data_9BFR
# 
_entry.id   9BFR 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BFR         pdb_00009bfr 10.2210/pdb9bfr/pdb 
WWPDB D_1000282978 ?            ?                   
EMDB  EMD-44504    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1  'Structure model' 1 0 2025-01-29 ? 
2  'EM metadata'     1 0 2025-01-29 ? 
3  'Additional map'  1 0 2025-01-29 1 
4  'Additional map'  1 0 2025-01-29 2 
5  'Additional map'  1 0 2025-01-29 3 
6  'Half map'        1 0 2025-01-29 1 
7  'Half map'        1 0 2025-01-29 2 
8  Image             1 0 2025-01-29 ? 
9  'Primary map'     1 0 2025-01-29 ? 
10 'Structure model' 1 1 2025-05-14 ? 
11 'EM metadata'     1 1 2025-05-14 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 'Additional map'  repository 'Initial release' ? ? 
4 4 'Additional map'  repository 'Initial release' ? ? 
5 5 'Additional map'  repository 'Initial release' ? ? 
6 6 'Half map'        repository 'Initial release' ? ? 
7 7 'Half map'        repository 'Initial release' ? ? 
8 8 Image             repository 'Initial release' ? ? 
9 9 'Primary map'     repository 'Initial release' ? ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 10 'Structure model' 'Data collection'      
2 11 'EM metadata'     'Data processing'      
3 11 'EM metadata'     'Experimental summary' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 10 'Structure model' em_admin    
2 10 'Structure model' em_software 
3 11 'EM metadata'     em_admin    
4 11 'EM metadata'     em_software 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 10 'Structure model' '_em_admin.last_update' 
2 10 'Structure model' '_em_software.name'     
3 11 'EM metadata'     '_em_admin.last_update' 
4 11 'EM metadata'     '_em_software.name'     
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BFR 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-18 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB  'Sevenless monomer'                                                                          9BFP      unspecified            
PDB  'Sevenless dimer at pH 6.6'                                                                  9BFS      unspecified            
PDB  'Sevenless dimer at pH 4.6'                                                                  9BFU      unspecified            
PDB  'Sevenless in complex with Boss'                                                             9BFQ      unspecified            
EMDB 'Cryo-EM structure of Bride of Sevenless extracellular domain (dimer, Sevenless-bound form)' EMD-44504 'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              lss8@columbia.edu 
_pdbx_contact_author.name_first         Lawrence 
_pdbx_contact_author.name_last          Shapiro 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-9943-8819 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Cerutti, G.' 1 0000-0002-9081-7561 
'Shapiro, L.' 2 0000-0001-9943-8819 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Mol.Cell 
_citation.journal_id_ASTM           MOCEFL 
_citation.journal_id_CSD            2168 
_citation.journal_id_ISSN           1097-2765 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            84 
_citation.language                  ? 
_citation.page_first                4677 
_citation.page_last                 4690.e6 
_citation.title                     'Structures and pH-dependent dimerization of the sevenless receptor tyrosine kinase.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.molcel.2024.10.017 
_citation.pdbx_database_id_PubMed   39510067 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Cerutti, G.'    1  ? 
primary 'Arias, R.'      2  ? 
primary 'Bahna, F.'      3  ? 
primary 'Mannepalli, S.' 4  ? 
primary 'Katsamba, P.S.' 5  ? 
primary 'Ahlsen, G.'     6  ? 
primary 'Kloss, B.'      7  ? 
primary 'Bruni, R.'      8  ? 
primary 'Tomlinson, A.'  9  ? 
primary 'Shapiro, L.'    10 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Protein bride of sevenless'             57278.723 2 ? ? ? ? 
2 non-polymer syn 2-acetamido-2-deoxy-beta-D-glucopyranose 221.208   6 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;CHGADLTSPTKKSAPLRITKPQPTSQQAKPISITTRAPTTVASTTDDEVSSSVDGQLAPLISSTTEGPSSGTTASLVPEI
CLNGLQLTVNSADEGTVIRKQEEFVKILEGDVVLSVLTKDPDSALFVINRVNQANLIMADFEIGIRAISIDNASLAENLL
IQEVQFLQQCTTYSMGIFVDWELYKQLESVIKDLEYNIWPIPGTRAHLFPKVAHLLHQMPWGEKIASVEIATETLEMYNE
FMEAARQEHMCLMHFKSDDNVYIMFGNKLASHFKENGTLFSVPTDRTDDEFLADLPNRAFVLMENEIDLSTAVELDATPT
ALDEILIGKSVLPSRVLSFAGSIIDLMNWLRGSLSKHCKRGEEHDLYVLESCFNFLNFIEDWRTSEYRQAHDTAEILSLL
LMRKLGTAMNFQMYQKKVLTLDKITGESRTELREIASQNFVTNVTTYYHYNRDNHTSLELKTKFGQVFNCQYSAGDNRRY
PFLFDGESVMFWRIKMDTWHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;CHGADLTSPTKKSAPLRITKPQPTSQQAKPISITTRAPTTVASTTDDEVSSSVDGQLAPLISSTTEGPSSGTTASLVPEI
CLNGLQLTVNSADEGTVIRKQEEFVKILEGDVVLSVLTKDPDSALFVINRVNQANLIMADFEIGIRAISIDNASLAENLL
IQEVQFLQQCTTYSMGIFVDWELYKQLESVIKDLEYNIWPIPGTRAHLFPKVAHLLHQMPWGEKIASVEIATETLEMYNE
FMEAARQEHMCLMHFKSDDNVYIMFGNKLASHFKENGTLFSVPTDRTDDEFLADLPNRAFVLMENEIDLSTAVELDATPT
ALDEILIGKSVLPSRVLSFAGSIIDLMNWLRGSLSKHCKRGEEHDLYVLESCFNFLNFIEDWRTSEYRQAHDTAEILSLL
LMRKLGTAMNFQMYQKKVLTLDKITGESRTELREIASQNFVTNVTTYYHYNRDNHTSLELKTKFGQVFNCQYSAGDNRRY
PFLFDGESVMFWRIKMDTWHHHHHH
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        2-acetamido-2-deoxy-beta-D-glucopyranose 
_pdbx_entity_nonpoly.comp_id     NAG 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   CYS n 
1 2   HIS n 
1 3   GLY n 
1 4   ALA n 
1 5   ASP n 
1 6   LEU n 
1 7   THR n 
1 8   SER n 
1 9   PRO n 
1 10  THR n 
1 11  LYS n 
1 12  LYS n 
1 13  SER n 
1 14  ALA n 
1 15  PRO n 
1 16  LEU n 
1 17  ARG n 
1 18  ILE n 
1 19  THR n 
1 20  LYS n 
1 21  PRO n 
1 22  GLN n 
1 23  PRO n 
1 24  THR n 
1 25  SER n 
1 26  GLN n 
1 27  GLN n 
1 28  ALA n 
1 29  LYS n 
1 30  PRO n 
1 31  ILE n 
1 32  SER n 
1 33  ILE n 
1 34  THR n 
1 35  THR n 
1 36  ARG n 
1 37  ALA n 
1 38  PRO n 
1 39  THR n 
1 40  THR n 
1 41  VAL n 
1 42  ALA n 
1 43  SER n 
1 44  THR n 
1 45  THR n 
1 46  ASP n 
1 47  ASP n 
1 48  GLU n 
1 49  VAL n 
1 50  SER n 
1 51  SER n 
1 52  SER n 
1 53  VAL n 
1 54  ASP n 
1 55  GLY n 
1 56  GLN n 
1 57  LEU n 
1 58  ALA n 
1 59  PRO n 
1 60  LEU n 
1 61  ILE n 
1 62  SER n 
1 63  SER n 
1 64  THR n 
1 65  THR n 
1 66  GLU n 
1 67  GLY n 
1 68  PRO n 
1 69  SER n 
1 70  SER n 
1 71  GLY n 
1 72  THR n 
1 73  THR n 
1 74  ALA n 
1 75  SER n 
1 76  LEU n 
1 77  VAL n 
1 78  PRO n 
1 79  GLU n 
1 80  ILE n 
1 81  CYS n 
1 82  LEU n 
1 83  ASN n 
1 84  GLY n 
1 85  LEU n 
1 86  GLN n 
1 87  LEU n 
1 88  THR n 
1 89  VAL n 
1 90  ASN n 
1 91  SER n 
1 92  ALA n 
1 93  ASP n 
1 94  GLU n 
1 95  GLY n 
1 96  THR n 
1 97  VAL n 
1 98  ILE n 
1 99  ARG n 
1 100 LYS n 
1 101 GLN n 
1 102 GLU n 
1 103 GLU n 
1 104 PHE n 
1 105 VAL n 
1 106 LYS n 
1 107 ILE n 
1 108 LEU n 
1 109 GLU n 
1 110 GLY n 
1 111 ASP n 
1 112 VAL n 
1 113 VAL n 
1 114 LEU n 
1 115 SER n 
1 116 VAL n 
1 117 LEU n 
1 118 THR n 
1 119 LYS n 
1 120 ASP n 
1 121 PRO n 
1 122 ASP n 
1 123 SER n 
1 124 ALA n 
1 125 LEU n 
1 126 PHE n 
1 127 VAL n 
1 128 ILE n 
1 129 ASN n 
1 130 ARG n 
1 131 VAL n 
1 132 ASN n 
1 133 GLN n 
1 134 ALA n 
1 135 ASN n 
1 136 LEU n 
1 137 ILE n 
1 138 MET n 
1 139 ALA n 
1 140 ASP n 
1 141 PHE n 
1 142 GLU n 
1 143 ILE n 
1 144 GLY n 
1 145 ILE n 
1 146 ARG n 
1 147 ALA n 
1 148 ILE n 
1 149 SER n 
1 150 ILE n 
1 151 ASP n 
1 152 ASN n 
1 153 ALA n 
1 154 SER n 
1 155 LEU n 
1 156 ALA n 
1 157 GLU n 
1 158 ASN n 
1 159 LEU n 
1 160 LEU n 
1 161 ILE n 
1 162 GLN n 
1 163 GLU n 
1 164 VAL n 
1 165 GLN n 
1 166 PHE n 
1 167 LEU n 
1 168 GLN n 
1 169 GLN n 
1 170 CYS n 
1 171 THR n 
1 172 THR n 
1 173 TYR n 
1 174 SER n 
1 175 MET n 
1 176 GLY n 
1 177 ILE n 
1 178 PHE n 
1 179 VAL n 
1 180 ASP n 
1 181 TRP n 
1 182 GLU n 
1 183 LEU n 
1 184 TYR n 
1 185 LYS n 
1 186 GLN n 
1 187 LEU n 
1 188 GLU n 
1 189 SER n 
1 190 VAL n 
1 191 ILE n 
1 192 LYS n 
1 193 ASP n 
1 194 LEU n 
1 195 GLU n 
1 196 TYR n 
1 197 ASN n 
1 198 ILE n 
1 199 TRP n 
1 200 PRO n 
1 201 ILE n 
1 202 PRO n 
1 203 GLY n 
1 204 THR n 
1 205 ARG n 
1 206 ALA n 
1 207 HIS n 
1 208 LEU n 
1 209 PHE n 
1 210 PRO n 
1 211 LYS n 
1 212 VAL n 
1 213 ALA n 
1 214 HIS n 
1 215 LEU n 
1 216 LEU n 
1 217 HIS n 
1 218 GLN n 
1 219 MET n 
1 220 PRO n 
1 221 TRP n 
1 222 GLY n 
1 223 GLU n 
1 224 LYS n 
1 225 ILE n 
1 226 ALA n 
1 227 SER n 
1 228 VAL n 
1 229 GLU n 
1 230 ILE n 
1 231 ALA n 
1 232 THR n 
1 233 GLU n 
1 234 THR n 
1 235 LEU n 
1 236 GLU n 
1 237 MET n 
1 238 TYR n 
1 239 ASN n 
1 240 GLU n 
1 241 PHE n 
1 242 MET n 
1 243 GLU n 
1 244 ALA n 
1 245 ALA n 
1 246 ARG n 
1 247 GLN n 
1 248 GLU n 
1 249 HIS n 
1 250 MET n 
1 251 CYS n 
1 252 LEU n 
1 253 MET n 
1 254 HIS n 
1 255 PHE n 
1 256 LYS n 
1 257 SER n 
1 258 ASP n 
1 259 ASP n 
1 260 ASN n 
1 261 VAL n 
1 262 TYR n 
1 263 ILE n 
1 264 MET n 
1 265 PHE n 
1 266 GLY n 
1 267 ASN n 
1 268 LYS n 
1 269 LEU n 
1 270 ALA n 
1 271 SER n 
1 272 HIS n 
1 273 PHE n 
1 274 LYS n 
1 275 GLU n 
1 276 ASN n 
1 277 GLY n 
1 278 THR n 
1 279 LEU n 
1 280 PHE n 
1 281 SER n 
1 282 VAL n 
1 283 PRO n 
1 284 THR n 
1 285 ASP n 
1 286 ARG n 
1 287 THR n 
1 288 ASP n 
1 289 ASP n 
1 290 GLU n 
1 291 PHE n 
1 292 LEU n 
1 293 ALA n 
1 294 ASP n 
1 295 LEU n 
1 296 PRO n 
1 297 ASN n 
1 298 ARG n 
1 299 ALA n 
1 300 PHE n 
1 301 VAL n 
1 302 LEU n 
1 303 MET n 
1 304 GLU n 
1 305 ASN n 
1 306 GLU n 
1 307 ILE n 
1 308 ASP n 
1 309 LEU n 
1 310 SER n 
1 311 THR n 
1 312 ALA n 
1 313 VAL n 
1 314 GLU n 
1 315 LEU n 
1 316 ASP n 
1 317 ALA n 
1 318 THR n 
1 319 PRO n 
1 320 THR n 
1 321 ALA n 
1 322 LEU n 
1 323 ASP n 
1 324 GLU n 
1 325 ILE n 
1 326 LEU n 
1 327 ILE n 
1 328 GLY n 
1 329 LYS n 
1 330 SER n 
1 331 VAL n 
1 332 LEU n 
1 333 PRO n 
1 334 SER n 
1 335 ARG n 
1 336 VAL n 
1 337 LEU n 
1 338 SER n 
1 339 PHE n 
1 340 ALA n 
1 341 GLY n 
1 342 SER n 
1 343 ILE n 
1 344 ILE n 
1 345 ASP n 
1 346 LEU n 
1 347 MET n 
1 348 ASN n 
1 349 TRP n 
1 350 LEU n 
1 351 ARG n 
1 352 GLY n 
1 353 SER n 
1 354 LEU n 
1 355 SER n 
1 356 LYS n 
1 357 HIS n 
1 358 CYS n 
1 359 LYS n 
1 360 ARG n 
1 361 GLY n 
1 362 GLU n 
1 363 GLU n 
1 364 HIS n 
1 365 ASP n 
1 366 LEU n 
1 367 TYR n 
1 368 VAL n 
1 369 LEU n 
1 370 GLU n 
1 371 SER n 
1 372 CYS n 
1 373 PHE n 
1 374 ASN n 
1 375 PHE n 
1 376 LEU n 
1 377 ASN n 
1 378 PHE n 
1 379 ILE n 
1 380 GLU n 
1 381 ASP n 
1 382 TRP n 
1 383 ARG n 
1 384 THR n 
1 385 SER n 
1 386 GLU n 
1 387 TYR n 
1 388 ARG n 
1 389 GLN n 
1 390 ALA n 
1 391 HIS n 
1 392 ASP n 
1 393 THR n 
1 394 ALA n 
1 395 GLU n 
1 396 ILE n 
1 397 LEU n 
1 398 SER n 
1 399 LEU n 
1 400 LEU n 
1 401 LEU n 
1 402 MET n 
1 403 ARG n 
1 404 LYS n 
1 405 LEU n 
1 406 GLY n 
1 407 THR n 
1 408 ALA n 
1 409 MET n 
1 410 ASN n 
1 411 PHE n 
1 412 GLN n 
1 413 MET n 
1 414 TYR n 
1 415 GLN n 
1 416 LYS n 
1 417 LYS n 
1 418 VAL n 
1 419 LEU n 
1 420 THR n 
1 421 LEU n 
1 422 ASP n 
1 423 LYS n 
1 424 ILE n 
1 425 THR n 
1 426 GLY n 
1 427 GLU n 
1 428 SER n 
1 429 ARG n 
1 430 THR n 
1 431 GLU n 
1 432 LEU n 
1 433 ARG n 
1 434 GLU n 
1 435 ILE n 
1 436 ALA n 
1 437 SER n 
1 438 GLN n 
1 439 ASN n 
1 440 PHE n 
1 441 VAL n 
1 442 THR n 
1 443 ASN n 
1 444 VAL n 
1 445 THR n 
1 446 THR n 
1 447 TYR n 
1 448 TYR n 
1 449 HIS n 
1 450 TYR n 
1 451 ASN n 
1 452 ARG n 
1 453 ASP n 
1 454 ASN n 
1 455 HIS n 
1 456 THR n 
1 457 SER n 
1 458 LEU n 
1 459 GLU n 
1 460 LEU n 
1 461 LYS n 
1 462 THR n 
1 463 LYS n 
1 464 PHE n 
1 465 GLY n 
1 466 GLN n 
1 467 VAL n 
1 468 PHE n 
1 469 ASN n 
1 470 CYS n 
1 471 GLN n 
1 472 TYR n 
1 473 SER n 
1 474 ALA n 
1 475 GLY n 
1 476 ASP n 
1 477 ASN n 
1 478 ARG n 
1 479 ARG n 
1 480 TYR n 
1 481 PRO n 
1 482 PHE n 
1 483 LEU n 
1 484 PHE n 
1 485 ASP n 
1 486 GLY n 
1 487 GLU n 
1 488 SER n 
1 489 VAL n 
1 490 MET n 
1 491 PHE n 
1 492 TRP n 
1 493 ARG n 
1 494 ILE n 
1 495 LYS n 
1 496 MET n 
1 497 ASP n 
1 498 THR n 
1 499 TRP n 
1 500 HIS n 
1 501 HIS n 
1 502 HIS n 
1 503 HIS n 
1 504 HIS n 
1 505 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   505 
_entity_src_gen.gene_src_common_name               'fruit fly' 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'boss, CG8285' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Drosophila melanogaster' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     7227 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               human 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'          y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'          y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'          y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking'          y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking'          y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'            y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'          y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking'          y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'          y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'          y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'          y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'          y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'          y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'          y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'          y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'          y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'          y VALINE                                   ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   CYS 1   32  ?   ?   ?   A . n 
A 1 2   HIS 2   33  ?   ?   ?   A . n 
A 1 3   GLY 3   34  ?   ?   ?   A . n 
A 1 4   ALA 4   35  ?   ?   ?   A . n 
A 1 5   ASP 5   36  ?   ?   ?   A . n 
A 1 6   LEU 6   37  ?   ?   ?   A . n 
A 1 7   THR 7   38  ?   ?   ?   A . n 
A 1 8   SER 8   39  ?   ?   ?   A . n 
A 1 9   PRO 9   40  ?   ?   ?   A . n 
A 1 10  THR 10  41  ?   ?   ?   A . n 
A 1 11  LYS 11  42  ?   ?   ?   A . n 
A 1 12  LYS 12  43  ?   ?   ?   A . n 
A 1 13  SER 13  44  ?   ?   ?   A . n 
A 1 14  ALA 14  45  ?   ?   ?   A . n 
A 1 15  PRO 15  46  ?   ?   ?   A . n 
A 1 16  LEU 16  47  ?   ?   ?   A . n 
A 1 17  ARG 17  48  ?   ?   ?   A . n 
A 1 18  ILE 18  49  ?   ?   ?   A . n 
A 1 19  THR 19  50  ?   ?   ?   A . n 
A 1 20  LYS 20  51  ?   ?   ?   A . n 
A 1 21  PRO 21  52  ?   ?   ?   A . n 
A 1 22  GLN 22  53  ?   ?   ?   A . n 
A 1 23  PRO 23  54  ?   ?   ?   A . n 
A 1 24  THR 24  55  ?   ?   ?   A . n 
A 1 25  SER 25  56  ?   ?   ?   A . n 
A 1 26  GLN 26  57  ?   ?   ?   A . n 
A 1 27  GLN 27  58  ?   ?   ?   A . n 
A 1 28  ALA 28  59  ?   ?   ?   A . n 
A 1 29  LYS 29  60  ?   ?   ?   A . n 
A 1 30  PRO 30  61  ?   ?   ?   A . n 
A 1 31  ILE 31  62  ?   ?   ?   A . n 
A 1 32  SER 32  63  ?   ?   ?   A . n 
A 1 33  ILE 33  64  ?   ?   ?   A . n 
A 1 34  THR 34  65  ?   ?   ?   A . n 
A 1 35  THR 35  66  ?   ?   ?   A . n 
A 1 36  ARG 36  67  ?   ?   ?   A . n 
A 1 37  ALA 37  68  ?   ?   ?   A . n 
A 1 38  PRO 38  69  ?   ?   ?   A . n 
A 1 39  THR 39  70  ?   ?   ?   A . n 
A 1 40  THR 40  71  ?   ?   ?   A . n 
A 1 41  VAL 41  72  ?   ?   ?   A . n 
A 1 42  ALA 42  73  ?   ?   ?   A . n 
A 1 43  SER 43  74  ?   ?   ?   A . n 
A 1 44  THR 44  75  ?   ?   ?   A . n 
A 1 45  THR 45  76  ?   ?   ?   A . n 
A 1 46  ASP 46  77  ?   ?   ?   A . n 
A 1 47  ASP 47  78  ?   ?   ?   A . n 
A 1 48  GLU 48  79  ?   ?   ?   A . n 
A 1 49  VAL 49  80  ?   ?   ?   A . n 
A 1 50  SER 50  81  ?   ?   ?   A . n 
A 1 51  SER 51  82  ?   ?   ?   A . n 
A 1 52  SER 52  83  ?   ?   ?   A . n 
A 1 53  VAL 53  84  ?   ?   ?   A . n 
A 1 54  ASP 54  85  ?   ?   ?   A . n 
A 1 55  GLY 55  86  ?   ?   ?   A . n 
A 1 56  GLN 56  87  ?   ?   ?   A . n 
A 1 57  LEU 57  88  ?   ?   ?   A . n 
A 1 58  ALA 58  89  ?   ?   ?   A . n 
A 1 59  PRO 59  90  ?   ?   ?   A . n 
A 1 60  LEU 60  91  ?   ?   ?   A . n 
A 1 61  ILE 61  92  ?   ?   ?   A . n 
A 1 62  SER 62  93  ?   ?   ?   A . n 
A 1 63  SER 63  94  ?   ?   ?   A . n 
A 1 64  THR 64  95  ?   ?   ?   A . n 
A 1 65  THR 65  96  ?   ?   ?   A . n 
A 1 66  GLU 66  97  ?   ?   ?   A . n 
A 1 67  GLY 67  98  ?   ?   ?   A . n 
A 1 68  PRO 68  99  ?   ?   ?   A . n 
A 1 69  SER 69  100 ?   ?   ?   A . n 
A 1 70  SER 70  101 ?   ?   ?   A . n 
A 1 71  GLY 71  102 ?   ?   ?   A . n 
A 1 72  THR 72  103 ?   ?   ?   A . n 
A 1 73  THR 73  104 ?   ?   ?   A . n 
A 1 74  ALA 74  105 ?   ?   ?   A . n 
A 1 75  SER 75  106 ?   ?   ?   A . n 
A 1 76  LEU 76  107 ?   ?   ?   A . n 
A 1 77  VAL 77  108 108 VAL VAL A . n 
A 1 78  PRO 78  109 109 PRO PRO A . n 
A 1 79  GLU 79  110 110 GLU GLU A . n 
A 1 80  ILE 80  111 111 ILE ILE A . n 
A 1 81  CYS 81  112 112 CYS CYS A . n 
A 1 82  LEU 82  113 113 LEU LEU A . n 
A 1 83  ASN 83  114 114 ASN ASN A . n 
A 1 84  GLY 84  115 115 GLY GLY A . n 
A 1 85  LEU 85  116 116 LEU LEU A . n 
A 1 86  GLN 86  117 117 GLN GLN A . n 
A 1 87  LEU 87  118 118 LEU LEU A . n 
A 1 88  THR 88  119 119 THR THR A . n 
A 1 89  VAL 89  120 120 VAL VAL A . n 
A 1 90  ASN 90  121 ?   ?   ?   A . n 
A 1 91  SER 91  122 ?   ?   ?   A . n 
A 1 92  ALA 92  123 ?   ?   ?   A . n 
A 1 93  ASP 93  124 ?   ?   ?   A . n 
A 1 94  GLU 94  125 ?   ?   ?   A . n 
A 1 95  GLY 95  126 ?   ?   ?   A . n 
A 1 96  THR 96  127 127 THR THR A . n 
A 1 97  VAL 97  128 128 VAL VAL A . n 
A 1 98  ILE 98  129 129 ILE ILE A . n 
A 1 99  ARG 99  130 130 ARG ARG A . n 
A 1 100 LYS 100 131 131 LYS LYS A . n 
A 1 101 GLN 101 132 132 GLN GLN A . n 
A 1 102 GLU 102 133 133 GLU GLU A . n 
A 1 103 GLU 103 134 134 GLU GLU A . n 
A 1 104 PHE 104 135 135 PHE PHE A . n 
A 1 105 VAL 105 136 136 VAL VAL A . n 
A 1 106 LYS 106 137 137 LYS LYS A . n 
A 1 107 ILE 107 138 138 ILE ILE A . n 
A 1 108 LEU 108 139 139 LEU LEU A . n 
A 1 109 GLU 109 140 140 GLU GLU A . n 
A 1 110 GLY 110 141 141 GLY GLY A . n 
A 1 111 ASP 111 142 142 ASP ASP A . n 
A 1 112 VAL 112 143 143 VAL VAL A . n 
A 1 113 VAL 113 144 144 VAL VAL A . n 
A 1 114 LEU 114 145 145 LEU LEU A . n 
A 1 115 SER 115 146 146 SER SER A . n 
A 1 116 VAL 116 147 147 VAL VAL A . n 
A 1 117 LEU 117 148 148 LEU LEU A . n 
A 1 118 THR 118 149 149 THR THR A . n 
A 1 119 LYS 119 150 150 LYS LYS A . n 
A 1 120 ASP 120 151 151 ASP ASP A . n 
A 1 121 PRO 121 152 152 PRO PRO A . n 
A 1 122 ASP 122 153 153 ASP ASP A . n 
A 1 123 SER 123 154 154 SER SER A . n 
A 1 124 ALA 124 155 155 ALA ALA A . n 
A 1 125 LEU 125 156 156 LEU LEU A . n 
A 1 126 PHE 126 157 157 PHE PHE A . n 
A 1 127 VAL 127 158 158 VAL VAL A . n 
A 1 128 ILE 128 159 159 ILE ILE A . n 
A 1 129 ASN 129 160 160 ASN ASN A . n 
A 1 130 ARG 130 161 161 ARG ARG A . n 
A 1 131 VAL 131 162 162 VAL VAL A . n 
A 1 132 ASN 132 163 163 ASN ASN A . n 
A 1 133 GLN 133 164 164 GLN GLN A . n 
A 1 134 ALA 134 165 165 ALA ALA A . n 
A 1 135 ASN 135 166 166 ASN ASN A . n 
A 1 136 LEU 136 167 167 LEU LEU A . n 
A 1 137 ILE 137 168 168 ILE ILE A . n 
A 1 138 MET 138 169 169 MET MET A . n 
A 1 139 ALA 139 170 170 ALA ALA A . n 
A 1 140 ASP 140 171 171 ASP ASP A . n 
A 1 141 PHE 141 172 172 PHE PHE A . n 
A 1 142 GLU 142 173 173 GLU GLU A . n 
A 1 143 ILE 143 174 174 ILE ILE A . n 
A 1 144 GLY 144 175 175 GLY GLY A . n 
A 1 145 ILE 145 176 176 ILE ILE A . n 
A 1 146 ARG 146 177 177 ARG ARG A . n 
A 1 147 ALA 147 178 178 ALA ALA A . n 
A 1 148 ILE 148 179 179 ILE ILE A . n 
A 1 149 SER 149 180 180 SER SER A . n 
A 1 150 ILE 150 181 181 ILE ILE A . n 
A 1 151 ASP 151 182 182 ASP ASP A . n 
A 1 152 ASN 152 183 183 ASN ASN A . n 
A 1 153 ALA 153 184 184 ALA ALA A . n 
A 1 154 SER 154 185 185 SER SER A . n 
A 1 155 LEU 155 186 186 LEU LEU A . n 
A 1 156 ALA 156 187 187 ALA ALA A . n 
A 1 157 GLU 157 188 188 GLU GLU A . n 
A 1 158 ASN 158 189 189 ASN ASN A . n 
A 1 159 LEU 159 190 190 LEU LEU A . n 
A 1 160 LEU 160 191 191 LEU LEU A . n 
A 1 161 ILE 161 192 192 ILE ILE A . n 
A 1 162 GLN 162 193 193 GLN GLN A . n 
A 1 163 GLU 163 194 194 GLU GLU A . n 
A 1 164 VAL 164 195 195 VAL VAL A . n 
A 1 165 GLN 165 196 196 GLN GLN A . n 
A 1 166 PHE 166 197 197 PHE PHE A . n 
A 1 167 LEU 167 198 198 LEU LEU A . n 
A 1 168 GLN 168 199 199 GLN GLN A . n 
A 1 169 GLN 169 200 200 GLN GLN A . n 
A 1 170 CYS 170 201 201 CYS CYS A . n 
A 1 171 THR 171 202 202 THR THR A . n 
A 1 172 THR 172 203 203 THR THR A . n 
A 1 173 TYR 173 204 204 TYR TYR A . n 
A 1 174 SER 174 205 205 SER SER A . n 
A 1 175 MET 175 206 206 MET MET A . n 
A 1 176 GLY 176 207 207 GLY GLY A . n 
A 1 177 ILE 177 208 208 ILE ILE A . n 
A 1 178 PHE 178 209 209 PHE PHE A . n 
A 1 179 VAL 179 210 210 VAL VAL A . n 
A 1 180 ASP 180 211 211 ASP ASP A . n 
A 1 181 TRP 181 212 212 TRP TRP A . n 
A 1 182 GLU 182 213 213 GLU GLU A . n 
A 1 183 LEU 183 214 214 LEU LEU A . n 
A 1 184 TYR 184 215 215 TYR TYR A . n 
A 1 185 LYS 185 216 216 LYS LYS A . n 
A 1 186 GLN 186 217 217 GLN GLN A . n 
A 1 187 LEU 187 218 218 LEU LEU A . n 
A 1 188 GLU 188 219 219 GLU GLU A . n 
A 1 189 SER 189 220 220 SER SER A . n 
A 1 190 VAL 190 221 221 VAL VAL A . n 
A 1 191 ILE 191 222 222 ILE ILE A . n 
A 1 192 LYS 192 223 223 LYS LYS A . n 
A 1 193 ASP 193 224 224 ASP ASP A . n 
A 1 194 LEU 194 225 225 LEU LEU A . n 
A 1 195 GLU 195 226 226 GLU GLU A . n 
A 1 196 TYR 196 227 227 TYR TYR A . n 
A 1 197 ASN 197 228 228 ASN ASN A . n 
A 1 198 ILE 198 229 229 ILE ILE A . n 
A 1 199 TRP 199 230 230 TRP TRP A . n 
A 1 200 PRO 200 231 231 PRO PRO A . n 
A 1 201 ILE 201 232 232 ILE ILE A . n 
A 1 202 PRO 202 233 233 PRO PRO A . n 
A 1 203 GLY 203 234 234 GLY GLY A . n 
A 1 204 THR 204 235 235 THR THR A . n 
A 1 205 ARG 205 236 236 ARG ARG A . n 
A 1 206 ALA 206 237 237 ALA ALA A . n 
A 1 207 HIS 207 238 238 HIS HIS A . n 
A 1 208 LEU 208 239 239 LEU LEU A . n 
A 1 209 PHE 209 240 240 PHE PHE A . n 
A 1 210 PRO 210 241 241 PRO PRO A . n 
A 1 211 LYS 211 242 242 LYS LYS A . n 
A 1 212 VAL 212 243 243 VAL VAL A . n 
A 1 213 ALA 213 244 244 ALA ALA A . n 
A 1 214 HIS 214 245 245 HIS HIS A . n 
A 1 215 LEU 215 246 246 LEU LEU A . n 
A 1 216 LEU 216 247 247 LEU LEU A . n 
A 1 217 HIS 217 248 248 HIS HIS A . n 
A 1 218 GLN 218 249 249 GLN GLN A . n 
A 1 219 MET 219 250 250 MET MET A . n 
A 1 220 PRO 220 251 251 PRO PRO A . n 
A 1 221 TRP 221 252 252 TRP TRP A . n 
A 1 222 GLY 222 253 253 GLY GLY A . n 
A 1 223 GLU 223 254 254 GLU GLU A . n 
A 1 224 LYS 224 255 255 LYS LYS A . n 
A 1 225 ILE 225 256 256 ILE ILE A . n 
A 1 226 ALA 226 257 257 ALA ALA A . n 
A 1 227 SER 227 258 258 SER SER A . n 
A 1 228 VAL 228 259 259 VAL VAL A . n 
A 1 229 GLU 229 260 260 GLU GLU A . n 
A 1 230 ILE 230 261 261 ILE ILE A . n 
A 1 231 ALA 231 262 262 ALA ALA A . n 
A 1 232 THR 232 263 263 THR THR A . n 
A 1 233 GLU 233 264 264 GLU GLU A . n 
A 1 234 THR 234 265 265 THR THR A . n 
A 1 235 LEU 235 266 266 LEU LEU A . n 
A 1 236 GLU 236 267 267 GLU GLU A . n 
A 1 237 MET 237 268 268 MET MET A . n 
A 1 238 TYR 238 269 269 TYR TYR A . n 
A 1 239 ASN 239 270 270 ASN ASN A . n 
A 1 240 GLU 240 271 271 GLU GLU A . n 
A 1 241 PHE 241 272 272 PHE PHE A . n 
A 1 242 MET 242 273 273 MET MET A . n 
A 1 243 GLU 243 274 274 GLU GLU A . n 
A 1 244 ALA 244 275 275 ALA ALA A . n 
A 1 245 ALA 245 276 276 ALA ALA A . n 
A 1 246 ARG 246 277 277 ARG ARG A . n 
A 1 247 GLN 247 278 278 GLN GLN A . n 
A 1 248 GLU 248 279 279 GLU GLU A . n 
A 1 249 HIS 249 280 280 HIS HIS A . n 
A 1 250 MET 250 281 281 MET MET A . n 
A 1 251 CYS 251 282 282 CYS CYS A . n 
A 1 252 LEU 252 283 283 LEU LEU A . n 
A 1 253 MET 253 284 284 MET MET A . n 
A 1 254 HIS 254 285 285 HIS HIS A . n 
A 1 255 PHE 255 286 286 PHE PHE A . n 
A 1 256 LYS 256 287 287 LYS LYS A . n 
A 1 257 SER 257 288 288 SER SER A . n 
A 1 258 ASP 258 289 289 ASP ASP A . n 
A 1 259 ASP 259 290 290 ASP ASP A . n 
A 1 260 ASN 260 291 291 ASN ASN A . n 
A 1 261 VAL 261 292 292 VAL VAL A . n 
A 1 262 TYR 262 293 293 TYR TYR A . n 
A 1 263 ILE 263 294 294 ILE ILE A . n 
A 1 264 MET 264 295 295 MET MET A . n 
A 1 265 PHE 265 296 296 PHE PHE A . n 
A 1 266 GLY 266 297 297 GLY GLY A . n 
A 1 267 ASN 267 298 298 ASN ASN A . n 
A 1 268 LYS 268 299 299 LYS LYS A . n 
A 1 269 LEU 269 300 300 LEU LEU A . n 
A 1 270 ALA 270 301 301 ALA ALA A . n 
A 1 271 SER 271 302 302 SER SER A . n 
A 1 272 HIS 272 303 303 HIS HIS A . n 
A 1 273 PHE 273 304 304 PHE PHE A . n 
A 1 274 LYS 274 305 305 LYS LYS A . n 
A 1 275 GLU 275 306 306 GLU GLU A . n 
A 1 276 ASN 276 307 307 ASN ASN A . n 
A 1 277 GLY 277 308 308 GLY GLY A . n 
A 1 278 THR 278 309 309 THR THR A . n 
A 1 279 LEU 279 310 310 LEU LEU A . n 
A 1 280 PHE 280 311 311 PHE PHE A . n 
A 1 281 SER 281 312 312 SER SER A . n 
A 1 282 VAL 282 313 313 VAL VAL A . n 
A 1 283 PRO 283 314 314 PRO PRO A . n 
A 1 284 THR 284 315 315 THR THR A . n 
A 1 285 ASP 285 316 316 ASP ASP A . n 
A 1 286 ARG 286 317 317 ARG ARG A . n 
A 1 287 THR 287 318 318 THR THR A . n 
A 1 288 ASP 288 319 319 ASP ASP A . n 
A 1 289 ASP 289 320 320 ASP ASP A . n 
A 1 290 GLU 290 321 321 GLU GLU A . n 
A 1 291 PHE 291 322 322 PHE PHE A . n 
A 1 292 LEU 292 323 323 LEU LEU A . n 
A 1 293 ALA 293 324 324 ALA ALA A . n 
A 1 294 ASP 294 325 325 ASP ASP A . n 
A 1 295 LEU 295 326 326 LEU LEU A . n 
A 1 296 PRO 296 327 327 PRO PRO A . n 
A 1 297 ASN 297 328 328 ASN ASN A . n 
A 1 298 ARG 298 329 329 ARG ARG A . n 
A 1 299 ALA 299 330 330 ALA ALA A . n 
A 1 300 PHE 300 331 331 PHE PHE A . n 
A 1 301 VAL 301 332 332 VAL VAL A . n 
A 1 302 LEU 302 333 333 LEU LEU A . n 
A 1 303 MET 303 334 334 MET MET A . n 
A 1 304 GLU 304 335 335 GLU GLU A . n 
A 1 305 ASN 305 336 336 ASN ASN A . n 
A 1 306 GLU 306 337 337 GLU GLU A . n 
A 1 307 ILE 307 338 338 ILE ILE A . n 
A 1 308 ASP 308 339 339 ASP ASP A . n 
A 1 309 LEU 309 340 340 LEU LEU A . n 
A 1 310 SER 310 341 341 SER SER A . n 
A 1 311 THR 311 342 342 THR THR A . n 
A 1 312 ALA 312 343 343 ALA ALA A . n 
A 1 313 VAL 313 344 344 VAL VAL A . n 
A 1 314 GLU 314 345 345 GLU GLU A . n 
A 1 315 LEU 315 346 346 LEU LEU A . n 
A 1 316 ASP 316 347 347 ASP ASP A . n 
A 1 317 ALA 317 348 348 ALA ALA A . n 
A 1 318 THR 318 349 349 THR THR A . n 
A 1 319 PRO 319 350 350 PRO PRO A . n 
A 1 320 THR 320 351 351 THR THR A . n 
A 1 321 ALA 321 352 352 ALA ALA A . n 
A 1 322 LEU 322 353 353 LEU LEU A . n 
A 1 323 ASP 323 354 354 ASP ASP A . n 
A 1 324 GLU 324 355 355 GLU GLU A . n 
A 1 325 ILE 325 356 356 ILE ILE A . n 
A 1 326 LEU 326 357 357 LEU LEU A . n 
A 1 327 ILE 327 358 358 ILE ILE A . n 
A 1 328 GLY 328 359 359 GLY GLY A . n 
A 1 329 LYS 329 360 360 LYS LYS A . n 
A 1 330 SER 330 361 361 SER SER A . n 
A 1 331 VAL 331 362 362 VAL VAL A . n 
A 1 332 LEU 332 363 363 LEU LEU A . n 
A 1 333 PRO 333 364 364 PRO PRO A . n 
A 1 334 SER 334 365 365 SER SER A . n 
A 1 335 ARG 335 366 366 ARG ARG A . n 
A 1 336 VAL 336 367 367 VAL VAL A . n 
A 1 337 LEU 337 368 368 LEU LEU A . n 
A 1 338 SER 338 369 369 SER SER A . n 
A 1 339 PHE 339 370 370 PHE PHE A . n 
A 1 340 ALA 340 371 371 ALA ALA A . n 
A 1 341 GLY 341 372 372 GLY GLY A . n 
A 1 342 SER 342 373 373 SER SER A . n 
A 1 343 ILE 343 374 374 ILE ILE A . n 
A 1 344 ILE 344 375 375 ILE ILE A . n 
A 1 345 ASP 345 376 376 ASP ASP A . n 
A 1 346 LEU 346 377 377 LEU LEU A . n 
A 1 347 MET 347 378 378 MET MET A . n 
A 1 348 ASN 348 379 379 ASN ASN A . n 
A 1 349 TRP 349 380 380 TRP TRP A . n 
A 1 350 LEU 350 381 381 LEU LEU A . n 
A 1 351 ARG 351 382 382 ARG ARG A . n 
A 1 352 GLY 352 383 383 GLY GLY A . n 
A 1 353 SER 353 384 384 SER SER A . n 
A 1 354 LEU 354 385 385 LEU LEU A . n 
A 1 355 SER 355 386 386 SER SER A . n 
A 1 356 LYS 356 387 387 LYS LYS A . n 
A 1 357 HIS 357 388 388 HIS HIS A . n 
A 1 358 CYS 358 389 389 CYS CYS A . n 
A 1 359 LYS 359 390 390 LYS LYS A . n 
A 1 360 ARG 360 391 391 ARG ARG A . n 
A 1 361 GLY 361 392 ?   ?   ?   A . n 
A 1 362 GLU 362 393 ?   ?   ?   A . n 
A 1 363 GLU 363 394 ?   ?   ?   A . n 
A 1 364 HIS 364 395 ?   ?   ?   A . n 
A 1 365 ASP 365 396 396 ASP ASP A . n 
A 1 366 LEU 366 397 397 LEU LEU A . n 
A 1 367 TYR 367 398 398 TYR TYR A . n 
A 1 368 VAL 368 399 399 VAL VAL A . n 
A 1 369 LEU 369 400 400 LEU LEU A . n 
A 1 370 GLU 370 401 401 GLU GLU A . n 
A 1 371 SER 371 402 402 SER SER A . n 
A 1 372 CYS 372 403 403 CYS CYS A . n 
A 1 373 PHE 373 404 404 PHE PHE A . n 
A 1 374 ASN 374 405 405 ASN ASN A . n 
A 1 375 PHE 375 406 406 PHE PHE A . n 
A 1 376 LEU 376 407 407 LEU LEU A . n 
A 1 377 ASN 377 408 408 ASN ASN A . n 
A 1 378 PHE 378 409 409 PHE PHE A . n 
A 1 379 ILE 379 410 410 ILE ILE A . n 
A 1 380 GLU 380 411 411 GLU GLU A . n 
A 1 381 ASP 381 412 412 ASP ASP A . n 
A 1 382 TRP 382 413 413 TRP TRP A . n 
A 1 383 ARG 383 414 414 ARG ARG A . n 
A 1 384 THR 384 415 415 THR THR A . n 
A 1 385 SER 385 416 416 SER SER A . n 
A 1 386 GLU 386 417 417 GLU GLU A . n 
A 1 387 TYR 387 418 418 TYR TYR A . n 
A 1 388 ARG 388 419 419 ARG ARG A . n 
A 1 389 GLN 389 420 420 GLN GLN A . n 
A 1 390 ALA 390 421 421 ALA ALA A . n 
A 1 391 HIS 391 422 422 HIS HIS A . n 
A 1 392 ASP 392 423 423 ASP ASP A . n 
A 1 393 THR 393 424 424 THR THR A . n 
A 1 394 ALA 394 425 425 ALA ALA A . n 
A 1 395 GLU 395 426 426 GLU GLU A . n 
A 1 396 ILE 396 427 427 ILE ILE A . n 
A 1 397 LEU 397 428 428 LEU LEU A . n 
A 1 398 SER 398 429 429 SER SER A . n 
A 1 399 LEU 399 430 430 LEU LEU A . n 
A 1 400 LEU 400 431 431 LEU LEU A . n 
A 1 401 LEU 401 432 432 LEU LEU A . n 
A 1 402 MET 402 433 433 MET MET A . n 
A 1 403 ARG 403 434 434 ARG ARG A . n 
A 1 404 LYS 404 435 435 LYS LYS A . n 
A 1 405 LEU 405 436 436 LEU LEU A . n 
A 1 406 GLY 406 437 437 GLY GLY A . n 
A 1 407 THR 407 438 438 THR THR A . n 
A 1 408 ALA 408 439 439 ALA ALA A . n 
A 1 409 MET 409 440 440 MET MET A . n 
A 1 410 ASN 410 441 441 ASN ASN A . n 
A 1 411 PHE 411 442 442 PHE PHE A . n 
A 1 412 GLN 412 443 443 GLN GLN A . n 
A 1 413 MET 413 444 444 MET MET A . n 
A 1 414 TYR 414 445 445 TYR TYR A . n 
A 1 415 GLN 415 446 446 GLN GLN A . n 
A 1 416 LYS 416 447 447 LYS LYS A . n 
A 1 417 LYS 417 448 448 LYS LYS A . n 
A 1 418 VAL 418 449 449 VAL VAL A . n 
A 1 419 LEU 419 450 450 LEU LEU A . n 
A 1 420 THR 420 451 ?   ?   ?   A . n 
A 1 421 LEU 421 452 ?   ?   ?   A . n 
A 1 422 ASP 422 453 ?   ?   ?   A . n 
A 1 423 LYS 423 454 ?   ?   ?   A . n 
A 1 424 ILE 424 455 ?   ?   ?   A . n 
A 1 425 THR 425 456 ?   ?   ?   A . n 
A 1 426 GLY 426 457 ?   ?   ?   A . n 
A 1 427 GLU 427 458 ?   ?   ?   A . n 
A 1 428 SER 428 459 ?   ?   ?   A . n 
A 1 429 ARG 429 460 ?   ?   ?   A . n 
A 1 430 THR 430 461 461 THR THR A . n 
A 1 431 GLU 431 462 462 GLU GLU A . n 
A 1 432 LEU 432 463 463 LEU LEU A . n 
A 1 433 ARG 433 464 464 ARG ARG A . n 
A 1 434 GLU 434 465 465 GLU GLU A . n 
A 1 435 ILE 435 466 466 ILE ILE A . n 
A 1 436 ALA 436 467 467 ALA ALA A . n 
A 1 437 SER 437 468 468 SER SER A . n 
A 1 438 GLN 438 469 469 GLN GLN A . n 
A 1 439 ASN 439 470 470 ASN ASN A . n 
A 1 440 PHE 440 471 471 PHE PHE A . n 
A 1 441 VAL 441 472 472 VAL VAL A . n 
A 1 442 THR 442 473 473 THR THR A . n 
A 1 443 ASN 443 474 474 ASN ASN A . n 
A 1 444 VAL 444 475 475 VAL VAL A . n 
A 1 445 THR 445 476 476 THR THR A . n 
A 1 446 THR 446 477 477 THR THR A . n 
A 1 447 TYR 447 478 478 TYR TYR A . n 
A 1 448 TYR 448 479 479 TYR TYR A . n 
A 1 449 HIS 449 480 480 HIS HIS A . n 
A 1 450 TYR 450 481 481 TYR TYR A . n 
A 1 451 ASN 451 482 482 ASN ASN A . n 
A 1 452 ARG 452 483 483 ARG ARG A . n 
A 1 453 ASP 453 484 484 ASP ASP A . n 
A 1 454 ASN 454 485 485 ASN ASN A . n 
A 1 455 HIS 455 486 486 HIS HIS A . n 
A 1 456 THR 456 487 487 THR THR A . n 
A 1 457 SER 457 488 488 SER SER A . n 
A 1 458 LEU 458 489 489 LEU LEU A . n 
A 1 459 GLU 459 490 490 GLU GLU A . n 
A 1 460 LEU 460 491 491 LEU LEU A . n 
A 1 461 LYS 461 492 492 LYS LYS A . n 
A 1 462 THR 462 493 493 THR THR A . n 
A 1 463 LYS 463 494 494 LYS LYS A . n 
A 1 464 PHE 464 495 495 PHE PHE A . n 
A 1 465 GLY 465 496 496 GLY GLY A . n 
A 1 466 GLN 466 497 497 GLN GLN A . n 
A 1 467 VAL 467 498 498 VAL VAL A . n 
A 1 468 PHE 468 499 499 PHE PHE A . n 
A 1 469 ASN 469 500 500 ASN ASN A . n 
A 1 470 CYS 470 501 501 CYS CYS A . n 
A 1 471 GLN 471 502 ?   ?   ?   A . n 
A 1 472 TYR 472 503 ?   ?   ?   A . n 
A 1 473 SER 473 504 ?   ?   ?   A . n 
A 1 474 ALA 474 505 ?   ?   ?   A . n 
A 1 475 GLY 475 506 ?   ?   ?   A . n 
A 1 476 ASP 476 507 ?   ?   ?   A . n 
A 1 477 ASN 477 508 ?   ?   ?   A . n 
A 1 478 ARG 478 509 ?   ?   ?   A . n 
A 1 479 ARG 479 510 ?   ?   ?   A . n 
A 1 480 TYR 480 511 ?   ?   ?   A . n 
A 1 481 PRO 481 512 ?   ?   ?   A . n 
A 1 482 PHE 482 513 ?   ?   ?   A . n 
A 1 483 LEU 483 514 ?   ?   ?   A . n 
A 1 484 PHE 484 515 ?   ?   ?   A . n 
A 1 485 ASP 485 516 ?   ?   ?   A . n 
A 1 486 GLY 486 517 ?   ?   ?   A . n 
A 1 487 GLU 487 518 ?   ?   ?   A . n 
A 1 488 SER 488 519 ?   ?   ?   A . n 
A 1 489 VAL 489 520 ?   ?   ?   A . n 
A 1 490 MET 490 521 521 MET MET A . n 
A 1 491 PHE 491 522 522 PHE PHE A . n 
A 1 492 TRP 492 523 523 TRP TRP A . n 
A 1 493 ARG 493 524 524 ARG ARG A . n 
A 1 494 ILE 494 525 525 ILE ILE A . n 
A 1 495 LYS 495 526 526 LYS LYS A . n 
A 1 496 MET 496 527 527 MET MET A . n 
A 1 497 ASP 497 528 528 ASP ASP A . n 
A 1 498 THR 498 529 529 THR THR A . n 
A 1 499 TRP 499 530 ?   ?   ?   A . n 
A 1 500 HIS 500 531 ?   ?   ?   A . n 
A 1 501 HIS 501 532 ?   ?   ?   A . n 
A 1 502 HIS 502 533 ?   ?   ?   A . n 
A 1 503 HIS 503 534 ?   ?   ?   A . n 
A 1 504 HIS 504 535 ?   ?   ?   A . n 
A 1 505 HIS 505 536 ?   ?   ?   A . n 
B 1 1   CYS 1   32  ?   ?   ?   B . n 
B 1 2   HIS 2   33  ?   ?   ?   B . n 
B 1 3   GLY 3   34  ?   ?   ?   B . n 
B 1 4   ALA 4   35  ?   ?   ?   B . n 
B 1 5   ASP 5   36  ?   ?   ?   B . n 
B 1 6   LEU 6   37  ?   ?   ?   B . n 
B 1 7   THR 7   38  ?   ?   ?   B . n 
B 1 8   SER 8   39  ?   ?   ?   B . n 
B 1 9   PRO 9   40  ?   ?   ?   B . n 
B 1 10  THR 10  41  ?   ?   ?   B . n 
B 1 11  LYS 11  42  ?   ?   ?   B . n 
B 1 12  LYS 12  43  ?   ?   ?   B . n 
B 1 13  SER 13  44  ?   ?   ?   B . n 
B 1 14  ALA 14  45  ?   ?   ?   B . n 
B 1 15  PRO 15  46  ?   ?   ?   B . n 
B 1 16  LEU 16  47  ?   ?   ?   B . n 
B 1 17  ARG 17  48  ?   ?   ?   B . n 
B 1 18  ILE 18  49  ?   ?   ?   B . n 
B 1 19  THR 19  50  ?   ?   ?   B . n 
B 1 20  LYS 20  51  ?   ?   ?   B . n 
B 1 21  PRO 21  52  ?   ?   ?   B . n 
B 1 22  GLN 22  53  ?   ?   ?   B . n 
B 1 23  PRO 23  54  ?   ?   ?   B . n 
B 1 24  THR 24  55  ?   ?   ?   B . n 
B 1 25  SER 25  56  ?   ?   ?   B . n 
B 1 26  GLN 26  57  ?   ?   ?   B . n 
B 1 27  GLN 27  58  ?   ?   ?   B . n 
B 1 28  ALA 28  59  ?   ?   ?   B . n 
B 1 29  LYS 29  60  ?   ?   ?   B . n 
B 1 30  PRO 30  61  ?   ?   ?   B . n 
B 1 31  ILE 31  62  ?   ?   ?   B . n 
B 1 32  SER 32  63  ?   ?   ?   B . n 
B 1 33  ILE 33  64  ?   ?   ?   B . n 
B 1 34  THR 34  65  ?   ?   ?   B . n 
B 1 35  THR 35  66  ?   ?   ?   B . n 
B 1 36  ARG 36  67  ?   ?   ?   B . n 
B 1 37  ALA 37  68  ?   ?   ?   B . n 
B 1 38  PRO 38  69  ?   ?   ?   B . n 
B 1 39  THR 39  70  ?   ?   ?   B . n 
B 1 40  THR 40  71  ?   ?   ?   B . n 
B 1 41  VAL 41  72  ?   ?   ?   B . n 
B 1 42  ALA 42  73  ?   ?   ?   B . n 
B 1 43  SER 43  74  ?   ?   ?   B . n 
B 1 44  THR 44  75  ?   ?   ?   B . n 
B 1 45  THR 45  76  ?   ?   ?   B . n 
B 1 46  ASP 46  77  ?   ?   ?   B . n 
B 1 47  ASP 47  78  ?   ?   ?   B . n 
B 1 48  GLU 48  79  ?   ?   ?   B . n 
B 1 49  VAL 49  80  ?   ?   ?   B . n 
B 1 50  SER 50  81  ?   ?   ?   B . n 
B 1 51  SER 51  82  ?   ?   ?   B . n 
B 1 52  SER 52  83  ?   ?   ?   B . n 
B 1 53  VAL 53  84  ?   ?   ?   B . n 
B 1 54  ASP 54  85  ?   ?   ?   B . n 
B 1 55  GLY 55  86  ?   ?   ?   B . n 
B 1 56  GLN 56  87  ?   ?   ?   B . n 
B 1 57  LEU 57  88  ?   ?   ?   B . n 
B 1 58  ALA 58  89  ?   ?   ?   B . n 
B 1 59  PRO 59  90  ?   ?   ?   B . n 
B 1 60  LEU 60  91  ?   ?   ?   B . n 
B 1 61  ILE 61  92  ?   ?   ?   B . n 
B 1 62  SER 62  93  ?   ?   ?   B . n 
B 1 63  SER 63  94  ?   ?   ?   B . n 
B 1 64  THR 64  95  ?   ?   ?   B . n 
B 1 65  THR 65  96  ?   ?   ?   B . n 
B 1 66  GLU 66  97  ?   ?   ?   B . n 
B 1 67  GLY 67  98  ?   ?   ?   B . n 
B 1 68  PRO 68  99  ?   ?   ?   B . n 
B 1 69  SER 69  100 ?   ?   ?   B . n 
B 1 70  SER 70  101 ?   ?   ?   B . n 
B 1 71  GLY 71  102 ?   ?   ?   B . n 
B 1 72  THR 72  103 ?   ?   ?   B . n 
B 1 73  THR 73  104 ?   ?   ?   B . n 
B 1 74  ALA 74  105 ?   ?   ?   B . n 
B 1 75  SER 75  106 ?   ?   ?   B . n 
B 1 76  LEU 76  107 ?   ?   ?   B . n 
B 1 77  VAL 77  108 108 VAL VAL B . n 
B 1 78  PRO 78  109 109 PRO PRO B . n 
B 1 79  GLU 79  110 110 GLU GLU B . n 
B 1 80  ILE 80  111 111 ILE ILE B . n 
B 1 81  CYS 81  112 112 CYS CYS B . n 
B 1 82  LEU 82  113 113 LEU LEU B . n 
B 1 83  ASN 83  114 114 ASN ASN B . n 
B 1 84  GLY 84  115 115 GLY GLY B . n 
B 1 85  LEU 85  116 116 LEU LEU B . n 
B 1 86  GLN 86  117 117 GLN GLN B . n 
B 1 87  LEU 87  118 118 LEU LEU B . n 
B 1 88  THR 88  119 119 THR THR B . n 
B 1 89  VAL 89  120 120 VAL VAL B . n 
B 1 90  ASN 90  121 ?   ?   ?   B . n 
B 1 91  SER 91  122 ?   ?   ?   B . n 
B 1 92  ALA 92  123 ?   ?   ?   B . n 
B 1 93  ASP 93  124 ?   ?   ?   B . n 
B 1 94  GLU 94  125 ?   ?   ?   B . n 
B 1 95  GLY 95  126 ?   ?   ?   B . n 
B 1 96  THR 96  127 127 THR THR B . n 
B 1 97  VAL 97  128 128 VAL VAL B . n 
B 1 98  ILE 98  129 129 ILE ILE B . n 
B 1 99  ARG 99  130 130 ARG ARG B . n 
B 1 100 LYS 100 131 131 LYS LYS B . n 
B 1 101 GLN 101 132 132 GLN GLN B . n 
B 1 102 GLU 102 133 133 GLU GLU B . n 
B 1 103 GLU 103 134 134 GLU GLU B . n 
B 1 104 PHE 104 135 135 PHE PHE B . n 
B 1 105 VAL 105 136 136 VAL VAL B . n 
B 1 106 LYS 106 137 137 LYS LYS B . n 
B 1 107 ILE 107 138 138 ILE ILE B . n 
B 1 108 LEU 108 139 139 LEU LEU B . n 
B 1 109 GLU 109 140 140 GLU GLU B . n 
B 1 110 GLY 110 141 141 GLY GLY B . n 
B 1 111 ASP 111 142 142 ASP ASP B . n 
B 1 112 VAL 112 143 143 VAL VAL B . n 
B 1 113 VAL 113 144 144 VAL VAL B . n 
B 1 114 LEU 114 145 145 LEU LEU B . n 
B 1 115 SER 115 146 146 SER SER B . n 
B 1 116 VAL 116 147 147 VAL VAL B . n 
B 1 117 LEU 117 148 148 LEU LEU B . n 
B 1 118 THR 118 149 149 THR THR B . n 
B 1 119 LYS 119 150 150 LYS LYS B . n 
B 1 120 ASP 120 151 151 ASP ASP B . n 
B 1 121 PRO 121 152 152 PRO PRO B . n 
B 1 122 ASP 122 153 153 ASP ASP B . n 
B 1 123 SER 123 154 154 SER SER B . n 
B 1 124 ALA 124 155 155 ALA ALA B . n 
B 1 125 LEU 125 156 156 LEU LEU B . n 
B 1 126 PHE 126 157 157 PHE PHE B . n 
B 1 127 VAL 127 158 158 VAL VAL B . n 
B 1 128 ILE 128 159 159 ILE ILE B . n 
B 1 129 ASN 129 160 160 ASN ASN B . n 
B 1 130 ARG 130 161 161 ARG ARG B . n 
B 1 131 VAL 131 162 162 VAL VAL B . n 
B 1 132 ASN 132 163 163 ASN ASN B . n 
B 1 133 GLN 133 164 164 GLN GLN B . n 
B 1 134 ALA 134 165 165 ALA ALA B . n 
B 1 135 ASN 135 166 166 ASN ASN B . n 
B 1 136 LEU 136 167 167 LEU LEU B . n 
B 1 137 ILE 137 168 168 ILE ILE B . n 
B 1 138 MET 138 169 169 MET MET B . n 
B 1 139 ALA 139 170 170 ALA ALA B . n 
B 1 140 ASP 140 171 171 ASP ASP B . n 
B 1 141 PHE 141 172 172 PHE PHE B . n 
B 1 142 GLU 142 173 173 GLU GLU B . n 
B 1 143 ILE 143 174 174 ILE ILE B . n 
B 1 144 GLY 144 175 175 GLY GLY B . n 
B 1 145 ILE 145 176 176 ILE ILE B . n 
B 1 146 ARG 146 177 177 ARG ARG B . n 
B 1 147 ALA 147 178 178 ALA ALA B . n 
B 1 148 ILE 148 179 179 ILE ILE B . n 
B 1 149 SER 149 180 180 SER SER B . n 
B 1 150 ILE 150 181 181 ILE ILE B . n 
B 1 151 ASP 151 182 182 ASP ASP B . n 
B 1 152 ASN 152 183 183 ASN ASN B . n 
B 1 153 ALA 153 184 184 ALA ALA B . n 
B 1 154 SER 154 185 185 SER SER B . n 
B 1 155 LEU 155 186 186 LEU LEU B . n 
B 1 156 ALA 156 187 187 ALA ALA B . n 
B 1 157 GLU 157 188 188 GLU GLU B . n 
B 1 158 ASN 158 189 189 ASN ASN B . n 
B 1 159 LEU 159 190 190 LEU LEU B . n 
B 1 160 LEU 160 191 191 LEU LEU B . n 
B 1 161 ILE 161 192 192 ILE ILE B . n 
B 1 162 GLN 162 193 193 GLN GLN B . n 
B 1 163 GLU 163 194 194 GLU GLU B . n 
B 1 164 VAL 164 195 195 VAL VAL B . n 
B 1 165 GLN 165 196 196 GLN GLN B . n 
B 1 166 PHE 166 197 197 PHE PHE B . n 
B 1 167 LEU 167 198 198 LEU LEU B . n 
B 1 168 GLN 168 199 199 GLN GLN B . n 
B 1 169 GLN 169 200 200 GLN GLN B . n 
B 1 170 CYS 170 201 201 CYS CYS B . n 
B 1 171 THR 171 202 202 THR THR B . n 
B 1 172 THR 172 203 203 THR THR B . n 
B 1 173 TYR 173 204 204 TYR TYR B . n 
B 1 174 SER 174 205 205 SER SER B . n 
B 1 175 MET 175 206 206 MET MET B . n 
B 1 176 GLY 176 207 207 GLY GLY B . n 
B 1 177 ILE 177 208 208 ILE ILE B . n 
B 1 178 PHE 178 209 209 PHE PHE B . n 
B 1 179 VAL 179 210 210 VAL VAL B . n 
B 1 180 ASP 180 211 211 ASP ASP B . n 
B 1 181 TRP 181 212 212 TRP TRP B . n 
B 1 182 GLU 182 213 213 GLU GLU B . n 
B 1 183 LEU 183 214 214 LEU LEU B . n 
B 1 184 TYR 184 215 215 TYR TYR B . n 
B 1 185 LYS 185 216 216 LYS LYS B . n 
B 1 186 GLN 186 217 217 GLN GLN B . n 
B 1 187 LEU 187 218 218 LEU LEU B . n 
B 1 188 GLU 188 219 219 GLU GLU B . n 
B 1 189 SER 189 220 220 SER SER B . n 
B 1 190 VAL 190 221 221 VAL VAL B . n 
B 1 191 ILE 191 222 222 ILE ILE B . n 
B 1 192 LYS 192 223 223 LYS LYS B . n 
B 1 193 ASP 193 224 224 ASP ASP B . n 
B 1 194 LEU 194 225 225 LEU LEU B . n 
B 1 195 GLU 195 226 226 GLU GLU B . n 
B 1 196 TYR 196 227 227 TYR TYR B . n 
B 1 197 ASN 197 228 228 ASN ASN B . n 
B 1 198 ILE 198 229 229 ILE ILE B . n 
B 1 199 TRP 199 230 230 TRP TRP B . n 
B 1 200 PRO 200 231 231 PRO PRO B . n 
B 1 201 ILE 201 232 232 ILE ILE B . n 
B 1 202 PRO 202 233 233 PRO PRO B . n 
B 1 203 GLY 203 234 234 GLY GLY B . n 
B 1 204 THR 204 235 235 THR THR B . n 
B 1 205 ARG 205 236 236 ARG ARG B . n 
B 1 206 ALA 206 237 237 ALA ALA B . n 
B 1 207 HIS 207 238 238 HIS HIS B . n 
B 1 208 LEU 208 239 239 LEU LEU B . n 
B 1 209 PHE 209 240 240 PHE PHE B . n 
B 1 210 PRO 210 241 241 PRO PRO B . n 
B 1 211 LYS 211 242 242 LYS LYS B . n 
B 1 212 VAL 212 243 243 VAL VAL B . n 
B 1 213 ALA 213 244 244 ALA ALA B . n 
B 1 214 HIS 214 245 245 HIS HIS B . n 
B 1 215 LEU 215 246 246 LEU LEU B . n 
B 1 216 LEU 216 247 247 LEU LEU B . n 
B 1 217 HIS 217 248 248 HIS HIS B . n 
B 1 218 GLN 218 249 249 GLN GLN B . n 
B 1 219 MET 219 250 250 MET MET B . n 
B 1 220 PRO 220 251 251 PRO PRO B . n 
B 1 221 TRP 221 252 252 TRP TRP B . n 
B 1 222 GLY 222 253 253 GLY GLY B . n 
B 1 223 GLU 223 254 254 GLU GLU B . n 
B 1 224 LYS 224 255 255 LYS LYS B . n 
B 1 225 ILE 225 256 256 ILE ILE B . n 
B 1 226 ALA 226 257 257 ALA ALA B . n 
B 1 227 SER 227 258 258 SER SER B . n 
B 1 228 VAL 228 259 259 VAL VAL B . n 
B 1 229 GLU 229 260 260 GLU GLU B . n 
B 1 230 ILE 230 261 261 ILE ILE B . n 
B 1 231 ALA 231 262 262 ALA ALA B . n 
B 1 232 THR 232 263 263 THR THR B . n 
B 1 233 GLU 233 264 264 GLU GLU B . n 
B 1 234 THR 234 265 265 THR THR B . n 
B 1 235 LEU 235 266 266 LEU LEU B . n 
B 1 236 GLU 236 267 267 GLU GLU B . n 
B 1 237 MET 237 268 268 MET MET B . n 
B 1 238 TYR 238 269 269 TYR TYR B . n 
B 1 239 ASN 239 270 270 ASN ASN B . n 
B 1 240 GLU 240 271 271 GLU GLU B . n 
B 1 241 PHE 241 272 272 PHE PHE B . n 
B 1 242 MET 242 273 273 MET MET B . n 
B 1 243 GLU 243 274 274 GLU GLU B . n 
B 1 244 ALA 244 275 275 ALA ALA B . n 
B 1 245 ALA 245 276 276 ALA ALA B . n 
B 1 246 ARG 246 277 277 ARG ARG B . n 
B 1 247 GLN 247 278 278 GLN GLN B . n 
B 1 248 GLU 248 279 279 GLU GLU B . n 
B 1 249 HIS 249 280 280 HIS HIS B . n 
B 1 250 MET 250 281 281 MET MET B . n 
B 1 251 CYS 251 282 282 CYS CYS B . n 
B 1 252 LEU 252 283 283 LEU LEU B . n 
B 1 253 MET 253 284 284 MET MET B . n 
B 1 254 HIS 254 285 285 HIS HIS B . n 
B 1 255 PHE 255 286 286 PHE PHE B . n 
B 1 256 LYS 256 287 287 LYS LYS B . n 
B 1 257 SER 257 288 288 SER SER B . n 
B 1 258 ASP 258 289 289 ASP ASP B . n 
B 1 259 ASP 259 290 290 ASP ASP B . n 
B 1 260 ASN 260 291 291 ASN ASN B . n 
B 1 261 VAL 261 292 292 VAL VAL B . n 
B 1 262 TYR 262 293 293 TYR TYR B . n 
B 1 263 ILE 263 294 294 ILE ILE B . n 
B 1 264 MET 264 295 295 MET MET B . n 
B 1 265 PHE 265 296 296 PHE PHE B . n 
B 1 266 GLY 266 297 297 GLY GLY B . n 
B 1 267 ASN 267 298 298 ASN ASN B . n 
B 1 268 LYS 268 299 299 LYS LYS B . n 
B 1 269 LEU 269 300 300 LEU LEU B . n 
B 1 270 ALA 270 301 301 ALA ALA B . n 
B 1 271 SER 271 302 302 SER SER B . n 
B 1 272 HIS 272 303 303 HIS HIS B . n 
B 1 273 PHE 273 304 304 PHE PHE B . n 
B 1 274 LYS 274 305 305 LYS LYS B . n 
B 1 275 GLU 275 306 306 GLU GLU B . n 
B 1 276 ASN 276 307 307 ASN ASN B . n 
B 1 277 GLY 277 308 308 GLY GLY B . n 
B 1 278 THR 278 309 309 THR THR B . n 
B 1 279 LEU 279 310 310 LEU LEU B . n 
B 1 280 PHE 280 311 311 PHE PHE B . n 
B 1 281 SER 281 312 312 SER SER B . n 
B 1 282 VAL 282 313 313 VAL VAL B . n 
B 1 283 PRO 283 314 314 PRO PRO B . n 
B 1 284 THR 284 315 315 THR THR B . n 
B 1 285 ASP 285 316 316 ASP ASP B . n 
B 1 286 ARG 286 317 317 ARG ARG B . n 
B 1 287 THR 287 318 318 THR THR B . n 
B 1 288 ASP 288 319 319 ASP ASP B . n 
B 1 289 ASP 289 320 320 ASP ASP B . n 
B 1 290 GLU 290 321 321 GLU GLU B . n 
B 1 291 PHE 291 322 322 PHE PHE B . n 
B 1 292 LEU 292 323 323 LEU LEU B . n 
B 1 293 ALA 293 324 324 ALA ALA B . n 
B 1 294 ASP 294 325 325 ASP ASP B . n 
B 1 295 LEU 295 326 326 LEU LEU B . n 
B 1 296 PRO 296 327 327 PRO PRO B . n 
B 1 297 ASN 297 328 328 ASN ASN B . n 
B 1 298 ARG 298 329 329 ARG ARG B . n 
B 1 299 ALA 299 330 330 ALA ALA B . n 
B 1 300 PHE 300 331 331 PHE PHE B . n 
B 1 301 VAL 301 332 332 VAL VAL B . n 
B 1 302 LEU 302 333 333 LEU LEU B . n 
B 1 303 MET 303 334 334 MET MET B . n 
B 1 304 GLU 304 335 335 GLU GLU B . n 
B 1 305 ASN 305 336 336 ASN ASN B . n 
B 1 306 GLU 306 337 337 GLU GLU B . n 
B 1 307 ILE 307 338 338 ILE ILE B . n 
B 1 308 ASP 308 339 339 ASP ASP B . n 
B 1 309 LEU 309 340 340 LEU LEU B . n 
B 1 310 SER 310 341 341 SER SER B . n 
B 1 311 THR 311 342 342 THR THR B . n 
B 1 312 ALA 312 343 343 ALA ALA B . n 
B 1 313 VAL 313 344 344 VAL VAL B . n 
B 1 314 GLU 314 345 345 GLU GLU B . n 
B 1 315 LEU 315 346 346 LEU LEU B . n 
B 1 316 ASP 316 347 347 ASP ASP B . n 
B 1 317 ALA 317 348 348 ALA ALA B . n 
B 1 318 THR 318 349 349 THR THR B . n 
B 1 319 PRO 319 350 350 PRO PRO B . n 
B 1 320 THR 320 351 351 THR THR B . n 
B 1 321 ALA 321 352 352 ALA ALA B . n 
B 1 322 LEU 322 353 353 LEU LEU B . n 
B 1 323 ASP 323 354 354 ASP ASP B . n 
B 1 324 GLU 324 355 355 GLU GLU B . n 
B 1 325 ILE 325 356 356 ILE ILE B . n 
B 1 326 LEU 326 357 357 LEU LEU B . n 
B 1 327 ILE 327 358 358 ILE ILE B . n 
B 1 328 GLY 328 359 359 GLY GLY B . n 
B 1 329 LYS 329 360 360 LYS LYS B . n 
B 1 330 SER 330 361 361 SER SER B . n 
B 1 331 VAL 331 362 362 VAL VAL B . n 
B 1 332 LEU 332 363 363 LEU LEU B . n 
B 1 333 PRO 333 364 364 PRO PRO B . n 
B 1 334 SER 334 365 365 SER SER B . n 
B 1 335 ARG 335 366 366 ARG ARG B . n 
B 1 336 VAL 336 367 367 VAL VAL B . n 
B 1 337 LEU 337 368 368 LEU LEU B . n 
B 1 338 SER 338 369 369 SER SER B . n 
B 1 339 PHE 339 370 370 PHE PHE B . n 
B 1 340 ALA 340 371 371 ALA ALA B . n 
B 1 341 GLY 341 372 372 GLY GLY B . n 
B 1 342 SER 342 373 373 SER SER B . n 
B 1 343 ILE 343 374 374 ILE ILE B . n 
B 1 344 ILE 344 375 375 ILE ILE B . n 
B 1 345 ASP 345 376 376 ASP ASP B . n 
B 1 346 LEU 346 377 377 LEU LEU B . n 
B 1 347 MET 347 378 378 MET MET B . n 
B 1 348 ASN 348 379 379 ASN ASN B . n 
B 1 349 TRP 349 380 380 TRP TRP B . n 
B 1 350 LEU 350 381 381 LEU LEU B . n 
B 1 351 ARG 351 382 382 ARG ARG B . n 
B 1 352 GLY 352 383 383 GLY GLY B . n 
B 1 353 SER 353 384 384 SER SER B . n 
B 1 354 LEU 354 385 385 LEU LEU B . n 
B 1 355 SER 355 386 386 SER SER B . n 
B 1 356 LYS 356 387 387 LYS LYS B . n 
B 1 357 HIS 357 388 388 HIS HIS B . n 
B 1 358 CYS 358 389 389 CYS CYS B . n 
B 1 359 LYS 359 390 390 LYS LYS B . n 
B 1 360 ARG 360 391 391 ARG ARG B . n 
B 1 361 GLY 361 392 ?   ?   ?   B . n 
B 1 362 GLU 362 393 ?   ?   ?   B . n 
B 1 363 GLU 363 394 ?   ?   ?   B . n 
B 1 364 HIS 364 395 ?   ?   ?   B . n 
B 1 365 ASP 365 396 396 ASP ASP B . n 
B 1 366 LEU 366 397 397 LEU LEU B . n 
B 1 367 TYR 367 398 398 TYR TYR B . n 
B 1 368 VAL 368 399 399 VAL VAL B . n 
B 1 369 LEU 369 400 400 LEU LEU B . n 
B 1 370 GLU 370 401 401 GLU GLU B . n 
B 1 371 SER 371 402 402 SER SER B . n 
B 1 372 CYS 372 403 403 CYS CYS B . n 
B 1 373 PHE 373 404 404 PHE PHE B . n 
B 1 374 ASN 374 405 405 ASN ASN B . n 
B 1 375 PHE 375 406 406 PHE PHE B . n 
B 1 376 LEU 376 407 407 LEU LEU B . n 
B 1 377 ASN 377 408 408 ASN ASN B . n 
B 1 378 PHE 378 409 409 PHE PHE B . n 
B 1 379 ILE 379 410 410 ILE ILE B . n 
B 1 380 GLU 380 411 411 GLU GLU B . n 
B 1 381 ASP 381 412 412 ASP ASP B . n 
B 1 382 TRP 382 413 413 TRP TRP B . n 
B 1 383 ARG 383 414 414 ARG ARG B . n 
B 1 384 THR 384 415 415 THR THR B . n 
B 1 385 SER 385 416 416 SER SER B . n 
B 1 386 GLU 386 417 417 GLU GLU B . n 
B 1 387 TYR 387 418 418 TYR TYR B . n 
B 1 388 ARG 388 419 419 ARG ARG B . n 
B 1 389 GLN 389 420 420 GLN GLN B . n 
B 1 390 ALA 390 421 421 ALA ALA B . n 
B 1 391 HIS 391 422 422 HIS HIS B . n 
B 1 392 ASP 392 423 423 ASP ASP B . n 
B 1 393 THR 393 424 424 THR THR B . n 
B 1 394 ALA 394 425 425 ALA ALA B . n 
B 1 395 GLU 395 426 426 GLU GLU B . n 
B 1 396 ILE 396 427 427 ILE ILE B . n 
B 1 397 LEU 397 428 428 LEU LEU B . n 
B 1 398 SER 398 429 429 SER SER B . n 
B 1 399 LEU 399 430 430 LEU LEU B . n 
B 1 400 LEU 400 431 431 LEU LEU B . n 
B 1 401 LEU 401 432 432 LEU LEU B . n 
B 1 402 MET 402 433 433 MET MET B . n 
B 1 403 ARG 403 434 434 ARG ARG B . n 
B 1 404 LYS 404 435 435 LYS LYS B . n 
B 1 405 LEU 405 436 436 LEU LEU B . n 
B 1 406 GLY 406 437 437 GLY GLY B . n 
B 1 407 THR 407 438 438 THR THR B . n 
B 1 408 ALA 408 439 439 ALA ALA B . n 
B 1 409 MET 409 440 440 MET MET B . n 
B 1 410 ASN 410 441 441 ASN ASN B . n 
B 1 411 PHE 411 442 442 PHE PHE B . n 
B 1 412 GLN 412 443 443 GLN GLN B . n 
B 1 413 MET 413 444 444 MET MET B . n 
B 1 414 TYR 414 445 445 TYR TYR B . n 
B 1 415 GLN 415 446 446 GLN GLN B . n 
B 1 416 LYS 416 447 447 LYS LYS B . n 
B 1 417 LYS 417 448 448 LYS LYS B . n 
B 1 418 VAL 418 449 449 VAL VAL B . n 
B 1 419 LEU 419 450 450 LEU LEU B . n 
B 1 420 THR 420 451 ?   ?   ?   B . n 
B 1 421 LEU 421 452 ?   ?   ?   B . n 
B 1 422 ASP 422 453 ?   ?   ?   B . n 
B 1 423 LYS 423 454 ?   ?   ?   B . n 
B 1 424 ILE 424 455 ?   ?   ?   B . n 
B 1 425 THR 425 456 ?   ?   ?   B . n 
B 1 426 GLY 426 457 ?   ?   ?   B . n 
B 1 427 GLU 427 458 ?   ?   ?   B . n 
B 1 428 SER 428 459 ?   ?   ?   B . n 
B 1 429 ARG 429 460 ?   ?   ?   B . n 
B 1 430 THR 430 461 461 THR THR B . n 
B 1 431 GLU 431 462 462 GLU GLU B . n 
B 1 432 LEU 432 463 463 LEU LEU B . n 
B 1 433 ARG 433 464 464 ARG ARG B . n 
B 1 434 GLU 434 465 465 GLU GLU B . n 
B 1 435 ILE 435 466 466 ILE ILE B . n 
B 1 436 ALA 436 467 467 ALA ALA B . n 
B 1 437 SER 437 468 468 SER SER B . n 
B 1 438 GLN 438 469 469 GLN GLN B . n 
B 1 439 ASN 439 470 470 ASN ASN B . n 
B 1 440 PHE 440 471 471 PHE PHE B . n 
B 1 441 VAL 441 472 472 VAL VAL B . n 
B 1 442 THR 442 473 473 THR THR B . n 
B 1 443 ASN 443 474 474 ASN ASN B . n 
B 1 444 VAL 444 475 475 VAL VAL B . n 
B 1 445 THR 445 476 476 THR THR B . n 
B 1 446 THR 446 477 477 THR THR B . n 
B 1 447 TYR 447 478 478 TYR TYR B . n 
B 1 448 TYR 448 479 479 TYR TYR B . n 
B 1 449 HIS 449 480 480 HIS HIS B . n 
B 1 450 TYR 450 481 481 TYR TYR B . n 
B 1 451 ASN 451 482 482 ASN ASN B . n 
B 1 452 ARG 452 483 483 ARG ARG B . n 
B 1 453 ASP 453 484 484 ASP ASP B . n 
B 1 454 ASN 454 485 485 ASN ASN B . n 
B 1 455 HIS 455 486 486 HIS HIS B . n 
B 1 456 THR 456 487 487 THR THR B . n 
B 1 457 SER 457 488 488 SER SER B . n 
B 1 458 LEU 458 489 489 LEU LEU B . n 
B 1 459 GLU 459 490 490 GLU GLU B . n 
B 1 460 LEU 460 491 491 LEU LEU B . n 
B 1 461 LYS 461 492 492 LYS LYS B . n 
B 1 462 THR 462 493 493 THR THR B . n 
B 1 463 LYS 463 494 494 LYS LYS B . n 
B 1 464 PHE 464 495 495 PHE PHE B . n 
B 1 465 GLY 465 496 496 GLY GLY B . n 
B 1 466 GLN 466 497 497 GLN GLN B . n 
B 1 467 VAL 467 498 498 VAL VAL B . n 
B 1 468 PHE 468 499 499 PHE PHE B . n 
B 1 469 ASN 469 500 500 ASN ASN B . n 
B 1 470 CYS 470 501 501 CYS CYS B . n 
B 1 471 GLN 471 502 ?   ?   ?   B . n 
B 1 472 TYR 472 503 ?   ?   ?   B . n 
B 1 473 SER 473 504 ?   ?   ?   B . n 
B 1 474 ALA 474 505 ?   ?   ?   B . n 
B 1 475 GLY 475 506 ?   ?   ?   B . n 
B 1 476 ASP 476 507 ?   ?   ?   B . n 
B 1 477 ASN 477 508 ?   ?   ?   B . n 
B 1 478 ARG 478 509 ?   ?   ?   B . n 
B 1 479 ARG 479 510 ?   ?   ?   B . n 
B 1 480 TYR 480 511 ?   ?   ?   B . n 
B 1 481 PRO 481 512 ?   ?   ?   B . n 
B 1 482 PHE 482 513 ?   ?   ?   B . n 
B 1 483 LEU 483 514 ?   ?   ?   B . n 
B 1 484 PHE 484 515 ?   ?   ?   B . n 
B 1 485 ASP 485 516 ?   ?   ?   B . n 
B 1 486 GLY 486 517 ?   ?   ?   B . n 
B 1 487 GLU 487 518 ?   ?   ?   B . n 
B 1 488 SER 488 519 ?   ?   ?   B . n 
B 1 489 VAL 489 520 ?   ?   ?   B . n 
B 1 490 MET 490 521 521 MET MET B . n 
B 1 491 PHE 491 522 522 PHE PHE B . n 
B 1 492 TRP 492 523 523 TRP TRP B . n 
B 1 493 ARG 493 524 524 ARG ARG B . n 
B 1 494 ILE 494 525 525 ILE ILE B . n 
B 1 495 LYS 495 526 526 LYS LYS B . n 
B 1 496 MET 496 527 527 MET MET B . n 
B 1 497 ASP 497 528 528 ASP ASP B . n 
B 1 498 THR 498 529 529 THR THR B . n 
B 1 499 TRP 499 530 ?   ?   ?   B . n 
B 1 500 HIS 500 531 ?   ?   ?   B . n 
B 1 501 HIS 501 532 ?   ?   ?   B . n 
B 1 502 HIS 502 533 ?   ?   ?   B . n 
B 1 503 HIS 503 534 ?   ?   ?   B . n 
B 1 504 HIS 504 535 ?   ?   ?   B . n 
B 1 505 HIS 505 536 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        NAG 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   NAG 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 NAG 1 601 1531 NAG NAG A . 
D 2 NAG 1 602 1532 NAG NAG A . 
E 2 NAG 1 603 1533 NAG NAG A . 
F 2 NAG 1 601 1531 NAG NAG B . 
G 2 NAG 1 602 1532 NAG NAG B . 
H 2 NAG 1 603 1533 NAG NAG B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A HIS 303 ? CG  ? A HIS 272 CG  
2  1 Y 1 A HIS 303 ? ND1 ? A HIS 272 ND1 
3  1 Y 1 A HIS 303 ? CD2 ? A HIS 272 CD2 
4  1 Y 1 A HIS 303 ? CE1 ? A HIS 272 CE1 
5  1 Y 1 A HIS 303 ? NE2 ? A HIS 272 NE2 
6  1 Y 1 A LYS 305 ? CG  ? A LYS 274 CG  
7  1 Y 1 A LYS 305 ? CD  ? A LYS 274 CD  
8  1 Y 1 A LYS 305 ? CE  ? A LYS 274 CE  
9  1 Y 1 A LYS 305 ? NZ  ? A LYS 274 NZ  
10 1 Y 1 A PHE 404 ? CG  ? A PHE 373 CG  
11 1 Y 1 A PHE 404 ? CD1 ? A PHE 373 CD1 
12 1 Y 1 A PHE 404 ? CD2 ? A PHE 373 CD2 
13 1 Y 1 A PHE 404 ? CE1 ? A PHE 373 CE1 
14 1 Y 1 A PHE 404 ? CE2 ? A PHE 373 CE2 
15 1 Y 1 A PHE 404 ? CZ  ? A PHE 373 CZ  
16 1 Y 1 B HIS 303 ? CG  ? B HIS 272 CG  
17 1 Y 1 B HIS 303 ? ND1 ? B HIS 272 ND1 
18 1 Y 1 B HIS 303 ? CD2 ? B HIS 272 CD2 
19 1 Y 1 B HIS 303 ? CE1 ? B HIS 272 CE1 
20 1 Y 1 B HIS 303 ? NE2 ? B HIS 272 NE2 
21 1 Y 1 B LYS 305 ? CG  ? B LYS 274 CG  
22 1 Y 1 B LYS 305 ? CD  ? B LYS 274 CD  
23 1 Y 1 B LYS 305 ? CE  ? B LYS 274 CE  
24 1 Y 1 B LYS 305 ? NZ  ? B LYS 274 NZ  
25 1 Y 1 B PHE 404 ? CG  ? B PHE 373 CG  
26 1 Y 1 B PHE 404 ? CD1 ? B PHE 373 CD1 
27 1 Y 1 B PHE 404 ? CD2 ? B PHE 373 CD2 
28 1 Y 1 B PHE 404 ? CE1 ? B PHE 373 CE1 
29 1 Y 1 B PHE 404 ? CE2 ? B PHE 373 CE2 
30 1 Y 1 B PHE 404 ? CZ  ? B PHE 373 CZ  
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BFR 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BFR 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BFR 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 9BFR 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.006 ? 6382 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 1.017 ? 8636 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 7.467 ? 936  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.060 ? 1012 ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.008 ? 1086 ? f_plane_restr      ? ? 
# 
_struct.entry_id                     9BFR 
_struct.title                        'Cryo-EM structure of Bride of Sevenless extracellular domain (dimer, Sevenless-bound form)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BFR 
_struct_keywords.text            
;bride of sevenless, boss, GPCR, G-protein coupled receptor, drosophila, eye development, vision, photoreceptor, glucose metabolism, SIGNALING PROTEIN
;
_struct_keywords.pdbx_keywords   'SIGNALING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
E N N 2 ? 
F N N 2 ? 
G N N 2 ? 
H N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    BOSS_DROME 
_struct_ref.pdbx_db_accession          P22815 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;CHGADLTSPTKKSAPLRITKPQPTSQQAKPISITTRAPTTVASTTDDEVSSSVDGQLAPLISSTTEGPSSGTTASLVPEI
CLNGLQLTVNSADEGTVIRKQEEFVKILEGDVVLSVLTKDPDSALFVINRVNQANLIMADFEIGIRAISIDNASLAENLL
IQEVQFLQQCTTYSMGIFVDWELYKQLESVIKDLEYNIWPIPGTRAHLFPKVAHLLHQMPWGEKIASVEIATETLEMYNE
FMEAARQEHMCLMHFKSDDNVYIMFGNKLASHFKENGTLFSVPTDRTDDEFLADLPNRAFVLMENEIDLSTAVELDATPT
ALDEILIGKSVLPSRVLSFAGSIIDLMNWLRGSLSKHCKRGEEHDLYVLESCFNFLNFIEDWRTSEYRQAHDTAEILSLL
LMRKLGTAMNFQMYQKKVLTLDKITGESRTELREIASQNFVTNVTTYYHYNRDNHTSLELKTKFGQVFNCQYSAGDNRRY
PFLFDGESVMFWRIKMDTW
;
_struct_ref.pdbx_align_begin           32 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9BFR A 1 ? 499 ? P22815 32 ? 530 ? 32 530 
2 1 9BFR B 1 ? 499 ? P22815 32 ? 530 ? 32 530 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9BFR HIS A 500 ? UNP P22815 ? ? 'expression tag' 531 1  
1 9BFR HIS A 501 ? UNP P22815 ? ? 'expression tag' 532 2  
1 9BFR HIS A 502 ? UNP P22815 ? ? 'expression tag' 533 3  
1 9BFR HIS A 503 ? UNP P22815 ? ? 'expression tag' 534 4  
1 9BFR HIS A 504 ? UNP P22815 ? ? 'expression tag' 535 5  
1 9BFR HIS A 505 ? UNP P22815 ? ? 'expression tag' 536 6  
2 9BFR HIS B 500 ? UNP P22815 ? ? 'expression tag' 531 7  
2 9BFR HIS B 501 ? UNP P22815 ? ? 'expression tag' 532 8  
2 9BFR HIS B 502 ? UNP P22815 ? ? 'expression tag' 533 9  
2 9BFR HIS B 503 ? UNP P22815 ? ? 'expression tag' 534 10 
2 9BFR HIS B 504 ? UNP P22815 ? ? 'expression tag' 535 11 
2 9BFR HIS B 505 ? UNP P22815 ? ? 'expression tag' 536 12 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PRO A 78  ? GLY A 84  ? PRO A 109 GLY A 115 1 ? 7  
HELX_P HELX_P2  AA2 LYS A 100 ? PHE A 104 ? LYS A 131 PHE A 135 5 ? 5  
HELX_P HELX_P3  AA3 PRO A 121 ? ASN A 135 ? PRO A 152 ASN A 166 1 ? 15 
HELX_P HELX_P4  AA4 LEU A 155 ? GLN A 168 ? LEU A 186 GLN A 199 1 ? 14 
HELX_P HELX_P5  AA5 ASP A 180 ? LEU A 187 ? ASP A 211 LEU A 218 1 ? 8  
HELX_P HELX_P6  AA6 LEU A 187 ? GLU A 195 ? LEU A 218 GLU A 226 1 ? 9  
HELX_P HELX_P7  AA7 THR A 204 ? GLN A 218 ? THR A 235 GLN A 249 1 ? 15 
HELX_P HELX_P8  AA8 LEU A 235 ? GLU A 248 ? LEU A 266 GLU A 279 1 ? 14 
HELX_P HELX_P9  AA9 LEU A 332 ? SER A 338 ? LEU A 363 SER A 369 1 ? 7  
HELX_P HELX_P10 AB1 PHE A 339 ? LEU A 354 ? PHE A 370 LEU A 385 1 ? 16 
HELX_P HELX_P11 AB2 VAL A 368 ? CYS A 372 ? VAL A 399 CYS A 403 5 ? 5  
HELX_P HELX_P12 AB3 PHE A 378 ? ARG A 383 ? PHE A 409 ARG A 414 5 ? 6  
HELX_P HELX_P13 AB4 ASP A 392 ? LEU A 400 ? ASP A 423 LEU A 431 1 ? 9  
HELX_P HELX_P14 AB5 MET A 402 ? THR A 407 ? MET A 433 THR A 438 5 ? 6  
HELX_P HELX_P15 AB6 PHE A 464 ? PHE A 468 ? PHE A 495 PHE A 499 1 ? 5  
HELX_P HELX_P16 AB7 PRO B 78  ? GLY B 84  ? PRO B 109 GLY B 115 1 ? 7  
HELX_P HELX_P17 AB8 LYS B 100 ? PHE B 104 ? LYS B 131 PHE B 135 1 ? 5  
HELX_P HELX_P18 AB9 ASP B 120 ? ASN B 135 ? ASP B 151 ASN B 166 1 ? 16 
HELX_P HELX_P19 AC1 LEU B 155 ? GLN B 168 ? LEU B 186 GLN B 199 1 ? 14 
HELX_P HELX_P20 AC2 ASP B 180 ? LEU B 187 ? ASP B 211 LEU B 218 1 ? 8  
HELX_P HELX_P21 AC3 LEU B 187 ? GLU B 195 ? LEU B 218 GLU B 226 1 ? 9  
HELX_P HELX_P22 AC4 THR B 204 ? GLN B 218 ? THR B 235 GLN B 249 1 ? 15 
HELX_P HELX_P23 AC5 LEU B 235 ? GLU B 248 ? LEU B 266 GLU B 279 1 ? 14 
HELX_P HELX_P24 AC6 LEU B 332 ? LEU B 354 ? LEU B 363 LEU B 385 1 ? 23 
HELX_P HELX_P25 AC7 VAL B 368 ? CYS B 372 ? VAL B 399 CYS B 403 5 ? 5  
HELX_P HELX_P26 AC8 PHE B 378 ? ARG B 383 ? PHE B 409 ARG B 414 5 ? 6  
HELX_P HELX_P27 AC9 ASP B 392 ? LEU B 400 ? ASP B 423 LEU B 431 1 ? 9  
HELX_P HELX_P28 AD1 MET B 402 ? ALA B 408 ? MET B 433 ALA B 439 5 ? 7  
HELX_P HELX_P29 AD2 PHE B 464 ? PHE B 468 ? PHE B 495 PHE B 499 1 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ?   ? A CYS 81  SG  ? ? ? 1_555 A CYS 170 SG ? ? A CYS 112 A CYS 201 1_555 ? ? ? ? ? ? ? 2.030 ? ?               
disulf2 disulf ?   ? A CYS 251 SG  ? ? ? 1_555 A CYS 470 SG ? ? A CYS 282 A CYS 501 1_555 ? ? ? ? ? ? ? 2.035 ? ?               
disulf3 disulf ?   ? A CYS 358 SG  ? ? ? 1_555 A CYS 372 SG ? ? A CYS 389 A CYS 403 1_555 ? ? ? ? ? ? ? 2.029 ? ?               
disulf4 disulf ?   ? B CYS 81  SG  ? ? ? 1_555 B CYS 170 SG ? ? B CYS 112 B CYS 201 1_555 ? ? ? ? ? ? ? 2.029 ? ?               
disulf5 disulf ?   ? B CYS 251 SG  ? ? ? 1_555 B CYS 470 SG ? ? B CYS 282 B CYS 501 1_555 ? ? ? ? ? ? ? 2.035 ? ?               
disulf6 disulf ?   ? B CYS 358 SG  ? ? ? 1_555 B CYS 372 SG ? ? B CYS 389 B CYS 403 1_555 ? ? ? ? ? ? ? 2.029 ? ?               
covale1 covale one ? A ASN 152 ND2 ? ? ? 1_555 C NAG .   C1 ? ? A ASN 183 A NAG 601 1_555 ? ? ? ? ? ? ? 1.441 ? N-Glycosylation 
covale2 covale one ? A ASN 443 ND2 ? ? ? 1_555 D NAG .   C1 ? ? A ASN 474 A NAG 602 1_555 ? ? ? ? ? ? ? 1.437 ? N-Glycosylation 
covale3 covale one ? A ASN 454 ND2 ? ? ? 1_555 E NAG .   C1 ? ? A ASN 485 A NAG 603 1_555 ? ? ? ? ? ? ? 1.432 ? N-Glycosylation 
covale4 covale one ? B ASN 152 ND2 ? ? ? 1_555 F NAG .   C1 ? ? B ASN 183 B NAG 601 1_555 ? ? ? ? ? ? ? 1.441 ? N-Glycosylation 
covale5 covale one ? B ASN 443 ND2 ? ? ? 1_555 G NAG .   C1 ? ? B ASN 474 B NAG 602 1_555 ? ? ? ? ? ? ? 1.437 ? N-Glycosylation 
covale6 covale one ? B ASN 454 ND2 ? ? ? 1_555 H NAG .   C1 ? ? B ASN 485 B NAG 603 1_555 ? ? ? ? ? ? ? 1.432 ? N-Glycosylation 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1  NAG C .   ? ASN A 152 ? NAG A 601 ? 1_555 ASN A 183 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2  NAG D .   ? ASN A 443 ? NAG A 602 ? 1_555 ASN A 474 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
3  NAG E .   ? ASN A 454 ? NAG A 603 ? 1_555 ASN A 485 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
4  NAG F .   ? ASN B 152 ? NAG B 601 ? 1_555 ASN B 183 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
5  NAG G .   ? ASN B 443 ? NAG B 602 ? 1_555 ASN B 474 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
6  NAG H .   ? ASN B 454 ? NAG B 603 ? 1_555 ASN B 485 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
7  CYS A 81  ? CYS A 170 ? CYS A 112 ? 1_555 CYS A 201 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
8  CYS A 251 ? CYS A 470 ? CYS A 282 ? 1_555 CYS A 501 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
9  CYS A 358 ? CYS A 372 ? CYS A 389 ? 1_555 CYS A 403 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
10 CYS B 81  ? CYS B 170 ? CYS B 112 ? 1_555 CYS B 201 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
11 CYS B 251 ? CYS B 470 ? CYS B 282 ? 1_555 CYS B 501 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
12 CYS B 358 ? CYS B 372 ? CYS B 389 ? 1_555 CYS B 403 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2  ? 
AA2 ? 5  ? 
AA3 ? 2  ? 
AA4 ? 16 ? 
AA5 ? 2  ? 
AA6 ? 2  ? 
AA7 ? 5  ? 
AA8 ? 2  ? 
AA9 ? 2  ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1  2  ? anti-parallel 
AA2 1  2  ? anti-parallel 
AA2 2  3  ? parallel      
AA2 3  4  ? parallel      
AA2 4  5  ? parallel      
AA3 1  2  ? anti-parallel 
AA4 1  2  ? anti-parallel 
AA4 2  3  ? anti-parallel 
AA4 3  4  ? anti-parallel 
AA4 4  5  ? parallel      
AA4 5  6  ? parallel      
AA4 6  7  ? parallel      
AA4 7  8  ? anti-parallel 
AA4 8  9  ? anti-parallel 
AA4 9  10 ? anti-parallel 
AA4 10 11 ? parallel      
AA4 11 12 ? parallel      
AA4 12 13 ? parallel      
AA4 13 14 ? anti-parallel 
AA4 14 15 ? anti-parallel 
AA4 15 16 ? anti-parallel 
AA5 1  2  ? anti-parallel 
AA6 1  2  ? anti-parallel 
AA7 1  2  ? anti-parallel 
AA7 2  3  ? parallel      
AA7 3  4  ? parallel      
AA7 4  5  ? parallel      
AA8 1  2  ? anti-parallel 
AA9 1  2  ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1  LEU A 87  ? THR A 88  ? LEU A 118 THR A 119 
AA1 2  ILE A 98  ? ARG A 99  ? ILE A 129 ARG A 130 
AA2 1  LYS A 106 ? LEU A 108 ? LYS A 137 LEU A 139 
AA2 2  ILE A 145 ? SER A 149 ? ILE A 176 SER A 180 
AA2 3  SER A 115 ? THR A 118 ? SER A 146 THR A 149 
AA2 4  ILE A 177 ? VAL A 179 ? ILE A 208 VAL A 210 
AA2 5  ILE A 198 ? PRO A 200 ? ILE A 229 PRO A 231 
AA3 1  PRO A 220 ? TRP A 221 ? PRO A 251 TRP A 252 
AA3 2  THR A 462 ? LYS A 463 ? THR A 493 LYS A 494 
AA4 1  THR A 445 ? TYR A 447 ? THR A 476 TYR A 478 
AA4 2  GLU A 431 ? ASN A 439 ? GLU A 462 ASN A 470 
AA4 3  ASN A 410 ? LYS A 417 ? ASN A 441 LYS A 448 
AA4 4  ALA A 299 ? GLU A 304 ? ALA A 330 GLU A 335 
AA4 5  THR A 278 ? VAL A 282 ? THR A 309 VAL A 313 
AA4 6  ASN A 260 ? PHE A 265 ? ASN A 291 PHE A 296 
AA4 7  SER A 227 ? THR A 232 ? SER A 258 THR A 263 
AA4 8  PHE B 491 ? ASP B 497 ? PHE B 522 ASP B 528 
AA4 9  PHE A 491 ? ASP A 497 ? PHE A 522 ASP A 528 
AA4 10 SER B 227 ? THR B 232 ? SER B 258 THR B 263 
AA4 11 ASN B 260 ? PHE B 265 ? ASN B 291 PHE B 296 
AA4 12 THR B 278 ? VAL B 282 ? THR B 309 VAL B 313 
AA4 13 ALA B 299 ? GLU B 304 ? ALA B 330 GLU B 335 
AA4 14 ASN B 410 ? LYS B 417 ? ASN B 441 LYS B 448 
AA4 15 GLU B 431 ? ASN B 439 ? GLU B 462 ASN B 470 
AA4 16 THR B 445 ? TYR B 447 ? THR B 476 TYR B 478 
AA5 1  ILE A 307 ? ASP A 308 ? ILE A 338 ASP A 339 
AA5 2  SER A 330 ? VAL A 331 ? SER A 361 VAL A 362 
AA6 1  LEU B 87  ? THR B 88  ? LEU B 118 THR B 119 
AA6 2  ILE B 98  ? ARG B 99  ? ILE B 129 ARG B 130 
AA7 1  VAL B 105 ? LEU B 108 ? VAL B 136 LEU B 139 
AA7 2  ILE B 145 ? SER B 149 ? ILE B 176 SER B 180 
AA7 3  SER B 115 ? THR B 118 ? SER B 146 THR B 149 
AA7 4  ILE B 177 ? VAL B 179 ? ILE B 208 VAL B 210 
AA7 5  ILE B 198 ? PRO B 200 ? ILE B 229 PRO B 231 
AA8 1  PRO B 220 ? TRP B 221 ? PRO B 251 TRP B 252 
AA8 2  THR B 462 ? LYS B 463 ? THR B 493 LYS B 494 
AA9 1  ILE B 307 ? ASP B 308 ? ILE B 338 ASP B 339 
AA9 2  SER B 330 ? VAL B 331 ? SER B 361 VAL B 362 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1  2  N LEU A 87  ? N LEU A 118 O ARG A 99  ? O ARG A 130 
AA2 1  2  N LEU A 108 ? N LEU A 139 O ILE A 145 ? O ILE A 176 
AA2 2  3  O ILE A 148 ? O ILE A 179 N VAL A 116 ? N VAL A 147 
AA2 3  4  N LEU A 117 ? N LEU A 148 O PHE A 178 ? O PHE A 209 
AA2 4  5  N VAL A 179 ? N VAL A 210 O TRP A 199 ? O TRP A 230 
AA3 1  2  N TRP A 221 ? N TRP A 252 O THR A 462 ? O THR A 493 
AA4 1  2  O THR A 446 ? O THR A 477 N SER A 437 ? N SER A 468 
AA4 2  3  O ILE A 435 ? O ILE A 466 N MET A 413 ? N MET A 444 
AA4 3  4  O TYR A 414 ? O TYR A 445 N VAL A 301 ? N VAL A 332 
AA4 4  5  O PHE A 300 ? O PHE A 331 N LEU A 279 ? N LEU A 310 
AA4 5  6  O VAL A 282 ? O VAL A 313 N MET A 264 ? N MET A 295 
AA4 6  7  O VAL A 261 ? O VAL A 292 N SER A 227 ? N SER A 258 
AA4 7  8  N ILE A 230 ? N ILE A 261 O ILE B 494 ? O ILE B 525 
AA4 8  9  O PHE B 491 ? O PHE B 522 N ASP A 497 ? N ASP A 528 
AA4 9  10 N ILE A 494 ? N ILE A 525 O ILE B 230 ? O ILE B 261 
AA4 10 11 N SER B 227 ? N SER B 258 O VAL B 261 ? O VAL B 292 
AA4 11 12 N MET B 264 ? N MET B 295 O VAL B 282 ? O VAL B 313 
AA4 12 13 N LEU B 279 ? N LEU B 310 O PHE B 300 ? O PHE B 331 
AA4 13 14 N VAL B 301 ? N VAL B 332 O TYR B 414 ? O TYR B 445 
AA4 14 15 N MET B 413 ? N MET B 444 O ILE B 435 ? O ILE B 466 
AA4 15 16 N SER B 437 ? N SER B 468 O THR B 446 ? O THR B 477 
AA5 1  2  N ILE A 307 ? N ILE A 338 O VAL A 331 ? O VAL A 362 
AA6 1  2  N LEU B 87  ? N LEU B 118 O ARG B 99  ? O ARG B 130 
AA7 1  2  N LEU B 108 ? N LEU B 139 O ILE B 145 ? O ILE B 176 
AA7 2  3  O ILE B 148 ? O ILE B 179 N VAL B 116 ? N VAL B 147 
AA7 3  4  N LEU B 117 ? N LEU B 148 O PHE B 178 ? O PHE B 209 
AA7 4  5  N VAL B 179 ? N VAL B 210 O TRP B 199 ? O TRP B 230 
AA8 1  2  N TRP B 221 ? N TRP B 252 O THR B 462 ? O THR B 493 
AA9 1  2  N ILE B 307 ? N ILE B 338 O VAL B 331 ? O VAL B 362 
# 
_pdbx_entry_details.entry_id                   9BFR 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 LEU A 218 ? ? -107.07 41.42 
2 1 GLU A 254 ? ? -97.42  33.49 
3 1 MET A 433 ? ? -140.81 40.63 
4 1 PHE A 499 ? ? -99.52  36.44 
5 1 LEU B 218 ? ? -107.11 41.32 
6 1 GLU B 254 ? ? -97.22  33.46 
7 1 MET B 433 ? ? -140.24 39.65 
8 1 PHE B 499 ? ? -99.44  36.32 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9BFR 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9BFR 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.19 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               187282 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            6.6 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               'MULTIPLE SOURCES' 
_em_entity_assembly.type                 'ORGANELLE OR CELLULAR COMPONENT' 
_em_entity_assembly.name                 'Bride of Sevenless extracellular domain' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        9BFR 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               OTHER 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    GOLD 
_em_sample_support.grid_mesh_size   ? 
_em_sample_support.grid_type        ? 
