE2 ? ? ? 1_555 B CA . CA ? ? A GLU 92 A CA 501 1_555 ? ? ? ? ? ? ? 2.579 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  O   ? A THR 68 ? A THR 68 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 OD1 ? A ASP 71 ? A ASP 71 ? 1_555 70.9  ? 
2  O   ? A THR 68 ? A THR 68 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? A ARG 73 ? A ARG 73 ? 1_555 159.9 ? 
3  OD1 ? A ASP 71 ? A ASP 71 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 O   ? A ARG 73 ? A ARG 73 ? 1_555 97.9  ? 
4  O   ? A THR 68 ? A THR 68 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 OE1 ? A GLU 89 ? A GLU 89 ? 1_555 76.6  ? 
5  OD1 ? A ASP 71 ? A ASP 71 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 OE1 ? A GLU 89 ? A GLU 89 ? 1_555 136.1 ? 
6  O   ? A ARG 73 ? A ARG 73 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 OE1 ? A GLU 89 ? A GLU 89 ? 1_555 103.1 ? 
7  O   ? A THR 68 ? A THR 68 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 OE2 ? A GLU 89 ? A GLU 89 ? 1_555 118.3 ? 
8  OD1 ? A ASP 71 ? A ASP 71 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 OE2 ? A GLU 89 ? A GLU 89 ? 1_555 167.3 ? 
9  O   ? A ARG 73 ? A ARG 73 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 OE2 ? A GLU 89 ? A GLU 89 ? 1_555 75.7  ? 
10 OE1 ? A GLU 89 ? A GLU 89 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 OE2 ? A GLU 89 ? A GLU 89 ? 1_555 56.5  ? 
11 O   ? A THR 68 ? A THR 68 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 OE1 ? A GLU 92 ? A GLU 92 ? 1_555 122.4 ? 
12 OD1 ? A ASP 71 ? A ASP 71 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 OE1 ? A GLU 92 ? A GLU 92 ? 1_555 66.6  ? 
13 O   ? A ARG 73 ? A ARG 73 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 OE1 ? A GLU 92 ? A GLU 92 ? 1_555 63.9  ? 
14 OE1 ? A GLU 89 ? A GLU 89 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 OE1 ? A GLU 92 ? A GLU 92 ? 1_555 157.0 ? 
15 OE2 ? A GLU 89 ? A GLU 89 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 OE1 ? A GLU 92 ? A GLU 92 ? 1_555 100.7 ? 
16 O   ? A THR 68 ? A THR 68 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 OE2 ? A GLU 92 ? A GLU 92 ? 1_555 97.0  ? 
17 OD1 ? A ASP 71 ? A ASP 71 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 OE2 ? A GLU 92 ? A GLU 92 ? 1_555 93.0  ? 
18 O   ? A ARG 73 ? A ARG 73 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 OE2 ? A GLU 92 ? A GLU 92 ? 1_555 100.3 ? 
19 OE1 ? A GLU 89 ? A GLU 89 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 OE2 ? A GLU 92 ? A GLU 92 ? 1_555 120.0 ? 
20 OE2 ? A GLU 89 ? A GLU 89 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 OE2 ? A GLU 92 ? A GLU 92 ? 1_555 77.7  ? 
21 OE1 ? A GLU 92 ? A GLU 92 ? 1_555 CA ? B CA . ? A CA 501 ? 1_555 OE2 ? A GLU 92 ? A GLU 92 ? 1_555 50.1  ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 4 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
AA5 ? 4 ? 
AA6 ? 4 ? 
AA7 ? 7 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA7 1 2 ? parallel      
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA7 4 5 ? parallel      
AA7 5 6 ? anti-parallel 
AA7 6 7 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 TRP A 51  ? VAL A 52  ? TRP A 51  VAL A 52  
AA1 2 VAL A 410 ? ARG A 414 ? VAL A 410 ARG A 414 
AA1 3 ILE A 438 ? ILE A 451 ? ILE A 438 ILE A 451 
AA1 4 SER A 258 ? HIS A 267 ? SER A 258 HIS A 267 
AA2 1 TRP A 51  ? VAL A 52  ? TRP A 51  VAL A 52  
AA2 2 VAL A 410 ? ARG A 414 ? VAL A 410 ARG A 414 
AA2 3 ILE A 438 ? ILE A 451 ? ILE A 438 ILE A 451 
AA2 4 LEU A 426 ? ILE A 433 ? LEU A 426 ILE A 433 
AA3 1 ALA A 58  ? VAL A 61  ? ALA A 58  VAL A 61  
AA3 2 ARG A 253 ? GLU A 256 ? ARG A 253 GLU A 256 
AA4 1 PHE A 76  ? ASP A 79  ? PHE A 76  ASP A 79  
AA4 2 THR A 82  ? VAL A 85  ? THR A 82  VAL A 85  
AA5 1 VAL A 113 ? PHE A 117 ? VAL A 113 PHE A 117 
AA5 2 GLY A 186 ? SER A 192 ? GLY A 186 SER A 192 
AA5 3 GLU A 132 ? ILE A 136 ? GLU A 132 ILE A 136 
AA5 4 ARG A 163 ? PHE A 164 ? ARG A 163 PHE A 164 
AA6 1 THR A 122 ? VAL A 124 ? THR A 122 VAL A 124 
AA6 2 THR A 179 ? ALA A 182 ? THR A 179 ALA A 182 
AA6 3 ILE A 141 ? ALA A 144 ? ILE A 141 ALA A 144 
AA6 4 THR A 154 ? LEU A 158 ? THR A 154 LEU A 158 
AA7 1 ARG A 317 ? GLN A 319 ? ARG A 317 GLN A 319 
AA7 2 VAL A 457 ? GLN A 464 ? VAL A 457 GLN A 464 
AA7 3 THR A 395 ? LEU A 401 ? THR A 395 LEU A 401 
AA7 4 PHE A 342 ? ALA A 345 ? PHE A 342 ALA A 345 
AA7 5 VAL A 380 ? PRO A 384 ? VAL A 380 PRO A 384 
AA7 6 GLN A 372 ? TRP A 377 ? GLN A 372 TRP A 377 
AA7 7 HIS A 366 ? LEU A 369 ? HIS A 366 LEU A 369 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N VAL A 52  ? N VAL A 52  O ARG A 414 ? O ARG A 414 
AA1 2 3 N ILE A 411 ? N ILE A 411 O ALA A 450 ? O ALA A 450 
AA1 3 4 O THR A 445 ? O THR A 445 N ALA A 260 ? N ALA A 260 
AA2 1 2 N VAL A 52  ? N VAL A 52  O ARG A 414 ? O ARG A 414 
AA2 2 3 N ILE A 411 ? N ILE A 411 O ALA A 450 ? O ALA A 450 
AA2 3 4 O SER A 440 ? O SER A 440 N MET A 431 ? N MET A 431 
AA3 1 2 N VAL A 61  ? N VAL A 61  O ARG A 253 ? O ARG A 253 
AA4 1 2 N VAL A 77  ? N VAL A 77  O ARG A 84  ? O ARG A 84  
AA5 1 2 N ARG A 115 ? N ARG A 115 O LEU A 188 ? O LEU A 188 
AA5 2 3 O LEU A 189 ? O LEU A 189 N LEU A 135 ? N LEU A 135 
AA5 3 4 N HIS A 134 ? N HIS A 134 O PHE A 164 ? O PHE A 164 
AA6 1 2 N LEU A 123 ? N LEU A 123 O ALA A 180 ? O ALA A 180 
AA6 2 3 O THR A 181 ? O THR A 181 N GLY A 142 ? N GLY A 142 
AA6 3 4 N ILE A 141 ? N ILE A 141 O LEU A 158 ? O LEU A 158 
AA7 1 2 N ILE A 318 ? N ILE A 318 O VAL A 459 ? O VAL A 459 
AA7 2 3 O VAL A 463 ? O VAL A 463 N SER A 396 ? N SER A 396 
AA7 3 4 O LEU A 401 ? O LEU A 401 N PHE A 342 ? N PHE A 342 
AA7 4 5 N PHE A 343 ? N PHE A 343 O LEU A 383 ? O LEU A 383 
AA7 5 6 O ILE A 382 ? O ILE A 382 N PRO A 375 ? N PRO A 375 
AA7 6 7 O GLN A 372 ? O GLN A 372 N LEU A 369 ? N LEU A 369 
# 
_pdbx_entry_details.entry_id                   9BHU 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 LEU A 95  ? ? -55.89  -6.93   
2 1 ASP A 98  ? ? 71.45   -3.80   
3 1 ASP A 156 ? ? -163.48 -168.46 
4 1 GLN A 408 ? ? -59.11  109.51  
5 1 MET A 431 ? ? -93.29  -60.54  
6 1 ASP A 455 ? ? -89.79  44.50   
# 
_pdbx_point_symmetry.entry_id             9BHU 
_pdbx_point_symmetry.Schoenflies_symbol   I 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9BHU 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   'cross-correlation coefficient' 
_em_3d_fitting.details           
;An AlphaFold-generated model was fit into the map using ChimeraX v1.5. The model was then refined iteratively by alternating rounds of manual refinement in Coot v8.9.1 and real-space refinements using PHENIX v1.20.1-4487.
;
_em_3d_fitting.overall_b_value   127.9 
_em_3d_fitting.ref_space         REAL 
_em_3d_fitting.ref_protocol      'FLEXIBLE FIT' 
# 
_em_3d_fitting_list.id                            1 
_em_3d_fitting_list.3d_fitting_id                 1 
_em_3d_fitting_list.pdb_entry_id                  . 
_em_3d_fitting_list.pdb_chain_id                  . 
_em_3d_fitting_list.pdb_chain_residue_range       . 
_em_3d_fitting_list.details                       ? 
_em_3d_fitting_list.chain_id                      ? 
_em_3d_fitting_list.chain_residue_range           ? 
_em_3d_fitting_list.source_name                   AlphaFold 
_em_3d_fitting_list.type                          'in silico model' 
_em_3d_fitting_list.accession_code                Q54255 
_em_3d_fitting_list.initial_refinement_model_id   1 
# 
_em_3d_reconstruction.entry_id                    9BHU 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     
;Homogeneous refinement with I symmetry imposed, per-particle defocus optimization, per-group CTF parameterization, spherical aberration fit enabled, tetrafoil fit enabled, Ewald sphere correction with negative curvature, and minimize over per-particle scale enabled.
;
_em_3d_reconstruction.resolution                  2.71 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               135027 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       '150 mM NaCl, 20 mM Tris pH 7.5' 
_em_buffer.pH            7.5 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Streptomyces griseus Family 2B encapsulin shell' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_image_scans.entry_id                9BHU 
_em_image_scans.id                      1 
_em_image_scans.number_digital_images   ? 
_em_image_scans.details                 ? 
_em_image_scans.scanner_model           ? 
_em_image_scans.sampling_size           ? 
_em_image_scans.od_range                ? 
_em_image_scans.quant_bit_size          ? 
_em_image_scans.citation_id             ? 
_em_image_scans.dimension_height        3838 
_em_image_scans.dimension_width         3710 
_em_image_scans.frames_per_image        25 
_em_image_scans.image_recording_id      1 
_em_image_scans.used_frames_per_image   ? 
# 
_em_imaging.entry_id                        9BHU 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS GLACIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            200 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1000 
_em_imaging.nominal_defocus_max             1800 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           45000 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    COPPER 
_em_sample_support.grid_mesh_size   200 
_em_sample_support.grid_type        'Quantifoil R1.2/1.3' 
_em_sample_support.details          '60 seconds at 5 mA under vacuum' 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_vitrification.entry_id              9BHU 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   295 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               
;Blot force: 20
Blot time: 4 seconds
;
# 
_em_experiment.entry_id                9BHU 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
_em_single_particle_entity.entry_id              9BHU 
_em_single_particle_entity.id                    1 
_em_single_particle_entity.image_processing_id   1 
_em_single_particle_entity.point_symmetry        I 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A THR 2   ? A THR 2   
3  1 Y 1 A VAL 3   ? A VAL 3   
4  1 Y 1 A ASP 4   ? A ASP 4   
5  1 Y 1 A SER 5   ? A SER 5   
6  1 Y 1 A THR 6   ? A THR 6   
7  1 Y 1 A SER 7   ? A SER 7   
8  1 Y 1 A GLU 8   ? A GLU 8   
9  1 Y 1 A ALA 9   ? A ALA 9   
10 1 Y 1 A ARG 10  ? A ARG 10  
11 1 Y 1 A LEU 11  ? A LEU 11  
12 1 Y 1 A GLU 12  ? A GLU 12  
13 1 Y 1 A VAL 13  ? A VAL 13  
14 1 Y 1 A PRO 14  ? A PRO 14  
15 1 Y 1 A ARG 15  ? A ARG 15  
16 1 Y 1 A GLN 16  ? A GLN 16  
17 1 Y 1 A SER 17  ? A SER 17  
18 1 Y 1 A SER 18  ? A SER 18  
19 1 Y 1 A LEU 19  ? A LEU 19  
20 1 Y 1 A GLY 20  ? A GLY 20  
21 1 Y 1 A THR 21  ? A THR 21  
22 1 Y 1 A ALA 22  ? A ALA 22  
23 1 Y 1 A ALA 23  ? A ALA 23  
24 1 Y 1 A ALA 24  ? A ALA 24  
25 1 Y 1 A ARG 25  ? A ARG 25  
26 1 Y 1 A ASN 26  ? A ASN 26  
27 1 Y 1 A LEU 27  ? A LEU 27  
28 1 Y 1 A ALA 28  ? A ALA 28  
29 1 Y 1 A SER 29  ? A SER 29  
30 1 Y 1 A THR 30  ? A THR 30  
31 1 Y 1 A THR 31  ? A THR 31  
32 1 Y 1 A LYS 32  ? A LYS 32  
33 1 Y 1 A SER 33  ? A SER 33  
34 1 Y 1 A ALA 34  ? A ALA 34  
35 1 Y 1 A PRO 35  ? A PRO 35  
36 1 Y 1 A GLN 36  ? A GLN 36  
37 1 Y 1 A MET 37  ? A MET 37  
38 1 Y 1 A GLN 38  ? A GLN 38  
39 1 Y 1 A GLU 39  ? A GLU 39  
40 1 Y 1 A GLY 147 ? A GLY 147 
41 1 Y 1 A SER 148 ? A SER 148 
42 1 Y 1 A TYR 149 ? A TYR 149 
43 1 Y 1 A GLY 150 ? A GLY 150 
44 1 Y 1 A ASP 151 ? A ASP 151 
45 1 Y 1 A GLU 152 ? A GLU 152 
46 1 Y 1 A ARG 216 ? A ARG 216 
47 1 Y 1 A SER 217 ? A SER 217 
48 1 Y 1 A GLU 218 ? A GLU 218 
49 1 Y 1 A GLN 219 ? A GLN 219 
50 1 Y 1 A ARG 220 ? A ARG 220 
51 1 Y 1 A GLN 221 ? A GLN 221 
52 1 Y 1 A ASN 222 ? A ASN 222 
53 1 Y 1 A HIS 223 ? A HIS 223 
54 1 Y 1 A ARG 224 ? A ARG 224 
55 1 Y 1 A GLY 225 ? A GLY 225 
56 1 Y 1 A GLU 226 ? A GLU 226 
57 1 Y 1 A ALA 227 ? A ALA 227 
58 1 Y 1 A GLU 228 ? A GLU 228 
59 1 Y 1 A ILE 229 ? A ILE 229 
60 1 Y 1 A ALA 230 ? A ALA 230 
61 1 Y 1 A MET 231 ? A MET 231 
62 1 Y 1 A SER 232 ? A SER 232 
63 1 Y 1 A ALA 233 ? A ALA 233 
64 1 Y 1 A GLY 234 ? A GLY 234 
65 1 Y 1 A HIS 235 ? A HIS 235 
66 1 Y 1 A VAL 236 ? A VAL 236 
67 1 Y 1 A GLY 237 ? A GLY 237 
68 1 Y 1 A GLU 238 ? A GLU 238 
69 1 Y 1 A HIS 239 ? A HIS 239 
70 1 Y 1 A GLU 240 ? A GLU 240 
71 1 Y 1 A LEU 241 ? A LEU 241 
72 1 Y 1 A PRO 242 ? A PRO 242 
73 1 Y 1 A GLY 243 ? A GLY 243 
74 1 Y 1 A ALA 244 ? A ALA 244 
75 1 Y 1 A PHE 245 ? A PHE 245 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CA  CA   CA N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
GLN N    N  N N 89  
GLN CA   C  N S 90  
GLN C    C  N N 91  
GLN O    O  N N 92  
GLN CB   C  N N 93  
GLN CG   C  N N 94  
GLN CD   C  N N 95  
GLN OE1  O  N N 96  
GLN NE2  N  N N 97  
GLN OXT  O  N N 98  
GLN H    H  N N 99  
GLN H2   H  N N 100 
GLN HA   H  N N 101 
GLN HB2  H  N N 102 
GLN HB3  H  N N 103 
GLN HG2  H  N N 104 
GLN HG3  H  N N 105 
GLN HE21 H  N N 106 
GLN HE22 H  N N 107 
GLN HXT  H  N N 108 
GLU N    N  N N 109 
GLU CA   C  N S 110 
GLU C    C  N N 111 
GLU O    O  N N 112 
GLU CB   C  N N 113 
GLU CG   C  N N 114 
GLU CD   C  N N 115 
GLU OE1  O  N N 116 
GLU OE2  O  N N 117 
GLU OXT  O  N N 118 
GLU H    H  N N 119 
GLU H2   H  N N 120 
GLU HA   H  N N 121 
GLU HB2  H  N N 122 
GLU HB3  H  N N 123 
GLU HG2  H  N N 124 
GLU HG3  H  N N 125 
GLU HE2  H  N N 126 
GLU HXT  H  N N 127 
GLY N    N  N N 128 
GLY CA   C  N N 129 
GLY C    C  N N 130 
GLY O    O  N N 131 
GLY OXT  O  N N 132 
GLY H    H  N N 133 
GLY H2   H  N N 134 
GLY HA2  H  N N 135 
GLY HA3  H  N N 136 
GLY HXT  H  N N 137 
HIS N    N  N N 138 
HIS CA   C  N S 139 
HIS C    C  N N 140 
HIS O    O  N N 141 
HIS CB   C  N N 142 
HIS CG   C  Y N 143 
HIS ND1  N  Y N 144 
HIS CD2  C  Y N 145 
HIS CE1  C  Y N 146 
HIS NE2  N  Y N 147 
HIS OXT  O  N N 148 
HIS H    H  N N 149 
HIS H2   H  N N 150 
HIS HA   H  N N 151 
HIS HB2  H  N N 152 
HIS HB3  H  N N 153 
HIS HD1  H  N N 154 
HIS HD2  H  N N 155 
HIS HE1  H  N N 156 
HIS HE2  H  N N 157 
HIS HXT  H  N N 158 
ILE N    N  N N 159 
ILE CA   C  N S 160 
ILE C    C  N N 161 
ILE O    O  N N 162 
ILE CB   C  N S 163 
ILE CG1  C  N N 164 
ILE CG2  C  N N 165 
ILE CD1  C  N N 166 
ILE OXT  O  N N 167 
ILE H    H  N N 168 
ILE H2   H  N N 169 
ILE HA   H  N N 170 
ILE HB   H  N N 171 
ILE HG12 H  N N 172 
ILE HG13 H  N N 173 
ILE HG21 H  N N 174 
ILE HG22 H  N N 175 
ILE HG23 H  N N 176 
ILE HD11 H  N N 177 
ILE HD12 H  N N 178 
ILE HD13 H  N N 179 
ILE HXT  H  N N 180 
LEU N    N  N N 181 
LEU CA   C  N S 182 
LEU C    C  N N 183 
LEU O    O  N N 184 
LEU CB   C  N N 185 
LEU CG   C  N N 186 
LEU CD1  C  N N 187 
LEU CD2  C  N N 188 
LEU OXT  O  N N 189 
LEU H    H  N N 190 
LEU H2   H  N N 191 
LEU HA   H  N N 192 
LEU HB2  H  N N 193 
LEU HB3  H  N N 194 
LEU HG   H  N N 195 
LEU HD11 H  N N 196 
LEU HD12 H  N N 197 
LEU HD13 H  N N 198 
LEU HD21 H  N N 199 
LEU HD22 H  N N 200 
LEU HD23 H  N N 201 
LEU HXT  H  N N 202 
LYS N    N  N N 203 
LYS CA   C  N S 204 
LYS C    C  N N 205 
LYS O    O  N N 206 
LYS CB   C  N N 207 
LYS CG   C  N N 208 
LYS CD   C  N N 209 
LYS CE   C  N N 210 
LYS NZ   N  N N 211 
LYS OXT  O  N N 212 
LYS H    H  N N 213 
LYS H2   H  N N 214 
LYS HA   H  N N 215 
LYS HB2  H  N N 216 
LYS HB3  H  N N 217 
LYS HG2  H  N N 218 
LYS HG3  H  N N 219 
LYS HD2  H  N N 220 
LYS HD3  H  N N 221 
LYS HE2  H  N N 222 
LYS HE3  H  N N 223 
LYS HZ1  H  N N 224 
LYS HZ2  H  N N 225 
LYS HZ3  H  N N 226 
LYS HXT  H  N N 227 
MET N    N  N N 228 
MET CA   C  N S 229 
MET C    C  N N 230 
MET O    O  N N 231 
MET CB   C  N N 232 
MET CG   C  N N 233 
MET SD   S  N N 234 
MET CE   C  N N 235 
MET OXT  O  N N 236 
MET H    H  N N 237 
MET H2   H  N N 238 
MET HA   H  N N 239 
MET HB2  H  N N 240 
MET HB3  H  N N 241 
MET HG2  H  N N 242 
MET HG3  H  N N 243 
MET HE1  H  N N 244 
MET HE2  H  N N 245 
MET HE3  H  N N 246 
MET HXT  H  N N 247 
PHE N    N  N N 248 
PHE CA   C  N S 249 
PHE C    C  N N 250 
PHE O    O  N N 251 
PHE CB   C  N N 252 
PHE CG   C  Y N 253 
PHE CD1  C  Y N 254 
PHE CD2  C  Y N 255 
PHE CE1  C  Y N 256 
PHE CE2  C  Y N 257 
PHE CZ   C  Y N 258 
PHE OXT  O  N N 259 
PHE H    H  N N 260 
PHE H2   H  N N 261 
PHE HA   H  N N 262 
PHE HB2  H  N N 263 
PHE HB3  H  N N 264 
PHE HD1  H  N N 265 
PHE HD2  H  N N 266 
PHE HE1  H  N N 267 
PHE HE2  H  N N 268 
PHE HZ   H  N N 269 
PHE HXT  H  N N 270 
PRO N    N  N N 271 
PRO CA   C  N S 272 
PRO C    C  N N 273 
PRO O    O  N N 274 
PRO CB   C  N N 275 
PRO CG   C  N N 276 
PRO CD   C  N N 277 
PRO OXT  O  N N 278 
PRO H    H  N N 279 
PRO HA   H  N N 280 
PRO HB2  H  N N 281 
PRO HB3  H  N N 282 
PRO HG2  H  N N 283 
PRO HG3  H  N N 284 
PRO HD2  H  N N 285 
PRO HD3  H  N N 286 
PRO HXT  H  N N 287 
SER N    N  N N 288 
SER CA   C  N S 289 
SER C    C  N N 290 
SER O    O  N N 291 
SER CB   C  N N 292 
SER OG   O  N N 293 
SER OXT  O  N N 294 
SER H    H  N N 295 
SER H2   H  N N 296 
SER HA   H  N N 297 
SER HB2  H  N N 298 
SER HB3  H  N N 299 
SER HG   H  N N 300 
SER HXT  H  N N 301 
THR N    N  N N 302 
THR CA   C  N S 303 
THR C    C  N N 304 
THR O    O  N N 305 
THR CB   C  N R 306 
THR OG1  O  N N 307 
THR CG2  C  N N 308 
THR OXT  O  N N 309 
THR H    H  N N 310 
THR H2   H  N N 311 
THR HA   H  N N 312 
THR HB   H  N N 313 
THR HG1  H  N N 314 
THR HG21 H  N N 315 
THR HG22 H  N N 316 
THR HG23 H  N N 317 
THR HXT  H  N N 318 
TRP N    N  N N 319 
TRP CA   C  N S 320 
TRP C    C  N N 321 
TRP O    O  N N 322 
TRP CB   C  N N 323 
TRP CG   C  Y N 324 
TRP CD1  C  Y N 325 
TRP CD2  C  Y N 326 
TRP NE1  N  Y N 327 
TRP CE2  C  Y N 328 
TRP CE3  C  Y N 329 
TRP CZ2  C  Y N 330 
TRP CZ3  C  Y N 331 
TRP CH2  C  Y N 332 
TRP OXT  O  N N 333 
TRP H    H  N N 334 
TRP H2   H  N N 335 
TRP HA   H  N N 336 
TRP HB2  H  N N 337 
TRP HB3  H  N N 338 
TRP HD1  H  N N 339 
TRP HE1  H  N N 340 
TRP HE3  H  N N 341 
TRP HZ2  H  N N 342 
TRP HZ3  H  N N 343 
TRP HH2  H  N N 344 
TRP HXT  H  N N 345 
TYR N    N  N N 346 
TYR CA   C  N S 347 
TYR C    C  N N 348 
TYR O    O  N N 349 
TYR CB   C  N N 350 
TYR CG   C  Y N 351 
TYR CD1  C  Y N 352 
TYR CD2  C  Y N 353 
TYR CE1  C  Y N 354 
TYR CE2  C  Y N 355 
TYR CZ   C  Y N 356 
TYR OH   O  N N 357 
TYR OXT  O  N N 358 
TYR H    H  N N 359 
TYR H2   H  N N 360 
TYR HA   H  N N 361 
TYR HB2  H  N N 362 
TYR HB3  H  N N 363 
TYR HD1  H  N N 364 
TYR HD2  H  N N 365 
TYR HE1  H  N N 366 
TYR HE2  H  N N 367 
TYR HH   H  N N 368 
TYR HXT  H  N N 369 
VAL N    N  N N 370 
VAL CA   C  N S 371 
VAL C    C  N N 372 
VAL O    O  N N 373 
VAL CB   C  N N 374 
VAL CG1  C  N N 375 
VAL CG2  C  N N 376 
VAL OXT  O  N N 377 
VAL H    H  N N 378 
VAL H2   H  N N 379 
VAL HA   H  N N 380 
VAL HB   H  N N 381 
VAL HG11 H  N N 382 
VAL HG12 H  N N 383 
VAL HG13 H  N N 384 
VAL HG21 H  N N 385 
VAL HG22 H  N N 386 
VAL HG23 H  N N 387 
VAL HXT  H  N N 388 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-04-22 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           9BHU 
_em_admin.last_update        2024-11-27 
_em_admin.map_release_date   2024-11-27 
_em_admin.title              'Streptomyces griseus Family 2B encapsulin shell' 
# 
loop_
_em_buffer_component.buffer_id 
_em_buffer_component.concentration 
_em_buffer_component.concentration_units 
_em_buffer_component.formula 
_em_buffer_component.id 
_em_buffer_component.name 
1 150 mM NaCl     1 'sodium chloride' 
1 20  mM C4H11NO3 2 tris              
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                ? 
_em_entity_assembly_molwt.value                ? 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          67263 
_em_entity_assembly_naturalsource.organism             'Streptomyces griseus subsp. griseus' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          469008 
_em_entity_assembly_recombinant.organism             'Escherichia coli BL21(DE3)' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               5 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         43.22 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       COUNTING 
_em_image_recording.film_or_detector_model              'GATAN K2 SUMMIT (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    1 
_em_image_recording.num_real_images                     ? 
# 
_em_particle_selection.details                  ? 
_em_particle_selection.id                       1 
_em_particle_selection.image_processing_id      1 
_em_particle_selection.method                   ? 
_em_particle_selection.num_particles_selected   159394 
_em_particle_selection.reference_model          ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            'Template Picker'        1  1 ? ? cryoSPARC       4.4.0+231114 
'IMAGE ACQUISITION'             ?                        2  ? ? 1 Leginon         ?            
MASKING                         ?                        3  ? ? ? ?               ?            
'CTF CORRECTION'                'Patch CTF Estimation'   4  1 ? ? cryoSPARC       4.4.0+231114 
'LAYERLINE INDEXING'            ?                        5  ? ? ? ?               ?            
'DIFFRACTION INDEXING'          ?                        6  ? ? ? ?               ?            
'MODEL FITTING'                 ?                        7  ? 1 ? 'UCSF ChimeraX' 1.5          
OTHER                           ?                        8  ? ? ? ?               ?            
'MODEL REFINEMENT'              ?                        9  ? 1 ? Coot            8.9.1        
'MODEL REFINEMENT'              ?                        10 ? 1 ? PHENIX          1.20.1-4487  
'INITIAL EULER ASSIGNMENT'      ?                        11 1 ? ? cryoSPARC       4.4.0+231114 
'FINAL EULER ASSIGNMENT'        ?                        12 1 ? ? cryoSPARC       4.4.0+231114 
CLASSIFICATION                  ?                        13 1 ? ? ?               ?            
RECONSTRUCTION                  'Homogeneous Refinement' 14 1 ? ? cryoSPARC       4.4.0+231114 
'VOLUME SELECTION'              ?                        15 1 1 1 ?               ?            
'SERIES ALIGNMENT'              ?                        16 1 1 1 ?               ?            
'MOLECULAR REPLACEMENT'         ?                        17 1 1 1 ?               ?            
'LATTICE DISTORTION CORRECTION' ?                        18 1 1 1 ?               ?            
'SYMMETRY DETERMINATION'        ?                        19 1 1 1 ?               ?            
'CRYSTALLOGRAPHY MERGING'       ?                        20 1 1 1 ?               ?            
# 
_em_specimen.concentration           2.5 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           R35GM133325 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   Q54255 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9BHU 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
CA 
N  
O  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ILE A 1 40  ? 174.652 229.873 293.546 1.00 53.11 ? 40  ILE A N   1 
ATOM   2    C  CA  . ILE A 1 40  ? 174.565 230.712 292.359 1.00 53.11 ? 40  ILE A CA  1 
ATOM   3    C  C   . ILE A 1 40  ? 175.722 231.710 292.338 1.00 53.11 ? 40  ILE A C   1 
ATOM   4    O  O   . ILE A 1 40  ? 175.931 232.416 291.350 1.00 53.11 ? 40  ILE A O   1 
ATOM   5    C  CB  . ILE A 1 40  ? 173.207 231.432 292.289 1.00 53.11 ? 40  ILE A CB  1 
ATOM   6    C  CG1 . ILE A 1 40  ? 172.841 231.746 290.836 1.00 53.11 ? 40  ILE A CG1 1 
ATOM   7    C  CG2 . ILE A 1 40  ? 173.223 232.697 293.133 1.00 53.11 ? 40  ILE A CG2 1 
ATOM   8    C  CD1 . ILE A 1 40  ? 172.589 230.511 289.989 1.00 53.11 ? 40  ILE A CD1 1 
ATOM   9    N  N   . THR A 1 41  ? 176.464 231.769 293.442 1.00 46.99 ? 41  THR A N   1 
ATOM   10   C  CA  . THR A 1 41  ? 177.600 232.668 293.566 1.00 46.99 ? 41  THR A CA  1 
ATOM   11   C  C   . THR A 1 41  ? 178.834 232.080 292.883 1.00 46.99 ? 41  THR A C   1 
ATOM   12   O  O   . THR A 1 41  ? 178.859 230.921 292.469 1.00 46.99 ? 41  THR A O   1 
ATOM   13   C  CB  . THR A 1 41  ? 177.896 232.953 295.035 1.00 46.99 ? 41  THR A CB  1 
ATOM   14   O  OG1 . THR A 1 41  ? 178.394 231.766 295.658 1.00 46.99 ? 41  THR A OG1 1 
ATOM   15   C  CG2 . THR A 1 41  ? 176.629 233.391 295.750 1.00 46.99 ? 41  THR A CG2 1 
ATOM   16   N  N   . SER A 1 42  ? 179.855 232.918 292.729 1.00 39.16 ? 42  SER A N   1 
ATOM   17   C  CA  . SER A 1 42  ? 181.102 232.480 292.119 1.00 39.16 ? 42  SER A CA  1 
ATOM   18   C  C   . SER A 1 42  ? 181.869 231.579 293.071 1.00 39.16 ? 42  SER A C   1 
ATOM   19   O  O   . SER A 1 42  ? 181.998 231.870 294.262 1.00 39.16 ? 42  SER A O   1 
ATOM   20   C  CB  . SER A 1 42  ? 181.960 233.680 291.740 1.00 39.16 ? 42  SER A CB  1 
ATOM   21   O  OG  . SER A 1 42  ? 182.301 234.423 292.894 1.00 39.16 ? 42  SER A OG  1 
ATOM   22   N  N   . ARG A 1 43  ? 182.380 230.483 292.541 1.00 34.24 ? 43  ARG A N   1 
ATOM   23   C  CA  . ARG A 1 43  ? 183.144 229.520 293.318 1.00 34.24 ? 43  ARG A CA  1 
ATOM   24   C  C   . ARG A 1 43  ? 184.574 229.578 292.808 1.00 34.24 ? 43  ARG A C   1 
ATOM   25   O  O   . ARG A 1 43  ? 184.960 228.831 291.912 1.00 34.24 ? 43  ARG A O   1 
ATOM   26   C  CB  . ARG A 1 43  ? 182.542 228.148 293.201 1.00 34.24 ? 43  ARG A CB  1 
ATOM   27   C  CG  . ARG A 1 43  ? 181.132 228.077 293.741 1.00 34.24 ? 43  ARG A CG  1 
ATOM   28   C  CD  . ARG A 1 43  ? 180.516 226.772 293.387 1.00 34.24 ? 43  ARG A CD  1 
ATOM   29   N  NE  . ARG A 1 43  ? 180.224 226.640 291.969 1.00 34.24 ? 43  ARG A NE  1 
ATOM   30   C  CZ  . ARG A 1 43  ? 179.042 226.891 291.430 1.00 34.24 ? 43  ARG A CZ  1 
ATOM   31   N  NH1 . ARG A 1 43  ? 178.023 227.301 292.163 1.00 34.24 ? 43  ARG A NH1 1 
ATOM   32   N  NH2 . ARG A 1 43  ? 178.874 226.707 290.126 1.00 34.24 ? 43  ARG A NH2 1 
ATOM   33   N  N   . TRP A 1 44  ? 185.354 230.492 293.377 1.00 31.83 ? 44  TRP A N   1 
ATOM   34   C  CA  . TRP A 1 44  ? 186.706 230.715 292.887 1.00 31.83 ? 44  TRP A CA  1 
ATOM   35   C  C   . TRP A 1 44  ? 187.628 229.563 293.242 1.00 31.83 ? 44  TRP A C   1 
ATOM   36   O  O   . TRP A 1 44  ? 188.500 229.200 292.452 1.00 31.83 ? 44  TRP A O   1 
ATOM   37   C  CB  . TRP A 1 44  ? 187.246 232.023 293.452 1.00 31.83 ? 44  TRP A CB  1 
ATOM   38   C  CG  . TRP A 1 44  ? 186.802 233.216 292.687 1.00 31.83 ? 44  TRP A CG  1 
ATOM   39   C  CD1 . TRP A 1 44  ? 185.925 234.162 293.093 1.00 31.83 ? 44  TRP A CD1 1 
ATOM   40   C  CD2 . TRP A 1 44  ? 187.218 233.591 291.376 1.00 31.83 ? 44  TRP A CD2 1 
ATOM   41   N  NE1 . TRP A 1 44  ? 185.767 235.108 292.119 1.00 31.83 ? 44  TRP A NE1 1 
ATOM   42   C  CE2 . TRP A 1 44  ? 186.553 234.775 291.052 1.00 31.83 ? 44  TRP A CE2 1 
ATOM   43   C  CE3 . TRP A 1 44  ? 188.090 233.036 290.443 1.00 31.83 ? 44  TRP A CE3 1 
ATOM   44   C  CZ2 . TRP A 1 44  ? 186.733 235.414 289.843 1.00 31.83 ? 44  TRP A CZ2 1 
ATOM   45   C  CZ3 . TRP A 1 44  ? 188.265 233.673 289.245 1.00 31.83 ? 44  TRP A CZ3 1 
ATOM   46   C  CH2 . TRP A 1 44  ? 187.592 234.846 288.953 1.00 31.83 ? 44  TRP A CH2 1 
ATOM   47   N  N   . LEU A 1 45  ? 187.476 228.996 294.435 1.00 30.86 ? 45  LEU A N   1 
ATOM   48   C  CA  . LEU A 1 45  ? 188.354 227.902 294.833 1.00 30.86 ? 45  LEU A CA  1 
ATOM   49   C  C   . LEU A 1 45  ? 188.126 226.660 293.985 1.00 30.86 ? 45  LEU A C   1 
ATOM   50   O  O   . LEU A 1 45  ? 189.072 225.926 293.700 1.00 30.86 ? 45  LEU A O   1 
ATOM   51   C  CB  . LEU A 1 45  ? 188.162 227.588 296.309 1.00 30.86 ? 45  LEU A CB  1 
ATOM   52   C  CG  . LEU A 1 45  ? 189.305 226.825 296.961 1.00 30.86 ? 45  LEU A CG  1 
ATOM   53   C  CD1 . LEU A 1 45  ? 190.596 227.585 296.814 1.00 30.86 ? 45  LEU A CD1 1 
ATOM   54   C  CD2 . LEU A 1 45  ? 188.985 226.622 298.401 1.00 30.86 ? 45  LEU A CD2 1 
ATOM   55   N  N   . LEU A 1 46  ? 186.886 226.405 293.579 1.00 31.65 ? 46  LEU A N   1 
ATOM   56   C  CA  . LEU A 1 46  ? 186.607 225.253 292.734 1.00 31.65 ? 46  LEU A CA  1 
ATOM   57   C  C   . LEU A 1 46  ? 187.275 225.389 291.375 1.00 31.65 ? 46  LEU A C   1 
ATOM   58   O  O   . LEU A 1 46  ? 187.766 224.403 290.818 1.00 31.65 ? 46  LEU A O   1 
ATOM   59   C  CB  . LEU A 1 46  ? 185.103 225.062 292.567 1.00 31.65 ? 46  LEU A CB  1 
ATOM   60   C  CG  . LEU A 1 46  ? 184.366 224.251 293.629 1.00 31.65 ? 46  LEU A CG  1 
ATOM   61   C  CD1 . LEU A 1 46  ? 182.968 223.951 293.164 1.00 31.65 ? 46  LEU A CD1 1 
ATOM   62   C  CD2 . LEU A 1 46  ? 185.110 222.978 293.931 1.00 31.65 ? 46  LEU A CD2 1 
ATOM   63   N  N   . ARG A 1 47  ? 187.272 226.591 290.808 1.00 34.14 ? 47  ARG A N   1 
ATOM   64   C  CA  . ARG A 1 47  ? 187.809 226.814 289.473 1.00 34.14 ? 47  ARG A CA  1 
ATOM   65   C  C   . ARG A 1 47  ? 189.281 227.197 289.465 1.00 34.14 ? 47  ARG A C   1 
ATOM   66   O  O   . ARG A 1 47  ? 189.866 227.295 288.385 1.00 34.14 ? 47  ARG A O   1 
ATOM   67   C  CB  . ARG A 1 47  ? 187.008 227.895 288.749 1.00 34.14 ? 47  ARG A CB  1 
ATOM   68   C  CG  . ARG A 1 47  ? 187.391 229.290 289.115 1.00 34.14 ? 47  ARG A CG  1 
ATOM   69   C  CD  . ARG A 1 47  ? 186.652 230.311 288.269 1.00 34.14 ? 47  ARG A CD  1 
ATOM   70   N  NE  . ARG A 1 47  ? 185.605 230.977 289.034 1.00 34.14 ? 47  ARG A NE  1 
ATOM   71   C  CZ  . ARG A 1 47  ? 184.638 231.710 288.505 1.00 34.14 ? 47  ARG A CZ  1 
ATOM   72   N  NH1 . ARG A 1 47  ? 184.552 231.900 287.201 1.00 34.14 ? 47  ARG A NH1 1 
ATOM   73   N  NH2 . ARG A 1 47  ? 183.736 232.269 289.306 1.00 34.14 ? 47  ARG A NH2 1 
ATOM   74   N  N   . MET A 1 48  ? 189.888 227.432 290.627 1.00 34.06 ? 48  MET A N   1 
ATOM   75   C  CA  . MET A 1 48  ? 191.302 227.773 290.699 1.00 34.06 ? 48  MET A CA  1 
ATOM   76   C  C   . MET A 1 48  ? 192.176 226.623 291.163 1.00 34.06 ? 48  MET A C   1 
ATOM   77   O  O   . MET A 1 48  ? 193.339 226.555 290.765 1.00 34.06 ? 48  MET A O   1 
ATOM   78   C  CB  . MET A 1 48  ? 191.527 228.963 291.634 1.00 34.06 ? 48  MET A CB  1 
ATOM   79   C  CG  . MET A 1 48  ? 191.094 230.292 291.057 1.00 34.06 ? 48  MET A CG  1 
ATOM   80   S  SD  . MET A 1 48  ? 192.414 231.107 290.158 1.00 34.06 ? 48  MET A SD  1 
ATOM   81   C  CE  . MET A 1 48  ? 191.732 231.087 288.514 1.00 34.06 ? 48  MET A CE  1 
ATOM   82   N  N   . LEU A 1 49  ? 191.663 225.737 291.998 1.00 31.30 ? 49  LEU A N   1 
ATOM   83   C  CA  . LEU A 1 49  ? 192.451 224.610 292.479 1.00 31.30 ? 49  LEU A CA  1 
ATOM   84   C  C   . LEU A 1 49  ? 192.627 223.575 291.381 1.00 31.30 ? 49  LEU A C   1 
ATOM   85   O  O   . LEU A 1 49  ? 191.629 223.127 290.807 1.00 31.30 ? 49  LEU A O   1 
ATOM   86   C  CB  . LEU A 1 49  ? 191.788 223.960 293.681 1.00 31.30 ? 49  LEU A CB  1 
ATOM   87   C  CG  . LEU A 1 49  ? 192.010 224.611 295.036 1.00 31.30 ? 49  LEU A CG  1 
ATOM   88   C  CD1 . LEU A 1 49  ? 191.411 223.755 296.123 1.00 31.30 ? 49  LEU A CD1 1 
ATOM   89   C  CD2 . LEU A 1 49  ? 193.482 224.819 295.275 1.00 31.30 ? 49  LEU A CD2 1 
ATOM   90   N  N   . PRO A 1 50  ? 193.853 223.195 291.030 1.00 31.84 ? 50  PRO A N   1 
ATOM   91   C  CA  . PRO A 1 50  ? 194.032 222.086 290.094 1.00 31.84 ? 50  PRO A CA  1 
ATOM   92   C  C   . PRO A 1 50  ? 193.521 220.793 290.705 1.00 31.84 ? 50  PRO A C   1 
ATOM   93   O  O   . PRO A 1 50  ? 193.635 220.563 291.908 1.00 31.84 ? 50  PRO A O   1 
ATOM   94   C  CB  . PRO A 1 50  ? 195.545 222.049 289.875 1.00 31.84 ? 50  PRO A CB  1 
ATOM   95   C  CG  . PRO A 1 50  ? 196.103 222.678 291.073 1.00 31.84 ? 50  PRO A CG  1 
ATOM   96   C  CD  . PRO A 1 50  ? 195.139 223.726 291.493 1.00 31.84 ? 50  PRO A CD  1 
ATOM   97   N  N   . TRP A 1 51  ? 192.958 219.940 289.862 1.00 32.04 ? 51  TRP A N   1 
ATOM   98   C  CA  . TRP A 1 51  ? 192.340 218.701 290.304 1.00 32.04 ? 51  TRP A CA  1 
ATOM   99   C  C   . TRP A 1 51  ? 193.177 217.519 289.850 1.00 32.04 ? 51  TRP A C   1 
ATOM   100  O  O   . TRP A 1 51  ? 193.472 217.386 288.660 1.00 32.04 ? 51  TRP A O   1 
ATOM   101  C  CB  . TRP A 1 51  ? 190.916 218.584 289.771 1.00 32.04 ? 51  TRP A CB  1 
ATOM   102  C  CG  . TRP A 1 51  ? 190.039 219.643 290.293 1.00 32.04 ? 51  TRP A CG  1 
ATOM   103  C  CD1 . TRP A 1 51  ? 189.682 220.782 289.661 1.00 32.04 ? 51  TRP A CD1 1 
ATOM   104  C  CD2 . TRP A 1 51  ? 189.401 219.674 291.571 1.00 32.04 ? 51  TRP A CD2 1 
ATOM   105  N  NE1 . TRP A 1 51  ? 188.865 221.530 290.463 1.00 32.04 ? 51  TRP A NE1 1 
ATOM   106  C  CE2 . TRP A 1 51  ? 188.678 220.866 291.644 1.00 32.04 ? 51  TRP A CE2 1 
ATOM   107  C  CE3 . TRP A 1 51  ? 189.373 218.807 292.660 1.00 32.04 ? 51  TRP A CE3 1 
ATOM   108  C  CZ2 . TRP A 1 51  ? 187.939 221.214 292.760 1.00 32.04 ? 51  TRP A CZ2 1 
ATOM   109  C  CZ3 . TRP A 1 51  ? 188.639 219.155 293.763 1.00 32.04 ? 51  TRP A CZ3 1 
ATOM   110  C  CH2 . TRP A 1 51  ? 187.934 220.343 293.808 1.00 32.04 ? 51  TRP A CH2 1 
ATOM   111  N  N   . VAL A 1 52  ? 193.565 216.671 290.793 1.00 35.05 ? 52  VAL A N   1 
ATOM   112  C  CA  . VAL A 1 52  ? 194.356 215.490 290.485 1.00 35.05 ? 52  VAL A CA  1 
ATOM   113  C  C   . VAL A 1 52  ? 193.515 214.255 290.768 1.00 35.05 ? 52  VAL A C   1 
ATOM   114  O  O   . VAL A 1 52  ? 192.654 214.249 291.651 1.00 35.05 ? 52  VAL A O   1 
ATOM   115  C  CB  . VAL A 1 52  ? 195.681 215.456 291.270 1.00 35.05 ? 52  VAL A CB  1 
ATOM   116  C  CG1 . VAL A 1 52  ? 196.478 216.701 290.987 1.00 35.05 ? 52  VAL A CG1 1 
ATOM   117  C  CG2 . VAL A 1 52  ? 195.427 215.322 292.740 1.00 35.05 ? 52  VAL A CG2 1 
ATOM   118  N  N   . GLU A 1 53  ? 193.775 213.199 290.008 1.00 41.27 ? 53  GLU A N   1 
ATOM   119  C  CA  . GLU A 1 53  ? 192.984 211.982 290.087 1.00 41.27 ? 53  GLU A CA  1 
ATOM   120  C  C   . GLU A 1 53  ? 193.587 211.042 291.118 1.00 41.27 ? 53  GLU A C   1 
ATOM   121  O  O   . GLU A 1 53  ? 194.712 210.563 290.949 1.00 41.27 ? 53  GLU A O   1 
ATOM   122  C  CB  . GLU A 1 53  ? 192.934 211.298 288.727 1.00 41.27 ? 53  GLU A CB  1 
ATOM   123  C  CG  . GLU A 1 53  ? 192.422 212.174 287.629 1.00 41.27 ? 53  GLU A CG  1 
ATOM   124  C  CD  . GLU A 1 53  ? 190.969 212.506 287.809 1.00 41.27 ? 53  GLU A CD  1 
ATOM   125  O  OE1 . GLU A 1 53  ? 190.205 211.601 288.200 1.00 41.27 ? 53  GLU A OE1 1 
ATOM   126  O  OE2 . GLU A 1 53  ? 190.591 213.668 287.561 1.00 41.27 ? 53  GLU A OE2 1 
ATOM   127  N  N   . THR A 1 54  ? 192.842 210.782 292.181 1.00 40.08 ? 54  THR A N   1 
ATOM   128  C  CA  . THR A 1 54  ? 193.268 209.820 293.174 1.00 40.08 ? 54  THR A CA  1 
ATOM   129  C  C   . THR A 1 54  ? 192.871 208.413 292.754 1.00 40.08 ? 54  THR A C   1 
ATOM   130  O  O   . THR A 1 54  ? 191.922 208.212 291.994 1.00 40.08 ? 54  THR A O   1 
ATOM   131  C  CB  . THR A 1 54  ? 192.657 210.143 294.530 1.00 40.08 ? 54  THR A CB  1 
ATOM   132  O  OG1 . THR A 1 54  ? 191.351 209.574 294.604 1.00 40.08 ? 54  THR A OG1 1 
ATOM   133  C  CG2 . THR A 1 54  ? 192.545 211.616 294.706 1.00 40.08 ? 54  THR A CG2 1 
ATOM   134  N  N   . LYS A 1 55  ? 193.633 207.436 293.232 1.00 44.07 ? 55  LYS A N   1 
ATOM   135  C  CA  . LYS A 1 55  ? 193.391 206.029 292.956 1.00 44.07 ? 55  LYS A CA  1 
ATOM   136  C  C   . LYS A 1 55  ? 192.875 205.375 294.228 1.00 44.07 ? 55  LYS A C   1 
ATOM   137  O  O   . LYS A 1 55  ? 193.543 205.418 295.264 1.00 44.07 ? 55  LYS A O   1 
ATOM   138  C  CB  . LYS A 1 55  ? 194.662 205.347 292.458 1.00 44.07 ? 55  LYS A CB  1 
ATOM   139  C  CG  . LYS A 1 55  ? 195.155 205.892 291.130 1.00 44.07 ? 55  LYS A CG  1 
ATOM   140  C  CD  . LYS A 1 55  ? 194.210 205.546 290.003 1.00 44.07 ? 55  LYS A CD  1 
ATOM   141  C  CE  . LYS A 1 55  ? 194.765 206.013 288.666 1.00 44.07 ? 55  LYS A CE  1 
ATOM   142  N  NZ  . LYS A 1 55  ? 194.740 207.494 288.515 1.00 44.07 ? 55  LYS A NZ  1 
ATOM   143  N  N   . GLY A 1 56  ? 191.694 204.773 294.148 1.00 41.20 ? 56  GLY A N   1 
ATOM   144  C  CA  . GLY A 1 56  ? 191.079 204.171 295.312 1.00 41.20 ? 56  GLY A CA  1 
ATOM   145  C  C   . GLY A 1 56  ? 190.456 205.147 296.276 1.00 41.20 ? 56  GLY A C   1 
ATOM   146  O  O   . GLY A 1 56  ? 190.167 204.776 297.416 1.00 41.20 ? 56  GLY A O   1 
ATOM   147  N  N   . GLY A 1 57  ? 190.247 206.389 295.854 1.00 38.97 ? 57  GLY A N   1 
ATOM   148  C  CA  . GLY A 1 57  ? 189.701 207.410 296.723 1.00 38.97 ? 57  GLY A CA  1 
ATOM   149  C  C   . GLY A 1 57  ? 190.587 207.796 297.881 1.00 38.97 ? 57  GLY A C   1 
ATOM   150  O  O   . GLY A 1 57  ? 190.078 208.115 298.956 1.00 38.97 ? 57  GLY A O   1 
ATOM   151  N  N   . ALA A 1 58  ? 191.904 207.791 297.688 1.00 39.74 ? 58  ALA A N   1 
ATOM   152  C  CA  . ALA A 1 58  ? 192.840 208.145 298.743 1.00 39.74 ? 58  ALA A CA  1 
ATOM   153  C  C   . ALA A 1 58  ? 194.099 208.720 298.120 1.00 39.74 ? 58  ALA A C   1 
ATOM   154  O  O   . ALA A 1 58  ? 194.456 208.391 296.988 1.00 39.74 ? 58  ALA A O   1 
ATOM   155  C  CB  . ALA A 1 58  ? 193.189 206.952 299.631 1.00 39.74 ? 58  ALA A CB  1 
ATOM   156  N  N   . TYR A 1 59  ? 194.777 209.564 298.890 1.00 39.79 ? 59  TYR A N   1 
ATOM   157  C  CA  . TYR A 1 59  ? 196.008 210.218 298.481 1.00 39.79 ? 59  TYR A CA  1 
ATOM   158  C  C   . TYR A 1 59  ? 196.973 210.211 299.653 1.00 39.79 ? 59  TYR A C   1 
ATOM   159  O  O   . TYR A 1 59  ? 196.557 210.193 300.810 1.00 39.79 ? 59  TYR A O   1 
ATOM   160  C  CB  . TYR A 1 59  ? 195.739 211.645 298.018 1.00 39.79 ? 59  TYR A CB  1 
ATOM   161  C  CG  . TYR A 1 59  ? 196.847 212.263 297.211 1.00 39.79 ? 59  TYR A CG  1 
ATOM   162  C  CD1 . TYR A 1 59  ? 196.950 212.037 295.854 1.00 39.79 ? 59  TYR A CD1 1 
ATOM   163  C  CD2 . TYR A 1 59  ? 197.772 213.098 297.802 1.00 39.79 ? 59  TYR A CD2 1 