_em_sample_support.details          ? 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_vitrification.entry_id              9BFR 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9BFR 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
_em_single_particle_entity.entry_id              9BFR 
_em_single_particle_entity.id                    1 
_em_single_particle_entity.image_processing_id   1 
_em_single_particle_entity.point_symmetry        C2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A CYS 32  ? A CYS 1   
2   1 Y 1 A HIS 33  ? A HIS 2   
3   1 Y 1 A GLY 34  ? A GLY 3   
4   1 Y 1 A ALA 35  ? A ALA 4   
5   1 Y 1 A ASP 36  ? A ASP 5   
6   1 Y 1 A LEU 37  ? A LEU 6   
7   1 Y 1 A THR 38  ? A THR 7   
8   1 Y 1 A SER 39  ? A SER 8   
9   1 Y 1 A PRO 40  ? A PRO 9   
10  1 Y 1 A THR 41  ? A THR 10  
11  1 Y 1 A LYS 42  ? A LYS 11  
12  1 Y 1 A LYS 43  ? A LYS 12  
13  1 Y 1 A SER 44  ? A SER 13  
14  1 Y 1 A ALA 45  ? A ALA 14  
15  1 Y 1 A PRO 46  ? A PRO 15  
16  1 Y 1 A LEU 47  ? A LEU 16  
17  1 Y 1 A ARG 48  ? A ARG 17  
18  1 Y 1 A ILE 49  ? A ILE 18  
19  1 Y 1 A THR 50  ? A THR 19  
20  1 Y 1 A LYS 51  ? A LYS 20  
21  1 Y 1 A PRO 52  ? A PRO 21  
22  1 Y 1 A GLN 53  ? A GLN 22  
23  1 Y 1 A PRO 54  ? A PRO 23  
24  1 Y 1 A THR 55  ? A THR 24  
25  1 Y 1 A SER 56  ? A SER 25  
26  1 Y 1 A GLN 57  ? A GLN 26  
27  1 Y 1 A GLN 58  ? A GLN 27  
28  1 Y 1 A ALA 59  ? A ALA 28  
29  1 Y 1 A LYS 60  ? A LYS 29  
30  1 Y 1 A PRO 61  ? A PRO 30  
31  1 Y 1 A ILE 62  ? A ILE 31  
32  1 Y 1 A SER 63  ? A SER 32  
33  1 Y 1 A ILE 64  ? A ILE 33  
34  1 Y 1 A THR 65  ? A THR 34  
35  1 Y 1 A THR 66  ? A THR 35  
36  1 Y 1 A ARG 67  ? A ARG 36  
37  1 Y 1 A ALA 68  ? A ALA 37  
38  1 Y 1 A PRO 69  ? A PRO 38  
39  1 Y 1 A THR 70  ? A THR 39  
40  1 Y 1 A THR 71  ? A THR 40  
41  1 Y 1 A VAL 72  ? A VAL 41  
42  1 Y 1 A ALA 73  ? A ALA 42  
43  1 Y 1 A SER 74  ? A SER 43  
44  1 Y 1 A THR 75  ? A THR 44  
45  1 Y 1 A THR 76  ? A THR 45  
46  1 Y 1 A ASP 77  ? A ASP 46  
47  1 Y 1 A ASP 78  ? A ASP 47  
48  1 Y 1 A GLU 79  ? A GLU 48  
49  1 Y 1 A VAL 80  ? A VAL 49  
50  1 Y 1 A SER 81  ? A SER 50  
51  1 Y 1 A SER 82  ? A SER 51  
52  1 Y 1 A SER 83  ? A SER 52  
53  1 Y 1 A VAL 84  ? A VAL 53  
54  1 Y 1 A ASP 85  ? A ASP 54  
55  1 Y 1 A GLY 86  ? A GLY 55  
56  1 Y 1 A GLN 87  ? A GLN 56  
57  1 Y 1 A LEU 88  ? A LEU 57  
58  1 Y 1 A ALA 89  ? A ALA 58  
59  1 Y 1 A PRO 90  ? A PRO 59  
60  1 Y 1 A LEU 91  ? A LEU 60  
61  1 Y 1 A ILE 92  ? A ILE 61  
62  1 Y 1 A SER 93  ? A SER 62  
63  1 Y 1 A SER 94  ? A SER 63  
64  1 Y 1 A THR 95  ? A THR 64  
65  1 Y 1 A THR 96  ? A THR 65  
66  1 Y 1 A GLU 97  ? A GLU 66  
67  1 Y 1 A GLY 98  ? A GLY 67  
68  1 Y 1 A PRO 99  ? A PRO 68  
69  1 Y 1 A SER 100 ? A SER 69  
70  1 Y 1 A SER 101 ? A SER 70  
71  1 Y 1 A GLY 102 ? A GLY 71  
72  1 Y 1 A THR 103 ? A THR 72  
73  1 Y 1 A THR 104 ? A THR 73  
74  1 Y 1 A ALA 105 ? A ALA 74  
75  1 Y 1 A SER 106 ? A SER 75  
76  1 Y 1 A LEU 107 ? A LEU 76  
77  1 Y 1 A ASN 121 ? A ASN 90  
78  1 Y 1 A SER 122 ? A SER 91  
79  1 Y 1 A ALA 123 ? A ALA 92  
80  1 Y 1 A ASP 124 ? A ASP 93  
81  1 Y 1 A GLU 125 ? A GLU 94  
82  1 Y 1 A GLY 126 ? A GLY 95  
83  1 Y 1 A GLY 392 ? A GLY 361 
84  1 Y 1 A GLU 393 ? A GLU 362 
85  1 Y 1 A GLU 394 ? A GLU 363 
86  1 Y 1 A HIS 395 ? A HIS 364 
87  1 Y 1 A THR 451 ? A THR 420 
88  1 Y 1 A LEU 452 ? A LEU 421 
89  1 Y 1 A ASP 453 ? A ASP 422 
90  1 Y 1 A LYS 454 ? A LYS 423 
91  1 Y 1 A ILE 455 ? A ILE 424 
92  1 Y 1 A THR 456 ? A THR 425 
93  1 Y 1 A GLY 457 ? A GLY 426 
94  1 Y 1 A GLU 458 ? A GLU 427 
95  1 Y 1 A SER 459 ? A SER 428 
96  1 Y 1 A ARG 460 ? A ARG 429 
97  1 Y 1 A GLN 502 ? A GLN 471 
98  1 Y 1 A TYR 503 ? A TYR 472 
99  1 Y 1 A SER 504 ? A SER 473 
100 1 Y 1 A ALA 505 ? A ALA 474 
101 1 Y 1 A GLY 506 ? A GLY 475 
102 1 Y 1 A ASP 507 ? A ASP 476 
103 1 Y 1 A ASN 508 ? A ASN 477 
104 1 Y 1 A ARG 509 ? A ARG 478 
105 1 Y 1 A ARG 510 ? A ARG 479 
106 1 Y 1 A TYR 511 ? A TYR 480 
107 1 Y 1 A PRO 512 ? A PRO 481 
108 1 Y 1 A PHE 513 ? A PHE 482 
109 1 Y 1 A LEU 514 ? A LEU 483 
110 1 Y 1 A PHE 515 ? A PHE 484 
111 1 Y 1 A ASP 516 ? A ASP 485 
112 1 Y 1 A GLY 517 ? A GLY 486 
113 1 Y 1 A GLU 518 ? A GLU 487 
114 1 Y 1 A SER 519 ? A SER 488 
115 1 Y 1 A VAL 520 ? A VAL 489 
116 1 Y 1 A TRP 530 ? A TRP 499 
117 1 Y 1 A HIS 531 ? A HIS 500 
118 1 Y 1 A HIS 532 ? A HIS 501 
119 1 Y 1 A HIS 533 ? A HIS 502 
120 1 Y 1 A HIS 534 ? A HIS 503 
121 1 Y 1 A HIS 535 ? A HIS 504 
122 1 Y 1 A HIS 536 ? A HIS 505 
123 1 Y 1 B CYS 32  ? B CYS 1   
124 1 Y 1 B HIS 33  ? B HIS 2   
125 1 Y 1 B GLY 34  ? B GLY 3   
126 1 Y 1 B ALA 35  ? B ALA 4   
127 1 Y 1 B ASP 36  ? B ASP 5   
128 1 Y 1 B LEU 37  ? B LEU 6   
129 1 Y 1 B THR 38  ? B THR 7   
130 1 Y 1 B SER 39  ? B SER 8   
131 1 Y 1 B PRO 40  ? B PRO 9   
132 1 Y 1 B THR 41  ? B THR 10  
133 1 Y 1 B LYS 42  ? B LYS 11  
134 1 Y 1 B LYS 43  ? B LYS 12  
135 1 Y 1 B SER 44  ? B SER 13  
136 1 Y 1 B ALA 45  ? B ALA 14  
137 1 Y 1 B PRO 46  ? B PRO 15  
138 1 Y 1 B LEU 47  ? B LEU 16  
139 1 Y 1 B ARG 48  ? B ARG 17  
140 1 Y 1 B ILE 49  ? B ILE 18  
141 1 Y 1 B THR 50  ? B THR 19  
142 1 Y 1 B LYS 51  ? B LYS 20  
143 1 Y 1 B PRO 52  ? B PRO 21  
144 1 Y 1 B GLN 53  ? B GLN 22  
145 1 Y 1 B PRO 54  ? B PRO 23  
146 1 Y 1 B THR 55  ? B THR 24  
147 1 Y 1 B SER 56  ? B SER 25  
148 1 Y 1 B GLN 57  ? B GLN 26  
149 1 Y 1 B GLN 58  ? B GLN 27  
150 1 Y 1 B ALA 59  ? B ALA 28  
151 1 Y 1 B LYS 60  ? B LYS 29  
152 1 Y 1 B PRO 61  ? B PRO 30  
153 1 Y 1 B ILE 62  ? B ILE 31  
154 1 Y 1 B SER 63  ? B SER 32  
155 1 Y 1 B ILE 64  ? B ILE 33  
156 1 Y 1 B THR 65  ? B THR 34  
157 1 Y 1 B THR 66  ? B THR 35  
158 1 Y 1 B ARG 67  ? B ARG 36  
159 1 Y 1 B ALA 68  ? B ALA 37  
160 1 Y 1 B PRO 69  ? B PRO 38  
161 1 Y 1 B THR 70  ? B THR 39  
162 1 Y 1 B THR 71  ? B THR 40  
163 1 Y 1 B VAL 72  ? B VAL 41  
164 1 Y 1 B ALA 73  ? B ALA 42  
165 1 Y 1 B SER 74  ? B SER 43  
166 1 Y 1 B THR 75  ? B THR 44  
167 1 Y 1 B THR 76  ? B THR 45  
168 1 Y 1 B ASP 77  ? B ASP 46  
169 1 Y 1 B ASP 78  ? B ASP 47  
170 1 Y 1 B GLU 79  ? B GLU 48  
171 1 Y 1 B VAL 80  ? B VAL 49  
172 1 Y 1 B SER 81  ? B SER 50  
173 1 Y 1 B SER 82  ? B SER 51  
174 1 Y 1 B SER 83  ? B SER 52  
175 1 Y 1 B VAL 84  ? B VAL 53  
176 1 Y 1 B ASP 85  ? B ASP 54  
177 1 Y 1 B GLY 86  ? B GLY 55  
178 1 Y 1 B GLN 87  ? B GLN 56  
179 1 Y 1 B LEU 88  ? B LEU 57  
180 1 Y 1 B ALA 89  ? B ALA 58  
181 1 Y 1 B PRO 90  ? B PRO 59  
182 1 Y 1 B LEU 91  ? B LEU 60  
183 1 Y 1 B ILE 92  ? B ILE 61  
184 1 Y 1 B SER 93  ? B SER 62  
185 1 Y 1 B SER 94  ? B SER 63  
186 1 Y 1 B THR 95  ? B THR 64  
187 1 Y 1 B THR 96  ? B THR 65  
188 1 Y 1 B GLU 97  ? B GLU 66  
189 1 Y 1 B GLY 98  ? B GLY 67  
190 1 Y 1 B PRO 99  ? B PRO 68  
191 1 Y 1 B SER 100 ? B SER 69  
192 1 Y 1 B SER 101 ? B SER 70  
193 1 Y 1 B GLY 102 ? B GLY 71  
194 1 Y 1 B THR 103 ? B THR 72  
195 1 Y 1 B THR 104 ? B THR 73  
196 1 Y 1 B ALA 105 ? B ALA 74  
197 1 Y 1 B SER 106 ? B SER 75  
198 1 Y 1 B LEU 107 ? B LEU 76  
199 1 Y 1 B ASN 121 ? B ASN 90  
200 1 Y 1 B SER 122 ? B SER 91  
201 1 Y 1 B ALA 123 ? B ALA 92  
202 1 Y 1 B ASP 124 ? B ASP 93  
203 1 Y 1 B GLU 125 ? B GLU 94  
204 1 Y 1 B GLY 126 ? B GLY 95  
205 1 Y 1 B GLY 392 ? B GLY 361 
206 1 Y 1 B GLU 393 ? B GLU 362 
207 1 Y 1 B GLU 394 ? B GLU 363 
208 1 Y 1 B HIS 395 ? B HIS 364 
209 1 Y 1 B THR 451 ? B THR 420 
210 1 Y 1 B LEU 452 ? B LEU 421 
211 1 Y 1 B ASP 453 ? B ASP 422 
212 1 Y 1 B LYS 454 ? B LYS 423 
213 1 Y 1 B ILE 455 ? B ILE 424 
214 1 Y 1 B THR 456 ? B THR 425 
215 1 Y 1 B GLY 457 ? B GLY 426 
216 1 Y 1 B GLU 458 ? B GLU 427 
217 1 Y 1 B SER 459 ? B SER 428 
218 1 Y 1 B ARG 460 ? B ARG 429 
219 1 Y 1 B GLN 502 ? B GLN 471 
220 1 Y 1 B TYR 503 ? B TYR 472 
221 1 Y 1 B SER 504 ? B SER 473 
222 1 Y 1 B ALA 505 ? B ALA 474 
223 1 Y 1 B GLY 506 ? B GLY 475 
224 1 Y 1 B ASP 507 ? B ASP 476 
225 1 Y 1 B ASN 508 ? B ASN 477 
226 1 Y 1 B ARG 509 ? B ARG 478 
227 1 Y 1 B ARG 510 ? B ARG 479 
228 1 Y 1 B TYR 511 ? B TYR 480 
229 1 Y 1 B PRO 512 ? B PRO 481 
230 1 Y 1 B PHE 513 ? B PHE 482 
231 1 Y 1 B LEU 514 ? B LEU 483 
232 1 Y 1 B PHE 515 ? B PHE 484 
233 1 Y 1 B ASP 516 ? B ASP 485 
234 1 Y 1 B GLY 517 ? B GLY 486 
235 1 Y 1 B GLU 518 ? B GLU 487 
236 1 Y 1 B SER 519 ? B SER 488 
237 1 Y 1 B VAL 520 ? B VAL 489 
238 1 Y 1 B TRP 530 ? B TRP 499 
239 1 Y 1 B HIS 531 ? B HIS 500 
240 1 Y 1 B HIS 532 ? B HIS 501 
241 1 Y 1 B HIS 533 ? B HIS 502 
242 1 Y 1 B HIS 534 ? B HIS 503 
243 1 Y 1 B HIS 535 ? B HIS 504 
244 1 Y 1 B HIS 536 ? B HIS 505 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
NAG C1   C N R 247 
NAG C2   C N R 248 
NAG C3   C N R 249 
NAG C4   C N S 250 
NAG C5   C N R 251 
NAG C6   C N N 252 
NAG C7   C N N 253 
NAG C8   C N N 254 
NAG N2   N N N 255 
NAG O1   O N N 256 
NAG O3   O N N 257 
NAG O4   O N N 258 
NAG O5   O N N 259 
NAG O6   O N N 260 
NAG O7   O N N 261 
NAG H1   H N N 262 
NAG H2   H N N 263 
NAG H3   H N N 264 
NAG H4   H N N 265 
NAG H5   H N N 266 
NAG H61  H N N 267 
NAG H62  H N N 268 
NAG H81  H N N 269 
NAG H82  H N N 270 
NAG H83  H N N 271 
NAG HN2  H N N 272 
NAG HO1  H N N 273 
NAG HO3  H N N 274 
NAG HO4  H N N 275 
NAG HO6  H N N 276 
PHE N    N N N 277 
PHE CA   C N S 278 
PHE C    C N N 279 
PHE O    O N N 280 
PHE CB   C N N 281 
PHE CG   C Y N 282 
PHE CD1  C Y N 283 
PHE CD2  C Y N 284 
PHE CE1  C Y N 285 
PHE CE2  C Y N 286 
PHE CZ   C Y N 287 
PHE OXT  O N N 288 
PHE H    H N N 289 
PHE H2   H N N 290 
PHE HA   H N N 291 
PHE HB2  H N N 292 
PHE HB3  H N N 293 
PHE HD1  H N N 294 
PHE HD2  H N N 295 
PHE HE1  H N N 296 
PHE HE2  H N N 297 
PHE HZ   H N N 298 
PHE HXT  H N N 299 
PRO N    N N N 300 
PRO CA   C N S 301 
PRO C    C N N 302 
PRO O    O N N 303 
PRO CB   C N N 304 
PRO CG   C N N 305 
PRO CD   C N N 306 
PRO OXT  O N N 307 
PRO H    H N N 308 
PRO HA   H N N 309 
PRO HB2  H N N 310 
PRO HB3  H N N 311 
PRO HG2  H N N 312 
PRO HG3  H N N 313 
PRO HD2  H N N 314 
PRO HD3  H N N 315 
PRO HXT  H N N 316 
SER N    N N N 317 
SER CA   C N S 318 
SER C    C N N 319 
SER O    O N N 320 
SER CB   C N N 321 
SER OG   O N N 322 
SER OXT  O N N 323 
SER H    H N N 324 
SER H2   H N N 325 
SER HA   H N N 326 
SER HB2  H N N 327 
SER HB3  H N N 328 
SER HG   H N N 329 
SER HXT  H N N 330 
THR N    N N N 331 
THR CA   C N S 332 
THR C    C N N 333 
THR O    O N N 334 
THR CB   C N R 335 
THR OG1  O N N 336 
THR CG2  C N N 337 
THR OXT  O N N 338 
THR H    H N N 339 
THR H2   H N N 340 
THR HA   H N N 341 
THR HB   H N N 342 
THR HG1  H N N 343 
THR HG21 H N N 344 
THR HG22 H N N 345 
THR HG23 H N N 346 
THR HXT  H N N 347 
TRP N    N N N 348 
TRP CA   C N S 349 
TRP C    C N N 350 
TRP O    O N N 351 
TRP CB   C N N 352 
TRP CG   C Y N 353 
TRP CD1  C Y N 354 
TRP CD2  C Y N 355 
TRP NE1  N Y N 356 
TRP CE2  C Y N 357 
TRP CE3  C Y N 358 
TRP CZ2  C Y N 359 
TRP CZ3  C Y N 360 
TRP CH2  C Y N 361 
TRP OXT  O N N 362 
TRP H    H N N 363 
TRP H2   H N N 364 
TRP HA   H N N 365 
TRP HB2  H N N 366 
TRP HB3  H N N 367 
TRP HD1  H N N 368 
TRP HE1  H N N 369 
TRP HE3  H N N 370 
TRP HZ2  H N N 371 
TRP HZ3  H N N 372 
TRP HH2  H N N 373 
TRP HXT  H N N 374 
TYR N    N N N 375 
TYR CA   C N S 376 
TYR C    C N N 377 
TYR O    O N N 378 
TYR CB   C N N 379 
TYR CG   C Y N 380 
TYR CD1  C Y N 381 
TYR CD2  C Y N 382 
TYR CE1  C Y N 383 
TYR CE2  C Y N 384 
TYR CZ   C Y N 385 
TYR OH   O N N 386 
TYR OXT  O N N 387 
TYR H    H N N 388 
TYR H2   H N N 389 
TYR HA   H N N 390 
TYR HB2  H N N 391 
TYR HB3  H N N 392 
TYR HD1  H N N 393 
TYR HD2  H N N 394 
TYR HE1  H N N 395 
TYR HE2  H N N 396 
TYR HH   H N N 397 
TYR HXT  H N N 398 
VAL N    N N N 399 
VAL CA   C N S 400 
VAL C    C N N 401 
VAL O    O N N 402 
VAL CB   C N N 403 
VAL CG1  C N N 404 
VAL CG2  C N N 405 
VAL OXT  O N N 406 
VAL H    H N N 407 
VAL H2   H N N 408 
VAL HA   H N N 409 
VAL HB   H N N 410 
VAL HG11 H N N 411 
VAL HG12 H N N 412 
VAL HG13 H N N 413 
VAL HG21 H N N 414 
VAL HG22 H N N 415 
VAL HG23 H N N 416 
VAL HXT  H N N 417 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
NAG C1  C2   sing N N 235 
NAG C1  O1   sing N N 236 
NAG C1  O5   sing N N 237 
NAG C1  H1   sing N N 238 
NAG C2  C3   sing N N 239 
NAG C2  N2   sing N N 240 
NAG C2  H2   sing N N 241 
NAG C3  C4   sing N N 242 
NAG C3  O3   sing N N 243 
NAG C3  H3   sing N N 244 
NAG C4  C5   sing N N 245 
NAG C4  O4   sing N N 246 
NAG C4  H4   sing N N 247 
NAG C5  C6   sing N N 248 
NAG C5  O5   sing N N 249 
NAG C5  H5   sing N N 250 
NAG C6  O6   sing N N 251 
NAG C6  H61  sing N N 252 
NAG C6  H62  sing N N 253 
NAG C7  C8   sing N N 254 
NAG C7  N2   sing N N 255 
NAG C7  O7   doub N N 256 
NAG C8  H81  sing N N 257 
NAG C8  H82  sing N N 258 
NAG C8  H83  sing N N 259 
NAG N2  HN2  sing N N 260 
NAG O1  HO1  sing N N 261 
NAG O3  HO3  sing N N 262 
NAG O4  HO4  sing N N 263 
NAG O6  HO6  sing N N 264 
PHE N   CA   sing N N 265 
PHE N   H    sing N N 266 
PHE N   H2   sing N N 267 
PHE CA  C    sing N N 268 
PHE CA  CB   sing N N 269 
PHE CA  HA   sing N N 270 
PHE C   O    doub N N 271 
PHE C   OXT  sing N N 272 
PHE CB  CG   sing N N 273 
PHE CB  HB2  sing N N 274 
PHE CB  HB3  sing N N 275 
PHE CG  CD1  doub Y N 276 
PHE CG  CD2  sing Y N 277 
PHE CD1 CE1  sing Y N 278 
PHE CD1 HD1  sing N N 279 
PHE CD2 CE2  doub Y N 280 
PHE CD2 HD2  sing N N 281 
PHE CE1 CZ   doub Y N 282 
PHE CE1 HE1  sing N N 283 
PHE CE2 CZ   sing Y N 284 
PHE CE2 HE2  sing N N 285 
PHE CZ  HZ   sing N N 286 
PHE OXT HXT  sing N N 287 
PRO N   CA   sing N N 288 
PRO N   CD   sing N N 289 
PRO N   H    sing N N 290 
PRO CA  C    sing N N 291 
PRO CA  CB   sing N N 292 
PRO CA  HA   sing N N 293 
PRO C   O    doub N N 294 
PRO C   OXT  sing N N 295 
PRO CB  CG   sing N N 296 
PRO CB  HB2  sing N N 297 
PRO CB  HB3  sing N N 298 
PRO CG  CD   sing N N 299 
PRO CG  HG2  sing N N 300 
PRO CG  HG3  sing N N 301 
PRO CD  HD2  sing N N 302 
PRO CD  HD3  sing N N 303 
PRO OXT HXT  sing N N 304 
SER N   CA   sing N N 305 
SER N   H    sing N N 306 
SER N   H2   sing N N 307 
SER CA  C    sing N N 308 
SER CA  CB   sing N N 309 
SER CA  HA   sing N N 310 
SER C   O    doub N N 311 
SER C   OXT  sing N N 312 
SER CB  OG   sing N N 313 
SER CB  HB2  sing N N 314 
SER CB  HB3  sing N N 315 
SER OG  HG   sing N N 316 
SER OXT HXT  sing N N 317 
THR N   CA   sing N N 318 
THR N   H    sing N N 319 
THR N   H2   sing N N 320 
THR CA  C    sing N N 321 
THR CA  CB   sing N N 322 
THR CA  HA   sing N N 323 
THR C   O    doub N N 324 
THR C   OXT  sing N N 325 
THR CB  OG1  sing N N 326 
THR CB  CG2  sing N N 327 
THR CB  HB   sing N N 328 
THR OG1 HG1  sing N N 329 
THR CG2 HG21 sing N N 330 
THR CG2 HG22 sing N N 331 
THR CG2 HG23 sing N N 332 
THR OXT HXT  sing N N 333 
TRP N   CA   sing N N 334 
TRP N   H    sing N N 335 
TRP N   H2   sing N N 336 
TRP CA  C    sing N N 337 
TRP CA  CB   sing N N 338 
TRP CA  HA   sing N N 339 
TRP C   O    doub N N 340 
TRP C   OXT  sing N N 341 
TRP CB  CG   sing N N 342 
TRP CB  HB2  sing N N 343 
TRP CB  HB3  sing N N 344 
TRP CG  CD1  doub Y N 345 
TRP CG  CD2  sing Y N 346 
TRP CD1 NE1  sing Y N 347 
TRP CD1 HD1  sing N N 348 
TRP CD2 CE2  doub Y N 349 
TRP CD2 CE3  sing Y N 350 
TRP NE1 CE2  sing Y N 351 
TRP NE1 HE1  sing N N 352 
TRP CE2 CZ2  sing Y N 353 
TRP CE3 CZ3  doub Y N 354 
TRP CE3 HE3  sing N N 355 
TRP CZ2 CH2  doub Y N 356 
TRP CZ2 HZ2  sing N N 357 
TRP CZ3 CH2  sing Y N 358 
TRP CZ3 HZ3  sing N N 359 
TRP CH2 HH2  sing N N 360 
TRP OXT HXT  sing N N 361 
TYR N   CA   sing N N 362 
TYR N   H    sing N N 363 
TYR N   H2   sing N N 364 
TYR CA  C    sing N N 365 
TYR CA  CB   sing N N 366 
TYR CA  HA   sing N N 367 
TYR C   O    doub N N 368 
TYR C   OXT  sing N N 369 
TYR CB  CG   sing N N 370 
TYR CB  HB2  sing N N 371 
TYR CB  HB3  sing N N 372 
TYR CG  CD1  doub Y N 373 
TYR CG  CD2  sing Y N 374 
TYR CD1 CE1  sing Y N 375 
TYR CD1 HD1  sing N N 376 
TYR CD2 CE2  doub Y N 377 
TYR CD2 HD2  sing N N 378 
TYR CE1 CZ   doub Y N 379 
TYR CE1 HE1  sing N N 380 
TYR CE2 CZ   sing Y N 381 
TYR CE2 HE2  sing N N 382 
TYR CZ  OH   sing N N 383 
TYR OH  HH   sing N N 384 
TYR OXT HXT  sing N N 385 
VAL N   CA   sing N N 386 
VAL N   H    sing N N 387 
VAL N   H2   sing N N 388 
VAL CA  C    sing N N 389 
VAL CA  CB   sing N N 390 
VAL CA  HA   sing N N 391 
VAL C   O    doub N N 392 
VAL C   OXT  sing N N 393 
VAL CB  CG1  sing N N 394 
VAL CB  CG2  sing N N 395 
VAL CB  HB   sing N N 396 
VAL CG1 HG11 sing N N 397 
VAL CG1 HG12 sing N N 398 
VAL CG1 HG13 sing N N 399 
VAL CG2 HG21 sing N N 400 
VAL CG2 HG22 sing N N 401 
VAL CG2 HG23 sing N N 402 
VAL OXT HXT  sing N N 403 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-04-18 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           9BFR 
_em_admin.last_update        2025-05-14 
_em_admin.map_release_date   2025-01-29 
_em_admin.title              'Cryo-EM structure of Bride of Sevenless extracellular domain (dimer, Sevenless-bound form)' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                ? 
_em_entity_assembly_molwt.value                ? 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          7227 
_em_entity_assembly_naturalsource.organism             'Drosophila melanogaster' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          7227 
_em_entity_assembly_recombinant.organism             'Drosophila melanogaster' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         51.8 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ?      ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 ?      ? 
MASKING                    ? 3  ? ? ? ?      ? 
'CTF CORRECTION'           ? 4  1 ? ? ?      ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ?      ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ?      ? 
'MODEL FITTING'            ? 7  ? ? ? ?      ? 
'MODEL REFINEMENT'         ? 8  ? ? ? PHENIX ? 
OTHER                      ? 9  ? ? ? ?      ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? ?      ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ?      ? 
CLASSIFICATION             ? 12 1 ? ? ?      ? 
RECONSTRUCTION             ? 13 1 ? ? ?      ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'Other private' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    9BFR 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . VAL A 1 77  ? 85.481  124.225 103.312 1.00 41.20  ? 108 VAL A N   1 
ATOM   2    C CA  . VAL A 1 77  ? 86.186  124.796 104.448 1.00 40.66  ? 108 VAL A CA  1 
ATOM   3    C C   . VAL A 1 77  ? 86.117  123.792 105.613 1.00 51.71  ? 108 VAL A C   1 
ATOM   4    O O   . VAL A 1 77  ? 85.024  123.353 105.969 1.00 60.01  ? 108 VAL A O   1 
ATOM   5    C CB  . VAL A 1 77  ? 85.592  126.157 104.824 1.00 44.32  ? 108 VAL A CB  1 
ATOM   6    C CG1 . VAL A 1 77  ? 86.274  126.725 106.051 1.00 55.21  ? 108 VAL A CG1 1 
ATOM   7    C CG2 . VAL A 1 77  ? 85.686  127.115 103.655 1.00 44.15  ? 108 VAL A CG2 1 
ATOM   8    N N   . PRO A 1 78  ? 87.264  123.418 106.195 1.00 56.13  ? 109 PRO A N   1 
ATOM   9    C CA  . PRO A 1 78  ? 87.267  122.335 107.192 1.00 56.69  ? 109 PRO A CA  1 
ATOM   10   C C   . PRO A 1 78  ? 86.773  122.769 108.568 1.00 51.16  ? 109 PRO A C   1 
ATOM   11   O O   . PRO A 1 78  ? 86.332  123.899 108.783 1.00 49.50  ? 109 PRO A O   1 
ATOM   12   C CB  . PRO A 1 78  ? 88.742  121.916 107.256 1.00 55.27  ? 109 PRO A CB  1 
ATOM   13   C CG  . PRO A 1 78  ? 89.353  122.447 105.990 1.00 57.75  ? 109 PRO A CG  1 
ATOM   14   C CD  . PRO A 1 78  ? 88.637  123.741 105.767 1.00 51.95  ? 109 PRO A CD  1 
ATOM   15   N N   . GLU A 1 79  ? 86.870  121.826 109.512 1.00 47.30  ? 110 GLU A N   1 
ATOM   16   C CA  . GLU A 1 79  ? 86.292  122.002 110.845 1.00 45.53  ? 110 GLU A CA  1 
ATOM   17   C C   . GLU A 1 79  ? 87.139  122.931 111.712 1.00 41.90  ? 110 GLU A C   1 
ATOM   18   O O   . GLU A 1 79  ? 86.609  123.648 112.576 1.00 40.82  ? 110 GLU A O   1 
ATOM   19   C CB  . GLU A 1 79  ? 86.144  120.633 111.511 1.00 45.51  ? 110 GLU A CB  1 
ATOM   20   C CG  . GLU A 1 79  ? 85.263  120.589 112.745 1.00 46.79  ? 110 GLU A CG  1 
ATOM   21   C CD  . GLU A 1 79  ? 85.414  119.292 113.518 1.00 52.30  ? 110 GLU A CD  1 
ATOM   22   O OE1 . GLU A 1 79  ? 86.175  118.412 113.063 1.00 54.64  ? 110 GLU A OE1 1 
ATOM   23   O OE2 . GLU A 1 79  ? 84.781  119.158 114.587 1.00 47.29  ? 110 GLU A OE2 1 
ATOM   24   N N   . ILE A 1 80  ? 88.454  122.954 111.469 1.00 41.11  ? 111 ILE A N   1 
ATOM   25   C CA  . ILE A 1 80  ? 89.386  123.688 112.325 1.00 38.35  ? 111 ILE A CA  1 
ATOM   26   C C   . ILE A 1 80  ? 89.307  125.193 112.031 1.00 39.77  ? 111 ILE A C   1 
ATOM   27   O O   . ILE A 1 80  ? 89.552  126.031 112.908 1.00 42.15  ? 111 ILE A O   1 
ATOM   28   C CB  . ILE A 1 80  ? 90.806  123.085 112.154 1.00 37.81  ? 111 ILE A CB  1 
ATOM   29   C CG1 . ILE A 1 80  ? 91.870  123.701 113.077 1.00 37.17  ? 111 ILE A CG1 1 
ATOM   30   C CG2 . ILE A 1 80  ? 91.264  123.110 110.700 1.00 43.16  ? 111 ILE A CG2 1 
ATOM   31   C CD1 . ILE A 1 80  ? 93.116  122.877 113.204 1.00 38.10  ? 111 ILE A CD1 1 
ATOM   32   N N   . CYS A 1 81  ? 88.846  125.558 110.832 1.00 37.18  ? 112 CYS A N   1 
ATOM   33   C CA  . CYS A 1 81  ? 88.636  126.968 110.522 1.00 37.91  ? 112 CYS A CA  1 
ATOM   34   C C   . CYS A 1 81  ? 87.348  127.495 111.147 1.00 38.77  ? 112 CYS A C   1 
ATOM   35   O O   . CYS A 1 81  ? 87.279  128.664 111.543 1.00 36.59  ? 112 CYS A O   1 
ATOM   36   C CB  . CYS A 1 81  ? 88.623  127.172 109.010 1.00 39.77  ? 112 CYS A CB  1 
ATOM   37   S SG  . CYS A 1 81  ? 89.951  126.318 108.147 1.00 36.83  ? 112 CYS A SG  1 
ATOM   38   N N   . LEU A 1 82  ? 86.311  126.653 111.232 1.00 40.36  ? 113 LEU A N   1 
ATOM   39   C CA  . LEU A 1 82  ? 85.060  127.084 111.855 1.00 40.70  ? 113 LEU A CA  1 
ATOM   40   C C   . LEU A 1 82  ? 85.166  127.138 113.374 1.00 42.60  ? 113 LEU A C   1 
ATOM   41   O O   . LEU A 1 82  ? 84.658  128.077 113.998 1.00 50.39  ? 113 LEU A O   1 
ATOM   42   C CB  . LEU A 1 82  ? 83.896  126.176 111.447 1.00 42.13  ? 113 LEU A CB  1 
ATOM   43   C CG  . LEU A 1 82  ? 83.072  126.440 110.178 1.00 45.97  ? 113 LEU A CG  1 
ATOM   44   C CD1 . LEU A 1 82  ? 83.807  126.131 108.891 1.00 38.43  ? 113 LEU A CD1 1 
ATOM   45   C CD2 . LEU A 1 82  ? 81.756  125.672 110.235 1.00 46.23  ? 113 LEU A CD2 1 
ATOM   46   N N   . ASN A 1 83  ? 85.806  126.148 113.995 1.00 37.95  ? 114 ASN A N   1 
ATOM   47   C CA  . ASN A 1 83  ? 85.824  126.074 115.451 1.00 32.71  ? 114 ASN A CA  1 
ATOM   48   C C   . ASN A 1 83  ? 87.043  126.735 116.081 1.00 30.06  ? 114 ASN A C   1 
ATOM   49   O O   . ASN A 1 83  ? 86.975  127.150 117.241 1.00 26.86  ? 114 ASN A O   1 
ATOM   50   C CB  . ASN A 1 83  ? 85.725  124.621 115.908 1.00 36.73  ? 114 ASN A CB  1 
ATOM   51   C CG  . ASN A 1 83  ? 84.350  124.038 115.677 1.00 42.83  ? 114 ASN A CG  1 
ATOM   52   O OD1 . ASN A 1 83  ? 83.338  124.698 115.911 1.00 40.76  ? 114 ASN A OD1 1 
ATOM   53   N ND2 . ASN A 1 83  ? 84.305  122.792 115.228 1.00 48.42  ? 114 ASN A ND2 1 
ATOM   54   N N   . GLY A 1 84  ? 88.142  126.862 115.350 1.00 33.25  ? 115 GLY A N   1 
ATOM   55   C CA  . GLY A 1 84  ? 89.334  127.447 115.939 1.00 33.30  ? 115 GLY A CA  1 
ATOM   56   C C   . GLY A 1 84  ? 90.189  126.399 116.611 1.00 35.69  ? 115 GLY A C   1 
ATOM   57   O O   . GLY A 1 84  ? 90.187  125.224 116.228 1.00 38.12  ? 115 GLY A O   1 
ATOM   58   N N   . LEU A 1 85  ? 90.936  126.819 117.625 1.00 37.14  ? 116 LEU A N   1 
ATOM   59   C CA  . LEU A 1 85  ? 91.810  125.940 118.388 1.00 45.51  ? 116 LEU A CA  1 
ATOM   60   C C   . LEU A 1 85  ? 91.146  125.595 119.716 1.00 49.35  ? 116 LEU A C   1 
ATOM   61   O O   . LEU A 1 85  ? 90.477  126.437 120.322 1.00 60.69  ? 116 LEU A O   1 
ATOM   62   C CB  . LEU A 1 85  ? 93.172  126.592 118.642 1.00 43.05  ? 116 LEU A CB  1 
ATOM   63   C CG  . LEU A 1 85  ? 94.006  127.161 117.493 1.00 39.74  ? 116 LEU A CG  1 
ATOM   64   C CD1 . LEU A 1 85  ? 95.414  127.444 117.982 1.00 38.48  ? 116 LEU A CD1 1 
ATOM   65   C CD2 . LEU A 1 85  ? 94.056  126.212 116.312 1.00 38.86  ? 116 LEU A CD2 1 
ATOM   66   N N   . GLN A 1 86  ? 91.323  124.355 120.162 1.00 38.08  ? 117 GLN A N   1 
ATOM   67   C CA  . GLN A 1 86  ? 90.657  123.849 121.354 1.00 41.03  ? 117 GLN A CA  1 
ATOM   68   C C   . GLN A 1 86  ? 91.673  123.189 122.274 1.00 51.08  ? 117 GLN A C   1 
ATOM   69   O O   . GLN A 1 86  ? 92.681  122.652 121.804 1.00 54.38  ? 117 GLN A O   1 
ATOM   70   C CB  . GLN A 1 86  ? 89.556  122.857 120.981 1.00 37.95  ? 117 GLN A CB  1 
ATOM   71   C CG  . GLN A 1 86  ? 88.308  123.506 120.416 1.00 33.78  ? 117 GLN A CG  1 
ATOM   72   C CD  . GLN A 1 86  ? 87.622  122.649 119.381 1.00 32.67  ? 117 GLN A CD  1 
ATOM   73   O OE1 . GLN A 1 86  ? 88.273  122.002 118.563 1.00 34.55  ? 117 GLN A OE1 1 
ATOM   74   N NE2 . GLN A 1 86  ? 86.296  122.637 119.410 1.00 31.70  ? 117 GLN A NE2 1 
ATOM   75   N N   . LEU A 1 87  ? 91.412  123.244 123.582 1.00 55.30  ? 118 LEU A N   1 
ATOM   76   C CA  . LEU A 1 87  ? 92.245  122.588 124.587 1.00 61.42  ? 118 LEU A CA  1 
ATOM   77   C C   . LEU A 1 87  ? 91.403  121.702 125.489 1.00 67.35  ? 118 LEU A C   1 
ATOM   78   O O   . LEU A 1 87  ? 90.269  122.053 125.831 1.00 66.81  ? 118 LEU A O   1 
ATOM   79   C CB  . LEU A 1 87  ? 93.010  123.595 125.447 1.00 61.12  ? 118 LEU A CB  1 
ATOM   80   C CG  . LEU A 1 87  ? 93.932  124.596 124.777 1.00 56.45  ? 118 LEU A CG  1 
ATOM   81   C CD1 . LEU A 1 87  ? 93.970  125.888 125.550 1.00 55.04  ? 118 LEU A CD1 1 
ATOM   82   C CD2 . LEU A 1 87  ? 95.284  123.948 124.773 1.00 58.34  ? 118 LEU A CD2 1 
ATOM   83   N N   . THR A 1 88  ? 91.971  120.563 125.879 1.00 71.05  ? 119 THR A N   1 
ATOM   84   C CA  . THR A 1 88  ? 91.441  119.738 126.958 1.00 73.75  ? 119 THR A CA  1 
ATOM   85   C C   . THR A 1 88  ? 92.367  119.902 128.157 1.00 73.98  ? 119 THR A C   1 
ATOM   86   O O   . THR A 1 88  ? 93.455  119.319 128.192 1.00 75.61  ? 119 THR A O   1 
ATOM   87   C CB  . THR A 1 88  ? 91.354  118.274 126.532 1.00 73.90  ? 119 THR A CB  1 
ATOM   88   O OG1 . THR A 1 88  ? 92.584  117.883 125.910 1.00 69.90  ? 119 THR A OG1 1 
ATOM   89   C CG2 . THR A 1 88  ? 90.217  118.068 125.549 1.00 68.72  ? 119 THR A CG2 1 
ATOM   90   N N   . VAL A 1 89  ? 91.943  120.693 129.136 1.00 75.19  ? 120 VAL A N   1 
ATOM   91   C CA  . VAL A 1 89  ? 92.795  120.997 130.280 1.00 79.20  ? 120 VAL A CA  1 
ATOM   92   C C   . VAL A 1 89  ? 92.374  120.172 131.490 1.00 72.87  ? 120 VAL A C   1 
ATOM   93   O O   . VAL A 1 89  ? 91.410  120.509 132.176 1.00 71.06  ? 120 VAL A O   1 
ATOM   94   C CB  . VAL A 1 89  ? 92.768  122.501 130.609 1.00 81.10  ? 120 VAL A CB  1 
ATOM   95   C CG1 . VAL A 1 89  ? 93.832  122.841 131.642 1.00 80.07  ? 120 VAL A CG1 1 
ATOM   96   C CG2 . VAL A 1 89  ? 92.962  123.323 129.346 1.00 72.82  ? 120 VAL A CG2 1 
ATOM   97   N N   . THR A 1 96  ? 89.775  118.735 132.990 1.00 141.99 ? 127 THR A N   1 
ATOM   98   C CA  . THR A 1 96  ? 89.021  118.085 131.924 1.00 144.41 ? 127 THR A CA  1 
ATOM   99   C C   . THR A 1 96  ? 87.935  119.018 131.397 1.00 141.94 ? 127 THR A C   1 
ATOM   100  O O   . THR A 1 96  ? 86.784  118.618 131.215 1.00 140.30 ? 127 THR A O   1 
ATOM   101  C CB  . THR A 1 96  ? 88.385  116.770 132.407 1.00 145.08 ? 127 THR A CB  1 
ATOM   102  O OG1 . THR A 1 96  ? 87.611  117.018 133.587 1.00 145.36 ? 127 THR A OG1 1 
ATOM   103  C CG2 . THR A 1 96  ? 89.464  115.748 132.723 1.00 142.61 ? 127 THR A CG2 1 
ATOM   104  N N   . VAL A 1 97  ? 88.320  120.267 131.146 1.00 139.09 ? 128 VAL A N   1 
ATOM   105  C CA  . VAL A 1 97  ? 87.404  121.320 130.723 1.00 134.22 ? 128 VAL A CA  1 
ATOM   106  C C   . VAL A 1 97  ? 87.673  121.610 129.252 1.00 130.28 ? 128 VAL A C   1 
ATOM   107  O O   . VAL A 1 97  ? 88.827  121.819 128.856 1.00 130.51 ? 128 VAL A O   1 
ATOM   108  C CB  . VAL A 1 97  ? 87.573  122.586 131.579 1.00 133.41 ? 128 VAL A CB  1 
ATOM   109  C CG1 . VAL A 1 97  ? 86.507  123.622 131.245 1.00 130.99 ? 128 VAL A CG1 1 
ATOM   110  C CG2 . VAL A 1 97  ? 87.537  122.236 133.060 1.00 132.83 ? 128 VAL A CG2 1 
ATOM   111  N N   . ILE A 1 98  ? 86.614  121.602 128.439 1.00 126.34 ? 129 ILE A N   1 
ATOM   112  C CA  . ILE A 1 98  ? 86.750  122.012 127.048 1.00 123.08 ? 129 ILE A CA  1 
ATOM   113  C C   . ILE A 1 98  ? 86.860  123.527 126.991 1.00 119.92 ? 129 ILE A C   1 
ATOM   114  O O   . ILE A 1 98  ? 85.882  124.249 127.226 1.00 120.69 ? 129 ILE A O   1 
ATOM   115  C CB  . ILE A 1 98  ? 85.561  121.507 126.215 1.00 121.60 ? 129 ILE A CB  1 
ATOM   116  C CG1 . ILE A 1 98  ? 85.424  119.987 126.327 1.00 122.22 ? 129 ILE A CG1 1 
ATOM   117  C CG2 . ILE A 1 98  ? 85.706  121.931 124.755 1.00 116.73 ? 129 ILE A CG2 1 
ATOM   118  C CD1 . ILE A 1 98  ? 86.592  119.213 125.763 1.00 121.36 ? 129 ILE A CD1 1 
ATOM   119  N N   . ARG A 1 99  ? 88.057  124.020 126.689 1.00 114.98 ? 130 ARG A N   1 
ATOM   120  C CA  . ARG A 1 99  ? 88.302  125.451 126.590 1.00 110.39 ? 130 ARG A CA  1 
ATOM   121  C C   . ARG A 1 99  ? 88.118  125.885 125.144 1.00 109.32 ? 130 ARG A C   1 
ATOM   122  O O   . ARG A 1 99  ? 88.756  125.336 124.241 1.00 110.08 ? 130 ARG A O   1 
ATOM   123  C CB  . ARG A 1 99  ? 89.706  125.819 127.082 1.00 106.53 ? 130 ARG A CB  1 
ATOM   124  C CG  . ARG A 1 99  ? 89.977  127.318 127.052 1.00 102.47 ? 130 ARG A CG  1 
ATOM   125  C CD  . ARG A 1 99  ? 91.336  127.687 127.622 1.00 97.23  ? 130 ARG A CD  1 
ATOM   126  N NE  . ARG A 1 99  ? 91.416  127.480 129.062 1.00 94.85  ? 130 ARG A NE  1 
ATOM   127  C CZ  . ARG A 1 99  ? 92.537  127.559 129.766 1.00 93.75  ? 130 ARG A CZ  1 
ATOM   128  N NH1 . ARG A 1 99  ? 93.697  127.823 129.189 1.00 90.89  ? 130 ARG A NH1 1 
ATOM   129  N NH2 . ARG A 1 99  ? 92.493  127.368 131.081 1.00 92.37  ? 130 ARG A NH2 1 
ATOM   130  N N   . LYS A 1 100 ? 87.255  126.876 124.934 1.00 105.67 ? 131 LYS A N   1 
ATOM   131  C CA  . LYS A 1 100 ? 87.002  127.423 123.611 1.00 101.08 ? 131 LYS A CA  1 
ATOM   132  C C   . LYS A 1 100 ? 88.138  128.361 123.203 1.00 97.14  ? 131 LYS A C   1 
ATOM   133  O O   . LYS A 1 100 ? 89.007  128.704 124.010 1.00 94.26  ? 131 LYS A O   1 
ATOM   134  C CB  . LYS A 1 100 ? 85.659  128.161 123.592 1.00 100.49 ? 131 LYS A CB  1 
ATOM   135  C CG  . LYS A 1 100 ? 84.799  127.953 122.340 1.00 100.37 ? 131 LYS A CG  1 
ATOM   136  C CD  . LYS A 1 100 ? 84.637  126.483 121.986 1.00 101.59 ? 131 LYS A CD  1 
ATOM   137  C CE  . LYS A 1 100 ? 83.854  126.315 120.695 1.00 99.31  ? 131 LYS A CE  1 
ATOM   138  N NZ  . LYS A 1 100 ? 83.750  124.888 120.286 1.00 95.77  ? 131 LYS A NZ  1 
ATOM   139  N N   . GLN A 1 101 ? 88.094  128.796 121.934 1.00 96.14  ? 132 GLN A N   1 
ATOM   140  C CA  . GLN A 1 101 ? 89.211  129.505 121.307 1.00 91.35  ? 132 GLN A CA  1 
ATOM   141  C C   . GLN A 1 101 ? 89.371  130.928 121.837 1.00 91.69  ? 132 GLN A C   1 
ATOM   142  O O   . GLN A 1 101 ? 90.497  131.410 121.995 1.00 88.44  ? 132 GLN A O   1 
ATOM   143  C CB  . GLN A 1 101 ? 89.021  129.541 119.791 1.00 87.18  ? 132 GLN A CB  1 
ATOM   144  C CG  . GLN A 1 101 ? 90.278  129.896 119.022 1.00 82.93  ? 132 GLN A CG  1 
ATOM   145  C CD  . GLN A 1 101 ? 89.981  130.530 117.686 1.00 83.65  ? 132 GLN A CD  1 
ATOM   146  O OE1 . GLN A 1 101 ? 88.827  130.805 117.361 1.00 87.55  ? 132 GLN A OE1 1 
ATOM   147  N NE2 . GLN A 1 101 ? 91.023  130.781 116.906 1.00 78.31  ? 132 GLN A NE2 1 
ATOM   148  N N   . GLU A 1 102 ? 88.265  131.579 122.215 1.00 91.53  ? 133 GLU A N   1 
ATOM   149  C CA  . GLU A 1 102 ? 88.301  133.014 122.506 1.00 86.36  ? 133 GLU A CA  1 
ATOM   150  C C   . GLU A 1 102 ? 88.852  133.323 123.898 1.00 84.82  ? 133 GLU A C   1 
ATOM   151  O O   . GLU A 1 102 ? 89.067  134.495 124.228 1.00 82.72  ? 133 GLU A O   1 
ATOM   152  C CB  . GLU A 1 102 ? 86.901  133.618 122.356 1.00 86.58  ? 133 GLU A CB  1 
ATOM   153  C CG  . GLU A 1 102 ? 86.535  134.135 120.956 1.00 88.19  ? 133 GLU A CG  1 
ATOM   154  C CD  . GLU A 1 102 ? 86.598  133.072 119.870 1.00 88.86  ? 133 GLU A CD  1 
ATOM   155  O OE1 . GLU A 1 102 ? 86.090  131.954 120.101 1.00 86.53  ? 133 GLU A OE1 1 
ATOM   156  O OE2 . GLU A 1 102 ? 87.154  133.354 118.788 1.00 88.61  ? 133 GLU A OE2 1 
ATOM   157  N N   . GLU A 1 103 ? 89.080  132.300 124.725 1.00 87.87  ? 134 GLU A N   1 
ATOM   158  C CA  . GLU A 1 103 ? 89.668  132.515 126.040 1.00 88.91  ? 134 GLU A CA  1 
ATOM   159  C C   . GLU A 1 103 ? 91.168  132.782 125.957 1.00 84.11  ? 134 GLU A C   1 
ATOM   160  O O   . GLU A 1 103 ? 91.688  133.622 126.701 1.00 86.21  ? 134 GLU A O   1 
ATOM   161  C CB  . GLU A 1 103 ? 89.392  131.309 126.938 1.00 93.61  ? 134 GLU A CB  1 
ATOM   162  C CG  . GLU A 1 103 ? 87.944  130.844 126.936 1.00 97.47  ? 134 GLU A CG  1 
ATOM   163  C CD  . GLU A 1 103 ? 87.633  129.900 128.083 1.00 101.88 ? 134 GLU A CD  1 
ATOM   164  O OE1 . GLU A 1 103 ? 88.290  130.006 129.140 1.00 101.46 ? 134 GLU A OE1 1 
ATOM   165  O OE2 . GLU A 1 103 ? 86.728  129.055 127.931 1.00 105.03 ? 134 GLU A OE2 1 
ATOM   166  N N   . PHE A 1 104 ? 91.887  132.089 125.069 1.00 79.57  ? 135 PHE A N   1 
ATOM   167  C CA  . PHE A 1 104 ? 93.344  132.132 125.148 1.00 75.95  ? 135 PHE A CA  1 
ATOM   168  C C   . PHE A 1 104 ? 94.013  132.944 124.042 1.00 73.76  ? 135 PHE A C   1 
ATOM   169  O O   . PHE A 1 104 ? 95.018  133.607 124.317 1.00 73.25  ? 135 PHE A O   1 
ATOM   170  C CB  . PHE A 1 104 ? 93.955  130.714 125.193 1.00 74.03  ? 135 PHE A CB  1 
ATOM   171  C CG  . PHE A 1 104 ? 93.543  129.785 124.067 1.00 81.58  ? 135 PHE A CG  1 
ATOM   172  C CD1 . PHE A 1 104 ? 94.320  129.695 122.905 1.00 80.76  ? 135 PHE A CD1 1 
ATOM   173  C CD2 . PHE A 1 104 ? 92.431  128.946 124.198 1.00 86.87  ? 135 PHE A CD2 1 
ATOM   174  C CE1 . PHE A 1 104 ? 93.967  128.832 121.869 1.00 82.28  ? 135 PHE A CE1 1 
ATOM   175  C CE2 . PHE A 1 104 ? 92.074  128.070 123.169 1.00 86.89  ? 135 PHE A CE2 1 
ATOM   176  C CZ  . PHE A 1 104 ? 92.842  128.022 122.007 1.00 87.50  ? 135 PHE A CZ  1 
ATOM   177  N N   . VAL A 1 105 ? 93.512  132.928 122.808 1.00 70.52  ? 136 VAL A N   1 
ATOM   178  C CA  . VAL A 1 105 ? 94.164  133.645 121.717 1.00 61.86  ? 136 VAL A CA  1 
ATOM   179  C C   . VAL A 1 105 ? 93.522  135.029 121.643 1.00 62.35  ? 136 VAL A C   1 
ATOM   180  O O   . VAL A 1 105 ? 92.337  135.198 121.960 1.00 66.24  ? 136 VAL A O   1 
ATOM   181  C CB  . VAL A 1 105 ? 94.096  132.861 120.383 1.00 61.31  ? 136 VAL A CB  1 
ATOM   182  C CG1 . VAL A 1 105 ? 92.697  132.685 119.823 1.00 66.08  ? 136 VAL A CG1 1 
ATOM   183  C CG2 . VAL A 1 105 ? 95.043  133.406 119.313 1.00 58.70  ? 136 VAL A CG2 1 
ATOM   184  N N   . LYS A 1 106 ? 94.334  136.047 121.366 1.00 59.78  ? 137 LYS A N   1 
ATOM   185  C CA  . LYS A 1 106 ? 93.842  137.402 121.149 1.00 55.98  ? 137 LYS A CA  1 
ATOM   186  C C   . LYS A 1 106 ? 94.031  137.741 119.675 1.00 52.81  ? 137 LYS A C   1 
ATOM   187  O O   . LYS A 1 106 ? 95.129  138.102 119.244 1.00 47.40  ? 137 LYS A O   1 
ATOM   188  C CB  . LYS A 1 106 ? 94.564  138.389 122.061 1.00 52.20  ? 137 LYS A CB  1 
ATOM   189  C CG  . LYS A 1 106 ? 94.898  137.829 123.433 1.00 51.67  ? 137 LYS A CG  1 
ATOM   190  C CD  . LYS A 1 106 ? 95.325  138.916 124.399 1.00 55.38  ? 137 LYS A CD  1 
ATOM   191  C CE  . LYS A 1 106 ? 94.971  138.534 125.826 1.00 60.79  ? 137 LYS A CE  1 
ATOM   192  N NZ  . LYS A 1 106 ? 95.522  139.490 126.822 1.00 52.26  ? 137 LYS A NZ  1 
ATOM   193  N N   . ILE A 1 107 ? 92.959  137.620 118.905 1.00 53.16  ? 138 ILE A N   1 
ATOM   194  C CA  . ILE A 1 107 ? 93.003  137.746 117.457 1.00 47.98  ? 138 ILE A CA  1 
ATOM   195  C C   . ILE A 1 107 ? 92.899  139.214 117.095 1.00 51.13  ? 138 ILE A C   1 
ATOM   196  O O   . ILE A 1 107 ? 91.881  139.859 117.373 1.00 55.16  ? 138 ILE A O   1 
ATOM   197  C CB  . ILE A 1 107 ? 91.868  136.945 116.801 1.00 53.00  ? 138 ILE A CB  1 
ATOM   198  C CG1 . ILE A 1 107 ? 91.981  135.463 117.170 1.00 58.97  ? 138 ILE A CG1 1 
ATOM   199  C CG2 . ILE A 1 107 ? 91.875  137.157 115.293 1.00 50.20  ? 138 ILE A CG2 1 
ATOM   200  C CD1 . ILE A 1 107 ? 90.892  134.589 116.577 1.00 63.70  ? 138 ILE A CD1 1 
ATOM   201  N N   . LEU A 1 108 ? 93.945  139.743 116.475 1.00 51.38  ? 139 LEU A N   1 
ATOM   202  C CA  . LEU A 1 108 ? 93.934  141.085 115.914 1.00 48.03  ? 139 LEU A CA  1 
ATOM   203  C C   . LEU A 1 108 ? 93.866  140.969 114.400 1.00 49.83  ? 139 LEU A C   1 
ATOM   204  O O   . LEU A 1 108 ? 94.650  140.235 113.793 1.00 50.21  ? 139 LEU A O   1 
ATOM   205  C CB  . LEU A 1 108 ? 95.173  141.867 116.344 1.00 41.39  ? 139 LEU A CB  1 
ATOM   206  C CG  . LEU A 1 108 ? 95.223  143.347 115.988 1.00 47.38  ? 139 LEU A CG  1 
ATOM   207  C CD1 . LEU A 1 108 ? 94.010  144.055 116.556 1.00 53.25  ? 139 LEU A CD1 1 
ATOM   208  C CD2 . LEU A 1 108 ? 96.502  143.954 116.530 1.00 42.67  ? 139 LEU A CD2 1 
ATOM   209  N N   . GLU A 1 109 ? 92.916  141.677 113.796 1.00 49.03  ? 140 GLU A N   1 
ATOM   210  C CA  . GLU A 1 109 ? 92.512  141.434 112.416 1.00 52.12  ? 140 GLU A CA  1 
ATOM   211  C C   . GLU A 1 109 ? 93.503  142.060 111.443 1.00 52.22  ? 140 GLU A C   1 
ATOM   212  O O   . GLU A 1 109 ? 93.881  143.225 111.595 1.00 54.83  ? 140 GLU A O   1 
ATOM   213  C CB  . GLU A 1 109 ? 91.104  141.975 112.167 1.00 57.47  ? 140 GLU A CB  1 
ATOM   214  C CG  . GLU A 1 109 ? 90.493  141.553 110.841 1.00 62.01  ? 140 GLU A CG  1 
ATOM   215  C CD  . GLU A 1 109 ? 89.035  141.951 110.717 1.00 69.71  ? 140 GLU A CD  1 
ATOM   216  O OE1 . GLU A 1 109 ? 88.491  142.528 111.681 1.00 74.19  ? 140 GLU A OE1 1 
ATOM   217  O OE2 . GLU A 1 109 ? 88.432  141.687 109.655 1.00 71.60  ? 140 GLU A OE2 1 
ATOM   218  N N   . GLY A 1 110 ? 93.921  141.278 110.452 1.00 47.82  ? 141 GLY A N   1 
ATOM   219  C CA  . GLY A 1 110 ? 94.836  141.759 109.437 1.00 41.75  ? 141 GLY A CA  1 
ATOM   220  C C   . GLY A 1 110 ? 94.837  140.854 108.228 1.00 39.82  ? 141 GLY A C   1 
ATOM   221  O O   . GLY A 1 110 ? 94.399  139.701 108.290 1.00 40.06  ? 141 GLY A O   1 
ATOM   222  N N   . ASP A 1 111 ? 95.347  141.392 107.116 1.00 40.14  ? 142 ASP A N   1 
ATOM   223  C CA  . ASP A 1 111 ? 95.259  140.681 105.845 1.00 37.39  ? 142 ASP A CA  1 
ATOM   224  C C   . ASP A 1 111 ? 96.322  139.598 105.717 1.00 36.96  ? 142 ASP A C   1 
ATOM   225  O O   . ASP A 1 111 ? 96.037  138.505 105.215 1.00 41.55  ? 142 ASP A O   1 
ATOM   226  C CB  . ASP A 1 111 ? 95.345  141.667 104.686 1.00 36.67  ? 142 ASP A CB  1 
ATOM   227  C CG  . ASP A 1 111 ? 94.171  142.616 104.654 1.00 41.59  ? 142 ASP A CG  1 
ATOM   228  O OD1 . ASP A 1 111 ? 94.328  143.757 104.178 1.00 44.59  ? 142 ASP A OD1 1 
ATOM   229  O OD2 . ASP A 1 111 ? 93.080  142.217 105.111 1.00 41.38  ? 142 ASP A OD2 1 
ATOM   230  N N   . VAL A 1 112 ? 97.546  139.869 106.149 1.00 31.73  ? 143 VAL A N   1 
ATOM   231  C CA  . VAL A 1 112 ? 98.608  138.872 106.137 1.00 32.95  ? 143 VAL A CA  1 
ATOM   232  C C   . VAL A 1 112 ? 98.936  138.526 107.579 1.00 32.08  ? 143 VAL A C   1 
ATOM   233  O O   . VAL A 1 112 ? 99.565  139.314 108.290 1.00 36.57  ? 143 VAL A O   1 
ATOM   234  C CB  . VAL A 1 112 ? 99.844  139.370 105.374 1.00 39.80  ? 143 VAL A CB  1 
ATOM   235  C CG1 . VAL A 1 112 ? 100.923 138.310 105.361 1.00 40.24  ? 143 VAL A CG1 1 
ATOM   236  C CG2 . VAL A 1 112 ? 99.468  139.700 103.942 1.00 44.14  ? 143 VAL A CG2 1 
ATOM   237  N N   . VAL A 1 113 ? 98.518  137.345 108.004 1.00 33.04  ? 144 VAL A N   1 
ATOM   238  C CA  . VAL A 1 113 ? 98.474  136.988 109.407 1.00 35.55  ? 144 VAL A CA  1 
ATOM   239  C C   . VAL A 1 113 ? 99.848  136.560 109.893 1.00 34.39  ? 144 VAL A C   1 
ATOM   240  O O   . VAL A 1 113 ? 100.800 136.413 109.129 1.00 39.04  ? 144 VAL A O   1 
ATOM   241  C CB  . VAL A 1 113 ? 97.434  135.882 109.686 1.00 38.97  ? 144 VAL A CB  1 
ATOM   242  C CG1 . VAL A 1 113 ? 96.018  136.444 109.619 1.00 37.26  ? 144 VAL A CG1 1 
ATOM   243  C CG2 . VAL A 1 113 ? 97.607  134.747 108.699 1.00 40.72  ? 144 VAL A CG2 1 
ATOM   244  N N   . LEU A 1 114 ? 99.944  136.396 111.205 1.00 32.78  ? 145 LEU A N   1 
ATOM   245  C CA  . LEU A 1 114 ? 101.126 135.935 111.908 1.00 32.40  ? 145 LEU A CA  1 
ATOM   246  C C   . LEU A 1 114 ? 100.624 135.281 113.187 1.00 38.50  ? 145 LEU A C   1 
ATOM   247  O O   . LEU A 1 114 ? 99.503  135.545 113.621 1.00 45.55  ? 145 LEU A O   1 
ATOM   248  C CB  . LEU A 1 114 ? 102.083 137.113 112.180 1.00 34.93  ? 145 LEU A CB  1 
ATOM   249  C CG  . LEU A 1 114 ? 103.442 137.020 112.877 1.00 38.91  ? 145 LEU A CG  1 
ATOM   250  C CD1 . LEU A 1 114 ? 104.503 136.463 111.956 1.00 40.90  ? 145 LEU A CD1 1 
ATOM   251  C CD2 . LEU A 1 114 ? 103.846 138.385 113.398 1.00 38.22  ? 145 LEU A CD2 1 
ATOM   252  N N   . SER A 1 115 ? 101.418 134.395 113.768 1.00 36.53  ? 146 SER A N   1 
ATOM   253  C CA  . SER A 1 115 ? 101.046 133.766 115.024 1.00 38.56  ? 146 SER A CA  1 
ATOM   254  C C   . SER A 1 115 ? 102.226 133.830 115.972 1.00 40.26  ? 146 SER A C   1 
ATOM   255  O O   . SER A 1 115 ? 103.375 133.756 115.538 1.00 45.79  ? 146 SER A O   1 
ATOM   256  C CB  . SER A 1 115 ? 100.613 132.326 114.807 1.00 47.14  ? 146 SER A CB  1 
ATOM   257  O OG  . SER A 1 115 ? 99.456  132.274 113.994 1.00 53.13  ? 146 SER A OG  1 
ATOM   258  N N   . VAL A 1 116 ? 101.955 134.047 117.258 1.00 38.16  ? 147 VAL A N   1 
ATOM   259  C CA  . VAL A 1 116 ? 102.995 134.115 118.281 1.00 41.20  ? 147 VAL A CA  1 
ATOM   260  C C   . VAL A 1 116 ? 102.592 133.194 119.429 1.00 49.25  ? 147 VAL A C   1 
ATOM   261  O O   . VAL A 1 116 ? 101.534 133.379 120.034 1.00 53.10  ? 147 VAL A O   1 
ATOM   262  C CB  . VAL A 1 116 ? 103.220 135.559 118.787 1.00 42.90  ? 147 VAL A CB  1 
ATOM   263  C CG1 . VAL A 1 116 ? 104.110 135.576 119.986 1.00 45.39  ? 147 VAL A CG1 1 
ATOM   264  C CG2 . VAL A 1 116 ? 103.874 136.430 117.735 1.00 42.88  ? 147 VAL A CG2 1 
ATOM   265  N N   . LEU A 1 117 ? 103.425 132.203 119.733 1.00 54.47  ? 148 LEU A N   1 
ATOM   266  C CA  . LEU A 1 117 ? 103.157 131.259 120.821 1.00 57.19  ? 148 LEU A CA  1 
ATOM   267  C C   . LEU A 1 117 ? 103.944 131.729 122.042 1.00 60.00  ? 148 LEU A C   1 
ATOM   268  O O   . LEU A 1 117 ? 105.112 131.382 122.214 1.00 62.76  ? 148 LEU A O   1 
ATOM   269  C CB  . LEU A 1 117 ? 103.540 129.842 120.419 1.00 61.86  ? 148 LEU A CB  1 
ATOM   270  C CG  . LEU A 1 117 ? 103.149 128.715 121.376 1.00 71.42  ? 148 LEU A CG  1 
ATOM   271  C CD1 . LEU A 1 117 ? 101.745 128.230 121.075 1.00 74.37  ? 148 LEU A CD1 1 
ATOM   272  C CD2 . LEU A 1 117 ? 104.144 127.565 121.307 1.00 77.87  ? 148 LEU A CD2 1 
ATOM   273  N N   . THR A 1 118 ? 103.296 132.515 122.900 1.00 59.81  ? 149 THR A N   1 
ATOM   274  C CA  . THR A 1 118 ? 103.993 133.230 123.960 1.00 59.78  ? 149 THR A CA  1 
ATOM   275  C C   . THR A 1 118 ? 103.341 133.013 125.316 1.00 64.24  ? 149 THR A C   1 
ATOM   276  O O   . THR A 1 118 ? 102.194 132.571 125.422 1.00 68.52  ? 149 THR A O   1 
ATOM   277  C CB  . THR A 1 118 ? 104.035 134.729 123.688 1.00 60.68  ? 149 THR A CB  1 
ATOM   278  O OG1 . THR A 1 118 ? 104.631 135.400 124.803 1.00 61.69  ? 149 THR A OG1 1 
ATOM   279  C CG2 . THR A 1 118 ? 102.633 135.264 123.459 1.00 56.58  ? 149 THR A CG2 1 
ATOM   280  N N   . LYS A 1 119 ? 104.108 133.333 126.359 1.00 62.84  ? 150 LYS A N   1 
ATOM   281  C CA  . LYS A 1 119 ? 103.574 133.323 127.715 1.00 62.73  ? 150 LYS A CA  1 
ATOM   282  C C   . LYS A 1 119 ? 102.943 134.671 128.055 1.00 58.08  ? 150 LYS A C   1 
ATOM   283  O O   . LYS A 1 119 ? 101.969 134.738 128.815 1.00 58.08  ? 150 LYS A O   1 
ATOM   284  C CB  . LYS A 1 119 ? 104.692 132.935 128.690 1.00 60.99  ? 150 LYS A CB  1 
ATOM   285  C CG  . LYS A 1 119 ? 104.287 132.734 130.141 1.00 64.37  ? 150 LYS A CG  1 
ATOM   286  C CD  . LYS A 1 119 ? 105.475 132.337 130.993 1.00 64.27  ? 150 LYS A CD  1 
ATOM   287  C CE  . LYS A 1 119 ? 105.925 130.918 130.684 1.00 68.39  ? 150 LYS A CE  1 
ATOM   288  N NZ  . LYS A 1 119 ? 104.899 129.921 131.101 1.00 71.98  ? 150 LYS A NZ  1 
ATOM   289  N N   . ASP A 1 120 ? 103.452 135.755 127.460 1.00 56.53  ? 151 ASP A N   1 
ATOM   290  C CA  . ASP A 1 120 ? 102.914 137.095 127.663 1.00 53.95  ? 151 ASP A CA  1 
ATOM   291  C C   . ASP A 1 120 ? 102.257 137.568 126.369 1.00 52.08  ? 151 ASP A C   1 
ATOM   292  O O   . ASP A 1 120 ? 102.963 138.003 125.448 1.00 50.88  ? 151 ASP A O   1 
ATOM   293  C CB  . ASP A 1 120 ? 104.024 138.061 128.087 1.00 52.57  ? 151 ASP A CB  1 
ATOM   294  C CG  . ASP A 1 120 ? 103.492 139.418 128.512 1.00 52.03  ? 151 ASP A CG  1 
ATOM   295  O OD1 . ASP A 1 120 ? 102.316 139.511 128.919 1.00 51.72  ? 151 ASP A OD1 1 
ATOM   296  O OD2 . ASP A 1 120 ? 104.252 140.401 128.439 1.00 51.79  ? 151 ASP A OD2 1 
ATOM   297  N N   . PRO A 1 121 ? 100.927 137.510 126.244 1.00 50.13  ? 152 PRO A N   1 
ATOM   298  C CA  . PRO A 1 121 ? 100.311 137.875 124.960 1.00 44.88  ? 152 PRO A CA  1 
ATOM   299  C C   . PRO A 1 121 ? 99.966  139.344 124.833 1.00 42.84  ? 152 PRO A C   1 
ATOM   300  O O   . PRO A 1 121 ? 99.655  139.792 123.728 1.00 44.65  ? 152 PRO A O   1 
ATOM   301  C CB  . PRO A 1 121 ? 99.056  136.999 124.932 1.00 52.45  ? 152 PRO A CB  1 
ATOM   302  C CG  . PRO A 1 121 ? 98.664  136.935 126.362 1.00 57.17  ? 152 PRO A CG  1 
ATOM   303  C CD  . PRO A 1 121 ? 99.953  136.870 127.146 1.00 55.81  ? 152 PRO A CD  1 
ATOM   304  N N   . ASP A 1 122 ? 99.991  140.106 125.927 1.00 43.07  ? 153 ASP A N   1 
ATOM   305  C CA  . ASP A 1 122 ? 99.631  141.520 125.856 1.00 41.89  ? 153 ASP A CA  1 
ATOM   306  C C   . ASP A 1 122 ? 100.755 142.342 125.245 1.00 40.40  ? 153 ASP A C   1 
ATOM   307  O O   . ASP A 1 122 ? 100.509 143.379 124.620 1.00 38.46  ? 153 ASP A O   1 
ATOM   308  C CB  . ASP A 1 122 ? 99.291  142.042 127.249 1.00 47.99  ? 153 ASP A CB  1 
ATOM   309  C CG  . ASP A 1 122 ? 97.830  141.880 127.589 1.00 55.47  ? 153 ASP A CG  1 
ATOM   310  O OD1 . ASP A 1 122 ? 97.501  141.894 128.793 1.00 58.23  ? 153 ASP A OD1 1 
ATOM   311  O OD2 . ASP A 1 122 ? 97.017  141.730 126.653 1.00 53.72  ? 153 ASP A OD2 1 
ATOM   312  N N   . SER A 1 123 ? 101.995 141.887 125.415 1.00 43.32  ? 154 SER A N   1 
ATOM   313  C CA  . SER A 1 123 ? 103.142 142.568 124.827 1.00 40.23  ? 154 SER A CA  1 
ATOM   314  C C   . SER A 1 123 ? 103.305 142.222 123.354 1.00 37.79  ? 154 SER A C   1 
ATOM   315  O O   . SER A 1 123 ? 104.008 142.924 122.620 1.00 36.35  ? 154 SER A O   1 
ATOM   316  C CB  . SER A 1 123 ? 104.400 142.202 125.601 1.00 42.15  ? 154 SER A CB  1 
ATOM   317  O OG  . SER A 1 123 ? 104.490 140.800 125.748 1.00 44.79  ? 154 SER A OG  1 
ATOM   318  N N   . ALA A 1 124 ? 102.696 141.124 122.908 1.00 40.94  ? 155 ALA A N   1 
ATOM   319  C CA  . ALA A 1 124 ? 102.808 140.733 121.508 1.00 36.93  ? 155 ALA A CA  1 
ATOM   320  C C   . ALA A 1 124 ? 101.895 141.570 120.620 1.00 33.15  ? 155 ALA A C   1 
ATOM   321  O O   . ALA A 1 124 ? 102.273 141.937 119.506 1.00 32.31  ? 155 ALA A O   1 
ATOM   322  C CB  . ALA A 1 124 ? 102.503 139.244 121.353 1.00 36.42  ? 155 ALA A CB  1 
ATOM   323  N N   . LEU A 1 125 ? 100.690 141.896 121.096 1.00 32.91  ? 156 LEU A N   1 
ATOM   324  C CA  . LEU A 1 125 ? 99.777  142.687 120.274 1.00 31.58  ? 156 LEU A CA  1 
ATOM   325  C C   . LEU A 1 125 ? 100.082 144.170 120.341 1.00 34.32  ? 156 LEU A C   1 
ATOM   326  O O   . LEU A 1 125 ? 99.541  144.942 119.546 1.00 40.51  ? 156 LEU A O   1 
ATOM   327  C CB  . LEU A 1 125 ? 98.308  142.473 120.646 1.00 37.56  ? 156 LEU A CB  1 
ATOM   328  C CG  . LEU A 1 125 ? 97.448  141.271 120.244 1.00 37.18  ? 156 LEU A CG  1 
ATOM   329  C CD1 . LEU A 1 125 ? 97.799  140.014 120.948 1.00 37.51  ? 156 LEU A CD1 1 
ATOM   330  C CD2 . LEU A 1 125 ? 95.983  141.607 120.451 1.00 40.42  ? 156 LEU A CD2 1 
ATOM   331  N N   . PHE A 1 126 ? 100.897 144.600 121.303 1.00 34.28  ? 157 PHE A N   1 
ATOM   332  C CA  . PHE A 1 126 ? 101.292 146.004 121.344 1.00 35.44  ? 157 PHE A CA  1 
ATOM   333  C C   . PHE A 1 126 ? 102.300 146.323 120.253 1.00 37.57  ? 157 PHE A C   1 
ATOM   334  O O   . PHE A 1 126 ? 102.307 147.436 119.718 1.00 41.02  ? 157 PHE A O   1 
ATOM   335  C CB  . PHE A 1 126 ? 101.869 146.362 122.706 1.00 37.11  ? 157 PHE A CB  1 
ATOM   336  C CG  . PHE A 1 126 ? 102.234 147.802 122.836 1.00 38.11  ? 157 PHE A CG  1 
ATOM   337  C CD1 . PHE A 1 126 ? 101.288 148.792 122.577 1.00 39.69  ? 157 PHE A CD1 1 
ATOM   338  C CD2 . PHE A 1 126 ? 103.536 148.168 123.159 1.00 39.68  ? 157 PHE A CD2 1 
ATOM   339  C CE1 . PHE A 1 126 ? 101.624 150.138 122.680 1.00 43.57  ? 157 PHE A CE1 1 
ATOM   340  C CE2 . PHE A 1 126 ? 103.889 149.508 123.264 1.00 43.30  ? 157 PHE A CE2 1 
ATOM   341  C CZ  . PHE A 1 126 ? 102.930 150.493 123.022 1.00 44.14  ? 157 PHE A CZ  1 
ATOM   342  N N   . VAL A 1 127 ? 103.152 145.351 119.910 1.00 36.78  ? 158 VAL A N   1 
ATOM   343  C CA  . VAL A 1 127 ? 104.144 145.529 118.853 1.00 30.08  ? 158 VAL A CA  1 
ATOM   344  C C   . VAL A 1 127 ? 103.470 145.587 117.490 1.00 31.11  ? 158 VAL A C   1 
ATOM   345  O O   . VAL A 1 127 ? 103.717 146.508 116.707 1.00 35.62  ? 158 VAL A O   1 
ATOM   346  C CB  . VAL A 1 127 ? 105.194 144.408 118.933 1.00 25.91  ? 158 VAL A CB  1 
ATOM   347  C CG1 . VAL A 1 127 ? 106.165 144.477 117.778 1.00 28.66  ? 158 VAL A CG1 1 
ATOM   348  C CG2 . VAL A 1 127 ? 105.935 144.501 120.244 1.00 28.32  ? 158 VAL A CG2 1 
ATOM   349  N N   . ILE A 1 128 ? 102.510 144.692 117.250 1.00 33.09  ? 159 ILE A N   1 
ATOM   350  C CA  . ILE A 1 128 ? 101.832 144.603 115.957 1.00 33.47  ? 159 ILE A CA  1 
ATOM   351  C C   . ILE A 1 128 ? 100.794 145.725 115.809 1.00 35.27  ? 159 ILE A C   1 
ATOM   352  O O   . ILE A 1 128 ? 100.411 146.093 114.693 1.00 41.04  ? 159 ILE A O   1 
ATOM   353  C CB  . ILE A 1 128 ? 101.245 143.179 115.806 1.00 29.41  ? 159 ILE A CB  1 
ATOM   354  C CG1 . ILE A 1 128 ? 102.309 142.136 116.161 1.00 29.86  ? 159 ILE A CG1 1 
ATOM   355  C CG2 . ILE A 1 128 ? 100.769 142.828 114.394 1.00 30.44  ? 159 ILE A CG2 1 
ATOM   356  C CD1 . ILE A 1 128 ? 103.540 142.081 115.241 1.00 30.71  ? 159 ILE A CD1 1 
ATOM   357  N N   . ASN A 1 129 ? 100.372 146.337 116.918 1.00 33.70  ? 160 ASN A N   1 
ATOM   358  C CA  . ASN A 1 129 ? 99.646  147.601 116.817 1.00 36.39  ? 160 ASN A CA  1 
ATOM   359  C C   . ASN A 1 129 ? 100.582 148.730 116.403 1.00 40.75  ? 160 ASN A C   1 
ATOM   360  O O   . ASN A 1 129 ? 100.212 149.605 115.611 1.00 46.05  ? 160 ASN A O   1 
ATOM   361  C CB  . ASN A 1 129 ? 98.957  147.932 118.139 1.00 41.64  ? 160 ASN A CB  1 
ATOM   362  C CG  . ASN A 1 129 ? 98.356  149.322 118.155 1.00 46.80  ? 160 ASN A CG  1 
ATOM   363  O OD1 . ASN A 1 129 ? 98.711  150.155 118.984 1.00 49.63  ? 160 ASN A OD1 1 
ATOM   364  N ND2 . ASN A 1 129 ? 97.461  149.588 117.216 1.00 48.28  ? 160 ASN A ND2 1 
ATOM   365  N N   . ARG A 1 130 ? 101.826 148.692 116.884 1.00 41.47  ? 161 ARG A N   1 
ATOM   366  C CA  . ARG A 1 130 ? 102.752 149.785 116.608 1.00 42.53  ? 161 ARG A CA  1 
ATOM   367  C C   . ARG A 1 130 ? 103.416 149.641 115.241 1.00 44.69  ? 161 ARG A C   1 
ATOM   368  O O   . ARG A 1 130 ? 104.024 150.596 114.746 1.00 48.06  ? 161 ARG A O   1 
ATOM   369  C CB  . ARG A 1 130 ? 103.802 149.871 117.710 1.00 34.03  ? 161 ARG A CB  1 
ATOM   370  C CG  . ARG A 1 130 ? 103.304 150.531 118.969 1.00 36.57  ? 161 ARG A CG  1 
ATOM   371  C CD  . ARG A 1 130 ? 103.007 151.990 118.762 1.00 41.45  ? 161 ARG A CD  1 
ATOM   372  N NE  . ARG A 1 130 ? 101.583 152.264 118.857 1.00 42.65  ? 161 ARG A NE  1 
ATOM   373  C CZ  . ARG A 1 130 ? 101.031 153.441 118.608 1.00 47.29  ? 161 ARG A CZ  1 
ATOM   374  N NH1 . ARG A 1 130 ? 101.759 154.484 118.251 1.00 46.48  ? 161 ARG A NH1 1 
ATOM   375  N NH2 . ARG A 1 130 ? 99.716  153.576 118.724 1.00 54.23  ? 161 ARG A NH2 1 
ATOM   376  N N   . VAL A 1 131 ? 103.336 148.457 114.625 1.00 40.40  ? 162 VAL A N   1 
ATOM   377  C CA  . VAL A 1 131 ? 103.817 148.299 113.254 1.00 37.28  ? 162 VAL A CA  1 
ATOM   378  C C   . VAL A 1 131 ? 102.866 148.966 112.270 1.00 41.46  ? 162 VAL A C   1 
ATOM   379  O O   . VAL A 1 131 ? 103.293 149.760 111.420 1.00 47.31  ? 162 VAL A O   1 
ATOM   380  C CB  . VAL A 1 131 ? 104.036 146.808 112.930 1.00 36.56  ? 162 VAL A CB  1 
ATOM   381  C CG1 . VAL A 1 131 ? 104.373 146.596 111.467 1.00 43.90  ? 162 VAL A CG1 1 
ATOM   382  C CG2 . VAL A 1 131 ? 105.194 146.288 113.720 1.00 36.53  ? 162 VAL A CG2 1 
ATOM   383  N N   . ASN A 1 132 ? 101.559 148.704 112.413 1.00 41.02  ? 163 ASN A N   1 
ATOM   384  C CA  . ASN A 1 132 ? 100.573 149.098 111.406 1.00 44.83  ? 163 ASN A CA  1 
ATOM   385  C C   . ASN A 1 132 ? 100.276 150.591 111.447 1.00 49.25  ? 163 ASN A C   1 
ATOM   386  O O   . ASN A 1 132 ? 99.853  151.173 110.442 1.00 52.46  ? 163 ASN A O   1 
ATOM   387  C CB  . ASN A 1 132 ? 99.284  148.314 111.608 1.00 40.72  ? 163 ASN A CB  1 
ATOM   388  C CG  . ASN A 1 132 ? 99.526  146.849 111.748 1.00 39.95  ? 163 ASN A CG  1 
ATOM   389  O OD1 . ASN A 1 132 ? 100.626 146.368 111.498 1.00 39.21  ? 163 ASN A OD1 1 
ATOM   390  N ND2 . ASN A 1 132 ? 98.508  146.123 112.183 1.00 40.61  ? 163 ASN A ND2 1 
ATOM   391  N N   . GLN A 1 133 ? 100.492 151.226 112.596 1.00 46.83  ? 164 GLN A N   1 
ATOM   392  C CA  . GLN A 1 133 ? 100.341 152.671 112.657 1.00 49.21  ? 164 GLN A CA  1 
ATOM   393  C C   . GLN A 1 133 ? 101.574 153.371 112.106 1.00 49.79  ? 164 GLN A C   1 
ATOM   394  O O   . GLN A 1 133 ? 101.494 154.520 111.655 1.00 52.05  ? 164 GLN A O   1 
ATOM   395  C CB  . GLN A 1 133 ? 100.055 153.101 114.089 1.00 48.94  ? 164 GLN A CB  1 
ATOM   396  C CG  . GLN A 1 133 ? 98.747  152.566 114.603 1.00 49.95  ? 164 GLN A CG  1 
ATOM   397  C CD  . GLN A 1 133 ? 97.568  153.262 113.971 1.00 56.63  ? 164 GLN A CD  1 
ATOM   398  O OE1 . GLN A 1 133 ? 97.364  154.458 114.158 1.00 56.93  ? 164 GLN A OE1 1 
ATOM   399  N NE2 . GLN A 1 133 ? 96.782  152.514 113.209 1.00 59.55  ? 164 GLN A NE2 1 
ATOM   400  N N   . ALA A 1 134 ? 102.723 152.693 112.127 1.00 46.77  ? 165 ALA A N   1 
ATOM   401  C CA  . ALA A 1 134 ? 103.953 153.308 111.646 1.00 46.92  ? 165 ALA A CA  1 
ATOM   402  C C   . ALA A 1 134 ? 104.140 153.121 110.148 1.00 49.93  ? 165 ALA A C   1 
ATOM   403  O O   . ALA A 1 134 ? 104.809 153.953 109.520 1.00 53.61  ? 165 ALA A O   1 
ATOM   404  C CB  . ALA A 1 134 ? 105.159 152.741 112.391 1.00 44.94  ? 165 ALA A CB  1 
ATOM   405  N N   . ASN A 1 135 ? 103.530 152.057 109.582 1.00 48.38  ? 166 ASN A N   1 
ATOM   406  C CA  . ASN A 1 135 ? 103.761 151.529 108.222 1.00 45.07  ? 166 ASN A CA  1 
ATOM   407  C C   . ASN A 1 135 ? 105.242 151.258 107.963 1.00 46.66  ? 166 ASN A C   1 
ATOM   408  O O   . ASN A 1 135 ? 105.903 151.983 107.216 1.00 49.13  ? 166 ASN A O   1 
ATOM   409  C CB  . ASN A 1 135 ? 103.163 152.417 107.120 1.00 46.97  ? 166 ASN A CB  1 
ATOM   410  C CG  . ASN A 1 135 ? 101.710 152.112 106.849 1.00 51.42  ? 166 ASN A CG  1 
ATOM   411  O OD1 . ASN A 1 135 ? 101.295 150.955 106.861 1.00 49.62  ? 166 ASN A OD1 1 
ATOM   412  N ND2 . ASN A 1 135 ? 100.929 153.151 106.585 1.00 55.12  ? 166 ASN A ND2 1 
ATOM   413  N N   . LEU A 1 136 ? 105.776 150.243 108.653 1.00 44.98  ? 167 LEU A N   1 
ATOM   414  C CA  . LEU A 1 136 ? 107.131 149.767 108.386 1.00 48.71  ? 167 LEU A CA  1 
ATOM   415  C C   . LEU A 1 136 ? 107.272 149.158 107.000 1.00 55.01  ? 167 LEU A C   1 
ATOM   416  O O   . LEU A 1 136 ? 108.336 149.281 106.385 1.00 56.85  ? 167 LEU A O   1 
ATOM   417  C CB  . LEU A 1 136 ? 107.556 148.719 109.412 1.00 47.41  ? 167 LEU A CB  1 
ATOM   418  C CG  . LEU A 1 136 ? 107.751 149.081 110.877 1.00 47.63  ? 167 LEU A CG  1 
ATOM   419  C CD1 . LEU A 1 136 ? 108.059 147.815 111.645 1.00 43.91  ? 167 LEU A CD1 1 
ATOM   420  C CD2 . LEU A 1 136 ? 108.859 150.100 111.052 1.00 50.61  ? 167 LEU A CD2 1 
ATOM   421  N N   . ILE A 1 137 ? 106.223 148.507 106.494 1.00 53.62  ? 168 ILE A N   1 
ATOM   422  C CA  . ILE A 1 137 ? 106.256 147.874 105.188 1.00 49.47  ? 168 ILE A CA  1 
ATOM   423  C C   . ILE A 1 137 ? 105.754 148.784 104.084 1.00 50.36  ? 168 ILE A C   1 
ATOM   424  O O   . ILE A 1 137 ? 105.835 148.393 102.910 1.00 56.32  ? 168 ILE A O   1 
ATOM   425  C CB  . ILE A 1 137 ? 105.449 146.569 105.210 1.00 52.65  ? 168 ILE A CB  1 
ATOM   426  C CG1 . ILE A 1 137 ? 104.043 146.844 105.744 1.00 57.25  ? 168 ILE A CG1 1 
ATOM   427  C CG2 . ILE A 1 137 ? 106.161 145.550 106.060 1.00 50.64  ? 168 ILE A CG2 1 
ATOM   428  C CD1 . ILE A 1 137 ? 103.126 145.643 105.736 1.00 53.98  ? 168 ILE A CD1 1 
ATOM   429  N N   . MET A 1 138 ? 105.322 150.011 104.431 1.00 50.92  ? 169 MET A N   1 
ATOM   430  C CA  . MET A 1 138 ? 104.665 151.067 103.617 1.00 54.01  ? 169 MET A CA  1 
ATOM   431  C C   . MET A 1 138 ? 103.606 150.532 102.642 1.00 55.84  ? 169 MET A C   1 
ATOM   432  O O   . MET A 1 138 ? 103.550 150.885 101.464 1.00 58.32  ? 169 MET A O   1 
ATOM   433  C CB  . MET A 1 138 ? 105.690 151.996 102.923 1.00 58.94  ? 169 MET A CB  1 
ATOM   434  C CG  . MET A 1 138 ? 106.787 151.446 101.984 1.00 62.13  ? 169 MET A CG  1 
ATOM   435  S SD  . MET A 1 138 ? 107.860 152.729 101.311 1.00 74.18  ? 169 MET A SD  1 
ATOM   436  C CE  . MET A 1 138 ? 106.757 153.509 100.135 1.00 70.27  ? 169 MET A CE  1 
ATOM   437  N N   . ALA A 1 139 ? 102.729 149.689 103.183 1.00 55.68  ? 170 ALA A N   1 
ATOM   438  C CA  . ALA A 1 139 ? 101.775 148.942 102.381 1.00 59.77  ? 170 ALA A CA  1 
ATOM   439  C C   . ALA A 1 139 ? 100.352 149.303 102.780 1.00 62.26  ? 170 ALA A C   1 
ATOM   440  O O   . ALA A 1 139 ? 100.111 149.923 103.818 1.00 61.45  ? 170 ALA A O   1 
ATOM   441  C CB  . ALA A 1 139 ? 101.994 147.435 102.524 1.00 57.58  ? 170 ALA A CB  1 
ATOM   442  N N   . ASP A 1 140 ? 99.406  148.908 101.922 1.00 63.00  ? 171 ASP A N   1 
ATOM   443  C CA  . ASP A 1 140 ? 97.994  149.186 102.167 1.00 60.21  ? 171 ASP A CA  1 
ATOM   444  C C   . ASP A 1 140 ? 97.421  148.246 103.216 1.00 56.75  ? 171 ASP A C   1 
ATOM   445  O O   . ASP A 1 140 ? 96.547  148.642 103.994 1.00 61.27  ? 171 ASP A O   1 
ATOM   446  C CB  . ASP A 1 140 ? 97.212  149.073 100.856 1.00 62.11  ? 171 ASP A CB  1 
ATOM   447  C CG  . ASP A 1 140 ? 95.997  149.991 100.802 1.00 68.59  ? 171 ASP A CG  1 
ATOM   448  O OD1 . ASP A 1 140 ? 95.804  150.640 99.754  1.00 73.88  ? 171 ASP A OD1 1 
ATOM   449  O OD2 . ASP A 1 140 ? 95.227  150.067 101.779 1.00 68.55  ? 171 ASP A OD2 1 
ATOM   450  N N   . PHE A 1 141 ? 97.912  147.015 103.270 1.00 51.48  ? 172 PHE A N   1 
ATOM   451  C CA  . PHE A 1 141 ? 97.362  146.048 104.202 1.00 49.78  ? 172 PHE A CA  1 
ATOM   452  C C   . PHE A 1 141 ? 97.972  146.227 105.589 1.00 48.04  ? 172 PHE A C   1 
ATOM   453  O O   . PHE A 1 141 ? 98.862  147.050 105.811 1.00 52.76  ? 172 PHE A O   1 
ATOM   454  C CB  . PHE A 1 141 ? 97.550  144.609 103.685 1.00 48.65  ? 172 PHE A CB  1 
ATOM   455  C CG  . PHE A 1 141 ? 98.987  144.178 103.457 1.00 49.40  ? 172 PHE A CG  1 
ATOM   456  C CD1 . PHE A 1 141 ? 99.607  144.387 102.219 1.00 52.90  ? 172 PHE A CD1 1 
ATOM   457  C CD2 . PHE A 1 141 ? 99.677  143.461 104.443 1.00 47.56  ? 172 PHE A CD2 1 
ATOM   458  C CE1 . PHE A 1 141 ? 100.912 143.958 101.995 1.00 54.97  ? 172 PHE A CE1 1 
ATOM   459  C CE2 . PHE A 1 141 ? 100.982 143.037 104.234 1.00 49.11  ? 172 PHE A CE2 1 
ATOM   460  C CZ  . PHE A 1 141 ? 101.594 143.281 103.009 1.00 54.32  ? 172 PHE A CZ  1 
ATOM   461  N N   . GLU A 1 142 ? 97.477  145.433 106.530 1.00 42.66  ? 173 GLU A N   1 
ATOM   462  C CA  . GLU A 1 142 ? 97.942  145.470 107.904 1.00 39.92  ? 173 GLU A CA  1 
ATOM   463  C C   . GLU A 1 142 ? 98.244  144.055 108.363 1.00 35.26  ? 173 GLU A C   1 
ATOM   464  O O   . GLU A 1 142 ? 97.550  143.111 107.996 1.00 39.71  ? 173 GLU A O   1 
ATOM   465  C CB  . GLU A 1 142 ? 96.901  146.121 108.814 1.00 46.34  ? 173 GLU A CB  1 
ATOM   466  C CG  . GLU A 1 142 ? 96.903  147.645 108.740 1.00 50.22  ? 173 GLU A CG  1 
ATOM   467  C CD  . GLU A 1 142 ? 95.983  148.288 109.756 1.00 57.62  ? 173 GLU A CD  1 
ATOM   468  O OE1 . GLU A 1 142 ? 95.296  147.550 110.494 1.00 61.89  ? 173 GLU A OE1 1 
ATOM   469  O OE2 . GLU A 1 142 ? 95.952  149.535 109.817 1.00 55.80  ? 173 GLU A OE2 1 
ATOM   470  N N   . ILE A 1 143 ? 99.293  143.914 109.145 1.00 30.25  ? 174 ILE A N   1 
ATOM   471  C CA  . ILE A 1 143 ? 99.687  142.609 109.653 1.00 31.80  ? 174 ILE A CA  1 
ATOM   472  C C   . ILE A 1 143 ? 98.801  142.253 110.836 1.00 37.28  ? 174 ILE A C   1 
ATOM   473  O O   . ILE A 1 143 ? 98.642  143.044 111.770 1.00 42.48  ? 174 ILE A O   1 
ATOM   474  C CB  . ILE A 1 143 ? 101.175 142.616 110.043 1.00 34.78  ? 174 ILE A CB  1 
ATOM   475  C CG1 . ILE A 1 143 ? 102.033 143.030 108.849 1.00 42.99  ? 174 ILE A CG1 1 
ATOM   476  C CG2 . ILE A 1 143 ? 101.621 141.259 110.571 1.00 34.40  ? 174 ILE A CG2 1 
ATOM   477  C CD1 . ILE A 1 143 ? 101.964 142.078 107.669 1.00 42.48  ? 174 ILE A CD1 1 
ATOM   478  N N   . GLY A 1 144 ? 98.193  141.079 110.785 1.00 36.54  ? 175 GLY A N   1 
ATOM   479  C CA  . GLY A 1 144 ? 97.427  140.553 111.905 1.00 35.30  ? 175 GLY A CA  1 
ATOM   480  C C   . GLY A 1 144 ? 98.322  139.715 112.785 1.00 35.74  ? 175 GLY A C   1 
ATOM   481  O O   . GLY A 1 144 ? 99.427  139.348 112.387 1.00 38.62  ? 175 GLY A O   1 
ATOM   482  N N   . ILE A 1 145 ? 97.862  139.443 114.002 1.00 35.07  ? 176 ILE A N   1 
ATOM   483  C CA  . ILE A 1 145 ? 98.535  138.524 114.907 1.00 34.09  ? 176 ILE A CA  1 
ATOM   484  C C   . ILE A 1 145 ? 97.470  137.644 115.557 1.00 41.40  ? 176 ILE A C   1 
ATOM   485  O O   . ILE A 1 145 ? 96.396  138.129 115.931 1.00 47.25  ? 176 ILE A O   1 
ATOM   486  C CB  . ILE A 1 145 ? 99.420  139.278 115.931 1.00 31.91  ? 176 ILE A CB  1 
ATOM   487  C CG1 . ILE A 1 145 ? 100.098 138.331 116.929 1.00 34.21  ? 176 ILE A CG1 1 
ATOM   488  C CG2 . ILE A 1 145 ? 98.691  140.445 116.611 1.00 36.55  ? 176 ILE A CG2 1 
ATOM   489  C CD1 . ILE A 1 145 ? 101.072 138.987 117.828 1.00 36.06  ? 176 ILE A CD1 1 
ATOM   490  N N   . ARG A 1 146 ? 97.718  136.337 115.587 1.00 42.03  ? 177 ARG A N   1 
ATOM   491  C CA  . ARG A 1 146 ? 96.925  135.405 116.377 1.00 43.54  ? 177 ARG A CA  1 
ATOM   492  C C   . ARG A 1 146 ? 97.823  134.895 117.493 1.00 45.46  ? 177 ARG A C   1 
ATOM   493  O O   . ARG A 1 146 ? 98.440  133.836 117.369 1.00 47.01  ? 177 ARG A O   1 
ATOM   494  C CB  . ARG A 1 146 ? 96.406  134.268 115.510 1.00 46.68  ? 177 ARG A CB  1 
ATOM   495  C CG  . ARG A 1 146 ? 95.504  134.725 114.387 1.00 52.30  ? 177 ARG A CG  1 
ATOM   496  C CD  . ARG A 1 146 ? 95.113  133.570 113.493 1.00 57.48  ? 177 ARG A CD  1 
ATOM   497  N NE  . ARG A 1 146 ? 94.951  132.337 114.248 1.00 63.20  ? 177 ARG A NE  1 
ATOM   498  C CZ  . ARG A 1 146 ? 93.786  131.872 114.670 1.00 64.14  ? 177 ARG A CZ  1 
ATOM   499  N NH1 . ARG A 1 146 ? 92.657  132.512 114.418 1.00 59.47  ? 177 ARG A NH1 1 
ATOM   500  N NH2 . ARG A 1 146 ? 93.753  130.734 115.358 1.00 67.27  ? 177 ARG A NH2 1 
ATOM   501  N N   . ALA A 1 147 ? 97.892  135.642 118.591 1.00 45.49  ? 178 ALA A N   1 
ATOM   502  C CA  . ALA A 1 147 ? 98.867  135.364 119.635 1.00 45.36  ? 178 ALA A CA  1 
ATOM   503  C C   . ALA A 1 147 ? 98.279  134.429 120.678 1.00 50.41  ? 178 ALA A C   1 
ATOM   504  O O   . ALA A 1 147 ? 97.337  134.793 121.383 1.00 54.33  ? 178 ALA A O   1 
ATOM   505  C CB  . ALA A 1 147 ? 99.353  136.646 120.298 1.00 42.48  ? 178 ALA A CB  1 
ATOM   506  N N   . ILE A 1 148 ? 98.879  133.252 120.809 1.00 53.44  ? 179 ILE A N   1 
ATOM   507  C CA  . ILE A 1 148 ? 98.391  132.191 121.677 1.00 57.95  ? 179 ILE A CA  1 
ATOM   508  C C   . ILE A 1 148 ? 99.028  132.355 123.049 1.00 60.72  ? 179 ILE A C   1 
ATOM   509  O O   . ILE A 1 148 ? 100.235 132.602 123.154 1.00 62.70  ? 179 ILE A O   1 
ATOM   510  C CB  . ILE A 1 148 ? 98.703  130.806 121.086 1.00 61.15  ? 179 ILE A CB  1 
ATOM   511  C CG1 . ILE A 1 148 ? 98.542  130.827 119.564 1.00 58.11  ? 179 ILE A CG1 1 
ATOM   512  C CG2 . ILE A 1 148 ? 97.797  129.764 121.689 1.00 69.44  ? 179 ILE A CG2 1 
ATOM   513  C CD1 . ILE A 1 148 ? 98.904  129.521 118.886 1.00 63.93  ? 179 ILE A CD1 1 
ATOM   514  N N   . SER A 1 149 ? 98.218  132.231 124.095 1.00 61.65  ? 180 SER A N   1 
ATOM   515  C CA  . SER A 1 149 ? 98.697  132.326 125.465 1.00 60.38  ? 180 SER A CA  1 
ATOM   516  C C   . SER A 1 149 ? 99.231  130.974 125.911 1.00 65.30  ? 180 SER A C   1 
ATOM   517  O O   . SER A 1 149 ? 98.618  129.940 125.634 1.00 69.98  ? 180 SER A O   1 
ATOM   518  C CB  . SER A 1 149 ? 97.570  132.770 126.394 1.00 62.01  ? 180 SER A CB  1 
ATOM   519  O OG  . SER A 1 149 ? 97.043  134.019 125.995 1.00 60.93  ? 180 SER A OG  1 
ATOM   520  N N   . ILE A 1 150 ? 100.374 130.981 126.592 1.00 65.72  ? 181 ILE A N   1 
ATOM   521  C CA  . ILE A 1 150 ? 100.909 129.767 127.197 1.00 71.92  ? 181 ILE A CA  1 
ATOM   522  C C   . ILE A 1 150 ? 100.974 129.948 128.707 1.00 76.16  ? 181 ILE A C   1 
ATOM   523  O O   . ILE A 1 150 ? 101.695 130.815 129.211 1.00 75.00  ? 181 ILE A O   1 
ATOM   524  C CB  . ILE A 1 150 ? 102.291 129.405 126.621 1.00 71.96  ? 181 ILE A CB  1 
ATOM   525  C CG1 . ILE A 1 150 ? 102.184 129.057 125.136 1.00 71.58  ? 181 ILE A CG1 1 
ATOM   526  C CG2 . ILE A 1 150 ? 102.916 128.246 127.382 1.00 79.63  ? 181 ILE A CG2 1 
ATOM   527  C CD1 . ILE A 1 150 ? 101.274 127.881 124.844 1.00 76.67  ? 181 ILE A CD1 1 
ATOM   528  N N   . ASP A 1 151 ? 100.201 129.148 129.439 1.00 83.03  ? 182 ASP A N   1 
ATOM   529  C CA  . ASP A 1 151 ? 100.321 129.140 130.892 1.00 89.57  ? 182 ASP A CA  1 
ATOM   530  C C   . ASP A 1 151 ? 100.954 127.844 131.378 1.00 90.96  ? 182 ASP A C   1 
ATOM   531  O O   . ASP A 1 151 ? 101.664 127.832 132.390 1.00 90.00  ? 182 ASP A O   1 
ATOM   532  C CB  . ASP A 1 151 ? 98.951  129.355 131.534 1.00 90.85  ? 182 ASP A CB  1 
ATOM   533  C CG  . ASP A 1 151 ? 98.347  130.698 131.177 1.00 91.04  ? 182 ASP A CG  1 
ATOM   534  O OD1 . ASP A 1 151 ? 99.111  131.615 130.807 1.00 84.90  ? 182 ASP A OD1 1 
ATOM   535  O OD2 . ASP A 1 151 ? 97.109  130.839 131.263 1.00 95.04  ? 182 ASP A OD2 1 
ATOM   536  N N   . ASN A 1 152 ? 100.712 126.747 130.667 1.00 92.15  ? 183 ASN A N   1 
ATOM   537  C CA  . ASN A 1 152 ? 101.286 125.446 130.982 1.00 95.37  ? 183 ASN A CA  1 
ATOM   538  C C   . ASN A 1 152 ? 102.317 125.110 129.914 1.00 95.65  ? 183 ASN A C   1 
ATOM   539  O O   . ASN A 1 152 ? 102.040 125.247 128.718 1.00 94.19  ? 183 ASN A O   1 
ATOM   540  C CB  . ASN A 1 152 ? 100.200 124.372 131.046 1.00 97.43  ? 183 ASN A CB  1 
ATOM   541  C CG  . ASN A 1 152 ? 100.609 123.175 131.879 1.00 98.56  ? 183 ASN A CG  1 
ATOM   542  O OD1 . ASN A 1 152 ? 101.689 123.153 132.470 1.00 97.95  ? 183 ASN A OD1 1 
ATOM   543  N ND2 . ASN A 1 152 ? 99.740  122.171 131.934 1.00 101.25 ? 183 ASN A ND2 1 
ATOM   544  N N   . ALA A 1 153 ? 103.502 124.673 130.346 1.00 96.40  ? 184 ALA A N   1 
ATOM   545  C CA  . ALA A 1 153 ? 104.559 124.343 129.394 1.00 93.29  ? 184 ALA A CA  1 
ATOM   546  C C   . ALA A 1 153 ? 104.324 122.993 128.726 1.00 96.62  ? 184 ALA A C   1 
ATOM   547  O O   . ALA A 1 153 ? 104.883 122.728 127.656 1.00 95.78  ? 184 ALA A O   1 
ATOM   548  C CB  . ALA A 1 153 ? 105.918 124.358 130.093 1.00 89.91  ? 184 ALA A CB  1 
ATOM   549  N N   . SER A 1 154 ? 103.510 122.128 129.337 1.00 99.51  ? 185 SER A N   1 
ATOM   550  C CA  . SER A 1 154 ? 103.227 120.827 128.738 1.00 99.42  ? 185 SER A CA  1 
ATOM   551  C C   . SER A 1 154 ? 102.206 120.940 127.611 1.00 97.81  ? 185 SER A C   1 
ATOM   552  O O   . SER A 1 154 ? 102.141 120.068 126.735 1.00 97.14  ? 185 SER A O   1 
ATOM   553  C CB  . SER A 1 154 ? 102.744 119.851 129.810 1.00 98.43  ? 185 SER A CB  1 
ATOM   554  O OG  . SER A 1 154 ? 103.745 119.630 130.788 1.00 95.95  ? 185 SER A OG  1 
ATOM   555  N N   . LEU A 1 155 ? 101.402 122.004 127.609 1.00 95.17  ? 186 LEU A N   1 
ATOM   556  C CA  . LEU A 1 155 ? 100.444 122.234 126.535 1.00 95.31  ? 186 LEU A CA  1 
ATOM   557  C C   . LEU A 1 155 ? 101.025 123.037 125.379 1.00 95.21  ? 186 LEU A C   1 
ATOM   558  O O   . LEU A 1 155 ? 100.287 123.362 124.443 1.00 95.70  ? 186 LEU A O   1 
ATOM   559  C CB  . LEU A 1 155 ? 99.200  122.949 127.067 1.00 95.13  ? 186 LEU A CB  1 
ATOM   560  C CG  . LEU A 1 155 ? 98.364  122.224 128.118 1.00 96.12  ? 186 LEU A CG  1 
ATOM   561  C CD1 . LEU A 1 155 ? 97.295  123.150 128.668 1.00 97.98  ? 186 LEU A CD1 1 
ATOM   562  C CD2 . LEU A 1 155 ? 97.736  120.976 127.526 1.00 96.08  ? 186 LEU A CD2 1 
ATOM   563  N N   . ALA A 1 156 ? 102.316 123.375 125.426 1.00 93.66  ? 187 ALA A N   1 
ATOM   564  C CA  . ALA A 1 156 ? 102.939 124.094 124.320 1.00 91.32  ? 187 ALA A CA  1 
ATOM   565  C C   . ALA A 1 156 ? 103.205 123.166 123.143 1.00 93.60  ? 187 ALA A C   1 
ATOM   566  O O   . ALA A 1 156 ? 103.266 123.609 121.991 1.00 93.56  ? 187 ALA A O   1 
ATOM   567  C CB  . ALA A 1 156 ? 104.233 124.755 124.789 1.00 86.92  ? 187 ALA A CB  1 
ATOM   568  N N   . GLU A 1 157 ? 103.382 121.871 123.418 1.00 95.67  ? 188 GLU A N   1 
ATOM   569  C CA  . GLU A 1 157 ? 103.597 120.901 122.349 1.00 95.67  ? 188 GLU A CA  1 
ATOM   570  C C   . GLU A 1 157 ? 102.295 120.600 121.613 1.00 93.46  ? 188 GLU A C   1 
ATOM   571  O O   . GLU A 1 157 ? 102.298 120.376 120.397 1.00 91.88  ? 188 GLU A O   1 
ATOM   572  C CB  . GLU A 1 157 ? 104.210 119.624 122.932 1.00 97.94  ? 188 GLU A CB  1 
ATOM   573  C CG  . GLU A 1 157 ? 104.709 118.615 121.909 1.00 102.04 ? 188 GLU A CG  1 
ATOM   574  C CD  . GLU A 1 157 ? 105.177 117.322 122.545 1.00 106.21 ? 188 GLU A CD  1 
ATOM   575  O OE1 . GLU A 1 157 ? 105.182 117.238 123.791 1.00 105.76 ? 188 GLU A OE1 1 
ATOM   576  O OE2 . GLU A 1 157 ? 105.540 116.389 121.799 1.00 107.80 ? 188 GLU A OE2 1 
ATOM   577  N N   . ASN A 1 158 ? 101.171 120.605 122.336 1.00 92.14  ? 189 ASN A N   1 
ATOM   578  C CA  . ASN A 1 158 ? 99.872  120.377 121.711 1.00 89.39  ? 189 ASN A CA  1 
ATOM   579  C C   . ASN A 1 158 ? 99.415  121.594 120.914 1.00 90.69  ? 189 ASN A C   1 
ATOM   580  O O   . ASN A 1 158 ? 98.810  121.453 119.846 1.00 89.95  ? 189 ASN A O   1 
ATOM   581  C CB  . ASN A 1 158 ? 98.840  120.016 122.780 1.00 87.75  ? 189 ASN A CB  1 
ATOM   582  C CG  . ASN A 1 158 ? 97.454  119.798 122.208 1.00 86.86  ? 189 ASN A CG  1 
ATOM   583  O OD1 . ASN A 1 158 ? 97.292  119.186 121.153 1.00 84.50  ? 189 ASN A OD1 1 
ATOM   584  N ND2 . ASN A 1 158 ? 96.445  120.310 122.900 1.00 89.52  ? 189 ASN A ND2 1 
ATOM   585  N N   . LEU A 1 159 ? 99.720  122.797 121.407 1.00 90.97  ? 190 LEU A N   1 
ATOM   586  C CA  . LEU A 1 159 ? 99.245  124.014 120.755 1.00 89.87  ? 190 LEU A CA  1 
ATOM   587  C C   . LEU A 1 159 ? 100.088 124.371 119.540 1.00 90.54  ? 190 LEU A C   1 
ATOM   588  O O   . LEU A 1 159 ? 99.648  125.141 118.679 1.00 89.28  ? 190 LEU A O   1 
ATOM   589  C CB  . LEU A 1 159 ? 99.236  125.164 121.755 1.00 85.60  ? 190 LEU A CB  1 
ATOM   590  C CG  . LEU A 1 159 ? 97.894  125.371 122.442 1.00 87.43  ? 190 LEU A CG  1 
ATOM   591  C CD1 . LEU A 1 159 ? 97.978  126.447 123.508 1.00 88.39  ? 190 LEU A CD1 1 
ATOM   592  C CD2 . LEU A 1 159 ? 96.807  125.709 121.425 1.00 84.60  ? 190 LEU A CD2 1 
ATOM   593  N N   . LEU A 1 160 ? 101.305 123.833 119.457 1.00 89.28  ? 191 LEU A N   1 
ATOM   594  C CA  . LEU A 1 160 ? 102.142 124.080 118.291 1.00 87.48  ? 191 LEU A CA  1 
ATOM   595  C C   . LEU A 1 160 ? 101.686 123.237 117.107 1.00 85.50  ? 191 LEU A C   1 
ATOM   596  O O   . LEU A 1 160 ? 101.912 123.603 115.950 1.00 86.40  ? 191 LEU A O   1 
ATOM   597  C CB  . LEU A 1 160 ? 103.604 123.801 118.635 1.00 91.62  ? 191 LEU A CB  1 
ATOM   598  C CG  . LEU A 1 160 ? 104.705 124.369 117.740 1.00 93.34  ? 191 LEU A CG  1 
ATOM   599  C CD1 . LEU A 1 160 ? 104.459 125.833 117.398 1.00 83.54  ? 191 LEU A CD1 1 
ATOM   600  C CD2 . LEU A 1 160 ? 106.041 124.203 118.431 1.00 92.90  ? 191 LEU A CD2 1 
ATOM   601  N N   . ILE A 1 161 ? 101.056 122.092 117.384 1.00 85.69  ? 192 ILE A N   1 
ATOM   602  C CA  . ILE A 1 161 ? 100.503 121.239 116.332 1.00 85.93  ? 192 ILE A CA  1 
ATOM   603  C C   . ILE A 1 161 ? 99.268  121.886 115.709 1.00 83.55  ? 192 ILE A C   1 
ATOM   604  O O   . ILE A 1 161 ? 99.108  121.898 114.479 1.00 84.33  ? 192 ILE A O   1 
ATOM   605  C CB  . ILE A 1 161 ? 100.211 119.836 116.908 1.00 87.29  ? 192 ILE A CB  1 
ATOM   606  C CG1 . ILE A 1 161 ? 101.518 119.178 117.354 1.00 90.91  ? 192 ILE A CG1 1 
ATOM   607  C CG2 . ILE A 1 161 ? 99.513  118.918 115.909 1.00 83.88  ? 192 ILE A CG2 1 
ATOM   608  C CD1 . ILE A 1 161 ? 101.336 117.865 118.091 1.00 87.65  ? 192 ILE A CD1 1 
ATOM   609  N N   . GLN A 1 162 ? 98.418  122.497 116.543 1.00 80.79  ? 193 GLN A N   1 
ATOM   610  C CA  . GLN A 1 162 ? 97.122  122.993 116.084 1.00 78.31  ? 193 GLN A CA  1 
ATOM   611  C C   . GLN A 1 162 ? 97.250  124.293 115.299 1.00 78.44  ? 193 GLN A C   1 
ATOM   612  O O   . GLN A 1 162 ? 96.391  124.602 114.466 1.00 80.15  ? 193 GLN A O   1 
ATOM   613  C CB  . GLN A 1 162 ? 96.183  123.181 117.276 1.00 81.86  ? 193 GLN A CB  1 
ATOM   614  C CG  . GLN A 1 162 ? 95.960  121.914 118.090 1.00 89.41  ? 193 GLN A CG  1 
ATOM   615  C CD  . GLN A 1 162 ? 95.004  122.109 119.253 1.00 90.88  ? 193 GLN A CD  1 
ATOM   616  O OE1 . GLN A 1 162 ? 94.479  123.199 119.466 1.00 90.20  ? 193 GLN A OE1 1 
ATOM   617  N NE2 . GLN A 1 162 ? 94.789  121.049 120.023 1.00 88.62  ? 193 GLN A NE2 1 
ATOM   618  N N   . GLU A 1 163 ? 98.324  125.057 115.526 1.00 79.04  ? 194 GLU A N   1 
ATOM   619  C CA  . GLU A 1 163 ? 98.499  126.307 114.786 1.00 77.00  ? 194 GLU A CA  1 
ATOM   620  C C   . GLU A 1 163 ? 99.153  126.067 113.426 1.00 75.93  ? 194 GLU A C   1 
ATOM   621  O O   . GLU A 1 163 ? 98.857  126.777 112.455 1.00 74.14  ? 194 GLU A O   1 
ATOM   622  C CB  . GLU A 1 163 ? 99.296  127.308 115.628 1.00 72.38  ? 194 GLU A CB  1 
ATOM   623  C CG  . GLU A 1 163 ? 99.427  128.749 115.075 1.00 70.75  ? 194 GLU A CG  1 
ATOM   624  C CD  . GLU A 1 163 ? 98.107  129.510 114.914 1.00 71.91  ? 194 GLU A CD  1 
ATOM   625  O OE1 . GLU A 1 163 ? 97.409  129.344 113.892 1.00 69.11  ? 194 GLU A OE1 1 
ATOM   626  O OE2 . GLU A 1 163 ? 97.770  130.310 115.809 1.00 69.80  ? 194 GLU A OE2 1 