ATOM   164  C  CE1 . TYR A 1 59  ? 197.953 212.608 295.119 1.00 39.79 ? 59  TYR A CE1 1 
ATOM   165  C  CE2 . TYR A 1 59  ? 198.778 213.672 297.073 1.00 39.79 ? 59  TYR A CE2 1 
ATOM   166  C  CZ  . TYR A 1 59  ? 198.865 213.424 295.735 1.00 39.79 ? 59  TYR A CZ  1 
ATOM   167  O  OH  . TYR A 1 59  ? 199.873 213.999 295.006 1.00 39.79 ? 59  TYR A OH  1 
ATOM   168  N  N   . ARG A 1 60  ? 198.264 210.243 299.350 1.00 42.51 ? 60  ARG A N   1 
ATOM   169  C  CA  . ARG A 1 60  ? 199.310 210.193 300.361 1.00 42.51 ? 60  ARG A CA  1 
ATOM   170  C  C   . ARG A 1 60  ? 200.264 211.354 300.151 1.00 42.51 ? 60  ARG A C   1 
ATOM   171  O  O   . ARG A 1 60  ? 200.748 211.569 299.039 1.00 42.51 ? 60  ARG A O   1 
ATOM   172  C  CB  . ARG A 1 60  ? 200.070 208.877 300.300 1.00 42.51 ? 60  ARG A CB  1 
ATOM   173  C  CG  . ARG A 1 60  ? 200.740 208.487 301.587 1.00 42.51 ? 60  ARG A CG  1 
ATOM   174  C  CD  . ARG A 1 60  ? 202.005 207.691 301.302 1.00 42.51 ? 60  ARG A CD  1 
ATOM   175  N  NE  . ARG A 1 60  ? 202.564 207.075 302.500 1.00 42.51 ? 60  ARG A NE  1 
ATOM   176  C  CZ  . ARG A 1 60  ? 202.015 206.054 303.146 1.00 42.51 ? 60  ARG A CZ  1 
ATOM   177  N  NH1 . ARG A 1 60  ? 200.892 205.493 302.728 1.00 42.51 ? 60  ARG A NH1 1 
ATOM   178  N  NH2 . ARG A 1 60  ? 202.612 205.579 304.234 1.00 42.51 ? 60  ARG A NH2 1 
ATOM   179  N  N   . VAL A 1 61  ? 200.549 212.084 301.221 1.00 39.48 ? 61  VAL A N   1 
ATOM   180  C  CA  . VAL A 1 61  ? 201.474 213.204 301.193 1.00 39.48 ? 61  VAL A CA  1 
ATOM   181  C  C   . VAL A 1 61  ? 202.567 212.925 302.204 1.00 39.48 ? 61  VAL A C   1 
ATOM   182  O  O   . VAL A 1 61  ? 202.286 212.693 303.382 1.00 39.48 ? 61  VAL A O   1 
ATOM   183  C  CB  . VAL A 1 61  ? 200.762 214.526 301.510 1.00 39.48 ? 61  VAL A CB  1 
ATOM   184  C  CG1 . VAL A 1 61  ? 201.742 215.548 302.016 1.00 39.48 ? 61  VAL A CG1 1 
ATOM   185  C  CG2 . VAL A 1 61  ? 200.059 215.051 300.287 1.00 39.48 ? 61  VAL A CG2 1 
ATOM   186  N  N   . ASN A 1 62  ? 203.809 212.949 301.748 1.00 43.70 ? 62  ASN A N   1 
ATOM   187  C  CA  . ASN A 1 62  ? 204.954 212.644 302.590 1.00 43.70 ? 62  ASN A CA  1 
ATOM   188  C  C   . ASN A 1 62  ? 205.422 213.924 303.259 1.00 43.70 ? 62  ASN A C   1 
ATOM   189  O  O   . ASN A 1 62  ? 205.798 214.881 302.579 1.00 43.70 ? 62  ASN A O   1 
ATOM   190  C  CB  . ASN A 1 62  ? 206.080 212.025 301.771 1.00 43.70 ? 62  ASN A CB  1 
ATOM   191  C  CG  . ASN A 1 62  ? 205.758 210.627 301.311 1.00 43.70 ? 62  ASN A CG  1 
ATOM   192  O  OD1 . ASN A 1 62  ? 205.754 209.688 302.102 1.00 43.70 ? 62  ASN A OD1 1 
ATOM   193  N  ND2 . ASN A 1 62  ? 205.492 210.478 300.023 1.00 43.70 ? 62  ASN A ND2 1 
ATOM   194  N  N   . ARG A 1 63  ? 205.431 213.933 304.586 1.00 43.92 ? 63  ARG A N   1 
ATOM   195  C  CA  . ARG A 1 63  ? 205.782 215.114 305.356 1.00 43.92 ? 63  ARG A CA  1 
ATOM   196  C  C   . ARG A 1 63  ? 207.087 214.895 306.089 1.00 43.92 ? 63  ARG A C   1 
ATOM   197  O  O   . ARG A 1 63  ? 207.261 213.895 306.784 1.00 43.92 ? 63  ARG A O   1 
ATOM   198  C  CB  . ARG A 1 63  ? 204.704 215.485 306.368 1.00 43.92 ? 63  ARG A CB  1 
ATOM   199  C  CG  . ARG A 1 63  ? 203.323 215.320 305.874 1.00 43.92 ? 63  ARG A CG  1 
ATOM   200  C  CD  . ARG A 1 63  ? 202.340 215.713 306.936 1.00 43.92 ? 63  ARG A CD  1 
ATOM   201  N  NE  . ARG A 1 63  ? 202.200 214.718 307.987 1.00 43.92 ? 63  ARG A NE  1 
ATOM   202  C  CZ  . ARG A 1 63  ? 201.555 214.932 309.124 1.00 43.92 ? 63  ARG A CZ  1 
ATOM   203  N  NH1 . ARG A 1 63  ? 201.008 216.103 309.394 1.00 43.92 ? 63  ARG A NH1 1 
ATOM   204  N  NH2 . ARG A 1 63  ? 201.419 213.935 309.989 1.00 43.92 ? 63  ARG A NH2 1 
ATOM   205  N  N   . ARG A 1 64  ? 207.978 215.859 305.950 1.00 51.59 ? 64  ARG A N   1 
ATOM   206  C  CA  . ARG A 1 64  ? 209.165 215.977 306.769 1.00 51.59 ? 64  ARG A CA  1 
ATOM   207  C  C   . ARG A 1 64  ? 208.913 217.060 307.805 1.00 51.59 ? 64  ARG A C   1 
ATOM   208  O  O   . ARG A 1 64  ? 208.517 218.174 307.455 1.00 51.59 ? 64  ARG A O   1 
ATOM   209  C  CB  . ARG A 1 64  ? 210.344 216.334 305.869 1.00 51.59 ? 64  ARG A CB  1 
ATOM   210  C  CG  . ARG A 1 64  ? 211.681 215.942 306.388 1.00 51.59 ? 64  ARG A CG  1 
ATOM   211  C  CD  . ARG A 1 64  ? 212.785 216.368 305.430 1.00 51.59 ? 64  ARG A CD  1 
ATOM   212  N  NE  . ARG A 1 64  ? 213.294 217.705 305.698 1.00 51.59 ? 64  ARG A NE  1 
ATOM   213  C  CZ  . ARG A 1 64  ? 214.005 218.031 306.767 1.00 51.59 ? 64  ARG A CZ  1 
ATOM   214  N  NH1 . ARG A 1 64  ? 214.368 217.124 307.659 1.00 51.59 ? 64  ARG A NH1 1 
ATOM   215  N  NH2 . ARG A 1 64  ? 214.392 219.292 306.930 1.00 51.59 ? 64  ARG A NH2 1 
ATOM   216  N  N   . LEU A 1 65  ? 209.132 216.734 309.077 1.00 50.95 ? 65  LEU A N   1 
ATOM   217  C  CA  . LEU A 1 65  ? 208.895 217.667 310.176 1.00 50.95 ? 65  LEU A CA  1 
ATOM   218  C  C   . LEU A 1 65  ? 210.186 217.900 310.943 1.00 50.95 ? 65  LEU A C   1 
ATOM   219  O  O   . LEU A 1 65  ? 210.461 217.221 311.931 1.00 50.95 ? 65  LEU A O   1 
ATOM   220  C  CB  . LEU A 1 65  ? 207.825 217.135 311.095 1.00 50.95 ? 65  LEU A CB  1 
ATOM   221  C  CG  . LEU A 1 65  ? 206.500 216.734 310.461 1.00 50.95 ? 65  LEU A CG  1 
ATOM   222  C  CD1 . LEU A 1 65  ? 205.543 216.327 311.541 1.00 50.95 ? 65  LEU A CD1 1 
ATOM   223  C  CD2 . LEU A 1 65  ? 205.915 217.868 309.642 1.00 50.95 ? 65  LEU A CD2 1 
ATOM   224  N  N   . THR A 1 66  ? 210.972 218.870 310.496 1.00 54.58 ? 66  THR A N   1 
ATOM   225  C  CA  . THR A 1 66  ? 212.222 219.183 311.171 1.00 54.58 ? 66  THR A CA  1 
ATOM   226  C  C   . THR A 1 66  ? 211.973 219.903 312.488 1.00 54.58 ? 66  THR A C   1 
ATOM   227  O  O   . THR A 1 66  ? 211.214 220.873 312.545 1.00 54.58 ? 66  THR A O   1 
ATOM   228  C  CB  . THR A 1 66  ? 213.103 220.038 310.265 1.00 54.58 ? 66  THR A CB  1 
ATOM   229  O  OG1 . THR A 1 66  ? 213.786 219.193 309.336 1.00 54.58 ? 66  THR A OG1 1 
ATOM   230  C  CG2 . THR A 1 66  ? 214.123 220.824 311.072 1.00 54.58 ? 66  THR A CG2 1 
ATOM   231  N  N   . PHE A 1 67  ? 212.601 219.416 313.553 1.00 56.20 ? 67  PHE A N   1 
ATOM   232  C  CA  . PHE A 1 67  ? 212.464 220.025 314.863 1.00 56.20 ? 67  PHE A CA  1 
ATOM   233  C  C   . PHE A 1 67  ? 213.789 219.892 315.595 1.00 56.20 ? 67  PHE A C   1 
ATOM   234  O  O   . PHE A 1 67  ? 214.563 218.969 315.335 1.00 56.20 ? 67  PHE A O   1 
ATOM   235  C  CB  . PHE A 1 67  ? 211.347 219.373 315.668 1.00 56.20 ? 67  PHE A CB  1 
ATOM   236  C  CG  . PHE A 1 67  ? 211.606 217.940 316.001 1.00 56.20 ? 67  PHE A CG  1 
ATOM   237  C  CD1 . PHE A 1 67  ? 211.395 216.951 315.065 1.00 56.20 ? 67  PHE A CD1 1 
ATOM   238  C  CD2 . PHE A 1 67  ? 212.046 217.578 317.253 1.00 56.20 ? 67  PHE A CD2 1 
ATOM   239  C  CE1 . PHE A 1 67  ? 211.628 215.637 315.369 1.00 56.20 ? 67  PHE A CE1 1 
ATOM   240  C  CE2 . PHE A 1 67  ? 212.279 216.268 317.558 1.00 56.20 ? 67  PHE A CE2 1 
ATOM   241  C  CZ  . PHE A 1 67  ? 212.068 215.297 316.617 1.00 56.20 ? 67  PHE A CZ  1 
ATOM   242  N  N   . THR A 1 68  ? 214.034 220.805 316.528 1.00 58.52 ? 68  THR A N   1 
ATOM   243  C  CA  . THR A 1 68  ? 215.237 220.801 317.345 1.00 58.52 ? 68  THR A CA  1 
ATOM   244  C  C   . THR A 1 68  ? 214.839 220.758 318.809 1.00 58.52 ? 68  THR A C   1 
ATOM   245  O  O   . THR A 1 68  ? 213.805 221.302 319.200 1.00 58.52 ? 68  THR A O   1 
ATOM   246  C  CB  . THR A 1 68  ? 216.113 222.024 317.093 1.00 58.52 ? 68  THR A CB  1 
ATOM   247  O  OG1 . THR A 1 68  ? 215.395 223.208 317.449 1.00 58.52 ? 68  THR A OG1 1 
ATOM   248  C  CG2 . THR A 1 68  ? 216.483 222.102 315.635 1.00 58.52 ? 68  THR A CG2 1 
ATOM   249  N  N   . VAL A 1 69  ? 215.658 220.107 319.618 1.00 59.22 ? 69  VAL A N   1 
ATOM   250  C  CA  . VAL A 1 69  ? 215.384 219.957 321.039 1.00 59.22 ? 69  VAL A CA  1 
ATOM   251  C  C   . VAL A 1 69  ? 216.261 220.926 321.815 1.00 59.22 ? 69  VAL A C   1 
ATOM   252  O  O   . VAL A 1 69  ? 217.480 220.972 321.614 1.00 59.22 ? 69  VAL A O   1 
ATOM   253  C  CB  . VAL A 1 69  ? 215.614 218.515 321.504 1.00 59.22 ? 69  VAL A CB  1 
ATOM   254  C  CG1 . VAL A 1 69  ? 215.236 218.386 322.961 1.00 59.22 ? 69  VAL A CG1 1 
ATOM   255  C  CG2 . VAL A 1 69  ? 214.806 217.565 320.654 1.00 59.22 ? 69  VAL A CG2 1 
ATOM   256  N  N   . GLY A 1 70  ? 215.640 221.708 322.691 1.00 61.26 ? 70  GLY A N   1 
ATOM   257  C  CA  . GLY A 1 70  ? 216.356 222.643 323.525 1.00 61.26 ? 70  GLY A CA  1 
ATOM   258  C  C   . GLY A 1 70  ? 216.273 224.092 323.115 1.00 61.26 ? 70  GLY A C   1 
ATOM   259  O  O   . GLY A 1 70  ? 216.954 224.924 323.722 1.00 61.26 ? 70  GLY A O   1 
ATOM   260  N  N   . ASP A 1 71  ? 215.461 224.427 322.121 1.00 60.80 ? 71  ASP A N   1 
ATOM   261  C  CA  . ASP A 1 71  ? 215.315 225.809 321.687 1.00 60.80 ? 71  ASP A CA  1 
ATOM   262  C  C   . ASP A 1 71  ? 214.164 226.528 322.379 1.00 60.80 ? 71  ASP A C   1 
ATOM   263  O  O   . ASP A 1 71  ? 213.882 227.681 322.043 1.00 60.80 ? 71  ASP A O   1 
ATOM   264  C  CB  . ASP A 1 71  ? 215.149 225.873 320.167 1.00 60.80 ? 71  ASP A CB  1 
ATOM   265  C  CG  . ASP A 1 71  ? 214.070 224.956 319.663 1.00 60.80 ? 71  ASP A CG  1 
ATOM   266  O  OD1 . ASP A 1 71  ? 213.918 223.861 320.229 1.00 60.80 ? 71  ASP A OD1 1 
ATOM   267  O  OD2 . ASP A 1 71  ? 213.386 225.316 318.687 1.00 60.80 ? 71  ASP A OD2 1 
ATOM   268  N  N   . GLY A 1 72  ? 213.494 225.879 323.328 1.00 57.58 ? 72  GLY A N   1 
ATOM   269  C  CA  . GLY A 1 72  ? 212.435 226.511 324.080 1.00 57.58 ? 72  GLY A CA  1 
ATOM   270  C  C   . GLY A 1 72  ? 211.074 226.495 323.430 1.00 57.58 ? 72  GLY A C   1 
ATOM   271  O  O   . GLY A 1 72  ? 210.123 227.027 324.015 1.00 57.58 ? 72  GLY A O   1 
ATOM   272  N  N   . ARG A 1 73  ? 210.938 225.901 322.250 1.00 52.85 ? 73  ARG A N   1 
ATOM   273  C  CA  . ARG A 1 73  ? 209.669 225.843 321.543 1.00 52.85 ? 73  ARG A CA  1 
ATOM   274  C  C   . ARG A 1 73  ? 209.332 224.394 321.237 1.00 52.85 ? 73  ARG A C   1 
ATOM   275  O  O   . ARG A 1 73  ? 210.176 223.656 320.724 1.00 52.85 ? 73  ARG A O   1 
ATOM   276  C  CB  . ARG A 1 73  ? 209.734 226.648 320.251 1.00 52.85 ? 73  ARG A CB  1 
ATOM   277  C  CG  . ARG A 1 73  ? 209.107 228.015 320.353 1.00 52.85 ? 73  ARG A CG  1 
ATOM   278  C  CD  . ARG A 1 73  ? 208.713 228.550 318.988 1.00 52.85 ? 73  ARG A CD  1 
ATOM   279  N  NE  . ARG A 1 73  ? 207.741 227.690 318.326 1.00 52.85 ? 73  ARG A NE  1 
ATOM   280  C  CZ  . ARG A 1 73  ? 208.040 226.798 317.393 1.00 52.85 ? 73  ARG A CZ  1 
ATOM   281  N  NH1 . ARG A 1 73  ? 209.280 226.633 316.969 1.00 52.85 ? 73  ARG A NH1 1 
ATOM   282  N  NH2 . ARG A 1 73  ? 207.072 226.051 316.877 1.00 52.85 ? 73  ARG A NH2 1 
ATOM   283  N  N   . VAL A 1 74  ? 208.102 223.993 321.540 1.00 48.62 ? 74  VAL A N   1 
ATOM   284  C  CA  . VAL A 1 74  ? 207.635 222.639 321.271 1.00 48.62 ? 74  VAL A CA  1 
ATOM   285  C  C   . VAL A 1 74  ? 206.967 222.606 319.908 1.00 48.62 ? 74  VAL A C   1 
ATOM   286  O  O   . VAL A 1 74  ? 206.134 223.458 319.590 1.00 48.62 ? 74  VAL A O   1 
ATOM   287  C  CB  . VAL A 1 74  ? 206.672 222.157 322.366 1.00 48.62 ? 74  VAL A CB  1 
ATOM   288  C  CG1 . VAL A 1 74  ? 207.430 221.751 323.590 1.00 48.62 ? 74  VAL A CG1 1 
ATOM   289  C  CG2 . VAL A 1 74  ? 205.732 223.251 322.731 1.00 48.62 ? 74  VAL A CG2 1 
ATOM   290  N  N   . GLU A 1 75  ? 207.355 221.641 319.089 1.00 48.12 ? 75  GLU A N   1 
ATOM   291  C  CA  . GLU A 1 75  ? 206.786 221.464 317.766 1.00 48.12 ? 75  GLU A CA  1 
ATOM   292  C  C   . GLU A 1 75  ? 205.727 220.376 317.810 1.00 48.12 ? 75  GLU A C   1 
ATOM   293  O  O   . GLU A 1 75  ? 205.870 219.388 318.530 1.00 48.12 ? 75  GLU A O   1 
ATOM   294  C  CB  . GLU A 1 75  ? 207.864 221.105 316.748 1.00 48.12 ? 75  GLU A CB  1 
ATOM   295  C  CG  . GLU A 1 75  ? 208.309 222.265 315.879 1.00 48.12 ? 75  GLU A CG  1 
ATOM   296  C  CD  . GLU A 1 75  ? 209.420 223.083 316.508 1.00 48.12 ? 75  GLU A CD  1 
ATOM   297  O  OE1 . GLU A 1 75  ? 209.682 222.909 317.712 1.00 48.12 ? 75  GLU A OE1 1 
ATOM   298  O  OE2 . GLU A 1 75  ? 210.036 223.900 315.795 1.00 48.12 ? 75  GLU A OE2 1 
ATOM   299  N  N   . PHE A 1 76  ? 204.661 220.569 317.045 1.00 38.68 ? 76  PHE A N   1 
ATOM   300  C  CA  . PHE A 1 76  ? 203.524 219.669 317.023 1.00 38.68 ? 76  PHE A CA  1 
ATOM   301  C  C   . PHE A 1 76  ? 203.336 219.119 315.621 1.00 38.68 ? 76  PHE A C   1 
ATOM   302  O  O   . PHE A 1 76  ? 203.843 219.665 314.641 1.00 38.68 ? 76  PHE A O   1 
ATOM   303  C  CB  . PHE A 1 76  ? 202.238 220.365 317.467 1.00 38.68 ? 76  PHE A CB  1 
ATOM   304  C  CG  . PHE A 1 76  ? 202.334 221.030 318.796 1.00 38.68 ? 76  PHE A CG  1 
ATOM   305  C  CD1 . PHE A 1 76  ? 202.839 222.295 318.914 1.00 38.68 ? 76  PHE A CD1 1 
ATOM   306  C  CD2 . PHE A 1 76  ? 201.888 220.399 319.926 1.00 38.68 ? 76  PHE A CD2 1 
ATOM   307  C  CE1 . PHE A 1 76  ? 202.924 222.897 320.136 1.00 38.68 ? 76  PHE A CE1 1 
ATOM   308  C  CE2 . PHE A 1 76  ? 201.969 221.006 321.145 1.00 38.68 ? 76  PHE A CE2 1 
ATOM   309  C  CZ  . PHE A 1 76  ? 202.485 222.249 321.247 1.00 38.68 ? 76  PHE A CZ  1 
ATOM   310  N  N   . VAL A 1 77  ? 202.601 218.019 315.547 1.00 37.37 ? 77  VAL A N   1 
ATOM   311  C  CA  . VAL A 1 77  ? 202.155 217.414 314.304 1.00 37.37 ? 77  VAL A CA  1 
ATOM   312  C  C   . VAL A 1 77  ? 200.682 217.735 314.158 1.00 37.37 ? 77  VAL A C   1 
ATOM   313  O  O   . VAL A 1 77  ? 199.881 217.412 315.042 1.00 37.37 ? 77  VAL A O   1 
ATOM   314  C  CB  . VAL A 1 77  ? 202.382 215.900 314.302 1.00 37.37 ? 77  VAL A CB  1 
ATOM   315  C  CG1 . VAL A 1 77  ? 201.904 215.305 313.014 1.00 37.37 ? 77  VAL A CG1 1 
ATOM   316  C  CG2 . VAL A 1 77  ? 203.824 215.593 314.529 1.00 37.37 ? 77  VAL A CG2 1 
ATOM   317  N  N   . GLN A 1 78  ? 200.320 218.363 313.053 1.00 32.10 ? 78  GLN A N   1 
ATOM   318  C  CA  . GLN A 1 78  ? 198.959 218.804 312.816 1.00 32.10 ? 78  GLN A CA  1 
ATOM   319  C  C   . GLN A 1 78  ? 198.382 218.061 311.627 1.00 32.10 ? 78  GLN A C   1 
ATOM   320  O  O   . GLN A 1 78  ? 198.998 218.024 310.560 1.00 32.10 ? 78  GLN A O   1 
ATOM   321  C  CB  . GLN A 1 78  ? 198.939 220.297 312.548 1.00 32.10 ? 78  GLN A CB  1 
ATOM   322  C  CG  . GLN A 1 78  ? 197.707 220.757 311.854 1.00 32.10 ? 78  GLN A CG  1 
ATOM   323  C  CD  . GLN A 1 78  ? 197.684 222.232 311.722 1.00 32.10 ? 78  GLN A CD  1 
ATOM   324  O  OE1 . GLN A 1 78  ? 198.681 222.891 311.972 1.00 32.10 ? 78  GLN A OE1 1 
ATOM   325  N  NE2 . GLN A 1 78  ? 196.554 222.772 311.312 1.00 32.10 ? 78  GLN A NE2 1 
ATOM   326  N  N   . ASP A 1 79  ? 197.204 217.470 311.810 1.00 35.19 ? 79  ASP A N   1 
ATOM   327  C  CA  . ASP A 1 79  ? 196.466 216.817 310.734 1.00 35.19 ? 79  ASP A CA  1 
ATOM   328  C  C   . ASP A 1 79  ? 195.101 217.490 310.677 1.00 35.19 ? 79  ASP A C   1 
ATOM   329  O  O   . ASP A 1 79  ? 194.117 216.992 311.221 1.00 35.19 ? 79  ASP A O   1 
ATOM   330  C  CB  . ASP A 1 79  ? 196.341 215.333 310.979 1.00 35.19 ? 79  ASP A CB  1 
ATOM   331  C  CG  . ASP A 1 79  ? 197.679 214.642 311.101 1.00 35.19 ? 79  ASP A CG  1 
ATOM   332  O  OD1 . ASP A 1 79  ? 198.595 214.939 310.312 1.00 35.19 ? 79  ASP A OD1 1 
ATOM   333  O  OD2 . ASP A 1 79  ? 197.816 213.782 311.990 1.00 35.19 ? 79  ASP A OD2 1 
ATOM   334  N  N   . GLY A 1 80  ? 195.036 218.608 309.974 1.00 33.01 ? 80  GLY A N   1 
ATOM   335  C  CA  . GLY A 1 80  ? 193.843 219.424 309.973 1.00 33.01 ? 80  GLY A CA  1 
ATOM   336  C  C   . GLY A 1 80  ? 193.668 220.172 311.274 1.00 33.01 ? 80  GLY A C   1 
ATOM   337  O  O   . GLY A 1 80  ? 194.453 221.064 311.596 1.00 33.01 ? 80  GLY A O   1 
ATOM   338  N  N   . SER A 1 81  ? 192.641 219.819 312.032 1.00 33.94 ? 81  SER A N   1 
ATOM   339  C  CA  . SER A 1 81  ? 192.360 220.468 313.298 1.00 33.94 ? 81  SER A CA  1 
ATOM   340  C  C   . SER A 1 81  ? 192.822 219.663 314.501 1.00 33.94 ? 81  SER A C   1 
ATOM   341  O  O   . SER A 1 81  ? 192.752 220.170 315.622 1.00 33.94 ? 81  SER A O   1 
ATOM   342  C  CB  . SER A 1 81  ? 190.862 220.741 313.426 1.00 33.94 ? 81  SER A CB  1 
ATOM   343  O  OG  . SER A 1 81  ? 190.315 221.129 312.181 1.00 33.94 ? 81  SER A OG  1 
ATOM   344  N  N   . THR A 1 82  ? 193.276 218.430 314.309 1.00 36.81 ? 82  THR A N   1 
ATOM   345  C  CA  . THR A 1 82  ? 193.761 217.616 315.411 1.00 36.81 ? 82  THR A CA  1 
ATOM   346  C  C   . THR A 1 82  ? 195.276 217.694 315.457 1.00 36.81 ? 82  THR A C   1 
ATOM   347  O  O   . THR A 1 82  ? 195.950 217.485 314.446 1.00 36.81 ? 82  THR A O   1 
ATOM   348  C  CB  . THR A 1 82  ? 193.294 216.164 315.288 1.00 36.81 ? 82  THR A CB  1 
ATOM   349  O  OG1 . THR A 1 82  ? 193.878 215.383 316.334 1.00 36.81 ? 82  THR A OG1 1 
ATOM   350  C  CG2 . THR A 1 82  ? 193.679 215.570 313.966 1.00 36.81 ? 82  THR A CG2 1 
ATOM   351  N  N   . VAL A 1 83  ? 195.806 217.971 316.638 1.00 36.25 ? 83  VAL A N   1 
ATOM   352  C  CA  . VAL A 1 83  ? 197.225 218.219 316.807 1.00 36.25 ? 83  VAL A CA  1 
ATOM   353  C  C   . VAL A 1 83  ? 197.753 217.314 317.907 1.00 36.25 ? 83  VAL A C   1 
ATOM   354  O  O   . VAL A 1 83  ? 197.015 216.904 318.805 1.00 36.25 ? 83  VAL A O   1 
ATOM   355  C  CB  . VAL A 1 83  ? 197.471 219.708 317.124 1.00 36.25 ? 83  VAL A CB  1 
ATOM   356  C  CG1 . VAL A 1 83  ? 197.241 219.996 318.578 1.00 36.25 ? 83  VAL A CG1 1 
ATOM   357  C  CG2 . VAL A 1 83  ? 198.846 220.111 316.722 1.00 36.25 ? 83  VAL A CG2 1 
ATOM   358  N  N   . ARG A 1 84  ? 199.027 216.955 317.804 1.00 39.04 ? 84  ARG A N   1 
ATOM   359  C  CA  . ARG A 1 84  ? 199.641 216.120 318.822 1.00 39.04 ? 84  ARG A CA  1 
ATOM   360  C  C   . ARG A 1 84  ? 201.122 216.442 318.909 1.00 39.04 ? 84  ARG A C   1 
ATOM   361  O  O   . ARG A 1 84  ? 201.781 216.632 317.891 1.00 39.04 ? 84  ARG A O   1 
ATOM   362  C  CB  . ARG A 1 84  ? 199.424 214.641 318.523 1.00 39.04 ? 84  ARG A CB  1 
ATOM   363  C  CG  . ARG A 1 84  ? 200.005 214.180 317.220 1.00 39.04 ? 84  ARG A CG  1 
ATOM   364  C  CD  . ARG A 1 84  ? 199.797 212.697 317.045 1.00 39.04 ? 84  ARG A CD  1 
ATOM   365  N  NE  . ARG A 1 84  ? 200.306 212.215 315.768 1.00 39.04 ? 84  ARG A NE  1 
ATOM   366  C  CZ  . ARG A 1 84  ? 201.562 211.855 315.546 1.00 39.04 ? 84  ARG A CZ  1 
ATOM   367  N  NH1 . ARG A 1 84  ? 202.477 211.912 316.501 1.00 39.04 ? 84  ARG A NH1 1 
ATOM   368  N  NH2 . ARG A 1 84  ? 201.906 211.416 314.339 1.00 39.04 ? 84  ARG A NH2 1 
ATOM   369  N  N   . VAL A 1 85  ? 201.647 216.466 320.129 1.00 43.63 ? 85  VAL A N   1 
ATOM   370  C  CA  . VAL A 1 85  ? 203.026 216.881 320.338 1.00 43.63 ? 85  VAL A CA  1 
ATOM   371  C  C   . VAL A 1 85  ? 203.984 215.803 319.856 1.00 43.63 ? 85  VAL A C   1 
ATOM   372  O  O   . VAL A 1 85  ? 203.740 214.604 320.032 1.00 43.63 ? 85  VAL A O   1 
ATOM   373  C  CB  . VAL A 1 85  ? 203.258 217.222 321.818 1.00 43.63 ? 85  VAL A CB  1 
ATOM   374  C  CG1 . VAL A 1 85  ? 202.895 216.053 322.687 1.00 43.63 ? 85  VAL A CG1 1 
ATOM   375  C  CG2 . VAL A 1 85  ? 204.691 217.636 322.048 1.00 43.63 ? 85  VAL A CG2 1 
ATOM   376  N  N   . ILE A 1 86  ? 205.066 216.223 319.216 1.00 50.10 ? 86  ILE A N   1 
ATOM   377  C  CA  . ILE A 1 86  ? 206.114 215.270 318.832 1.00 50.10 ? 86  ILE A CA  1 
ATOM   378  C  C   . ILE A 1 86  ? 206.748 214.695 320.093 1.00 50.10 ? 86  ILE A C   1 
ATOM   379  O  O   . ILE A 1 86  ? 207.174 215.463 320.971 1.00 50.10 ? 86  ILE A O   1 
ATOM   380  C  CB  . ILE A 1 86  ? 207.163 215.948 317.962 1.00 50.10 ? 86  ILE A CB  1 
ATOM   381  C  CG1 . ILE A 1 86  ? 206.577 216.338 316.621 1.00 50.10 ? 86  ILE A CG1 1 
ATOM   382  C  CG2 . ILE A 1 86  ? 208.321 215.035 317.741 1.00 50.10 ? 86  ILE A CG2 1 
ATOM   383  C  CD1 . ILE A 1 86  ? 207.530 217.084 315.766 1.00 50.10 ? 86  ILE A CD1 1 
ATOM   384  N  N   . PRO A 1 87  ? 206.859 213.373 320.218 1.00 54.24 ? 87  PRO A N   1 
ATOM   385  C  CA  . PRO A 1 87  ? 207.405 212.798 321.457 1.00 54.24 ? 87  PRO A CA  1 
ATOM   386  C  C   . PRO A 1 87  ? 208.809 213.262 321.797 1.00 54.24 ? 87  PRO A C   1 
ATOM   387  O  O   . PRO A 1 87  ? 209.097 213.528 322.967 1.00 54.24 ? 87  PRO A O   1 
ATOM   388  C  CB  . PRO A 1 87  ? 207.353 211.290 321.188 1.00 54.24 ? 87  PRO A CB  1 
ATOM   389  C  CG  . PRO A 1 87  ? 207.250 211.161 319.715 1.00 54.24 ? 87  PRO A CG  1 
ATOM   390  C  CD  . PRO A 1 87  ? 206.488 212.337 319.247 1.00 54.24 ? 87  PRO A CD  1 
ATOM   391  N  N   . GLN A 1 88  ? 209.667 213.434 320.815 1.00 54.93 ? 88  GLN A N   1 
ATOM   392  C  CA  . GLN A 1 88  ? 211.013 213.835 321.124 1.00 54.93 ? 88  GLN A CA  1 
ATOM   393  C  C   . GLN A 1 88  ? 211.035 215.249 321.668 1.00 54.93 ? 88  GLN A C   1 
ATOM   394  O  O   . GLN A 1 88  ? 211.869 215.575 322.501 1.00 54.93 ? 88  GLN A O   1 
ATOM   395  C  CB  . GLN A 1 88  ? 211.876 213.740 319.881 1.00 54.93 ? 88  GLN A CB  1 
ATOM   396  C  CG  . GLN A 1 88  ? 211.912 212.356 319.263 1.00 54.93 ? 88  GLN A CG  1 
ATOM   397  C  CD  . GLN A 1 88  ? 210.983 212.228 318.076 1.00 54.93 ? 88  GLN A CD  1 
ATOM   398  O  OE1 . GLN A 1 88  ? 209.765 212.260 318.224 1.00 54.93 ? 88  GLN A OE1 1 
ATOM   399  N  NE2 . GLN A 1 88  ? 211.556 212.083 316.888 1.00 54.93 ? 88  GLN A NE2 1 
ATOM   400  N  N   . GLU A 1 89  ? 210.132 216.095 321.183 1.00 55.13 ? 89  GLU A N   1 
ATOM   401  C  CA  . GLU A 1 89  ? 210.093 217.489 321.618 1.00 55.13 ? 89  GLU A CA  1 
ATOM   402  C  C   . GLU A 1 89  ? 209.604 217.616 323.047 1.00 55.13 ? 89  GLU A C   1 
ATOM   403  O  O   . GLU A 1 89  ? 209.756 218.669 323.666 1.00 55.13 ? 89  GLU A O   1 
ATOM   404  C  CB  . GLU A 1 89  ? 209.182 218.304 320.700 1.00 55.13 ? 89  GLU A CB  1 
ATOM   405  C  CG  . GLU A 1 89  ? 209.847 218.787 319.423 1.00 55.13 ? 89  GLU A CG  1 
ATOM   406  C  CD  . GLU A 1 89  ? 210.472 220.160 319.574 1.00 55.13 ? 89  GLU A CD  1 
ATOM   407  O  OE1 . GLU A 1 89  ? 211.105 220.635 318.607 1.00 55.13 ? 89  GLU A OE1 1 
ATOM   408  O  OE2 . GLU A 1 89  ? 210.330 220.765 320.658 1.00 55.13 ? 89  GLU A OE2 1 
ATOM   409  N  N   . LEU A 1 90  ? 209.033 216.559 323.583 1.00 58.79 ? 90  LEU A N   1 
ATOM   410  C  CA  . LEU A 1 90  ? 208.480 216.611 324.915 1.00 58.79 ? 90  LEU A CA  1 
ATOM   411  C  C   . LEU A 1 90  ? 209.628 216.866 325.812 1.00 58.79 ? 90  LEU A C   1 
ATOM   412  O  O   . LEU A 1 90  ? 209.486 217.453 326.870 1.00 58.79 ? 90  LEU A O   1 
ATOM   413  C  CB  . LEU A 1 90  ? 207.811 215.283 325.245 1.00 58.79 ? 90  LEU A CB  1 
ATOM   414  C  CG  . LEU A 1 90  ? 206.522 215.328 326.048 1.00 58.79 ? 90  LEU A CG  1 
ATOM   415  C  CD1 . LEU A 1 90  ? 205.743 216.588 325.721 1.00 58.79 ? 90  LEU A CD1 1 
ATOM   416  C  CD2 . LEU A 1 90  ? 205.706 214.086 325.745 1.00 58.79 ? 90  LEU A CD2 1 
ATOM   417  N  N   . GLY A 1 91  ? 210.795 216.446 325.379 1.00 62.98 ? 91  GLY A N   1 
ATOM   418  C  CA  . GLY A 1 91  ? 211.982 216.633 326.176 1.00 62.98 ? 91  GLY A CA  1 
ATOM   419  C  C   . GLY A 1 91  ? 212.371 218.061 326.464 1.00 62.98 ? 91  GLY A C   1 
ATOM   420  O  O   . GLY A 1 91  ? 213.137 218.297 327.384 1.00 62.98 ? 91  GLY A O   1 
ATOM   421  N  N   . GLU A 1 92  ? 211.873 219.024 325.707 1.00 61.65 ? 92  GLU A N   1 
ATOM   422  C  CA  . GLU A 1 92  ? 212.227 220.388 326.073 1.00 61.65 ? 92  GLU A CA  1 
ATOM   423  C  C   . GLU A 1 92  ? 211.939 220.619 327.540 1.00 61.65 ? 92  GLU A C   1 
ATOM   424  O  O   . GLU A 1 92  ? 212.622 221.384 328.204 1.00 61.65 ? 92  GLU A O   1 
ATOM   425  C  CB  . GLU A 1 92  ? 211.446 221.391 325.220 1.00 61.65 ? 92  GLU A CB  1 
ATOM   426  C  CG  . GLU A 1 92  ? 212.300 222.489 324.613 1.00 61.65 ? 92  GLU A CG  1 
ATOM   427  C  CD  . GLU A 1 92  ? 212.383 222.398 323.103 1.00 61.65 ? 92  GLU A CD  1 
ATOM   428  O  OE1 . GLU A 1 92  ? 212.220 223.439 322.439 1.00 61.65 ? 92  GLU A OE1 1 
ATOM   429  O  OE2 . GLU A 1 92  ? 212.621 221.292 322.580 1.00 61.65 ? 92  GLU A OE2 1 
ATOM   430  N  N   . LEU A 1 93  ? 210.916 219.964 328.053 1.00 66.98 ? 93  LEU A N   1 
ATOM   431  C  CA  . LEU A 1 93  ? 210.558 220.100 329.450 1.00 66.98 ? 93  LEU A CA  1 
ATOM   432  C  C   . LEU A 1 93  ? 211.738 219.631 330.277 1.00 66.98 ? 93  LEU A C   1 
ATOM   433  O  O   . LEU A 1 93  ? 212.315 218.575 330.009 1.00 66.98 ? 93  LEU A O   1 
ATOM   434  C  CB  . LEU A 1 93  ? 209.316 219.279 329.783 1.00 66.98 ? 93  LEU A CB  1 
ATOM   435  C  CG  . LEU A 1 93  ? 207.941 219.822 329.400 1.00 66.98 ? 93  LEU A CG  1 
ATOM   436  C  CD1 . LEU A 1 93  ? 207.818 220.092 327.917 1.00 66.98 ? 93  LEU A CD1 1 
ATOM   437  C  CD2 . LEU A 1 93  ? 206.882 218.851 329.853 1.00 66.98 ? 93  LEU A CD2 1 
ATOM   438  N  N   . ALA A 1 94  ? 212.104 220.425 331.280 1.00 72.25 ? 94  ALA A N   1 
ATOM   439  C  CA  . ALA A 1 94  ? 213.264 220.085 332.090 1.00 72.25 ? 94  ALA A CA  1 
ATOM   440  C  C   . ALA A 1 94  ? 213.057 218.744 332.774 1.00 72.25 ? 94  ALA A C   1 
ATOM   441  O  O   . ALA A 1 94  ? 213.912 217.856 332.686 1.00 72.25 ? 94  ALA A O   1 
ATOM   442  C  CB  . ALA A 1 94  ? 213.526 221.189 333.112 1.00 72.25 ? 94  ALA A CB  1 
ATOM   443  N  N   . LEU A 1 95  ? 211.929 218.573 333.463 1.00 75.01 ? 95  LEU A N   1 
ATOM   444  C  CA  . LEU A 1 95  ? 211.700 217.321 334.164 1.00 75.01 ? 95  LEU A CA  1 
ATOM   445  C  C   . LEU A 1 95  ? 211.791 216.113 333.247 1.00 75.01 ? 95  LEU A C   1 
ATOM   446  O  O   . LEU A 1 95  ? 211.826 214.981 333.742 1.00 75.01 ? 95  LEU A O   1 
ATOM   447  C  CB  . LEU A 1 95  ? 210.276 217.355 334.707 1.00 75.01 ? 95  LEU A CB  1 
ATOM   448  C  CG  . LEU A 1 95  ? 209.508 216.183 335.311 1.00 75.01 ? 95  LEU A CG  1 
ATOM   449  C  CD1 . LEU A 1 95  ? 208.478 216.776 336.190 1.00 75.01 ? 95  LEU A CD1 1 
ATOM   450  C  CD2 . LEU A 1 95  ? 208.835 215.314 334.268 1.00 75.01 ? 95  LEU A CD2 1 
ATOM   451  N  N   . LEU A 1 96  ? 211.918 216.322 331.938 1.00 72.68 ? 96  LEU A N   1 
ATOM   452  C  CA  . LEU A 1 96  ? 212.071 215.223 331.004 1.00 72.68 ? 96  LEU A CA  1 
ATOM   453  C  C   . LEU A 1 96  ? 213.282 215.413 330.104 1.00 72.68 ? 96  LEU A C   1 
ATOM   454  O  O   . LEU A 1 96  ? 213.432 214.669 329.131 1.00 72.68 ? 96  LEU A O   1 
ATOM   455  C  CB  . LEU A 1 96  ? 210.788 215.075 330.183 1.00 72.68 ? 96  LEU A CB  1 
ATOM   456  C  CG  . LEU A 1 96  ? 210.196 213.683 329.996 1.00 72.68 ? 96  LEU A CG  1 
ATOM   457  C  CD1 . LEU A 1 96  ? 209.767 213.140 331.344 1.00 72.68 ? 96  LEU A CD1 1 
ATOM   458  C  CD2 . LEU A 1 96  ? 208.998 213.790 329.092 1.00 72.68 ? 96  LEU A CD2 1 
ATOM   459  N  N   . ARG A 1 97  ? 214.138 216.394 330.385 1.00 73.16 ? 97  ARG A N   1 
ATOM   460  C  CA  . ARG A 1 97  ? 215.314 216.582 329.553 1.00 73.16 ? 97  ARG A CA  1 
ATOM   461  C  C   . ARG A 1 97  ? 216.222 215.371 329.648 1.00 73.16 ? 97  ARG A C   1 
ATOM   462  O  O   . ARG A 1 97  ? 216.328 214.728 330.696 1.00 73.16 ? 97  ARG A O   1 
ATOM   463  C  CB  . ARG A 1 97  ? 216.084 217.827 329.982 1.00 73.16 ? 97  ARG A CB  1 
ATOM   464  C  CG  . ARG A 1 97  ? 216.998 218.390 328.910 1.00 73.16 ? 97  ARG A CG  1 
ATOM   465  C  CD  . ARG A 1 97  ? 216.267 218.640 327.617 1.00 73.16 ? 97  ARG A CD  1 
ATOM   466  N  NE  . ARG A 1 97  ? 215.422 219.824 327.696 1.00 73.16 ? 97  ARG A NE  1 
ATOM   467  C  CZ  . ARG A 1 97  ? 215.807 221.047 327.357 1.00 73.16 ? 97  ARG A CZ  1 
ATOM   468  N  NH1 . ARG A 1 97  ? 217.026 221.286 326.904 1.00 73.16 ? 97  ARG A NH1 1 
ATOM   469  N  NH2 . ARG A 1 97  ? 214.946 222.053 327.470 1.00 73.16 ? 97  ARG A NH2 1 
ATOM   470  N  N   . ASP A 1 98  ? 216.864 215.053 328.528 1.00 80.37 ? 98  ASP A N   1 
ATOM   471  C  CA  . ASP A 1 98  ? 217.871 214.010 328.395 1.00 80.37 ? 98  ASP A CA  1 
ATOM   472  C  C   . ASP A 1 98  ? 217.246 212.625 328.484 1.00 80.37 ? 98  ASP A C   1 
ATOM   473  O  O   . ASP A 1 98  ? 217.953 211.629 328.319 1.00 80.37 ? 98  ASP A O   1 
ATOM   474  C  CB  . ASP A 1 98  ? 218.999 214.139 329.428 1.00 80.37 ? 98  ASP A CB  1 
ATOM   475  C  CG  . ASP A 1 98  ? 220.247 214.789 328.848 1.00 80.37 ? 98  ASP A CG  1 
ATOM   476  O  OD1 . ASP A 1 98  ? 220.372 214.844 327.607 1.00 80.37 ? 98  ASP A OD1 1 
ATOM   477  O  OD2 . ASP A 1 98  ? 221.094 215.264 329.635 1.00 80.37 ? 98  ASP A OD2 1 
ATOM   478  N  N   . PHE A 1 99  ? 215.942 212.527 328.739 1.00 83.76 ? 99  PHE A N   1 
ATOM   479  C  CA  . PHE A 1 99  ? 215.241 211.256 328.638 1.00 83.76 ? 99  PHE A CA  1 
ATOM   480  C  C   . PHE A 1 99  ? 214.877 210.991 327.190 1.00 83.76 ? 99  PHE A C   1 
ATOM   481  O  O   . PHE A 1 99  ? 214.120 211.748 326.574 1.00 83.76 ? 99  PHE A O   1 
ATOM   482  C  CB  . PHE A 1 99  ? 213.981 211.262 329.497 1.00 83.76 ? 99  PHE A CB  1 
ATOM   483  C  CG  . PHE A 1 99  ? 213.535 209.905 329.909 1.00 83.76 ? 99  PHE A CG  1 
ATOM   484  C  CD1 . PHE A 1 99  ? 214.444 208.893 330.102 1.00 83.76 ? 99  PHE A CD1 1 
ATOM   485  C  CD2 . PHE A 1 99  ? 212.193 209.634 330.069 1.00 83.76 ? 99  PHE A CD2 1 
ATOM   486  C  CE1 . PHE A 1 99  ? 214.022 207.639 330.469 1.00 83.76 ? 99  PHE A CE1 1 
ATOM   487  C  CE2 . PHE A 1 99  ? 211.765 208.386 330.435 1.00 83.76 ? 99  PHE A CE2 1 
ATOM   488  C  CZ  . PHE A 1 99  ? 212.676 207.386 330.636 1.00 83.76 ? 99  PHE A CZ  1 
ATOM   489  N  N   . ASP A 1 100 ? 215.421 209.915 326.648 1.00 85.52 ? 100 ASP A N   1 
ATOM   490  C  CA  . ASP A 1 100 ? 215.313 209.619 325.230 1.00 85.52 ? 100 ASP A CA  1 
ATOM   491  C  C   . ASP A 1 100 ? 214.898 208.163 325.011 1.00 85.52 ? 100 ASP A C   1 
ATOM   492  O  O   . ASP A 1 100 ? 215.445 207.440 324.177 1.00 85.52 ? 100 ASP A O   1 
ATOM   493  C  CB  . ASP A 1 100 ? 216.627 210.022 324.563 1.00 85.52 ? 100 ASP A CB  1 
ATOM   494  C  CG  . ASP A 1 100 ? 217.822 209.614 325.369 1.00 85.52 ? 100 ASP A CG  1 
ATOM   495  O  OD1 . ASP A 1 100 ? 217.629 209.053 326.466 1.00 85.52 ? 100 ASP A OD1 1 
ATOM   496  O  OD2 . ASP A 1 100 ? 218.949 209.921 324.943 1.00 85.52 ? 100 ASP A OD2 1 
ATOM   497  N  N   . ASP A 1 101 ? 213.904 207.716 325.773 1.00 84.12 ? 101 ASP A N   1 
ATOM   498  C  CA  . ASP A 1 101 ? 213.299 206.404 325.588 1.00 84.12 ? 101 ASP A CA  1 
ATOM   499  C  C   . ASP A 1 101 ? 212.041 206.558 324.752 1.00 84.12 ? 101 ASP A C   1 
ATOM   500  O  O   . ASP A 1 101 ? 211.081 207.195 325.191 1.00 84.12 ? 101 ASP A O   1 
ATOM   501  C  CB  . ASP A 1 101 ? 212.979 205.745 326.931 1.00 84.12 ? 101 ASP A CB  1 
ATOM   502  C  CG  . ASP A 1 101 ? 214.215 205.235 327.651 1.00 84.12 ? 101 ASP A CG  1 
ATOM   503  O  OD1 . ASP A 1 101 ? 215.273 205.093 327.002 1.00 84.12 ? 101 ASP A OD1 1 
ATOM   504  O  OD2 . ASP A 1 101 ? 214.118 204.953 328.866 1.00 84.12 ? 101 ASP A OD2 1 
ATOM   505  N  N   . ALA A 1 102 ? 212.039 205.944 323.571 1.00 78.91 ? 102 ALA A N   1 
ATOM   506  C  CA  . ALA A 1 102 ? 210.947 206.143 322.631 1.00 78.91 ? 102 ALA A CA  1 
ATOM   507  C  C   . ALA A 1 102 ? 209.619 205.663 323.195 1.00 78.91 ? 102 ALA A C   1 
ATOM   508  O  O   . ALA A 1 102 ? 208.587 206.301 322.977 1.00 78.91 ? 102 ALA A O   1 
ATOM   509  C  CB  . ALA A 1 102 ? 211.259 205.439 321.320 1.00 78.91 ? 102 ALA A CB  1 
ATOM   510  N  N   . GLU A 1 103 ? 209.619 204.542 323.918 1.00 78.73 ? 103 GLU A N   1 
ATOM   511  C  CA  . GLU A 1 103 ? 208.368 204.021 324.467 1.00 78.73 ? 103 GLU A CA  1 
ATOM   512  C  C   . GLU A 1 103 ? 207.734 205.018 325.428 1.00 78.73 ? 103 GLU A C   1 
ATOM   513  O  O   . GLU A 1 103 ? 206.538 205.324 325.331 1.00 78.73 ? 103 GLU A O   1 
ATOM   514  C  CB  . GLU A 1 103 ? 208.613 202.685 325.167 1.00 78.73 ? 103 GLU A CB  1 
ATOM   515  C  CG  . GLU A 1 103 ? 209.304 201.648 324.301 1.00 78.73 ? 103 GLU A CG  1 
ATOM   516  C  CD  . GLU A 1 103 ? 209.717 200.415 325.086 1.00 78.73 ? 103 GLU A CD  1 
ATOM   517  O  OE1 . GLU A 1 103 ? 209.826 200.504 326.330 1.00 78.73 ? 103 GLU A OE1 1 
ATOM   518  O  OE2 . GLU A 1 103 ? 209.932 199.358 324.458 1.00 78.73 ? 103 GLU A OE2 1 
ATOM   519  N  N   . VAL A 1 104 ? 208.526 205.538 326.363 1.00 77.06 ? 104 VAL A N   1 
ATOM   520  C  CA  . VAL A 1 104 ? 207.993 206.424 327.391 1.00 77.06 ? 104 VAL A CA  1 
ATOM   521  C  C   . VAL A 1 104 ? 207.487 207.718 326.771 1.00 77.06 ? 104 VAL A C   1 
ATOM   522  O  O   . VAL A 1 104 ? 206.379 208.175 327.071 1.00 77.06 ? 104 VAL A O   1 
ATOM   523  C  CB  . VAL A 1 104 ? 209.058 206.701 328.461 1.00 77.06 ? 104 VAL A CB  1 
ATOM   524  C  CG1 . VAL A 1 104 ? 208.479 207.584 329.545 1.00 77.06 ? 104 VAL A CG1 1 
ATOM   525  C  CG2 . VAL A 1 104 ? 209.568 205.392 329.042 1.00 77.06 ? 104 VAL A CG2 1 
ATOM   526  N  N   . LEU A 1 105 ? 208.300 208.339 325.917 1.00 70.19 ? 105 LEU A N   1 
ATOM   527  C  CA  . LEU A 1 105 ? 207.888 209.580 325.275 1.00 70.19 ? 105 LEU A CA  1 
ATOM   528  C  C   . LEU A 1 105 ? 206.644 209.369 324.428 1.00 70.19 ? 105 LEU A C   1 
ATOM   529  O  O   . LEU A 1 105 ? 205.731 210.198 324.441 1.00 70.19 ? 105 LEU A O   1 
ATOM   530  C  CB  . LEU A 1 105 ? 209.019 210.148 324.425 1.00 70.19 ? 105 LEU A CB  1 
ATOM   531  C  CG  . LEU A 1 105 ? 210.357 210.322 325.118 1.00 70.19 ? 105 LEU A CG  1 
ATOM   532  C  CD1 . LEU A 1 105 ? 211.402 210.699 324.099 1.00 70.19 ? 105 LEU A CD1 1 
ATOM   533  C  CD2 . LEU A 1 105 ? 210.246 211.371 326.198 1.00 70.19 ? 105 LEU A CD2 1 
ATOM   534  N  N   . SER A 1 106 ? 206.585 208.264 323.689 1.00 69.52 ? 106 SER A N   1 
ATOM   535  C  CA  . SER A 1 106 ? 205.411 207.985 322.873 1.00 69.52 ? 106 SER A CA  1 
ATOM   536  C  C   . SER A 1 106 ? 204.170 207.826 323.736 1.00 69.52 ? 106 SER A C   1 
ATOM   537  O  O   . SER A 1 106 ? 203.101 208.342 323.395 1.00 69.52 ? 106 SER A O   1 
ATOM   538  C  CB  . SER A 1 106 ? 205.644 206.737 322.030 1.00 69.52 ? 106 SER A CB  1 
ATOM   539  O  OG  . SER A 1 106 ? 206.122 207.086 320.745 1.00 69.52 ? 106 SER A OG  1 
ATOM   540  N  N   . ALA A 1 107 ? 204.287 207.119 324.858 1.00 70.06 ? 107 ALA A N   1 
ATOM   541  C  CA  . ALA A 1 107 ? 203.140 206.961 325.746 1.00 70.06 ? 107 ALA A CA  1 
ATOM   542  C  C   . ALA A 1 107 ? 202.692 208.308 326.299 1.00 70.06 ? 107 ALA A C   1 
ATOM   543  O  O   . ALA A 1 107 ? 201.496 208.623 326.304 1.00 70.06 ? 107 ALA A O   1 
ATOM   544  C  CB  . ALA A 1 107 ? 203.486 206.000 326.878 1.00 70.06 ? 107 ALA A CB  1 
ATOM   545  N  N   . ILE A 1 108 ? 203.641 209.123 326.763 1.00 67.50 ? 108 ILE A N   1 
ATOM   546  C  CA  . ILE A 1 108 ? 203.292 210.421 327.338 1.00 67.50 ? 108 ILE A CA  1 
ATOM   547  C  C   . ILE A 1 108 ? 202.620 211.300 326.292 1.00 67.50 ? 108 ILE A C   1 
ATOM   548  O  O   . ILE A 1 108 ? 201.608 211.954 326.562 1.00 67.50 ? 108 ILE A O   1 
ATOM   549  C  CB  . ILE A 1 108 ? 204.535 211.107 327.924 1.00 67.50 ? 108 ILE A CB  1 
ATOM   550  C  CG1 . ILE A 1 108 ? 205.157 210.243 329.009 1.00 67.50 ? 108 ILE A CG1 1 
ATOM   551  C  CG2 . ILE A 1 108 ? 204.145 212.437 328.519 1.00 67.50 ? 108 ILE A CG2 1 
ATOM   552  C  CD1 . ILE A 1 108 ? 205.967 211.019 329.993 1.00 67.50 ? 108 ILE A CD1 1 
ATOM   553  N  N   . ALA A 1 109 ? 203.157 211.303 325.076 1.00 64.74 ? 109 ALA A N   1 
ATOM   554  C  CA  . ALA A 1 109 ? 202.573 212.072 323.988 1.00 64.74 ? 109 ALA A CA  1 
ATOM   555  C  C   . ALA A 1 109 ? 201.171 211.586 323.675 1.00 64.74 ? 109 ALA A C   1 
ATOM   556  O  O   . ALA A 1 109 ? 200.278 212.388 323.391 1.00 64.74 ? 109 ALA A O   1 
ATOM   557  C  CB  . ALA A 1 109 ? 203.459 211.993 322.749 1.00 64.74 ? 109 ALA A CB  1 
ATOM   558  N  N   . ASP A 1 110 ? 200.963 210.276 323.690 1.00 66.58 ? 110 ASP A N   1 
ATOM   559  C  CA  . ASP A 1 110 ? 199.639 209.733 323.426 1.00 66.58 ? 110 ASP A CA  1 
ATOM   560  C  C   . ASP A 1 110 ? 198.652 210.091 324.526 1.00 66.58 ? 110 ASP A C   1 
ATOM   561  O  O   . ASP A 1 110 ? 197.449 210.170 324.267 1.00 66.58 ? 110 ASP A O   1 
ATOM   562  C  CB  . ASP A 1 110 ? 199.713 208.221 323.257 1.00 66.58 ? 110 ASP A CB  1 
ATOM   563  C  CG  . ASP A 1 110 ? 199.018 207.747 322.004 1.00 66.58 ? 110 ASP A CG  1 
ATOM   564  O  OD1 . ASP A 1 110 ? 198.370 208.576 321.334 1.00 66.58 ? 110 ASP A OD1 1 
ATOM   565  O  OD2 . ASP A 1 110 ? 199.120 206.547 321.684 1.00 66.58 ? 110 ASP A OD2 1 
ATOM   566  N  N   . ARG A 1 111 ? 199.111 210.318 325.720 1.00 66.48 ? 111 ARG A N   1 
ATOM   567  C  CA  . ARG A 1 111 ? 198.218 210.562 326.855 1.00 66.48 ? 111 ARG A CA  1 
ATOM   568  C  C   . ARG A 1 111 ? 197.866 212.007 327.138 1.00 66.48 ? 111 ARG A C   1 
ATOM   569  O  O   . ARG A 1 111 ? 197.350 212.314 328.206 1.00 66.48 ? 111 ARG A O   1 
ATOM   570  C  CB  . ARG A 1 111 ? 198.844 209.973 328.117 1.00 66.48 ? 111 ARG A CB  1 
ATOM   571  C  CG  . ARG A 1 111 ? 199.028 208.471 328.069 1.00 66.48 ? 111 ARG A CG  1 
ATOM   572  C  CD  . ARG A 1 111 ? 197.792 207.768 328.590 1.00 66.48 ? 111 ARG A CD  1 
ATOM   573  N  NE  . ARG A 1 111 ? 197.451 208.205 329.939 1.00 66.48 ? 111 ARG A NE  1 
ATOM   574  C  CZ  . ARG A 1 111 ? 196.232 208.125 330.459 1.00 66.48 ? 111 ARG A CZ  1 
ATOM   575  N  NH1 . ARG A 1 111 ? 195.238 207.625 329.739 1.00 66.48 ? 111 ARG A NH1 1 
ATOM   576  N  NH2 . ARG A 1 111 ? 196.005 208.541 331.695 1.00 66.48 ? 111 ARG A NH2 1 
ATOM   577  N  N   . CYS A 1 112 ? 198.191 212.916 326.229 1.00 58.15 ? 112 CYS A N   1 
ATOM   578  C  CA  . CYS A 1 112 ? 197.721 214.288 326.392 1.00 58.15 ? 112 CYS A CA  1 
ATOM   579  C  C   . CYS A 1 112 ? 196.405 214.503 325.642 1.00 58.15 ? 112 CYS A C   1 
ATOM   580  O  O   . CYS A 1 112 ? 196.088 213.799 324.683 1.00 58.15 ? 112 CYS A O   1 
ATOM   581  C  CB  . CYS A 1 112 ? 198.771 215.276 325.897 1.00 58.15 ? 112 CYS A CB  1 
ATOM   582  S  SG  . CYS A 1 112 ? 199.268 215.016 324.207 1.00 58.15 ? 112 CYS A SG  1 
ATOM   583  N  N   . VAL A 1 113 ? 195.646 215.508 326.076 1.00 48.14 ? 113 VAL A N   1 
ATOM   584  C  CA  . VAL A 1 113 ? 194.316 215.783 325.538 1.00 48.14 ? 113 VAL A CA  1 
ATOM   585  C  C   . VAL A 1 113 ? 194.303 217.161 324.894 1.00 48.14 ? 113 VAL A C   1 
ATOM   586  O  O   . VAL A 1 113 ? 194.796 218.124 325.481 1.00 48.14 ? 113 VAL A O   1 
ATOM   587  C  CB  . VAL A 1 113 ? 193.230 215.667 326.624 1.00 48.14 ? 113 VAL A CB  1 
ATOM   588  C  CG1 . VAL A 1 113 ? 193.568 216.528 327.816 1.00 48.14 ? 113 VAL A CG1 1 
ATOM   589  C  CG2 . VAL A 1 113 ? 191.875 216.046 326.070 1.00 48.14 ? 113 VAL A CG2 1 
ATOM   590  N  N   . GLN A 1 114 ? 193.731 217.262 323.702 1.00 41.93 ? 114 GLN A N   1 
ATOM   591  C  CA  . GLN A 1 114 ? 193.658 218.535 323.002 1.00 41.93 ? 114 GLN A CA  1 
ATOM   592  C  C   . GLN A 1 114 ? 192.411 219.317 323.389 1.00 41.93 ? 114 GLN A C   1 
ATOM   593  O  O   . GLN A 1 114 ? 191.313 218.763 323.461 1.00 41.93 ? 114 GLN A O   1 
ATOM   594  C  CB  . GLN A 1 114 ? 193.671 218.311 321.494 1.00 41.93 ? 114 GLN A CB  1 
ATOM   595  C  CG  . GLN A 1 114 ? 193.546 219.571 320.697 1.00 41.93 ? 114 GLN A CG  1 
ATOM   596  C  CD  . GLN A 1 114 ? 193.365 219.295 319.240 1.00 41.93 ? 114 GLN A CD  1 
ATOM   597  O  OE1 . GLN A 1 114 ? 193.604 218.187 318.784 1.00 41.93 ? 114 GLN A OE1 1 
ATOM   598  N  NE2 . GLN A 1 114 ? 192.921 220.290 318.498 1.00 41.93 ? 114 GLN A NE2 1 
ATOM   599  N  N   . ARG A 1 115 ? 192.619 220.615 323.614 1.00 47.60 ? 115 ARG A N   1 
ATOM   600  C  CA  . ARG A 1 115 ? 191.531 221.499 323.981 1.00 47.60 ? 115 ARG A CA  1 
ATOM   601  C  C   . ARG A 1 115 ? 191.595 222.772 323.159 1.00 47.60 ? 115 ARG A C   1 
ATOM   602  O  O   . ARG A 1 115 ? 192.672 223.203 322.786 1.00 47.60 ? 115 ARG A O   1 
ATOM   603  C  CB  . ARG A 1 115 ? 191.639 221.855 325.447 1.00 47.60 ? 115 ARG A CB  1 
ATOM   604  C  CG  . ARG A 1 115 ? 192.793 221.191 326.167 1.00 47.60 ? 115 ARG A CG  1 
ATOM   605  C  CD  . ARG A 1 115 ? 192.422 220.925 327.609 1.00 47.60 ? 115 ARG A CD  1 
ATOM   606  N  NE  . ARG A 1 115 ? 191.579 219.745 327.738 1.00 47.60 ? 115 ARG A NE  1 
ATOM   607  C  CZ  . ARG A 1 115 ? 191.432 219.058 328.864 1.00 47.60 ? 115 ARG A CZ  1 
ATOM   608  N  NH1 . ARG A 1 115 ? 192.075 219.435 329.959 1.00 47.60 ? 115 ARG A NH1 1 
ATOM   609  N  NH2 . ARG A 1 115 ? 190.644 217.994 328.894 1.00 47.60 ? 115 ARG A NH2 1 
ATOM   610  N  N   . ASP A 1 116 ? 190.455 223.380 322.874 1.00 49.55 ? 116 ASP A N   1 
ATOM   611  C  CA  . ASP A 1 116 ? 190.400 224.609 322.103 1.00 49.55 ? 116 ASP A CA  1 
ATOM   612  C  C   . ASP A 1 116 ? 189.890 225.711 323.013 1.00 49.55 ? 116 ASP A C   1 
ATOM   613  O  O   . ASP A 1 116 ? 189.050 225.471 323.881 1.00 49.55 ? 116 ASP A O   1 
ATOM   614  C  CB  . ASP A 1 116 ? 189.489 224.477 320.883 1.00 49.55 ? 116 ASP A CB  1 
ATOM   615  C  CG  . ASP A 1 116 ? 189.816 223.270 320.046 1.00 49.55 ? 116 ASP A CG  1 
ATOM   616  O  OD1 . ASP A 1 116 ? 189.962 222.176 320.624 1.00 49.55 ? 116 ASP A OD1 1 
ATOM   617  O  OD2 . ASP A 1 116 ? 189.918 223.409 318.810 1.00 49.55 ? 116 ASP A OD2 1 
ATOM   618  N  N   . PHE A 1 117 ? 190.424 226.909 322.837 1.00 49.85 ? 117 PHE A N   1 
ATOM   619  C  CA  . PHE A 1 117 ? 190.016 228.054 323.627 1.00 49.85 ? 117 PHE A CA  1 
ATOM   620  C  C   . PHE A 1 117 ? 189.650 229.212 322.718 1.00 49.85 ? 117 PHE A C   1 
ATOM   621  O  O   . PHE A 1 117 ? 190.308 229.451 321.702 1.00 49.85 ? 117 PHE A O   1 
ATOM   622  C  CB  . PHE A 1 117 ? 191.099 228.476 324.621 1.00 49.85 ? 117 PHE A CB  1 
ATOM   623  C  CG  . PHE A 1 117 ? 192.468 228.606 324.032 1.00 49.85 ? 117 PHE A CG  1 
ATOM   624  C  CD1 . PHE A 1 117 ? 192.867 229.786 323.454 1.00 49.85 ? 117 PHE A CD1 1 
ATOM   625  C  CD2 . PHE A 1 117 ? 193.366 227.566 324.086 1.00 49.85 ? 117 PHE A CD2 1 
ATOM   626  C  CE1 . PHE A 1 117 ? 194.120 229.923 322.934 1.00 49.85 ? 117 PHE A CE1 1 
ATOM   627  C  CE2 . PHE A 1 117 ? 194.625 227.705 323.554 1.00 49.85 ? 117 PHE A CE2 1 
ATOM   628  C  CZ  . PHE A 1 117 ? 194.997 228.885 322.980 1.00 49.85 ? 117 PHE A CZ  1 
ATOM   629  N  N   . ARG A 1 118 ? 188.587 229.915 323.086 1.00 57.22 ? 118 ARG A N   1 
ATOM   630  C  CA  . ARG A 1 118 ? 188.114 231.071 322.350 1.00 57.22 ? 118 ARG A CA  1 
ATOM   631  C  C   . ARG A 1 118 ? 188.724 232.341 322.924 1.00 57.22 ? 118 ARG A C   1 
ATOM   632  O  O   . ARG A 1 118 ? 189.281 232.359 324.021 1.00 57.22 ? 118 ARG A O   1 
ATOM   633  C  CB  . ARG A 1 118 ? 186.593 231.164 322.410 1.00 57.22 ? 118 ARG A CB  1 
ATOM   634  C  CG  . ARG A 1 118 ? 185.857 230.193 321.520 1.00 57.22 ? 118 ARG A CG  1 
ATOM   635  C  CD  . ARG A 1 118 ? 184.363 230.209 321.812 1.00 57.22 ? 118 ARG A CD  1 
ATOM   636  N  NE  . ARG A 1 118 ? 184.045 230.547 323.196 1.00 57.22 ? 118 ARG A NE  1 
ATOM   637  C  CZ  . ARG A 1 118 ? 184.285 229.769 324.245 1.00 57.22 ? 118 ARG A CZ  1 
ATOM   638  N  NH1 . ARG A 1 118 ? 184.832 228.572 324.110 1.00 57.22 ? 118 ARG A NH1 1 
ATOM   639  N  NH2 . ARG A 1 118 ? 183.962 230.202 325.461 1.00 57.22 ? 118 ARG A NH2 1 
ATOM   640  N  N   . ALA A 1 119 ? 188.577 233.423 322.175 1.00 58.38 ? 119 ALA A N   1 
ATOM   641  C  CA  . ALA A 1 119 ? 189.078 234.713 322.615 1.00 58.38 ? 119 ALA A CA  1 
ATOM   642  C  C   . ALA A 1 119 ? 188.361 235.175 323.872 1.00 58.38 ? 119 ALA A C   1 
ATOM   643  O  O   . ALA A 1 119 ? 187.142 235.049 323.997 1.00 58.38 ? 119 ALA A O   1 
ATOM   644  C  CB  . ALA A 1 119 ? 188.908 235.743 321.504 1.00 58.38 ? 119 ALA A CB  1 
ATOM   645  N  N   . GLY A 1 120 ? 189.136 235.679 324.826 1.00 60.39 ? 120 GLY A N   1 
ATOM   646  C  CA  . GLY A 1 120 ? 188.581 236.173 326.063 1.00 60.39 ? 120 GLY A CA  1 
ATOM   647  C  C   . GLY A 1 120 ? 188.253 235.118 327.090 1.00 60.39 ? 120 GLY A C   1 
ATOM   648  O  O   . GLY A 1 120 ? 187.762 235.463 328.170 1.00 60.39 ? 120 GLY A O   1 
ATOM   649  N  N   . GLU A 1 121 ? 188.520 233.853 326.802 1.00 61.38 ? 121 GLU A N   1 
ATOM   650  C  CA  . GLU A 1 121 ? 188.216 232.772 327.722 1.00 61.38 ? 121 GLU A CA  1 
ATOM   651  C  C   . GLU A 1 121 ? 189.355 232.597 328.714 1.00 61.38 ? 121 GLU A C   1 
ATOM   652  O  O   . GLU A 1 121 ? 190.530 232.629 328.342 1.00 61.38 ? 121 GLU A O   1 
ATOM   653  C  CB  . GLU A 1 121 ? 187.973 231.475 326.956 1.00 61.38 ? 121 GLU A CB  1 
ATOM   654  C  CG  . GLU A 1 121 ? 188.356 230.227 327.707 1.00 61.38 ? 121 GLU A CG  1 
ATOM   655  C  CD  . GLU A 1 121 ? 188.161 228.989 326.872 1.00 61.38 ? 121 GLU A CD  1 
ATOM   656  O  OE1 . GLU A 1 121 ? 187.707 229.123 325.719 1.00 61.38 ? 121 GLU A OE1 1 
ATOM   657  O  OE2 . GLU A 1 121 ? 188.450 227.882 327.368 1.00 61.38 ? 121 GLU A OE2 1 
ATOM   658  N  N   . THR A 1 122 ? 188.998 232.424 329.981 1.00 64.63 ? 122 THR A N   1 
ATOM   659  C  CA  . THR A 1 122 ? 189.969 232.215 331.046 1.00 64.63 ? 122 THR A CA  1 
ATOM   660  C  C   . THR A 1 122 ? 190.236 230.728 331.202 1.00 64.63 ? 122 THR A C   1 
ATOM   661  O  O   . THR A 1 122 ? 189.305 229.943 331.394 1.00 64.63 ? 122 THR A O   1 
ATOM   662  C  CB  . THR A 1 122 ? 189.462 232.800 332.361 1.00 64.63 ? 122 THR A CB  1 
ATOM   663  O  OG1 . THR A 1 122 ? 189.363 234.223 332.246 1.00 64.63 ? 122 THR A OG1 1 
ATOM   664  C  CG2 . THR A 1 122 ? 190.401 232.444 333.494 1.00 64.63 ? 122 THR A CG2 1 
ATOM   665  N  N   . LEU A 1 123 ? 191.507 230.345 331.118 1.00 64.49 ? 123 LEU A N   1 
ATOM   666  C  CA  . LEU A 1 123 ? 191.885 228.945 331.228 1.00 64.49 ? 123 LEU A CA  1 
ATOM   667  C  C   . LEU A 1 123 ? 192.191 228.542 332.664 1.00 64.49 ? 123 LEU A C   1 
ATOM   668  O  O   . LEU A 1 123 ? 191.703 227.515 333.142 1.00 64.49 ? 123 LEU A O   1 
ATOM   669  C  CB  . LEU A 1 123 ? 193.096 228.670 330.342 1.00 64.49 ? 123 LEU A CB  1 
ATOM   670  C  CG  . LEU A 1 123 ? 192.959 229.044 328.871 1.00 64.49 ? 123 LEU A CG  1 
ATOM   671  C  CD1 . LEU A 1 123 ? 194.122 228.475 328.130 1.00 64.49 ? 123 LEU A CD1 1 
ATOM   672  C  CD2 . LEU A 1 123 ? 191.654 228.542 328.287 1.00 64.49 ? 123 LEU A CD2 1 
ATOM   673  N  N   . VAL A 1 124 ? 193.017 229.319 333.351 1.00 71.54 ? 124 VAL A N   1 
ATOM   674  C  CA  . VAL A 1 124 ? 193.355 229.065 334.743 1.00 71.54 ? 124 VAL A CA  1 
ATOM   675  C  C   . VAL A 1 124 ? 193.131 230.344 335.532 1.00 71.54 ? 124 VAL A C   1 
ATOM   676  O  O   . VAL A 1 124 ? 193.177 231.448 334.984 1.00 71.54 ? 124 VAL A O   1 
ATOM   677  C  CB  . VAL A 1 124 ? 194.803 228.564 334.909 1.00 71.54 ? 124 VAL A CB  1 
ATOM   678  C  CG1 . VAL A 1 124 ? 194.981 227.230 334.215 1.00 71.54 ? 124 VAL A CG1 1 
ATOM   679  C  CG2 . VAL A 1 124 ? 195.775 229.588 334.365 1.00 71.54 ? 124 VAL A CG2 1 
ATOM   680  N  N   . GLU A 1 125 ? 192.871 230.189 336.826 1.00 78.60 ? 125 GLU A N   1 
ATOM   681  C  CA  . GLU A 1 125 ? 192.607 231.317 337.705 1.00 78.60 ? 125 GLU A CA  1 
ATOM   682  C  C   . GLU A 1 125 ? 193.542 231.257 338.900 1.00 78.60 ? 125 GLU A C   1 
ATOM   683  O  O   . GLU A 1 125 ? 193.922 230.176 339.354 1.00 78.60 ? 125 GLU A O   1 
ATOM   684  C  CB  . GLU A 1 125 ? 191.155 231.335 338.175 1.00 78.60 ? 125 GLU A CB  1 
ATOM   685  C  CG  . GLU A 1 125 ? 190.226 232.096 337.247 1.00 78.60 ? 125 GLU A CG  1 
ATOM   686  C  CD  . GLU A 1 125 ? 188.797 231.601 337.316 1.00 78.60 ? 125 GLU A CD  1 
ATOM   687  O  OE1 . GLU A 1 125 ? 188.585 230.455 337.767 1.00 78.60 ? 125 GLU A OE1 1 
ATOM   688  O  OE2 . GLU A 1 125 ? 187.886 232.357 336.917 1.00 78.60 ? 125 GLU A OE2 1 
ATOM   689  N  N   . ARG A 1 126 ? 193.911 232.431 339.401 1.00 80.22 ? 126 ARG A N   1 
ATOM   690  C  CA  . ARG A 1 126 ? 194.814 232.508 340.540 1.00 80.22 ? 126 ARG A CA  1 
ATOM   691  C  C   . ARG A 1 126 ? 194.176 231.919 341.789 1.00 80.22 ? 126 ARG A C   1 
ATOM   692  O  O   . ARG A 1 126 ? 192.989 232.123 342.059 1.00 80.22 ? 126 ARG A O   1 
ATOM   693  C  CB  . ARG A 1 126 ? 195.210 233.957 340.806 1.00 80.22 ? 126 ARG A CB  1 
ATOM   694  C  CG  . ARG A 1 126 ? 196.074 234.552 339.730 1.00 80.22 ? 126 ARG A CG  1 
ATOM   695  C  CD  . ARG A 1 126 ? 196.304 236.034 339.944 1.00 80.22 ? 126 ARG A CD  1 
ATOM   696  N  NE  . ARG A 1 126 ? 195.073 236.806 339.856 1.00 80.22 ? 126 ARG A NE  1 
ATOM   697  C  CZ  . ARG A 1 126 ? 195.009 238.121 340.005 1.00 80.22 ? 126 ARG A CZ  1 
ATOM   698  N  NH1 . ARG A 1 126 ? 196.090 238.840 340.259 1.00 80.22 ? 126 ARG A NH1 1 
ATOM   699  N  NH2 . ARG A 1 126 ? 193.834 238.731 339.890 1.00 80.22 ? 126 ARG A NH2 1 
ATOM   700  N  N   . GLY A 1 127 ? 194.972 231.173 342.550 1.00 80.64 ? 127 GLY A N   1 
ATOM   701  C  CA  . GLY A 1 127 ? 194.478 230.550 343.759 1.00 80.64 ? 127 GLY A CA  1 
ATOM   702  C  C   . GLY A 1 127 ? 194.126 229.091 343.569 1.00 80.64 ? 127 GLY A C   1 
ATOM   703  O  O   . GLY A 1 127 ? 194.320 228.267 344.468 1.00 80.64 ? 127 GLY A O   1 
ATOM   704  N  N   . THR A 1 128 ? 193.596 228.764 342.397 1.00 81.05 ? 128 THR A N   1 
ATOM   705  C  CA  . THR A 1 128 ? 193.268 227.383 342.090 1.00 81.05 ? 128 THR A CA  1 
ATOM   706  C  C   . THR A 1 128 ? 194.542 226.556 341.984 1.00 81.05 ? 128 THR A C   1 
ATOM   707  O  O   . THR A 1 128 ? 195.537 226.993 341.403 1.00 81.05 ? 128 THR A O   1 
ATOM   708  C  CB  . THR A 1 128 ? 192.463 227.311 340.795 1.00 81.05 ? 128 THR A CB  1 
ATOM   709  O  OG1 . THR A 1 128 ? 191.087 227.595 341.076 1.00 81.05 ? 128 THR A OG1 1 
ATOM   710  C  CG2 . THR A 1 128 ? 192.566 225.930 340.166 1.00 81.05 ? 128 THR A CG2 1 
ATOM   711  N  N   . ALA A 1 129 ? 194.519 225.373 342.590 1.00 80.58 ? 129 ALA A N   1 
ATOM   712  C  CA  . ALA A 1 129 ? 195.680 224.497 342.568 1.00 80.58 ? 129 ALA A CA  1 
ATOM   713  C  C   . ALA A 1 129 ? 195.998 224.068 341.143 1.00 80.58 ? 129 ALA A C   1 
ATOM   714  O  O   . ALA A 1 129 ? 195.102 223.774 340.348 1.00 80.58 ? 129 ALA A O   1 
ATOM   715  C  CB  . ALA A 1 129 ? 195.432 223.272 343.444 1.00 80.58 ? 129 ALA A CB  1 
ATOM   716  N  N   . ALA A 1 130 ? 197.286 224.043 340.821 1.00 80.54 ? 130 ALA A N   1 
ATOM   717  C  CA  . ALA A 1 130 ? 197.752 223.680 339.491 1.00 80.54 ? 130 ALA A CA  1 
ATOM   718  C  C   . ALA A 1 130 ? 197.906 222.170 339.394 1.00 80.54 ? 130 ALA A C   1 
ATOM   719  O  O   . ALA A 1 130 ? 198.573 221.554 340.229 1.00 80.54 ? 130 ALA A O   1 
ATOM   720  C  CB  . ALA A 1 130 ? 199.078 224.368 339.174 1.00 80.54 ? 130 ALA A CB  1 
ATOM   721  N  N   . ASP A 1 131 ? 197.270 221.577 338.391 1.00 76.26 ? 131 ASP A N   1 
ATOM   722  C  CA  . ASP A 1 131 ? 197.336 220.136 338.212 1.00 76.26 ? 131 ASP A CA  1 
ATOM   723  C  C   . ASP A 1 131 ? 197.501 219.709 336.764 1.00 76.26 ? 131 ASP A C   1 
ATOM   724  O  O   . ASP A 1 131 ? 197.494 218.506 336.495 1.00 76.26 ? 131 ASP A O   1 
ATOM   725  C  CB  . ASP A 1 131 ? 196.074 219.481 338.780 1.00 76.26 ? 131 ASP A CB  1 
ATOM   726  C  CG  . ASP A 1 131 ? 194.815 220.244 338.420 1.00 76.26 ? 131 ASP A CG  1 
ATOM   727  O  OD1 . ASP A 1 131 ? 194.904 221.189 337.611 1.00 76.26 ? 131 ASP A OD1 1 
ATOM   728  O  OD2 . ASP A 1 131 ? 193.737 219.898 338.942 1.00 76.26 ? 131 ASP A OD2 1 
ATOM   729  N  N   . GLU A 1 132 ? 197.644 220.643 335.830 1.00 67.43 ? 132 GLU A N   1 
ATOM   730  C  CA  . GLU A 1 132 ? 197.720 220.338 334.412 1.00 67.43 ? 132 GLU A CA  1 
ATOM   731  C  C   . GLU A 1 132 ? 198.858 221.122 333.781 1.00 67.43 ? 132 GLU A C   1 
ATOM   732  O  O   . GLU A 1 132 ? 199.077 222.287 334.114 1.00 67.43 ? 132 GLU A O   1 
ATOM   733  C  CB  . GLU A 1 132 ? 196.410 220.676 333.701 1.00 67.43 ? 132 GLU A CB  1 
ATOM   734  C  CG  . GLU A 1 132 ? 195.189 220.025 334.320 1.00 67.43 ? 132 GLU A CG  1 
ATOM   735  C  CD  . GLU A 1 132 ? 194.062 219.817 333.332 1.00 67.43 ? 132 GLU A CD  1 
ATOM   736  O  OE1 . GLU A 1 132 ? 193.468 220.821 332.888 1.00 67.43 ? 132 GLU A OE1 1 
ATOM   737  O  OE2 . GLU A 1 132 ? 193.765 218.648 333.008 1.00 67.43 ? 132 GLU A OE2 1 
ATOM   738  N  N   . LEU A 1 133 ? 199.575 220.478 332.871 1.00 58.40 ? 133 LEU A N   1 
ATOM   739  C  CA  . LEU A 1 133 ? 200.579 221.129 332.047 1.00 58.40 ? 133 LEU A CA  1 
ATOM   740  C  C   . LEU A 1 133 ? 199.940 221.507 330.723 1.00 58.40 ? 133 LEU A C   1 
ATOM   741  O  O   . LEU A 1 133 ? 199.374 220.652 330.040 1.00 58.40 ? 133 LEU A O   1 
ATOM   742  C  CB  . LEU A 1 133 ? 201.763 220.205 331.803 1.00 58.40 ? 133 LEU A CB  1 
ATOM   743  C  CG  . LEU A 1 133 ? 202.544 220.547 330.547 1.00 58.40 ? 133 LEU A CG  1 
ATOM   744  C  CD1 . LEU A 1 133 ? 203.367 221.778 330.772 1.00 58.40 ? 133 LEU A CD1 1 
ATOM   745  C  CD2 . LEU A 1 133 ? 203.412 219.388 330.161 1.00 58.40 ? 133 LEU A CD2 1 
ATOM   746  N  N   . HIS A 1 134 ? 200.028 222.779 330.363 1.00 53.96 ? 134 HIS A N   1 
ATOM   747  C  CA  . HIS A 1 134 ? 199.418 223.292 329.147 1.00 53.96 ? 134 HIS A CA  1 
ATOM   748  C  C   . HIS A 1 134 ? 200.509 223.656 328.156 1.00 53.96 ? 134 HIS A C   1 
ATOM   749  O  O   . HIS A 1 134 ? 201.364 224.492 328.453 1.00 53.96 ? 134 HIS A O   1 
ATOM   750  C  CB  . HIS A 1 134 ? 198.548 224.508 329.446 1.00 53.96 ? 134 HIS A CB  1 
ATOM   751  C  CG  . HIS A 1 134 ? 197.383 224.212 330.335 1.00 53.96 ? 134 HIS A CG  1 
ATOM   752  N  ND1 . HIS A 1 134 ? 196.569 225.197 330.847 1.00 53.96 ? 134 HIS A ND1 1 
ATOM   753  C  CD2 . HIS A 1 134 ? 196.903 223.043 330.814 1.00 53.96 ? 134 HIS A CD2 1 
ATOM   754  C  CE1 . HIS A 1 134 ? 195.628 224.647 331.591 1.00 53.96 ? 134 HIS A CE1 1 
ATOM   755  N  NE2 . HIS A 1 134 ? 195.810 223.340 331.589 1.00 53.96 ? 134 HIS A NE2 1 
ATOM   756  N  N   . LEU A 1 135 ? 200.479 223.031 326.987 1.00 44.68 ? 135 LEU A N   1 
ATOM   757  C  CA  . LEU A 1 135 ? 201.374 223.359 325.888 1.00 44.68 ? 135 LEU A CA  1 
ATOM   758  C  C   . LEU A 1 135 ? 200.576 224.097 324.826 1.00 44.68 ? 135 LEU A C   1 
ATOM   759  O  O   . LEU A 1 135 ? 199.578 223.577 324.327 1.00 44.68 ? 135 LEU A O   1 
ATOM   760  C  CB  . LEU A 1 135 ? 202.005 222.101 325.300 1.00 44.68 ? 135 LEU A CB  1 
ATOM   761  C  CG  . LEU A 1 135 ? 202.910 221.278 326.206 1.00 44.68 ? 135 LEU A CG  1 
ATOM   762  C  CD1 . LEU A 1 135 ? 202.873 219.833 325.793 1.00 44.68 ? 135 LEU A CD1 1 
ATOM   763  C  CD2 . LEU A 1 135 ? 204.319 221.801 326.120 1.00 44.68 ? 135 LEU A CD2 1 
ATOM   764  N  N   . ILE A 1 136 ? 201.021 225.296 324.474 1.00 41.38 ? 136 ILE A N   1 
ATOM   765  C  CA  . ILE A 1 136 ? 200.301 226.134 323.522 1.00 41.38 ? 136 ILE A CA  1 
ATOM   766  C  C   . ILE A 1 136 ? 200.665 225.692 322.116 1.00 41.38 ? 136 ILE A C   1 
ATOM   767  O  O   . ILE A 1 136 ? 201.839 225.681 321.744 1.00 41.38 ? 136 ILE A O   1 
ATOM   768  C  CB  . ILE A 1 136 ? 200.614 227.619 323.724 1.00 41.38 ? 136 ILE A CB  1 
ATOM   769  C  CG1 . ILE A 1 136 ? 200.699 227.957 325.203 1.00 41.38 ? 136 ILE A CG1 1 
ATOM   770  C  CG2 . ILE A 1 136 ? 199.538 228.450 323.094 1.00 41.38 ? 136 ILE A CG2 1 
ATOM   771  C  CD1 . ILE A 1 136 ? 199.396 227.896 325.895 1.00 41.38 ? 136 ILE A CD1 1 
ATOM   772  N  N   . ALA A 1 137 ? 199.664 225.302 321.343 1.00 37.14 ? 137 ALA A N   1 
ATOM   773  C  CA  . ALA A 1 137 ? 199.865 224.955 319.947 1.00 37.14 ? 137 ALA A CA  1 
ATOM   774  C  C   . ALA A 1 137 ? 199.526 226.085 319.002 1.00 37.14 ? 137 ALA A C   1 
ATOM   775  O  O   . ALA A 1 137 ? 200.151 226.200 317.949 1.00 37.14 ? 137 ALA A O   1 
ATOM   776  C  CB  . ALA A 1 137 ? 199.026 223.738 319.571 1.00 37.14 ? 137 ALA A CB  1 
ATOM   777  N  N   . HIS A 1 138 ? 198.549 226.910 319.344 1.00 36.38 ? 138 HIS A N   1 
ATOM   778  C  CA  . HIS A 1 138 ? 198.200 228.060 318.532 1.00 36.38 ? 138 HIS A CA  1 
ATOM   779  C  C   . HIS A 1 138 ? 197.541 229.086 319.433 1.00 36.38 ? 138 HIS A C   1 
ATOM   780  O  O   . HIS A 1 138 ? 197.098 228.775 320.537 1.00 36.38 ? 138 HIS A O   1 
ATOM   781  C  CB  . HIS A 1 138 ? 197.283 227.681 317.376 1.00 36.38 ? 138 HIS A CB  1 
ATOM   782  C  CG  . HIS A 1 138 ? 197.159 228.747 316.337 1.00 36.38 ? 138 HIS A CG  1 
ATOM   783  N  ND1 . HIS A 1 138 ? 198.251 229.357 315.765 1.00 36.38 ? 138 HIS A ND1 1 
ATOM   784  C  CD2 . HIS A 1 138 ? 196.072 229.307 315.762 1.00 36.38 ? 138 HIS A CD2 1 
ATOM   785  C  CE1 . HIS A 1 138 ? 197.842 230.249 314.883 1.00 36.38 ? 138 HIS A CE1 1 
ATOM   786  N  NE2 . HIS A 1 138 ? 196.524 230.240 314.863 1.00 36.38 ? 138 HIS A NE2 1 
ATOM   787  N  N   . GLY A 1 139 ? 197.510 230.319 318.958 1.00 43.47 ? 139 GLY A N   1 
ATOM   788  C  CA  . GLY A 1 139 ? 196.898 231.399 319.692 1.00 43.47 ? 139 GLY A CA  1 
ATOM   789  C  C   . GLY A 1 139 ? 197.849 232.025 320.687 1.00 43.47 ? 139 GLY A C   1 
ATOM   790  O  O   . GLY A 1 139 ? 198.942 231.531 320.962 1.00 43.47 ? 139 GLY A O   1 
ATOM   791  N  N   . ARG A 1 140 ? 197.411 233.150 321.229 1.00 52.66 ? 140 ARG A N   1 
ATOM   792  C  CA  . ARG A 1 140 ? 198.159 233.921 322.206 1.00 52.66 ? 140 ARG A CA  1 
ATOM   793  C  C   . ARG A 1 140 ? 197.368 233.994 323.497 1.00 52.66 ? 140 ARG A C   1 
ATOM   794  O  O   . ARG A 1 140 ? 196.154 234.199 323.479 1.00 52.66 ? 140 ARG A O   1 
ATOM   795  C  CB  . ARG A 1 140 ? 198.456 235.324 321.685 1.00 52.66 ? 140 ARG A CB  1 
ATOM   796  C  CG  . ARG A 1 140 ? 198.964 235.351 320.261 1.00 52.66 ? 140 ARG A CG  1 
ATOM   797  C  CD  . ARG A 1 140 ? 199.067 236.756 319.734 1.00 52.66 ? 140 ARG A CD  1 
ATOM   798  N  NE  . ARG A 1 140 ? 199.859 237.618 320.600 1.00 52.66 ? 140 ARG A NE  1 
ATOM   799  C  CZ  . ARG A 1 140 ? 201.174 237.548 320.735 1.00 52.66 ? 140 ARG A CZ  1 
ATOM   800  N  NH1 . ARG A 1 140 ? 201.892 236.666 320.062 1.00 52.66 ? 140 ARG A NH1 1 
ATOM   801  N  NH2 . ARG A 1 140 ? 201.786 238.392 321.559 1.00 52.66 ? 140 ARG A NH2 1 
ATOM   802  N  N   . ILE A 1 141 ? 198.059 233.806 324.613 1.00 56.51 ? 141 ILE A N   1 
ATOM   803  C  CA  . ILE A 1 141 ? 197.429 233.736 325.922 1.00 56.51 ? 141 ILE A CA  1 
ATOM   804  C  C   . ILE A 1 141 ? 198.154 234.680 326.860 1.00 56.51 ? 141 ILE A C   1 
ATOM   805  O  O   . ILE A 1 141 ? 199.339 234.490 327.137 1.00 56.51 ? 141 ILE A O   1 
ATOM   806  C  CB  . ILE A 1 141 ? 197.468 232.308 326.478 1.00 56.51 ? 141 ILE A CB  1 
ATOM   807  C  CG1 . ILE A 1 141 ? 196.575 231.408 325.645 1.00 56.51 ? 141 ILE A CG1 1 
ATOM   808  C  CG2 . ILE A 1 141 ? 197.070 232.285 327.926 1.00 56.51 ? 141 ILE A CG2 1 
ATOM   809  C  CD1 . ILE A 1 141 ? 196.588 230.014 326.101 1.00 56.51 ? 141 ILE A CD1 1 
ATOM   810  N  N   . GLY A 1 142 ? 197.446 235.691 327.359 1.00 61.17 ? 142 GLY A N   1 
ATOM   811  C  CA  . GLY A 1 142 ? 198.045 236.662 328.251 1.00 61.17 ? 142 GLY A CA  1 
ATOM   812  C  C   . GLY A 1 142 ? 197.913 236.227 329.692 1.00 61.17 ? 142 GLY A C   1 
ATOM   813  O  O   . GLY A 1 142 ? 196.815 235.905 330.152 1.00 61.17 ? 142 GLY A O   1 
ATOM   814  N  N   . GLN A 1 143 ? 199.033 236.206 330.403 1.00 69.65 ? 143 GLN A N   1 
ATOM   815  C  CA  . GLN A 1 143 ? 199.035 235.795 331.801 1.00 69.65 ? 143 GLN A CA  1 
ATOM   816  C  C   . GLN A 1 143 ? 199.164 237.028 332.686 1.00 69.65 ? 143 GLN A C   1 
ATOM   817  O  O   . GLN A 1 143 ? 200.119 237.798 332.552 1.00 69.65 ? 143 GLN A O   1 
ATOM   818  C  CB  . GLN A 1 143 ? 200.156 234.802 332.090 1.00 69.65 ? 143 GLN A CB  1 
ATOM   819  C  CG  . GLN A 1 143 ? 201.434 235.099 331.374 1.00 69.65 ? 143 GLN A CG  1 
ATOM   820  C  CD  . GLN A 1 143 ? 202.367 233.924 331.388 1.00 69.65 ? 143 GLN A CD  1 
ATOM   821  O  OE1 . GLN A 1 143 ? 201.942 232.786 331.573 1.00 69.65 ? 143 GLN A OE1 1 
ATOM   822  N  NE2 . GLN A 1 143 ? 203.654 234.190 331.211 1.00 69.65 ? 143 GLN A NE2 1 
ATOM   823  N  N   . ALA A 1 144 ? 198.193 237.218 333.572 1.00 78.70 ? 144 ALA A N   1 
ATOM   824  C  CA  . ALA A 1 144 ? 198.179 238.319 334.525 1.00 78.70 ? 144 ALA A CA  1 
ATOM   825  C  C   . ALA A 1 144 ? 198.484 237.768 335.910 1.00 78.70 ? 144 ALA A C   1 
ATOM   826  O  O   . ALA A 1 144 ? 197.698 236.989 336.457 1.00 78.70 ? 144 ALA A O   1 
ATOM   827  C  CB  . ALA A 1 144 ? 196.827 239.027 334.515 1.00 78.70 ? 144 ALA A CB  1 
ATOM   828  N  N   . SER A 1 145 ? 199.612 238.178 336.476 1.00 83.60 ? 145 SER A N   1 
ATOM   829  C  CA  . SER A 1 145 ? 200.032 237.719 337.790 1.00 83.60 ? 145 SER A CA  1 
ATOM   830  C  C   . SER A 1 145 ? 199.429 238.611 338.872 1.00 83.60 ? 145 SER A C   1 
ATOM   831  O  O   . SER A 1 145 ? 198.565 239.450 338.610 1.00 83.60 ? 145 SER A O   1 
ATOM   832  C  CB  . SER A 1 145 ? 201.555 237.690 337.878 1.00 83.60 ? 145 SER A CB  1 
ATOM   833  O  OG  . SER A 1 145 ? 202.079 239.003 337.963 1.00 83.60 ? 145 SER A OG  1 
ATOM   834  N  N   . ALA A 1 146 ? 199.886 238.434 340.107 1.00 86.77 ? 146 ALA A N   1 
ATOM   835  C  CA  . ALA A 1 146 ? 199.396 239.225 341.230 1.00 86.77 ? 146 ALA A CA  1 
ATOM   836  C  C   . ALA A 1 146 ? 199.982 240.634 341.217 1.00 86.77 ? 146 ALA A C   1 
ATOM   837  O  O   . ALA A 1 146 ? 201.194 240.815 341.328 1.00 86.77 ? 146 ALA A O   1 
ATOM   838  C  CB  . ALA A 1 146 ? 199.719 238.531 342.542 1.00 86.77 ? 146 ALA A CB  1 
ATOM   839  N  N   . VAL A 1 153 ? 199.631 242.345 337.917 1.00 84.62 ? 153 VAL A N   1 
ATOM   840  C  CA  . VAL A 1 153 ? 200.770 242.609 337.052 1.00 84.62 ? 153 VAL A CA  1 
ATOM   841  C  C   . VAL A 1 153 ? 200.775 241.624 335.889 1.00 84.62 ? 153 VAL A C   1 
ATOM   842  O  O   . VAL A 1 153 ? 201.233 240.488 336.028 1.00 84.62 ? 153 VAL A O   1 
ATOM   843  C  CB  . VAL A 1 153 ? 202.086 242.530 337.839 1.00 84.62 ? 153 VAL A CB  1 
ATOM   844  C  CG1 . VAL A 1 153 ? 203.258 242.956 336.966 1.00 84.62 ? 153 VAL A CG1 1 
ATOM   845  C  CG2 . VAL A 1 153 ? 202.001 243.378 339.093 1.00 84.62 ? 153 VAL A CG2 1 
ATOM   846  N  N   . THR A 1 154 ? 200.283 242.068 334.734 1.00 82.23 ? 154 THR A N   1 
ATOM   847  C  CA  . THR A 1 154 ? 200.252 241.223 333.545 1.00 82.23 ? 154 THR A CA  1 
ATOM   848  C  C   . THR A 1 154 ? 201.675 240.971 333.067 1.00 82.23 ? 154 THR A C   1 
ATOM   849  O  O   . THR A 1 154 ? 202.316 241.863 332.503 1.00 82.23 ? 154 THR A O   1 
ATOM   850  C  CB  . THR A 1 154 ? 199.419 241.884 332.451 1.00 82.23 ? 154 THR A CB  1 
ATOM   851  O  OG1 . THR A 1 154 ? 198.131 242.229 332.974 1.00 82.23 ? 154 THR A OG1 1 
ATOM   852  C  CG2 . THR A 1 154 ? 199.246 240.946 331.274 1.00 82.23 ? 154 THR A CG2 1 
ATOM   853  N  N   . LEU A 1 155 ? 202.170 239.756 333.291 1.00 77.40 ? 155 LEU A N   1 
ATOM   854  C  CA  . LEU A 1 155 ? 203.552 239.438 332.958 1.00 77.40 ? 155 LEU A CA  1 
ATOM   855  C  C   . LEU A 1 155 ? 203.831 239.544 331.465 1.00 77.40 ? 155 LEU A C   1 
ATOM   856  O  O   . LEU A 1 155 ? 204.556 240.444 331.032 1.00 77.40 ? 155 LEU A O   1 
ATOM   857  C  CB  . LEU A 1 155 ? 203.900 238.032 333.440 1.00 77.40 ? 155 LEU A CB  1 
ATOM   858  C  CG  . LEU A 1 155 ? 203.915 237.820 334.948 1.00 77.40 ? 155 LEU A CG  1 
ATOM   859  C  CD1 . LEU A 1 155 ? 204.624 236.517 335.290 1.00 77.40 ? 155 LEU A CD1 1 
ATOM   860  C  CD2 . LEU A 1 155 ? 204.566 239.006 335.652 1.00 77.40 ? 155 LEU A CD2 1 
ATOM   861  N  N   . ASP A 1 156 ? 203.227 238.667 330.669 1.00 70.46 ? 156 ASP A N   1 
ATOM   862  C  CA  . ASP A 1 156 ? 203.497 238.638 329.237 1.00 70.46 ? 156 ASP A CA  1 
ATOM   863  C  C   . ASP A 1 156 ? 202.397 237.847 328.539 1.00 70.46 ? 156 ASP A C   1 
ATOM   864  O  O   . ASP A 1 156 ? 201.348 237.552 329.125 1.00 70.46 ? 156 ASP A O   1 
ATOM   865  C  CB  . ASP A 1 156 ? 204.884 238.055 328.943 1.00 70.46 ? 156 ASP A CB  1 
ATOM   866  C  CG  . ASP A 1 156 ? 205.264 236.949 329.894 1.00 70.46 ? 156 ASP A CG  1 
ATOM   867  O  OD1 . ASP A 1 156 ? 204.361 236.231 330.360 1.00 70.46 ? 156 ASP A OD1 1 
ATOM   868  O  OD2 . ASP A 1 156 ? 206.467 236.801 330.177 1.00 70.46 ? 156 ASP A OD2 1 
ATOM   869  N  N   . VAL A 1 157 ? 202.635 237.534 327.267 1.00 58.99 ? 157 VAL A N   1 
ATOM   870  C  CA  . VAL A 1 157 ? 201.706 236.802 326.426 1.00 58.99 ? 157 VAL A CA  1 
ATOM   871  C  C   . VAL A 1 157 ? 202.444 235.626 325.814 1.00 58.99 ? 157 VAL A C   1 
ATOM   872  O  O   . VAL A 1 157 ? 203.397 235.816 325.046 1.00 58.99 ? 157 VAL A O   1 
ATOM   873  C  CB  . VAL A 1 157 ? 201.104 237.693 325.330 1.00 58.99 ? 157 VAL A CB  1 
ATOM   874  C  CG1 . VAL A 1 157 ? 200.178 236.897 324.459 1.00 58.99 ? 157 VAL A CG1 1 
ATOM   875  C  CG2 . VAL A 1 157 ? 200.376 238.872 325.949 1.00 58.99 ? 157 VAL A CG2 1 
ATOM   876  N  N   . LEU A 1 158 ? 201.996 234.418 326.149 1.00 53.09 ? 158 LEU A N   1 
ATOM   877  C  CA  . LEU A 1 158 ? 202.512 233.203 325.550 1.00 53.09 ? 158 LEU A CA  1 
ATOM   878  C  C   . LEU A 1 158 ? 201.931 233.002 324.156 1.00 53.09 ? 158 LEU A C   1 
ATOM   879  O  O   . LEU A 1 158 ? 200.836 233.470 323.831 1.00 53.09 ? 158 LEU A O   1 
ATOM   880  C  CB  . LEU A 1 158 ? 202.179 232.001 326.428 1.00 53.09 ? 158 LEU A CB  1 
ATOM   881  C  CG  . LEU A 1 158 ? 202.549 232.190 327.889 1.00 53.09 ? 158 LEU A CG  1 
ATOM   882  C  CD1 . LEU A 1 158 ? 202.341 230.905 328.643 1.00 53.09 ? 158 LEU A CD1 1 
ATOM   883  C  CD2 . LEU A 1 158 ? 204.003 232.621 328.000 1.00 53.09 ? 158 LEU A CD2 1 
ATOM   884  N  N   . ALA A 1 159 ? 202.665 232.262 323.339 1.00 46.72 ? 159 ALA A N   1 
ATOM   885  C  CA  . ALA A 1 159 ? 202.299 232.065 321.956 1.00 46.72 ? 159 ALA A CA  1 
ATOM   886  C  C   . ALA A 1 159 ? 202.536 230.609 321.596 1.00 46.72 ? 159 ALA A C   1 
ATOM   887  O  O   . ALA A 1 159 ? 202.704 229.754 322.467 1.00 46.72 ? 159 ALA A O   1 
ATOM   888  C  CB  . ALA A 1 159 ? 203.075 233.004 321.033 1.00 46.72 ? 159 ALA A CB  1 
ATOM   889  N  N   . ASP A 1 160 ? 202.538 230.327 320.297 1.00 44.01 ? 160 ASP A N   1 
ATOM   890  C  CA  . ASP A 1 160 ? 202.711 228.968 319.835 1.00 44.01 ? 160 ASP A CA  1 
ATOM   891  C  C   . ASP A 1 160 ? 204.023 228.400 320.330 1.00 44.01 ? 160 ASP A C   1 
ATOM   892  O  O   . ASP A 1 160 ? 205.071 229.032 320.223 1.00 44.01 ? 160 ASP A O   1 
ATOM   893  C  CB  . ASP A 1 160 ? 202.675 228.917 318.317 1.00 44.01 ? 160 ASP A CB  1 
ATOM   894  C  CG  . ASP A 1 160 ? 201.568 229.770 317.726 1.00 44.01 ? 160 ASP A CG  1 
ATOM   895  O  OD1 . ASP A 1 160 ? 200.701 230.175 318.499 1.00 44.01 ? 160 ASP A OD1 1 
ATOM   896  O  OD2 . ASP A 1 160 ? 201.528 229.988 316.512 1.00 44.01 ? 160 ASP A OD2 1 
ATOM   897  N  N   . GLY A 1 161 ? 203.963 227.189 320.843 1.00 46.57 ? 161 GLY A N   1 
ATOM   898  C  CA  . GLY A 1 161 ? 205.146 226.555 321.350 1.00 46.57 ? 161 GLY A CA  1 
ATOM   899  C  C   . GLY A 1 161 ? 205.522 226.879 322.778 1.00 46.57 ? 161 GLY A C   1 
ATOM   900  O  O   . GLY A 1 161 ? 206.549 226.390 323.255 1.00 46.57 ? 161 GLY A O   1 
ATOM   901  N  N   . ASP A 1 162 ? 204.743 227.679 323.470 1.00 48.66 ? 162 ASP A N   1 
ATOM   902  C  CA  . ASP A 1 162 ? 205.034 228.026 324.844 1.00 48.66 ? 162 ASP A CA  1 
ATOM   903  C  C   . ASP A 1 162 ? 204.400 227.011 325.782 1.00 48.66 ? 162 ASP A C   1 
ATOM   904  O  O   . ASP A 1 162 ? 203.489 226.271 325.415 1.00 48.66 ? 162 ASP A O   1 
ATOM   905  C  CB  . ASP A 1 162 ? 204.538 229.431 325.143 1.00 48.66 ? 162 ASP A CB  1 
ATOM   906  C  CG  . ASP A 1 162 ? 205.451 230.492 324.579 1.00 48.66 ? 162 ASP A CG  1 
ATOM   907  O  OD1 . ASP A 1 162 ? 206.680 230.338 324.684 1.00 48.66 ? 162 ASP A OD1 1 
ATOM   908  O  OD2 . ASP A 1 162 ? 204.937 231.489 324.026 1.00 48.66 ? 162 ASP A OD2 1 
ATOM   909  N  N   . ARG A 1 163 ? 204.904 226.977 327.006 1.00 54.87 ? 163 ARG A N   1 
ATOM   910  C  CA  . ARG A 1 163 ? 204.428 226.052 328.019 1.00 54.87 ? 163 ARG A CA  1 
ATOM   911  C  C   . ARG A 1 163 ? 204.185 226.800 329.311 1.00 54.87 ? 163 ARG A C   1 
ATOM   912  O  O   . ARG A 1 163 ? 204.916 227.733 329.648 1.00 54.87 ? 163 ARG A O   1 
ATOM   913  C  CB  . ARG A 1 163 ? 205.426 224.939 328.291 1.00 54.87 ? 163 ARG A CB  1 
ATOM   914  C  CG  . ARG A 1 163 ? 206.408 224.728 327.177 1.00 54.87 ? 163 ARG A CG  1 
ATOM   915  C  CD  . ARG A 1 163 ? 207.627 223.958 327.607 1.00 54.87 ? 163 ARG A CD  1 
ATOM   916  N  NE  . ARG A 1 163 ? 208.560 224.787 328.354 1.00 54.87 ? 163 ARG A NE  1 
ATOM   917  C  CZ  . ARG A 1 163 ? 209.714 224.352 328.838 1.00 54.87 ? 163 ARG A CZ  1 
ATOM   918  N  NH1 . ARG A 1 163 ? 210.101 223.102 328.671 1.00 54.87 ? 163 ARG A NH1 1 
ATOM   919  N  NH2 . ARG A 1 163 ? 210.505 225.196 329.492 1.00 54.87 ? 163 ARG A NH2 1 
ATOM   920  N  N   . PHE A 1 164 ? 203.138 226.406 330.020 1.00 57.34 ? 164 PHE A N   1 
ATOM   921  C  CA  . PHE A 1 164 ? 202.920 226.879 331.374 1.00 57.34 ? 164 PHE A CA  1 
ATOM   922  C  C   . PHE A 1 164 ? 202.182 225.798 332.139 1.00 57.34 ? 164 PHE A C   1 
ATOM   923  O  O   . PHE A 1 164 ? 201.231 225.207 331.625 1.00 57.34 ? 164 PHE A O   1 
ATOM   924  C  CB  . PHE A 1 164 ? 202.177 228.213 331.405 1.00 57.34 ? 164 PHE A CB  1 
ATOM   925  C  CG  . PHE A 1 164 ? 200.731 228.126 331.048 1.00 57.34 ? 164 PHE A CG  1 
ATOM   926  C  CD1 . PHE A 1 164 ? 200.333 228.159 329.729 1.00 57.34 ? 164 PHE A CD1 1 
ATOM   927  C  CD2 . PHE A 1 164 ? 199.769 228.047 332.026 1.00 57.34 ? 164 PHE A CD2 1 
ATOM   928  C  CE1 . PHE A 1 164 ? 199.005 228.101 329.394 1.00 57.34 ? 164 PHE A CE1 1 
ATOM   929  C  CE2 . PHE A 1 164 ? 198.436 227.988 331.693 1.00 57.34 ? 164 PHE A CE2 1 
ATOM   930  C  CZ  . PHE A 1 164 ? 198.055 228.016 330.375 1.00 57.34 ? 164 PHE A CZ  1 
ATOM   931  N  N   . GLY A 1 165 ? 202.614 225.556 333.364 1.00 65.70 ? 165 GLY A N   1 
ATOM   932  C  CA  . GLY A 1 165 ? 202.186 224.409 334.126 1.00 65.70 ? 165 GLY A CA  1 
ATOM   933  C  C   . GLY A 1 165 ? 203.243 223.357 334.338 1.00 65.70 ? 165 GLY A C   1 
ATOM   934  O  O   . GLY A 1 165 ? 202.893 222.207 334.600 1.00 65.70 ? 165 GLY A O   1 
ATOM   935  N  N   . GLU A 1 166 ? 204.520 223.723 334.264 1.00 72.08 ? 166 GLU A N   1 
ATOM   936  C  CA  . GLU A 1 166 ? 205.618 222.777 334.422 1.00 72.08 ? 166 GLU A CA  1 
ATOM   937  C  C   . GLU A 1 166 ? 205.585 222.117 335.794 1.00 72.08 ? 166 GLU A C   1 
ATOM   938  O  O   . GLU A 1 166 ? 205.421 220.899 335.915 1.00 72.08 ? 166 GLU A O   1 
ATOM   939  C  CB  . GLU A 1 166 ? 206.940 223.515 334.220 1.00 72.08 ? 166 GLU A CB  1 
ATOM   940  C  CG  . GLU A 1 166 ? 207.579 223.397 332.862 1.00 72.08 ? 166 GLU A CG  1 
ATOM   941  C  CD  . GLU A 1 166 ? 208.222 222.051 332.639 1.00 72.08 ? 166 GLU A CD  1 
ATOM   942  O  OE1 . GLU A 1 166 ? 208.175 221.203 333.549 1.00 72.08 ? 166 GLU A OE1 1 
ATOM   943  O  OE2 . GLU A 1 166 ? 208.817 221.857 331.564 1.00 72.08 ? 166 GLU A OE2 1 
ATOM   944  N  N   . HIS A 1 167 ? 205.711 222.925 336.847 1.00 78.89 ? 167 HIS A N   1 
ATOM   945  C  CA  . HIS A 1 167 ? 205.847 222.427 338.210 1.00 78.89 ? 167 HIS A CA  1 
ATOM   946  C  C   . HIS A 1 167 ? 204.656 221.592 338.637 1.00 78.89 ? 167 HIS A C   1 
ATOM   947  O  O   . HIS A 1 167 ? 204.786 220.759 339.536 1.00 78.89 ? 167 HIS A O   1 
ATOM   948  C  CB  . HIS A 1 167 ? 206.023 223.587 339.184 1.00 78.89 ? 167 HIS A CB  1 
ATOM   949  C  CG  . HIS A 1 167 ? 204.945 224.618 339.092 1.00 78.89 ? 167 HIS A CG  1 
ATOM   950  N  ND1 . HIS A 1 167 ? 204.840 225.487 338.030 1.00 78.89 ? 167 HIS A ND1 1 
ATOM   951  C  CD2 . HIS A 1 167 ? 203.929 224.924 339.932 1.00 78.89 ? 167 HIS A CD2 1 
ATOM   952  C  CE1 . HIS A 1 167 ? 203.803 226.283 338.217 1.00 78.89 ? 167 HIS A CE1 1 
ATOM   953  N  NE2 . HIS A 1 167 ? 203.233 225.962 339.364 1.00 78.89 ? 167 HIS A NE2 1 
ATOM   954  N  N   . ALA A 1 168 ? 203.508 221.781 338.001 1.00 76.64 ? 168 ALA A N   1 
ATOM   955  C  CA  . ALA A 1 168 ? 202.323 221.014 338.346 1.00 76.64 ? 168 ALA A CA  1 
ATOM   956  C  C   . ALA A 1 168 ? 202.535 219.527 338.117 1.00 76.64 ? 168 ALA A C   1 
ATOM   957  O  O   . ALA A 1 168 ? 201.829 218.717 338.722 1.00 76.64 ? 168 ALA A O   1 
ATOM   958  C  CB  . ALA A 1 168 ? 201.118 221.509 337.546 1.00 76.64 ? 168 ALA A CB  1 
ATOM   959  N  N   . LEU A 1 169 ? 203.487 219.144 337.264 1.00 75.19 ? 169 LEU A N   1 
ATOM   960  C  CA  . LEU A 1 169 ? 203.659 217.727 336.956 1.00 75.19 ? 169 LEU A CA  1 
ATOM   961  C  C   . LEU A 1 169 ? 204.240 216.950 338.134 1.00 75.19 ? 169 LEU A C   1 
ATOM   962  O  O   . LEU A 1 169 ? 203.790 215.835 338.424 1.00 75.19 ? 169 LEU A O   1 
ATOM   963  C  CB  . LEU A 1 169 ? 204.544 217.578 335.725 1.00 75.19 ? 169 LEU A CB  1 
ATOM   964  C  CG  . LEU A 1 169 ? 203.767 217.598 334.410 1.00 75.19 ? 169 LEU A CG  1 
ATOM   965  C  CD1 . LEU A 1 169 ? 204.694 217.587 333.212 1.00 75.19 ? 169 LEU A CD1 1 
ATOM   966  C  CD2 . LEU A 1 169 ? 202.780 216.467 334.350 1.00 75.19 ? 169 LEU A CD2 1 
ATOM   967  N  N   . LEU A 1 170 ? 205.234 217.507 338.827 1.00 80.20 ? 170 LEU A N   1 
ATOM   968  C  CA  . LEU A 1 170 ? 205.942 216.744 339.860 1.00 80.20 ? 170 LEU A CA  1 
ATOM   969  C  C   . LEU A 1 170 ? 205.200 216.759 341.193 1.00 80.20 ? 170 LEU A C   1 
ATOM   970  O  O   . LEU A 1 170 ? 204.784 215.711 341.707 1.00 80.20 ? 170 LEU A O   1 
ATOM   971  C  CB  . LEU A 1 170 ? 207.368 217.275 340.075 1.00 80.20 ? 170 LEU A CB  1 
ATOM   972  C  CG  . LEU A 1 170 ? 208.493 216.577 339.317 1.00 80.20 ? 170 LEU A CG  1 
ATOM   973  C  CD1 . LEU A 1 170 ? 209.841 217.119 339.693 1.00 80.20 ? 170 LEU A CD1 1 
ATOM   974  C  CD2 . LEU A 1 170 ? 208.457 215.086 339.575 1.00 80.20 ? 170 LEU A CD2 1 
ATOM   975  N  N   . ASP A 1 171 ? 205.019 217.940 341.765 1.00 85.17 ? 171 ASP A N   1 
ATOM   976  C  CA  . ASP A 1 171 ? 204.478 218.080 343.107 1.00 85.17 ? 171 ASP A CA  1 
ATOM   977  C  C   . ASP A 1 171 ? 202.996 218.427 343.078 1.00 85.17 ? 171 ASP A C   1 
ATOM   978  O  O   . ASP A 1 171 ? 202.461 218.950 342.096 1.00 85.17 ? 171 ASP A O   1 
ATOM   979  C  CB  . ASP A 1 171 ? 205.250 219.149 343.893 1.00 85.17 ? 171 ASP A CB  1 
ATOM   980  C  CG  . ASP A 1 171 ? 204.868 220.550 343.492 1.00 85.17 ? 171 ASP A CG  1 
ATOM   981  O  OD1 . ASP A 1 171 ? 204.636 220.784 342.293 1.00 85.17 ? 171 ASP A OD1 1 
ATOM   982  O  OD2 . ASP A 1 171 ? 204.811 221.424 344.380 1.00 85.17 ? 171 ASP A OD2 1 
ATOM   983  N  N   . GLU A 1 172 ? 202.338 218.111 344.188 1.00 87.00 ? 172 GLU A N   1 
ATOM   984  C  CA  . GLU A 1 172 ? 200.920 218.344 344.388 1.00 87.00 ? 172 GLU A CA  1 
ATOM   985  C  C   . GLU A 1 172 ? 200.642 219.685 345.047 1.00 87.00 ? 172 GLU A C   1 
ATOM   986  O  O   . GLU A 1 172 ? 199.476 220.058 345.209 1.00 87.00 ? 172 GLU A O   1 
ATOM   987  C  CB  . GLU A 1 172 ? 200.345 217.205 345.234 1.00 87.00 ? 172 GLU A CB  1 
ATOM   988  C  CG  . GLU A 1 172 ? 200.380 215.842 344.540 1.00 87.00 ? 172 GLU A CG  1 
ATOM   989  C  CD  . GLU A 1 172 ? 201.691 215.093 344.754 1.00 87.00 ? 172 GLU A CD  1 
ATOM   990  O  OE1 . GLU A 1 172 ? 202.765 215.727 344.692 1.00 87.00 ? 172 GLU A OE1 1 
ATOM   991  O  OE2 . GLU A 1 172 ? 201.647 213.866 344.984 1.00 87.00 ? 172 GLU A OE2 1 
ATOM   992  N  N   . ASP A 1 173 ? 201.689 220.413 345.429 1.00 88.42 ? 173 ASP A N   1 
ATOM   993  C  CA  . ASP A 1 173 ? 201.528 221.702 346.080 1.00 88.42 ? 173 ASP A CA  1 
ATOM   994  C  C   . ASP A 1 173 ? 201.312 222.793 345.038 1.00 88.42 ? 173 ASP A C   1 
ATOM   995  O  O   . ASP A 1 173 ? 200.914 223.908 345.384 1.00 88.42 ? 173 ASP A O   1 
ATOM   996  C  CB  . ASP A 1 173 ? 202.778 221.948 346.949 1.00 88.42 ? 173 ASP A CB  1 
ATOM   997  C  CG  . ASP A 1 173 ? 202.784 223.292 347.700 1.00 88.42 ? 173 ASP A CG  1 
ATOM   998  O  OD1 . ASP A 1 173 ? 203.764 223.531 348.435 1.00 88.42 ? 173 ASP A OD1 1 
ATOM   999  O  OD2 . ASP A 1 173 ? 201.841 224.100 347.623 1.00 88.42 ? 173 ASP A OD2 1 
ATOM   1000 N  N   . ALA A 1 174 ? 201.479 222.460 343.759 1.00 84.32 ? 174 ALA A N   1 
ATOM   1001 C  CA  . ALA A 1 174 ? 201.446 223.466 342.711 1.00 84.32 ? 174 ALA A CA  1 
ATOM   1002 C  C   . ALA A 1 174 ? 200.122 224.210 342.712 1.00 84.32 ? 174 ALA A C   1 