ATOM   627  N N   . VAL A 1 164 ? 100.035 125.061 113.337 1.00 77.21  ? 195 VAL A N   1 
ATOM   628  C CA  . VAL A 1 164 ? 100.541 124.585 112.047 1.00 75.34  ? 195 VAL A CA  1 
ATOM   629  C C   . VAL A 1 164 ? 99.415  123.932 111.246 1.00 76.95  ? 195 VAL A C   1 
ATOM   630  O O   . VAL A 1 164 ? 99.295  124.135 110.030 1.00 79.09  ? 195 VAL A O   1 
ATOM   631  C CB  . VAL A 1 164 ? 101.750 123.650 112.282 1.00 78.25  ? 195 VAL A CB  1 
ATOM   632  C CG1 . VAL A 1 164 ? 102.251 122.976 111.009 1.00 79.42  ? 195 VAL A CG1 1 
ATOM   633  C CG2 . VAL A 1 164 ? 102.898 124.451 112.859 1.00 77.65  ? 195 VAL A CG2 1 
ATOM   634  N N   . GLN A 1 165 ? 98.489  123.258 111.937 1.00 76.35  ? 196 GLN A N   1 
ATOM   635  C CA  . GLN A 1 165 ? 97.287  122.752 111.279 1.00 77.60  ? 196 GLN A CA  1 
ATOM   636  C C   . GLN A 1 165 ? 96.261  123.855 111.008 1.00 76.44  ? 196 GLN A C   1 
ATOM   637  O O   . GLN A 1 165 ? 95.303  123.634 110.260 1.00 79.02  ? 196 GLN A O   1 
ATOM   638  C CB  . GLN A 1 165 ? 96.662  121.637 112.114 1.00 81.56  ? 196 GLN A CB  1 
ATOM   639  C CG  . GLN A 1 165 ? 97.372  120.300 111.985 1.00 84.52  ? 196 GLN A CG  1 
ATOM   640  C CD  . GLN A 1 165 ? 96.714  119.208 112.803 1.00 90.32  ? 196 GLN A CD  1 
ATOM   641  O OE1 . GLN A 1 165 ? 95.522  119.276 113.105 1.00 91.80  ? 196 GLN A OE1 1 
ATOM   642  N NE2 . GLN A 1 165 ? 97.485  118.188 113.157 1.00 89.15  ? 196 GLN A NE2 1 
ATOM   643  N N   . PHE A 1 166 ? 96.417  125.037 111.619 1.00 73.71  ? 197 PHE A N   1 
ATOM   644  C CA  . PHE A 1 166 ? 95.551  126.160 111.263 1.00 71.78  ? 197 PHE A CA  1 
ATOM   645  C C   . PHE A 1 166 ? 96.109  126.945 110.083 1.00 71.42  ? 197 PHE A C   1 
ATOM   646  O O   . PHE A 1 166 ? 95.376  127.228 109.127 1.00 70.26  ? 197 PHE A O   1 
ATOM   647  C CB  . PHE A 1 166 ? 95.338  127.094 112.459 1.00 69.91  ? 197 PHE A CB  1 
ATOM   648  C CG  . PHE A 1 166 ? 94.148  128.020 112.309 1.00 66.25  ? 197 PHE A CG  1 
ATOM   649  C CD1 . PHE A 1 166 ? 94.306  129.322 111.815 1.00 65.70  ? 197 PHE A CD1 1 
ATOM   650  C CD2 . PHE A 1 166 ? 92.872  127.584 112.663 1.00 65.30  ? 197 PHE A CD2 1 
ATOM   651  C CE1 . PHE A 1 166 ? 93.209  130.165 111.664 1.00 64.10  ? 197 PHE A CE1 1 
ATOM   652  C CE2 . PHE A 1 166 ? 91.765  128.425 112.524 1.00 63.56  ? 197 PHE A CE2 1 
ATOM   653  C CZ  . PHE A 1 166 ? 91.940  129.716 112.024 1.00 63.07  ? 197 PHE A CZ  1 
ATOM   654  N N   . LEU A 1 167 ? 97.395  127.325 110.145 1.00 72.10  ? 198 LEU A N   1 
ATOM   655  C CA  . LEU A 1 167 ? 97.923  128.376 109.270 1.00 70.91  ? 198 LEU A CA  1 
ATOM   656  C C   . LEU A 1 167 ? 98.176  127.878 107.852 1.00 69.86  ? 198 LEU A C   1 
ATOM   657  O O   . LEU A 1 167 ? 98.269  128.684 106.918 1.00 68.34  ? 198 LEU A O   1 
ATOM   658  C CB  . LEU A 1 167 ? 99.212  128.962 109.850 1.00 69.48  ? 198 LEU A CB  1 
ATOM   659  C CG  . LEU A 1 167 ? 99.148  129.984 110.986 1.00 63.24  ? 198 LEU A CG  1 
ATOM   660  C CD1 . LEU A 1 167 ? 100.524 130.553 111.240 1.00 58.18  ? 198 LEU A CD1 1 
ATOM   661  C CD2 . LEU A 1 167 ? 98.183  131.101 110.672 1.00 60.62  ? 198 LEU A CD2 1 
ATOM   662  N N   . GLN A 1 168 ? 98.295  126.564 107.671 1.00 72.31  ? 199 GLN A N   1 
ATOM   663  C CA  . GLN A 1 168 ? 98.403  126.017 106.324 1.00 75.81  ? 199 GLN A CA  1 
ATOM   664  C C   . GLN A 1 168 ? 97.049  126.013 105.631 1.00 72.07  ? 199 GLN A C   1 
ATOM   665  O O   . GLN A 1 168 ? 96.958  126.233 104.418 1.00 68.97  ? 199 GLN A O   1 
ATOM   666  C CB  . GLN A 1 168 ? 98.976  124.602 106.378 1.00 78.27  ? 199 GLN A CB  1 
ATOM   667  C CG  . GLN A 1 168 ? 100.406 124.523 106.865 1.00 76.02  ? 199 GLN A CG  1 
ATOM   668  C CD  . GLN A 1 168 ? 100.795 123.132 107.324 1.00 78.88  ? 199 GLN A CD  1 
ATOM   669  O OE1 . GLN A 1 168 ? 101.977 122.807 107.413 1.00 80.29  ? 199 GLN A OE1 1 
ATOM   670  N NE2 . GLN A 1 168 ? 99.801  122.303 107.621 1.00 76.98  ? 199 GLN A NE2 1 
ATOM   671  N N   . GLN A 1 169 ? 95.982  125.779 106.394 1.00 70.52  ? 200 GLN A N   1 
ATOM   672  C CA  . GLN A 1 169 ? 94.690  125.495 105.784 1.00 72.53  ? 200 GLN A CA  1 
ATOM   673  C C   . GLN A 1 169 ? 93.815  126.741 105.700 1.00 73.24  ? 200 GLN A C   1 
ATOM   674  O O   . GLN A 1 169 ? 93.367  127.121 104.611 1.00 73.00  ? 200 GLN A O   1 
ATOM   675  C CB  . GLN A 1 169 ? 93.985  124.392 106.572 1.00 71.83  ? 200 GLN A CB  1 
ATOM   676  C CG  . GLN A 1 169 ? 94.855  123.164 106.796 1.00 76.21  ? 200 GLN A CG  1 
ATOM   677  C CD  . GLN A 1 169 ? 94.182  122.106 107.653 1.00 83.38  ? 200 GLN A CD  1 
ATOM   678  O OE1 . GLN A 1 169 ? 92.957  122.055 107.752 1.00 86.09  ? 200 GLN A OE1 1 
ATOM   679  N NE2 . GLN A 1 169 ? 94.987  121.253 108.279 1.00 81.52  ? 200 GLN A NE2 1 
ATOM   680  N N   . CYS A 1 170 ? 93.575  127.400 106.829 1.00 69.55  ? 201 CYS A N   1 
ATOM   681  C CA  . CYS A 1 170 ? 92.535  128.413 106.920 1.00 65.91  ? 201 CYS A CA  1 
ATOM   682  C C   . CYS A 1 170 ? 92.972  129.788 106.437 1.00 63.37  ? 201 CYS A C   1 
ATOM   683  O O   . CYS A 1 170 ? 92.111  130.633 106.174 1.00 60.65  ? 201 CYS A O   1 
ATOM   684  C CB  . CYS A 1 170 ? 92.042  128.513 108.367 1.00 67.89  ? 201 CYS A CB  1 
ATOM   685  S SG  . CYS A 1 170 ? 91.631  126.918 109.115 1.00 74.80  ? 201 CYS A SG  1 
ATOM   686  N N   . THR A 1 171 ? 94.273  130.038 106.304 1.00 64.36  ? 202 THR A N   1 
ATOM   687  C CA  . THR A 1 171 ? 94.801  131.373 106.041 1.00 57.00  ? 202 THR A CA  1 
ATOM   688  C C   . THR A 1 171 ? 95.433  131.428 104.658 1.00 58.14  ? 202 THR A C   1 
ATOM   689  O O   . THR A 1 171 ? 96.239  130.560 104.306 1.00 60.26  ? 202 THR A O   1 
ATOM   690  C CB  . THR A 1 171 ? 95.823  131.768 107.102 1.00 53.86  ? 202 THR A CB  1 
ATOM   691  O OG1 . THR A 1 171 ? 96.905  130.829 107.097 1.00 53.66  ? 202 THR A OG1 1 
ATOM   692  C CG2 . THR A 1 171 ? 95.174  131.800 108.471 1.00 59.50  ? 202 THR A CG2 1 
ATOM   693  N N   . THR A 1 172 ? 95.070  132.457 103.887 1.00 56.73  ? 203 THR A N   1 
ATOM   694  C CA  . THR A 1 172 ? 95.578  132.601 102.525 1.00 52.43  ? 203 THR A CA  1 
ATOM   695  C C   . THR A 1 172 ? 97.030  133.070 102.512 1.00 49.40  ? 203 THR A C   1 
ATOM   696  O O   . THR A 1 172 ? 97.861  132.533 101.772 1.00 53.56  ? 203 THR A O   1 
ATOM   697  C CB  . THR A 1 172 ? 94.691  133.573 101.747 1.00 50.50  ? 203 THR A CB  1 
ATOM   698  O OG1 . THR A 1 172 ? 93.316  133.242 101.968 1.00 52.37  ? 203 THR A OG1 1 
ATOM   699  C CG2 . THR A 1 172 ? 94.985  133.501 100.259 1.00 50.13  ? 203 THR A CG2 1 
ATOM   700  N N   . TYR A 1 173 ? 97.357  134.058 103.335 1.00 44.72  ? 204 TYR A N   1 
ATOM   701  C CA  . TYR A 1 173 ? 98.693  134.642 103.388 1.00 41.49  ? 204 TYR A CA  1 
ATOM   702  C C   . TYR A 1 173 ? 99.210  134.560 104.818 1.00 38.34  ? 204 TYR A C   1 
ATOM   703  O O   . TYR A 1 173 ? 99.005  135.480 105.604 1.00 41.15  ? 204 TYR A O   1 
ATOM   704  C CB  . TYR A 1 173 ? 98.665  136.087 102.913 1.00 46.10  ? 204 TYR A CB  1 
ATOM   705  C CG  . TYR A 1 173 ? 98.458  136.294 101.433 1.00 53.41  ? 204 TYR A CG  1 
ATOM   706  C CD1 . TYR A 1 173 ? 99.524  136.157 100.536 1.00 55.65  ? 204 TYR A CD1 1 
ATOM   707  C CD2 . TYR A 1 173 ? 97.203  136.655 100.933 1.00 53.70  ? 204 TYR A CD2 1 
ATOM   708  C CE1 . TYR A 1 173 ? 99.341  136.361 99.168  1.00 54.40  ? 204 TYR A CE1 1 
ATOM   709  C CE2 . TYR A 1 173 ? 97.006  136.863 99.568  1.00 56.56  ? 204 TYR A CE2 1 
ATOM   710  C CZ  . TYR A 1 173 ? 98.081  136.714 98.699  1.00 55.84  ? 204 TYR A CZ  1 
ATOM   711  O OH  . TYR A 1 173 ? 97.893  136.918 97.353  1.00 57.22  ? 204 TYR A OH  1 
ATOM   712  N N   . SER A 1 174 ? 99.880  133.472 105.157 1.00 40.50  ? 205 SER A N   1 
ATOM   713  C CA  . SER A 1 174 ? 100.458 133.354 106.485 1.00 43.42  ? 205 SER A CA  1 
ATOM   714  C C   . SER A 1 174 ? 101.939 133.684 106.437 1.00 39.75  ? 205 SER A C   1 
ATOM   715  O O   . SER A 1 174 ? 102.559 133.702 105.375 1.00 42.93  ? 205 SER A O   1 
ATOM   716  C CB  . SER A 1 174 ? 100.258 131.950 107.055 1.00 53.74  ? 205 SER A CB  1 
ATOM   717  O OG  . SER A 1 174 ? 100.654 130.951 106.130 1.00 58.35  ? 205 SER A OG  1 
ATOM   718  N N   . MET A 1 175 ? 102.508 133.958 107.608 1.00 39.04  ? 206 MET A N   1 
ATOM   719  C CA  . MET A 1 175 ? 103.940 134.210 107.702 1.00 39.87  ? 206 MET A CA  1 
ATOM   720  C C   . MET A 1 175 ? 104.652 133.164 108.547 1.00 42.71  ? 206 MET A C   1 
ATOM   721  O O   . MET A 1 175 ? 105.589 132.529 108.055 1.00 50.47  ? 206 MET A O   1 
ATOM   722  C CB  . MET A 1 175 ? 104.197 135.622 108.236 1.00 40.75  ? 206 MET A CB  1 
ATOM   723  C CG  . MET A 1 175 ? 103.780 136.701 107.257 1.00 43.47  ? 206 MET A CG  1 
ATOM   724  S SD  . MET A 1 175 ? 103.856 138.376 107.900 1.00 59.27  ? 206 MET A SD  1 
ATOM   725  C CE  . MET A 1 175 ? 105.434 138.337 108.733 1.00 50.79  ? 206 MET A CE  1 
ATOM   726  N N   . GLY A 1 176 ? 104.240 132.947 109.789 1.00 41.44  ? 207 GLY A N   1 
ATOM   727  C CA  . GLY A 1 176 ? 104.889 131.914 110.574 1.00 44.14  ? 207 GLY A CA  1 
ATOM   728  C C   . GLY A 1 176 ? 104.567 132.041 112.043 1.00 43.84  ? 207 GLY A C   1 
ATOM   729  O O   . GLY A 1 176 ? 103.892 132.976 112.476 1.00 47.35  ? 207 GLY A O   1 
ATOM   730  N N   . ILE A 1 177 ? 105.074 131.081 112.810 1.00 45.14  ? 208 ILE A N   1 
ATOM   731  C CA  . ILE A 1 177 ? 104.810 130.995 114.241 1.00 46.81  ? 208 ILE A CA  1 
ATOM   732  C C   . ILE A 1 177 ? 106.061 131.445 114.975 1.00 46.26  ? 208 ILE A C   1 
ATOM   733  O O   . ILE A 1 177 ? 107.137 130.868 114.794 1.00 50.81  ? 208 ILE A O   1 
ATOM   734  C CB  . ILE A 1 177 ? 104.392 129.578 114.689 1.00 54.13  ? 208 ILE A CB  1 
ATOM   735  C CG1 . ILE A 1 177 ? 103.058 129.099 114.089 1.00 56.29  ? 208 ILE A CG1 1 
ATOM   736  C CG2 . ILE A 1 177 ? 104.288 129.484 116.210 1.00 54.63  ? 208 ILE A CG2 1 
ATOM   737  C CD1 . ILE A 1 177 ? 103.133 128.283 112.811 1.00 60.76  ? 208 ILE A CD1 1 
ATOM   738  N N   . PHE A 1 178 ? 105.930 132.477 115.799 1.00 45.59  ? 209 PHE A N   1 
ATOM   739  C CA  . PHE A 1 178 ? 107.000 132.915 116.680 1.00 45.56  ? 209 PHE A CA  1 
ATOM   740  C C   . PHE A 1 178 ? 106.848 132.221 118.027 1.00 49.02  ? 209 PHE A C   1 
ATOM   741  O O   . PHE A 1 178 ? 105.768 132.227 118.618 1.00 52.08  ? 209 PHE A O   1 
ATOM   742  C CB  . PHE A 1 178 ? 106.968 134.430 116.853 1.00 42.19  ? 209 PHE A CB  1 
ATOM   743  C CG  . PHE A 1 178 ? 107.782 135.170 115.844 1.00 40.21  ? 209 PHE A CG  1 
ATOM   744  C CD1 . PHE A 1 178 ? 109.150 135.354 116.037 1.00 42.95  ? 209 PHE A CD1 1 
ATOM   745  C CD2 . PHE A 1 178 ? 107.178 135.681 114.698 1.00 41.23  ? 209 PHE A CD2 1 
ATOM   746  C CE1 . PHE A 1 178 ? 109.912 136.048 115.099 1.00 41.06  ? 209 PHE A CE1 1 
ATOM   747  C CE2 . PHE A 1 178 ? 107.924 136.373 113.752 1.00 42.99  ? 209 PHE A CE2 1 
ATOM   748  C CZ  . PHE A 1 178 ? 109.295 136.556 113.955 1.00 40.21  ? 209 PHE A CZ  1 
ATOM   749  N N   . VAL A 1 179 ? 107.924 131.608 118.496 1.00 49.94  ? 210 VAL A N   1 
ATOM   750  C CA  . VAL A 1 179 ? 107.940 130.847 119.737 1.00 53.88  ? 210 VAL A CA  1 
ATOM   751  C C   . VAL A 1 179 ? 108.943 131.533 120.658 1.00 57.71  ? 210 VAL A C   1 
ATOM   752  O O   . VAL A 1 179 ? 109.995 131.982 120.193 1.00 60.55  ? 210 VAL A O   1 
ATOM   753  C CB  . VAL A 1 179 ? 108.296 129.363 119.447 1.00 62.52  ? 210 VAL A CB  1 
ATOM   754  C CG1 . VAL A 1 179 ? 108.551 128.534 120.694 1.00 71.63  ? 210 VAL A CG1 1 
ATOM   755  C CG2 . VAL A 1 179 ? 107.180 128.703 118.662 1.00 60.49  ? 210 VAL A CG2 1 
ATOM   756  N N   . ASP A 1 180 ? 108.579 131.696 121.937 1.00 59.60  ? 211 ASP A N   1 
ATOM   757  C CA  . ASP A 1 180 ? 109.478 132.235 122.955 1.00 62.14  ? 211 ASP A CA  1 
ATOM   758  C C   . ASP A 1 180 ? 110.681 131.324 123.179 1.00 69.54  ? 211 ASP A C   1 
ATOM   759  O O   . ASP A 1 180 ? 110.616 130.115 122.957 1.00 78.22  ? 211 ASP A O   1 
ATOM   760  C CB  . ASP A 1 180 ? 108.740 132.411 124.281 1.00 67.90  ? 211 ASP A CB  1 
ATOM   761  C CG  . ASP A 1 180 ? 107.724 133.525 124.240 1.00 70.47  ? 211 ASP A CG  1 
ATOM   762  O OD1 . ASP A 1 180 ? 107.289 133.886 123.131 1.00 68.08  ? 211 ASP A OD1 1 
ATOM   763  O OD2 . ASP A 1 180 ? 107.360 134.042 125.316 1.00 68.96  ? 211 ASP A OD2 1 
ATOM   764  N N   . TRP A 1 181 ? 111.782 131.929 123.647 1.00 69.50  ? 212 TRP A N   1 
ATOM   765  C CA  . TRP A 1 181 ? 113.074 131.244 123.719 1.00 73.23  ? 212 TRP A CA  1 
ATOM   766  C C   . TRP A 1 181 ? 113.119 130.225 124.854 1.00 78.54  ? 212 TRP A C   1 
ATOM   767  O O   . TRP A 1 181 ? 113.928 129.290 124.828 1.00 81.41  ? 212 TRP A O   1 
ATOM   768  C CB  . TRP A 1 181 ? 114.185 132.276 123.892 1.00 68.67  ? 212 TRP A CB  1 
ATOM   769  C CG  . TRP A 1 181 ? 115.576 131.768 123.683 1.00 69.76  ? 212 TRP A CG  1 
ATOM   770  C CD1 . TRP A 1 181 ? 116.419 131.278 124.636 1.00 73.20  ? 212 TRP A CD1 1 
ATOM   771  C CD2 . TRP A 1 181 ? 116.309 131.756 122.456 1.00 73.17  ? 212 TRP A CD2 1 
ATOM   772  N NE1 . TRP A 1 181 ? 117.622 130.931 124.074 1.00 79.07  ? 212 TRP A NE1 1 
ATOM   773  C CE2 . TRP A 1 181 ? 117.582 131.218 122.736 1.00 78.97  ? 212 TRP A CE2 1 
ATOM   774  C CE3 . TRP A 1 181 ? 116.009 132.137 121.142 1.00 71.16  ? 212 TRP A CE3 1 
ATOM   775  C CZ2 . TRP A 1 181 ? 118.556 131.051 121.750 1.00 78.84  ? 212 TRP A CZ2 1 
ATOM   776  C CZ3 . TRP A 1 181 ? 116.976 131.971 120.162 1.00 74.93  ? 212 TRP A CZ3 1 
ATOM   777  C CH2 . TRP A 1 181 ? 118.235 131.431 120.473 1.00 77.84  ? 212 TRP A CH2 1 
ATOM   778  N N   . GLU A 1 182 ? 112.260 130.394 125.860 1.00 77.76  ? 213 GLU A N   1 
ATOM   779  C CA  . GLU A 1 182 ? 112.057 129.350 126.856 1.00 76.81  ? 213 GLU A CA  1 
ATOM   780  C C   . GLU A 1 182 ? 111.316 128.162 126.254 1.00 80.59  ? 213 GLU A C   1 
ATOM   781  O O   . GLU A 1 182 ? 111.572 127.007 126.612 1.00 83.93  ? 213 GLU A O   1 
ATOM   782  C CB  . GLU A 1 182 ? 111.286 129.924 128.044 1.00 76.77  ? 213 GLU A CB  1 
ATOM   783  C CG  . GLU A 1 182 ? 111.829 131.254 128.532 1.00 80.71  ? 213 GLU A CG  1 
ATOM   784  C CD  . GLU A 1 182 ? 110.751 132.137 129.129 1.00 79.89  ? 213 GLU A CD  1 
ATOM   785  O OE1 . GLU A 1 182 ? 109.560 131.774 129.029 1.00 77.72  ? 213 GLU A OE1 1 
ATOM   786  O OE2 . GLU A 1 182 ? 111.095 133.196 129.696 1.00 76.32  ? 213 GLU A OE2 1 
ATOM   787  N N   . LEU A 1 183 ? 110.389 128.430 125.330 1.00 77.53  ? 214 LEU A N   1 
ATOM   788  C CA  . LEU A 1 183 ? 109.638 127.354 124.695 1.00 77.76  ? 214 LEU A CA  1 
ATOM   789  C C   . LEU A 1 183 ? 110.304 126.874 123.411 1.00 81.11  ? 214 LEU A C   1 
ATOM   790  O O   . LEU A 1 183 ? 109.928 125.827 122.874 1.00 86.12  ? 214 LEU A O   1 
ATOM   791  C CB  . LEU A 1 183 ? 108.210 127.805 124.402 1.00 76.95  ? 214 LEU A CB  1 
ATOM   792  C CG  . LEU A 1 183 ? 107.311 128.072 125.604 1.00 82.88  ? 214 LEU A CG  1 
ATOM   793  C CD1 . LEU A 1 183 ? 106.004 128.694 125.147 1.00 79.58  ? 214 LEU A CD1 1 
ATOM   794  C CD2 . LEU A 1 183 ? 107.064 126.792 126.375 1.00 83.87  ? 214 LEU A CD2 1 
ATOM   795  N N   . TYR A 1 184 ? 111.269 127.634 122.887 1.00 79.85  ? 215 TYR A N   1 
ATOM   796  C CA  . TYR A 1 184 ? 112.000 127.178 121.708 1.00 79.99  ? 215 TYR A CA  1 
ATOM   797  C C   . TYR A 1 184 ? 113.012 126.103 122.077 1.00 86.88  ? 215 TYR A C   1 
ATOM   798  O O   . TYR A 1 184 ? 113.193 125.131 121.336 1.00 90.63  ? 215 TYR A O   1 
ATOM   799  C CB  . TYR A 1 184 ? 112.702 128.349 121.025 1.00 74.98  ? 215 TYR A CB  1 
ATOM   800  C CG  . TYR A 1 184 ? 113.151 128.054 119.617 1.00 77.02  ? 215 TYR A CG  1 
ATOM   801  C CD1 . TYR A 1 184 ? 112.239 128.088 118.560 1.00 73.33  ? 215 TYR A CD1 1 
ATOM   802  C CD2 . TYR A 1 184 ? 114.488 127.738 119.342 1.00 79.54  ? 215 TYR A CD2 1 
ATOM   803  C CE1 . TYR A 1 184 ? 112.643 127.816 117.253 1.00 74.73  ? 215 TYR A CE1 1 
ATOM   804  C CE2 . TYR A 1 184 ? 114.906 127.461 118.039 1.00 76.14  ? 215 TYR A CE2 1 
ATOM   805  C CZ  . TYR A 1 184 ? 113.976 127.504 117.006 1.00 74.79  ? 215 TYR A CZ  1 
ATOM   806  O OH  . TYR A 1 184 ? 114.380 127.235 115.720 1.00 71.54  ? 215 TYR A OH  1 
ATOM   807  N N   . LYS A 1 185 ? 113.678 126.261 123.222 1.00 85.88  ? 216 LYS A N   1 
ATOM   808  C CA  . LYS A 1 185 ? 114.690 125.295 123.637 1.00 89.36  ? 216 LYS A CA  1 
ATOM   809  C C   . LYS A 1 185 ? 114.050 124.045 124.229 1.00 92.07  ? 216 LYS A C   1 
ATOM   810  O O   . LYS A 1 185 ? 114.675 122.979 124.278 1.00 94.30  ? 216 LYS A O   1 
ATOM   811  C CB  . LYS A 1 185 ? 115.645 125.942 124.638 1.00 88.78  ? 216 LYS A CB  1 
ATOM   812  C CG  . LYS A 1 185 ? 116.649 126.886 124.003 1.00 88.86  ? 216 LYS A CG  1 
ATOM   813  C CD  . LYS A 1 185 ? 117.906 127.005 124.845 1.00 87.22  ? 216 LYS A CD  1 
ATOM   814  C CE  . LYS A 1 185 ? 119.083 127.483 124.011 1.00 85.55  ? 216 LYS A CE  1 
ATOM   815  N NZ  . LYS A 1 185 ? 120.331 127.592 124.816 1.00 84.73  ? 216 LYS A NZ  1 
ATOM   816  N N   . GLN A 1 186 ? 112.806 124.163 124.696 1.00 91.51  ? 217 GLN A N   1 
ATOM   817  C CA  . GLN A 1 186 ? 112.079 123.003 125.198 1.00 95.03  ? 217 GLN A CA  1 
ATOM   818  C C   . GLN A 1 186 ? 111.603 122.110 124.057 1.00 96.53  ? 217 GLN A C   1 
ATOM   819  O O   . GLN A 1 186 ? 111.677 120.879 124.148 1.00 99.59  ? 217 GLN A O   1 
ATOM   820  C CB  . GLN A 1 186 ? 110.896 123.471 126.047 1.00 91.92  ? 217 GLN A CB  1 
ATOM   821  C CG  . GLN A 1 186 ? 110.107 122.363 126.715 1.00 92.66  ? 217 GLN A CG  1 
ATOM   822  C CD  . GLN A 1 186 ? 108.973 122.890 127.566 1.00 94.49  ? 217 GLN A CD  1 
ATOM   823  O OE1 . GLN A 1 186 ? 108.743 124.097 127.635 1.00 94.77  ? 217 GLN A OE1 1 
ATOM   824  N NE2 . GLN A 1 186 ? 108.252 121.984 128.218 1.00 94.98  ? 217 GLN A NE2 1 
ATOM   825  N N   . LEU A 1 187 ? 111.145 122.714 122.961 1.00 94.48  ? 218 LEU A N   1 
ATOM   826  C CA  . LEU A 1 187 ? 110.446 122.007 121.895 1.00 97.09  ? 218 LEU A CA  1 
ATOM   827  C C   . LEU A 1 187 ? 111.291 121.842 120.635 1.00 100.77 ? 218 LEU A C   1 
ATOM   828  O O   . LEU A 1 187 ? 110.771 122.014 119.531 1.00 101.60 ? 218 LEU A O   1 
ATOM   829  C CB  . LEU A 1 187 ? 109.141 122.728 121.559 1.00 95.09  ? 218 LEU A CB  1 
ATOM   830  C CG  . LEU A 1 187 ? 108.100 122.791 122.675 1.00 92.28  ? 218 LEU A CG  1 
ATOM   831  C CD1 . LEU A 1 187 ? 106.962 123.717 122.286 1.00 91.84  ? 218 LEU A CD1 1 
ATOM   832  C CD2 . LEU A 1 187 ? 107.581 121.404 123.000 1.00 94.76  ? 218 LEU A CD2 1 
ATOM   833  N N   . GLU A 1 188 ? 112.583 121.520 120.779 1.00 102.30 ? 219 GLU A N   1 
ATOM   834  C CA  . GLU A 1 188 ? 113.487 121.472 119.628 1.00 105.36 ? 219 GLU A CA  1 
ATOM   835  C C   . GLU A 1 188 ? 113.250 120.240 118.754 1.00 107.87 ? 219 GLU A C   1 
ATOM   836  O O   . GLU A 1 188 ? 113.575 120.248 117.561 1.00 107.20 ? 219 GLU A O   1 
ATOM   837  C CB  . GLU A 1 188 ? 114.939 121.505 120.102 1.00 105.25 ? 219 GLU A CB  1 
ATOM   838  C CG  . GLU A 1 188 ? 115.500 122.899 120.315 1.00 104.91 ? 219 GLU A CG  1 
ATOM   839  C CD  . GLU A 1 188 ? 116.939 122.883 120.791 1.00 109.14 ? 219 GLU A CD  1 
ATOM   840  O OE1 . GLU A 1 188 ? 117.435 121.795 121.155 1.00 115.12 ? 219 GLU A OE1 1 
ATOM   841  O OE2 . GLU A 1 188 ? 117.576 123.957 120.801 1.00 105.91 ? 219 GLU A OE2 1 
ATOM   842  N N   . SER A 1 189 ? 112.685 119.175 119.325 1.00 109.56 ? 220 SER A N   1 
ATOM   843  C CA  . SER A 1 189 ? 112.393 117.981 118.537 1.00 109.79 ? 220 SER A CA  1 
ATOM   844  C C   . SER A 1 189 ? 111.094 118.138 117.751 1.00 111.70 ? 220 SER A C   1 
ATOM   845  O O   . SER A 1 189 ? 110.866 117.437 116.758 1.00 112.29 ? 220 SER A O   1 
ATOM   846  C CB  . SER A 1 189 ? 112.329 116.758 119.451 1.00 108.18 ? 220 SER A CB  1 
ATOM   847  O OG  . SER A 1 189 ? 111.457 116.986 120.544 1.00 104.99 ? 220 SER A OG  1 
ATOM   848  N N   . VAL A 1 190 ? 110.228 119.054 118.185 1.00 110.20 ? 221 VAL A N   1 
ATOM   849  C CA  . VAL A 1 190 ? 108.884 119.156 117.618 1.00 109.48 ? 221 VAL A CA  1 
ATOM   850  C C   . VAL A 1 190 ? 108.888 120.082 116.401 1.00 108.51 ? 221 VAL A C   1 
ATOM   851  O O   . VAL A 1 190 ? 108.214 119.817 115.395 1.00 108.77 ? 221 VAL A O   1 
ATOM   852  C CB  . VAL A 1 190 ? 107.910 119.616 118.726 1.00 106.50 ? 221 VAL A CB  1 
ATOM   853  C CG1 . VAL A 1 190 ? 106.473 119.811 118.232 1.00 103.42 ? 221 VAL A CG1 1 
ATOM   854  C CG2 . VAL A 1 190 ? 107.946 118.633 119.890 1.00 104.55 ? 221 VAL A CG2 1 
ATOM   855  N N   . ILE A 1 191 ? 109.702 121.146 116.459 1.00 107.01 ? 222 ILE A N   1 
ATOM   856  C CA  . ILE A 1 191 ? 109.744 122.198 115.436 1.00 106.50 ? 222 ILE A CA  1 
ATOM   857  C C   . ILE A 1 191 ? 110.381 121.700 114.138 1.00 108.39 ? 222 ILE A C   1 
ATOM   858  O O   . ILE A 1 191 ? 109.875 121.974 113.038 1.00 107.04 ? 222 ILE A O   1 
ATOM   859  C CB  . ILE A 1 191 ? 110.460 123.433 116.026 1.00 100.07 ? 222 ILE A CB  1 
ATOM   860  C CG1 . ILE A 1 191 ? 109.599 124.022 117.144 1.00 97.11  ? 222 ILE A CG1 1 
ATOM   861  C CG2 . ILE A 1 191 ? 110.841 124.485 114.992 1.00 89.79  ? 222 ILE A CG2 1 
ATOM   862  C CD1 . ILE A 1 191 ? 110.282 125.045 117.971 1.00 88.41  ? 222 ILE A CD1 1 
ATOM   863  N N   . LYS A 1 192 ? 111.437 120.886 114.246 1.00 108.79 ? 223 LYS A N   1 
ATOM   864  C CA  . LYS A 1 192 ? 112.123 120.383 113.056 1.00 109.60 ? 223 LYS A CA  1 
ATOM   865  C C   . LYS A 1 192 ? 111.338 119.266 112.370 1.00 110.89 ? 223 LYS A C   1 
ATOM   866  O O   . LYS A 1 192 ? 111.565 118.975 111.190 1.00 109.85 ? 223 LYS A O   1 
ATOM   867  C CB  . LYS A 1 192 ? 113.524 119.899 113.430 1.00 109.83 ? 223 LYS A CB  1 
ATOM   868  C CG  . LYS A 1 192 ? 114.382 120.956 114.104 1.00 111.00 ? 223 LYS A CG  1 
ATOM   869  C CD  . LYS A 1 192 ? 115.630 120.347 114.723 1.00 112.62 ? 223 LYS A CD  1 
ATOM   870  C CE  . LYS A 1 192 ? 116.501 121.415 115.367 1.00 113.75 ? 223 LYS A CE  1 
ATOM   871  N NZ  . LYS A 1 192 ? 117.687 120.831 116.051 1.00 113.41 ? 223 LYS A NZ  1 
ATOM   872  N N   . ASP A 1 193 ? 110.404 118.635 113.087 1.00 112.37 ? 224 ASP A N   1 
ATOM   873  C CA  . ASP A 1 193 ? 109.571 117.608 112.471 1.00 114.06 ? 224 ASP A CA  1 
ATOM   874  C C   . ASP A 1 193 ? 108.274 118.193 111.920 1.00 111.86 ? 224 ASP A C   1 
ATOM   875  O O   . ASP A 1 193 ? 107.589 117.545 111.119 1.00 112.37 ? 224 ASP A O   1 
ATOM   876  C CB  . ASP A 1 193 ? 109.278 116.502 113.483 1.00 114.58 ? 224 ASP A CB  1 
ATOM   877  C CG  . ASP A 1 193 ? 110.537 115.813 113.973 1.00 117.76 ? 224 ASP A CG  1 
ATOM   878  O OD1 . ASP A 1 193 ? 111.609 116.029 113.370 1.00 118.11 ? 224 ASP A OD1 1 
ATOM   879  O OD2 . ASP A 1 193 ? 110.455 115.052 114.959 1.00 120.59 ? 224 ASP A OD2 1 
ATOM   880  N N   . LEU A 1 194 ? 107.912 119.410 112.339 1.00 108.67 ? 225 LEU A N   1 
ATOM   881  C CA  . LEU A 1 194 ? 106.661 120.006 111.875 1.00 105.87 ? 225 LEU A CA  1 
ATOM   882  C C   . LEU A 1 194 ? 106.804 120.593 110.475 1.00 105.34 ? 225 LEU A C   1 
ATOM   883  O O   . LEU A 1 194 ? 105.807 120.698 109.746 1.00 103.72 ? 225 LEU A O   1 
ATOM   884  C CB  . LEU A 1 194 ? 106.184 121.074 112.856 1.00 103.80 ? 225 LEU A CB  1 
ATOM   885  C CG  . LEU A 1 194 ? 105.224 120.593 113.946 1.00 101.57 ? 225 LEU A CG  1 
ATOM   886  C CD1 . LEU A 1 194 ? 105.184 121.583 115.097 1.00 97.56  ? 225 LEU A CD1 1 
ATOM   887  C CD2 . LEU A 1 194 ? 103.831 120.370 113.378 1.00 95.92  ? 225 LEU A CD2 1 
ATOM   888  N N   . GLU A 1 195 ? 108.036 121.003 110.112 1.00 106.13 ? 226 GLU A N   1 
ATOM   889  C CA  . GLU A 1 195 ? 108.474 121.468 108.778 1.00 105.04 ? 226 GLU A CA  1 
ATOM   890  C C   . GLU A 1 195 ? 107.718 122.708 108.289 1.00 99.12  ? 226 GLU A C   1 
ATOM   891  O O   . GLU A 1 195 ? 107.385 122.822 107.109 1.00 99.47  ? 226 GLU A O   1 
ATOM   892  C CB  . GLU A 1 195 ? 108.411 120.348 107.730 1.00 107.84 ? 226 GLU A CB  1 
ATOM   893  C CG  . GLU A 1 195 ? 109.396 119.217 107.969 1.00 110.76 ? 226 GLU A CG  1 
ATOM   894  C CD  . GLU A 1 195 ? 109.150 118.028 107.062 1.00 114.70 ? 226 GLU A CD  1 
ATOM   895  O OE1 . GLU A 1 195 ? 108.201 118.082 106.252 1.00 114.32 ? 226 GLU A OE1 1 
ATOM   896  O OE2 . GLU A 1 195 ? 109.908 117.040 107.157 1.00 118.03 ? 226 GLU A OE2 1 
ATOM   897  N N   . TYR A 1 196 ? 107.442 123.637 109.200 1.00 93.61  ? 227 TYR A N   1 
ATOM   898  C CA  . TYR A 1 196 ? 106.870 124.931 108.861 1.00 84.60  ? 227 TYR A CA  1 
ATOM   899  C C   . TYR A 1 196 ? 107.849 126.012 109.298 1.00 79.00  ? 227 TYR A C   1 
ATOM   900  O O   . TYR A 1 196 ? 108.848 125.739 109.969 1.00 80.30  ? 227 TYR A O   1 
ATOM   901  C CB  . TYR A 1 196 ? 105.493 125.130 109.519 1.00 81.22  ? 227 TYR A CB  1 
ATOM   902  C CG  . TYR A 1 196 ? 104.566 126.087 108.792 1.00 75.53  ? 227 TYR A CG  1 
ATOM   903  C CD1 . TYR A 1 196 ? 104.177 125.852 107.470 1.00 78.84  ? 227 TYR A CD1 1 
ATOM   904  C CD2 . TYR A 1 196 ? 104.103 127.240 109.429 1.00 69.97  ? 227 TYR A CD2 1 
ATOM   905  C CE1 . TYR A 1 196 ? 103.330 126.743 106.802 1.00 77.80  ? 227 TYR A CE1 1 
ATOM   906  C CE2 . TYR A 1 196 ? 103.256 128.134 108.778 1.00 70.51  ? 227 TYR A CE2 1 
ATOM   907  C CZ  . TYR A 1 196 ? 102.878 127.877 107.469 1.00 73.87  ? 227 TYR A CZ  1 
ATOM   908  O OH  . TYR A 1 196 ? 102.044 128.761 106.825 1.00 69.14  ? 227 TYR A OH  1 
ATOM   909  N N   . ASN A 1 197 ? 107.566 127.250 108.891 1.00 73.86  ? 228 ASN A N   1 
ATOM   910  C CA  . ASN A 1 197 ? 108.373 128.411 109.256 1.00 66.18  ? 228 ASN A CA  1 
ATOM   911  C C   . ASN A 1 197 ? 108.087 128.760 110.710 1.00 62.28  ? 228 ASN A C   1 
ATOM   912  O O   . ASN A 1 197 ? 107.178 129.521 111.037 1.00 61.25  ? 228 ASN A O   1 
ATOM   913  C CB  . ASN A 1 197 ? 108.068 129.583 108.335 1.00 62.99  ? 228 ASN A CB  1 
ATOM   914  C CG  . ASN A 1 197 ? 108.199 129.227 106.876 1.00 69.51  ? 228 ASN A CG  1 
ATOM   915  O OD1 . ASN A 1 197 ? 107.292 129.474 106.085 1.00 68.49  ? 228 ASN A OD1 1 
ATOM   916  N ND2 . ASN A 1 197 ? 109.334 128.650 106.507 1.00 73.15  ? 228 ASN A ND2 1 
ATOM   917  N N   . ILE A 1 198 ? 108.871 128.175 111.605 1.00 63.07  ? 229 ILE A N   1 
ATOM   918  C CA  . ILE A 1 198 ? 108.767 128.471 113.027 1.00 62.34  ? 229 ILE A CA  1 
ATOM   919  C C   . ILE A 1 198 ? 110.076 129.116 113.466 1.00 62.80  ? 229 ILE A C   1 
ATOM   920  O O   . ILE A 1 198 ? 111.145 128.511 113.359 1.00 66.77  ? 229 ILE A O   1 
ATOM   921  C CB  . ILE A 1 198 ? 108.454 127.214 113.844 1.00 63.61  ? 229 ILE A CB  1 
ATOM   922  C CG1 . ILE A 1 198 ? 107.072 126.671 113.484 1.00 66.72  ? 229 ILE A CG1 1 
ATOM   923  C CG2 . ILE A 1 198 ? 108.528 127.506 115.320 1.00 61.49  ? 229 ILE A CG2 1 
ATOM   924  C CD1 . ILE A 1 198 ? 106.810 125.283 114.015 1.00 78.51  ? 229 ILE A CD1 1 
ATOM   925  N N   . TRP A 1 199 ? 109.991 130.348 113.966 1.00 56.17  ? 230 TRP A N   1 
ATOM   926  C CA  . TRP A 1 199 ? 111.145 131.152 114.307 1.00 51.41  ? 230 TRP A CA  1 
ATOM   927  C C   . TRP A 1 199 ? 111.181 131.429 115.804 1.00 54.62  ? 230 TRP A C   1 
ATOM   928  O O   . TRP A 1 199 ? 110.122 131.529 116.429 1.00 57.57  ? 230 TRP A O   1 
ATOM   929  C CB  . TRP A 1 199 ? 111.104 132.478 113.555 1.00 48.97  ? 230 TRP A CB  1 
ATOM   930  C CG  . TRP A 1 199 ? 110.993 132.318 112.093 1.00 51.58  ? 230 TRP A CG  1 
ATOM   931  C CD1 . TRP A 1 199 ? 111.802 131.579 111.288 1.00 56.18  ? 230 TRP A CD1 1 
ATOM   932  C CD2 . TRP A 1 199 ? 110.013 132.914 111.246 1.00 51.01  ? 230 TRP A CD2 1 
ATOM   933  N NE1 . TRP A 1 199 ? 111.389 131.680 109.984 1.00 59.33  ? 230 TRP A NE1 1 
ATOM   934  C CE2 . TRP A 1 199 ? 110.288 132.492 109.932 1.00 54.80  ? 230 TRP A CE2 1 
ATOM   935  C CE3 . TRP A 1 199 ? 108.927 133.766 111.470 1.00 48.96  ? 230 TRP A CE3 1 
ATOM   936  C CZ2 . TRP A 1 199 ? 109.523 132.899 108.845 1.00 53.29  ? 230 TRP A CZ2 1 
ATOM   937  C CZ3 . TRP A 1 199 ? 108.163 134.166 110.390 1.00 49.53  ? 230 TRP A CZ3 1 
ATOM   938  C CH2 . TRP A 1 199 ? 108.464 133.731 109.094 1.00 52.79  ? 230 TRP A CH2 1 
ATOM   939  N N   . PRO A 1 200 ? 112.360 131.553 116.410 1.00 57.14  ? 231 PRO A N   1 
ATOM   940  C CA  . PRO A 1 200 ? 112.411 131.916 117.827 1.00 55.53  ? 231 PRO A CA  1 
ATOM   941  C C   . PRO A 1 200 ? 112.296 133.414 118.060 1.00 54.85  ? 231 PRO A C   1 
ATOM   942  O O   . PRO A 1 200 ? 112.831 134.238 117.314 1.00 54.40  ? 231 PRO A O   1 
ATOM   943  C CB  . PRO A 1 200 ? 113.781 131.396 118.278 1.00 60.46  ? 231 PRO A CB  1 
ATOM   944  C CG  . PRO A 1 200 ? 114.606 131.410 117.059 1.00 62.96  ? 231 PRO A CG  1 
ATOM   945  C CD  . PRO A 1 200 ? 113.677 131.100 115.920 1.00 63.43  ? 231 PRO A CD  1 
ATOM   946  N N   . ILE A 1 201 ? 111.553 133.758 119.105 1.00 58.05  ? 232 ILE A N   1 
ATOM   947  C CA  . ILE A 1 201 ? 111.648 135.071 119.736 1.00 55.13  ? 232 ILE A CA  1 
ATOM   948  C C   . ILE A 1 201 ? 112.956 135.014 120.517 1.00 58.14  ? 232 ILE A C   1 
ATOM   949  O O   . ILE A 1 201 ? 113.267 133.954 121.079 1.00 64.44  ? 232 ILE A O   1 
ATOM   950  C CB  . ILE A 1 201 ? 110.411 135.357 120.610 1.00 53.16  ? 232 ILE A CB  1 
ATOM   951  C CG1 . ILE A 1 201 ? 109.173 135.440 119.718 1.00 48.66  ? 232 ILE A CG1 1 
ATOM   952  C CG2 . ILE A 1 201 ? 110.556 136.629 121.457 1.00 51.10  ? 232 ILE A CG2 1 
ATOM   953  C CD1 . ILE A 1 201 ? 107.878 135.801 120.411 1.00 48.30  ? 232 ILE A CD1 1 
ATOM   954  N N   . PRO A 1 202 ? 113.783 136.070 120.512 1.00 50.52  ? 233 PRO A N   1 
ATOM   955  C CA  . PRO A 1 202 ? 114.978 136.091 121.365 1.00 53.09  ? 233 PRO A CA  1 
ATOM   956  C C   . PRO A 1 202 ? 114.636 136.151 122.847 1.00 54.90  ? 233 PRO A C   1 
ATOM   957  O O   . PRO A 1 202 ? 113.525 136.520 123.237 1.00 53.59  ? 233 PRO A O   1 
ATOM   958  C CB  . PRO A 1 202 ? 115.707 137.362 120.919 1.00 53.41  ? 233 PRO A CB  1 
ATOM   959  C CG  . PRO A 1 202 ? 115.210 137.617 119.549 1.00 51.55  ? 233 PRO A CG  1 
ATOM   960  C CD  . PRO A 1 202 ? 113.782 137.191 119.562 1.00 49.02  ? 233 PRO A CD  1 
ATOM   961  N N   . GLY A 1 203 ? 115.607 135.752 123.665 1.00 58.05  ? 234 GLY A N   1 
ATOM   962  C CA  . GLY A 1 203 ? 115.371 135.637 125.089 1.00 55.58  ? 234 GLY A CA  1 
ATOM   963  C C   . GLY A 1 203 ? 115.312 136.984 125.782 1.00 50.51  ? 234 GLY A C   1 
ATOM   964  O O   . GLY A 1 203 ? 116.047 137.916 125.459 1.00 49.75  ? 234 GLY A O   1 
ATOM   965  N N   . THR A 1 204 ? 114.400 137.079 126.742 1.00 48.95  ? 235 THR A N   1 
ATOM   966  C CA  . THR A 1 204 ? 114.221 138.286 127.529 1.00 46.99  ? 235 THR A CA  1 
ATOM   967  C C   . THR A 1 204 ? 115.238 138.404 128.648 1.00 51.04  ? 235 THR A C   1 
ATOM   968  O O   . THR A 1 204 ? 115.386 139.488 129.216 1.00 51.57  ? 235 THR A O   1 
ATOM   969  C CB  . THR A 1 204 ? 112.814 138.332 128.113 1.00 46.54  ? 235 THR A CB  1 
ATOM   970  O OG1 . THR A 1 204 ? 112.671 137.291 129.085 1.00 54.71  ? 235 THR A OG1 1 
ATOM   971  C CG2 . THR A 1 204 ? 111.795 138.128 127.016 1.00 46.75  ? 235 THR A CG2 1 
ATOM   972  N N   . ARG A 1 205 ? 115.978 137.337 128.942 1.00 50.77  ? 236 ARG A N   1 
ATOM   973  C CA  . ARG A 1 205 ? 117.035 137.359 129.941 1.00 49.09  ? 236 ARG A CA  1 
ATOM   974  C C   . ARG A 1 205 ? 118.315 138.022 129.449 1.00 49.21  ? 236 ARG A C   1 
ATOM   975  O O   . ARG A 1 205 ? 119.225 138.230 130.247 1.00 51.32  ? 236 ARG A O   1 
ATOM   976  C CB  . ARG A 1 205 ? 117.349 135.939 130.405 1.00 53.77  ? 236 ARG A CB  1 
ATOM   977  C CG  . ARG A 1 205 ? 116.223 135.253 131.145 1.00 58.11  ? 236 ARG A CG  1 
ATOM   978  C CD  . ARG A 1 205 ? 116.595 133.813 131.441 1.00 64.91  ? 236 ARG A CD  1 
ATOM   979  N NE  . ARG A 1 205 ? 115.432 132.937 131.458 1.00 68.85  ? 236 ARG A NE  1 
ATOM   980  C CZ  . ARG A 1 205 ? 115.474 131.637 131.201 1.00 70.12  ? 236 ARG A CZ  1 
ATOM   981  N NH1 . ARG A 1 205 ? 116.608 131.029 130.897 1.00 68.72  ? 236 ARG A NH1 1 
ATOM   982  N NH2 . ARG A 1 205 ? 114.349 130.929 131.252 1.00 72.33  ? 236 ARG A NH2 1 
ATOM   983  N N   . ALA A 1 206 ? 118.425 138.352 128.167 1.00 49.62  ? 237 ALA A N   1 
ATOM   984  C CA  . ALA A 1 206 ? 119.474 139.240 127.696 1.00 47.12  ? 237 ALA A CA  1 
ATOM   985  C C   . ALA A 1 206 ? 119.171 140.699 128.001 1.00 45.41  ? 237 ALA A C   1 
ATOM   986  O O   . ALA A 1 206 ? 120.086 141.525 127.986 1.00 45.03  ? 237 ALA A O   1 
ATOM   987  C CB  . ALA A 1 206 ? 119.690 139.057 126.192 1.00 45.85  ? 237 ALA A CB  1 
ATOM   988  N N   . HIS A 1 207 ? 117.909 141.030 128.285 1.00 44.46  ? 238 HIS A N   1 
ATOM   989  C CA  . HIS A 1 207 ? 117.517 142.371 128.680 1.00 45.60  ? 238 HIS A CA  1 
ATOM   990  C C   . HIS A 1 207 ? 117.381 142.541 130.183 1.00 46.01  ? 238 HIS A C   1 
ATOM   991  O O   . HIS A 1 207 ? 117.420 143.676 130.664 1.00 47.30  ? 238 HIS A O   1 
ATOM   992  C CB  . HIS A 1 207 ? 116.178 142.751 128.029 1.00 45.63  ? 238 HIS A CB  1 
ATOM   993  C CG  . HIS A 1 207 ? 116.240 142.869 126.540 1.00 44.19  ? 238 HIS A CG  1 
ATOM   994  N ND1 . HIS A 1 207 ? 116.384 144.077 125.896 1.00 43.35  ? 238 HIS A ND1 1 
ATOM   995  C CD2 . HIS A 1 207 ? 116.177 141.929 125.569 1.00 45.96  ? 238 HIS A CD2 1 
ATOM   996  C CE1 . HIS A 1 207 ? 116.409 143.877 124.591 1.00 44.82  ? 238 HIS A CE1 1 
ATOM   997  N NE2 . HIS A 1 207 ? 116.286 142.581 124.366 1.00 48.64  ? 238 HIS A NE2 1 
ATOM   998  N N   . LEU A 1 208 ? 117.224 141.453 130.932 1.00 46.68  ? 239 LEU A N   1 
ATOM   999  C CA  . LEU A 1 208 ? 116.995 141.515 132.368 1.00 45.10  ? 239 LEU A CA  1 
ATOM   1000 C C   . LEU A 1 208 ? 118.233 141.198 133.189 1.00 44.41  ? 239 LEU A C   1 
ATOM   1001 O O   . LEU A 1 208 ? 118.505 141.894 134.166 1.00 46.20  ? 239 LEU A O   1 
ATOM   1002 C CB  . LEU A 1 208 ? 115.864 140.557 132.765 1.00 47.86  ? 239 LEU A CB  1 
ATOM   1003 C CG  . LEU A 1 208 ? 114.477 140.825 132.185 1.00 47.46  ? 239 LEU A CG  1 
ATOM   1004 C CD1 . LEU A 1 208 ? 113.459 139.889 132.803 1.00 43.42  ? 239 LEU A CD1 1 
ATOM   1005 C CD2 . LEU A 1 208 ? 114.071 142.272 132.389 1.00 47.40  ? 239 LEU A CD2 1 
ATOM   1006 N N   . PHE A 1 209 ? 118.977 140.154 132.826 1.00 44.86  ? 240 PHE A N   1 
ATOM   1007 C CA  . PHE A 1 209 ? 120.122 139.734 133.639 1.00 43.50  ? 240 PHE A CA  1 
ATOM   1008 C C   . PHE A 1 209 ? 121.351 140.650 133.560 1.00 45.01  ? 240 PHE A C   1 
ATOM   1009 O O   . PHE A 1 209 ? 122.118 140.655 134.539 1.00 49.62  ? 240 PHE A O   1 
ATOM   1010 C CB  . PHE A 1 209 ? 120.517 138.283 133.312 1.00 46.66  ? 240 PHE A CB  1 
ATOM   1011 C CG  . PHE A 1 209 ? 119.659 137.217 133.971 1.00 52.85  ? 240 PHE A CG  1 
ATOM   1012 C CD1 . PHE A 1 209 ? 118.558 137.538 134.777 1.00 50.14  ? 240 PHE A CD1 1 
ATOM   1013 C CD2 . PHE A 1 209 ? 119.966 135.873 133.761 1.00 58.86  ? 240 PHE A CD2 1 
ATOM   1014 C CE1 . PHE A 1 209 ? 117.778 136.541 135.351 1.00 49.53  ? 240 PHE A CE1 1 
ATOM   1015 C CE2 . PHE A 1 209 ? 119.199 134.865 134.341 1.00 58.27  ? 240 PHE A CE2 1 
ATOM   1016 C CZ  . PHE A 1 209 ? 118.108 135.204 135.138 1.00 54.21  ? 240 PHE A CZ  1 
ATOM   1017 N N   . PRO A 1 210 ? 121.651 141.387 132.464 1.00 44.11  ? 241 PRO A N   1 
ATOM   1018 C CA  . PRO A 1 210 ? 122.521 142.565 132.647 1.00 42.27  ? 241 PRO A CA  1 
ATOM   1019 C C   . PRO A 1 210 ? 121.945 143.660 133.527 1.00 43.00  ? 241 PRO A C   1 
ATOM   1020 O O   . PRO A 1 210 ? 122.716 144.382 134.166 1.00 49.46  ? 241 PRO A O   1 
ATOM   1021 C CB  . PRO A 1 210 ? 122.742 143.057 131.216 1.00 44.58  ? 241 PRO A CB  1 
ATOM   1022 C CG  . PRO A 1 210 ? 122.751 141.853 130.442 1.00 49.53  ? 241 PRO A CG  1 
ATOM   1023 C CD  . PRO A 1 210 ? 121.700 140.976 131.040 1.00 49.03  ? 241 PRO A CD  1 
ATOM   1024 N N   . LYS A 1 211 ? 120.624 143.830 133.566 1.00 42.97  ? 242 LYS A N   1 
ATOM   1025 C CA  . LYS A 1 211 ? 120.058 144.892 134.390 1.00 42.67  ? 242 LYS A CA  1 
ATOM   1026 C C   . LYS A 1 211 ? 119.804 144.417 135.814 1.00 41.07  ? 242 LYS A C   1 
ATOM   1027 O O   . LYS A 1 211 ? 119.546 145.234 136.702 1.00 42.57  ? 242 LYS A O   1 
ATOM   1028 C CB  . LYS A 1 211 ? 118.777 145.421 133.754 1.00 43.22  ? 242 LYS A CB  1 
ATOM   1029 C CG  . LYS A 1 211 ? 119.007 146.077 132.412 1.00 43.34  ? 242 LYS A CG  1 
ATOM   1030 C CD  . LYS A 1 211 ? 117.891 147.016 132.043 1.00 42.61  ? 242 LYS A CD  1 
ATOM   1031 C CE  . LYS A 1 211 ? 118.165 147.645 130.694 1.00 41.78  ? 242 LYS A CE  1 
ATOM   1032 N NZ  . LYS A 1 211 ? 119.533 148.224 130.622 1.00 45.17  ? 242 LYS A NZ  1 
ATOM   1033 N N   . VAL A 1 212 ? 119.833 143.100 136.049 1.00 41.82  ? 243 VAL A N   1 
ATOM   1034 C CA  . VAL A 1 212 ? 119.921 142.598 137.419 1.00 41.91  ? 243 VAL A CA  1 
ATOM   1035 C C   . VAL A 1 212 ? 121.299 142.906 137.988 1.00 39.71  ? 243 VAL A C   1 
ATOM   1036 O O   . VAL A 1 212 ? 121.428 143.477 139.078 1.00 39.76  ? 243 VAL A O   1 
ATOM   1037 C CB  . VAL A 1 212 ? 119.604 141.084 137.466 1.00 41.25  ? 243 VAL A CB  1 
ATOM   1038 C CG1 . VAL A 1 212 ? 120.065 140.441 138.758 1.00 38.75  ? 243 VAL A CG1 1 
ATOM   1039 C CG2 . VAL A 1 212 ? 118.129 140.830 137.337 1.00 38.37  ? 243 VAL A CG2 1 
ATOM   1040 N N   . ALA A 1 213 ? 122.345 142.608 137.214 1.00 38.54  ? 244 ALA A N   1 
ATOM   1041 C CA  . ALA A 1 213 ? 123.708 142.670 137.726 1.00 39.75  ? 244 ALA A CA  1 
ATOM   1042 C C   . ALA A 1 213 ? 124.245 144.094 137.751 1.00 40.80  ? 244 ALA A C   1 
ATOM   1043 O O   . ALA A 1 213 ? 125.246 144.367 138.418 1.00 44.60  ? 244 ALA A O   1 
ATOM   1044 C CB  . ALA A 1 213 ? 124.617 141.773 136.893 1.00 45.52  ? 244 ALA A CB  1 
ATOM   1045 N N   . HIS A 1 214 ? 123.616 145.012 137.016 1.00 39.71  ? 245 HIS A N   1 
ATOM   1046 C CA  . HIS A 1 214 ? 124.014 146.411 137.122 1.00 38.83  ? 245 HIS A CA  1 
ATOM   1047 C C   . HIS A 1 214 ? 123.301 147.103 138.275 1.00 40.12  ? 245 HIS A C   1 
ATOM   1048 O O   . HIS A 1 214 ? 123.816 148.076 138.835 1.00 44.08  ? 245 HIS A O   1 
ATOM   1049 C CB  . HIS A 1 214 ? 123.758 147.151 135.815 1.00 39.42  ? 245 HIS A CB  1 
ATOM   1050 C CG  . HIS A 1 214 ? 124.433 148.482 135.745 1.00 41.99  ? 245 HIS A CG  1 
ATOM   1051 N ND1 . HIS A 1 214 ? 125.798 148.617 135.630 1.00 47.03  ? 245 HIS A ND1 1 
ATOM   1052 C CD2 . HIS A 1 214 ? 123.934 149.738 135.799 1.00 44.39  ? 245 HIS A CD2 1 
ATOM   1053 C CE1 . HIS A 1 214 ? 126.110 149.900 135.602 1.00 49.17  ? 245 HIS A CE1 1 
ATOM   1054 N NE2 . HIS A 1 214 ? 124.997 150.601 135.704 1.00 46.64  ? 245 HIS A NE2 1 
ATOM   1055 N N   . LEU A 1 215 ? 122.112 146.619 138.647 1.00 39.78  ? 246 LEU A N   1 
ATOM   1056 C CA  . LEU A 1 215 ? 121.468 147.135 139.851 1.00 40.60  ? 246 LEU A CA  1 
ATOM   1057 C C   . LEU A 1 215 ? 122.127 146.587 141.104 1.00 43.50  ? 246 LEU A C   1 
ATOM   1058 O O   . LEU A 1 215 ? 122.031 147.196 142.175 1.00 40.75  ? 246 LEU A O   1 
ATOM   1059 C CB  . LEU A 1 215 ? 119.980 146.800 139.884 1.00 40.45  ? 246 LEU A CB  1 
ATOM   1060 C CG  . LEU A 1 215 ? 119.013 147.619 139.048 1.00 40.47  ? 246 LEU A CG  1 
ATOM   1061 C CD1 . LEU A 1 215 ? 117.626 147.116 139.312 1.00 43.64  ? 246 LEU A CD1 1 
ATOM   1062 C CD2 . LEU A 1 215 ? 119.129 149.059 139.394 1.00 42.24  ? 246 LEU A CD2 1 
ATOM   1063 N N   . LEU A 1 216 ? 122.755 145.415 140.999 1.00 42.82  ? 247 LEU A N   1 
ATOM   1064 C CA  . LEU A 1 216 ? 123.519 144.890 142.118 1.00 35.48  ? 247 LEU A CA  1 
ATOM   1065 C C   . LEU A 1 216 ? 124.806 145.670 142.322 1.00 38.44  ? 247 LEU A C   1 
ATOM   1066 O O   . LEU A 1 216 ? 125.160 145.953 143.462 1.00 43.68  ? 247 LEU A O   1 
ATOM   1067 C CB  . LEU A 1 216 ? 123.826 143.410 141.915 1.00 34.26  ? 247 LEU A CB  1 
ATOM   1068 C CG  . LEU A 1 216 ? 122.702 142.433 142.239 1.00 37.13  ? 247 LEU A CG  1 
ATOM   1069 C CD1 . LEU A 1 216 ? 123.135 141.015 141.928 1.00 42.36  ? 247 LEU A CD1 1 
ATOM   1070 C CD2 . LEU A 1 216 ? 122.297 142.561 143.691 1.00 37.27  ? 247 LEU A CD2 1 
ATOM   1071 N N   . HIS A 1 217 ? 125.457 146.099 141.231 1.00 40.10  ? 248 HIS A N   1 
ATOM   1072 C CA  . HIS A 1 217 ? 126.863 146.517 141.262 1.00 41.81  ? 248 HIS A CA  1 
ATOM   1073 C C   . HIS A 1 217 ? 127.050 147.885 141.920 1.00 40.75  ? 248 HIS A C   1 
ATOM   1074 O O   . HIS A 1 217 ? 128.089 148.147 142.538 1.00 43.62  ? 248 HIS A O   1 
ATOM   1075 C CB  . HIS A 1 217 ? 127.416 146.518 139.831 1.00 44.82  ? 248 HIS A CB  1 
ATOM   1076 C CG  . HIS A 1 217 ? 128.832 146.992 139.709 1.00 49.70  ? 248 HIS A CG  1 
ATOM   1077 N ND1 . HIS A 1 217 ? 129.156 148.274 139.321 1.00 50.69  ? 248 HIS A ND1 1 
ATOM   1078 C CD2 . HIS A 1 217 ? 130.007 146.355 139.919 1.00 50.58  ? 248 HIS A CD2 1 
ATOM   1079 C CE1 . HIS A 1 217 ? 130.470 148.407 139.303 1.00 48.50  ? 248 HIS A CE1 1 
ATOM   1080 N NE2 . HIS A 1 217 ? 131.010 147.257 139.660 1.00 46.98  ? 248 HIS A NE2 1 
ATOM   1081 N N   . GLN A 1 218 ? 126.039 148.743 141.864 1.00 36.95  ? 249 GLN A N   1 
ATOM   1082 C CA  . GLN A 1 218 ? 126.122 150.028 142.540 1.00 38.91  ? 249 GLN A CA  1 
ATOM   1083 C C   . GLN A 1 218 ? 125.134 150.160 143.694 1.00 40.89  ? 249 GLN A C   1 
ATOM   1084 O O   . GLN A 1 218 ? 124.817 151.282 144.099 1.00 42.91  ? 249 GLN A O   1 
ATOM   1085 C CB  . GLN A 1 218 ? 125.938 151.162 141.537 1.00 42.50  ? 249 GLN A CB  1 
ATOM   1086 C CG  . GLN A 1 218 ? 127.095 151.272 140.569 1.00 46.85  ? 249 GLN A CG  1 
ATOM   1087 C CD  . GLN A 1 218 ? 126.979 152.461 139.649 1.00 55.76  ? 249 GLN A CD  1 
ATOM   1088 O OE1 . GLN A 1 218 ? 125.998 153.199 139.689 1.00 56.91  ? 249 GLN A OE1 1 
ATOM   1089 N NE2 . GLN A 1 218 ? 127.990 152.661 138.815 1.00 57.00  ? 249 GLN A NE2 1 
ATOM   1090 N N   . MET A 1 219 ? 124.644 149.042 144.224 1.00 37.32  ? 250 MET A N   1 
ATOM   1091 C CA  . MET A 1 219 ? 123.822 149.047 145.423 1.00 33.40  ? 250 MET A CA  1 
ATOM   1092 C C   . MET A 1 219 ? 124.684 149.361 146.647 1.00 33.55  ? 250 MET A C   1 
ATOM   1093 O O   . MET A 1 219 ? 125.766 148.799 146.790 1.00 38.41  ? 250 MET A O   1 
ATOM   1094 C CB  . MET A 1 219 ? 123.143 147.688 145.575 1.00 34.41  ? 250 MET A CB  1 
ATOM   1095 C CG  . MET A 1 219 ? 122.701 147.311 146.970 1.00 37.42  ? 250 MET A CG  1 
ATOM   1096 S SD  . MET A 1 219 ? 121.436 146.045 146.982 1.00 41.72  ? 250 MET A SD  1 
ATOM   1097 C CE  . MET A 1 219 ? 120.938 146.132 148.693 1.00 31.39  ? 250 MET A CE  1 
ATOM   1098 N N   . PRO A 1 220 ? 124.259 150.297 147.506 1.00 31.25  ? 251 PRO A N   1 
ATOM   1099 C CA  . PRO A 1 220 ? 125.030 150.598 148.725 1.00 32.73  ? 251 PRO A CA  1 
ATOM   1100 C C   . PRO A 1 220 ? 124.983 149.466 149.743 1.00 36.53  ? 251 PRO A C   1 
ATOM   1101 O O   . PRO A 1 220 ? 124.012 148.713 149.817 1.00 39.77  ? 251 PRO A O   1 
ATOM   1102 C CB  . PRO A 1 220 ? 124.351 151.860 149.263 1.00 32.79  ? 251 PRO A CB  1 
ATOM   1103 C CG  . PRO A 1 220 ? 123.722 152.471 148.073 1.00 34.55  ? 251 PRO A CG  1 
ATOM   1104 C CD  . PRO A 1 220 ? 123.208 151.303 147.294 1.00 34.54  ? 251 PRO A CD  1 
ATOM   1105 N N   . TRP A 1 221 ? 126.051 149.355 150.529 1.00 35.97  ? 252 TRP A N   1 
ATOM   1106 C CA  . TRP A 1 221 ? 126.313 148.176 151.336 1.00 35.80  ? 252 TRP A CA  1 
ATOM   1107 C C   . TRP A 1 221 ? 127.273 148.567 152.449 1.00 40.32  ? 252 TRP A C   1 
ATOM   1108 O O   . TRP A 1 221 ? 127.882 149.638 152.422 1.00 40.75  ? 252 TRP A O   1 
ATOM   1109 C CB  . TRP A 1 221 ? 126.885 147.057 150.453 1.00 38.55  ? 252 TRP A CB  1 
ATOM   1110 C CG  . TRP A 1 221 ? 126.776 145.661 150.971 1.00 40.38  ? 252 TRP A CG  1 
ATOM   1111 C CD1 . TRP A 1 221 ? 127.696 144.980 151.709 1.00 42.33  ? 252 TRP A CD1 1 
ATOM   1112 C CD2 . TRP A 1 221 ? 125.692 144.760 150.757 1.00 40.37  ? 252 TRP A CD2 1 
ATOM   1113 N NE1 . TRP A 1 221 ? 127.246 143.716 151.983 1.00 42.86  ? 252 TRP A NE1 1 
ATOM   1114 C CE2 . TRP A 1 221 ? 126.016 143.554 151.407 1.00 42.02  ? 252 TRP A CE2 1 
ATOM   1115 C CE3 . TRP A 1 221 ? 124.472 144.858 150.083 1.00 40.29  ? 252 TRP A CE3 1 
ATOM   1116 C CZ2 . TRP A 1 221 ? 125.165 142.452 151.404 1.00 41.34  ? 252 TRP A CZ2 1 
ATOM   1117 C CZ3 . TRP A 1 221 ? 123.624 143.764 150.081 1.00 39.47  ? 252 TRP A CZ3 1 
ATOM   1118 C CH2 . TRP A 1 221 ? 123.976 142.576 150.737 1.00 38.92  ? 252 TRP A CH2 1 
ATOM   1119 N N   . GLY A 1 222 ? 127.400 147.699 153.447 1.00 47.57  ? 253 GLY A N   1 
ATOM   1120 C CA  . GLY A 1 222 ? 128.392 147.864 154.492 1.00 50.76  ? 253 GLY A CA  1 
ATOM   1121 C C   . GLY A 1 222 ? 129.741 147.315 154.082 1.00 52.22  ? 253 GLY A C   1 
ATOM   1122 O O   . GLY A 1 222 ? 129.952 146.903 152.936 1.00 52.64  ? 253 GLY A O   1 
ATOM   1123 N N   . GLU A 1 223 ? 130.675 147.297 155.032 1.00 56.42  ? 254 GLU A N   1 
ATOM   1124 C CA  . GLU A 1 223 ? 132.031 146.834 154.767 1.00 62.28  ? 254 GLU A CA  1 
ATOM   1125 C C   . GLU A 1 223 ? 132.249 145.383 155.177 1.00 57.62  ? 254 GLU A C   1 
ATOM   1126 O O   . GLU A 1 223 ? 133.350 145.027 155.611 1.00 61.75  ? 254 GLU A O   1 
ATOM   1127 C CB  . GLU A 1 223 ? 133.050 147.736 155.464 1.00 67.22  ? 254 GLU A CB  1 
ATOM   1128 C CG  . GLU A 1 223 ? 133.221 149.100 154.818 1.00 66.65  ? 254 GLU A CG  1 
ATOM   1129 C CD  . GLU A 1 223 ? 134.460 149.822 155.310 1.00 71.98  ? 254 GLU A CD  1 
ATOM   1130 O OE1 . GLU A 1 223 ? 135.129 149.299 156.226 1.00 70.97  ? 254 GLU A OE1 1 
ATOM   1131 O OE2 . GLU A 1 223 ? 134.770 150.908 154.778 1.00 79.91  ? 254 GLU A OE2 1 
ATOM   1132 N N   . LYS A 1 224 ? 131.229 144.542 155.058 1.00 51.61  ? 255 LYS A N   1 
ATOM   1133 C CA  . LYS A 1 224 ? 131.338 143.126 155.370 1.00 51.93  ? 255 LYS A CA  1 
ATOM   1134 C C   . LYS A 1 224 ? 131.120 142.318 154.101 1.00 47.74  ? 255 LYS A C   1 
ATOM   1135 O O   . LYS A 1 224 ? 130.137 142.533 153.388 1.00 49.42  ? 255 LYS A O   1 
ATOM   1136 C CB  . LYS A 1 224 ? 130.321 142.721 156.436 1.00 57.32  ? 255 LYS A CB  1 
ATOM   1137 C CG  . LYS A 1 224 ? 130.661 143.209 157.832 1.00 60.69  ? 255 LYS A CG  1 
ATOM   1138 C CD  . LYS A 1 224 ? 129.469 143.085 158.766 1.00 59.16  ? 255 LYS A CD  1 
ATOM   1139 C CE  . LYS A 1 224 ? 129.919 142.859 160.198 1.00 64.39  ? 255 LYS A CE  1 
ATOM   1140 N NZ  . LYS A 1 224 ? 128.966 143.451 161.175 1.00 62.72  ? 255 LYS A NZ  1 
ATOM   1141 N N   . ILE A 1 225 ? 132.042 141.401 153.815 1.00 45.55  ? 256 ILE A N   1 
ATOM   1142 C CA  . ILE A 1 225 ? 131.871 140.529 152.664 1.00 44.36  ? 256 ILE A CA  1 
ATOM   1143 C C   . ILE A 1 225 ? 131.013 139.344 153.086 1.00 45.02  ? 256 ILE A C   1 
ATOM   1144 O O   . ILE A 1 225 ? 131.300 138.660 154.074 1.00 50.15  ? 256 ILE A O   1 
ATOM   1145 C CB  . ILE A 1 225 ? 133.224 140.060 152.091 1.00 47.80  ? 256 ILE A CB  1 
ATOM   1146 C CG1 . ILE A 1 225 ? 134.177 141.234 151.833 1.00 48.83  ? 256 ILE A CG1 1 
ATOM   1147 C CG2 . ILE A 1 225 ? 133.021 139.350 150.769 1.00 46.59  ? 256 ILE A CG2 1 
ATOM   1148 C CD1 . ILE A 1 225 ? 135.334 141.365 152.832 1.00 48.67  ? 256 ILE A CD1 1 
ATOM   1149 N N   . ALA A 1 226 ? 129.943 139.102 152.340 1.00 42.37  ? 257 ALA A N   1 
ATOM   1150 C CA  . ALA A 1 226 ? 128.949 138.111 152.714 1.00 40.50  ? 257 ALA A CA  1 
ATOM   1151 C C   . ALA A 1 226 ? 129.029 136.903 151.793 1.00 42.47  ? 257 ALA A C   1 
ATOM   1152 O O   . ALA A 1 226 ? 129.643 136.943 150.727 1.00 46.22  ? 257 ALA A O   1 
ATOM   1153 C CB  . ALA A 1 226 ? 127.543 138.706 152.681 1.00 36.34  ? 257 ALA A CB  1 
ATOM   1154 N N   . SER A 1 227 ? 128.403 135.817 152.232 1.00 39.18  ? 258 SER A N   1 
ATOM   1155 C CA  . SER A 1 227 ? 128.408 134.565 151.492 1.00 37.29  ? 258 SER A CA  1 
ATOM   1156 C C   . SER A 1 227 ? 127.175 134.462 150.609 1.00 37.21  ? 258 SER A C   1 
ATOM   1157 O O   . SER A 1 227 ? 126.047 134.556 151.099 1.00 41.66  ? 258 SER A O   1 
ATOM   1158 C CB  . SER A 1 227 ? 128.451 133.396 152.467 1.00 41.48  ? 258 SER A CB  1 
ATOM   1159 O OG  . SER A 1 227 ? 128.216 132.177 151.798 1.00 45.72  ? 258 SER A OG  1 
ATOM   1160 N N   . VAL A 1 228 ? 127.379 134.242 149.315 1.00 38.16  ? 259 VAL A N   1 
ATOM   1161 C CA  . VAL A 1 228 ? 126.299 134.294 148.335 1.00 37.17  ? 259 VAL A CA  1 
ATOM   1162 C C   . VAL A 1 228 ? 125.936 132.875 147.925 1.00 37.64  ? 259 VAL A C   1 
ATOM   1163 O O   . VAL A 1 228 ? 126.768 132.139 147.383 1.00 39.71  ? 259 VAL A O   1 
ATOM   1164 C CB  . VAL A 1 228 ? 126.677 135.140 147.115 1.00 38.87  ? 259 VAL A CB  1 
ATOM   1165 C CG1 . VAL A 1 228 ? 125.536 135.177 146.130 1.00 38.17  ? 259 VAL A CG1 1 
ATOM   1166 C CG2 . VAL A 1 228 ? 127.008 136.531 147.546 1.00 37.94  ? 259 VAL A CG2 1 
ATOM   1167 N N   . GLU A 1 229 ? 124.686 132.499 148.173 1.00 37.89  ? 260 GLU A N   1 
ATOM   1168 C CA  . GLU A 1 229 ? 124.106 131.248 147.704 1.00 40.01  ? 260 GLU A CA  1 
ATOM   1169 C C   . GLU A 1 229 ? 122.938 131.588 146.792 1.00 39.98  ? 260 GLU A C   1 
ATOM   1170 O O   . GLU A 1 229 ? 122.037 132.326 147.190 1.00 42.21  ? 260 GLU A O   1 
ATOM   1171 C CB  . GLU A 1 229 ? 123.644 130.389 148.878 1.00 41.58  ? 260 GLU A CB  1 
ATOM   1172 C CG  . GLU A 1 229 ? 122.825 129.179 148.482 1.00 47.27  ? 260 GLU A CG  1 
ATOM   1173 C CD  . GLU A 1 229 ? 122.670 128.190 149.614 1.00 56.03  ? 260 GLU A CD  1 
ATOM   1174 O OE1 . GLU A 1 229 ? 123.108 128.498 150.742 1.00 62.00  ? 260 GLU A OE1 1 
ATOM   1175 O OE2 . GLU A 1 229 ? 122.102 127.104 149.380 1.00 57.10  ? 260 GLU A OE2 1 
ATOM   1176 N N   . ILE A 1 230 ? 122.944 131.052 145.578 1.00 40.64  ? 261 ILE A N   1 
ATOM   1177 C CA  . ILE A 1 230 ? 122.012 131.456 144.534 1.00 39.94  ? 261 ILE A CA  1 
ATOM   1178 C C   . ILE A 1 230 ? 121.064 130.306 144.234 1.00 43.00  ? 261 ILE A C   1 
ATOM   1179 O O   . ILE A 1 230 ? 121.500 129.226 143.823 1.00 49.65  ? 261 ILE A O   1 
ATOM   1180 C CB  . ILE A 1 230 ? 122.770 131.890 143.271 1.00 40.47  ? 261 ILE A CB  1 
ATOM   1181 C CG1 . ILE A 1 230 ? 123.664 133.086 143.592 1.00 43.34  ? 261 ILE A CG1 1 
ATOM   1182 C CG2 . ILE A 1 230 ? 121.806 132.183 142.140 1.00 42.13  ? 261 ILE A CG2 1 
ATOM   1183 C CD1 . ILE A 1 230 ? 124.459 133.615 142.433 1.00 48.27  ? 261 ILE A CD1 1 
ATOM   1184 N N   . ALA A 1 231 ? 119.768 130.543 144.419 1.00 42.63  ? 262 ALA A N   1 
ATOM   1185 C CA  . ALA A 1 231 ? 118.732 129.568 144.110 1.00 47.69  ? 262 ALA A CA  1 
ATOM   1186 C C   . ALA A 1 231 ? 118.082 129.945 142.790 1.00 48.24  ? 262 ALA A C   1 
ATOM   1187 O O   . ALA A 1 231 ? 117.718 131.104 142.588 1.00 49.47  ? 262 ALA A O   1 
ATOM   1188 C CB  . ALA A 1 231 ? 117.685 129.497 145.221 1.00 49.07  ? 262 ALA A CB  1 
ATOM   1189 N N   . THR A 1 232 ? 117.951 128.978 141.885 1.00 50.01  ? 263 THR A N   1 
ATOM   1190 C CA  . THR A 1 232 ? 117.444 129.240 140.545 1.00 53.42  ? 263 THR A CA  1 
ATOM   1191 C C   . THR A 1 232 ? 116.373 128.227 140.182 1.00 55.87  ? 263 THR A C   1 
ATOM   1192 O O   . THR A 1 232 ? 116.300 127.151 140.777 1.00 58.78  ? 263 THR A O   1 
ATOM   1193 C CB  . THR A 1 232 ? 118.545 129.167 139.492 1.00 57.82  ? 263 THR A CB  1 
ATOM   1194 O OG1 . THR A 1 232 ? 119.379 128.036 139.757 1.00 58.28  ? 263 THR A OG1 1 
ATOM   1195 C CG2 . THR A 1 232 ? 119.389 130.425 139.469 1.00 57.61  ? 263 THR A CG2 1 
ATOM   1196 N N   . GLU A 1 233 ? 115.545 128.576 139.196 1.00 58.67  ? 264 GLU A N   1 
ATOM   1197 C CA  . GLU A 1 233 ? 114.561 127.624 138.696 1.00 62.06  ? 264 GLU A CA  1 
ATOM   1198 C C   . GLU A 1 233 ? 115.186 126.584 137.774 1.00 63.52  ? 264 GLU A C   1 
ATOM   1199 O O   . GLU A 1 233 ? 114.779 125.420 137.804 1.00 64.55  ? 264 GLU A O   1 
ATOM   1200 C CB  . GLU A 1 233 ? 113.431 128.352 137.972 1.00 64.31  ? 264 GLU A CB  1 
ATOM   1201 C CG  . GLU A 1 233 ? 112.498 129.106 138.894 1.00 65.15  ? 264 GLU A CG  1 
ATOM   1202 C CD  . GLU A 1 233 ? 111.208 128.357 139.174 1.00 72.38  ? 264 GLU A CD  1 
ATOM   1203 O OE1 . GLU A 1 233 ? 111.208 127.110 139.098 1.00 71.69  ? 264 GLU A OE1 1 
ATOM   1204 O OE2 . GLU A 1 233 ? 110.194 129.016 139.484 1.00 73.35  ? 264 GLU A OE2 1 
ATOM   1205 N N   . THR A 1 234 ? 116.129 126.987 136.918 1.00 63.53  ? 265 THR A N   1 
ATOM   1206 C CA  . THR A 1 234 ? 116.882 126.083 136.052 1.00 67.31  ? 265 THR A CA  1 
ATOM   1207 C C   . THR A 1 234 ? 118.350 126.481 136.080 1.00 67.91  ? 265 THR A C   1 
ATOM   1208 O O   . THR A 1 234 ? 118.697 127.571 136.531 1.00 68.60  ? 265 THR A O   1 
ATOM   1209 C CB  . THR A 1 234 ? 116.399 126.102 134.587 1.00 69.04  ? 265 THR A CB  1 
ATOM   1210 O OG1 . THR A 1 234 ? 116.317 127.454 134.120 1.00 68.50  ? 265 THR A OG1 1 
ATOM   1211 C CG2 . THR A 1 234 ? 115.059 125.390 134.401 1.00 71.77  ? 265 THR A CG2 1 
ATOM   1212 N N   . LEU A 1 235 ? 119.216 125.607 135.558 1.00 68.34  ? 266 LEU A N   1 
ATOM   1213 C CA  . LEU A 1 235 ? 120.637 125.948 135.503 1.00 70.17  ? 266 LEU A CA  1 
ATOM   1214 C C   . LEU A 1 235 ? 120.991 126.865 134.341 1.00 71.80  ? 266 LEU A C   1 
ATOM   1215 O O   . LEU A 1 235 ? 122.118 127.369 134.298 1.00 74.13  ? 266 LEU A O   1 
ATOM   1216 C CB  . LEU A 1 235 ? 121.534 124.716 135.401 1.00 71.83  ? 266 LEU A CB  1 
ATOM   1217 C CG  . LEU A 1 235 ? 121.902 123.844 136.598 1.00 70.06  ? 266 LEU A CG  1 
ATOM   1218 C CD1 . LEU A 1 235 ? 120.784 122.946 137.081 1.00 68.21  ? 266 LEU A CD1 1 
ATOM   1219 C CD2 . LEU A 1 235 ? 123.135 123.054 136.241 1.00 70.62  ? 266 LEU A CD2 1 
ATOM   1220 N N   . GLU A 1 236 ? 120.077 127.076 133.392 1.00 72.83  ? 267 GLU A N   1 
ATOM   1221 C CA  . GLU A 1 236 ? 120.330 128.055 132.341 1.00 74.10  ? 267 GLU A CA  1 
ATOM   1222 C C   . GLU A 1 236 ? 120.187 129.476 132.872 1.00 71.15  ? 267 GLU A C   1 
ATOM   1223 O O   . GLU A 1 236 ? 120.794 130.408 132.338 1.00 71.23  ? 267 GLU A O   1 
ATOM   1224 C CB  . GLU A 1 236 ? 119.387 127.817 131.165 1.00 77.87  ? 267 GLU A CB  1 
ATOM   1225 C CG  . GLU A 1 236 ? 119.641 126.513 130.430 1.00 82.80  ? 267 GLU A CG  1 
ATOM   1226 C CD  . GLU A 1 236 ? 118.680 126.295 129.282 1.00 88.93  ? 267 GLU A CD  1 
ATOM   1227 O OE1 . GLU A 1 236 ? 117.737 127.100 129.136 1.00 88.35  ? 267 GLU A OE1 1 
ATOM   1228 O OE2 . GLU A 1 236 ? 118.861 125.317 128.527 1.00 91.09  ? 267 GLU A OE2 1 
ATOM   1229 N N   . MET A 1 237 ? 119.394 129.660 133.932 1.00 69.66  ? 268 MET A N   1 
ATOM   1230 C CA  . MET A 1 237 ? 119.314 130.967 134.572 1.00 67.43  ? 268 MET A CA  1 
ATOM   1231 C C   . MET A 1 237 ? 120.531 131.239 135.447 1.00 68.92  ? 268 MET A C   1 
ATOM   1232 O O   . MET A 1 237 ? 120.817 132.395 135.770 1.00 70.64  ? 268 MET A O   1 
ATOM   1233 C CB  . MET A 1 237 ? 118.027 131.087 135.384 1.00 64.93  ? 268 MET A CB  1 
ATOM   1234 C CG  . MET A 1 237 ? 116.783 131.088 134.524 1.00 69.96  ? 268 MET A CG  1 
ATOM   1235 S SD  . MET A 1 237 ? 115.248 131.156 135.453 1.00 83.20  ? 268 MET A SD  1 
ATOM   1236 C CE  . MET A 1 237 ? 115.327 132.838 136.057 1.00 65.90  ? 268 MET A CE  1 
ATOM   1237 N N   . TYR A 1 238 ? 121.241 130.191 135.874 1.00 69.45  ? 269 TYR A N   1 
ATOM   1238 C CA  . TYR A 1 238 ? 122.467 130.404 136.637 1.00 68.05  ? 269 TYR A CA  1 
ATOM   1239 C C   . TYR A 1 238 ? 123.643 130.715 135.719 1.00 68.17  ? 269 TYR A C   1 
ATOM   1240 O O   . TYR A 1 238 ? 124.549 131.468 136.091 1.00 67.71  ? 269 TYR A O   1 
ATOM   1241 C CB  . TYR A 1 238 ? 122.784 129.188 137.507 1.00 67.31  ? 269 TYR A CB  1 
ATOM   1242 C CG  . TYR A 1 238 ? 123.915 129.436 138.487 1.00 69.01  ? 269 TYR A CG  1 
ATOM   1243 C CD1 . TYR A 1 238 ? 123.706 130.198 139.637 1.00 65.62  ? 269 TYR A CD1 1 
ATOM   1244 C CD2 . TYR A 1 238 ? 125.198 128.925 138.250 1.00 68.58  ? 269 TYR A CD2 1 
ATOM   1245 C CE1 . TYR A 1 238 ? 124.746 130.438 140.536 1.00 64.17  ? 269 TYR A CE1 1 
ATOM   1246 C CE2 . TYR A 1 238 ? 126.244 129.163 139.138 1.00 64.57  ? 269 TYR A CE2 1 
ATOM   1247 C CZ  . TYR A 1 238 ? 126.003 129.919 140.277 1.00 64.13  ? 269 TYR A CZ  1 
ATOM   1248 O OH  . TYR A 1 238 ? 127.018 130.156 141.170 1.00 65.00  ? 269 TYR A OH  1 
ATOM   1249 N N   . ASN A 1 239 ? 123.665 130.108 134.529 1.00 69.34  ? 270 ASN A N   1 
ATOM   1250 C CA  . ASN A 1 239 ? 124.778 130.315 133.606 1.00 70.56  ? 270 ASN A CA  1 
ATOM   1251 C C   . ASN A 1 239 ? 124.694 131.682 132.943 1.00 68.81  ? 270 ASN A C   1 
ATOM   1252 O O   . ASN A 1 239 ? 125.718 132.291 132.618 1.00 69.56  ? 270 ASN A O   1 
ATOM   1253 C CB  . ASN A 1 239 ? 124.800 129.213 132.545 1.00 72.39  ? 270 ASN A CB  1 
ATOM   1254 C CG  . ASN A 1 239 ? 125.273 127.881 133.092 1.00 75.00  ? 270 ASN A CG  1 
ATOM   1255 O OD1 . ASN A 1 239 ? 126.461 127.685 133.341 1.00 75.03  ? 270 ASN A OD1 1 
ATOM   1256 N ND2 . ASN A 1 239 ? 124.344 126.948 133.259 1.00 76.67  ? 270 ASN A ND2 1 
ATOM   1257 N N   . GLU A 1 240 ? 123.476 132.188 132.748 1.00 67.48  ? 271 GLU A N   1 
ATOM   1258 C CA  . GLU A 1 240 ? 123.316 133.499 132.132 1.00 67.31  ? 271 GLU A CA  1 
ATOM   1259 C C   . GLU A 1 240 ? 123.446 134.617 133.158 1.00 66.64  ? 271 GLU A C   1 
ATOM   1260 O O   . GLU A 1 240 ? 123.695 135.770 132.791 1.00 70.55  ? 271 GLU A O   1 
ATOM   1261 C CB  . GLU A 1 240 ? 121.975 133.579 131.406 1.00 66.65  ? 271 GLU A CB  1 
ATOM   1262 C CG  . GLU A 1 240 ? 121.909 132.706 130.165 1.00 73.97  ? 271 GLU A CG  1 
ATOM   1263 C CD  . GLU A 1 240 ? 120.600 132.849 129.424 1.00 79.08  ? 271 GLU A CD  1 
ATOM   1264 O OE1 . GLU A 1 240 ? 119.868 133.818 129.702 1.00 70.31  ? 271 GLU A OE1 1 
ATOM   1265 O OE2 . GLU A 1 240 ? 120.302 131.991 128.566 1.00 84.63  ? 271 GLU A OE2 1 
ATOM   1266 N N   . PHE A 1 241 ? 123.278 134.304 134.445 1.00 65.02  ? 272 PHE A N   1 
ATOM   1267 C CA  . PHE A 1 241 ? 123.463 135.335 135.460 1.00 63.68  ? 272 PHE A CA  1 
ATOM   1268 C C   . PHE A 1 241 ? 124.937 135.559 135.764 1.00 66.72  ? 272 PHE A C   1 
ATOM   1269 O O   . PHE A 1 241 ? 125.380 136.708 135.860 1.00 67.06  ? 272 PHE A O   1 
ATOM   1270 C CB  . PHE A 1 241 ? 122.719 134.986 136.746 1.00 59.01  ? 272 PHE A CB  1 
ATOM   1271 C CG  . PHE A 1 241 ? 122.982 135.951 137.870 1.00 58.34  ? 272 PHE A CG  1 
ATOM   1272 C CD1 . PHE A 1 241 ? 122.701 137.315 137.722 1.00 55.50  ? 272 PHE A CD1 1 
ATOM   1273 C CD2 . PHE A 1 241 ? 123.527 135.498 139.071 1.00 59.75  ? 272 PHE A CD2 1 
ATOM   1274 C CE1 . PHE A 1 241 ? 122.965 138.208 138.753 1.00 53.15  ? 272 PHE A CE1 1 
ATOM   1275 C CE2 . PHE A 1 241 ? 123.784 136.390 140.114 1.00 59.52  ? 272 PHE A CE2 1 
ATOM   1276 C CZ  . PHE A 1 241 ? 123.498 137.743 139.949 1.00 56.50  ? 272 PHE A CZ  1 
ATOM   1277 N N   . MET A 1 242 ? 125.714 134.487 135.938 1.00 67.43  ? 273 MET A N   1 
ATOM   1278 C CA  . MET A 1 242 ? 127.102 134.685 136.338 1.00 67.57  ? 273 MET A CA  1 
ATOM   1279 C C   . MET A 1 242 ? 128.000 134.983 135.147 1.00 69.68  ? 273 MET A C   1 
ATOM   1280 O O   . MET A 1 242 ? 129.157 135.373 135.332 1.00 71.01  ? 273 MET A O   1 
ATOM   1281 C CB  . MET A 1 242 ? 127.617 133.488 137.130 1.00 66.35  ? 273 MET A CB  1 
ATOM   1282 C CG  . MET A 1 242 ? 126.680 133.066 138.237 1.00 65.30  ? 273 MET A CG  1 
ATOM   1283 S SD  . MET A 1 242 ? 127.147 133.843 139.793 1.00 69.44  ? 273 MET A SD  1 
ATOM   1284 C CE  . MET A 1 242 ? 128.635 132.956 140.191 1.00 68.74  ? 273 MET A CE  1 
ATOM   1285 N N   . GLU A 1 243 ? 127.501 134.791 133.925 1.00 69.30  ? 274 GLU A N   1 
ATOM   1286 C CA  . GLU A 1 243 ? 128.105 135.456 132.779 1.00 70.04  ? 274 GLU A CA  1 
ATOM   1287 C C   . GLU A 1 243 ? 127.896 136.961 132.861 1.00 69.15  ? 274 GLU A C   1 
ATOM   1288 O O   . GLU A 1 243 ? 128.798 137.739 132.536 1.00 70.55  ? 274 GLU A O   1 
ATOM   1289 C CB  . GLU A 1 243 ? 127.522 134.914 131.478 1.00 71.28  ? 274 GLU A CB  1 
ATOM   1290 C CG  . GLU A 1 243 ? 128.337 135.270 130.248 1.00 76.43  ? 274 GLU A CG  1 
ATOM   1291 C CD  . GLU A 1 243 ? 127.549 135.116 128.964 1.00 79.41  ? 274 GLU A CD  1 
ATOM   1292 O OE1 . GLU A 1 243 ? 126.344 134.793 129.039 1.00 76.09  ? 274 GLU A OE1 1 
ATOM   1293 O OE2 . GLU A 1 243 ? 128.134 135.319 127.879 1.00 82.68  ? 274 GLU A OE2 1 
ATOM   1294 N N   . ALA A 1 244 ? 126.708 137.387 133.298 1.00 66.11  ? 275 ALA A N   1 
ATOM   1295 C CA  . ALA A 1 244 ? 126.426 138.813 133.422 1.00 64.66  ? 275 ALA A CA  1 
ATOM   1296 C C   . ALA A 1 244 ? 127.056 139.395 134.679 1.00 65.03  ? 275 ALA A C   1 
ATOM   1297 O O   . ALA A 1 244 ? 127.283 140.607 134.763 1.00 66.55  ? 275 ALA A O   1 
ATOM   1298 C CB  . ALA A 1 244 ? 124.919 139.048 133.423 1.00 59.36  ? 275 ALA A CB  1 
ATOM   1299 N N   . ALA A 1 245 ? 127.328 138.552 135.676 1.00 66.15  ? 276 ALA A N   1 
ATOM   1300 C CA  . ALA A 1 245 ? 128.041 139.017 136.860 1.00 65.74  ? 276 ALA A CA  1 
ATOM   1301 C C   . ALA A 1 245 ? 129.530 139.162 136.581 1.00 65.89  ? 276 ALA A C   1 
ATOM   1302 O O   . ALA A 1 245 ? 130.210 139.976 137.215 1.00 68.31  ? 276 ALA A O   1 
ATOM   1303 C CB  . ALA A 1 245 ? 127.807 138.064 138.030 1.00 66.83  ? 276 ALA A CB  1 
ATOM   1304 N N   . ARG A 1 246 ? 130.054 138.370 135.641 1.00 65.14  ? 277 ARG A N   1 
ATOM   1305 C CA  . ARG A 1 246 ? 131.469 138.446 135.290 1.00 66.38  ? 277 ARG A CA  1 
ATOM   1306 C C   . ARG A 1 246 ? 131.762 139.692 134.467 1.00 67.89  ? 277 ARG A C   1 
ATOM   1307 O O   . ARG A 1 246 ? 132.868 140.239 134.528 1.00 68.77  ? 277 ARG A O   1 
ATOM   1308 C CB  . ARG A 1 246 ? 131.879 137.185 134.526 1.00 69.91  ? 277 ARG A CB  1 
ATOM   1309 C CG  . ARG A 1 246 ? 133.368 136.838 134.522 1.00 70.51  ? 277 ARG A CG  1 
ATOM   1310 C CD  . ARG A 1 246 ? 134.072 137.268 133.228 1.00 73.31  ? 277 ARG A CD  1 
ATOM   1311 N NE  . ARG A 1 246 ? 133.236 137.092 132.044 1.00 76.25  ? 277 ARG A NE  1 
ATOM   1312 C CZ  . ARG A 1 246 ? 133.104 135.961 131.365 1.00 82.05  ? 277 ARG A CZ  1 
ATOM   1313 N NH1 . ARG A 1 246 ? 133.750 134.862 131.716 1.00 89.33  ? 277 ARG A NH1 1 
ATOM   1314 N NH2 . ARG A 1 246 ? 132.302 135.932 130.305 1.00 80.40  ? 277 ARG A NH2 1 
ATOM   1315 N N   . GLN A 1 247 ? 130.775 140.162 133.700 1.00 68.16  ? 278 GLN A N   1 
ATOM   1316 C CA  . GLN A 1 247 ? 130.968 141.348 132.872 1.00 65.81  ? 278 GLN A CA  1 
ATOM   1317 C C   . GLN A 1 247 ? 130.904 142.625 133.696 1.00 65.52  ? 278 GLN A C   1 
ATOM   1318 O O   . GLN A 1 247 ? 131.389 143.673 133.256 1.00 68.93  ? 278 GLN A O   1 
ATOM   1319 C CB  . GLN A 1 247 ? 129.923 141.375 131.760 1.00 64.90  ? 278 GLN A CB  1 
ATOM   1320 C CG  . GLN A 1 247 ? 130.107 140.273 130.737 1.00 70.33  ? 278 GLN A CG  1 
ATOM   1321 C CD  . GLN A 1 247 ? 129.010 140.257 129.698 1.00 78.78  ? 278 GLN A CD  1 
ATOM   1322 O OE1 . GLN A 1 247 ? 128.204 141.182 129.616 1.00 82.55  ? 278 GLN A OE1 1 
ATOM   1323 N NE2 . GLN A 1 247 ? 128.964 139.195 128.905 1.00 80.45  ? 278 GLN A NE2 1 
ATOM   1324 N N   . GLU A 1 248 ? 130.306 142.562 134.883 1.00 64.23  ? 279 GLU A N   1 
ATOM   1325 C CA  . GLU A 1 248 ? 130.303 143.668 135.824 1.00 62.43  ? 279 GLU A CA  1 
ATOM   1326 C C   . GLU A 1 248 ? 131.387 143.540 136.881 1.00 65.20  ? 279 GLU A C   1 
ATOM   1327 O O   . GLU A 1 248 ? 131.332 144.263 137.882 1.00 66.51  ? 279 GLU A O   1 
ATOM   1328 C CB  . GLU A 1 248 ? 128.935 143.785 136.497 1.00 56.28  ? 279 GLU A CB  1 
ATOM   1329 C CG  . GLU A 1 248 ? 127.903 144.464 135.634 1.00 52.99  ? 279 GLU A CG  1 
ATOM   1330 C CD  . GLU A 1 248 ? 128.157 145.948 135.498 1.00 54.68  ? 279 GLU A CD  1 
ATOM   1331 O OE1 . GLU A 1 248 ? 128.638 146.563 136.473 1.00 55.06  ? 279 GLU A OE1 1 
ATOM   1332 O OE2 . GLU A 1 248 ? 127.885 146.499 134.412 1.00 55.50  ? 279 GLU A OE2 1 
ATOM   1333 N N   . HIS A 1 249 ? 132.349 142.636 136.675 1.00 65.01  ? 280 HIS A N   1 
ATOM   1334 C CA  . HIS A 1 249 ? 133.522 142.314 137.496 1.00 65.93  ? 280 HIS A CA  1 
ATOM   1335 C C   . HIS A 1 249 ? 133.153 141.889 138.911 1.00 65.99  ? 280 HIS A C   1 
ATOM   1336 O O   . HIS A 1 249 ? 133.873 142.236 139.851 1.00 70.20  ? 280 HIS A O   1 
ATOM   1337 C CB  . HIS A 1 249 ? 134.545 143.461 137.564 1.00 69.72  ? 280 HIS A CB  1 
ATOM   1338 C CG  . HIS A 1 249 ? 135.251 143.709 136.269 1.00 73.49  ? 280 HIS A CG  1 
ATOM   1339 N ND1 . HIS A 1 249 ? 135.460 142.716 135.338 1.00 75.69  ? 280 HIS A ND1 1 
ATOM   1340 C CD2 . HIS A 1 249 ? 135.780 144.838 135.743 1.00 74.82  ? 280 HIS A CD2 1 
ATOM   1341 C CE1 . HIS A 1 249 ? 136.097 143.220 134.297 1.00 78.23  ? 280 HIS A CE1 1 
ATOM   1342 N NE2 . HIS A 1 249 ? 136.302 144.506 134.517 1.00 79.99  ? 280 HIS A NE2 1 
ATOM   1343 N N   . MET A 1 250 ? 132.054 141.168 139.097 1.00 64.00  ? 281 MET A N   1 
ATOM   1344 C CA  . MET A 1 250 ? 131.685 140.620 140.392 1.00 62.46  ? 281 MET A CA  1 
ATOM   1345 C C   . MET A 1 250 ? 131.838 139.108 140.367 1.00 62.34  ? 281 MET A C   1 
ATOM   1346 O O   . MET A 1 250 ? 131.201 138.426 139.560 1.00 62.75  ? 281 MET A O   1 
ATOM   1347 C CB  . MET A 1 250 ? 130.247 140.985 140.757 1.00 62.41  ? 281 MET A CB  1 
ATOM   1348 C CG  . MET A 1 250 ? 130.014 142.455 141.054 1.00 61.69  ? 281 MET A CG  1 
ATOM   1349 S SD  . MET A 1 250 ? 128.317 143.029 140.796 1.00 63.19  ? 281 MET A SD  1 
ATOM   1350 C CE  . MET A 1 250 ? 127.335 141.553 141.067 1.00 52.05  ? 281 MET A CE  1 
ATOM   1351 N N   . CYS A 1 251 ? 132.680 138.591 141.248 1.00 61.63  ? 282 CYS A N   1 
ATOM   1352 C CA  . CYS A 1 251 ? 132.731 137.168 141.538 1.00 57.75  ? 282 CYS A CA  1 
ATOM   1353 C C   . CYS A 1 251 ? 132.176 136.925 142.936 1.00 55.85  ? 282 CYS A C   1 
ATOM   1354 O O   . CYS A 1 251 ? 132.718 137.416 143.931 1.00 56.95  ? 282 CYS A O   1 
ATOM   1355 C CB  . CYS A 1 251 ? 134.149 136.614 141.324 1.00 56.62  ? 282 CYS A CB  1 
ATOM   1356 S SG  . CYS A 1 251 ? 135.545 137.311 142.255 1.00 65.35  ? 282 CYS A SG  1 
ATOM   1357 N N   . LEU A 1 252 ? 131.050 136.217 142.988 1.00 53.08  ? 283 LEU A N   1 
ATOM   1358 C CA  . LEU A 1 252 ? 130.294 135.989 144.211 1.00 50.65  ? 283 LEU A CA  1 
ATOM   1359 C C   . LEU A 1 252 ? 130.713 134.646 144.788 1.00 51.53  ? 283 LEU A C   1 
ATOM   1360 O O   . LEU A 1 252 ? 130.445 133.597 144.194 1.00 53.05  ? 283 LEU A O   1 
ATOM   1361 C CB  . LEU A 1 252 ? 128.794 136.029 143.933 1.00 53.11  ? 283 LEU A CB  1 
ATOM   1362 C CG  . LEU A 1 252 ? 128.279 137.279 143.222 1.00 55.24  ? 283 LEU A CG  1 
ATOM   1363 C CD1 . LEU A 1 252 ? 126.874 137.056 142.699 1.00 54.20  ? 283 LEU A CD1 1 
ATOM   1364 C CD2 . LEU A 1 252 ? 128.314 138.476 144.153 1.00 54.27  ? 283 LEU A CD2 1 
ATOM   1365 N N   . MET A 1 253 ? 131.353 134.683 145.950 1.00 52.04  ? 284 MET A N   1 
ATOM   1366 C CA  . MET A 1 253 ? 131.915 133.503 146.582 1.00 51.41  ? 284 MET A CA  1 
ATOM   1367 C C   . MET A 1 253 ? 131.071 133.134 147.789 1.00 45.64  ? 284 MET A C   1 
ATOM   1368 O O   . MET A 1 253 ? 130.471 133.993 148.436 1.00 47.24  ? 284 MET A O   1 
ATOM   1369 C CB  . MET A 1 253 ? 133.362 133.743 147.035 1.00 53.92  ? 284 MET A CB  1 
ATOM   1370 C CG  . MET A 1 253 ? 134.277 134.361 145.998 1.00 54.21  ? 284 MET A CG  1 
ATOM   1371 S SD  . MET A 1 253 ? 134.747 133.171 144.746 1.00 59.13  ? 284 MET A SD  1 
ATOM   1372 C CE  . MET A 1 253 ? 135.620 131.987 145.757 1.00 62.84  ? 284 MET A CE  1 
ATOM   1373 N N   . HIS A 1 254 ? 131.032 131.842 148.094 1.00 41.51  ? 285 HIS A N   1 
ATOM   1374 C CA  . HIS A 1 254 ? 130.377 131.347 149.295 1.00 43.74  ? 285 HIS A CA  1 
ATOM   1375 C C   . HIS A 1 254 ? 131.433 131.001 150.334 1.00 46.16  ? 285 HIS A C   1 
ATOM   1376 O O   . HIS A 1 254 ? 132.416 130.325 150.022 1.00 50.62  ? 285 HIS A O   1 
ATOM   1377 C CB  . HIS A 1 254 ? 129.505 130.129 148.985 1.00 45.61  ? 285 HIS A CB  1 
ATOM   1378 C CG  . HIS A 1 254 ? 128.971 129.434 150.199 1.00 46.26  ? 285 HIS A CG  1 
ATOM   1379 N ND1 . HIS A 1 254 ? 127.834 129.852 150.855 1.00 46.81  ? 285 HIS A ND1 1 
ATOM   1380 C CD2 . HIS A 1 254 ? 129.392 128.323 150.849 1.00 47.81  ? 285 HIS A CD2 1 
ATOM   1381 C CE1 . HIS A 1 254 ? 127.595 129.047 151.875 1.00 49.46  ? 285 HIS A CE1 1 
ATOM   1382 N NE2 . HIS A 1 254 ? 128.526 128.110 151.893 1.00 50.24  ? 285 HIS A NE2 1 
ATOM   1383 N N   . PHE A 1 255 ? 131.230 131.466 151.562 1.00 44.98  ? 286 PHE A N   1 
ATOM   1384 C CA  . PHE A 1 255 ? 132.119 131.156 152.669 1.00 46.16  ? 286 PHE A CA  1 
ATOM   1385 C C   . PHE A 1 255 ? 131.352 130.393 153.733 1.00 52.17  ? 286 PHE A C   1 
ATOM   1386 O O   . PHE A 1 255 ? 130.175 130.066 153.571 1.00 54.51  ? 286 PHE A O   1 
ATOM   1387 C CB  . PHE A 1 255 ? 132.712 132.407 153.328 1.00 46.43  ? 286 PHE A CB  1 
ATOM   1388 C CG  . PHE A 1 255 ? 133.123 133.473 152.371 1.00 48.39  ? 286 PHE A CG  1 
ATOM   1389 C CD1 . PHE A 1 255 ? 134.078 133.218 151.388 1.00 50.41  ? 286 PHE A CD1 1 
ATOM   1390 C CD2 . PHE A 1 255 ? 132.572 134.749 152.476 1.00 48.85  ? 286 PHE A CD2 1 
ATOM   1391 C CE1 . PHE A 1 255 ? 134.471 134.225 150.504 1.00 51.37  ? 286 PHE A CE1 1 
ATOM   1392 C CE2 . PHE A 1 255 ? 132.948 135.759 151.602 1.00 48.69  ? 286 PHE A CE2 1 
ATOM   1393 C CZ  . PHE A 1 255 ? 133.898 135.496 150.614 1.00 53.24  ? 286 PHE A CZ  1 
ATOM   1394 N N   . LYS A 1 256 ? 132.049 130.107 154.832 1.00 57.24  ? 287 LYS A N   1 
ATOM   1395 C CA  . LYS A 1 256 ? 131.407 129.714 156.084 1.00 58.41  ? 287 LYS A CA  1 
ATOM   1396 C C   . LYS A 1 256 ? 131.354 130.952 156.975 1.00 56.75  ? 287 LYS A C   1 
ATOM   1397 O O   . LYS A 1 256 ? 131.988 131.036 158.029 1.00 56.45  ? 287 LYS A O   1 
ATOM   1398 C CB  . LYS A 1 256 ? 132.152 128.564 156.745 1.00 61.01  ? 287 LYS A CB  1 
ATOM   1399 C CG  . LYS A 1 256 ? 132.103 127.265 155.957 1.00 65.05  ? 287 LYS A CG  1 
ATOM   1400 C CD  . LYS A 1 256 ? 132.066 126.060 156.881 1.00 70.32  ? 287 LYS A CD  1 
ATOM   1401 C CE  . LYS A 1 256 ? 130.659 125.805 157.393 1.00 74.15  ? 287 LYS A CE  1 
ATOM   1402 N NZ  . LYS A 1 256 ? 129.677 125.718 156.279 1.00 75.02  ? 287 LYS A NZ  1 
ATOM   1403 N N   . SER A 1 257 ? 130.575 131.933 156.528 1.00 56.33  ? 288 SER A N   1 
ATOM   1404 C CA  . SER A 1 257 ? 130.470 133.232 157.176 1.00 56.51  ? 288 SER A CA  1 
ATOM   1405 C C   . SER A 1 257 ? 129.102 133.369 157.822 1.00 57.08  ? 288 SER A C   1 
ATOM   1406 O O   . SER A 1 257 ? 128.147 132.697 157.420 1.00 59.34  ? 288 SER A O   1 
ATOM   1407 C CB  . SER A 1 257 ? 130.689 134.365 156.174 1.00 53.99  ? 288 SER A CB  1 
ATOM   1408 O OG  . SER A 1 257 ? 130.147 135.578 156.657 1.00 55.11  ? 288 SER A OG  1 
ATOM   1409 N N   . ASP A 1 258 ? 129.015 134.233 158.835 1.00 57.87  ? 289 ASP A N   1 
ATOM   1410 C CA  . ASP A 1 258 ? 127.751 134.409 159.543 1.00 60.66  ? 289 ASP A CA  1 
ATOM   1411 C C   . ASP A 1 258 ? 126.784 135.274 158.741 1.00 59.63  ? 289 ASP A C   1 
ATOM   1412 O O   . ASP A 1 258 ? 125.563 135.142 158.877 1.00 60.04  ? 289 ASP A O   1 
ATOM   1413 C CB  . ASP A 1 258 ? 128.002 135.010 160.925 1.00 60.79  ? 289 ASP A CB  1 
ATOM   1414 C CG  . ASP A 1 258 ? 126.957 134.591 161.942 1.00 62.07  ? 289 ASP A CG  1 
ATOM   1415 O OD1 . ASP A 1 258 ? 126.040 133.824 161.578 1.00 59.13  ? 289 ASP A OD1 1 
ATOM   1416 O OD2 . ASP A 1 258 ? 127.057 135.024 163.109 1.00 63.95  ? 289 ASP A OD2 1 
ATOM   1417 N N   . ASP A 1 259 ? 127.310 136.167 157.907 1.00 54.59  ? 290 ASP A N   1 
ATOM   1418 C CA  . ASP A 1 259 ? 126.490 136.950 156.990 1.00 49.63  ? 290 ASP A CA  1 
ATOM   1419 C C   . ASP A 1 259 ? 126.199 136.099 155.761 1.00 47.26  ? 290 ASP A C   1 
ATOM   1420 O O   . ASP A 1 259 ? 127.088 135.410 155.255 1.00 51.45  ? 290 ASP A O   1 
ATOM   1421 C CB  . ASP A 1 259 ? 127.207 138.239 156.602 1.00 53.51  ? 290 ASP A CB  1 
ATOM   1422 C CG  . ASP A 1 259 ? 127.626 139.057 157.803 1.00 59.23  ? 290 ASP A CG  1 
ATOM   1423 O OD1 . ASP A 1 259 ? 127.105 138.802 158.910 1.00 65.41  ? 290 ASP A OD1 1 
ATOM   1424 O OD2 . ASP A 1 259 ? 128.483 139.952 157.642 1.00 53.14  ? 290 ASP A OD2 1 
ATOM   1425 N N   . ASN A 1 260 ? 124.963 136.141 155.277 1.00 41.85  ? 291 ASN A N   1 
ATOM   1426 C CA  . ASN A 1 260 ? 124.565 135.377 154.104 1.00 40.75  ? 291 ASN A CA  1 
ATOM   1427 C C   . ASN A 1 260 ? 123.827 136.288 153.140 1.00 37.46  ? 291 ASN A C   1 
ATOM   1428 O O   . ASN A 1 260 ? 123.273 137.310 153.551 1.00 41.48  ? 291 ASN A O   1 
ATOM   1429 C CB  . ASN A 1 260 ? 123.683 134.188 154.487 1.00 45.63  ? 291 ASN A CB  1 
ATOM   1430 C CG  . ASN A 1 260 ? 124.447 133.106 155.212 1.00 49.38  ? 291 ASN A CG  1 
ATOM   1431 O OD1 . ASN A 1 260 ? 125.570 132.770 154.845 1.00 49.35  ? 291 ASN A OD1 1 
ATOM   1432 N ND2 . ASN A 1 260 ? 123.841 132.552 156.254 1.00 50.07  ? 291 ASN A ND2 1 
ATOM   1433 N N   . VAL A 1 261 ? 123.863 135.941 151.856 1.00 34.36  ? 292 VAL A N   1 
ATOM   1434 C CA  . VAL A 1 261 ? 123.130 136.630 150.799 1.00 32.12  ? 292 VAL A CA  1 
ATOM   1435 C C   . VAL A 1 261 ? 122.466 135.556 149.945 1.00 36.53  ? 292 VAL A C   1 
ATOM   1436 O O   . VAL A 1 261 ? 123.133 134.616 149.502 1.00 42.32  ? 292 VAL A O   1 
ATOM   1437 C CB  . VAL A 1 261 ? 124.066 137.540 149.975 1.00 34.10  ? 292 VAL A CB  1 
ATOM   1438 C CG1 . VAL A 1 261 ? 123.517 137.856 148.596 1.00 35.77  ? 292 VAL A CG1 1 
ATOM   1439 C CG2 . VAL A 1 261 ? 124.307 138.855 150.690 1.00 35.51  ? 292 VAL A CG2 1 
ATOM   1440 N N   . TYR A 1 262 ? 121.152 135.663 149.748 1.00 34.03  ? 293 TYR A N   1 
ATOM   1441 C CA  . TYR A 1 262 ? 120.407 134.682 148.963 1.00 33.45  ? 293 TYR A CA  1 
ATOM   1442 C C   . TYR A 1 262 ? 119.777 135.365 147.759 1.00 35.02  ? 293 TYR A C   1 
ATOM   1443 O O   . TYR A 1 262 ? 118.728 135.998 147.885 1.00 40.11  ? 293 TYR A O   1 
ATOM   1444 C CB  . TYR A 1 262 ? 119.334 134.002 149.805 1.00 37.19  ? 293 TYR A CB  1 
ATOM   1445 C CG  . TYR A 1 262 ? 119.849 133.284 151.025 1.00 44.11  ? 293 TYR A CG  1 
ATOM   1446 C CD1 . TYR A 1 262 ? 120.346 131.979 150.928 1.00 47.57  ? 293 TYR A CD1 1 
ATOM   1447 C CD2 . TYR A 1 262 ? 119.813 133.898 152.279 1.00 46.90  ? 293 TYR A CD2 1 
ATOM   1448 C CE1 . TYR A 1 262 ? 120.813 131.306 152.054 1.00 50.48  ? 293 TYR A CE1 1 
ATOM   1449 C CE2 . TYR A 1 262 ? 120.277 133.237 153.412 1.00 50.07  ? 293 TYR A CE2 1 
ATOM   1450 C CZ  . TYR A 1 262 ? 120.771 131.945 153.287 1.00 53.72  ? 293 TYR A CZ  1 
ATOM   1451 O OH  . TYR A 1 262 ? 121.228 131.289 154.405 1.00 56.75  ? 293 TYR A OH  1 
ATOM   1452 N N   . ILE A 1 263 ? 120.382 135.211 146.589 1.00 32.36  ? 294 ILE A N   1 
ATOM   1453 C CA  . ILE A 1 263 ? 119.847 135.775 145.356 1.00 32.38  ? 294 ILE A CA  1 
ATOM   1454 C C   . ILE A 1 263 ? 118.991 134.706 144.697 1.00 36.97  ? 294 ILE A C   1 
ATOM   1455 O O   . ILE A 1 263 ? 119.515 133.758 144.107 1.00 43.41  ? 294 ILE A O   1 
ATOM   1456 C CB  . ILE A 1 263 ? 120.960 136.250 144.419 1.00 37.01  ? 294 ILE A CB  1 
ATOM   1457 C CG1 . ILE A 1 263 ? 121.989 137.061 145.207 1.00 40.48  ? 294 ILE A CG1 1 
ATOM   1458 C CG2 . ILE A 1 263 ? 120.366 137.056 143.283 1.00 40.16  ? 294 ILE A CG2 1 