ATOM   1003 O  O   . ALA A 1 174 ? 199.049 223.611 342.809 1.00 84.32 ? 174 ALA A O   1 
ATOM   1004 C  CB  . ALA A 1 174 ? 201.669 222.817 341.350 1.00 84.32 ? 174 ALA A CB  1 
ATOM   1005 N  N   . ARG A 1 175 ? 200.211 225.526 342.595 1.00 81.55 ? 175 ARG A N   1 
ATOM   1006 C  CA  . ARG A 1 175 ? 199.058 226.401 342.645 1.00 81.55 ? 175 ARG A CA  1 
ATOM   1007 C  C   . ARG A 1 175 ? 199.193 227.447 341.554 1.00 81.55 ? 175 ARG A C   1 
ATOM   1008 O  O   . ARG A 1 175 ? 200.285 227.971 341.325 1.00 81.55 ? 175 ARG A O   1 
ATOM   1009 C  CB  . ARG A 1 175 ? 198.941 227.060 344.019 1.00 81.55 ? 175 ARG A CB  1 
ATOM   1010 C  CG  . ARG A 1 175 ? 197.997 228.239 344.077 1.00 81.55 ? 175 ARG A CG  1 
ATOM   1011 C  CD  . ARG A 1 175 ? 197.381 228.394 345.457 1.00 81.55 ? 175 ARG A CD  1 
ATOM   1012 N  NE  . ARG A 1 175 ? 196.241 227.507 345.643 1.00 81.55 ? 175 ARG A NE  1 
ATOM   1013 C  CZ  . ARG A 1 175 ? 196.308 226.313 346.212 1.00 81.55 ? 175 ARG A CZ  1 
ATOM   1014 N  NH1 . ARG A 1 175 ? 197.451 225.828 346.665 1.00 81.55 ? 175 ARG A NH1 1 
ATOM   1015 N  NH2 . ARG A 1 175 ? 195.203 225.581 346.315 1.00 81.55 ? 175 ARG A NH2 1 
ATOM   1016 N  N   . TRP A 1 176 ? 198.091 227.737 340.876 1.00 79.03 ? 176 TRP A N   1 
ATOM   1017 C  CA  . TRP A 1 176 ? 198.108 228.751 339.834 1.00 79.03 ? 176 TRP A CA  1 
ATOM   1018 C  C   . TRP A 1 176 ? 198.255 230.126 340.465 1.00 79.03 ? 176 TRP A C   1 
ATOM   1019 O  O   . TRP A 1 176 ? 197.410 230.544 341.263 1.00 79.03 ? 176 TRP A O   1 
ATOM   1020 C  CB  . TRP A 1 176 ? 196.844 228.691 338.987 1.00 79.03 ? 176 TRP A CB  1 
ATOM   1021 C  CG  . TRP A 1 176 ? 196.750 227.493 338.131 1.00 79.03 ? 176 TRP A CG  1 
ATOM   1022 C  CD1 . TRP A 1 176 ? 195.736 226.592 338.099 1.00 79.03 ? 176 TRP A CD1 1 
ATOM   1023 C  CD2 . TRP A 1 176 ? 197.711 227.052 337.170 1.00 79.03 ? 176 TRP A CD2 1 
ATOM   1024 N  NE1 . TRP A 1 176 ? 196.001 225.617 337.174 1.00 79.03 ? 176 TRP A NE1 1 
ATOM   1025 C  CE2 . TRP A 1 176 ? 197.211 225.879 336.591 1.00 79.03 ? 176 TRP A CE2 1 
ATOM   1026 C  CE3 . TRP A 1 176 ? 198.948 227.538 336.743 1.00 79.03 ? 176 TRP A CE3 1 
ATOM   1027 C  CZ2 . TRP A 1 176 ? 197.902 225.184 335.609 1.00 79.03 ? 176 TRP A CZ2 1 
ATOM   1028 C  CZ3 . TRP A 1 176 ? 199.631 226.845 335.771 1.00 79.03 ? 176 TRP A CZ3 1 
ATOM   1029 C  CH2 . TRP A 1 176 ? 199.108 225.684 335.213 1.00 79.03 ? 176 TRP A CH2 1 
ATOM   1030 N  N   . SER A 1 177 ? 199.334 230.820 340.127 1.00 78.40 ? 177 SER A N   1 
ATOM   1031 C  CA  . SER A 1 177 ? 199.571 232.163 340.624 1.00 78.40 ? 177 SER A CA  1 
ATOM   1032 C  C   . SER A 1 177 ? 199.316 233.234 339.572 1.00 78.40 ? 177 SER A C   1 
ATOM   1033 O  O   . SER A 1 177 ? 199.401 234.425 339.886 1.00 78.40 ? 177 SER A O   1 
ATOM   1034 C  CB  . SER A 1 177 ? 201.000 232.272 341.159 1.00 78.40 ? 177 SER A CB  1 
ATOM   1035 O  OG  . SER A 1 177 ? 201.938 232.029 340.133 1.00 78.40 ? 177 SER A OG  1 
ATOM   1036 N  N   . GLN A 1 178 ? 198.911 232.805 338.380 1.00 77.35 ? 178 GLN A N   1 
ATOM   1037 C  CA  . GLN A 1 178 ? 198.591 233.734 337.312 1.00 77.35 ? 178 GLN A CA  1 
ATOM   1038 C  C   . GLN A 1 178 ? 197.285 233.354 336.654 1.00 77.35 ? 178 GLN A C   1 
ATOM   1039 O  O   . GLN A 1 178 ? 196.917 232.186 336.637 1.00 77.35 ? 178 GLN A O   1 
ATOM   1040 C  CB  . GLN A 1 178 ? 199.686 233.726 336.257 1.00 77.35 ? 178 GLN A CB  1 
ATOM   1041 C  CG  . GLN A 1 178 ? 199.757 232.458 335.432 1.00 77.35 ? 178 GLN A CG  1 
ATOM   1042 C  CD  . GLN A 1 178 ? 200.366 231.309 336.204 1.00 77.35 ? 178 GLN A CD  1 
ATOM   1043 O  OE1 . GLN A 1 178 ? 200.740 231.453 337.367 1.00 77.35 ? 178 GLN A OE1 1 
ATOM   1044 N  NE2 . GLN A 1 178 ? 200.456 230.152 335.562 1.00 77.35 ? 178 GLN A NE2 1 
ATOM   1045 N  N   . THR A 1 179 ? 196.575 234.327 336.118 1.00 73.27 ? 179 THR A N   1 
ATOM   1046 C  CA  . THR A 1 179 ? 195.337 234.077 335.398 1.00 73.27 ? 179 THR A CA  1 
ATOM   1047 C  C   . THR A 1 179 ? 195.613 234.171 333.905 1.00 73.27 ? 179 THR A C   1 
ATOM   1048 O  O   . THR A 1 179 ? 196.139 235.182 333.434 1.00 73.27 ? 179 THR A O   1 
ATOM   1049 C  CB  . THR A 1 179 ? 194.257 235.072 335.807 1.00 73.27 ? 179 THR A CB  1 
ATOM   1050 O  OG1 . THR A 1 179 ? 193.821 234.777 337.138 1.00 73.27 ? 179 THR A OG1 1 
ATOM   1051 C  CG2 . THR A 1 179 ? 193.076 234.981 334.862 1.00 73.27 ? 179 THR A CG2 1 
ATOM   1052 N  N   . ALA A 1 180 ? 195.283 233.116 333.173 1.00 66.34 ? 180 ALA A N   1 
ATOM   1053 C  CA  . ALA A 1 180 ? 195.561 233.036 331.745 1.00 66.34 ? 180 ALA A CA  1 
ATOM   1054 C  C   . ALA A 1 180 ? 194.290 233.347 330.971 1.00 66.34 ? 180 ALA A C   1 
ATOM   1055 O  O   . ALA A 1 180 ? 193.341 232.562 330.983 1.00 66.34 ? 180 ALA A O   1 
ATOM   1056 C  CB  . ALA A 1 180 ? 196.096 231.657 331.381 1.00 66.34 ? 180 ALA A CB  1 
ATOM   1057 N  N   . THR A 1 181 ? 194.280 234.482 330.284 1.00 62.05 ? 181 THR A N   1 
ATOM   1058 C  CA  . THR A 1 181 ? 193.163 234.898 329.452 1.00 62.05 ? 181 THR A CA  1 
ATOM   1059 C  C   . THR A 1 181 ? 193.544 234.735 327.990 1.00 62.05 ? 181 THR A C   1 
ATOM   1060 O  O   . THR A 1 181 ? 194.578 235.248 327.552 1.00 62.05 ? 181 THR A O   1 
ATOM   1061 C  CB  . THR A 1 181 ? 192.780 236.347 329.741 1.00 62.05 ? 181 THR A CB  1 
ATOM   1062 O  OG1 . THR A 1 181 ? 193.962 237.108 330.019 1.00 62.05 ? 181 THR A OG1 1 
ATOM   1063 C  CG2 . THR A 1 181 ? 191.851 236.414 330.937 1.00 62.05 ? 181 THR A CG2 1 
ATOM   1064 N  N   . ALA A 1 182 ? 192.704 234.041 327.237 1.00 57.37 ? 182 ALA A N   1 
ATOM   1065 C  CA  . ALA A 1 182 ? 192.987 233.762 325.837 1.00 57.37 ? 182 ALA A CA  1 
ATOM   1066 C  C   . ALA A 1 182 ? 192.645 234.983 325.000 1.00 57.37 ? 182 ALA A C   1 
ATOM   1067 O  O   . ALA A 1 182 ? 191.470 235.303 324.806 1.00 57.37 ? 182 ALA A O   1 
ATOM   1068 C  CB  . ALA A 1 182 ? 192.194 232.546 325.378 1.00 57.37 ? 182 ALA A CB  1 
ATOM   1069 N  N   . GLU A 1 183 ? 193.672 235.669 324.501 1.00 58.08 ? 183 GLU A N   1 
ATOM   1070 C  CA  . GLU A 1 183 ? 193.437 236.822 323.642 1.00 58.08 ? 183 GLU A CA  1 
ATOM   1071 C  C   . GLU A 1 183 ? 192.995 236.409 322.248 1.00 58.08 ? 183 GLU A C   1 
ATOM   1072 O  O   . GLU A 1 183 ? 192.277 237.159 321.582 1.00 58.08 ? 183 GLU A O   1 
ATOM   1073 C  CB  . GLU A 1 183 ? 194.699 237.667 323.548 1.00 58.08 ? 183 GLU A CB  1 
ATOM   1074 C  CG  . GLU A 1 183 ? 195.325 237.968 324.883 1.00 58.08 ? 183 GLU A CG  1 
ATOM   1075 C  CD  . GLU A 1 183 ? 196.659 238.662 324.744 1.00 58.08 ? 183 GLU A CD  1 
ATOM   1076 O  OE1 . GLU A 1 183 ? 197.142 238.796 323.601 1.00 58.08 ? 183 GLU A OE1 1 
ATOM   1077 O  OE2 . GLU A 1 183 ? 197.221 239.077 325.777 1.00 58.08 ? 183 GLU A OE2 1 
ATOM   1078 N  N   . THR A 1 184 ? 193.420 235.238 321.787 1.00 51.99 ? 184 THR A N   1 
ATOM   1079 C  CA  . THR A 1 184 ? 193.080 234.746 320.463 1.00 51.99 ? 184 THR A CA  1 
ATOM   1080 C  C   . THR A 1 184 ? 192.660 233.290 320.544 1.00 51.99 ? 184 THR A C   1 
ATOM   1081 O  O   . THR A 1 184 ? 193.150 232.533 321.382 1.00 51.99 ? 184 THR A O   1 
ATOM   1082 C  CB  . THR A 1 184 ? 194.257 234.888 319.499 1.00 51.99 ? 184 THR A CB  1 
ATOM   1083 O  OG1 . THR A 1 184 ? 194.866 236.170 319.680 1.00 51.99 ? 184 THR A OG1 1 
ATOM   1084 C  CG2 . THR A 1 184 ? 193.795 234.760 318.069 1.00 51.99 ? 184 THR A CG2 1 
ATOM   1085 N  N   . SER A 1 185 ? 191.730 232.909 319.680 1.00 49.22 ? 185 SER A N   1 
ATOM   1086 C  CA  . SER A 1 185 ? 191.297 231.524 319.618 1.00 49.22 ? 185 SER A CA  1 
ATOM   1087 C  C   . SER A 1 185 ? 192.441 230.625 319.170 1.00 49.22 ? 185 SER A C   1 
ATOM   1088 O  O   . SER A 1 185 ? 193.246 230.999 318.317 1.00 49.22 ? 185 SER A O   1 
ATOM   1089 C  CB  . SER A 1 185 ? 190.120 231.407 318.652 1.00 49.22 ? 185 SER A CB  1 
ATOM   1090 O  OG  . SER A 1 185 ? 189.924 230.077 318.221 1.00 49.22 ? 185 SER A OG  1 
ATOM   1091 N  N   . GLY A 1 186 ? 192.509 229.432 319.746 1.00 46.57 ? 186 GLY A N   1 
ATOM   1092 C  CA  . GLY A 1 186 ? 193.577 228.513 319.410 1.00 46.57 ? 186 GLY A CA  1 
ATOM   1093 C  C   . GLY A 1 186 ? 193.377 227.174 320.082 1.00 46.57 ? 186 GLY A C   1 
ATOM   1094 O  O   . GLY A 1 186 ? 192.336 226.912 320.678 1.00 46.57 ? 186 GLY A O   1 
ATOM   1095 N  N   . THR A 1 187 ? 194.377 226.309 319.939 1.00 41.76 ? 187 THR A N   1 
ATOM   1096 C  CA  . THR A 1 187 ? 194.389 224.982 320.537 1.00 41.76 ? 187 THR A CA  1 
ATOM   1097 C  C   . THR A 1 187 ? 195.476 224.897 321.599 1.00 41.76 ? 187 THR A C   1 
ATOM   1098 O  O   . THR A 1 187 ? 196.332 225.769 321.715 1.00 41.76 ? 187 THR A O   1 
ATOM   1099 C  CB  . THR A 1 187 ? 194.590 223.896 319.482 1.00 41.76 ? 187 THR A CB  1 
ATOM   1100 O  OG1 . THR A 1 187 ? 195.901 223.999 318.935 1.00 41.76 ? 187 THR A OG1 1 
ATOM   1101 C  CG2 . THR A 1 187 ? 193.596 224.060 318.368 1.00 41.76 ? 187 THR A CG2 1 
ATOM   1102 N  N   . LEU A 1 188 ? 195.420 223.834 322.392 1.00 43.88 ? 188 LEU A N   1 
ATOM   1103 C  CA  . LEU A 1 188 ? 196.296 223.677 323.544 1.00 43.88 ? 188 LEU A CA  1 
ATOM   1104 C  C   . LEU A 1 188 ? 196.286 222.217 323.963 1.00 43.88 ? 188 LEU A C   1 
ATOM   1105 O  O   . LEU A 1 188 ? 195.218 221.630 324.101 1.00 43.88 ? 188 LEU A O   1 
ATOM   1106 C  CB  . LEU A 1 188 ? 195.800 224.574 324.677 1.00 43.88 ? 188 LEU A CB  1 
ATOM   1107 C  CG  . LEU A 1 188 ? 196.446 224.613 326.045 1.00 43.88 ? 188 LEU A CG  1 
ATOM   1108 C  CD1 . LEU A 1 188 ? 196.296 225.984 326.596 1.00 43.88 ? 188 LEU A CD1 1 
ATOM   1109 C  CD2 . LEU A 1 188 ? 195.740 223.642 326.944 1.00 43.88 ? 188 LEU A CD2 1 
ATOM   1110 N  N   . LEU A 1 189 ? 197.456 221.635 324.169 1.00 44.58 ? 189 LEU A N   1 
ATOM   1111 C  CA  . LEU A 1 189 ? 197.554 220.264 324.649 1.00 44.58 ? 189 LEU A CA  1 
ATOM   1112 C  C   . LEU A 1 189 ? 197.677 220.248 326.164 1.00 44.58 ? 189 LEU A C   1 
ATOM   1113 O  O   . LEU A 1 189 ? 198.364 221.083 326.745 1.00 44.58 ? 189 LEU A O   1 
ATOM   1114 C  CB  . LEU A 1 189 ? 198.748 219.562 324.020 1.00 44.58 ? 189 LEU A CB  1 
ATOM   1115 C  CG  . LEU A 1 189 ? 198.515 219.125 322.584 1.00 44.58 ? 189 LEU A CG  1 
ATOM   1116 C  CD1 . LEU A 1 189 ? 199.714 218.379 322.116 1.00 44.58 ? 189 LEU A CD1 1 
ATOM   1117 C  CD2 . LEU A 1 189 ? 197.304 218.262 322.487 1.00 44.58 ? 189 LEU A CD2 1 
ATOM   1118 N  N   . THR A 1 190 ? 197.036 219.288 326.808 1.00 52.43 ? 190 THR A N   1 
ATOM   1119 C  CA  . THR A 1 190 ? 197.000 219.254 328.260 1.00 52.43 ? 190 THR A CA  1 
ATOM   1120 C  C   . THR A 1 190 ? 197.505 217.910 328.753 1.00 52.43 ? 190 THR A C   1 
ATOM   1121 O  O   . THR A 1 190 ? 197.055 216.863 328.279 1.00 52.43 ? 190 THR A O   1 
ATOM   1122 C  CB  . THR A 1 190 ? 195.574 219.490 328.770 1.00 52.43 ? 190 THR A CB  1 
ATOM   1123 O  OG1 . THR A 1 190 ? 195.258 220.883 328.695 1.00 52.43 ? 190 THR A OG1 1 
ATOM   1124 C  CG2 . THR A 1 190 ? 195.428 219.016 330.198 1.00 52.43 ? 190 THR A CG2 1 
ATOM   1125 N  N   . LEU A 1 191 ? 198.426 217.941 329.709 1.00 61.42 ? 191 LEU A N   1 
ATOM   1126 C  CA  . LEU A 1 191 ? 198.946 216.737 330.343 1.00 61.42 ? 191 LEU A CA  1 
ATOM   1127 C  C   . LEU A 1 191 ? 198.640 216.849 331.829 1.00 61.42 ? 191 LEU A C   1 
ATOM   1128 O  O   . LEU A 1 191 ? 199.253 217.649 332.538 1.00 61.42 ? 191 LEU A O   1 
ATOM   1129 C  CB  . LEU A 1 191 ? 200.443 216.584 330.103 1.00 61.42 ? 191 LEU A CB  1 
ATOM   1130 C  CG  . LEU A 1 191 ? 201.097 215.334 330.673 1.00 61.42 ? 191 LEU A CG  1 
ATOM   1131 C  CD1 . LEU A 1 191 ? 200.296 214.103 330.337 1.00 61.42 ? 191 LEU A CD1 1 
ATOM   1132 C  CD2 . LEU A 1 191 ? 202.515 215.224 330.143 1.00 61.42 ? 191 LEU A CD2 1 
ATOM   1133 N  N   . SER A 1 192 ? 197.722 216.023 332.303 1.00 69.74 ? 192 SER A N   1 
ATOM   1134 C  CA  . SER A 1 192 ? 197.285 216.072 333.688 1.00 69.74 ? 192 SER A CA  1 
ATOM   1135 C  C   . SER A 1 192 ? 198.317 215.408 334.590 1.00 69.74 ? 192 SER A C   1 
ATOM   1136 O  O   . SER A 1 192 ? 199.084 214.546 334.162 1.00 69.74 ? 192 SER A O   1 
ATOM   1137 C  CB  . SER A 1 192 ? 195.892 215.452 333.861 1.00 69.74 ? 192 SER A CB  1 
ATOM   1138 O  OG  . SER A 1 192 ? 195.713 214.271 333.119 1.00 69.74 ? 192 SER A OG  1 
ATOM   1139 N  N   . ARG A 1 193 ? 198.330 215.826 335.855 1.00 75.93 ? 193 ARG A N   1 
ATOM   1140 C  CA  . ARG A 1 193 ? 199.276 215.272 336.821 1.00 75.93 ? 193 ARG A CA  1 
ATOM   1141 C  C   . ARG A 1 193 ? 199.008 213.800 337.090 1.00 75.93 ? 193 ARG A C   1 
ATOM   1142 O  O   . ARG A 1 193 ? 199.952 213.011 337.183 1.00 75.93 ? 193 ARG A O   1 
ATOM   1143 C  CB  . ARG A 1 193 ? 199.245 216.075 338.125 1.00 75.93 ? 193 ARG A CB  1 
ATOM   1144 C  CG  . ARG A 1 193 ? 200.013 215.427 339.268 1.00 75.93 ? 193 ARG A CG  1 
ATOM   1145 C  CD  . ARG A 1 193 ? 200.355 216.428 340.350 1.00 75.93 ? 193 ARG A CD  1 
ATOM   1146 N  NE  . ARG A 1 193 ? 199.246 217.330 340.626 1.00 75.93 ? 193 ARG A NE  1 
ATOM   1147 C  CZ  . ARG A 1 193 ? 198.112 216.974 341.209 1.00 75.93 ? 193 ARG A CZ  1 
ATOM   1148 N  NH1 . ARG A 1 193 ? 197.900 215.731 341.605 1.00 75.93 ? 193 ARG A NH1 1 
ATOM   1149 N  NH2 . ARG A 1 193 ? 197.171 217.891 341.409 1.00 75.93 ? 193 ARG A NH2 1 
ATOM   1150 N  N   . ALA A 1 194 ? 197.740 213.409 337.228 1.00 77.16 ? 194 ALA A N   1 
ATOM   1151 C  CA  . ALA A 1 194 ? 197.440 212.009 337.515 1.00 77.16 ? 194 ALA A CA  1 
ATOM   1152 C  C   . ALA A 1 194 ? 197.851 211.081 336.376 1.00 77.16 ? 194 ALA A C   1 
ATOM   1153 O  O   . ALA A 1 194 ? 198.408 210.006 336.624 1.00 77.16 ? 194 ALA A O   1 
ATOM   1154 C  CB  . ALA A 1 194 ? 195.949 211.847 337.822 1.00 77.16 ? 194 ALA A CB  1 
ATOM   1155 N  N   . ASP A 1 195 ? 197.601 211.481 335.128 1.00 75.89 ? 195 ASP A N   1 
ATOM   1156 C  CA  . ASP A 1 195 ? 197.990 210.660 333.983 1.00 75.89 ? 195 ASP A CA  1 
ATOM   1157 C  C   . ASP A 1 195 ? 199.496 210.506 333.908 1.00 75.89 ? 195 ASP A C   1 
ATOM   1158 O  O   . ASP A 1 195 ? 200.008 209.410 333.649 1.00 75.89 ? 195 ASP A O   1 
ATOM   1159 C  CB  . ASP A 1 195 ? 197.422 211.282 332.716 1.00 75.89 ? 195 ASP A CB  1 
ATOM   1160 C  CG  . ASP A 1 195 ? 195.945 211.536 332.854 1.00 75.89 ? 195 ASP A CG  1 
ATOM   1161 O  OD1 . ASP A 1 195 ? 195.533 211.925 333.957 1.00 75.89 ? 195 ASP A OD1 1 
ATOM   1162 O  OD2 . ASP A 1 195 ? 195.187 211.420 331.898 1.00 75.89 ? 195 ASP A OD2 1 
ATOM   1163 N  N   . PHE A 1 196 ? 200.221 211.600 334.114 1.00 74.26 ? 196 PHE A N   1 
ATOM   1164 C  CA  . PHE A 1 196 ? 201.671 211.532 334.114 1.00 74.26 ? 196 PHE A CA  1 
ATOM   1165 C  C   . PHE A 1 196 ? 202.174 210.656 335.256 1.00 74.26 ? 196 PHE A C   1 
ATOM   1166 O  O   . PHE A 1 196 ? 203.135 209.897 335.096 1.00 74.26 ? 196 PHE A O   1 
ATOM   1167 C  CB  . PHE A 1 196 ? 202.261 212.926 334.233 1.00 74.26 ? 196 PHE A CB  1 
ATOM   1168 C  CG  . PHE A 1 196 ? 203.751 212.936 334.228 1.00 74.26 ? 196 PHE A CG  1 
ATOM   1169 C  CD1 . PHE A 1 196 ? 204.446 212.350 333.198 1.00 74.26 ? 196 PHE A CD1 1 
ATOM   1170 C  CD2 . PHE A 1 196 ? 204.458 213.484 335.279 1.00 74.26 ? 196 PHE A CD2 1 
ATOM   1171 C  CE1 . PHE A 1 196 ? 205.806 212.345 333.196 1.00 74.26 ? 196 PHE A CE1 1 
ATOM   1172 C  CE2 . PHE A 1 196 ? 205.822 213.476 335.281 1.00 74.26 ? 196 PHE A CE2 1 
ATOM   1173 C  CZ  . PHE A 1 196 ? 206.496 212.900 334.230 1.00 74.26 ? 196 PHE A CZ  1 
ATOM   1174 N  N   . ALA A 1 197 ? 201.532 210.740 336.419 1.00 77.88 ? 197 ALA A N   1 
ATOM   1175 C  CA  . ALA A 1 197 ? 201.919 209.875 337.526 1.00 77.88 ? 197 ALA A CA  1 
ATOM   1176 C  C   . ALA A 1 197 ? 201.693 208.416 337.167 1.00 77.88 ? 197 ALA A C   1 
ATOM   1177 O  O   . ALA A 1 197 ? 202.517 207.553 337.496 1.00 77.88 ? 197 ALA A O   1 
ATOM   1178 C  CB  . ALA A 1 197 ? 201.142 210.255 338.786 1.00 77.88 ? 197 ALA A CB  1 
ATOM   1179 N  N   . ALA A 1 198 ? 200.594 208.127 336.473 1.00 78.63 ? 198 ALA A N   1 
ATOM   1180 C  CA  . ALA A 1 198 ? 200.338 206.763 336.015 1.00 78.63 ? 198 ALA A CA  1 
ATOM   1181 C  C   . ALA A 1 198 ? 201.412 206.293 335.038 1.00 78.63 ? 198 ALA A C   1 
ATOM   1182 O  O   . ALA A 1 198 ? 201.904 205.162 335.137 1.00 78.63 ? 198 ALA A O   1 
ATOM   1183 C  CB  . ALA A 1 198 ? 198.953 206.679 335.371 1.00 78.63 ? 198 ALA A CB  1 
ATOM   1184 N  N   . VAL A 1 199 ? 201.798 207.153 334.099 1.00 78.84 ? 199 VAL A N   1 
ATOM   1185 C  CA  . VAL A 1 199 ? 202.842 206.788 333.146 1.00 78.84 ? 199 VAL A CA  1 
ATOM   1186 C  C   . VAL A 1 199 ? 204.157 206.546 333.870 1.00 78.84 ? 199 VAL A C   1 
ATOM   1187 O  O   . VAL A 1 199 ? 204.931 205.656 333.500 1.00 78.84 ? 199 VAL A O   1 
ATOM   1188 C  CB  . VAL A 1 199 ? 202.985 207.863 332.055 1.00 78.84 ? 199 VAL A CB  1 
ATOM   1189 C  CG1 . VAL A 1 199 ? 204.003 207.420 331.030 1.00 78.84 ? 199 VAL A CG1 1 
ATOM   1190 C  CG2 . VAL A 1 199 ? 201.656 208.113 331.378 1.00 78.84 ? 199 VAL A CG2 1 
ATOM   1191 N  N   . VAL A 1 200 ? 204.442 207.347 334.896 1.00 81.15 ? 200 VAL A N   1 
ATOM   1192 C  CA  . VAL A 1 200 ? 205.646 207.135 335.696 1.00 81.15 ? 200 VAL A CA  1 
ATOM   1193 C  C   . VAL A 1 200 ? 205.590 205.782 336.391 1.00 81.15 ? 200 VAL A C   1 
ATOM   1194 O  O   . VAL A 1 200 ? 206.563 205.018 336.388 1.00 81.15 ? 200 VAL A O   1 
ATOM   1195 C  CB  . VAL A 1 200 ? 205.826 208.274 336.714 1.00 81.15 ? 200 VAL A CB  1 
ATOM   1196 C  CG1 . VAL A 1 200 ? 206.833 207.869 337.772 1.00 81.15 ? 200 VAL A CG1 1 
ATOM   1197 C  CG2 . VAL A 1 200 ? 206.283 209.535 336.020 1.00 81.15 ? 200 VAL A CG2 1 
ATOM   1198 N  N   . ALA A 1 201 ? 204.439 205.458 336.979 1.00 82.01 ? 201 ALA A N   1 
ATOM   1199 C  CA  . ALA A 1 201 ? 204.271 204.184 337.667 1.00 82.01 ? 201 ALA A CA  1 
ATOM   1200 C  C   . ALA A 1 201 ? 204.268 202.997 336.715 1.00 82.01 ? 201 ALA A C   1 
ATOM   1201 O  O   . ALA A 1 201 ? 204.417 201.858 337.165 1.00 82.01 ? 201 ALA A O   1 
ATOM   1202 C  CB  . ALA A 1 201 ? 202.979 204.192 338.481 1.00 82.01 ? 201 ALA A CB  1 
ATOM   1203 N  N   . ASN A 1 202 ? 204.096 203.232 335.418 1.00 82.10 ? 202 ASN A N   1 
ATOM   1204 C  CA  . ASN A 1 202 ? 204.145 202.139 334.457 1.00 82.10 ? 202 ASN A CA  1 
ATOM   1205 C  C   . ASN A 1 202 ? 205.575 201.798 334.050 1.00 82.10 ? 202 ASN A C   1 
ATOM   1206 O  O   . ASN A 1 202 ? 205.923 200.618 333.944 1.00 82.10 ? 202 ASN A O   1 
ATOM   1207 C  CB  . ASN A 1 202 ? 203.307 202.498 333.230 1.00 82.10 ? 202 ASN A CB  1 
ATOM   1208 C  CG  . ASN A 1 202 ? 203.079 201.319 332.305 1.00 82.10 ? 202 ASN A CG  1 
ATOM   1209 O  OD1 . ASN A 1 202 ? 204.001 200.575 331.978 1.00 82.10 ? 202 ASN A OD1 1 
ATOM   1210 N  ND2 . ASN A 1 202 ? 201.838 201.148 331.873 1.00 82.10 ? 202 ASN A ND2 1 
ATOM   1211 N  N   . SER A 1 203 ? 206.417 202.803 333.813 1.00 84.50 ? 203 SER A N   1 
ATOM   1212 C  CA  . SER A 1 203 ? 207.755 202.572 333.278 1.00 84.50 ? 203 SER A CA  1 
ATOM   1213 C  C   . SER A 1 203 ? 208.816 202.794 334.344 1.00 84.50 ? 203 SER A C   1 
ATOM   1214 O  O   . SER A 1 203 ? 208.952 203.917 334.850 1.00 84.50 ? 203 SER A O   1 
ATOM   1215 C  CB  . SER A 1 203 ? 208.019 203.475 332.078 1.00 84.50 ? 203 SER A CB  1 
ATOM   1216 O  OG  . SER A 1 203 ? 209.409 203.636 331.869 1.00 84.50 ? 203 SER A OG  1 
ATOM   1217 N  N   . PRO A 1 204 ? 209.577 201.762 334.717 1.00 84.79 ? 204 PRO A N   1 
ATOM   1218 C  CA  . PRO A 1 204 ? 210.646 201.953 335.711 1.00 84.79 ? 204 PRO A CA  1 
ATOM   1219 C  C   . PRO A 1 204 ? 211.739 202.905 335.268 1.00 84.79 ? 204 PRO A C   1 
ATOM   1220 O  O   . PRO A 1 204 ? 212.329 203.588 336.115 1.00 84.79 ? 204 PRO A O   1 
ATOM   1221 C  CB  . PRO A 1 204 ? 211.195 200.535 335.909 1.00 84.79 ? 204 PRO A CB  1 
ATOM   1222 C  CG  . PRO A 1 204 ? 210.829 199.812 334.658 1.00 84.79 ? 204 PRO A CG  1 
ATOM   1223 C  CD  . PRO A 1 204 ? 209.509 200.374 334.236 1.00 84.79 ? 204 PRO A CD  1 
ATOM   1224 N  N   . ALA A 1 205 ? 212.043 202.957 333.969 1.00 85.01 ? 205 ALA A N   1 
ATOM   1225 C  CA  . ALA A 1 205 ? 213.091 203.853 333.493 1.00 85.01 ? 205 ALA A CA  1 
ATOM   1226 C  C   . ALA A 1 205 ? 212.732 205.302 333.771 1.00 85.01 ? 205 ALA A C   1 
ATOM   1227 O  O   . ALA A 1 205 ? 213.586 206.098 334.181 1.00 85.01 ? 205 ALA A O   1 
ATOM   1228 C  CB  . ALA A 1 205 ? 213.325 203.642 331.999 1.00 85.01 ? 205 ALA A CB  1 
ATOM   1229 N  N   . LEU A 1 206 ? 211.468 205.659 333.557 1.00 86.07 ? 206 LEU A N   1 
ATOM   1230 C  CA  . LEU A 1 206 ? 211.021 207.006 333.875 1.00 86.07 ? 206 LEU A CA  1 
ATOM   1231 C  C   . LEU A 1 206 ? 211.130 207.273 335.369 1.00 86.07 ? 206 LEU A C   1 
ATOM   1232 O  O   . LEU A 1 206 ? 211.511 208.374 335.781 1.00 86.07 ? 206 LEU A O   1 
ATOM   1233 C  CB  . LEU A 1 206 ? 209.589 207.212 333.387 1.00 86.07 ? 206 LEU A CB  1 
ATOM   1234 C  CG  . LEU A 1 206 ? 208.946 208.574 333.637 1.00 86.07 ? 206 LEU A CG  1 
ATOM   1235 C  CD1 . LEU A 1 206 ? 209.896 209.701 333.280 1.00 86.07 ? 206 LEU A CD1 1 
ATOM   1236 C  CD2 . LEU A 1 206 ? 207.661 208.684 332.845 1.00 86.07 ? 206 LEU A CD2 1 
ATOM   1237 N  N   . ARG A 1 207 ? 210.809 206.276 336.197 1.00 86.18 ? 207 ARG A N   1 
ATOM   1238 C  CA  . ARG A 1 207 ? 210.958 206.439 337.640 1.00 86.18 ? 207 ARG A CA  1 
ATOM   1239 C  C   . ARG A 1 207 ? 212.403 206.742 338.007 1.00 86.18 ? 207 ARG A C   1 
ATOM   1240 O  O   . ARG A 1 207 ? 212.681 207.662 338.787 1.00 86.18 ? 207 ARG A O   1 
ATOM   1241 C  CB  . ARG A 1 207 ? 210.493 205.180 338.373 1.00 86.18 ? 207 ARG A CB  1 
ATOM   1242 C  CG  . ARG A 1 207 ? 209.846 205.477 339.716 1.00 86.18 ? 207 ARG A CG  1 
ATOM   1243 C  CD  . ARG A 1 207 ? 209.205 204.251 340.350 1.00 86.18 ? 207 ARG A CD  1 
ATOM   1244 N  NE  . ARG A 1 207 ? 208.021 203.784 339.643 1.00 86.18 ? 207 ARG A NE  1 
ATOM   1245 C  CZ  . ARG A 1 207 ? 208.019 202.755 338.808 1.00 86.18 ? 207 ARG A CZ  1 
ATOM   1246 N  NH1 . ARG A 1 207 ? 209.123 202.078 338.545 1.00 86.18 ? 207 ARG A NH1 1 
ATOM   1247 N  NH2 . ARG A 1 207 ? 206.883 202.399 338.219 1.00 86.18 ? 207 ARG A NH2 1 
ATOM   1248 N  N   . SER A 1 208 ? 213.338 205.968 337.458 1.00 87.16 ? 208 SER A N   1 
ATOM   1249 C  CA  . SER A 1 208 ? 214.744 206.168 337.784 1.00 87.16 ? 208 SER A CA  1 
ATOM   1250 C  C   . SER A 1 208 ? 215.235 207.522 337.298 1.00 87.16 ? 208 SER A C   1 
ATOM   1251 O  O   . SER A 1 208 ? 215.974 208.213 338.009 1.00 87.16 ? 208 SER A O   1 
ATOM   1252 C  CB  . SER A 1 208 ? 215.581 205.043 337.180 1.00 87.16 ? 208 SER A CB  1 
ATOM   1253 O  OG  . SER A 1 208 ? 215.127 204.719 335.878 1.00 87.16 ? 208 SER A OG  1 
ATOM   1254 N  N   . HIS A 1 209 ? 214.832 207.923 336.090 1.00 86.67 ? 209 HIS A N   1 
ATOM   1255 C  CA  . HIS A 1 209 ? 215.251 209.223 335.576 1.00 86.67 ? 209 HIS A CA  1 
ATOM   1256 C  C   . HIS A 1 209 ? 214.685 210.356 336.418 1.00 86.67 ? 209 HIS A C   1 
ATOM   1257 O  O   . HIS A 1 209 ? 215.377 211.343 336.684 1.00 86.67 ? 209 HIS A O   1 
ATOM   1258 C  CB  . HIS A 1 209 ? 214.834 209.376 334.115 1.00 86.67 ? 209 HIS A CB  1 
ATOM   1259 C  CG  . HIS A 1 209 ? 215.501 210.520 333.414 1.00 86.67 ? 209 HIS A CG  1 
ATOM   1260 N  ND1 . HIS A 1 209 ? 215.496 211.805 333.913 1.00 86.67 ? 209 HIS A ND1 1 
ATOM   1261 C  CD2 . HIS A 1 209 ? 216.201 210.572 332.256 1.00 86.67 ? 209 HIS A CD2 1 
ATOM   1262 C  CE1 . HIS A 1 209 ? 216.153 212.601 333.089 1.00 86.67 ? 209 HIS A CE1 1 
ATOM   1263 N  NE2 . HIS A 1 209 ? 216.591 211.877 332.075 1.00 86.67 ? 209 HIS A NE2 1 
ATOM   1264 N  N   . LEU A 1 210 ? 213.428 210.237 336.844 1.00 87.53 ? 210 LEU A N   1 
ATOM   1265 C  CA  . LEU A 1 210 ? 212.835 211.262 337.694 1.00 87.53 ? 210 LEU A CA  1 
ATOM   1266 C  C   . LEU A 1 210 ? 213.544 211.340 339.038 1.00 87.53 ? 210 LEU A C   1 
ATOM   1267 O  O   . LEU A 1 210 ? 213.795 212.435 339.555 1.00 87.53 ? 210 LEU A O   1 
ATOM   1268 C  CB  . LEU A 1 210 ? 211.347 210.980 337.886 1.00 87.53 ? 210 LEU A CB  1 
ATOM   1269 C  CG  . LEU A 1 210 ? 210.426 212.171 337.635 1.00 87.53 ? 210 LEU A CG  1 
ATOM   1270 C  CD1 . LEU A 1 210 ? 210.780 212.825 336.316 1.00 87.53 ? 210 LEU A CD1 1 
ATOM   1271 C  CD2 . LEU A 1 210 ? 208.986 211.724 337.634 1.00 87.53 ? 210 LEU A CD2 1 
ATOM   1272 N  N   . ALA A 1 211 ? 213.873 210.185 339.622 1.00 89.28 ? 211 ALA A N   1 
ATOM   1273 C  CA  . ALA A 1 211 ? 214.590 210.182 340.893 1.00 89.28 ? 211 ALA A CA  1 
ATOM   1274 C  C   . ALA A 1 211 ? 215.965 210.818 340.745 1.00 89.28 ? 211 ALA A C   1 
ATOM   1275 O  O   . ALA A 1 211 ? 216.401 211.584 341.612 1.00 89.28 ? 211 ALA A O   1 
ATOM   1276 C  CB  . ALA A 1 211 ? 214.712 208.756 341.427 1.00 89.28 ? 211 ALA A CB  1 
ATOM   1277 N  N   . ALA A 1 212 ? 216.660 210.519 339.646 1.00 89.14 ? 212 ALA A N   1 
ATOM   1278 C  CA  . ALA A 1 212 ? 217.962 211.132 339.408 1.00 89.14 ? 212 ALA A CA  1 
ATOM   1279 C  C   . ALA A 1 212 ? 217.840 212.636 339.206 1.00 89.14 ? 212 ALA A C   1 
ATOM   1280 O  O   . ALA A 1 212 ? 218.655 213.406 339.726 1.00 89.14 ? 212 ALA A O   1 
ATOM   1281 C  CB  . ALA A 1 212 ? 218.633 210.484 338.198 1.00 89.14 ? 212 ALA A CB  1 
ATOM   1282 N  N   . PHE A 1 213 ? 216.827 213.073 338.460 1.00 87.82 ? 213 PHE A N   1 
ATOM   1283 C  CA  . PHE A 1 213 ? 216.667 214.495 338.191 1.00 87.82 ? 213 PHE A CA  1 
ATOM   1284 C  C   . PHE A 1 213 ? 216.299 215.267 339.447 1.00 87.82 ? 213 PHE A C   1 
ATOM   1285 O  O   . PHE A 1 213 ? 216.730 216.413 339.616 1.00 87.82 ? 213 PHE A O   1 
ATOM   1286 C  CB  . PHE A 1 213 ? 215.610 214.704 337.110 1.00 87.82 ? 213 PHE A CB  1 
ATOM   1287 C  CG  . PHE A 1 213 ? 214.964 216.056 337.148 1.00 87.82 ? 213 PHE A CG  1 
ATOM   1288 C  CD1 . PHE A 1 213 ? 215.643 217.171 336.698 1.00 87.82 ? 213 PHE A CD1 1 
ATOM   1289 C  CD2 . PHE A 1 213 ? 213.677 216.211 337.629 1.00 87.82 ? 213 PHE A CD2 1 
ATOM   1290 C  CE1 . PHE A 1 213 ? 215.054 218.413 336.729 1.00 87.82 ? 213 PHE A CE1 1 
ATOM   1291 C  CE2 . PHE A 1 213 ? 213.085 217.451 337.664 1.00 87.82 ? 213 PHE A CE2 1 
ATOM   1292 C  CZ  . PHE A 1 213 ? 213.774 218.554 337.215 1.00 87.82 ? 213 PHE A CZ  1 
ATOM   1293 N  N   . THR A 1 214 ? 215.516 214.656 340.337 1.00 90.33 ? 214 THR A N   1 
ATOM   1294 C  CA  . THR A 1 214 ? 215.080 215.353 341.541 1.00 90.33 ? 214 THR A CA  1 
ATOM   1295 C  C   . THR A 1 214 ? 216.258 215.786 342.400 1.00 90.33 ? 214 THR A C   1 
ATOM   1296 O  O   . THR A 1 214 ? 216.192 216.829 343.061 1.00 90.33 ? 214 THR A O   1 
ATOM   1297 C  CB  . THR A 1 214 ? 214.136 214.466 342.348 1.00 90.33 ? 214 THR A CB  1 
ATOM   1298 O  OG1 . THR A 1 214 ? 213.209 213.825 341.462 1.00 90.33 ? 214 THR A OG1 1 
ATOM   1299 C  CG2 . THR A 1 214 ? 213.365 215.303 343.357 1.00 90.33 ? 214 THR A CG2 1 
ATOM   1300 N  N   . ALA A 1 215 ? 217.334 215.010 342.409 1.00 89.52 ? 215 ALA A N   1 
ATOM   1301 C  CA  . ALA A 1 215 ? 218.515 215.368 343.181 1.00 89.52 ? 215 ALA A CA  1 
ATOM   1302 C  C   . ALA A 1 215 ? 219.235 216.562 342.566 1.00 89.52 ? 215 ALA A C   1 
ATOM   1303 O  O   . ALA A 1 215 ? 219.263 216.722 341.346 1.00 89.52 ? 215 ALA A O   1 
ATOM   1304 C  CB  . ALA A 1 215 ? 219.454 214.182 343.285 1.00 89.52 ? 215 ALA A CB  1 
ATOM   1305 N  N   . ALA A 1 246 ? 219.001 219.608 314.447 1.00 62.00 ? 246 ALA A N   1 
ATOM   1306 C  CA  . ALA A 1 246 ? 217.842 219.380 313.596 1.00 62.00 ? 246 ALA A CA  1 
ATOM   1307 C  C   . ALA A 1 246 ? 217.570 217.892 313.451 1.00 62.00 ? 246 ALA A C   1 
ATOM   1308 O  O   . ALA A 1 246 ? 218.445 217.124 313.051 1.00 62.00 ? 246 ALA A O   1 
ATOM   1309 C  CB  . ALA A 1 246 ? 218.043 220.019 312.235 1.00 62.00 ? 246 ALA A CB  1 
ATOM   1310 N  N   . ASP A 1 247 ? 216.347 217.493 313.781 1.00 63.29 ? 247 ASP A N   1 
ATOM   1311 C  CA  . ASP A 1 247 ? 215.918 216.106 313.720 1.00 63.29 ? 247 ASP A CA  1 
ATOM   1312 C  C   . ASP A 1 247 ? 214.986 215.903 312.536 1.00 63.29 ? 247 ASP A C   1 
ATOM   1313 O  O   . ASP A 1 247 ? 214.148 216.755 312.239 1.00 63.29 ? 247 ASP A O   1 
ATOM   1314 C  CB  . ASP A 1 247 ? 215.221 215.685 315.011 1.00 63.29 ? 247 ASP A CB  1 
ATOM   1315 C  CG  . ASP A 1 247 ? 216.156 215.674 316.194 1.00 63.29 ? 247 ASP A CG  1 
ATOM   1316 O  OD1 . ASP A 1 247 ? 217.136 216.443 316.177 1.00 63.29 ? 247 ASP A OD1 1 
ATOM   1317 O  OD2 . ASP A 1 247 ? 215.916 214.899 317.141 1.00 63.29 ? 247 ASP A OD2 1 
ATOM   1318 N  N   . TYR A 1 248 ? 215.141 214.771 311.869 1.00 64.32 ? 248 TYR A N   1 
ATOM   1319 C  CA  . TYR A 1 248 ? 214.312 214.392 310.737 1.00 64.32 ? 248 TYR A CA  1 
ATOM   1320 C  C   . TYR A 1 248 ? 213.287 213.378 311.212 1.00 64.32 ? 248 TYR A C   1 
ATOM   1321 O  O   . TYR A 1 248 ? 213.651 212.312 311.719 1.00 64.32 ? 248 TYR A O   1 
ATOM   1322 C  CB  . TYR A 1 248 ? 215.181 213.787 309.633 1.00 64.32 ? 248 TYR A CB  1 
ATOM   1323 C  CG  . TYR A 1 248 ? 214.436 213.122 308.490 1.00 64.32 ? 248 TYR A CG  1 
ATOM   1324 C  CD1 . TYR A 1 248 ? 214.029 211.793 308.577 1.00 64.32 ? 248 TYR A CD1 1 
ATOM   1325 C  CD2 . TYR A 1 248 ? 214.193 213.795 307.308 1.00 64.32 ? 248 TYR A CD2 1 
ATOM   1326 C  CE1 . TYR A 1 248 ? 213.364 211.176 307.535 1.00 64.32 ? 248 TYR A CE1 1 
ATOM   1327 C  CE2 . TYR A 1 248 ? 213.536 213.179 306.258 1.00 64.32 ? 248 TYR A CE2 1 
ATOM   1328 C  CZ  . TYR A 1 248 ? 213.120 211.879 306.377 1.00 64.32 ? 248 TYR A CZ  1 
ATOM   1329 O  OH  . TYR A 1 248 ? 212.459 211.289 305.325 1.00 64.32 ? 248 TYR A OH  1 
ATOM   1330 N  N   . GLU A 1 249 ? 212.012 213.707 311.061 1.00 59.15 ? 249 GLU A N   1 
ATOM   1331 C  CA  . GLU A 1 249 ? 210.938 212.810 311.462 1.00 59.15 ? 249 GLU A CA  1 
ATOM   1332 C  C   . GLU A 1 249 ? 209.981 212.711 310.286 1.00 59.15 ? 249 GLU A C   1 
ATOM   1333 O  O   . GLU A 1 249 ? 209.299 213.686 309.960 1.00 59.15 ? 249 GLU A O   1 
ATOM   1334 C  CB  . GLU A 1 249 ? 210.223 213.308 312.712 1.00 59.15 ? 249 GLU A CB  1 
ATOM   1335 C  CG  . GLU A 1 249 ? 209.241 212.304 313.256 1.00 59.15 ? 249 GLU A CG  1 
ATOM   1336 C  CD  . GLU A 1 249 ? 208.269 212.912 314.226 1.00 59.15 ? 249 GLU A CD  1 
ATOM   1337 O  OE1 . GLU A 1 249 ? 207.841 214.056 313.990 1.00 59.15 ? 249 GLU A OE1 1 
ATOM   1338 O  OE2 . GLU A 1 249 ? 207.936 212.249 315.229 1.00 59.15 ? 249 GLU A OE2 1 
ATOM   1339 N  N   . LEU A 1 250 ? 209.942 211.556 309.637 1.00 56.76 ? 250 LEU A N   1 
ATOM   1340 C  CA  . LEU A 1 250 ? 209.049 211.339 308.510 1.00 56.76 ? 250 LEU A CA  1 
ATOM   1341 C  C   . LEU A 1 250 ? 207.777 210.654 308.990 1.00 56.76 ? 250 LEU A C   1 
ATOM   1342 O  O   . LEU A 1 250 ? 207.843 209.627 309.672 1.00 56.76 ? 250 LEU A O   1 
ATOM   1343 C  CB  . LEU A 1 250 ? 209.734 210.497 307.435 1.00 56.76 ? 250 LEU A CB  1 
ATOM   1344 C  CG  . LEU A 1 250 ? 208.907 210.010 306.245 1.00 56.76 ? 250 LEU A CG  1 
ATOM   1345 C  CD1 . LEU A 1 250 ? 208.046 211.112 305.677 1.00 56.76 ? 250 LEU A CD1 1 
ATOM   1346 C  CD2 . LEU A 1 250 ? 209.802 209.427 305.171 1.00 56.76 ? 250 LEU A CD2 1 
ATOM   1347 N  N   . LYS A 1 251 ? 206.628 211.233 308.654 1.00 49.12 ? 251 LYS A N   1 
ATOM   1348 C  CA  . LYS A 1 251 ? 205.343 210.628 308.983 1.00 49.12 ? 251 LYS A CA  1 
ATOM   1349 C  C   . LYS A 1 251 ? 204.311 210.973 307.915 1.00 49.12 ? 251 LYS A C   1 
ATOM   1350 O  O   . LYS A 1 251 ? 203.824 212.108 307.871 1.00 49.12 ? 251 LYS A O   1 
ATOM   1351 C  CB  . LYS A 1 251 ? 204.863 211.079 310.357 1.00 49.12 ? 251 LYS A CB  1 
ATOM   1352 C  CG  . LYS A 1 251 ? 205.342 212.433 310.768 1.00 49.12 ? 251 LYS A CG  1 
ATOM   1353 C  CD  . LYS A 1 251 ? 204.813 212.757 312.145 1.00 49.12 ? 251 LYS A CD  1 
ATOM   1354 C  CE  . LYS A 1 251 ? 205.240 211.715 313.162 1.00 49.12 ? 251 LYS A CE  1 
ATOM   1355 N  NZ  . LYS A 1 251 ? 204.845 212.081 314.556 1.00 49.12 ? 251 LYS A NZ  1 
ATOM   1356 N  N   . PRO A 1 252 ? 203.916 210.020 307.076 1.00 42.75 ? 252 PRO A N   1 
ATOM   1357 C  CA  . PRO A 1 252 ? 202.996 210.335 305.979 1.00 42.75 ? 252 PRO A CA  1 
ATOM   1358 C  C   . PRO A 1 252 ? 201.620 210.744 306.468 1.00 42.75 ? 252 PRO A C   1 
ATOM   1359 O  O   . PRO A 1 252 ? 201.165 210.344 307.539 1.00 42.75 ? 252 PRO A O   1 
ATOM   1360 C  CB  . PRO A 1 252 ? 202.925 209.026 305.188 1.00 42.75 ? 252 PRO A CB  1 
ATOM   1361 C  CG  . PRO A 1 252 ? 204.111 208.268 305.602 1.00 42.75 ? 252 PRO A CG  1 
ATOM   1362 C  CD  . PRO A 1 252 ? 204.365 208.627 307.025 1.00 42.75 ? 252 PRO A CD  1 
ATOM   1363 N  N   . ARG A 1 253 ? 200.967 211.571 305.662 1.00 37.28 ? 253 ARG A N   1 
ATOM   1364 C  CA  . ARG A 1 253 ? 199.614 212.044 305.903 1.00 37.28 ? 253 ARG A CA  1 
ATOM   1365 C  C   . ARG A 1 253 ? 198.705 211.477 304.830 1.00 37.28 ? 253 ARG A C   1 
ATOM   1366 O  O   . ARG A 1 253 ? 199.001 211.592 303.640 1.00 37.28 ? 253 ARG A O   1 
ATOM   1367 C  CB  . ARG A 1 253 ? 199.569 213.567 305.887 1.00 37.28 ? 253 ARG A CB  1 
ATOM   1368 C  CG  . ARG A 1 253 ? 198.199 214.143 305.761 1.00 37.28 ? 253 ARG A CG  1 
ATOM   1369 C  CD  . ARG A 1 253 ? 197.525 214.253 307.092 1.00 37.28 ? 253 ARG A CD  1 
ATOM   1370 N  NE  . ARG A 1 253 ? 196.159 214.736 306.957 1.00 37.28 ? 253 ARG A NE  1 
ATOM   1371 C  CZ  . ARG A 1 253 ? 195.831 216.007 306.798 1.00 37.28 ? 253 ARG A CZ  1 
ATOM   1372 N  NH1 . ARG A 1 253 ? 196.749 216.954 306.756 1.00 37.28 ? 253 ARG A NH1 1 
ATOM   1373 N  NH2 . ARG A 1 253 ? 194.550 216.335 306.672 1.00 37.28 ? 253 ARG A NH2 1 
ATOM   1374 N  N   . GLU A 1 254 ? 197.606 210.865 305.248 1.00 41.22 ? 254 GLU A N   1 
ATOM   1375 C  CA  . GLU A 1 254 ? 196.677 210.216 304.337 1.00 41.22 ? 254 GLU A CA  1 
ATOM   1376 C  C   . GLU A 1 254 ? 195.416 211.053 304.201 1.00 41.22 ? 254 GLU A C   1 
ATOM   1377 O  O   . GLU A 1 254 ? 194.798 211.420 305.204 1.00 41.22 ? 254 GLU A O   1 
ATOM   1378 C  CB  . GLU A 1 254 ? 196.315 208.818 304.836 1.00 41.22 ? 254 GLU A CB  1 
ATOM   1379 C  CG  . GLU A 1 254 ? 195.731 207.917 303.769 1.00 41.22 ? 254 GLU A CG  1 
ATOM   1380 C  CD  . GLU A 1 254 ? 196.786 207.155 303.000 1.00 41.22 ? 254 GLU A CD  1 
ATOM   1381 O  OE1 . GLU A 1 254 ? 197.987 207.437 303.185 1.00 41.22 ? 254 GLU A OE1 1 
ATOM   1382 O  OE2 . GLU A 1 254 ? 196.413 206.272 302.203 1.00 41.22 ? 254 GLU A OE2 1 
ATOM   1383 N  N   . TYR A 1 255 ? 195.031 211.340 302.965 1.00 36.22 ? 255 TYR A N   1 
ATOM   1384 C  CA  . TYR A 1 255 ? 193.812 212.069 302.664 1.00 36.22 ? 255 TYR A CA  1 
ATOM   1385 C  C   . TYR A 1 255 ? 192.802 211.110 302.059 1.00 36.22 ? 255 TYR A C   1 
ATOM   1386 O  O   . TYR A 1 255 ? 193.112 210.422 301.086 1.00 36.22 ? 255 TYR A O   1 
ATOM   1387 C  CB  . TYR A 1 255 ? 194.087 213.202 301.678 1.00 36.22 ? 255 TYR A CB  1 
ATOM   1388 C  CG  . TYR A 1 255 ? 194.955 214.309 302.207 1.00 36.22 ? 255 TYR A CG  1 
ATOM   1389 C  CD1 . TYR A 1 255 ? 194.430 215.327 302.975 1.00 36.22 ? 255 TYR A CD1 1 
ATOM   1390 C  CD2 . TYR A 1 255 ? 196.306 214.324 301.942 1.00 36.22 ? 255 TYR A CD2 1 
ATOM   1391 C  CE1 . TYR A 1 255 ? 195.226 216.323 303.454 1.00 36.22 ? 255 TYR A CE1 1 
ATOM   1392 C  CE2 . TYR A 1 255 ? 197.104 215.313 302.417 1.00 36.22 ? 255 TYR A CE2 1 
ATOM   1393 C  CZ  . TYR A 1 255 ? 196.564 216.310 303.173 1.00 36.22 ? 255 TYR A CZ  1 
ATOM   1394 O  OH  . TYR A 1 255 ? 197.378 217.304 303.649 1.00 36.22 ? 255 TYR A OH  1 
ATOM   1395 N  N   . GLU A 1 256 ? 191.600 211.075 302.615 1.00 38.10 ? 256 GLU A N   1 
ATOM   1396 C  CA  . GLU A 1 256 ? 190.514 210.245 302.111 1.00 38.10 ? 256 GLU A CA  1 
ATOM   1397 C  C   . GLU A 1 256 ? 189.448 211.134 301.490 1.00 38.10 ? 256 GLU A C   1 
ATOM   1398 O  O   . GLU A 1 256 ? 189.044 212.132 302.091 1.00 38.10 ? 256 GLU A O   1 
ATOM   1399 C  CB  . GLU A 1 256 ? 189.918 209.379 303.219 1.00 38.10 ? 256 GLU A CB  1 
ATOM   1400 C  CG  . GLU A 1 256 ? 190.816 208.244 303.625 1.00 38.10 ? 256 GLU A CG  1 
ATOM   1401 C  CD  . GLU A 1 256 ? 190.338 206.925 303.065 1.00 38.10 ? 256 GLU A CD  1 
ATOM   1402 O  OE1 . GLU A 1 256 ? 189.198 206.864 302.563 1.00 38.10 ? 256 GLU A OE1 1 
ATOM   1403 O  OE2 . GLU A 1 256 ? 191.118 205.953 303.073 1.00 38.10 ? 256 GLU A OE2 1 
ATOM   1404 N  N   . LEU A 1 257 ? 188.993 210.771 300.296 1.00 32.52 ? 257 LEU A N   1 
ATOM   1405 C  CA  . LEU A 1 257 ? 188.020 211.588 299.586 1.00 32.52 ? 257 LEU A CA  1 
ATOM   1406 C  C   . LEU A 1 257 ? 186.714 211.655 300.359 1.00 32.52 ? 257 LEU A C   1 
ATOM   1407 O  O   . LEU A 1 257 ? 186.150 210.630 300.741 1.00 32.52 ? 257 LEU A O   1 
ATOM   1408 C  CB  . LEU A 1 257 ? 187.768 211.019 298.198 1.00 32.52 ? 257 LEU A CB  1 
ATOM   1409 C  CG  . LEU A 1 257 ? 188.361 211.778 297.024 1.00 32.52 ? 257 LEU A CG  1 
ATOM   1410 C  CD1 . LEU A 1 257 ? 189.818 212.033 297.272 1.00 32.52 ? 257 LEU A CD1 1 
ATOM   1411 C  CD2 . LEU A 1 257 ? 188.159 210.989 295.769 1.00 32.52 ? 257 LEU A CD2 1 
ATOM   1412 N  N   . SER A 1 258 ? 186.251 212.870 300.606 1.00 31.58 ? 258 SER A N   1 
ATOM   1413 C  CA  . SER A 1 258 ? 184.953 213.138 301.196 1.00 31.58 ? 258 SER A CA  1 
ATOM   1414 C  C   . SER A 1 258 ? 183.893 213.164 300.102 1.00 31.58 ? 258 SER A C   1 
ATOM   1415 O  O   . SER A 1 258 ? 184.203 213.262 298.919 1.00 31.58 ? 258 SER A O   1 
ATOM   1416 C  CB  . SER A 1 258 ? 184.989 214.460 301.959 1.00 31.58 ? 258 SER A CB  1 
ATOM   1417 O  OG  . SER A 1 258 ? 183.800 214.672 302.693 1.00 31.58 ? 258 SER A OG  1 
ATOM   1418 N  N   . VAL A 1 259 ? 182.631 213.045 300.498 1.00 30.91 ? 259 VAL A N   1 
ATOM   1419 C  CA  . VAL A 1 259 ? 181.527 212.952 299.548 1.00 30.91 ? 259 VAL A CA  1 
ATOM   1420 C  C   . VAL A 1 259 ? 180.508 214.045 299.831 1.00 30.91 ? 259 VAL A C   1 
ATOM   1421 O  O   . VAL A 1 259 ? 180.178 214.313 300.991 1.00 30.91 ? 259 VAL A O   1 
ATOM   1422 C  CB  . VAL A 1 259 ? 180.846 211.570 299.577 1.00 30.91 ? 259 VAL A CB  1 