ATOM   1459 C CD1 . ILE A 1 263 ? 123.119 137.633 144.377 1.00 45.75  ? 294 ILE A CD1 1 
ATOM   1460 N N   . MET A 1 264 ? 117.673 134.858 144.775 1.00 38.41  ? 295 MET A N   1 
ATOM   1461 C CA  . MET A 1 264 ? 116.737 133.848 144.302 1.00 39.85  ? 295 MET A CA  1 
ATOM   1462 C C   . MET A 1 264 ? 116.130 134.277 142.977 1.00 41.64  ? 295 MET A C   1 
ATOM   1463 O O   . MET A 1 264 ? 115.746 135.439 142.813 1.00 45.02  ? 295 MET A O   1 
ATOM   1464 C CB  . MET A 1 264 ? 115.641 133.599 145.331 1.00 40.78  ? 295 MET A CB  1 
ATOM   1465 C CG  . MET A 1 264 ? 116.166 132.954 146.586 1.00 44.79  ? 295 MET A CG  1 
ATOM   1466 S SD  . MET A 1 264 ? 114.907 132.651 147.826 1.00 73.03  ? 295 MET A SD  1 
ATOM   1467 C CE  . MET A 1 264 ? 115.923 131.996 149.140 1.00 65.81  ? 295 MET A CE  1 
ATOM   1468 N N   . PHE A 1 265 ? 116.041 133.337 142.041 1.00 42.68  ? 296 PHE A N   1 
ATOM   1469 C CA  . PHE A 1 265 ? 115.548 133.583 140.692 1.00 45.12  ? 296 PHE A CA  1 
ATOM   1470 C C   . PHE A 1 265 ? 114.279 132.775 140.470 1.00 50.65  ? 296 PHE A C   1 
ATOM   1471 O O   . PHE A 1 265 ? 114.345 131.559 140.277 1.00 57.54  ? 296 PHE A O   1 
ATOM   1472 C CB  . PHE A 1 265 ? 116.601 133.215 139.646 1.00 45.66  ? 296 PHE A CB  1 
ATOM   1473 C CG  . PHE A 1 265 ? 117.764 134.158 139.605 1.00 46.38  ? 296 PHE A CG  1 
ATOM   1474 C CD1 . PHE A 1 265 ? 118.885 133.942 140.404 1.00 47.26  ? 296 PHE A CD1 1 
ATOM   1475 C CD2 . PHE A 1 265 ? 117.735 135.264 138.760 1.00 48.78  ? 296 PHE A CD2 1 
ATOM   1476 C CE1 . PHE A 1 265 ? 119.959 134.826 140.366 1.00 48.44  ? 296 PHE A CE1 1 
ATOM   1477 C CE2 . PHE A 1 265 ? 118.800 136.159 138.723 1.00 48.73  ? 296 PHE A CE2 1 
ATOM   1478 C CZ  . PHE A 1 265 ? 119.909 135.933 139.524 1.00 50.15  ? 296 PHE A CZ  1 
ATOM   1479 N N   . GLY A 1 266 ? 113.133 133.447 140.487 1.00 50.15  ? 297 GLY A N   1 
ATOM   1480 C CA  . GLY A 1 266 ? 111.875 132.764 140.268 1.00 52.22  ? 297 GLY A CA  1 
ATOM   1481 C C   . GLY A 1 266 ? 110.747 133.269 141.140 1.00 56.79  ? 297 GLY A C   1 
ATOM   1482 O O   . GLY A 1 266 ? 110.985 133.876 142.188 1.00 57.96  ? 297 GLY A O   1 
ATOM   1483 N N   . ASN A 1 267 ? 109.509 133.030 140.703 1.00 62.39  ? 298 ASN A N   1 
ATOM   1484 C CA  . ASN A 1 267 ? 108.344 133.481 141.458 1.00 64.08  ? 298 ASN A CA  1 
ATOM   1485 C C   . ASN A 1 267 ? 108.061 132.575 142.650 1.00 66.58  ? 298 ASN A C   1 
ATOM   1486 O O   . ASN A 1 267 ? 107.673 133.048 143.724 1.00 67.46  ? 298 ASN A O   1 
ATOM   1487 C CB  . ASN A 1 267 ? 107.127 133.543 140.539 1.00 66.44  ? 298 ASN A CB  1 
ATOM   1488 C CG  . ASN A 1 267 ? 107.011 134.859 139.818 1.00 65.87  ? 298 ASN A CG  1 
ATOM   1489 O OD1 . ASN A 1 267 ? 107.034 135.920 140.436 1.00 66.37  ? 298 ASN A OD1 1 
ATOM   1490 N ND2 . ASN A 1 267 ? 106.893 134.802 138.498 1.00 64.49  ? 298 ASN A ND2 1 
ATOM   1491 N N   . LYS A 1 268 ? 108.244 131.267 142.478 1.00 65.14  ? 299 LYS A N   1 
ATOM   1492 C CA  . LYS A 1 268 ? 107.779 130.319 143.486 1.00 66.84  ? 299 LYS A CA  1 
ATOM   1493 C C   . LYS A 1 268 ? 108.839 130.052 144.547 1.00 70.45  ? 299 LYS A C   1 
ATOM   1494 O O   . LYS A 1 268 ? 108.565 129.374 145.543 1.00 72.66  ? 299 LYS A O   1 
ATOM   1495 C CB  . LYS A 1 268 ? 107.356 129.012 142.815 1.00 70.27  ? 299 LYS A CB  1 
ATOM   1496 C CG  . LYS A 1 268 ? 105.864 128.895 142.522 1.00 75.77  ? 299 LYS A CG  1 
ATOM   1497 C CD  . LYS A 1 268 ? 105.462 129.645 141.257 1.00 78.98  ? 299 LYS A CD  1 
ATOM   1498 C CE  . LYS A 1 268 ? 106.063 129.008 140.014 1.00 79.51  ? 299 LYS A CE  1 
ATOM   1499 N NZ  . LYS A 1 268 ? 105.640 129.707 138.768 1.00 80.83  ? 299 LYS A NZ  1 
ATOM   1500 N N   . LEU A 1 269 ? 110.051 130.576 144.357 1.00 67.58  ? 300 LEU A N   1 
ATOM   1501 C CA  . LEU A 1 269 ? 111.183 130.184 145.190 1.00 61.33  ? 300 LEU A CA  1 
ATOM   1502 C C   . LEU A 1 269 ? 111.199 130.919 146.521 1.00 67.01  ? 300 LEU A C   1 
ATOM   1503 O O   . LEU A 1 269 ? 111.379 130.310 147.580 1.00 71.07  ? 300 LEU A O   1 
ATOM   1504 C CB  . LEU A 1 269 ? 112.494 130.422 144.437 1.00 55.62  ? 300 LEU A CB  1 
ATOM   1505 C CG  . LEU A 1 269 ? 113.158 129.243 143.727 1.00 56.32  ? 300 LEU A CG  1 
ATOM   1506 C CD1 . LEU A 1 269 ? 112.297 128.636 142.639 1.00 61.25  ? 300 LEU A CD1 1 
ATOM   1507 C CD2 . LEU A 1 269 ? 114.473 129.698 143.149 1.00 53.28  ? 300 LEU A CD2 1 
ATOM   1508 N N   . ALA A 1 270 ? 111.011 132.237 146.481 1.00 67.11  ? 301 ALA A N   1 
ATOM   1509 C CA  . ALA A 1 270 ? 111.019 133.052 147.694 1.00 68.62  ? 301 ALA A CA  1 
ATOM   1510 C C   . ALA A 1 270 ? 109.593 133.150 148.236 1.00 73.26  ? 301 ALA A C   1 
ATOM   1511 O O   . ALA A 1 270 ? 108.890 134.148 148.077 1.00 75.03  ? 301 ALA A O   1 
ATOM   1512 C CB  . ALA A 1 270 ? 111.612 134.423 147.414 1.00 60.28  ? 301 ALA A CB  1 
ATOM   1513 N N   . SER A 1 271 ? 109.164 132.070 148.878 1.00 74.84  ? 302 SER A N   1 
ATOM   1514 C CA  . SER A 1 271 ? 107.839 131.989 149.477 1.00 76.26  ? 302 SER A CA  1 
ATOM   1515 C C   . SER A 1 271 ? 107.989 131.558 150.927 1.00 81.86  ? 302 SER A C   1 
ATOM   1516 O O   . SER A 1 271 ? 108.123 130.356 151.197 1.00 82.73  ? 302 SER A O   1 
ATOM   1517 C CB  . SER A 1 271 ? 106.950 131.012 148.709 1.00 76.49  ? 302 SER A CB  1 
ATOM   1518 O OG  . SER A 1 271 ? 105.642 130.982 149.252 1.00 82.43  ? 302 SER A OG  1 
ATOM   1519 N N   . HIS A 1 272 ? 107.954 132.553 151.835 1.00 81.50  ? 303 HIS A N   1 
ATOM   1520 C CA  . HIS A 1 272 ? 108.126 132.432 153.299 1.00 84.15  ? 303 HIS A CA  1 
ATOM   1521 C C   . HIS A 1 272 ? 109.446 131.757 153.676 1.00 86.23  ? 303 HIS A C   1 
ATOM   1522 O O   . HIS A 1 272 ? 109.473 130.728 154.355 1.00 88.67  ? 303 HIS A O   1 
ATOM   1523 C CB  . HIS A 1 272 ? 106.933 131.727 153.961 1.00 83.99  ? 303 HIS A CB  1 
ATOM   1524 N N   . PHE A 1 273 ? 110.552 132.342 153.222 1.00 83.65  ? 304 PHE A N   1 
ATOM   1525 C CA  . PHE A 1 273 ? 111.862 131.765 153.492 1.00 83.81  ? 304 PHE A CA  1 
ATOM   1526 C C   . PHE A 1 273 ? 112.325 132.151 154.893 1.00 85.81  ? 304 PHE A C   1 
ATOM   1527 O O   . PHE A 1 273 ? 111.980 133.223 155.399 1.00 85.81  ? 304 PHE A O   1 
ATOM   1528 C CB  . PHE A 1 273 ? 112.866 132.227 152.442 1.00 82.96  ? 304 PHE A CB  1 
ATOM   1529 C CG  . PHE A 1 273 ? 113.993 131.269 152.233 1.00 85.56  ? 304 PHE A CG  1 
ATOM   1530 C CD1 . PHE A 1 273 ? 113.781 130.085 151.523 1.00 84.11  ? 304 PHE A CD1 1 
ATOM   1531 C CD2 . PHE A 1 273 ? 115.259 131.538 152.753 1.00 83.72  ? 304 PHE A CD2 1 
ATOM   1532 C CE1 . PHE A 1 273 ? 114.825 129.178 151.324 1.00 84.41  ? 304 PHE A CE1 1 
ATOM   1533 C CE2 . PHE A 1 273 ? 116.312 130.641 152.561 1.00 78.64  ? 304 PHE A CE2 1 
ATOM   1534 C CZ  . PHE A 1 273 ? 116.091 129.460 151.847 1.00 83.73  ? 304 PHE A CZ  1 
ATOM   1535 N N   . LYS A 1 274 ? 113.111 131.277 155.520 1.00 85.36  ? 305 LYS A N   1 
ATOM   1536 C CA  . LYS A 1 274 ? 113.339 131.361 156.957 1.00 84.76  ? 305 LYS A CA  1 
ATOM   1537 C C   . LYS A 1 274 ? 114.778 131.675 157.355 1.00 82.42  ? 305 LYS A C   1 
ATOM   1538 O O   . LYS A 1 274 ? 115.030 131.888 158.546 1.00 80.25  ? 305 LYS A O   1 
ATOM   1539 C CB  . LYS A 1 274 ? 112.910 130.051 157.625 1.00 85.17  ? 305 LYS A CB  1 
ATOM   1540 N N   . GLU A 1 275 ? 115.724 131.704 156.417 1.00 80.20  ? 306 GLU A N   1 
ATOM   1541 C CA  . GLU A 1 275 ? 117.103 132.007 156.779 1.00 74.44  ? 306 GLU A CA  1 
ATOM   1542 C C   . GLU A 1 275 ? 117.279 133.514 156.961 1.00 68.96  ? 306 GLU A C   1 
ATOM   1543 O O   . GLU A 1 275 ? 116.477 134.326 156.495 1.00 72.02  ? 306 GLU A O   1 
ATOM   1544 C CB  . GLU A 1 275 ? 118.069 131.443 155.739 1.00 72.00  ? 306 GLU A CB  1 
ATOM   1545 C CG  . GLU A 1 275 ? 118.106 129.908 155.666 1.00 74.00  ? 306 GLU A CG  1 
ATOM   1546 C CD  . GLU A 1 275 ? 118.678 129.241 156.914 1.00 76.88  ? 306 GLU A CD  1 
ATOM   1547 O OE1 . GLU A 1 275 ? 119.565 129.828 157.571 1.00 78.27  ? 306 GLU A OE1 1 
ATOM   1548 O OE2 . GLU A 1 275 ? 118.232 128.121 157.242 1.00 74.13  ? 306 GLU A OE2 1 
ATOM   1549 N N   . ASN A 1 276 ? 118.355 133.891 157.653 1.00 66.18  ? 307 ASN A N   1 
ATOM   1550 C CA  . ASN A 1 276 ? 118.479 135.228 158.224 1.00 68.27  ? 307 ASN A CA  1 
ATOM   1551 C C   . ASN A 1 276 ? 119.250 136.203 157.340 1.00 63.00  ? 307 ASN A C   1 
ATOM   1552 O O   . ASN A 1 276 ? 119.424 137.364 157.725 1.00 57.80  ? 307 ASN A O   1 
ATOM   1553 C CB  . ASN A 1 276 ? 119.141 135.142 159.604 1.00 72.44  ? 307 ASN A CB  1 
ATOM   1554 C CG  . ASN A 1 276 ? 118.610 136.177 160.576 1.00 74.07  ? 307 ASN A CG  1 
ATOM   1555 O OD1 . ASN A 1 276 ? 117.693 136.932 160.257 1.00 74.11  ? 307 ASN A OD1 1 
ATOM   1556 N ND2 . ASN A 1 276 ? 119.194 136.224 161.768 1.00 71.95  ? 307 ASN A ND2 1 
ATOM   1557 N N   . GLY A 1 277 ? 119.702 135.781 156.160 1.00 60.07  ? 308 GLY A N   1 
ATOM   1558 C CA  . GLY A 1 277 ? 120.454 136.638 155.275 1.00 49.02  ? 308 GLY A CA  1 
ATOM   1559 C C   . GLY A 1 277 ? 119.549 137.553 154.468 1.00 43.41  ? 308 GLY A C   1 
ATOM   1560 O O   . GLY A 1 277 ? 118.324 137.414 154.467 1.00 46.95  ? 308 GLY A O   1 
ATOM   1561 N N   . THR A 1 278 ? 120.184 138.502 153.784 1.00 37.66  ? 309 THR A N   1 
ATOM   1562 C CA  . THR A 1 278 ? 119.449 139.405 152.910 1.00 35.46  ? 309 THR A CA  1 
ATOM   1563 C C   . THR A 1 278 ? 119.073 138.688 151.623 1.00 36.44  ? 309 THR A C   1 
ATOM   1564 O O   . THR A 1 278 ? 119.876 137.952 151.050 1.00 40.33  ? 309 THR A O   1 
ATOM   1565 C CB  . THR A 1 278 ? 120.282 140.641 152.594 1.00 35.83  ? 309 THR A CB  1 
ATOM   1566 O OG1 . THR A 1 278 ? 121.350 140.281 151.713 1.00 38.02  ? 309 THR A OG1 1 
ATOM   1567 C CG2 . THR A 1 278 ? 120.862 141.223 153.868 1.00 35.54  ? 309 THR A CG2 1 
ATOM   1568 N N   . LEU A 1 279 ? 117.844 138.912 151.157 1.00 34.04  ? 310 LEU A N   1 
ATOM   1569 C CA  . LEU A 1 279 ? 117.258 138.103 150.089 1.00 31.25  ? 310 LEU A CA  1 
ATOM   1570 C C   . LEU A 1 279 ? 117.008 139.011 148.890 1.00 32.53  ? 310 LEU A C   1 
ATOM   1571 O O   . LEU A 1 279 ? 116.401 140.073 149.015 1.00 37.54  ? 310 LEU A O   1 
ATOM   1572 C CB  . LEU A 1 279 ? 115.988 137.398 150.596 1.00 35.23  ? 310 LEU A CB  1 
ATOM   1573 C CG  . LEU A 1 279 ? 115.191 136.334 149.828 1.00 44.25  ? 310 LEU A CG  1 
ATOM   1574 C CD1 . LEU A 1 279 ? 114.498 135.459 150.853 1.00 56.46  ? 310 LEU A CD1 1 
ATOM   1575 C CD2 . LEU A 1 279 ? 114.129 136.896 148.896 1.00 40.99  ? 310 LEU A CD2 1 
ATOM   1576 N N   . PHE A 1 280 ? 117.491 138.583 147.722 1.00 32.38  ? 311 PHE A N   1 
ATOM   1577 C CA  . PHE A 1 280 ? 117.277 139.291 146.460 1.00 30.85  ? 311 PHE A CA  1 
ATOM   1578 C C   . PHE A 1 280 ? 116.412 138.425 145.553 1.00 32.45  ? 311 PHE A C   1 
ATOM   1579 O O   . PHE A 1 280 ? 116.894 137.596 144.781 1.00 36.19  ? 311 PHE A O   1 
ATOM   1580 C CB  . PHE A 1 280 ? 118.601 139.625 145.790 1.00 31.13  ? 311 PHE A CB  1 
ATOM   1581 C CG  . PHE A 1 280 ? 119.488 140.501 146.604 1.00 33.42  ? 311 PHE A CG  1 
ATOM   1582 C CD1 . PHE A 1 280 ? 119.288 141.875 146.604 1.00 33.84  ? 311 PHE A CD1 1 
ATOM   1583 C CD2 . PHE A 1 280 ? 120.527 139.961 147.361 1.00 36.00  ? 311 PHE A CD2 1 
ATOM   1584 C CE1 . PHE A 1 280 ? 120.096 142.709 147.356 1.00 33.93  ? 311 PHE A CE1 1 
ATOM   1585 C CE2 . PHE A 1 280 ? 121.350 140.791 148.121 1.00 38.28  ? 311 PHE A CE2 1 
ATOM   1586 C CZ  . PHE A 1 280 ? 121.128 142.166 148.111 1.00 37.25  ? 311 PHE A CZ  1 
ATOM   1587 N N   . SER A 1 281 ? 115.104 138.634 145.646 1.00 31.57  ? 312 SER A N   1 
ATOM   1588 C CA  . SER A 1 281 ? 114.175 137.866 144.833 1.00 32.84  ? 312 SER A CA  1 
ATOM   1589 C C   . SER A 1 281 ? 114.103 138.440 143.428 1.00 34.48  ? 312 SER A C   1 
ATOM   1590 O O   . SER A 1 281 ? 113.813 139.619 143.239 1.00 37.92  ? 312 SER A O   1 
ATOM   1591 C CB  . SER A 1 281 ? 112.790 137.875 145.466 1.00 38.11  ? 312 SER A CB  1 
ATOM   1592 O OG  . SER A 1 281 ? 111.858 137.211 144.636 1.00 44.24  ? 312 SER A OG  1 
ATOM   1593 N N   . VAL A 1 282 ? 114.384 137.606 142.434 1.00 36.30  ? 313 VAL A N   1 
ATOM   1594 C CA  . VAL A 1 282 ? 114.261 138.034 141.044 1.00 37.71  ? 313 VAL A CA  1 
ATOM   1595 C C   . VAL A 1 282 ? 113.115 137.260 140.402 1.00 41.87  ? 313 VAL A C   1 
ATOM   1596 O O   . VAL A 1 282 ? 113.279 136.068 140.106 1.00 48.57  ? 313 VAL A O   1 
ATOM   1597 C CB  . VAL A 1 282 ? 115.570 137.826 140.270 1.00 36.77  ? 313 VAL A CB  1 
ATOM   1598 C CG1 . VAL A 1 282 ? 115.437 138.352 138.859 1.00 40.40  ? 313 VAL A CG1 1 
ATOM   1599 C CG2 . VAL A 1 282 ? 116.735 138.498 140.974 1.00 36.53  ? 313 VAL A CG2 1 
ATOM   1600 N N   . PRO A 1 283 ? 111.938 137.863 140.214 1.00 40.01  ? 314 PRO A N   1 
ATOM   1601 C CA  . PRO A 1 283 ? 110.854 137.159 139.522 1.00 44.76  ? 314 PRO A CA  1 
ATOM   1602 C C   . PRO A 1 283 ? 111.110 137.057 138.027 1.00 50.57  ? 314 PRO A C   1 
ATOM   1603 O O   . PRO A 1 283 ? 111.575 138.004 137.391 1.00 49.68  ? 314 PRO A O   1 
ATOM   1604 C CB  . PRO A 1 283 ? 109.625 138.021 139.826 1.00 45.98  ? 314 PRO A CB  1 
ATOM   1605 C CG  . PRO A 1 283 ? 110.168 139.337 140.178 1.00 41.80  ? 314 PRO A CG  1 
ATOM   1606 C CD  . PRO A 1 283 ? 111.430 139.058 140.903 1.00 40.97  ? 314 PRO A CD  1 
ATOM   1607 N N   . THR A 1 284 ? 110.804 135.887 137.472 1.00 55.18  ? 315 THR A N   1 
ATOM   1608 C CA  . THR A 1 284 ? 111.034 135.595 136.066 1.00 54.89  ? 315 THR A CA  1 
ATOM   1609 C C   . THR A 1 284 ? 109.778 135.711 135.215 1.00 54.86  ? 315 THR A C   1 
ATOM   1610 O O   . THR A 1 284 ? 109.865 135.576 133.993 1.00 60.54  ? 315 THR A O   1 
ATOM   1611 C CB  . THR A 1 284 ? 111.629 134.195 135.914 1.00 61.12  ? 315 THR A CB  1 
ATOM   1612 O OG1 . THR A 1 284 ? 111.934 133.951 134.537 1.00 66.21  ? 315 THR A OG1 1 
ATOM   1613 C CG2 . THR A 1 284 ? 110.651 133.145 136.411 1.00 59.96  ? 315 THR A CG2 1 
ATOM   1614 N N   . ASP A 1 285 ? 108.621 135.963 135.819 1.00 54.01  ? 316 ASP A N   1 
ATOM   1615 C CA  . ASP A 1 285 ? 107.400 136.187 135.061 1.00 58.22  ? 316 ASP A CA  1 
ATOM   1616 C C   . ASP A 1 285 ? 106.635 137.342 135.683 1.00 61.98  ? 316 ASP A C   1 
ATOM   1617 O O   . ASP A 1 285 ? 107.172 138.113 136.481 1.00 65.65  ? 316 ASP A O   1 
ATOM   1618 C CB  . ASP A 1 285 ? 106.514 134.939 135.001 1.00 63.38  ? 316 ASP A CB  1 
ATOM   1619 C CG  . ASP A 1 285 ? 107.047 133.891 134.046 1.00 65.08  ? 316 ASP A CG  1 
ATOM   1620 O OD1 . ASP A 1 285 ? 107.426 134.267 132.919 1.00 64.88  ? 316 ASP A OD1 1 
ATOM   1621 O OD2 . ASP A 1 285 ? 107.057 132.699 134.413 1.00 65.00  ? 316 ASP A OD2 1 
ATOM   1622 N N   . ARG A 1 286 ? 105.373 137.466 135.279 1.00 61.26  ? 317 ARG A N   1 
ATOM   1623 C CA  . ARG A 1 286 ? 104.499 138.485 135.837 1.00 64.44  ? 317 ARG A CA  1 
ATOM   1624 C C   . ARG A 1 286 ? 104.088 138.115 137.254 1.00 68.53  ? 317 ARG A C   1 
ATOM   1625 O O   . ARG A 1 286 ? 103.831 136.949 137.561 1.00 69.41  ? 317 ARG A O   1 
ATOM   1626 C CB  . ARG A 1 286 ? 103.257 138.656 134.968 1.00 64.65  ? 317 ARG A CB  1 
ATOM   1627 C CG  . ARG A 1 286 ? 103.532 139.204 133.593 1.00 60.57  ? 317 ARG A CG  1 
ATOM   1628 C CD  . ARG A 1 286 ? 102.246 139.382 132.819 1.00 58.55  ? 317 ARG A CD  1 
ATOM   1629 N NE  . ARG A 1 286 ? 101.740 140.740 132.964 1.00 57.88  ? 317 ARG A NE  1 
ATOM   1630 C CZ  . ARG A 1 286 ? 101.589 141.592 131.961 1.00 57.41  ? 317 ARG A CZ  1 
ATOM   1631 N NH1 . ARG A 1 286 ? 101.881 141.254 130.717 1.00 53.52  ? 317 ARG A NH1 1 
ATOM   1632 N NH2 . ARG A 1 286 ? 101.135 142.815 132.214 1.00 57.48  ? 317 ARG A NH2 1 
ATOM   1633 N N   . THR A 1 287 ? 104.042 139.118 138.121 1.00 72.95  ? 318 THR A N   1 
ATOM   1634 C CA  . THR A 1 287 ? 103.723 138.874 139.515 1.00 74.23  ? 318 THR A CA  1 
ATOM   1635 C C   . THR A 1 287 ? 102.225 139.029 139.762 1.00 76.65  ? 318 THR A C   1 
ATOM   1636 O O   . THR A 1 287 ? 101.507 139.701 139.015 1.00 79.06  ? 318 THR A O   1 
ATOM   1637 C CB  . THR A 1 287 ? 104.508 139.831 140.402 1.00 72.80  ? 318 THR A CB  1 
ATOM   1638 O OG1 . THR A 1 287 ? 104.106 141.176 140.124 1.00 71.12  ? 318 THR A OG1 1 
ATOM   1639 C CG2 . THR A 1 287 ? 105.979 139.696 140.082 1.00 68.17  ? 318 THR A CG2 1 
ATOM   1640 N N   . ASP A 1 288 ? 101.760 138.403 140.840 1.00 75.96  ? 319 ASP A N   1 
ATOM   1641 C CA  . ASP A 1 288 ? 100.367 138.481 141.247 1.00 80.23  ? 319 ASP A CA  1 
ATOM   1642 C C   . ASP A 1 288 ? 100.340 138.746 142.741 1.00 77.63  ? 319 ASP A C   1 
ATOM   1643 O O   . ASP A 1 288 ? 101.386 138.859 143.378 1.00 76.39  ? 319 ASP A O   1 
ATOM   1644 C CB  . ASP A 1 288 ? 99.606  137.197 140.897 1.00 82.41  ? 319 ASP A CB  1 
ATOM   1645 C CG  . ASP A 1 288 ? 100.273 135.954 141.453 1.00 79.47  ? 319 ASP A CG  1 
ATOM   1646 O OD1 . ASP A 1 288 ? 101.520 135.894 141.452 1.00 77.97  ? 319 ASP A OD1 1 
ATOM   1647 O OD2 . ASP A 1 288 ? 99.550  135.033 141.886 1.00 78.78  ? 319 ASP A OD2 1 
ATOM   1648 N N   . ASP A 1 289 ? 99.133  138.751 143.319 1.00 80.52  ? 320 ASP A N   1 
ATOM   1649 C CA  . ASP A 1 289 ? 98.951  139.196 144.702 1.00 80.84  ? 320 ASP A CA  1 
ATOM   1650 C C   . ASP A 1 289 ? 99.383  138.135 145.710 1.00 78.41  ? 320 ASP A C   1 
ATOM   1651 O O   . ASP A 1 289 ? 99.540  138.430 146.901 1.00 76.52  ? 320 ASP A O   1 
ATOM   1652 C CB  . ASP A 1 289 ? 97.490  139.582 144.939 1.00 85.23  ? 320 ASP A CB  1 
ATOM   1653 C CG  . ASP A 1 289 ? 97.045  140.741 144.070 1.00 88.88  ? 320 ASP A CG  1 
ATOM   1654 O OD1 . ASP A 1 289 ? 97.911  141.362 143.420 1.00 89.56  ? 320 ASP A OD1 1 
ATOM   1655 O OD2 . ASP A 1 289 ? 95.831  141.032 144.037 1.00 93.70  ? 320 ASP A OD2 1 
ATOM   1656 N N   . GLU A 1 290 ? 99.559  136.892 145.257 1.00 78.09  ? 321 GLU A N   1 
ATOM   1657 C CA  . GLU A 1 290 ? 100.163 135.871 146.101 1.00 78.67  ? 321 GLU A CA  1 
ATOM   1658 C C   . GLU A 1 290 ? 101.651 136.128 146.296 1.00 76.97  ? 321 GLU A C   1 
ATOM   1659 O O   . GLU A 1 290 ? 102.201 135.821 147.359 1.00 75.96  ? 321 GLU A O   1 
ATOM   1660 C CB  . GLU A 1 290 ? 99.938  134.487 145.489 1.00 83.30  ? 321 GLU A CB  1 
ATOM   1661 C CG  . GLU A 1 290 ? 100.150 133.324 146.453 1.00 85.20  ? 321 GLU A CG  1 
ATOM   1662 C CD  . GLU A 1 290 ? 100.162 131.981 145.755 1.00 84.96  ? 321 GLU A CD  1 
ATOM   1663 O OE1 . GLU A 1 290 ? 99.986  131.951 144.521 1.00 84.36  ? 321 GLU A OE1 1 
ATOM   1664 O OE2 . GLU A 1 290 ? 100.365 130.957 146.439 1.00 84.57  ? 321 GLU A OE2 1 
ATOM   1665 N N   . PHE A 1 291 ? 102.318 136.699 145.286 1.00 75.17  ? 322 PHE A N   1 
ATOM   1666 C CA  . PHE A 1 291 ? 103.774 136.824 145.329 1.00 69.33  ? 322 PHE A CA  1 
ATOM   1667 C C   . PHE A 1 291 ? 104.219 137.973 146.230 1.00 70.09  ? 322 PHE A C   1 
ATOM   1668 O O   . PHE A 1 291 ? 105.214 137.849 146.946 1.00 70.53  ? 322 PHE A O   1 
ATOM   1669 C CB  . PHE A 1 291 ? 104.341 136.995 143.921 1.00 68.44  ? 322 PHE A CB  1 
ATOM   1670 C CG  . PHE A 1 291 ? 105.826 137.217 143.893 1.00 65.55  ? 322 PHE A CG  1 
ATOM   1671 C CD1 . PHE A 1 291 ? 106.692 136.182 144.253 1.00 65.51  ? 322 PHE A CD1 1 
ATOM   1672 C CD2 . PHE A 1 291 ? 106.358 138.452 143.518 1.00 67.28  ? 322 PHE A CD2 1 
ATOM   1673 C CE1 . PHE A 1 291 ? 108.073 136.369 144.233 1.00 63.52  ? 322 PHE A CE1 1 
ATOM   1674 C CE2 . PHE A 1 291 ? 107.736 138.655 143.495 1.00 63.54  ? 322 PHE A CE2 1 
ATOM   1675 C CZ  . PHE A 1 291 ? 108.592 137.610 143.853 1.00 60.62  ? 322 PHE A CZ  1 
ATOM   1676 N N   . LEU A 1 292 ? 103.475 139.088 146.248 1.00 74.50  ? 323 LEU A N   1 
ATOM   1677 C CA  . LEU A 1 292 ? 103.878 140.218 147.094 1.00 73.01  ? 323 LEU A CA  1 
ATOM   1678 C C   . LEU A 1 292 ? 103.495 140.015 148.560 1.00 71.33  ? 323 LEU A C   1 
ATOM   1679 O O   . LEU A 1 292 ? 103.941 140.774 149.427 1.00 67.05  ? 323 LEU A O   1 
ATOM   1680 C CB  . LEU A 1 292 ? 103.300 141.545 146.581 1.00 77.61  ? 323 LEU A CB  1 
ATOM   1681 C CG  . LEU A 1 292 ? 103.709 142.185 145.241 1.00 82.63  ? 323 LEU A CG  1 
ATOM   1682 C CD1 . LEU A 1 292 ? 102.885 141.748 144.079 1.00 76.90  ? 323 LEU A CD1 1 
ATOM   1683 C CD2 . LEU A 1 292 ? 103.629 143.699 145.334 1.00 88.20  ? 323 LEU A CD2 1 
ATOM   1684 N N   . ALA A 1 293 ? 102.670 139.012 148.863 1.00 73.62  ? 324 ALA A N   1 
ATOM   1685 C CA  . ALA A 1 293 ? 102.337 138.730 150.254 1.00 74.32  ? 324 ALA A CA  1 
ATOM   1686 C C   . ALA A 1 293 ? 103.247 137.657 150.846 1.00 75.00  ? 324 ALA A C   1 
ATOM   1687 O O   . ALA A 1 293 ? 103.504 137.657 152.055 1.00 75.74  ? 324 ALA A O   1 
ATOM   1688 C CB  . ALA A 1 293 ? 100.871 138.312 150.362 1.00 77.42  ? 324 ALA A CB  1 
ATOM   1689 N N   . ASP A 1 294 ? 103.742 136.737 150.019 1.00 76.03  ? 325 ASP A N   1 
ATOM   1690 C CA  . ASP A 1 294 ? 104.482 135.575 150.500 1.00 76.02  ? 325 ASP A CA  1 
ATOM   1691 C C   . ASP A 1 294 ? 105.983 135.800 150.628 1.00 72.21  ? 325 ASP A C   1 
ATOM   1692 O O   . ASP A 1 294 ? 106.694 134.863 151.006 1.00 74.59  ? 325 ASP A O   1 
ATOM   1693 C CB  . ASP A 1 294 ? 104.243 134.373 149.582 1.00 76.95  ? 325 ASP A CB  1 
ATOM   1694 C CG  . ASP A 1 294 ? 102.916 133.695 149.844 1.00 80.88  ? 325 ASP A CG  1 
ATOM   1695 O OD1 . ASP A 1 294 ? 102.254 134.044 150.843 1.00 81.65  ? 325 ASP A OD1 1 
ATOM   1696 O OD2 . ASP A 1 294 ? 102.531 132.813 149.049 1.00 81.34  ? 325 ASP A OD2 1 
ATOM   1697 N N   . LEU A 1 295 ? 106.485 136.985 150.305 1.00 66.70  ? 326 LEU A N   1 
ATOM   1698 C CA  . LEU A 1 295 ? 107.898 137.277 150.506 1.00 64.26  ? 326 LEU A CA  1 
ATOM   1699 C C   . LEU A 1 295 ? 108.192 137.488 151.989 1.00 64.12  ? 326 LEU A C   1 
ATOM   1700 O O   . LEU A 1 295 ? 107.286 137.845 152.753 1.00 67.10  ? 326 LEU A O   1 
ATOM   1701 C CB  . LEU A 1 295 ? 108.293 138.522 149.717 1.00 62.60  ? 326 LEU A CB  1 
ATOM   1702 C CG  . LEU A 1 295 ? 108.274 138.409 148.210 1.00 64.24  ? 326 LEU A CG  1 
ATOM   1703 C CD1 . LEU A 1 295 ? 108.507 139.755 147.654 1.00 57.97  ? 326 LEU A CD1 1 
ATOM   1704 C CD2 . LEU A 1 295 ? 109.373 137.490 147.755 1.00 61.68  ? 326 LEU A CD2 1 
ATOM   1705 N N   . PRO A 1 296 ? 109.430 137.270 152.437 1.00 57.69  ? 327 PRO A N   1 
ATOM   1706 C CA  . PRO A 1 296 ? 109.796 137.677 153.795 1.00 51.47  ? 327 PRO A CA  1 
ATOM   1707 C C   . PRO A 1 296 ? 109.924 139.187 153.917 1.00 52.36  ? 327 PRO A C   1 
ATOM   1708 O O   . PRO A 1 296 ? 109.999 139.921 152.930 1.00 56.51  ? 327 PRO A O   1 
ATOM   1709 C CB  . PRO A 1 296 ? 111.146 136.991 154.020 1.00 55.06  ? 327 PRO A CB  1 
ATOM   1710 C CG  . PRO A 1 296 ? 111.144 135.857 153.072 1.00 65.48  ? 327 PRO A CG  1 
ATOM   1711 C CD  . PRO A 1 296 ? 110.468 136.395 151.861 1.00 61.38  ? 327 PRO A CD  1 
ATOM   1712 N N   . ASN A 1 297 ? 109.918 139.642 155.165 1.00 54.02  ? 328 ASN A N   1 
ATOM   1713 C CA  . ASN A 1 297 ? 110.108 141.049 155.479 1.00 50.11  ? 328 ASN A CA  1 
ATOM   1714 C C   . ASN A 1 297 ? 111.554 141.460 155.212 1.00 45.18  ? 328 ASN A C   1 
ATOM   1715 O O   . ASN A 1 297 ? 112.486 140.689 155.463 1.00 49.45  ? 328 ASN A O   1 
ATOM   1716 C CB  . ASN A 1 297 ? 109.727 141.300 156.939 1.00 49.66  ? 328 ASN A CB  1 
ATOM   1717 C CG  . ASN A 1 297 ? 109.766 142.758 157.317 1.00 52.12  ? 328 ASN A CG  1 
ATOM   1718 O OD1 . ASN A 1 297 ? 109.529 143.631 156.489 1.00 57.93  ? 328 ASN A OD1 1 
ATOM   1719 N ND2 . ASN A 1 297 ? 110.057 143.031 158.583 1.00 49.04  ? 328 ASN A ND2 1 
ATOM   1720 N N   . ARG A 1 298 ? 111.705 142.687 154.679 1.00 39.67  ? 329 ARG A N   1 
ATOM   1721 C CA  . ARG A 1 298 ? 112.962 143.310 154.211 1.00 45.36  ? 329 ARG A CA  1 
ATOM   1722 C C   . ARG A 1 298 ? 113.674 142.463 153.156 1.00 44.46  ? 329 ARG A C   1 
ATOM   1723 O O   . ARG A 1 298 ? 114.892 142.285 153.187 1.00 47.63  ? 329 ARG A O   1 
ATOM   1724 C CB  . ARG A 1 298 ? 113.896 143.671 155.371 1.00 48.20  ? 329 ARG A CB  1 
ATOM   1725 C CG  . ARG A 1 298 ? 113.473 144.928 156.105 1.00 46.20  ? 329 ARG A CG  1 
ATOM   1726 C CD  . ARG A 1 298 ? 114.540 145.402 157.068 1.00 49.18  ? 329 ARG A CD  1 
ATOM   1727 N NE  . ARG A 1 298 ? 113.994 146.297 158.081 1.00 56.43  ? 329 ARG A NE  1 
ATOM   1728 C CZ  . ARG A 1 298 ? 114.713 146.878 159.032 1.00 59.51  ? 329 ARG A CZ  1 
ATOM   1729 N NH1 . ARG A 1 298 ? 116.017 146.683 159.129 1.00 61.63  ? 329 ARG A NH1 1 
ATOM   1730 N NH2 . ARG A 1 298 ? 114.108 147.680 159.904 1.00 53.90  ? 329 ARG A NH2 1 
ATOM   1731 N N   . ALA A 1 299 ? 112.900 141.946 152.209 1.00 35.76  ? 330 ALA A N   1 
ATOM   1732 C CA  . ALA A 1 299 ? 113.425 141.230 151.057 1.00 33.79  ? 330 ALA A CA  1 
ATOM   1733 C C   . ALA A 1 299 ? 113.448 142.170 149.864 1.00 33.22  ? 330 ALA A C   1 
ATOM   1734 O O   . ALA A 1 299 ? 112.623 143.083 149.778 1.00 38.35  ? 330 ALA A O   1 
ATOM   1735 C CB  . ALA A 1 299 ? 112.583 139.998 150.736 1.00 39.25  ? 330 ALA A CB  1 
ATOM   1736 N N   . PHE A 1 300 ? 114.390 141.950 148.951 1.00 30.42  ? 331 PHE A N   1 
ATOM   1737 C CA  . PHE A 1 300 ? 114.546 142.816 147.790 1.00 27.73  ? 331 PHE A CA  1 
ATOM   1738 C C   . PHE A 1 300 ? 113.957 142.144 146.558 1.00 30.96  ? 331 PHE A C   1 
ATOM   1739 O O   . PHE A 1 300 ? 114.191 140.956 146.322 1.00 36.09  ? 331 PHE A O   1 
ATOM   1740 C CB  . PHE A 1 300 ? 116.011 143.149 147.558 1.00 28.13  ? 331 PHE A CB  1 
ATOM   1741 C CG  . PHE A 1 300 ? 116.600 144.059 148.585 1.00 27.50  ? 331 PHE A CG  1 
ATOM   1742 C CD1 . PHE A 1 300 ? 116.525 145.440 148.425 1.00 26.49  ? 331 PHE A CD1 1 
ATOM   1743 C CD2 . PHE A 1 300 ? 117.248 143.535 149.703 1.00 30.47  ? 331 PHE A CD2 1 
ATOM   1744 C CE1 . PHE A 1 300 ? 117.080 146.295 149.373 1.00 27.83  ? 331 PHE A CE1 1 
ATOM   1745 C CE2 . PHE A 1 300 ? 117.804 144.375 150.659 1.00 32.86  ? 331 PHE A CE2 1 
ATOM   1746 C CZ  . PHE A 1 300 ? 117.718 145.757 150.491 1.00 30.57  ? 331 PHE A CZ  1 
ATOM   1747 N N   . VAL A 1 301 ? 113.194 142.905 145.773 1.00 30.74  ? 332 VAL A N   1 
ATOM   1748 C CA  . VAL A 1 301 ? 112.482 142.392 144.607 1.00 27.73  ? 332 VAL A CA  1 
ATOM   1749 C C   . VAL A 1 301 ? 113.098 143.019 143.372 1.00 32.12  ? 332 VAL A C   1 
ATOM   1750 O O   . VAL A 1 301 ? 113.084 144.244 143.237 1.00 36.33  ? 332 VAL A O   1 
ATOM   1751 C CB  . VAL A 1 301 ? 110.991 142.739 144.659 1.00 27.86  ? 332 VAL A CB  1 
ATOM   1752 C CG1 . VAL A 1 301 ? 110.242 141.978 143.583 1.00 32.37  ? 332 VAL A CG1 1 
ATOM   1753 C CG2 . VAL A 1 301 ? 110.427 142.541 146.029 1.00 33.17  ? 332 VAL A CG2 1 
ATOM   1754 N N   . LEU A 1 302 ? 113.591 142.210 142.441 1.00 32.71  ? 333 LEU A N   1 
ATOM   1755 C CA  . LEU A 1 302 ? 114.211 142.748 141.228 1.00 32.61  ? 333 LEU A CA  1 
ATOM   1756 C C   . LEU A 1 302 ? 113.294 142.460 140.042 1.00 34.83  ? 333 LEU A C   1 
ATOM   1757 O O   . LEU A 1 302 ? 113.360 141.400 139.423 1.00 35.97  ? 333 LEU A O   1 
ATOM   1758 C CB  . LEU A 1 302 ? 115.611 142.183 141.015 1.00 31.15  ? 333 LEU A CB  1 
ATOM   1759 C CG  . LEU A 1 302 ? 116.763 142.813 141.814 1.00 34.67  ? 333 LEU A CG  1 
ATOM   1760 C CD1 . LEU A 1 302 ? 116.938 142.242 143.222 1.00 34.90  ? 333 LEU A CD1 1 
ATOM   1761 C CD2 . LEU A 1 302 ? 118.065 142.752 141.041 1.00 38.31  ? 333 LEU A CD2 1 
ATOM   1762 N N   . MET A 1 303 ? 112.453 143.437 139.705 1.00 35.46  ? 334 MET A N   1 
ATOM   1763 C CA  . MET A 1 303 ? 111.386 143.271 138.729 1.00 34.65  ? 334 MET A CA  1 
ATOM   1764 C C   . MET A 1 303 ? 111.388 144.427 137.742 1.00 38.87  ? 334 MET A C   1 
ATOM   1765 O O   . MET A 1 303 ? 112.074 145.429 137.948 1.00 44.48  ? 334 MET A O   1 
ATOM   1766 C CB  . MET A 1 303 ? 110.023 143.199 139.419 1.00 35.36  ? 334 MET A CB  1 
ATOM   1767 C CG  . MET A 1 303 ? 109.571 144.529 139.995 1.00 36.45  ? 334 MET A CG  1 
ATOM   1768 S SD  . MET A 1 303 ? 107.830 144.631 140.444 1.00 50.21  ? 334 MET A SD  1 
ATOM   1769 C CE  . MET A 1 303 ? 107.531 143.001 141.102 1.00 49.03  ? 334 MET A CE  1 
ATOM   1770 N N   . GLU A 1 304 ? 110.630 144.277 136.660 1.00 39.78  ? 335 GLU A N   1 
ATOM   1771 C CA  . GLU A 1 304 ? 110.418 145.381 135.737 1.00 40.86  ? 335 GLU A CA  1 
ATOM   1772 C C   . GLU A 1 304 ? 108.992 145.897 135.847 1.00 45.38  ? 335 GLU A C   1 
ATOM   1773 O O   . GLU A 1 304 ? 108.072 145.166 136.215 1.00 50.69  ? 335 GLU A O   1 
ATOM   1774 C CB  . GLU A 1 304 ? 110.695 144.948 134.305 1.00 40.02  ? 335 GLU A CB  1 
ATOM   1775 C CG  . GLU A 1 304 ? 110.149 143.588 133.966 1.00 42.13  ? 335 GLU A CG  1 
ATOM   1776 C CD  . GLU A 1 304 ? 110.525 143.151 132.571 1.00 48.31  ? 335 GLU A CD  1 
ATOM   1777 O OE1 . GLU A 1 304 ? 111.132 143.961 131.841 1.00 48.36  ? 335 GLU A OE1 1 
ATOM   1778 O OE2 . GLU A 1 304 ? 110.212 142.000 132.199 1.00 51.40  ? 335 GLU A OE2 1 
ATOM   1779 N N   . ASN A 1 305 ? 108.812 147.171 135.517 1.00 45.08  ? 336 ASN A N   1 
ATOM   1780 C CA  . ASN A 1 305 ? 107.510 147.818 135.582 1.00 49.57  ? 336 ASN A CA  1 
ATOM   1781 C C   . ASN A 1 305 ? 106.654 147.381 134.403 1.00 54.69  ? 336 ASN A C   1 
ATOM   1782 O O   . ASN A 1 305 ? 107.094 147.455 133.253 1.00 54.00  ? 336 ASN A O   1 
ATOM   1783 C CB  . ASN A 1 305 ? 107.644 149.336 135.571 1.00 47.62  ? 336 ASN A CB  1 
ATOM   1784 C CG  . ASN A 1 305 ? 108.132 149.879 136.873 1.00 54.67  ? 336 ASN A CG  1 
ATOM   1785 O OD1 . ASN A 1 305 ? 107.874 149.313 137.932 1.00 58.86  ? 336 ASN A OD1 1 
ATOM   1786 N ND2 . ASN A 1 305 ? 108.806 151.013 136.813 1.00 60.67  ? 336 ASN A ND2 1 
ATOM   1787 N N   . GLU A 1 306 ? 105.431 146.950 134.687 1.00 52.23  ? 337 GLU A N   1 
ATOM   1788 C CA  . GLU A 1 306 ? 104.454 146.759 133.629 1.00 47.83  ? 337 GLU A CA  1 
ATOM   1789 C C   . GLU A 1 306 ? 103.898 148.110 133.201 1.00 50.38  ? 337 GLU A C   1 
ATOM   1790 O O   . GLU A 1 306 ? 103.429 148.889 134.035 1.00 50.45  ? 337 GLU A O   1 
ATOM   1791 C CB  . GLU A 1 306 ? 103.331 145.843 134.102 1.00 48.86  ? 337 GLU A CB  1 
ATOM   1792 C CG  . GLU A 1 306 ? 103.801 144.472 134.544 1.00 54.45  ? 337 GLU A CG  1 
ATOM   1793 C CD  . GLU A 1 306 ? 102.730 143.701 135.290 1.00 62.23  ? 337 GLU A CD  1 
ATOM   1794 O OE1 . GLU A 1 306 ? 101.537 143.871 134.964 1.00 59.87  ? 337 GLU A OE1 1 
ATOM   1795 O OE2 . GLU A 1 306 ? 103.081 142.928 136.205 1.00 64.91  ? 337 GLU A OE2 1 
ATOM   1796 N N   . ILE A 1 307 ? 103.961 148.394 131.899 1.00 48.52  ? 338 ILE A N   1 
ATOM   1797 C CA  . ILE A 1 307 ? 103.532 149.692 131.398 1.00 45.37  ? 338 ILE A CA  1 
ATOM   1798 C C   . ILE A 1 307 ? 102.050 149.644 131.055 1.00 47.46  ? 338 ILE A C   1 
ATOM   1799 O O   . ILE A 1 307 ? 101.627 148.935 130.138 1.00 50.91  ? 338 ILE A O   1 
ATOM   1800 C CB  . ILE A 1 307 ? 104.357 150.090 130.165 1.00 42.30  ? 338 ILE A CB  1 
ATOM   1801 C CG1 . ILE A 1 307 ? 105.829 150.196 130.521 1.00 43.68  ? 338 ILE A CG1 1 
ATOM   1802 C CG2 . ILE A 1 307 ? 103.882 151.423 129.632 1.00 43.47  ? 338 ILE A CG2 1 
ATOM   1803 C CD1 . ILE A 1 307 ? 106.707 150.316 129.317 1.00 45.19  ? 338 ILE A CD1 1 
ATOM   1804 N N   . ASP A 1 308 ? 101.255 150.431 131.769 1.00 46.32  ? 339 ASP A N   1 
ATOM   1805 C CA  . ASP A 1 308 ? 99.804  150.405 131.640 1.00 47.98  ? 339 ASP A CA  1 
ATOM   1806 C C   . ASP A 1 308 ? 99.386  151.215 130.420 1.00 50.57  ? 339 ASP A C   1 
ATOM   1807 O O   . ASP A 1 308 ? 99.704  152.403 130.322 1.00 54.92  ? 339 ASP A O   1 
ATOM   1808 C CB  . ASP A 1 308 ? 99.141  150.948 132.904 1.00 52.22  ? 339 ASP A CB  1 
ATOM   1809 C CG  . ASP A 1 308 ? 98.919  149.874 133.948 1.00 58.80  ? 339 ASP A CG  1 
ATOM   1810 O OD1 . ASP A 1 308 ? 99.538  149.958 135.030 1.00 59.12  ? 339 ASP A OD1 1 
ATOM   1811 O OD2 . ASP A 1 308 ? 98.124  148.946 133.690 1.00 61.49  ? 339 ASP A OD2 1 
ATOM   1812 N N   . LEU A 1 309 ? 98.668  150.569 129.503 1.00 48.90  ? 340 LEU A N   1 
ATOM   1813 C CA  . LEU A 1 309 ? 98.206  151.198 128.271 1.00 48.78  ? 340 LEU A CA  1 
ATOM   1814 C C   . LEU A 1 309 ? 96.795  151.730 128.477 1.00 51.22  ? 340 LEU A C   1 
ATOM   1815 O O   . LEU A 1 309 ? 95.884  150.961 128.797 1.00 53.46  ? 340 LEU A O   1 
ATOM   1816 C CB  . LEU A 1 309 ? 98.218  150.194 127.122 1.00 45.56  ? 340 LEU A CB  1 
ATOM   1817 C CG  . LEU A 1 309 ? 99.494  149.401 126.857 1.00 44.69  ? 340 LEU A CG  1 
ATOM   1818 C CD1 . LEU A 1 309 ? 99.279  148.489 125.674 1.00 44.64  ? 340 LEU A CD1 1 
ATOM   1819 C CD2 . LEU A 1 309 ? 100.669 150.325 126.607 1.00 42.63  ? 340 LEU A CD2 1 
ATOM   1820 N N   . SER A 1 310 ? 96.610  153.037 128.306 1.00 54.11  ? 341 SER A N   1 
ATOM   1821 C CA  . SER A 1 310 ? 95.265  153.591 128.392 1.00 57.45  ? 341 SER A CA  1 
ATOM   1822 C C   . SER A 1 310 ? 94.833  154.269 127.097 1.00 62.52  ? 341 SER A C   1 
ATOM   1823 O O   . SER A 1 310 ? 93.800  153.913 126.523 1.00 64.52  ? 341 SER A O   1 
ATOM   1824 C CB  . SER A 1 310 ? 95.173  154.579 129.554 1.00 60.75  ? 341 SER A CB  1 
ATOM   1825 O OG  . SER A 1 310 ? 93.907  155.214 129.580 1.00 59.64  ? 341 SER A OG  1 
ATOM   1826 N N   . THR A 1 311 ? 95.606  155.252 126.630 1.00 64.63  ? 342 THR A N   1 
ATOM   1827 C CA  . THR A 1 311 ? 95.265  156.008 125.428 1.00 66.45  ? 342 THR A CA  1 
ATOM   1828 C C   . THR A 1 311 ? 96.456  156.021 124.480 1.00 67.27  ? 342 THR A C   1 
ATOM   1829 O O   . THR A 1 311 ? 97.567  155.621 124.835 1.00 66.23  ? 342 THR A O   1 
ATOM   1830 C CB  . THR A 1 311 ? 94.838  157.462 125.723 1.00 68.48  ? 342 THR A CB  1 
ATOM   1831 O OG1 . THR A 1 311 ? 95.910  158.169 126.357 1.00 68.65  ? 342 THR A OG1 1 
ATOM   1832 C CG2 . THR A 1 311 ? 93.559  157.559 126.562 1.00 64.46  ? 342 THR A CG2 1 
ATOM   1833 N N   . ALA A 1 312 ? 96.200  156.490 123.255 1.00 66.63  ? 343 ALA A N   1 
ATOM   1834 C CA  . ALA A 1 312 ? 97.220  156.467 122.213 1.00 64.72  ? 343 ALA A CA  1 
ATOM   1835 C C   . ALA A 1 312 ? 98.079  157.721 122.215 1.00 68.69  ? 343 ALA A C   1 
ATOM   1836 O O   . ALA A 1 312 ? 99.124  157.750 121.557 1.00 70.93  ? 343 ALA A O   1 
ATOM   1837 C CB  . ALA A 1 312 ? 96.569  156.294 120.845 1.00 64.39  ? 343 ALA A CB  1 
ATOM   1838 N N   . VAL A 1 313 ? 97.668  158.766 122.939 1.00 70.40  ? 344 VAL A N   1 
ATOM   1839 C CA  . VAL A 1 313 ? 98.450  160.002 122.962 1.00 74.29  ? 344 VAL A CA  1 
ATOM   1840 C C   . VAL A 1 313 ? 99.592  159.898 123.966 1.00 73.67  ? 344 VAL A C   1 
ATOM   1841 O O   . VAL A 1 313 ? 100.533 160.700 123.945 1.00 71.54  ? 344 VAL A O   1 
ATOM   1842 C CB  . VAL A 1 313 ? 97.543  161.210 123.257 1.00 75.68  ? 344 VAL A CB  1 
ATOM   1843 C CG1 . VAL A 1 313 ? 96.710  161.555 122.037 1.00 77.19  ? 344 VAL A CG1 1 
ATOM   1844 C CG2 . VAL A 1 313 ? 96.650  160.917 124.448 1.00 73.17  ? 344 VAL A CG2 1 
ATOM   1845 N N   . GLU A 1 314 ? 99.527  158.908 124.860 1.00 73.10  ? 345 GLU A N   1 
ATOM   1846 C CA  . GLU A 1 314 ? 100.619 158.663 125.794 1.00 70.16  ? 345 GLU A CA  1 
ATOM   1847 C C   . GLU A 1 314 ? 101.743 157.865 125.145 1.00 68.49  ? 345 GLU A C   1 
ATOM   1848 O O   . GLU A 1 314 ? 102.844 157.775 125.697 1.00 71.45  ? 345 GLU A O   1 
ATOM   1849 C CB  . GLU A 1 314 ? 100.087 157.928 127.022 1.00 69.62  ? 345 GLU A CB  1 
ATOM   1850 C CG  . GLU A 1 314 ? 98.954  158.648 127.722 1.00 71.80  ? 345 GLU A CG  1 
ATOM   1851 C CD  . GLU A 1 314 ? 98.220  157.758 128.706 1.00 74.10  ? 345 GLU A CD  1 
ATOM   1852 O OE1 . GLU A 1 314 ? 98.553  156.556 128.786 1.00 69.56  ? 345 GLU A OE1 1 
ATOM   1853 O OE2 . GLU A 1 314 ? 97.303  158.256 129.392 1.00 76.93  ? 345 GLU A OE2 1 
ATOM   1854 N N   . LEU A 1 315 ? 101.481 157.254 123.985 1.00 66.30  ? 346 LEU A N   1 
ATOM   1855 C CA  . LEU A 1 315 ? 102.491 156.421 123.341 1.00 64.38  ? 346 LEU A CA  1 
ATOM   1856 C C   . LEU A 1 315 ? 103.427 157.252 122.473 1.00 69.09  ? 346 LEU A C   1 
ATOM   1857 O O   . LEU A 1 315 ? 104.642 157.026 122.469 1.00 76.18  ? 346 LEU A O   1 
ATOM   1858 C CB  . LEU A 1 315 ? 101.821 155.327 122.515 1.00 61.78  ? 346 LEU A CB  1 
ATOM   1859 C CG  . LEU A 1 315 ? 100.663 154.578 123.175 1.00 63.57  ? 346 LEU A CG  1 
ATOM   1860 C CD1 . LEU A 1 315 ? 100.004 153.651 122.182 1.00 60.41  ? 346 LEU A CD1 1 
ATOM   1861 C CD2 . LEU A 1 315 ? 101.117 153.797 124.388 1.00 63.81  ? 346 LEU A CD2 1 
ATOM   1862 N N   . ASP A 1 316 ? 102.882 158.211 121.722 1.00 68.51  ? 347 ASP A N   1 
ATOM   1863 C CA  . ASP A 1 316 ? 103.676 159.063 120.844 1.00 67.41  ? 347 ASP A CA  1 
ATOM   1864 C C   . ASP A 1 316 ? 102.950 160.379 120.614 1.00 69.64  ? 347 ASP A C   1 
ATOM   1865 O O   . ASP A 1 316 ? 101.722 160.451 120.703 1.00 71.75  ? 347 ASP A O   1 
ATOM   1866 C CB  . ASP A 1 316 ? 103.951 158.387 119.497 1.00 67.74  ? 347 ASP A CB  1 
ATOM   1867 C CG  . ASP A 1 316 ? 105.175 158.941 118.804 1.00 71.01  ? 347 ASP A CG  1 
ATOM   1868 O OD1 . ASP A 1 316 ? 105.913 159.704 119.453 1.00 70.05  ? 347 ASP A OD1 1 
ATOM   1869 O OD2 . ASP A 1 316 ? 105.400 158.616 117.620 1.00 74.22  ? 347 ASP A OD2 1 
ATOM   1870 N N   . ALA A 1 317 ? 103.725 161.422 120.301 1.00 66.23  ? 348 ALA A N   1 
ATOM   1871 C CA  . ALA A 1 317 ? 103.137 162.703 119.923 1.00 66.50  ? 348 ALA A CA  1 
ATOM   1872 C C   . ALA A 1 317 ? 102.621 162.679 118.489 1.00 69.12  ? 348 ALA A C   1 
ATOM   1873 O O   . ALA A 1 317 ? 101.801 163.524 118.109 1.00 68.48  ? 348 ALA A O   1 
ATOM   1874 C CB  . ALA A 1 317 ? 104.156 163.823 120.107 1.00 67.37  ? 348 ALA A CB  1 
ATOM   1875 N N   . THR A 1 318 ? 103.123 161.753 117.672 1.00 71.41  ? 349 THR A N   1 
ATOM   1876 C CA  . THR A 1 318 ? 102.537 161.485 116.365 1.00 69.92  ? 349 THR A CA  1 
ATOM   1877 C C   . THR A 1 318 ? 101.165 160.836 116.556 1.00 69.45  ? 349 THR A C   1 
ATOM   1878 O O   . THR A 1 318 ? 101.048 159.880 117.334 1.00 69.23  ? 349 THR A O   1 
ATOM   1879 C CB  . THR A 1 318 ? 103.457 160.563 115.558 1.00 66.07  ? 349 THR A CB  1 
ATOM   1880 O OG1 . THR A 1 318 ? 104.750 161.168 115.436 1.00 66.67  ? 349 THR A OG1 1 
ATOM   1881 C CG2 . THR A 1 318 ? 102.911 160.322 114.166 1.00 68.09  ? 349 THR A CG2 1 
ATOM   1882 N N   . PRO A 1 319 ? 100.105 161.355 115.915 1.00 68.98  ? 350 PRO A N   1 
ATOM   1883 C CA  . PRO A 1 319 ? 98.746  160.868 116.216 1.00 68.43  ? 350 PRO A CA  1 
ATOM   1884 C C   . PRO A 1 319 ? 98.449  159.492 115.627 1.00 68.56  ? 350 PRO A C   1 
ATOM   1885 O O   . PRO A 1 319 ? 98.270  159.327 114.419 1.00 69.21  ? 350 PRO A O   1 
ATOM   1886 C CB  . PRO A 1 319 ? 97.841  161.950 115.613 1.00 69.27  ? 350 PRO A CB  1 
ATOM   1887 C CG  . PRO A 1 319 ? 98.677  162.643 114.598 1.00 70.40  ? 350 PRO A CG  1 
ATOM   1888 C CD  . PRO A 1 319 ? 100.068 162.604 115.127 1.00 69.17  ? 350 PRO A CD  1 
ATOM   1889 N N   . THR A 1 320 ? 98.410  158.497 116.511 1.00 66.67  ? 351 THR A N   1 
ATOM   1890 C CA  . THR A 1 320 ? 98.103  157.123 116.145 1.00 61.31  ? 351 THR A CA  1 
ATOM   1891 C C   . THR A 1 320 ? 96.848  156.699 116.893 1.00 61.47  ? 351 THR A C   1 
ATOM   1892 O O   . THR A 1 320 ? 96.188  157.509 117.548 1.00 61.12  ? 351 THR A O   1 
ATOM   1893 C CB  . THR A 1 320 ? 99.263  156.175 116.466 1.00 58.98  ? 351 THR A CB  1 
ATOM   1894 O OG1 . THR A 1 320 ? 99.584  156.260 117.859 1.00 57.44  ? 351 THR A OG1 1 
ATOM   1895 C CG2 . THR A 1 320 ? 100.496 156.532 115.658 1.00 60.06  ? 351 THR A CG2 1 
ATOM   1896 N N   . ALA A 1 321 ? 96.522  155.412 116.794 1.00 61.80  ? 352 ALA A N   1 
ATOM   1897 C CA  . ALA A 1 321 ? 95.343  154.856 117.444 1.00 60.41  ? 352 ALA A CA  1 
ATOM   1898 C C   . ALA A 1 321 ? 95.705  153.561 118.152 1.00 57.26  ? 352 ALA A C   1 
ATOM   1899 O O   . ALA A 1 321 ? 96.381  152.703 117.579 1.00 55.07  ? 352 ALA A O   1 
ATOM   1900 C CB  . ALA A 1 321 ? 94.219  154.606 116.436 1.00 59.71  ? 352 ALA A CB  1 
ATOM   1901 N N   . LEU A 1 322 ? 95.256  153.426 119.395 1.00 57.59  ? 353 LEU A N   1 
ATOM   1902 C CA  . LEU A 1 322 ? 95.428  152.188 120.137 1.00 58.16  ? 353 LEU A CA  1 
ATOM   1903 C C   . LEU A 1 322 ? 94.171  151.338 119.991 1.00 59.18  ? 353 LEU A C   1 
ATOM   1904 O O   . LEU A 1 322 ? 93.053  151.861 119.989 1.00 62.39  ? 353 LEU A O   1 
ATOM   1905 C CB  . LEU A 1 322 ? 95.712  152.484 121.610 1.00 58.64  ? 353 LEU A CB  1 
ATOM   1906 C CG  . LEU A 1 322 ? 96.128  151.333 122.525 1.00 55.74  ? 353 LEU A CG  1 
ATOM   1907 C CD1 . LEU A 1 322 ? 97.474  150.786 122.106 1.00 50.45  ? 353 LEU A CD1 1 
ATOM   1908 C CD2 . LEU A 1 322 ? 96.167  151.791 123.964 1.00 57.30  ? 353 LEU A CD2 1 
ATOM   1909 N N   . ASP A 1 323 ? 94.365  150.029 119.842 1.00 55.80  ? 354 ASP A N   1 
ATOM   1910 C CA  . ASP A 1 323 ? 93.271  149.111 119.568 1.00 58.28  ? 354 ASP A CA  1 
ATOM   1911 C C   . ASP A 1 323 ? 92.432  148.870 120.820 1.00 60.20  ? 354 ASP A C   1 
ATOM   1912 O O   . ASP A 1 323 ? 92.888  149.052 121.950 1.00 60.82  ? 354 ASP A O   1 
ATOM   1913 C CB  . ASP A 1 323 ? 93.820  147.790 119.038 1.00 55.56  ? 354 ASP A CB  1 
ATOM   1914 C CG  . ASP A 1 323 ? 94.370  147.916 117.636 1.00 61.80  ? 354 ASP A CG  1 
ATOM   1915 O OD1 . ASP A 1 323 ? 93.935  148.830 116.905 1.00 67.51  ? 354 ASP A OD1 1 
ATOM   1916 O OD2 . ASP A 1 323 ? 95.254  147.118 117.268 1.00 61.19  ? 354 ASP A OD2 1 
ATOM   1917 N N   . GLU A 1 324 ? 91.189  148.426 120.605 1.00 62.40  ? 355 GLU A N   1 
ATOM   1918 C CA  . GLU A 1 324 ? 90.240  148.301 121.710 1.00 64.86  ? 355 GLU A CA  1 
ATOM   1919 C C   . GLU A 1 324 ? 90.463  147.022 122.508 1.00 62.26  ? 355 GLU A C   1 
ATOM   1920 O O   . GLU A 1 324 ? 89.913  146.863 123.604 1.00 64.05  ? 355 GLU A O   1 
ATOM   1921 C CB  . GLU A 1 324 ? 88.809  148.358 121.180 1.00 72.45  ? 355 GLU A CB  1 
ATOM   1922 C CG  . GLU A 1 324 ? 88.457  149.682 120.527 1.00 77.22  ? 355 GLU A CG  1 
ATOM   1923 C CD  . GLU A 1 324 ? 87.036  149.721 120.007 1.00 89.04  ? 355 GLU A CD  1 
ATOM   1924 O OE1 . GLU A 1 324 ? 86.308  148.722 120.185 1.00 89.73  ? 355 GLU A OE1 1 
ATOM   1925 O OE2 . GLU A 1 324 ? 86.646  150.753 119.422 1.00 94.60  ? 355 GLU A OE2 1 
ATOM   1926 N N   . ILE A 1 325 ? 91.256  146.094 121.973 1.00 57.64  ? 356 ILE A N   1 
ATOM   1927 C CA  . ILE A 1 325 ? 91.645  144.907 122.722 1.00 56.06  ? 356 ILE A CA  1 
ATOM   1928 C C   . ILE A 1 325 ? 92.804  145.239 123.669 1.00 56.35  ? 356 ILE A C   1 
ATOM   1929 O O   . ILE A 1 325 ? 93.005  144.563 124.686 1.00 56.74  ? 356 ILE A O   1 
ATOM   1930 C CB  . ILE A 1 325 ? 91.949  143.775 121.704 1.00 57.37  ? 356 ILE A CB  1 
ATOM   1931 C CG1 . ILE A 1 325 ? 92.121  142.395 122.348 1.00 57.08  ? 356 ILE A CG1 1 
ATOM   1932 C CG2 . ILE A 1 325 ? 93.133  144.124 120.806 1.00 57.72  ? 356 ILE A CG2 1 
ATOM   1933 C CD1 . ILE A 1 325 ? 92.218  141.275 121.334 1.00 56.69  ? 356 ILE A CD1 1 
ATOM   1934 N N   . LEU A 1 326 ? 93.523  146.334 123.408 1.00 54.23  ? 357 LEU A N   1 
ATOM   1935 C CA  . LEU A 1 326 ? 94.706  146.695 124.177 1.00 50.51  ? 357 LEU A CA  1 
ATOM   1936 C C   . LEU A 1 326 ? 94.471  147.795 125.202 1.00 51.24  ? 357 LEU A C   1 
ATOM   1937 O O   . LEU A 1 326 ? 95.384  148.088 125.978 1.00 51.77  ? 357 LEU A O   1 
ATOM   1938 C CB  . LEU A 1 326 ? 95.826  147.143 123.244 1.00 49.62  ? 357 LEU A CB  1 
ATOM   1939 C CG  . LEU A 1 326 ? 96.573  146.053 122.501 1.00 46.53  ? 357 LEU A CG  1 
ATOM   1940 C CD1 . LEU A 1 326 ? 97.208  146.667 121.284 1.00 44.36  ? 357 LEU A CD1 1 
ATOM   1941 C CD2 . LEU A 1 326 ? 97.613  145.438 123.410 1.00 43.74  ? 357 LEU A CD2 1 
ATOM   1942 N N   . ILE A 1 327 ? 93.298  148.426 125.219 1.00 53.83  ? 358 ILE A N   1 
ATOM   1943 C CA  . ILE A 1 327 ? 93.048  149.481 126.191 1.00 53.69  ? 358 ILE A CA  1 
ATOM   1944 C C   . ILE A 1 327 ? 92.708  148.858 127.536 1.00 52.90  ? 358 ILE A C   1 
ATOM   1945 O O   . ILE A 1 327 ? 91.746  148.091 127.665 1.00 53.55  ? 358 ILE A O   1 
ATOM   1946 C CB  . ILE A 1 327 ? 91.935  150.420 125.697 1.00 54.93  ? 358 ILE A CB  1 
ATOM   1947 C CG1 . ILE A 1 327 ? 92.422  151.212 124.488 1.00 55.18  ? 358 ILE A CG1 1 
ATOM   1948 C CG2 . ILE A 1 327 ? 91.492  151.378 126.791 1.00 55.60  ? 358 ILE A CG2 1 
ATOM   1949 C CD1 . ILE A 1 327 ? 91.335  151.979 123.779 1.00 57.62  ? 358 ILE A CD1 1 
ATOM   1950 N N   . GLY A 1 328 ? 93.511  149.180 128.546 1.00 52.31  ? 359 GLY A N   1 
ATOM   1951 C CA  . GLY A 1 328 ? 93.336  148.592 129.856 1.00 52.52  ? 359 GLY A CA  1 
ATOM   1952 C C   . GLY A 1 328 ? 94.233  147.411 130.133 1.00 53.39  ? 359 GLY A C   1 
ATOM   1953 O O   . GLY A 1 328 ? 94.027  146.707 131.125 1.00 60.37  ? 359 GLY A O   1 
ATOM   1954 N N   . LYS A 1 329 ? 95.228  147.171 129.284 1.00 50.27  ? 360 LYS A N   1 
ATOM   1955 C CA  . LYS A 1 329 ? 96.145  146.057 129.452 1.00 53.27  ? 360 LYS A CA  1 
ATOM   1956 C C   . LYS A 1 329 ? 97.541  146.605 129.701 1.00 53.56  ? 360 LYS A C   1 
ATOM   1957 O O   . LYS A 1 329 ? 97.812  147.784 129.470 1.00 53.78  ? 360 LYS A O   1 
ATOM   1958 C CB  . LYS A 1 329 ? 96.143  145.143 128.225 1.00 53.78  ? 360 LYS A CB  1 
ATOM   1959 C CG  . LYS A 1 329 ? 94.756  144.675 127.827 1.00 55.71  ? 360 LYS A CG  1 
ATOM   1960 C CD  . LYS A 1 329 ? 94.476  143.265 128.286 1.00 57.40  ? 360 LYS A CD  1 
ATOM   1961 C CE  . LYS A 1 329 ? 93.031  142.892 128.046 1.00 60.29  ? 360 LYS A CE  1 
ATOM   1962 N NZ  . LYS A 1 329 ? 92.706  141.577 128.660 1.00 68.44  ? 360 LYS A NZ  1 
ATOM   1963 N N   . SER A 1 330 ? 98.431  145.743 130.184 1.00 53.08  ? 361 SER A N   1 
ATOM   1964 C CA  . SER A 1 330 ? 99.784  146.145 130.542 1.00 48.54  ? 361 SER A CA  1 
ATOM   1965 C C   . SER A 1 330 ? 100.793 145.264 129.824 1.00 47.54  ? 361 SER A C   1 
ATOM   1966 O O   . SER A 1 330 ? 100.558 144.067 129.643 1.00 50.70  ? 361 SER A O   1 
ATOM   1967 C CB  . SER A 1 330 ? 100.002 146.078 132.053 1.00 52.03  ? 361 SER A CB  1 
ATOM   1968 O OG  . SER A 1 330 ? 99.510  144.865 132.587 1.00 56.64  ? 361 SER A OG  1 
ATOM   1969 N N   . VAL A 1 331 ? 101.918 145.857 129.430 1.00 45.49  ? 362 VAL A N   1 
ATOM   1970 C CA  . VAL A 1 331 ? 102.926 145.194 128.613 1.00 44.55  ? 362 VAL A CA  1 
ATOM   1971 C C   . VAL A 1 331 ? 104.214 145.092 129.411 1.00 44.87  ? 362 VAL A C   1 
ATOM   1972 O O   . VAL A 1 331 ? 104.412 145.837 130.375 1.00 49.10  ? 362 VAL A O   1 
ATOM   1973 C CB  . VAL A 1 331 ? 103.162 145.943 127.291 1.00 42.96  ? 362 VAL A CB  1 
ATOM   1974 C CG1 . VAL A 1 331 ? 101.938 145.847 126.438 1.00 45.12  ? 362 VAL A CG1 1 
ATOM   1975 C CG2 . VAL A 1 331 ? 103.499 147.398 127.536 1.00 41.84  ? 362 VAL A CG2 1 
ATOM   1976 N N   . LEU A 1 332 ? 105.071 144.166 129.028 1.00 42.29  ? 363 LEU A N   1 
ATOM   1977 C CA  . LEU A 1 332 ? 106.370 144.067 129.677 1.00 44.05  ? 363 LEU A CA  1 
ATOM   1978 C C   . LEU A 1 332 ? 107.458 144.594 128.745 1.00 43.29  ? 363 LEU A C   1 
ATOM   1979 O O   . LEU A 1 332 ? 107.440 144.291 127.553 1.00 43.57  ? 363 LEU A O   1 
ATOM   1980 C CB  . LEU A 1 332 ? 106.683 142.628 130.058 1.00 42.80  ? 363 LEU A CB  1 
ATOM   1981 C CG  . LEU A 1 332 ? 106.090 142.124 131.365 1.00 45.15  ? 363 LEU A CG  1 
ATOM   1982 C CD1 . LEU A 1 332 ? 106.351 140.643 131.504 1.00 48.80  ? 363 LEU A CD1 1 
ATOM   1983 C CD2 . LEU A 1 332 ? 106.688 142.885 132.522 1.00 46.62  ? 363 LEU A CD2 1 
ATOM   1984 N N   . PRO A 1 333 ? 108.415 145.377 129.262 1.00 39.89  ? 364 PRO A N   1 
ATOM   1985 C CA  . PRO A 1 333 ? 109.442 145.953 128.380 1.00 34.98  ? 364 PRO A CA  1 
ATOM   1986 C C   . PRO A 1 333 ? 110.502 144.965 127.936 1.00 35.64  ? 364 PRO A C   1 
ATOM   1987 O O   . PRO A 1 333 ? 111.195 145.219 126.945 1.00 37.11  ? 364 PRO A O   1 
ATOM   1988 C CB  . PRO A 1 333 ? 110.043 147.064 129.246 1.00 37.58  ? 364 PRO A CB  1 
ATOM   1989 C CG  . PRO A 1 333 ? 109.038 147.308 130.316 1.00 39.71  ? 364 PRO A CG  1 
ATOM   1990 C CD  . PRO A 1 333 ? 108.500 145.961 130.604 1.00 40.91  ? 364 PRO A CD  1 
ATOM   1991 N N   . SER A 1 334 ? 110.673 143.856 128.650 1.00 36.48  ? 365 SER A N   1 
ATOM   1992 C CA  . SER A 1 334 ? 111.559 142.808 128.159 1.00 38.55  ? 365 SER A CA  1 
ATOM   1993 C C   . SER A 1 334 ? 110.886 142.011 127.055 1.00 40.40  ? 365 SER A C   1 
ATOM   1994 O O   . SER A 1 334 ? 111.536 141.586 126.096 1.00 42.91  ? 365 SER A O   1 
ATOM   1995 C CB  . SER A 1 334 ? 111.974 141.885 129.296 1.00 42.78  ? 365 SER A CB  1 
ATOM   1996 O OG  . SER A 1 334 ? 110.844 141.328 129.940 1.00 45.04  ? 365 SER A OG  1 
ATOM   1997 N N   . ARG A 1 335 ? 109.578 141.793 127.179 1.00 41.98  ? 366 ARG A N   1 
ATOM   1998 C CA  . ARG A 1 335 ? 108.870 140.992 126.189 1.00 39.99  ? 366 ARG A CA  1 
ATOM   1999 C C   . ARG A 1 335 ? 108.476 141.823 124.977 1.00 37.75  ? 366 ARG A C   1 
ATOM   2000 O O   . ARG A 1 335 ? 108.136 141.268 123.929 1.00 40.57  ? 366 ARG A O   1 
ATOM   2001 C CB  . ARG A 1 335 ? 107.643 140.344 126.822 1.00 41.49  ? 366 ARG A CB  1 
ATOM   2002 C CG  . ARG A 1 335 ? 107.959 139.467 128.007 1.00 43.75  ? 366 ARG A CG  1 
ATOM   2003 C CD  . ARG A 1 335 ? 108.041 138.018 127.587 1.00 48.88  ? 366 ARG A CD  1 
ATOM   2004 N NE  . ARG A 1 335 ? 108.156 137.120 128.727 1.00 54.24  ? 366 ARG A NE  1 
ATOM   2005 C CZ  . ARG A 1 335 ? 108.520 135.849 128.638 1.00 58.86  ? 366 ARG A CZ  1 
ATOM   2006 N NH1 . ARG A 1 335 ? 108.816 135.296 127.474 1.00 62.11  ? 366 ARG A NH1 1 
ATOM   2007 N NH2 . ARG A 1 335 ? 108.589 135.115 129.744 1.00 59.42  ? 366 ARG A NH2 1 
ATOM   2008 N N   . VAL A 1 336 ? 108.499 143.151 125.096 1.00 34.12  ? 367 VAL A N   1 
ATOM   2009 C CA  . VAL A 1 336 ? 108.294 143.986 123.918 1.00 31.71  ? 367 VAL A CA  1 
ATOM   2010 C C   . VAL A 1 336 ? 109.584 144.066 123.113 1.00 35.03  ? 367 VAL A C   1 
ATOM   2011 O O   . VAL A 1 336 ? 109.596 143.768 121.916 1.00 38.77  ? 367 VAL A O   1 
ATOM   2012 C CB  . VAL A 1 336 ? 107.757 145.377 124.318 1.00 32.55  ? 367 VAL A CB  1 
ATOM   2013 C CG1 . VAL A 1 336 ? 107.979 146.418 123.236 1.00 33.93  ? 367 VAL A CG1 1 
ATOM   2014 C CG2 . VAL A 1 336 ? 106.276 145.305 124.568 1.00 35.75  ? 367 VAL A CG2 1 
ATOM   2015 N N   . LEU A 1 337 ? 110.703 144.389 123.777 1.00 37.02  ? 368 LEU A N   1 
ATOM   2016 C CA  . LEU A 1 337 ? 111.925 144.765 123.068 1.00 34.98  ? 368 LEU A CA  1 
ATOM   2017 C C   . LEU A 1 337 ? 112.682 143.553 122.539 1.00 35.49  ? 368 LEU A C   1 
ATOM   2018 O O   . LEU A 1 337 ? 113.500 143.683 121.622 1.00 34.86  ? 368 LEU A O   1 
ATOM   2019 C CB  . LEU A 1 337 ? 112.825 145.585 123.983 1.00 34.45  ? 368 LEU A CB  1 
ATOM   2020 C CG  . LEU A 1 337 ? 112.330 146.996 124.270 1.00 36.68  ? 368 LEU A CG  1 
ATOM   2021 C CD1 . LEU A 1 337 ? 113.195 147.627 125.336 1.00 38.05  ? 368 LEU A CD1 1 
ATOM   2022 C CD2 . LEU A 1 337 ? 112.321 147.830 123.007 1.00 36.58  ? 368 LEU A CD2 1 
ATOM   2023 N N   . SER A 1 338 ? 112.440 142.372 123.107 1.00 35.55  ? 369 SER A N   1 
ATOM   2024 C CA  . SER A 1 338 ? 112.972 141.160 122.497 1.00 35.70  ? 369 SER A CA  1 
ATOM   2025 C C   . SER A 1 338 ? 112.152 140.778 121.277 1.00 36.02  ? 369 SER A C   1 
ATOM   2026 O O   . SER A 1 338 ? 112.689 140.282 120.282 1.00 39.81  ? 369 SER A O   1 
ATOM   2027 C CB  . SER A 1 338 ? 112.998 140.016 123.508 1.00 42.15  ? 369 SER A CB  1 
ATOM   2028 O OG  . SER A 1 338 ? 111.742 139.368 123.569 1.00 46.84  ? 369 SER A OG  1 
ATOM   2029 N N   . PHE A 1 339 ? 110.843 141.011 121.335 1.00 34.62  ? 370 PHE A N   1 
ATOM   2030 C CA  . PHE A 1 339 ? 109.983 140.688 120.205 1.00 35.36  ? 370 PHE A CA  1 
ATOM   2031 C C   . PHE A 1 339 ? 110.088 141.739 119.108 1.00 35.05  ? 370 PHE A C   1 
ATOM   2032 O O   . PHE A 1 339 ? 110.019 141.404 117.925 1.00 37.29  ? 370 PHE A O   1 
ATOM   2033 C CB  . PHE A 1 339 ? 108.541 140.533 120.678 1.00 35.59  ? 370 PHE A CB  1 
ATOM   2034 C CG  . PHE A 1 339 ? 107.574 140.193 119.589 1.00 34.56  ? 370 PHE A CG  1 
ATOM   2035 C CD1 . PHE A 1 339 ? 107.811 139.114 118.738 1.00 35.94  ? 370 PHE A CD1 1 
ATOM   2036 C CD2 . PHE A 1 339 ? 106.413 140.945 119.431 1.00 34.84  ? 370 PHE A CD2 1 
ATOM   2037 C CE1 . PHE A 1 339 ? 106.905 138.799 117.733 1.00 37.42  ? 370 PHE A CE1 1 
ATOM   2038 C CE2 . PHE A 1 339 ? 105.501 140.643 118.430 1.00 35.04  ? 370 PHE A CE2 1 
ATOM   2039 C CZ  . PHE A 1 339 ? 105.749 139.572 117.583 1.00 35.08  ? 370 PHE A CZ  1 
ATOM   2040 N N   . ALA A 1 340 ? 110.308 143.008 119.468 1.00 32.00  ? 371 ALA A N   1 
ATOM   2041 C CA  . ALA A 1 340 ? 110.369 144.055 118.447 1.00 29.35  ? 371 ALA A CA  1 
ATOM   2042 C C   . ALA A 1 340 ? 111.746 144.143 117.805 1.00 34.51  ? 371 ALA A C   1 
ATOM   2043 O O   . ALA A 1 340 ? 111.935 144.881 116.836 1.00 37.04  ? 371 ALA A O   1 
ATOM   2044 C CB  . ALA A 1 340 ? 109.982 145.409 119.031 1.00 28.89  ? 371 ALA A CB  1 
ATOM   2045 N N   . GLY A 1 341 ? 112.728 143.416 118.335 1.00 36.85  ? 372 GLY A N   1 
ATOM   2046 C CA  . GLY A 1 341 ? 113.991 143.287 117.630 1.00 39.02  ? 372 GLY A CA  1 
ATOM   2047 C C   . GLY A 1 341 ? 113.896 142.361 116.433 1.00 41.57  ? 372 GLY A C   1 
ATOM   2048 O O   . GLY A 1 341 ? 114.679 142.468 115.489 1.00 42.99  ? 372 GLY A O   1 
ATOM   2049 N N   . SER A 1 342 ? 112.932 141.435 116.456 1.00 38.95  ? 373 SER A N   1 
ATOM   2050 C CA  . SER A 1 342 ? 112.815 140.463 115.375 1.00 37.78  ? 373 SER A CA  1 
ATOM   2051 C C   . SER A 1 342 ? 111.781 140.882 114.339 1.00 37.26  ? 373 SER A C   1 
ATOM   2052 O O   . SER A 1 342 ? 111.837 140.434 113.190 1.00 42.08  ? 373 SER A O   1 
ATOM   2053 C CB  . SER A 1 342 ? 112.470 139.091 115.942 1.00 39.35  ? 373 SER A CB  1 
ATOM   2054 O OG  . SER A 1 342 ? 113.626 138.468 116.460 1.00 44.35  ? 373 SER A OG  1 
ATOM   2055 N N   . ILE A 1 343 ? 110.812 141.710 114.731 1.00 36.21  ? 374 ILE A N   1 
ATOM   2056 C CA  . ILE A 1 343 ? 109.790 142.168 113.792 1.00 38.79  ? 374 ILE A CA  1 
ATOM   2057 C C   . ILE A 1 343 ? 110.356 143.224 112.843 1.00 40.99  ? 374 ILE A C   1 
ATOM   2058 O O   . ILE A 1 343 ? 110.062 143.211 111.642 1.00 47.01  ? 374 ILE A O   1 
ATOM   2059 C CB  . ILE A 1 343 ? 108.545 142.640 114.575 1.00 37.25  ? 374 ILE A CB  1 
ATOM   2060 C CG1 . ILE A 1 343 ? 107.935 141.454 115.317 1.00 39.12  ? 374 ILE A CG1 1 
ATOM   2061 C CG2 . ILE A 1 343 ? 107.463 143.245 113.707 1.00 35.92  ? 374 ILE A CG2 1 
ATOM   2062 C CD1 . ILE A 1 343 ? 107.476 140.311 114.406 1.00 39.14  ? 374 ILE A CD1 1 
ATOM   2063 N N   . ILE A 1 344 ? 111.251 144.088 113.336 1.00 37.90  ? 375 ILE A N   1 
ATOM   2064 C CA  . ILE A 1 344 ? 111.899 145.087 112.482 1.00 40.10  ? 375 ILE A CA  1 
ATOM   2065 C C   . ILE A 1 344 ? 112.952 144.422 111.579 1.00 43.44  ? 375 ILE A C   1 
ATOM   2066 O O   . ILE A 1 344 ? 113.204 144.879 110.459 1.00 45.44  ? 375 ILE A O   1 
ATOM   2067 C CB  . ILE A 1 344 ? 112.452 146.224 113.378 1.00 41.40  ? 375 ILE A CB  1 
ATOM   2068 C CG1 . ILE A 1 344 ? 111.302 146.840 114.177 1.00 40.31  ? 375 ILE A CG1 1 
ATOM   2069 C CG2 . ILE A 1 344 ? 113.050 147.399 112.587 1.00 43.87  ? 375 ILE A CG2 1 
ATOM   2070 C CD1 . ILE A 1 344 ? 111.725 147.855 115.239 1.00 39.72  ? 375 ILE A CD1 1 
ATOM   2071 N N   . ASP A 1 345 ? 113.474 143.259 111.982 1.00 43.80  ? 376 ASP A N   1 
ATOM   2072 C CA  . ASP A 1 345 ? 114.242 142.429 111.052 1.00 44.10  ? 376 ASP A CA  1 
ATOM   2073 C C   . ASP A 1 345 ? 113.343 141.717 110.041 1.00 45.18  ? 376 ASP A C   1 
ATOM   2074 O O   . ASP A 1 345 ? 113.808 141.297 108.977 1.00 47.08  ? 376 ASP A O   1 
ATOM   2075 C CB  . ASP A 1 345 ? 115.076 141.410 111.821 1.00 42.57  ? 376 ASP A CB  1 
ATOM   2076 C CG  . ASP A 1 345 ? 116.143 142.055 112.661 1.00 43.77  ? 376 ASP A CG  1 
ATOM   2077 O OD1 . ASP A 1 345 ? 116.441 143.240 112.417 1.00 45.23  ? 376 ASP A OD1 1 
ATOM   2078 O OD2 . ASP A 1 345 ? 116.679 141.381 113.563 1.00 44.33  ? 376 ASP A OD2 1 
ATOM   2079 N N   . LEU A 1 346 ? 112.056 141.558 110.358 1.00 43.79  ? 377 LEU A N   1 
ATOM   2080 C CA  . LEU A 1 346 ? 111.156 140.852 109.452 1.00 40.18  ? 377 LEU A CA  1 
ATOM   2081 C C   . LEU A 1 346 ? 110.372 141.812 108.565 1.00 42.83  ? 377 LEU A C   1 
ATOM   2082 O O   . LEU A 1 346 ? 110.111 141.500 107.400 1.00 50.05  ? 377 LEU A O   1 
ATOM   2083 C CB  . LEU A 1 346 ? 110.206 139.966 110.252 1.00 42.76  ? 377 LEU A CB  1 
ATOM   2084 C CG  . LEU A 1 346 ? 109.307 138.961 109.531 1.00 50.98  ? 377 LEU A CG  1 
ATOM   2085 C CD1 . LEU A 1 346 ? 110.027 138.217 108.420 1.00 49.98  ? 377 LEU A CD1 1 
ATOM   2086 C CD2 . LEU A 1 346 ? 108.765 137.980 110.541 1.00 53.82  ? 377 LEU A CD2 1 
ATOM   2087 N N   . MET A 1 347 ? 109.971 142.974 109.089 1.00 43.01  ? 378 MET A N   1 
ATOM   2088 C CA  . MET A 1 347 ? 109.178 143.891 108.272 1.00 45.60  ? 378 MET A CA  1 
ATOM   2089 C C   . MET A 1 347 ? 110.056 144.732 107.352 1.00 49.31  ? 378 MET A C   1 
ATOM   2090 O O   . MET A 1 347 ? 109.550 145.351 106.410 1.00 51.13  ? 378 MET A O   1 
ATOM   2091 C CB  . MET A 1 347 ? 108.310 144.795 109.146 1.00 47.10  ? 378 MET A CB  1 
ATOM   2092 C CG  . MET A 1 347 ? 107.289 144.079 110.019 1.00 48.13  ? 378 MET A CG  1 
ATOM   2093 S SD  . MET A 1 347 ? 105.744 143.607 109.233 1.00 58.71  ? 378 MET A SD  1 
ATOM   2094 C CE  . MET A 1 347 ? 105.518 141.972 109.929 1.00 51.18  ? 378 MET A CE  1 
ATOM   2095 N N   . ASN A 1 348 ? 111.367 144.789 107.610 1.00 47.87  ? 379 ASN A N   1 
ATOM   2096 C CA  . ASN A 1 348 ? 112.267 145.408 106.640 1.00 48.64  ? 379 ASN A CA  1 
ATOM   2097 C C   . ASN A 1 348 ? 112.660 144.414 105.559 1.00 50.77  ? 379 ASN A C   1 
ATOM   2098 O O   . ASN A 1 348 ? 113.094 144.810 104.471 1.00 55.13  ? 379 ASN A O   1 
ATOM   2099 C CB  . ASN A 1 348 ? 113.511 145.962 107.322 1.00 48.16  ? 379 ASN A CB  1 
ATOM   2100 C CG  . ASN A 1 348 ? 113.243 147.258 108.043 1.00 53.03  ? 379 ASN A CG  1 
ATOM   2101 O OD1 . ASN A 1 348 ? 112.276 147.956 107.743 1.00 55.39  ? 379 ASN A OD1 1 
ATOM   2102 N ND2 . ASN A 1 348 ? 114.096 147.589 109.005 1.00 54.92  ? 379 ASN A ND2 1 
ATOM   2103 N N   . TRP A 1 349 ? 112.549 143.119 105.857 1.00 46.89  ? 380 TRP A N   1 
ATOM   2104 C CA  . TRP A 1 349 ? 112.622 142.112 104.808 1.00 48.78  ? 380 TRP A CA  1 
ATOM   2105 C C   . TRP A 1 349 ? 111.390 142.173 103.918 1.00 48.67  ? 380 TRP A C   1 
ATOM   2106 O O   . TRP A 1 349 ? 111.482 141.957 102.705 1.00 54.56  ? 380 TRP A O   1 
ATOM   2107 C CB  . TRP A 1 349 ? 112.776 140.721 105.429 1.00 48.36  ? 380 TRP A CB  1 
ATOM   2108 C CG  . TRP A 1 349 ? 112.750 139.585 104.443 1.00 51.10  ? 380 TRP A CG  1 
ATOM   2109 C CD1 . TRP A 1 349 ? 113.809 139.068 103.761 1.00 54.91  ? 380 TRP A CD1 1 
ATOM   2110 C CD2 . TRP A 1 349 ? 111.608 138.818 104.050 1.00 51.55  ? 380 TRP A CD2 1 
ATOM   2111 N NE1 . TRP A 1 349 ? 113.397 138.036 102.956 1.00 56.46  ? 380 TRP A NE1 1 
ATOM   2112 C CE2 . TRP A 1 349 ? 112.047 137.867 103.111 1.00 53.76  ? 380 TRP A CE2 1 
ATOM   2113 C CE3 . TRP A 1 349 ? 110.249 138.865 104.382 1.00 52.15  ? 380 TRP A CE3 1 
ATOM   2114 C CZ2 . TRP A 1 349 ? 111.179 136.957 102.510 1.00 51.38  ? 380 TRP A CZ2 1 
ATOM   2115 C CZ3 . TRP A 1 349 ? 109.387 137.958 103.788 1.00 55.45  ? 380 TRP A CZ3 1 
ATOM   2116 C CH2 . TRP A 1 349 ? 109.857 137.014 102.863 1.00 51.32  ? 380 TRP A CH2 1 
ATOM   2117 N N   . LEU A 1 350 ? 110.228 142.461 104.510 1.00 45.16  ? 381 LEU A N   1 
ATOM   2118 C CA  . LEU A 1 350 ? 108.962 142.397 103.787 1.00 45.47  ? 381 LEU A CA  1 
ATOM   2119 C C   . LEU A 1 350 ? 108.784 143.589 102.858 1.00 46.80  ? 381 LEU A C   1 
ATOM   2120 O O   . LEU A 1 350 ? 108.019 143.517 101.894 1.00 55.28  ? 381 LEU A O   1 
ATOM   2121 C CB  . LEU A 1 350 ? 107.803 142.316 104.782 1.00 47.55  ? 381 LEU A CB  1 
ATOM   2122 C CG  . LEU A 1 350 ? 106.421 141.828 104.340 1.00 45.22  ? 381 LEU A CG  1 
ATOM   2123 C CD1 . LEU A 1 350 ? 106.522 140.568 103.492 1.00 43.28  ? 381 LEU A CD1 1 
ATOM   2124 C CD2 . LEU A 1 350 ? 105.528 141.607 105.546 1.00 47.69  ? 381 LEU A CD2 1 
ATOM   2125 N N   . ARG A 1 351 ? 109.480 144.688 103.126 1.00 43.71  ? 382 ARG A N   1 
ATOM   2126 C CA  . ARG A 1 351 ? 109.425 145.833 102.227 1.00 48.68  ? 382 ARG A CA  1 
ATOM   2127 C C   . ARG A 1 351 ? 110.238 145.569 100.968 1.00 53.73  ? 382 ARG A C   1 
ATOM   2128 O O   . ARG A 1 351 ? 109.900 146.051 99.882  1.00 59.69  ? 382 ARG A O   1 
ATOM   2129 C CB  . ARG A 1 351 ? 109.931 147.071 102.956 1.00 52.87  ? 382 ARG A CB  1 
ATOM   2130 C CG  . ARG A 1 351 ? 109.541 148.408 102.358 1.00 53.00  ? 382 ARG A CG  1 
ATOM   2131 C CD  . ARG A 1 351 ? 110.535 149.492 102.766 1.00 51.62  ? 382 ARG A CD  1 
ATOM   2132 N NE  . ARG A 1 351 ? 110.424 149.880 104.169 1.00 53.76  ? 382 ARG A NE  1 
ATOM   2133 C CZ  . ARG A 1 351 ? 111.285 149.536 105.119 1.00 53.04  ? 382 ARG A CZ  1 
ATOM   2134 N NH1 . ARG A 1 351 ? 112.320 148.754 104.862 1.00 48.01  ? 382 ARG A NH1 1 
ATOM   2135 N NH2 . ARG A 1 351 ? 111.089 149.970 106.360 1.00 56.20  ? 382 ARG A NH2 1 
ATOM   2136 N N   . GLY A 1 352 ? 111.315 144.795 101.097 1.00 53.24  ? 383 GLY A N   1 
ATOM   2137 C CA  . GLY A 1 352 ? 112.067 144.396 99.920  1.00 55.68  ? 383 GLY A CA  1 
ATOM   2138 C C   . GLY A 1 352 ? 111.390 143.274 99.158  1.00 55.40  ? 383 GLY A C   1 
ATOM   2139 O O   . GLY A 1 352 ? 111.515 143.178 97.935  1.00 57.40  ? 383 GLY A O   1 
ATOM   2140 N N   . SER A 1 353 ? 110.647 142.422 99.868  1.00 54.93  ? 384 SER A N   1 
ATOM   2141 C CA  . SER A 1 353 ? 109.972 141.302 99.220  1.00 52.93  ? 384 SER A CA  1 
ATOM   2142 C C   . SER A 1 353 ? 108.671 141.744 98.563  1.00 54.58  ? 384 SER A C   1 
ATOM   2143 O O   . SER A 1 353 ? 108.101 141.012 97.748  1.00 55.54  ? 384 SER A O   1 
ATOM   2144 C CB  . SER A 1 353 ? 109.713 140.190 100.234 1.00 49.26  ? 384 SER A CB  1 
ATOM   2145 O OG  . SER A 1 353 ? 109.418 138.974 99.583  1.00 48.13  ? 384 SER A OG  1 
ATOM   2146 N N   . LEU A 1 354 ? 108.169 142.925 98.929  1.00 55.97  ? 385 LEU A N   1 
ATOM   2147 C CA  . LEU A 1 354 ? 107.050 143.508 98.199  1.00 57.81  ? 385 LEU A CA  1 
ATOM   2148 C C   . LEU A 1 354 ? 107.536 144.500 97.152  1.00 60.68  ? 385 LEU A C   1 
ATOM   2149 O O   . LEU A 1 354 ? 106.736 145.038 96.382  1.00 65.93  ? 385 LEU A O   1 
ATOM   2150 C CB  . LEU A 1 354 ? 106.084 144.192 99.163  1.00 59.05  ? 385 LEU A CB  1 
ATOM   2151 C CG  . LEU A 1 354 ? 105.202 143.329 100.062 1.00 58.90  ? 385 LEU A CG  1 
ATOM   2152 C CD1 . LEU A 1 354 ? 104.658 144.189 101.183 1.00 55.52  ? 385 LEU A CD1 1 
ATOM   2153 C CD2 . LEU A 1 354 ? 104.085 142.702 99.280  1.00 62.20  ? 385 LEU A CD2 1 
ATOM   2154 N N   . SER A 1 355 ? 108.839 144.774 97.116  1.00 57.80  ? 386 SER A N   1 
ATOM   2155 C CA  . SER A 1 355 ? 109.356 145.701 96.115  1.00 57.80  ? 386 SER A CA  1 
ATOM   2156 C C   . SER A 1 355 ? 109.576 144.997 94.785  1.00 55.39  ? 386 SER A C   1 
ATOM   2157 O O   . SER A 1 355 ? 109.215 145.517 93.723  1.00 52.51  ? 386 SER A O   1 
ATOM   2158 C CB  . SER A 1 355 ? 110.652 146.341 96.609  1.00 60.30  ? 386 SER A CB  1 
ATOM   2159 O OG  . SER A 1 355 ? 111.168 147.251 95.653  1.00 68.80  ? 386 SER A OG  1 
ATOM   2160 N N   . LYS A 1 356 ? 110.164 143.802 94.826  1.00 56.38  ? 387 LYS A N   1 
ATOM   2161 C CA  . LYS A 1 356 ? 110.491 143.096 93.593  1.00 61.08  ? 387 LYS A CA  1 
ATOM   2162 C C   . LYS A 1 356 ? 109.309 142.280 93.080  1.00 62.38  ? 387 LYS A C   1 
ATOM   2163 O O   . LYS A 1 356 ? 109.258 141.935 91.894  1.00 62.85  ? 387 LYS A O   1 
ATOM   2164 C CB  . LYS A 1 356 ? 111.711 142.202 93.817  1.00 61.57  ? 387 LYS A CB  1 
ATOM   2165 C CG  . LYS A 1 356 ? 111.629 141.350 95.072  1.00 58.44  ? 387 LYS A CG  1 
ATOM   2166 C CD  . LYS A 1 356 ? 112.969 140.721 95.414  1.00 57.89  ? 387 LYS A CD  1 
ATOM   2167 C CE  . LYS A 1 356 ? 112.880 139.923 96.704  1.00 60.35  ? 387 LYS A CE  1 
ATOM   2168 N NZ  . LYS A 1 356 ? 114.217 139.533 97.220  1.00 63.15  ? 387 LYS A NZ  1 
ATOM   2169 N N   . HIS A 1 357 ? 108.350 141.959 93.952  1.00 60.73  ? 388 HIS A N   1 
ATOM   2170 C CA  . HIS A 1 357 ? 107.232 141.094 93.597  1.00 58.64  ? 388 HIS A CA  1 
ATOM   2171 C C   . HIS A 1 357 ? 105.932 141.857 93.378  1.00 57.60  ? 388 HIS A C   1 
ATOM   2172 O O   . HIS A 1 357 ? 104.998 141.311 92.784  1.00 59.88  ? 388 HIS A O   1 
ATOM   2173 C CB  . HIS A 1 357 ? 107.021 140.032 94.674  1.00 55.83  ? 388 HIS A CB  1 
ATOM   2174 C CG  . HIS A 1 357 ? 108.151 139.064 94.800  1.00 53.46  ? 388 HIS A CG  1 
ATOM   2175 N ND1 . HIS A 1 357 ? 108.876 138.918 95.961  1.00 55.82  ? 388 HIS A ND1 1 
ATOM   2176 C CD2 . HIS A 1 357 ? 108.680 138.191 93.913  1.00 53.40  ? 388 HIS A CD2 1 
ATOM   2177 C CE1 . HIS A 1 357 ? 109.805 137.997 95.784  1.00 55.22  ? 388 HIS A CE1 1 
ATOM   2178 N NE2 . HIS A 1 357 ? 109.708 137.540 94.549  1.00 56.43  ? 388 HIS A NE2 1 
ATOM   2179 N N   . CYS A 1 358 ? 105.851 143.105 93.820  1.00 56.63  ? 389 CYS A N   1 
ATOM   2180 C CA  . CYS A 1 358 ? 104.573 143.798 93.805  1.00 58.96  ? 389 CYS A CA  1 
ATOM   2181 C C   . CYS A 1 358 ? 104.785 145.238 93.362  1.00 62.97  ? 389 CYS A C   1 
ATOM   2182 O O   . CYS A 1 358 ? 105.873 145.800 93.492  1.00 67.39  ? 389 CYS A O   1 
ATOM   2183 C CB  . CYS A 1 358 ? 103.907 143.741 95.179  1.00 65.12  ? 389 CYS A CB  1 
ATOM   2184 S SG  . CYS A 1 358 ? 102.315 144.587 95.280  1.00 93.02  ? 389 CYS A SG  1 
ATOM   2185 N N   . LYS A 1 359 ? 103.716 145.831 92.848  1.00 61.13  ? 390 LYS A N   1 
ATOM   2186 C CA  . LYS A 1 359 ? 103.747 147.172 92.290  1.00 59.75  ? 390 LYS A CA  1 
ATOM   2187 C C   . LYS A 1 359 ? 103.051 148.125 93.247  1.00 66.93  ? 390 LYS A C   1 
ATOM   2188 O O   . LYS A 1 359 ? 102.146 147.721 93.983  1.00 69.78  ? 390 LYS A O   1 
ATOM   2189 C CB  . LYS A 1 359 ? 103.071 147.203 90.921  1.00 58.53  ? 390 LYS A CB  1 
ATOM   2190 C CG  . LYS A 1 359 ? 103.554 146.115 89.991  1.00 60.42  ? 390 LYS A CG  1 
ATOM   2191 C CD  . LYS A 1 359 ? 102.540 145.828 88.904  1.00 63.04  ? 390 LYS A CD  1 
ATOM   2192 C CE  . LYS A 1 359 ? 102.887 144.545 88.164  1.00 64.54  ? 390 LYS A CE  1 
ATOM   2193 N NZ  . LYS A 1 359 ? 101.804 144.128 87.230  1.00 67.85  ? 390 LYS A NZ  1 
ATOM   2194 N N   . ARG A 1 360 ? 103.476 149.383 93.235  1.00 74.11  ? 391 ARG A N   1 
ATOM   2195 C CA  . ARG A 1 360 ? 102.926 150.391 94.131  1.00 75.78  ? 391 ARG A CA  1 
ATOM   2196 C C   . ARG A 1 360 ? 101.662 151.007 93.544  1.00 71.76  ? 391 ARG A C   1 
ATOM   2197 O O   . ARG A 1 360 ? 101.548 151.170 92.329  1.00 67.50  ? 391 ARG A O   1 
ATOM   2198 C CB  . ARG A 1 360 ? 103.966 151.477 94.408  1.00 74.83  ? 391 ARG A CB  1 
ATOM   2199 C CG  . ARG A 1 360 ? 105.332 150.938 94.790  1.00 74.64  ? 391 ARG A CG  1 
ATOM   2200 C CD  . ARG A 1 360 ? 106.269 152.047 95.219  1.00 83.95  ? 391 ARG A CD  1 
ATOM   2201 N NE  . ARG A 1 360 ? 107.634 151.565 95.394  1.00 93.96  ? 391 ARG A NE  1 
ATOM   2202 C CZ  . ARG A 1 360 ? 108.669 152.338 95.696  1.00 95.40  ? 391 ARG A CZ  1 
ATOM   2203 N NH1 . ARG A 1 360 ? 108.532 153.644 95.860  1.00 96.07  ? 391 ARG A NH1 1 
ATOM   2204 N NH2 . ARG A 1 360 ? 109.872 151.788 95.834  1.00 92.29  ? 391 ARG A NH2 1 
ATOM   2205 N N   . ASP A 1 365 ? 102.144 155.469 96.483  1.00 87.60  ? 396 ASP A N   1 
ATOM   2206 C CA  . ASP A 1 365 ? 103.281 154.558 96.532  1.00 90.99  ? 396 ASP A CA  1 
ATOM   2207 C C   . ASP A 1 365 ? 103.047 153.469 97.573  1.00 86.57  ? 396 ASP A C   1 
ATOM   2208 O O   . ASP A 1 365 ? 103.986 152.970 98.194  1.00 86.61  ? 396 ASP A O   1 
ATOM   2209 C CB  . ASP A 1 365 ? 104.572 155.320 96.839  1.00 93.89  ? 396 ASP A CB  1 
ATOM   2210 C CG  . ASP A 1 365 ? 105.098 156.089 95.640  1.00 92.64  ? 396 ASP A CG  1 
ATOM   2211 O OD1 . ASP A 1 365 ? 104.463 156.035 94.565  1.00 93.49  ? 396 ASP A OD1 1 
ATOM   2212 O OD2 . ASP A 1 365 ? 106.150 156.749 95.774  1.00 87.23  ? 396 ASP A OD2 1 
ATOM   2213 N N   . LEU A 1 366 ? 101.783 153.102 97.748  1.00 82.24  ? 397 LEU A N   1 
ATOM   2214 C CA  . LEU A 1 366 ? 101.354 152.152 98.764  1.00 77.51  ? 397 LEU A CA  1 
ATOM   2215 C C   . LEU A 1 366 ? 101.197 150.791 98.100  1.00 76.04  ? 397 LEU A C   1 
ATOM   2216 O O   . LEU A 1 366 ? 100.595 150.695 97.026  1.00 76.88  ? 397 LEU A O   1 
ATOM   2217 C CB  . LEU A 1 366 ? 100.039 152.615 99.388  1.00 77.96  ? 397 LEU A CB  1 
ATOM   2218 C CG  . LEU A 1 366 ? 99.740  152.324 100.855 1.00 76.74  ? 397 LEU A CG  1 
ATOM   2219 C CD1 . LEU A 1 366 ? 100.832 152.877 101.742 1.00 75.63  ? 397 LEU A CD1 1 
ATOM   2220 C CD2 . LEU A 1 366 ? 98.394  152.913 101.244 1.00 71.90  ? 397 LEU A CD2 1 
ATOM   2221 N N   . TYR A 1 367 ? 101.745 149.748 98.725  1.00 75.05  ? 398 TYR A N   1 
ATOM   2222 C CA  . TYR A 1 367 ? 101.673 148.416 98.135  1.00 73.64  ? 398 TYR A CA  1 
ATOM   2223 C C   . TYR A 1 367 ? 100.293 147.809 98.346  1.00 75.01  ? 398 TYR A C   1 
ATOM   2224 O O   . TYR A 1 367 ? 100.001 147.235 99.398  1.00 76.17  ? 398 TYR A O   1 
ATOM   2225 C CB  . TYR A 1 367 ? 102.731 147.492 98.739  1.00 70.36  ? 398 TYR A CB  1 
ATOM   2226 C CG  . TYR A 1 367 ? 104.158 147.929 98.515  1.00 72.04  ? 398 TYR A CG  1 
ATOM   2227 C CD1 . TYR A 1 367 ? 104.881 148.549 99.537  1.00 72.42  ? 398 TYR A CD1 1 
ATOM   2228 C CD2 . TYR A 1 367 ? 104.777 147.742 97.276  1.00 71.28  ? 398 TYR A CD2 1 
ATOM   2229 C CE1 . TYR A 1 367 ? 106.200 148.957 99.337  1.00 71.05  ? 398 TYR A CE1 1 
ATOM   2230 C CE2 . TYR A 1 367 ? 106.094 148.154 97.062  1.00 66.37  ? 398 TYR A CE2 1 
ATOM   2231 C CZ  . TYR A 1 367 ? 106.791 148.756 98.097  1.00 67.96  ? 398 TYR A CZ  1 
ATOM   2232 O OH  . TYR A 1 367 ? 108.088 149.162 97.893  1.00 69.96  ? 398 TYR A OH  1 
ATOM   2233 N N   . VAL A 1 368 ? 99.449  147.914 97.325  1.00 73.87  ? 399 VAL A N   1 
ATOM   2234 C CA  . VAL A 1 368 ? 98.078  147.428 97.378  1.00 74.04  ? 399 VAL A CA  1 
ATOM   2235 C C   . VAL A 1 368 ? 98.116  145.932 97.112  1.00 77.55  ? 399 VAL A C   1 
ATOM   2236 O O   . VAL A 1 368 ? 98.728  145.493 96.133  1.00 79.71  ? 399 VAL A O   1 
ATOM   2237 C CB  . VAL A 1 368 ? 97.183  148.151 96.347  1.00 73.06  ? 399 VAL A CB  1 
ATOM   2238 C CG1 . VAL A 1 368 ? 95.723  147.764 96.511  1.00 73.18  ? 399 VAL A CG1 1 
ATOM   2239 C CG2 . VAL A 1 368 ? 97.349  149.652 96.461  1.00 77.14  ? 399 VAL A CG2 1 
ATOM   2240 N N   . LEU A 1 369 ? 97.439  145.153 97.972  1.00 75.34  ? 400 LEU A N   1 
ATOM   2241 C CA  . LEU A 1 369 ? 97.458  143.689 97.920  1.00 69.98  ? 400 LEU A CA  1 
ATOM   2242 C C   . LEU A 1 369 ? 96.727  143.116 96.707  1.00 72.67  ? 400 LEU A C   1 
ATOM   2243 O O   . LEU A 1 369 ? 96.986  141.969 96.329  1.00 75.50  ? 400 LEU A O   1 
ATOM   2244 C CB  . LEU A 1 369 ? 96.855  143.127 99.213  1.00 70.16  ? 400 LEU A CB  1 
ATOM   2245 C CG  . LEU A 1 369 ? 97.161  141.698 99.678  1.00 69.40  ? 400 LEU A CG  1 
ATOM   2246 C CD1 . LEU A 1 369 ? 98.600  141.552 100.106 1.00 69.50  ? 400 LEU A CD1 1 
ATOM   2247 C CD2 . LEU A 1 369 ? 96.235  141.294 100.808 1.00 63.72  ? 400 LEU A CD2 1 
ATOM   2248 N N   . GLU A 1 370 ? 95.847  143.893 96.068  1.00 74.53  ? 401 GLU A N   1 
ATOM   2249 C CA  . GLU A 1 370 ? 95.231  143.453 94.820  1.00 77.63  ? 401 GLU A CA  1 
ATOM   2250 C C   . GLU A 1 370 ? 96.215  143.506 93.653  1.00 75.12  ? 401 GLU A C   1 
ATOM   2251 O O   . GLU A 1 370 ? 96.041  142.795 92.658  1.00 74.79  ? 401 GLU A O   1 
ATOM   2252 C CB  . GLU A 1 370 ? 93.992  144.295 94.522  1.00 81.87  ? 401 GLU A CB  1 
ATOM   2253 C CG  . GLU A 1 370 ? 93.001  144.356 95.675  1.00 85.95  ? 401 GLU A CG  1 
ATOM   2254 C CD  . GLU A 1 370 ? 92.000  145.481 95.527  1.00 90.96  ? 401 GLU A CD  1 
ATOM   2255 O OE1 . GLU A 1 370 ? 92.138  146.281 94.578  1.00 94.75  ? 401 GLU A OE1 1 
ATOM   2256 O OE2 . GLU A 1 370 ? 91.072  145.564 96.358  1.00 88.14  ? 401 GLU A OE2 1 
ATOM   2257 N N   . SER A 1 371 ? 97.250  144.340 93.751  1.00 75.83  ? 402 SER A N   1 
ATOM   2258 C CA  . SER A 1 371 ? 98.318  144.375 92.762  1.00 75.69  ? 402 SER A CA  1 
ATOM   2259 C C   . SER A 1 371 ? 99.558  143.604 93.207  1.00 72.72  ? 402 SER A C   1 
ATOM   2260 O O   . SER A 1 371 ? 100.591 143.672 92.537  1.00 71.35  ? 402 SER A O   1 
ATOM   2261 C CB  . SER A 1 371 ? 98.689  145.821 92.433  1.00 79.60  ? 402 SER A CB  1 
ATOM   2262 O OG  . SER A 1 371 ? 99.593  145.878 91.344  1.00 82.17  ? 402 SER A OG  1 
ATOM   2263 N N   . CYS A 1 372 ? 99.480  142.875 94.317  1.00 76.01  ? 403 CYS A N   1 
ATOM   2264 C CA  . CYS A 1 372 ? 100.579 142.039 94.787  1.00 73.93  ? 403 CYS A CA  1 
ATOM   2265 C C   . CYS A 1 372 ? 100.314 140.590 94.408  1.00 79.47  ? 403 CYS A C   1 
ATOM   2266 O O   . CYS A 1 372 ? 99.216  140.073 94.642  1.00 85.15  ? 403 CYS A O   1 
ATOM   2267 C CB  . CYS A 1 372 ? 100.779 142.158 96.297  1.00 74.22  ? 403 CYS A CB  1 
ATOM   2268 S SG  . CYS A 1 372 ? 101.415 143.738 96.888  1.00 84.15  ? 403 CYS A SG  1 
ATOM   2269 N N   . PHE A 1 373 ? 101.317 139.942 93.826  1.00 74.66  ? 404 PHE A N   1 
ATOM   2270 C CA  . PHE A 1 373 ? 101.211 138.556 93.402  1.00 74.92  ? 404 PHE A CA  1 
ATOM   2271 C C   . PHE A 1 373 ? 102.488 137.821 93.768  1.00 73.89  ? 404 PHE A C   1 
ATOM   2272 O O   . PHE A 1 373 ? 103.585 138.330 93.512  1.00 77.38  ? 404 PHE A O   1 
ATOM   2273 C CB  . PHE A 1 373 ? 100.959 138.457 91.895  1.00 70.74  ? 404 PHE A CB  1 
ATOM   2274 N N   . ASN A 1 374 ? 102.315 136.638 94.378  1.00 74.08  ? 405 ASN A N   1 
ATOM   2275 C CA  . ASN A 1 374 ? 103.342 135.622 94.652  1.00 74.37  ? 405 ASN A CA  1 
ATOM   2276 C C   . ASN A 1 374 ? 104.474 136.121 95.544  1.00 69.43  ? 405 ASN A C   1 
ATOM   2277 O O   . ASN A 1 374 ? 105.623 135.726 95.366  1.00 73.87  ? 405 ASN A O   1 
ATOM   2278 C CB  . ASN A 1 374 ? 103.914 135.026 93.359  1.00 78.98  ? 405 ASN A CB  1 
ATOM   2279 C CG  . ASN A 1 374 ? 103.179 133.777 92.916  1.00 84.05  ? 405 ASN A CG  1 
ATOM   2280 O OD1 . ASN A 1 374 ? 102.347 133.240 93.646  1.00 89.04  ? 405 ASN A OD1 1 
ATOM   2281 N ND2 . ASN A 1 374 ? 103.487 133.306 91.714  1.00 80.31  ? 405 ASN A ND2 1 
ATOM   2282 N N   . PHE A 1 375 ? 104.170 136.983 96.507  1.00 66.58  ? 406 PHE A N   1 
ATOM   2283 C CA  . PHE A 1 375 ? 105.169 137.357 97.495  1.00 70.94  ? 406 PHE A CA  1 
ATOM   2284 C C   . PHE A 1 375 ? 105.176 136.342 98.637  1.00 71.46  ? 406 PHE A C   1 
ATOM   2285 O O   . PHE A 1 375 ? 104.392 135.385 98.640  1.00 78.59  ? 406 PHE A O   1 
ATOM   2286 C CB  . PHE A 1 375 ? 104.949 138.798 97.983  1.00 73.54  ? 406 PHE A CB  1 
ATOM   2287 C CG  . PHE A 1 375 ? 103.778 138.990 98.922  1.00 73.94  ? 406 PHE A CG  1 
ATOM   2288 C CD1 . PHE A 1 375 ? 102.475 139.082 98.424  1.00 72.14  ? 406 PHE A CD1 1 
ATOM   2289 C CD2 . PHE A 1 375 ? 103.990 139.148 100.295 1.00 74.63  ? 406 PHE A CD2 1 