ATOM   1423 C  CG1 . VAL A 1 259 ? 180.200 211.308 300.915 1.00 30.91 ? 259 VAL A CG1 1 
ATOM   1424 C  CG2 . VAL A 1 259 ? 179.816 211.471 298.483 1.00 30.91 ? 259 VAL A CG2 1 
ATOM   1425 N  N   . ALA A 1 260 ? 180.058 214.710 298.772 1.00 32.23 ? 260 ALA A N   1 
ATOM   1426 C  CA  . ALA A 1 260 ? 178.880 215.566 298.806 1.00 32.23 ? 260 ALA A CA  1 
ATOM   1427 C  C   . ALA A 1 260 ? 177.771 214.792 298.106 1.00 32.23 ? 260 ALA A C   1 
ATOM   1428 O  O   . ALA A 1 260 ? 177.846 214.540 296.900 1.00 32.23 ? 260 ALA A O   1 
ATOM   1429 C  CB  . ALA A 1 260 ? 179.149 216.909 298.137 1.00 32.23 ? 260 ALA A CB  1 
ATOM   1430 N  N   . GLN A 1 261 ? 176.758 214.403 298.870 1.00 33.46 ? 261 GLN A N   1 
ATOM   1431 C  CA  . GLN A 1 261 ? 175.695 213.530 298.404 1.00 33.46 ? 261 GLN A CA  1 
ATOM   1432 C  C   . GLN A 1 261 ? 174.341 214.155 298.657 1.00 33.46 ? 261 GLN A C   1 
ATOM   1433 O  O   . GLN A 1 261 ? 174.151 214.894 299.623 1.00 33.46 ? 261 GLN A O   1 
ATOM   1434 C  CB  . GLN A 1 261 ? 175.728 212.182 299.106 1.00 33.46 ? 261 GLN A CB  1 
ATOM   1435 C  CG  . GLN A 1 261 ? 176.284 211.077 298.271 1.00 33.46 ? 261 GLN A CG  1 
ATOM   1436 C  CD  . GLN A 1 261 ? 176.038 209.743 298.881 1.00 33.46 ? 261 GLN A CD  1 
ATOM   1437 O  OE1 . GLN A 1 261 ? 175.562 209.650 300.006 1.00 33.46 ? 261 GLN A OE1 1 
ATOM   1438 N  NE2 . GLN A 1 261 ? 176.407 208.690 298.170 1.00 33.46 ? 261 GLN A NE2 1 
ATOM   1439 N  N   . THR A 1 262 ? 173.391 213.816 297.800 1.00 34.25 ? 262 THR A N   1 
ATOM   1440 C  CA  . THR A 1 262 ? 172.028 214.253 298.028 1.00 34.25 ? 262 THR A CA  1 
ATOM   1441 C  C   . THR A 1 262 ? 171.089 213.306 297.301 1.00 34.25 ? 262 THR A C   1 
ATOM   1442 O  O   . THR A 1 262 ? 171.498 212.555 296.413 1.00 34.25 ? 262 THR A O   1 
ATOM   1443 C  CB  . THR A 1 262 ? 171.826 215.693 297.569 1.00 34.25 ? 262 THR A CB  1 
ATOM   1444 O  OG1 . THR A 1 262 ? 170.743 216.281 298.296 1.00 34.25 ? 262 THR A OG1 1 
ATOM   1445 C  CG2 . THR A 1 262 ? 171.515 215.726 296.117 1.00 34.25 ? 262 THR A CG2 1 
ATOM   1446 N  N   . ILE A 1 263 ? 169.828 213.338 297.714 1.00 34.50 ? 263 ILE A N   1 
ATOM   1447 C  CA  . ILE A 1 263 ? 168.766 212.554 297.102 1.00 34.50 ? 263 ILE A CA  1 
ATOM   1448 C  C   . ILE A 1 263 ? 167.769 213.515 296.479 1.00 34.50 ? 263 ILE A C   1 
ATOM   1449 O  O   . ILE A 1 263 ? 167.218 214.382 297.166 1.00 34.50 ? 263 ILE A O   1 
ATOM   1450 C  CB  . ILE A 1 263 ? 168.068 211.641 298.118 1.00 34.50 ? 263 ILE A CB  1 
ATOM   1451 C  CG1 . ILE A 1 263 ? 169.091 210.868 298.941 1.00 34.50 ? 263 ILE A CG1 1 
ATOM   1452 C  CG2 . ILE A 1 263 ? 167.155 210.683 297.413 1.00 34.50 ? 263 ILE A CG2 1 
ATOM   1453 C  CD1 . ILE A 1 263 ? 168.468 210.027 300.014 1.00 34.50 ? 263 ILE A CD1 1 
ATOM   1454 N  N   . LEU A 1 264 ? 167.551 213.366 295.184 1.00 36.72 ? 264 LEU A N   1 
ATOM   1455 C  CA  . LEU A 1 264 ? 166.599 214.171 294.439 1.00 36.72 ? 264 LEU A CA  1 
ATOM   1456 C  C   . LEU A 1 264 ? 165.327 213.357 294.252 1.00 36.72 ? 264 LEU A C   1 
ATOM   1457 O  O   . LEU A 1 264 ? 165.344 212.323 293.584 1.00 36.72 ? 264 LEU A O   1 
ATOM   1458 C  CB  . LEU A 1 264 ? 167.192 214.579 293.094 1.00 36.72 ? 264 LEU A CB  1 
ATOM   1459 C  CG  . LEU A 1 264 ? 166.282 215.307 292.117 1.00 36.72 ? 264 LEU A CG  1 
ATOM   1460 C  CD1 . LEU A 1 264 ? 166.016 216.695 292.613 1.00 36.72 ? 264 LEU A CD1 1 
ATOM   1461 C  CD2 . LEU A 1 264 ? 166.917 215.341 290.752 1.00 36.72 ? 264 LEU A CD2 1 
ATOM   1462 N  N   . ARG A 1 265 ? 164.230 213.828 294.831 1.00 39.16 ? 265 ARG A N   1 
ATOM   1463 C  CA  . ARG A 1 265 ? 162.935 213.165 294.735 1.00 39.16 ? 265 ARG A CA  1 
ATOM   1464 C  C   . ARG A 1 265 ? 162.095 213.892 293.693 1.00 39.16 ? 265 ARG A C   1 
ATOM   1465 O  O   . ARG A 1 265 ? 161.718 215.050 293.886 1.00 39.16 ? 265 ARG A O   1 
ATOM   1466 C  CB  . ARG A 1 265 ? 162.225 213.149 296.081 1.00 39.16 ? 265 ARG A CB  1 
ATOM   1467 C  CG  . ARG A 1 265 ? 163.094 212.735 297.220 1.00 39.16 ? 265 ARG A CG  1 
ATOM   1468 C  CD  . ARG A 1 265 ? 162.369 211.816 298.152 1.00 39.16 ? 265 ARG A CD  1 
ATOM   1469 N  NE  . ARG A 1 265 ? 162.979 211.822 299.474 1.00 39.16 ? 265 ARG A NE  1 
ATOM   1470 C  CZ  . ARG A 1 265 ? 163.824 210.907 299.926 1.00 39.16 ? 265 ARG A CZ  1 
ATOM   1471 N  NH1 . ARG A 1 265 ? 164.194 209.880 299.181 1.00 39.16 ? 265 ARG A NH1 1 
ATOM   1472 N  NH2 . ARG A 1 265 ? 164.305 211.024 301.160 1.00 39.16 ? 265 ARG A NH2 1 
ATOM   1473 N  N   . VAL A 1 266 ? 161.799 213.209 292.597 1.00 41.93 ? 266 VAL A N   1 
ATOM   1474 C  CA  . VAL A 1 266 ? 161.012 213.753 291.504 1.00 41.93 ? 266 VAL A CA  1 
ATOM   1475 C  C   . VAL A 1 266 ? 159.739 212.934 291.399 1.00 41.93 ? 266 VAL A C   1 
ATOM   1476 O  O   . VAL A 1 266 ? 159.798 211.711 291.259 1.00 41.93 ? 266 VAL A O   1 
ATOM   1477 C  CB  . VAL A 1 266 ? 161.795 213.699 290.188 1.00 41.93 ? 266 VAL A CB  1 
ATOM   1478 C  CG1 . VAL A 1 266 ? 160.912 214.059 289.030 1.00 41.93 ? 266 VAL A CG1 1 
ATOM   1479 C  CG2 . VAL A 1 266 ? 162.977 214.616 290.261 1.00 41.93 ? 266 VAL A CG2 1 
ATOM   1480 N  N   . HIS A 1 267 ? 158.590 213.593 291.460 1.00 46.37 ? 267 HIS A N   1 
ATOM   1481 C  CA  . HIS A 1 267 ? 157.342 212.868 291.300 1.00 46.37 ? 267 HIS A CA  1 
ATOM   1482 C  C   . HIS A 1 267 ? 157.221 212.335 289.880 1.00 46.37 ? 267 HIS A C   1 
ATOM   1483 O  O   . HIS A 1 267 ? 157.711 212.936 288.924 1.00 46.37 ? 267 HIS A O   1 
ATOM   1484 C  CB  . HIS A 1 267 ? 156.149 213.748 291.641 1.00 46.37 ? 267 HIS A CB  1 
ATOM   1485 C  CG  . HIS A 1 267 ? 154.961 212.977 292.123 1.00 46.37 ? 267 HIS A CG  1 
ATOM   1486 N  ND1 . HIS A 1 267 ? 154.199 212.188 291.290 1.00 46.37 ? 267 HIS A ND1 1 
ATOM   1487 C  CD2 . HIS A 1 267 ? 154.408 212.869 293.353 1.00 46.37 ? 267 HIS A CD2 1 
ATOM   1488 C  CE1 . HIS A 1 267 ? 153.224 211.631 291.985 1.00 46.37 ? 267 HIS A CE1 1 
ATOM   1489 N  NE2 . HIS A 1 267 ? 153.330 212.026 293.240 1.00 46.37 ? 267 HIS A NE2 1 
ATOM   1490 N  N   . THR A 1 268 ? 156.583 211.172 289.753 1.00 47.11 ? 268 THR A N   1 
ATOM   1491 C  CA  . THR A 1 268 ? 156.500 210.513 288.455 1.00 47.11 ? 268 THR A CA  1 
ATOM   1492 C  C   . THR A 1 268 ? 155.706 211.333 287.450 1.00 47.11 ? 268 THR A C   1 
ATOM   1493 O  O   . THR A 1 268 ? 156.018 211.319 286.254 1.00 47.11 ? 268 THR A O   1 
ATOM   1494 C  CB  . THR A 1 268 ? 155.892 209.123 288.608 1.00 47.11 ? 268 THR A CB  1 
ATOM   1495 O  OG1 . THR A 1 268 ? 156.424 208.499 289.778 1.00 47.11 ? 268 THR A OG1 1 
ATOM   1496 C  CG2 . THR A 1 268 ? 156.255 208.273 287.421 1.00 47.11 ? 268 THR A CG2 1 
ATOM   1497 N  N   . ARG A 1 269 ? 154.681 212.051 287.908 1.00 49.04 ? 269 ARG A N   1 
ATOM   1498 C  CA  . ARG A 1 269 ? 153.920 212.911 287.009 1.00 49.04 ? 269 ARG A CA  1 
ATOM   1499 C  C   . ARG A 1 269 ? 154.793 214.011 286.431 1.00 49.04 ? 269 ARG A C   1 
ATOM   1500 O  O   . ARG A 1 269 ? 154.723 214.306 285.234 1.00 49.04 ? 269 ARG A O   1 
ATOM   1501 C  CB  . ARG A 1 269 ? 152.736 213.517 287.750 1.00 49.04 ? 269 ARG A CB  1 
ATOM   1502 C  CG  . ARG A 1 269 ? 152.040 214.589 286.973 1.00 49.04 ? 269 ARG A CG  1 
ATOM   1503 C  CD  . ARG A 1 269 ? 150.716 214.946 287.588 1.00 49.04 ? 269 ARG A CD  1 
ATOM   1504 N  NE  . ARG A 1 269 ? 150.028 215.944 286.782 1.00 49.04 ? 269 ARG A NE  1 
ATOM   1505 C  CZ  . ARG A 1 269 ? 148.769 215.852 286.387 1.00 49.04 ? 269 ARG A CZ  1 
ATOM   1506 N  NH1 . ARG A 1 269 ? 148.017 214.816 286.714 1.00 49.04 ? 269 ARG A NH1 1 
ATOM   1507 N  NH2 . ARG A 1 269 ? 148.249 216.829 285.654 1.00 49.04 ? 269 ARG A NH2 1 
ATOM   1508 N  N   . VAL A 1 270 ? 155.631 214.620 287.268 1.00 50.39 ? 270 VAL A N   1 
ATOM   1509 C  CA  . VAL A 1 270 ? 156.527 215.682 286.830 1.00 50.39 ? 270 VAL A CA  1 
ATOM   1510 C  C   . VAL A 1 270 ? 157.568 215.159 285.856 1.00 50.39 ? 270 VAL A C   1 
ATOM   1511 O  O   . VAL A 1 270 ? 158.107 215.919 285.047 1.00 50.39 ? 270 VAL A O   1 
ATOM   1512 C  CB  . VAL A 1 270 ? 157.189 216.346 288.042 1.00 50.39 ? 270 VAL A CB  1 
ATOM   1513 C  CG1 . VAL A 1 270 ? 157.692 217.703 287.661 1.00 50.39 ? 270 VAL A CG1 1 
ATOM   1514 C  CG2 . VAL A 1 270 ? 156.198 216.463 289.167 1.00 50.39 ? 270 VAL A CG2 1 
ATOM   1515 N  N   . ALA A 1 271 ? 157.896 213.878 285.931 1.00 50.66 ? 271 ALA A N   1 
ATOM   1516 C  CA  . ALA A 1 271 ? 158.847 213.297 285.001 1.00 50.66 ? 271 ALA A CA  1 
ATOM   1517 C  C   . ALA A 1 271 ? 158.201 212.802 283.721 1.00 50.66 ? 271 ALA A C   1 
ATOM   1518 O  O   . ALA A 1 271 ? 158.893 212.671 282.707 1.00 50.66 ? 271 ALA A O   1 
ATOM   1519 C  CB  . ALA A 1 271 ? 159.577 212.132 285.667 1.00 50.66 ? 271 ALA A CB  1 
ATOM   1520 N  N   . ASP A 1 272 ? 156.897 212.540 283.740 1.00 53.55 ? 272 ASP A N   1 
ATOM   1521 C  CA  . ASP A 1 272 ? 156.191 212.019 282.576 1.00 53.55 ? 272 ASP A CA  1 
ATOM   1522 C  C   . ASP A 1 272 ? 155.638 213.111 281.673 1.00 53.55 ? 272 ASP A C   1 
ATOM   1523 O  O   . ASP A 1 272 ? 155.684 212.981 280.446 1.00 53.55 ? 272 ASP A O   1 
ATOM   1524 C  CB  . ASP A 1 272 ? 155.059 211.106 283.030 1.00 53.55 ? 272 ASP A CB  1 
ATOM   1525 C  CG  . ASP A 1 272 ? 155.553 209.754 283.463 1.00 53.55 ? 272 ASP A CG  1 
ATOM   1526 O  OD1 . ASP A 1 272 ? 156.655 209.361 283.040 1.00 53.55 ? 272 ASP A OD1 1 
ATOM   1527 O  OD2 . ASP A 1 272 ? 154.845 209.082 284.235 1.00 53.55 ? 272 ASP A OD2 1 
ATOM   1528 N  N   . LEU A 1 273 ? 155.133 214.197 282.250 1.00 54.58 ? 273 LEU A N   1 
ATOM   1529 C  CA  . LEU A 1 273 ? 154.458 215.240 281.489 1.00 54.58 ? 273 LEU A CA  1 
ATOM   1530 C  C   . LEU A 1 273 ? 155.375 216.419 281.191 1.00 54.58 ? 273 LEU A C   1 
ATOM   1531 O  O   . LEU A 1 273 ? 155.562 216.784 280.028 1.00 54.58 ? 273 LEU A O   1 
ATOM   1532 C  CB  . LEU A 1 273 ? 153.210 215.705 282.247 1.00 54.58 ? 273 LEU A CB  1 
ATOM   1533 C  CG  . LEU A 1 273 ? 152.286 214.617 282.786 1.00 54.58 ? 273 LEU A CG  1 
ATOM   1534 C  CD1 . LEU A 1 273 ? 151.122 215.223 283.521 1.00 54.58 ? 273 LEU A CD1 1 
ATOM   1535 C  CD2 . LEU A 1 273 ? 151.792 213.763 281.642 1.00 54.58 ? 273 LEU A CD2 1 
ATOM   1536 N  N   . TYR A 1 274 ? 155.959 217.019 282.226 1.00 61.01 ? 274 TYR A N   1 
ATOM   1537 C  CA  . TYR A 1 274 ? 156.764 218.232 282.078 1.00 61.01 ? 274 TYR A CA  1 
ATOM   1538 C  C   . TYR A 1 274 ? 158.173 217.860 281.619 1.00 61.01 ? 274 TYR A C   1 
ATOM   1539 O  O   . TYR A 1 274 ? 159.155 217.962 282.354 1.00 61.01 ? 274 TYR A O   1 
ATOM   1540 C  CB  . TYR A 1 274 ? 156.795 219.008 283.385 1.00 61.01 ? 274 TYR A CB  1 
ATOM   1541 C  CG  . TYR A 1 274 ? 155.433 219.306 283.946 1.00 61.01 ? 274 TYR A CG  1 
ATOM   1542 C  CD1 . TYR A 1 274 ? 154.774 218.391 284.752 1.00 61.01 ? 274 TYR A CD1 1 
ATOM   1543 C  CD2 . TYR A 1 274 ? 154.808 220.510 283.675 1.00 61.01 ? 274 TYR A CD2 1 
ATOM   1544 C  CE1 . TYR A 1 274 ? 153.526 218.659 285.263 1.00 61.01 ? 274 TYR A CE1 1 
ATOM   1545 C  CE2 . TYR A 1 274 ? 153.562 220.794 284.180 1.00 61.01 ? 274 TYR A CE2 1 
ATOM   1546 C  CZ  . TYR A 1 274 ? 152.922 219.864 284.974 1.00 61.01 ? 274 TYR A CZ  1 
ATOM   1547 O  OH  . TYR A 1 274 ? 151.672 220.154 285.476 1.00 61.01 ? 274 TYR A OH  1 
ATOM   1548 N  N   . ASN A 1 275 ? 158.260 217.399 280.370 1.00 66.57 ? 275 ASN A N   1 
ATOM   1549 C  CA  . ASN A 1 275 ? 159.552 217.001 279.827 1.00 66.57 ? 275 ASN A CA  1 
ATOM   1550 C  C   . ASN A 1 275 ? 159.748 217.360 278.358 1.00 66.57 ? 275 ASN A C   1 
ATOM   1551 O  O   . ASN A 1 275 ? 160.752 216.945 277.767 1.00 66.57 ? 275 ASN A O   1 
ATOM   1552 C  CB  . ASN A 1 275 ? 159.786 215.499 280.041 1.00 66.57 ? 275 ASN A CB  1 
ATOM   1553 C  CG  . ASN A 1 275 ? 158.943 214.624 279.135 1.00 66.57 ? 275 ASN A CG  1 
ATOM   1554 O  OD1 . ASN A 1 275 ? 158.216 215.101 278.268 1.00 66.57 ? 275 ASN A OD1 1 
ATOM   1555 N  ND2 . ASN A 1 275 ? 159.041 213.319 279.338 1.00 66.57 ? 275 ASN A ND2 1 
ATOM   1556 N  N   . GLY A 1 276 ? 158.823 218.081 277.737 1.00 74.57 ? 276 GLY A N   1 
ATOM   1557 C  CA  . GLY A 1 276 ? 158.915 218.352 276.323 1.00 74.57 ? 276 GLY A CA  1 
ATOM   1558 C  C   . GLY A 1 276 ? 159.718 219.582 275.940 1.00 74.57 ? 276 GLY A C   1 
ATOM   1559 O  O   . GLY A 1 276 ? 160.775 219.482 275.309 1.00 74.57 ? 276 GLY A O   1 
ATOM   1560 N  N   . PRO A 1 277 ? 159.249 220.769 276.331 1.00 78.43 ? 277 PRO A N   1 
ATOM   1561 C  CA  . PRO A 1 277 ? 160.006 221.992 276.019 1.00 78.43 ? 277 PRO A CA  1 
ATOM   1562 C  C   . PRO A 1 277 ? 161.117 222.283 277.010 1.00 78.43 ? 277 PRO A C   1 
ATOM   1563 O  O   . PRO A 1 277 ? 162.136 222.886 276.659 1.00 78.43 ? 277 PRO A O   1 
ATOM   1564 C  CB  . PRO A 1 277 ? 158.930 223.084 276.055 1.00 78.43 ? 277 PRO A CB  1 
ATOM   1565 C  CG  . PRO A 1 277 ? 157.933 222.569 277.032 1.00 78.43 ? 277 PRO A CG  1 
ATOM   1566 C  CD  . PRO A 1 277 ? 157.911 221.071 276.870 1.00 78.43 ? 277 PRO A CD  1 
ATOM   1567 N  N   . MET A 1 278 ? 160.924 221.863 278.254 1.00 77.48 ? 278 MET A N   1 
ATOM   1568 C  CA  . MET A 1 278 ? 161.979 221.891 279.251 1.00 77.48 ? 278 MET A CA  1 
ATOM   1569 C  C   . MET A 1 278 ? 161.686 220.800 280.265 1.00 77.48 ? 278 MET A C   1 
ATOM   1570 O  O   . MET A 1 278 ? 160.527 220.479 280.534 1.00 77.48 ? 278 MET A O   1 
ATOM   1571 C  CB  . MET A 1 278 ? 162.103 223.267 279.924 1.00 77.48 ? 278 MET A CB  1 
ATOM   1572 C  CG  . MET A 1 278 ? 161.110 223.549 281.044 1.00 77.48 ? 278 MET A CG  1 
ATOM   1573 S  SD  . MET A 1 278 ? 159.377 223.355 280.584 1.00 77.48 ? 278 MET A SD  1 
ATOM   1574 C  CE  . MET A 1 278 ? 159.134 224.793 279.543 1.00 77.48 ? 278 MET A CE  1 
ATOM   1575 N  N   . ASN A 1 279 ? 162.742 220.216 280.810 1.00 67.64 ? 279 ASN A N   1 
ATOM   1576 C  CA  . ASN A 1 279 ? 162.607 219.137 281.775 1.00 67.64 ? 279 ASN A CA  1 
ATOM   1577 C  C   . ASN A 1 279 ? 162.761 219.728 283.164 1.00 67.64 ? 279 ASN A C   1 
ATOM   1578 O  O   . ASN A 1 279 ? 163.859 220.136 283.558 1.00 67.64 ? 279 ASN A O   1 
ATOM   1579 C  CB  . ASN A 1 279 ? 163.645 218.044 281.548 1.00 67.64 ? 279 ASN A CB  1 
ATOM   1580 C  CG  . ASN A 1 279 ? 163.449 217.320 280.253 1.00 67.64 ? 279 ASN A CG  1 
ATOM   1581 O  OD1 . ASN A 1 279 ? 162.803 217.829 279.342 1.00 67.64 ? 279 ASN A OD1 1 
ATOM   1582 N  ND2 . ASN A 1 279 ? 163.994 216.116 280.159 1.00 67.64 ? 279 ASN A ND2 1 
ATOM   1583 N  N   . GLN A 1 280 ? 161.654 219.777 283.900 1.00 62.94 ? 280 GLN A N   1 
ATOM   1584 C  CA  . GLN A 1 280 ? 161.713 220.191 285.292 1.00 62.94 ? 280 GLN A CA  1 
ATOM   1585 C  C   . GLN A 1 280 ? 162.514 219.190 286.115 1.00 62.94 ? 280 GLN A C   1 
ATOM   1586 O  O   . GLN A 1 280 ? 163.086 219.551 287.146 1.00 62.94 ? 280 GLN A O   1 
ATOM   1587 C  CB  . GLN A 1 280 ? 160.305 220.384 285.845 1.00 62.94 ? 280 GLN A CB  1 
ATOM   1588 C  CG  . GLN A 1 280 ? 160.274 220.985 287.235 1.00 62.94 ? 280 GLN A CG  1 
ATOM   1589 C  CD  . GLN A 1 280 ? 158.888 220.992 287.832 1.00 62.94 ? 280 GLN A CD  1 
ATOM   1590 O  OE1 . GLN A 1 280 ? 157.894 221.101 287.116 1.00 62.94 ? 280 GLN A OE1 1 
ATOM   1591 N  NE2 . GLN A 1 280 ? 158.811 220.856 289.150 1.00 62.94 ? 280 GLN A NE2 1 
ATOM   1592 N  N   . THR A 1 281 ? 162.571 217.935 285.671 1.00 58.86 ? 281 THR A N   1 
ATOM   1593 C  CA  . THR A 1 281 ? 163.520 216.983 286.239 1.00 58.86 ? 281 THR A CA  1 
ATOM   1594 C  C   . THR A 1 281 ? 164.963 217.406 285.982 1.00 58.86 ? 281 THR A C   1 
ATOM   1595 O  O   . THR A 1 281 ? 165.786 217.417 286.901 1.00 58.86 ? 281 THR A O   1 
ATOM   1596 C  CB  . THR A 1 281 ? 163.271 215.588 285.673 1.00 58.86 ? 281 THR A CB  1 
ATOM   1597 O  OG1 . THR A 1 281 ? 161.979 215.133 286.084 1.00 58.86 ? 281 THR A OG1 1 
ATOM   1598 C  CG2 . THR A 1 281 ? 164.331 214.618 286.160 1.00 58.86 ? 281 THR A CG2 1 
ATOM   1599 N  N   . GLU A 1 282 ? 165.285 217.783 284.747 1.00 58.78 ? 282 GLU A N   1 
ATOM   1600 C  CA  . GLU A 1 282 ? 166.638 218.250 284.453 1.00 58.78 ? 282 GLU A CA  1 
ATOM   1601 C  C   . GLU A 1 282 ? 166.938 219.589 285.117 1.00 58.78 ? 282 GLU A C   1 
ATOM   1602 O  O   . GLU A 1 282 ? 168.068 219.826 285.549 1.00 58.78 ? 282 GLU A O   1 
ATOM   1603 C  CB  . GLU A 1 282 ? 166.853 218.343 282.949 1.00 58.78 ? 282 GLU A CB  1 
ATOM   1604 C  CG  . GLU A 1 282 ? 168.305 218.288 282.549 1.00 58.78 ? 282 GLU A CG  1 
ATOM   1605 C  CD  . GLU A 1 282 ? 168.781 216.878 282.281 1.00 58.78 ? 282 GLU A CD  1 
ATOM   1606 O  OE1 . GLU A 1 282 ? 168.130 215.925 282.757 1.00 58.78 ? 282 GLU A OE1 1 
ATOM   1607 O  OE2 . GLU A 1 282 ? 169.804 216.722 281.585 1.00 58.78 ? 282 GLU A OE2 1 
ATOM   1608 N  N   . GLU A 1 283 ? 165.958 220.482 285.204 1.00 55.99 ? 283 GLU A N   1 
ATOM   1609 C  CA  . GLU A 1 283 ? 166.202 221.740 285.901 1.00 55.99 ? 283 GLU A CA  1 
ATOM   1610 C  C   . GLU A 1 283 ? 166.391 221.524 287.397 1.00 55.99 ? 283 GLU A C   1 
ATOM   1611 O  O   . GLU A 1 283 ? 167.248 222.162 288.018 1.00 55.99 ? 283 GLU A O   1 
ATOM   1612 C  CB  . GLU A 1 283 ? 165.066 222.722 285.642 1.00 55.99 ? 283 GLU A CB  1 
ATOM   1613 C  CG  . GLU A 1 283 ? 165.490 224.174 285.781 1.00 55.99 ? 283 GLU A CG  1 
ATOM   1614 C  CD  . GLU A 1 283 ? 166.383 224.635 284.648 1.00 55.99 ? 283 GLU A CD  1 
ATOM   1615 O  OE1 . GLU A 1 283 ? 166.152 224.218 283.494 1.00 55.99 ? 283 GLU A OE1 1 
ATOM   1616 O  OE2 . GLU A 1 283 ? 167.321 225.413 284.915 1.00 55.99 ? 283 GLU A OE2 1 
ATOM   1617 N  N   . GLN A 1 284 ? 165.607 220.630 287.995 1.00 50.61 ? 284 GLN A N   1 
ATOM   1618 C  CA  . GLN A 1 284 ? 165.806 220.290 289.398 1.00 50.61 ? 284 GLN A CA  1 
ATOM   1619 C  C   . GLN A 1 284 ? 167.159 219.627 289.613 1.00 50.61 ? 284 GLN A C   1 
ATOM   1620 O  O   . GLN A 1 284 ? 167.812 219.846 290.638 1.00 50.61 ? 284 GLN A O   1 
ATOM   1621 C  CB  . GLN A 1 284 ? 164.674 219.390 289.878 1.00 50.61 ? 284 GLN A CB  1 
ATOM   1622 C  CG  . GLN A 1 284 ? 164.237 219.670 291.299 1.00 50.61 ? 284 GLN A CG  1 
ATOM   1623 C  CD  . GLN A 1 284 ? 163.113 218.764 291.729 1.00 50.61 ? 284 GLN A CD  1 
ATOM   1624 O  OE1 . GLN A 1 284 ? 162.748 217.841 291.010 1.00 50.61 ? 284 GLN A OE1 1 
ATOM   1625 N  NE2 . GLN A 1 284 ? 162.577 219.003 292.917 1.00 50.61 ? 284 GLN A NE2 1 
ATOM   1626 N  N   . LEU A 1 285 ? 167.589 218.800 288.666 1.00 47.30 ? 285 LEU A N   1 
ATOM   1627 C  CA  . LEU A 1 285 ? 168.920 218.216 288.747 1.00 47.30 ? 285 LEU A CA  1 
ATOM   1628 C  C   . LEU A 1 285 ? 169.998 219.284 288.665 1.00 47.30 ? 285 LEU A C   1 
ATOM   1629 O  O   . LEU A 1 285 ? 171.007 219.210 289.370 1.00 47.30 ? 285 LEU A O   1 
ATOM   1630 C  CB  . LEU A 1 285 ? 169.108 217.192 287.637 1.00 47.30 ? 285 LEU A CB  1 
ATOM   1631 C  CG  . LEU A 1 285 ? 170.391 216.391 287.755 1.00 47.30 ? 285 LEU A CG  1 
ATOM   1632 C  CD1 . LEU A 1 285 ? 170.251 215.427 288.892 1.00 47.30 ? 285 LEU A CD1 1 
ATOM   1633 C  CD2 . LEU A 1 285 ? 170.646 215.664 286.467 1.00 47.30 ? 285 LEU A CD2 1 
ATOM   1634 N  N   . ARG A 1 286 ? 169.809 220.281 287.805 1.00 46.43 ? 286 ARG A N   1 
ATOM   1635 C  CA  . ARG A 1 286 ? 170.771 221.372 287.708 1.00 46.43 ? 286 ARG A CA  1 
ATOM   1636 C  C   . ARG A 1 286 ? 170.851 222.150 289.016 1.00 46.43 ? 286 ARG A C   1 
ATOM   1637 O  O   . ARG A 1 286 ? 171.941 222.519 289.466 1.00 46.43 ? 286 ARG A O   1 
ATOM   1638 C  CB  . ARG A 1 286 ? 170.384 222.290 286.554 1.00 46.43 ? 286 ARG A CB  1 
ATOM   1639 C  CG  . ARG A 1 286 ? 171.547 223.002 285.897 1.00 46.43 ? 286 ARG A CG  1 
ATOM   1640 C  CD  . ARG A 1 286 ? 171.082 224.216 285.110 1.00 46.43 ? 286 ARG A CD  1 
ATOM   1641 N  NE  . ARG A 1 286 ? 170.067 224.966 285.837 1.00 46.43 ? 286 ARG A NE  1 
ATOM   1642 C  CZ  . ARG A 1 286 ? 170.333 225.965 286.666 1.00 46.43 ? 286 ARG A CZ  1 
ATOM   1643 N  NH1 . ARG A 1 286 ? 171.573 226.367 286.888 1.00 46.43 ? 286 ARG A NH1 1 
ATOM   1644 N  NH2 . ARG A 1 286 ? 169.331 226.570 287.296 1.00 46.43 ? 286 ARG A NH2 1 
ATOM   1645 N  N   . LEU A 1 287 ? 169.704 222.418 289.633 1.00 44.04 ? 287 LEU A N   1 
ATOM   1646 C  CA  . LEU A 1 287 ? 169.709 223.078 290.935 1.00 44.04 ? 287 LEU A CA  1 
ATOM   1647 C  C   . LEU A 1 287 ? 170.413 222.233 291.987 1.00 44.04 ? 287 LEU A C   1 
ATOM   1648 O  O   . LEU A 1 287 ? 171.156 222.759 292.823 1.00 44.04 ? 287 LEU A O   1 
ATOM   1649 C  CB  . LEU A 1 287 ? 168.280 223.372 291.376 1.00 44.04 ? 287 LEU A CB  1 
ATOM   1650 C  CG  . LEU A 1 287 ? 167.745 224.768 291.096 1.00 44.04 ? 287 LEU A CG  1 
ATOM   1651 C  CD1 . LEU A 1 287 ? 167.457 224.932 289.628 1.00 44.04 ? 287 LEU A CD1 1 
ATOM   1652 C  CD2 . LEU A 1 287 ? 166.504 225.013 291.922 1.00 44.04 ? 287 LEU A CD2 1 
ATOM   1653 N  N   . THR A 1 288 ? 170.183 220.921 291.969 1.00 40.04 ? 288 THR A N   1 
ATOM   1654 C  CA  . THR A 1 288 ? 170.870 220.021 292.891 1.00 40.04 ? 288 THR A CA  1 
ATOM   1655 C  C   . THR A 1 288 ? 172.381 220.057 292.698 1.00 40.04 ? 288 THR A C   1 
ATOM   1656 O  O   . THR A 1 288 ? 173.138 220.091 293.671 1.00 40.04 ? 288 THR A O   1 
ATOM   1657 C  CB  . THR A 1 288 ? 170.337 218.604 292.709 1.00 40.04 ? 288 THR A CB  1 
ATOM   1658 O  OG1 . THR A 1 288 ? 169.068 218.488 293.359 1.00 40.04 ? 288 THR A OG1 1 
ATOM   1659 C  CG2 . THR A 1 288 ? 171.282 217.605 293.283 1.00 40.04 ? 288 THR A CG2 1 
ATOM   1660 N  N   . ILE A 1 289 ? 172.834 220.054 291.449 1.00 38.60 ? 289 ILE A N   1 
ATOM   1661 C  CA  . ILE A 1 289 ? 174.264 220.100 291.164 1.00 38.60 ? 289 ILE A CA  1 
ATOM   1662 C  C   . ILE A 1 289 ? 174.864 221.408 291.652 1.00 38.60 ? 289 ILE A C   1 
ATOM   1663 O  O   . ILE A 1 289 ? 175.962 221.429 292.215 1.00 38.60 ? 289 ILE A O   1 
ATOM   1664 C  CB  . ILE A 1 289 ? 174.515 219.883 289.667 1.00 38.60 ? 289 ILE A CB  1 
ATOM   1665 C  CG1 . ILE A 1 289 ? 173.996 218.513 289.259 1.00 38.60 ? 289 ILE A CG1 1 
ATOM   1666 C  CG2 . ILE A 1 289 ? 175.985 219.996 289.366 1.00 38.60 ? 289 ILE A CG2 1 
ATOM   1667 C  CD1 . ILE A 1 289 ? 174.033 218.272 287.791 1.00 38.60 ? 289 ILE A CD1 1 
ATOM   1668 N  N   . GLU A 1 290 ? 174.160 222.521 291.442 1.00 38.50 ? 290 GLU A N   1 
ATOM   1669 C  CA  . GLU A 1 290 ? 174.655 223.809 291.919 1.00 38.50 ? 290 GLU A CA  1 
ATOM   1670 C  C   . GLU A 1 290 ? 174.760 223.826 293.435 1.00 38.50 ? 290 GLU A C   1 
ATOM   1671 O  O   . GLU A 1 290 ? 175.735 224.344 293.989 1.00 38.50 ? 290 GLU A O   1 
ATOM   1672 C  CB  . GLU A 1 290 ? 173.753 224.939 291.437 1.00 38.50 ? 290 GLU A CB  1 
ATOM   1673 C  CG  . GLU A 1 290 ? 173.861 225.240 289.955 1.00 38.50 ? 290 GLU A CG  1 
ATOM   1674 C  CD  . GLU A 1 290 ? 175.156 224.745 289.342 1.00 38.50 ? 290 GLU A CD  1 
ATOM   1675 O  OE1 . GLU A 1 290 ? 176.190 225.427 289.486 1.00 38.50 ? 290 GLU A OE1 1 
ATOM   1676 O  OE2 . GLU A 1 290 ? 175.135 223.677 288.697 1.00 38.50 ? 290 GLU A OE2 1 
ATOM   1677 N  N   . ALA A 1 291 ? 173.769 223.271 294.126 1.00 33.38 ? 291 ALA A N   1 
ATOM   1678 C  CA  . ALA A 1 291 ? 173.838 223.198 295.582 1.00 33.38 ? 291 ALA A CA  1 
ATOM   1679 C  C   . ALA A 1 291 ? 175.003 222.325 296.036 1.00 33.38 ? 291 ALA A C   1 
ATOM   1680 O  O   . ALA A 1 291 ? 175.659 222.624 297.040 1.00 33.38 ? 291 ALA A O   1 
ATOM   1681 C  CB  . ALA A 1 291 ? 172.522 222.676 296.141 1.00 33.38 ? 291 ALA A CB  1 
ATOM   1682 N  N   . LEU A 1 292 ? 175.246 221.216 295.338 1.00 32.59 ? 292 LEU A N   1 
ATOM   1683 C  CA  . LEU A 1 292 ? 176.375 220.356 295.682 1.00 32.59 ? 292 LEU A CA  1 
ATOM   1684 C  C   . LEU A 1 292 ? 177.698 221.076 295.492 1.00 32.59 ? 292 LEU A C   1 
ATOM   1685 O  O   . LEU A 1 292 ? 178.607 220.933 296.308 1.00 32.59 ? 292 LEU A O   1 
ATOM   1686 C  CB  . LEU A 1 292 ? 176.362 219.083 294.843 1.00 32.59 ? 292 LEU A CB  1 
ATOM   1687 C  CG  . LEU A 1 292 ? 175.349 218.026 295.250 1.00 32.59 ? 292 LEU A CG  1 
ATOM   1688 C  CD1 . LEU A 1 292 ? 175.687 216.745 294.555 1.00 32.59 ? 292 LEU A CD1 1 
ATOM   1689 C  CD2 . LEU A 1 292 ? 175.328 217.856 296.745 1.00 32.59 ? 292 LEU A CD2 1 
ATOM   1690 N  N   . ARG A 1 293 ? 177.826 221.851 294.419 1.00 31.88 ? 293 ARG A N   1 
ATOM   1691 C  CA  . ARG A 1 293 ? 179.054 222.606 294.181 1.00 31.88 ? 293 ARG A CA  1 
ATOM   1692 C  C   . ARG A 1 293 ? 179.249 223.689 295.237 1.00 31.88 ? 293 ARG A C   1 
ATOM   1693 O  O   . ARG A 1 293 ? 180.376 223.949 295.675 1.00 31.88 ? 293 ARG A O   1 
ATOM   1694 C  CB  . ARG A 1 293 ? 179.010 223.203 292.785 1.00 31.88 ? 293 ARG A CB  1 
ATOM   1695 C  CG  . ARG A 1 293 ? 179.049 222.179 291.688 1.00 31.88 ? 293 ARG A CG  1 
ATOM   1696 C  CD  . ARG A 1 293 ? 180.439 221.993 291.190 1.00 31.88 ? 293 ARG A CD  1 
ATOM   1697 N  NE  . ARG A 1 293 ? 180.576 220.857 290.289 1.00 31.88 ? 293 ARG A NE  1 
ATOM   1698 C  CZ  . ARG A 1 293 ? 180.819 219.614 290.676 1.00 31.88 ? 293 ARG A CZ  1 
ATOM   1699 N  NH1 . ARG A 1 293 ? 180.951 219.304 291.952 1.00 31.88 ? 293 ARG A NH1 1 
ATOM   1700 N  NH2 . ARG A 1 293 ? 180.961 218.666 289.757 1.00 31.88 ? 293 ARG A NH2 1 
ATOM   1701 N  N   . GLU A 1 294 ? 178.169 224.344 295.644 1.00 32.72 ? 294 GLU A N   1 
ATOM   1702 C  CA  . GLU A 1 294 ? 178.271 225.323 296.718 1.00 32.72 ? 294 GLU A CA  1 
ATOM   1703 C  C   . GLU A 1 294 ? 178.717 224.663 298.014 1.00 32.72 ? 294 GLU A C   1 
ATOM   1704 O  O   . GLU A 1 294 ? 179.529 225.222 298.756 1.00 32.72 ? 294 GLU A O   1 
ATOM   1705 C  CB  . GLU A 1 294 ? 176.944 226.045 296.910 1.00 32.72 ? 294 GLU A CB  1 
ATOM   1706 C  CG  . GLU A 1 294 ? 176.550 226.904 295.737 1.00 32.72 ? 294 GLU A CG  1 
ATOM   1707 C  CD  . GLU A 1 294 ? 177.400 228.153 295.618 1.00 32.72 ? 294 GLU A CD  1 
ATOM   1708 O  OE1 . GLU A 1 294 ? 177.580 228.850 296.635 1.00 32.72 ? 294 GLU A OE1 1 
ATOM   1709 O  OE2 . GLU A 1 294 ? 177.894 228.432 294.507 1.00 32.72 ? 294 GLU A OE2 1 
ATOM   1710 N  N   . ARG A 1 295 ? 178.182 223.480 298.316 1.00 31.08 ? 295 ARG A N   1 
ATOM   1711 C  CA  . ARG A 1 295 ? 178.619 222.746 299.502 1.00 31.08 ? 295 ARG A CA  1 
ATOM   1712 C  C   . ARG A 1 295 ? 180.076 222.318 299.390 1.00 31.08 ? 295 ARG A C   1 
ATOM   1713 O  O   . ARG A 1 295 ? 180.805 222.306 300.385 1.00 31.08 ? 295 ARG A O   1 
ATOM   1714 C  CB  . ARG A 1 295 ? 177.728 221.533 299.728 1.00 31.08 ? 295 ARG A CB  1 
ATOM   1715 C  CG  . ARG A 1 295 ? 177.557 221.186 301.186 1.00 31.08 ? 295 ARG A CG  1 
ATOM   1716 C  CD  . ARG A 1 295 ? 177.027 219.788 301.365 1.00 31.08 ? 295 ARG A CD  1 
ATOM   1717 N  NE  . ARG A 1 295 ? 175.794 219.583 300.619 1.00 31.08 ? 295 ARG A NE  1 
ATOM   1718 C  CZ  . ARG A 1 295 ? 175.209 218.406 300.460 1.00 31.08 ? 295 ARG A CZ  1 
ATOM   1719 N  NH1 . ARG A 1 295 ? 175.720 217.307 300.986 1.00 31.08 ? 295 ARG A NH1 1 
ATOM   1720 N  NH2 . ARG A 1 295 ? 174.093 218.329 299.742 1.00 31.08 ? 295 ARG A NH2 1 
ATOM   1721 N  N   . GLN A 1 296 ? 180.510 221.946 298.191 1.00 27.87 ? 296 GLN A N   1 
ATOM   1722 C  CA  . GLN A 1 296 ? 181.907 221.603 297.963 1.00 27.87 ? 296 GLN A CA  1 
ATOM   1723 C  C   . GLN A 1 296 ? 182.809 222.774 298.301 1.00 27.87 ? 296 GLN A C   1 
ATOM   1724 O  O   . GLN A 1 296 ? 183.827 222.611 298.972 1.00 27.87 ? 296 GLN A O   1 
ATOM   1725 C  CB  . GLN A 1 296 ? 182.104 221.206 296.508 1.00 27.87 ? 296 GLN A CB  1 
ATOM   1726 C  CG  . GLN A 1 296 ? 181.927 219.762 296.227 1.00 27.87 ? 296 GLN A CG  1 
ATOM   1727 C  CD  . GLN A 1 296 ? 182.486 219.381 294.897 1.00 27.87 ? 296 GLN A CD  1 
ATOM   1728 O  OE1 . GLN A 1 296 ? 182.466 218.223 294.515 1.00 27.87 ? 296 GLN A OE1 1 
ATOM   1729 N  NE2 . GLN A 1 296 ? 183.006 220.350 294.184 1.00 27.87 ? 296 GLN A NE2 1 
ATOM   1730 N  N   . GLU A 1 297 ? 182.457 223.967 297.824 1.00 29.04 ? 297 GLU A N   1 
ATOM   1731 C  CA  . GLU A 1 297 ? 183.260 225.152 298.125 1.00 29.04 ? 297 GLU A CA  1 
ATOM   1732 C  C   . GLU A 1 297 ? 183.250 225.472 299.615 1.00 29.04 ? 297 GLU A C   1 
ATOM   1733 O  O   . GLU A 1 297 ? 184.296 225.773 300.208 1.00 29.04 ? 297 GLU A O   1 
ATOM   1734 C  CB  . GLU A 1 297 ? 182.742 226.337 297.322 1.00 29.04 ? 297 GLU A CB  1 
ATOM   1735 C  CG  . GLU A 1 297 ? 183.408 227.631 297.649 1.00 29.04 ? 297 GLU A CG  1 
ATOM   1736 C  CD  . GLU A 1 297 ? 184.508 227.976 296.696 1.00 29.04 ? 297 GLU A CD  1 
ATOM   1737 O  OE1 . GLU A 1 297 ? 184.774 227.170 295.789 1.00 29.04 ? 297 GLU A OE1 1 
ATOM   1738 O  OE2 . GLU A 1 297 ? 185.106 229.061 296.854 1.00 29.04 ? 297 GLU A OE2 1 
ATOM   1739 N  N   . HIS A 1 298 ? 182.083 225.392 300.243 1.00 27.37 ? 298 HIS A N   1 
ATOM   1740 C  CA  . HIS A 1 298 ? 181.993 225.697 301.662 1.00 27.37 ? 298 HIS A CA  1 
ATOM   1741 C  C   . HIS A 1 298 ? 182.824 224.734 302.488 1.00 27.37 ? 298 HIS A C   1 
ATOM   1742 O  O   . HIS A 1 298 ? 183.410 225.124 303.499 1.00 27.37 ? 298 HIS A O   1 
ATOM   1743 C  CB  . HIS A 1 298 ? 180.538 225.661 302.114 1.00 27.37 ? 298 HIS A CB  1 
ATOM   1744 C  CG  . HIS A 1 298 ? 180.344 226.015 303.553 1.00 27.37 ? 298 HIS A CG  1 
ATOM   1745 N  ND1 . HIS A 1 298 ? 180.511 225.104 304.570 1.00 27.37 ? 298 HIS A ND1 1 
ATOM   1746 C  CD2 . HIS A 1 298 ? 180.001 227.180 304.146 1.00 27.37 ? 298 HIS A CD2 1 
ATOM   1747 C  CE1 . HIS A 1 298 ? 180.276 225.691 305.728 1.00 27.37 ? 298 HIS A CE1 1 
ATOM   1748 N  NE2 . HIS A 1 298 ? 179.968 226.953 305.498 1.00 27.37 ? 298 HIS A NE2 1 
ATOM   1749 N  N   . GLU A 1 299 ? 182.876 223.465 302.085 1.00 27.47 ? 299 GLU A N   1 
ATOM   1750 C  CA  . GLU A 1 299 ? 183.692 222.488 302.797 1.00 27.47 ? 299 GLU A CA  1 
ATOM   1751 C  C   . GLU A 1 299 ? 185.174 222.686 302.520 1.00 27.47 ? 299 GLU A C   1 
ATOM   1752 O  O   . GLU A 1 299 ? 185.996 222.573 303.428 1.00 27.47 ? 299 GLU A O   1 
ATOM   1753 C  CB  . GLU A 1 299 ? 183.261 221.081 302.409 1.00 27.47 ? 299 GLU A CB  1 
ATOM   1754 C  CG  . GLU A 1 299 ? 182.032 220.587 303.131 1.00 27.47 ? 299 GLU A CG  1 
ATOM   1755 C  CD  . GLU A 1 299 ? 182.112 220.738 304.632 1.00 27.47 ? 299 GLU A CD  1 
ATOM   1756 O  OE1 . GLU A 1 299 ? 182.647 219.826 305.289 1.00 27.47 ? 299 GLU A OE1 1 
ATOM   1757 O  OE2 . GLU A 1 299 ? 181.627 221.758 305.162 1.00 27.47 ? 299 GLU A OE2 1 
ATOM   1758 N  N   . LEU A 1 300 ? 185.539 222.985 301.277 1.00 26.00 ? 300 LEU A N   1 
ATOM   1759 C  CA  . LEU A 1 300 ? 186.938 223.248 300.965 1.00 26.00 ? 300 LEU A CA  1 
ATOM   1760 C  C   . LEU A 1 300 ? 187.479 224.408 301.779 1.00 26.00 ? 300 LEU A C   1 
ATOM   1761 O  O   . LEU A 1 300 ? 188.674 224.454 302.075 1.00 26.00 ? 300 LEU A O   1 
ATOM   1762 C  CB  . LEU A 1 300 ? 187.089 223.552 299.481 1.00 26.00 ? 300 LEU A CB  1 
ATOM   1763 C  CG  . LEU A 1 300 ? 187.076 222.391 298.502 1.00 26.00 ? 300 LEU A CG  1 
ATOM   1764 C  CD1 . LEU A 1 300 ? 186.963 222.931 297.106 1.00 26.00 ? 300 LEU A CD1 1 
ATOM   1765 C  CD2 . LEU A 1 300 ? 188.335 221.576 298.645 1.00 26.00 ? 300 LEU A CD2 1 
ATOM   1766 N  N   . ILE A 1 301 ? 186.629 225.364 302.127 1.00 24.86 ? 301 ILE A N   1 
ATOM   1767 C  CA  . ILE A 1 301 ? 187.068 226.505 302.927 1.00 24.86 ? 301 ILE A CA  1 
ATOM   1768 C  C   . ILE A 1 301 ? 186.987 226.214 304.419 1.00 24.86 ? 301 ILE A C   1 
ATOM   1769 O  O   . ILE A 1 301 ? 187.937 226.462 305.159 1.00 24.86 ? 301 ILE A O   1 
ATOM   1770 C  CB  . ILE A 1 301 ? 186.254 227.762 302.561 1.00 24.86 ? 301 ILE A CB  1 
ATOM   1771 C  CG1 . ILE A 1 301 ? 186.532 228.176 301.127 1.00 24.86 ? 301 ILE A CG1 1 
ATOM   1772 C  CG2 . ILE A 1 301 ? 186.626 228.909 303.464 1.00 24.86 ? 301 ILE A CG2 1 
ATOM   1773 C  CD1 . ILE A 1 301 ? 187.869 228.804 300.953 1.00 24.86 ? 301 ILE A CD1 1 
ATOM   1774 N  N   . ASN A 1 302 ? 185.878 225.651 304.894 1.00 27.24 ? 302 ASN A N   1 
ATOM   1775 C  CA  . ASN A 1 302 ? 185.552 225.637 306.314 1.00 27.24 ? 302 ASN A CA  1 
ATOM   1776 C  C   . ASN A 1 302 ? 185.610 224.269 306.973 1.00 27.24 ? 302 ASN A C   1 
ATOM   1777 O  O   . ASN A 1 302 ? 185.407 224.187 308.186 1.00 27.24 ? 302 ASN A O   1 
ATOM   1778 C  CB  . ASN A 1 302 ? 184.150 226.200 306.539 1.00 27.24 ? 302 ASN A CB  1 
ATOM   1779 C  CG  . ASN A 1 302 ? 184.108 227.685 306.473 1.00 27.24 ? 302 ASN A CG  1 
ATOM   1780 O  OD1 . ASN A 1 302 ? 184.233 228.358 307.486 1.00 27.24 ? 302 ASN A OD1 1 
ATOM   1781 N  ND2 . ASN A 1 302 ? 183.888 228.217 305.286 1.00 27.24 ? 302 ASN A ND2 1 
ATOM   1782 N  N   . ASN A 1 303 ? 185.846 223.198 306.230 1.00 27.01 ? 303 ASN A N   1 
ATOM   1783 C  CA  . ASN A 1 303 ? 185.870 221.890 306.857 1.00 27.01 ? 303 ASN A CA  1 
ATOM   1784 C  C   . ASN A 1 303 ? 187.039 221.812 307.827 1.00 27.01 ? 303 ASN A C   1 
ATOM   1785 O  O   . ASN A 1 303 ? 188.019 222.546 307.715 1.00 27.01 ? 303 ASN A O   1 
ATOM   1786 C  CB  . ASN A 1 303 ? 185.991 220.798 305.803 1.00 27.01 ? 303 ASN A CB  1 
ATOM   1787 C  CG  . ASN A 1 303 ? 185.748 219.432 306.349 1.00 27.01 ? 303 ASN A CG  1 
ATOM   1788 O  OD1 . ASN A 1 303 ? 186.342 219.038 307.336 1.00 27.01 ? 303 ASN A OD1 1 
ATOM   1789 N  ND2 . ASN A 1 303 ? 184.904 218.680 305.686 1.00 27.01 ? 303 ASN A ND2 1 
ATOM   1790 N  N   . ARG A 1 304 ? 186.926 220.917 308.800 1.00 28.54 ? 304 ARG A N   1 
ATOM   1791 C  CA  . ARG A 1 304 ? 187.922 220.844 309.858 1.00 28.54 ? 304 ARG A CA  1 
ATOM   1792 C  C   . ARG A 1 304 ? 189.040 219.866 309.535 1.00 28.54 ? 304 ARG A C   1 
ATOM   1793 O  O   . ARG A 1 304 ? 190.211 220.170 309.761 1.00 28.54 ? 304 ARG A O   1 
ATOM   1794 C  CB  . ARG A 1 304 ? 187.253 220.471 311.172 1.00 28.54 ? 304 ARG A CB  1 
ATOM   1795 C  CG  . ARG A 1 304 ? 186.262 221.490 311.638 1.00 28.54 ? 304 ARG A CG  1 
ATOM   1796 C  CD  . ARG A 1 304 ? 186.159 221.481 313.137 1.00 28.54 ? 304 ARG A CD  1 
ATOM   1797 N  NE  . ARG A 1 304 ? 187.352 222.001 313.788 1.00 28.54 ? 304 ARG A NE  1 
ATOM   1798 C  CZ  . ARG A 1 304 ? 187.361 223.033 314.617 1.00 28.54 ? 304 ARG A CZ  1 
ATOM   1799 N  NH1 . ARG A 1 304 ? 186.254 223.688 314.915 1.00 28.54 ? 304 ARG A NH1 1 
ATOM   1800 N  NH2 . ARG A 1 304 ? 188.507 223.401 315.180 1.00 28.54 ? 304 ARG A NH2 1 
ATOM   1801 N  N   . GLU A 1 305 ? 188.701 218.676 309.054 1.00 28.18 ? 305 GLU A N   1 
ATOM   1802 C  CA  . GLU A 1 305 ? 189.717 217.697 308.697 1.00 28.18 ? 305 GLU A CA  1 
ATOM   1803 C  C   . GLU A 1 305 ? 190.587 218.229 307.571 1.00 28.18 ? 305 GLU A C   1 
ATOM   1804 O  O   . GLU A 1 305 ? 191.775 218.485 307.761 1.00 28.18 ? 305 GLU A O   1 
ATOM   1805 C  CB  . GLU A 1 305 ? 189.060 216.384 308.288 1.00 28.18 ? 305 GLU A CB  1 
ATOM   1806 C  CG  . GLU A 1 305 ? 188.489 215.598 309.451 1.00 28.18 ? 305 GLU A CG  1 
ATOM   1807 C  CD  . GLU A 1 305 ? 187.112 216.070 309.869 1.00 28.18 ? 305 GLU A CD  1 
ATOM   1808 O  OE1 . GLU A 1 305 ? 186.231 216.200 308.994 1.00 28.18 ? 305 GLU A OE1 1 
ATOM   1809 O  OE2 . GLU A 1 305 ? 186.906 216.305 311.077 1.00 28.18 ? 305 GLU A OE2 1 
ATOM   1810 N  N   . PHE A 1 306 ? 190.005 218.420 306.405 1.00 26.47 ? 306 PHE A N   1 
ATOM   1811 C  CA  . PHE A 1 306 ? 190.637 219.164 305.334 1.00 26.47 ? 306 PHE A CA  1 
ATOM   1812 C  C   . PHE A 1 306 ? 189.999 220.540 305.253 1.00 26.47 ? 306 PHE A C   1 
ATOM   1813 O  O   . PHE A 1 306 ? 188.995 220.822 305.895 1.00 26.47 ? 306 PHE A O   1 
ATOM   1814 C  CB  . PHE A 1 306 ? 190.508 218.417 304.007 1.00 26.47 ? 306 PHE A CB  1 
ATOM   1815 C  CG  . PHE A 1 306 ? 189.129 218.452 303.420 1.00 26.47 ? 306 PHE A CG  1 
ATOM   1816 C  CD1 . PHE A 1 306 ? 188.127 217.660 303.925 1.00 26.47 ? 306 PHE A CD1 1 
ATOM   1817 C  CD2 . PHE A 1 306 ? 188.842 219.266 302.347 1.00 26.47 ? 306 PHE A CD2 1 
ATOM   1818 C  CE1 . PHE A 1 306 ? 186.873 217.699 303.388 1.00 26.47 ? 306 PHE A CE1 1 
ATOM   1819 C  CE2 . PHE A 1 306 ? 187.588 219.297 301.810 1.00 26.47 ? 306 PHE A CE2 1 
ATOM   1820 C  CZ  . PHE A 1 306 ? 186.608 218.511 302.328 1.00 26.47 ? 306 PHE A CZ  1 
ATOM   1821 N  N   . GLY A 1 307 ? 190.633 221.431 304.531 1.00 23.29 ? 307 GLY A N   1 
ATOM   1822 C  CA  . GLY A 1 307 ? 190.102 222.766 304.464 1.00 23.29 ? 307 GLY A CA  1 
ATOM   1823 C  C   . GLY A 1 307 ? 191.160 223.768 304.806 1.00 23.29 ? 307 GLY A C   1 
ATOM   1824 O  O   . GLY A 1 307 ? 191.778 223.700 305.864 1.00 23.29 ? 307 GLY A O   1 
ATOM   1825 N  N   . LEU A 1 308 ? 191.317 224.749 303.928 1.00 22.36 ? 308 LEU A N   1 
ATOM   1826 C  CA  . LEU A 1 308 ? 192.452 225.651 303.998 1.00 22.36 ? 308 LEU A CA  1 
ATOM   1827 C  C   . LEU A 1 308 ? 192.452 226.487 305.264 1.00 22.36 ? 308 LEU A C   1 
ATOM   1828 O  O   . LEU A 1 308 ? 193.518 226.795 305.798 1.00 22.36 ? 308 LEU A O   1 
ATOM   1829 C  CB  . LEU A 1 308 ? 192.468 226.530 302.758 1.00 22.36 ? 308 LEU A CB  1 
ATOM   1830 C  CG  . LEU A 1 308 ? 192.211 225.769 301.469 1.00 22.36 ? 308 LEU A CG  1 
ATOM   1831 C  CD1 . LEU A 1 308 ? 192.245 226.720 300.326 1.00 22.36 ? 308 LEU A CD1 1 
ATOM   1832 C  CD2 . LEU A 1 308 ? 193.252 224.699 301.292 1.00 22.36 ? 308 LEU A CD2 1 
ATOM   1833 N  N   . LEU A 1 309 ? 191.282 226.846 305.770 1.00 21.98 ? 309 LEU A N   1 
ATOM   1834 C  CA  . LEU A 1 309 ? 191.228 227.671 306.970 1.00 21.98 ? 309 LEU A CA  1 
ATOM   1835 C  C   . LEU A 1 309 ? 191.771 226.939 308.185 1.00 21.98 ? 309 LEU A C   1 
ATOM   1836 O  O   . LEU A 1 309 ? 192.454 227.538 309.018 1.00 21.98 ? 309 LEU A O   1 
ATOM   1837 C  CB  . LEU A 1 309 ? 189.801 228.140 307.218 1.00 21.98 ? 309 LEU A CB  1 
ATOM   1838 C  CG  . LEU A 1 309 ? 189.495 229.503 306.610 1.00 21.98 ? 309 LEU A CG  1 
ATOM   1839 C  CD1 . LEU A 1 309 ? 188.028 229.811 306.702 1.00 21.98 ? 309 LEU A CD1 1 
ATOM   1840 C  CD2 . LEU A 1 309 ? 190.294 230.562 307.295 1.00 21.98 ? 309 LEU A CD2 1 
ATOM   1841 N  N   . HIS A 1 310 ? 191.451 225.659 308.326 1.00 24.89 ? 310 HIS A N   1 
ATOM   1842 C  CA  . HIS A 1 310 ? 191.856 224.870 309.479 1.00 24.89 ? 310 HIS A CA  1 
ATOM   1843 C  C   . HIS A 1 310 ? 193.065 224.000 309.218 1.00 24.89 ? 310 HIS A C   1 
ATOM   1844 O  O   . HIS A 1 310 ? 193.907 223.842 310.098 1.00 24.89 ? 310 HIS A O   1 
ATOM   1845 C  CB  . HIS A 1 310 ? 190.705 223.985 309.925 1.00 24.89 ? 310 HIS A CB  1 
ATOM   1846 C  CG  . HIS A 1 310 ? 189.493 224.750 310.323 1.00 24.89 ? 310 HIS A CG  1 
ATOM   1847 N  ND1 . HIS A 1 310 ? 189.257 225.139 311.620 1.00 24.89 ? 310 HIS A ND1 1 
ATOM   1848 C  CD2 . HIS A 1 310 ? 188.441 225.189 309.598 1.00 24.89 ? 310 HIS A CD2 1 
ATOM   1849 C  CE1 . HIS A 1 310 ? 188.114 225.794 311.675 1.00 24.89 ? 310 HIS A CE1 1 
ATOM   1850 N  NE2 . HIS A 1 310 ? 187.599 225.838 310.462 1.00 24.89 ? 310 HIS A NE2 1 
ATOM   1851 N  N   . ASN A 1 311 ? 193.161 223.418 308.036 1.00 26.65 ? 311 ASN A N   1 
ATOM   1852 C  CA  . ASN A 1 311 ? 194.289 222.566 307.686 1.00 26.65 ? 311 ASN A CA  1 
ATOM   1853 C  C   . ASN A 1 311 ? 195.414 223.414 307.086 1.00 26.65 ? 311 ASN A C   1 
ATOM   1854 O  O   . ASN A 1 311 ? 195.879 223.200 305.980 1.00 26.65 ? 311 ASN A O   1 
ATOM   1855 C  CB  . ASN A 1 311 ? 193.813 221.465 306.746 1.00 26.65 ? 311 ASN A CB  1 
ATOM   1856 C  CG  . ASN A 1 311 ? 194.922 220.611 306.215 1.00 26.65 ? 311 ASN A CG  1 
ATOM   1857 O  OD1 . ASN A 1 311 ? 194.892 220.189 305.064 1.00 26.65 ? 311 ASN A OD1 1 
ATOM   1858 N  ND2 . ASN A 1 311 ? 195.904 220.330 307.053 1.00 26.65 ? 311 ASN A ND2 1 
ATOM   1859 N  N   . ALA A 1 312 ? 195.840 224.417 307.843 1.00 26.45 ? 312 ALA A N   1 
ATOM   1860 C  CA  . ALA A 1 312 ? 196.961 225.264 307.463 1.00 26.45 ? 312 ALA A CA  1 
ATOM   1861 C  C   . ALA A 1 312 ? 197.939 225.278 308.621 1.00 26.45 ? 312 ALA A C   1 
ATOM   1862 O  O   . ALA A 1 312 ? 197.527 225.310 309.780 1.00 26.45 ? 312 ALA A O   1 
ATOM   1863 C  CB  . ALA A 1 312 ? 196.519 226.679 307.126 1.00 26.45 ? 312 ALA A CB  1 
ATOM   1864 N  N   . ASP A 1 313 ? 199.227 225.323 308.311 1.00 30.29 ? 313 ASP A N   1 
ATOM   1865 C  CA  . ASP A 1 313 ? 200.235 225.229 309.351 1.00 30.29 ? 313 ASP A CA  1 
ATOM   1866 C  C   . ASP A 1 313 ? 200.097 226.356 310.355 1.00 30.29 ? 313 ASP A C   1 
ATOM   1867 O  O   . ASP A 1 313 ? 199.776 227.486 310.003 1.00 30.29 ? 313 ASP A O   1 
ATOM   1868 C  CB  . ASP A 1 313 ? 201.631 225.254 308.741 1.00 30.29 ? 313 ASP A CB  1 
ATOM   1869 C  CG  . ASP A 1 313 ? 202.689 224.671 309.670 1.00 30.29 ? 313 ASP A CG  1 
ATOM   1870 O  OD1 . ASP A 1 313 ? 202.487 224.656 310.900 1.00 30.29 ? 313 ASP A OD1 1 
ATOM   1871 O  OD2 . ASP A 1 313 ? 203.745 224.239 309.172 1.00 30.29 ? 313 ASP A OD2 1 
ATOM   1872 N  N   . PHE A 1 314 ? 200.316 226.031 311.623 1.00 29.62 ? 314 PHE A N   1 
ATOM   1873 C  CA  . PHE A 1 314 ? 200.199 227.030 312.670 1.00 29.62 ? 314 PHE A CA  1 
ATOM   1874 C  C   . PHE A 1 314 ? 201.224 228.137 312.504 1.00 29.62 ? 314 PHE A C   1 
ATOM   1875 O  O   . PHE A 1 314 ? 201.018 229.247 312.998 1.00 29.62 ? 314 PHE A O   1 
ATOM   1876 C  CB  . PHE A 1 314 ? 200.351 226.385 314.037 1.00 29.62 ? 314 PHE A CB  1 
ATOM   1877 C  CG  . PHE A 1 314 ? 199.220 225.490 314.415 1.00 29.62 ? 314 PHE A CG  1 
ATOM   1878 C  CD1 . PHE A 1 314 ? 197.926 225.817 314.091 1.00 29.62 ? 314 PHE A CD1 1 
ATOM   1879 C  CD2 . PHE A 1 314 ? 199.449 224.330 315.110 1.00 29.62 ? 314 PHE A CD2 1 
ATOM   1880 C  CE1 . PHE A 1 314 ? 196.885 225.003 314.446 1.00 29.62 ? 314 PHE A CE1 1 
ATOM   1881 C  CE2 . PHE A 1 314 ? 198.410 223.517 315.464 1.00 29.62 ? 314 PHE A CE2 1 
ATOM   1882 C  CZ  . PHE A 1 314 ? 197.126 223.856 315.131 1.00 29.62 ? 314 PHE A CZ  1 
ATOM   1883 N  N   . LYS A 1 315 ? 202.356 227.846 311.871 1.00 30.78 ? 315 LYS A N   1 
ATOM   1884 C  CA  . LYS A 1 315 ? 203.336 228.891 311.605 1.00 30.78 ? 315 LYS A CA  1 
ATOM   1885 C  C   . LYS A 1 315 ? 202.916 229.793 310.463 1.00 30.78 ? 315 LYS A C   1 
ATOM   1886 O  O   . LYS A 1 315 ? 203.354 230.943 310.400 1.00 30.78 ? 315 LYS A O   1 
ATOM   1887 C  CB  . LYS A 1 315 ? 204.710 228.299 311.304 1.00 30.78 ? 315 LYS A CB  1 
ATOM   1888 C  CG  . LYS A 1 315 ? 205.174 227.207 312.247 1.00 30.78 ? 315 LYS A CG  1 
ATOM   1889 C  CD  . LYS A 1 315 ? 204.771 227.494 313.688 1.00 30.78 ? 315 LYS A CD  1 
ATOM   1890 C  CE  . LYS A 1 315 ? 205.698 228.510 314.333 1.00 30.78 ? 315 LYS A CE  1 
ATOM   1891 N  NZ  . LYS A 1 315 ? 205.694 228.413 315.814 1.00 30.78 ? 315 LYS A NZ  1 
ATOM   1892 N  N   . GLN A 1 316 ? 202.093 229.296 309.549 1.00 26.33 ? 316 GLN A N   1 
ATOM   1893 C  CA  . GLN A 1 316 ? 201.645 230.086 308.415 1.00 26.33 ? 316 GLN A CA  1 
ATOM   1894 C  C   . GLN A 1 316 ? 200.520 231.043 308.762 1.00 26.33 ? 316 GLN A C   1 
ATOM   1895 O  O   . GLN A 1 316 ? 200.200 231.904 307.944 1.00 26.33 ? 316 GLN A O   1 
ATOM   1896 C  CB  . GLN A 1 316 ? 201.196 229.165 307.291 1.00 26.33 ? 316 GLN A CB  1 
ATOM   1897 C  CG  . GLN A 1 316 ? 202.322 228.531 306.501 1.00 26.33 ? 316 GLN A CG  1 
ATOM   1898 C  CD  . GLN A 1 316 ? 203.349 229.519 306.006 1.00 26.33 ? 316 GLN A CD  1 
ATOM   1899 O  OE1 . GLN A 1 316 ? 203.130 230.214 305.022 1.00 26.33 ? 316 GLN A OE1 1 
ATOM   1900 N  NE2 . GLN A 1 316 ? 204.486 229.570 306.673 1.00 26.33 ? 316 GLN A NE2 1 
ATOM   1901 N  N   . ARG A 1 317 ? 199.908 230.911 309.931 1.00 26.62 ? 317 ARG A N   1 
ATOM   1902 C  CA  . ARG A 1 317 ? 198.810 231.775 310.338 1.00 26.62 ? 317 ARG A CA  1 
ATOM   1903 C  C   . ARG A 1 317 ? 199.375 233.001 311.043 1.00 26.62 ? 317 ARG A C   1 
ATOM   1904 O  O   . ARG A 1 317 ? 200.019 232.878 312.086 1.00 26.62 ? 317 ARG A O   1 
ATOM   1905 C  CB  . ARG A 1 317 ? 197.847 231.018 311.242 1.00 26.62 ? 317 ARG A CB  1 
ATOM   1906 C  CG  . ARG A 1 317 ? 197.477 229.665 310.698 1.00 26.62 ? 317 ARG A CG  1 
ATOM   1907 C  CD  . ARG A 1 317 ? 196.087 229.265 311.099 1.00 26.62 ? 317 ARG A CD  1 
ATOM   1908 N  NE  . ARG A 1 317 ? 195.907 227.825 311.039 1.00 26.62 ? 317 ARG A NE  1 
ATOM   1909 C  CZ  . ARG A 1 317 ? 195.189 227.137 311.910 1.00 26.62 ? 317 ARG A CZ  1 
ATOM   1910 N  NH1 . ARG A 1 317 ? 194.569 227.733 312.909 1.00 26.62 ? 317 ARG A NH1 1 
ATOM   1911 N  NH2 . ARG A 1 317 ? 195.109 225.819 311.789 1.00 26.62 ? 317 ARG A NH2 1 
ATOM   1912 N  N   . ILE A 1 318 ? 199.107 234.178 310.489 1.00 27.19 ? 318 ILE A N   1 
ATOM   1913 C  CA  . ILE A 1 318 ? 199.661 235.432 310.974 1.00 27.19 ? 318 ILE A CA  1 
ATOM   1914 C  C   . ILE A 1 318 ? 198.546 236.276 311.566 1.00 27.19 ? 318 ILE A C   1 
ATOM   1915 O  O   . ILE A 1 318 ? 197.367 236.096 311.266 1.00 27.19 ? 318 ILE A O   1 
ATOM   1916 C  CB  . ILE A 1 318 ? 200.344 236.220 309.847 1.00 27.19 ? 318 ILE A CB  1 
ATOM   1917 C  CG1 . ILE A 1 318 ? 201.089 235.300 308.914 1.00 27.19 ? 318 ILE A CG1 1 
ATOM   1918 C  CG2 . ILE A 1 318 ? 201.358 237.162 310.412 1.00 27.19 ? 318 ILE A CG2 1 
ATOM   1919 C  CD1 . ILE A 1 318 ? 201.423 235.971 307.640 1.00 27.19 ? 318 ILE A CD1 1 
ATOM   1920 N  N   . GLN A 1 319 ? 198.932 237.221 312.410 1.00 32.82 ? 319 GLN A N   1 
ATOM   1921 C  CA  . GLN A 1 319 ? 198.010 238.186 312.980 1.00 32.82 ? 319 GLN A CA  1 
ATOM   1922 C  C   . GLN A 1 319 ? 198.318 239.570 312.431 1.00 32.82 ? 319 GLN A C   1 
ATOM   1923 O  O   . GLN A 1 319 ? 199.481 239.911 312.205 1.00 32.82 ? 319 GLN A O   1 
ATOM   1924 C  CB  . GLN A 1 319 ? 198.102 238.210 314.503 1.00 32.82 ? 319 GLN A CB  1 
ATOM   1925 C  CG  . GLN A 1 319 ? 198.322 236.865 315.116 1.00 32.82 ? 319 GLN A CG  1 
ATOM   1926 C  CD  . GLN A 1 319 ? 197.067 236.036 315.131 1.00 32.82 ? 319 GLN A CD  1 
ATOM   1927 O  OE1 . GLN A 1 319 ? 195.964 236.564 315.023 1.00 32.82 ? 319 GLN A OE1 1 
ATOM   1928 N  NE2 . GLN A 1 319 ? 197.223 234.727 315.268 1.00 32.82 ? 319 GLN A NE2 1 
ATOM   1929 N  N   . THR A 1 320 ? 197.273 240.355 312.196 1.00 34.41 ? 320 THR A N   1 
ATOM   1930 C  CA  . THR A 1 320 ? 197.442 241.702 311.677 1.00 34.41 ? 320 THR A CA  1 
ATOM   1931 C  C   . THR A 1 320 ? 198.173 242.576 312.689 1.00 34.41 ? 320 THR A C   1 
ATOM   1932 O  O   . THR A 1 320 ? 198.017 242.423 313.901 1.00 34.41 ? 320 THR A O   1 
ATOM   1933 C  CB  . THR A 1 320 ? 196.093 242.321 311.339 1.00 34.41 ? 320 THR A CB  1 
ATOM   1934 O  OG1 . THR A 1 320 ? 195.232 242.207 312.474 1.00 34.41 ? 320 THR A OG1 1 
ATOM   1935 C  CG2 . THR A 1 320 ? 195.474 241.617 310.173 1.00 34.41 ? 320 THR A CG2 1 
ATOM   1936 N  N   . HIS A 1 321 ? 198.998 243.488 312.177 1.00 40.93 ? 321 HIS A N   1 
ATOM   1937 C  CA  . HIS A 1 321 ? 199.749 244.378 313.054 1.00 40.93 ? 321 HIS A CA  1 
ATOM   1938 C  C   . HIS A 1 321 ? 198.839 245.355 313.786 1.00 40.93 ? 321 HIS A C   1 
ATOM   1939 O  O   . HIS A 1 321 ? 199.061 245.651 314.964 1.00 40.93 ? 321 HIS A O   1 
ATOM   1940 C  CB  . HIS A 1 321 ? 200.806 245.129 312.248 1.00 40.93 ? 321 HIS A CB  1 
ATOM   1941 C  CG  . HIS A 1 321 ? 201.923 245.674 313.081 1.00 40.93 ? 321 HIS A CG  1 
ATOM   1942 N  ND1 . HIS A 1 321 ? 203.016 244.920 313.446 1.00 40.93 ? 321 HIS A ND1 1 
ATOM   1943 C  CD2 . HIS A 1 321 ? 202.129 246.909 313.595 1.00 40.93 ? 321 HIS A CD2 1 
ATOM   1944 C  CE1 . HIS A 1 321 ? 203.837 245.660 314.168 1.00 40.93 ? 321 HIS A CE1 1 
ATOM   1945 N  NE2 . HIS A 1 321 ? 203.323 246.872 314.272 1.00 40.93 ? 321 HIS A NE2 1 
ATOM   1946 N  N   . SER A 1 322 ? 197.820 245.872 313.110 1.00 40.02 ? 322 SER A N   1 
ATOM   1947 C  CA  . SER A 1 322 ? 196.915 246.852 313.694 1.00 40.02 ? 322 SER A CA  1 
ATOM   1948 C  C   . SER A 1 322 ? 195.478 246.373 313.813 1.00 40.02 ? 322 SER A C   1 
ATOM   1949 O  O   . SER A 1 322 ? 194.779 246.794 314.733 1.00 40.02 ? 322 SER A O   1 
ATOM   1950 C  CB  . SER A 1 322 ? 196.932 248.142 312.868 1.00 40.02 ? 322 SER A CB  1 
ATOM   1951 O  OG  . SER A 1 322 ? 196.735 247.855 311.496 1.00 40.02 ? 322 SER A OG  1 
ATOM   1952 N  N   . GLY A 1 323 ? 195.024 245.505 312.919 1.00 36.11 ? 323 GLY A N   1 
ATOM   1953 C  CA  . GLY A 1 323 ? 193.674 245.002 312.934 1.00 36.11 ? 323 GLY A CA  1 
ATOM   1954 C  C   . GLY A 1 323 ? 192.916 245.179 311.633 1.00 36.11 ? 323 GLY A C   1 
ATOM   1955 O  O   . GLY A 1 323 ? 192.230 244.258 311.189 1.00 36.11 ? 323 GLY A O   1 
ATOM   1956 N  N   . PRO A 1 324 ? 193.006 246.340 310.992 1.00 31.94 ? 324 PRO A N   1 
ATOM   1957 C  CA  . PRO A 1 324 ? 192.506 246.459 309.626 1.00 31.94 ? 324 PRO A CA  1 
ATOM   1958 C  C   . PRO A 1 324 ? 193.499 245.872 308.643 1.00 31.94 ? 324 PRO A C   1 
ATOM   1959 O  O   . PRO A 1 324 ? 194.699 245.794 308.937 1.00 31.94 ? 324 PRO A O   1 
ATOM   1960 C  CB  . PRO A 1 324 ? 192.339 247.970 309.440 1.00 31.94 ? 324 PRO A CB  1 
ATOM   1961 C  CG  . PRO A 1 324 ? 193.232 248.567 310.409 1.00 31.94 ? 324 PRO A CG  1 
ATOM   1962 C  CD  . PRO A 1 324 ? 193.226 247.663 311.591 1.00 31.94 ? 324 PRO A CD  1 
ATOM   1963 N  N   . PRO A 1 325 ? 193.047 245.433 307.483 1.00 27.76 ? 325 PRO A N   1 
ATOM   1964 C  CA  . PRO A 1 325 ? 193.954 244.805 306.504 1.00 27.76 ? 325 PRO A CA  1 
ATOM   1965 C  C   . PRO A 1 325 ? 194.780 245.810 305.709 1.00 27.76 ? 325 PRO A C   1 
ATOM   1966 O  O   . PRO A 1 325 ? 194.626 245.997 304.505 1.00 27.76 ? 325 PRO A O   1 
ATOM   1967 C  CB  . PRO A 1 325 ? 192.982 244.016 305.627 1.00 27.76 ? 325 PRO A CB  1 
ATOM   1968 C  CG  . PRO A 1 325 ? 191.741 244.777 305.684 1.00 27.76 ? 325 PRO A CG  1 
ATOM   1969 C  CD  . PRO A 1 325 ? 191.653 245.410 307.031 1.00 27.76 ? 325 PRO A CD  1 
ATOM   1970 N  N   . THR A 1 326 ? 195.744 246.424 306.383 1.00 26.44 ? 326 THR A N   1 
ATOM   1971 C  CA  . THR A 1 326 ? 196.627 247.389 305.762 1.00 26.44 ? 326 THR A CA  1 
ATOM   1972 C  C   . THR A 1 326 ? 197.528 246.694 304.752 1.00 26.44 ? 326 THR A C   1 
ATOM   1973 O  O   . THR A 1 326 ? 197.752 245.490 304.841 1.00 26.44 ? 326 THR A O   1 
ATOM   1974 C  CB  . THR A 1 326 ? 197.463 248.096 306.816 1.00 26.44 ? 326 THR A CB  1 
ATOM   1975 O  OG1 . THR A 1 326 ? 198.470 247.206 307.295 1.00 26.44 ? 326 THR A OG1 1 
ATOM   1976 C  CG2 . THR A 1 326 ? 196.586 248.502 307.975 1.00 26.44 ? 326 THR A CG2 1 
ATOM   1977 N  N   . PRO A 1 327 ? 198.028 247.430 303.756 1.00 25.06 ? 327 PRO A N   1 
ATOM   1978 C  CA  . PRO A 1 327 ? 198.909 246.815 302.752 1.00 25.06 ? 327 PRO A CA  1 
ATOM   1979 C  C   . PRO A 1 327 ? 200.180 246.222 303.321 1.00 25.06 ? 327 PRO A C   1 
ATOM   1980 O  O   . PRO A 1 327 ? 200.775 245.355 302.677 1.00 25.06 ? 327 PRO A O   1 
ATOM   1981 C  CB  . PRO A 1 327 ? 199.192 247.968 301.783 1.00 25.06 ? 327 PRO A CB  1 
ATOM   1982 C  CG  . PRO A 1 327 ? 198.767 249.199 302.482 1.00 25.06 ? 327 PRO A CG  1 
ATOM   1983 C  CD  . PRO A 1 327 ? 197.678 248.809 303.391 1.00 25.06 ? 327 PRO A CD  1 
ATOM   1984 N  N   . ASP A 1 328 ? 200.642 246.678 304.481 1.00 25.61 ? 328 ASP A N   1 
ATOM   1985 C  CA  . ASP A 1 328 ? 201.787 246.040 305.118 1.00 25.61 ? 328 ASP A CA  1 
ATOM   1986 C  C   . ASP A 1 328 ? 201.469 244.598 305.489 1.00 25.61 ? 328 ASP A C   1 
ATOM   1987 O  O   . ASP A 1 328 ? 202.335 243.723 305.407 1.00 25.61 ? 328 ASP A O   1 
ATOM   1988 C  CB  . ASP A 1 328 ? 202.190 246.829 306.355 1.00 25.61 ? 328 ASP A CB  1 
ATOM   1989 C  CG  . ASP A 1 328 ? 202.583 248.240 306.029 1.00 25.61 ? 328 ASP A CG  1 
ATOM   1990 O  OD1 . ASP A 1 328 ? 202.245 248.702 304.926 1.00 25.61 ? 328 ASP A OD1 1 
ATOM   1991 O  OD2 . ASP A 1 328 ? 203.219 248.896 306.871 1.00 25.61 ? 328 ASP A OD2 1 
ATOM   1992 N  N   . ASP A 1 329 ? 200.235 244.335 305.918 1.00 26.04 ? 329 ASP A N   1 
ATOM   1993 C  CA  . ASP A 1 329 ? 199.817 242.970 306.219 1.00 26.04 ? 329 ASP A CA  1 
ATOM   1994 C  C   . ASP A 1 329 ? 199.823 242.105 304.970 1.00 26.04 ? 329 ASP A C   1 
ATOM   1995 O  O   . ASP A 1 329 ? 200.200 240.934 305.022 1.00 26.04 ? 329 ASP A O   1 
ATOM   1996 C  CB  . ASP A 1 329 ? 198.439 242.976 306.857 1.00 26.04 ? 329 ASP A CB  1 
ATOM   1997 C  CG  . ASP A 1 329 ? 198.402 243.786 308.114 1.00 26.04 ? 329 ASP A CG  1 
ATOM   1998 O  OD1 . ASP A 1 329 ? 199.480 244.062 308.656 1.00 26.04 ? 329 ASP A OD1 1 
ATOM   1999 O  OD2 . ASP A 1 329 ? 197.302 244.150 308.564 1.00 26.04 ? 329 ASP A OD2 1 
ATOM   2000 N  N   . LEU A 1 330 ? 199.399 242.658 303.839 1.00 23.45 ? 330 LEU A N   1 
ATOM   2001 C  CA  . LEU A 1 330 ? 199.456 241.915 302.586 1.00 23.45 ? 330 LEU A CA  1 
ATOM   2002 C  C   . LEU A 1 330 ? 200.898 241.637 302.182 1.00 23.45 ? 330 LEU A C   1 
ATOM   2003 O  O   . LEU A 1 330 ? 201.208 240.559 301.669 1.00 23.45 ? 330 LEU A O   1 
ATOM   2004 C  CB  . LEU A 1 330 ? 198.719 242.677 301.495 1.00 23.45 ? 330 LEU A CB  1 
ATOM   2005 C  CG  . LEU A 1 330 ? 197.233 242.887 301.760 1.00 23.45 ? 330 LEU A CG  1 
ATOM   2006 C  CD1 . LEU A 1 330 ? 196.635 243.781 300.707 1.00 23.45 ? 330 LEU A CD1 1 
ATOM   2007 C  CD2 . LEU A 1 330 ? 196.533 241.551 301.776 1.00 23.45 ? 330 LEU A CD2 1 
ATOM   2008 N  N   . ASP A 1 331 ? 201.791 242.602 302.388 1.00 24.26 ? 331 ASP A N   1 
ATOM   2009 C  CA  . ASP A 1 331 ? 203.205 242.372 302.110 1.00 24.26 ? 331 ASP A CA  1 
ATOM   2010 C  C   . ASP A 1 331 ? 203.769 241.260 302.983 1.00 24.26 ? 331 ASP A C   1 
ATOM   2011 O  O   . ASP A 1 331 ? 204.531 240.413 302.508 1.00 24.26 ? 331 ASP A O   1 
ATOM   2012 C  CB  . ASP A 1 331 ? 203.993 243.658 302.325 1.00 24.26 ? 331 ASP A CB  1 
ATOM   2013 C  CG  . ASP A 1 331 ? 203.811 244.635 301.205 1.00 24.26 ? 331 ASP A CG  1 
ATOM   2014 O  OD1 . ASP A 1 331 ? 204.171 244.300 300.064 1.00 24.26 ? 331 ASP A OD1 1 
ATOM   2015 O  OD2 . ASP A 1 331 ? 203.295 245.735 301.456 1.00 24.26 ? 331 ASP A OD2 1 
ATOM   2016 N  N   . GLU A 1 332 ? 203.422 241.259 304.268 1.00 24.45 ? 332 GLU A N   1 
ATOM   2017 C  CA  . GLU A 1 332 ? 203.865 240.194 305.163 1.00 24.45 ? 332 GLU A CA  1 
ATOM   2018 C  C   . GLU A 1 332 ? 203.300 238.845 304.746 1.00 24.45 ? 332 GLU A C   1 
ATOM   2019 O  O   . GLU A 1 332 ? 203.988 237.825 304.823 1.00 24.45 ? 332 GLU A O   1 
ATOM   2020 C  CB  . GLU A 1 332 ? 203.463 240.515 306.592 1.00 24.45 ? 332 GLU A CB  1 
ATOM   2021 C  CG  . GLU A 1 332 ? 203.944 239.514 307.589 1.00 24.45 ? 332 GLU A CG  1 
ATOM   2022 C  CD  . GLU A 1 332 ? 205.360 239.763 308.027 1.00 24.45 ? 332 GLU A CD  1 
ATOM   2023 O  OE1 . GLU A 1 332 ? 206.006 240.685 307.494 1.00 24.45 ? 332 GLU A OE1 1 
ATOM   2024 O  OE2 . GLU A 1 332 ? 205.824 239.044 308.930 1.00 24.45 ? 332 GLU A OE2 1 
ATOM   2025 N  N   . LEU A 1 333 ? 202.040 238.817 304.325 1.00 22.38 ? 333 LEU A N   1 
ATOM   2026 C  CA  . LEU A 1 333 ? 201.422 237.575 303.878 1.00 22.38 ? 333 LEU A CA  1 
ATOM   2027 C  C   . LEU A 1 333 ? 202.112 237.037 302.635 1.00 22.38 ? 333 LEU A C   1 
ATOM   2028 O  O   . LEU A 1 333 ? 202.229 235.822 302.460 1.00 22.38 ? 333 LEU A O   1 
ATOM   2029 C  CB  . LEU A 1 333 ? 199.935 237.801 303.626 1.00 22.38 ? 333 LEU A CB  1 
ATOM   2030 C  CG  . LEU A 1 333 ? 199.008 236.588 303.606 1.00 22.38 ? 333 LEU A CG  1 
ATOM   2031 C  CD1 . LEU A 1 333 ? 199.283 235.691 304.770 1.00 22.38 ? 333 LEU A CD1 1 
ATOM   2032 C  CD2 . LEU A 1 333 ? 197.577 237.041 303.626 1.00 22.38 ? 333 LEU A CD2 1 
ATOM   2033 N  N   . LEU A 1 334 ? 202.536 237.921 301.740 1.00 22.86 ? 334 LEU A N   1 
ATOM   2034 C  CA  . LEU A 1 334 ? 203.318 237.491 300.585 1.00 22.86 ? 334 LEU A CA  1 
ATOM   2035 C  C   . LEU A 1 334 ? 204.754 237.137 300.952 1.00 22.86 ? 334 LEU A C   1 
ATOM   2036 O  O   . LEU A 1 334 ? 205.424 236.454 300.176 1.00 22.86 ? 334 LEU A O   1 
ATOM   2037 C  CB  . LEU A 1 334 ? 203.325 238.565 299.505 1.00 22.86 ? 334 LEU A CB  1 
ATOM   2038 C  CG  . LEU A 1 334 ? 202.058 238.783 298.696 1.00 22.86 ? 334 LEU A CG  1 
ATOM   2039 C  CD1 . LEU A 1 334 ? 202.006 240.211 298.256 1.00 22.86 ? 334 LEU A CD1 1 
ATOM   2040 C  CD2 . LEU A 1 334 ? 202.048 237.873 297.512 1.00 22.86 ? 334 LEU A CD2 1 
ATOM   2041 N  N   . CYS A 1 335 ? 205.252 237.609 302.095 1.00 23.00 ? 335 CYS A N   1 
ATOM   2042 C  CA  . CYS A 1 335 ? 206.631 237.326 302.483 1.00 23.00 ? 335 CYS A CA  1 
ATOM   2043 C  C   . CYS A 1 335 ? 206.841 235.874 302.863 1.00 23.00 ? 335 CYS A C   1 
ATOM   2044 O  O   . CYS A 1 335 ? 207.911 235.318 302.599 1.00 23.00 ? 335 CYS A O   1 
ATOM   2045 C  CB  . CYS A 1 335 ? 207.013 238.193 303.682 1.00 23.00 ? 335 CYS A CB  1 
ATOM   2046 S  SG  . CYS A 1 335 ? 208.472 237.665 304.594 1.00 23.00 ? 335 CYS A SG  1 
ATOM   2047 N  N   . ARG A 1 336 ? 205.842 235.250 303.480 1.00 23.19 ? 336 ARG A N   1 
ATOM   2048 C  CA  . ARG A 1 336 ? 206.046 233.971 304.137 1.00 23.19 ? 336 ARG A CA  1 
ATOM   2049 C  C   . ARG A 1 336 ? 206.175 232.801 303.178 1.00 23.19 ? 336 ARG A C   1 
ATOM   2050 O  O   . ARG A 1 336 ? 206.629 231.735 303.595 1.00 23.19 ? 336 ARG A O   1 
ATOM   2051 C  CB  . ARG A 1 336 ? 204.914 233.724 305.116 1.00 23.19 ? 336 ARG A CB  1 
ATOM   2052 C  CG  . ARG A 1 336 ? 204.676 234.862 306.069 1.00 23.19 ? 336 ARG A CG  1 
ATOM   2053 C  CD  . ARG A 1 336 ? 205.831 235.006 307.008 1.00 23.19 ? 336 ARG A CD  1 
ATOM   2054 N  NE  . ARG A 1 336 ? 205.557 235.950 308.081 1.00 23.19 ? 336 ARG A NE  1 
ATOM   2055 C  CZ  . ARG A 1 336 ? 205.072 235.616 309.268 1.00 23.19 ? 336 ARG A CZ  1 
ATOM   2056 N  NH1 . ARG A 1 336 ? 204.784 234.362 309.567 1.00 23.19 ? 336 ARG A NH1 1 
ATOM   2057 N  NH2 . ARG A 1 336 ? 204.882 236.562 310.180 1.00 23.19 ? 336 ARG A NH2 1 
ATOM   2058 N  N   . ARG A 1 337 ? 205.797 232.954 301.917 1.00 22.63 ? 337 ARG A N   1 
ATOM   2059 C  CA  . ARG A 1 337 ? 205.877 231.835 300.996 1.00 22.63 ? 337 ARG A CA  1 
ATOM   2060 C  C   . ARG A 1 337 ? 206.252 232.315 299.610 1.00 22.63 ? 337 ARG A C   1 
ATOM   2061 O  O   . ARG A 1 337 ? 205.991 233.454 299.228 1.00 22.63 ? 337 ARG A O   1 
ATOM   2062 C  CB  . ARG A 1 337 ? 204.565 231.048 300.943 1.00 22.63 ? 337 ARG A CB  1 
ATOM   2063 C  CG  . ARG A 1 337 ? 203.570 231.520 299.909 1.00 22.63 ? 337 ARG A CG  1 
ATOM   2064 C  CD  . ARG A 1 337 ? 202.194 231.151 300.345 1.00 22.63 ? 337 ARG A CD  1 
ATOM   2065 N  NE  . ARG A 1 337 ? 202.007 231.483 301.748 1.00 22.63 ? 337 ARG A NE  1 
ATOM   2066 C  CZ  . ARG A 1 337 ? 201.902 232.711 302.226 1.00 22.63 ? 337 ARG A CZ  1 
ATOM   2067 N  NH1 . ARG A 1 337 ? 201.915 233.765 301.430 1.00 22.63 ? 337 ARG A NH1 1 
ATOM   2068 N  NH2 . ARG A 1 337 ? 201.796 232.886 303.537 1.00 22.63 ? 337 ARG A NH2 1 
ATOM   2069 N  N   . ARG A 1 338 ? 206.833 231.405 298.845 1.00 27.07 ? 338 ARG A N   1 
ATOM   2070 C  CA  . ARG A 1 338 ? 207.324 231.720 297.519 1.00 27.07 ? 338 ARG A CA  1 
ATOM   2071 C  C   . ARG A 1 338 ? 206.274 231.398 296.472 1.00 27.07 ? 338 ARG A C   1 
ATOM   2072 O  O   . ARG A 1 338 ? 205.615 230.362 296.531 1.00 27.07 ? 338 ARG A O   1 
ATOM   2073 C  CB  . ARG A 1 338 ? 208.601 230.936 297.229 1.00 27.07 ? 338 ARG A CB  1 
ATOM   2074 C  CG  . ARG A 1 338 ? 208.737 230.480 295.793 1.00 27.07 ? 338 ARG A CG  1 
ATOM   2075 C  CD  . ARG A 1 338 ? 209.869 229.491 295.633 1.00 27.07 ? 338 ARG A CD  1 
ATOM   2076 N  NE  . ARG A 1 338 ? 209.660 228.294 296.437 1.00 27.07 ? 338 ARG A NE  1 
ATOM   2077 C  CZ  . ARG A 1 338 ? 208.877 227.285 296.084 1.00 27.07 ? 338 ARG A CZ  1 
ATOM   2078 N  NH1 . ARG A 1 338 ? 208.214 227.294 294.940 1.00 27.07 ? 338 ARG A NH1 1 
ATOM   2079 N  NH2 . ARG A 1 338 ? 208.750 226.246 296.902 1.00 27.07 ? 338 ARG A NH2 1 
ATOM   2080 N  N   . GLY A 1 339 ? 206.126 232.296 295.511 1.00 25.60 ? 339 GLY A N   1 
ATOM   2081 C  CA  . GLY A 1 339 ? 205.227 232.070 294.400 1.00 25.60 ? 339 GLY A CA  1 
ATOM   2082 C  C   . GLY A 1 339 ? 203.764 231.992 294.760 1.00 25.60 ? 339 GLY A C   1 
ATOM   2083 O  O   . GLY A 1 339 ? 203.061 231.115 294.253 1.00 25.60 ? 339 GLY A O   1 
ATOM   2084 N  N   . THR A 1 340 ? 203.282 232.899 295.604 1.00 23.88 ? 340 THR A N   1 
ATOM   2085 C  CA  . THR A 1 340 ? 201.868 232.933 295.937 1.00 23.88 ? 340 THR A CA  1 
ATOM   2086 C  C   . THR A 1 340 ? 201.033 233.130 294.686 1.00 23.88 ? 340 THR A C   1 
ATOM   2087 O  O   . THR A 1 340 ? 201.358 233.953 293.832 1.00 23.88 ? 340 THR A O   1 
ATOM   2088 C  CB  . THR A 1 340 ? 201.593 234.058 296.924 1.00 23.88 ? 340 THR A CB  1 
ATOM   2089 O  OG1 . THR A 1 340 ? 202.381 233.861 298.096 1.00 23.88 ? 340 THR A OG1 1 
ATOM   2090 C  CG2 . THR A 1 340 ? 200.152 234.098 297.306 1.00 23.88 ? 340 THR A CG2 1 
ATOM   2091 N  N   . LYS A 1 341 ? 199.975 232.343 294.560 1.00 24.13 ? 341 LYS A N   1 
ATOM   2092 C  CA  . LYS A 1 341 ? 199.133 232.388 293.378 1.00 24.13 ? 341 LYS A CA  1 
ATOM   2093 C  C   . LYS A 1 341 ? 198.037 233.429 293.518 1.00 24.13 ? 341 LYS A C   1 
ATOM   2094 O  O   . LYS A 1 341 ? 197.872 234.273 292.636 1.00 24.13 ? 341 LYS A O   1 
ATOM   2095 C  CB  . LYS A 1 341 ? 198.534 231.017 293.096 1.00 24.13 ? 341 LYS A CB  1 
ATOM   2096 C  CG  . LYS A 1 341 ? 199.338 230.205 292.116 1.00 24.13 ? 341 LYS A CG  1 
ATOM   2097 C  CD  . LYS A 1 341 ? 199.051 230.621 290.701 1.00 24.13 ? 341 LYS A CD  1 
ATOM   2098 C  CE  . LYS A 1 341 ? 197.638 230.230 290.302 1.00 24.13 ? 341 LYS A CE  1 
ATOM   2099 N  NZ  . LYS A 1 341 ? 197.424 230.332 288.836 1.00 24.13 ? 341 LYS A NZ  1 
ATOM   2100 N  N   . PHE A 1 342 ? 197.266 233.377 294.601 1.00 23.05 ? 342 PHE A N   1 
ATOM   2101 C  CA  . PHE A 1 342 ? 196.188 234.345 294.736 1.00 23.05 ? 342 PHE A CA  1 
ATOM   2102 C  C   . PHE A 1 342 ? 195.777 234.476 296.192 1.00 23.05 ? 342 PHE A C   1 
ATOM   2103 O  O   . PHE A 1 342 ? 196.166 233.682 297.053 1.00 23.05 ? 342 PHE A O   1 
ATOM   2104 C  CB  . PHE A 1 342 ? 194.990 233.966 293.860 1.00 23.05 ? 342 PHE A CB  1 
ATOM   2105 C  CG  . PHE A 1 342 ? 194.465 232.590 294.110 1.00 23.05 ? 342 PHE A CG  1 
ATOM   2106 C  CD1 . PHE A 1 342 ? 193.504 232.369 295.074 1.00 23.05 ? 342 PHE A CD1 1 
ATOM   2107 C  CD2 . PHE A 1 342 ? 194.937 231.516 293.394 1.00 23.05 ? 342 PHE A CD2 1 
ATOM   2108 C  CE1 . PHE A 1 342 ? 193.027 231.113 295.311 1.00 23.05 ? 342 PHE A CE1 1 
ATOM   2109 C  CE2 . PHE A 1 342 ? 194.465 230.258 293.636 1.00 23.05 ? 342 PHE A CE2 1 
ATOM   2110 C  CZ  . PHE A 1 342 ? 193.509 230.057 294.592 1.00 23.05 ? 342 PHE A CZ  1 
ATOM   2111 N  N   . PHE A 1 343 ? 195.000 235.523 296.452 1.00 22.56 ? 343 PHE A N   1 
ATOM   2112 C  CA  . PHE A 1 343 ? 194.375 235.776 297.740 1.00 22.56 ? 343 PHE A CA  1 
ATOM   2113 C  C   . PHE A 1 343 ? 192.894 235.441 297.666 1.00 22.56 ? 343 PHE A C   1 
ATOM   2114 O  O   . PHE A 1 343 ? 192.244 235.684 296.651 1.00 22.56 ? 343 PHE A O   1 
ATOM   2115 C  CB  . PHE A 1 343 ? 194.513 237.236 298.153 1.00 22.56 ? 343 PHE A CB  1 
ATOM   2116 C  CG  . PHE A 1 343 ? 195.901 237.653 298.494 1.00 22.56 ? 343 PHE A CG  1 
ATOM   2117 C  CD1 . PHE A 1 343 ? 196.398 237.468 299.756 1.00 22.56 ? 343 PHE A CD1 1 
ATOM   2118 C  CD2 . PHE A 1 343 ? 196.688 238.294 297.567 1.00 22.56 ? 343 PHE A CD2 1 
ATOM   2119 C  CE1 . PHE A 1 343 ? 197.667 237.873 300.067 1.00 22.56 ? 343 PHE A CE1 1 
ATOM   2120 C  CE2 . PHE A 1 343 ? 197.947 238.698 297.881 1.00 22.56 ? 343 PHE A CE2 1 
ATOM   2121 C  CZ  . PHE A 1 343 ? 198.434 238.487 299.128 1.00 22.56 ? 343 PHE A CZ  1 
ATOM   2122 N  N   . LEU A 1 344 ? 192.367 234.899 298.753 1.00 23.25 ? 344 LEU A N   1 
ATOM   2123 C  CA  . LEU A 1 344 ? 190.948 234.645 298.940 1.00 23.25 ? 344 LEU A CA  1 
ATOM   2124 C  C   . LEU A 1 344 ? 190.473 235.414 300.157 1.00 23.25 ? 344 LEU A C   1 
ATOM   2125 O  O   . LEU A 1 344 ? 191.050 235.286 301.238 1.00 23.25 ? 344 LEU A O   1 
ATOM   2126 C  CB  . LEU A 1 344 ? 190.661 233.162 299.124 1.00 23.25 ? 344 LEU A CB  1 
ATOM   2127 C  CG  . LEU A 1 344 ? 190.247 232.325 297.924 1.00 23.25 ? 344 LEU A CG  1 
ATOM   2128 C  CD1 . LEU A 1 344 ? 189.923 230.957 298.412 1.00 23.25 ? 344 LEU A CD1 1 
ATOM   2129 C  CD2 . LEU A 1 344 ? 189.055 232.914 297.228 1.00 23.25 ? 344 LEU A CD2 1 
ATOM   2130 N  N   . ALA A 1 345 ? 189.432 236.213 299.984 1.00 23.24 ? 345 ALA A N   1 
ATOM   2131 C  CA  . ALA A 1 345 ? 188.908 236.996 301.083 1.00 23.24 ? 345 ALA A CA  1 
ATOM   2132 C  C   . ALA A 1 345 ? 187.438 237.266 300.833 1.00 23.24 ? 345 ALA A C   1 
ATOM   2133 O  O   . ALA A 1 345 ? 186.956 237.181 299.707 1.00 23.24 ? 345 ALA A O   1 
ATOM   2134 C  CB  . ALA A 1 345 ? 189.675 238.304 301.243 1.00 23.24 ? 345 ALA A CB  1 
ATOM   2135 N  N   . HIS A 1 346 ? 186.729 237.573 301.903 1.00 24.48 ? 346 HIS A N   1 
ATOM   2136 C  CA  . HIS A 1 346 ? 185.338 237.952 301.790 1.00 24.48 ? 346 HIS A CA  1 
ATOM   2137 C  C   . HIS A 1 346 ? 185.214 239.293 301.071 1.00 24.48 ? 346 HIS A C   1 
ATOM   2138 O  O   . HIS A 1 346 ? 186.110 240.131 301.157 1.00 24.48 ? 346 HIS A O   1 
ATOM   2139 C  CB  . HIS A 1 346 ? 184.725 238.054 303.178 1.00 24.48 ? 346 HIS A CB  1 
ATOM   2140 C  CG  . HIS A 1 346 ? 183.256 237.814 303.210 1.00 24.48 ? 346 HIS A CG  1 
ATOM   2141 N  ND1 . HIS A 1 346 ? 182.344 238.838 303.324 1.00 24.48 ? 346 HIS A ND1 1 
ATOM   2142 C  CD2 . HIS A 1 346 ? 182.535 236.675 303.132 1.00 24.48 ? 346 HIS A CD2 1 
ATOM   2143 C  CE1 . HIS A 1 346 ? 181.124 238.340 303.318 1.00 24.48 ? 346 HIS A CE1 1 
ATOM   2144 N  NE2 . HIS A 1 346 ? 181.212 237.029 303.205 1.00 24.48 ? 346 HIS A NE2 1 
ATOM   2145 N  N   . PRO A 1 347 ? 184.117 239.518 300.345 1.00 23.50 ? 347 PRO A N   1 
ATOM   2146 C  CA  . PRO A 1 347 ? 183.926 240.828 299.711 1.00 23.50 ? 347 PRO A CA  1 
ATOM   2147 C  C   . PRO A 1 347 ? 183.954 241.984 300.691 1.00 23.50 ? 347 PRO A C   1 
ATOM   2148 O  O   . PRO A 1 347 ? 184.402 243.078 300.336 1.00 23.50 ? 347 PRO A O   1 
ATOM   2149 C  CB  . PRO A 1 347 ? 182.565 240.678 299.032 1.00 23.50 ? 347 PRO A CB  1 
ATOM   2150 C  CG  . PRO A 1 347 ? 182.462 239.244 298.755 1.00 23.50 ? 347 PRO A CG  1 
ATOM   2151 C  CD  . PRO A 1 347 ? 183.101 238.558 299.898 1.00 23.50 ? 347 PRO A CD  1 
ATOM   2152 N  N   . ARG A 1 348 ? 183.477 241.781 301.913 1.00 25.74 ? 348 ARG A N   1 
ATOM   2153 C  CA  . ARG A 1 348 ? 183.624 242.800 302.940 1.00 25.74 ? 348 ARG A CA  1 
ATOM   2154 C  C   . ARG A 1 348 ? 185.090 243.049 303.260 1.00 25.74 ? 348 ARG A C   1 
ATOM   2155 O  O   . ARG A 1 348 ? 185.506 244.195 303.468 1.00 25.74 ? 348 ARG A O   1 
ATOM   2156 C  CB  . ARG A 1 348 ? 182.871 242.366 304.186 1.00 25.74 ? 348 ARG A CB  1 
ATOM   2157 C  CG  . ARG A 1 348 ? 182.091 243.453 304.819 1.00 25.74 ? 348 ARG A CG  1 
ATOM   2158 C  CD  . ARG A 1 348 ? 181.053 242.914 305.746 1.00 25.74 ? 348 ARG A CD  1 
ATOM   2159 N  NE  . ARG A 1 348 ? 180.768 243.879 306.794 1.00 25.74 ? 348 ARG A NE  1 
ATOM   2160 C  CZ  . ARG A 1 348 ? 180.062 243.610 307.878 1.00 25.74 ? 348 ARG A CZ  1 
ATOM   2161 N  NH1 . ARG A 1 348 ? 179.553 242.409 308.087 1.00 25.74 ? 348 ARG A NH1 1 
ATOM   2162 N  NH2 . ARG A 1 348 ? 179.857 244.571 308.772 1.00 25.74 ? 348 ARG A NH2 1 
ATOM   2163 N  N   . THR A 1 349 ? 185.888 241.983 303.326 1.00 24.45 ? 349 THR A N   1 
ATOM   2164 C  CA  . THR A 1 349 ? 187.319 242.137 303.563 1.00 24.45 ? 349 THR A CA  1 
ATOM   2165 C  C   . THR A 1 349 ? 187.991 242.874 302.416 1.00 24.45 ? 349 THR A C   1 
ATOM   2166 O  O   . THR A 1 349 ? 188.875 243.703 302.637 1.00 24.45 ? 349 THR A O   1 
ATOM   2167 C  CB  . THR A 1 349 ? 187.969 240.776 303.783 1.00 24.45 ? 349 THR A CB  1 
ATOM   2168 O  OG1 . THR A 1 349 ? 187.456 240.203 304.984 1.00 24.45 ? 349 THR A OG1 1 
ATOM   2169 C  CG2 . THR A 1 349 ? 189.452 240.913 303.928 1.00 24.45 ? 349 THR A CG2 1 
ATOM   2170 N  N   . ILE A 1 350 ? 187.583 242.590 301.182 1.00 22.88 ? 350 ILE A N   1 
ATOM   2171 C  CA  . ILE A 1 350 ? 188.145 243.291 300.037 1.00 22.88 ? 350 ILE A CA  1 
ATOM   2172 C  C   . ILE A 1 350 ? 187.771 244.763 300.071 1.00 22.88 ? 350 ILE A C   1 
ATOM   2173 O  O   . ILE A 1 350 ? 188.569 245.626 299.696 1.00 22.88 ? 350 ILE A O   1 
ATOM   2174 C  CB  . ILE A 1 350 ? 187.697 242.624 298.733 1.00 22.88 ? 350 ILE A CB  1 
ATOM   2175 C  CG1 . ILE A 1 350 ? 188.090 241.161 298.741 1.00 22.88 ? 350 ILE A CG1 1 
ATOM   2176 C  CG2 . ILE A 1 350 ? 188.367 243.283 297.564 1.00 22.88 ? 350 ILE A CG2 1 
ATOM   2177 C  CD1 . ILE A 1 350 ? 187.630 240.437 297.549 1.00 22.88 ? 350 ILE A CD1 1 
ATOM   2178 N  N   . ALA A 1 351 ? 186.554 245.081 300.502 1.00 23.17 ? 351 ALA A N   1 
ATOM   2179 C  CA  . ALA A 1 351 ? 186.180 246.481 300.656 1.00 23.17 ? 351 ALA A CA  1 
ATOM   2180 C  C   . ALA A 1 351 ? 187.039 247.164 301.710 1.00 23.17 ? 351 ALA A C   1 
ATOM   2181 O  O   . ALA A 1 351 ? 187.460 248.307 301.526 1.00 23.17 ? 351 ALA A O   1 
ATOM   2182 C  CB  . ALA A 1 351 ? 184.703 246.600 301.009 1.00 23.17 ? 351 ALA A CB  1 
ATOM   2183 N  N   . ALA A 1 352 ? 187.313 246.479 302.823 1.00 24.32 ? 352 ALA A N   1 
ATOM   2184 C  CA  . ALA A 1 352 ? 188.186 247.041 303.855 1.00 24.32 ? 352 ALA A CA  1 
ATOM   2185 C  C   . ALA A 1 352 ? 189.601 247.265 303.337 1.00 24.32 ? 352 ALA A C   1 
ATOM   2186 O  O   . ALA A 1 352 ? 190.244 248.267 303.671 1.00 24.32 ? 352 ALA A O   1 
ATOM   2187 C  CB  . ALA A 1 352 ? 188.207 246.127 305.072 1.00 24.32 ? 352 ALA A CB  1 
ATOM   2188 N  N   . MET A 1 353 ? 190.120 246.320 302.556 1.00 24.69 ? 353 MET A N   1 
ATOM   2189 C  CA  . MET A 1 353 ? 191.442 246.482 301.961 1.00 24.69 ? 353 MET A CA  1 
ATOM   2190 C  C   . MET A 1 353 ? 191.459 247.662 301.010 1.00 24.69 ? 353 MET A C   1 
ATOM   2191 O  O   . MET A 1 353 ? 192.427 248.423 300.972 1.00 24.69 ? 353 MET A O   1 
ATOM   2192 C  CB  . MET A 1 353 ? 191.863 245.212 301.231 1.00 24.69 ? 353 MET A CB  1 
ATOM   2193 C  CG  . MET A 1 353 ? 192.008 244.016 302.122 1.00 24.69 ? 353 MET A CG  1 
ATOM   2194 S  SD  . MET A 1 353 ? 192.041 242.481 301.212 1.00 24.69 ? 353 MET A SD  1 
ATOM   2195 C  CE  . MET A 1 353 ? 192.924 242.992 299.773 1.00 24.69 ? 353 MET A CE  1 
ATOM   2196 N  N   . GLY A 1 354 ? 190.394 247.831 300.233 1.00 23.67 ? 354 GLY A N   1 
ATOM   2197 C  CA  . GLY A 1 354 ? 190.297 248.993 299.370 1.00 23.67 ? 354 GLY A CA  1 
ATOM   2198 C  C   . GLY A 1 354 ? 190.259 250.291 300.148 1.00 23.67 ? 354 GLY A C   1 
ATOM   2199 O  O   . GLY A 1 354 ? 190.856 251.286 299.742 1.00 23.67 ? 354 GLY A O   1 
ATOM   2200 N  N   . ARG A 1 355 ? 189.567 250.297 301.279 1.00 25.68 ? 355 ARG A N   1 
ATOM   2201 C  CA  . ARG A 1 355 ? 189.562 251.482 302.124 1.00 25.68 ? 355 ARG A CA  1 
ATOM   2202 C  C   . ARG A 1 355 ? 190.959 251.800 302.630 1.00 25.68 ? 355 ARG A C   1 
ATOM   2203 O  O   . ARG A 1 355 ? 191.354 252.968 302.700 1.00 25.68 ? 355 ARG A O   1 
ATOM   2204 C  CB  . ARG A 1 355 ? 188.603 251.288 303.285 1.00 25.68 ? 355 ARG A CB  1 
ATOM   2205 C  CG  . ARG A 1 355 ? 187.161 251.327 302.869 1.00 25.68 ? 355 ARG A CG  1 
ATOM   2206 C  CD  . ARG A 1 355 ? 186.307 251.741 304.020 1.00 25.68 ? 355 ARG A CD  1 
ATOM   2207 N  NE  . ARG A 1 355 ? 186.346 250.775 305.105 1.00 25.68 ? 355 ARG A NE  1 
ATOM   2208 C  CZ  . ARG A 1 355 ? 185.661 249.643 305.119 1.00 25.68 ? 355 ARG A CZ  1 
ATOM   2209 N  NH1 . ARG A 1 355 ? 184.865 249.306 304.123 1.00 25.68 ? 355 ARG A NH1 1 
ATOM   2210 N  NH2 . ARG A 1 355 ? 185.775 248.832 306.162 1.00 25.68 ? 355 ARG A NH2 1 
ATOM   2211 N  N   . GLU A 1 356 ? 191.710 250.777 303.025 1.00 24.64 ? 356 GLU A N   1 
ATOM   2212 C  CA  . GLU A 1 356 ? 193.094 250.994 303.444 1.00 24.64 ? 356 GLU A CA  1 
ATOM   2213 C  C   . GLU A 1 356 ? 193.950 251.529 302.302 1.00 24.64 ? 356 GLU A C   1 
ATOM   2214 O  O   . GLU A 1 356 ? 194.797 252.401 302.509 1.00 24.64 ? 356 GLU A O   1 
ATOM   2215 C  CB  . GLU A 1 356 ? 193.689 249.700 303.976 1.00 24.64 ? 356 GLU A CB  1 
ATOM   2216 C  CG  . GLU A 1 356 ? 192.942 249.138 305.140 1.00 24.64 ? 356 GLU A CG  1 
ATOM   2217 C  CD  . GLU A 1 356 ? 192.814 250.110 306.274 1.00 24.64 ? 356 GLU A CD  1 
ATOM   2218 O  OE1 . GLU A 1 356 ? 193.828 250.718 306.657 1.00 24.64 ? 356 GLU A OE1 1 
ATOM   2219 O  OE2 . GLU A 1 356 ? 191.690 250.261 306.793 1.00 24.64 ? 356 GLU A OE2 1 
ATOM   2220 N  N   . PHE A 1 357 ? 193.762 251.002 301.094 1.00 21.97 ? 357 PHE A N   1 
ATOM   2221 C  CA  . PHE A 1 357 ? 194.510 251.495 299.943 1.00 21.97 ? 357 PHE A CA  1 
ATOM   2222 C  C   . PHE A 1 357 ? 194.214 252.961 299.689 1.00 21.97 ? 357 PHE A C   1 
ATOM   2223 O  O   . PHE A 1 357 ? 195.122 253.743 299.403 1.00 21.97 ? 357 PHE A O   1 
ATOM   2224 C  CB  . PHE A 1 357 ? 194.174 250.690 298.690 1.00 21.97 ? 357 PHE A CB  1 
ATOM   2225 C  CG  . PHE A 1 357 ? 194.585 249.261 298.750 1.00 21.97 ? 357 PHE A CG  1 
ATOM   2226 C  CD1 . PHE A 1 357 ? 195.635 248.860 299.542 1.00 21.97 ? 357 PHE A CD1 1 
ATOM   2227 C  CD2 . PHE A 1 357 ? 193.924 248.314 298.000 1.00 21.97 ? 357 PHE A CD2 1 
ATOM   2228 C  CE1 . PHE A 1 357 ? 196.005 247.542 299.601 1.00 21.97 ? 357 PHE A CE1 1 
ATOM   2229 C  CE2 . PHE A 1 357 ? 194.299 246.993 298.051 1.00 21.97 ? 357 PHE A CE2 1 
ATOM   2230 C  CZ  . PHE A 1 357 ? 195.343 246.609 298.852 1.00 21.97 ? 357 PHE A CZ  1 
ATOM   2231 N  N   . ASN A 1 358 ? 192.943 253.351 299.770 1.00 21.33 ? 358 ASN A N   1 
ATOM   2232 C  CA  . ASN A 1 358 ? 192.581 254.751 299.578 1.00 21.33 ? 358 ASN A CA  1 
ATOM   2233 C  C   . ASN A 1 358 ? 193.173 255.632 300.667 1.00 21.33 ? 358 ASN A C   1 
ATOM   2234 O  O   . ASN A 1 358 ? 193.612 256.752 300.394 1.00 21.33 ? 358 ASN A O   1 
ATOM   2235 C  CB  . ASN A 1 358 ? 191.066 254.897 299.547 1.00 21.33 ? 358 ASN A CB  1 
ATOM   2236 C  CG  . ASN A 1 358 ? 190.433 254.027 298.515 1.00 21.33 ? 358 ASN A CG  1 
ATOM   2237 O  OD1 . ASN A 1 358 ? 191.027 253.740 297.488 1.00 21.33 ? 358 ASN A OD1 1 
ATOM   2238 N  ND2 . ASN A 1 358 ? 189.215 253.610 298.769 1.00 21.33 ? 358 ASN A ND2 1 
ATOM   2239 N  N   . ALA A 1 359 ? 193.188 255.150 301.907 1.00 21.95 ? 359 ALA A N   1 
ATOM   2240 C  CA  . ALA A 1 359 ? 193.791 255.919 302.990 1.00 21.95 ? 359 ALA A CA  1 
ATOM   2241 C  C   . ALA A 1 359 ? 195.282 256.126 302.760 1.00 21.95 ? 359 ALA A C   1 
ATOM   2242 O  O   . ALA A 1 359 ? 195.815 257.206 303.031 1.00 21.95 ? 359 ALA A O   1 
ATOM   2243 C  CB  . ALA A 1 359 ? 193.548 255.224 304.324 1.00 21.95 ? 359 ALA A CB  1 
ATOM   2244 N  N   . ARG A 1 360 ? 195.980 255.093 302.288 1.00 23.24 ? 360 ARG A N   1 
ATOM   2245 C  CA  . ARG A 1 360 ? 197.405 255.213 302.001 1.00 23.24 ? 360 ARG A CA  1 
ATOM   2246 C  C   . ARG A 1 360 ? 197.671 256.065 300.775 1.00 23.24 ? 360 ARG A C   1 
ATOM   2247 O  O   . ARG A 1 360 ? 198.803 256.513 300.581 1.00 23.24 ? 360 ARG A O   1 
ATOM   2248 C  CB  . ARG A 1 360 ? 198.038 253.844 301.792 1.00 23.24 ? 360 ARG A CB  1 
ATOM   2249 C  CG  . ARG A 1 360 ? 197.913 252.918 302.959 1.00 23.24 ? 360 ARG A CG  1 
ATOM   2250 C  CD  . ARG A 1 360 ? 198.578 253.462 304.174 1.00 23.24 ? 360 ARG A CD  1 
ATOM   2251 N  NE  . ARG A 1 360 ? 198.457 252.536 305.290 1.00 23.24 ? 360 ARG A NE  1 
ATOM   2252 C  CZ  . ARG A 1 360 ? 197.384 252.428 306.057 1.00 23.24 ? 360 ARG A CZ  1 
ATOM   2253 N  NH1 . ARG A 1 360 ? 196.313 253.169 305.852 1.00 23.24 ? 360 ARG A NH1 1 
ATOM   2254 N  NH2 . ARG A 1 360 ? 197.395 251.569 307.068 1.00 23.24 ? 360 ARG A NH2 1 
ATOM   2255 N  N   . GLY A 1 361 ? 196.662 256.296 299.945 1.00 21.60 ? 361 GLY A N   1 
ATOM   2256 C  CA  . GLY A 1 361 ? 196.843 257.095 298.758 1.00 21.60 ? 361 GLY A CA  1 
ATOM   2257 C  C   . GLY A 1 361 ? 197.404 256.363 297.571 1.00 21.60 ? 361 GLY A C   1 
ATOM   2258 O  O   . GLY A 1 361 ? 197.833 257.010 296.615 1.00 21.60 ? 361 GLY A O   1 
ATOM   2259 N  N   . LEU A 1 362 ? 197.433 255.041 297.597 1.00 21.22 ? 362 LEU A N   1 
ATOM   2260 C  CA  . LEU A 1 362 ? 197.962 254.264 296.490 1.00 21.22 ? 362 LEU A CA  1 
ATOM   2261 C  C   . LEU A 1 362 ? 196.841 253.516 295.787 1.00 21.22 ? 362 LEU A C   1 