ATOM   2290 C CE1 . PHE A 1 375 ? 101.399 139.279 99.279  1.00 71.62  ? 406 PHE A CE1 1 
ATOM   2291 C CE2 . PHE A 1 375 ? 102.919 139.342 101.163 1.00 74.01  ? 406 PHE A CE2 1 
ATOM   2292 C CZ  . PHE A 1 375 ? 101.623 139.410 100.650 1.00 72.37  ? 406 PHE A CZ  1 
ATOM   2293 N N   . LEU A 1 376 ? 106.067 136.598 99.615  1.00 66.28  ? 407 LEU A N   1 
ATOM   2294 C CA  . LEU A 1 376 ? 106.512 135.665 100.669 1.00 72.64  ? 407 LEU A CA  1 
ATOM   2295 C C   . LEU A 1 376 ? 106.965 134.324 100.095 1.00 81.14  ? 407 LEU A C   1 
ATOM   2296 O O   . LEU A 1 376 ? 106.454 133.271 100.481 1.00 83.60  ? 407 LEU A O   1 
ATOM   2297 C CB  . LEU A 1 376 ? 105.446 135.435 101.755 1.00 78.85  ? 407 LEU A CB  1 
ATOM   2298 C CG  . LEU A 1 376 ? 104.969 136.523 102.713 1.00 78.85  ? 407 LEU A CG  1 
ATOM   2299 C CD1 . LEU A 1 376 ? 103.593 136.158 103.232 1.00 65.55  ? 407 LEU A CD1 1 
ATOM   2300 C CD2 . LEU A 1 376 ? 105.932 136.677 103.869 1.00 79.43  ? 407 LEU A CD2 1 
ATOM   2301 N N   . ASN A 1 377 ? 107.903 134.344 99.148  1.00 84.79  ? 408 ASN A N   1 
ATOM   2302 C CA  . ASN A 1 377 ? 108.347 133.101 98.524  1.00 87.25  ? 408 ASN A CA  1 
ATOM   2303 C C   . ASN A 1 377 ? 109.390 132.374 99.361  1.00 88.13  ? 408 ASN A C   1 
ATOM   2304 O O   . ASN A 1 377 ? 109.192 131.214 99.734  1.00 87.22  ? 408 ASN A O   1 
ATOM   2305 C CB  . ASN A 1 377 ? 108.903 133.369 97.124  1.00 85.27  ? 408 ASN A CB  1 
ATOM   2306 C CG  . ASN A 1 377 ? 107.818 133.546 96.094  1.00 81.29  ? 408 ASN A CG  1 
ATOM   2307 O OD1 . ASN A 1 377 ? 106.802 132.855 96.123  1.00 77.64  ? 408 ASN A OD1 1 
ATOM   2308 N ND2 . ASN A 1 377 ? 108.031 134.463 95.161  1.00 80.94  ? 408 ASN A ND2 1 
ATOM   2309 N N   . PHE A 1 378 ? 110.500 133.037 99.666  1.00 87.98  ? 409 PHE A N   1 
ATOM   2310 C CA  . PHE A 1 378 ? 111.601 132.422 100.397 1.00 91.52  ? 409 PHE A CA  1 
ATOM   2311 C C   . PHE A 1 378 ? 111.599 133.044 101.786 1.00 88.96  ? 409 PHE A C   1 
ATOM   2312 O O   . PHE A 1 378 ? 112.365 133.969 102.063 1.00 89.18  ? 409 PHE A O   1 
ATOM   2313 C CB  . PHE A 1 378 ? 112.924 132.640 99.673  1.00 94.29  ? 409 PHE A CB  1 
ATOM   2314 C CG  . PHE A 1 378 ? 113.147 131.698 98.526  1.00 98.13  ? 409 PHE A CG  1 
ATOM   2315 C CD1 . PHE A 1 378 ? 113.594 130.394 98.757  1.00 98.54  ? 409 PHE A CD1 1 
ATOM   2316 C CD2 . PHE A 1 378 ? 112.898 132.113 97.215  1.00 97.81  ? 409 PHE A CD2 1 
ATOM   2317 C CE1 . PHE A 1 378 ? 113.796 129.512 97.693  1.00 99.10  ? 409 PHE A CE1 1 
ATOM   2318 C CE2 . PHE A 1 378 ? 113.095 131.242 96.142  1.00 98.32  ? 409 PHE A CE2 1 
ATOM   2319 C CZ  . PHE A 1 378 ? 113.545 129.941 96.385  1.00 98.67  ? 409 PHE A CZ  1 
ATOM   2320 N N   . ILE A 1 379 ? 110.764 132.495 102.669 1.00 87.63  ? 410 ILE A N   1 
ATOM   2321 C CA  . ILE A 1 379 ? 110.479 133.128 103.953 1.00 88.18  ? 410 ILE A CA  1 
ATOM   2322 C C   . ILE A 1 379 ? 111.594 132.864 104.965 1.00 86.58  ? 410 ILE A C   1 
ATOM   2323 O O   . ILE A 1 379 ? 111.730 133.609 105.943 1.00 88.19  ? 410 ILE A O   1 
ATOM   2324 C CB  . ILE A 1 379 ? 109.103 132.647 104.468 1.00 87.90  ? 410 ILE A CB  1 
ATOM   2325 C CG1 . ILE A 1 379 ? 108.114 132.536 103.309 1.00 89.10  ? 410 ILE A CG1 1 
ATOM   2326 C CG2 . ILE A 1 379 ? 108.449 133.675 105.390 1.00 78.50  ? 410 ILE A CG2 1 
ATOM   2327 C CD1 . ILE A 1 379 ? 106.834 131.792 103.636 1.00 83.48  ? 410 ILE A CD1 1 
ATOM   2328 N N   . GLU A 1 380 ? 112.453 131.874 104.717 1.00 86.16  ? 411 GLU A N   1 
ATOM   2329 C CA  . GLU A 1 380 ? 113.535 131.577 105.649 1.00 86.88  ? 411 GLU A CA  1 
ATOM   2330 C C   . GLU A 1 380 ? 114.765 132.456 105.443 1.00 89.95  ? 411 GLU A C   1 
ATOM   2331 O O   . GLU A 1 380 ? 115.738 132.309 106.189 1.00 92.43  ? 411 GLU A O   1 
ATOM   2332 C CB  . GLU A 1 380 ? 113.941 130.108 105.530 1.00 90.83  ? 411 GLU A CB  1 
ATOM   2333 C CG  . GLU A 1 380 ? 112.874 129.104 105.941 1.00 90.87  ? 411 GLU A CG  1 
ATOM   2334 C CD  . GLU A 1 380 ? 112.605 129.100 107.433 1.00 93.65  ? 411 GLU A CD  1 
ATOM   2335 O OE1 . GLU A 1 380 ? 113.557 129.315 108.213 1.00 95.64  ? 411 GLU A OE1 1 
ATOM   2336 O OE2 . GLU A 1 380 ? 111.444 128.867 107.828 1.00 90.25  ? 411 GLU A OE2 1 
ATOM   2337 N N   . ASP A 1 381 ? 114.754 133.364 104.460 1.00 92.52  ? 412 ASP A N   1 
ATOM   2338 C CA  . ASP A 1 381 ? 115.933 134.171 104.154 1.00 94.44  ? 412 ASP A CA  1 
ATOM   2339 C C   . ASP A 1 381 ? 116.158 135.333 105.114 1.00 90.76  ? 412 ASP A C   1 
ATOM   2340 O O   . ASP A 1 381 ? 117.206 135.979 105.019 1.00 88.50  ? 412 ASP A O   1 
ATOM   2341 C CB  . ASP A 1 381 ? 115.858 134.731 102.731 1.00 94.29  ? 412 ASP A CB  1 
ATOM   2342 C CG  . ASP A 1 381 ? 115.855 133.650 101.674 1.00 98.20  ? 412 ASP A CG  1 
ATOM   2343 O OD1 . ASP A 1 381 ? 115.855 132.454 102.032 1.00 97.12  ? 412 ASP A OD1 1 
ATOM   2344 O OD2 . ASP A 1 381 ? 115.887 134.005 100.477 1.00 101.40 ? 412 ASP A OD2 1 
ATOM   2345 N N   . TRP A 1 382 ? 115.221 135.632 106.021 1.00 85.68  ? 413 TRP A N   1 
ATOM   2346 C CA  . TRP A 1 382 ? 115.464 136.718 106.965 1.00 82.31  ? 413 TRP A CA  1 
ATOM   2347 C C   . TRP A 1 382 ? 116.239 136.222 108.182 1.00 85.84  ? 413 TRP A C   1 
ATOM   2348 O O   . TRP A 1 382 ? 116.718 137.027 108.987 1.00 87.56  ? 413 TRP A O   1 
ATOM   2349 C CB  . TRP A 1 382 ? 114.148 137.380 107.380 1.00 77.30  ? 413 TRP A CB  1 
ATOM   2350 C CG  . TRP A 1 382 ? 113.375 136.660 108.438 1.00 79.62  ? 413 TRP A CG  1 
ATOM   2351 C CD1 . TRP A 1 382 ? 112.531 135.616 108.260 1.00 80.37  ? 413 TRP A CD1 1 
ATOM   2352 C CD2 . TRP A 1 382 ? 113.339 136.971 109.838 1.00 82.13  ? 413 TRP A CD2 1 
ATOM   2353 N NE1 . TRP A 1 382 ? 111.988 135.233 109.457 1.00 77.09  ? 413 TRP A NE1 1 
ATOM   2354 C CE2 . TRP A 1 382 ? 112.466 136.050 110.445 1.00 77.66  ? 413 TRP A CE2 1 
ATOM   2355 C CE3 . TRP A 1 382 ? 113.972 137.931 110.638 1.00 83.99  ? 413 TRP A CE3 1 
ATOM   2356 C CZ2 . TRP A 1 382 ? 112.206 136.056 111.814 1.00 75.96  ? 413 TRP A CZ2 1 
ATOM   2357 C CZ3 . TRP A 1 382 ? 113.713 137.938 112.001 1.00 80.25  ? 413 TRP A CZ3 1 
ATOM   2358 C CH2 . TRP A 1 382 ? 112.837 137.004 112.572 1.00 74.36  ? 413 TRP A CH2 1 
ATOM   2359 N N   . ARG A 1 383 ? 116.377 134.902 108.332 1.00 87.58  ? 414 ARG A N   1 
ATOM   2360 C CA  . ARG A 1 383 ? 117.280 134.347 109.332 1.00 88.34  ? 414 ARG A CA  1 
ATOM   2361 C C   . ARG A 1 383 ? 118.740 134.457 108.910 1.00 89.32  ? 414 ARG A C   1 
ATOM   2362 O O   . ARG A 1 383 ? 119.627 134.401 109.770 1.00 86.81  ? 414 ARG A O   1 
ATOM   2363 C CB  . ARG A 1 383 ? 116.931 132.883 109.604 1.00 86.16  ? 414 ARG A CB  1 
ATOM   2364 C CG  . ARG A 1 383 ? 115.455 132.629 109.847 1.00 80.74  ? 414 ARG A CG  1 
ATOM   2365 C CD  . ARG A 1 383 ? 115.005 133.246 111.153 1.00 80.72  ? 414 ARG A CD  1 
ATOM   2366 N NE  . ARG A 1 383 ? 115.821 132.806 112.277 1.00 81.93  ? 414 ARG A NE  1 
ATOM   2367 C CZ  . ARG A 1 383 ? 115.842 133.400 113.461 1.00 80.43  ? 414 ARG A CZ  1 
ATOM   2368 N NH1 . ARG A 1 383 ? 115.111 134.475 113.707 1.00 78.73  ? 414 ARG A NH1 1 
ATOM   2369 N NH2 . ARG A 1 383 ? 116.616 132.905 114.422 1.00 79.32  ? 414 ARG A NH2 1 
ATOM   2370 N N   . THR A 1 384 ? 118.999 134.572 107.609 1.00 91.37  ? 415 THR A N   1 
ATOM   2371 C CA  . THR A 1 384 ? 120.325 134.854 107.079 1.00 92.35  ? 415 THR A CA  1 
ATOM   2372 C C   . THR A 1 384 ? 120.711 136.286 107.453 1.00 93.22  ? 415 THR A C   1 
ATOM   2373 O O   . THR A 1 384 ? 119.880 137.196 107.428 1.00 94.97  ? 415 THR A O   1 
ATOM   2374 C CB  . THR A 1 384 ? 120.307 134.639 105.555 1.00 95.29  ? 415 THR A CB  1 
ATOM   2375 O OG1 . THR A 1 384 ? 119.782 133.335 105.278 1.00 95.55  ? 415 THR A OG1 1 
ATOM   2376 C CG2 . THR A 1 384 ? 121.698 134.705 104.914 1.00 92.23  ? 415 THR A CG2 1 
ATOM   2377 N N   . SER A 1 385 ? 121.995 136.489 107.793 1.00 94.69  ? 416 SER A N   1 
ATOM   2378 C CA  . SER A 1 385 ? 122.451 137.705 108.468 1.00 95.75  ? 416 SER A CA  1 
ATOM   2379 C C   . SER A 1 385 ? 122.552 138.937 107.564 1.00 96.23  ? 416 SER A C   1 
ATOM   2380 O O   . SER A 1 385 ? 122.879 140.019 108.062 1.00 94.58  ? 416 SER A O   1 
ATOM   2381 C CB  . SER A 1 385 ? 123.808 137.449 109.124 1.00 93.78  ? 416 SER A CB  1 
ATOM   2382 O OG  . SER A 1 385 ? 124.280 138.608 109.787 1.00 91.85  ? 416 SER A OG  1 
ATOM   2383 N N   . GLU A 1 386 ? 122.285 138.814 106.259 1.00 96.83  ? 417 GLU A N   1 
ATOM   2384 C CA  . GLU A 1 386 ? 122.200 139.998 105.407 1.00 98.23  ? 417 GLU A CA  1 
ATOM   2385 C C   . GLU A 1 386 ? 120.885 140.749 105.616 1.00 99.59  ? 417 GLU A C   1 
ATOM   2386 O O   . GLU A 1 386 ? 120.783 141.935 105.282 1.00 98.81  ? 417 GLU A O   1 
ATOM   2387 C CB  . GLU A 1 386 ? 122.379 139.604 103.938 1.00 99.37  ? 417 GLU A CB  1 
ATOM   2388 C CG  . GLU A 1 386 ? 121.296 138.693 103.374 1.00 102.44 ? 417 GLU A CG  1 
ATOM   2389 C CD  . GLU A 1 386 ? 121.565 138.280 101.940 1.00 105.35 ? 417 GLU A CD  1 
ATOM   2390 O OE1 . GLU A 1 386 ? 122.613 138.680 101.391 1.00 104.15 ? 417 GLU A OE1 1 
ATOM   2391 O OE2 . GLU A 1 386 ? 120.728 137.555 101.361 1.00 104.55 ? 417 GLU A OE2 1 
ATOM   2392 N N   . TYR A 1 387 ? 119.865 140.081 106.167 1.00 99.10  ? 418 TYR A N   1 
ATOM   2393 C CA  . TYR A 1 387 ? 118.591 140.715 106.469 1.00 96.28  ? 418 TYR A CA  1 
ATOM   2394 C C   . TYR A 1 387 ? 118.312 140.861 107.958 1.00 94.69  ? 418 TYR A C   1 
ATOM   2395 O O   . TYR A 1 387 ? 117.419 141.632 108.326 1.00 95.07  ? 418 TYR A O   1 
ATOM   2396 C CB  . TYR A 1 387 ? 117.439 139.937 105.817 1.00 91.58  ? 418 TYR A CB  1 
ATOM   2397 C CG  . TYR A 1 387 ? 117.227 140.289 104.367 1.00 94.99  ? 418 TYR A CG  1 
ATOM   2398 C CD1 . TYR A 1 387 ? 116.781 141.567 104.004 1.00 96.43  ? 418 TYR A CD1 1 
ATOM   2399 C CD2 . TYR A 1 387 ? 117.473 139.352 103.359 1.00 96.57  ? 418 TYR A CD2 1 
ATOM   2400 C CE1 . TYR A 1 387 ? 116.583 141.906 102.666 1.00 99.51  ? 418 TYR A CE1 1 
ATOM   2401 C CE2 . TYR A 1 387 ? 117.279 139.677 102.014 1.00 99.45  ? 418 TYR A CE2 1 
ATOM   2402 C CZ  . TYR A 1 387 ? 116.834 140.955 101.683 1.00 101.00 ? 418 TYR A CZ  1 
ATOM   2403 O OH  . TYR A 1 387 ? 116.640 141.285 100.362 1.00 104.14 ? 418 TYR A OH  1 
ATOM   2404 N N   . ARG A 1 388 ? 119.041 140.158 108.820 1.00 94.78  ? 419 ARG A N   1 
ATOM   2405 C CA  . ARG A 1 388 ? 118.839 140.233 110.262 1.00 93.86  ? 419 ARG A CA  1 
ATOM   2406 C C   . ARG A 1 388 ? 119.930 141.108 110.867 1.00 93.77  ? 419 ARG A C   1 
ATOM   2407 O O   . ARG A 1 388 ? 121.110 140.745 110.846 1.00 93.69  ? 419 ARG A O   1 
ATOM   2408 C CB  . ARG A 1 388 ? 118.839 138.839 110.883 1.00 91.99  ? 419 ARG A CB  1 
ATOM   2409 C CG  . ARG A 1 388 ? 118.592 138.845 112.372 1.00 93.73  ? 419 ARG A CG  1 
ATOM   2410 C CD  . ARG A 1 388 ? 118.146 137.484 112.882 1.00 94.49  ? 419 ARG A CD  1 
ATOM   2411 N NE  . ARG A 1 388 ? 118.112 137.436 114.340 1.00 98.33  ? 419 ARG A NE  1 
ATOM   2412 C CZ  . ARG A 1 388 ? 117.091 137.837 115.087 1.00 94.64  ? 419 ARG A CZ  1 
ATOM   2413 N NH1 . ARG A 1 388 ? 115.981 138.314 114.547 1.00 89.65  ? 419 ARG A NH1 1 
ATOM   2414 N NH2 . ARG A 1 388 ? 117.186 137.756 116.411 1.00 96.31  ? 419 ARG A NH2 1 
ATOM   2415 N N   . GLN A 1 389 ? 119.533 142.256 111.412 1.00 92.70  ? 420 GLN A N   1 
ATOM   2416 C CA  . GLN A 1 389 ? 120.453 143.238 111.971 1.00 90.91  ? 420 GLN A CA  1 
ATOM   2417 C C   . GLN A 1 389 ? 120.146 143.438 113.447 1.00 88.44  ? 420 GLN A C   1 
ATOM   2418 O O   . GLN A 1 389 ? 119.019 143.195 113.888 1.00 86.27  ? 420 GLN A O   1 
ATOM   2419 C CB  . GLN A 1 389 ? 120.347 144.577 111.235 1.00 91.02  ? 420 GLN A CB  1 
ATOM   2420 C CG  . GLN A 1 389 ? 120.490 144.484 109.727 1.00 94.24  ? 420 GLN A CG  1 
ATOM   2421 C CD  . GLN A 1 389 ? 119.985 145.726 109.025 1.00 95.81  ? 420 GLN A CD  1 
ATOM   2422 O OE1 . GLN A 1 389 ? 119.463 146.641 109.661 1.00 94.76  ? 420 GLN A OE1 1 
ATOM   2423 N NE2 . GLN A 1 389 ? 120.138 145.766 107.707 1.00 94.27  ? 420 GLN A NE2 1 
ATOM   2424 N N   . ALA A 1 390 ? 121.146 143.867 114.210 1.00 87.79  ? 421 ALA A N   1 
ATOM   2425 C CA  . ALA A 1 390 ? 120.913 144.222 115.602 1.00 82.39  ? 421 ALA A CA  1 
ATOM   2426 C C   . ALA A 1 390 ? 120.485 145.681 115.707 1.00 80.25  ? 421 ALA A C   1 
ATOM   2427 O O   . ALA A 1 390 ? 121.077 146.564 115.081 1.00 77.09  ? 421 ALA A O   1 
ATOM   2428 C CB  . ALA A 1 390 ? 122.169 143.976 116.436 1.00 76.82  ? 421 ALA A CB  1 
ATOM   2429 N N   . HIS A 1 391 ? 119.448 145.931 116.505 1.00 79.58  ? 422 HIS A N   1 
ATOM   2430 C CA  . HIS A 1 391 ? 118.891 147.266 116.667 1.00 75.06  ? 422 HIS A CA  1 
ATOM   2431 C C   . HIS A 1 391 ? 119.110 147.763 118.086 1.00 72.20  ? 422 HIS A C   1 
ATOM   2432 O O   . HIS A 1 391 ? 118.978 147.009 119.054 1.00 72.20  ? 422 HIS A O   1 
ATOM   2433 C CB  . HIS A 1 391 ? 117.390 147.308 116.364 1.00 75.10  ? 422 HIS A CB  1 
ATOM   2434 C CG  . HIS A 1 391 ? 117.026 146.783 115.013 1.00 76.74  ? 422 HIS A CG  1 
ATOM   2435 N ND1 . HIS A 1 391 ? 116.998 147.579 113.890 1.00 75.61  ? 422 HIS A ND1 1 
ATOM   2436 C CD2 . HIS A 1 391 ? 116.662 145.545 114.608 1.00 77.75  ? 422 HIS A CD2 1 
ATOM   2437 C CE1 . HIS A 1 391 ? 116.640 146.851 112.847 1.00 76.66  ? 422 HIS A CE1 1 
ATOM   2438 N NE2 . HIS A 1 391 ? 116.431 145.613 113.257 1.00 80.57  ? 422 HIS A NE2 1 
ATOM   2439 N N   . ASP A 1 392 ? 119.439 149.046 118.195 1.00 69.57  ? 423 ASP A N   1 
ATOM   2440 C CA  . ASP A 1 392 ? 119.495 149.717 119.480 1.00 67.99  ? 423 ASP A CA  1 
ATOM   2441 C C   . ASP A 1 392 ? 118.082 149.946 120.003 1.00 67.44  ? 423 ASP A C   1 
ATOM   2442 O O   . ASP A 1 392 ? 117.116 149.993 119.240 1.00 69.65  ? 423 ASP A O   1 
ATOM   2443 C CB  . ASP A 1 392 ? 120.246 151.042 119.359 1.00 68.37  ? 423 ASP A CB  1 
ATOM   2444 C CG  . ASP A 1 392 ? 120.931 151.446 120.649 1.00 71.25  ? 423 ASP A CG  1 
ATOM   2445 O OD1 . ASP A 1 392 ? 121.050 150.594 121.554 1.00 70.61  ? 423 ASP A OD1 1 
ATOM   2446 O OD2 . ASP A 1 392 ? 121.350 152.618 120.757 1.00 69.55  ? 423 ASP A OD2 1 
ATOM   2447 N N   . THR A 1 393 ? 117.978 150.092 121.329 1.00 65.07  ? 424 THR A N   1 
ATOM   2448 C CA  . THR A 1 393 ? 116.683 150.215 122.000 1.00 60.82  ? 424 THR A CA  1 
ATOM   2449 C C   . THR A 1 393 ? 116.060 151.585 121.732 1.00 61.22  ? 424 THR A C   1 
ATOM   2450 O O   . THR A 1 393 ? 114.846 151.699 121.518 1.00 62.50  ? 424 THR A O   1 
ATOM   2451 C CB  . THR A 1 393 ? 116.894 149.922 123.497 1.00 62.46  ? 424 THR A CB  1 
ATOM   2452 O OG1 . THR A 1 393 ? 117.101 148.515 123.667 1.00 64.07  ? 424 THR A OG1 1 
ATOM   2453 C CG2 . THR A 1 393 ? 115.726 150.335 124.400 1.00 62.01  ? 424 THR A CG2 1 
ATOM   2454 N N   . ALA A 1 394 ? 116.900 152.609 121.568 1.00 61.76  ? 425 ALA A N   1 
ATOM   2455 C CA  . ALA A 1 394 ? 116.402 153.926 121.177 1.00 59.10  ? 425 ALA A CA  1 
ATOM   2456 C C   . ALA A 1 394 ? 116.106 154.001 119.683 1.00 59.42  ? 425 ALA A C   1 
ATOM   2457 O O   . ALA A 1 394 ? 115.460 154.949 119.225 1.00 58.16  ? 425 ALA A O   1 
ATOM   2458 C CB  . ALA A 1 394 ? 117.407 155.005 121.571 1.00 60.64  ? 425 ALA A CB  1 
ATOM   2459 N N   . GLU A 1 395 ? 116.595 153.034 118.901 1.00 63.17  ? 426 GLU A N   1 
ATOM   2460 C CA  . GLU A 1 395 ? 116.243 152.969 117.486 1.00 62.60  ? 426 GLU A CA  1 
ATOM   2461 C C   . GLU A 1 395 ? 114.927 152.224 117.284 1.00 57.93  ? 426 GLU A C   1 
ATOM   2462 O O   . GLU A 1 395 ? 114.195 152.500 116.327 1.00 60.58  ? 426 GLU A O   1 
ATOM   2463 C CB  . GLU A 1 395 ? 117.380 152.307 116.703 1.00 68.37  ? 426 GLU A CB  1 
ATOM   2464 C CG  . GLU A 1 395 ? 117.339 152.499 115.192 1.00 71.48  ? 426 GLU A CG  1 
ATOM   2465 C CD  . GLU A 1 395 ? 118.395 151.684 114.471 1.00 80.54  ? 426 GLU A CD  1 
ATOM   2466 O OE1 . GLU A 1 395 ? 119.169 150.976 115.149 1.00 78.22  ? 426 GLU A OE1 1 
ATOM   2467 O OE2 . GLU A 1 395 ? 118.455 151.759 113.226 1.00 84.88  ? 426 GLU A OE2 1 
ATOM   2468 N N   . ILE A 1 396 ? 114.618 151.274 118.177 1.00 55.59  ? 427 ILE A N   1 
ATOM   2469 C CA  . ILE A 1 396 ? 113.354 150.535 118.125 1.00 53.22  ? 427 ILE A CA  1 
ATOM   2470 C C   . ILE A 1 396 ? 112.189 151.445 118.507 1.00 55.12  ? 427 ILE A C   1 
ATOM   2471 O O   . ILE A 1 396 ? 111.159 151.483 117.823 1.00 60.35  ? 427 ILE A O   1 
ATOM   2472 C CB  . ILE A 1 396 ? 113.437 149.287 119.029 1.00 52.61  ? 427 ILE A CB  1 
ATOM   2473 C CG1 . ILE A 1 396 ? 114.370 148.249 118.422 1.00 53.69  ? 427 ILE A CG1 1 
ATOM   2474 C CG2 . ILE A 1 396 ? 112.086 148.628 119.256 1.00 51.29  ? 427 ILE A CG2 1 
ATOM   2475 C CD1 . ILE A 1 396 ? 114.697 147.105 119.353 1.00 53.79  ? 427 ILE A CD1 1 
ATOM   2476 N N   . LEU A 1 397 ? 112.376 152.254 119.554 1.00 53.66  ? 428 LEU A N   1 
ATOM   2477 C CA  . LEU A 1 397 ? 111.310 153.120 120.054 1.00 51.85  ? 428 LEU A CA  1 
ATOM   2478 C C   . LEU A 1 397 ? 111.085 154.328 119.151 1.00 53.04  ? 428 LEU A C   1 
ATOM   2479 O O   . LEU A 1 397 ? 110.007 154.929 119.171 1.00 55.75  ? 428 LEU A O   1 
ATOM   2480 C CB  . LEU A 1 397 ? 111.640 153.590 121.469 1.00 55.84  ? 428 LEU A CB  1 
ATOM   2481 C CG  . LEU A 1 397 ? 111.739 152.606 122.634 1.00 58.63  ? 428 LEU A CG  1 
ATOM   2482 C CD1 . LEU A 1 397 ? 111.618 153.364 123.937 1.00 58.86  ? 428 LEU A CD1 1 
ATOM   2483 C CD2 . LEU A 1 397 ? 110.693 151.520 122.561 1.00 64.22  ? 428 LEU A CD2 1 
ATOM   2484 N N   . SER A 1 398 ? 112.088 154.706 118.362 1.00 54.02  ? 429 SER A N   1 
ATOM   2485 C CA  . SER A 1 398 ? 111.909 155.817 117.436 1.00 54.41  ? 429 SER A CA  1 
ATOM   2486 C C   . SER A 1 398 ? 111.234 155.357 116.151 1.00 59.70  ? 429 SER A C   1 
ATOM   2487 O O   . SER A 1 398 ? 110.447 156.100 115.553 1.00 62.33  ? 429 SER A O   1 
ATOM   2488 C CB  . SER A 1 398 ? 113.256 156.473 117.136 1.00 56.99  ? 429 SER A CB  1 
ATOM   2489 O OG  . SER A 1 398 ? 114.106 155.595 116.419 1.00 60.61  ? 429 SER A OG  1 
ATOM   2490 N N   . LEU A 1 399 ? 111.542 154.134 115.705 1.00 57.57  ? 430 LEU A N   1 
ATOM   2491 C CA  . LEU A 1 399 ? 110.977 153.623 114.459 1.00 51.89  ? 430 LEU A CA  1 
ATOM   2492 C C   . LEU A 1 399 ? 109.531 153.192 114.623 1.00 55.98  ? 430 LEU A C   1 
ATOM   2493 O O   . LEU A 1 399 ? 108.718 153.410 113.719 1.00 64.39  ? 430 LEU A O   1 
ATOM   2494 C CB  . LEU A 1 399 ? 111.798 152.444 113.944 1.00 51.23  ? 430 LEU A CB  1 
ATOM   2495 C CG  . LEU A 1 399 ? 113.056 152.737 113.129 1.00 59.26  ? 430 LEU A CG  1 
ATOM   2496 C CD1 . LEU A 1 399 ? 113.652 151.436 112.624 1.00 64.13  ? 430 LEU A CD1 1 
ATOM   2497 C CD2 . LEU A 1 399 ? 112.755 153.678 111.972 1.00 53.71  ? 430 LEU A CD2 1 
ATOM   2498 N N   . LEU A 1 400 ? 109.185 152.603 115.766 1.00 54.62  ? 431 LEU A N   1 
ATOM   2499 C CA  . LEU A 1 400 ? 107.885 151.983 115.965 1.00 50.29  ? 431 LEU A CA  1 
ATOM   2500 C C   . LEU A 1 400 ? 106.840 152.933 116.518 1.00 49.05  ? 431 LEU A C   1 
ATOM   2501 O O   . LEU A 1 400 ? 105.749 152.465 116.859 1.00 52.39  ? 431 LEU A O   1 
ATOM   2502 C CB  . LEU A 1 400 ? 108.003 150.769 116.881 1.00 47.00  ? 431 LEU A CB  1 
ATOM   2503 C CG  . LEU A 1 400 ? 108.380 149.464 116.198 1.00 48.26  ? 431 LEU A CG  1 
ATOM   2504 C CD1 . LEU A 1 400 ? 108.453 148.366 117.215 1.00 49.45  ? 431 LEU A CD1 1 
ATOM   2505 C CD2 . LEU A 1 400 ? 107.350 149.119 115.150 1.00 46.55  ? 431 LEU A CD2 1 
ATOM   2506 N N   . LEU A 1 401 ? 107.172 154.232 116.622 1.00 48.96  ? 432 LEU A N   1 
ATOM   2507 C CA  . LEU A 1 401 ? 106.298 155.346 117.040 1.00 51.68  ? 432 LEU A CA  1 
ATOM   2508 C C   . LEU A 1 401 ? 105.769 155.145 118.461 1.00 51.34  ? 432 LEU A C   1 
ATOM   2509 O O   . LEU A 1 401 ? 104.569 155.196 118.724 1.00 54.21  ? 432 LEU A O   1 
ATOM   2510 C CB  . LEU A 1 401 ? 105.155 155.595 116.040 1.00 52.93  ? 432 LEU A CB  1 
ATOM   2511 C CG  . LEU A 1 401 ? 105.321 156.544 114.845 1.00 60.95  ? 432 LEU A CG  1 
ATOM   2512 C CD1 . LEU A 1 401 ? 106.383 156.105 113.848 1.00 65.74  ? 432 LEU A CD1 1 
ATOM   2513 C CD2 . LEU A 1 401 ? 103.990 156.670 114.136 1.00 50.62  ? 432 LEU A CD2 1 
ATOM   2514 N N   . MET A 1 402 ? 106.692 154.848 119.368 1.00 50.74  ? 433 MET A N   1 
ATOM   2515 C CA  . MET A 1 402 ? 106.425 154.625 120.783 1.00 47.79  ? 433 MET A CA  1 
ATOM   2516 C C   . MET A 1 402 ? 107.537 155.243 121.650 1.00 54.67  ? 433 MET A C   1 
ATOM   2517 O O   . MET A 1 402 ? 107.891 154.753 122.728 1.00 57.94  ? 433 MET A O   1 
ATOM   2518 C CB  . MET A 1 402 ? 106.118 153.130 121.003 1.00 49.09  ? 433 MET A CB  1 
ATOM   2519 C CG  . MET A 1 402 ? 107.232 152.056 121.003 1.00 54.58  ? 433 MET A CG  1 
ATOM   2520 S SD  . MET A 1 402 ? 106.541 150.396 120.928 1.00 68.01  ? 433 MET A SD  1 
ATOM   2521 C CE  . MET A 1 402 ? 108.025 149.404 120.870 1.00 60.47  ? 433 MET A CE  1 
ATOM   2522 N N   . ARG A 1 403 ? 107.988 156.443 121.253 1.00 56.56  ? 434 ARG A N   1 
ATOM   2523 C CA  . ARG A 1 403 ? 109.177 157.049 121.854 1.00 55.10  ? 434 ARG A CA  1 
ATOM   2524 C C   . ARG A 1 403 ? 108.881 157.719 123.195 1.00 57.60  ? 434 ARG A C   1 
ATOM   2525 O O   . ARG A 1 403 ? 109.810 158.114 123.907 1.00 60.55  ? 434 ARG A O   1 
ATOM   2526 C CB  . ARG A 1 403 ? 109.791 158.074 120.905 1.00 56.18  ? 434 ARG A CB  1 
ATOM   2527 C CG  . ARG A 1 403 ? 108.975 159.342 120.768 1.00 62.49  ? 434 ARG A CG  1 
ATOM   2528 C CD  . ARG A 1 403 ? 109.295 160.096 119.490 1.00 70.48  ? 434 ARG A CD  1 
ATOM   2529 N NE  . ARG A 1 403 ? 109.210 159.244 118.313 1.00 69.58  ? 434 ARG A NE  1 
ATOM   2530 C CZ  . ARG A 1 403 ? 110.093 159.247 117.326 1.00 69.43  ? 434 ARG A CZ  1 
ATOM   2531 N NH1 . ARG A 1 403 ? 111.150 160.041 117.350 1.00 63.27  ? 434 ARG A NH1 1 
ATOM   2532 N NH2 . ARG A 1 403 ? 109.911 158.434 116.291 1.00 72.32  ? 434 ARG A NH2 1 
ATOM   2533 N N   . LYS A 1 404 ? 107.606 157.859 123.565 1.00 57.34  ? 435 LYS A N   1 
ATOM   2534 C CA  . LYS A 1 404 ? 107.261 158.345 124.895 1.00 50.95  ? 435 LYS A CA  1 
ATOM   2535 C C   . LYS A 1 404 ? 107.291 157.255 125.953 1.00 52.01  ? 435 LYS A C   1 
ATOM   2536 O O   . LYS A 1 404 ? 107.127 157.566 127.136 1.00 56.44  ? 435 LYS A O   1 
ATOM   2537 C CB  . LYS A 1 404 ? 105.879 158.994 124.901 1.00 50.19  ? 435 LYS A CB  1 
ATOM   2538 C CG  . LYS A 1 404 ? 105.825 160.403 124.369 1.00 51.41  ? 435 LYS A CG  1 
ATOM   2539 C CD  . LYS A 1 404 ? 104.447 160.985 124.608 1.00 52.06  ? 435 LYS A CD  1 
ATOM   2540 C CE  . LYS A 1 404 ? 104.366 162.430 124.167 1.00 53.69  ? 435 LYS A CE  1 
ATOM   2541 N NZ  . LYS A 1 404 ? 102.966 162.926 124.232 1.00 55.15  ? 435 LYS A NZ  1 
ATOM   2542 N N   . LEU A 1 405 ? 107.495 155.998 125.572 1.00 52.38  ? 436 LEU A N   1 
ATOM   2543 C CA  . LEU A 1 405 ? 107.596 154.903 126.524 1.00 55.66  ? 436 LEU A CA  1 
ATOM   2544 C C   . LEU A 1 405 ? 109.000 154.710 127.068 1.00 55.97  ? 436 LEU A C   1 
ATOM   2545 O O   . LEU A 1 405 ? 109.210 153.773 127.840 1.00 59.15  ? 436 LEU A O   1 
ATOM   2546 C CB  . LEU A 1 405 ? 107.141 153.579 125.903 1.00 55.99  ? 436 LEU A CB  1 
ATOM   2547 C CG  . LEU A 1 405 ? 105.676 153.159 125.944 1.00 54.50  ? 436 LEU A CG  1 
ATOM   2548 C CD1 . LEU A 1 405 ? 104.877 153.867 124.890 1.00 52.26  ? 436 LEU A CD1 1 
ATOM   2549 C CD2 . LEU A 1 405 ? 105.567 151.657 125.779 1.00 57.08  ? 436 LEU A CD2 1 
ATOM   2550 N N   . GLY A 1 406 ? 109.960 155.549 126.676 1.00 52.41  ? 437 GLY A N   1 
ATOM   2551 C CA  . GLY A 1 406 ? 111.319 155.389 127.169 1.00 52.98  ? 437 GLY A CA  1 
ATOM   2552 C C   . GLY A 1 406 ? 111.476 155.819 128.614 1.00 49.26  ? 437 GLY A C   1 
ATOM   2553 O O   . GLY A 1 406 ? 112.342 155.319 129.332 1.00 47.41  ? 437 GLY A O   1 
ATOM   2554 N N   . THR A 1 407 ? 110.628 156.743 129.064 1.00 49.89  ? 438 THR A N   1 
ATOM   2555 C CA  . THR A 1 407 ? 110.635 157.118 130.471 1.00 47.31  ? 438 THR A CA  1 
ATOM   2556 C C   . THR A 1 407 ? 109.943 156.063 131.322 1.00 45.12  ? 438 THR A C   1 
ATOM   2557 O O   . THR A 1 407 ? 110.241 155.924 132.512 1.00 47.47  ? 438 THR A O   1 
ATOM   2558 C CB  . THR A 1 407 ? 109.968 158.478 130.656 1.00 50.79  ? 438 THR A CB  1 
ATOM   2559 O OG1 . THR A 1 407 ? 108.568 158.363 130.383 1.00 53.66  ? 438 THR A OG1 1 
ATOM   2560 C CG2 . THR A 1 407 ? 110.578 159.494 129.708 1.00 46.69  ? 438 THR A CG2 1 
ATOM   2561 N N   . ALA A 1 408 ? 109.015 155.311 130.730 1.00 44.65  ? 439 ALA A N   1 
ATOM   2562 C CA  . ALA A 1 408 ? 108.264 154.308 131.473 1.00 46.82  ? 439 ALA A CA  1 
ATOM   2563 C C   . ALA A 1 408 ? 108.901 152.927 131.424 1.00 45.38  ? 439 ALA A C   1 
ATOM   2564 O O   . ALA A 1 408 ? 108.423 152.023 132.118 1.00 48.46  ? 439 ALA A O   1 
ATOM   2565 C CB  . ALA A 1 408 ? 106.831 154.232 130.946 1.00 46.45  ? 439 ALA A CB  1 
ATOM   2566 N N   . MET A 1 409 ? 109.951 152.738 130.630 1.00 40.21  ? 440 MET A N   1 
ATOM   2567 C CA  . MET A 1 409 ? 110.655 151.460 130.552 1.00 36.88  ? 440 MET A CA  1 
ATOM   2568 C C   . MET A 1 409 ? 111.751 151.462 131.606 1.00 37.54  ? 440 MET A C   1 
ATOM   2569 O O   . MET A 1 409 ? 112.836 152.001 131.383 1.00 50.42  ? 440 MET A O   1 
ATOM   2570 C CB  . MET A 1 409 ? 111.242 151.251 129.162 1.00 44.16  ? 440 MET A CB  1 
ATOM   2571 C CG  . MET A 1 409 ? 110.300 150.632 128.159 1.00 52.27  ? 440 MET A CG  1 
ATOM   2572 S SD  . MET A 1 409 ? 111.028 150.462 126.526 1.00 76.18  ? 440 MET A SD  1 
ATOM   2573 C CE  . MET A 1 409 ? 109.741 149.538 125.698 1.00 58.92  ? 440 MET A CE  1 
ATOM   2574 N N   . ASN A 1 410 ? 111.483 150.852 132.758 1.00 30.87  ? 441 ASN A N   1 
ATOM   2575 C CA  . ASN A 1 410 ? 112.454 150.806 133.839 1.00 25.19  ? 441 ASN A CA  1 
ATOM   2576 C C   . ASN A 1 410 ? 112.604 149.381 134.337 1.00 23.79  ? 441 ASN A C   1 
ATOM   2577 O O   . ASN A 1 410 ? 111.694 148.563 134.186 1.00 31.34  ? 441 ASN A O   1 
ATOM   2578 C CB  . ASN A 1 410 ? 112.051 151.702 135.009 1.00 23.89  ? 441 ASN A CB  1 
ATOM   2579 C CG  . ASN A 1 410 ? 111.960 153.153 134.627 1.00 27.41  ? 441 ASN A CG  1 
ATOM   2580 O OD1 . ASN A 1 410 ? 112.966 153.849 134.543 1.00 28.79  ? 441 ASN A OD1 1 
ATOM   2581 N ND2 . ASN A 1 410 ? 110.746 153.631 134.420 1.00 31.16  ? 441 ASN A ND2 1 
ATOM   2582 N N   . PHE A 1 411 ? 113.761 149.087 134.914 1.00 20.06  ? 442 PHE A N   1 
ATOM   2583 C CA  . PHE A 1 411 ? 113.986 147.868 135.674 1.00 19.06  ? 442 PHE A CA  1 
ATOM   2584 C C   . PHE A 1 411 ? 114.377 148.269 137.088 1.00 22.87  ? 442 PHE A C   1 
ATOM   2585 O O   . PHE A 1 411 ? 115.459 148.825 137.297 1.00 29.50  ? 442 PHE A O   1 
ATOM   2586 C CB  . PHE A 1 411 ? 115.074 147.013 135.035 1.00 19.53  ? 442 PHE A CB  1 
ATOM   2587 C CG  . PHE A 1 411 ? 115.167 145.643 135.612 1.00 20.64  ? 442 PHE A CG  1 
ATOM   2588 C CD1 . PHE A 1 411 ? 114.203 144.687 135.313 1.00 23.82  ? 442 PHE A CD1 1 
ATOM   2589 C CD2 . PHE A 1 411 ? 116.212 145.312 136.464 1.00 20.44  ? 442 PHE A CD2 1 
ATOM   2590 C CE1 . PHE A 1 411 ? 114.276 143.412 135.863 1.00 27.12  ? 442 PHE A CE1 1 
ATOM   2591 C CE2 . PHE A 1 411 ? 116.301 144.042 137.019 1.00 21.70  ? 442 PHE A CE2 1 
ATOM   2592 C CZ  . PHE A 1 411 ? 115.327 143.095 136.710 1.00 27.01  ? 442 PHE A CZ  1 
ATOM   2593 N N   . GLN A 1 412 ? 113.507 147.990 138.055 1.00 20.62  ? 443 GLN A N   1 
ATOM   2594 C CA  . GLN A 1 412 ? 113.598 148.608 139.367 1.00 22.78  ? 443 GLN A CA  1 
ATOM   2595 C C   . GLN A 1 412 ? 113.856 147.578 140.457 1.00 26.13  ? 443 GLN A C   1 
ATOM   2596 O O   . GLN A 1 412 ? 113.635 146.381 140.271 1.00 29.64  ? 443 GLN A O   1 
ATOM   2597 C CB  . GLN A 1 412 ? 112.325 149.393 139.678 1.00 21.39  ? 443 GLN A CB  1 
ATOM   2598 C CG  . GLN A 1 412 ? 112.178 150.604 138.789 1.00 26.91  ? 443 GLN A CG  1 
ATOM   2599 C CD  . GLN A 1 412 ? 111.017 151.484 139.157 1.00 31.99  ? 443 GLN A CD  1 
ATOM   2600 O OE1 . GLN A 1 412 ? 110.238 151.161 140.041 1.00 37.14  ? 443 GLN A OE1 1 
ATOM   2601 N NE2 . GLN A 1 412 ? 110.912 152.630 138.497 1.00 28.61  ? 443 GLN A NE2 1 
ATOM   2602 N N   . MET A 1 413 ? 114.350 148.055 141.595 1.00 24.79  ? 444 MET A N   1 
ATOM   2603 C CA  . MET A 1 413 ? 114.532 147.230 142.780 1.00 23.76  ? 444 MET A CA  1 
ATOM   2604 C C   . MET A 1 413 ? 113.626 147.734 143.893 1.00 27.97  ? 444 MET A C   1 
ATOM   2605 O O   . MET A 1 413 ? 113.666 148.917 144.239 1.00 31.37  ? 444 MET A O   1 
ATOM   2606 C CB  . MET A 1 413 ? 115.987 147.222 143.244 1.00 28.89  ? 444 MET A CB  1 
ATOM   2607 C CG  . MET A 1 413 ? 116.313 146.083 144.201 1.00 32.55  ? 444 MET A CG  1 
ATOM   2608 S SD  . MET A 1 413 ? 118.070 145.747 144.431 1.00 42.80  ? 444 MET A SD  1 
ATOM   2609 C CE  . MET A 1 413 ? 118.756 147.399 144.419 1.00 26.77  ? 444 MET A CE  1 
ATOM   2610 N N   . TYR A 1 414 ? 112.812 146.837 144.444 1.00 27.48  ? 445 TYR A N   1 
ATOM   2611 C CA  . TYR A 1 414 ? 111.833 147.168 145.468 1.00 26.53  ? 445 TYR A CA  1 
ATOM   2612 C C   . TYR A 1 414 ? 112.151 146.407 146.741 1.00 31.24  ? 445 TYR A C   1 
ATOM   2613 O O   . TYR A 1 414 ? 112.481 145.225 146.692 1.00 40.50  ? 445 TYR A O   1 
ATOM   2614 C CB  . TYR A 1 414 ? 110.423 146.791 145.036 1.00 26.18  ? 445 TYR A CB  1 
ATOM   2615 C CG  . TYR A 1 414 ? 109.825 147.648 143.961 1.00 27.43  ? 445 TYR A CG  1 
ATOM   2616 C CD1 . TYR A 1 414 ? 109.310 148.908 144.266 1.00 30.69  ? 445 TYR A CD1 1 
ATOM   2617 C CD2 . TYR A 1 414 ? 109.740 147.183 142.646 1.00 26.84  ? 445 TYR A CD2 1 
ATOM   2618 C CE1 . TYR A 1 414 ? 108.737 149.701 143.284 1.00 30.98  ? 445 TYR A CE1 1 
ATOM   2619 C CE2 . TYR A 1 414 ? 109.173 147.966 141.650 1.00 29.96  ? 445 TYR A CE2 1 
ATOM   2620 C CZ  . TYR A 1 414 ? 108.673 149.221 141.985 1.00 32.18  ? 445 TYR A CZ  1 
ATOM   2621 O OH  . TYR A 1 414 ? 108.111 150.012 141.012 1.00 34.36  ? 445 TYR A OH  1 
ATOM   2622 N N   . GLN A 1 415 ? 112.014 147.069 147.884 1.00 26.62  ? 446 GLN A N   1 
ATOM   2623 C CA  . GLN A 1 415 ? 112.189 146.428 149.180 1.00 27.55  ? 446 GLN A CA  1 
ATOM   2624 C C   . GLN A 1 415 ? 110.846 146.364 149.887 1.00 33.52  ? 446 GLN A C   1 
ATOM   2625 O O   . GLN A 1 415 ? 110.227 147.402 150.135 1.00 43.65  ? 446 GLN A O   1 
ATOM   2626 C CB  . GLN A 1 415 ? 113.188 147.186 150.052 1.00 29.16  ? 446 GLN A CB  1 
ATOM   2627 C CG  . GLN A 1 415 ? 113.333 146.601 151.439 1.00 34.10  ? 446 GLN A CG  1 
ATOM   2628 C CD  . GLN A 1 415 ? 114.721 146.762 152.017 1.00 42.66  ? 446 GLN A CD  1 
ATOM   2629 O OE1 . GLN A 1 415 ? 115.394 147.764 151.783 1.00 52.35  ? 446 GLN A OE1 1 
ATOM   2630 N NE2 . GLN A 1 415 ? 115.162 145.769 152.773 1.00 40.96  ? 446 GLN A NE2 1 
ATOM   2631 N N   . LYS A 1 416 ? 110.405 145.156 150.226 1.00 29.87  ? 447 LYS A N   1 
ATOM   2632 C CA  . LYS A 1 416 ? 109.143 144.957 150.926 1.00 26.28  ? 447 LYS A CA  1 
ATOM   2633 C C   . LYS A 1 416 ? 109.359 145.266 152.399 1.00 31.05  ? 447 LYS A C   1 
ATOM   2634 O O   . LYS A 1 416 ? 110.048 144.519 153.092 1.00 42.26  ? 447 LYS A O   1 
ATOM   2635 C CB  . LYS A 1 416 ? 108.650 143.522 150.739 1.00 26.73  ? 447 LYS A CB  1 
ATOM   2636 C CG  . LYS A 1 416 ? 107.449 143.110 151.595 1.00 35.20  ? 447 LYS A CG  1 
ATOM   2637 C CD  . LYS A 1 416 ? 107.039 141.687 151.295 1.00 39.68  ? 447 LYS A CD  1 
ATOM   2638 C CE  . LYS A 1 416 ? 105.948 141.197 152.226 1.00 41.11  ? 447 LYS A CE  1 
ATOM   2639 N NZ  . LYS A 1 416 ? 106.452 140.936 153.601 1.00 51.36  ? 447 LYS A NZ  1 
ATOM   2640 N N   . LYS A 1 417 ? 108.808 146.372 152.879 1.00 30.32  ? 448 LYS A N   1 
ATOM   2641 C CA  . LYS A 1 417 ? 108.900 146.710 154.293 1.00 40.28  ? 448 LYS A CA  1 
ATOM   2642 C C   . LYS A 1 417 ? 107.504 146.779 154.882 1.00 44.98  ? 448 LYS A C   1 
ATOM   2643 O O   . LYS A 1 417 ? 106.699 147.621 154.477 1.00 52.97  ? 448 LYS A O   1 
ATOM   2644 C CB  . LYS A 1 417 ? 109.643 148.025 154.525 1.00 46.76  ? 448 LYS A CB  1 
ATOM   2645 C CG  . LYS A 1 417 ? 111.094 148.015 154.095 1.00 47.86  ? 448 LYS A CG  1 
ATOM   2646 C CD  . LYS A 1 417 ? 111.923 148.953 154.951 1.00 48.60  ? 448 LYS A CD  1 
ATOM   2647 C CE  . LYS A 1 417 ? 113.401 148.788 154.682 1.00 55.45  ? 448 LYS A CE  1 
ATOM   2648 N NZ  . LYS A 1 417 ? 114.206 149.733 155.499 1.00 65.03  ? 448 LYS A NZ  1 
ATOM   2649 N N   . VAL A 1 418 ? 107.228 145.903 155.845 1.00 47.44  ? 449 VAL A N   1 
ATOM   2650 C CA  . VAL A 1 418 ? 105.928 145.855 156.511 1.00 56.50  ? 449 VAL A CA  1 
ATOM   2651 C C   . VAL A 1 418 ? 106.005 146.867 157.651 1.00 60.29  ? 449 VAL A C   1 
ATOM   2652 O O   . VAL A 1 418 ? 106.876 146.802 158.517 1.00 60.04  ? 449 VAL A O   1 
ATOM   2653 C CB  . VAL A 1 418 ? 105.585 144.448 156.993 1.00 56.92  ? 449 VAL A CB  1 
ATOM   2654 C CG1 . VAL A 1 418 ? 104.276 144.440 157.776 1.00 54.22  ? 449 VAL A CG1 1 
ATOM   2655 C CG2 . VAL A 1 418 ? 105.512 143.494 155.810 1.00 51.13  ? 449 VAL A CG2 1 
ATOM   2656 N N   . LEU A 1 419 ? 105.083 147.823 157.638 1.00 63.54  ? 450 LEU A N   1 
ATOM   2657 C CA  . LEU A 1 419 ? 105.091 148.902 158.617 1.00 68.69  ? 450 LEU A CA  1 
ATOM   2658 C C   . LEU A 1 419 ? 104.291 148.489 159.846 1.00 70.08  ? 450 LEU A C   1 
ATOM   2659 O O   . LEU A 1 419 ? 103.893 149.332 160.651 1.00 73.20  ? 450 LEU A O   1 
ATOM   2660 C CB  . LEU A 1 419 ? 104.517 150.205 158.033 1.00 69.50  ? 450 LEU A CB  1 
ATOM   2661 C CG  . LEU A 1 419 ? 105.308 151.140 157.097 1.00 66.05  ? 450 LEU A CG  1 
ATOM   2662 C CD1 . LEU A 1 419 ? 105.484 150.601 155.673 1.00 60.95  ? 450 LEU A CD1 1 
ATOM   2663 C CD2 . LEU A 1 419 ? 104.686 152.532 157.080 1.00 65.67  ? 450 LEU A CD2 1 
ATOM   2664 N N   . THR A 1 430 ? 102.227 146.197 155.087 1.00 34.96  ? 461 THR A N   1 
ATOM   2665 C CA  . THR A 1 430 ? 102.933 145.661 153.929 1.00 41.44  ? 461 THR A CA  1 
ATOM   2666 C C   . THR A 1 430 ? 102.976 146.676 152.800 1.00 42.03  ? 461 THR A C   1 
ATOM   2667 O O   . THR A 1 430 ? 101.939 147.018 152.236 1.00 47.82  ? 461 THR A O   1 
ATOM   2668 C CB  . THR A 1 430 ? 102.274 144.371 153.406 1.00 44.32  ? 461 THR A CB  1 
ATOM   2669 O OG1 . THR A 1 430 ? 102.087 143.446 154.486 1.00 47.15  ? 461 THR A OG1 1 
ATOM   2670 C CG2 . THR A 1 430 ? 103.140 143.733 152.337 1.00 41.67  ? 461 THR A CG2 1 
ATOM   2671 N N   . GLU A 1 431 ? 104.172 147.153 152.463 1.00 36.46  ? 462 GLU A N   1 
ATOM   2672 C CA  . GLU A 1 431 ? 104.337 148.154 151.418 1.00 39.66  ? 462 GLU A CA  1 
ATOM   2673 C C   . GLU A 1 431 ? 105.715 148.026 150.795 1.00 39.47  ? 462 GLU A C   1 
ATOM   2674 O O   . GLU A 1 431 ? 106.724 148.258 151.466 1.00 46.68  ? 462 GLU A O   1 
ATOM   2675 C CB  . GLU A 1 431 ? 104.146 149.569 151.967 1.00 45.79  ? 462 GLU A CB  1 
ATOM   2676 C CG  . GLU A 1 431 ? 104.254 150.639 150.902 1.00 51.57  ? 462 GLU A CG  1 
ATOM   2677 C CD  . GLU A 1 431 ? 104.464 152.021 151.477 1.00 66.80  ? 462 GLU A CD  1 
ATOM   2678 O OE1 . GLU A 1 431 ? 104.742 152.125 152.689 1.00 74.19  ? 462 GLU A OE1 1 
ATOM   2679 O OE2 . GLU A 1 431 ? 104.350 153.004 150.716 1.00 71.88  ? 462 GLU A OE2 1 
ATOM   2680 N N   . LEU A 1 432 ? 105.751 147.674 149.512 1.00 36.33  ? 463 LEU A N   1 
ATOM   2681 C CA  . LEU A 1 432 ? 106.993 147.532 148.752 1.00 33.94  ? 463 LEU A CA  1 
ATOM   2682 C C   . LEU A 1 432 ? 107.490 148.913 148.347 1.00 32.64  ? 463 LEU A C   1 
ATOM   2683 O O   . LEU A 1 432 ? 107.166 149.400 147.263 1.00 32.73  ? 463 LEU A O   1 
ATOM   2684 C CB  . LEU A 1 432 ? 106.783 146.661 147.518 1.00 26.13  ? 463 LEU A CB  1 
ATOM   2685 C CG  . LEU A 1 432 ? 107.013 145.153 147.609 1.00 23.01  ? 463 LEU A CG  1 
ATOM   2686 C CD1 . LEU A 1 432 ? 105.878 144.426 148.312 1.00 25.40  ? 463 LEU A CD1 1 
ATOM   2687 C CD2 . LEU A 1 432 ? 107.227 144.604 146.218 1.00 15.76  ? 463 LEU A CD2 1 
ATOM   2688 N N   . ARG A 1 433 ? 108.277 149.546 149.212 1.00 33.69  ? 464 ARG A N   1 
ATOM   2689 C CA  . ARG A 1 433 ? 108.853 150.824 148.836 1.00 34.62  ? 464 ARG A CA  1 
ATOM   2690 C C   . ARG A 1 433 ? 110.068 150.625 147.938 1.00 33.88  ? 464 ARG A C   1 
ATOM   2691 O O   . ARG A 1 433 ? 110.692 149.563 147.918 1.00 34.62  ? 464 ARG A O   1 
ATOM   2692 C CB  . ARG A 1 433 ? 109.192 151.663 150.068 1.00 38.95  ? 464 ARG A CB  1 
ATOM   2693 C CG  . ARG A 1 433 ? 108.078 151.703 151.102 1.00 46.49  ? 464 ARG A CG  1 
ATOM   2694 C CD  . ARG A 1 433 ? 108.430 152.575 152.295 1.00 58.43  ? 464 ARG A CD  1 
ATOM   2695 N NE  . ARG A 1 433 ? 109.107 151.857 153.368 1.00 77.30  ? 464 ARG A NE  1 
ATOM   2696 C CZ  . ARG A 1 433 ? 108.861 152.046 154.657 1.00 84.66  ? 464 ARG A CZ  1 
ATOM   2697 N NH1 . ARG A 1 433 ? 107.970 152.940 155.064 1.00 86.37  ? 464 ARG A NH1 1 
ATOM   2698 N NH2 . ARG A 1 433 ? 109.532 151.332 155.560 1.00 75.85  ? 464 ARG A NH2 1 
ATOM   2699 N N   . GLU A 1 434 ? 110.393 151.671 147.183 1.00 33.74  ? 465 GLU A N   1 
ATOM   2700 C CA  . GLU A 1 434 ? 111.298 151.588 146.043 1.00 32.67  ? 465 GLU A CA  1 
ATOM   2701 C C   . GLU A 1 434 ? 112.722 151.881 146.483 1.00 36.47  ? 465 GLU A C   1 
ATOM   2702 O O   . GLU A 1 434 ? 112.958 152.815 147.252 1.00 42.72  ? 465 GLU A O   1 
ATOM   2703 C CB  . GLU A 1 434 ? 110.880 152.560 144.943 1.00 35.23  ? 465 GLU A CB  1 
ATOM   2704 C CG  . GLU A 1 434 ? 111.414 152.203 143.571 1.00 38.01  ? 465 GLU A CG  1 
ATOM   2705 C CD  . GLU A 1 434 ? 111.538 153.403 142.662 1.00 38.58  ? 465 GLU A CD  1 
ATOM   2706 O OE1 . GLU A 1 434 ? 111.031 154.486 143.020 1.00 44.53  ? 465 GLU A OE1 1 
ATOM   2707 O OE2 . GLU A 1 434 ? 112.129 153.257 141.576 1.00 35.20  ? 465 GLU A OE2 1 
ATOM   2708 N N   . ILE A 1 435 ? 113.664 151.083 145.986 1.00 33.29  ? 466 ILE A N   1 
ATOM   2709 C CA  . ILE A 1 435 ? 115.084 151.293 146.240 1.00 31.25  ? 466 ILE A CA  1 
ATOM   2710 C C   . ILE A 1 435 ? 115.804 151.869 145.028 1.00 35.20  ? 466 ILE A C   1 
ATOM   2711 O O   . ILE A 1 435 ? 116.422 152.940 145.145 1.00 36.76  ? 466 ILE A O   1 
ATOM   2712 C CB  . ILE A 1 435 ? 115.764 149.982 146.703 1.00 29.22  ? 466 ILE A CB  1 
ATOM   2713 C CG1 . ILE A 1 435 ? 115.345 149.591 148.123 1.00 26.50  ? 466 ILE A CG1 1 
ATOM   2714 C CG2 . ILE A 1 435 ? 117.283 150.090 146.720 1.00 34.31  ? 466 ILE A CG2 1 
ATOM   2715 C CD1 . ILE A 1 435 ? 115.365 150.702 149.166 1.00 30.11  ? 466 ILE A CD1 1 
ATOM   2716 N N   . ALA A 1 436 ? 115.691 151.239 143.863 1.00 32.73  ? 467 ALA A N   1 
ATOM   2717 C CA  . ALA A 1 436 ? 116.503 151.599 142.713 1.00 29.15  ? 467 ALA A CA  1 
ATOM   2718 C C   . ALA A 1 436 ? 115.630 151.684 141.475 1.00 34.71  ? 467 ALA A C   1 
ATOM   2719 O O   . ALA A 1 436 ? 114.467 151.276 141.491 1.00 42.67  ? 467 ALA A O   1 
ATOM   2720 C CB  . ALA A 1 436 ? 117.609 150.579 142.497 1.00 29.21  ? 467 ALA A CB  1 
ATOM   2721 N N   . SER A 1 437 ? 116.217 152.206 140.395 1.00 29.30  ? 468 SER A N   1 
ATOM   2722 C CA  . SER A 1 437 ? 115.567 152.267 139.091 1.00 27.52  ? 468 SER A CA  1 
ATOM   2723 C C   . SER A 1 437 ? 116.629 152.378 138.012 1.00 26.10  ? 468 SER A C   1 
ATOM   2724 O O   . SER A 1 437 ? 117.399 153.338 138.004 1.00 33.52  ? 468 SER A O   1 
ATOM   2725 C CB  . SER A 1 437 ? 114.615 153.462 138.976 1.00 29.78  ? 468 SER A CB  1 
ATOM   2726 O OG  . SER A 1 437 ? 115.314 154.637 138.617 1.00 35.47  ? 468 SER A OG  1 
ATOM   2727 N N   . GLN A 1 438 ? 116.654 151.416 137.094 1.00 23.03  ? 469 GLN A N   1 
ATOM   2728 C CA  . GLN A 1 438 ? 117.550 151.468 135.943 1.00 22.87  ? 469 GLN A CA  1 
ATOM   2729 C C   . GLN A 1 438 ? 116.716 151.555 134.682 1.00 25.22  ? 469 GLN A C   1 
ATOM   2730 O O   . GLN A 1 438 ? 115.899 150.669 134.419 1.00 33.21  ? 469 GLN A O   1 
ATOM   2731 C CB  . GLN A 1 438 ? 118.460 150.245 135.872 1.00 22.82  ? 469 GLN A CB  1 
ATOM   2732 C CG  . GLN A 1 438 ? 119.381 150.262 134.675 1.00 23.13  ? 469 GLN A CG  1 
ATOM   2733 C CD  . GLN A 1 438 ? 120.349 149.107 134.671 1.00 29.70  ? 469 GLN A CD  1 
ATOM   2734 O OE1 . GLN A 1 438 ? 120.212 148.167 135.449 1.00 37.51  ? 469 GLN A OE1 1 
ATOM   2735 N NE2 . GLN A 1 438 ? 121.338 149.170 133.791 1.00 34.39  ? 469 GLN A NE2 1 
ATOM   2736 N N   . ASN A 1 439 ? 116.933 152.605 133.899 1.00 23.60  ? 470 ASN A N   1 
ATOM   2737 C CA  . ASN A 1 439 ? 116.145 152.815 132.696 1.00 20.73  ? 470 ASN A CA  1 
ATOM   2738 C C   . ASN A 1 439 ? 116.629 151.900 131.578 1.00 23.78  ? 470 ASN A C   1 
ATOM   2739 O O   . ASN A 1 439 ? 117.760 151.412 131.603 1.00 29.67  ? 470 ASN A O   1 
ATOM   2740 C CB  . ASN A 1 439 ? 116.229 154.275 132.273 1.00 19.96  ? 470 ASN A CB  1 
ATOM   2741 C CG  . ASN A 1 439 ? 115.052 154.705 131.454 1.00 26.14  ? 470 ASN A CG  1 
ATOM   2742 O OD1 . ASN A 1 439 ? 115.053 154.561 130.239 1.00 29.92  ? 470 ASN A OD1 1 
ATOM   2743 N ND2 . ASN A 1 439 ? 114.035 155.239 132.111 1.00 29.37  ? 470 ASN A ND2 1 
ATOM   2744 N N   . PHE A 1 440 ? 115.754 151.642 130.606 1.00 24.47  ? 471 PHE A N   1 
ATOM   2745 C CA  . PHE A 1 440 ? 116.106 150.739 129.516 1.00 23.82  ? 471 PHE A CA  1 
ATOM   2746 C C   . PHE A 1 440 ? 116.831 151.466 128.391 1.00 20.26  ? 471 PHE A C   1 
ATOM   2747 O O   . PHE A 1 440 ? 117.719 150.893 127.750 1.00 17.46  ? 471 PHE A O   1 
ATOM   2748 C CB  . PHE A 1 440 ? 114.852 150.057 128.974 1.00 22.66  ? 471 PHE A CB  1 
ATOM   2749 C CG  . PHE A 1 440 ? 114.572 148.719 129.582 1.00 14.97  ? 471 PHE A CG  1 
ATOM   2750 C CD1 . PHE A 1 440 ? 114.318 148.598 130.942 1.00 13.97  ? 471 PHE A CD1 1 
ATOM   2751 C CD2 . PHE A 1 440 ? 114.559 147.578 128.781 1.00 15.54  ? 471 PHE A CD2 1 
ATOM   2752 C CE1 . PHE A 1 440 ? 114.052 147.351 131.504 1.00 18.93  ? 471 PHE A CE1 1 
ATOM   2753 C CE2 . PHE A 1 440 ? 114.299 146.328 129.329 1.00 17.18  ? 471 PHE A CE2 1 
ATOM   2754 C CZ  . PHE A 1 440 ? 114.044 146.217 130.693 1.00 17.91  ? 471 PHE A CZ  1 
ATOM   2755 N N   . VAL A 1 441 ? 116.460 152.719 128.124 1.00 21.62  ? 472 VAL A N   1 
ATOM   2756 C CA  . VAL A 1 441 ? 116.964 153.406 126.938 1.00 27.16  ? 472 VAL A CA  1 
ATOM   2757 C C   . VAL A 1 441 ? 118.352 153.971 127.195 1.00 32.95  ? 472 VAL A C   1 
ATOM   2758 O O   . VAL A 1 441 ? 119.331 153.570 126.556 1.00 37.97  ? 472 VAL A O   1 
ATOM   2759 C CB  . VAL A 1 441 ? 115.981 154.502 126.498 1.00 29.49  ? 472 VAL A CB  1 
ATOM   2760 C CG1 . VAL A 1 441 ? 116.507 155.231 125.277 1.00 32.24  ? 472 VAL A CG1 1 
ATOM   2761 C CG2 . VAL A 1 441 ? 114.644 153.883 126.192 1.00 28.99  ? 472 VAL A CG2 1 
ATOM   2762 N N   . THR A 1 442 ? 118.460 154.907 128.129 1.00 31.66  ? 473 THR A N   1 
ATOM   2763 C CA  . THR A 1 442 ? 119.745 155.375 128.623 1.00 31.63  ? 473 THR A CA  1 
ATOM   2764 C C   . THR A 1 442 ? 119.927 154.768 129.999 1.00 28.26  ? 473 THR A C   1 
ATOM   2765 O O   . THR A 1 442 ? 119.212 155.144 130.932 1.00 33.86  ? 473 THR A O   1 
ATOM   2766 C CB  . THR A 1 442 ? 119.794 156.900 128.706 1.00 33.74  ? 473 THR A CB  1 
ATOM   2767 O OG1 . THR A 1 442 ? 118.798 157.356 129.628 1.00 32.45  ? 473 THR A OG1 1 
ATOM   2768 C CG2 . THR A 1 442 ? 119.534 157.518 127.343 1.00 41.70  ? 473 THR A CG2 1 
ATOM   2769 N N   . ASN A 1 443 ? 120.888 153.850 130.139 1.00 23.23  ? 474 ASN A N   1 
ATOM   2770 C CA  . ASN A 1 443 ? 121.030 153.053 131.363 1.00 20.47  ? 474 ASN A CA  1 
ATOM   2771 C C   . ASN A 1 443 ? 121.669 153.883 132.479 1.00 26.29  ? 474 ASN A C   1 
ATOM   2772 O O   . ASN A 1 443 ? 122.843 153.737 132.825 1.00 30.65  ? 474 ASN A O   1 
ATOM   2773 C CB  . ASN A 1 443 ? 121.857 151.803 131.110 1.00 24.23  ? 474 ASN A CB  1 
ATOM   2774 C CG  . ASN A 1 443 ? 121.518 151.116 129.812 1.00 28.68  ? 474 ASN A CG  1 
ATOM   2775 O OD1 . ASN A 1 443 ? 120.448 150.535 129.659 1.00 27.59  ? 474 ASN A OD1 1 
ATOM   2776 N ND2 . ASN A 1 443 ? 122.451 151.168 128.868 1.00 36.01  ? 474 ASN A ND2 1 
ATOM   2777 N N   . VAL A 1 444 ? 120.860 154.756 133.064 1.00 26.99  ? 475 VAL A N   1 
ATOM   2778 C CA  . VAL A 1 444 ? 121.263 155.584 134.185 1.00 28.83  ? 475 VAL A CA  1 
ATOM   2779 C C   . VAL A 1 444 ? 120.566 155.005 135.399 1.00 27.44  ? 475 VAL A C   1 
ATOM   2780 O O   . VAL A 1 444 ? 119.369 155.234 135.604 1.00 26.85  ? 475 VAL A O   1 
ATOM   2781 C CB  . VAL A 1 444 ? 120.893 157.057 133.973 1.00 26.27  ? 475 VAL A CB  1 
ATOM   2782 C CG1 . VAL A 1 444 ? 121.428 157.904 135.110 1.00 22.29  ? 475 VAL A CG1 1 
ATOM   2783 C CG2 . VAL A 1 444 ? 121.430 157.549 132.653 1.00 26.06  ? 475 VAL A CG2 1 
ATOM   2784 N N   . THR A 1 445 ? 121.295 154.210 136.172 1.00 26.41  ? 476 THR A N   1 
ATOM   2785 C CA  . THR A 1 445 ? 120.748 153.664 137.400 1.00 25.71  ? 476 THR A CA  1 
ATOM   2786 C C   . THR A 1 445 ? 120.662 154.759 138.459 1.00 31.18  ? 476 THR A C   1 
ATOM   2787 O O   . THR A 1 445 ? 121.550 155.609 138.578 1.00 36.12  ? 476 THR A O   1 
ATOM   2788 C CB  . THR A 1 445 ? 121.558 152.438 137.854 1.00 24.44  ? 476 THR A CB  1 
ATOM   2789 O OG1 . THR A 1 445 ? 120.965 151.862 139.021 1.00 26.85  ? 476 THR A OG1 1 
ATOM   2790 C CG2 . THR A 1 445 ? 123.058 152.698 138.049 1.00 26.44  ? 476 THR A CG2 1 
ATOM   2791 N N   . THR A 1 446 ? 119.526 154.811 139.140 1.00 30.08  ? 477 THR A N   1 
ATOM   2792 C CA  . THR A 1 446 ? 119.230 155.870 140.092 1.00 30.30  ? 477 THR A CA  1 
ATOM   2793 C C   . THR A 1 446 ? 118.781 155.221 141.387 1.00 32.13  ? 477 THR A C   1 
ATOM   2794 O O   . THR A 1 446 ? 117.795 154.479 141.400 1.00 37.89  ? 477 THR A O   1 
ATOM   2795 C CB  . THR A 1 446 ? 118.155 156.810 139.549 1.00 30.18  ? 477 THR A CB  1 
ATOM   2796 O OG1 . THR A 1 446 ? 118.642 157.456 138.368 1.00 33.97  ? 477 THR A OG1 1 
ATOM   2797 C CG2 . THR A 1 446 ? 117.791 157.863 140.578 1.00 30.47  ? 477 THR A CG2 1 
ATOM   2798 N N   . TYR A 1 447 ? 119.499 155.494 142.466 1.00 31.46  ? 478 TYR A N   1 
ATOM   2799 C CA  . TYR A 1 447 ? 119.230 154.879 143.754 1.00 32.29  ? 478 TYR A CA  1 
ATOM   2800 C C   . TYR A 1 447 ? 118.535 155.886 144.654 1.00 41.16  ? 478 TYR A C   1 
ATOM   2801 O O   . TYR A 1 447 ? 118.955 157.044 144.740 1.00 45.88  ? 478 TYR A O   1 
ATOM   2802 C CB  . TYR A 1 447 ? 120.521 154.371 144.390 1.00 33.07  ? 478 TYR A CB  1 
ATOM   2803 C CG  . TYR A 1 447 ? 121.048 153.129 143.718 1.00 32.73  ? 478 TYR A CG  1 
ATOM   2804 C CD1 . TYR A 1 447 ? 120.647 151.863 144.151 1.00 34.09  ? 478 TYR A CD1 1 
ATOM   2805 C CD2 . TYR A 1 447 ? 121.925 153.222 142.632 1.00 33.24  ? 478 TYR A CD2 1 
ATOM   2806 C CE1 . TYR A 1 447 ? 121.120 150.715 143.528 1.00 35.31  ? 478 TYR A CE1 1 
ATOM   2807 C CE2 . TYR A 1 447 ? 122.397 152.085 141.999 1.00 35.28  ? 478 TYR A CE2 1 
ATOM   2808 C CZ  . TYR A 1 447 ? 121.987 150.842 142.454 1.00 38.02  ? 478 TYR A CZ  1 
ATOM   2809 O OH  . TYR A 1 447 ? 122.460 149.717 141.832 1.00 41.88  ? 478 TYR A OH  1 
ATOM   2810 N N   . TYR A 1 448 ? 117.466 155.445 145.306 1.00 39.67  ? 479 TYR A N   1 
ATOM   2811 C CA  . TYR A 1 448 ? 116.600 156.318 146.082 1.00 42.91  ? 479 TYR A CA  1 
ATOM   2812 C C   . TYR A 1 448 ? 116.872 156.101 147.561 1.00 46.75  ? 479 TYR A C   1 
ATOM   2813 O O   . TYR A 1 448 ? 116.765 154.974 148.056 1.00 47.18  ? 479 TYR A O   1 
ATOM   2814 C CB  . TYR A 1 448 ? 115.131 156.052 145.754 1.00 42.65  ? 479 TYR A CB  1 
ATOM   2815 C CG  . TYR A 1 448 ? 114.784 156.317 144.310 1.00 37.86  ? 479 TYR A CG  1 
ATOM   2816 C CD1 . TYR A 1 448 ? 114.512 157.618 143.874 1.00 40.49  ? 479 TYR A CD1 1 
ATOM   2817 C CD2 . TYR A 1 448 ? 114.737 155.274 143.381 1.00 35.32  ? 479 TYR A CD2 1 
ATOM   2818 C CE1 . TYR A 1 448 ? 114.202 157.876 142.542 1.00 42.10  ? 479 TYR A CE1 1 
ATOM   2819 C CE2 . TYR A 1 448 ? 114.432 155.519 142.048 1.00 38.27  ? 479 TYR A CE2 1 
ATOM   2820 C CZ  . TYR A 1 448 ? 114.164 156.819 141.642 1.00 41.10  ? 479 TYR A CZ  1 
ATOM   2821 O OH  . TYR A 1 448 ? 113.857 157.064 140.325 1.00 46.08  ? 479 TYR A OH  1 
ATOM   2822 N N   . HIS A 1 449 ? 117.220 157.174 148.260 1.00 47.92  ? 480 HIS A N   1 
ATOM   2823 C CA  . HIS A 1 449 ? 117.482 157.131 149.691 1.00 57.63  ? 480 HIS A CA  1 
ATOM   2824 C C   . HIS A 1 449 ? 116.411 157.926 150.422 1.00 64.57  ? 480 HIS A C   1 
ATOM   2825 O O   . HIS A 1 449 ? 116.157 159.088 150.086 1.00 60.43  ? 480 HIS A O   1 
ATOM   2826 C CB  . HIS A 1 449 ? 118.873 157.681 150.012 1.00 52.52  ? 480 HIS A CB  1 
ATOM   2827 C CG  . HIS A 1 449 ? 119.979 156.976 149.291 1.00 51.70  ? 480 HIS A CG  1 
ATOM   2828 N ND1 . HIS A 1 449 ? 120.148 155.610 149.344 1.00 50.54  ? 480 HIS A ND1 1 
ATOM   2829 C CD2 . HIS A 1 449 ? 120.969 157.446 148.496 1.00 53.73  ? 480 HIS A CD2 1 
ATOM   2830 C CE1 . HIS A 1 449 ? 121.194 155.268 148.614 1.00 46.19  ? 480 HIS A CE1 1 
ATOM   2831 N NE2 . HIS A 1 449 ? 121.710 156.364 148.089 1.00 48.33  ? 480 HIS A NE2 1 
ATOM   2832 N N   . TYR A 1 450 ? 115.782 157.294 151.408 1.00 70.49  ? 481 TYR A N   1 
ATOM   2833 C CA  . TYR A 1 450 ? 114.784 157.930 152.256 1.00 75.70  ? 481 TYR A CA  1 
ATOM   2834 C C   . TYR A 1 450 ? 115.456 158.301 153.570 1.00 83.95  ? 481 TYR A C   1 
ATOM   2835 O O   . TYR A 1 450 ? 116.043 157.440 154.231 1.00 82.80  ? 481 TYR A O   1 
ATOM   2836 C CB  . TYR A 1 450 ? 113.600 156.999 152.509 1.00 72.94  ? 481 TYR A CB  1 
ATOM   2837 C CG  . TYR A 1 450 ? 113.001 156.400 151.260 1.00 66.89  ? 481 TYR A CG  1 
ATOM   2838 C CD1 . TYR A 1 450 ? 112.603 157.213 150.191 1.00 64.73  ? 481 TYR A CD1 1 
ATOM   2839 C CD2 . TYR A 1 450 ? 112.820 155.015 151.155 1.00 61.89  ? 481 TYR A CD2 1 
ATOM   2840 C CE1 . TYR A 1 450 ? 112.049 156.658 149.037 1.00 60.20  ? 481 TYR A CE1 1 
ATOM   2841 C CE2 . TYR A 1 450 ? 112.266 154.449 150.012 1.00 56.70  ? 481 TYR A CE2 1 
ATOM   2842 C CZ  . TYR A 1 450 ? 111.884 155.279 148.963 1.00 54.18  ? 481 TYR A CZ  1 
ATOM   2843 O OH  . TYR A 1 450 ? 111.338 154.719 147.833 1.00 46.04  ? 481 TYR A OH  1 
ATOM   2844 N N   . ASN A 1 451 ? 115.367 159.576 153.947 1.00 92.80  ? 482 ASN A N   1 
ATOM   2845 C CA  . ASN A 1 451 ? 116.092 160.096 155.106 1.00 102.91 ? 482 ASN A CA  1 
ATOM   2846 C C   . ASN A 1 451 ? 115.310 159.812 156.388 1.00 105.86 ? 482 ASN A C   1 
ATOM   2847 O O   . ASN A 1 451 ? 114.611 160.664 156.940 1.00 104.95 ? 482 ASN A O   1 
ATOM   2848 C CB  . ASN A 1 451 ? 116.362 161.582 154.929 1.00 110.73 ? 482 ASN A CB  1 
ATOM   2849 C CG  . ASN A 1 451 ? 117.531 162.064 155.761 1.00 114.39 ? 482 ASN A CG  1 
ATOM   2850 O OD1 . ASN A 1 451 ? 118.154 161.288 156.487 1.00 114.57 ? 482 ASN A OD1 1 
ATOM   2851 N ND2 . ASN A 1 451 ? 117.857 163.346 155.633 1.00 112.71 ? 482 ASN A ND2 1 
ATOM   2852 N N   . ARG A 1 452 ? 115.452 158.576 156.868 1.00 110.04 ? 483 ARG A N   1 
ATOM   2853 C CA  . ARG A 1 452 ? 114.852 158.186 158.136 1.00 109.86 ? 483 ARG A CA  1 
ATOM   2854 C C   . ARG A 1 452 ? 115.653 158.753 159.304 1.00 117.32 ? 483 ARG A C   1 
ATOM   2855 O O   . ARG A 1 452 ? 116.838 159.079 159.178 1.00 119.80 ? 483 ARG A O   1 
ATOM   2856 C CB  . ARG A 1 452 ? 114.746 156.664 158.254 1.00 102.05 ? 483 ARG A CB  1 
ATOM   2857 C CG  . ARG A 1 452 ? 114.140 155.969 157.038 1.00 102.31 ? 483 ARG A CG  1 
ATOM   2858 C CD  . ARG A 1 452 ? 113.734 154.539 157.373 1.00 103.24 ? 483 ARG A CD  1 
ATOM   2859 N NE  . ARG A 1 452 ? 112.753 154.523 158.454 1.00 110.16 ? 483 ARG A NE  1 
ATOM   2860 C CZ  . ARG A 1 452 ? 112.068 153.457 158.846 1.00 102.53 ? 483 ARG A CZ  1 
ATOM   2861 N NH1 . ARG A 1 452 ? 112.201 152.287 158.244 1.00 101.61 ? 483 ARG A NH1 1 
ATOM   2862 N NH2 . ARG A 1 452 ? 111.232 153.567 159.876 1.00 95.36  ? 483 ARG A NH2 1 
ATOM   2863 N N   . ASP A 1 453 ? 114.959 158.931 160.435 1.00 121.53 ? 484 ASP A N   1 
ATOM   2864 C CA  . ASP A 1 453 ? 115.404 159.450 161.730 1.00 124.22 ? 484 ASP A CA  1 
ATOM   2865 C C   . ASP A 1 453 ? 115.969 160.884 161.670 1.00 124.13 ? 484 ASP A C   1 
ATOM   2866 O O   . ASP A 1 453 ? 116.749 161.243 162.562 1.00 128.59 ? 484 ASP A O   1 
ATOM   2867 C CB  . ASP A 1 453 ? 116.430 158.538 162.441 1.00 125.75 ? 484 ASP A CB  1 
ATOM   2868 C CG  . ASP A 1 453 ? 115.826 157.217 162.897 1.00 126.21 ? 484 ASP A CG  1 
ATOM   2869 O OD1 . ASP A 1 453 ? 114.609 157.187 163.188 1.00 121.26 ? 484 ASP A OD1 1 
ATOM   2870 O OD2 . ASP A 1 453 ? 116.558 156.203 162.956 1.00 131.50 ? 484 ASP A OD2 1 
ATOM   2871 N N   . ASN A 1 454 ? 115.626 161.690 160.640 1.00 111.83 ? 485 ASN A N   1 
ATOM   2872 C CA  . ASN A 1 454 ? 115.789 163.147 160.509 1.00 108.21 ? 485 ASN A CA  1 
ATOM   2873 C C   . ASN A 1 454 ? 117.242 163.605 160.539 1.00 114.11 ? 485 ASN A C   1 
ATOM   2874 O O   . ASN A 1 454 ? 117.616 164.421 161.389 1.00 110.82 ? 485 ASN A O   1 
ATOM   2875 C CB  . ASN A 1 454 ? 115.007 163.896 161.593 1.00 104.63 ? 485 ASN A CB  1 
ATOM   2876 C CG  . ASN A 1 454 ? 113.526 163.714 161.462 1.00 98.68  ? 485 ASN A CG  1 
ATOM   2877 O OD1 . ASN A 1 454 ? 113.058 162.938 160.626 1.00 94.56  ? 485 ASN A OD1 1 
ATOM   2878 N ND2 . ASN A 1 454 ? 112.775 164.364 162.339 1.00 97.42  ? 485 ASN A ND2 1 
ATOM   2879 N N   . HIS A 1 455 ? 118.083 163.087 159.652 1.00 123.16 ? 486 HIS A N   1 
ATOM   2880 C CA  . HIS A 1 455 ? 119.459 163.558 159.605 1.00 130.76 ? 486 HIS A CA  1 
ATOM   2881 C C   . HIS A 1 455 ? 119.635 164.612 158.511 1.00 133.88 ? 486 HIS A C   1 
ATOM   2882 O O   . HIS A 1 455 ? 118.988 164.572 157.460 1.00 129.86 ? 486 HIS A O   1 
ATOM   2883 C CB  . HIS A 1 455 ? 120.414 162.387 159.388 1.00 124.80 ? 486 HIS A CB  1 
ATOM   2884 C CG  . HIS A 1 455 ? 120.315 161.330 160.444 1.00 126.94 ? 486 HIS A CG  1 
ATOM   2885 N ND1 . HIS A 1 455 ? 120.620 160.008 160.201 1.00 129.24 ? 486 HIS A ND1 1 
ATOM   2886 C CD2 . HIS A 1 455 ? 119.934 161.394 161.743 1.00 128.22 ? 486 HIS A CD2 1 
ATOM   2887 C CE1 . HIS A 1 455 ? 120.440 159.305 161.305 1.00 128.71 ? 486 HIS A CE1 1 
ATOM   2888 N NE2 . HIS A 1 455 ? 120.023 160.122 162.256 1.00 127.00 ? 486 HIS A NE2 1 
ATOM   2889 N N   . THR A 1 456 ? 120.523 165.569 158.772 1.00 135.16 ? 487 THR A N   1 
ATOM   2890 C CA  . THR A 1 456 ? 120.814 166.638 157.828 1.00 141.18 ? 487 THR A CA  1 
ATOM   2891 C C   . THR A 1 456 ? 121.990 166.302 156.918 1.00 144.17 ? 487 THR A C   1 
ATOM   2892 O O   . THR A 1 456 ? 122.327 167.093 156.031 1.00 142.30 ? 487 THR A O   1 
ATOM   2893 C CB  . THR A 1 456 ? 121.077 167.948 158.575 1.00 143.37 ? 487 THR A CB  1 
ATOM   2894 O OG1 . THR A 1 456 ? 122.415 167.949 159.090 1.00 144.80 ? 487 THR A OG1 1 
ATOM   2895 C CG2 . THR A 1 456 ? 120.086 168.125 159.723 1.00 136.74 ? 487 THR A CG2 1 
ATOM   2896 N N   . SER A 1 457 ? 122.611 165.141 157.113 1.00 141.92 ? 488 SER A N   1 
ATOM   2897 C CA  . SER A 1 457 ? 123.704 164.697 156.260 1.00 133.50 ? 488 SER A CA  1 
ATOM   2898 C C   . SER A 1 457 ? 123.705 163.176 156.230 1.00 126.11 ? 488 SER A C   1 
ATOM   2899 O O   . SER A 1 457 ? 123.339 162.516 157.206 1.00 124.69 ? 488 SER A O   1 
ATOM   2900 C CB  . SER A 1 457 ? 125.058 165.230 156.744 1.00 128.40 ? 488 SER A CB  1 
ATOM   2901 O OG  . SER A 1 457 ? 125.378 164.728 158.030 1.00 127.89 ? 488 SER A OG  1 
ATOM   2902 N N   . LEU A 1 458 ? 124.114 162.630 155.089 1.00 116.29 ? 489 LEU A N   1 
ATOM   2903 C CA  . LEU A 1 458 ? 124.168 161.192 154.878 1.00 105.51 ? 489 LEU A CA  1 
ATOM   2904 C C   . LEU A 1 458 ? 125.552 160.832 154.359 1.00 98.23  ? 489 LEU A C   1 
ATOM   2905 O O   . LEU A 1 458 ? 125.974 161.327 153.309 1.00 100.55 ? 489 LEU A O   1 
ATOM   2906 C CB  . LEU A 1 458 ? 123.061 160.747 153.909 1.00 103.15 ? 489 LEU A CB  1 
ATOM   2907 C CG  . LEU A 1 458 ? 122.693 159.278 153.653 1.00 96.08  ? 489 LEU A CG  1 
ATOM   2908 C CD1 . LEU A 1 458 ? 121.206 159.202 153.377 1.00 93.72  ? 489 LEU A CD1 1 
ATOM   2909 C CD2 . LEU A 1 458 ? 123.428 158.658 152.472 1.00 89.05  ? 489 LEU A CD2 1 
ATOM   2910 N N   . GLU A 1 459 ? 126.249 159.980 155.100 1.00 89.66  ? 490 GLU A N   1 
ATOM   2911 C CA  . GLU A 1 459 ? 127.535 159.432 154.689 1.00 80.18  ? 490 GLU A CA  1 
ATOM   2912 C C   . GLU A 1 459 ? 127.289 158.425 153.572 1.00 75.11  ? 490 GLU A C   1 
ATOM   2913 O O   . GLU A 1 459 ? 126.411 157.566 153.686 1.00 75.17  ? 490 GLU A O   1 
ATOM   2914 C CB  . GLU A 1 459 ? 128.226 158.782 155.885 1.00 87.56  ? 490 GLU A CB  1 
ATOM   2915 C CG  . GLU A 1 459 ? 129.570 158.137 155.604 1.00 90.07  ? 490 GLU A CG  1 
ATOM   2916 C CD  . GLU A 1 459 ? 130.199 157.549 156.857 1.00 93.50  ? 490 GLU A CD  1 
ATOM   2917 O OE1 . GLU A 1 459 ? 129.561 157.606 157.930 1.00 92.48  ? 490 GLU A OE1 1 
ATOM   2918 O OE2 . GLU A 1 459 ? 131.326 157.021 156.768 1.00 93.75  ? 490 GLU A OE2 1 
ATOM   2919 N N   . LEU A 1 460 ? 128.047 158.539 152.488 1.00 76.90  ? 491 LEU A N   1 
ATOM   2920 C CA  . LEU A 1 460 ? 127.867 157.642 151.356 1.00 74.89  ? 491 LEU A CA  1 
ATOM   2921 C C   . LEU A 1 460 ? 128.515 156.296 151.645 1.00 62.71  ? 491 LEU A C   1 
ATOM   2922 O O   . LEU A 1 460 ? 129.717 156.220 151.918 1.00 63.24  ? 491 LEU A O   1 
ATOM   2923 C CB  . LEU A 1 460 ? 128.466 158.255 150.089 1.00 76.99  ? 491 LEU A CB  1 
ATOM   2924 C CG  . LEU A 1 460 ? 127.786 159.463 149.434 1.00 75.70  ? 491 LEU A CG  1 
ATOM   2925 C CD1 . LEU A 1 460 ? 128.376 159.709 148.056 1.00 73.80  ? 491 LEU A CD1 1 
ATOM   2926 C CD2 . LEU A 1 460 ? 126.275 159.282 149.341 1.00 71.07  ? 491 LEU A CD2 1 
ATOM   2927 N N   . LYS A 1 461 ? 127.722 155.236 151.590 1.00 53.95  ? 492 LYS A N   1 
ATOM   2928 C CA  . LYS A 1 461 ? 128.219 153.892 151.827 1.00 49.58  ? 492 LYS A CA  1 
ATOM   2929 C C   . LYS A 1 461 ? 128.978 153.379 150.613 1.00 38.63  ? 492 LYS A C   1 
ATOM   2930 O O   . LYS A 1 461 ? 128.813 153.869 149.495 1.00 38.64  ? 492 LYS A O   1 
ATOM   2931 C CB  . LYS A 1 461 ? 127.078 152.930 152.170 1.00 52.50  ? 492 LYS A CB  1 
ATOM   2932 C CG  . LYS A 1 461 ? 126.376 153.224 153.480 1.00 46.21  ? 492 LYS A CG  1 
ATOM   2933 C CD  . LYS A 1 461 ? 125.385 152.133 153.813 1.00 44.53  ? 492 LYS A CD  1 
ATOM   2934 C CE  . LYS A 1 461 ? 124.608 152.469 155.071 1.00 57.31  ? 492 LYS A CE  1 
ATOM   2935 N NZ  . LYS A 1 461 ? 123.705 151.357 155.483 1.00 60.55  ? 492 LYS A NZ  1 
ATOM   2936 N N   . THR A 1 462 ? 129.831 152.391 150.861 1.00 33.70  ? 493 THR A N   1 
ATOM   2937 C CA  . THR A 1 462 ? 130.546 151.718 149.790 1.00 28.17  ? 493 THR A CA  1 
ATOM   2938 C C   . THR A 1 462 ? 129.595 150.824 149.015 1.00 24.86  ? 493 THR A C   1 
ATOM   2939 O O   . THR A 1 462 ? 128.650 150.269 149.575 1.00 28.12  ? 493 THR A O   1 
ATOM   2940 C CB  . THR A 1 462 ? 131.692 150.886 150.355 1.00 30.04  ? 493 THR A CB  1 
ATOM   2941 O OG1 . THR A 1 462 ? 131.158 149.786 151.099 1.00 34.61  ? 493 THR A OG1 1 
ATOM   2942 C CG2 . THR A 1 462 ? 132.552 151.733 151.278 1.00 30.58  ? 493 THR A CG2 1 
ATOM   2943 N N   . LYS A 1 463 ? 129.842 150.694 147.718 1.00 23.21  ? 494 LYS A N   1 
ATOM   2944 C CA  . LYS A 1 463 ? 128.928 149.963 146.862 1.00 20.74  ? 494 LYS A CA  1 
ATOM   2945 C C   . LYS A 1 463 ? 129.151 148.462 146.991 1.00 15.95  ? 494 LYS A C   1 
ATOM   2946 O O   . LYS A 1 463 ? 130.130 148.003 147.571 1.00 20.85  ? 494 LYS A O   1 
ATOM   2947 C CB  . LYS A 1 463 ? 129.089 150.414 145.414 1.00 20.47  ? 494 LYS A CB  1 
ATOM   2948 C CG  . LYS A 1 463 ? 128.899 151.908 145.250 1.00 22.03  ? 494 LYS A CG  1 
ATOM   2949 C CD  . LYS A 1 463 ? 128.968 152.336 143.805 1.00 33.53  ? 494 LYS A CD  1 
ATOM   2950 C CE  . LYS A 1 463 ? 128.338 153.706 143.624 1.00 38.93  ? 494 LYS A CE  1 
ATOM   2951 N NZ  . LYS A 1 463 ? 128.278 154.115 142.193 1.00 29.21  ? 494 LYS A NZ  1 
ATOM   2952 N N   . PHE A 1 464 ? 128.202 147.695 146.456 1.00 11.95  ? 495 PHE A N   1 
ATOM   2953 C CA  . PHE A 1 464 ? 128.273 146.237 146.514 1.00 12.80  ? 495 PHE A CA  1 
ATOM   2954 C C   . PHE A 1 464 ? 129.298 145.705 145.522 1.00 19.21  ? 495 PHE A C   1 
ATOM   2955 O O   . PHE A 1 464 ? 129.836 144.611 145.709 1.00 24.20  ? 495 PHE A O   1 
ATOM   2956 C CB  . PHE A 1 464 ? 126.860 145.687 146.268 1.00 11.81  ? 495 PHE A CB  1 
ATOM   2957 C CG  . PHE A 1 464 ? 126.711 144.177 146.174 1.00 10.79  ? 495 PHE A CG  1 
ATOM   2958 C CD1 . PHE A 1 464 ? 126.745 143.513 144.935 1.00 11.65  ? 495 PHE A CD1 1 
ATOM   2959 C CD2 . PHE A 1 464 ? 126.370 143.448 147.306 1.00 12.60  ? 495 PHE A CD2 1 
ATOM   2960 C CE1 . PHE A 1 464 ? 126.557 142.142 144.850 1.00 12.79  ? 495 PHE A CE1 1 
ATOM   2961 C CE2 . PHE A 1 464 ? 126.158 142.066 147.230 1.00 14.74  ? 495 PHE A CE2 1 
ATOM   2962 C CZ  . PHE A 1 464 ? 126.259 141.420 145.998 1.00 15.03  ? 495 PHE A CZ  1 
ATOM   2963 N N   . GLY A 1 465 ? 129.566 146.450 144.450 1.00 20.40  ? 496 GLY A N   1 
ATOM   2964 C CA  . GLY A 1 465 ? 130.528 145.982 143.465 1.00 18.58  ? 496 GLY A CA  1 
ATOM   2965 C C   . GLY A 1 465 ? 131.964 146.157 143.919 1.00 21.47  ? 496 GLY A C   1 
ATOM   2966 O O   . GLY A 1 465 ? 132.843 145.380 143.542 1.00 28.20  ? 496 GLY A O   1 
ATOM   2967 N N   . GLN A 1 466 ? 132.220 147.180 144.734 1.00 19.74  ? 497 GLN A N   1 
ATOM   2968 C CA  . GLN A 1 466 ? 133.568 147.390 145.249 1.00 20.63  ? 497 GLN A CA  1 
ATOM   2969 C C   . GLN A 1 466 ? 133.877 146.449 146.406 1.00 22.01  ? 497 GLN A C   1 
ATOM   2970 O O   . GLN A 1 466 ? 135.047 146.200 146.717 1.00 25.96  ? 497 GLN A O   1 
ATOM   2971 C CB  . GLN A 1 466 ? 133.751 148.844 145.671 1.00 20.83  ? 497 GLN A CB  1 
ATOM   2972 C CG  . GLN A 1 466 ? 133.551 149.830 144.542 1.00 26.57  ? 497 GLN A CG  1 
ATOM   2973 C CD  . GLN A 1 466 ? 133.567 151.267 145.015 1.00 33.70  ? 497 GLN A CD  1 
ATOM   2974 O OE1 . GLN A 1 466 ? 133.805 151.544 146.189 1.00 30.05  ? 497 GLN A OE1 1 
ATOM   2975 N NE2 . GLN A 1 466 ? 133.319 152.193 144.097 1.00 44.53  ? 497 GLN A NE2 1 
ATOM   2976 N N   . VAL A 1 467 ? 132.844 145.926 147.066 1.00 22.45  ? 498 VAL A N   1 
ATOM   2977 C CA  . VAL A 1 467 ? 133.066 144.927 148.105 1.00 21.53  ? 498 VAL A CA  1 
ATOM   2978 C C   . VAL A 1 467 ? 133.232 143.544 147.485 1.00 21.44  ? 498 VAL A C   1 
ATOM   2979 O O   . VAL A 1 467 ? 134.165 142.805 147.822 1.00 23.78  ? 498 VAL A O   1 
ATOM   2980 C CB  . VAL A 1 467 ? 131.920 144.983 149.137 1.00 18.40  ? 498 VAL A CB  1 
ATOM   2981 C CG1 . VAL A 1 467 ? 132.048 143.894 150.176 1.00 22.35  ? 498 VAL A CG1 1 
ATOM   2982 C CG2 . VAL A 1 467 ? 131.934 146.317 149.849 1.00 20.28  ? 498 VAL A CG2 1 
ATOM   2983 N N   . PHE A 1 468 ? 132.384 143.199 146.519 1.00 20.96  ? 499 PHE A N   1 
ATOM   2984 C CA  . PHE A 1 468 ? 132.289 141.833 146.016 1.00 24.69  ? 499 PHE A CA  1 
ATOM   2985 C C   . PHE A 1 468 ? 133.054 141.631 144.712 1.00 32.76  ? 499 PHE A C   1 
ATOM   2986 O O   . PHE A 1 468 ? 132.605 140.874 143.845 1.00 35.57  ? 499 PHE A O   1 
ATOM   2987 C CB  . PHE A 1 468 ? 130.829 141.415 145.824 1.00 17.78  ? 499 PHE A CB  1 
ATOM   2988 C CG  . PHE A 1 468 ? 130.121 141.028 147.095 1.00 19.09  ? 499 PHE A CG  1 
ATOM   2989 C CD1 . PHE A 1 468 ? 129.719 141.994 148.028 1.00 21.12  ? 499 PHE A CD1 1 
ATOM   2990 C CD2 . PHE A 1 468 ? 129.837 139.690 147.344 1.00 21.85  ? 499 PHE A CD2 1 
ATOM   2991 C CE1 . PHE A 1 468 ? 129.071 141.628 149.199 1.00 22.39  ? 499 PHE A CE1 1 
ATOM   2992 C CE2 . PHE A 1 468 ? 129.181 139.314 148.507 1.00 20.87  ? 499 PHE A CE2 1 
ATOM   2993 C CZ  . PHE A 1 468 ? 128.791 140.288 149.428 1.00 19.68  ? 499 PHE A CZ  1 
ATOM   2994 N N   . ASN A 1 469 ? 134.203 142.281 144.553 1.00 32.16  ? 500 ASN A N   1 
ATOM   2995 C CA  . ASN A 1 469 ? 135.037 142.071 143.375 1.00 31.13  ? 500 ASN A CA  1 
ATOM   2996 C C   . ASN A 1 469 ? 135.973 140.885 143.614 1.00 39.37  ? 500 ASN A C   1 
ATOM   2997 O O   . ASN A 1 469 ? 135.845 140.133 144.584 1.00 40.56  ? 500 ASN A O   1 
ATOM   2998 C CB  . ASN A 1 469 ? 135.798 143.345 143.017 1.00 26.37  ? 500 ASN A CB  1 
ATOM   2999 C CG  . ASN A 1 469 ? 136.411 144.038 144.224 1.00 30.67  ? 500 ASN A CG  1 
ATOM   3000 O OD1 . ASN A 1 469 ? 136.440 143.503 145.330 1.00 37.28  ? 500 ASN A OD1 1 
ATOM   3001 N ND2 . ASN A 1 469 ? 136.921 145.243 144.005 1.00 26.85  ? 500 ASN A ND2 1 
ATOM   3002 N N   . CYS A 1 470 ? 136.938 140.706 142.722 1.00 45.55  ? 501 CYS A N   1 
ATOM   3003 C CA  . CYS A 1 470 ? 137.898 139.621 142.873 1.00 49.03  ? 501 CYS A CA  1 
ATOM   3004 C C   . CYS A 1 470 ? 139.239 140.141 143.384 1.00 40.49  ? 501 CYS A C   1 
ATOM   3005 O O   . CYS A 1 470 ? 140.031 140.694 142.623 1.00 42.43  ? 501 CYS A O   1 
ATOM   3006 C CB  . CYS A 1 470 ? 138.084 138.890 141.548 1.00 52.35  ? 501 CYS A CB  1 
ATOM   3007 S SG  . CYS A 1 470 ? 136.543 138.324 140.799 1.00 70.98  ? 501 CYS A SG  1 
ATOM   3008 N N   . MET A 1 490 ? 137.903 127.196 141.638 1.00 66.94  ? 521 MET A N   1 
ATOM   3009 C CA  . MET A 1 490 ? 136.509 127.556 141.855 1.00 62.88  ? 521 MET A CA  1 
ATOM   3010 C C   . MET A 1 490 ? 135.603 126.375 141.552 1.00 59.58  ? 521 MET A C   1 
ATOM   3011 O O   . MET A 1 490 ? 135.529 125.918 140.415 1.00 58.87  ? 521 MET A O   1 
ATOM   3012 C CB  . MET A 1 490 ? 136.124 128.758 140.992 1.00 60.74  ? 521 MET A CB  1 
ATOM   3013 C CG  . MET A 1 490 ? 136.823 130.046 141.390 1.00 68.12  ? 521 MET A CG  1 
ATOM   3014 S SD  . MET A 1 490 ? 136.365 131.447 140.353 1.00 94.10  ? 521 MET A SD  1 
ATOM   3015 C CE  . MET A 1 490 ? 137.422 132.727 141.028 1.00 77.40  ? 521 MET A CE  1 
ATOM   3016 N N   . PHE A 1 491 ? 134.922 125.874 142.575 1.00 57.81  ? 522 PHE A N   1 
ATOM   3017 C CA  . PHE A 1 491 ? 134.026 124.745 142.380 1.00 54.53  ? 522 PHE A CA  1 
ATOM   3018 C C   . PHE A 1 491 ? 132.625 125.062 142.889 1.00 54.52  ? 522 PHE A C   1 
ATOM   3019 O O   . PHE A 1 491 ? 132.445 125.798 143.860 1.00 58.89  ? 522 PHE A O   1 
ATOM   3020 C CB  . PHE A 1 491 ? 134.594 123.473 143.033 1.00 54.12  ? 522 PHE A CB  1 
ATOM   3021 C CG  . PHE A 1 491 ? 134.630 123.471 144.547 1.00 50.99  ? 522 PHE A CG  1 
ATOM   3022 C CD1 . PHE A 1 491 ? 135.691 124.065 145.235 1.00 49.56  ? 522 PHE A CD1 1 
ATOM   3023 C CD2 . PHE A 1 491 ? 133.654 122.784 145.276 1.00 52.61  ? 522 PHE A CD2 1 
ATOM   3024 C CE1 . PHE A 1 491 ? 135.745 124.038 146.624 1.00 50.30  ? 522 PHE A CE1 1 
ATOM   3025 C CE2 . PHE A 1 491 ? 133.695 122.753 146.666 1.00 53.03  ? 522 PHE A CE2 1 
ATOM   3026 C CZ  . PHE A 1 491 ? 134.746 123.380 147.337 1.00 51.66  ? 522 PHE A CZ  1 
ATOM   3027 N N   . TRP A 1 492 ? 131.633 124.482 142.225 1.00 53.12  ? 523 TRP A N   1 
ATOM   3028 C CA  . TRP A 1 492 ? 130.222 124.755 142.452 1.00 53.39  ? 523 TRP A CA  1 
ATOM   3029 C C   . TRP A 1 492 ? 129.584 123.600 143.208 1.00 54.41  ? 523 TRP A C   1 
ATOM   3030 O O   . TRP A 1 492 ? 129.665 122.456 142.760 1.00 57.29  ? 523 TRP A O   1 
ATOM   3031 C CB  . TRP A 1 492 ? 129.512 124.945 141.110 1.00 50.74  ? 523 TRP A CB  1 
ATOM   3032 C CG  . TRP A 1 492 ? 129.767 126.243 140.407 1.00 53.07  ? 523 TRP A CG  1 
ATOM   3033 C CD1 . TRP A 1 492 ? 129.078 127.402 140.576 1.00 57.24  ? 523 TRP A CD1 1 
ATOM   3034 C CD2 . TRP A 1 492 ? 130.818 126.538 139.480 1.00 53.93  ? 523 TRP A CD2 1 
ATOM   3035 N NE1 . TRP A 1 492 ? 129.579 128.381 139.765 1.00 58.90  ? 523 TRP A NE1 1 
ATOM   3036 C CE2 . TRP A 1 492 ? 130.664 127.886 139.096 1.00 59.37  ? 523 TRP A CE2 1 
ATOM   3037 C CE3 . TRP A 1 492 ? 131.855 125.790 138.916 1.00 52.74  ? 523 TRP A CE3 1 
ATOM   3038 C CZ2 . TRP A 1 492 ? 131.515 128.506 138.182 1.00 60.67  ? 523 TRP A CZ2 1 
ATOM   3039 C CZ3 . TRP A 1 492 ? 132.702 126.411 138.005 1.00 54.63  ? 523 TRP A CZ3 1 
ATOM   3040 C CH2 . TRP A 1 492 ? 132.525 127.753 137.650 1.00 58.08  ? 523 TRP A CH2 1 
ATOM   3041 N N   . ARG A 1 493 ? 128.929 123.896 144.328 1.00 49.82  ? 524 ARG A N   1 
ATOM   3042 C CA  . ARG A 1 493 ? 128.192 122.898 145.098 1.00 47.47  ? 524 ARG A CA  1 
ATOM   3043 C C   . ARG A 1 493 ? 126.699 123.113 144.884 1.00 47.38  ? 524 ARG A C   1 
ATOM   3044 O O   . ARG A 1 493 ? 126.170 124.167 145.242 1.00 53.11  ? 524 ARG A O   1 
ATOM   3045 C CB  . ARG A 1 493 ? 128.531 122.994 146.583 1.00 48.24  ? 524 ARG A CB  1 
ATOM   3046 C CG  . ARG A 1 493 ? 130.005 123.134 146.884 1.00 50.56  ? 524 ARG A CG  1 
ATOM   3047 C CD  . ARG A 1 493 ? 130.223 123.410 148.355 1.00 55.65  ? 524 ARG A CD  1 
ATOM   3048 N NE  . ARG A 1 493 ? 129.788 122.290 149.179 1.00 59.45  ? 524 ARG A NE  1 
ATOM   3049 C CZ  . ARG A 1 493 ? 129.889 122.247 150.499 1.00 59.91  ? 524 ARG A CZ  1 
ATOM   3050 N NH1 . ARG A 1 493 ? 130.400 123.253 151.186 1.00 62.79  ? 524 ARG A NH1 1 
ATOM   3051 N NH2 . ARG A 1 493 ? 129.465 121.167 151.147 1.00 58.56  ? 524 ARG A NH2 1 
ATOM   3052 N N   . ILE A 1 494 ? 126.016 122.114 144.331 1.00 41.54  ? 525 ILE A N   1 
ATOM   3053 C CA  . ILE A 1 494 ? 124.659 122.289 143.821 1.00 41.31  ? 525 ILE A CA  1 
ATOM   3054 C C   . ILE A 1 494 ? 123.726 121.361 144.591 1.00 43.89  ? 525 ILE A C   1 
ATOM   3055 O O   . ILE A 1 494 ? 123.945 120.145 144.625 1.00 46.74  ? 525 ILE A O   1 
ATOM   3056 C CB  . ILE A 1 494 ? 124.558 122.014 142.309 1.00 42.94  ? 525 ILE A CB  1 
ATOM   3057 C CG1 . ILE A 1 494 ? 125.484 122.900 141.473 1.00 45.29  ? 525 ILE A CG1 1 
ATOM   3058 C CG2 . ILE A 1 494 ? 123.190 122.338 141.821 1.00 42.72  ? 525 ILE A CG2 1 
ATOM   3059 C CD1 . ILE A 1 494 ? 126.768 122.258 141.001 1.00 45.60  ? 525 ILE A CD1 1 
ATOM   3060 N N   . LYS A 1 495 ? 122.678 121.926 145.190 1.00 43.75  ? 526 LYS A N   1 
ATOM   3061 C CA  . LYS A 1 495 ? 121.682 121.169 145.936 1.00 44.47  ? 526 LYS A CA  1 
ATOM   3062 C C   . LYS A 1 495 ? 120.321 121.301 145.267 1.00 46.33  ? 526 LYS A C   1 
ATOM   3063 O O   . LYS A 1 495 ? 119.783 122.406 145.170 1.00 44.84  ? 526 LYS A O   1 
ATOM   3064 C CB  . LYS A 1 495 ? 121.592 121.667 147.375 1.00 42.22  ? 526 LYS A CB  1 
ATOM   3065 C CG  . LYS A 1 495 ? 122.915 121.678 148.092 1.00 41.55  ? 526 LYS A CG  1 
ATOM   3066 C CD  . LYS A 1 495 ? 122.799 122.246 149.486 1.00 42.21  ? 526 LYS A CD  1 
ATOM   3067 C CE  . LYS A 1 495 ? 122.759 123.755 149.456 1.00 40.84  ? 526 LYS A CE  1 
ATOM   3068 N NZ  . LYS A 1 495 ? 122.843 124.329 150.825 1.00 37.98  ? 526 LYS A NZ  1 
ATOM   3069 N N   . MET A 1 496 ? 119.760 120.179 144.825 1.00 48.79  ? 527 MET A N   1 
ATOM   3070 C CA  . MET A 1 496 ? 118.396 120.119 144.314 1.00 45.43  ? 527 MET A CA  1 
ATOM   3071 C C   . MET A 1 496 ? 117.426 120.031 145.477 1.00 46.99  ? 527 MET A C   1 
ATOM   3072 O O   . MET A 1 496 ? 117.501 119.098 146.282 1.00 53.66  ? 527 MET A O   1 
ATOM   3073 C CB  . MET A 1 496 ? 118.207 118.934 143.372 1.00 50.46  ? 527 MET A CB  1 
ATOM   3074 C CG  . MET A 1 496 ? 117.366 119.257 142.165 1.00 54.17  ? 527 MET A CG  1 
ATOM   3075 S SD  . MET A 1 496 ? 117.257 117.914 140.970 1.00 76.70  ? 527 MET A SD  1 
ATOM   3076 C CE  . MET A 1 496 ? 116.077 116.822 141.738 1.00 57.19  ? 527 MET A CE  1 
ATOM   3077 N N   . ASP A 1 497 ? 116.510 120.985 145.550 1.00 44.71  ? 528 ASP A N   1 
ATOM   3078 C CA  . ASP A 1 497 ? 115.576 121.088 146.655 1.00 47.23  ? 528 ASP A CA  1 
ATOM   3079 C C   . ASP A 1 497 ? 114.174 121.317 146.114 1.00 51.91  ? 528 ASP A C   1 
ATOM   3080 O O   . ASP A 1 497 ? 113.996 121.732 144.966 1.00 55.86  ? 528 ASP A O   1 
ATOM   3081 C CB  . ASP A 1 497 ? 115.981 122.224 147.603 1.00 49.62  ? 528 ASP A CB  1 
ATOM   3082 C CG  . ASP A 1 497 ? 115.508 121.999 149.023 1.00 51.94  ? 528 ASP A CG  1 
ATOM   3083 O OD1 . ASP A 1 497 ? 114.832 120.980 149.269 1.00 50.91  ? 528 ASP A OD1 1 
ATOM   3084 O OD2 . ASP A 1 497 ? 115.822 122.833 149.897 1.00 52.74  ? 528 ASP A OD2 1 
ATOM   3085 N N   . THR A 1 498 ? 113.178 121.012 146.936 1.00 51.56  ? 529 THR A N   1 
ATOM   3086 C CA  . THR A 1 498 ? 111.791 121.321 146.607 1.00 51.40  ? 529 THR A CA  1 
ATOM   3087 C C   . THR A 1 498 ? 111.034 121.720 147.866 1.00 49.48  ? 529 THR A C   1 
ATOM   3088 O O   . THR A 1 498 ? 111.189 121.097 148.916 1.00 50.84  ? 529 THR A O   1 
ATOM   3089 C CB  . THR A 1 498 ? 111.072 120.138 145.951 1.00 49.78  ? 529 THR A CB  1 
ATOM   3090 O OG1 . THR A 1 498 ? 111.738 119.775 144.738 1.00 46.88  ? 529 THR A OG1 1 
ATOM   3091 C CG2 . THR A 1 498 ? 109.644 120.507 145.628 1.00 51.75  ? 529 THR A CG2 1 
ATOM   3092 N N   . VAL B 1 77  ? 163.574 124.758 103.296 1.00 33.52  ? 108 VAL B N   1 
ATOM   3093 C CA  . VAL B 1 77  ? 162.844 124.186 104.415 1.00 34.43  ? 108 VAL B CA  1 
ATOM   3094 C C   . VAL B 1 77  ? 162.880 125.193 105.578 1.00 43.99  ? 108 VAL B C   1 
ATOM   3095 O O   . VAL B 1 77  ? 163.962 125.652 105.946 1.00 51.80  ? 108 VAL B O   1 
ATOM   3096 C CB  . VAL B 1 77  ? 163.435 122.827 104.806 1.00 40.32  ? 108 VAL B CB  1 
ATOM   3097 C CG1 . VAL B 1 77  ? 162.731 122.254 106.015 1.00 48.10  ? 108 VAL B CG1 1 
ATOM   3098 C CG2 . VAL B 1 77  ? 163.363 121.867 103.636 1.00 41.50  ? 108 VAL B CG2 1 
ATOM   3099 N N   . PRO B 1 78  ? 161.719 125.553 106.140 1.00 48.06  ? 109 PRO B N   1 
ATOM   3100 C CA  . PRO B 1 78  ? 161.685 126.629 107.144 1.00 48.04  ? 109 PRO B CA  1 
ATOM   3101 C C   . PRO B 1 78  ? 162.174 126.194 108.521 1.00 41.47  ? 109 PRO B C   1 
ATOM   3102 O O   . PRO B 1 78  ? 162.597 125.058 108.741 1.00 40.03  ? 109 PRO B O   1 
ATOM   3103 C CB  . PRO B 1 78  ? 160.202 127.020 107.195 1.00 46.64  ? 109 PRO B CB  1 
ATOM   3104 C CG  . PRO B 1 78  ? 159.616 126.491 105.918 1.00 47.95  ? 109 PRO B CG  1 
ATOM   3105 C CD  . PRO B 1 78  ? 160.357 125.213 105.690 1.00 43.14  ? 109 PRO B CD  1 
ATOM   3106 N N   . GLU B 1 79  ? 162.087 127.142 109.461 1.00 36.73  ? 110 GLU B N   1 
ATOM   3107 C CA  . GLU B 1 79  ? 162.668 126.967 110.793 1.00 34.77  ? 110 GLU B CA  1 
ATOM   3108 C C   . GLU B 1 79  ? 161.818 126.045 111.664 1.00 32.52  ? 110 GLU B C   1 
ATOM   3109 O O   . GLU B 1 79  ? 162.346 125.328 112.528 1.00 31.60  ? 110 GLU B O   1 
ATOM   3110 C CB  . GLU B 1 79  ? 162.828 128.338 111.456 1.00 34.50  ? 110 GLU B CB  1 
ATOM   3111 C CG  . GLU B 1 79  ? 163.716 128.376 112.687 1.00 36.55  ? 110 GLU B CG  1 
ATOM   3112 C CD  . GLU B 1 79  ? 163.575 129.672 113.465 1.00 40.76  ? 110 GLU B CD  1 
ATOM   3113 O OE1 . GLU B 1 79  ? 162.816 130.558 113.018 1.00 40.77  ? 110 GLU B OE1 1 
ATOM   3114 O OE2 . GLU B 1 79  ? 164.219 129.801 114.528 1.00 36.41  ? 110 GLU B OE2 1 
ATOM   3115 N N   . ILE B 1 80  ? 160.502 126.021 111.423 1.00 31.87  ? 111 ILE B N   1 
ATOM   3116 C CA  . ILE B 1 80  ? 159.580 125.280 112.283 1.00 29.17  ? 111 ILE B CA  1 
ATOM   3117 C C   . ILE B 1 80  ? 159.639 123.779 111.970 1.00 29.89  ? 111 ILE B C   1 
ATOM   3118 O O   . ILE B 1 80  ? 159.310 122.937 112.813 1.00 31.71  ? 111 ILE B O   1 
ATOM   3119 C CB  . ILE B 1 80  ? 158.159 125.888 112.156 1.00 27.28  ? 111 ILE B CB  1 
ATOM   3120 C CG1 . ILE B 1 80  ? 157.206 125.442 113.276 1.00 26.39  ? 111 ILE B CG1 1 
ATOM   3121 C CG2 . ILE B 1 80  ? 157.534 125.646 110.783 1.00 31.24  ? 111 ILE B CG2 1 