ATOM   2262 O  O   . LEU A 1 362 ? 195.882 253.073 296.416 1.00 21.22 ? 362 LEU A O   1 
ATOM   2263 C  CB  . LEU A 1 362 ? 199.054 253.307 296.972 1.00 21.22 ? 362 LEU A CB  1 
ATOM   2264 C  CG  . LEU A 1 362 ? 198.766 252.410 298.161 1.00 21.22 ? 362 LEU A CG  1 
ATOM   2265 C  CD1 . LEU A 1 362 ? 198.368 251.060 297.684 1.00 21.22 ? 362 LEU A CD1 1 
ATOM   2266 C  CD2 . LEU A 1 362 ? 199.989 252.318 299.019 1.00 21.22 ? 362 LEU A CD2 1 
ATOM   2267 N  N   . TYR A 1 363 ? 196.956 253.417 294.471 1.00 23.53 ? 363 TYR A N   1 
ATOM   2268 C  CA  . TYR A 1 363 ? 195.948 252.785 293.634 1.00 23.53 ? 363 TYR A CA  1 
ATOM   2269 C  C   . TYR A 1 363 ? 196.547 251.537 293.014 1.00 23.53 ? 363 TYR A C   1 
ATOM   2270 O  O   . TYR A 1 363 ? 197.287 251.633 292.027 1.00 23.53 ? 363 TYR A O   1 
ATOM   2271 C  CB  . TYR A 1 363 ? 195.481 253.757 292.545 1.00 23.53 ? 363 TYR A CB  1 
ATOM   2272 C  CG  . TYR A 1 363 ? 194.295 253.299 291.749 1.00 23.53 ? 363 TYR A CG  1 
ATOM   2273 C  CD1 . TYR A 1 363 ? 193.019 253.422 292.241 1.00 23.53 ? 363 TYR A CD1 1 
ATOM   2274 C  CD2 . TYR A 1 363 ? 194.456 252.764 290.494 1.00 23.53 ? 363 TYR A CD2 1 
ATOM   2275 C  CE1 . TYR A 1 363 ? 191.943 253.005 291.516 1.00 23.53 ? 363 TYR A CE1 1 
ATOM   2276 C  CE2 . TYR A 1 363 ? 193.383 252.343 289.766 1.00 23.53 ? 363 TYR A CE2 1 
ATOM   2277 C  CZ  . TYR A 1 363 ? 192.129 252.467 290.278 1.00 23.53 ? 363 TYR A CZ  1 
ATOM   2278 O  OH  . TYR A 1 363 ? 191.051 252.048 289.544 1.00 23.53 ? 363 TYR A OH  1 
ATOM   2279 N  N   . PRO A 1 364 ? 196.285 250.355 293.556 1.00 27.83 ? 364 PRO A N   1 
ATOM   2280 C  CA  . PRO A 1 364 ? 196.908 249.147 293.022 1.00 27.83 ? 364 PRO A CA  1 
ATOM   2281 C  C   . PRO A 1 364 ? 196.370 248.808 291.652 1.00 27.83 ? 364 PRO A C   1 
ATOM   2282 O  O   . PRO A 1 364 ? 195.239 249.137 291.309 1.00 27.83 ? 364 PRO A O   1 
ATOM   2283 C  CB  . PRO A 1 364 ? 196.547 248.068 294.038 1.00 27.83 ? 364 PRO A CB  1 
ATOM   2284 C  CG  . PRO A 1 364 ? 195.758 248.703 295.064 1.00 27.83 ? 364 PRO A CG  1 
ATOM   2285 C  CD  . PRO A 1 364 ? 195.389 250.066 294.675 1.00 27.83 ? 364 PRO A CD  1 
ATOM   2286 N  N   . ASP A 1 365 ? 197.187 248.121 290.872 1.00 39.36 ? 365 ASP A N   1 
ATOM   2287 C  CA  . ASP A 1 365 ? 196.821 247.720 289.527 1.00 39.36 ? 365 ASP A CA  1 
ATOM   2288 C  C   . ASP A 1 365 ? 195.890 246.515 289.566 1.00 39.36 ? 365 ASP A C   1 
ATOM   2289 O  O   . ASP A 1 365 ? 195.675 245.897 290.611 1.00 39.36 ? 365 ASP A O   1 
ATOM   2290 C  CB  . ASP A 1 365 ? 198.077 247.384 288.730 1.00 39.36 ? 365 ASP A CB  1 
ATOM   2291 C  CG  . ASP A 1 365 ? 197.922 247.649 287.272 1.00 39.36 ? 365 ASP A CG  1 
ATOM   2292 O  OD1 . ASP A 1 365 ? 196.783 247.906 286.833 1.00 39.36 ? 365 ASP A OD1 1 
ATOM   2293 O  OD2 . ASP A 1 365 ? 198.930 247.558 286.553 1.00 39.36 ? 365 ASP A OD2 1 
ATOM   2294 N  N   . HIS A 1 366 ? 195.301 246.205 288.412 1.00 44.56 ? 366 HIS A N   1 
ATOM   2295 C  CA  . HIS A 1 366 ? 194.422 245.057 288.273 1.00 44.56 ? 366 HIS A CA  1 
ATOM   2296 C  C   . HIS A 1 366 ? 195.032 244.142 287.219 1.00 44.56 ? 366 HIS A C   1 
ATOM   2297 O  O   . HIS A 1 366 ? 195.526 244.610 286.191 1.00 44.56 ? 366 HIS A O   1 
ATOM   2298 C  CB  . HIS A 1 366 ? 193.016 245.485 287.844 1.00 44.56 ? 366 HIS A CB  1 
ATOM   2299 C  CG  . HIS A 1 366 ? 192.221 246.152 288.921 1.00 44.56 ? 366 HIS A CG  1 
ATOM   2300 N  ND1 . HIS A 1 366 ? 192.784 247.003 289.850 1.00 44.56 ? 366 HIS A ND1 1 
ATOM   2301 C  CD2 . HIS A 1 366 ? 190.903 246.092 289.217 1.00 44.56 ? 366 HIS A CD2 1 
ATOM   2302 C  CE1 . HIS A 1 366 ? 191.842 247.457 290.656 1.00 44.56 ? 366 HIS A CE1 1 
ATOM   2303 N  NE2 . HIS A 1 366 ? 190.694 246.908 290.301 1.00 44.56 ? 366 HIS A NE2 1 
ATOM   2304 N  N   . THR A 1 367 ? 195.008 242.842 287.461 1.00 47.86 ? 367 THR A N   1 
ATOM   2305 C  CA  . THR A 1 367 ? 195.577 241.878 286.524 1.00 47.86 ? 367 THR A CA  1 
ATOM   2306 C  C   . THR A 1 367 ? 194.465 240.976 285.992 1.00 47.86 ? 367 THR A C   1 
ATOM   2307 O  O   . THR A 1 367 ? 193.381 240.894 286.574 1.00 47.86 ? 367 THR A O   1 
ATOM   2308 C  CB  . THR A 1 367 ? 196.750 241.087 287.102 1.00 47.86 ? 367 THR A CB  1 
ATOM   2309 O  OG1 . THR A 1 367 ? 196.286 239.914 287.774 1.00 47.86 ? 367 THR A OG1 1 
ATOM   2310 C  CG2 . THR A 1 367 ? 197.491 241.942 288.081 1.00 47.86 ? 367 THR A CG2 1 
ATOM   2311 N  N   . ASP A 1 368 ? 194.751 240.317 284.867 1.00 57.11 ? 368 ASP A N   1 
ATOM   2312 C  CA  . ASP A 1 368 ? 193.804 239.501 284.107 1.00 57.11 ? 368 ASP A CA  1 
ATOM   2313 C  C   . ASP A 1 368 ? 194.119 238.020 284.286 1.00 57.11 ? 368 ASP A C   1 
ATOM   2314 O  O   . ASP A 1 368 ? 195.242 237.584 284.029 1.00 57.11 ? 368 ASP A O   1 
ATOM   2315 C  CB  . ASP A 1 368 ? 193.866 239.852 282.622 1.00 57.11 ? 368 ASP A CB  1 
ATOM   2316 C  CG  . ASP A 1 368 ? 193.159 241.129 282.301 1.00 57.11 ? 368 ASP A CG  1 
ATOM   2317 O  OD1 . ASP A 1 368 ? 192.907 241.935 283.223 1.00 57.11 ? 368 ASP A OD1 1 
ATOM   2318 O  OD2 . ASP A 1 368 ? 192.878 241.344 281.113 1.00 57.11 ? 368 ASP A OD2 1 
ATOM   2319 N  N   . LEU A 1 369 ? 193.130 237.258 284.754 1.00 56.17 ? 369 LEU A N   1 
ATOM   2320 C  CA  . LEU A 1 369 ? 193.195 235.802 284.786 1.00 56.17 ? 369 LEU A CA  1 
ATOM   2321 C  C   . LEU A 1 369 ? 192.020 235.273 283.985 1.00 56.17 ? 369 LEU A C   1 
ATOM   2322 O  O   . LEU A 1 369 ? 190.880 235.698 284.190 1.00 56.17 ? 369 LEU A O   1 
ATOM   2323 C  CB  . LEU A 1 369 ? 193.162 235.250 286.220 1.00 56.17 ? 369 LEU A CB  1 
ATOM   2324 C  CG  . LEU A 1 369 ? 192.011 235.566 287.175 1.00 56.17 ? 369 LEU A CG  1 
ATOM   2325 C  CD1 . LEU A 1 369 ? 190.943 234.505 287.109 1.00 56.17 ? 369 LEU A CD1 1 
ATOM   2326 C  CD2 . LEU A 1 369 ? 192.541 235.624 288.584 1.00 56.17 ? 369 LEU A CD2 1 
ATOM   2327 N  N   . GLY A 1 370 ? 192.316 234.379 283.048 1.00 59.37 ? 370 GLY A N   1 
ATOM   2328 C  CA  . GLY A 1 370 ? 191.293 233.801 282.196 1.00 59.37 ? 370 GLY A CA  1 
ATOM   2329 C  C   . GLY A 1 370 ? 190.522 234.822 281.387 1.00 59.37 ? 370 GLY A C   1 
ATOM   2330 O  O   . GLY A 1 370 ? 189.311 234.669 281.189 1.00 59.37 ? 370 GLY A O   1 
ATOM   2331 N  N   . GLY A 1 371 ? 191.198 235.874 280.928 1.00 61.21 ? 371 GLY A N   1 
ATOM   2332 C  CA  . GLY A 1 371 ? 190.521 236.941 280.221 1.00 61.21 ? 371 GLY A CA  1 
ATOM   2333 C  C   . GLY A 1 371 ? 189.573 237.750 281.066 1.00 61.21 ? 371 GLY A C   1 
ATOM   2334 O  O   . GLY A 1 371 ? 188.694 238.422 280.528 1.00 61.21 ? 371 GLY A O   1 
ATOM   2335 N  N   . GLN A 1 372 ? 189.727 237.696 282.383 1.00 58.24 ? 372 GLN A N   1 
ATOM   2336 C  CA  . GLN A 1 372 ? 188.860 238.394 283.316 1.00 58.24 ? 372 GLN A CA  1 
ATOM   2337 C  C   . GLN A 1 372 ? 189.728 239.286 284.187 1.00 58.24 ? 372 GLN A C   1 
ATOM   2338 O  O   . GLN A 1 372 ? 190.691 238.813 284.794 1.00 58.24 ? 372 GLN A O   1 
ATOM   2339 C  CB  . GLN A 1 372 ? 188.059 237.399 284.163 1.00 58.24 ? 372 GLN A CB  1 
ATOM   2340 C  CG  . GLN A 1 372 ? 187.002 238.030 285.039 1.00 58.24 ? 372 GLN A CG  1 
ATOM   2341 C  CD  . GLN A 1 372 ? 186.108 237.008 285.703 1.00 58.24 ? 372 GLN A CD  1 
ATOM   2342 O  OE1 . GLN A 1 372 ? 186.270 235.805 285.511 1.00 58.24 ? 372 GLN A OE1 1 
ATOM   2343 N  NE2 . GLN A 1 372 ? 185.164 237.484 286.504 1.00 58.24 ? 372 GLN A NE2 1 
ATOM   2344 N  N   . GLN A 1 373 ? 189.399 240.572 284.228 1.00 52.89 ? 373 GLN A N   1 
ATOM   2345 C  CA  . GLN A 1 373 ? 190.134 241.521 285.047 1.00 52.89 ? 373 GLN A CA  1 
ATOM   2346 C  C   . GLN A 1 373 ? 189.718 241.358 286.500 1.00 52.89 ? 373 GLN A C   1 
ATOM   2347 O  O   . GLN A 1 373 ? 188.544 241.140 286.803 1.00 52.89 ? 373 GLN A O   1 
ATOM   2348 C  CB  . GLN A 1 373 ? 189.889 242.947 284.564 1.00 52.89 ? 373 GLN A CB  1 
ATOM   2349 C  CG  . GLN A 1 373 ? 191.031 243.900 284.859 1.00 52.89 ? 373 GLN A CG  1 
ATOM   2350 C  CD  . GLN A 1 373 ? 190.641 245.352 284.709 1.00 52.89 ? 373 GLN A CD  1 
ATOM   2351 O  OE1 . GLN A 1 373 ? 191.038 246.195 285.507 1.00 52.89 ? 373 GLN A OE1 1 
ATOM   2352 N  NE2 . GLN A 1 373 ? 189.869 245.653 283.675 1.00 52.89 ? 373 GLN A NE2 1 
ATOM   2353 N  N   . VAL A 1 374 ? 190.686 241.491 287.400 1.00 44.61 ? 374 VAL A N   1 
ATOM   2354 C  CA  . VAL A 1 374 ? 190.462 241.288 288.829 1.00 44.61 ? 374 VAL A CA  1 
ATOM   2355 C  C   . VAL A 1 374 ? 191.445 242.141 289.624 1.00 44.61 ? 374 VAL A C   1 
ATOM   2356 O  O   . VAL A 1 374 ? 192.596 242.343 289.194 1.00 44.61 ? 374 VAL A O   1 
ATOM   2357 C  CB  . VAL A 1 374 ? 190.573 239.796 289.195 1.00 44.61 ? 374 VAL A CB  1 
ATOM   2358 C  CG1 . VAL A 1 374 ? 191.972 239.285 288.948 1.00 44.61 ? 374 VAL A CG1 1 
ATOM   2359 C  CG2 . VAL A 1 374 ? 190.142 239.543 290.628 1.00 44.61 ? 374 VAL A CG2 1 
ATOM   2360 N  N   . PRO A 1 375 ? 191.006 242.709 290.748 1.00 37.73 ? 375 PRO A N   1 
ATOM   2361 C  CA  . PRO A 1 375 ? 191.920 243.444 291.625 1.00 37.73 ? 375 PRO A CA  1 
ATOM   2362 C  C   . PRO A 1 375 ? 193.054 242.574 292.118 1.00 37.73 ? 375 PRO A C   1 
ATOM   2363 O  O   . PRO A 1 375 ? 192.892 241.379 292.342 1.00 37.73 ? 375 PRO A O   1 
ATOM   2364 C  CB  . PRO A 1 375 ? 191.021 243.858 292.792 1.00 37.73 ? 375 PRO A CB  1 
ATOM   2365 C  CG  . PRO A 1 375 ? 189.696 243.957 292.217 1.00 37.73 ? 375 PRO A CG  1 
ATOM   2366 C  CD  . PRO A 1 375 ? 189.605 242.921 291.133 1.00 37.73 ? 375 PRO A CD  1 
ATOM   2367 N  N   . ALA A 1 376 ? 194.223 243.182 292.262 1.00 26.55 ? 376 ALA A N   1 
ATOM   2368 C  CA  . ALA A 1 376 ? 195.387 242.424 292.665 1.00 26.55 ? 376 ALA A CA  1 
ATOM   2369 C  C   . ALA A 1 376 ? 196.276 243.302 293.522 1.00 26.55 ? 376 ALA A C   1 
ATOM   2370 O  O   . ALA A 1 376 ? 196.159 244.526 293.519 1.00 26.55 ? 376 ALA A O   1 
ATOM   2371 C  CB  . ALA A 1 376 ? 196.152 241.926 291.445 1.00 26.55 ? 376 ALA A CB  1 
ATOM   2372 N  N   . TRP A 1 377 ? 197.147 242.654 294.287 1.00 22.10 ? 377 TRP A N   1 
ATOM   2373 C  CA  . TRP A 1 377 ? 198.164 243.332 295.074 1.00 22.10 ? 377 TRP A CA  1 
ATOM   2374 C  C   . TRP A 1 377 ? 199.517 242.764 294.690 1.00 22.10 ? 377 TRP A C   1 
ATOM   2375 O  O   . TRP A 1 377 ? 199.736 241.558 294.810 1.00 22.10 ? 377 TRP A O   1 
ATOM   2376 C  CB  . TRP A 1 377 ? 197.907 243.146 296.563 1.00 22.10 ? 377 TRP A CB  1 
ATOM   2377 C  CG  . TRP A 1 377 ? 198.924 243.769 297.425 1.00 22.10 ? 377 TRP A CG  1 
ATOM   2378 C  CD1 . TRP A 1 377 ? 199.828 243.133 298.199 1.00 22.10 ? 377 TRP A CD1 1 
ATOM   2379 C  CD2 . TRP A 1 377 ? 199.149 245.165 297.611 1.00 22.10 ? 377 TRP A CD2 1 
ATOM   2380 N  NE1 . TRP A 1 377 ? 200.609 244.039 298.854 1.00 22.10 ? 377 TRP A NE1 1 
ATOM   2381 C  CE2 . TRP A 1 377 ? 200.204 245.297 298.510 1.00 22.10 ? 377 TRP A CE2 1 
ATOM   2382 C  CE3 . TRP A 1 377 ? 198.556 246.316 297.103 1.00 22.10 ? 377 TRP A CE3 1 
ATOM   2383 C  CZ2 . TRP A 1 377 ? 200.679 246.528 298.912 1.00 22.10 ? 377 TRP A CZ2 1 
ATOM   2384 C  CZ3 . TRP A 1 377 ? 199.036 247.534 297.504 1.00 22.10 ? 377 TRP A CZ3 1 
ATOM   2385 C  CH2 . TRP A 1 377 ? 200.081 247.633 298.397 1.00 22.10 ? 377 TRP A CH2 1 
ATOM   2386 N  N   . ARG A 1 378 ? 200.418 243.625 294.236 1.00 22.38 ? 378 ARG A N   1 
ATOM   2387 C  CA  . ARG A 1 378 ? 201.726 243.206 293.757 1.00 22.38 ? 378 ARG A CA  1 
ATOM   2388 C  C   . ARG A 1 378 ? 201.597 242.169 292.649 1.00 22.38 ? 378 ARG A C   1 
ATOM   2389 O  O   . ARG A 1 378 ? 202.421 241.264 292.533 1.00 22.38 ? 378 ARG A O   1 
ATOM   2390 C  CB  . ARG A 1 378 ? 202.606 242.666 294.882 1.00 22.38 ? 378 ARG A CB  1 
ATOM   2391 C  CG  . ARG A 1 378 ? 202.743 243.572 296.077 1.00 22.38 ? 378 ARG A CG  1 
ATOM   2392 C  CD  . ARG A 1 378 ? 203.328 244.899 295.726 1.00 22.38 ? 378 ARG A CD  1 
ATOM   2393 N  NE  . ARG A 1 378 ? 203.703 245.635 296.924 1.00 22.38 ? 378 ARG A NE  1 
ATOM   2394 C  CZ  . ARG A 1 378 ? 203.951 246.935 296.954 1.00 22.38 ? 378 ARG A CZ  1 
ATOM   2395 N  NH1 . ARG A 1 378 ? 203.870 247.677 295.866 1.00 22.38 ? 378 ARG A NH1 1 
ATOM   2396 N  NH2 . ARG A 1 378 ? 204.267 247.506 298.109 1.00 22.38 ? 378 ARG A NH2 1 
ATOM   2397 N  N   . GLY A 1 379 ? 200.557 242.276 291.837 1.00 24.23 ? 379 GLY A N   1 
ATOM   2398 C  CA  . GLY A 1 379 ? 200.338 241.348 290.755 1.00 24.23 ? 379 GLY A CA  1 
ATOM   2399 C  C   . GLY A 1 379 ? 199.681 240.046 291.136 1.00 24.23 ? 379 GLY A C   1 
ATOM   2400 O  O   . GLY A 1 379 ? 199.430 239.222 290.252 1.00 24.23 ? 379 GLY A O   1 
ATOM   2401 N  N   . VAL A 1 380 ? 199.372 239.833 292.410 1.00 23.12 ? 380 VAL A N   1 
ATOM   2402 C  CA  . VAL A 1 380 ? 198.740 238.601 292.872 1.00 23.12 ? 380 VAL A CA  1 
ATOM   2403 C  C   . VAL A 1 380 ? 197.241 238.865 292.977 1.00 23.12 ? 380 VAL A C   1 
ATOM   2404 O  O   . VAL A 1 380 ? 196.827 239.656 293.836 1.00 23.12 ? 380 VAL A O   1 
ATOM   2405 C  CB  . VAL A 1 380 ? 199.327 238.147 294.213 1.00 23.12 ? 380 VAL A CB  1 
ATOM   2406 C  CG1 . VAL A 1 380 ? 198.537 237.034 294.774 1.00 23.12 ? 380 VAL A CG1 1 
ATOM   2407 C  CG2 . VAL A 1 380 ? 200.749 237.692 294.030 1.00 23.12 ? 380 VAL A CG2 1 
ATOM   2408 N  N   . PRO A 1 381 ? 196.405 238.216 292.172 1.00 24.02 ? 381 PRO A N   1 
ATOM   2409 C  CA  . PRO A 1 381 ? 194.981 238.552 292.164 1.00 24.02 ? 381 PRO A CA  1 
ATOM   2410 C  C   . PRO A 1 381 ? 194.314 238.285 293.497 1.00 24.02 ? 381 PRO A C   1 
ATOM   2411 O  O   . PRO A 1 381 ? 194.666 237.356 294.218 1.00 24.02 ? 381 PRO A O   1 
ATOM   2412 C  CB  . PRO A 1 381 ? 194.414 237.654 291.064 1.00 24.02 ? 381 PRO A CB  1 
ATOM   2413 C  CG  . PRO A 1 381 ? 195.378 236.593 290.901 1.00 24.02 ? 381 PRO A CG  1 
ATOM   2414 C  CD  . PRO A 1 381 ? 196.714 237.181 291.178 1.00 24.02 ? 381 PRO A CD  1 
ATOM   2415 N  N   . ILE A 1 382 ? 193.338 239.120 293.823 1.00 24.43 ? 382 ILE A N   1 
ATOM   2416 C  CA  . ILE A 1 382 ? 192.546 238.977 295.035 1.00 24.43 ? 382 ILE A CA  1 
ATOM   2417 C  C   . ILE A 1 382 ? 191.147 238.564 294.620 1.00 24.43 ? 382 ILE A C   1 
ATOM   2418 O  O   . ILE A 1 382 ? 190.432 239.332 293.968 1.00 24.43 ? 382 ILE A O   1 
ATOM   2419 C  CB  . ILE A 1 382 ? 192.514 240.263 295.861 1.00 24.43 ? 382 ILE A CB  1 
ATOM   2420 C  CG1 . ILE A 1 382 ? 193.926 240.731 296.163 1.00 24.43 ? 382 ILE A CG1 1 
ATOM   2421 C  CG2 . ILE A 1 382 ? 191.739 240.040 297.126 1.00 24.43 ? 382 ILE A CG2 1 
ATOM   2422 C  CD1 . ILE A 1 382 ? 194.004 242.176 296.470 1.00 24.43 ? 382 ILE A CD1 1 
ATOM   2423 N  N   . LEU A 1 383 ? 190.751 237.362 295.012 1.00 24.91 ? 383 LEU A N   1 
ATOM   2424 C  CA  . LEU A 1 383 ? 189.507 236.768 294.592 1.00 24.91 ? 383 LEU A CA  1 
ATOM   2425 C  C   . LEU A 1 383 ? 188.512 236.764 295.732 1.00 24.91 ? 383 LEU A C   1 
ATOM   2426 O  O   . LEU A 1 383 ? 188.880 236.436 296.864 1.00 24.91 ? 383 LEU A O   1 
ATOM   2427 C  CB  . LEU A 1 383 ? 189.765 235.348 294.124 1.00 24.91 ? 383 LEU A CB  1 
ATOM   2428 C  CG  . LEU A 1 383 ? 190.850 235.215 293.071 1.00 24.91 ? 383 LEU A CG  1 
ATOM   2429 C  CD1 . LEU A 1 383 ? 191.061 233.769 292.758 1.00 24.91 ? 383 LEU A CD1 1 
ATOM   2430 C  CD2 . LEU A 1 383 ? 190.452 235.954 291.834 1.00 24.91 ? 383 LEU A CD2 1 
ATOM   2431 N  N   . PRO A 1 384 ? 187.264 237.152 295.487 1.00 25.68 ? 384 PRO A N   1 
ATOM   2432 C  CA  . PRO A 1 384 ? 186.259 237.148 296.549 1.00 25.68 ? 384 PRO A CA  1 
ATOM   2433 C  C   . PRO A 1 384 ? 185.713 235.754 296.821 1.00 25.68 ? 384 PRO A C   1 
ATOM   2434 O  O   . PRO A 1 384 ? 185.495 234.958 295.907 1.00 25.68 ? 384 PRO A O   1 
ATOM   2435 C  CB  . PRO A 1 384 ? 185.170 238.067 295.991 1.00 25.68 ? 384 PRO A CB  1 
ATOM   2436 C  CG  . PRO A 1 384 ? 185.274 237.887 294.547 1.00 25.68 ? 384 PRO A CG  1 
ATOM   2437 C  CD  . PRO A 1 384 ? 186.714 237.672 294.228 1.00 25.68 ? 384 PRO A CD  1 
ATOM   2438 N  N   . CYS A 1 385 ? 185.484 235.461 298.095 1.00 26.02 ? 385 CYS A N   1 
ATOM   2439 C  CA  . CYS A 1 385 ? 184.881 234.196 298.497 1.00 26.02 ? 385 CYS A CA  1 
ATOM   2440 C  C   . CYS A 1 385 ? 183.926 234.500 299.635 1.00 26.02 ? 385 CYS A C   1 
ATOM   2441 O  O   . CYS A 1 385 ? 184.356 234.921 300.708 1.00 26.02 ? 385 CYS A O   1 
ATOM   2442 C  CB  . CYS A 1 385 ? 185.922 233.166 298.924 1.00 26.02 ? 385 CYS A CB  1 
ATOM   2443 S  SG  . CYS A 1 385 ? 185.315 231.454 298.941 1.00 26.02 ? 385 CYS A SG  1 
ATOM   2444 N  N   . GLY A 1 386 ? 182.641 234.291 299.404 1.00 25.76 ? 386 GLY A N   1 
ATOM   2445 C  CA  . GLY A 1 386 ? 181.653 234.530 300.428 1.00 25.76 ? 386 GLY A CA  1 
ATOM   2446 C  C   . GLY A 1 386 ? 181.547 233.451 301.467 1.00 25.76 ? 386 GLY A C   1 
ATOM   2447 O  O   . GLY A 1 386 ? 180.812 233.620 302.442 1.00 25.76 ? 386 GLY A O   1 
ATOM   2448 N  N   . LYS A 1 387 ? 182.270 232.352 301.290 1.00 26.67 ? 387 LYS A N   1 
ATOM   2449 C  CA  . LYS A 1 387 ? 182.238 231.251 302.238 1.00 26.67 ? 387 LYS A CA  1 
ATOM   2450 C  C   . LYS A 1 387 ? 183.195 231.445 303.401 1.00 26.67 ? 387 LYS A C   1 
ATOM   2451 O  O   . LYS A 1 387 ? 183.194 230.625 304.320 1.00 26.67 ? 387 LYS A O   1 
ATOM   2452 C  CB  . LYS A 1 387 ? 182.558 229.944 301.528 1.00 26.67 ? 387 LYS A CB  1 
ATOM   2453 C  CG  . LYS A 1 387 ? 181.759 229.729 300.280 1.00 26.67 ? 387 LYS A CG  1 
ATOM   2454 C  CD  . LYS A 1 387 ? 180.395 229.180 300.604 1.00 26.67 ? 387 LYS A CD  1 
ATOM   2455 C  CE  . LYS A 1 387 ? 179.455 229.307 299.432 1.00 26.67 ? 387 LYS A CE  1 
ATOM   2456 N  NZ  . LYS A 1 387 ? 180.179 229.299 298.144 1.00 26.67 ? 387 LYS A NZ  1 
ATOM   2457 N  N   . ILE A 1 388 ? 184.019 232.483 303.383 1.00 25.63 ? 388 ILE A N   1 
ATOM   2458 C  CA  . ILE A 1 388 ? 184.899 232.765 304.509 1.00 25.63 ? 388 ILE A CA  1 
ATOM   2459 C  C   . ILE A 1 388 ? 184.076 233.411 305.617 1.00 25.63 ? 388 ILE A C   1 
ATOM   2460 O  O   . ILE A 1 388 ? 183.461 234.460 305.395 1.00 25.63 ? 388 ILE A O   1 
ATOM   2461 C  CB  . ILE A 1 388 ? 186.078 233.651 304.093 1.00 25.63 ? 388 ILE A CB  1 
ATOM   2462 C  CG1 . ILE A 1 388 ? 186.928 232.920 303.069 1.00 25.63 ? 388 ILE A CG1 1 
ATOM   2463 C  CG2 . ILE A 1 388 ? 186.931 233.966 305.288 1.00 25.63 ? 388 ILE A CG2 1 
ATOM   2464 C  CD1 . ILE A 1 388 ? 188.132 233.647 302.663 1.00 25.63 ? 388 ILE A CD1 1 
ATOM   2465 N  N   . PRO A 1 389 ? 184.036 232.835 306.813 1.00 29.41 ? 389 PRO A N   1 
ATOM   2466 C  CA  . PRO A 1 389 ? 183.131 233.341 307.846 1.00 29.41 ? 389 PRO A CA  1 
ATOM   2467 C  C   . PRO A 1 389 ? 183.501 234.733 308.338 1.00 29.41 ? 389 PRO A C   1 
ATOM   2468 O  O   . PRO A 1 389 ? 184.660 235.146 308.310 1.00 29.41 ? 389 PRO A O   1 
ATOM   2469 C  CB  . PRO A 1 389 ? 183.279 232.311 308.969 1.00 29.41 ? 389 PRO A CB  1 
ATOM   2470 C  CG  . PRO A 1 389 ? 184.589 231.704 308.747 1.00 29.41 ? 389 PRO A CG  1 
ATOM   2471 C  CD  . PRO A 1 389 ? 184.797 231.671 307.282 1.00 29.41 ? 389 PRO A CD  1 
ATOM   2472 N  N   . ILE A 1 390 ? 182.480 235.465 308.775 1.00 33.27 ? 390 ILE A N   1 
ATOM   2473 C  CA  . ILE A 1 390 ? 182.631 236.752 309.443 1.00 33.27 ? 390 ILE A CA  1 
ATOM   2474 C  C   . ILE A 1 390 ? 182.173 236.565 310.881 1.00 33.27 ? 390 ILE A C   1 
ATOM   2475 O  O   . ILE A 1 390 ? 181.026 236.179 311.126 1.00 33.27 ? 390 ILE A O   1 
ATOM   2476 C  CB  . ILE A 1 390 ? 181.807 237.862 308.771 1.00 33.27 ? 390 ILE A CB  1 
ATOM   2477 C  CG1 . ILE A 1 390 ? 181.946 237.872 307.253 1.00 33.27 ? 390 ILE A CG1 1 
ATOM   2478 C  CG2 . ILE A 1 390 ? 182.217 239.209 309.299 1.00 33.27 ? 390 ILE A CG2 1 
ATOM   2479 C  CD1 . ILE A 1 390 ? 183.247 238.385 306.764 1.00 33.27 ? 390 ILE A CD1 1 
ATOM   2480 N  N   . THR A 1 391 ? 183.054 236.846 311.827 1.00 39.76 ? 391 THR A N   1 
ATOM   2481 C  CA  . THR A 1 391 ? 182.751 236.660 313.235 1.00 39.76 ? 391 THR A CA  1 
ATOM   2482 C  C   . THR A 1 391 ? 181.796 237.749 313.720 1.00 39.76 ? 391 THR A C   1 
ATOM   2483 O  O   . THR A 1 391 ? 181.656 238.792 313.079 1.00 39.76 ? 391 THR A O   1 
ATOM   2484 C  CB  . THR A 1 391 ? 184.021 236.665 314.075 1.00 39.76 ? 391 THR A CB  1 
ATOM   2485 O  OG1 . THR A 1 391 ? 184.742 237.875 313.851 1.00 39.76 ? 391 THR A OG1 1 
ATOM   2486 C  CG2 . THR A 1 391 ? 184.895 235.496 313.699 1.00 39.76 ? 391 THR A CG2 1 
ATOM   2487 N  N   . PRO A 1 392 ? 181.094 237.514 314.832 1.00 44.88 ? 392 PRO A N   1 
ATOM   2488 C  CA  . PRO A 1 392 ? 180.236 238.574 315.385 1.00 44.88 ? 392 PRO A CA  1 
ATOM   2489 C  C   . PRO A 1 392 ? 180.996 239.842 315.725 1.00 44.88 ? 392 PRO A C   1 
ATOM   2490 O  O   . PRO A 1 392 ? 180.403 240.926 315.701 1.00 44.88 ? 392 PRO A O   1 
ATOM   2491 C  CB  . PRO A 1 392 ? 179.633 237.924 316.637 1.00 44.88 ? 392 PRO A CB  1 
ATOM   2492 C  CG  . PRO A 1 392 ? 180.461 236.717 316.896 1.00 44.88 ? 392 PRO A CG  1 
ATOM   2493 C  CD  . PRO A 1 392 ? 180.919 236.252 315.565 1.00 44.88 ? 392 PRO A CD  1 
ATOM   2494 N  N   . GLU A 1 393 ? 182.279 239.747 316.062 1.00 45.56 ? 393 GLU A N   1 
ATOM   2495 C  CA  . GLU A 1 393 ? 183.101 240.931 316.273 1.00 45.56 ? 393 GLU A CA  1 
ATOM   2496 C  C   . GLU A 1 393 ? 183.540 241.580 314.966 1.00 45.56 ? 393 GLU A C   1 
ATOM   2497 O  O   . GLU A 1 393 ? 184.395 242.466 314.993 1.00 45.56 ? 393 GLU A O   1 
ATOM   2498 C  CB  . GLU A 1 393 ? 184.331 240.591 317.115 1.00 45.56 ? 393 GLU A CB  1 
ATOM   2499 C  CG  . GLU A 1 393 ? 184.084 239.549 318.180 1.00 45.56 ? 393 GLU A CG  1 
ATOM   2500 C  CD  . GLU A 1 393 ? 184.469 238.157 317.734 1.00 45.56 ? 393 GLU A CD  1 
ATOM   2501 O  OE1 . GLU A 1 393 ? 185.256 238.038 316.773 1.00 45.56 ? 393 GLU A OE1 1 
ATOM   2502 O  OE2 . GLU A 1 393 ? 183.979 237.181 318.338 1.00 45.56 ? 393 GLU A OE2 1 
ATOM   2503 N  N   . ARG A 1 394 ? 182.969 241.157 313.837 1.00 42.61 ? 394 ARG A N   1 
ATOM   2504 C  CA  . ARG A 1 394 ? 183.238 241.748 312.524 1.00 42.61 ? 394 ARG A CA  1 
ATOM   2505 C  C   . ARG A 1 394 ? 184.705 241.637 312.129 1.00 42.61 ? 394 ARG A C   1 
ATOM   2506 O  O   . ARG A 1 394 ? 185.291 242.576 311.594 1.00 42.61 ? 394 ARG A O   1 
ATOM   2507 C  CB  . ARG A 1 394 ? 182.781 243.207 312.471 1.00 42.61 ? 394 ARG A CB  1 
ATOM   2508 C  CG  . ARG A 1 394 ? 181.321 243.393 312.101 1.00 42.61 ? 394 ARG A CG  1 
ATOM   2509 C  CD  . ARG A 1 394 ? 180.744 244.650 312.717 1.00 42.61 ? 394 ARG A CD  1 
ATOM   2510 N  NE  . ARG A 1 394 ? 181.028 244.747 314.142 1.00 42.61 ? 394 ARG A NE  1 
ATOM   2511 C  CZ  . ARG A 1 394 ? 181.699 245.740 314.711 1.00 42.61 ? 394 ARG A CZ  1 
ATOM   2512 N  NH1 . ARG A 1 394 ? 182.168 246.755 314.003 1.00 42.61 ? 394 ARG A NH1 1 
ATOM   2513 N  NH2 . ARG A 1 394 ? 181.900 245.717 316.025 1.00 42.61 ? 394 ARG A NH2 1 
ATOM   2514 N  N   . THR A 1 395 ? 185.304 240.482 312.397 1.00 36.37 ? 395 THR A N   1 
ATOM   2515 C  CA  . THR A 1 395 ? 186.676 240.186 312.015 1.00 36.37 ? 395 THR A CA  1 
ATOM   2516 C  C   . THR A 1 395 ? 186.682 238.965 311.114 1.00 36.37 ? 395 THR A C   1 
ATOM   2517 O  O   . THR A 1 395 ? 186.084 237.945 311.452 1.00 36.37 ? 395 THR A O   1 
ATOM   2518 C  CB  . THR A 1 395 ? 187.564 239.928 313.230 1.00 36.37 ? 395 THR A CB  1 
ATOM   2519 O  OG1 . THR A 1 395 ? 187.171 238.705 313.858 1.00 36.37 ? 395 THR A OG1 1 
ATOM   2520 C  CG2 . THR A 1 395 ? 187.461 241.059 314.226 1.00 36.37 ? 395 THR A CG2 1 
ATOM   2521 N  N   . SER A 1 396 ? 187.356 239.064 309.983 1.00 29.41 ? 396 SER A N   1 
ATOM   2522 C  CA  . SER A 1 396 ? 187.455 237.983 309.015 1.00 29.41 ? 396 SER A CA  1 
ATOM   2523 C  C   . SER A 1 396 ? 188.926 237.602 308.835 1.00 29.41 ? 396 SER A C   1 
ATOM   2524 O  O   . SER A 1 396 ? 189.794 238.031 309.592 1.00 29.41 ? 396 SER A O   1 
ATOM   2525 C  CB  . SER A 1 396 ? 186.791 238.389 307.704 1.00 29.41 ? 396 SER A CB  1 
ATOM   2526 O  OG  . SER A 1 396 ? 186.786 237.324 306.783 1.00 29.41 ? 396 SER A OG  1 
ATOM   2527 N  N   . SER A 1 397 ? 189.197 236.752 307.850 1.00 25.27 ? 397 SER A N   1 
ATOM   2528 C  CA  . SER A 1 397 ? 190.549 236.291 307.571 1.00 25.27 ? 397 SER A CA  1 
ATOM   2529 C  C   . SER A 1 397 ? 190.812 236.309 306.072 1.00 25.27 ? 397 SER A C   1 
ATOM   2530 O  O   . SER A 1 397 ? 189.889 236.286 305.259 1.00 25.27 ? 397 SER A O   1 
ATOM   2531 C  CB  . SER A 1 397 ? 190.787 234.891 308.136 1.00 25.27 ? 397 SER A CB  1 
ATOM   2532 O  OG  . SER A 1 397 ? 189.893 233.960 307.574 1.00 25.27 ? 397 SER A OG  1 
ATOM   2533 N  N   . ILE A 1 398 ? 192.092 236.374 305.713 1.00 22.27 ? 398 ILE A N   1 
ATOM   2534 C  CA  . ILE A 1 398 ? 192.533 236.384 304.323 1.00 22.27 ? 398 ILE A CA  1 
ATOM   2535 C  C   . ILE A 1 398 ? 193.447 235.190 304.098 1.00 22.27 ? 398 ILE A C   1 
ATOM   2536 O  O   . ILE A 1 398 ? 194.257 234.853 304.960 1.00 22.27 ? 398 ILE A O   1 
ATOM   2537 C  CB  . ILE A 1 398 ? 193.262 237.695 303.971 1.00 22.27 ? 398 ILE A CB  1 
ATOM   2538 C  CG1 . ILE A 1 398 ? 192.449 238.893 304.430 1.00 22.27 ? 398 ILE A CG1 1 
ATOM   2539 C  CG2 . ILE A 1 398 ? 193.520 237.791 302.497 1.00 22.27 ? 398 ILE A CG2 1 
ATOM   2540 C  CD1 . ILE A 1 398 ? 193.059 240.189 304.077 1.00 22.27 ? 398 ILE A CD1 1 
ATOM   2541 N  N   . LEU A 1 399 ? 193.316 234.546 302.945 1.00 22.14 ? 399 LEU A N   1 
ATOM   2542 C  CA  . LEU A 1 399 ? 194.106 233.373 302.598 1.00 22.14 ? 399 LEU A CA  1 
ATOM   2543 C  C   . LEU A 1 399 ? 194.997 233.702 301.415 1.00 22.14 ? 399 LEU A C   1 
ATOM   2544 O  O   . LEU A 1 399 ? 194.514 234.143 300.379 1.00 22.14 ? 399 LEU A O   1 
ATOM   2545 C  CB  . LEU A 1 399 ? 193.210 232.190 302.248 1.00 22.14 ? 399 LEU A CB  1 
ATOM   2546 C  CG  . LEU A 1 399 ? 192.727 231.251 303.340 1.00 22.14 ? 399 LEU A CG  1 
ATOM   2547 C  CD1 . LEU A 1 399 ? 191.736 231.930 304.225 1.00 22.14 ? 399 LEU A CD1 1 
ATOM   2548 C  CD2 . LEU A 1 399 ? 192.079 230.092 302.671 1.00 22.14 ? 399 LEU A CD2 1 
ATOM   2549 N  N   . ALA A 1 400 ? 196.287 233.456 301.552 1.00 21.14 ? 400 ALA A N   1 
ATOM   2550 C  CA  . ALA A 1 400 ? 197.229 233.564 300.450 1.00 21.14 ? 400 ALA A CA  1 
ATOM   2551 C  C   . ALA A 1 400 ? 197.741 232.183 300.109 1.00 21.14 ? 400 ALA A C   1 
ATOM   2552 O  O   . ALA A 1 400 ? 198.298 231.504 300.969 1.00 21.14 ? 400 ALA A O   1 
ATOM   2553 C  CB  . ALA A 1 400 ? 198.387 234.482 300.811 1.00 21.14 ? 400 ALA A CB  1 
ATOM   2554 N  N   . LEU A 1 401 ? 197.539 231.752 298.873 1.00 22.36 ? 401 LEU A N   1 
ATOM   2555 C  CA  . LEU A 1 401 ? 197.843 230.363 298.583 1.00 22.36 ? 401 LEU A CA  1 
ATOM   2556 C  C   . LEU A 1 401 ? 198.309 230.176 297.155 1.00 22.36 ? 401 LEU A C   1 
ATOM   2557 O  O   . LEU A 1 401 ? 197.835 230.855 296.239 1.00 22.36 ? 401 LEU A O   1 
ATOM   2558 C  CB  . LEU A 1 401 ? 196.631 229.477 298.869 1.00 22.36 ? 401 LEU A CB  1 
ATOM   2559 C  CG  . LEU A 1 401 ? 195.436 229.444 297.936 1.00 22.36 ? 401 LEU A CG  1 
ATOM   2560 C  CD1 . LEU A 1 401 ? 195.518 228.212 297.101 1.00 22.36 ? 401 LEU A CD1 1 
ATOM   2561 C  CD2 . LEU A 1 401 ? 194.155 229.469 298.745 1.00 22.36 ? 401 LEU A CD2 1 
ATOM   2562 N  N   . ARG A 1 402 ? 199.303 229.305 296.997 1.00 25.45 ? 402 ARG A N   1 
ATOM   2563 C  CA  . ARG A 1 402 ? 199.802 228.925 295.689 1.00 25.45 ? 402 ARG A CA  1 
ATOM   2564 C  C   . ARG A 1 402 ? 199.268 227.540 295.343 1.00 25.45 ? 402 ARG A C   1 
ATOM   2565 O  O   . ARG A 1 402 ? 199.174 226.661 296.202 1.00 25.45 ? 402 ARG A O   1 
ATOM   2566 C  CB  . ARG A 1 402 ? 201.327 228.934 295.645 1.00 25.45 ? 402 ARG A CB  1 
ATOM   2567 C  CG  . ARG A 1 402 ? 201.991 227.679 296.100 1.00 25.45 ? 402 ARG A CG  1 
ATOM   2568 C  CD  . ARG A 1 402 ? 203.466 227.704 295.790 1.00 25.45 ? 402 ARG A CD  1 
ATOM   2569 N  NE  . ARG A 1 402 ? 204.189 226.768 296.634 1.00 25.45 ? 402 ARG A NE  1 
ATOM   2570 C  CZ  . ARG A 1 402 ? 204.792 227.107 297.760 1.00 25.45 ? 402 ARG A CZ  1 
ATOM   2571 N  NH1 . ARG A 1 402 ? 204.779 228.349 298.198 1.00 25.45 ? 402 ARG A NH1 1 
ATOM   2572 N  NH2 . ARG A 1 402 ? 205.418 226.176 298.468 1.00 25.45 ? 402 ARG A NH2 1 
ATOM   2573 N  N   . THR A 1 403 ? 198.930 227.349 294.078 1.00 30.17 ? 403 THR A N   1 
ATOM   2574 C  CA  . THR A 1 403 ? 198.316 226.124 293.608 1.00 30.17 ? 403 THR A CA  1 
ATOM   2575 C  C   . THR A 1 403 ? 199.216 225.442 292.600 1.00 30.17 ? 403 THR A C   1 
ATOM   2576 O  O   . THR A 1 403 ? 199.791 226.099 291.730 1.00 30.17 ? 403 THR A O   1 
ATOM   2577 C  CB  . THR A 1 403 ? 196.975 226.402 292.960 1.00 30.17 ? 403 THR A CB  1 
ATOM   2578 O  OG1 . THR A 1 403 ? 197.185 227.001 291.678 1.00 30.17 ? 403 THR A OG1 1 
ATOM   2579 C  CG2 . THR A 1 403 ? 196.178 227.331 293.802 1.00 30.17 ? 403 THR A CG2 1 
ATOM   2580 N  N   . GLY A 1 404 ? 199.330 224.131 292.707 1.00 36.82 ? 404 GLY A N   1 
ATOM   2581 C  CA  . GLY A 1 404 ? 200.075 223.396 291.713 1.00 36.82 ? 404 GLY A CA  1 
ATOM   2582 C  C   . GLY A 1 404 ? 200.509 222.051 292.222 1.00 36.82 ? 404 GLY A C   1 
ATOM   2583 O  O   . GLY A 1 404 ? 200.489 221.765 293.416 1.00 36.82 ? 404 GLY A O   1 
ATOM   2584 N  N   . GLU A 1 405 ? 200.882 221.198 291.279 1.00 43.30 ? 405 GLU A N   1 
ATOM   2585 C  CA  . GLU A 1 405 ? 201.437 219.889 291.579 1.00 43.30 ? 405 GLU A CA  1 
ATOM   2586 C  C   . GLU A 1 405 ? 202.935 219.841 291.347 1.00 43.30 ? 405 GLU A C   1 
ATOM   2587 O  O   . GLU A 1 405 ? 203.668 219.319 292.186 1.00 43.30 ? 405 GLU A O   1 
ATOM   2588 C  CB  . GLU A 1 405 ? 200.758 218.824 290.709 1.00 43.30 ? 405 GLU A CB  1 
ATOM   2589 C  CG  . GLU A 1 405 ? 201.287 217.417 290.893 1.00 43.30 ? 405 GLU A CG  1 
ATOM   2590 C  CD  . GLU A 1 405 ? 200.902 216.817 292.218 1.00 43.30 ? 405 GLU A CD  1 
ATOM   2591 O  OE1 . GLU A 1 405 ? 199.831 217.172 292.737 1.00 43.30 ? 405 GLU A OE1 1 
ATOM   2592 O  OE2 . GLU A 1 405 ? 201.673 215.996 292.751 1.00 43.30 ? 405 GLU A OE2 1 
ATOM   2593 N  N   . GLU A 1 406 ? 203.410 220.403 290.233 1.00 45.18 ? 406 GLU A N   1 
ATOM   2594 C  CA  . GLU A 1 406 ? 204.846 220.468 289.990 1.00 45.18 ? 406 GLU A CA  1 
ATOM   2595 C  C   . GLU A 1 406 ? 205.531 221.391 290.986 1.00 45.18 ? 406 GLU A C   1 
ATOM   2596 O  O   . GLU A 1 406 ? 206.652 221.114 291.427 1.00 45.18 ? 406 GLU A O   1 
ATOM   2597 C  CB  . GLU A 1 406 ? 205.130 220.888 288.543 1.00 45.18 ? 406 GLU A CB  1 
ATOM   2598 C  CG  . GLU A 1 406 ? 204.744 222.310 288.094 1.00 45.18 ? 406 GLU A CG  1 
ATOM   2599 C  CD  . GLU A 1 406 ? 203.333 222.746 288.473 1.00 45.18 ? 406 GLU A CD  1 
ATOM   2600 O  OE1 . GLU A 1 406 ? 203.056 223.963 288.418 1.00 45.18 ? 406 GLU A OE1 1 
ATOM   2601 O  OE2 . GLU A 1 406 ? 202.487 221.883 288.794 1.00 45.18 ? 406 GLU A OE2 1 
ATOM   2602 N  N   . ASP A 1 407 ? 204.882 222.494 291.348 1.00 41.81 ? 407 ASP A N   1 
ATOM   2603 C  CA  . ASP A 1 407 ? 205.327 223.339 292.447 1.00 41.81 ? 407 ASP A CA  1 
ATOM   2604 C  C   . ASP A 1 407 ? 204.494 222.954 293.657 1.00 41.81 ? 407 ASP A C   1 
ATOM   2605 O  O   . ASP A 1 407 ? 203.267 223.070 293.627 1.00 41.81 ? 407 ASP A O   1 
ATOM   2606 C  CB  . ASP A 1 407 ? 205.161 224.820 292.126 1.00 41.81 ? 407 ASP A CB  1 
ATOM   2607 C  CG  . ASP A 1 407 ? 203.812 225.135 291.547 1.00 41.81 ? 407 ASP A CG  1 
ATOM   2608 O  OD1 . ASP A 1 407 ? 203.134 224.194 291.104 1.00 41.81 ? 407 ASP A OD1 1 
ATOM   2609 O  OD2 . ASP A 1 407 ? 203.423 226.319 291.535 1.00 41.81 ? 407 ASP A OD2 1 
ATOM   2610 N  N   . GLN A 1 408 ? 205.154 222.525 294.723 1.00 35.01 ? 408 GLN A N   1 
ATOM   2611 C  CA  . GLN A 1 408 ? 204.428 222.006 295.870 1.00 35.01 ? 408 GLN A CA  1 
ATOM   2612 C  C   . GLN A 1 408 ? 203.480 223.048 296.437 1.00 35.01 ? 408 GLN A C   1 
ATOM   2613 O  O   . GLN A 1 408 ? 203.910 224.036 297.034 1.00 35.01 ? 408 GLN A O   1 
ATOM   2614 C  CB  . GLN A 1 408 ? 205.402 221.523 296.939 1.00 35.01 ? 408 GLN A CB  1 
ATOM   2615 C  CG  . GLN A 1 408 ? 206.269 220.363 296.502 1.00 35.01 ? 408 GLN A CG  1 
ATOM   2616 C  CD  . GLN A 1 408 ? 207.714 220.759 296.314 1.00 35.01 ? 408 GLN A CD  1 
ATOM   2617 O  OE1 . GLN A 1 408 ? 208.270 221.510 297.112 1.00 35.01 ? 408 GLN A OE1 1 
ATOM   2618 N  NE2 . GLN A 1 408 ? 208.335 220.249 295.260 1.00 35.01 ? 408 GLN A NE2 1 
ATOM   2619 N  N   . GLY A 1 409 ? 202.186 222.827 296.256 1.00 30.38 ? 409 GLY A N   1 
ATOM   2620 C  CA  . GLY A 1 409 ? 201.194 223.772 296.701 1.00 30.38 ? 409 GLY A CA  1 
ATOM   2621 C  C   . GLY A 1 409 ? 199.924 223.103 297.163 1.00 30.38 ? 409 GLY A C   1 
ATOM   2622 O  O   . GLY A 1 409 ? 199.979 222.115 297.892 1.00 30.38 ? 409 GLY A O   1 
ATOM   2623 N  N   . VAL A 1 410 ? 198.777 223.608 296.730 1.00 28.56 ? 410 VAL A N   1 
ATOM   2624 C  CA  . VAL A 1 410 ? 197.477 223.082 297.126 1.00 28.56 ? 410 VAL A CA  1 
ATOM   2625 C  C   . VAL A 1 410 ? 196.810 222.451 295.918 1.00 28.56 ? 410 VAL A C   1 
ATOM   2626 O  O   . VAL A 1 410 ? 196.663 223.092 294.873 1.00 28.56 ? 410 VAL A O   1 
ATOM   2627 C  CB  . VAL A 1 410 ? 196.587 224.179 297.724 1.00 28.56 ? 410 VAL A CB  1 
ATOM   2628 C  CG1 . VAL A 1 410 ? 195.364 223.571 298.353 1.00 28.56 ? 410 VAL A CG1 1 
ATOM   2629 C  CG2 . VAL A 1 410 ? 197.356 224.961 298.731 1.00 28.56 ? 410 VAL A CG2 1 
ATOM   2630 N  N   . ILE A 1 411 ? 196.393 221.207 296.065 1.00 29.32 ? 411 ILE A N   1 
ATOM   2631 C  CA  . ILE A 1 411 ? 195.739 220.489 294.986 1.00 29.32 ? 411 ILE A CA  1 
ATOM   2632 C  C   . ILE A 1 411 ? 194.368 220.030 295.443 1.00 29.32 ? 411 ILE A C   1 
ATOM   2633 O  O   . ILE A 1 411 ? 194.101 219.868 296.637 1.00 29.32 ? 411 ILE A O   1 
ATOM   2634 C  CB  . ILE A 1 411 ? 196.563 219.284 294.512 1.00 29.32 ? 411 ILE A CB  1 
ATOM   2635 C  CG1 . ILE A 1 411 ? 196.962 218.436 295.707 1.00 29.32 ? 411 ILE A CG1 1 
ATOM   2636 C  CG2 . ILE A 1 411 ? 197.770 219.743 293.748 1.00 29.32 ? 411 ILE A CG2 1 
ATOM   2637 C  CD1 . ILE A 1 411 ? 197.540 217.130 295.326 1.00 29.32 ? 411 ILE A CD1 1 
ATOM   2638 N  N   . GLY A 1 412 ? 193.486 219.854 294.473 1.00 30.29 ? 412 GLY A N   1 
ATOM   2639 C  CA  . GLY A 1 412 ? 192.180 219.311 294.733 1.00 30.29 ? 412 GLY A CA  1 
ATOM   2640 C  C   . GLY A 1 412 ? 192.105 217.852 294.341 1.00 30.29 ? 412 GLY A C   1 
ATOM   2641 O  O   . GLY A 1 412 ? 192.175 217.511 293.162 1.00 30.29 ? 412 GLY A O   1 
ATOM   2642 N  N   . LEU A 1 413 ? 192.000 216.979 295.328 1.00 31.01 ? 413 LEU A N   1 
ATOM   2643 C  CA  . LEU A 1 413 ? 191.894 215.552 295.089 1.00 31.01 ? 413 LEU A CA  1 
ATOM   2644 C  C   . LEU A 1 413 ? 190.470 215.227 294.667 1.00 31.01 ? 413 LEU A C   1 
ATOM   2645 O  O   . LEU A 1 413 ? 189.520 215.559 295.376 1.00 31.01 ? 413 LEU A O   1 
ATOM   2646 C  CB  . LEU A 1 413 ? 192.267 214.785 296.348 1.00 31.01 ? 413 LEU A CB  1 
ATOM   2647 C  CG  . LEU A 1 413 ? 193.484 215.304 297.085 1.00 31.01 ? 413 LEU A CG  1 
ATOM   2648 C  CD1 . LEU A 1 413 ? 193.533 214.696 298.447 1.00 31.01 ? 413 LEU A CD1 1 
ATOM   2649 C  CD2 . LEU A 1 413 ? 194.703 214.944 296.301 1.00 31.01 ? 413 LEU A CD2 1 
ATOM   2650 N  N   . ARG A 1 414 ? 190.320 214.591 293.514 1.00 36.02 ? 414 ARG A N   1 
ATOM   2651 C  CA  . ARG A 1 414 ? 189.003 214.266 292.996 1.00 36.02 ? 414 ARG A CA  1 
ATOM   2652 C  C   . ARG A 1 414 ? 189.134 213.105 292.034 1.00 36.02 ? 414 ARG A C   1 
ATOM   2653 O  O   . ARG A 1 414 ? 190.068 213.066 291.238 1.00 36.02 ? 414 ARG A O   1 
ATOM   2654 C  CB  . ARG A 1 414 ? 188.392 215.469 292.287 1.00 36.02 ? 414 ARG A CB  1 
ATOM   2655 C  CG  . ARG A 1 414 ? 187.280 215.138 291.348 1.00 36.02 ? 414 ARG A CG  1 
ATOM   2656 C  CD  . ARG A 1 414 ? 187.122 216.205 290.299 1.00 36.02 ? 414 ARG A CD  1 
ATOM   2657 N  NE  . ARG A 1 414 ? 188.095 216.073 289.228 1.00 36.02 ? 414 ARG A NE  1 
ATOM   2658 C  CZ  . ARG A 1 414 ? 188.073 216.798 288.120 1.00 36.02 ? 414 ARG A CZ  1 
ATOM   2659 N  NH1 . ARG A 1 414 ? 187.142 217.714 287.914 1.00 36.02 ? 414 ARG A NH1 1 
ATOM   2660 N  NH2 . ARG A 1 414 ? 189.006 216.597 287.196 1.00 36.02 ? 414 ARG A NH2 1 
ATOM   2661 N  N   . GLN A 1 415 ? 188.202 212.164 292.111 1.00 39.93 ? 415 GLN A N   1 
ATOM   2662 C  CA  . GLN A 1 415 ? 188.217 210.976 291.270 1.00 39.93 ? 415 GLN A CA  1 
ATOM   2663 C  C   . GLN A 1 415 ? 187.109 211.072 290.232 1.00 39.93 ? 415 GLN A C   1 
ATOM   2664 O  O   . GLN A 1 415 ? 185.936 211.212 290.584 1.00 39.93 ? 415 GLN A O   1 
ATOM   2665 C  CB  . GLN A 1 415 ? 188.039 209.718 292.113 1.00 39.93 ? 415 GLN A CB  1 
ATOM   2666 C  CG  . GLN A 1 415 ? 188.369 208.444 291.389 1.00 39.93 ? 415 GLN A CG  1 
ATOM   2667 C  CD  . GLN A 1 415 ? 188.859 207.385 292.319 1.00 39.93 ? 415 GLN A CD  1 
ATOM   2668 O  OE1 . GLN A 1 415 ? 189.269 207.672 293.435 1.00 39.93 ? 415 GLN A OE1 1 
ATOM   2669 N  NE2 . GLN A 1 415 ? 188.812 206.143 291.875 1.00 39.93 ? 415 GLN A NE2 1 
ATOM   2670 N  N   . THR A 1 416 ? 187.483 210.997 288.964 1.00 44.20 ? 416 THR A N   1 
ATOM   2671 C  CA  . THR A 1 416 ? 186.543 210.996 287.859 1.00 44.20 ? 416 THR A CA  1 
ATOM   2672 C  C   . THR A 1 416 ? 186.363 209.572 287.336 1.00 44.20 ? 416 THR A C   1 
ATOM   2673 O  O   . THR A 1 416 ? 186.845 208.602 287.926 1.00 44.20 ? 416 THR A O   1 
ATOM   2674 C  CB  . THR A 1 416 ? 187.005 211.948 286.760 1.00 44.20 ? 416 THR A CB  1 
ATOM   2675 O  OG1 . THR A 1 416 ? 188.344 211.625 286.377 1.00 44.20 ? 416 THR A OG1 1 
ATOM   2676 C  CG2 . THR A 1 416 ? 186.955 213.376 287.249 1.00 44.20 ? 416 THR A CG2 1 
ATOM   2677 N  N   . GLY A 1 417 ? 185.666 209.439 286.214 1.00 45.46 ? 417 GLY A N   1 
ATOM   2678 C  CA  . GLY A 1 417 ? 185.389 208.125 285.662 1.00 45.46 ? 417 GLY A CA  1 
ATOM   2679 C  C   . GLY A 1 417 ? 184.468 207.293 286.525 1.00 45.46 ? 417 GLY A C   1 
ATOM   2680 O  O   . GLY A 1 417 ? 184.665 206.079 286.650 1.00 45.46 ? 417 GLY A O   1 
ATOM   2681 N  N   . LEU A 1 418 ? 183.469 207.921 287.129 1.00 44.80 ? 418 LEU A N   1 