ATOM   3122 C CD1 . ILE B 1 80  ? 155.938 126.243 113.351 1.00 27.18  ? 111 ILE B CD1 1 
ATOM   3123 N N   . CYS B 1 81  ? 160.135 123.415 110.784 1.00 28.06  ? 112 CYS B N   1 
ATOM   3124 C CA  . CYS B 1 81  ? 160.358 122.006 110.487 1.00 29.35  ? 112 CYS B CA  1 
ATOM   3125 C C   . CYS B 1 81  ? 161.631 121.493 111.151 1.00 30.46  ? 112 CYS B C   1 
ATOM   3126 O O   . CYS B 1 81  ? 161.699 120.327 111.557 1.00 29.34  ? 112 CYS B O   1 
ATOM   3127 C CB  . CYS B 1 81  ? 160.414 121.795 108.977 1.00 30.63  ? 112 CYS B CB  1 
ATOM   3128 S SG  . CYS B 1 81  ? 159.095 122.630 108.083 1.00 28.59  ? 112 CYS B SG  1 
ATOM   3129 N N   . LEU B 1 82  ? 162.655 122.345 111.260 1.00 30.52  ? 113 LEU B N   1 
ATOM   3130 C CA  . LEU B 1 82  ? 163.904 121.921 111.889 1.00 30.73  ? 113 LEU B CA  1 
ATOM   3131 C C   . LEU B 1 82  ? 163.794 121.885 113.408 1.00 33.22  ? 113 LEU B C   1 
ATOM   3132 O O   . LEU B 1 82  ? 164.301 120.955 114.044 1.00 39.63  ? 113 LEU B O   1 
ATOM   3133 C CB  . LEU B 1 82  ? 165.066 122.825 111.466 1.00 31.03  ? 113 LEU B CB  1 
ATOM   3134 C CG  . LEU B 1 82  ? 165.877 122.543 110.193 1.00 33.62  ? 113 LEU B CG  1 
ATOM   3135 C CD1 . LEU B 1 82  ? 165.140 122.848 108.906 1.00 29.97  ? 113 LEU B CD1 1 
ATOM   3136 C CD2 . LEU B 1 82  ? 167.196 123.305 110.236 1.00 32.47  ? 113 LEU B CD2 1 
ATOM   3137 N N   . ASN B 1 83  ? 163.147 122.881 114.015 1.00 30.04  ? 114 ASN B N   1 
ATOM   3138 C CA  . ASN B 1 83  ? 163.091 122.957 115.470 1.00 25.87  ? 114 ASN B CA  1 
ATOM   3139 C C   . ASN B 1 83  ? 161.858 122.290 116.066 1.00 23.87  ? 114 ASN B C   1 
ATOM   3140 O O   . ASN B 1 83  ? 161.933 121.755 117.175 1.00 19.89  ? 114 ASN B O   1 
ATOM   3141 C CB  . ASN B 1 83  ? 163.169 124.411 115.930 1.00 29.79  ? 114 ASN B CB  1 
ATOM   3142 C CG  . ASN B 1 83  ? 164.542 125.007 115.729 1.00 34.41  ? 114 ASN B CG  1 
ATOM   3143 O OD1 . ASN B 1 83  ? 165.555 124.359 115.991 1.00 32.17  ? 114 ASN B OD1 1 
ATOM   3144 N ND2 . ASN B 1 83  ? 164.587 126.252 115.276 1.00 37.30  ? 114 ASN B ND2 1 
ATOM   3145 N N   . GLY B 1 84  ? 160.737 122.292 115.358 1.00 27.07  ? 115 GLY B N   1 
ATOM   3146 C CA  . GLY B 1 84  ? 159.545 121.667 115.904 1.00 27.82  ? 115 GLY B CA  1 
ATOM   3147 C C   . GLY B 1 84  ? 158.703 122.648 116.681 1.00 30.33  ? 115 GLY B C   1 
ATOM   3148 O O   . GLY B 1 84  ? 158.624 123.834 116.346 1.00 31.52  ? 115 GLY B O   1 
ATOM   3149 N N   . LEU B 1 85  ? 158.059 122.157 117.733 1.00 32.30  ? 116 LEU B N   1 
ATOM   3150 C CA  . LEU B 1 85  ? 157.181 122.964 118.568 1.00 39.21  ? 116 LEU B CA  1 
ATOM   3151 C C   . LEU B 1 85  ? 157.909 123.363 119.845 1.00 42.03  ? 116 LEU B C   1 
ATOM   3152 O O   . LEU B 1 85  ? 158.593 122.542 120.464 1.00 51.90  ? 116 LEU B O   1 
ATOM   3153 C CB  . LEU B 1 85  ? 155.896 122.207 118.916 1.00 37.80  ? 116 LEU B CB  1 
ATOM   3154 C CG  . LEU B 1 85  ? 155.018 121.631 117.804 1.00 36.74  ? 116 LEU B CG  1 
ATOM   3155 C CD1 . LEU B 1 85  ? 153.673 121.221 118.373 1.00 38.63  ? 116 LEU B CD1 1 
ATOM   3156 C CD2 . LEU B 1 85  ? 154.815 122.622 116.677 1.00 35.03  ? 116 LEU B CD2 1 
ATOM   3157 N N   . GLN B 1 86  ? 157.766 124.626 120.235 1.00 32.45  ? 117 GLN B N   1 
ATOM   3158 C CA  . GLN B 1 86  ? 158.459 125.175 121.389 1.00 35.04  ? 117 GLN B CA  1 
ATOM   3159 C C   . GLN B 1 86  ? 157.456 125.864 122.301 1.00 43.04  ? 117 GLN B C   1 
ATOM   3160 O O   . GLN B 1 86  ? 156.488 126.461 121.819 1.00 45.85  ? 117 GLN B O   1 
ATOM   3161 C CB  . GLN B 1 86  ? 159.545 126.158 120.952 1.00 31.47  ? 117 GLN B CB  1 
ATOM   3162 C CG  . GLN B 1 86  ? 160.765 125.499 120.347 1.00 28.77  ? 117 GLN B CG  1 
ATOM   3163 C CD  . GLN B 1 86  ? 161.416 126.352 119.286 1.00 28.88  ? 117 GLN B CD  1 
ATOM   3164 O OE1 . GLN B 1 86  ? 160.736 127.020 118.508 1.00 29.82  ? 117 GLN B OE1 1 
ATOM   3165 N NE2 . GLN B 1 86  ? 162.741 126.342 119.250 1.00 29.35  ? 117 GLN B NE2 1 
ATOM   3166 N N   . LEU B 1 87  ? 157.679 125.770 123.613 1.00 46.94  ? 118 LEU B N   1 
ATOM   3167 C CA  . LEU B 1 87  ? 156.823 126.413 124.606 1.00 53.09  ? 118 LEU B CA  1 
ATOM   3168 C C   . LEU B 1 87  ? 157.647 127.242 125.575 1.00 56.76  ? 118 LEU B C   1 
ATOM   3169 O O   . LEU B 1 87  ? 158.726 126.819 126.003 1.00 57.65  ? 118 LEU B O   1 
ATOM   3170 C CB  . LEU B 1 87  ? 155.989 125.395 125.387 1.00 52.56  ? 118 LEU B CB  1 
ATOM   3171 C CG  . LEU B 1 87  ? 154.931 124.627 124.610 1.00 48.07  ? 118 LEU B CG  1 
ATOM   3172 C CD1 . LEU B 1 87  ? 154.288 123.569 125.486 1.00 44.11  ? 118 LEU B CD1 1 
ATOM   3173 C CD2 . LEU B 1 87  ? 153.910 125.636 124.135 1.00 51.78  ? 118 LEU B CD2 1 
ATOM   3174 N N   . THR B 1 88  ? 157.126 128.418 125.920 1.00 58.04  ? 119 THR B N   1 
ATOM   3175 C CA  . THR B 1 88  ? 157.639 129.224 127.020 1.00 59.12  ? 119 THR B CA  1 
ATOM   3176 C C   . THR B 1 88  ? 156.679 129.060 128.193 1.00 57.63  ? 119 THR B C   1 
ATOM   3177 O O   . THR B 1 88  ? 155.586 129.635 128.193 1.00 57.97  ? 119 THR B O   1 
ATOM   3178 C CB  . THR B 1 88  ? 157.756 130.690 126.609 1.00 59.68  ? 119 THR B CB  1 
ATOM   3179 O OG1 . THR B 1 88  ? 156.548 131.104 125.958 1.00 56.12  ? 119 THR B OG1 1 
ATOM   3180 C CG2 . THR B 1 88  ? 158.919 130.886 125.653 1.00 55.05  ? 119 THR B CG2 1 
ATOM   3181 N N   . VAL B 1 89  ? 157.079 128.273 129.186 1.00 58.68  ? 120 VAL B N   1 
ATOM   3182 C CA  . VAL B 1 89  ? 156.201 127.979 130.313 1.00 62.91  ? 120 VAL B CA  1 
ATOM   3183 C C   . VAL B 1 89  ? 156.578 128.827 131.518 1.00 58.62  ? 120 VAL B C   1 
ATOM   3184 O O   . VAL B 1 89  ? 157.541 128.527 132.222 1.00 57.37  ? 120 VAL B O   1 
ATOM   3185 C CB  . VAL B 1 89  ? 156.237 126.483 130.671 1.00 63.80  ? 120 VAL B CB  1 
ATOM   3186 C CG1 . VAL B 1 89  ? 155.156 126.154 131.688 1.00 62.31  ? 120 VAL B CG1 1 
ATOM   3187 C CG2 . VAL B 1 89  ? 156.073 125.635 129.421 1.00 59.13  ? 120 VAL B CG2 1 
ATOM   3188 N N   . THR B 1 96  ? 159.282 130.197 132.799 1.00 138.41 ? 127 THR B N   1 
ATOM   3189 C CA  . THR B 1 96  ? 160.052 130.801 131.719 1.00 141.18 ? 127 THR B CA  1 
ATOM   3190 C C   . THR B 1 96  ? 161.103 129.822 131.203 1.00 139.56 ? 127 THR B C   1 
ATOM   3191 O O   . THR B 1 96  ? 162.261 130.186 130.991 1.00 137.87 ? 127 THR B O   1 
ATOM   3192 C CB  . THR B 1 96  ? 160.732 132.100 132.178 1.00 141.94 ? 127 THR B CB  1 
ATOM   3193 O OG1 . THR B 1 96  ? 161.496 131.846 133.364 1.00 143.29 ? 127 THR B OG1 1 
ATOM   3194 C CG2 . THR B 1 96  ? 159.689 133.166 132.473 1.00 139.17 ? 127 THR B CG2 1 
ATOM   3195 N N   . VAL B 1 97  ? 160.681 128.578 130.996 1.00 137.48 ? 128 VAL B N   1 
ATOM   3196 C CA  . VAL B 1 97  ? 161.560 127.487 130.589 1.00 133.27 ? 128 VAL B CA  1 
ATOM   3197 C C   . VAL B 1 97  ? 161.255 127.163 129.133 1.00 129.93 ? 128 VAL B C   1 
ATOM   3198 O O   . VAL B 1 97  ? 160.086 127.009 128.757 1.00 128.70 ? 128 VAL B O   1 
ATOM   3199 C CB  . VAL B 1 97  ? 161.371 126.251 131.486 1.00 132.51 ? 128 VAL B CB  1 
ATOM   3200 C CG1 . VAL B 1 97  ? 162.426 125.188 131.195 1.00 129.80 ? 128 VAL B CG1 1 
ATOM   3201 C CG2 . VAL B 1 97  ? 161.399 126.648 132.956 1.00 130.74 ? 128 VAL B CG2 1 
ATOM   3202 N N   . ILE B 1 98  ? 162.301 127.080 128.307 1.00 126.55 ? 129 ILE B N   1 
ATOM   3203 C CA  . ILE B 1 98  ? 162.120 126.654 126.926 1.00 123.08 ? 129 ILE B CA  1 
ATOM   3204 C C   . ILE B 1 98  ? 161.914 125.147 126.892 1.00 119.03 ? 129 ILE B C   1 
ATOM   3205 O O   . ILE B 1 98  ? 162.844 124.368 127.136 1.00 119.41 ? 129 ILE B O   1 
ATOM   3206 C CB  . ILE B 1 98  ? 163.327 127.071 126.071 1.00 120.51 ? 129 ILE B CB  1 
ATOM   3207 C CG1 . ILE B 1 98  ? 163.568 128.579 126.171 1.00 120.14 ? 129 ILE B CG1 1 
ATOM   3208 C CG2 . ILE B 1 98  ? 163.130 126.645 124.619 1.00 115.90 ? 129 ILE B CG2 1 
ATOM   3209 C CD1 . ILE B 1 98  ? 162.443 129.426 125.622 1.00 117.88 ? 129 ILE B CD1 1 
ATOM   3210 N N   . ARG B 1 99  ? 160.689 124.728 126.589 1.00 113.71 ? 130 ARG B N   1 
ATOM   3211 C CA  . ARG B 1 99  ? 160.341 123.318 126.512 1.00 111.67 ? 130 ARG B CA  1 
ATOM   3212 C C   . ARG B 1 99  ? 160.387 122.884 125.055 1.00 111.36 ? 130 ARG B C   1 
ATOM   3213 O O   . ARG B 1 99  ? 159.711 123.473 124.207 1.00 110.93 ? 130 ARG B O   1 
ATOM   3214 C CB  . ARG B 1 99  ? 158.958 123.051 127.116 1.00 108.90 ? 130 ARG B CB  1 
ATOM   3215 C CG  . ARG B 1 99  ? 158.566 121.584 127.119 1.00 105.08 ? 130 ARG B CG  1 
ATOM   3216 C CD  . ARG B 1 99  ? 157.239 121.344 127.814 1.00 101.51 ? 130 ARG B CD  1 
ATOM   3217 N NE  . ARG B 1 99  ? 157.307 121.579 129.250 1.00 102.66 ? 130 ARG B NE  1 
ATOM   3218 C CZ  . ARG B 1 99  ? 156.251 121.603 130.052 1.00 104.49 ? 130 ARG B CZ  1 
ATOM   3219 N NH1 . ARG B 1 99  ? 155.027 121.418 129.588 1.00 102.56 ? 130 ARG B NH1 1 
ATOM   3220 N NH2 . ARG B 1 99  ? 156.429 121.816 131.353 1.00 103.11 ? 130 ARG B NH2 1 
ATOM   3221 N N   . LYS B 1 100 ? 161.183 121.858 124.771 1.00 109.03 ? 131 LYS B N   1 
ATOM   3222 C CA  . LYS B 1 100 ? 161.447 121.450 123.400 1.00 104.93 ? 131 LYS B CA  1 
ATOM   3223 C C   . LYS B 1 100 ? 160.370 120.481 122.917 1.00 100.75 ? 131 LYS B C   1 
ATOM   3224 O O   . LYS B 1 100 ? 159.423 120.162 123.637 1.00 96.06  ? 131 LYS B O   1 
ATOM   3225 C CB  . LYS B 1 100 ? 162.836 120.797 123.230 1.00 103.70 ? 131 LYS B CB  1 
ATOM   3226 C CG  . LYS B 1 100 ? 164.144 121.641 123.438 1.00 108.79 ? 131 LYS B CG  1 
ATOM   3227 C CD  . LYS B 1 100 ? 164.543 122.032 124.877 1.00 112.14 ? 131 LYS B CD  1 
ATOM   3228 C CE  . LYS B 1 100 ? 165.478 123.225 124.905 1.00 112.70 ? 131 LYS B CE  1 
ATOM   3229 N NZ  . LYS B 1 100 ? 165.706 123.683 126.301 1.00 111.48 ? 131 LYS B NZ  1 
ATOM   3230 N N   . GLN B 1 101 ? 160.554 119.996 121.682 1.00 101.67 ? 132 GLN B N   1 
ATOM   3231 C CA  . GLN B 1 101 ? 159.536 119.194 121.001 1.00 97.01  ? 132 GLN B CA  1 
ATOM   3232 C C   . GLN B 1 101 ? 159.445 117.779 121.570 1.00 95.46  ? 132 GLN B C   1 
ATOM   3233 O O   . GLN B 1 101 ? 158.359 117.187 121.618 1.00 91.70  ? 132 GLN B O   1 
ATOM   3234 C CB  . GLN B 1 101 ? 159.850 119.142 119.504 1.00 91.64  ? 132 GLN B CB  1 
ATOM   3235 C CG  . GLN B 1 101 ? 158.747 118.583 118.623 1.00 86.11  ? 132 GLN B CG  1 
ATOM   3236 C CD  . GLN B 1 101 ? 159.217 118.346 117.211 1.00 88.76  ? 132 GLN B CD  1 
ATOM   3237 O OE1 . GLN B 1 101 ? 160.399 118.501 116.906 1.00 93.04  ? 132 GLN B OE1 1 
ATOM   3238 N NE2 . GLN B 1 101 ? 158.299 117.962 116.339 1.00 83.09  ? 132 GLN B NE2 1 
ATOM   3239 N N   . GLU B 1 102 ? 160.563 117.241 122.063 1.00 94.20  ? 133 GLU B N   1 
ATOM   3240 C CA  . GLU B 1 102 ? 160.585 115.843 122.487 1.00 88.95  ? 133 GLU B CA  1 
ATOM   3241 C C   . GLU B 1 102 ? 160.006 115.652 123.884 1.00 86.93  ? 133 GLU B C   1 
ATOM   3242 O O   . GLU B 1 102 ? 159.802 114.511 124.315 1.00 83.94  ? 133 GLU B O   1 
ATOM   3243 C CB  . GLU B 1 102 ? 162.017 115.291 122.430 1.00 90.04  ? 133 GLU B CB  1 
ATOM   3244 C CG  . GLU B 1 102 ? 162.572 114.841 121.046 1.00 93.69  ? 133 GLU B CG  1 
ATOM   3245 C CD  . GLU B 1 102 ? 162.613 115.903 119.935 1.00 93.55  ? 133 GLU B CD  1 
ATOM   3246 O OE1 . GLU B 1 102 ? 162.648 115.500 118.753 1.00 95.97  ? 133 GLU B OE1 1 
ATOM   3247 O OE2 . GLU B 1 102 ? 162.688 117.120 120.219 1.00 89.29  ? 133 GLU B OE2 1 
ATOM   3248 N N   . GLU B 1 103 ? 159.752 116.742 124.613 1.00 89.30  ? 134 GLU B N   1 
ATOM   3249 C CA  . GLU B 1 103 ? 159.195 116.621 125.954 1.00 89.68  ? 134 GLU B CA  1 
ATOM   3250 C C   . GLU B 1 103 ? 157.702 116.310 125.928 1.00 84.29  ? 134 GLU B C   1 
ATOM   3251 O O   . GLU B 1 103 ? 157.219 115.532 126.759 1.00 83.37  ? 134 GLU B O   1 
ATOM   3252 C CB  . GLU B 1 103 ? 159.470 117.892 126.759 1.00 95.57  ? 134 GLU B CB  1 
ATOM   3253 C CG  . GLU B 1 103 ? 160.923 118.341 126.736 1.00 100.35 ? 134 GLU B CG  1 
ATOM   3254 C CD  . GLU B 1 103 ? 161.261 119.280 127.879 1.00 107.25 ? 134 GLU B CD  1 
ATOM   3255 O OE1 . GLU B 1 103 ? 160.607 119.189 128.939 1.00 108.80 ? 134 GLU B OE1 1 
ATOM   3256 O OE2 . GLU B 1 103 ? 162.187 120.102 127.723 1.00 110.24 ? 134 GLU B OE2 1 
ATOM   3257 N N   . PHE B 1 104 ? 156.948 116.901 124.997 1.00 80.42  ? 135 PHE B N   1 
ATOM   3258 C CA  . PHE B 1 104 ? 155.499 116.732 125.043 1.00 76.53  ? 135 PHE B CA  1 
ATOM   3259 C C   . PHE B 1 104 ? 154.899 116.105 123.787 1.00 73.81  ? 135 PHE B C   1 
ATOM   3260 O O   . PHE B 1 104 ? 153.792 115.563 123.860 1.00 73.95  ? 135 PHE B O   1 
ATOM   3261 C CB  . PHE B 1 104 ? 154.788 118.067 125.363 1.00 74.88  ? 135 PHE B CB  1 
ATOM   3262 C CG  . PHE B 1 104 ? 155.042 119.201 124.386 1.00 80.70  ? 135 PHE B CG  1 
ATOM   3263 C CD1 . PHE B 1 104 ? 154.136 119.446 123.349 1.00 79.24  ? 135 PHE B CD1 1 
ATOM   3264 C CD2 . PHE B 1 104 ? 156.129 120.068 124.544 1.00 88.62  ? 135 PHE B CD2 1 
ATOM   3265 C CE1 . PHE B 1 104 ? 154.335 120.499 122.453 1.00 83.21  ? 135 PHE B CE1 1 
ATOM   3266 C CE2 . PHE B 1 104 ? 156.337 121.125 123.649 1.00 90.11  ? 135 PHE B CE2 1 
ATOM   3267 C CZ  . PHE B 1 104 ? 155.438 121.334 122.606 1.00 87.36  ? 135 PHE B CZ  1 
ATOM   3268 N N   . VAL B 1 105 ? 155.575 116.152 122.642 1.00 70.99  ? 136 VAL B N   1 
ATOM   3269 C CA  . VAL B 1 105 ? 155.080 115.513 121.427 1.00 62.86  ? 136 VAL B CA  1 
ATOM   3270 C C   . VAL B 1 105 ? 155.703 114.130 121.328 1.00 63.11  ? 136 VAL B C   1 
ATOM   3271 O O   . VAL B 1 105 ? 156.932 113.995 121.294 1.00 66.12  ? 136 VAL B O   1 
ATOM   3272 C CB  . VAL B 1 105 ? 155.385 116.350 120.174 1.00 66.31  ? 136 VAL B CB  1 
ATOM   3273 C CG1 . VAL B 1 105 ? 155.030 115.591 118.916 1.00 59.85  ? 136 VAL B CG1 1 
ATOM   3274 C CG2 . VAL B 1 105 ? 154.594 117.623 120.188 1.00 70.83  ? 136 VAL B CG2 1 
ATOM   3275 N N   . LYS B 1 106 ? 154.858 113.100 121.287 1.00 62.56  ? 137 LYS B N   1 
ATOM   3276 C CA  . LYS B 1 106 ? 155.301 111.728 121.064 1.00 59.12  ? 137 LYS B CA  1 
ATOM   3277 C C   . LYS B 1 106 ? 155.095 111.383 119.591 1.00 55.07  ? 137 LYS B C   1 
ATOM   3278 O O   . LYS B 1 106 ? 153.983 111.055 119.169 1.00 48.13  ? 137 LYS B O   1 
ATOM   3279 C CB  . LYS B 1 106 ? 154.539 110.773 121.976 1.00 53.94  ? 137 LYS B CB  1 
ATOM   3280 C CG  . LYS B 1 106 ? 154.449 111.262 123.406 1.00 56.07  ? 137 LYS B CG  1 
ATOM   3281 C CD  . LYS B 1 106 ? 153.543 110.390 124.250 1.00 61.43  ? 137 LYS B CD  1 
ATOM   3282 C CE  . LYS B 1 106 ? 154.115 110.212 125.646 1.00 67.40  ? 137 LYS B CE  1 
ATOM   3283 N NZ  . LYS B 1 106 ? 153.174 109.510 126.555 1.00 60.72  ? 137 LYS B NZ  1 
ATOM   3284 N N   . ILE B 1 107 ? 156.170 111.450 118.814 1.00 54.69  ? 138 ILE B N   1 
ATOM   3285 C CA  . ILE B 1 107 ? 156.128 111.219 117.378 1.00 49.54  ? 138 ILE B CA  1 
ATOM   3286 C C   . ILE B 1 107 ? 156.130 109.724 117.127 1.00 53.44  ? 138 ILE B C   1 
ATOM   3287 O O   . ILE B 1 107 ? 157.078 109.026 117.504 1.00 59.65  ? 138 ILE B O   1 
ATOM   3288 C CB  . ILE B 1 107 ? 157.325 111.877 116.671 1.00 53.65  ? 138 ILE B CB  1 
ATOM   3289 C CG1 . ILE B 1 107 ? 157.340 113.385 116.922 1.00 61.15  ? 138 ILE B CG1 1 
ATOM   3290 C CG2 . ILE B 1 107 ? 157.305 111.559 115.183 1.00 52.18  ? 138 ILE B CG2 1 
ATOM   3291 C CD1 . ILE B 1 107 ? 158.488 114.130 116.257 1.00 64.53  ? 138 ILE B CD1 1 
ATOM   3292 N N   . LEU B 1 108 ? 155.077 109.232 116.489 1.00 53.87  ? 139 LEU B N   1 
ATOM   3293 C CA  . LEU B 1 108 ? 155.052 107.887 115.939 1.00 51.62  ? 139 LEU B CA  1 
ATOM   3294 C C   . LEU B 1 108 ? 155.110 107.998 114.424 1.00 54.03  ? 139 LEU B C   1 
ATOM   3295 O O   . LEU B 1 108 ? 154.318 108.725 113.819 1.00 55.08  ? 139 LEU B O   1 
ATOM   3296 C CB  . LEU B 1 108 ? 153.800 107.132 116.382 1.00 45.20  ? 139 LEU B CB  1 
ATOM   3297 C CG  . LEU B 1 108 ? 153.715 105.654 116.024 1.00 51.23  ? 139 LEU B CG  1 
ATOM   3298 C CD1 . LEU B 1 108 ? 154.924 104.919 116.565 1.00 57.34  ? 139 LEU B CD1 1 
ATOM   3299 C CD2 . LEU B 1 108 ? 152.435 105.067 116.584 1.00 46.91  ? 139 LEU B CD2 1 
ATOM   3300 N N   . GLU B 1 109 ? 156.061 107.294 113.817 1.00 53.12  ? 140 GLU B N   1 
ATOM   3301 C CA  . GLU B 1 109 ? 156.470 107.554 112.442 1.00 57.39  ? 140 GLU B CA  1 
ATOM   3302 C C   . GLU B 1 109 ? 155.489 106.929 111.460 1.00 57.15  ? 140 GLU B C   1 
ATOM   3303 O O   . GLU B 1 109 ? 155.137 105.753 111.586 1.00 59.59  ? 140 GLU B O   1 
ATOM   3304 C CB  . GLU B 1 109 ? 157.884 107.026 112.193 1.00 63.43  ? 140 GLU B CB  1 
ATOM   3305 C CG  . GLU B 1 109 ? 158.490 107.456 110.867 1.00 67.31  ? 140 GLU B CG  1 
ATOM   3306 C CD  . GLU B 1 109 ? 159.953 107.072 110.742 1.00 75.85  ? 140 GLU B CD  1 
ATOM   3307 O OE1 . GLU B 1 109 ? 160.505 106.500 111.705 1.00 79.39  ? 140 GLU B OE1 1 
ATOM   3308 O OE2 . GLU B 1 109 ? 160.553 107.342 109.679 1.00 78.30  ? 140 GLU B OE2 1 
ATOM   3309 N N   . GLY B 1 110 ? 155.051 107.725 110.489 1.00 52.96  ? 141 GLY B N   1 
ATOM   3310 C CA  . GLY B 1 110 ? 154.140 107.249 109.468 1.00 45.31  ? 141 GLY B CA  1 
ATOM   3311 C C   . GLY B 1 110 ? 154.148 108.159 108.263 1.00 45.11  ? 141 GLY B C   1 
ATOM   3312 O O   . GLY B 1 110 ? 154.581 109.313 108.335 1.00 47.00  ? 141 GLY B O   1 
ATOM   3313 N N   . ASP B 1 111 ? 153.654 107.624 107.143 1.00 45.47  ? 142 ASP B N   1 
ATOM   3314 C CA  . ASP B 1 111 ? 153.752 108.342 105.878 1.00 42.64  ? 142 ASP B CA  1 
ATOM   3315 C C   . ASP B 1 111 ? 152.677 109.414 105.740 1.00 41.57  ? 142 ASP B C   1 
ATOM   3316 O O   . ASP B 1 111 ? 152.946 110.497 105.210 1.00 47.72  ? 142 ASP B O   1 
ATOM   3317 C CB  . ASP B 1 111 ? 153.700 107.362 104.711 1.00 42.44  ? 142 ASP B CB  1 
ATOM   3318 C CG  . ASP B 1 111 ? 154.901 106.445 104.682 1.00 48.11  ? 142 ASP B CG  1 
ATOM   3319 O OD1 . ASP B 1 111 ? 154.782 105.303 104.196 1.00 50.68  ? 142 ASP B OD1 1 
ATOM   3320 O OD2 . ASP B 1 111 ? 155.975 106.873 105.150 1.00 46.94  ? 142 ASP B OD2 1 
ATOM   3321 N N   . VAL B 1 112 ? 151.459 109.141 106.189 1.00 36.12  ? 143 VAL B N   1 
ATOM   3322 C CA  . VAL B 1 112 ? 150.388 110.130 106.170 1.00 38.05  ? 143 VAL B CA  1 
ATOM   3323 C C   . VAL B 1 112 ? 150.054 110.483 107.610 1.00 36.10  ? 143 VAL B C   1 
ATOM   3324 O O   . VAL B 1 112 ? 149.415 109.700 108.319 1.00 41.27  ? 143 VAL B O   1 
ATOM   3325 C CB  . VAL B 1 112 ? 149.157 109.620 105.407 1.00 45.91  ? 143 VAL B CB  1 
ATOM   3326 C CG1 . VAL B 1 112 ? 148.080 110.677 105.371 1.00 46.69  ? 143 VAL B CG1 1 
ATOM   3327 C CG2 . VAL B 1 112 ? 149.538 109.273 103.982 1.00 50.27  ? 143 VAL B CG2 1 
ATOM   3328 N N   . VAL B 1 113 ? 150.475 111.662 108.036 1.00 36.92  ? 144 VAL B N   1 
ATOM   3329 C CA  . VAL B 1 113 ? 150.516 112.021 109.441 1.00 40.41  ? 144 VAL B CA  1 
ATOM   3330 C C   . VAL B 1 113 ? 149.144 112.457 109.926 1.00 38.32  ? 144 VAL B C   1 
ATOM   3331 O O   . VAL B 1 113 ? 148.192 112.605 109.161 1.00 42.88  ? 144 VAL B O   1 
ATOM   3332 C CB  . VAL B 1 113 ? 151.560 113.122 109.722 1.00 44.49  ? 144 VAL B CB  1 
ATOM   3333 C CG1 . VAL B 1 113 ? 152.973 112.552 109.668 1.00 43.75  ? 144 VAL B CG1 1 
ATOM   3334 C CG2 . VAL B 1 113 ? 151.399 114.252 108.729 1.00 45.81  ? 144 VAL B CG2 1 
ATOM   3335 N N   . LEU B 1 114 ? 149.049 112.631 111.237 1.00 36.66  ? 145 LEU B N   1 
ATOM   3336 C CA  . LEU B 1 114 ? 147.866 113.087 111.944 1.00 36.03  ? 145 LEU B CA  1 
ATOM   3337 C C   . LEU B 1 114 ? 148.365 113.735 113.229 1.00 42.56  ? 145 LEU B C   1 
ATOM   3338 O O   . LEU B 1 114 ? 149.493 113.483 113.655 1.00 49.93  ? 145 LEU B O   1 
ATOM   3339 C CB  . LEU B 1 114 ? 146.909 111.906 112.203 1.00 36.79  ? 145 LEU B CB  1 
ATOM   3340 C CG  . LEU B 1 114 ? 145.544 111.990 112.891 1.00 41.24  ? 145 LEU B CG  1 
ATOM   3341 C CD1 . LEU B 1 114 ? 144.489 112.553 111.969 1.00 44.36  ? 145 LEU B CD1 1 
ATOM   3342 C CD2 . LEU B 1 114 ? 145.142 110.617 113.390 1.00 42.10  ? 145 LEU B CD2 1 
ATOM   3343 N N   . SER B 1 115 ? 147.561 114.603 113.825 1.00 40.18  ? 146 SER B N   1 
ATOM   3344 C CA  . SER B 1 115 ? 147.937 115.235 115.079 1.00 41.22  ? 146 SER B CA  1 
ATOM   3345 C C   . SER B 1 115 ? 146.764 115.171 116.037 1.00 42.72  ? 146 SER B C   1 
ATOM   3346 O O   . SER B 1 115 ? 145.613 115.259 115.613 1.00 48.60  ? 146 SER B O   1 
ATOM   3347 C CB  . SER B 1 115 ? 148.363 116.676 114.856 1.00 49.18  ? 146 SER B CB  1 
ATOM   3348 O OG  . SER B 1 115 ? 149.516 116.728 114.036 1.00 54.00  ? 146 SER B OG  1 
ATOM   3349 N N   . VAL B 1 116 ? 147.042 114.943 117.320 1.00 40.68  ? 147 VAL B N   1 
ATOM   3350 C CA  . VAL B 1 116 ? 146.009 114.867 118.349 1.00 43.84  ? 147 VAL B CA  1 
ATOM   3351 C C   . VAL B 1 116 ? 146.415 115.778 119.503 1.00 54.24  ? 147 VAL B C   1 
ATOM   3352 O O   . VAL B 1 116 ? 147.470 115.582 120.110 1.00 57.66  ? 147 VAL B O   1 
ATOM   3353 C CB  . VAL B 1 116 ? 145.782 113.421 118.846 1.00 44.77  ? 147 VAL B CB  1 
ATOM   3354 C CG1 . VAL B 1 116 ? 144.889 113.399 120.048 1.00 48.64  ? 147 VAL B CG1 1 
ATOM   3355 C CG2 . VAL B 1 116 ? 145.126 112.561 117.791 1.00 45.77  ? 147 VAL B CG2 1 
ATOM   3356 N N   . LEU B 1 117 ? 145.585 116.773 119.807 1.00 58.92  ? 148 LEU B N   1 
ATOM   3357 C CA  . LEU B 1 117 ? 145.837 117.710 120.905 1.00 59.79  ? 148 LEU B CA  1 
ATOM   3358 C C   . LEU B 1 117 ? 145.034 117.230 122.113 1.00 62.75  ? 148 LEU B C   1 
ATOM   3359 O O   . LEU B 1 117 ? 143.861 117.570 122.268 1.00 65.90  ? 148 LEU B O   1 
ATOM   3360 C CB  . LEU B 1 117 ? 145.453 119.126 120.501 1.00 64.71  ? 148 LEU B CB  1 
ATOM   3361 C CG  . LEU B 1 117 ? 145.777 120.273 121.459 1.00 75.06  ? 148 LEU B CG  1 
ATOM   3362 C CD1 . LEU B 1 117 ? 147.171 120.799 121.192 1.00 78.37  ? 148 LEU B CD1 1 
ATOM   3363 C CD2 . LEU B 1 117 ? 144.751 121.391 121.339 1.00 80.73  ? 148 LEU B CD2 1 
ATOM   3364 N N   . THR B 1 118 ? 145.674 116.448 122.980 1.00 63.14  ? 149 THR B N   1 
ATOM   3365 C CA  . THR B 1 118 ? 144.973 115.740 124.042 1.00 63.62  ? 149 THR B CA  1 
ATOM   3366 C C   . THR B 1 118 ? 145.649 115.943 125.388 1.00 68.88  ? 149 THR B C   1 
ATOM   3367 O O   . THR B 1 118 ? 146.788 116.409 125.472 1.00 72.08  ? 149 THR B O   1 
ATOM   3368 C CB  . THR B 1 118 ? 144.904 114.244 123.766 1.00 64.03  ? 149 THR B CB  1 
ATOM   3369 O OG1 . THR B 1 118 ? 144.308 113.582 124.887 1.00 64.99  ? 149 THR B OG1 1 
ATOM   3370 C CG2 . THR B 1 118 ? 146.296 113.693 123.546 1.00 60.88  ? 149 THR B CG2 1 
ATOM   3371 N N   . LYS B 1 119 ? 144.923 115.586 126.448 1.00 68.40  ? 150 LYS B N   1 
ATOM   3372 C CA  . LYS B 1 119 ? 145.523 115.565 127.777 1.00 68.89  ? 150 LYS B CA  1 
ATOM   3373 C C   . LYS B 1 119 ? 146.166 114.216 128.062 1.00 62.62  ? 150 LYS B C   1 
ATOM   3374 O O   . LYS B 1 119 ? 147.104 114.122 128.862 1.00 62.75  ? 150 LYS B O   1 
ATOM   3375 C CB  . LYS B 1 119 ? 144.474 115.898 128.836 1.00 67.93  ? 150 LYS B CB  1 
ATOM   3376 C CG  . LYS B 1 119 ? 144.004 117.339 128.791 1.00 76.66  ? 150 LYS B CG  1 
ATOM   3377 C CD  . LYS B 1 119 ? 142.866 117.594 129.762 1.00 77.17  ? 150 LYS B CD  1 
ATOM   3378 C CE  . LYS B 1 119 ? 143.343 117.554 131.201 1.00 74.28  ? 150 LYS B CE  1 
ATOM   3379 N NZ  . LYS B 1 119 ? 142.250 117.917 132.143 1.00 75.60  ? 150 LYS B NZ  1 
ATOM   3380 N N   . ASP B 1 120 ? 145.674 113.158 127.415 1.00 60.49  ? 151 ASP B N   1 
ATOM   3381 C CA  . ASP B 1 120 ? 146.180 111.808 127.605 1.00 57.85  ? 151 ASP B CA  1 
ATOM   3382 C C   . ASP B 1 120 ? 146.800 111.327 126.299 1.00 55.70  ? 151 ASP B C   1 
ATOM   3383 O O   . ASP B 1 120 ? 146.074 110.849 125.417 1.00 55.46  ? 151 ASP B O   1 
ATOM   3384 C CB  . ASP B 1 120 ? 145.051 110.873 128.046 1.00 55.24  ? 151 ASP B CB  1 
ATOM   3385 C CG  . ASP B 1 120 ? 145.548 109.508 128.473 1.00 54.69  ? 151 ASP B CG  1 
ATOM   3386 O OD1 . ASP B 1 120 ? 146.728 109.383 128.859 1.00 55.42  ? 151 ASP B OD1 1 
ATOM   3387 O OD2 . ASP B 1 120 ? 144.750 108.554 128.444 1.00 55.17  ? 151 ASP B OD2 1 
ATOM   3388 N N   . PRO B 1 121 ? 148.121 111.429 126.120 1.00 54.52  ? 152 PRO B N   1 
ATOM   3389 C CA  . PRO B 1 121 ? 148.700 111.048 124.825 1.00 51.09  ? 152 PRO B CA  1 
ATOM   3390 C C   . PRO B 1 121 ? 149.073 109.585 124.732 1.00 49.76  ? 152 PRO B C   1 
ATOM   3391 O O   . PRO B 1 121 ? 149.428 109.121 123.645 1.00 52.99  ? 152 PRO B O   1 
ATOM   3392 C CB  . PRO B 1 121 ? 149.932 111.952 124.731 1.00 57.72  ? 152 PRO B CB  1 
ATOM   3393 C CG  . PRO B 1 121 ? 150.368 112.072 126.138 1.00 62.19  ? 152 PRO B CG  1 
ATOM   3394 C CD  . PRO B 1 121 ? 149.107 112.123 126.967 1.00 60.46  ? 152 PRO B CD  1 
ATOM   3395 N N   . ASP B 1 122 ? 149.033 108.849 125.842 1.00 47.90  ? 153 ASP B N   1 
ATOM   3396 C CA  . ASP B 1 122 ? 149.365 107.429 125.798 1.00 46.46  ? 153 ASP B CA  1 
ATOM   3397 C C   . ASP B 1 122 ? 148.229 106.620 125.192 1.00 44.50  ? 153 ASP B C   1 
ATOM   3398 O O   . ASP B 1 122 ? 148.462 105.597 124.542 1.00 43.80  ? 153 ASP B O   1 
ATOM   3399 C CB  . ASP B 1 122 ? 149.685 106.927 127.203 1.00 53.89  ? 153 ASP B CB  1 
ATOM   3400 C CG  . ASP B 1 122 ? 151.137 107.112 127.568 1.00 62.33  ? 153 ASP B CG  1 
ATOM   3401 O OD1 . ASP B 1 122 ? 151.446 107.116 128.778 1.00 65.22  ? 153 ASP B OD1 1 
ATOM   3402 O OD2 . ASP B 1 122 ? 151.967 107.261 126.646 1.00 59.37  ? 153 ASP B OD2 1 
ATOM   3403 N N   . SER B 1 123 ? 146.991 107.070 125.396 1.00 46.64  ? 154 SER B N   1 
ATOM   3404 C CA  . SER B 1 123 ? 145.837 106.380 124.833 1.00 45.13  ? 154 SER B CA  1 
ATOM   3405 C C   . SER B 1 123 ? 145.663 106.697 123.356 1.00 42.10  ? 154 SER B C   1 
ATOM   3406 O O   . SER B 1 123 ? 145.058 105.917 122.616 1.00 42.98  ? 154 SER B O   1 
ATOM   3407 C CB  . SER B 1 123 ? 144.584 106.763 125.607 1.00 47.45  ? 154 SER B CB  1 
ATOM   3408 O OG  . SER B 1 123 ? 144.492 108.167 125.728 1.00 50.50  ? 154 SER B OG  1 
ATOM   3409 N N   . ALA B 1 124 ? 146.164 107.850 122.913 1.00 42.99  ? 155 ALA B N   1 
ATOM   3410 C CA  . ALA B 1 124 ? 146.061 108.210 121.504 1.00 40.97  ? 155 ALA B CA  1 
ATOM   3411 C C   . ALA B 1 124 ? 147.082 107.452 120.666 1.00 38.33  ? 155 ALA B C   1 
ATOM   3412 O O   . ALA B 1 124 ? 146.838 107.153 119.497 1.00 37.63  ? 155 ALA B O   1 
ATOM   3413 C CB  . ALA B 1 124 ? 146.231 109.719 121.332 1.00 41.88  ? 155 ALA B CB  1 
ATOM   3414 N N   . LEU B 1 125 ? 148.239 107.136 121.248 1.00 38.33  ? 156 LEU B N   1 
ATOM   3415 C CA  . LEU B 1 125 ? 149.251 106.379 120.518 1.00 35.97  ? 156 LEU B CA  1 
ATOM   3416 C C   . LEU B 1 125 ? 148.914 104.901 120.453 1.00 39.36  ? 156 LEU B C   1 
ATOM   3417 O O   . LEU B 1 125 ? 149.450 104.183 119.605 1.00 45.92  ? 156 LEU B O   1 
ATOM   3418 C CB  . LEU B 1 125 ? 150.628 106.558 121.153 1.00 40.99  ? 156 LEU B CB  1 
ATOM   3419 C CG  . LEU B 1 125 ? 151.620 107.551 120.553 1.00 40.51  ? 156 LEU B CG  1 
ATOM   3420 C CD1 . LEU B 1 125 ? 151.183 108.950 120.769 1.00 41.50  ? 156 LEU B CD1 1 
ATOM   3421 C CD2 . LEU B 1 125 ? 152.972 107.338 121.180 1.00 43.60  ? 156 LEU B CD2 1 
ATOM   3422 N N   . PHE B 1 126 ? 148.060 104.419 121.357 1.00 38.94  ? 157 PHE B N   1 
ATOM   3423 C CA  . PHE B 1 126 ? 147.698 103.007 121.347 1.00 39.78  ? 157 PHE B CA  1 
ATOM   3424 C C   . PHE B 1 126 ? 146.710 102.698 120.234 1.00 42.64  ? 157 PHE B C   1 
ATOM   3425 O O   . PHE B 1 126 ? 146.735 101.599 119.670 1.00 46.03  ? 157 PHE B O   1 
ATOM   3426 C CB  . PHE B 1 126 ? 147.116 102.596 122.694 1.00 40.60  ? 157 PHE B CB  1 
ATOM   3427 C CG  . PHE B 1 126 ? 146.784 101.144 122.781 1.00 40.97  ? 157 PHE B CG  1 
ATOM   3428 C CD1 . PHE B 1 126 ? 147.756 100.185 122.504 1.00 43.32  ? 157 PHE B CD1 1 
ATOM   3429 C CD2 . PHE B 1 126 ? 145.490 100.736 123.088 1.00 41.93  ? 157 PHE B CD2 1 
ATOM   3430 C CE1 . PHE B 1 126 ? 147.453 98.829  122.569 1.00 46.97  ? 157 PHE B CE1 1 
ATOM   3431 C CE2 . PHE B 1 126 ? 145.171 99.385  123.155 1.00 45.06  ? 157 PHE B CE2 1 
ATOM   3432 C CZ  . PHE B 1 126 ? 146.156 98.432  122.894 1.00 46.89  ? 157 PHE B CZ  1 
ATOM   3433 N N   . VAL B 1 127 ? 145.836 103.659 119.911 1.00 40.65  ? 158 VAL B N   1 
ATOM   3434 C CA  . VAL B 1 127 ? 144.835 103.480 118.861 1.00 34.57  ? 158 VAL B CA  1 
ATOM   3435 C C   . VAL B 1 127 ? 145.492 103.451 117.490 1.00 36.43  ? 158 VAL B C   1 
ATOM   3436 O O   . VAL B 1 127 ? 145.257 102.531 116.702 1.00 41.28  ? 158 VAL B O   1 
ATOM   3437 C CB  . VAL B 1 127 ? 143.771 104.585 118.961 1.00 30.09  ? 158 VAL B CB  1 
ATOM   3438 C CG1 . VAL B 1 127 ? 142.783 104.505 117.820 1.00 32.97  ? 158 VAL B CG1 1 
ATOM   3439 C CG2 . VAL B 1 127 ? 143.049 104.487 120.280 1.00 34.19  ? 158 VAL B CG2 1 
ATOM   3440 N N   . ILE B 1 128 ? 146.432 104.368 117.248 1.00 38.16  ? 159 ILE B N   1 
ATOM   3441 C CA  . ILE B 1 128 ? 147.112 104.469 115.956 1.00 37.62  ? 159 ILE B CA  1 
ATOM   3442 C C   . ILE B 1 128 ? 148.168 103.362 115.812 1.00 39.79  ? 159 ILE B C   1 
ATOM   3443 O O   . ILE B 1 128 ? 148.567 103.001 114.699 1.00 45.87  ? 159 ILE B O   1 
ATOM   3444 C CB  . ILE B 1 128 ? 147.683 105.900 115.807 1.00 33.85  ? 159 ILE B CB  1 
ATOM   3445 C CG1 . ILE B 1 128 ? 146.615 106.939 116.174 1.00 35.14  ? 159 ILE B CG1 1 
ATOM   3446 C CG2 . ILE B 1 128 ? 148.130 106.257 114.394 1.00 34.04  ? 159 ILE B CG2 1 
ATOM   3447 C CD1 . ILE B 1 128 ? 145.368 106.993 115.270 1.00 34.65  ? 159 ILE B CD1 1 
ATOM   3448 N N   . ASN B 1 129 ? 148.591 102.756 116.924 1.00 37.89  ? 160 ASN B N   1 
ATOM   3449 C CA  . ASN B 1 129 ? 149.322 101.495 116.838 1.00 40.16  ? 160 ASN B CA  1 
ATOM   3450 C C   . ASN B 1 129 ? 148.403 100.358 116.407 1.00 44.29  ? 160 ASN B C   1 
ATOM   3451 O O   . ASN B 1 129 ? 148.796 99.490  115.619 1.00 49.83  ? 160 ASN B O   1 
ATOM   3452 C CB  . ASN B 1 129 ? 149.981 101.172 118.177 1.00 46.93  ? 160 ASN B CB  1 
ATOM   3453 C CG  . ASN B 1 129 ? 150.581 99.782  118.214 1.00 52.57  ? 160 ASN B CG  1 
ATOM   3454 O OD1 . ASN B 1 129 ? 150.205 98.954  119.038 1.00 56.29  ? 160 ASN B OD1 1 
ATOM   3455 N ND2 . ASN B 1 129 ? 151.498 99.511  117.299 1.00 52.30  ? 160 ASN B ND2 1 
ATOM   3456 N N   . ARG B 1 130 ? 147.155 100.373 116.879 1.00 45.50  ? 161 ARG B N   1 
ATOM   3457 C CA  . ARG B 1 130 ? 146.251 99.261  116.597 1.00 46.36  ? 161 ARG B CA  1 
ATOM   3458 C C   . ARG B 1 130 ? 145.599 99.380  115.221 1.00 48.46  ? 161 ARG B C   1 
ATOM   3459 O O   . ARG B 1 130 ? 145.021 98.406  114.729 1.00 51.77  ? 161 ARG B O   1 
ATOM   3460 C CB  . ARG B 1 130 ? 145.188 99.160  117.685 1.00 37.23  ? 161 ARG B CB  1 
ATOM   3461 C CG  . ARG B 1 130 ? 145.677 98.518  118.952 1.00 40.59  ? 161 ARG B CG  1 
ATOM   3462 C CD  . ARG B 1 130 ? 145.997 97.066  118.745 1.00 44.34  ? 161 ARG B CD  1 
ATOM   3463 N NE  . ARG B 1 130 ? 147.420 96.793  118.851 1.00 45.50  ? 161 ARG B NE  1 
ATOM   3464 C CZ  . ARG B 1 130 ? 147.969 95.615  118.602 1.00 51.48  ? 161 ARG B CZ  1 
ATOM   3465 N NH1 . ARG B 1 130 ? 147.240 94.579  118.228 1.00 50.83  ? 161 ARG B NH1 1 
ATOM   3466 N NH2 . ARG B 1 130 ? 149.282 95.471  118.734 1.00 59.61  ? 161 ARG B NH2 1 
ATOM   3467 N N   . VAL B 1 131 ? 145.654 100.562 114.599 1.00 45.21  ? 162 VAL B N   1 
ATOM   3468 C CA  . VAL B 1 131 ? 145.175 100.704 113.225 1.00 41.64  ? 162 VAL B CA  1 
ATOM   3469 C C   . VAL B 1 131 ? 146.135 100.039 112.248 1.00 45.64  ? 162 VAL B C   1 
ATOM   3470 O O   . VAL B 1 131 ? 145.717 99.247  111.393 1.00 52.81  ? 162 VAL B O   1 
ATOM   3471 C CB  . VAL B 1 131 ? 144.943 102.191 112.888 1.00 41.29  ? 162 VAL B CB  1 
ATOM   3472 C CG1 . VAL B 1 131 ? 144.560 102.381 111.434 1.00 47.30  ? 162 VAL B CG1 1 
ATOM   3473 C CG2 . VAL B 1 131 ? 143.805 102.713 113.703 1.00 41.30  ? 162 VAL B CG2 1 
ATOM   3474 N N   . ASN B 1 132 ? 147.439 100.298 112.408 1.00 45.30  ? 163 ASN B N   1 
ATOM   3475 C CA  . ASN B 1 132 ? 148.436 99.909  111.412 1.00 49.90  ? 163 ASN B CA  1 
ATOM   3476 C C   . ASN B 1 132 ? 148.734 98.416  111.454 1.00 54.46  ? 163 ASN B C   1 
ATOM   3477 O O   . ASN B 1 132 ? 149.171 97.835  110.454 1.00 57.82  ? 163 ASN B O   1 
ATOM   3478 C CB  . ASN B 1 132 ? 149.716 100.700 111.634 1.00 44.56  ? 163 ASN B CB  1 
ATOM   3479 C CG  . ASN B 1 132 ? 149.459 102.165 111.768 1.00 43.50  ? 163 ASN B CG  1 
ATOM   3480 O OD1 . ASN B 1 132 ? 148.359 102.637 111.499 1.00 41.52  ? 163 ASN B OD1 1 
ATOM   3481 N ND2 . ASN B 1 132 ? 150.464 102.900 112.216 1.00 43.94  ? 163 ASN B ND2 1 
ATOM   3482 N N   . GLN B 1 133 ? 148.505 97.780  112.600 1.00 50.29  ? 164 GLN B N   1 
ATOM   3483 C CA  . GLN B 1 133 ? 148.657 96.335  112.662 1.00 52.03  ? 164 GLN B CA  1 
ATOM   3484 C C   . GLN B 1 133 ? 147.422 95.632  112.116 1.00 53.96  ? 164 GLN B C   1 
ATOM   3485 O O   . GLN B 1 133 ? 147.499 94.477  111.682 1.00 57.81  ? 164 GLN B O   1 
ATOM   3486 C CB  . GLN B 1 133 ? 148.948 95.907  114.094 1.00 52.68  ? 164 GLN B CB  1 
ATOM   3487 C CG  . GLN B 1 133 ? 150.261 96.439  114.598 1.00 53.57  ? 164 GLN B CG  1 
ATOM   3488 C CD  . GLN B 1 133 ? 151.433 95.734  113.964 1.00 60.91  ? 164 GLN B CD  1 
ATOM   3489 O OE1 . GLN B 1 133 ? 151.631 94.539  114.157 1.00 62.08  ? 164 GLN B OE1 1 
ATOM   3490 N NE2 . GLN B 1 133 ? 152.219 96.474  113.193 1.00 62.68  ? 164 GLN B NE2 1 
ATOM   3491 N N   . ALA B 1 134 ? 146.275 96.315  112.122 1.00 50.98  ? 165 ALA B N   1 
ATOM   3492 C CA  . ALA B 1 134 ? 145.044 95.698  111.646 1.00 51.63  ? 165 ALA B CA  1 
ATOM   3493 C C   . ALA B 1 134 ? 144.847 95.891  110.150 1.00 54.22  ? 165 ALA B C   1 
ATOM   3494 O O   . ALA B 1 134 ? 144.167 95.065  109.525 1.00 57.23  ? 165 ALA B O   1 
ATOM   3495 C CB  . ALA B 1 134 ? 143.841 96.259  112.400 1.00 48.84  ? 165 ALA B CB  1 
ATOM   3496 N N   . ASN B 1 135 ? 145.458 96.953  109.583 1.00 52.70  ? 166 ASN B N   1 
ATOM   3497 C CA  . ASN B 1 135 ? 145.232 97.480  108.222 1.00 49.66  ? 166 ASN B CA  1 
ATOM   3498 C C   . ASN B 1 135 ? 143.752 97.757  107.957 1.00 51.02  ? 166 ASN B C   1 
ATOM   3499 O O   . ASN B 1 135 ? 143.092 97.036  107.207 1.00 53.83  ? 166 ASN B O   1 
ATOM   3500 C CB  . ASN B 1 135 ? 145.828 96.585  107.124 1.00 52.27  ? 166 ASN B CB  1 
ATOM   3501 C CG  . ASN B 1 135 ? 147.279 96.888  106.847 1.00 59.64  ? 166 ASN B CG  1 
ATOM   3502 O OD1 . ASN B 1 135 ? 147.696 98.045  106.854 1.00 57.60  ? 166 ASN B OD1 1 
ATOM   3503 N ND2 . ASN B 1 135 ? 148.059 95.848  106.584 1.00 65.11  ? 166 ASN B ND2 1 
ATOM   3504 N N   . LEU B 1 136 ? 143.218 98.773  108.648 1.00 48.95  ? 167 LEU B N   1 
ATOM   3505 C CA  . LEU B 1 136 ? 141.865 99.251  108.375 1.00 52.29  ? 167 LEU B CA  1 
ATOM   3506 C C   . LEU B 1 136 ? 141.733 99.866  106.990 1.00 58.72  ? 167 LEU B C   1 
ATOM   3507 O O   . LEU B 1 136 ? 140.675 99.739  106.366 1.00 61.23  ? 167 LEU B O   1 
ATOM   3508 C CB  . LEU B 1 136 ? 141.432 100.294 109.404 1.00 50.26  ? 167 LEU B CB  1 
ATOM   3509 C CG  . LEU B 1 136 ? 141.228 99.914  110.864 1.00 52.00  ? 167 LEU B CG  1 
ATOM   3510 C CD1 . LEU B 1 136 ? 140.910 101.169 111.647 1.00 49.88  ? 167 LEU B CD1 1 
ATOM   3511 C CD2 . LEU B 1 136 ? 140.122 98.889  111.021 1.00 52.89  ? 167 LEU B CD2 1 
ATOM   3512 N N   . ILE B 1 137 ? 142.782 100.523 106.494 1.00 57.27  ? 168 ILE B N   1 
ATOM   3513 C CA  . ILE B 1 137 ? 142.757 101.138 105.179 1.00 53.70  ? 168 ILE B CA  1 
ATOM   3514 C C   . ILE B 1 137 ? 143.281 100.217 104.094 1.00 54.70  ? 168 ILE B C   1 
ATOM   3515 O O   . ILE B 1 137 ? 143.194 100.582 102.912 1.00 60.18  ? 168 ILE B O   1 
ATOM   3516 C CB  . ILE B 1 137 ? 143.549 102.453 105.190 1.00 57.98  ? 168 ILE B CB  1 
ATOM   3517 C CG1 . ILE B 1 137 ? 144.971 102.201 105.691 1.00 61.82  ? 168 ILE B CG1 1 
ATOM   3518 C CG2 . ILE B 1 137 ? 142.838 103.461 106.052 1.00 54.88  ? 168 ILE B CG2 1 
ATOM   3519 C CD1 . ILE B 1 137 ? 145.872 103.416 105.625 1.00 57.66  ? 168 ILE B CD1 1 
ATOM   3520 N N   . MET B 1 138 ? 143.725 99.003  104.466 1.00 57.39  ? 169 MET B N   1 
ATOM   3521 C CA  . MET B 1 138 ? 144.418 97.946  103.686 1.00 61.19  ? 169 MET B CA  1 
ATOM   3522 C C   . MET B 1 138 ? 145.472 98.484  102.708 1.00 62.00  ? 169 MET B C   1 
ATOM   3523 O O   . MET B 1 138 ? 145.545 98.107  101.537 1.00 62.74  ? 169 MET B O   1 
ATOM   3524 C CB  . MET B 1 138 ? 143.430 96.972  103.002 1.00 63.99  ? 169 MET B CB  1 
ATOM   3525 C CG  . MET B 1 138 ? 142.314 97.478  102.071 1.00 66.80  ? 169 MET B CG  1 
ATOM   3526 S SD  . MET B 1 138 ? 141.288 96.153  101.411 1.00 80.82  ? 169 MET B SD  1 
ATOM   3527 C CE  . MET B 1 138 ? 142.416 95.424  100.228 1.00 76.42  ? 169 MET B CE  1 
ATOM   3528 N N   . ALA B 1 139 ? 146.336 99.342  103.242 1.00 60.92  ? 170 ALA B N   1 
ATOM   3529 C CA  . ALA B 1 139 ? 147.349 100.017 102.450 1.00 65.06  ? 170 ALA B CA  1 
ATOM   3530 C C   . ALA B 1 139 ? 148.712 99.779  103.082 1.00 68.56  ? 170 ALA B C   1 
ATOM   3531 O O   . ALA B 1 139 ? 148.816 99.461  104.267 1.00 67.85  ? 170 ALA B O   1 
ATOM   3532 C CB  . ALA B 1 139 ? 147.046 101.508 102.337 1.00 63.82  ? 170 ALA B CB  1 
ATOM   3533 N N   . ASP B 1 140 ? 149.767 99.919  102.269 1.00 68.85  ? 171 ASP B N   1 
ATOM   3534 C CA  . ASP B 1 140 ? 151.106 99.556  102.732 1.00 66.18  ? 171 ASP B CA  1 
ATOM   3535 C C   . ASP B 1 140 ? 151.718 100.625 103.627 1.00 64.05  ? 171 ASP B C   1 
ATOM   3536 O O   . ASP B 1 140 ? 152.643 100.334 104.393 1.00 69.32  ? 171 ASP B O   1 
ATOM   3537 C CB  . ASP B 1 140 ? 152.030 99.252  101.547 1.00 65.71  ? 171 ASP B CB  1 
ATOM   3538 C CG  . ASP B 1 140 ? 152.104 100.376 100.529 1.00 68.52  ? 171 ASP B CG  1 
ATOM   3539 O OD1 . ASP B 1 140 ? 151.344 101.364 100.605 1.00 67.20  ? 171 ASP B OD1 1 
ATOM   3540 O OD2 . ASP B 1 140 ? 152.956 100.271 99.620  1.00 69.15  ? 171 ASP B OD2 1 
ATOM   3541 N N   . PHE B 1 141 ? 151.236 101.860 103.531 1.00 58.45  ? 172 PHE B N   1 
ATOM   3542 C CA  . PHE B 1 141 ? 151.751 102.895 104.408 1.00 58.09  ? 172 PHE B CA  1 
ATOM   3543 C C   . PHE B 1 141 ? 151.080 102.810 105.774 1.00 54.08  ? 172 PHE B C   1 
ATOM   3544 O O   . PHE B 1 141 ? 150.111 102.079 105.982 1.00 58.65  ? 172 PHE B O   1 
ATOM   3545 C CB  . PHE B 1 141 ? 151.596 104.298 103.791 1.00 57.04  ? 172 PHE B CB  1 
ATOM   3546 C CG  . PHE B 1 141 ? 150.182 104.714 103.447 1.00 57.92  ? 172 PHE B CG  1 
ATOM   3547 C CD1 . PHE B 1 141 ? 149.661 104.450 102.179 1.00 59.87  ? 172 PHE B CD1 1 
ATOM   3548 C CD2 . PHE B 1 141 ? 149.417 105.468 104.350 1.00 55.79  ? 172 PHE B CD2 1 
ATOM   3549 C CE1 . PHE B 1 141 ? 148.381 104.868 101.837 1.00 61.17  ? 172 PHE B CE1 1 
ATOM   3550 C CE2 . PHE B 1 141 ? 148.133 105.876 104.026 1.00 56.56  ? 172 PHE B CE2 1 
ATOM   3551 C CZ  . PHE B 1 141 ? 147.619 105.580 102.767 1.00 60.33  ? 172 PHE B CZ  1 
ATOM   3552 N N   . GLU B 1 142 ? 151.608 103.583 106.708 1.00 46.20  ? 173 GLU B N   1 
ATOM   3553 C CA  . GLU B 1 142 ? 151.117 103.587 108.071 1.00 43.53  ? 173 GLU B CA  1 
ATOM   3554 C C   . GLU B 1 142 ? 150.746 105.007 108.450 1.00 38.22  ? 173 GLU B C   1 
ATOM   3555 O O   . GLU B 1 142 ? 151.399 105.962 108.037 1.00 45.08  ? 173 GLU B O   1 
ATOM   3556 C CB  . GLU B 1 142 ? 152.169 103.026 109.025 1.00 51.37  ? 173 GLU B CB  1 
ATOM   3557 C CG  . GLU B 1 142 ? 152.277 101.505 108.975 1.00 57.77  ? 173 GLU B CG  1 
ATOM   3558 C CD  . GLU B 1 142 ? 153.220 100.946 110.020 1.00 66.30  ? 173 GLU B CD  1 
ATOM   3559 O OE1 . GLU B 1 142 ? 153.844 101.746 110.749 1.00 66.29  ? 173 GLU B OE1 1 
ATOM   3560 O OE2 . GLU B 1 142 ? 153.333 99.705  110.112 1.00 64.26  ? 173 GLU B OE2 1 
ATOM   3561 N N   . ILE B 1 143 ? 149.678 105.142 109.201 1.00 32.55  ? 174 ILE B N   1 
ATOM   3562 C CA  . ILE B 1 143 ? 149.270 106.450 109.684 1.00 32.89  ? 174 ILE B CA  1 
ATOM   3563 C C   . ILE B 1 143 ? 150.145 106.820 110.868 1.00 39.57  ? 174 ILE B C   1 
ATOM   3564 O O   . ILE B 1 143 ? 150.291 106.044 111.816 1.00 45.53  ? 174 ILE B O   1 
ATOM   3565 C CB  . ILE B 1 143 ? 147.780 106.441 110.059 1.00 36.24  ? 174 ILE B CB  1 
ATOM   3566 C CG1 . ILE B 1 143 ? 146.942 105.991 108.862 1.00 46.86  ? 174 ILE B CG1 1 
ATOM   3567 C CG2 . ILE B 1 143 ? 147.327 107.808 110.538 1.00 37.60  ? 174 ILE B CG2 1 
ATOM   3568 C CD1 . ILE B 1 143 ? 147.028 106.910 107.652 1.00 47.35  ? 174 ILE B CD1 1 
ATOM   3569 N N   . GLY B 1 144 ? 150.765 107.985 110.802 1.00 39.88  ? 175 GLY B N   1 
ATOM   3570 C CA  . GLY B 1 144 ? 151.545 108.512 111.911 1.00 38.28  ? 175 GLY B CA  1 
ATOM   3571 C C   . GLY B 1 144 ? 150.657 109.355 112.790 1.00 38.27  ? 175 GLY B C   1 
ATOM   3572 O O   . GLY B 1 144 ? 149.584 109.786 112.368 1.00 41.01  ? 175 GLY B O   1 
ATOM   3573 N N   . ILE B 1 145 ? 151.082 109.562 114.030 1.00 36.22  ? 176 ILE B N   1 
ATOM   3574 C CA  . ILE B 1 145 ? 150.420 110.484 114.938 1.00 35.57  ? 176 ILE B CA  1 
ATOM   3575 C C   . ILE B 1 145 ? 151.491 111.374 115.562 1.00 42.82  ? 176 ILE B C   1 
ATOM   3576 O O   . ILE B 1 145 ? 152.566 110.894 115.940 1.00 49.19  ? 176 ILE B O   1 
ATOM   3577 C CB  . ILE B 1 145 ? 149.556 109.735 115.982 1.00 33.37  ? 176 ILE B CB  1 
ATOM   3578 C CG1 . ILE B 1 145 ? 148.916 110.684 117.001 1.00 36.45  ? 176 ILE B CG1 1 
ATOM   3579 C CG2 . ILE B 1 145 ? 150.293 108.563 116.639 1.00 39.64  ? 176 ILE B CG2 1 
ATOM   3580 C CD1 . ILE B 1 145 ? 147.952 110.030 117.923 1.00 39.34  ? 176 ILE B CD1 1 
ATOM   3581 N N   . ARG B 1 146 ? 151.245 112.681 115.564 1.00 43.51  ? 177 ARG B N   1 
ATOM   3582 C CA  . ARG B 1 146 ? 152.066 113.622 116.314 1.00 45.03  ? 177 ARG B CA  1 
ATOM   3583 C C   . ARG B 1 146 ? 151.207 114.154 117.449 1.00 47.95  ? 177 ARG B C   1 
ATOM   3584 O O   . ARG B 1 146 ? 150.602 115.220 117.335 1.00 51.42  ? 177 ARG B O   1 
ATOM   3585 C CB  . ARG B 1 146 ? 152.562 114.737 115.408 1.00 47.77  ? 177 ARG B CB  1 
ATOM   3586 C CG  . ARG B 1 146 ? 153.471 114.248 114.305 1.00 54.43  ? 177 ARG B CG  1 
ATOM   3587 C CD  . ARG B 1 146 ? 153.928 115.380 113.417 1.00 59.32  ? 177 ARG B CD  1 
ATOM   3588 N NE  . ARG B 1 146 ? 154.119 116.608 114.174 1.00 64.15  ? 177 ARG B NE  1 
ATOM   3589 C CZ  . ARG B 1 146 ? 155.284 117.008 114.657 1.00 66.94  ? 177 ARG B CZ  1 
ATOM   3590 N NH1 . ARG B 1 146 ? 156.385 116.297 114.476 1.00 62.98  ? 177 ARG B NH1 1 
ATOM   3591 N NH2 . ARG B 1 146 ? 155.346 118.147 115.340 1.00 71.26  ? 177 ARG B NH2 1 
ATOM   3592 N N   . ALA B 1 147 ? 151.160 113.418 118.554 1.00 46.89  ? 178 ALA B N   1 
ATOM   3593 C CA  . ALA B 1 147 ? 150.207 113.700 119.617 1.00 46.28  ? 178 ALA B CA  1 
ATOM   3594 C C   . ALA B 1 147 ? 150.788 114.708 120.593 1.00 52.18  ? 178 ALA B C   1 
ATOM   3595 O O   . ALA B 1 147 ? 151.872 114.497 121.138 1.00 56.45  ? 178 ALA B O   1 
ATOM   3596 C CB  . ALA B 1 147 ? 149.806 112.428 120.352 1.00 45.23  ? 178 ALA B CB  1 
ATOM   3597 N N   . ILE B 1 148 ? 150.042 115.776 120.840 1.00 55.94  ? 179 ILE B N   1 
ATOM   3598 C CA  . ILE B 1 148 ? 150.486 116.894 121.660 1.00 61.81  ? 179 ILE B CA  1 
ATOM   3599 C C   . ILE B 1 148 ? 149.897 116.726 123.052 1.00 65.16  ? 179 ILE B C   1 
ATOM   3600 O O   . ILE B 1 148 ? 148.699 116.462 123.195 1.00 67.46  ? 179 ILE B O   1 
ATOM   3601 C CB  . ILE B 1 148 ? 150.060 118.235 121.042 1.00 64.10  ? 179 ILE B CB  1 
ATOM   3602 C CG1 . ILE B 1 148 ? 150.242 118.197 119.521 1.00 61.74  ? 179 ILE B CG1 1 
ATOM   3603 C CG2 . ILE B 1 148 ? 150.856 119.367 121.653 1.00 71.12  ? 179 ILE B CG2 1 
ATOM   3604 C CD1 . ILE B 1 148 ? 149.833 119.473 118.814 1.00 69.05  ? 179 ILE B CD1 1 
ATOM   3605 N N   . SER B 1 149 ? 150.737 116.868 124.072 1.00 65.50  ? 180 SER B N   1 
ATOM   3606 C CA  . SER B 1 149 ? 150.307 116.731 125.455 1.00 64.02  ? 180 SER B CA  1 
ATOM   3607 C C   . SER B 1 149 ? 149.768 118.061 125.959 1.00 70.12  ? 180 SER B C   1 
ATOM   3608 O O   . SER B 1 149 ? 150.395 119.105 125.760 1.00 76.24  ? 180 SER B O   1 
ATOM   3609 C CB  . SER B 1 149 ? 151.472 116.275 126.332 1.00 64.70  ? 180 SER B CB  1 
ATOM   3610 O OG  . SER B 1 149 ? 151.976 115.025 125.904 1.00 64.64  ? 180 SER B OG  1 
ATOM   3611 N N   . ILE B 1 150 ? 148.604 118.026 126.603 1.00 69.79  ? 181 ILE B N   1 
ATOM   3612 C CA  . ILE B 1 150 ? 148.052 119.220 127.234 1.00 75.94  ? 181 ILE B CA  1 
ATOM   3613 C C   . ILE B 1 150 ? 147.969 119.015 128.740 1.00 80.76  ? 181 ILE B C   1 
ATOM   3614 O O   . ILE B 1 150 ? 147.255 118.132 129.226 1.00 79.56  ? 181 ILE B O   1 
ATOM   3615 C CB  . ILE B 1 150 ? 146.677 119.589 126.644 1.00 76.99  ? 181 ILE B CB  1 
ATOM   3616 C CG1 . ILE B 1 150 ? 146.814 119.977 125.172 1.00 76.47  ? 181 ILE B CG1 1 
ATOM   3617 C CG2 . ILE B 1 150 ? 146.029 120.720 127.427 1.00 84.82  ? 181 ILE B CG2 1 
ATOM   3618 C CD1 . ILE B 1 150 ? 147.717 121.174 124.938 1.00 81.61  ? 181 ILE B CD1 1 
ATOM   3619 N N   . ASP B 1 151 ? 148.720 119.822 129.488 1.00 87.04  ? 182 ASP B N   1 
ATOM   3620 C CA  . ASP B 1 151 ? 148.579 119.825 130.939 1.00 93.97  ? 182 ASP B CA  1 
ATOM   3621 C C   . ASP B 1 151 ? 147.970 121.135 131.420 1.00 96.37  ? 182 ASP B C   1 
ATOM   3622 O O   . ASP B 1 151 ? 147.250 121.163 132.425 1.00 96.66  ? 182 ASP B O   1 
ATOM   3623 C CB  . ASP B 1 151 ? 149.936 119.579 131.598 1.00 93.37  ? 182 ASP B CB  1 
ATOM   3624 C CG  . ASP B 1 151 ? 150.528 118.233 131.228 1.00 92.37  ? 182 ASP B CG  1 
ATOM   3625 O OD1 . ASP B 1 151 ? 149.757 117.329 130.840 1.00 86.08  ? 182 ASP B OD1 1 
ATOM   3626 O OD2 . ASP B 1 151 ? 151.764 118.079 131.319 1.00 96.64  ? 182 ASP B OD2 1 
ATOM   3627 N N   . ASN B 1 152 ? 148.244 122.226 130.711 1.00 96.86  ? 183 ASN B N   1 
ATOM   3628 C CA  . ASN B 1 152 ? 147.684 123.537 131.007 1.00 100.30 ? 183 ASN B CA  1 
ATOM   3629 C C   . ASN B 1 152 ? 146.662 123.872 129.931 1.00 100.72 ? 183 ASN B C   1 
ATOM   3630 O O   . ASN B 1 152 ? 146.945 123.725 128.737 1.00 98.81  ? 183 ASN B O   1 
ATOM   3631 C CB  . ASN B 1 152 ? 148.781 124.600 131.062 1.00 102.12 ? 183 ASN B CB  1 
ATOM   3632 C CG  . ASN B 1 152 ? 148.387 125.807 131.890 1.00 103.38 ? 183 ASN B CG  1 
ATOM   3633 O OD1 . ASN B 1 152 ? 147.306 125.844 132.479 1.00 102.27 ? 183 ASN B OD1 1 
ATOM   3634 N ND2 . ASN B 1 152 ? 149.266 126.803 131.940 1.00 105.61 ? 183 ASN B ND2 1 
ATOM   3635 N N   . ALA B 1 153 ? 145.476 124.318 130.352 1.00 100.78 ? 184 ALA B N   1 
ATOM   3636 C CA  . ALA B 1 153 ? 144.429 124.651 129.392 1.00 97.93  ? 184 ALA B CA  1 
ATOM   3637 C C   . ALA B 1 153 ? 144.671 126.001 128.728 1.00 101.16 ? 184 ALA B C   1 
ATOM   3638 O O   . ALA B 1 153 ? 144.119 126.270 127.656 1.00 99.82  ? 184 ALA B O   1 
ATOM   3639 C CB  . ALA B 1 153 ? 143.063 124.636 130.078 1.00 93.75  ? 184 ALA B CB  1 
ATOM   3640 N N   . SER B 1 154 ? 145.485 126.863 129.345 1.00 103.01 ? 185 SER B N   1 
ATOM   3641 C CA  . SER B 1 154 ? 145.767 128.168 128.755 1.00 102.78 ? 185 SER B CA  1 
ATOM   3642 C C   . SER B 1 154 ? 146.788 128.064 127.627 1.00 101.53 ? 185 SER B C   1 
ATOM   3643 O O   . SER B 1 154 ? 146.853 128.941 126.757 1.00 100.73 ? 185 SER B O   1 
ATOM   3644 C CB  . SER B 1 154 ? 146.251 129.137 129.833 1.00 101.78 ? 185 SER B CB  1 
ATOM   3645 O OG  . SER B 1 154 ? 145.249 129.355 130.811 1.00 100.15 ? 185 SER B OG  1 
ATOM   3646 N N   . LEU B 1 155 ? 147.592 127.001 127.620 1.00 98.67  ? 186 LEU B N   1 
ATOM   3647 C CA  . LEU B 1 155 ? 148.552 126.779 126.546 1.00 98.31  ? 186 LEU B CA  1 
ATOM   3648 C C   . LEU B 1 155 ? 147.970 125.991 125.381 1.00 98.23  ? 186 LEU B C   1 
ATOM   3649 O O   . LEU B 1 155 ? 148.708 125.683 124.440 1.00 98.91  ? 186 LEU B O   1 
ATOM   3650 C CB  . LEU B 1 155 ? 149.791 126.054 127.073 1.00 97.73  ? 186 LEU B CB  1 
ATOM   3651 C CG  . LEU B 1 155 ? 150.626 126.769 128.132 1.00 100.37 ? 186 LEU B CG  1 
ATOM   3652 C CD1 . LEU B 1 155 ? 151.692 125.837 128.677 1.00 102.18 ? 186 LEU B CD1 1 
ATOM   3653 C CD2 . LEU B 1 155 ? 151.258 128.019 127.547 1.00 100.60 ? 186 LEU B CD2 1 
ATOM   3654 N N   . ALA B 1 156 ? 146.681 125.647 125.425 1.00 96.97  ? 187 ALA B N   1 
ATOM   3655 C CA  . ALA B 1 156 ? 146.067 124.916 124.323 1.00 94.63  ? 187 ALA B CA  1 
ATOM   3656 C C   . ALA B 1 156 ? 145.793 125.836 123.139 1.00 96.20  ? 187 ALA B C   1 
ATOM   3657 O O   . ALA B 1 156 ? 145.746 125.387 121.989 1.00 95.76  ? 187 ALA B O   1 
ATOM   3658 C CB  . ALA B 1 156 ? 144.779 124.244 124.795 1.00 91.65  ? 187 ALA B CB  1 
ATOM   3659 N N   . GLU B 1 157 ? 145.598 127.129 123.407 1.00 97.59  ? 188 GLU B N   1 
ATOM   3660 C CA  . GLU B 1 157 ? 145.381 128.092 122.331 1.00 96.10  ? 188 GLU B CA  1 
ATOM   3661 C C   . GLU B 1 157 ? 146.687 128.406 121.608 1.00 93.01  ? 188 GLU B C   1 
ATOM   3662 O O   . GLU B 1 157 ? 146.696 128.632 120.392 1.00 91.60  ? 188 GLU B O   1 
ATOM   3663 C CB  . GLU B 1 157 ? 144.746 129.363 122.901 1.00 98.95  ? 188 GLU B CB  1 
ATOM   3664 C CG  . GLU B 1 157 ? 144.244 130.363 121.869 1.00 102.29 ? 188 GLU B CG  1 
ATOM   3665 C CD  . GLU B 1 157 ? 143.765 131.657 122.495 1.00 105.48 ? 188 GLU B CD  1 
ATOM   3666 O OE1 . GLU B 1 157 ? 143.757 131.749 123.740 1.00 104.29 ? 188 GLU B OE1 1 
ATOM   3667 O OE2 . GLU B 1 157 ? 143.395 132.582 121.743 1.00 106.87 ? 188 GLU B OE2 1 
ATOM   3668 N N   . ASN B 1 158 ? 147.803 128.412 122.343 1.00 91.50  ? 189 ASN B N   1 
ATOM   3669 C CA  . ASN B 1 158 ? 149.109 128.635 121.730 1.00 89.45  ? 189 ASN B CA  1 
ATOM   3670 C C   . ASN B 1 158 ? 149.571 127.410 120.948 1.00 89.96  ? 189 ASN B C   1 
ATOM   3671 O O   . ASN B 1 158 ? 150.192 127.540 119.887 1.00 89.59  ? 189 ASN B O   1 
ATOM   3672 C CB  . ASN B 1 158 ? 150.129 129.004 122.808 1.00 87.56  ? 189 ASN B CB  1 
ATOM   3673 C CG  . ASN B 1 158 ? 151.524 129.203 122.252 1.00 85.86  ? 189 ASN B CG  1 
ATOM   3674 O OD1 . ASN B 1 158 ? 151.706 129.805 121.194 1.00 83.54  ? 189 ASN B OD1 1 
ATOM   3675 N ND2 . ASN B 1 158 ? 152.519 128.690 122.963 1.00 87.71  ? 189 ASN B ND2 1 
ATOM   3676 N N   . LEU B 1 159 ? 149.254 126.212 121.445 1.00 90.44  ? 190 LEU B N   1 
ATOM   3677 C CA  . LEU B 1 159 ? 149.744 124.992 120.808 1.00 89.62  ? 190 LEU B CA  1 
ATOM   3678 C C   . LEU B 1 159 ? 148.913 124.620 119.589 1.00 90.91  ? 190 LEU B C   1 
ATOM   3679 O O   . LEU B 1 159 ? 149.363 123.841 118.741 1.00 89.07  ? 190 LEU B O   1 
ATOM   3680 C CB  . LEU B 1 159 ? 149.752 123.847 121.816 1.00 86.01  ? 190 LEU B CB  1 
ATOM   3681 C CG  . LEU B 1 159 ? 151.083 123.678 122.541 1.00 89.22  ? 190 LEU B CG  1 
ATOM   3682 C CD1 . LEU B 1 159 ? 151.009 122.612 123.621 1.00 90.44  ? 190 LEU B CD1 1 
ATOM   3683 C CD2 . LEU B 1 159 ? 152.200 123.373 121.552 1.00 85.23  ? 190 LEU B CD2 1 
ATOM   3684 N N   . LEU B 1 160 ? 147.697 125.156 119.487 1.00 90.25  ? 191 LEU B N   1 
ATOM   3685 C CA  . LEU B 1 160 ? 146.872 124.895 118.314 1.00 87.21  ? 191 LEU B CA  1 
ATOM   3686 C C   . LEU B 1 160 ? 147.339 125.725 117.126 1.00 85.21  ? 191 LEU B C   1 
ATOM   3687 O O   . LEU B 1 160 ? 147.129 125.344 115.971 1.00 86.42  ? 191 LEU B O   1 
ATOM   3688 C CB  . LEU B 1 160 ? 145.406 125.178 118.639 1.00 90.37  ? 191 LEU B CB  1 
ATOM   3689 C CG  . LEU B 1 160 ? 144.312 124.609 117.736 1.00 93.92  ? 191 LEU B CG  1 
ATOM   3690 C CD1 . LEU B 1 160 ? 144.563 123.146 117.397 1.00 85.23  ? 191 LEU B CD1 1 
ATOM   3691 C CD2 . LEU B 1 160 ? 142.970 124.773 118.415 1.00 94.15  ? 191 LEU B CD2 1 
ATOM   3692 N N   . ILE B 1 161 ? 147.959 126.877 117.397 1.00 86.14  ? 192 ILE B N   1 
ATOM   3693 C CA  . ILE B 1 161 ? 148.519 127.722 116.342 1.00 87.00  ? 192 ILE B CA  1 
ATOM   3694 C C   . ILE B 1 161 ? 149.763 127.073 115.740 1.00 85.53  ? 192 ILE B C   1 
ATOM   3695 O O   . ILE B 1 161 ? 149.936 127.047 114.512 1.00 87.62  ? 192 ILE B O   1 
ATOM   3696 C CB  . ILE B 1 161 ? 148.800 129.132 116.908 1.00 87.64  ? 192 ILE B CB  1 
ATOM   3697 C CG1 . ILE B 1 161 ? 147.487 129.793 117.332 1.00 92.18  ? 192 ILE B CG1 1 
ATOM   3698 C CG2 . ILE B 1 161 ? 149.511 130.040 115.908 1.00 83.77  ? 192 ILE B CG2 1 
ATOM   3699 C CD1 . ILE B 1 161 ? 147.659 131.116 118.056 1.00 88.36  ? 192 ILE B CD1 1 
ATOM   3700 N N   . GLN B 1 162 ? 150.601 126.465 116.588 1.00 81.33  ? 193 GLN B N   1 
ATOM   3701 C CA  . GLN B 1 162 ? 151.904 125.974 116.146 1.00 78.33  ? 193 GLN B CA  1 
ATOM   3702 C C   . GLN B 1 162 ? 151.796 124.659 115.381 1.00 79.28  ? 193 GLN B C   1 
ATOM   3703 O O   . GLN B 1 162 ? 152.710 124.300 114.632 1.00 81.59  ? 193 GLN B O   1 
ATOM   3704 C CB  . GLN B 1 162 ? 152.835 125.814 117.347 1.00 82.27  ? 193 GLN B CB  1 
ATOM   3705 C CG  . GLN B 1 162 ? 153.053 127.096 118.137 1.00 88.88  ? 193 GLN B CG  1 
ATOM   3706 C CD  . GLN B 1 162 ? 154.000 126.919 119.310 1.00 88.77  ? 193 GLN B CD  1 
ATOM   3707 O OE1 . GLN B 1 162 ? 154.514 125.829 119.550 1.00 88.84  ? 193 GLN B OE1 1 
ATOM   3708 N NE2 . GLN B 1 162 ? 154.225 127.995 120.054 1.00 86.23  ? 193 GLN B NE2 1 
ATOM   3709 N N   . GLU B 1 163 ? 150.681 123.936 115.535 1.00 80.66  ? 194 GLU B N   1 
ATOM   3710 C CA  . GLU B 1 163 ? 150.510 122.689 114.791 1.00 79.04  ? 194 GLU B CA  1 
ATOM   3711 C C   . GLU B 1 163 ? 149.862 122.936 113.430 1.00 77.81  ? 194 GLU B C   1 
ATOM   3712 O O   . GLU B 1 163 ? 150.159 122.229 112.458 1.00 76.35  ? 194 GLU B O   1 
ATOM   3713 C CB  . GLU B 1 163 ? 149.707 121.686 115.624 1.00 73.56  ? 194 GLU B CB  1 
ATOM   3714 C CG  . GLU B 1 163 ? 149.584 120.246 115.071 1.00 72.62  ? 194 GLU B CG  1 
ATOM   3715 C CD  . GLU B 1 163 ? 150.904 119.481 114.940 1.00 74.71  ? 194 GLU B CD  1 
ATOM   3716 O OE1 . GLU B 1 163 ? 151.629 119.650 113.937 1.00 70.70  ? 194 GLU B OE1 1 
ATOM   3717 O OE2 . GLU B 1 163 ? 151.216 118.679 115.841 1.00 73.38  ? 194 GLU B OE2 1 
ATOM   3718 N N   . VAL B 1 164 ? 148.985 123.945 113.343 1.00 78.67  ? 195 VAL B N   1 
ATOM   3719 C CA  . VAL B 1 164 ? 148.484 124.425 112.054 1.00 77.32  ? 195 VAL B CA  1 
ATOM   3720 C C   . VAL B 1 164 ? 149.614 125.085 111.262 1.00 78.88  ? 195 VAL B C   1 
ATOM   3721 O O   . VAL B 1 164 ? 149.746 124.882 110.048 1.00 80.61  ? 195 VAL B O   1 
ATOM   3722 C CB  . VAL B 1 164 ? 147.273 125.358 112.286 1.00 79.36  ? 195 VAL B CB  1 
ATOM   3723 C CG1 . VAL B 1 164 ? 146.783 126.038 111.012 1.00 79.94  ? 195 VAL B CG1 1 
ATOM   3724 C CG2 . VAL B 1 164 ? 146.123 124.555 112.863 1.00 78.34  ? 195 VAL B CG2 1 
ATOM   3725 N N   . GLN B 1 165 ? 150.536 125.756 111.964 1.00 78.58  ? 196 GLN B N   1 
ATOM   3726 C CA  . GLN B 1 165 ? 151.745 126.263 111.315 1.00 80.30  ? 196 GLN B CA  1 
ATOM   3727 C C   . GLN B 1 165 ? 152.773 125.161 111.046 1.00 80.69  ? 196 GLN B C   1 
ATOM   3728 O O   . GLN B 1 165 ? 153.750 125.392 110.326 1.00 83.54  ? 196 GLN B O   1 
ATOM   3729 C CB  . GLN B 1 165 ? 152.374 127.368 112.160 1.00 83.03  ? 196 GLN B CB  1 
ATOM   3730 C CG  . GLN B 1 165 ? 151.686 128.715 112.034 1.00 86.11  ? 196 GLN B CG  1 
ATOM   3731 C CD  . GLN B 1 165 ? 152.356 129.793 112.863 1.00 92.32  ? 196 GLN B CD  1 
ATOM   3732 O OE1 . GLN B 1 165 ? 153.543 129.703 113.179 1.00 93.90  ? 196 GLN B OE1 1 
ATOM   3733 N NE2 . GLN B 1 165 ? 151.598 130.824 113.212 1.00 91.68  ? 196 GLN B NE2 1 
ATOM   3734 N N   . PHE B 1 166 ? 152.597 123.967 111.628 1.00 76.48  ? 197 PHE B N   1 
ATOM   3735 C CA  . PHE B 1 166 ? 153.453 122.843 111.260 1.00 73.81  ? 197 PHE B CA  1 
ATOM   3736 C C   . PHE B 1 166 ? 152.896 122.078 110.068 1.00 72.76  ? 197 PHE B C   1 
ATOM   3737 O O   . PHE B 1 166 ? 153.628 121.815 109.106 1.00 73.34  ? 197 PHE B O   1 
ATOM   3738 C CB  . PHE B 1 166 ? 153.649 121.896 112.448 1.00 71.79  ? 197 PHE B CB  1 
ATOM   3739 C CG  . PHE B 1 166 ? 154.811 120.941 112.284 1.00 68.31  ? 197 PHE B CG  1 
ATOM   3740 C CD1 . PHE B 1 166 ? 154.610 119.640 111.802 1.00 69.19  ? 197 PHE B CD1 1 
ATOM   3741 C CD2 . PHE B 1 166 ? 156.105 121.348 112.607 1.00 66.94  ? 197 PHE B CD2 1 
ATOM   3742 C CE1 . PHE B 1 166 ? 155.680 118.768 111.636 1.00 67.41  ? 197 PHE B CE1 1 
ATOM   3743 C CE2 . PHE B 1 166 ? 157.185 120.476 112.453 1.00 66.35  ? 197 PHE B CE2 1 
ATOM   3744 C CZ  . PHE B 1 166 ? 156.967 119.188 111.966 1.00 66.39  ? 197 PHE B CZ  1 
ATOM   3745 N N   . LEU B 1 167 ? 151.610 121.695 110.123 1.00 73.30  ? 198 LEU B N   1 
ATOM   3746 C CA  . LEU B 1 167 ? 151.093 120.629 109.261 1.00 73.31  ? 198 LEU B CA  1 
ATOM   3747 C C   . LEU B 1 167 ? 150.847 121.103 107.833 1.00 72.58  ? 198 LEU B C   1 
ATOM   3748 O O   . LEU B 1 167 ? 150.771 120.284 106.910 1.00 70.53  ? 198 LEU B O   1 
ATOM   3749 C CB  . LEU B 1 167 ? 149.804 120.043 109.842 1.00 71.70  ? 198 LEU B CB  1 
ATOM   3750 C CG  . LEU B 1 167 ? 149.866 119.039 110.997 1.00 65.39  ? 198 LEU B CG  1 
ATOM   3751 C CD1 . LEU B 1 167 ? 148.495 118.456 111.250 1.00 60.44  ? 198 LEU B CD1 1 
ATOM   3752 C CD2 . LEU B 1 167 ? 150.848 117.927 110.719 1.00 61.92  ? 198 LEU B CD2 1 
ATOM   3753 N N   . GLN B 1 168 ? 150.720 122.414 107.631 1.00 74.55  ? 199 GLN B N   1 
ATOM   3754 C CA  . GLN B 1 168 ? 150.633 122.941 106.275 1.00 77.05  ? 199 GLN B CA  1 
ATOM   3755 C C   . GLN B 1 168 ? 152.001 122.954 105.608 1.00 72.72  ? 199 GLN B C   1 
ATOM   3756 O O   . GLN B 1 168 ? 152.118 122.716 104.400 1.00 68.16  ? 199 GLN B O   1 
ATOM   3757 C CB  . GLN B 1 168 ? 150.038 124.347 106.295 1.00 78.90  ? 199 GLN B CB  1 
ATOM   3758 C CG  . GLN B 1 168 ? 148.651 124.433 106.900 1.00 77.32  ? 199 GLN B CG  1 
ATOM   3759 C CD  . GLN B 1 168 ? 148.255 125.849 107.284 1.00 79.95  ? 199 GLN B CD  1 
ATOM   3760 O OE1 . GLN B 1 168 ? 147.095 126.113 107.596 1.00 80.94  ? 199 GLN B OE1 1 
ATOM   3761 N NE2 . GLN B 1 168 ? 149.219 126.763 107.274 1.00 78.02  ? 199 GLN B NE2 1 
ATOM   3762 N N   . GLN B 1 169 ? 153.051 123.217 106.386 1.00 73.06  ? 200 GLN B N   1 
ATOM   3763 C CA  . GLN B 1 169 ? 154.349 123.509 105.791 1.00 75.91  ? 200 GLN B CA  1 
ATOM   3764 C C   . GLN B 1 169 ? 155.224 122.265 105.698 1.00 75.43  ? 200 GLN B C   1 
ATOM   3765 O O   . GLN B 1 169 ? 155.693 121.909 104.610 1.00 76.17  ? 200 GLN B O   1 
ATOM   3766 C CB  . GLN B 1 169 ? 155.047 124.605 106.597 1.00 74.63  ? 200 GLN B CB  1 
ATOM   3767 C CG  . GLN B 1 169 ? 154.181 125.838 106.811 1.00 79.25  ? 200 GLN B CG  1 
ATOM   3768 C CD  . GLN B 1 169 ? 154.840 126.886 107.694 1.00 87.15  ? 200 GLN B CD  1 
ATOM   3769 O OE1 . GLN B 1 169 ? 156.064 126.927 107.824 1.00 92.33  ? 200 GLN B OE1 1 
ATOM   3770 N NE2 . GLN B 1 169 ? 154.026 127.741 108.304 1.00 84.62  ? 200 GLN B NE2 1 
ATOM   3771 N N   . CYS B 1 170 ? 155.444 121.581 106.816 1.00 71.11  ? 201 CYS B N   1 
ATOM   3772 C CA  . CYS B 1 170 ? 156.479 120.562 106.902 1.00 69.10  ? 201 CYS B CA  1 
ATOM   3773 C C   . CYS B 1 170 ? 156.032 119.186 106.432 1.00 67.58  ? 201 CYS B C   1 
ATOM   3774 O O   . CYS B 1 170 ? 156.886 118.332 106.176 1.00 66.31  ? 201 CYS B O   1 
ATOM   3775 C CB  . CYS B 1 170 ? 156.989 120.469 108.343 1.00 73.17  ? 201 CYS B CB  1 
ATOM   3776 S SG  . CYS B 1 170 ? 157.412 122.069 109.067 1.00 79.70  ? 201 CYS B SG  1 
ATOM   3777 N N   . THR B 1 171 ? 154.729 118.945 106.306 1.00 67.54  ? 202 THR B N   1 
ATOM   3778 C CA  . THR B 1 171 ? 154.193 117.613 106.044 1.00 60.44  ? 202 THR B CA  1 
ATOM   3779 C C   . THR B 1 171 ? 153.566 117.562 104.659 1.00 62.12  ? 202 THR B C   1 
ATOM   3780 O O   . THR B 1 171 ? 152.763 118.432 104.306 1.00 64.49  ? 202 THR B O   1 
ATOM   3781 C CB  . THR B 1 171 ? 153.167 117.226 107.103 1.00 56.78  ? 202 THR B CB  1 
ATOM   3782 O OG1 . THR B 1 171 ? 152.089 118.168 107.091 1.00 56.58  ? 202 THR B OG1 1 
ATOM   3783 C CG2 . THR B 1 171 ? 153.814 117.200 108.473 1.00 63.14  ? 202 THR B CG2 1 
ATOM   3784 N N   . THR B 1 172 ? 153.930 116.534 103.887 1.00 62.16  ? 203 THR B N   1 
ATOM   3785 C CA  . THR B 1 172 ? 153.424 116.391 102.525 1.00 59.06  ? 203 THR B CA  1 
ATOM   3786 C C   . THR B 1 172 ? 151.971 115.925 102.514 1.00 55.19  ? 203 THR B C   1 
ATOM   3787 O O   . THR B 1 172 ? 151.140 116.464 101.774 1.00 60.22  ? 203 THR B O   1 
ATOM   3788 C CB  . THR B 1 172 ? 154.307 115.414 101.749 1.00 57.41  ? 203 THR B CB  1 
ATOM   3789 O OG1 . THR B 1 172 ? 155.684 115.740 101.972 1.00 57.73  ? 203 THR B OG1 1 
ATOM   3790 C CG2 . THR B 1 172 ? 154.016 115.489 100.261 1.00 55.72  ? 203 THR B CG2 1 
ATOM   3791 N N   . TYR B 1 173 ? 151.641 114.940 103.338 1.00 49.05  ? 204 TYR B N   1 
ATOM   3792 C CA  . TYR B 1 173 ? 150.306 114.356 103.388 1.00 46.18  ? 204 TYR B CA  1 
ATOM   3793 C C   . TYR B 1 173 ? 149.786 114.439 104.817 1.00 42.44  ? 204 TYR B C   1 
ATOM   3794 O O   . TYR B 1 173 ? 149.977 113.513 105.599 1.00 45.34  ? 204 TYR B O   1 
ATOM   3795 C CB  . TYR B 1 173 ? 150.336 112.913 102.912 1.00 51.28  ? 204 TYR B CB  1 
ATOM   3796 C CG  . TYR B 1 173 ? 150.545 112.709 101.432 1.00 59.39  ? 204 TYR B CG  1 
ATOM   3797 C CD1 . TYR B 1 173 ? 149.481 112.846 100.534 1.00 61.72  ? 204 TYR B CD1 1 
ATOM   3798 C CD2 . TYR B 1 173 ? 151.802 112.353 100.934 1.00 58.99  ? 204 TYR B CD2 1 
ATOM   3799 C CE1 . TYR B 1 173 ? 149.667 112.647 99.166  1.00 58.82  ? 204 TYR B CE1 1 
ATOM   3800 C CE2 . TYR B 1 173 ? 152.002 112.149 99.569  1.00 61.04  ? 204 TYR B CE2 1 
ATOM   3801 C CZ  . TYR B 1 173 ? 150.929 112.297 98.698  1.00 60.12  ? 204 TYR B CZ  1 
ATOM   3802 O OH  . TYR B 1 173 ? 151.120 112.098 97.352  1.00 62.30  ? 204 TYR B OH  1 
ATOM   3803 N N   . SER B 1 174 ? 149.128 115.533 105.159 1.00 43.56  ? 205 SER B N   1 
ATOM   3804 C CA  . SER B 1 174 ? 148.551 115.650 106.487 1.00 45.93  ? 205 SER B CA  1 
ATOM   3805 C C   . SER B 1 174 ? 147.068 115.329 106.438 1.00 41.90  ? 205 SER B C   1 
ATOM   3806 O O   . SER B 1 174 ? 146.447 115.326 105.376 1.00 44.82  ? 205 SER B O   1 
ATOM   3807 C CB  . SER B 1 174 ? 148.759 117.052 107.062 1.00 56.85  ? 205 SER B CB  1 
ATOM   3808 O OG  . SER B 1 174 ? 148.374 118.056 106.139 1.00 62.77  ? 205 SER B OG  1 
ATOM   3809 N N   . MET B 1 175 ? 146.499 115.046 107.606 1.00 41.25  ? 206 MET B N   1 
ATOM   3810 C CA  . MET B 1 175 ? 145.067 114.792 107.696 1.00 40.38  ? 206 MET B CA  1 
ATOM   3811 C C   . MET B 1 175 ? 144.352 115.836 108.540 1.00 43.29  ? 206 MET B C   1 
ATOM   3812 O O   . MET B 1 175 ? 143.405 116.459 108.052 1.00 51.73  ? 206 MET B O   1 
ATOM   3813 C CB  . MET B 1 175 ? 144.810 113.379 108.226 1.00 41.19  ? 206 MET B CB  1 
ATOM   3814 C CG  . MET B 1 175 ? 145.218 112.308 107.234 1.00 43.70  ? 206 MET B CG  1 
ATOM   3815 S SD  . MET B 1 175 ? 145.081 110.606 107.801 1.00 62.79  ? 206 MET B SD  1 
ATOM   3816 C CE  . MET B 1 175 ? 143.580 110.684 108.763 1.00 54.05  ? 206 MET B CE  1 
ATOM   3817 N N   . GLY B 1 176 ? 144.770 116.062 109.779 1.00 42.23  ? 207 GLY B N   1 
ATOM   3818 C CA  . GLY B 1 176 ? 144.116 117.089 110.567 1.00 44.96  ? 207 GLY B CA  1 
ATOM   3819 C C   . GLY B 1 176 ? 144.448 116.964 112.033 1.00 45.17  ? 207 GLY B C   1 
ATOM   3820 O O   . GLY B 1 176 ? 145.143 116.040 112.459 1.00 49.18  ? 207 GLY B O   1 
ATOM   3821 N N   . ILE B 1 177 ? 143.930 117.913 112.805 1.00 46.47  ? 208 ILE B N   1 
ATOM   3822 C CA  . ILE B 1 177 ? 144.198 117.996 114.236 1.00 47.46  ? 208 ILE B CA  1 
ATOM   3823 C C   . ILE B 1 177 ? 142.946 117.547 114.970 1.00 47.53  ? 208 ILE B C   1 
ATOM   3824 O O   . ILE B 1 177 ? 141.870 118.125 114.787 1.00 52.76  ? 208 ILE B O   1 
ATOM   3825 C CB  . ILE B 1 177 ? 144.617 119.411 114.687 1.00 55.37  ? 208 ILE B CB  1 
ATOM   3826 C CG1 . ILE B 1 177 ? 145.950 119.893 114.086 1.00 58.61  ? 208 ILE B CG1 1 
ATOM   3827 C CG2 . ILE B 1 177 ? 144.726 119.501 116.207 1.00 58.82  ? 208 ILE B CG2 1 
ATOM   3828 C CD1 . ILE B 1 177 ? 145.870 120.712 112.811 1.00 63.49  ? 208 ILE B CD1 1 
ATOM   3829 N N   . PHE B 1 178 ? 143.076 116.515 115.793 1.00 48.93  ? 209 PHE B N   1 
ATOM   3830 C CA  . PHE B 1 178 ? 142.006 116.081 116.677 1.00 49.60  ? 209 PHE B CA  1 
ATOM   3831 C C   . PHE B 1 178 ? 142.160 116.780 118.020 1.00 52.49  ? 209 PHE B C   1 
ATOM   3832 O O   . PHE B 1 178 ? 143.245 116.786 118.604 1.00 54.94  ? 209 PHE B O   1 
ATOM   3833 C CB  . PHE B 1 178 ? 142.036 114.567 116.854 1.00 46.05  ? 209 PHE B CB  1 
ATOM   3834 C CG  . PHE B 1 178 ? 141.220 113.826 115.847 1.00 42.21  ? 209 PHE B CG  1 
ATOM   3835 C CD1 . PHE B 1 178 ? 139.852 113.642 116.042 1.00 46.20  ? 209 PHE B CD1 1 
ATOM   3836 C CD2 . PHE B 1 178 ? 141.822 113.315 114.700 1.00 43.08  ? 209 PHE B CD2 1 
ATOM   3837 C CE1 . PHE B 1 178 ? 139.088 112.949 115.105 1.00 45.70  ? 209 PHE B CE1 1 
ATOM   3838 C CE2 . PHE B 1 178 ? 141.074 112.623 113.755 1.00 46.21  ? 209 PHE B CE2 1 
ATOM   3839 C CZ  . PHE B 1 178 ? 139.704 112.441 113.961 1.00 43.51  ? 209 PHE B CZ  1 
ATOM   3840 N N   . VAL B 1 179 ? 141.083 117.390 118.493 1.00 53.03  ? 210 VAL B N   1 
ATOM   3841 C CA  . VAL B 1 179 ? 141.065 118.151 119.734 1.00 57.17  ? 210 VAL B CA  1 
ATOM   3842 C C   . VAL B 1 179 ? 140.060 117.468 120.654 1.00 61.47  ? 210 VAL B C   1 
ATOM   3843 O O   . VAL B 1 179 ? 139.008 117.020 120.189 1.00 64.53  ? 210 VAL B O   1 
ATOM   3844 C CB  . VAL B 1 179 ? 140.712 119.636 119.443 1.00 65.16  ? 210 VAL B CB  1 
ATOM   3845 C CG1 . VAL B 1 179 ? 140.451 120.466 120.689 1.00 73.42  ? 210 VAL B CG1 1 
ATOM   3846 C CG2 . VAL B 1 179 ? 141.832 120.297 118.663 1.00 63.15  ? 210 VAL B CG2 1 
ATOM   3847 N N   . ASP B 1 180 ? 140.423 117.305 121.933 1.00 62.79  ? 211 ASP B N   1 
ATOM   3848 C CA  . ASP B 1 180 ? 139.523 116.770 122.952 1.00 65.79  ? 211 ASP B CA  1 
ATOM   3849 C C   . ASP B 1 180 ? 138.321 117.682 123.176 1.00 72.98  ? 211 ASP B C   1 
ATOM   3850 O O   . ASP B 1 180 ? 138.389 118.891 122.953 1.00 81.84  ? 211 ASP B O   1 
ATOM   3851 C CB  . ASP B 1 180 ? 140.261 116.594 124.276 1.00 72.37  ? 211 ASP B CB  1 
ATOM   3852 C CG  . ASP B 1 180 ? 141.272 115.479 124.230 1.00 75.72  ? 211 ASP B CG  1 
ATOM   3853 O OD1 . ASP B 1 180 ? 141.698 115.124 123.116 1.00 74.33  ? 211 ASP B OD1 1 
ATOM   3854 O OD2 . ASP B 1 180 ? 141.643 114.959 125.302 1.00 73.59  ? 211 ASP B OD2 1 
ATOM   3855 N N   . TRP B 1 181 ? 137.219 117.077 123.639 1.00 71.54  ? 212 TRP B N   1 
ATOM   3856 C CA  . TRP B 1 181 ? 135.926 117.762 123.711 1.00 75.42  ? 212 TRP B CA  1 
ATOM   3857 C C   . TRP B 1 181 ? 135.881 118.782 124.844 1.00 81.52  ? 212 TRP B C   1 
ATOM   3858 O O   . TRP B 1 181 ? 135.076 119.720 124.816 1.00 84.92  ? 212 TRP B O   1 
ATOM   3859 C CB  . TRP B 1 181 ? 134.816 116.731 123.888 1.00 71.49  ? 212 TRP B CB  1 
ATOM   3860 C CG  . TRP B 1 181 ? 133.427 117.238 123.680 1.00 74.01  ? 212 TRP B CG  1 
ATOM   3861 C CD1 . TRP B 1 181 ? 132.584 117.728 124.633 1.00 76.63  ? 212 TRP B CD1 1 
ATOM   3862 C CD2 . TRP B 1 181 ? 132.693 117.247 122.453 1.00 76.74  ? 212 TRP B CD2 1 
ATOM   3863 N NE1 . TRP B 1 181 ? 131.381 118.072 124.071 1.00 80.88  ? 212 TRP B NE1 1 
ATOM   3864 C CE2 . TRP B 1 181 ? 131.420 117.784 122.733 1.00 80.73  ? 212 TRP B CE2 1 
ATOM   3865 C CE3 . TRP B 1 181 ? 132.993 116.864 121.140 1.00 74.32  ? 212 TRP B CE3 1 
ATOM   3866 C CZ2 . TRP B 1 181 ? 130.445 117.948 121.748 1.00 79.72  ? 212 TRP B CZ2 1 
ATOM   3867 C CZ3 . TRP B 1 181 ? 132.025 117.027 120.160 1.00 76.91  ? 212 TRP B CZ3 1 
ATOM   3868 C CH2 . TRP B 1 181 ? 130.766 117.566 120.471 1.00 78.90  ? 212 TRP B CH2 1 
ATOM   3869 N N   . GLU B 1 182 ? 136.734 118.610 125.854 1.00 79.81  ? 213 GLU B N   1 
ATOM   3870 C CA  . GLU B 1 182 ? 136.933 119.651 126.854 1.00 78.46  ? 213 GLU B CA  1 
ATOM   3871 C C   . GLU B 1 182 ? 137.684 120.838 126.259 1.00 83.26  ? 213 GLU B C   1 
ATOM   3872 O O   . GLU B 1 182 ? 137.438 121.992 126.625 1.00 85.95  ? 213 GLU B O   1 
ATOM   3873 C CB  . GLU B 1 182 ? 137.686 119.073 128.049 1.00 78.58  ? 213 GLU B CB  1 
ATOM   3874 C CG  . GLU B 1 182 ? 137.131 117.743 128.529 1.00 82.75  ? 213 GLU B CG  1 
ATOM   3875 C CD  . GLU B 1 182 ? 138.197 116.854 129.138 1.00 81.74  ? 213 GLU B CD  1 
ATOM   3876 O OE1 . GLU B 1 182 ? 139.391 117.213 129.054 1.00 80.32  ? 213 GLU B OE1 1 
ATOM   3877 O OE2 . GLU B 1 182 ? 137.841 115.798 129.701 1.00 78.42  ? 213 GLU B OE2 1 
ATOM   3878 N N   . LEU B 1 183 ? 138.610 120.568 125.335 1.00 81.58  ? 214 LEU B N   1 
ATOM   3879 C CA  . LEU B 1 183 ? 139.364 121.641 124.698 1.00 80.85  ? 214 LEU B CA  1 
ATOM   3880 C C   . LEU B 1 183 ? 138.698 122.123 123.416 1.00 83.05  ? 214 LEU B C   1 
ATOM   3881 O O   . LEU B 1 183 ? 139.075 123.170 122.879 1.00 87.35  ? 214 LEU B O   1 
ATOM   3882 C CB  . LEU B 1 183 ? 140.789 121.184 124.401 1.00 79.81  ? 214 LEU B CB  1 
ATOM   3883 C CG  . LEU B 1 183 ? 141.692 120.911 125.597 1.00 86.33  ? 214 LEU B CG  1 
ATOM   3884 C CD1 . LEU B 1 183 ? 142.994 120.287 125.130 1.00 83.67  ? 214 LEU B CD1 1 
ATOM   3885 C CD2 . LEU B 1 183 ? 141.949 122.191 126.369 1.00 86.48  ? 214 LEU B CD2 1 
ATOM   3886 N N   . TYR B 1 184 ? 137.734 121.363 122.890 1.00 82.36  ? 215 TYR B N   1 
ATOM   3887 C CA  . TYR B 1 184 ? 137.003 121.823 121.712 1.00 82.75  ? 215 TYR B CA  1 
ATOM   3888 C C   . TYR B 1 184 ? 135.992 122.896 122.085 1.00 88.85  ? 215 TYR B C   1 
ATOM   3889 O O   . TYR B 1 184 ? 135.814 123.874 121.350 1.00 92.35  ? 215 TYR B O   1 
ATOM   3890 C CB  . TYR B 1 184 ? 136.300 120.654 121.026 1.00 77.32  ? 215 TYR B CB  1 
ATOM   3891 C CG  . TYR B 1 184 ? 135.850 120.952 119.620 1.00 79.27  ? 215 TYR B CG  1 
ATOM   3892 C CD1 . TYR B 1 184 ? 136.762 120.919 118.563 1.00 76.08  ? 215 TYR B CD1 1 
ATOM   3893 C CD2 . TYR B 1 184 ? 134.514 121.271 119.345 1.00 82.59  ? 215 TYR B CD2 1 
ATOM   3894 C CE1 . TYR B 1 184 ? 136.359 121.195 117.256 1.00 77.52  ? 215 TYR B CE1 1 
ATOM   3895 C CE2 . TYR B 1 184 ? 134.096 121.550 118.042 1.00 80.36  ? 215 TYR B CE2 1 
ATOM   3896 C CZ  . TYR B 1 184 ? 135.027 121.508 117.009 1.00 78.08  ? 215 TYR B CZ  1 
ATOM   3897 O OH  . TYR B 1 184 ? 134.625 121.781 115.724 1.00 74.11  ? 215 TYR B OH  1 
ATOM   3898 N N   . LYS B 1 185 ? 135.322 122.732 123.227 1.00 87.84  ? 216 LYS B N   1 
ATOM   3899 C CA  . LYS B 1 185 ? 134.309 123.695 123.646 1.00 91.14  ? 216 LYS B CA  1 
ATOM   3900 C C   . LYS B 1 185 ? 134.947 124.942 124.246 1.00 93.40  ? 216 LYS B C   1 
ATOM   3901 O O   . LYS B 1 185 ? 134.322 126.008 124.300 1.00 95.11  ? 216 LYS B O   1 
ATOM   3902 C CB  . LYS B 1 185 ? 133.352 123.043 124.642 1.00 91.12  ? 216 LYS B CB  1 
ATOM   3903 C CG  . LYS B 1 185 ? 132.347 122.105 124.000 1.00 91.38  ? 216 LYS B CG  1 
ATOM   3904 C CD  . LYS B 1 185 ? 131.090 121.984 124.842 1.00 89.56  ? 216 LYS B CD  1 
ATOM   3905 C CE  . LYS B 1 185 ? 129.912 121.514 124.007 1.00 89.40  ? 216 LYS B CE  1 
ATOM   3906 N NZ  . LYS B 1 185 ? 128.665 121.403 124.813 1.00 88.02  ? 216 LYS B NZ  1 
ATOM   3907 N N   . GLN B 1 186 ? 136.190 124.822 124.717 1.00 93.69  ? 217 GLN B N   1 
ATOM   3908 C CA  . GLN B 1 186 ? 136.917 125.981 125.220 1.00 96.72  ? 217 GLN B CA  1 
ATOM   3909 C C   . GLN B 1 186 ? 137.393 126.874 124.079 1.00 97.45  ? 217 GLN B C   1 
ATOM   3910 O O   . GLN B 1 186 ? 137.319 128.105 124.169 1.00 101.15 ? 217 GLN B O   1 
ATOM   3911 C CB  . GLN B 1 186 ? 138.101 125.513 126.067 1.00 94.37  ? 217 GLN B CB  1 
ATOM   3912 C CG  . GLN B 1 186 ? 138.891 126.621 126.735 1.00 95.07  ? 217 GLN B CG  1 
ATOM   3913 C CD  . GLN B 1 186 ? 140.027 126.096 127.584 1.00 97.86  ? 217 GLN B CD  1 
ATOM   3914 O OE1 . GLN B 1 186 ? 140.259 124.889 127.654 1.00 98.00  ? 217 GLN B OE1 1 
ATOM   3915 N NE2 . GLN B 1 186 ? 140.749 127.003 128.234 1.00 97.77  ? 217 GLN B NE2 1 
ATOM   3916 N N   . LEU B 1 187 ? 137.851 126.270 122.983 1.00 94.79  ? 218 LEU B N   1 
ATOM   3917 C CA  . LEU B 1 187 ? 138.555 126.976 121.920 1.00 97.45  ? 218 LEU B CA  1 
ATOM   3918 C C   . LEU B 1 187 ? 137.713 127.145 120.659 1.00 99.85  ? 218 LEU B C   1 
ATOM   3919 O O   . LEU B 1 187 ? 138.238 126.978 119.556 1.00 100.21 ? 218 LEU B O   1 
ATOM   3920 C CB  . LEU B 1 187 ? 139.857 126.251 121.587 1.00 96.25  ? 218 LEU B CB  1 
ATOM   3921 C CG  . LEU B 1 187 ? 140.886 126.184 122.713 1.00 95.07  ? 218 LEU B CG  1 
ATOM   3922 C CD1 . LEU B 1 187 ? 142.026 125.260 122.330 1.00 94.37  ? 218 LEU B CD1 1 
ATOM   3923 C CD2 . LEU B 1 187 ? 141.399 127.570 123.048 1.00 95.26  ? 218 LEU B CD2 1 
ATOM   3924 N N   . GLU B 1 188 ? 136.421 127.469 120.800 1.00 101.33 ? 219 GLU B N   1 
ATOM   3925 C CA  . GLU B 1 188 ? 135.519 127.518 119.646 1.00 104.00 ? 219 GLU B CA  1 
ATOM   3926 C C   . GLU B 1 188 ? 135.759 128.748 118.771 1.00 106.22 ? 219 GLU B C   1 
ATOM   3927 O O   . GLU B 1 188 ? 135.415 128.747 117.584 1.00 105.53 ? 219 GLU B O   1 
ATOM   3928 C CB  . GLU B 1 188 ? 134.066 127.488 120.118 1.00 103.47 ? 219 GLU B CB  1 
ATOM   3929 C CG  . GLU B 1 188 ? 133.502 126.096 120.329 1.00 104.21 ? 219 GLU B CG  1 
ATOM   3930 C CD  . GLU B 1 188 ? 132.061 126.116 120.801 1.00 107.72 ? 219 GLU B CD  1 
ATOM   3931 O OE1 . GLU B 1 188 ? 131.567 127.205 121.163 1.00 111.44 ? 219 GLU B OE1 1 
ATOM   3932 O OE2 . GLU B 1 188 ? 131.421 125.043 120.809 1.00 104.39 ? 219 GLU B OE2 1 
ATOM   3933 N N   . SER B 1 189 ? 136.346 129.805 119.335 1.00 108.07 ? 220 SER B N   1 
ATOM   3934 C CA  . SER B 1 189 ? 136.635 130.998 118.545 1.00 107.33 ? 220 SER B CA  1 
ATOM   3935 C C   . SER B 1 189 ? 137.915 130.829 117.733 1.00 108.52 ? 220 SER B C   1 
ATOM   3936 O O   . SER B 1 189 ? 138.099 131.480 116.698 1.00 107.90 ? 220 SER B O   1 
ATOM   3937 C CB  . SER B 1 189 ? 136.734 132.217 119.462 1.00 105.95 ? 220 SER B CB  1 
ATOM   3938 O OG  . SER B 1 189 ? 137.623 131.973 120.537 1.00 102.35 ? 220 SER B OG  1 
ATOM   3939 N N   . VAL B 1 190 ? 138.815 129.956 118.189 1.00 108.80 ? 221 VAL B N   1 
ATOM   3940 C CA  . VAL B 1 190 ? 140.147 129.867 117.592 1.00 108.04 ? 221 VAL B CA  1 
ATOM   3941 C C   . VAL B 1 190 ? 140.140 128.909 116.402 1.00 107.19 ? 221 VAL B C   1 
ATOM   3942 O O   . VAL B 1 190 ? 140.861 129.115 115.416 1.00 106.94 ? 221 VAL B O   1 
ATOM   3943 C CB  . VAL B 1 190 ? 141.170 129.455 118.672 1.00 105.80 ? 221 VAL B CB  1 
ATOM   3944 C CG1 . VAL B 1 190 ? 142.611 129.672 118.212 1.00 102.97 ? 221 VAL B CG1 1 
ATOM   3945 C CG2 . VAL B 1 190 ? 140.913 130.222 119.966 1.00 103.16 ? 221 VAL B CG2 1 
ATOM   3946 N N   . ILE B 1 191 ? 139.307 127.862 116.471 1.00 106.01 ? 222 ILE B N   1 
ATOM   3947 C CA  . ILE B 1 191 ? 139.260 126.806 115.453 1.00 105.26 ? 222 ILE B CA  1 
ATOM   3948 C C   . ILE B 1 191 ? 138.630 127.304 114.153 1.00 106.72 ? 222 ILE B C   1 
ATOM   3949 O O   . ILE B 1 191 ? 139.137 127.025 113.055 1.00 106.47 ? 222 ILE B O   1 
ATOM   3950 C CB  . ILE B 1 191 ? 138.538 125.575 116.046 1.00 99.19  ? 222 ILE B CB  1 
ATOM   3951 C CG1 . ILE B 1 191 ? 139.402 124.982 117.158 1.00 98.97  ? 222 ILE B CG1 1 
ATOM   3952 C CG2 . ILE B 1 191 ? 138.157 124.521 115.013 1.00 89.38  ? 222 ILE B CG2 1 
ATOM   3953 C CD1 . ILE B 1 191 ? 138.720 123.962 117.988 1.00 90.28  ? 222 ILE B CD1 1 
ATOM   3954 N N   . LYS B 1 192 ? 137.580 128.126 114.256 1.00 106.39 ? 223 LYS B N   1 
ATOM   3955 C CA  . LYS B 1 192 ? 136.898 128.627 113.063 1.00 107.66 ? 223 LYS B CA  1 
ATOM   3956 C C   . LYS B 1 192 ? 137.687 129.742 112.377 1.00 108.60 ? 223 LYS B C   1 
ATOM   3957 O O   . LYS B 1 192 ? 137.453 130.041 111.200 1.00 107.35 ? 223 LYS B O   1 
ATOM   3958 C CB  . LYS B 1 192 ? 135.496 129.110 113.430 1.00 106.99 ? 223 LYS B CB  1 
ATOM   3959 C CG  . LYS B 1 192 ? 134.635 128.052 114.099 1.00 107.08 ? 223 LYS B CG  1 
ATOM   3960 C CD  . LYS B 1 192 ? 133.385 128.658 114.715 1.00 107.76 ? 223 LYS B CD  1 
ATOM   3961 C CE  . LYS B 1 192 ? 132.512 127.587 115.351 1.00 106.39 ? 223 LYS B CE  1 
ATOM   3962 N NZ  . LYS B 1 192 ? 131.323 128.166 116.035 1.00 103.62 ? 223 LYS B NZ  1 
ATOM   3963 N N   . ASP B 1 193 ? 138.631 130.362 113.091 1.00 108.97 ? 224 ASP B N   1 
ATOM   3964 C CA  . ASP B 1 193 ? 139.464 131.389 112.476 1.00 110.23 ? 224 ASP B CA  1 
ATOM   3965 C C   . ASP B 1 193 ? 140.762 130.805 111.923 1.00 109.27 ? 224 ASP B C   1 
ATOM   3966 O O   . ASP B 1 193 ? 141.439 131.449 111.113 1.00 109.89 ? 224 ASP B O   1 
ATOM   3967 C CB  . ASP B 1 193 ? 139.759 132.494 113.489 1.00 110.94 ? 224 ASP B CB  1 
ATOM   3968 C CG  . ASP B 1 193 ? 138.501 133.183 113.981 1.00 113.21 ? 224 ASP B CG  1 
ATOM   3969 O OD1 . ASP B 1 193 ? 137.428 132.969 113.378 1.00 112.83 ? 224 ASP B OD1 1 
ATOM   3970 O OD2 . ASP B 1 193 ? 138.583 133.939 114.971 1.00 115.28 ? 224 ASP B OD2 1 
ATOM   3971 N N   . LEU B 1 194 ? 141.132 129.594 112.351 1.00 106.64 ? 225 LEU B N   1 
ATOM   3972 C CA  . LEU B 1 194 ? 142.380 128.996 111.879 1.00 104.67 ? 225 LEU B CA  1 
ATOM   3973 C C   . LEU B 1 194 ? 142.225 128.399 110.485 1.00 103.69 ? 225 LEU B C   1 
ATOM   3974 O O   . LEU B 1 194 ? 143.216 128.286 109.749 1.00 102.47 ? 225 LEU B O   1 
ATOM   3975 C CB  . LEU B 1 194 ? 142.869 127.936 112.865 1.00 102.53 ? 225 LEU B CB  1 
ATOM   3976 C CG  . LEU B 1 194 ? 143.839 128.429 113.942 1.00 101.01 ? 225 LEU B CG  1 
ATOM   3977 C CD1 . LEU B 1 194 ? 143.890 127.452 115.106 1.00 97.73  ? 225 LEU B CD1 1 
ATOM   3978 C CD2 . LEU B 1 194 ? 145.227 128.650 113.362 1.00 94.75  ? 225 LEU B CD2 1 
ATOM   3979 N N   . GLU B 1 195 ? 140.988 127.993 110.133 1.00 103.79 ? 226 GLU B N   1 
ATOM   3980 C CA  . GLU B 1 195 ? 140.538 127.529 108.802 1.00 103.80 ? 226 GLU B CA  1 
ATOM   3981 C C   . GLU B 1 195 ? 141.284 126.285 108.308 1.00 96.82  ? 226 GLU B C   1 
ATOM   3982 O O   . GLU B 1 195 ? 141.605 126.168 107.125 1.00 96.77  ? 226 GLU B O   1 
ATOM   3983 C CB  . GLU B 1 195 ? 140.598 128.647 107.753 1.00 106.36 ? 226 GLU B CB  1 
ATOM   3984 C CG  . GLU B 1 195 ? 139.620 129.783 107.997 1.00 107.99 ? 226 GLU B CG  1 
ATOM   3985 C CD  . GLU B 1 195 ? 139.866 130.970 107.088 1.00 111.13 ? 226 GLU B CD  1 
ATOM   3986 O OE1 . GLU B 1 195 ? 140.808 130.911 106.271 1.00 111.77 ? 226 GLU B OE1 1 
ATOM   3987 O OE2 . GLU B 1 195 ? 139.113 131.962 107.187 1.00 113.06 ? 226 GLU B OE2 1 
ATOM   3988 N N   . TYR B 1 196 ? 141.566 125.357 109.217 1.00 91.40  ? 227 TYR B N   1 
ATOM   3989 C CA  . TYR B 1 196 ? 142.136 124.063 108.875 1.00 83.64  ? 227 TYR B CA  1 
ATOM   3990 C C   . TYR B 1 196 ? 141.155 122.983 109.308 1.00 78.03  ? 227 TYR B C   1 
ATOM   3991 O O   . TYR B 1 196 ? 140.154 123.256 109.976 1.00 81.09  ? 227 TYR B O   1 
ATOM   3992 C CB  . TYR B 1 196 ? 143.512 123.860 109.534 1.00 81.46  ? 227 TYR B CB  1 
ATOM   3993 C CG  . TYR B 1 196 ? 144.441 122.908 108.802 1.00 76.20  ? 227 TYR B CG  1 
ATOM   3994 C CD1 . TYR B 1 196 ? 144.834 123.155 107.483 1.00 78.25  ? 227 TYR B CD1 1 
ATOM   3995 C CD2 . TYR B 1 196 ? 144.900 121.750 109.430 1.00 70.44  ? 227 TYR B CD2 1 
ATOM   3996 C CE1 . TYR B 1 196 ? 145.683 122.269 106.810 1.00 76.68  ? 227 TYR B CE1 1 
ATOM   3997 C CE2 . TYR B 1 196 ? 145.748 120.861 108.774 1.00 70.70  ? 227 TYR B CE2 1 
ATOM   3998 C CZ  . TYR B 1 196 ? 146.131 121.129 107.468 1.00 74.77  ? 227 TYR B CZ  1 
ATOM   3999 O OH  . TYR B 1 196 ? 146.966 120.250 106.819 1.00 71.43  ? 227 TYR B OH  1 
ATOM   4000 N N   . ASN B 1 197 ? 141.440 121.745 108.902 1.00 71.92  ? 228 ASN B N   1 
ATOM   4001 C CA  . ASN B 1 197 ? 140.631 120.585 109.265 1.00 66.16  ? 228 ASN B CA  1 
ATOM   4002 C C   . ASN B 1 197 ? 140.915 120.236 110.720 1.00 63.33  ? 228 ASN B C   1 
ATOM   4003 O O   . ASN B 1 197 ? 141.820 119.472 111.048 1.00 62.78  ? 228 ASN B O   1 
ATOM   4004 C CB  . ASN B 1 197 ? 140.936 119.414 108.344 1.00 61.65  ? 228 ASN B CB  1 
ATOM   4005 C CG  . ASN B 1 197 ? 140.806 119.771 106.884 1.00 65.25  ? 228 ASN B CG  1 
ATOM   4006 O OD1 . ASN B 1 197 ? 141.712 119.524 106.093 1.00 65.16  ? 228 ASN B OD1 1 
ATOM   4007 N ND2 . ASN B 1 197 ? 139.671 120.350 106.515 1.00 67.76  ? 228 ASN B ND2 1 
ATOM   4008 N N   . ILE B 1 198 ? 140.133 120.826 111.613 1.00 63.75  ? 229 ILE B N   1 
ATOM   4009 C CA  . ILE B 1 198 ? 140.235 120.532 113.036 1.00 63.67  ? 229 ILE B CA  1 
ATOM   4010 C C   . ILE B 1 198 ? 138.927 119.884 113.472 1.00 64.19  ? 229 ILE B C   1 
ATOM   4011 O O   . ILE B 1 198 ? 137.857 120.488 113.364 1.00 68.01  ? 229 ILE B O   1 
ATOM   4012 C CB  . ILE B 1 198 ? 140.543 121.791 113.852 1.00 65.78  ? 229 ILE B CB  1 
ATOM   4013 C CG1 . ILE B 1 198 ? 141.923 122.337 113.491 1.00 68.08  ? 229 ILE B CG1 1 
ATOM   4014 C CG2 . ILE B 1 198 ? 140.469 121.498 115.328 1.00 64.25  ? 229 ILE B CG2 1 
ATOM   4015 C CD1 . ILE B 1 198 ? 142.180 123.727 114.018 1.00 79.72  ? 229 ILE B CD1 1 
ATOM   4016 N N   . TRP B 1 199 ? 139.013 118.652 113.971 1.00 58.07  ? 230 TRP B N   1 
ATOM   4017 C CA  . TRP B 1 199 ? 137.857 117.850 114.311 1.00 53.65  ? 230 TRP B CA  1 
ATOM   4018 C C   . TRP B 1 199 ? 137.820 117.574 115.807 1.00 57.58  ? 230 TRP B C   1 
ATOM   4019 O O   . TRP B 1 199 ? 138.878 117.454 116.430 1.00 60.83  ? 230 TRP B O   1 
ATOM   4020 C CB  . TRP B 1 199 ? 137.896 116.525 113.558 1.00 50.98  ? 230 TRP B CB  1 
ATOM   4021 C CG  . TRP B 1 199 ? 138.006 116.685 112.097 1.00 54.29  ? 230 TRP B CG  1 
ATOM   4022 C CD1 . TRP B 1 199 ? 137.199 117.426 111.292 1.00 58.25  ? 230 TRP B CD1 1 
ATOM   4023 C CD2 . TRP B 1 199 ? 138.983 116.086 111.248 1.00 53.82  ? 230 TRP B CD2 1 
ATOM   4024 N NE1 . TRP B 1 199 ? 137.610 117.324 109.988 1.00 60.83  ? 230 TRP B NE1 1 
ATOM   4025 C CE2 . TRP B 1 199 ? 138.708 116.509 109.935 1.00 56.55  ? 230 TRP B CE2 1 
ATOM   4026 C CE3 . TRP B 1 199 ? 140.067 115.230 111.471 1.00 52.40  ? 230 TRP B CE3 1 
ATOM   4027 C CZ2 . TRP B 1 199 ? 139.471 116.100 108.847 1.00 54.31  ? 230 TRP B CZ2 1 
ATOM   4028 C CZ3 . TRP B 1 199 ? 140.829 114.828 110.390 1.00 52.47  ? 230 TRP B CZ3 1 
ATOM   4029 C CH2 . TRP B 1 199 ? 140.528 115.265 109.094 1.00 54.24  ? 230 TRP B CH2 1 
ATOM   4030 N N   . PRO B 1 200 ? 136.640 117.469 116.415 1.00 60.12  ? 231 PRO B N   1 
ATOM   4031 C CA  . PRO B 1 200 ? 136.586 117.105 117.832 1.00 59.69  ? 231 PRO B CA  1 
ATOM   4032 C C   . PRO B 1 200 ? 136.710 115.608 118.062 1.00 58.53  ? 231 PRO B C   1 
ATOM   4033 O O   . PRO B 1 200 ? 136.182 114.783 117.314 1.00 57.67  ? 231 PRO B O   1 
ATOM   4034 C CB  . PRO B 1 200 ? 135.211 117.617 118.277 1.00 63.84  ? 231 PRO B CB  1 
ATOM   4035 C CG  . PRO B 1 200 ? 134.390 117.598 117.054 1.00 65.72  ? 231 PRO B CG  1 
ATOM   4036 C CD  . PRO B 1 200 ? 135.323 117.914 115.919 1.00 64.78  ? 231 PRO B CD  1 
ATOM   4037 N N   . ILE B 1 201 ? 137.454 115.265 119.108 1.00 62.07  ? 232 ILE B N   1 
ATOM   4038 C CA  . ILE B 1 201 ? 137.351 113.950 119.732 1.00 60.11  ? 232 ILE B CA  1 
ATOM   4039 C C   . ILE B 1 201 ? 136.045 114.015 120.514 1.00 63.33  ? 232 ILE B C   1 
ATOM   4040 O O   . ILE B 1 201 ? 135.748 115.072 121.089 1.00 69.91  ? 232 ILE B O   1 
ATOM   4041 C CB  . ILE B 1 201 ? 138.584 113.648 120.606 1.00 58.38  ? 232 ILE B CB  1 
ATOM   4042 C CG1 . ILE B 1 201 ? 139.825 113.566 119.717 1.00 52.97  ? 232 ILE B CG1 1 
ATOM   4043 C CG2 . ILE B 1 201 ? 138.426 112.364 121.432 1.00 56.43  ? 232 ILE B CG2 1 
ATOM   4044 C CD1 . ILE B 1 201 ? 141.114 113.190 120.412 1.00 51.75  ? 232 ILE B CD1 1 
ATOM   4045 N N   . PRO B 1 202 ? 135.205 112.971 120.498 1.00 55.44  ? 233 PRO B N   1 
ATOM   4046 C CA  . PRO B 1 202 ? 134.014 112.954 121.357 1.00 58.58  ? 233 PRO B CA  1 
ATOM   4047 C C   . PRO B 1 202 ? 134.363 112.866 122.836 1.00 60.64  ? 233 PRO B C   1 
ATOM   4048 O O   . PRO B 1 202 ? 135.470 112.474 123.215 1.00 58.28  ? 233 PRO B O   1 
ATOM   4049 C CB  . PRO B 1 202 ? 133.263 111.701 120.894 1.00 58.13  ? 233 PRO B CB  1 
ATOM   4050 C CG  . PRO B 1 202 ? 133.747 111.467 119.516 1.00 56.76  ? 233 PRO B CG  1 
ATOM   4051 C CD  . PRO B 1 202 ? 135.181 111.872 119.524 1.00 53.37  ? 233 PRO B CD  1 
ATOM   4052 N N   . GLY B 1 203 ? 133.401 113.264 123.666 1.00 64.11  ? 234 GLY B N   1 
ATOM   4053 C CA  . GLY B 1 203 ? 133.648 113.368 125.089 1.00 61.56  ? 234 GLY B CA  1 
ATOM   4054 C C   . GLY B 1 203 ? 133.700 112.017 125.775 1.00 56.93  ? 234 GLY B C   1 
ATOM   4055 O O   . GLY B 1 203 ? 132.964 111.089 125.445 1.00 57.50  ? 234 GLY B O   1 
ATOM   4056 N N   . THR B 1 204 ? 134.608 111.915 126.740 1.00 53.91  ? 235 THR B N   1 
ATOM   4057 C CA  . THR B 1 204 ? 134.777 110.705 127.525 1.00 54.35  ? 235 THR B CA  1 
ATOM   4058 C C   . THR B 1 204 ? 133.761 110.592 128.644 1.00 58.41  ? 235 THR B C   1 
ATOM   4059 O O   . THR B 1 204 ? 133.612 109.511 129.217 1.00 58.62  ? 235 THR B O   1 
ATOM   4060 C CB  . THR B 1 204 ? 136.184 110.648 128.109 1.00 52.28  ? 235 THR B CB  1 
ATOM   4061 O OG1 . THR B 1 204 ? 136.336 111.687 129.081 1.00 61.45  ? 235 THR B OG1 1 
ATOM   4062 C CG2 . THR B 1 204 ? 137.202 110.845 127.011 1.00 52.09  ? 235 THR B CG2 1 
ATOM   4063 N N   . ARG B 1 205 ? 133.022 111.662 128.936 1.00 56.99  ? 236 ARG B N   1 
ATOM   4064 C CA  . ARG B 1 205 ? 131.966 111.640 129.935 1.00 55.40  ? 236 ARG B CA  1 
ATOM   4065 C C   . ARG B 1 205 ? 130.684 110.978 129.444 1.00 55.32  ? 236 ARG B C   1 
ATOM   4066 O O   . ARG B 1 205 ? 129.774 110.772 130.243 1.00 57.62  ? 236 ARG B O   1 
ATOM   4067 C CB  . ARG B 1 205 ? 131.652 113.060 130.402 1.00 59.76  ? 236 ARG B CB  1 
ATOM   4068 C CG  . ARG B 1 205 ? 132.780 113.745 131.142 1.00 63.03  ? 236 ARG B CG  1 
ATOM   4069 C CD  . ARG B 1 205 ? 132.409 115.185 131.441 1.00 68.79  ? 236 ARG B CD  1 
ATOM   4070 N NE  . ARG B 1 205 ? 133.572 116.061 131.460 1.00 71.49  ? 236 ARG B NE  1 
ATOM   4071 C CZ  . ARG B 1 205 ? 133.530 117.361 131.204 1.00 73.04  ? 236 ARG B CZ  1 
ATOM   4072 N NH1 . ARG B 1 205 ? 132.396 117.969 130.900 1.00 74.27  ? 236 ARG B NH1 1 
ATOM   4073 N NH2 . ARG B 1 205 ? 134.654 118.069 131.258 1.00 75.19  ? 236 ARG B NH2 1 
ATOM   4074 N N   . ALA B 1 206 ? 130.574 110.647 128.162 1.00 55.36  ? 237 ALA B N   1 
ATOM   4075 C CA  . ALA B 1 206 ? 129.525 109.758 127.693 1.00 53.96  ? 237 ALA B CA  1 
ATOM   4076 C C   . ALA B 1 206 ? 129.829 108.300 128.000 1.00 53.12  ? 237 ALA B C   1 
ATOM   4077 O O   . ALA B 1 206 ? 128.915 107.473 127.987 1.00 53.66  ? 237 ALA B O   1 
ATOM   4078 C CB  . ALA B 1 206 ? 129.309 109.938 126.189 1.00 52.10  ? 237 ALA B CB  1 
ATOM   4079 N N   . HIS B 1 207 ? 131.091 107.969 128.284 1.00 52.03  ? 238 HIS B N   1 
ATOM   4080 C CA  . HIS B 1 207 ? 131.483 106.628 128.681 1.00 53.60  ? 238 HIS B CA  1 
ATOM   4081 C C   . HIS B 1 207 ? 131.619 106.459 130.184 1.00 53.08  ? 238 HIS B C   1 
ATOM   4082 O O   . HIS B 1 207 ? 131.580 105.324 130.665 1.00 54.18  ? 238 HIS B O   1 
ATOM   4083 C CB  . HIS B 1 207 ? 132.821 106.247 128.030 1.00 54.05  ? 238 HIS B CB  1 
ATOM   4084 C CG  . HIS B 1 207 ? 132.760 106.129 126.541 1.00 52.45  ? 238 HIS B CG  1 
ATOM   4085 N ND1 . HIS B 1 207 ? 132.618 104.921 125.896 1.00 51.52  ? 238 HIS B ND1 1 
ATOM   4086 C CD2 . HIS B 1 207 ? 132.820 107.069 125.569 1.00 54.00  ? 238 HIS B CD2 1 
ATOM   4087 C CE1 . HIS B 1 207 ? 132.592 105.121 124.591 1.00 52.15  ? 238 HIS B CE1 1 
ATOM   4088 N NE2 . HIS B 1 207 ? 132.713 106.417 124.367 1.00 56.70  ? 238 HIS B NE2 1 
ATOM   4089 N N   . LEU B 1 208 ? 131.777 107.548 130.933 1.00 53.12  ? 239 LEU B N   1 
ATOM   4090 C CA  . LEU B 1 208 ? 132.006 107.486 132.369 1.00 51.03  ? 239 LEU B CA  1 
ATOM   4091 C C   . LEU B 1 208 ? 130.769 107.804 133.190 1.00 50.27  ? 239 LEU B C   1 
ATOM   4092 O O   . LEU B 1 208 ? 130.496 107.109 134.167 1.00 51.64  ? 239 LEU B O   1 
ATOM   4093 C CB  . LEU B 1 208 ? 133.139 108.442 132.764 1.00 53.35  ? 239 LEU B CB  1 
ATOM   4094 C CG  . LEU B 1 208 ? 134.525 108.171 132.185 1.00 53.64  ? 239 LEU B CG  1 
ATOM   4095 C CD1 . LEU B 1 208 ? 135.544 109.107 132.801 1.00 50.18  ? 239 LEU B CD1 1 
ATOM   4096 C CD2 . LEU B 1 208 ? 134.927 106.724 132.397 1.00 54.10  ? 239 LEU B CD2 1 
ATOM   4097 N N   . PHE B 1 209 ? 130.026 108.850 132.828 1.00 50.49  ? 240 PHE B N   1 
ATOM   4098 C CA  . PHE B 1 209 ? 128.882 109.272 133.639 1.00 47.95  ? 240 PHE B CA  1 
ATOM   4099 C C   . PHE B 1 209 ? 127.651 108.357 133.560 1.00 49.98  ? 240 PHE B C   1 
ATOM   4100 O O   . PHE B 1 209 ? 126.885 108.352 134.539 1.00 55.60  ? 240 PHE B O   1 
ATOM   4101 C CB  . PHE B 1 209 ? 128.490 110.723 133.311 1.00 50.93  ? 240 PHE B CB  1 
ATOM   4102 C CG  . PHE B 1 209 ? 129.349 111.787 133.973 1.00 56.93  ? 240 PHE B CG  1 
ATOM   4103 C CD1 . PHE B 1 209 ? 130.449 111.464 134.779 1.00 54.31  ? 240 PHE B CD1 1 
ATOM   4104 C CD2 . PHE B 1 209 ? 129.044 113.132 133.764 1.00 64.99  ? 240 PHE B CD2 1 
ATOM   4105 C CE1 . PHE B 1 209 ? 131.229 112.459 135.355 1.00 54.27  ? 240 PHE B CE1 1 
ATOM   4106 C CE2 . PHE B 1 209 ? 129.812 114.138 134.344 1.00 64.08  ? 240 PHE B CE2 1 
ATOM   4107 C CZ  . PHE B 1 209 ? 130.901 113.797 135.143 1.00 58.83  ? 240 PHE B CZ  1 
ATOM   4108 N N   . PRO B 1 210 ? 127.352 107.620 132.465 1.00 48.46  ? 241 PRO B N   1 
ATOM   4109 C CA  . PRO B 1 210 ? 126.480 106.443 132.648 1.00 47.07  ? 241 PRO B CA  1 
ATOM   4110 C C   . PRO B 1 210 ? 127.055 105.348 133.527 1.00 48.76  ? 241 PRO B C   1 
ATOM   4111 O O   . PRO B 1 210 ? 126.283 104.624 134.165 1.00 56.08  ? 241 PRO B O   1 
ATOM   4112 C CB  . PRO B 1 210 ? 126.258 105.952 131.216 1.00 50.48  ? 241 PRO B CB  1 
ATOM   4113 C CG  . PRO B 1 210 ? 126.252 107.155 130.442 1.00 55.52  ? 241 PRO B CG  1 
ATOM   4114 C CD  . PRO B 1 210 ? 127.303 108.031 131.041 1.00 54.82  ? 241 PRO B CD  1 
ATOM   4115 N N   . LYS B 1 211 ? 128.376 105.176 133.569 1.00 48.90  ? 242 LYS B N   1 
ATOM   4116 C CA  . LYS B 1 211 ? 128.939 104.113 134.393 1.00 48.30  ? 242 LYS B CA  1 
ATOM   4117 C C   . LYS B 1 211 ? 129.193 104.588 135.818 1.00 46.72  ? 242 LYS B C   1 
ATOM   4118 O O   . LYS B 1 211 ? 129.450 103.770 136.706 1.00 48.41  ? 242 LYS B O   1 
ATOM   4119 C CB  . LYS B 1 211 ? 130.220 103.583 133.758 1.00 49.79  ? 242 LYS B CB  1 
ATOM   4120 C CG  . LYS B 1 211 ? 129.990 102.928 132.416 1.00 49.86  ? 242 LYS B CG  1 
ATOM   4121 C CD  . LYS B 1 211 ? 131.104 101.983 132.051 1.00 50.50  ? 242 LYS B CD  1 
ATOM   4122 C CE  . LYS B 1 211 ? 130.835 101.357 130.700 1.00 50.16  ? 242 LYS B CE  1 
ATOM   4123 N NZ  . LYS B 1 211 ? 129.467 100.781 130.618 1.00 52.86  ? 242 LYS B NZ  1 
ATOM   4124 N N   . VAL B 1 212 ? 129.164 105.904 136.053 1.00 47.52  ? 243 VAL B N   1 
ATOM   4125 C CA  . VAL B 1 212 ? 129.073 106.407 137.424 1.00 46.76  ? 243 VAL B CA  1 
ATOM   4126 C C   . VAL B 1 212 ? 127.694 106.097 137.988 1.00 44.97  ? 243 VAL B C   1 
ATOM   4127 O O   . VAL B 1 212 ? 127.561 105.522 139.076 1.00 46.06  ? 243 VAL B O   1 
ATOM   4128 C CB  . VAL B 1 212 ? 129.387 107.921 137.472 1.00 44.86  ? 243 VAL B CB  1 
ATOM   4129 C CG1 . VAL B 1 212 ? 128.928 108.559 138.766 1.00 42.65  ? 243 VAL B CG1 1 
ATOM   4130 C CG2 . VAL B 1 212 ? 130.860 108.181 137.337 1.00 42.15  ? 243 VAL B CG2 1 
ATOM   4131 N N   . ALA B 1 213 ? 126.650 106.396 137.211 1.00 43.63  ? 244 ALA B N   1 
ATOM   4132 C CA  . ALA B 1 213 ? 125.286 106.338 137.721 1.00 44.90  ? 244 ALA B CA  1 
ATOM   4133 C C   . ALA B 1 213 ? 124.742 104.916 137.735 1.00 46.25  ? 244 ALA B C   1 
ATOM   4134 O O   . ALA B 1 213 ? 123.725 104.649 138.381 1.00 50.57  ? 244 ALA B O   1 
ATOM   4135 C CB  . ALA B 1 213 ? 124.383 107.245 136.891 1.00 50.67  ? 244 ALA B CB  1 
ATOM   4136 N N   . HIS B 1 214 ? 125.383 103.995 137.015 1.00 44.59  ? 245 HIS B N   1 
ATOM   4137 C CA  . HIS B 1 214 ? 124.981 102.596 137.120 1.00 44.37  ? 245 HIS B CA  1 
ATOM   4138 C C   . HIS B 1 214 ? 125.691 101.903 138.272 1.00 45.82  ? 245 HIS B C   1 
ATOM   4139 O O   . HIS B 1 214 ? 125.176 100.928 138.830 1.00 50.86  ? 245 HIS B O   1 
ATOM   4140 C CB  . HIS B 1 214 ? 125.237 101.857 135.812 1.00 45.47  ? 245 HIS B CB  1 
ATOM   4141 C CG  . HIS B 1 214 ? 124.563 100.525 135.743 1.00 47.20  ? 245 HIS B CG  1 
ATOM   4142 N ND1 . HIS B 1 214 ? 123.198 100.388 135.631 1.00 51.83  ? 245 HIS B ND1 1 
ATOM   4143 C CD2 . HIS B 1 214 ? 125.064 99.269  135.796 1.00 49.15  ? 245 HIS B CD2 1 
ATOM   4144 C CE1 . HIS B 1 214 ? 122.887 99.105  135.605 1.00 54.23  ? 245 HIS B CE1 1 
ATOM   4145 N NE2 . HIS B 1 214 ? 124.002 98.405  135.703 1.00 51.76  ? 245 HIS B NE2 1 
ATOM   4146 N N   . LEU B 1 215 ? 126.879 102.388 138.649 1.00 45.21  ? 246 LEU B N   1 
ATOM   4147 C CA  . LEU B 1 215 ? 127.519 101.867 139.853 1.00 45.10  ? 246 LEU B CA  1 
ATOM   4148 C C   . LEU B 1 215 ? 126.856 102.409 141.105 1.00 48.38  ? 246 LEU B C   1 
ATOM   4149 O O   . LEU B 1 215 ? 126.945 101.795 142.174 1.00 46.52  ? 246 LEU B O   1 
ATOM   4150 C CB  . LEU B 1 215 ? 129.006 102.202 139.894 1.00 44.79  ? 246 LEU B CB  1 
ATOM   4151 C CG  . LEU B 1 215 ? 129.980 101.390 139.059 1.00 43.98  ? 246 LEU B CG  1 
ATOM   4152 C CD1 . LEU B 1 215 ? 131.361 101.899 139.338 1.00 46.17  ? 246 LEU B CD1 1 
ATOM   4153 C CD2 . LEU B 1 215 ? 129.864 99.946  139.382 1.00 44.89  ? 246 LEU B CD2 1 
ATOM   4154 N N   . LEU B 1 216 ? 126.229 103.583 141.004 1.00 47.99  ? 247 LEU B N   1 
ATOM   4155 C CA  . LEU B 1 216 ? 125.463 104.106 142.122 1.00 41.50  ? 247 LEU B CA  1 
ATOM   4156 C C   . LEU B 1 216 ? 124.173 103.330 142.319 1.00 46.19  ? 247 LEU B C   1 
ATOM   4157 O O   . LEU B 1 216 ? 123.812 103.045 143.456 1.00 51.87  ? 247 LEU B O   1 
ATOM   4158 C CB  . LEU B 1 216 ? 125.162 105.587 141.921 1.00 38.51  ? 247 LEU B CB  1 
ATOM   4159 C CG  . LEU B 1 216 ? 126.288 106.562 142.246 1.00 41.23  ? 247 LEU B CG  1 
ATOM   4160 C CD1 . LEU B 1 216 ? 125.859 107.980 141.930 1.00 47.33  ? 247 LEU B CD1 1 
ATOM   4161 C CD2 . LEU B 1 216 ? 126.684 106.434 143.699 1.00 42.96  ? 247 LEU B CD2 1 
ATOM   4162 N N   . HIS B 1 217 ? 123.522 102.910 141.225 1.00 46.73  ? 248 HIS B N   1 
ATOM   4163 C CA  . HIS B 1 217 ? 122.119 102.486 141.254 1.00 47.84  ? 248 HIS B CA  1 
ATOM   4164 C C   . HIS B 1 217 ? 121.938 101.110 141.896 1.00 47.80  ? 248 HIS B C   1 
ATOM   4165 O O   . HIS B 1 217 ? 120.896 100.833 142.502 1.00 52.58  ? 248 HIS B O   1 
ATOM   4166 C CB  . HIS B 1 217 ? 121.561 102.511 139.825 1.00 53.25  ? 248 HIS B CB  1 
ATOM   4167 C CG  . HIS B 1 217 ? 120.146 102.034 139.699 1.00 59.21  ? 248 HIS B CG  1 
ATOM   4168 N ND1 . HIS B 1 217 ? 119.826 100.760 139.283 1.00 58.51  ? 248 HIS B ND1 1 
ATOM   4169 C CD2 . HIS B 1 217 ? 118.969 102.658 139.936 1.00 60.30  ? 248 HIS B CD2 1 
ATOM   4170 C CE1 . HIS B 1 217 ? 118.513 100.620 139.270 1.00 56.34  ? 248 HIS B CE1 1 
ATOM   4171 N NE2 . HIS B 1 217 ? 117.970 101.758 139.661 1.00 55.30  ? 248 HIS B NE2 1 
ATOM   4172 N N   . GLN B 1 218 ? 122.959 100.264 141.845 1.00 42.72  ? 249 GLN B N   1 
ATOM   4173 C CA  . GLN B 1 218 ? 122.886 98.979  142.522 1.00 45.47  ? 249 GLN B CA  1 
ATOM   4174 C C   . GLN B 1 218 ? 123.876 98.853  143.675 1.00 46.08  ? 249 GLN B C   1 
ATOM   4175 O O   . GLN B 1 218 ? 124.201 97.731  144.076 1.00 48.46  ? 249 GLN B O   1 
ATOM   4176 C CB  . GLN B 1 218 ? 123.071 97.844  141.520 1.00 49.15  ? 249 GLN B CB  1 
ATOM   4177 C CG  . GLN B 1 218 ? 121.910 97.730  140.555 1.00 53.86  ? 249 GLN B CG  1 
ATOM   4178 C CD  . GLN B 1 218 ? 122.025 96.543  139.632 1.00 62.43  ? 249 GLN B CD  1 
ATOM   4179 O OE1 . GLN B 1 218 ? 123.010 95.810  139.665 1.00 63.42  ? 249 GLN B OE1 1 
ATOM   4180 N NE2 . GLN B 1 218 ? 121.010 96.341  138.804 1.00 63.32  ? 249 GLN B NE2 1 
ATOM   4181 N N   . MET B 1 219 ? 124.360 99.974  144.207 1.00 42.19  ? 250 MET B N   1 
ATOM   4182 C CA  . MET B 1 219 ? 125.147 99.979  145.430 1.00 38.50  ? 250 MET B CA  1 
ATOM   4183 C C   . MET B 1 219 ? 124.276 99.619  146.632 1.00 39.12  ? 250 MET B C   1 
ATOM   4184 O O   . MET B 1 219 ? 123.177 100.147 146.768 1.00 45.68  ? 250 MET B O   1 
ATOM   4185 C CB  . MET B 1 219 ? 125.750 101.358 145.647 1.00 39.89  ? 250 MET B CB  1 
ATOM   4186 C CG  . MET B 1 219 ? 126.644 101.462 146.849 1.00 44.14  ? 250 MET B CG  1 
ATOM   4187 S SD  . MET B 1 219 ? 127.391 103.075 147.009 1.00 46.51  ? 250 MET B SD  1 
ATOM   4188 C CE  . MET B 1 219 ? 128.249 102.842 148.552 1.00 33.12  ? 250 MET B CE  1 
ATOM   4189 N N   . PRO B 1 220 ? 124.727 98.702  147.495 1.00 34.94  ? 251 PRO B N   1 
ATOM   4190 C CA  . PRO B 1 220 ? 123.972 98.399  148.722 1.00 36.58  ? 251 PRO B CA  1 
ATOM   4191 C C   . PRO B 1 220 ? 124.012 99.544  149.725 1.00 40.83  ? 251 PRO B C   1 
ATOM   4192 O O   . PRO B 1 220 ? 124.980 100.302 149.791 1.00 46.23  ? 251 PRO B O   1 
ATOM   4193 C CB  . PRO B 1 220 ? 124.678 97.153  149.265 1.00 36.71  ? 251 PRO B CB  1 
ATOM   4194 C CG  . PRO B 1 220 ? 125.307 96.543  148.071 1.00 38.29  ? 251 PRO B CG  1 
ATOM   4195 C CD  . PRO B 1 220 ? 125.793 97.713  147.279 1.00 37.95  ? 251 PRO B CD  1 
ATOM   4196 N N   . TRP B 1 221 ? 122.945 99.658  150.511 1.00 39.88  ? 252 TRP B N   1 
ATOM   4197 C CA  . TRP B 1 221 ? 122.687 100.837 151.322 1.00 40.46  ? 252 TRP B CA  1 
ATOM   4198 C C   . TRP B 1 221 ? 121.724 100.442 152.432 1.00 44.70  ? 252 TRP B C   1 
ATOM   4199 O O   . TRP B 1 221 ? 121.113 99.374  152.399 1.00 44.52  ? 252 TRP B O   1 
ATOM   4200 C CB  . TRP B 1 221 ? 122.118 101.963 150.447 1.00 42.71  ? 252 TRP B CB  1 
ATOM   4201 C CG  . TRP B 1 221 ? 122.232 103.360 150.973 1.00 44.94  ? 252 TRP B CG  1 
ATOM   4202 C CD1 . TRP B 1 221 ? 121.313 104.039 151.715 1.00 46.43  ? 252 TRP B CD1 1 
ATOM   4203 C CD2 . TRP B 1 221 ? 123.314 104.263 150.756 1.00 46.89  ? 252 TRP B CD2 1 
ATOM   4204 N NE1 . TRP B 1 221 ? 121.764 105.302 151.992 1.00 48.22  ? 252 TRP B NE1 1 
ATOM   4205 C CE2 . TRP B 1 221 ? 122.992 105.467 151.412 1.00 49.12  ? 252 TRP B CE2 1 
ATOM   4206 C CE3 . TRP B 1 221 ? 124.532 104.169 150.077 1.00 45.65  ? 252 TRP B CE3 1 
ATOM   4207 C CZ2 . TRP B 1 221 ? 123.843 106.569 151.411 1.00 47.88  ? 252 TRP B CZ2 1 
ATOM   4208 C CZ3 . TRP B 1 221 ? 125.379 105.265 150.076 1.00 44.96  ? 252 TRP B CZ3 1 
ATOM   4209 C CH2 . TRP B 1 221 ? 125.029 106.449 150.738 1.00 44.64  ? 252 TRP B CH2 1 
ATOM   4210 N N   . GLY B 1 222 ? 121.599 101.306 153.434 1.00 51.67  ? 253 GLY B N   1 
ATOM   4211 C CA  . GLY B 1 222 ? 120.608 101.138 154.479 1.00 53.72  ? 253 GLY B CA  1 
ATOM   4212 C C   . GLY B 1 222 ? 119.259 101.691 154.074 1.00 57.51  ? 253 GLY B C   1 
ATOM   4213 O O   . GLY B 1 222 ? 119.049 102.111 152.931 1.00 58.72  ? 253 GLY B O   1 
ATOM   4214 N N   . GLU B 1 223 ? 118.326 101.703 155.023 1.00 62.62  ? 254 GLU B N   1 
ATOM   4215 C CA  . GLU B 1 223 ? 116.969 102.165 154.762 1.00 68.19  ? 254 GLU B CA  1 
ATOM   4216 C C   . GLU B 1 223 ? 116.751 103.616 155.176 1.00 63.42  ? 254 GLU B C   1 
ATOM   4217 O O   . GLU B 1 223 ? 115.651 103.970 155.611 1.00 66.23  ? 254 GLU B O   1 
ATOM   4218 C CB  . GLU B 1 223 ? 115.952 101.262 155.459 1.00 72.38  ? 254 GLU B CB  1 
ATOM   4219 C CG  . GLU B 1 223 ? 115.781 99.899  154.813 1.00 70.87  ? 254 GLU B CG  1 
ATOM   4220 C CD  . GLU B 1 223 ? 114.547 99.173  155.311 1.00 76.13  ? 254 GLU B CD  1 
ATOM   4221 O OE1 . GLU B 1 223 ? 113.879 99.692  156.230 1.00 74.51  ? 254 GLU B OE1 1 
ATOM   4222 O OE2 . GLU B 1 223 ? 114.238 98.085  154.780 1.00 84.19  ? 254 GLU B OE2 1 
ATOM   4223 N N   . LYS B 1 224 ? 117.771 104.458 155.057 1.00 57.82  ? 255 LYS B N   1 
ATOM   4224 C CA  . LYS B 1 224 ? 117.661 105.874 155.370 1.00 57.95  ? 255 LYS B CA  1 
ATOM   4225 C C   . LYS B 1 224 ? 117.877 106.682 154.102 1.00 52.53  ? 255 LYS B C   1 
ATOM   4226 O O   . LYS B 1 224 ? 118.860 106.468 153.388 1.00 54.10  ? 255 LYS B O   1 
ATOM   4227 C CB  . LYS B 1 224 ? 118.677 106.281 156.436 1.00 65.21  ? 255 LYS B CB  1 
ATOM   4228 C CG  . LYS B 1 224 ? 118.337 105.795 157.832 1.00 70.09  ? 255 LYS B CG  1 
ATOM   4229 C CD  . LYS B 1 224 ? 119.535 105.901 158.760 1.00 68.53  ? 255 LYS B CD  1 
ATOM   4230 C CE  . LYS B 1 224 ? 119.096 106.133 160.195 1.00 74.09  ? 255 LYS B CE  1 
ATOM   4231 N NZ  . LYS B 1 224 ? 120.043 105.525 161.168 1.00 71.79  ? 255 LYS B NZ  1 
ATOM   4232 N N   . ILE B 1 225 ? 116.955 107.599 153.817 1.00 50.29  ? 256 ILE B N   1 
ATOM   4233 C CA  . ILE B 1 225 ? 117.125 108.473 152.668 1.00 48.96  ? 256 ILE B CA  1 
ATOM   4234 C C   . ILE B 1 225 ? 117.988 109.654 153.092 1.00 52.22  ? 256 ILE B C   1 
ATOM   4235 O O   . ILE B 1 225 ? 117.708 110.331 154.088 1.00 59.06  ? 256 ILE B O   1 
ATOM   4236 C CB  . ILE B 1 225 ? 115.772 108.947 152.099 1.00 52.40  ? 256 ILE B CB  1 
ATOM   4237 C CG1 . ILE B 1 225 ? 114.816 107.777 151.839 1.00 53.71  ? 256 ILE B CG1 1 
ATOM   4238 C CG2 . ILE B 1 225 ? 115.973 109.661 150.778 1.00 52.29  ? 256 ILE B CG2 1 
ATOM   4239 C CD1 . ILE B 1 225 ? 113.661 107.645 152.841 1.00 53.00  ? 256 ILE B CD1 1 
ATOM   4240 N N   . ALA B 1 226 ? 119.053 109.902 152.341 1.00 49.55  ? 257 ALA B N   1 
ATOM   4241 C CA  . ALA B 1 226 ? 120.050 110.890 152.714 1.00 46.26  ? 257 ALA B CA  1 
ATOM   4242 C C   . ALA B 1 226 ? 119.973 112.098 151.793 1.00 47.55  ? 257 ALA B C   1 
ATOM   4243 O O   . ALA B 1 226 ? 119.360 112.058 150.726 1.00 50.24  ? 257 ALA B O   1 
ATOM   4244 C CB  . ALA B 1 226 ? 121.453 110.290 152.682 1.00 42.51  ? 257 ALA B CB  1 
ATOM   4245 N N   . SER B 1 227 ? 120.600 113.182 152.232 1.00 45.90  ? 258 SER B N   1 
ATOM   4246 C CA  . SER B 1 227 ? 120.595 114.435 151.493 1.00 43.58  ? 258 SER B CA  1 
ATOM   4247 C C   . SER B 1 227 ? 121.829 114.536 150.609 1.00 43.46  ? 258 SER B C   1 
ATOM   4248 O O   . SER B 1 227 ? 122.956 114.447 151.099 1.00 48.78  ? 258 SER B O   1 
ATOM   4249 C CB  . SER B 1 227 ? 120.554 115.604 152.469 1.00 47.47  ? 258 SER B CB  1 
ATOM   4250 O OG  . SER B 1 227 ? 120.781 116.823 151.799 1.00 52.65  ? 258 SER B OG  1 
ATOM   4251 N N   . VAL B 1 228 ? 121.624 114.758 149.316 1.00 43.70  ? 259 VAL B N   1 
ATOM   4252 C CA  . VAL B 1 228 ? 122.703 114.705 148.335 1.00 42.70  ? 259 VAL B CA  1 
ATOM   4253 C C   . VAL B 1 228 ? 123.066 116.124 147.924 1.00 42.71  ? 259 VAL B C   1 
ATOM   4254 O O   . VAL B 1 228 ? 122.232 116.860 147.383 1.00 47.17  ? 259 VAL B O   1 
ATOM   4255 C CB  . VAL B 1 228 ? 122.325 113.858 147.116 1.00 44.53  ? 259 VAL B CB  1 
ATOM   4256 C CG1 . VAL B 1 228 ? 123.467 113.819 146.132 1.00 43.81  ? 259 VAL B CG1 1 
ATOM   4257 C CG2 . VAL B 1 228 ? 121.992 112.468 147.548 1.00 43.95  ? 259 VAL B CG2 1 
ATOM   4258 N N   . GLU B 1 229 ? 124.315 116.502 148.172 1.00 42.46  ? 260 GLU B N   1 
ATOM   4259 C CA  . GLU B 1 229 ? 124.894 117.753 147.703 1.00 45.61  ? 260 GLU B CA  1 
ATOM   4260 C C   . GLU B 1 229 ? 126.063 117.415 146.791 1.00 46.76  ? 260 GLU B C   1 
ATOM   4261 O O   . GLU B 1 229 ? 126.967 116.682 147.191 1.00 50.45  ? 260 GLU B O   1 
ATOM   4262 C CB  . GLU B 1 229 ? 125.355 118.612 148.878 1.00 48.46  ? 260 GLU B CB  1 
ATOM   4263 C CG  . GLU B 1 229 ? 126.173 119.821 148.480 1.00 52.86  ? 260 GLU B CG  1 
ATOM   4264 C CD  . GLU B 1 229 ? 126.329 120.812 149.610 1.00 61.34  ? 260 GLU B CD  1 
ATOM   4265 O OE1 . GLU B 1 229 ? 125.889 120.507 150.738 1.00 65.73  ? 260 GLU B OE1 1 
ATOM   4266 O OE2 . GLU B 1 229 ? 126.895 121.897 149.372 1.00 64.19  ? 260 GLU B OE2 1 
ATOM   4267 N N   . ILE B 1 230 ? 126.056 117.950 145.577 1.00 46.19  ? 261 ILE B N   1 
ATOM   4268 C CA  . ILE B 1 230 ? 126.988 117.545 144.534 1.00 45.24  ? 261 ILE B CA  1 
ATOM   4269 C C   . ILE B 1 230 ? 127.937 118.694 144.233 1.00 49.09  ? 261 ILE B C   1 
ATOM   4270 O O   . ILE B 1 230 ? 127.501 119.774 143.821 1.00 56.58  ? 261 ILE B O   1 
ATOM   4271 C CB  . ILE B 1 230 ? 126.232 117.109 143.271 1.00 46.31  ? 261 ILE B CB  1 
ATOM   4272 C CG1 . ILE B 1 230 ? 125.338 115.912 143.593 1.00 48.11  ? 261 ILE B CG1 1 
ATOM   4273 C CG2 . ILE B 1 230 ? 127.196 116.815 142.142 1.00 48.51  ? 261 ILE B CG2 1 
ATOM   4274 C CD1 . ILE B 1 230 ? 124.545 115.382 142.434 1.00 53.95  ? 261 ILE B CD1 1 
ATOM   4275 N N   . ALA B 1 231 ? 129.233 118.458 144.420 1.00 49.19  ? 262 ALA B N   1 
ATOM   4276 C CA  . ALA B 1 231 ? 130.269 119.433 144.111 1.00 53.34  ? 262 ALA B CA  1 
ATOM   4277 C C   . ALA B 1 231 ? 130.922 119.055 142.791 1.00 53.95  ? 262 ALA B C   1 
ATOM   4278 O O   . ALA B 1 231 ? 131.289 117.896 142.592 1.00 56.12  ? 262 ALA B O   1 
ATOM   4279 C CB  . ALA B 1 231 ? 131.316 119.506 145.222 1.00 53.33  ? 262 ALA B CB  1 
ATOM   4280 N N   . THR B 1 232 ? 131.051 120.019 141.885 1.00 55.03  ? 263 THR B N   1 
ATOM   4281 C CA  . THR B 1 232 ? 131.557 119.755 140.545 1.00 59.42  ? 263 THR B CA  1 
ATOM   4282 C C   . THR B 1 232 ? 132.626 120.768 140.178 1.00 62.06  ? 263 THR B C   1 
ATOM   4283 O O   . THR B 1 232 ? 132.698 121.847 140.769 1.00 66.23  ? 263 THR B O   1 
ATOM   4284 C CB  . THR B 1 232 ? 130.454 119.825 139.493 1.00 64.34  ? 263 THR B CB  1 
ATOM   4285 O OG1 . THR B 1 232 ? 129.618 120.954 139.758 1.00 63.88  ? 263 THR B OG1 1 
ATOM   4286 C CG2 . THR B 1 232 ? 129.613 118.565 139.472 1.00 65.53  ? 263 THR B CG2 1 
ATOM   4287 N N   . GLU B 1 233 ? 133.455 120.417 139.194 1.00 65.10  ? 264 GLU B N   1 
ATOM   4288 C CA  . GLU B 1 233 ? 134.442 121.367 138.694 1.00 68.43  ? 264 GLU B CA  1 
ATOM   4289 C C   . GLU B 1 233 ? 133.820 122.407 137.771 1.00 67.99  ? 264 GLU B C   1 
ATOM   4290 O O   . GLU B 1 233 ? 134.238 123.567 137.793 1.00 68.66  ? 264 GLU B O   1 
ATOM   4291 C CB  . GLU B 1 233 ? 135.572 120.636 137.971 1.00 70.15  ? 264 GLU B CB  1 
ATOM   4292 C CG  . GLU B 1 233 ? 136.503 119.881 138.895 1.00 69.07  ? 264 GLU B CG  1 
ATOM   4293 C CD  . GLU B 1 233 ? 137.794 120.629 139.175 1.00 73.45  ? 264 GLU B CD  1 
ATOM   4294 O OE1 . GLU B 1 233 ? 137.796 121.876 139.097 1.00 71.57  ? 264 GLU B OE1 1 
ATOM   4295 O OE2 . GLU B 1 233 ? 138.807 119.968 139.487 1.00 75.44  ? 264 GLU B OE2 1 
ATOM   4296 N N   . THR B 1 234 ? 132.867 122.009 136.923 1.00 67.85  ? 265 THR B N   1 
ATOM   4297 C CA  . THR B 1 234 ? 132.115 122.915 136.058 1.00 72.36  ? 265 THR B CA  1 
ATOM   4298 C C   . THR B 1 234 ? 130.647 122.520 136.085 1.00 73.90  ? 265 THR B C   1 
ATOM   4299 O O   . THR B 1 234 ? 130.298 121.431 136.538 1.00 75.68  ? 265 THR B O   1 
ATOM   4300 C CB  . THR B 1 234 ? 132.596 122.897 134.592 1.00 73.54  ? 265 THR B CB  1 
ATOM   4301 O OG1 . THR B 1 234 ? 132.678 121.545 134.124 1.00 75.30  ? 265 THR B OG1 1 
ATOM   4302 C CG2 . THR B 1 234 ? 133.935 123.611 134.401 1.00 75.01  ? 265 THR B CG2 1 
ATOM   4303 N N   . LEU B 1 235 ? 129.782 123.394 135.560 1.00 72.88  ? 266 LEU B N   1 
ATOM   4304 C CA  . LEU B 1 235 ? 128.361 123.052 135.502 1.00 75.13  ? 266 LEU B CA  1 
ATOM   4305 C C   . LEU B 1 235 ? 128.011 122.133 134.342 1.00 76.53  ? 266 LEU B C   1 
ATOM   4306 O O   . LEU B 1 235 ? 126.885 121.626 134.298 1.00 79.02  ? 266 LEU B O   1 
ATOM   4307 C CB  . LEU B 1 235 ? 127.463 124.283 135.395 1.00 77.65  ? 266 LEU B CB  1 
ATOM   4308 C CG  . LEU B 1 235 ? 127.089 125.160 136.587 1.00 77.43  ? 266 LEU B CG  1 
ATOM   4309 C CD1 . LEU B 1 235 ? 128.205 126.059 137.069 1.00 75.08  ? 266 LEU B CD1 1 
ATOM   4310 C CD2 . LEU B 1 235 ? 125.857 125.949 136.226 1.00 78.17  ? 266 LEU B CD2 1 
ATOM   4311 N N   . GLU B 1 236 ? 128.926 121.921 133.394 1.00 78.27  ? 267 GLU B N   1 
ATOM   4312 C CA  . GLU B 1 236 ? 128.675 120.941 132.344 1.00 79.85  ? 267 GLU B CA  1 
ATOM   4313 C C   . GLU B 1 236 ? 128.820 119.521 132.875 1.00 76.15  ? 267 GLU B C   1 
ATOM   4314 O O   . GLU B 1 236 ? 128.216 118.587 132.340 1.00 75.52  ? 267 GLU B O   1 
ATOM   4315 C CB  . GLU B 1 236 ? 129.618 121.179 131.167 1.00 81.89  ? 267 GLU B CB  1 
ATOM   4316 C CG  . GLU B 1 236 ? 129.360 122.482 130.431 1.00 86.13  ? 267 GLU B CG  1 
ATOM   4317 C CD  . GLU B 1 236 ? 130.321 122.701 129.282 1.00 92.72  ? 267 GLU B CD  1 
ATOM   4318 O OE1 . GLU B 1 236 ? 131.266 121.898 129.135 1.00 93.31  ? 267 GLU B OE1 1 
ATOM   4319 O OE2 . GLU B 1 236 ? 130.137 123.678 128.526 1.00 94.28  ? 267 GLU B OE2 1 
ATOM   4320 N N   . MET B 1 237 ? 129.610 119.338 133.937 1.00 73.85  ? 268 MET B N   1 
ATOM   4321 C CA  . MET B 1 237 ? 129.691 118.031 134.577 1.00 71.89  ? 268 MET B CA  1 
ATOM   4322 C C   . MET B 1 237 ? 128.475 117.758 135.453 1.00 74.56  ? 268 MET B C   1 
ATOM   4323 O O   . MET B 1 237 ? 128.191 116.601 135.777 1.00 77.28  ? 268 MET B O   1 
ATOM   4324 C CB  . MET B 1 237 ? 130.979 117.911 135.389 1.00 70.48  ? 268 MET B CB  1 
ATOM   4325 C CG  . MET B 1 237 ? 132.223 117.911 134.529 1.00 74.33  ? 268 MET B CG  1 
ATOM   4326 S SD  . MET B 1 237 ? 133.755 117.843 135.464 1.00 85.04  ? 268 MET B SD  1 
ATOM   4327 C CE  . MET B 1 237 ? 133.675 116.161 136.068 1.00 70.78  ? 268 MET B CE  1 
ATOM   4328 N N   . TYR B 1 238 ? 127.762 118.805 135.877 1.00 74.12  ? 269 TYR B N   1 
ATOM   4329 C CA  . TYR B 1 238 ? 126.536 118.590 136.640 1.00 73.21  ? 269 TYR B CA  1 
ATOM   4330 C C   . TYR B 1 238 ? 125.360 118.279 135.722 1.00 73.64  ? 269 TYR B C   1 
ATOM   4331 O O   . TYR B 1 238 ? 124.455 117.524 136.093 1.00 72.75  ? 269 TYR B O   1 
ATOM   4332 C CB  . TYR B 1 238 ? 126.218 119.805 137.510 1.00 72.56  ? 269 TYR B CB  1 
ATOM   4333 C CG  . TYR B 1 238 ? 125.086 119.559 138.489 1.00 75.87  ? 269 TYR B CG  1 
ATOM   4334 C CD1 . TYR B 1 238 ? 125.293 118.796 139.640 1.00 73.99  ? 269 TYR B CD1 1 
ATOM   4335 C CD2 . TYR B 1 238 ? 123.804 120.072 138.251 1.00 74.65  ? 269 TYR B CD2 1 
ATOM   4336 C CE1 . TYR B 1 238 ? 124.251 118.559 140.538 1.00 72.52  ? 269 TYR B CE1 1 
ATOM   4337 C CE2 . TYR B 1 238 ? 122.757 119.837 139.138 1.00 72.20  ? 269 TYR B CE2 1 
ATOM   4338 C CZ  . TYR B 1 238 ? 122.995 119.080 140.277 1.00 73.14  ? 269 TYR B CZ  1 
ATOM   4339 O OH  . TYR B 1 238 ? 121.978 118.846 141.169 1.00 74.14  ? 269 TYR B OH  1 
ATOM   4340 N N   . ASN B 1 239 ? 125.337 118.887 134.533 1.00 75.67  ? 270 ASN B N   1 
ATOM   4341 C CA  . ASN B 1 239 ? 124.224 118.683 133.611 1.00 75.35  ? 270 ASN B CA  1 
ATOM   4342 C C   . ASN B 1 239 ? 124.308 117.317 132.944 1.00 75.54  ? 270 ASN B C   1 
ATOM   4343 O O   . ASN B 1 239 ? 123.283 116.708 132.619 1.00 76.80  ? 270 ASN B O   1 
ATOM   4344 C CB  . ASN B 1 239 ? 124.199 119.788 132.554 1.00 76.96  ? 270 ASN B CB  1 
ATOM   4345 C CG  . ASN B 1 239 ? 123.725 121.117 133.106 1.00 79.68  ? 270 ASN B CG  1 
ATOM   4346 O OD1 . ASN B 1 239 ? 122.537 121.310 133.357 1.00 80.80  ? 270 ASN B OD1 1 
ATOM   4347 N ND2 . ASN B 1 239 ? 124.653 122.051 133.276 1.00 79.53  ? 270 ASN B ND2 1 
ATOM   4348 N N   . GLU B 1 240 ? 125.526 116.813 132.746 1.00 75.18  ? 271 GLU B N   1 
ATOM   4349 C CA  . GLU B 1 240 ? 125.686 115.502 132.130 1.00 74.36  ? 271 GLU B CA  1 
ATOM   4350 C C   . GLU B 1 240 ? 125.557 114.384 133.154 1.00 72.39  ? 271 GLU B C   1 
ATOM   4351 O O   . GLU B 1 240 ? 125.311 113.230 132.787 1.00 75.70  ? 271 GLU B O   1 
ATOM   4352 C CB  . GLU B 1 240 ? 127.026 115.422 131.402 1.00 73.48  ? 271 GLU B CB  1 
ATOM   4353 C CG  . GLU B 1 240 ? 127.094 116.298 130.163 1.00 81.54  ? 271 GLU B CG  1 
ATOM   4354 C CD  . GLU B 1 240 ? 128.405 116.159 129.425 1.00 88.06  ? 271 GLU B CD  1 
ATOM   4355 O OE1 . GLU B 1 240 ? 129.138 115.190 129.703 1.00 79.01  ? 271 GLU B OE1 1 
ATOM   4356 O OE2 . GLU B 1 240 ? 128.705 117.018 128.569 1.00 93.13  ? 271 GLU B OE2 1 
ATOM   4357 N N   . PHE B 1 241 ? 125.722 114.696 134.442 1.00 69.68  ? 272 PHE B N   1 
ATOM   4358 C CA  . PHE B 1 241 ? 125.537 113.666 135.457 1.00 69.51  ? 272 PHE B CA  1 
ATOM   4359 C C   . PHE B 1 241 ? 124.063 113.441 135.760 1.00 74.33  ? 272 PHE B C   1 
ATOM   4360 O O   . PHE B 1 241 ? 123.620 112.292 135.858 1.00 75.00  ? 272 PHE B O   1 
ATOM   4361 C CB  . PHE B 1 241 ? 126.280 114.013 136.743 1.00 64.41  ? 272 PHE B CB  1 
ATOM   4362 C CG  . PHE B 1 241 ? 126.016 113.049 137.866 1.00 64.36  ? 272 PHE B CG  1 
ATOM   4363 C CD1 . PHE B 1 241 ? 126.298 111.685 137.719 1.00 61.06  ? 272 PHE B CD1 1 
ATOM   4364 C CD2 . PHE B 1 241 ? 125.468 113.501 139.066 1.00 65.98  ? 272 PHE B CD2 1 
ATOM   4365 C CE1 . PHE B 1 241 ? 126.032 110.793 138.749 1.00 58.35  ? 272 PHE B CE1 1 
ATOM   4366 C CE2 . PHE B 1 241 ? 125.210 112.610 140.109 1.00 65.68  ? 272 PHE B CE2 1 
ATOM   4367 C CZ  . PHE B 1 241 ? 125.497 111.257 139.945 1.00 61.96  ? 272 PHE B CZ  1 
ATOM   4368 N N   . MET B 1 242 ? 123.287 114.513 135.934 1.00 75.09  ? 273 MET B N   1 
ATOM   4369 C CA  . MET B 1 242 ? 121.899 114.315 136.335 1.00 75.39  ? 273 MET B CA  1 
ATOM   4370 C C   . MET B 1 242 ? 120.999 114.020 135.145 1.00 76.74  ? 273 MET B C   1 
ATOM   4371 O O   . MET B 1 242 ? 119.843 113.630 135.330 1.00 78.58  ? 273 MET B O   1 
ATOM   4372 C CB  . MET B 1 242 ? 121.387 115.510 137.131 1.00 73.46  ? 273 MET B CB  1 
ATOM   4373 C CG  . MET B 1 242 ? 122.327 115.926 138.237 1.00 72.75  ? 273 MET B CG  1 
ATOM   4374 S SD  . MET B 1 242 ? 121.865 115.146 139.791 1.00 82.38  ? 273 MET B SD  1 
ATOM   4375 C CE  . MET B 1 242 ? 120.380 116.033 140.200 1.00 79.33  ? 273 MET B CE  1 
ATOM   4376 N N   . GLU B 1 243 ? 121.499 114.211 133.923 1.00 75.33  ? 274 GLU B N   1 
ATOM   4377 C CA  . GLU B 1 243 ? 120.895 113.545 132.777 1.00 76.56  ? 274 GLU B CA  1 
ATOM   4378 C C   . GLU B 1 243 ? 121.104 112.041 132.860 1.00 76.54  ? 274 GLU B C   1 
ATOM   4379 O O   . GLU B 1 243 ? 120.201 111.262 132.535 1.00 78.93  ? 274 GLU B O   1 
ATOM   4380 C CB  . GLU B 1 243 ? 121.479 114.087 131.477 1.00 77.67  ? 274 GLU B CB  1 
ATOM   4381 C CG  . GLU B 1 243 ? 120.665 113.732 130.247 1.00 81.71  ? 274 GLU B CG  1 
ATOM   4382 C CD  . GLU B 1 243 ? 121.454 113.887 128.963 1.00 84.66  ? 274 GLU B CD  1 
ATOM   4383 O OE1 . GLU B 1 243 ? 122.659 114.209 129.038 1.00 83.30  ? 274 GLU B OE1 1 
ATOM   4384 O OE2 . GLU B 1 243 ? 120.868 113.685 127.878 1.00 87.16  ? 274 GLU B OE2 1 
ATOM   4385 N N   . ALA B 1 244 ? 122.292 111.614 133.297 1.00 72.70  ? 275 ALA B N   1 
ATOM   4386 C CA  . ALA B 1 244 ? 122.574 110.188 133.421 1.00 72.43  ? 275 ALA B CA  1 
ATOM   4387 C C   . ALA B 1 244 ? 121.945 109.607 134.679 1.00 72.03  ? 275 ALA B C   1 
ATOM   4388 O O   . ALA B 1 244 ? 121.718 108.395 134.764 1.00 74.78  ? 275 ALA B O   1 
ATOM   4389 C CB  . ALA B 1 244 ? 124.081 109.953 133.419 1.00 64.98  ? 275 ALA B CB  1 
ATOM   4390 N N   . ALA B 1 245 ? 121.673 110.451 135.676 1.00 72.09  ? 276 ALA B N   1 
ATOM   4391 C CA  . ALA B 1 245 ? 120.959 109.986 136.860 1.00 72.67  ? 276 ALA B CA  1 
ATOM   4392 C C   . ALA B 1 245 ? 119.471 109.840 136.580 1.00 73.07  ? 276 ALA B C   1 
ATOM   4393 O O   . ALA B 1 245 ? 118.791 109.024 137.213 1.00 75.49  ? 276 ALA B O   1 
ATOM   4394 C CB  . ALA B 1 245 ? 121.192 110.940 138.029 1.00 74.99  ? 276 ALA B CB  1 
ATOM   4395 N N   . ARG B 1 246 ? 118.946 110.632 135.640 1.00 73.46  ? 277 ARG B N   1 
ATOM   4396 C CA  . ARG B 1 246 ? 117.531 110.556 135.290 1.00 74.30  ? 277 ARG B CA  1 
ATOM   4397 C C   . ARG B 1 246 ? 117.238 109.310 134.467 1.00 76.24  ? 277 ARG B C   1 
ATOM   4398 O O   . ARG B 1 246 ? 116.132 108.763 134.528 1.00 77.95  ? 277 ARG B O   1 
ATOM   4399 C CB  . ARG B 1 246 ? 117.121 111.816 134.524 1.00 75.54  ? 277 ARG B CB  1 
ATOM   4400 C CG  . ARG B 1 246 ? 115.632 112.162 134.517 1.00 77.56  ? 277 ARG B CG  1 
ATOM   4401 C CD  . ARG B 1 246 ? 114.928 111.731 133.222 1.00 81.48  ? 277 ARG B CD  1 
ATOM   4402 N NE  . ARG B 1 246 ? 115.767 111.906 132.040 1.00 83.34  ? 277 ARG B NE  1 
ATOM   4403 C CZ  . ARG B 1 246 ? 115.899 113.036 131.360 1.00 88.40  ? 277 ARG B CZ  1 
ATOM   4404 N NH1 . ARG B 1 246 ? 115.250 114.135 131.708 1.00 93.98  ? 277 ARG B NH1 1 
ATOM   4405 N NH2 . ARG B 1 246 ? 116.704 113.065 130.302 1.00 87.59  ? 277 ARG B NH2 1 
ATOM   4406 N N   . GLN B 1 247 ? 118.224 108.841 133.698 1.00 76.96  ? 278 GLN B N   1 
ATOM   4407 C CA  . GLN B 1 247 ? 118.031 107.655 132.871 1.00 76.01  ? 278 GLN B CA  1 
ATOM   4408 C C   . GLN B 1 247 ? 118.099 106.378 133.697 1.00 74.79  ? 278 GLN B C   1 
ATOM   4409 O O   . GLN B 1 247 ? 117.612 105.330 133.259 1.00 78.12  ? 278 GLN B O   1 
ATOM   4410 C CB  . GLN B 1 247 ? 119.075 107.628 131.758 1.00 76.32  ? 278 GLN B CB  1 
ATOM   4411 C CG  . GLN B 1 247 ? 118.890 108.729 130.735 1.00 80.97  ? 278 GLN B CG  1 
ATOM   4412 C CD  . GLN B 1 247 ? 119.985 108.746 129.695 1.00 87.93  ? 278 GLN B CD  1 
ATOM   4413 O OE1 . GLN B 1 247 ? 120.793 107.822 129.613 1.00 91.64  ? 278 GLN B OE1 1 
ATOM   4414 N NE2 . GLN B 1 247 ? 120.029 109.807 128.900 1.00 88.47  ? 278 GLN B NE2 1 
ATOM   4415 N N   . GLU B 1 248 ? 118.701 106.443 134.880 1.00 71.85  ? 279 GLU B N   1 
ATOM   4416 C CA  . GLU B 1 248 ? 118.710 105.335 135.820 1.00 70.29  ? 279 GLU B CA  1 
ATOM   4417 C C   . GLU B 1 248 ? 117.636 105.464 136.887 1.00 74.01  ? 279 GLU B C   1 
ATOM   4418 O O   . GLU B 1 248 ? 117.691 104.729 137.878 1.00 73.60  ? 279 GLU B O   1 
ATOM   4419 C CB  . GLU B 1 248 ? 120.083 105.214 136.481 1.00 64.50  ? 279 GLU B CB  1 
ATOM   4420 C CG  . GLU B 1 248 ? 121.107 104.532 135.608 1.00 61.50  ? 279 GLU B CG  1 
ATOM   4421 C CD  . GLU B 1 248 ? 120.847 103.048 135.474 1.00 63.44  ? 279 GLU B CD  1 
ATOM   4422 O OE1 . GLU B 1 248 ? 120.374 102.433 136.453 1.00 63.00  ? 279 GLU B OE1 1 
ATOM   4423 O OE2 . GLU B 1 248 ? 121.109 102.496 134.385 1.00 64.39  ? 279 GLU B OE2 1 
ATOM   4424 N N   . HIS B 1 249 ? 116.684 106.383 136.703 1.00 74.12  ? 280 HIS B N   1 
ATOM   4425 C CA  . HIS B 1 249 ? 115.513 106.695 137.531 1.00 74.81  ? 280 HIS B CA  1 
ATOM   4426 C C   . HIS B 1 249 ? 115.876 107.085 138.959 1.00 74.80  ? 280 HIS B C   1 
ATOM   4427 O O   . HIS B 1 249 ? 115.121 106.759 139.880 1.00 77.69  ? 280 HIS B O   1 
ATOM   4428 C CB  . HIS B 1 249 ? 114.483 105.554 137.573 1.00 79.01  ? 280 HIS B CB  1 
ATOM   4429 C CG  . HIS B 1 249 ? 113.772 105.340 136.275 1.00 82.91  ? 280 HIS B CG  1 
ATOM   4430 N ND1 . HIS B 1 249 ? 113.569 106.355 135.365 1.00 86.09  ? 280 HIS B ND1 1 
ATOM   4431 C CD2 . HIS B 1 249 ? 113.230 104.228 135.726 1.00 84.60  ? 280 HIS B CD2 1 
ATOM   4432 C CE1 . HIS B 1 249 ? 112.924 105.878 134.316 1.00 87.91  ? 280 HIS B CE1 1 
ATOM   4433 N NE2 . HIS B 1 249 ? 112.708 104.590 134.509 1.00 89.66  ? 280 HIS B NE2 1 
ATOM   4434 N N   . MET B 1 250 ? 117.001 107.755 139.179 1.00 72.85  ? 281 MET B N   1 
ATOM   4435 C CA  . MET B 1 250 ? 117.340 108.304 140.482 1.00 71.67  ? 281 MET B CA  1 
ATOM   4436 C C   . MET B 1 250 ? 117.224 109.819 140.435 1.00 71.05  ? 281 MET B C   1 
ATOM   4437 O O   . MET B 1 250 ? 117.919 110.478 139.657 1.00 69.41  ? 281 MET B O   1 
ATOM   4438 C CB  . MET B 1 250 ? 118.753 107.908 140.911 1.00 70.84  ? 281 MET B CB  1 
ATOM   4439 C CG  . MET B 1 250 ? 118.994 106.415 141.008 1.00 70.42  ? 281 MET B CG  1 
ATOM   4440 S SD  . MET B 1 250 ? 120.742 105.985 141.106 1.00 71.37  ? 281 MET B SD  1 
ATOM   4441 C CE  . MET B 1 250 ? 121.462 107.079 139.886 1.00 64.52  ? 281 MET B CE  1 
ATOM   4442 N N   . CYS B 1 251 ? 116.342 110.363 141.261 1.00 70.59  ? 282 CYS B N   1 
ATOM   4443 C CA  . CYS B 1 251 ? 116.294 111.791 141.526 1.00 65.53  ? 282 CYS B CA  1 
ATOM   4444 C C   . CYS B 1 251 ? 116.834 112.055 142.925 1.00 62.67  ? 282 CYS B C   1 
ATOM   4445 O O   . CYS B 1 251 ? 116.287 111.572 143.922 1.00 63.98  ? 282 CYS B O   1 
ATOM   4446 C CB  . CYS B 1 251 ? 114.879 112.343 141.289 1.00 63.62  ? 282 CYS B CB  1 
ATOM   4447 S SG  . CYS B 1 251 ? 113.474 111.665 142.223 1.00 75.69  ? 282 CYS B SG  1 
ATOM   4448 N N   . LEU B 1 252 ? 117.955 112.769 142.979 1.00 59.19  ? 283 LEU B N   1 
ATOM   4449 C CA  . LEU B 1 252 ? 118.702 113.011 144.206 1.00 56.70  ? 283 LEU B CA  1 
ATOM   4450 C C   . LEU B 1 252 ? 118.282 114.364 144.757 1.00 59.27  ? 283 LEU B C   1 
ATOM   4451 O O   . LEU B 1 252 ? 118.549 115.401 144.142 1.00 62.46  ? 283 LEU B O   1 
ATOM   4452 C CB  . LEU B 1 252 ? 120.203 112.967 143.939 1.00 60.45  ? 283 LEU B CB  1 
ATOM   4453 C CG  . LEU B 1 252 ? 120.731 111.713 143.244 1.00 62.22  ? 283 LEU B CG  1 
ATOM   4454 C CD1 . LEU B 1 252 ? 122.139 111.938 142.728 1.00 59.66  ? 283 LEU B CD1 1 
ATOM   4455 C CD2 . LEU B 1 252 ? 120.696 110.529 144.188 1.00 61.76  ? 283 LEU B CD2 1 
ATOM   4456 N N   . MET B 1 253 ? 117.643 114.350 145.921 1.00 59.37  ? 284 MET B N   1 
ATOM   4457 C CA  . MET B 1 253 ? 117.105 115.545 146.545 1.00 59.32  ? 284 MET B CA  1 
ATOM   4458 C C   . MET B 1 253 ? 117.933 115.893 147.769 1.00 54.34  ? 284 MET B C   1 
ATOM   4459 O O   . MET B 1 253 ? 118.494 115.019 148.431 1.00 55.62  ? 284 MET B O   1 
ATOM   4460 C CB  . MET B 1 253 ? 115.641 115.351 146.961 1.00 58.53  ? 284 MET B CB  1 
ATOM   4461 C CG  . MET B 1 253 ? 114.743 114.770 145.892 1.00 57.81  ? 284 MET B CG  1 
ATOM   4462 S SD  . MET B 1 253 ? 114.119 116.067 144.826 1.00 58.72  ? 284 MET B SD  1 
ATOM   4463 C CE  . MET B 1 253 ? 112.965 116.836 145.947 1.00 65.52  ? 284 MET B CE  1 
ATOM   4464 N N   . HIS B 1 254 ? 117.997 117.184 148.071 1.00 49.44  ? 285 HIS B N   1 
ATOM   4465 C CA  . HIS B 1 254 ? 118.647 117.670 149.278 1.00 51.09  ? 285 HIS B CA  1 
ATOM   4466 C C   . HIS B 1 254 ? 117.587 118.014 150.313 1.00 53.39  ? 285 HIS B C   1 
ATOM   4467 O O   . HIS B 1 254 ? 116.602 118.687 149.998 1.00 59.04  ? 285 HIS B O   1 
ATOM   4468 C CB  . HIS B 1 254 ? 119.522 118.887 148.976 1.00 52.04  ? 285 HIS B CB  1 
ATOM   4469 C CG  . HIS B 1 254 ? 120.056 119.574 150.194 1.00 53.41  ? 285 HIS B CG  1 
ATOM   4470 N ND1 . HIS B 1 254 ? 121.189 119.149 150.852 1.00 54.37  ? 285 HIS B ND1 1 
ATOM   4471 C CD2 . HIS B 1 254 ? 119.635 120.682 150.850 1.00 55.14  ? 285 HIS B CD2 1 
ATOM   4472 C CE1 . HIS B 1 254 ? 121.427 119.947 151.877 1.00 57.51  ? 285 HIS B CE1 1 
ATOM   4473 N NE2 . HIS B 1 254 ? 120.499 120.886 151.898 1.00 57.96  ? 285 HIS B NE2 1 
ATOM   4474 N N   . PHE B 1 255 ? 117.787 117.549 151.542 1.00 51.71  ? 286 PHE B N   1 
ATOM   4475 C CA  . PHE B 1 255 ? 116.897 117.859 152.648 1.00 52.69  ? 286 PHE B CA  1 
ATOM   4476 C C   . PHE B 1 255 ? 117.674 118.610 153.715 1.00 59.23  ? 286 PHE B C   1 
ATOM   4477 O O   . PHE B 1 255 ? 118.857 118.916 153.555 1.00 61.86  ? 286 PHE B O   1 
ATOM   4478 C CB  . PHE B 1 255 ? 116.293 116.608 153.297 1.00 52.99  ? 286 PHE B CB  1 
ATOM   4479 C CG  . PHE B 1 255 ? 115.883 115.549 152.329 1.00 55.94  ? 286 PHE B CG  1 
ATOM   4480 C CD1 . PHE B 1 255 ? 114.935 115.814 151.340 1.00 57.20  ? 286 PHE B CD1 1 
ATOM   4481 C CD2 . PHE B 1 255 ? 116.433 114.272 152.425 1.00 56.40  ? 286 PHE B CD2 1 
ATOM   4482 C CE1 . PHE B 1 255 ? 114.549 114.815 150.444 1.00 57.73  ? 286 PHE B CE1 1 
ATOM   4483 C CE2 . PHE B 1 255 ? 116.062 113.270 151.540 1.00 56.12  ? 286 PHE B CE2 1 
ATOM   4484 C CZ  . PHE B 1 255 ? 115.118 113.542 150.549 1.00 60.03  ? 286 PHE B CZ  1 
ATOM   4485 N N   . LYS B 1 256 ? 116.983 118.910 154.814 1.00 64.23  ? 287 LYS B N   1 
ATOM   4486 C CA  . LYS B 1 256 ? 117.640 119.289 156.062 1.00 65.28  ? 287 LYS B CA  1 
ATOM   4487 C C   . LYS B 1 256 ? 117.668 118.051 156.953 1.00 65.19  ? 287 LYS B C   1 
ATOM   4488 O O   . LYS B 1 256 ? 117.031 117.978 158.007 1.00 66.44  ? 287 LYS B O   1 
ATOM   4489 C CB  . LYS B 1 256 ? 116.929 120.460 156.727 1.00 67.82  ? 287 LYS B CB  1 
ATOM   4490 C CG  . LYS B 1 256 ? 117.833 121.280 157.638 1.00 74.12  ? 287 LYS B CG  1 
ATOM   4491 C CD  . LYS B 1 256 ? 117.202 122.607 158.019 1.00 78.87  ? 287 LYS B CD  1 
ATOM   4492 C CE  . LYS B 1 256 ? 118.140 123.427 158.891 1.00 78.27  ? 287 LYS B CE  1 
ATOM   4493 N NZ  . LYS B 1 256 ? 117.555 124.747 159.258 1.00 76.33  ? 287 LYS B NZ  1 
ATOM   4494 N N   . SER B 1 257 ? 118.426 117.054 156.505 1.00 63.81  ? 288 SER B N   1 
ATOM   4495 C CA  . SER B 1 257 ? 118.525 115.760 157.164 1.00 61.94  ? 288 SER B CA  1 
ATOM   4496 C C   . SER B 1 257 ? 119.892 115.626 157.815 1.00 63.21  ? 288 SER B C   1 
ATOM   4497 O O   . SER B 1 257 ? 120.846 116.301 157.417 1.00 66.42  ? 288 SER B O   1 
ATOM   4498 C CB  . SER B 1 257 ? 118.306 114.619 156.170 1.00 60.11  ? 288 SER B CB  1 
ATOM   4499 O OG  . SER B 1 257 ? 118.841 113.408 156.666 1.00 60.61  ? 288 SER B OG  1 
ATOM   4500 N N   . ASP B 1 258 ? 119.979 114.761 158.827 1.00 64.42  ? 289 ASP B N   1 
ATOM   4501 C CA  . ASP B 1 258 ? 121.242 114.587 159.536 1.00 67.76  ? 289 ASP B CA  1 
ATOM   4502 C C   . ASP B 1 258 ? 122.211 113.724 158.735 1.00 66.66  ? 289 ASP B C   1 
ATOM   4503 O O   . ASP B 1 258 ? 123.432 113.858 158.872 1.00 68.67  ? 289 ASP B O   1 
ATOM   4504 C CB  . ASP B 1 258 ? 120.990 113.985 160.918 1.00 67.33  ? 289 ASP B CB  1 
ATOM   4505 C CG  . ASP B 1 258 ? 122.035 114.405 161.936 1.00 67.27  ? 289 ASP B CG  1 
ATOM   4506 O OD1 . ASP B 1 258 ? 122.951 115.172 161.573 1.00 63.86  ? 289 ASP B OD1 1 
ATOM   4507 O OD2 . ASP B 1 258 ? 121.934 113.973 163.103 1.00 69.50  ? 289 ASP B OD2 1 
ATOM   4508 N N   . ASP B 1 259 ? 121.687 112.830 157.901 1.00 61.46  ? 290 ASP B N   1 
ATOM   4509 C CA  . ASP B 1 259 ? 122.511 112.046 156.988 1.00 56.38  ? 290 ASP B CA  1 
ATOM   4510 C C   . ASP B 1 259 ? 122.802 112.892 155.755 1.00 53.75  ? 290 ASP B C   1 
ATOM   4511 O O   . ASP B 1 259 ? 121.908 113.564 155.236 1.00 58.50  ? 290 ASP B O   1 
ATOM   4512 C CB  . ASP B 1 259 ? 121.800 110.753 156.605 1.00 61.67  ? 290 ASP B CB  1 
ATOM   4513 C CG  . ASP B 1 259 ? 121.382 109.938 157.810 1.00 68.27  ? 290 ASP B CG  1 
ATOM   4514 O OD1 . ASP B 1 259 ? 121.899 110.203 158.917 1.00 70.85  ? 290 ASP B OD1 1 
ATOM   4515 O OD2 . ASP B 1 259 ? 120.530 109.038 157.652 1.00 63.80  ? 290 ASP B OD2 1 
ATOM   4516 N N   . ASN B 1 260 ? 124.043 112.864 155.282 1.00 48.62  ? 291 ASN B N   1 
ATOM   4517 C CA  . ASN B 1 260 ? 124.442 113.630 154.110 1.00 47.53  ? 291 ASN B CA  1 
ATOM   4518 C C   . ASN B 1 260 ? 125.179 112.719 153.143 1.00 43.35  ? 291 ASN B C   1 
ATOM   4519 O O   . ASN B 1 260 ? 125.732 111.696 153.552 1.00 47.44  ? 291 ASN B O   1 
ATOM   4520 C CB  . ASN B 1 260 ? 125.325 114.816 154.496 1.00 53.26  ? 291 ASN B CB  1 
ATOM   4521 C CG  . ASN B 1 260 ? 124.559 115.903 155.212 1.00 57.95  ? 291 ASN B CG  1 
ATOM   4522 O OD1 . ASN B 1 260 ? 123.444 116.247 154.829 1.00 59.08  ? 291 ASN B OD1 1 
ATOM   4523 N ND2 . ASN B 1 260 ? 125.154 116.451 156.262 1.00 57.67  ? 291 ASN B ND2 1 
ATOM   4524 N N   . VAL B 1 261 ? 125.143 113.069 151.860 1.00 39.89  ? 292 VAL B N   1 
ATOM   4525 C CA  . VAL B 1 261 ? 125.871 112.380 150.800 1.00 38.10  ? 292 VAL B CA  1 
ATOM   4526 C C   . VAL B 1 261 ? 126.536 113.454 149.946 1.00 41.09  ? 292 VAL B C   1 
ATOM   4527 O O   . VAL B 1 261 ? 125.871 114.398 149.507 1.00 46.25  ? 292 VAL B O   1 
ATOM   4528 C CB  . VAL B 1 261 ? 124.930 111.475 149.976 1.00 38.31  ? 292 VAL B CB  1 
ATOM   4529 C CG1 . VAL B 1 261 ? 125.475 111.158 148.597 1.00 39.39  ? 292 VAL B CG1 1 
ATOM   4530 C CG2 . VAL B 1 261 ? 124.688 110.160 150.689 1.00 40.17  ? 292 VAL B CG2 1 
ATOM   4531 N N   . TYR B 1 262 ? 127.850 113.343 149.741 1.00 38.27  ? 293 TYR B N   1 
ATOM   4532 C CA  . TYR B 1 262 ? 128.595 114.326 148.961 1.00 37.65  ? 293 TYR B CA  1 
ATOM   4533 C C   . TYR B 1 262 ? 129.232 113.650 147.756 1.00 39.40  ? 293 TYR B C   1 
ATOM   4534 O O   . TYR B 1 262 ? 130.301 113.050 147.877 1.00 45.06  ? 293 TYR B O   1 
ATOM   4535 C CB  . TYR B 1 262 ? 129.665 115.006 149.806 1.00 41.61  ? 293 TYR B CB  1 
ATOM   4536 C CG  . TYR B 1 262 ? 129.150 115.719 151.028 1.00 50.42  ? 293 TYR B CG  1 
ATOM   4537 C CD1 . TYR B 1 262 ? 128.650 117.023 150.937 1.00 54.00  ? 293 TYR B CD1 1 
ATOM   4538 C CD2 . TYR B 1 262 ? 129.190 115.101 152.281 1.00 53.45  ? 293 TYR B CD2 1 
ATOM   4539 C CE1 . TYR B 1 262 ? 128.184 117.691 152.067 1.00 56.72  ? 293 TYR B CE1 1 
ATOM   4540 C CE2 . TYR B 1 262 ? 128.727 115.756 153.416 1.00 56.56  ? 293 TYR B CE2 1 
ATOM   4541 C CZ  . TYR B 1 262 ? 128.230 117.047 153.297 1.00 60.17  ? 293 TYR B CZ  1 
ATOM   4542 O OH  . TYR B 1 262 ? 127.774 117.697 154.419 1.00 62.65  ? 293 TYR B OH  1 
ATOM   4543 N N   . ILE B 1 263 ? 128.611 113.776 146.591 1.00 35.84  ? 294 ILE B N   1 
ATOM   4544 C CA  . ILE B 1 263 ? 129.150 113.215 145.358 1.00 35.67  ? 294 ILE B CA  1 
ATOM   4545 C C   . ILE B 1 263 ? 130.005 114.287 144.702 1.00 41.74  ? 294 ILE B C   1 
ATOM   4546 O O   . ILE B 1 263 ? 129.480 115.236 144.115 1.00 48.96  ? 294 ILE B O   1 
ATOM   4547 C CB  . ILE B 1 263 ? 128.038 112.740 144.419 1.00 39.85  ? 294 ILE B CB  1 
ATOM   4548 C CG1 . ILE B 1 263 ? 127.007 111.929 145.205 1.00 42.99  ? 294 ILE B CG1 1 
ATOM   4549 C CG2 . ILE B 1 263 ? 128.634 111.930 143.287 1.00 43.52  ? 294 ILE B CG2 1 
ATOM   4550 C CD1 . ILE B 1 263 ? 125.877 111.359 144.373 1.00 48.32  ? 294 ILE B CD1 1 
ATOM   4551 N N   . MET B 1 264 ? 131.323 114.136 144.778 1.00 42.16  ? 295 MET B N   1 
ATOM   4552 C CA  . MET B 1 264 ? 132.258 115.147 144.304 1.00 43.27  ? 295 MET B CA  1 
ATOM   4553 C C   . MET B 1 264 ? 132.863 114.722 142.977 1.00 45.73  ? 295 MET B C   1 
ATOM   4554 O O   . MET B 1 264 ? 133.252 113.562 142.810 1.00 48.99  ? 295 MET B O   1 
ATOM   4555 C CB  . MET B 1 264 ? 133.356 115.396 145.332 1.00 43.81  ? 295 MET B CB  1 
ATOM   4556 C CG  . MET B 1 264 ? 132.835 116.040 146.588 1.00 49.02  ? 295 MET B CG  1 
ATOM   4557 S SD  . MET B 1 264 ? 134.098 116.342 147.824 1.00 78.82  ? 295 MET B SD  1 
ATOM   4558 C CE  . MET B 1 264 ? 133.086 116.998 149.141 1.00 68.21  ? 295 MET B CE  1 
ATOM   4559 N N   . PHE B 1 265 ? 132.945 115.664 142.042 1.00 47.51  ? 296 PHE B N   1 
ATOM   4560 C CA  . PHE B 1 265 ? 133.436 115.420 140.691 1.00 49.70  ? 296 PHE B CA  1 
ATOM   4561 C C   . PHE B 1 265 ? 134.700 116.235 140.466 1.00 55.43  ? 296 PHE B C   1 
ATOM   4562 O O   . PHE B 1 265 ? 134.628 117.451 140.276 1.00 62.79  ? 296 PHE B O   1 
ATOM   4563 C CB  . PHE B 1 265 ? 132.378 115.786 139.649 1.00 50.18  ? 296 PHE B CB  1 
ATOM   4564 C CG  . PHE B 1 265 ? 131.220 114.837 139.608 1.00 50.98  ? 296 PHE B CG  1 
ATOM   4565 C CD1 . PHE B 1 265 ? 130.099 115.046 140.409 1.00 51.75  ? 296 PHE B CD1 1 
ATOM   4566 C CD2 . PHE B 1 265 ? 131.252 113.732 138.761 1.00 53.34  ? 296 PHE B CD2 1 
ATOM   4567 C CE1 . PHE B 1 265 ? 129.029 114.159 140.372 1.00 53.10  ? 296 PHE B CE1 1 
ATOM   4568 C CE2 . PHE B 1 265 ? 130.190 112.833 138.724 1.00 53.44  ? 296 PHE B CE2 1 
ATOM   4569 C CZ  . PHE B 1 265 ? 129.082 113.053 139.529 1.00 54.77  ? 296 PHE B CZ  1 
ATOM   4570 N N   . GLY B 1 266 ? 135.850 115.568 140.480 1.00 53.48  ? 297 GLY B N   1 
ATOM   4571 C CA  . GLY B 1 266 ? 137.106 116.255 140.260 1.00 56.12  ? 297 GLY B CA  1 
ATOM   4572 C C   . GLY B 1 266 ? 138.242 115.737 141.114 1.00 60.66  ? 297 GLY B C   1 
ATOM   4573 O O   . GLY B 1 266 ? 138.012 115.112 142.153 1.00 60.79  ? 297 GLY B O   1 
ATOM   4574 N N   . ASN B 1 267 ? 139.478 115.984 140.674 1.00 67.02  ? 298 ASN B N   1 
ATOM   4575 C CA  . ASN B 1 267 ? 140.647 115.532 141.422 1.00 68.62  ? 298 ASN B CA  1 
ATOM   4576 C C   . ASN B 1 267 ? 140.931 116.428 142.621 1.00 71.51  ? 298 ASN B C   1 
ATOM   4577 O O   . ASN B 1 267 ? 141.303 115.945 143.696 1.00 72.91  ? 298 ASN B O   1 
ATOM   4578 C CB  . ASN B 1 267 ? 141.863 115.485 140.502 1.00 70.27  ? 298 ASN B CB  1 
ATOM   4579 C CG  . ASN B 1 267 ? 141.981 114.180 139.765 1.00 70.11  ? 298 ASN B CG  1 
ATOM   4580 O OD1 . ASN B 1 267 ? 141.968 113.113 140.370 1.00 71.14  ? 298 ASN B OD1 1 
ATOM   4581 N ND2 . ASN B 1 267 ? 142.086 114.254 138.447 1.00 67.13  ? 298 ASN B ND2 1 
ATOM   4582 N N   . LYS B 1 268 ? 140.766 117.740 142.455 1.00 70.13  ? 299 LYS B N   1 
ATOM   4583 C CA  . LYS B 1 268 ? 141.241 118.675 143.469 1.00 71.16  ? 299 LYS B CA  1 
ATOM   4584 C C   . LYS B 1 268 ? 140.188 118.934 144.539 1.00 76.06  ? 299 LYS B C   1 
ATOM   4585 O O   . LYS B 1 268 ? 140.472 119.597 145.543 1.00 79.30  ? 299 LYS B O   1 
ATOM   4586 C CB  . LYS B 1 268 ? 141.665 119.986 142.809 1.00 71.88  ? 299 LYS B CB  1 
ATOM   4587 C CG  . LYS B 1 268 ? 143.158 120.100 142.515 1.00 77.91  ? 299 LYS B CG  1 
ATOM   4588 C CD  . LYS B 1 268 ? 143.557 119.360 141.244 1.00 83.24  ? 299 LYS B CD  1 
ATOM   4589 C CE  . LYS B 1 268 ? 142.952 120.004 140.007 1.00 83.21  ? 299 LYS B CE  1 
ATOM   4590 N NZ  . LYS B 1 268 ? 143.369 119.312 138.755 1.00 82.75  ? 299 LYS B NZ  1 
ATOM   4591 N N   . LEU B 1 269 ? 138.971 118.422 144.347 1.00 73.44  ? 300 LEU B N   1 
ATOM   4592 C CA  . LEU B 1 269 ? 137.841 118.812 145.184 1.00 66.11  ? 300 LEU B CA  1 
ATOM   4593 C C   . LEU B 1 269 ? 137.827 118.077 146.515 1.00 72.66  ? 300 LEU B C   1 
ATOM   4594 O O   . LEU B 1 269 ? 137.656 118.687 147.576 1.00 76.42  ? 300 LEU B O   1 
ATOM   4595 C CB  . LEU B 1 269 ? 136.528 118.573 144.434 1.00 61.27  ? 300 LEU B CB  1 
ATOM   4596 C CG  . LEU B 1 269 ? 135.858 119.751 143.732 1.00 63.32  ? 300 LEU B CG  1 
ATOM   4597 C CD1 . LEU B 1 269 ? 136.714 120.361 142.641 1.00 65.29  ? 300 LEU B CD1 1 
ATOM   4598 C CD2 . LEU B 1 269 ? 134.539 119.297 143.161 1.00 59.59  ? 300 LEU B CD2 1 
ATOM   4599 N N   . ALA B 1 270 ? 138.003 116.758 146.475 1.00 73.84  ? 301 ALA B N   1 
ATOM   4600 C CA  . ALA B 1 270 ? 137.989 115.942 147.687 1.00 75.06  ? 301 ALA B CA  1 
ATOM   4601 C C   . ALA B 1 270 ? 139.410 115.846 148.240 1.00 80.73  ? 301 ALA B C   1 
ATOM   4602 O O   . ALA B 1 270 ? 140.114 114.847 148.093 1.00 83.27  ? 301 ALA B O   1 
ATOM   4603 C CB  . ALA B 1 270 ? 137.401 114.570 147.401 1.00 63.72  ? 301 ALA B CB  1 
ATOM   4604 N N   . SER B 1 271 ? 139.835 116.930 148.879 1.00 81.76  ? 302 SER B N   1 
ATOM   4605 C CA  . SER B 1 271 ? 141.159 117.017 149.478 1.00 83.91  ? 302 SER B CA  1 
ATOM   4606 C C   . SER B 1 271 ? 141.009 117.449 150.927 1.00 91.54  ? 302 SER B C   1 
ATOM   4607 O O   . SER B 1 271 ? 140.871 118.650 151.197 1.00 91.87  ? 302 SER B O   1 
ATOM   4608 C CB  . SER B 1 271 ? 142.045 117.996 148.707 1.00 84.68  ? 302 SER B CB  1 
ATOM   4609 O OG  . SER B 1 271 ? 143.353 118.030 149.247 1.00 90.58  ? 302 SER B OG  1 
ATOM   4610 N N   . HIS B 1 272 ? 141.047 116.454 151.836 1.00 91.87  ? 303 HIS B N   1 
ATOM   4611 C CA  . HIS B 1 272 ? 140.878 116.575 153.300 1.00 94.05  ? 303 HIS B CA  1 
ATOM   4612 C C   . HIS B 1 272 ? 139.558 117.248 153.680 1.00 94.58  ? 303 HIS B C   1 
ATOM   4613 O O   . HIS B 1 272 ? 139.530 118.275 154.361 1.00 97.62  ? 303 HIS B O   1 
ATOM   4614 C CB  . HIS B 1 272 ? 142.072 117.283 153.958 1.00 92.15  ? 303 HIS B CB  1 
ATOM   4615 N N   . PHE B 1 273 ? 138.452 116.663 153.225 1.00 90.20  ? 304 PHE B N   1 
ATOM   4616 C CA  . PHE B 1 273 ? 137.142 117.240 153.495 1.00 90.37  ? 304 PHE B CA  1 
ATOM   4617 C C   . PHE B 1 273 ? 136.678 116.854 154.895 1.00 92.43  ? 304 PHE B C   1 
ATOM   4618 O O   . PHE B 1 273 ? 137.023 115.782 155.401 1.00 92.56  ? 304 PHE B O   1 
ATOM   4619 C CB  . PHE B 1 273 ? 136.138 116.778 152.444 1.00 88.39  ? 304 PHE B CB  1 
ATOM   4620 C CG  . PHE B 1 273 ? 135.014 117.738 152.231 1.00 90.29  ? 304 PHE B CG  1 
ATOM   4621 C CD1 . PHE B 1 273 ? 135.228 118.919 151.516 1.00 88.69  ? 304 PHE B CD1 1 
ATOM   4622 C CD2 . PHE B 1 273 ? 133.747 117.474 152.752 1.00 89.40  ? 304 PHE B CD2 1 
ATOM   4623 C CE1 . PHE B 1 273 ? 134.186 119.827 151.313 1.00 89.18  ? 304 PHE B CE1 1 
ATOM   4624 C CE2 . PHE B 1 273 ? 132.696 118.372 152.556 1.00 85.40  ? 304 PHE B CE2 1 
ATOM   4625 C CZ  . PHE B 1 273 ? 132.919 119.550 151.837 1.00 89.63  ? 304 PHE B CZ  1 
ATOM   4626 N N   . LYS B 1 274 ? 135.891 117.727 155.522 1.00 92.55  ? 305 LYS B N   1 
ATOM   4627 C CA  . LYS B 1 274 ? 135.663 117.643 156.959 1.00 91.55  ? 305 LYS B CA  1 
ATOM   4628 C C   . LYS B 1 274 ? 134.224 117.328 157.355 1.00 88.80  ? 305 LYS B C   1 
ATOM   4629 O O   . LYS B 1 274 ? 133.970 117.117 158.546 1.00 86.26  ? 305 LYS B O   1 
ATOM   4630 C CB  . LYS B 1 274 ? 136.091 118.953 157.627 1.00 91.02  ? 305 LYS B CB  1 
ATOM   4631 N N   . GLU B 1 275 ? 133.279 117.299 156.416 1.00 86.80  ? 306 GLU B N   1 
ATOM   4632 C CA  . GLU B 1 275 ? 131.899 116.995 156.777 1.00 80.14  ? 306 GLU B CA  1 
ATOM   4633 C C   . GLU B 1 275 ? 131.724 115.488 156.960 1.00 74.59  ? 306 GLU B C   1 
ATOM   4634 O O   . GLU B 1 275 ? 132.526 114.677 156.493 1.00 78.22  ? 306 GLU B O   1 
ATOM   4635 C CB  . GLU B 1 275 ? 130.934 117.558 155.736 1.00 79.30  ? 306 GLU B CB  1 
ATOM   4636 C CG  . GLU B 1 275 ? 130.897 119.093 155.662 1.00 82.22  ? 306 GLU B CG  1 
ATOM   4637 C CD  . GLU B 1 275 ? 130.324 119.761 156.909 1.00 84.34  ? 306 GLU B CD  1 
ATOM   4638 O OE1 . GLU B 1 275 ? 129.436 119.174 157.565 1.00 86.34  ? 306 GLU B OE1 1 
ATOM   4639 O OE2 . GLU B 1 275 ? 130.769 120.881 157.236 1.00 80.52  ? 306 GLU B OE2 1 
ATOM   4640 N N   . ASN B 1 276 ? 130.649 115.110 157.652 1.00 71.57  ? 307 ASN B N   1 
ATOM   4641 C CA  . ASN B 1 276 ? 130.527 113.775 158.227 1.00 73.31  ? 307 ASN B CA  1 
ATOM   4642 C C   . ASN B 1 276 ? 129.767 112.793 157.341 1.00 67.67  ? 307 ASN B C   1 
ATOM   4643 O O   . ASN B 1 276 ? 129.614 111.627 157.721 1.00 62.27  ? 307 ASN B O   1 
ATOM   4644 C CB  . ASN B 1 276 ? 129.855 113.863 159.602 1.00 75.71  ? 307 ASN B CB  1 
ATOM   4645 C CG  . ASN B 1 276 ? 130.383 112.832 160.581 1.00 75.63  ? 307 ASN B CG  1 
ATOM   4646 O OD1 . ASN B 1 276 ? 131.308 112.081 160.271 1.00 74.90  ? 307 ASN B OD1 1 
ATOM   4647 N ND2 . ASN B 1 276 ? 129.790 112.785 161.768 1.00 73.66  ? 307 ASN B ND2 1 
ATOM   4648 N N   . GLY B 1 277 ? 129.300 113.215 156.168 1.00 65.67  ? 308 GLY B N   1 
ATOM   4649 C CA  . GLY B 1 277 ? 128.550 112.355 155.283 1.00 55.77  ? 308 GLY B CA  1 
ATOM   4650 C C   . GLY B 1 277 ? 129.457 111.458 154.458 1.00 51.25  ? 308 GLY B C   1 
ATOM   4651 O O   . GLY B 1 277 ? 130.680 111.612 154.443 1.00 55.15  ? 308 GLY B O   1 
ATOM   4652 N N   . THR B 1 278 ? 128.825 110.508 153.771 1.00 45.51  ? 309 THR B N   1 
ATOM   4653 C CA  . THR B 1 278 ? 129.561 109.609 152.894 1.00 42.22  ? 309 THR B CA  1 
ATOM   4654 C C   . THR B 1 278 ? 129.931 110.326 151.605 1.00 41.52  ? 309 THR B C   1 
ATOM   4655 O O   . THR B 1 278 ? 129.126 111.067 151.039 1.00 45.30  ? 309 THR B O   1 
ATOM   4656 C CB  . THR B 1 278 ? 128.732 108.369 152.581 1.00 42.57  ? 309 THR B CB  1 
ATOM   4657 O OG1 . THR B 1 278 ? 127.659 108.723 151.705 1.00 45.64  ? 309 THR B OG1 1 
ATOM   4658 C CG2 . THR B 1 278 ? 128.161 107.784 153.858 1.00 42.46  ? 309 THR B CG2 1 
ATOM   4659 N N   . LEU B 1 279 ? 131.156 110.097 151.130 1.00 37.57  ? 310 LEU B N   1 
ATOM   4660 C CA  . LEU B 1 279 ? 131.744 110.908 150.064 1.00 34.51  ? 310 LEU B CA  1 
ATOM   4661 C C   . LEU B 1 279 ? 132.002 110.002 148.864 1.00 34.79  ? 310 LEU B C   1 
ATOM   4662 O O   . LEU B 1 279 ? 132.593 108.931 148.995 1.00 40.15  ? 310 LEU B O   1 
ATOM   4663 C CB  . LEU B 1 279 ? 133.008 111.615 150.576 1.00 38.18  ? 310 LEU B CB  1 
ATOM   4664 C CG  . LEU B 1 279 ? 133.805 112.680 149.812 1.00 47.75  ? 310 LEU B CG  1 
ATOM   4665 C CD1 . LEU B 1 279 ? 134.488 113.555 150.842 1.00 59.23  ? 310 LEU B CD1 1 
ATOM   4666 C CD2 . LEU B 1 279 ? 134.877 112.119 148.887 1.00 45.31  ? 310 LEU B CD2 1 
ATOM   4667 N N   . PHE B 1 280 ? 131.543 110.440 147.691 1.00 34.05  ? 311 PHE B N   1 
ATOM   4668 C CA  . PHE B 1 280 ? 131.752 109.724 146.431 1.00 32.91  ? 311 PHE B CA  1 
ATOM   4669 C C   . PHE B 1 280 ? 132.616 110.583 145.516 1.00 35.89  ? 311 PHE B C   1 
ATOM   4670 O O   . PHE B 1 280 ? 132.131 111.397 144.729 1.00 40.49  ? 311 PHE B O   1 
ATOM   4671 C CB  . PHE B 1 280 ? 130.424 109.391 145.770 1.00 34.26  ? 311 PHE B CB  1 
ATOM   4672 C CG  . PHE B 1 280 ? 129.538 108.524 146.597 1.00 35.59  ? 311 PHE B CG  1 
ATOM   4673 C CD1 . PHE B 1 280 ? 129.732 107.150 146.607 1.00 35.05  ? 311 PHE B CD1 1 
ATOM   4674 C CD2 . PHE B 1 280 ? 128.504 109.074 147.355 1.00 38.93  ? 311 PHE B CD2 1 
ATOM   4675 C CE1 . PHE B 1 280 ? 128.927 106.325 147.372 1.00 35.48  ? 311 PHE B CE1 1 
ATOM   4676 C CE2 . PHE B 1 280 ? 127.683 108.253 148.127 1.00 40.02  ? 311 PHE B CE2 1 
ATOM   4677 C CZ  . PHE B 1 280 ? 127.900 106.877 148.129 1.00 38.44  ? 311 PHE B CZ  1 
ATOM   4678 N N   . SER B 1 281 ? 133.926 110.389 145.617 1.00 33.67  ? 312 SER B N   1 
ATOM   4679 C CA  . SER B 1 281 ? 134.851 111.162 144.803 1.00 35.80  ? 312 SER B CA  1 
ATOM   4680 C C   . SER B 1 281 ? 134.936 110.586 143.400 1.00 37.21  ? 312 SER B C   1 
ATOM   4681 O O   . SER B 1 281 ? 135.249 109.411 143.215 1.00 41.59  ? 312 SER B O   1 
ATOM   4682 C CB  . SER B 1 281 ? 136.234 111.173 145.441 1.00 41.01  ? 312 SER B CB  1 
ATOM   4683 O OG  . SER B 1 281 ? 137.162 111.843 144.609 1.00 47.53  ? 312 SER B OG  1 
ATOM   4684 N N   . VAL B 1 282 ? 134.643 111.413 142.403 1.00 39.18  ? 313 VAL B N   1 
ATOM   4685 C CA  . VAL B 1 282 ? 134.761 110.987 141.011 1.00 41.05  ? 313 VAL B CA  1 
ATOM   4686 C C   . VAL B 1 282 ? 135.892 111.773 140.356 1.00 45.11  ? 313 VAL B C   1 
ATOM   4687 O O   . VAL B 1 282 ? 135.716 112.964 140.063 1.00 53.50  ? 313 VAL B O   1 
ATOM   4688 C CB  . VAL B 1 282 ? 133.444 111.176 140.247 1.00 40.85  ? 313 VAL B CB  1 
ATOM   4689 C CG1 . VAL B 1 282 ? 133.577 110.655 138.832 1.00 44.08  ? 313 VAL B CG1 1 
ATOM   4690 C CG2 . VAL B 1 282 ? 132.295 110.484 140.957 1.00 39.49  ? 313 VAL B CG2 1 
ATOM   4691 N N   . PRO B 1 283 ? 137.070 111.179 140.150 1.00 41.76  ? 314 PRO B N   1 
ATOM   4692 C CA  . PRO B 1 283 ? 138.148 111.899 139.465 1.00 48.57  ? 314 PRO B CA  1 
ATOM   4693 C C   . PRO B 1 283 ? 137.893 112.014 137.971 1.00 54.56  ? 314 PRO B C   1 
ATOM   4694 O O   . PRO B 1 283 ? 137.414 111.077 137.330 1.00 52.62  ? 314 PRO B O   1 
ATOM   4695 C CB  . PRO B 1 283 ? 139.383 111.044 139.761 1.00 50.50  ? 314 PRO B CB  1 
ATOM   4696 C CG  . PRO B 1 283 ? 138.852 109.732 140.096 1.00 44.54  ? 314 PRO B CG  1 
ATOM   4697 C CD  . PRO B 1 283 ? 137.589 109.980 140.822 1.00 42.49  ? 314 PRO B CD  1 
ATOM   4698 N N   . THR B 1 284 ? 138.216 113.182 137.423 1.00 59.63  ? 315 THR B N   1 
ATOM   4699 C CA  . THR B 1 284 ? 138.010 113.480 136.014 1.00 59.99  ? 315 THR B CA  1 
ATOM   4700 C C   . THR B 1 284 ? 139.281 113.365 135.185 1.00 60.15  ? 315 THR B C   1 
ATOM   4701 O O   . THR B 1 284 ? 139.223 113.531 133.965 1.00 64.06  ? 315 THR B O   1 
ATOM   4702 C CB  . THR B 1 284 ? 137.423 114.883 135.858 1.00 65.76  ? 315 THR B CB  1 
ATOM   4703 O OG1 . THR B 1 284 ? 137.132 115.127 134.477 1.00 72.04  ? 315 THR B OG1 1 
ATOM   4704 C CG2 . THR B 1 284 ? 138.405 115.927 136.361 1.00 64.31  ? 315 THR B CG2 1 
ATOM   4705 N N   . ASP B 1 285 ? 140.421 113.092 135.811 1.00 59.34  ? 316 ASP B N   1 
ATOM   4706 C CA  . ASP B 1 285 ? 141.656 112.854 135.082 1.00 63.45  ? 316 ASP B CA  1 
ATOM   4707 C C   . ASP B 1 285 ? 142.385 111.696 135.743 1.00 66.44  ? 316 ASP B C   1 
ATOM   4708 O O   . ASP B 1 285 ? 141.815 110.955 136.546 1.00 69.08  ? 316 ASP B O   1 
ATOM   4709 C CB  . ASP B 1 285 ? 142.548 114.101 135.029 1.00 69.35  ? 316 ASP B CB  1 
ATOM   4710 C CG  . ASP B 1 285 ? 142.065 115.129 134.018 1.00 70.18  ? 316 ASP B CG  1 
ATOM   4711 O OD1 . ASP B 1 285 ? 141.760 114.742 132.870 1.00 69.65  ? 316 ASP B OD1 1 
ATOM   4712 O OD2 . ASP B 1 285 ? 142.002 116.326 134.369 1.00 68.67  ? 316 ASP B OD2 1 
ATOM   4713 N N   . ARG B 1 286 ? 143.654 111.538 135.372 1.00 66.26  ? 317 ARG B N   1 
ATOM   4714 C CA  . ARG B 1 286 ? 144.478 110.470 135.918 1.00 69.58  ? 317 ARG B CA  1 
ATOM   4715 C C   . ARG B 1 286 ? 144.878 110.776 137.355 1.00 72.85  ? 317 ARG B C   1 
ATOM   4716 O O   . ARG B 1 286 ? 145.173 111.921 137.705 1.00 72.74  ? 317 ARG B O   1 
ATOM   4717 C CB  . ARG B 1 286 ? 145.729 110.281 135.066 1.00 69.25  ? 317 ARG B CB  1 
ATOM   4718 C CG  . ARG B 1 286 ? 145.464 109.784 133.666 1.00 64.95  ? 317 ARG B CG  1 
ATOM   4719 C CD  . ARG B 1 286 ? 146.763 109.602 132.911 1.00 63.35  ? 317 ARG B CD  1 
ATOM   4720 N NE  . ARG B 1 286 ? 147.233 108.228 133.024 1.00 63.17  ? 317 ARG B NE  1 
ATOM   4721 C CZ  . ARG B 1 286 ? 147.389 107.403 132.000 1.00 62.47  ? 317 ARG B CZ  1 
ATOM   4722 N NH1 . ARG B 1 286 ? 147.148 107.788 130.759 1.00 58.55  ? 317 ARG B NH1 1 
ATOM   4723 N NH2 . ARG B 1 286 ? 147.796 106.159 132.228 1.00 61.02  ? 317 ARG B NH2 1 
ATOM   4724 N N   . THR B 1 287 ? 144.887 109.741 138.187 1.00 77.49  ? 318 THR B N   1 
ATOM   4725 C CA  . THR B 1 287 ? 145.234 109.921 139.585 1.00 78.48  ? 318 THR B CA  1 
ATOM   4726 C C   . THR B 1 287 ? 146.748 109.901 139.771 1.00 80.62  ? 318 THR B C   1 
ATOM   4727 O O   . THR B 1 287 ? 147.498 109.342 138.965 1.00 83.39  ? 318 THR B O   1 
ATOM   4728 C CB  . THR B 1 287 ? 144.597 108.826 140.438 1.00 77.45  ? 318 THR B CB  1 
ATOM   4729 O OG1 . THR B 1 287 ? 145.129 107.553 140.055 1.00 76.67  ? 318 THR B OG1 1 
ATOM   4730 C CG2 . THR B 1 287 ? 143.096 108.813 140.235 1.00 71.92  ? 318 THR B CG2 1 
ATOM   4731 N N   . ASP B 1 288 ? 147.192 110.519 140.861 1.00 80.00  ? 319 ASP B N   1 
ATOM   4732 C CA  . ASP B 1 288 ? 148.590 110.489 141.256 1.00 84.72  ? 319 ASP B CA  1 
ATOM   4733 C C   . ASP B 1 288 ? 148.633 110.249 142.754 1.00 83.41  ? 319 ASP B C   1 
ATOM   4734 O O   . ASP B 1 288 ? 147.593 110.152 143.404 1.00 83.01  ? 319 ASP B O   1 
ATOM   4735 C CB  . ASP B 1 288 ? 149.313 111.786 140.874 1.00 87.38  ? 319 ASP B CB  1 
ATOM   4736 C CG  . ASP B 1 288 ? 148.620 113.022 141.413 1.00 85.17  ? 319 ASP B CG  1 
ATOM   4737 O OD1 . ASP B 1 288 ? 147.372 113.049 141.427 1.00 82.10  ? 319 ASP B OD1 1 
ATOM   4738 O OD2 . ASP B 1 288 ? 149.325 113.969 141.819 1.00 86.42  ? 319 ASP B OD2 1 
ATOM   4739 N N   . ASP B 1 289 ? 149.845 110.250 143.319 1.00 85.84  ? 320 ASP B N   1 
ATOM   4740 C CA  . ASP B 1 289 ? 150.045 109.810 144.701 1.00 86.50  ? 320 ASP B CA  1 
ATOM   4741 C C   . ASP B 1 289 ? 149.618 110.872 145.711 1.00 83.90  ? 320 ASP B C   1 
ATOM   4742 O O   . ASP B 1 289 ? 149.465 110.578 146.902 1.00 82.14  ? 320 ASP B O   1 
ATOM   4743 C CB  . ASP B 1 289 ? 151.509 109.428 144.923 1.00 91.62  ? 320 ASP B CB  1 
ATOM   4744 C CG  . ASP B 1 289 ? 151.946 108.264 144.055 1.00 96.78  ? 320 ASP B CG  1 
ATOM   4745 O OD1 . ASP B 1 289 ? 151.073 107.640 143.417 1.00 94.70  ? 320 ASP B OD1 1 
ATOM   4746 O OD2 . ASP B 1 289 ? 153.159 107.973 144.011 1.00 103.22 ? 320 ASP B OD2 1 
ATOM   4747 N N   . GLU B 1 290 ? 149.439 112.115 145.257 1.00 83.15  ? 321 GLU B N   1 
ATOM   4748 C CA  . GLU B 1 290 ? 148.831 113.132 146.101 1.00 84.26  ? 321 GLU B CA  1 
ATOM   4749 C C   . GLU B 1 290 ? 147.342 112.871 146.289 1.00 81.62  ? 321 GLU B C   1 
ATOM   4750 O O   . GLU B 1 290 ? 146.788 113.171 147.351 1.00 80.49  ? 321 GLU B O   1 
ATOM   4751 C CB  . GLU B 1 290 ? 149.057 114.517 145.492 1.00 88.77  ? 321 GLU B CB  1 
ATOM   4752 C CG  . GLU B 1 290 ? 148.842 115.677 146.457 1.00 89.88  ? 321 GLU B CG  1 
ATOM   4753 C CD  . GLU B 1 290 ? 148.832 117.021 145.761 1.00 90.56  ? 321 GLU B CD  1 
ATOM   4754 O OE1 . GLU B 1 290 ? 149.011 117.052 144.527 1.00 89.71  ? 321 GLU B OE1 1 
ATOM   4755 O OE2 . GLU B 1 290 ? 148.630 118.045 146.445 1.00 91.95  ? 321 GLU B OE2 1 
ATOM   4756 N N   . PHE B 1 291 ? 146.682 112.300 145.275 1.00 79.51  ? 322 PHE B N   1 
ATOM   4757 C CA  . PHE B 1 291 ? 145.227 112.167 145.311 1.00 74.45  ? 322 PHE B CA  1 
ATOM   4758 C C   . PHE B 1 291 ? 144.780 111.015 146.207 1.00 75.07  ? 322 PHE B C   1 
ATOM   4759 O O   . PHE B 1 291 ? 143.779 111.133 146.915 1.00 76.49  ? 322 PHE B O   1 
ATOM   4760 C CB  . PHE B 1 291 ? 144.668 112.002 143.898 1.00 74.20  ? 322 PHE B CB  1 
ATOM   4761 C CG  . PHE B 1 291 ? 143.185 111.772 143.862 1.00 71.04  ? 322 PHE B CG  1 
ATOM   4762 C CD1 . PHE B 1 291 ? 142.312 112.800 144.222 1.00 70.74  ? 322 PHE B CD1 1 
ATOM   4763 C CD2 . PHE B 1 291 ? 142.661 110.541 143.465 1.00 73.65  ? 322 PHE B CD2 1 
ATOM   4764 C CE1 . PHE B 1 291 ? 140.933 112.607 144.195 1.00 70.25  ? 322 PHE B CE1 1 
ATOM   4765 C CE2 . PHE B 1 291 ? 141.283 110.332 143.430 1.00 70.23  ? 322 PHE B CE2 1 
ATOM   4766 C CZ  . PHE B 1 291 ? 140.421 111.370 143.797 1.00 66.98  ? 322 PHE B CZ  1 
ATOM   4767 N N   . LEU B 1 292 ? 145.530 109.904 146.233 1.00 78.10  ? 323 LEU B N   1 
ATOM   4768 C CA  . LEU B 1 292 ? 145.129 108.777 147.083 1.00 76.37  ? 323 LEU B CA  1 
ATOM   4769 C C   . LEU B 1 292 ? 145.506 108.987 148.549 1.00 75.06  ? 323 LEU B C   1 
ATOM   4770 O O   . LEU B 1 292 ? 145.059 108.230 149.418 1.00 70.93  ? 323 LEU B O   1 
ATOM   4771 C CB  . LEU B 1 292 ? 145.711 107.449 146.577 1.00 79.30  ? 323 LEU B CB  1 
ATOM   4772 C CG  . LEU B 1 292 ? 145.308 106.803 145.240 1.00 82.25  ? 323 LEU B CG  1 
ATOM   4773 C CD1 . LEU B 1 292 ? 146.134 107.235 144.076 1.00 78.04  ? 323 LEU B CD1 1 
ATOM   4774 C CD2 . LEU B 1 292 ? 145.385 105.290 145.340 1.00 83.46  ? 323 LEU B CD2 1 
ATOM   4775 N N   . ALA B 1 293 ? 146.326 109.994 148.851 1.00 78.38  ? 324 ALA B N   1 
ATOM   4776 C CA  . ALA B 1 293 ? 146.662 110.275 150.242 1.00 79.51  ? 324 ALA B CA  1 
ATOM   4777 C C   . ALA B 1 293 ? 145.752 111.347 150.837 1.00 79.50  ? 324 ALA B C   1 
ATOM   4778 O O   . ALA B 1 293 ? 145.494 111.344 152.046 1.00 80.09  ? 324 ALA B O   1 
ATOM   4779 C CB  . ALA B 1 293 ? 148.127 110.694 150.348 1.00 82.01  ? 324 ALA B CB  1 
ATOM   4780 N N   . ASP B 1 294 ? 145.257 112.269 150.012 1.00 79.97  ? 325 ASP B N   1 
ATOM   4781 C CA  . ASP B 1 294 ? 144.517 113.430 150.496 1.00 80.96  ? 325 ASP B CA  1 
ATOM   4782 C C   . ASP B 1 294 ? 143.016 113.204 150.624 1.00 78.11  ? 325 ASP B C   1 
ATOM   4783 O O   . ASP B 1 294 ? 142.304 114.141 150.997 1.00 80.92  ? 325 ASP B O   1 
ATOM   4784 C CB  . ASP B 1 294 ? 144.757 114.635 149.581 1.00 82.08  ? 325 ASP B CB  1 