ATOM   2682 C  CA  . LEU A 1 418 ? 182.518 207.224 287.968 1.00 44.80 ? 418 LEU A CA  1 
ATOM   2683 C  C   . LEU A 1 418 ? 181.601 206.353 287.113 1.00 44.80 ? 418 LEU A C   1 
ATOM   2684 O  O   . LEU A 1 418 ? 181.484 206.564 285.905 1.00 44.80 ? 418 LEU A O   1 
ATOM   2685 C  CB  . LEU A 1 418 ? 181.713 208.223 288.794 1.00 44.80 ? 418 LEU A CB  1 
ATOM   2686 C  CG  . LEU A 1 418 ? 182.565 209.082 289.719 1.00 44.80 ? 418 LEU A CG  1 
ATOM   2687 C  CD1 . LEU A 1 418 ? 181.694 209.921 290.611 1.00 44.80 ? 418 LEU A CD1 1 
ATOM   2688 C  CD2 . LEU A 1 418 ? 183.494 208.220 290.540 1.00 44.80 ? 418 LEU A CD2 1 
ATOM   2689 N  N   . PRO A 1 419 ? 180.964 205.341 287.716 1.00 48.19 ? 419 PRO A N   1 
ATOM   2690 C  CA  . PRO A 1 419 ? 180.187 204.388 286.906 1.00 48.19 ? 419 PRO A CA  1 
ATOM   2691 C  C   . PRO A 1 419 ? 179.107 205.028 286.052 1.00 48.19 ? 419 PRO A C   1 
ATOM   2692 O  O   . PRO A 1 419 ? 178.853 204.553 284.939 1.00 48.19 ? 419 PRO A O   1 
ATOM   2693 C  CB  . PRO A 1 419 ? 179.587 203.456 287.964 1.00 48.19 ? 419 PRO A CB  1 
ATOM   2694 C  CG  . PRO A 1 419 ? 180.522 203.527 289.098 1.00 48.19 ? 419 PRO A CG  1 
ATOM   2695 C  CD  . PRO A 1 419 ? 181.048 204.915 289.123 1.00 48.19 ? 419 PRO A CD  1 
ATOM   2696 N  N   . ASP A 1 420 ? 178.442 206.071 286.536 1.00 46.36 ? 420 ASP A N   1 
ATOM   2697 C  CA  . ASP A 1 420 ? 177.350 206.704 285.789 1.00 46.36 ? 420 ASP A CA  1 
ATOM   2698 C  C   . ASP A 1 420 ? 177.439 208.212 286.003 1.00 46.36 ? 420 ASP A C   1 
ATOM   2699 O  O   . ASP A 1 420 ? 176.861 208.748 286.950 1.00 46.36 ? 420 ASP A O   1 
ATOM   2700 C  CB  . ASP A 1 420 ? 176.006 206.144 286.207 1.00 46.36 ? 420 ASP A CB  1 
ATOM   2701 C  CG  . ASP A 1 420 ? 175.898 205.978 287.689 1.00 46.36 ? 420 ASP A CG  1 
ATOM   2702 O  OD1 . ASP A 1 420 ? 176.822 206.428 288.395 1.00 46.36 ? 420 ASP A OD1 1 
ATOM   2703 O  OD2 . ASP A 1 420 ? 174.900 205.390 288.146 1.00 46.36 ? 420 ASP A OD2 1 
ATOM   2704 N  N   . GLU A 1 421 ? 178.109 208.894 285.083 1.00 48.57 ? 421 GLU A N   1 
ATOM   2705 C  CA  . GLU A 1 421 ? 178.439 210.302 285.231 1.00 48.57 ? 421 GLU A CA  1 
ATOM   2706 C  C   . GLU A 1 421 ? 177.500 211.152 284.392 1.00 48.57 ? 421 GLU A C   1 
ATOM   2707 O  O   . GLU A 1 421 ? 177.450 211.008 283.168 1.00 48.57 ? 421 GLU A O   1 
ATOM   2708 C  CB  . GLU A 1 421 ? 179.880 210.569 284.812 1.00 48.57 ? 421 GLU A CB  1 
ATOM   2709 C  CG  . GLU A 1 421 ? 180.899 209.727 285.505 1.00 48.57 ? 421 GLU A CG  1 
ATOM   2710 C  CD  . GLU A 1 421 ? 182.302 210.203 285.222 1.00 48.57 ? 421 GLU A CD  1 
ATOM   2711 O  OE1 . GLU A 1 421 ? 182.659 210.332 284.034 1.00 48.57 ? 421 GLU A OE1 1 
ATOM   2712 O  OE2 . GLU A 1 421 ? 183.054 210.432 286.186 1.00 48.57 ? 421 GLU A OE2 1 
ATOM   2713 N  N   . TYR A 1 422 ? 176.762 212.038 285.054 1.00 51.41 ? 422 TYR A N   1 
ATOM   2714 C  CA  . TYR A 1 422 ? 176.113 213.131 284.351 1.00 51.41 ? 422 TYR A CA  1 
ATOM   2715 C  C   . TYR A 1 422 ? 177.104 214.226 283.996 1.00 51.41 ? 422 TYR A C   1 
ATOM   2716 O  O   . TYR A 1 422 ? 176.973 214.866 282.949 1.00 51.41 ? 422 TYR A O   1 
ATOM   2717 C  CB  . TYR A 1 422 ? 174.998 213.703 285.227 1.00 51.41 ? 422 TYR A CB  1 
ATOM   2718 C  CG  . TYR A 1 422 ? 174.239 214.865 284.636 1.00 51.41 ? 422 TYR A CG  1 
ATOM   2719 C  CD1 . TYR A 1 422 ? 174.655 216.172 284.847 1.00 51.41 ? 422 TYR A CD1 1 
ATOM   2720 C  CD2 . TYR A 1 422 ? 173.095 214.659 283.891 1.00 51.41 ? 422 TYR A CD2 1 
ATOM   2721 C  CE1 . TYR A 1 422 ? 173.963 217.234 284.313 1.00 51.41 ? 422 TYR A CE1 1 
ATOM   2722 C  CE2 . TYR A 1 422 ? 172.396 215.715 283.356 1.00 51.41 ? 422 TYR A CE2 1 
ATOM   2723 C  CZ  . TYR A 1 422 ? 172.833 217.001 283.568 1.00 51.41 ? 422 TYR A CZ  1 
ATOM   2724 O  OH  . TYR A 1 422 ? 172.134 218.058 283.032 1.00 51.41 ? 422 TYR A OH  1 
ATOM   2725 N  N   . GLU A 1 423 ? 178.111 214.392 284.849 1.00 50.52 ? 423 GLU A N   1 
ATOM   2726 C  CA  . GLU A 1 423 ? 179.173 215.355 284.613 1.00 50.52 ? 423 GLU A CA  1 
ATOM   2727 C  C   . GLU A 1 423 ? 180.457 214.637 284.975 1.00 50.52 ? 423 GLU A C   1 
ATOM   2728 O  O   . GLU A 1 423 ? 180.425 213.680 285.740 1.00 50.52 ? 423 GLU A O   1 
ATOM   2729 C  CB  . GLU A 1 423 ? 179.000 216.588 285.478 1.00 50.52 ? 423 GLU A CB  1 
ATOM   2730 C  CG  . GLU A 1 423 ? 177.781 217.416 285.122 1.00 50.52 ? 423 GLU A CG  1 
ATOM   2731 C  CD  . GLU A 1 423 ? 177.596 218.599 286.047 1.00 50.52 ? 423 GLU A CD  1 
ATOM   2732 O  OE1 . GLU A 1 423 ? 178.301 218.668 287.075 1.00 50.52 ? 423 GLU A OE1 1 
ATOM   2733 O  OE2 . GLU A 1 423 ? 176.747 219.461 285.745 1.00 50.52 ? 423 GLU A OE2 1 
ATOM   2734 N  N   . PRO A 1 424 ? 181.601 215.088 284.448 1.00 49.96 ? 424 PRO A N   1 
ATOM   2735 C  CA  . PRO A 1 424 ? 182.872 214.374 284.667 1.00 49.96 ? 424 PRO A CA  1 
ATOM   2736 C  C   . PRO A 1 424 ? 183.197 214.042 286.116 1.00 49.96 ? 424 PRO A C   1 
ATOM   2737 O  O   . PRO A 1 424 ? 183.829 213.012 286.368 1.00 49.96 ? 424 PRO A O   1 
ATOM   2738 C  CB  . PRO A 1 424 ? 183.911 215.333 284.074 1.00 49.96 ? 424 PRO A CB  1 
ATOM   2739 C  CG  . PRO A 1 424 ? 183.136 216.324 283.236 1.00 49.96 ? 424 PRO A CG  1 
ATOM   2740 C  CD  . PRO A 1 424 ? 181.686 215.980 283.285 1.00 49.96 ? 424 PRO A CD  1 
ATOM   2741 N  N   . GLY A 1 425 ? 182.811 214.869 287.075 1.00 44.83 ? 425 GLY A N   1 
ATOM   2742 C  CA  . GLY A 1 425 ? 183.089 214.544 288.459 1.00 44.83 ? 425 GLY A CA  1 
ATOM   2743 C  C   . GLY A 1 425 ? 181.899 214.002 289.224 1.00 44.83 ? 425 GLY A C   1 
ATOM   2744 O  O   . GLY A 1 425 ? 182.043 213.561 290.366 1.00 44.83 ? 425 GLY A O   1 
ATOM   2745 N  N   . LEU A 1 426 ? 180.730 213.991 288.597 1.00 41.50 ? 426 LEU A N   1 
ATOM   2746 C  CA  . LEU A 1 426 ? 179.475 213.685 289.265 1.00 41.50 ? 426 LEU A CA  1 
ATOM   2747 C  C   . LEU A 1 426 ? 179.023 212.266 288.975 1.00 41.50 ? 426 LEU A C   1 
ATOM   2748 O  O   . LEU A 1 426 ? 179.498 211.608 288.052 1.00 41.50 ? 426 LEU A O   1 
ATOM   2749 C  CB  . LEU A 1 426 ? 178.388 214.659 288.826 1.00 41.50 ? 426 LEU A CB  1 
ATOM   2750 C  CG  . LEU A 1 426 ? 178.055 215.844 289.710 1.00 41.50 ? 426 LEU A CG  1 
ATOM   2751 C  CD1 . LEU A 1 426 ? 176.767 216.385 289.224 1.00 41.50 ? 426 LEU A CD1 1 
ATOM   2752 C  CD2 . LEU A 1 426 ? 177.934 215.461 291.146 1.00 41.50 ? 426 LEU A CD2 1 
ATOM   2753 N  N   . SER A 1 427 ? 178.047 211.816 289.757 1.00 39.48 ? 427 SER A N   1 
ATOM   2754 C  CA  . SER A 1 427 ? 177.415 210.524 289.521 1.00 39.48 ? 427 SER A CA  1 
ATOM   2755 C  C   . SER A 1 427 ? 175.981 210.579 290.013 1.00 39.48 ? 427 SER A C   1 
ATOM   2756 O  O   . SER A 1 427 ? 175.746 210.700 291.215 1.00 39.48 ? 427 SER A O   1 
ATOM   2757 C  CB  . SER A 1 427 ? 178.181 209.419 290.235 1.00 39.48 ? 427 SER A CB  1 
ATOM   2758 O  OG  . SER A 1 427 ? 177.511 208.180 290.156 1.00 39.48 ? 427 SER A OG  1 
ATOM   2759 N  N   . VAL A 1 428 ? 175.028 210.506 289.092 1.00 37.77 ? 428 VAL A N   1 
ATOM   2760 C  CA  . VAL A 1 428 ? 173.615 210.434 289.438 1.00 37.77 ? 428 VAL A CA  1 
ATOM   2761 C  C   . VAL A 1 428 ? 173.115 209.049 289.061 1.00 37.77 ? 428 VAL A C   1 
ATOM   2762 O  O   . VAL A 1 428 ? 173.302 208.597 287.928 1.00 37.77 ? 428 VAL A O   1 
ATOM   2763 C  CB  . VAL A 1 428 ? 172.806 211.550 288.752 1.00 37.77 ? 428 VAL A CB  1 
ATOM   2764 C  CG1 . VAL A 1 428 ? 173.044 211.553 287.275 1.00 37.77 ? 428 VAL A CG1 1 
ATOM   2765 C  CG2 . VAL A 1 428 ? 171.335 211.383 289.039 1.00 37.77 ? 428 VAL A CG2 1 
ATOM   2766 N  N   . ARG A 1 429 ? 172.516 208.362 290.026 1.00 36.06 ? 429 ARG A N   1 
ATOM   2767 C  CA  . ARG A 1 429 ? 172.048 206.999 289.829 1.00 36.06 ? 429 ARG A CA  1 
ATOM   2768 C  C   . ARG A 1 429 ? 170.637 206.853 290.374 1.00 36.06 ? 429 ARG A C   1 
ATOM   2769 O  O   . ARG A 1 429 ? 170.343 207.306 291.478 1.00 36.06 ? 429 ARG A O   1 
ATOM   2770 C  CB  . ARG A 1 429 ? 172.988 206.000 290.481 1.00 36.06 ? 429 ARG A CB  1 
ATOM   2771 C  CG  . ARG A 1 429 ? 173.285 206.275 291.908 1.00 36.06 ? 429 ARG A CG  1 
ATOM   2772 C  CD  . ARG A 1 429 ? 174.036 205.126 292.531 1.00 36.06 ? 429 ARG A CD  1 
ATOM   2773 N  NE  . ARG A 1 429 ? 175.393 204.976 292.023 1.00 36.06 ? 429 ARG A NE  1 
ATOM   2774 C  CZ  . ARG A 1 429 ? 175.854 203.888 291.426 1.00 36.06 ? 429 ARG A CZ  1 
ATOM   2775 N  NH1 . ARG A 1 429 ? 175.085 202.833 291.232 1.00 36.06 ? 429 ARG A NH1 1 
ATOM   2776 N  NH2 . ARG A 1 429 ? 177.128 203.841 291.053 1.00 36.06 ? 429 ARG A NH2 1 
ATOM   2777 N  N   . PHE A 1 430 ? 169.783 206.174 289.616 1.00 31.29 ? 430 PHE A N   1 
ATOM   2778 C  CA  . PHE A 1 430 ? 168.416 205.923 290.047 1.00 31.29 ? 430 PHE A CA  1 
ATOM   2779 C  C   . PHE A 1 430 ? 168.394 204.958 291.224 1.00 31.29 ? 430 PHE A C   1 
ATOM   2780 O  O   . PHE A 1 430 ? 169.001 203.888 291.175 1.00 31.29 ? 430 PHE A O   1 
ATOM   2781 C  CB  . PHE A 1 430 ? 167.622 205.362 288.866 1.00 31.29 ? 430 PHE A CB  1 
ATOM   2782 C  CG  . PHE A 1 430 ? 166.387 204.611 289.248 1.00 31.29 ? 430 PHE A CG  1 
ATOM   2783 C  CD1 . PHE A 1 430 ? 165.233 205.278 289.586 1.00 31.29 ? 430 PHE A CD1 1 
ATOM   2784 C  CD2 . PHE A 1 430 ? 166.377 203.234 289.256 1.00 31.29 ? 430 PHE A CD2 1 
ATOM   2785 C  CE1 . PHE A 1 430 ? 164.104 204.582 289.937 1.00 31.29 ? 430 PHE A CE1 1 
ATOM   2786 C  CE2 . PHE A 1 430 ? 165.249 202.542 289.605 1.00 31.29 ? 430 PHE A CE2 1 
ATOM   2787 C  CZ  . PHE A 1 430 ? 164.116 203.213 289.946 1.00 31.29 ? 430 PHE A CZ  1 
ATOM   2788 N  N   . MET A 1 431 ? 167.693 205.340 292.289 1.00 29.97 ? 431 MET A N   1 
ATOM   2789 C  CA  . MET A 1 431 ? 167.654 204.556 293.513 1.00 29.97 ? 431 MET A CA  1 
ATOM   2790 C  C   . MET A 1 431 ? 166.461 203.605 293.524 1.00 29.97 ? 431 MET A C   1 
ATOM   2791 O  O   . MET A 1 431 ? 166.632 202.386 293.580 1.00 29.97 ? 431 MET A O   1 
ATOM   2792 C  CB  . MET A 1 431 ? 167.593 205.501 294.716 1.00 29.97 ? 431 MET A CB  1 
ATOM   2793 C  CG  . MET A 1 431 ? 168.781 206.418 294.852 1.00 29.97 ? 431 MET A CG  1 
ATOM   2794 S  SD  . MET A 1 431 ? 169.231 206.756 296.545 1.00 29.97 ? 431 MET A SD  1 
ATOM   2795 C  CE  . MET A 1 431 ? 167.662 206.579 297.346 1.00 29.97 ? 431 MET A CE  1 
ATOM   2796 N  N   . ASN A 1 432 ? 165.251 204.149 293.452 1.00 32.19 ? 432 ASN A N   1 
ATOM   2797 C  CA  . ASN A 1 432 ? 164.022 203.368 293.496 1.00 32.19 ? 432 ASN A CA  1 
ATOM   2798 C  C   . ASN A 1 432 ? 162.854 204.301 293.220 1.00 32.19 ? 432 ASN A C   1 
ATOM   2799 O  O   . ASN A 1 432 ? 163.014 205.519 293.154 1.00 32.19 ? 432 ASN A O   1 
ATOM   2800 C  CB  . ASN A 1 432 ? 163.844 202.670 294.841 1.00 32.19 ? 432 ASN A CB  1 
ATOM   2801 C  CG  . ASN A 1 432 ? 163.800 203.639 295.989 1.00 32.19 ? 432 ASN A CG  1 
ATOM   2802 O  OD1 . ASN A 1 432 ? 162.752 204.173 296.324 1.00 32.19 ? 432 ASN A OD1 1 
ATOM   2803 N  ND2 . ASN A 1 432 ? 164.942 203.861 296.613 1.00 32.19 ? 432 ASN A ND2 1 
ATOM   2804 N  N   . ILE A 1 433 ? 161.677 203.710 293.040 1.00 34.66 ? 433 ILE A N   1 
ATOM   2805 C  CA  . ILE A 1 433 ? 160.424 204.446 292.945 1.00 34.66 ? 433 ILE A CA  1 
ATOM   2806 C  C   . ILE A 1 433 ? 159.554 204.011 294.110 1.00 34.66 ? 433 ILE A C   1 
ATOM   2807 O  O   . ILE A 1 433 ? 159.319 202.815 294.303 1.00 34.66 ? 433 ILE A O   1 
ATOM   2808 C  CB  . ILE A 1 433 ? 159.712 204.212 291.609 1.00 34.66 ? 433 ILE A CB  1 
ATOM   2809 C  CG1 . ILE A 1 433 ? 160.537 204.771 290.469 1.00 34.66 ? 433 ILE A CG1 1 
ATOM   2810 C  CG2 . ILE A 1 433 ? 158.382 204.896 291.603 1.00 34.66 ? 433 ILE A CG2 1 
ATOM   2811 C  CD1 . ILE A 1 433 ? 159.916 204.596 289.147 1.00 34.66 ? 433 ILE A CD1 1 
ATOM   2812 N  N   . ASP A 1 434 ? 159.106 204.975 294.900 1.00 46.34 ? 434 ASP A N   1 
ATOM   2813 C  CA  . ASP A 1 434 ? 158.360 204.698 296.112 1.00 46.34 ? 434 ASP A CA  1 
ATOM   2814 C  C   . ASP A 1 434 ? 156.932 204.278 295.789 1.00 46.34 ? 434 ASP A C   1 
ATOM   2815 O  O   . ASP A 1 434 ? 156.469 204.369 294.651 1.00 46.34 ? 434 ASP A O   1 
ATOM   2816 C  CB  . ASP A 1 434 ? 158.356 205.925 297.016 1.00 46.34 ? 434 ASP A CB  1 
ATOM   2817 C  CG  . ASP A 1 434 ? 158.107 205.579 298.465 1.00 46.34 ? 434 ASP A CG  1 
ATOM   2818 O  OD1 . ASP A 1 434 ? 157.710 204.426 298.742 1.00 46.34 ? 434 ASP A OD1 1 
ATOM   2819 O  OD2 . ASP A 1 434 ? 158.305 206.460 299.328 1.00 46.34 ? 434 ASP A OD2 1 
ATOM   2820 N  N   . GLU A 1 435 ? 156.233 203.784 296.813 1.00 51.33 ? 435 GLU A N   1 
ATOM   2821 C  CA  . GLU A 1 435 ? 154.826 203.441 296.638 1.00 51.33 ? 435 GLU A CA  1 
ATOM   2822 C  C   . GLU A 1 435 ? 153.995 204.666 296.298 1.00 51.33 ? 435 GLU A C   1 
ATOM   2823 O  O   . GLU A 1 435 ? 152.936 204.543 295.675 1.00 51.33 ? 435 GLU A O   1 
ATOM   2824 C  CB  . GLU A 1 435 ? 154.280 202.774 297.897 1.00 51.33 ? 435 GLU A CB  1 
ATOM   2825 C  CG  . GLU A 1 435 ? 154.790 201.371 298.121 1.00 51.33 ? 435 GLU A CG  1 
ATOM   2826 C  CD  . GLU A 1 435 ? 154.254 200.394 297.100 1.00 51.33 ? 435 GLU A CD  1 
ATOM   2827 O  OE1 . GLU A 1 435 ? 153.101 200.571 296.660 1.00 51.33 ? 435 GLU A OE1 1 
ATOM   2828 O  OE2 . GLU A 1 435 ? 154.986 199.453 296.733 1.00 51.33 ? 435 GLU A OE2 1 
ATOM   2829 N  N   . LYS A 1 436 ? 154.451 205.850 296.704 1.00 48.86 ? 436 LYS A N   1 
ATOM   2830 C  CA  . LYS A 1 436 ? 153.783 207.100 296.389 1.00 48.86 ? 436 LYS A CA  1 
ATOM   2831 C  C   . LYS A 1 436 ? 154.189 207.657 295.034 1.00 48.86 ? 436 LYS A C   1 
ATOM   2832 O  O   . LYS A 1 436 ? 153.980 208.845 294.778 1.00 48.86 ? 436 LYS A O   1 
ATOM   2833 C  CB  . LYS A 1 436 ? 154.056 208.124 297.486 1.00 48.86 ? 436 LYS A CB  1 
ATOM   2834 C  CG  . LYS A 1 436 ? 153.891 207.564 298.879 1.00 48.86 ? 436 LYS A CG  1 
ATOM   2835 C  CD  . LYS A 1 436 ? 154.566 208.445 299.905 1.00 48.86 ? 436 LYS A CD  1 
ATOM   2836 C  CE  . LYS A 1 436 ? 153.692 209.632 300.272 1.00 48.86 ? 436 LYS A CE  1 
ATOM   2837 N  NZ  . LYS A 1 436 ? 153.796 209.976 301.716 1.00 48.86 ? 436 LYS A NZ  1 
ATOM   2838 N  N   . ALA A 1 437 ? 154.769 206.829 294.172 1.00 45.70 ? 437 ALA A N   1 
ATOM   2839 C  CA  . ALA A 1 437 ? 155.141 207.216 292.815 1.00 45.70 ? 437 ALA A CA  1 
ATOM   2840 C  C   . ALA A 1 437 ? 156.116 208.393 292.796 1.00 45.70 ? 437 ALA A C   1 
ATOM   2841 O  O   . ALA A 1 437 ? 155.956 209.339 292.027 1.00 45.70 ? 437 ALA A O   1 
ATOM   2842 C  CB  . ALA A 1 437 ? 153.897 207.523 291.981 1.00 45.70 ? 437 ALA A CB  1 
ATOM   2843 N  N   . ILE A 1 438 ? 157.151 208.317 293.631 1.00 41.86 ? 438 ILE A N   1 
ATOM   2844 C  CA  . ILE A 1 438 ? 158.213 209.320 293.687 1.00 41.86 ? 438 ILE A CA  1 
ATOM   2845 C  C   . ILE A 1 438 ? 159.532 208.652 293.336 1.00 41.86 ? 438 ILE A C   1 
ATOM   2846 O  O   . ILE A 1 438 ? 160.001 207.779 294.072 1.00 41.86 ? 438 ILE A O   1 
ATOM   2847 C  CB  . ILE A 1 438 ? 158.309 209.985 295.065 1.00 41.86 ? 438 ILE A CB  1 
ATOM   2848 C  CG1 . ILE A 1 438 ? 157.085 210.836 295.340 1.00 41.86 ? 438 ILE A CG1 1 
ATOM   2849 C  CG2 . ILE A 1 438 ? 159.523 210.856 295.137 1.00 41.86 ? 438 ILE A CG2 1 
ATOM   2850 C  CD1 . ILE A 1 438 ? 156.728 210.864 296.786 1.00 41.86 ? 438 ILE A CD1 1 
ATOM   2851 N  N   . ILE A 1 439 ? 160.136 209.068 292.238 1.00 36.15 ? 439 ILE A N   1 
ATOM   2852 C  CA  . ILE A 1 439 ? 161.436 208.558 291.835 1.00 36.15 ? 439 ILE A CA  1 
ATOM   2853 C  C   . ILE A 1 439 ? 162.524 209.219 292.659 1.00 36.15 ? 439 ILE A C   1 
ATOM   2854 O  O   . ILE A 1 439 ? 162.486 210.424 292.907 1.00 36.15 ? 439 ILE A O   1 
ATOM   2855 C  CB  . ILE A 1 439 ? 161.664 208.830 290.343 1.00 36.15 ? 439 ILE A CB  1 
ATOM   2856 C  CG1 . ILE A 1 439 ? 160.439 208.430 289.539 1.00 36.15 ? 439 ILE A CG1 1 
ATOM   2857 C  CG2 . ILE A 1 439 ? 162.879 208.098 289.858 1.00 36.15 ? 439 ILE A CG2 1 
ATOM   2858 C  CD1 . ILE A 1 439 ? 160.605 208.628 288.069 1.00 36.15 ? 439 ILE A CD1 1 
ATOM   2859 N  N   . SER A 1 440 ? 163.492 208.428 293.107 1.00 33.15 ? 440 SER A N   1 
ATOM   2860 C  CA  . SER A 1 440 ? 164.621 208.924 293.878 1.00 33.15 ? 440 SER A CA  1 
ATOM   2861 C  C   . SER A 1 440 ? 165.884 208.779 293.046 1.00 33.15 ? 440 SER A C   1 
ATOM   2862 O  O   . SER A 1 440 ? 166.108 207.745 292.419 1.00 33.15 ? 440 SER A O   1 
ATOM   2863 C  CB  . SER A 1 440 ? 164.782 208.173 295.190 1.00 33.15 ? 440 SER A CB  1 
ATOM   2864 O  OG  . SER A 1 440 ? 163.690 208.399 296.048 1.00 33.15 ? 440 SER A OG  1 
ATOM   2865 N  N   . TYR A 1 441 ? 166.701 209.818 293.037 1.00 34.35 ? 441 TYR A N   1 
ATOM   2866 C  CA  . TYR A 1 441 ? 168.002 209.799 292.396 1.00 34.35 ? 441 TYR A CA  1 
ATOM   2867 C  C   . TYR A 1 441 ? 169.060 210.131 293.430 1.00 34.35 ? 441 TYR A C   1 
ATOM   2868 O  O   . TYR A 1 441 ? 168.820 210.932 294.328 1.00 34.35 ? 441 TYR A O   1 
ATOM   2869 C  CB  . TYR A 1 441 ? 168.059 210.801 291.259 1.00 34.35 ? 441 TYR A CB  1 
ATOM   2870 C  CG  . TYR A 1 441 ? 167.391 210.338 289.998 1.00 34.35 ? 441 TYR A CG  1 
ATOM   2871 C  CD1 . TYR A 1 441 ? 168.079 209.587 289.070 1.00 34.35 ? 441 TYR A CD1 1 
ATOM   2872 C  CD2 . TYR A 1 441 ? 166.074 210.652 289.735 1.00 34.35 ? 441 TYR A CD2 1 
ATOM   2873 C  CE1 . TYR A 1 441 ? 167.480 209.164 287.918 1.00 34.35 ? 441 TYR A CE1 1 
ATOM   2874 C  CE2 . TYR A 1 441 ? 165.465 210.228 288.586 1.00 34.35 ? 441 TYR A CE2 1 
ATOM   2875 C  CZ  . TYR A 1 441 ? 166.173 209.481 287.682 1.00 34.35 ? 441 TYR A CZ  1 
ATOM   2876 O  OH  . TYR A 1 441 ? 165.571 209.055 286.524 1.00 34.35 ? 441 TYR A OH  1 
ATOM   2877 N  N   . LEU A 1 442 ? 170.212 209.489 293.334 1.00 32.87 ? 442 LEU A N   1 
ATOM   2878 C  CA  . LEU A 1 442 ? 171.330 209.755 294.223 1.00 32.87 ? 442 LEU A CA  1 
ATOM   2879 C  C   . LEU A 1 442 ? 172.372 210.521 293.429 1.00 32.87 ? 442 LEU A C   1 
ATOM   2880 O  O   . LEU A 1 442 ? 172.924 209.990 292.461 1.00 32.87 ? 442 LEU A O   1 
ATOM   2881 C  CB  . LEU A 1 442 ? 171.917 208.464 294.785 1.00 32.87 ? 442 LEU A CB  1 
ATOM   2882 C  CG  . LEU A 1 442 ? 172.913 208.599 295.926 1.00 32.87 ? 442 LEU A CG  1 
ATOM   2883 C  CD1 . LEU A 1 442 ? 172.233 209.038 297.198 1.00 32.87 ? 442 LEU A CD1 1 
ATOM   2884 C  CD2 . LEU A 1 442 ? 173.592 207.281 296.119 1.00 32.87 ? 442 LEU A CD2 1 
ATOM   2885 N  N   . VAL A 1 443 ? 172.620 211.766 293.822 1.00 33.42 ? 443 VAL A N   1 
ATOM   2886 C  CA  . VAL A 1 443 ? 173.619 212.611 293.184 1.00 33.42 ? 443 VAL A CA  1 
ATOM   2887 C  C   . VAL A 1 443 ? 174.807 212.707 294.125 1.00 33.42 ? 443 VAL A C   1 
ATOM   2888 O  O   . VAL A 1 443 ? 174.667 213.169 295.262 1.00 33.42 ? 443 VAL A O   1 
ATOM   2889 C  CB  . VAL A 1 443 ? 173.053 213.999 292.860 1.00 33.42 ? 443 VAL A CB  1 
ATOM   2890 C  CG1 . VAL A 1 443 ? 173.882 214.669 291.793 1.00 33.42 ? 443 VAL A CG1 1 
ATOM   2891 C  CG2 . VAL A 1 443 ? 171.614 213.887 292.414 1.00 33.42 ? 443 VAL A CG2 1 
ATOM   2892 N  N   . SER A 1 444 ? 175.970 212.257 293.661 1.00 33.22 ? 444 SER A N   1 
ATOM   2893 C  CA  . SER A 1 444 ? 177.162 212.140 294.489 1.00 33.22 ? 444 SER A CA  1 
ATOM   2894 C  C   . SER A 1 444 ? 178.365 212.732 293.783 1.00 33.22 ? 444 SER A C   1 
ATOM   2895 O  O   . SER A 1 444 ? 178.494 212.623 292.561 1.00 33.22 ? 444 SER A O   1 
ATOM   2896 C  CB  . SER A 1 444 ? 177.484 210.693 294.844 1.00 33.22 ? 444 SER A CB  1 
ATOM   2897 O  OG  . SER A 1 444 ? 176.371 210.018 295.382 1.00 33.22 ? 444 SER A OG  1 
ATOM   2898 N  N   . THR A 1 445 ? 179.246 213.352 294.564 1.00 31.64 ? 445 THR A N   1 
ATOM   2899 C  CA  . THR A 1 445 ? 180.546 213.784 294.074 1.00 31.64 ? 445 THR A CA  1 
ATOM   2900 C  C   . THR A 1 445 ? 181.573 213.564 295.172 1.00 31.64 ? 445 THR A C   1 
ATOM   2901 O  O   . THR A 1 445 ? 181.265 213.717 296.353 1.00 31.64 ? 445 THR A O   1 
ATOM   2902 C  CB  . THR A 1 445 ? 180.535 215.247 293.650 1.00 31.64 ? 445 THR A CB  1 
ATOM   2903 O  OG1 . THR A 1 445 ? 181.852 215.634 293.252 1.00 31.64 ? 445 THR A OG1 1 
ATOM   2904 C  CG2 . THR A 1 445 ? 180.086 216.119 294.788 1.00 31.64 ? 445 THR A CG2 1 
ATOM   2905 N  N   . TYR A 1 446 ? 182.789 213.196 294.784 1.00 30.17 ? 446 TYR A N   1 
ATOM   2906 C  CA  . TYR A 1 446 ? 183.866 212.900 295.722 1.00 30.17 ? 446 TYR A CA  1 
ATOM   2907 C  C   . TYR A 1 446 ? 184.990 213.905 295.539 1.00 30.17 ? 446 TYR A C   1 
ATOM   2908 O  O   . TYR A 1 446 ? 185.478 214.096 294.424 1.00 30.17 ? 446 TYR A O   1 
ATOM   2909 C  CB  . TYR A 1 446 ? 184.380 211.476 295.533 1.00 30.17 ? 446 TYR A CB  1 
ATOM   2910 C  CG  . TYR A 1 446 ? 183.309 210.442 295.768 1.00 30.17 ? 446 TYR A CG  1 
ATOM   2911 C  CD1 . TYR A 1 446 ? 183.075 209.937 297.028 1.00 30.17 ? 446 TYR A CD1 1 
ATOM   2912 C  CD2 . TYR A 1 446 ? 182.525 209.984 294.727 1.00 30.17 ? 446 TYR A CD2 1 
ATOM   2913 C  CE1 . TYR A 1 446 ? 182.095 209.014 297.242 1.00 30.17 ? 446 TYR A CE1 1 
ATOM   2914 C  CE2 . TYR A 1 446 ? 181.544 209.059 294.936 1.00 30.17 ? 446 TYR A CE2 1 
ATOM   2915 C  CZ  . TYR A 1 446 ? 181.334 208.577 296.193 1.00 30.17 ? 446 TYR A CZ  1 
ATOM   2916 O  OH  . TYR A 1 446 ? 180.353 207.651 296.407 1.00 30.17 ? 446 TYR A OH  1 
ATOM   2917 N  N   . TYR A 1 447 ? 185.406 214.530 296.637 1.00 28.27 ? 447 TYR A N   1 
ATOM   2918 C  CA  . TYR A 1 447 ? 186.362 215.625 296.600 1.00 28.27 ? 447 TYR A CA  1 
ATOM   2919 C  C   . TYR A 1 447 ? 187.122 215.685 297.913 1.00 28.27 ? 447 TYR A C   1 
ATOM   2920 O  O   . TYR A 1 447 ? 186.668 215.185 298.940 1.00 28.27 ? 447 TYR A O   1 
ATOM   2921 C  CB  . TYR A 1 447 ? 185.670 216.969 296.370 1.00 28.27 ? 447 TYR A CB  1 
ATOM   2922 C  CG  . TYR A 1 447 ? 184.818 217.377 297.541 1.00 28.27 ? 447 TYR A CG  1 
ATOM   2923 C  CD1 . TYR A 1 447 ? 183.571 216.845 297.718 1.00 28.27 ? 447 TYR A CD1 1 
ATOM   2924 C  CD2 . TYR A 1 447 ? 185.273 218.278 298.478 1.00 28.27 ? 447 TYR A CD2 1 
ATOM   2925 C  CE1 . TYR A 1 447 ? 182.803 217.196 298.777 1.00 28.27 ? 447 TYR A CE1 1 
ATOM   2926 C  CE2 . TYR A 1 447 ? 184.505 218.629 299.547 1.00 28.27 ? 447 TYR A CE2 1 
ATOM   2927 C  CZ  . TYR A 1 447 ? 183.270 218.081 299.691 1.00 28.27 ? 447 TYR A CZ  1 
ATOM   2928 O  OH  . TYR A 1 447 ? 182.477 218.422 300.754 1.00 28.27 ? 447 TYR A OH  1 
ATOM   2929 N  N   . SER A 1 448 ? 188.293 216.307 297.861 1.00 28.20 ? 448 SER A N   1 
ATOM   2930 C  CA  . SER A 1 448 ? 189.096 216.602 299.039 1.00 28.20 ? 448 SER A CA  1 
ATOM   2931 C  C   . SER A 1 448 ? 190.162 217.599 298.608 1.00 28.20 ? 448 SER A C   1 
ATOM   2932 O  O   . SER A 1 448 ? 190.304 217.903 297.426 1.00 28.20 ? 448 SER A O   1 
ATOM   2933 C  CB  . SER A 1 448 ? 189.710 215.349 299.650 1.00 28.20 ? 448 SER A CB  1 
ATOM   2934 O  OG  . SER A 1 448 ? 190.200 215.615 300.946 1.00 28.20 ? 448 SER A OG  1 
ATOM   2935 N  N   . ALA A 1 449 ? 190.904 218.109 299.579 1.00 28.09 ? 449 ALA A N   1 
ATOM   2936 C  CA  . ALA A 1 449 ? 191.976 219.066 299.352 1.00 28.09 ? 449 ALA A CA  1 
ATOM   2937 C  C   . ALA A 1 449 ? 193.253 218.594 300.020 1.00 28.09 ? 449 ALA A C   1 
ATOM   2938 O  O   . ALA A 1 449 ? 193.219 218.068 301.132 1.00 28.09 ? 449 ALA A O   1 
ATOM   2939 C  CB  . ALA A 1 449 ? 191.608 220.448 299.881 1.00 28.09 ? 449 ALA A CB  1 
ATOM   2940 N  N   . ALA A 1 450 ? 194.378 218.805 299.352 1.00 28.66 ? 450 ALA A N   1 
ATOM   2941 C  CA  . ALA A 1 450 ? 195.682 218.443 299.882 1.00 28.66 ? 450 ALA A CA  1 
ATOM   2942 C  C   . ALA A 1 450 ? 196.612 219.638 299.813 1.00 28.66 ? 450 ALA A C   1 
ATOM   2943 O  O   . ALA A 1 450 ? 196.572 220.407 298.854 1.00 28.66 ? 450 ALA A O   1 
ATOM   2944 C  CB  . ALA A 1 450 ? 196.299 217.292 299.107 1.00 28.66 ? 450 ALA A CB  1 
ATOM   2945 N  N   . ILE A 1 451 ? 197.427 219.808 300.846 1.00 28.25 ? 451 ILE A N   1 
ATOM   2946 C  CA  . ILE A 1 451 ? 198.441 220.852 300.896 1.00 28.25 ? 451 ILE A CA  1 
ATOM   2947 C  C   . ILE A 1 451 ? 199.775 220.135 300.958 1.00 28.25 ? 451 ILE A C   1 
ATOM   2948 O  O   . ILE A 1 451 ? 200.139 219.576 301.998 1.00 28.25 ? 451 ILE A O   1 
ATOM   2949 C  CB  . ILE A 1 451 ? 198.262 221.777 302.102 1.00 28.25 ? 451 ILE A CB  1 
ATOM   2950 C  CG1 . ILE A 1 451 ? 196.879 222.408 302.080 1.00 28.25 ? 451 ILE A CG1 1 
ATOM   2951 C  CG2 . ILE A 1 451 ? 199.310 222.853 302.093 1.00 28.25 ? 451 ILE A CG2 1 
ATOM   2952 C  CD1 . ILE A 1 451 ? 196.691 223.458 303.098 1.00 28.25 ? 451 ILE A CD1 1 
ATOM   2953 N  N   . LEU A 1 452 ? 200.516 220.171 299.855 1.00 29.36 ? 452 LEU A N   1 
ATOM   2954 C  CA  . LEU A 1 452 ? 201.708 219.342 299.728 1.00 29.36 ? 452 LEU A CA  1 
ATOM   2955 C  C   . LEU A 1 452 ? 202.797 219.740 300.718 1.00 29.36 ? 452 LEU A C   1 
ATOM   2956 O  O   . LEU A 1 452 ? 203.430 218.871 301.325 1.00 29.36 ? 452 LEU A O   1 
ATOM   2957 C  CB  . LEU A 1 452 ? 202.211 219.405 298.294 1.00 29.36 ? 452 LEU A CB  1 
ATOM   2958 C  CG  . LEU A 1 452 ? 201.160 219.053 297.240 1.00 29.36 ? 452 LEU A CG  1 
ATOM   2959 C  CD1 . LEU A 1 452 ? 201.795 218.951 295.876 1.00 29.36 ? 452 LEU A CD1 1 
ATOM   2960 C  CD2 . LEU A 1 452 ? 200.489 217.755 297.582 1.00 29.36 ? 452 LEU A CD2 1 
ATOM   2961 N  N   . VAL A 1 453 ? 203.033 221.034 300.902 1.00 28.71 ? 453 VAL A N   1 
ATOM   2962 C  CA  . VAL A 1 453 ? 204.062 221.514 301.822 1.00 28.71 ? 453 VAL A CA  1 
ATOM   2963 C  C   . VAL A 1 453 ? 203.414 222.492 302.790 1.00 28.71 ? 453 VAL A C   1 
ATOM   2964 O  O   . VAL A 1 453 ? 202.445 223.164 302.420 1.00 28.71 ? 453 VAL A O   1 
ATOM   2965 C  CB  . VAL A 1 453 ? 205.224 222.170 301.074 1.00 28.71 ? 453 VAL A CB  1 
ATOM   2966 C  CG1 . VAL A 1 453 ? 206.082 221.126 300.419 1.00 28.71 ? 453 VAL A CG1 1 
ATOM   2967 C  CG2 . VAL A 1 453 ? 204.686 223.118 300.051 1.00 28.71 ? 453 VAL A CG2 1 
ATOM   2968 N  N   . PRO A 1 454 ? 203.918 222.625 304.017 1.00 26.58 ? 454 PRO A N   1 
ATOM   2969 C  CA  . PRO A 1 454 ? 203.268 223.523 304.977 1.00 26.58 ? 454 PRO A CA  1 
ATOM   2970 C  C   . PRO A 1 454 ? 203.186 224.966 304.524 1.00 26.58 ? 454 PRO A C   1 
ATOM   2971 O  O   . PRO A 1 454 ? 202.203 225.645 304.838 1.00 26.58 ? 454 PRO A O   1 
ATOM   2972 C  CB  . PRO A 1 454 ? 204.156 223.391 306.216 1.00 26.58 ? 454 PRO A CB  1 
ATOM   2973 C  CG  . PRO A 1 454 ? 204.846 222.117 306.059 1.00 26.58 ? 454 PRO A CG  1 
ATOM   2974 C  CD  . PRO A 1 454 ? 205.067 221.937 304.611 1.00 26.58 ? 454 PRO A CD  1 
ATOM   2975 N  N   . ASP A 1 455 ? 204.179 225.457 303.793 1.00 27.63 ? 455 ASP A N   1 
ATOM   2976 C  CA  . ASP A 1 455 ? 204.244 226.860 303.397 1.00 27.63 ? 455 ASP A CA  1 
ATOM   2977 C  C   . ASP A 1 455 ? 203.554 227.120 302.078 1.00 27.63 ? 455 ASP A C   1 
ATOM   2978 O  O   . ASP A 1 455 ? 204.029 227.890 301.253 1.00 27.63 ? 455 ASP A O   1 
ATOM   2979 C  CB  . ASP A 1 455 ? 205.705 227.298 303.363 1.00 27.63 ? 455 ASP A CB  1 
ATOM   2980 C  CG  . ASP A 1 455 ? 206.478 226.717 302.194 1.00 27.63 ? 455 ASP A CG  1 
ATOM   2981 O  OD1 . ASP A 1 455 ? 206.489 227.326 301.104 1.00 27.63 ? 455 ASP A OD1 1 
ATOM   2982 O  OD2 . ASP A 1 455 ? 207.085 225.636 302.370 1.00 27.63 ? 455 ASP A OD2 1 
ATOM   2983 N  N   . ALA A 1 456 ? 202.370 226.555 301.892 1.00 24.63 ? 456 ALA A N   1 
ATOM   2984 C  CA  . ALA A 1 456 ? 201.592 226.753 300.685 1.00 24.63 ? 456 ALA A CA  1 
ATOM   2985 C  C   . ALA A 1 456 ? 200.306 227.514 300.914 1.00 24.63 ? 456 ALA A C   1 
ATOM   2986 O  O   . ALA A 1 456 ? 199.766 228.066 299.959 1.00 24.63 ? 456 ALA A O   1 
ATOM   2987 C  CB  . ALA A 1 456 ? 201.259 225.407 300.035 1.00 24.63 ? 456 ALA A CB  1 
ATOM   2988 N  N   . VAL A 1 457 ? 199.785 227.525 302.136 1.00 22.88 ? 457 VAL A N   1 
ATOM   2989 C  CA  . VAL A 1 457 ? 198.613 228.308 302.490 1.00 22.88 ? 457 VAL A CA  1 
ATOM   2990 C  C   . VAL A 1 457 ? 198.964 229.120 303.721 1.00 22.88 ? 457 VAL A C   1 
ATOM   2991 O  O   . VAL A 1 457 ? 199.339 228.558 304.753 1.00 22.88 ? 457 VAL A O   1 
ATOM   2992 C  CB  . VAL A 1 457 ? 197.389 227.420 302.761 1.00 22.88 ? 457 VAL A CB  1 
ATOM   2993 C  CG1 . VAL A 1 457 ? 196.333 228.169 303.533 1.00 22.88 ? 457 VAL A CG1 1 
ATOM   2994 C  CG2 . VAL A 1 457 ? 196.819 226.931 301.482 1.00 22.88 ? 457 VAL A CG2 1 
ATOM   2995 N  N   . GLY A 1 458 ? 198.853 230.435 303.609 1.00 21.97 ? 458 GLY A N   1 
ATOM   2996 C  CA  . GLY A 1 458 ? 199.021 231.343 304.728 1.00 21.97 ? 458 GLY A CA  1 
ATOM   2997 C  C   . GLY A 1 458 ? 197.706 232.030 305.036 1.00 21.97 ? 458 GLY A C   1 
ATOM   2998 O  O   . GLY A 1 458 ? 196.924 232.303 304.132 1.00 21.97 ? 458 GLY A O   1 
ATOM   2999 N  N   . VAL A 1 459 ? 197.447 232.251 306.316 1.00 23.42 ? 459 VAL A N   1 
ATOM   3000 C  CA  . VAL A 1 459 ? 196.192 232.828 306.773 1.00 23.42 ? 459 VAL A CA  1 
ATOM   3001 C  C   . VAL A 1 459 ? 196.502 234.056 307.615 1.00 23.42 ? 459 VAL A C   1 
ATOM   3002 O  O   . VAL A 1 459 ? 197.284 233.981 308.564 1.00 23.42 ? 459 VAL A O   1 
ATOM   3003 C  CB  . VAL A 1 459 ? 195.363 231.807 307.570 1.00 23.42 ? 459 VAL A CB  1 
ATOM   3004 C  CG1 . VAL A 1 459 ? 194.130 232.440 308.129 1.00 23.42 ? 459 VAL A CG1 1 
ATOM   3005 C  CG2 . VAL A 1 459 ? 194.979 230.657 306.685 1.00 23.42 ? 459 VAL A CG2 1 
ATOM   3006 N  N   . LEU A 1 460 ? 195.911 235.187 307.251 1.00 24.43 ? 460 LEU A N   1 
ATOM   3007 C  CA  . LEU A 1 460 ? 195.959 236.414 308.033 1.00 24.43 ? 460 LEU A CA  1 
ATOM   3008 C  C   . LEU A 1 460 ? 194.666 236.500 308.827 1.00 24.43 ? 460 LEU A C   1 
ATOM   3009 O  O   . LEU A 1 460 ? 193.583 236.557 308.241 1.00 24.43 ? 460 LEU A O   1 
ATOM   3010 C  CB  . LEU A 1 460 ? 196.123 237.628 307.124 1.00 24.43 ? 460 LEU A CB  1 
ATOM   3011 C  CG  . LEU A 1 460 ? 196.452 238.990 307.718 1.00 24.43 ? 460 LEU A CG  1 
ATOM   3012 C  CD1 . LEU A 1 460 ? 197.851 239.035 308.256 1.00 24.43 ? 460 LEU A CD1 1 
ATOM   3013 C  CD2 . LEU A 1 460 ? 196.256 240.033 306.662 1.00 24.43 ? 460 LEU A CD2 1 
ATOM   3014 N  N   . GLU A 1 461 ? 194.776 236.507 310.146 1.00 29.13 ? 461 GLU A N   1 
ATOM   3015 C  CA  . GLU A 1 461 ? 193.635 236.339 311.026 1.00 29.13 ? 461 GLU A CA  1 
ATOM   3016 C  C   . GLU A 1 461 ? 193.279 237.623 311.760 1.00 29.13 ? 461 GLU A C   1 
ATOM   3017 O  O   . GLU A 1 461 ? 194.077 238.555 311.851 1.00 29.13 ? 461 GLU A O   1 
ATOM   3018 C  CB  . GLU A 1 461 ? 193.913 235.238 312.040 1.00 29.13 ? 461 GLU A CB  1 
ATOM   3019 C  CG  . GLU A 1 461 ? 193.935 233.867 311.447 1.00 29.13 ? 461 GLU A CG  1 
ATOM   3020 C  CD  . GLU A 1 461 ? 194.330 232.834 312.452 1.00 29.13 ? 461 GLU A CD  1 
ATOM   3021 O  OE1 . GLU A 1 461 ? 194.869 233.206 313.509 1.00 29.13 ? 461 GLU A OE1 1 
ATOM   3022 O  OE2 . GLU A 1 461 ? 194.060 231.648 312.208 1.00 29.13 ? 461 GLU A OE2 1 
ATOM   3023 N  N   . ASN A 1 462 ? 192.065 237.638 312.314 1.00 32.26 ? 462 ASN A N   1 
ATOM   3024 C  CA  . ASN A 1 462 ? 191.560 238.760 313.105 1.00 32.26 ? 462 ASN A CA  1 
ATOM   3025 C  C   . ASN A 1 462 ? 191.617 240.070 312.332 1.00 32.26 ? 462 ASN A C   1 
ATOM   3026 O  O   . ASN A 1 462 ? 192.010 241.109 312.861 1.00 32.26 ? 462 ASN A O   1 
ATOM   3027 C  CB  . ASN A 1 462 ? 192.309 238.887 314.424 1.00 32.26 ? 462 ASN A CB  1 
ATOM   3028 C  CG  . ASN A 1 462 ? 192.664 237.556 315.011 1.00 32.26 ? 462 ASN A CG  1 
ATOM   3029 O  OD1 . ASN A 1 462 ? 191.928 236.587 314.866 1.00 32.26 ? 462 ASN A OD1 1 
ATOM   3030 N  ND2 . ASN A 1 462 ? 193.805 237.495 315.680 1.00 32.26 ? 462 ASN A ND2 1 
ATOM   3031 N  N   . VAL A 1 463 ? 191.199 240.022 311.074 1.00 31.48 ? 463 VAL A N   1 
ATOM   3032 C  CA  . VAL A 1 463 ? 191.189 241.186 310.199 1.00 31.48 ? 463 VAL A CA  1 
ATOM   3033 C  C   . VAL A 1 463 ? 189.906 241.969 310.450 1.00 31.48 ? 463 VAL A C   1 
ATOM   3034 O  O   . VAL A 1 463 ? 188.815 241.505 310.123 1.00 31.48 ? 463 VAL A O   1 
ATOM   3035 C  CB  . VAL A 1 463 ? 191.304 240.768 308.732 1.00 31.48 ? 463 VAL A CB  1 
ATOM   3036 C  CG1 . VAL A 1 463 ? 191.064 241.932 307.840 1.00 31.48 ? 463 VAL A CG1 1 
ATOM   3037 C  CG2 . VAL A 1 463 ? 192.660 240.204 308.463 1.00 31.48 ? 463 VAL A CG2 1 
ATOM   3038 N  N   . GLN A 1 464 ? 190.031 243.162 311.019 1.00 34.86 ? 464 GLN A N   1 
ATOM   3039 C  CA  . GLN A 1 464 ? 188.867 244.000 311.277 1.00 34.86 ? 464 GLN A CA  1 
ATOM   3040 C  C   . GLN A 1 464 ? 188.352 244.581 309.971 1.00 34.86 ? 464 GLN A C   1 
ATOM   3041 O  O   . GLN A 1 464 ? 189.048 245.351 309.306 1.00 34.86 ? 464 GLN A O   1 
ATOM   3042 C  CB  . GLN A 1 464 ? 189.223 245.116 312.246 1.00 34.86 ? 464 GLN A CB  1 
ATOM   3043 C  CG  . GLN A 1 464 ? 189.313 244.675 313.678 1.00 34.86 ? 464 GLN A CG  1 
ATOM   3044 C  CD  . GLN A 1 464 ? 189.988 245.706 314.549 1.00 34.86 ? 464 GLN A CD  1 
ATOM   3045 O  OE1 . GLN A 1 464 ? 190.195 246.842 314.133 1.00 34.86 ? 464 GLN A OE1 1 
ATOM   3046 N  NE2 . GLN A 1 464 ? 190.342 245.315 315.763 1.00 34.86 ? 464 GLN A NE2 1 
ATOM   3047 N  N   . ILE A 1 465 ? 187.119 244.235 309.615 1.00 31.68 ? 465 ILE A N   1 
ATOM   3048 C  CA  . ILE A 1 465 ? 186.542 244.606 308.331 1.00 31.68 ? 465 ILE A CA  1 
ATOM   3049 C  C   . ILE A 1 465 ? 185.455 245.658 308.450 1.00 31.68 ? 465 ILE A C   1 
ATOM   3050 O  O   . ILE A 1 465 ? 184.812 245.978 307.443 1.00 31.68 ? 465 ILE A O   1 
ATOM   3051 C  CB  . ILE A 1 465 ? 186.001 243.371 307.596 1.00 31.68 ? 465 ILE A CB  1 
ATOM   3052 C  CG1 . ILE A 1 465 ? 184.788 242.830 308.328 1.00 31.68 ? 465 ILE A CG1 1 
ATOM   3053 C  CG2 . ILE A 1 465 ? 187.063 242.306 307.505 1.00 31.68 ? 465 ILE A CG2 1 
ATOM   3054 C  CD1 . ILE A 1 465 ? 184.110 241.763 307.583 1.00 31.68 ? 465 ILE A CD1 1 
ATOM   3055 N  N   . ALA A 1 466 ? 185.206 246.187 309.637 1.00 37.35 ? 466 ALA A N   1 
ATOM   3056 C  CA  . ALA A 1 466 ? 184.189 247.207 309.846 1.00 37.35 ? 466 ALA A CA  1 
ATOM   3057 C  C   . ALA A 1 466 ? 184.818 248.511 310.310 1.00 37.35 ? 466 ALA A C   1 
ATOM   3058 O  O   . ALA A 1 466 ? 184.275 249.218 311.157 1.00 37.35 ? 466 ALA A O   1 
ATOM   3059 C  CB  . ALA A 1 466 ? 183.135 246.735 310.839 1.00 37.35 ? 466 ALA A CB  1 
ATOM   3060 N  N   . ASN A 1 467 ? 185.978 248.841 309.759 1.00 39.85 ? 467 ASN A N   1 
ATOM   3061 C  CA  . ASN A 1 467 ? 186.704 250.049 310.115 1.00 39.85 ? 467 ASN A CA  1 
ATOM   3062 C  C   . ASN A 1 467 ? 186.547 251.077 309.006 1.00 39.85 ? 467 ASN A C   1 
ATOM   3063 O  O   . ASN A 1 467 ? 186.750 250.761 307.831 1.00 39.85 ? 467 ASN A O   1 
ATOM   3064 C  CB  . ASN A 1 467 ? 188.183 249.739 310.334 1.00 39.85 ? 467 ASN A CB  1 
ATOM   3065 C  CG  . ASN A 1 467 ? 188.487 249.347 311.757 1.00 39.85 ? 467 ASN A CG  1 
ATOM   3066 O  OD1 . ASN A 1 467 ? 187.586 249.226 312.581 1.00 39.85 ? 467 ASN A OD1 1 
ATOM   3067 N  ND2 . ASN A 1 467 ? 189.760 249.141 312.057 1.00 39.85 ? 467 ASN A ND2 1 
ATOM   3068 N  N   . TRP A 1 468 ? 186.171 252.295 309.380 1.00 40.33 ? 468 TRP A N   1 
ATOM   3069 C  CA  . TRP A 1 468 ? 185.965 253.387 308.445 1.00 40.33 ? 468 TRP A CA  1 
ATOM   3070 C  C   . TRP A 1 468 ? 186.762 254.603 308.888 1.00 40.33 ? 468 TRP A C   1 
ATOM   3071 O  O   . TRP A 1 468 ? 187.039 254.764 310.080 1.00 40.33 ? 468 TRP A O   1 
ATOM   3072 C  CB  . TRP A 1 468 ? 184.482 253.761 308.351 1.00 40.33 ? 468 TRP A CB  1 
ATOM   3073 C  CG  . TRP A 1 468 ? 183.686 252.878 307.465 1.00 40.33 ? 468 TRP A CG  1 
ATOM   3074 C  CD1 . TRP A 1 468 ? 183.125 251.687 307.795 1.00 40.33 ? 468 TRP A CD1 1 
ATOM   3075 C  CD2 . TRP A 1 468 ? 183.348 253.113 306.098 1.00 40.33 ? 468 TRP A CD2 1 
ATOM   3076 N  NE1 . TRP A 1 468 ? 182.461 251.162 306.720 1.00 40.33 ? 468 TRP A NE1 1 
ATOM   3077 C  CE2 . TRP A 1 468 ? 182.583 252.023 305.663 1.00 40.33 ? 468 TRP A CE2 1 
ATOM   3078 C  CE3 . TRP A 1 468 ? 183.620 254.141 305.197 1.00 40.33 ? 468 TRP A CE3 1 
ATOM   3079 C  CZ2 . TRP A 1 468 ? 182.084 251.931 304.371 1.00 40.33 ? 468 TRP A CZ2 1 
ATOM   3080 C  CZ3 . TRP A 1 468 ? 183.122 254.046 303.918 1.00 40.33 ? 468 TRP A CZ3 1 
ATOM   3081 C  CH2 . TRP A 1 468 ? 182.368 252.952 303.516 1.00 40.33 ? 468 TRP A CH2 1 
ATOM   3082 N  N   . PRO A 1 469 ? 187.157 255.466 307.951 1.00 48.68 ? 469 PRO A N   1 
ATOM   3083 C  CA  . PRO A 1 469 ? 187.901 256.671 308.334 1.00 48.68 ? 469 PRO A CA  1 
ATOM   3084 C  C   . PRO A 1 469 ? 187.093 257.565 309.260 1.00 48.68 ? 469 PRO A C   1 
ATOM   3085 O  O   . PRO A 1 469 ? 185.886 257.741 309.091 1.00 48.68 ? 469 PRO A O   1 
ATOM   3086 C  CB  . PRO A 1 469 ? 188.177 257.360 306.993 1.00 48.68 ? 469 PRO A CB  1 
ATOM   3087 C  CG  . PRO A 1 469 ? 187.224 256.756 306.040 1.00 48.68 ? 469 PRO A CG  1 
ATOM   3088 C  CD  . PRO A 1 469 ? 187.014 255.357 306.493 1.00 48.68 ? 469 PRO A CD  1 
ATOM   3089 N  N   . ARG A 1 470 ? 187.782 258.154 310.229 1.00 58.97 ? 470 ARG A N   1 
ATOM   3090 C  CA  . ARG A 1 470 ? 187.138 259.019 311.204 1.00 58.97 ? 470 ARG A CA  1 
ATOM   3091 C  C   . ARG A 1 470 ? 187.952 260.288 311.404 1.00 58.97 ? 470 ARG A C   1 
ATOM   3092 O  O   . ARG A 1 470 ? 189.059 260.239 311.940 1.00 58.97 ? 470 ARG A O   1 
ATOM   3093 C  CB  . ARG A 1 470 ? 186.969 258.293 312.540 1.00 58.97 ? 470 ARG A CB  1 
ATOM   3094 C  CG  . ARG A 1 470 ? 185.699 257.470 312.648 1.00 58.97 ? 470 ARG A CG  1 
ATOM   3095 C  CD  . ARG A 1 470 ? 184.505 258.212 312.083 1.00 58.97 ? 470 ARG A CD  1 
ATOM   3096 N  NE  . ARG A 1 470 ? 183.263 257.485 312.317 1.00 58.97 ? 470 ARG A NE  1 
ATOM   3097 C  CZ  . ARG A 1 470 ? 182.860 256.438 311.610 1.00 58.97 ? 470 ARG A CZ  1 
ATOM   3098 N  NH1 . ARG A 1 470 ? 183.574 255.966 310.602 1.00 58.97 ? 470 ARG A NH1 1 
ATOM   3099 N  NH2 . ARG A 1 470 ? 181.710 255.849 311.923 1.00 58.97 ? 470 ARG A NH2 1 
HETATM 3100 CA CA  . CA  B 2 .   ? 212.049 222.134 320.210 1.00 30.00 ? 501 CA  A CA  1 
# 