ATOM   4785 C CG  . ASP B 1 294 ? 146.083 115.313 149.846 1.00 86.14  ? 325 ASP B CG  1 
ATOM   4786 O OD1 . ASP B 1 294 ? 146.744 114.961 150.845 1.00 86.83  ? 325 ASP B OD1 1 
ATOM   4787 O OD2 . ASP B 1 294 ? 146.468 116.197 149.054 1.00 87.17  ? 325 ASP B OD2 1 
ATOM   4788 N N   . LEU B 1 295 ? 142.516 112.017 150.304 1.00 72.41  ? 326 LEU B N   1 
ATOM   4789 C CA  . LEU B 1 295 ? 141.104 111.724 150.505 1.00 69.50  ? 326 LEU B CA  1 
ATOM   4790 C C   . LEU B 1 295 ? 140.811 111.518 151.991 1.00 69.07  ? 326 LEU B C   1 
ATOM   4791 O O   . LEU B 1 295 ? 141.717 111.168 152.755 1.00 70.25  ? 326 LEU B O   1 
ATOM   4792 C CB  . LEU B 1 295 ? 140.711 110.475 149.721 1.00 66.95  ? 326 LEU B CB  1 
ATOM   4793 C CG  . LEU B 1 295 ? 140.731 110.582 148.212 1.00 69.79  ? 326 LEU B CG  1 
ATOM   4794 C CD1 . LEU B 1 295 ? 140.499 109.232 147.658 1.00 64.93  ? 326 LEU B CD1 1 
ATOM   4795 C CD2 . LEU B 1 295 ? 139.636 111.502 147.750 1.00 67.71  ? 326 LEU B CD2 1 
ATOM   4796 N N   . PRO B 1 296 ? 139.571 111.733 152.437 1.00 62.56  ? 327 PRO B N   1 
ATOM   4797 C CA  . PRO B 1 296 ? 139.207 111.326 153.796 1.00 54.24  ? 327 PRO B CA  1 
ATOM   4798 C C   . PRO B 1 296 ? 139.083 109.816 153.920 1.00 53.72  ? 327 PRO B C   1 
ATOM   4799 O O   . PRO B 1 296 ? 139.015 109.080 152.934 1.00 56.10  ? 327 PRO B O   1 
ATOM   4800 C CB  . PRO B 1 296 ? 137.854 112.009 154.018 1.00 56.25  ? 327 PRO B CB  1 
ATOM   4801 C CG  . PRO B 1 296 ? 137.854 113.142 153.070 1.00 68.07  ? 327 PRO B CG  1 
ATOM   4802 C CD  . PRO B 1 296 ? 138.532 112.604 151.859 1.00 66.18  ? 327 PRO B CD  1 
ATOM   4803 N N   . ASN B 1 297 ? 139.086 109.364 155.169 1.00 55.92  ? 328 ASN B N   1 
ATOM   4804 C CA  . ASN B 1 297 ? 138.896 107.956 155.482 1.00 50.97  ? 328 ASN B CA  1 
ATOM   4805 C C   . ASN B 1 297 ? 137.452 107.545 155.210 1.00 46.95  ? 328 ASN B C   1 
ATOM   4806 O O   . ASN B 1 297 ? 136.519 108.316 155.458 1.00 51.52  ? 328 ASN B O   1 
ATOM   4807 C CB  . ASN B 1 297 ? 139.274 107.706 156.943 1.00 48.99  ? 328 ASN B CB  1 
ATOM   4808 C CG  . ASN B 1 297 ? 139.237 106.249 157.321 1.00 53.91  ? 328 ASN B CG  1 
ATOM   4809 O OD1 . ASN B 1 297 ? 139.478 105.376 156.493 1.00 59.13  ? 328 ASN B OD1 1 
ATOM   4810 N ND2 . ASN B 1 297 ? 138.944 105.974 158.585 1.00 53.67  ? 328 ASN B ND2 1 
ATOM   4811 N N   . ARG B 1 298 ? 137.303 106.318 154.676 1.00 41.63  ? 329 ARG B N   1 
ATOM   4812 C CA  . ARG B 1 298 ? 136.048 105.696 154.203 1.00 45.67  ? 329 ARG B CA  1 
ATOM   4813 C C   . ARG B 1 298 ? 135.338 106.544 153.148 1.00 42.69  ? 329 ARG B C   1 
ATOM   4814 O O   . ARG B 1 298 ? 134.119 106.723 153.178 1.00 46.80  ? 329 ARG B O   1 
ATOM   4815 C CB  . ARG B 1 298 ? 135.111 105.333 155.362 1.00 48.29  ? 329 ARG B CB  1 
ATOM   4816 C CG  . ARG B 1 298 ? 135.534 104.077 156.098 1.00 46.49  ? 329 ARG B CG  1 
ATOM   4817 C CD  . ARG B 1 298 ? 134.463 103.602 157.057 1.00 49.17  ? 329 ARG B CD  1 
ATOM   4818 N NE  . ARG B 1 298 ? 135.008 102.704 158.069 1.00 56.46  ? 329 ARG B NE  1 
ATOM   4819 C CZ  . ARG B 1 298 ? 134.289 102.125 159.020 1.00 59.80  ? 329 ARG B CZ  1 
ATOM   4820 N NH1 . ARG B 1 298 ? 132.985 102.324 159.120 1.00 62.37  ? 329 ARG B NH1 1 
ATOM   4821 N NH2 . ARG B 1 298 ? 134.893 101.322 159.891 1.00 54.31  ? 329 ARG B NH2 1 
ATOM   4822 N N   . ALA B 1 299 ? 136.114 107.063 152.202 1.00 34.09  ? 330 ALA B N   1 
ATOM   4823 C CA  . ALA B 1 299 ? 135.588 107.783 151.052 1.00 32.64  ? 330 ALA B CA  1 
ATOM   4824 C C   . ALA B 1 299 ? 135.570 106.851 149.853 1.00 32.42  ? 330 ALA B C   1 
ATOM   4825 O O   . ALA B 1 299 ? 136.396 105.940 149.764 1.00 36.82  ? 330 ALA B O   1 
ATOM   4826 C CB  . ALA B 1 299 ? 136.426 109.020 150.740 1.00 40.92  ? 330 ALA B CB  1 
ATOM   4827 N N   . PHE B 1 300 ? 134.632 107.075 148.936 1.00 30.49  ? 331 PHE B N   1 
ATOM   4828 C CA  . PHE B 1 300 ? 134.471 106.202 147.781 1.00 28.16  ? 331 PHE B CA  1 
ATOM   4829 C C   . PHE B 1 300 ? 135.058 106.867 146.543 1.00 32.27  ? 331 PHE B C   1 
ATOM   4830 O O   . PHE B 1 300 ? 134.823 108.055 146.302 1.00 36.93  ? 331 PHE B O   1 
ATOM   4831 C CB  . PHE B 1 300 ? 133.003 105.869 147.560 1.00 27.81  ? 331 PHE B CB  1 
ATOM   4832 C CG  . PHE B 1 300 ? 132.420 104.968 148.601 1.00 26.07  ? 331 PHE B CG  1 
ATOM   4833 C CD1 . PHE B 1 300 ? 132.493 103.586 148.456 1.00 25.11  ? 331 PHE B CD1 1 
ATOM   4834 C CD2 . PHE B 1 300 ? 131.778 105.505 149.717 1.00 28.17  ? 331 PHE B CD2 1 
ATOM   4835 C CE1 . PHE B 1 300 ? 131.947 102.742 149.420 1.00 25.80  ? 331 PHE B CE1 1 
ATOM   4836 C CE2 . PHE B 1 300 ? 131.229 104.677 150.687 1.00 30.70  ? 331 PHE B CE2 1 
ATOM   4837 C CZ  . PHE B 1 300 ? 131.317 103.293 150.538 1.00 28.64  ? 331 PHE B CZ  1 
ATOM   4838 N N   . VAL B 1 301 ? 135.820 106.103 145.760 1.00 31.20  ? 332 VAL B N   1 
ATOM   4839 C CA  . VAL B 1 301 ? 136.532 106.607 144.589 1.00 28.44  ? 332 VAL B CA  1 
ATOM   4840 C C   . VAL B 1 301 ? 135.910 105.978 143.359 1.00 33.41  ? 332 VAL B C   1 
ATOM   4841 O O   . VAL B 1 301 ? 135.923 104.754 143.225 1.00 38.84  ? 332 VAL B O   1 
ATOM   4842 C CB  . VAL B 1 301 ? 138.022 106.248 144.638 1.00 28.66  ? 332 VAL B CB  1 
ATOM   4843 C CG1 . VAL B 1 301 ? 138.781 106.997 143.558 1.00 35.21  ? 332 VAL B CG1 1 
ATOM   4844 C CG2 . VAL B 1 301 ? 138.588 106.454 146.004 1.00 34.32  ? 332 VAL B CG2 1 
ATOM   4845 N N   . LEU B 1 302 ? 135.412 106.787 142.430 1.00 34.42  ? 333 LEU B N   1 
ATOM   4846 C CA  . LEU B 1 302 ? 134.791 106.248 141.217 1.00 34.40  ? 333 LEU B CA  1 
ATOM   4847 C C   . LEU B 1 302 ? 135.700 106.556 140.029 1.00 37.71  ? 333 LEU B C   1 
ATOM   4848 O O   . LEU B 1 302 ? 135.601 107.610 139.404 1.00 39.74  ? 333 LEU B O   1 
ATOM   4849 C CB  . LEU B 1 302 ? 133.385 106.801 141.017 1.00 33.82  ? 333 LEU B CB  1 
ATOM   4850 C CG  . LEU B 1 302 ? 132.234 106.170 141.817 1.00 38.32  ? 333 LEU B CG  1 
ATOM   4851 C CD1 . LEU B 1 302 ? 132.066 106.749 143.220 1.00 37.44  ? 333 LEU B CD1 1 
ATOM   4852 C CD2 . LEU B 1 302 ? 130.928 106.241 141.051 1.00 43.47  ? 333 LEU B CD2 1 
ATOM   4853 N N   . MET B 1 303 ? 136.580 105.608 139.705 1.00 38.46  ? 334 MET B N   1 
ATOM   4854 C CA  . MET B 1 303 ? 137.600 105.789 138.683 1.00 38.91  ? 334 MET B CA  1 
ATOM   4855 C C   . MET B 1 303 ? 137.692 104.559 137.798 1.00 44.46  ? 334 MET B C   1 
ATOM   4856 O O   . MET B 1 303 ? 137.185 103.492 138.150 1.00 50.38  ? 334 MET B O   1 
ATOM   4857 C CB  . MET B 1 303 ? 138.965 106.062 139.310 1.00 40.95  ? 334 MET B CB  1 
ATOM   4858 C CG  . MET B 1 303 ? 139.526 104.915 140.119 1.00 40.68  ? 334 MET B CG  1 
ATOM   4859 S SD  . MET B 1 303 ? 141.139 105.327 140.799 1.00 65.97  ? 334 MET B SD  1 
ATOM   4860 C CE  . MET B 1 303 ? 142.144 105.278 139.320 1.00 61.40  ? 334 MET B CE  1 
ATOM   4861 N N   . GLU B 1 304 ? 138.349 104.711 136.652 1.00 44.83  ? 335 GLU B N   1 
ATOM   4862 C CA  . GLU B 1 304 ? 138.566 103.591 135.750 1.00 44.60  ? 335 GLU B CA  1 
ATOM   4863 C C   . GLU B 1 304 ? 139.997 103.088 135.858 1.00 48.22  ? 335 GLU B C   1 
ATOM   4864 O O   . GLU B 1 304 ? 140.911 103.827 136.227 1.00 55.19  ? 335 GLU B O   1 
ATOM   4865 C CB  . GLU B 1 304 ? 138.283 104.002 134.313 1.00 43.83  ? 335 GLU B CB  1 
ATOM   4866 C CG  . GLU B 1 304 ? 138.823 105.364 133.966 1.00 46.63  ? 335 GLU B CG  1 
ATOM   4867 C CD  . GLU B 1 304 ? 138.448 105.794 132.568 1.00 52.49  ? 335 GLU B CD  1 
ATOM   4868 O OE1 . GLU B 1 304 ? 137.842 104.981 131.842 1.00 52.62  ? 335 GLU B OE1 1 
ATOM   4869 O OE2 . GLU B 1 304 ? 138.756 106.945 132.194 1.00 54.15  ? 335 GLU B OE2 1 
ATOM   4870 N N   . ASN B 1 305 ? 140.188 101.818 135.522 1.00 47.81  ? 336 ASN B N   1 
ATOM   4871 C CA  . ASN B 1 305 ? 141.495 101.181 135.583 1.00 53.07  ? 336 ASN B CA  1 
ATOM   4872 C C   . ASN B 1 305 ? 142.345 101.626 134.402 1.00 58.61  ? 336 ASN B C   1 
ATOM   4873 O O   . ASN B 1 305 ? 141.900 101.559 133.255 1.00 58.37  ? 336 ASN B O   1 
ATOM   4874 C CB  . ASN B 1 305 ? 141.368 99.662  135.572 1.00 50.50  ? 336 ASN B CB  1 
ATOM   4875 C CG  . ASN B 1 305 ? 140.883 99.117  136.875 1.00 57.85  ? 336 ASN B CG  1 
ATOM   4876 O OD1 . ASN B 1 305 ? 141.142 99.683  137.934 1.00 61.31  ? 336 ASN B OD1 1 
ATOM   4877 N ND2 . ASN B 1 305 ? 140.206 97.984  136.815 1.00 65.06  ? 336 ASN B ND2 1 
ATOM   4878 N N   . GLU B 1 306 ? 143.569 102.058 134.683 1.00 55.93  ? 337 GLU B N   1 
ATOM   4879 C CA  . GLU B 1 306 ? 144.542 102.254 133.622 1.00 52.20  ? 337 GLU B CA  1 
ATOM   4880 C C   . GLU B 1 306 ? 145.097 100.904 133.189 1.00 54.41  ? 337 GLU B C   1 
ATOM   4881 O O   . GLU B 1 306 ? 145.563 100.121 134.020 1.00 55.32  ? 337 GLU B O   1 
ATOM   4882 C CB  . GLU B 1 306 ? 145.666 103.168 134.095 1.00 52.77  ? 337 GLU B CB  1 
ATOM   4883 C CG  . GLU B 1 306 ? 145.200 104.543 134.531 1.00 58.92  ? 337 GLU B CG  1 
ATOM   4884 C CD  . GLU B 1 306 ? 146.261 105.302 135.303 1.00 67.69  ? 337 GLU B CD  1 
ATOM   4885 O OE1 . GLU B 1 306 ? 145.898 106.088 136.202 1.00 71.77  ? 337 GLU B OE1 1 
ATOM   4886 O OE2 . GLU B 1 306 ? 147.460 105.111 135.012 1.00 64.58  ? 337 GLU B OE2 1 
ATOM   4887 N N   . ILE B 1 307 ? 145.035 100.626 131.886 1.00 52.23  ? 338 ILE B N   1 
ATOM   4888 C CA  . ILE B 1 307 ? 145.462 99.328  131.380 1.00 49.27  ? 338 ILE B CA  1 
ATOM   4889 C C   . ILE B 1 307 ? 146.946 99.372  131.045 1.00 52.27  ? 338 ILE B C   1 
ATOM   4890 O O   . ILE B 1 307 ? 147.376 100.080 130.130 1.00 55.90  ? 338 ILE B O   1 
ATOM   4891 C CB  . ILE B 1 307 ? 144.643 98.941  130.140 1.00 45.31  ? 338 ILE B CB  1 
ATOM   4892 C CG1 . ILE B 1 307 ? 143.167 98.841  130.482 1.00 47.75  ? 338 ILE B CG1 1 
ATOM   4893 C CG2 . ILE B 1 307 ? 145.110 97.605  129.610 1.00 45.86  ? 338 ILE B CG2 1 
ATOM   4894 C CD1 . ILE B 1 307 ? 142.300 98.733  129.270 1.00 50.73  ? 338 ILE B CD1 1 
ATOM   4895 N N   . ASP B 1 308 ? 147.735 98.584  131.763 1.00 51.10  ? 339 ASP B N   1 
ATOM   4896 C CA  . ASP B 1 308 ? 149.186 98.606  131.641 1.00 52.28  ? 339 ASP B CA  1 
ATOM   4897 C C   . ASP B 1 308 ? 149.607 97.794  130.423 1.00 54.60  ? 339 ASP B C   1 
ATOM   4898 O O   . ASP B 1 308 ? 149.283 96.607  130.324 1.00 60.18  ? 339 ASP B O   1 
ATOM   4899 C CB  . ASP B 1 308 ? 149.840 98.063  132.908 1.00 55.30  ? 339 ASP B CB  1 
ATOM   4900 C CG  . ASP B 1 308 ? 150.061 99.137  133.951 1.00 61.08  ? 339 ASP B CG  1 
ATOM   4901 O OD1 . ASP B 1 308 ? 149.433 99.058  135.027 1.00 64.66  ? 339 ASP B OD1 1 
ATOM   4902 O OD2 . ASP B 1 308 ? 150.864 100.059 133.697 1.00 60.82  ? 339 ASP B OD2 1 
ATOM   4903 N N   . LEU B 1 309 ? 150.329 98.436  129.506 1.00 51.67  ? 340 LEU B N   1 
ATOM   4904 C CA  . LEU B 1 309 ? 150.790 97.800  128.277 1.00 52.00  ? 340 LEU B CA  1 
ATOM   4905 C C   . LEU B 1 309 ? 152.202 97.271  128.483 1.00 55.92  ? 340 LEU B C   1 
ATOM   4906 O O   . LEU B 1 309 ? 153.111 98.040  128.807 1.00 59.10  ? 340 LEU B O   1 
ATOM   4907 C CB  . LEU B 1 309 ? 150.776 98.795  127.119 1.00 48.59  ? 340 LEU B CB  1 
ATOM   4908 C CG  . LEU B 1 309 ? 149.505 99.592  126.843 1.00 48.38  ? 340 LEU B CG  1 
ATOM   4909 C CD1 . LEU B 1 309 ? 149.727 100.490 125.647 1.00 46.72  ? 340 LEU B CD1 1 
ATOM   4910 C CD2 . LEU B 1 309 ? 148.324 98.673  126.607 1.00 47.85  ? 340 LEU B CD2 1 
ATOM   4911 N N   . SER B 1 310 ? 152.390 95.964  128.308 1.00 59.11  ? 341 SER B N   1 
ATOM   4912 C CA  . SER B 1 310 ? 153.736 95.411  128.391 1.00 62.67  ? 341 SER B CA  1 
ATOM   4913 C C   . SER B 1 310 ? 154.167 94.735  127.094 1.00 68.02  ? 341 SER B C   1 
ATOM   4914 O O   . SER B 1 310 ? 155.198 95.092  126.518 1.00 70.12  ? 341 SER B O   1 
ATOM   4915 C CB  . SER B 1 310 ? 153.830 94.422  129.552 1.00 66.69  ? 341 SER B CB  1 
ATOM   4916 O OG  . SER B 1 310 ? 155.089 93.771  129.563 1.00 66.30  ? 341 SER B OG  1 
ATOM   4917 N N   . THR B 1 311 ? 153.394 93.752  126.628 1.00 70.59  ? 342 THR B N   1 
ATOM   4918 C CA  . THR B 1 311 ? 153.733 92.995  125.426 1.00 72.44  ? 342 THR B CA  1 
ATOM   4919 C C   . THR B 1 311 ? 152.542 92.983  124.479 1.00 72.32  ? 342 THR B C   1 
ATOM   4920 O O   . THR B 1 311 ? 151.435 93.398  124.831 1.00 70.60  ? 342 THR B O   1 
ATOM   4921 C CB  . THR B 1 311 ? 154.158 91.540  125.722 1.00 73.48  ? 342 THR B CB  1 
ATOM   4922 O OG1 . THR B 1 311 ? 153.086 90.834  126.357 1.00 74.61  ? 342 THR B OG1 1 
ATOM   4923 C CG2 . THR B 1 311 ? 155.437 91.443  126.562 1.00 68.26  ? 342 THR B CG2 1 
ATOM   4924 N N   . ALA B 1 312 ? 152.791 92.498  123.259 1.00 71.28  ? 343 ALA B N   1 
ATOM   4925 C CA  . ALA B 1 312 ? 151.769 92.521  122.219 1.00 69.49  ? 343 ALA B CA  1 
ATOM   4926 C C   . ALA B 1 312 ? 150.918 91.260  122.216 1.00 72.79  ? 343 ALA B C   1 
ATOM   4927 O O   . ALA B 1 312 ? 149.875 91.227  121.556 1.00 75.22  ? 343 ALA B O   1 
ATOM   4928 C CB  . ALA B 1 312 ? 152.417 92.706  120.851 1.00 68.32  ? 343 ALA B CB  1 
ATOM   4929 N N   . VAL B 1 313 ? 151.334 90.216  122.939 1.00 74.42  ? 344 VAL B N   1 
ATOM   4930 C CA  . VAL B 1 313 ? 150.555 88.979  122.965 1.00 77.95  ? 344 VAL B CA  1 
ATOM   4931 C C   . VAL B 1 313 ? 149.411 89.083  123.967 1.00 77.91  ? 344 VAL B C   1 
ATOM   4932 O O   . VAL B 1 313 ? 148.470 88.281  123.945 1.00 74.90  ? 344 VAL B O   1 
ATOM   4933 C CB  . VAL B 1 313 ? 151.464 87.774  123.266 1.00 78.44  ? 344 VAL B CB  1 
ATOM   4934 C CG1 . VAL B 1 313 ? 152.302 87.427  122.049 1.00 77.23  ? 344 VAL B CG1 1 
ATOM   4935 C CG2 . VAL B 1 313 ? 152.354 88.071  124.458 1.00 78.70  ? 344 VAL B CG2 1 
ATOM   4936 N N   . GLU B 1 314 ? 149.475 90.073  124.862 1.00 77.83  ? 345 GLU B N   1 
ATOM   4937 C CA  . GLU B 1 314 ? 148.382 90.318  125.795 1.00 75.04  ? 345 GLU B CA  1 
ATOM   4938 C C   . GLU B 1 314 ? 147.256 91.113  125.143 1.00 73.27  ? 345 GLU B C   1 
ATOM   4939 O O   . GLU B 1 314 ? 146.153 91.196  125.691 1.00 76.38  ? 345 GLU B O   1 
ATOM   4940 C CB  . GLU B 1 314 ? 148.912 91.057  127.021 1.00 73.26  ? 345 GLU B CB  1 
ATOM   4941 C CG  . GLU B 1 314 ? 150.047 90.344  127.728 1.00 75.09  ? 345 GLU B CG  1 
ATOM   4942 C CD  . GLU B 1 314 ? 150.777 91.243  128.708 1.00 77.49  ? 345 GLU B CD  1 
ATOM   4943 O OE1 . GLU B 1 314 ? 150.440 92.443  128.781 1.00 73.50  ? 345 GLU B OE1 1 
ATOM   4944 O OE2 . GLU B 1 314 ? 151.694 90.751  129.400 1.00 79.15  ? 345 GLU B OE2 1 
ATOM   4945 N N   . LEU B 1 315 ? 147.520 91.727  123.985 1.00 71.02  ? 346 LEU B N   1 
ATOM   4946 C CA  . LEU B 1 315 ? 146.508 92.560  123.342 1.00 68.76  ? 346 LEU B CA  1 
ATOM   4947 C C   . LEU B 1 315 ? 145.577 91.732  122.466 1.00 72.53  ? 346 LEU B C   1 
ATOM   4948 O O   . LEU B 1 315 ? 144.363 91.962  122.453 1.00 79.23  ? 346 LEU B O   1 
ATOM   4949 C CB  . LEU B 1 315 ? 147.173 93.663  122.524 1.00 65.07  ? 346 LEU B CB  1 
ATOM   4950 C CG  . LEU B 1 315 ? 148.324 94.420  123.185 1.00 67.24  ? 346 LEU B CG  1 
ATOM   4951 C CD1 . LEU B 1 315 ? 148.977 95.353  122.193 1.00 64.17  ? 346 LEU B CD1 1 
ATOM   4952 C CD2 . LEU B 1 315 ? 147.847 95.200  124.387 1.00 65.81  ? 346 LEU B CD2 1 
ATOM   4953 N N   . ASP B 1 316 ? 146.126 90.774  121.716 1.00 72.11  ? 347 ASP B N   1 
ATOM   4954 C CA  . ASP B 1 316 ? 145.336 89.927  120.831 1.00 70.29  ? 347 ASP B CA  1 
ATOM   4955 C C   . ASP B 1 316 ? 146.060 88.610  120.601 1.00 72.11  ? 347 ASP B C   1 
ATOM   4956 O O   . ASP B 1 316 ? 147.289 88.537  120.691 1.00 73.57  ? 347 ASP B O   1 
ATOM   4957 C CB  . ASP B 1 316 ? 145.068 90.607  119.484 1.00 71.51  ? 347 ASP B CB  1 
ATOM   4958 C CG  . ASP B 1 316 ? 143.849 90.054  118.783 1.00 75.04  ? 347 ASP B CG  1 
ATOM   4959 O OD1 . ASP B 1 316 ? 143.110 89.286  119.425 1.00 73.84  ? 347 ASP B OD1 1 
ATOM   4960 O OD2 . ASP B 1 316 ? 143.627 90.386  117.600 1.00 78.43  ? 347 ASP B OD2 1 
ATOM   4961 N N   . ALA B 1 317 ? 145.283 87.569  120.288 1.00 69.92  ? 348 ALA B N   1 
ATOM   4962 C CA  . ALA B 1 317 ? 145.870 86.288  119.907 1.00 70.53  ? 348 ALA B CA  1 
ATOM   4963 C C   . ALA B 1 317 ? 146.385 86.314  118.473 1.00 73.51  ? 348 ALA B C   1 
ATOM   4964 O O   . ALA B 1 317 ? 147.206 85.471  118.092 1.00 71.12  ? 348 ALA B O   1 
ATOM   4965 C CB  . ALA B 1 317 ? 144.849 85.169  120.089 1.00 70.92  ? 348 ALA B CB  1 
ATOM   4966 N N   . THR B 1 318 ? 145.882 87.241  117.657 1.00 76.96  ? 349 THR B N   1 
ATOM   4967 C CA  . THR B 1 318 ? 146.471 87.514  116.353 1.00 74.93  ? 349 THR B CA  1 
ATOM   4968 C C   . THR B 1 318 ? 147.841 88.165  116.551 1.00 75.17  ? 349 THR B C   1 
ATOM   4969 O O   . THR B 1 318 ? 147.953 89.116  117.335 1.00 74.97  ? 349 THR B O   1 
ATOM   4970 C CB  . THR B 1 318 ? 145.551 88.435  115.546 1.00 70.45  ? 349 THR B CB  1 
ATOM   4971 O OG1 . THR B 1 318 ? 144.260 87.829  115.419 1.00 70.83  ? 349 THR B OG1 1 
ATOM   4972 C CG2 . THR B 1 318 ? 146.101 88.683  114.155 1.00 71.31  ? 349 THR B CG2 1 
ATOM   4973 N N   . PRO B 1 319 ? 148.904 87.653  115.911 1.00 75.42  ? 350 PRO B N   1 
ATOM   4974 C CA  . PRO B 1 319 ? 150.260 88.145  116.216 1.00 74.91  ? 350 PRO B CA  1 
ATOM   4975 C C   . PRO B 1 319 ? 150.552 89.524  115.634 1.00 73.21  ? 350 PRO B C   1 
ATOM   4976 O O   . PRO B 1 319 ? 150.731 89.695  114.427 1.00 71.91  ? 350 PRO B O   1 
ATOM   4977 C CB  . PRO B 1 319 ? 151.171 87.069  115.610 1.00 75.63  ? 350 PRO B CB  1 
ATOM   4978 C CG  . PRO B 1 319 ? 150.339 86.377  114.591 1.00 75.64  ? 350 PRO B CG  1 
ATOM   4979 C CD  . PRO B 1 319 ? 148.948 86.406  115.119 1.00 74.18  ? 350 PRO B CD  1 
ATOM   4980 N N   . THR B 1 320 ? 150.587 90.515  116.522 1.00 72.35  ? 351 THR B N   1 
ATOM   4981 C CA  . THR B 1 320 ? 150.894 91.890  116.162 1.00 67.00  ? 351 THR B CA  1 
ATOM   4982 C C   . THR B 1 320 ? 152.154 92.309  116.906 1.00 66.74  ? 351 THR B C   1 
ATOM   4983 O O   . THR B 1 320 ? 152.814 91.496  117.557 1.00 66.28  ? 351 THR B O   1 
ATOM   4984 C CB  . THR B 1 320 ? 149.737 92.839  116.494 1.00 63.67  ? 351 THR B CB  1 
ATOM   4985 O OG1 . THR B 1 320 ? 149.423 92.749  117.889 1.00 61.28  ? 351 THR B OG1 1 
ATOM   4986 C CG2 . THR B 1 320 ? 148.500 92.485  115.690 1.00 64.28  ? 351 THR B CG2 1 
ATOM   4987 N N   . ALA B 1 321 ? 152.486 93.594  116.804 1.00 65.86  ? 352 ALA B N   1 
ATOM   4988 C CA  . ALA B 1 321 ? 153.668 94.145  117.453 1.00 64.04  ? 352 ALA B CA  1 
ATOM   4989 C C   . ALA B 1 321 ? 153.311 95.442  118.159 1.00 60.78  ? 352 ALA B C   1 
ATOM   4990 O O   . ALA B 1 321 ? 152.648 96.307  117.581 1.00 59.25  ? 352 ALA B O   1 
ATOM   4991 C CB  . ALA B 1 321 ? 154.792 94.390  116.443 1.00 62.29  ? 352 ALA B CB  1 
ATOM   4992 N N   . LEU B 1 322 ? 153.748 95.570  119.406 1.00 60.99  ? 353 LEU B N   1 
ATOM   4993 C CA  . LEU B 1 322 ? 153.575 96.808  120.150 1.00 62.29  ? 353 LEU B CA  1 
ATOM   4994 C C   . LEU B 1 322 ? 154.827 97.663  120.002 1.00 64.38  ? 353 LEU B C   1 
ATOM   4995 O O   . LEU B 1 322 ? 155.949 97.146  120.004 1.00 67.13  ? 353 LEU B O   1 
ATOM   4996 C CB  . LEU B 1 322 ? 153.294 96.509  121.622 1.00 63.62  ? 353 LEU B CB  1 
ATOM   4997 C CG  . LEU B 1 322 ? 152.874 97.660  122.535 1.00 61.91  ? 353 LEU B CG  1 
ATOM   4998 C CD1 . LEU B 1 322 ? 151.529 98.204  122.110 1.00 53.86  ? 353 LEU B CD1 1 
ATOM   4999 C CD2 . LEU B 1 322 ? 152.833 97.204  123.974 1.00 62.76  ? 353 LEU B CD2 1 
ATOM   5000 N N   . ASP B 1 323 ? 154.627 98.970  119.849 1.00 61.59  ? 354 ASP B N   1 
ATOM   5001 C CA  . ASP B 1 323 ? 155.714 99.893  119.567 1.00 63.74  ? 354 ASP B CA  1 
ATOM   5002 C C   . ASP B 1 323 ? 156.551 100.150 120.818 1.00 65.54  ? 354 ASP B C   1 
ATOM   5003 O O   . ASP B 1 323 ? 156.096 99.975  121.949 1.00 66.32  ? 354 ASP B O   1 
ATOM   5004 C CB  . ASP B 1 323 ? 155.152 101.203 119.025 1.00 61.05  ? 354 ASP B CB  1 
ATOM   5005 C CG  . ASP B 1 323 ? 154.603 101.054 117.624 1.00 67.96  ? 354 ASP B CG  1 
ATOM   5006 O OD1 . ASP B 1 323 ? 155.042 100.131 116.906 1.00 73.71  ? 354 ASP B OD1 1 
ATOM   5007 O OD2 . ASP B 1 323 ? 153.711 101.839 117.248 1.00 67.22  ? 354 ASP B OD2 1 
ATOM   5008 N N   . GLU B 1 324 ? 157.791 100.600 120.601 1.00 67.70  ? 355 GLU B N   1 
ATOM   5009 C CA  . GLU B 1 324 ? 158.743 100.722 121.704 1.00 69.03  ? 355 GLU B CA  1 
ATOM   5010 C C   . GLU B 1 324 ? 158.530 102.004 122.501 1.00 65.30  ? 355 GLU B C   1 
ATOM   5011 O O   . GLU B 1 324 ? 159.099 102.170 123.585 1.00 66.12  ? 355 GLU B O   1 
ATOM   5012 C CB  . GLU B 1 324 ? 160.173 100.657 121.171 1.00 75.89  ? 355 GLU B CB  1 
ATOM   5013 C CG  . GLU B 1 324 ? 160.523 99.330  120.519 1.00 81.20  ? 355 GLU B CG  1 
ATOM   5014 C CD  . GLU B 1 324 ? 161.944 99.292  119.996 1.00 94.63  ? 355 GLU B CD  1 
ATOM   5015 O OE1 . GLU B 1 324 ? 162.670 100.294 120.169 1.00 96.54  ? 355 GLU B OE1 1 
ATOM   5016 O OE2 . GLU B 1 324 ? 162.334 98.262  119.409 1.00 100.87 ? 355 GLU B OE2 1 
ATOM   5017 N N   . ILE B 1 325 ? 157.726 102.928 121.974 1.00 61.81  ? 356 ILE B N   1 
ATOM   5018 C CA  . ILE B 1 325 ? 157.336 104.113 122.725 1.00 60.96  ? 356 ILE B CA  1 
ATOM   5019 C C   . ILE B 1 325 ? 156.175 103.780 123.668 1.00 60.98  ? 356 ILE B C   1 
ATOM   5020 O O   . ILE B 1 325 ? 155.965 104.459 124.681 1.00 61.72  ? 356 ILE B O   1 
ATOM   5021 C CB  . ILE B 1 325 ? 157.034 105.247 121.709 1.00 61.21  ? 356 ILE B CB  1 
ATOM   5022 C CG1 . ILE B 1 325 ? 156.871 106.629 122.354 1.00 59.99  ? 356 ILE B CG1 1 
ATOM   5023 C CG2 . ILE B 1 325 ? 155.861 104.893 120.801 1.00 62.07  ? 356 ILE B CG2 1 
ATOM   5024 C CD1 . ILE B 1 325 ? 156.769 107.752 121.344 1.00 58.91  ? 356 ILE B CD1 1 
ATOM   5025 N N   . LEU B 1 326 ? 155.462 102.682 123.407 1.00 58.39  ? 357 LEU B N   1 
ATOM   5026 C CA  . LEU B 1 326 ? 154.283 102.313 124.181 1.00 54.41  ? 357 LEU B CA  1 
ATOM   5027 C C   . LEU B 1 326 ? 154.524 101.204 125.195 1.00 56.01  ? 357 LEU B C   1 
ATOM   5028 O O   . LEU B 1 326 ? 153.613 100.900 125.970 1.00 57.76  ? 357 LEU B O   1 
ATOM   5029 C CB  . LEU B 1 326 ? 153.154 101.876 123.254 1.00 54.26  ? 357 LEU B CB  1 
ATOM   5030 C CG  . LEU B 1 326 ? 152.404 102.977 122.528 1.00 51.40  ? 357 LEU B CG  1 
ATOM   5031 C CD1 . LEU B 1 326 ? 151.756 102.387 121.308 1.00 48.42  ? 357 LEU B CD1 1 
ATOM   5032 C CD2 . LEU B 1 326 ? 151.373 103.583 123.454 1.00 47.44  ? 357 LEU B CD2 1 
ATOM   5033 N N   . ILE B 1 327 ? 155.699 100.577 125.206 1.00 58.26  ? 358 ILE B N   1 
ATOM   5034 C CA  . ILE B 1 327 ? 155.955 99.521  126.176 1.00 57.44  ? 358 ILE B CA  1 
ATOM   5035 C C   . ILE B 1 327 ? 156.292 100.143 127.522 1.00 56.80  ? 358 ILE B C   1 
ATOM   5036 O O   . ILE B 1 327 ? 157.255 100.909 127.654 1.00 57.32  ? 358 ILE B O   1 
ATOM   5037 C CB  . ILE B 1 327 ? 157.074 98.589  125.680 1.00 59.52  ? 358 ILE B CB  1 
ATOM   5038 C CG1 . ILE B 1 327 ? 156.593 97.796  124.468 1.00 59.75  ? 358 ILE B CG1 1 
ATOM   5039 C CG2 . ILE B 1 327 ? 157.517 97.629  126.773 1.00 59.99  ? 358 ILE B CG2 1 
ATOM   5040 C CD1 . ILE B 1 327 ? 157.688 97.038  123.758 1.00 63.84  ? 358 ILE B CD1 1 
ATOM   5041 N N   . GLY B 1 328 ? 155.485 99.823  128.529 1.00 55.80  ? 359 GLY B N   1 
ATOM   5042 C CA  . GLY B 1 328 ? 155.659 100.407 129.840 1.00 55.39  ? 359 GLY B CA  1 
ATOM   5043 C C   . GLY B 1 328 ? 154.765 101.590 130.124 1.00 56.41  ? 359 GLY B C   1 
ATOM   5044 O O   . GLY B 1 328 ? 154.977 102.291 131.116 1.00 63.70  ? 359 GLY B O   1 
ATOM   5045 N N   . LYS B 1 329 ? 153.768 101.835 129.280 1.00 52.32  ? 360 LYS B N   1 
ATOM   5046 C CA  . LYS B 1 329 ? 152.849 102.946 129.461 1.00 55.16  ? 360 LYS B CA  1 
ATOM   5047 C C   . LYS B 1 329 ? 151.455 102.398 129.714 1.00 56.46  ? 360 LYS B C   1 
ATOM   5048 O O   . LYS B 1 329 ? 151.181 101.220 129.478 1.00 57.21  ? 360 LYS B O   1 
ATOM   5049 C CB  . LYS B 1 329 ? 152.843 103.873 128.243 1.00 56.72  ? 360 LYS B CB  1 
ATOM   5050 C CG  . LYS B 1 329 ? 154.227 104.349 127.842 1.00 59.77  ? 360 LYS B CG  1 
ATOM   5051 C CD  . LYS B 1 329 ? 154.503 105.758 128.313 1.00 61.17  ? 360 LYS B CD  1 
ATOM   5052 C CE  . LYS B 1 329 ? 155.950 106.132 128.069 1.00 64.83  ? 360 LYS B CE  1 
ATOM   5053 N NZ  . LYS B 1 329 ? 156.289 107.441 128.689 1.00 77.57  ? 360 LYS B NZ  1 
ATOM   5054 N N   . SER B 1 330 ? 150.570 103.259 130.207 1.00 56.44  ? 361 SER B N   1 
ATOM   5055 C CA  . SER B 1 330 ? 149.219 102.858 130.570 1.00 52.55  ? 361 SER B CA  1 
ATOM   5056 C C   . SER B 1 330 ? 148.209 103.734 129.846 1.00 50.62  ? 361 SER B C   1 
ATOM   5057 O O   . SER B 1 330 ? 148.438 104.933 129.669 1.00 53.09  ? 361 SER B O   1 
ATOM   5058 C CB  . SER B 1 330 ? 149.005 102.934 132.082 1.00 57.86  ? 361 SER B CB  1 
ATOM   5059 O OG  . SER B 1 330 ? 149.498 104.151 132.608 1.00 63.99  ? 361 SER B OG  1 
ATOM   5060 N N   . VAL B 1 331 ? 147.093 103.134 129.437 1.00 49.51  ? 362 VAL B N   1 
ATOM   5061 C CA  . VAL B 1 331 ? 146.089 103.795 128.613 1.00 49.29  ? 362 VAL B CA  1 
ATOM   5062 C C   . VAL B 1 331 ? 144.792 103.886 129.400 1.00 48.21  ? 362 VAL B C   1 
ATOM   5063 O O   . VAL B 1 331 ? 144.588 103.135 130.357 1.00 53.37  ? 362 VAL B O   1 
ATOM   5064 C CB  . VAL B 1 331 ? 145.870 103.051 127.284 1.00 47.40  ? 362 VAL B CB  1 
ATOM   5065 C CG1 . VAL B 1 331 ? 147.105 103.148 126.439 1.00 48.61  ? 362 VAL B CG1 1 
ATOM   5066 C CG2 . VAL B 1 331 ? 145.531 101.598 127.516 1.00 45.79  ? 362 VAL B CG2 1 
ATOM   5067 N N   . LEU B 1 332 ? 143.934 104.815 129.017 1.00 44.72  ? 363 LEU B N   1 
ATOM   5068 C CA  . LEU B 1 332 ? 142.633 104.910 129.665 1.00 47.11  ? 363 LEU B CA  1 
ATOM   5069 C C   . LEU B 1 332 ? 141.543 104.403 128.725 1.00 47.74  ? 363 LEU B C   1 
ATOM   5070 O O   . LEU B 1 332 ? 141.548 104.745 127.543 1.00 49.42  ? 363 LEU B O   1 
ATOM   5071 C CB  . LEU B 1 332 ? 142.328 106.344 130.072 1.00 44.95  ? 363 LEU B CB  1 
ATOM   5072 C CG  . LEU B 1 332 ? 142.916 106.818 131.393 1.00 47.44  ? 363 LEU B CG  1 
ATOM   5073 C CD1 . LEU B 1 332 ? 142.669 108.299 131.564 1.00 51.97  ? 363 LEU B CD1 1 
ATOM   5074 C CD2 . LEU B 1 332 ? 142.300 106.040 132.530 1.00 48.61  ? 363 LEU B CD2 1 
ATOM   5075 N N   . PRO B 1 333 ? 140.595 103.597 129.225 1.00 44.22  ? 364 PRO B N   1 
ATOM   5076 C CA  . PRO B 1 333 ? 139.577 103.023 128.333 1.00 39.09  ? 364 PRO B CA  1 
ATOM   5077 C C   . PRO B 1 333 ? 138.500 104.003 127.906 1.00 40.13  ? 364 PRO B C   1 
ATOM   5078 O O   . PRO B 1 333 ? 137.800 103.747 126.922 1.00 43.11  ? 364 PRO B O   1 
ATOM   5079 C CB  . PRO B 1 333 ? 138.994 101.883 129.177 1.00 40.66  ? 364 PRO B CB  1 
ATOM   5080 C CG  . PRO B 1 333 ? 140.004 101.635 130.239 1.00 44.10  ? 364 PRO B CG  1 
ATOM   5081 C CD  . PRO B 1 333 ? 140.519 102.984 130.556 1.00 45.36  ? 364 PRO B CD  1 
ATOM   5082 N N   . SER B 1 334 ? 138.325 105.108 128.626 1.00 40.39  ? 365 SER B N   1 
ATOM   5083 C CA  . SER B 1 334 ? 137.431 106.152 128.142 1.00 44.22  ? 365 SER B CA  1 
ATOM   5084 C C   . SER B 1 334 ? 138.096 106.965 127.045 1.00 45.84  ? 365 SER B C   1 
ATOM   5085 O O   . SER B 1 334 ? 137.443 107.389 126.087 1.00 50.44  ? 365 SER B O   1 
ATOM   5086 C CB  . SER B 1 334 ? 137.007 107.061 129.287 1.00 48.75  ? 365 SER B CB  1 
ATOM   5087 O OG  . SER B 1 334 ? 138.134 107.619 129.933 1.00 50.23  ? 365 SER B OG  1 
ATOM   5088 N N   . ARG B 1 335 ? 139.402 107.200 127.174 1.00 46.27  ? 366 ARG B N   1 
ATOM   5089 C CA  . ARG B 1 335 ? 140.107 108.004 126.184 1.00 44.19  ? 366 ARG B CA  1 
ATOM   5090 C C   . ARG B 1 335 ? 140.498 107.177 124.969 1.00 42.14  ? 366 ARG B C   1 
ATOM   5091 O O   . ARG B 1 335 ? 140.821 107.735 123.917 1.00 47.24  ? 366 ARG B O   1 
ATOM   5092 C CB  . ARG B 1 335 ? 141.337 108.651 126.814 1.00 44.92  ? 366 ARG B CB  1 
ATOM   5093 C CG  . ARG B 1 335 ? 141.026 109.527 128.002 1.00 48.24  ? 366 ARG B CG  1 
ATOM   5094 C CD  . ARG B 1 335 ? 140.950 110.979 127.585 1.00 53.38  ? 366 ARG B CD  1 
ATOM   5095 N NE  . ARG B 1 335 ? 140.841 111.874 128.729 1.00 56.08  ? 366 ARG B NE  1 
ATOM   5096 C CZ  . ARG B 1 335 ? 140.480 113.146 128.646 1.00 62.55  ? 366 ARG B CZ  1 
ATOM   5097 N NH1 . ARG B 1 335 ? 140.180 113.704 127.486 1.00 64.98  ? 366 ARG B NH1 1 
ATOM   5098 N NH2 . ARG B 1 335 ? 140.417 113.876 129.755 1.00 64.34  ? 366 ARG B NH2 1 
ATOM   5099 N N   . VAL B 1 336 ? 140.488 105.849 125.090 1.00 38.44  ? 367 VAL B N   1 
ATOM   5100 C CA  . VAL B 1 336 ? 140.695 105.014 123.912 1.00 35.94  ? 367 VAL B CA  1 
ATOM   5101 C C   . VAL B 1 336 ? 139.417 104.959 123.086 1.00 40.31  ? 367 VAL B C   1 
ATOM   5102 O O   . VAL B 1 336 ? 139.432 105.267 121.892 1.00 44.37  ? 367 VAL B O   1 
ATOM   5103 C CB  . VAL B 1 336 ? 141.202 103.613 124.316 1.00 36.13  ? 367 VAL B CB  1 
ATOM   5104 C CG1 . VAL B 1 336 ? 140.976 102.577 123.227 1.00 37.85  ? 367 VAL B CG1 1 
ATOM   5105 C CG2 . VAL B 1 336 ? 142.683 103.662 124.573 1.00 38.59  ? 367 VAL B CG2 1 
ATOM   5106 N N   . LEU B 1 337 ? 138.281 104.654 123.729 1.00 41.60  ? 368 LEU B N   1 
ATOM   5107 C CA  . LEU B 1 337 ? 137.059 104.315 122.999 1.00 40.03  ? 368 LEU B CA  1 
ATOM   5108 C C   . LEU B 1 337 ? 136.346 105.545 122.458 1.00 40.96  ? 368 LEU B C   1 
ATOM   5109 O O   . LEU B 1 337 ? 135.555 105.441 121.514 1.00 40.75  ? 368 LEU B O   1 
ATOM   5110 C CB  . LEU B 1 337 ? 136.106 103.543 123.896 1.00 39.75  ? 368 LEU B CB  1 
ATOM   5111 C CG  . LEU B 1 337 ? 136.434 102.113 124.273 1.00 41.91  ? 368 LEU B CG  1 
ATOM   5112 C CD1 . LEU B 1 337 ? 135.421 101.717 125.308 1.00 44.69  ? 368 LEU B CD1 1 
ATOM   5113 C CD2 . LEU B 1 337 ? 136.378 101.205 123.067 1.00 41.12  ? 368 LEU B CD2 1 
ATOM   5114 N N   . SER B 1 338 ? 136.583 106.710 123.057 1.00 40.43  ? 369 SER B N   1 
ATOM   5115 C CA  . SER B 1 338 ? 136.078 107.940 122.466 1.00 40.71  ? 369 SER B CA  1 
ATOM   5116 C C   . SER B 1 338 ? 136.913 108.325 121.257 1.00 41.59  ? 369 SER B C   1 
ATOM   5117 O O   . SER B 1 338 ? 136.393 108.839 120.264 1.00 46.24  ? 369 SER B O   1 
ATOM   5118 C CB  . SER B 1 338 ? 136.069 109.062 123.500 1.00 48.43  ? 369 SER B CB  1 
ATOM   5119 O OG  . SER B 1 338 ? 137.336 109.683 123.580 1.00 52.83  ? 369 SER B OG  1 
ATOM   5120 N N   . PHE B 1 339 ? 138.216 108.060 121.318 1.00 39.29  ? 370 PHE B N   1 
ATOM   5121 C CA  . PHE B 1 339 ? 139.079 108.365 120.186 1.00 40.34  ? 370 PHE B CA  1 
ATOM   5122 C C   . PHE B 1 339 ? 138.960 107.312 119.093 1.00 40.85  ? 370 PHE B C   1 
ATOM   5123 O O   . PHE B 1 339 ? 139.013 107.647 117.908 1.00 42.68  ? 370 PHE B O   1 
ATOM   5124 C CB  . PHE B 1 339 ? 140.523 108.509 120.655 1.00 40.02  ? 370 PHE B CB  1 
ATOM   5125 C CG  . PHE B 1 339 ? 141.491 108.826 119.559 1.00 39.04  ? 370 PHE B CG  1 
ATOM   5126 C CD1 . PHE B 1 339 ? 141.269 109.902 118.697 1.00 39.98  ? 370 PHE B CD1 1 
ATOM   5127 C CD2 . PHE B 1 339 ? 142.637 108.055 119.404 1.00 39.21  ? 370 PHE B CD2 1 
ATOM   5128 C CE1 . PHE B 1 339 ? 142.177 110.192 117.686 1.00 41.75  ? 370 PHE B CE1 1 
ATOM   5129 C CE2 . PHE B 1 339 ? 143.551 108.330 118.397 1.00 38.96  ? 370 PHE B CE2 1 
ATOM   5130 C CZ  . PHE B 1 339 ? 143.318 109.395 117.539 1.00 39.05  ? 370 PHE B CZ  1 
ATOM   5131 N N   . ALA B 1 340 ? 138.741 106.042 119.454 1.00 37.35  ? 371 ALA B N   1 
ATOM   5132 C CA  . ALA B 1 340 ? 138.671 104.997 118.432 1.00 34.10  ? 371 ALA B CA  1 
ATOM   5133 C C   . ALA B 1 340 ? 137.285 104.898 117.812 1.00 39.18  ? 371 ALA B C   1 
ATOM   5134 O O   . ALA B 1 340 ? 137.082 104.146 116.857 1.00 41.44  ? 371 ALA B O   1 
ATOM   5135 C CB  . ALA B 1 340 ? 139.077 103.642 119.002 1.00 32.60  ? 371 ALA B CB  1 
ATOM   5136 N N   . GLY B 1 341 ? 136.310 105.632 118.347 1.00 42.22  ? 372 GLY B N   1 
ATOM   5137 C CA  . GLY B 1 341 ? 135.040 105.756 117.655 1.00 45.83  ? 372 GLY B CA  1 
ATOM   5138 C C   . GLY B 1 341 ? 135.124 106.671 116.448 1.00 47.41  ? 372 GLY B C   1 
ATOM   5139 O O   . GLY B 1 341 ? 134.331 106.559 115.513 1.00 48.65  ? 372 GLY B O   1 
ATOM   5140 N N   . SER B 1 342 ? 136.090 107.595 116.453 1.00 44.15  ? 373 SER B N   1 
ATOM   5141 C CA  . SER B 1 342 ? 136.200 108.557 115.364 1.00 43.43  ? 373 SER B CA  1 
ATOM   5142 C C   . SER B 1 342 ? 137.225 108.126 114.324 1.00 43.05  ? 373 SER B C   1 
ATOM   5143 O O   . SER B 1 342 ? 137.156 108.558 113.169 1.00 48.55  ? 373 SER B O   1 
ATOM   5144 C CB  . SER B 1 342 ? 136.550 109.932 115.917 1.00 44.73  ? 373 SER B CB  1 
ATOM   5145 O OG  . SER B 1 342 ? 135.397 110.562 116.436 1.00 50.61  ? 373 SER B OG  1 
ATOM   5146 N N   . ILE B 1 343 ? 138.200 107.303 114.716 1.00 41.47  ? 374 ILE B N   1 
ATOM   5147 C CA  . ILE B 1 343 ? 139.216 106.834 113.775 1.00 42.61  ? 374 ILE B CA  1 
ATOM   5148 C C   . ILE B 1 343 ? 138.645 105.771 112.837 1.00 46.06  ? 374 ILE B C   1 
ATOM   5149 O O   . ILE B 1 343 ? 138.937 105.773 111.635 1.00 52.46  ? 374 ILE B O   1 
ATOM   5150 C CB  . ILE B 1 343 ? 140.465 106.366 114.554 1.00 40.19  ? 374 ILE B CB  1 
ATOM   5151 C CG1 . ILE B 1 343 ? 141.078 107.550 115.294 1.00 42.79  ? 374 ILE B CG1 1 
ATOM   5152 C CG2 . ILE B 1 343 ? 141.545 105.759 113.686 1.00 39.52  ? 374 ILE B CG2 1 
ATOM   5153 C CD1 . ILE B 1 343 ? 141.531 108.692 114.380 1.00 42.14  ? 374 ILE B CD1 1 
ATOM   5154 N N   . ILE B 1 344 ? 137.749 104.914 113.340 1.00 43.07  ? 375 ILE B N   1 
ATOM   5155 C CA  . ILE B 1 344 ? 137.100 103.909 112.493 1.00 44.14  ? 375 ILE B CA  1 
ATOM   5156 C C   . ILE B 1 344 ? 136.047 104.568 111.588 1.00 47.49  ? 375 ILE B C   1 
ATOM   5157 O O   . ILE B 1 344 ? 135.794 104.104 110.470 1.00 49.46  ? 375 ILE B O   1 
ATOM   5158 C CB  . ILE B 1 344 ? 136.546 102.779 113.398 1.00 46.80  ? 375 ILE B CB  1 
ATOM   5159 C CG1 . ILE B 1 344 ? 137.694 102.169 114.205 1.00 46.68  ? 375 ILE B CG1 1 
ATOM   5160 C CG2 . ILE B 1 344 ? 135.954 101.597 112.613 1.00 48.53  ? 375 ILE B CG2 1 
ATOM   5161 C CD1 . ILE B 1 344 ? 137.266 101.162 115.275 1.00 48.44  ? 375 ILE B CD1 1 
ATOM   5162 N N   . ASP B 1 345 ? 135.524 105.731 111.987 1.00 48.22  ? 376 ASP B N   1 
ATOM   5163 C CA  . ASP B 1 345 ? 134.757 106.560 111.055 1.00 48.16  ? 376 ASP B CA  1 
ATOM   5164 C C   . ASP B 1 345 ? 135.658 107.264 110.040 1.00 48.71  ? 376 ASP B C   1 
ATOM   5165 O O   . ASP B 1 345 ? 135.196 107.668 108.967 1.00 51.32  ? 376 ASP B O   1 
ATOM   5166 C CB  . ASP B 1 345 ? 133.930 107.586 111.824 1.00 47.86  ? 376 ASP B CB  1 
ATOM   5167 C CG  . ASP B 1 345 ? 132.862 106.947 112.668 1.00 49.45  ? 376 ASP B CG  1 
ATOM   5168 O OD1 . ASP B 1 345 ? 132.560 105.763 112.428 1.00 49.65  ? 376 ASP B OD1 1 
ATOM   5169 O OD2 . ASP B 1 345 ? 132.329 107.625 113.570 1.00 50.32  ? 376 ASP B OD2 1 
ATOM   5170 N N   . LEU B 1 346 ? 136.943 107.433 110.360 1.00 47.36  ? 377 LEU B N   1 
ATOM   5171 C CA  . LEU B 1 346 ? 137.843 108.139 109.454 1.00 43.55  ? 377 LEU B CA  1 
ATOM   5172 C C   . LEU B 1 346 ? 138.622 107.181 108.563 1.00 46.14  ? 377 LEU B C   1 
ATOM   5173 O O   . LEU B 1 346 ? 138.880 107.494 107.397 1.00 53.10  ? 377 LEU B O   1 
ATOM   5174 C CB  . LEU B 1 346 ? 138.797 109.022 110.251 1.00 46.08  ? 377 LEU B CB  1 
ATOM   5175 C CG  . LEU B 1 346 ? 139.696 110.029 109.533 1.00 53.46  ? 377 LEU B CG  1 
ATOM   5176 C CD1 . LEU B 1 346 ? 138.975 110.774 108.426 1.00 52.48  ? 377 LEU B CD1 1 
ATOM   5177 C CD2 . LEU B 1 346 ? 140.235 111.008 110.548 1.00 56.57  ? 377 LEU B CD2 1 
ATOM   5178 N N   . MET B 1 347 ? 139.026 106.018 109.083 1.00 45.65  ? 378 MET B N   1 
ATOM   5179 C CA  . MET B 1 347 ? 139.817 105.104 108.263 1.00 47.04  ? 378 MET B CA  1 
ATOM   5180 C C   . MET B 1 347 ? 138.937 104.261 107.346 1.00 52.61  ? 378 MET B C   1 
ATOM   5181 O O   . MET B 1 347 ? 139.441 103.636 106.407 1.00 55.44  ? 378 MET B O   1 
ATOM   5182 C CB  . MET B 1 347 ? 140.691 104.200 109.132 1.00 49.85  ? 378 MET B CB  1 
ATOM   5183 C CG  . MET B 1 347 ? 141.708 104.917 110.005 1.00 51.01  ? 378 MET B CG  1 
ATOM   5184 S SD  . MET B 1 347 ? 143.247 105.412 109.221 1.00 61.59  ? 378 MET B SD  1 
ATOM   5185 C CE  . MET B 1 347 ? 143.454 107.044 109.930 1.00 54.62  ? 378 MET B CE  1 
ATOM   5186 N N   . ASN B 1 348 ? 137.626 104.210 107.604 1.00 50.80  ? 379 ASN B N   1 
ATOM   5187 C CA  . ASN B 1 348 ? 136.722 103.594 106.637 1.00 49.82  ? 379 ASN B CA  1 
ATOM   5188 C C   . ASN B 1 348 ? 136.325 104.590 105.559 1.00 52.36  ? 379 ASN B C   1 
ATOM   5189 O O   . ASN B 1 348 ? 135.889 104.196 104.471 1.00 58.02  ? 379 ASN B O   1 
ATOM   5190 C CB  . ASN B 1 348 ? 135.481 103.040 107.325 1.00 48.77  ? 379 ASN B CB  1 
ATOM   5191 C CG  . ASN B 1 348 ? 135.752 101.744 108.043 1.00 54.34  ? 379 ASN B CG  1 
ATOM   5192 O OD1 . ASN B 1 348 ? 136.719 101.047 107.739 1.00 57.77  ? 379 ASN B OD1 1 
ATOM   5193 N ND2 . ASN B 1 348 ? 134.902 101.410 109.008 1.00 55.16  ? 379 ASN B ND2 1 
ATOM   5194 N N   . TRP B 1 349 ? 136.437 105.884 105.859 1.00 48.08  ? 380 TRP B N   1 
ATOM   5195 C CA  . TRP B 1 349 ? 136.367 106.894 104.811 1.00 50.32  ? 380 TRP B CA  1 
ATOM   5196 C C   . TRP B 1 349 ? 137.600 106.831 103.922 1.00 50.75  ? 380 TRP B C   1 
ATOM   5197 O O   . TRP B 1 349 ? 137.510 107.049 102.710 1.00 57.00  ? 380 TRP B O   1 
ATOM   5198 C CB  . TRP B 1 349 ? 136.215 108.284 105.433 1.00 49.94  ? 380 TRP B CB  1 
ATOM   5199 C CG  . TRP B 1 349 ? 136.245 109.420 104.447 1.00 52.42  ? 380 TRP B CG  1 
ATOM   5200 C CD1 . TRP B 1 349 ? 135.187 109.941 103.766 1.00 55.28  ? 380 TRP B CD1 1 
ATOM   5201 C CD2 . TRP B 1 349 ? 137.389 110.186 104.055 1.00 52.07  ? 380 TRP B CD2 1 
ATOM   5202 N NE1 . TRP B 1 349 ? 135.602 110.971 102.961 1.00 56.29  ? 380 TRP B NE1 1 
ATOM   5203 C CE2 . TRP B 1 349 ? 136.952 111.138 103.116 1.00 53.47  ? 380 TRP B CE2 1 
ATOM   5204 C CE3 . TRP B 1 349 ? 138.747 110.136 104.388 1.00 52.69  ? 380 TRP B CE3 1 
ATOM   5205 C CZ2 . TRP B 1 349 ? 137.823 112.047 102.517 1.00 52.12  ? 380 TRP B CZ2 1 
ATOM   5206 C CZ3 . TRP B 1 349 ? 139.611 111.041 103.794 1.00 57.00  ? 380 TRP B CZ3 1 
ATOM   5207 C CH2 . TRP B 1 349 ? 139.144 111.986 102.870 1.00 53.09  ? 380 TRP B CH2 1 
ATOM   5208 N N   . LEU B 1 350 ? 138.761 106.540 104.515 1.00 47.39  ? 381 LEU B N   1 
ATOM   5209 C CA  . LEU B 1 350 ? 140.028 106.602 103.794 1.00 48.05  ? 381 LEU B CA  1 
ATOM   5210 C C   . LEU B 1 350 ? 140.203 105.411 102.864 1.00 50.20  ? 381 LEU B C   1 
ATOM   5211 O O   . LEU B 1 350 ? 140.965 105.484 101.898 1.00 60.05  ? 381 LEU B O   1 
ATOM   5212 C CB  . LEU B 1 350 ? 141.186 106.679 104.790 1.00 50.26  ? 381 LEU B CB  1 
ATOM   5213 C CG  . LEU B 1 350 ? 142.570 107.162 104.348 1.00 46.05  ? 381 LEU B CG  1 
ATOM   5214 C CD1 . LEU B 1 350 ? 142.474 108.421 103.497 1.00 41.34  ? 381 LEU B CD1 1 
ATOM   5215 C CD2 . LEU B 1 350 ? 143.463 107.382 105.554 1.00 50.01  ? 381 LEU B CD2 1 
ATOM   5216 N N   . ARG B 1 351 ? 139.507 104.312 103.132 1.00 46.08  ? 382 ARG B N   1 
ATOM   5217 C CA  . ARG B 1 351 ? 139.564 103.166 102.234 1.00 52.10  ? 382 ARG B CA  1 
ATOM   5218 C C   . ARG B 1 351 ? 138.753 103.427 100.973 1.00 57.74  ? 382 ARG B C   1 
ATOM   5219 O O   . ARG B 1 351 ? 139.091 102.939 99.890  1.00 65.11  ? 382 ARG B O   1 
ATOM   5220 C CB  . ARG B 1 351 ? 139.059 101.927 102.963 1.00 56.68  ? 382 ARG B CB  1 
ATOM   5221 C CG  . ARG B 1 351 ? 139.453 100.592 102.365 1.00 56.53  ? 382 ARG B CG  1 
ATOM   5222 C CD  . ARG B 1 351 ? 138.464 99.503  102.774 1.00 55.04  ? 382 ARG B CD  1 
ATOM   5223 N NE  . ARG B 1 351 ? 138.579 99.114  104.176 1.00 57.08  ? 382 ARG B NE  1 
ATOM   5224 C CZ  . ARG B 1 351 ? 137.719 99.454  105.127 1.00 54.50  ? 382 ARG B CZ  1 
ATOM   5225 N NH1 . ARG B 1 351 ? 136.682 100.234 104.873 1.00 49.97  ? 382 ARG B NH1 1 
ATOM   5226 N NH2 . ARG B 1 351 ? 137.917 99.019  106.368 1.00 57.55  ? 382 ARG B NH2 1 
ATOM   5227 N N   . GLY B 1 352 ? 137.678 104.204 101.098 1.00 56.59  ? 383 GLY B N   1 
ATOM   5228 C CA  . GLY B 1 352 ? 136.931 104.604 99.918  1.00 60.35  ? 383 GLY B CA  1 
ATOM   5229 C C   . GLY B 1 352 ? 137.617 105.719 99.155  1.00 58.50  ? 383 GLY B C   1 
ATOM   5230 O O   . GLY B 1 352 ? 137.501 105.809 97.930  1.00 60.65  ? 383 GLY B O   1 
ATOM   5231 N N   . SER B 1 353 ? 138.359 106.573 99.865  1.00 56.53  ? 384 SER B N   1 
ATOM   5232 C CA  . SER B 1 353 ? 139.039 107.689 99.216  1.00 54.98  ? 384 SER B CA  1 
ATOM   5233 C C   . SER B 1 353 ? 140.341 107.242 98.565  1.00 58.41  ? 384 SER B C   1 
ATOM   5234 O O   . SER B 1 353 ? 140.913 107.968 97.745  1.00 59.65  ? 384 SER B O   1 
ATOM   5235 C CB  . SER B 1 353 ? 139.298 108.803 100.228 1.00 50.56  ? 384 SER B CB  1 
ATOM   5236 O OG  . SER B 1 353 ? 139.596 110.017 99.575  1.00 48.74  ? 384 SER B OG  1 
ATOM   5237 N N   . LEU B 1 354 ? 140.842 106.063 98.938  1.00 59.70  ? 385 LEU B N   1 
ATOM   5238 C CA  . LEU B 1 354 ? 141.964 105.478 98.216  1.00 61.77  ? 385 LEU B CA  1 
ATOM   5239 C C   . LEU B 1 354 ? 141.484 104.483 97.169  1.00 64.52  ? 385 LEU B C   1 
ATOM   5240 O O   . LEU B 1 354 ? 142.288 103.935 96.412  1.00 69.19  ? 385 LEU B O   1 
ATOM   5241 C CB  . LEU B 1 354 ? 142.926 104.799 99.188  1.00 63.75  ? 385 LEU B CB  1 
ATOM   5242 C CG  . LEU B 1 354 ? 143.793 105.673 100.091 1.00 63.69  ? 385 LEU B CG  1 
ATOM   5243 C CD1 . LEU B 1 354 ? 144.357 104.824 101.212 1.00 59.71  ? 385 LEU B CD1 1 
ATOM   5244 C CD2 . LEU B 1 354 ? 144.894 106.329 99.314  1.00 66.60  ? 385 LEU B CD2 1 
ATOM   5245 N N   . SER B 1 355 ? 140.178 104.218 97.121  1.00 62.15  ? 386 SER B N   1 
ATOM   5246 C CA  . SER B 1 355 ? 139.663 103.291 96.119  1.00 61.64  ? 386 SER B CA  1 
ATOM   5247 C C   . SER B 1 355 ? 139.440 103.996 94.788  1.00 59.48  ? 386 SER B C   1 
ATOM   5248 O O   . SER B 1 355 ? 139.806 103.479 93.727  1.00 56.40  ? 386 SER B O   1 
ATOM   5249 C CB  . SER B 1 355 ? 138.368 102.648 96.612  1.00 63.61  ? 386 SER B CB  1 
ATOM   5250 O OG  . SER B 1 355 ? 137.853 101.739 95.655  1.00 72.34  ? 386 SER B OG  1 
ATOM   5251 N N   . LYS B 1 356 ? 138.842 105.185 94.830  1.00 60.78  ? 387 LYS B N   1 
ATOM   5252 C CA  . LYS B 1 356 ? 138.509 105.889 93.597  1.00 66.17  ? 387 LYS B CA  1 
ATOM   5253 C C   . LYS B 1 356 ? 139.690 106.703 93.076  1.00 68.31  ? 387 LYS B C   1 
ATOM   5254 O O   . LYS B 1 356 ? 139.751 107.017 91.882  1.00 68.22  ? 387 LYS B O   1 
ATOM   5255 C CB  . LYS B 1 356 ? 137.291 106.784 93.823  1.00 65.35  ? 387 LYS B CB  1 
ATOM   5256 C CG  . LYS B 1 356 ? 137.375 107.642 95.074  1.00 62.28  ? 387 LYS B CG  1 
ATOM   5257 C CD  . LYS B 1 356 ? 136.035 108.273 95.416  1.00 63.23  ? 387 LYS B CD  1 
ATOM   5258 C CE  . LYS B 1 356 ? 136.125 109.078 96.701  1.00 64.20  ? 387 LYS B CE  1 
ATOM   5259 N NZ  . LYS B 1 356 ? 134.787 109.471 97.214  1.00 67.05  ? 387 LYS B NZ  1 
ATOM   5260 N N   . HIS B 1 357 ? 140.635 107.056 93.950  1.00 66.61  ? 388 HIS B N   1 
ATOM   5261 C CA  . HIS B 1 357 ? 141.749 107.922 93.588  1.00 63.50  ? 388 HIS B CA  1 
ATOM   5262 C C   . HIS B 1 357 ? 143.048 107.161 93.361  1.00 61.80  ? 388 HIS B C   1 
ATOM   5263 O O   . HIS B 1 357 ? 143.963 107.691 92.726  1.00 62.07  ? 388 HIS B O   1 
ATOM   5264 C CB  . HIS B 1 357 ? 141.968 108.984 94.664  1.00 60.46  ? 388 HIS B CB  1 
ATOM   5265 C CG  . HIS B 1 357 ? 140.841 109.952 94.798  1.00 57.86  ? 388 HIS B CG  1 
ATOM   5266 N ND1 . HIS B 1 357 ? 140.123 110.098 95.965  1.00 58.94  ? 388 HIS B ND1 1 
ATOM   5267 C CD2 . HIS B 1 357 ? 140.306 110.826 93.915  1.00 58.56  ? 388 HIS B CD2 1 
ATOM   5268 C CE1 . HIS B 1 357 ? 139.194 111.020 95.795  1.00 58.49  ? 388 HIS B CE1 1 
ATOM   5269 N NE2 . HIS B 1 357 ? 139.283 111.477 94.559  1.00 60.51  ? 388 HIS B NE2 1 
ATOM   5270 N N   . CYS B 1 358 ? 143.147 105.929 93.843  1.00 61.69  ? 389 CYS B N   1 
ATOM   5271 C CA  . CYS B 1 358 ? 144.428 105.242 93.828  1.00 62.52  ? 389 CYS B CA  1 
ATOM   5272 C C   . CYS B 1 358 ? 144.221 103.805 93.374  1.00 66.77  ? 389 CYS B C   1 
ATOM   5273 O O   . CYS B 1 358 ? 143.152 103.219 93.553  1.00 70.37  ? 389 CYS B O   1 
ATOM   5274 C CB  . CYS B 1 358 ? 145.087 105.293 95.205  1.00 67.32  ? 389 CYS B CB  1 
ATOM   5275 S SG  . CYS B 1 358 ? 146.688 104.468 95.311  1.00 89.37  ? 389 CYS B SG  1 
ATOM   5276 N N   . LYS B 1 359 ? 145.273 103.238 92.800  1.00 66.35  ? 390 LYS B N   1 
ATOM   5277 C CA  . LYS B 1 359 ? 145.243 101.896 92.243  1.00 63.71  ? 390 LYS B CA  1 
ATOM   5278 C C   . LYS B 1 359 ? 145.932 100.945 93.207  1.00 70.82  ? 390 LYS B C   1 
ATOM   5279 O O   . LYS B 1 359 ? 146.791 101.363 93.989  1.00 73.11  ? 390 LYS B O   1 
ATOM   5280 C CB  . LYS B 1 359 ? 145.927 101.857 90.879  1.00 61.88  ? 390 LYS B CB  1 
ATOM   5281 C CG  . LYS B 1 359 ? 145.452 102.937 89.938  1.00 64.12  ? 390 LYS B CG  1 
ATOM   5282 C CD  . LYS B 1 359 ? 146.474 103.213 88.856  1.00 68.40  ? 390 LYS B CD  1 
ATOM   5283 C CE  . LYS B 1 359 ? 146.134 104.490 88.106  1.00 70.42  ? 390 LYS B CE  1 
ATOM   5284 N NZ  . LYS B 1 359 ? 147.224 104.898 87.177  1.00 71.73  ? 390 LYS B NZ  1 
ATOM   5285 N N   . ARG B 1 360 ? 145.552 99.675  93.151  1.00 78.12  ? 391 ARG B N   1 
ATOM   5286 C CA  . ARG B 1 360 ? 146.100 98.669  94.050  1.00 78.78  ? 391 ARG B CA  1 
ATOM   5287 C C   . ARG B 1 360 ? 147.369 98.057  93.471  1.00 72.84  ? 391 ARG B C   1 
ATOM   5288 O O   . ARG B 1 360 ? 147.459 97.817  92.267  1.00 67.91  ? 391 ARG B O   1 
ATOM   5289 C CB  . ARG B 1 360 ? 145.062 97.580  94.322  1.00 79.65  ? 391 ARG B CB  1 
ATOM   5290 C CG  . ARG B 1 360 ? 143.691 98.107  94.701  1.00 81.06  ? 391 ARG B CG  1 
ATOM   5291 C CD  . ARG B 1 360 ? 142.765 96.991  95.143  1.00 91.60  ? 391 ARG B CD  1 
ATOM   5292 N NE  . ARG B 1 360 ? 141.394 97.452  95.325  1.00 103.29 ? 391 ARG B NE  1 
ATOM   5293 C CZ  . ARG B 1 360 ? 140.376 96.664  95.646  1.00 107.78 ? 391 ARG B CZ  1 
ATOM   5294 N NH1 . ARG B 1 360 ? 140.539 95.364  95.826  1.00 107.12 ? 391 ARG B NH1 1 
ATOM   5295 N NH2 . ARG B 1 360 ? 139.164 97.194  95.790  1.00 105.80 ? 391 ARG B NH2 1 
ATOM   5296 N N   . ASP B 1 365 ? 146.634 93.430  96.087  1.00 85.94  ? 396 ASP B N   1 
ATOM   5297 C CA  . ASP B 1 365 ? 145.484 94.320  96.206  1.00 86.81  ? 396 ASP B CA  1 
ATOM   5298 C C   . ASP B 1 365 ? 145.744 95.426  97.223  1.00 82.48  ? 396 ASP B C   1 
ATOM   5299 O O   . ASP B 1 365 ? 144.817 95.936  97.849  1.00 82.32  ? 396 ASP B O   1 
ATOM   5300 C CB  . ASP B 1 365 ? 144.234 93.528  96.595  1.00 87.62  ? 396 ASP B CB  1 
ATOM   5301 C CG  . ASP B 1 365 ? 143.655 92.748  95.432  1.00 86.57  ? 396 ASP B CG  1 
ATOM   5302 O OD1 . ASP B 1 365 ? 144.222 92.827  94.322  1.00 83.06  ? 396 ASP B OD1 1 
ATOM   5303 O OD2 . ASP B 1 365 ? 142.633 92.059  95.630  1.00 85.79  ? 396 ASP B OD2 1 
ATOM   5304 N N   . LEU B 1 366 ? 147.011 95.803  97.361  1.00 76.77  ? 397 LEU B N   1 
ATOM   5305 C CA  . LEU B 1 366 ? 147.482 96.663  98.440  1.00 71.92  ? 397 LEU B CA  1 
ATOM   5306 C C   . LEU B 1 366 ? 147.712 98.061  97.873  1.00 71.60  ? 397 LEU B C   1 
ATOM   5307 O O   . LEU B 1 366 ? 148.385 98.208  96.847  1.00 73.07  ? 397 LEU B O   1 
ATOM   5308 C CB  . LEU B 1 366 ? 148.761 96.072  99.035  1.00 72.48  ? 397 LEU B CB  1 
ATOM   5309 C CG  . LEU B 1 366 ? 149.513 96.642  100.228 1.00 69.25  ? 397 LEU B CG  1 
ATOM   5310 C CD1 . LEU B 1 366 ? 148.602 96.574  101.423 1.00 65.77  ? 397 LEU B CD1 1 
ATOM   5311 C CD2 . LEU B 1 366 ? 150.786 95.838  100.481 1.00 63.67  ? 397 LEU B CD2 1 
ATOM   5312 N N   . TYR B 1 367 ? 147.146 99.078  98.529  1.00 69.59  ? 398 TYR B N   1 
ATOM   5313 C CA  . TYR B 1 367 ? 147.171 100.432 97.981  1.00 67.76  ? 398 TYR B CA  1 
ATOM   5314 C C   . TYR B 1 367 ? 148.527 101.090 98.196  1.00 69.60  ? 398 TYR B C   1 
ATOM   5315 O O   . TYR B 1 367 ? 148.762 101.735 99.220  1.00 70.42  ? 398 TYR B O   1 
ATOM   5316 C CB  . TYR B 1 367 ? 146.094 101.307 98.629  1.00 65.81  ? 398 TYR B CB  1 
ATOM   5317 C CG  . TYR B 1 367 ? 144.667 100.866 98.409  1.00 67.68  ? 398 TYR B CG  1 
ATOM   5318 C CD1 . TYR B 1 367 ? 143.982 100.157 99.397  1.00 69.33  ? 398 TYR B CD1 1 
ATOM   5319 C CD2 . TYR B 1 367 ? 143.998 101.165 97.216  1.00 65.47  ? 398 TYR B CD2 1 
ATOM   5320 C CE1 . TYR B 1 367 ? 142.660 99.752  99.207  1.00 68.55  ? 398 TYR B CE1 1 
ATOM   5321 C CE2 . TYR B 1 367 ? 142.675 100.759 97.013  1.00 62.12  ? 398 TYR B CE2 1 
ATOM   5322 C CZ  . TYR B 1 367 ? 142.021 100.056 98.014  1.00 65.99  ? 398 TYR B CZ  1 
ATOM   5323 O OH  . TYR B 1 367 ? 140.720 99.653  97.825  1.00 71.81  ? 398 TYR B OH  1 
ATOM   5324 N N   . VAL B 1 368 ? 149.407 100.955 97.204  1.00 69.59  ? 399 VAL B N   1 
ATOM   5325 C CA  . VAL B 1 368 ? 150.774 101.462 97.265  1.00 67.87  ? 399 VAL B CA  1 
ATOM   5326 C C   . VAL B 1 368 ? 150.733 102.967 97.042  1.00 72.60  ? 399 VAL B C   1 
ATOM   5327 O O   . VAL B 1 368 ? 150.129 103.432 96.070  1.00 75.67  ? 399 VAL B O   1 
ATOM   5328 C CB  . VAL B 1 368 ? 151.678 100.771 96.217  1.00 67.47  ? 399 VAL B CB  1 
ATOM   5329 C CG1 . VAL B 1 368 ? 153.122 101.247 96.312  1.00 68.46  ? 399 VAL B CG1 1 
ATOM   5330 C CG2 . VAL B 1 368 ? 151.613 99.262  96.367  1.00 72.53  ? 399 VAL B CG2 1 
ATOM   5331 N N   . LEU B 1 369 ? 151.393 103.725 97.938  1.00 70.91  ? 400 LEU B N   1 
ATOM   5332 C CA  . LEU B 1 369 ? 151.416 105.192 97.910  1.00 65.55  ? 400 LEU B CA  1 
ATOM   5333 C C   . LEU B 1 369 ? 152.155 105.769 96.704  1.00 66.57  ? 400 LEU B C   1 
ATOM   5334 O O   . LEU B 1 369 ? 151.884 106.910 96.317  1.00 68.59  ? 400 LEU B O   1 
ATOM   5335 C CB  . LEU B 1 369 ? 152.051 105.722 99.204  1.00 65.09  ? 400 LEU B CB  1 
ATOM   5336 C CG  . LEU B 1 369 ? 151.820 107.170 99.666  1.00 63.76  ? 400 LEU B CG  1 
ATOM   5337 C CD1 . LEU B 1 369 ? 150.392 107.414 100.094 1.00 63.52  ? 400 LEU B CD1 1 
ATOM   5338 C CD2 . LEU B 1 369 ? 152.777 107.542 100.784 1.00 59.45  ? 400 LEU B CD2 1 
ATOM   5339 N N   . GLU B 1 370 ? 153.049 105.001 96.075  1.00 68.58  ? 401 GLU B N   1 
ATOM   5340 C CA  . GLU B 1 370 ? 153.693 105.459 94.847  1.00 71.86  ? 401 GLU B CA  1 
ATOM   5341 C C   . GLU B 1 370 ? 152.742 105.411 93.653  1.00 70.53  ? 401 GLU B C   1 
ATOM   5342 O O   . GLU B 1 370 ? 152.957 106.110 92.656  1.00 71.92  ? 401 GLU B O   1 
ATOM   5343 C CB  . GLU B 1 370 ? 154.947 104.632 94.574  1.00 76.65  ? 401 GLU B CB  1 
ATOM   5344 C CG  . GLU B 1 370 ? 155.914 104.582 95.747  1.00 80.63  ? 401 GLU B CG  1 
ATOM   5345 C CD  . GLU B 1 370 ? 156.943 103.480 95.609  1.00 86.64  ? 401 GLU B CD  1 
ATOM   5346 O OE1 . GLU B 1 370 ? 156.839 102.683 94.653  1.00 91.81  ? 401 GLU B OE1 1 
ATOM   5347 O OE2 . GLU B 1 370 ? 157.857 103.412 96.457  1.00 85.10  ? 401 GLU B OE2 1 
ATOM   5348 N N   . SER B 1 371 ? 151.691 104.594 93.728  1.00 70.99  ? 402 SER B N   1 
ATOM   5349 C CA  . SER B 1 371 ? 150.628 104.595 92.733  1.00 70.51  ? 402 SER B CA  1 
ATOM   5350 C C   . SER B 1 371 ? 149.410 105.398 93.181  1.00 67.76  ? 402 SER B C   1 
ATOM   5351 O O   . SER B 1 371 ? 148.377 105.366 92.508  1.00 68.15  ? 402 SER B O   1 
ATOM   5352 C CB  . SER B 1 371 ? 150.219 103.162 92.394  1.00 73.77  ? 402 SER B CB  1 
ATOM   5353 O OG  . SER B 1 371 ? 149.375 103.129 91.258  1.00 78.50  ? 402 SER B OG  1 
ATOM   5354 N N   . CYS B 1 372 ? 149.505 106.113 94.299  1.00 70.50  ? 403 CYS B N   1 
ATOM   5355 C CA  . CYS B 1 372 ? 148.427 106.968 94.783  1.00 69.05  ? 403 CYS B CA  1 
ATOM   5356 C C   . CYS B 1 372 ? 148.694 108.409 94.378  1.00 75.36  ? 403 CYS B C   1 
ATOM   5357 O O   . CYS B 1 372 ? 149.800 108.921 94.580  1.00 81.14  ? 403 CYS B O   1 
ATOM   5358 C CB  . CYS B 1 372 ? 148.265 106.874 96.299  1.00 68.89  ? 403 CYS B CB  1 
ATOM   5359 S SG  . CYS B 1 372 ? 147.572 105.332 96.920  1.00 77.19  ? 403 CYS B SG  1 
ATOM   5360 N N   . PHE B 1 373 ? 147.682 109.056 93.810  1.00 70.90  ? 404 PHE B N   1 
ATOM   5361 C CA  . PHE B 1 373 ? 147.781 110.441 93.382  1.00 69.80  ? 404 PHE B CA  1 
ATOM   5362 C C   . PHE B 1 373 ? 146.508 111.174 93.764  1.00 68.82  ? 404 PHE B C   1 
ATOM   5363 O O   . PHE B 1 373 ? 145.409 110.665 93.518  1.00 72.18  ? 404 PHE B O   1 
ATOM   5364 C CB  . PHE B 1 373 ? 148.013 110.539 91.872  1.00 66.14  ? 404 PHE B CB  1 
ATOM   5365 N N   . ASN B 1 374 ? 146.686 112.354 94.378  1.00 69.62  ? 405 ASN B N   1 
ATOM   5366 C CA  . ASN B 1 374 ? 145.664 113.374 94.655  1.00 70.76  ? 405 ASN B CA  1 
ATOM   5367 C C   . ASN B 1 374 ? 144.531 112.881 95.548  1.00 66.45  ? 405 ASN B C   1 
ATOM   5368 O O   . ASN B 1 374 ? 143.384 113.282 95.374  1.00 71.33  ? 405 ASN B O   1 
ATOM   5369 C CB  . ASN B 1 374 ? 145.092 113.971 93.362  1.00 76.06  ? 405 ASN B CB  1 
ATOM   5370 C CG  . ASN B 1 374 ? 145.832 115.216 92.916  1.00 82.20  ? 405 ASN B CG  1 
ATOM   5371 O OD1 . ASN B 1 374 ? 146.669 115.750 93.642  1.00 87.50  ? 405 ASN B OD1 1 
ATOM   5372 N ND2 . ASN B 1 374 ? 145.524 115.687 91.714  1.00 80.44  ? 405 ASN B ND2 1 
ATOM   5373 N N   . PHE B 1 375 ? 144.833 112.015 96.510  1.00 63.42  ? 406 PHE B N   1 
ATOM   5374 C CA  . PHE B 1 375 ? 143.835 111.646 97.502  1.00 67.87  ? 406 PHE B CA  1 
ATOM   5375 C C   . PHE B 1 375 ? 143.825 112.667 98.638  1.00 68.96  ? 406 PHE B C   1 
ATOM   5376 O O   . PHE B 1 375 ? 144.608 113.625 98.639  1.00 75.69  ? 406 PHE B O   1 
ATOM   5377 C CB  . PHE B 1 375 ? 144.056 110.208 97.999  1.00 70.35  ? 406 PHE B CB  1 
ATOM   5378 C CG  . PHE B 1 375 ? 145.233 110.020 98.931  1.00 70.59  ? 406 PHE B CG  1 
ATOM   5379 C CD1 . PHE B 1 375 ? 146.533 109.918 98.426  1.00 69.05  ? 406 PHE B CD1 1 
ATOM   5380 C CD2 . PHE B 1 375 ? 145.031 109.880 100.308 1.00 71.47  ? 406 PHE B CD2 1 
ATOM   5381 C CE1 . PHE B 1 375 ? 147.614 109.724 99.276  1.00 69.45  ? 406 PHE B CE1 1 
ATOM   5382 C CE2 . PHE B 1 375 ? 146.107 109.690 101.171 1.00 71.42  ? 406 PHE B CE2 1 
ATOM   5383 C CZ  . PHE B 1 375 ? 147.399 109.610 100.649 1.00 70.23  ? 406 PHE B CZ  1 
ATOM   5384 N N   . LEU B 1 376 ? 142.934 112.413 99.617  1.00 63.91  ? 407 LEU B N   1 
ATOM   5385 C CA  . LEU B 1 376 ? 142.488 113.348 100.669 1.00 70.50  ? 407 LEU B CA  1 
ATOM   5386 C C   . LEU B 1 376 ? 142.033 114.687 100.092 1.00 78.82  ? 407 LEU B C   1 
ATOM   5387 O O   . LEU B 1 376 ? 142.543 115.742 100.476 1.00 81.53  ? 407 LEU B O   1 
ATOM   5388 C CB  . LEU B 1 376 ? 143.552 113.581 101.755 1.00 77.44  ? 407 LEU B CB  1 
ATOM   5389 C CG  . LEU B 1 376 ? 144.026 112.498 102.721 1.00 76.44  ? 407 LEU B CG  1 
ATOM   5390 C CD1 . LEU B 1 376 ? 145.400 112.864 103.244 1.00 64.53  ? 407 LEU B CD1 1 
ATOM   5391 C CD2 . LEU B 1 376 ? 143.058 112.351 103.874 1.00 76.69  ? 407 LEU B CD2 1 
ATOM   5392 N N   . ASN B 1 377 ? 141.096 114.664 99.145  1.00 81.80  ? 408 ASN B N   1 
ATOM   5393 C CA  . ASN B 1 377 ? 140.651 115.905 98.519  1.00 84.09  ? 408 ASN B CA  1 
ATOM   5394 C C   . ASN B 1 377 ? 139.608 116.632 99.356  1.00 85.42  ? 408 ASN B C   1 
ATOM   5395 O O   . ASN B 1 377 ? 139.804 117.794 99.724  1.00 84.61  ? 408 ASN B O   1 
ATOM   5396 C CB  . ASN B 1 377 ? 140.093 115.634 97.120  1.00 82.21  ? 408 ASN B CB  1 
ATOM   5397 C CG  . ASN B 1 377 ? 141.178 115.455 96.089  1.00 79.40  ? 408 ASN B CG  1 
ATOM   5398 O OD1 . ASN B 1 377 ? 142.193 116.147 96.116  1.00 76.24  ? 408 ASN B OD1 1 
ATOM   5399 N ND2 . ASN B 1 377 ? 140.965 114.536 95.159  1.00 79.82  ? 408 ASN B ND2 1 
ATOM   5400 N N   . PHE B 1 378 ? 138.501 115.967 99.666  1.00 84.48  ? 409 PHE B N   1 
ATOM   5401 C CA  . PHE B 1 378 ? 137.400 116.581 100.399 1.00 87.02  ? 409 PHE B CA  1 
ATOM   5402 C C   . PHE B 1 378 ? 137.404 115.959 101.788 1.00 84.62  ? 409 PHE B C   1 
ATOM   5403 O O   . PHE B 1 378 ? 136.639 115.035 102.066 1.00 85.95  ? 409 PHE B O   1 
ATOM   5404 C CB  . PHE B 1 378 ? 136.078 116.361 99.675  1.00 89.08  ? 409 PHE B CB  1 
ATOM   5405 C CG  . PHE B 1 378 ? 135.852 117.302 98.528  1.00 92.41  ? 409 PHE B CG  1 
ATOM   5406 C CD1 . PHE B 1 378 ? 135.400 118.604 98.758  1.00 93.11  ? 409 PHE B CD1 1 
ATOM   5407 C CD2 . PHE B 1 378 ? 136.103 116.887 97.218  1.00 91.80  ? 409 PHE B CD2 1 
ATOM   5408 C CE1 . PHE B 1 378 ? 135.195 119.485 97.694  1.00 93.01  ? 409 PHE B CE1 1 
ATOM   5409 C CE2 . PHE B 1 378 ? 135.903 117.757 96.144  1.00 92.18  ? 409 PHE B CE2 1 
ATOM   5410 C CZ  . PHE B 1 378 ? 135.448 119.057 96.386  1.00 92.14  ? 409 PHE B CZ  1 
ATOM   5411 N N   . ILE B 1 379 ? 138.239 116.510 102.670 1.00 83.75  ? 410 ILE B N   1 
ATOM   5412 C CA  . ILE B 1 379 ? 138.525 115.878 103.955 1.00 83.86  ? 410 ILE B CA  1 
ATOM   5413 C C   . ILE B 1 379 ? 137.410 116.143 104.967 1.00 82.13  ? 410 ILE B C   1 
ATOM   5414 O O   . ILE B 1 379 ? 137.276 115.399 105.947 1.00 84.16  ? 410 ILE B O   1 
ATOM   5415 C CB  . ILE B 1 379 ? 139.901 116.358 104.469 1.00 83.65  ? 410 ILE B CB  1 
ATOM   5416 C CG1 . ILE B 1 379 ? 140.889 116.472 103.309 1.00 85.36  ? 410 ILE B CG1 1 
ATOM   5417 C CG2 . ILE B 1 379 ? 140.556 115.330 105.391 1.00 74.56  ? 410 ILE B CG2 1 
ATOM   5418 C CD1 . ILE B 1 379 ? 142.169 117.216 103.636 1.00 79.17  ? 410 ILE B CD1 1 
ATOM   5419 N N   . GLU B 1 380 ? 136.550 117.132 104.719 1.00 81.75  ? 411 GLU B N   1 
ATOM   5420 C CA  . GLU B 1 380 ? 135.468 117.428 105.650 1.00 83.59  ? 411 GLU B CA  1 
ATOM   5421 C C   . GLU B 1 380 ? 134.238 116.548 105.444 1.00 86.49  ? 411 GLU B C   1 
ATOM   5422 O O   . GLU B 1 380 ? 133.265 116.694 106.189 1.00 89.10  ? 411 GLU B O   1 
ATOM   5423 C CB  . GLU B 1 380 ? 135.061 118.897 105.531 1.00 87.92  ? 411 GLU B CB  1 
ATOM   5424 C CG  . GLU B 1 380 ? 136.128 119.902 105.941 1.00 87.59  ? 411 GLU B CG  1 
ATOM   5425 C CD  . GLU B 1 380 ? 136.399 119.905 107.433 1.00 91.50  ? 411 GLU B CD  1 
ATOM   5426 O OE1 . GLU B 1 380 ? 135.449 119.691 108.214 1.00 92.01  ? 411 GLU B OE1 1 
ATOM   5427 O OE2 . GLU B 1 380 ? 137.561 120.138 107.826 1.00 89.79  ? 411 GLU B OE2 1 
ATOM   5428 N N   . ASP B 1 381 ? 134.250 115.640 104.461 1.00 88.59  ? 412 ASP B N   1 
ATOM   5429 C CA  . ASP B 1 381 ? 133.074 114.831 104.151 1.00 90.93  ? 412 ASP B CA  1 
ATOM   5430 C C   . ASP B 1 381 ? 132.843 113.674 105.116 1.00 88.34  ? 412 ASP B C   1 
ATOM   5431 O O   . ASP B 1 381 ? 131.790 113.035 105.025 1.00 86.72  ? 412 ASP B O   1 
ATOM   5432 C CB  . ASP B 1 381 ? 133.156 114.265 102.732 1.00 91.29  ? 412 ASP B CB  1 
ATOM   5433 C CG  . ASP B 1 381 ? 133.157 115.339 101.669 1.00 94.27  ? 412 ASP B CG  1 
ATOM   5434 O OD1 . ASP B 1 381 ? 133.157 116.538 102.021 1.00 93.13  ? 412 ASP B OD1 1 
ATOM   5435 O OD2 . ASP B 1 381 ? 133.122 114.978 100.474 1.00 97.03  ? 412 ASP B OD2 1 
ATOM   5436 N N   . TRP B 1 382 ? 133.780 113.371 106.020 1.00 83.70  ? 413 TRP B N   1 
ATOM   5437 C CA  . TRP B 1 382 ? 133.533 112.285 106.964 1.00 80.67  ? 413 TRP B CA  1 
ATOM   5438 C C   . TRP B 1 382 ? 132.759 112.780 108.181 1.00 83.62  ? 413 TRP B C   1 
ATOM   5439 O O   . TRP B 1 382 ? 132.278 111.976 108.985 1.00 84.58  ? 413 TRP B O   1 
ATOM   5440 C CB  . TRP B 1 382 ? 134.847 111.618 107.379 1.00 76.82  ? 413 TRP B CB  1 
ATOM   5441 C CG  . TRP B 1 382 ? 135.625 112.338 108.433 1.00 78.67  ? 413 TRP B CG  1 
ATOM   5442 C CD1 . TRP B 1 382 ? 136.474 113.377 108.250 1.00 78.94  ? 413 TRP B CD1 1 
ATOM   5443 C CD2 . TRP B 1 382 ? 135.661 112.033 109.835 1.00 80.76  ? 413 TRP B CD2 1 
ATOM   5444 N NE1 . TRP B 1 382 ? 137.021 113.762 109.446 1.00 76.72  ? 413 TRP B NE1 1 
ATOM   5445 C CE2 . TRP B 1 382 ? 136.539 112.952 110.437 1.00 76.84  ? 413 TRP B CE2 1 
ATOM   5446 C CE3 . TRP B 1 382 ? 135.024 111.080 110.640 1.00 82.05  ? 413 TRP B CE3 1 
ATOM   5447 C CZ2 . TRP B 1 382 ? 136.800 112.950 111.806 1.00 75.71  ? 413 TRP B CZ2 1 
ATOM   5448 C CZ3 . TRP B 1 382 ? 135.284 111.077 112.002 1.00 79.10  ? 413 TRP B CZ3 1 
ATOM   5449 C CH2 . TRP B 1 382 ? 136.165 112.009 112.569 1.00 74.24  ? 413 TRP B CH2 1 
ATOM   5450 N N   . ARG B 1 383 ? 132.624 114.101 108.333 1.00 85.40  ? 414 ARG B N   1 
ATOM   5451 C CA  . ARG B 1 383 ? 131.720 114.655 109.334 1.00 86.08  ? 414 ARG B CA  1 
ATOM   5452 C C   . ARG B 1 383 ? 130.260 114.544 108.911 1.00 87.04  ? 414 ARG B C   1 
ATOM   5453 O O   . ARG B 1 383 ? 129.374 114.595 109.771 1.00 84.97  ? 414 ARG B O   1 
ATOM   5454 C CB  . ARG B 1 383 ? 132.069 116.119 109.606 1.00 84.18  ? 414 ARG B CB  1 
ATOM   5455 C CG  . ARG B 1 383 ? 133.545 116.373 109.848 1.00 79.09  ? 414 ARG B CG  1 
ATOM   5456 C CD  . ARG B 1 383 ? 133.996 115.758 111.154 1.00 79.29  ? 414 ARG B CD  1 
ATOM   5457 N NE  . ARG B 1 383 ? 133.178 116.195 112.277 1.00 80.50  ? 414 ARG B NE  1 
ATOM   5458 C CZ  . ARG B 1 383 ? 133.157 115.599 113.461 1.00 79.07  ? 414 ARG B CZ  1 
ATOM   5459 N NH1 . ARG B 1 383 ? 133.890 114.526 113.707 1.00 77.92  ? 414 ARG B NH1 1 
ATOM   5460 N NH2 . ARG B 1 383 ? 132.380 116.092 114.421 1.00 78.97  ? 414 ARG B NH2 1 
ATOM   5461 N N   . THR B 1 384 ? 130.001 114.435 107.609 1.00 89.04  ? 415 THR B N   1 
ATOM   5462 C CA  . THR B 1 384 ? 128.675 114.153 107.079 1.00 89.38  ? 415 THR B CA  1 
ATOM   5463 C C   . THR B 1 384 ? 128.291 112.719 107.446 1.00 90.69  ? 415 THR B C   1 
ATOM   5464 O O   . THR B 1 384 ? 129.121 111.808 107.407 1.00 92.47  ? 415 THR B O   1 
ATOM   5465 C CB  . THR B 1 384 ? 128.691 114.374 105.556 1.00 92.04  ? 415 THR B CB  1 
ATOM   5466 O OG1 . THR B 1 384 ? 129.211 115.681 105.283 1.00 93.95  ? 415 THR B OG1 1 
ATOM   5467 C CG2 . THR B 1 384 ? 127.300 114.304 104.917 1.00 89.38  ? 415 THR B CG2 1 
ATOM   5468 N N   . SER B 1 385 ? 127.010 112.516 107.795 1.00 91.65  ? 416 SER B N   1 
ATOM   5469 C CA  . SER B 1 385 ? 126.557 111.298 108.471 1.00 91.76  ? 416 SER B CA  1 
ATOM   5470 C C   . SER B 1 385 ? 126.449 110.068 107.565 1.00 92.85  ? 416 SER B C   1 
ATOM   5471 O O   . SER B 1 385 ? 126.118 108.986 108.063 1.00 92.23  ? 416 SER B O   1 
ATOM   5472 C CB  . SER B 1 385 ? 125.204 111.553 109.135 1.00 90.36  ? 416 SER B CB  1 
ATOM   5473 O OG  . SER B 1 385 ? 124.735 110.393 109.797 1.00 90.63  ? 416 SER B OG  1 
ATOM   5474 N N   . GLU B 1 386 ? 126.715 110.189 106.259 1.00 93.71  ? 417 GLU B N   1 
ATOM   5475 C CA  . GLU B 1 386 ? 126.799 109.006 105.408 1.00 95.75  ? 417 GLU B CA  1 
ATOM   5476 C C   . GLU B 1 386 ? 128.113 108.253 105.616 1.00 96.60  ? 417 GLU B C   1 
ATOM   5477 O O   . GLU B 1 386 ? 128.213 107.067 105.282 1.00 96.90  ? 417 GLU B O   1 
ATOM   5478 C CB  . GLU B 1 386 ? 126.619 109.400 103.939 1.00 96.79  ? 417 GLU B CB  1 
ATOM   5479 C CG  . GLU B 1 386 ? 127.704 110.307 103.373 1.00 100.33 ? 417 GLU B CG  1 
ATOM   5480 C CD  . GLU B 1 386 ? 127.435 110.719 101.938 1.00 103.41 ? 417 GLU B CD  1 
ATOM   5481 O OE1 . GLU B 1 386 ? 126.386 110.321 101.391 1.00 101.22 ? 417 GLU B OE1 1 
ATOM   5482 O OE2 . GLU B 1 386 ? 128.274 111.440 101.358 1.00 103.10 ? 417 GLU B OE2 1 
ATOM   5483 N N   . TYR B 1 387 ? 129.133 108.921 106.167 1.00 95.28  ? 418 TYR B N   1 
ATOM   5484 C CA  . TYR B 1 387 ? 130.407 108.286 106.469 1.00 93.40  ? 418 TYR B CA  1 
ATOM   5485 C C   . TYR B 1 387 ? 130.686 108.139 107.958 1.00 91.97  ? 418 TYR B C   1 
ATOM   5486 O O   . TYR B 1 387 ? 131.579 107.369 108.325 1.00 92.62  ? 418 TYR B O   1 
ATOM   5487 C CB  . TYR B 1 387 ? 131.560 109.062 105.817 1.00 89.68  ? 418 TYR B CB  1 
ATOM   5488 C CG  . TYR B 1 387 ? 131.773 108.708 104.367 1.00 93.94  ? 418 TYR B CG  1 
ATOM   5489 C CD1 . TYR B 1 387 ? 132.218 107.430 104.006 1.00 95.50  ? 418 TYR B CD1 1 
ATOM   5490 C CD2 . TYR B 1 387 ? 131.530 109.645 103.358 1.00 95.25  ? 418 TYR B CD2 1 
ATOM   5491 C CE1 . TYR B 1 387 ? 132.417 107.089 102.669 1.00 98.89  ? 418 TYR B CE1 1 
ATOM   5492 C CE2 . TYR B 1 387 ? 131.724 109.317 102.014 1.00 97.81  ? 418 TYR B CE2 1 
ATOM   5493 C CZ  . TYR B 1 387 ? 132.168 108.038 101.684 1.00 99.83  ? 418 TYR B CZ  1 
ATOM   5494 O OH  . TYR B 1 387 ? 132.363 107.707 100.364 1.00 102.94 ? 418 TYR B OH  1 
ATOM   5495 N N   . ARG B 1 388 ? 129.957 108.843 108.819 1.00 91.29  ? 419 ARG B N   1 
ATOM   5496 C CA  . ARG B 1 388 ? 130.160 108.769 110.262 1.00 89.63  ? 419 ARG B CA  1 
ATOM   5497 C C   . ARG B 1 388 ? 129.069 107.893 110.867 1.00 89.33  ? 419 ARG B C   1 
ATOM   5498 O O   . ARG B 1 388 ? 127.889 108.256 110.846 1.00 90.26  ? 419 ARG B O   1 
ATOM   5499 C CB  . ARG B 1 388 ? 130.160 110.162 110.883 1.00 88.35  ? 419 ARG B CB  1 
ATOM   5500 C CG  . ARG B 1 388 ? 130.406 110.156 112.372 1.00 90.94  ? 419 ARG B CG  1 
ATOM   5501 C CD  . ARG B 1 388 ? 130.852 111.516 112.882 1.00 92.45  ? 419 ARG B CD  1 
ATOM   5502 N NE  . ARG B 1 388 ? 130.887 111.563 114.339 1.00 95.91  ? 419 ARG B NE  1 
ATOM   5503 C CZ  . ARG B 1 388 ? 131.908 111.162 115.086 1.00 92.42  ? 419 ARG B CZ  1 
ATOM   5504 N NH1 . ARG B 1 388 ? 133.018 110.685 114.545 1.00 88.23  ? 419 ARG B NH1 1 
ATOM   5505 N NH2 . ARG B 1 388 ? 131.814 111.244 116.410 1.00 95.08  ? 419 ARG B NH2 1 
ATOM   5506 N N   . GLN B 1 389 ? 129.467 106.746 111.412 1.00 87.51  ? 420 GLN B N   1 
ATOM   5507 C CA  . GLN B 1 389 ? 128.547 105.764 111.972 1.00 84.72  ? 420 GLN B CA  1 
ATOM   5508 C C   . GLN B 1 389 ? 128.854 105.565 113.448 1.00 81.98  ? 420 GLN B C   1 
ATOM   5509 O O   . GLN B 1 389 ? 129.978 105.815 113.890 1.00 80.79  ? 420 GLN B O   1 
ATOM   5510 C CB  . GLN B 1 389 ? 128.652 104.425 111.236 1.00 85.31  ? 420 GLN B CB  1 
ATOM   5511 C CG  . GLN B 1 389 ? 128.513 104.517 109.728 1.00 88.47  ? 420 GLN B CG  1 
ATOM   5512 C CD  . GLN B 1 389 ? 129.018 103.275 109.027 1.00 89.21  ? 420 GLN B CD  1 
ATOM   5513 O OE1 . GLN B 1 389 ? 129.538 102.360 109.663 1.00 88.84  ? 420 GLN B OE1 1 
ATOM   5514 N NE2 . GLN B 1 389 ? 128.865 103.234 107.709 1.00 86.89  ? 420 GLN B NE2 1 
ATOM   5515 N N   . ALA B 1 390 ? 127.855 105.130 114.210 1.00 81.27  ? 421 ALA B N   1 
ATOM   5516 C CA  . ALA B 1 390 ? 128.089 104.771 115.600 1.00 76.23  ? 421 ALA B CA  1 
ATOM   5517 C C   . ALA B 1 390 ? 128.514 103.310 115.705 1.00 74.94  ? 421 ALA B C   1 
ATOM   5518 O O   . ALA B 1 390 ? 127.925 102.423 115.083 1.00 72.38  ? 421 ALA B O   1 
ATOM   5519 C CB  . ALA B 1 390 ? 126.837 105.019 116.438 1.00 70.72  ? 421 ALA B CB  1 
ATOM   5520 N N   . HIS B 1 391 ? 129.552 103.065 116.504 1.00 74.03  ? 422 HIS B N   1 
ATOM   5521 C CA  . HIS B 1 391 ? 130.112 101.732 116.669 1.00 69.29  ? 422 HIS B CA  1 
ATOM   5522 C C   . HIS B 1 391 ? 129.892 101.237 118.088 1.00 65.39  ? 422 HIS B C   1 
ATOM   5523 O O   . HIS B 1 391 ? 130.026 101.991 119.056 1.00 64.86  ? 422 HIS B O   1 
ATOM   5524 C CB  . HIS B 1 391 ? 131.614 101.694 116.370 1.00 69.47  ? 422 HIS B CB  1 
ATOM   5525 C CG  . HIS B 1 391 ? 131.979 102.214 115.018 1.00 72.59  ? 422 HIS B CG  1 
ATOM   5526 N ND1 . HIS B 1 391 ? 132.007 101.415 113.896 1.00 72.87  ? 422 HIS B ND1 1 
ATOM   5527 C CD2 . HIS B 1 391 ? 132.344 103.450 114.609 1.00 73.96  ? 422 HIS B CD2 1 
ATOM   5528 C CE1 . HIS B 1 391 ? 132.365 102.139 112.852 1.00 72.92  ? 422 HIS B CE1 1 
ATOM   5529 N NE2 . HIS B 1 391 ? 132.575 103.378 113.257 1.00 76.24  ? 422 HIS B NE2 1 
ATOM   5530 N N   . ASP B 1 392 ? 129.557 99.955  118.198 1.00 62.00  ? 423 ASP B N   1 
ATOM   5531 C CA  . ASP B 1 392 ? 129.506 99.284  119.484 1.00 60.29  ? 423 ASP B CA  1 
ATOM   5532 C C   . ASP B 1 392 ? 130.921 99.052  120.001 1.00 58.90  ? 423 ASP B C   1 
ATOM   5533 O O   . ASP B 1 392 ? 131.882 98.998  119.232 1.00 61.36  ? 423 ASP B O   1 
ATOM   5534 C CB  . ASP B 1 392 ? 128.752 97.961  119.366 1.00 62.40  ? 423 ASP B CB  1 
ATOM   5535 C CG  . ASP B 1 392 ? 128.075 97.557  120.660 1.00 65.65  ? 423 ASP B CG  1 
ATOM   5536 O OD1 . ASP B 1 392 ? 127.966 98.408  121.568 1.00 64.72  ? 423 ASP B OD1 1 
ATOM   5537 O OD2 . ASP B 1 392 ? 127.652 96.387  120.770 1.00 63.88  ? 423 ASP B OD2 1 
ATOM   5538 N N   . THR B 1 393 ? 131.031 98.911  121.327 1.00 57.38  ? 424 THR B N   1 
ATOM   5539 C CA  . THR B 1 393 ? 132.328 98.796  121.995 1.00 53.80  ? 424 THR B CA  1 
ATOM   5540 C C   . THR B 1 393 ? 132.960 97.429  121.728 1.00 54.16  ? 424 THR B C   1 
ATOM   5541 O O   . THR B 1 393 ? 134.173 97.324  121.505 1.00 56.46  ? 424 THR B O   1 
ATOM   5542 C CB  . THR B 1 393 ? 132.121 99.088  123.493 1.00 56.17  ? 424 THR B CB  1 
ATOM   5543 O OG1 . THR B 1 393 ? 131.908 100.495 123.665 1.00 57.54  ? 424 THR B OG1 1 
ATOM   5544 C CG2 . THR B 1 393 ? 133.293 98.678  124.393 1.00 57.39  ? 424 THR B CG2 1 
ATOM   5545 N N   . ALA B 1 394 ? 132.128 96.398  121.574 1.00 54.31  ? 425 ALA B N   1 
ATOM   5546 C CA  . ALA B 1 394 ? 132.637 95.084  121.188 1.00 51.48  ? 425 ALA B CA  1 
ATOM   5547 C C   . ALA B 1 394 ? 132.912 94.999  119.690 1.00 52.27  ? 425 ALA B C   1 
ATOM   5548 O O   . ALA B 1 394 ? 133.548 94.045  119.230 1.00 51.50  ? 425 ALA B O   1 
ATOM   5549 C CB  . ALA B 1 394 ? 131.653 93.995  121.608 1.00 51.98  ? 425 ALA B CB  1 
ATOM   5550 N N   . GLU B 1 395 ? 132.416 95.963  118.909 1.00 55.92  ? 426 GLU B N   1 
ATOM   5551 C CA  . GLU B 1 395 ? 132.767 96.031  117.494 1.00 55.14  ? 426 GLU B CA  1 
ATOM   5552 C C   . GLU B 1 395 ? 134.078 96.783  117.291 1.00 50.97  ? 426 GLU B C   1 
ATOM   5553 O O   . GLU B 1 395 ? 134.811 96.514  116.332 1.00 54.66  ? 426 GLU B O   1 
ATOM   5554 C CB  . GLU B 1 395 ? 131.626 96.690  116.712 1.00 62.50  ? 426 GLU B CB  1 
ATOM   5555 C CG  . GLU B 1 395 ? 131.667 96.499  115.201 1.00 66.91  ? 426 GLU B CG  1 
ATOM   5556 C CD  . GLU B 1 395 ? 130.608 97.312  114.482 1.00 77.00  ? 426 GLU B CD  1 
ATOM   5557 O OE1 . GLU B 1 395 ? 129.829 98.015  115.160 1.00 73.79  ? 426 GLU B OE1 1 
ATOM   5558 O OE2 . GLU B 1 395 ? 130.549 97.239  113.237 1.00 85.06  ? 426 GLU B OE2 1 
ATOM   5559 N N   . ILE B 1 396 ? 134.384 97.731  118.188 1.00 47.41  ? 427 ILE B N   1 
ATOM   5560 C CA  . ILE B 1 396 ? 135.646 98.474  118.142 1.00 44.93  ? 427 ILE B CA  1 
ATOM   5561 C C   . ILE B 1 396 ? 136.815 97.565  118.516 1.00 47.38  ? 427 ILE B C   1 
ATOM   5562 O O   . ILE B 1 396 ? 137.849 97.544  117.837 1.00 53.64  ? 427 ILE B O   1 
ATOM   5563 C CB  . ILE B 1 396 ? 135.558 99.718  119.053 1.00 44.32  ? 427 ILE B CB  1 
ATOM   5564 C CG1 . ILE B 1 396 ? 134.624 100.761 118.452 1.00 45.13  ? 427 ILE B CG1 1 
ATOM   5565 C CG2 . ILE B 1 396 ? 136.907 100.374 119.306 1.00 45.20  ? 427 ILE B CG2 1 
ATOM   5566 C CD1 . ILE B 1 396 ? 134.292 101.899 119.391 1.00 44.20  ? 427 ILE B CD1 1 
ATOM   5567 N N   . LEU B 1 397 ? 136.629 96.738  119.551 1.00 45.11  ? 428 LEU B N   1 
ATOM   5568 C CA  . LEU B 1 397 ? 137.692 95.858  120.031 1.00 44.28  ? 428 LEU B CA  1 
ATOM   5569 C C   . LEU B 1 397 ? 137.914 94.670  119.103 1.00 45.91  ? 428 LEU B C   1 
ATOM   5570 O O   . LEU B 1 397 ? 138.999 94.081  119.092 1.00 48.03  ? 428 LEU B O   1 
ATOM   5571 C CB  . LEU B 1 397 ? 137.357 95.343  121.428 1.00 49.39  ? 428 LEU B CB  1 
ATOM   5572 C CG  . LEU B 1 397 ? 137.247 96.262  122.639 1.00 51.50  ? 428 LEU B CG  1 
ATOM   5573 C CD1 . LEU B 1 397 ? 137.365 95.416  123.884 1.00 51.63  ? 428 LEU B CD1 1 
ATOM   5574 C CD2 . LEU B 1 397 ? 138.300 97.341  122.630 1.00 59.06  ? 428 LEU B CD2 1 
ATOM   5575 N N   . SER B 1 398 ? 136.900 94.291  118.331 1.00 47.63  ? 429 SER B N   1 
ATOM   5576 C CA  . SER B 1 398 ? 137.072 93.188  117.396 1.00 48.69  ? 429 SER B CA  1 
ATOM   5577 C C   . SER B 1 398 ? 137.757 93.658  116.121 1.00 53.61  ? 429 SER B C   1 
ATOM   5578 O O   . SER B 1 398 ? 138.547 92.919  115.521 1.00 55.72  ? 429 SER B O   1 
ATOM   5579 C CB  . SER B 1 398 ? 135.721 92.548  117.083 1.00 51.26  ? 429 SER B CB  1 
ATOM   5580 O OG  . SER B 1 398 ? 134.881 93.443  116.374 1.00 53.82  ? 429 SER B OG  1 
ATOM   5581 N N   . LEU B 1 399 ? 137.458 94.887  115.688 1.00 51.38  ? 430 LEU B N   1 
ATOM   5582 C CA  . LEU B 1 399 ? 138.027 95.408  114.450 1.00 46.49  ? 430 LEU B CA  1 
ATOM   5583 C C   . LEU B 1 399 ? 139.475 95.829  114.618 1.00 50.00  ? 430 LEU B C   1 
ATOM   5584 O O   . LEU B 1 399 ? 140.286 95.618  113.712 1.00 57.64  ? 430 LEU B O   1 
ATOM   5585 C CB  . LEU B 1 399 ? 137.210 96.595  113.945 1.00 46.25  ? 430 LEU B CB  1 
ATOM   5586 C CG  . LEU B 1 399 ? 135.955 96.302  113.126 1.00 55.81  ? 430 LEU B CG  1 
ATOM   5587 C CD1 . LEU B 1 399 ? 135.355 97.603  112.625 1.00 61.57  ? 430 LEU B CD1 1 
ATOM   5588 C CD2 . LEU B 1 399 ? 136.262 95.365  111.964 1.00 52.16  ? 430 LEU B CD2 1 
ATOM   5589 N N   . LEU B 1 400 ? 139.823 96.405  115.767 1.00 47.47  ? 431 LEU B N   1 
ATOM   5590 C CA  . LEU B 1 400 ? 141.123 97.025  115.967 1.00 43.22  ? 431 LEU B CA  1 
ATOM   5591 C C   . LEU B 1 400 ? 142.168 96.072  116.519 1.00 41.98  ? 431 LEU B C   1 
ATOM   5592 O O   . LEU B 1 400 ? 143.258 96.539  116.860 1.00 45.95  ? 431 LEU B O   1 
ATOM   5593 C CB  . LEU B 1 400 ? 141.004 98.236  116.886 1.00 40.90  ? 431 LEU B CB  1 
ATOM   5594 C CG  . LEU B 1 400 ? 140.609 99.543  116.217 1.00 42.37  ? 431 LEU B CG  1 
ATOM   5595 C CD1 . LEU B 1 400 ? 140.549 100.624 117.249 1.00 43.16  ? 431 LEU B CD1 1 
ATOM   5596 C CD2 . LEU B 1 400 ? 141.622 99.906  115.163 1.00 39.90  ? 431 LEU B CD2 1 
ATOM   5597 N N   . LEU B 1 401 ? 141.834 94.773  116.620 1.00 41.79  ? 432 LEU B N   1 
ATOM   5598 C CA  . LEU B 1 401 ? 142.709 93.657  117.035 1.00 43.99  ? 432 LEU B CA  1 
ATOM   5599 C C   . LEU B 1 401 ? 143.238 93.855  118.455 1.00 44.17  ? 432 LEU B C   1 
ATOM   5600 O O   . LEU B 1 401 ? 144.439 93.801  118.717 1.00 46.10  ? 432 LEU B O   1 
ATOM   5601 C CB  . LEU B 1 401 ? 143.852 93.410  116.035 1.00 44.70  ? 432 LEU B CB  1 
ATOM   5602 C CG  . LEU B 1 401 ? 143.687 92.464  114.838 1.00 52.95  ? 432 LEU B CG  1 
ATOM   5603 C CD1 . LEU B 1 401 ? 142.627 92.908  113.843 1.00 58.26  ? 432 LEU B CD1 1 
ATOM   5604 C CD2 . LEU B 1 401 ? 145.019 92.338  114.133 1.00 43.67  ? 432 LEU B CD2 1 
ATOM   5605 N N   . MET B 1 402 ? 142.316 94.148  119.363 1.00 45.39  ? 433 MET B N   1 
ATOM   5606 C CA  . MET B 1 402 ? 142.587 94.370  120.776 1.00 42.36  ? 433 MET B CA  1 
ATOM   5607 C C   . MET B 1 402 ? 141.485 93.734  121.644 1.00 48.78  ? 433 MET B C   1 
ATOM   5608 O O   . MET B 1 402 ? 141.144 94.206  122.735 1.00 52.78  ? 433 MET B O   1 
ATOM   5609 C CB  . MET B 1 402 ? 142.871 95.867  121.001 1.00 42.59  ? 433 MET B CB  1 
ATOM   5610 C CG  . MET B 1 402 ? 141.738 96.920  121.014 1.00 46.90  ? 433 MET B CG  1 
ATOM   5611 S SD  . MET B 1 402 ? 142.391 98.594  120.943 1.00 60.81  ? 433 MET B SD  1 
ATOM   5612 C CE  . MET B 1 402 ? 140.881 99.547  120.903 1.00 53.08  ? 433 MET B CE  1 
ATOM   5613 N N   . ARG B 1 403 ? 141.033 92.540  121.233 1.00 50.41  ? 434 ARG B N   1 
ATOM   5614 C CA  . ARG B 1 403 ? 139.849 91.925  121.836 1.00 50.27  ? 434 ARG B CA  1 
ATOM   5615 C C   . ARG B 1 403 ? 140.157 91.235  123.164 1.00 53.09  ? 434 ARG B C   1 
ATOM   5616 O O   . ARG B 1 403 ? 139.234 90.835  123.881 1.00 55.03  ? 434 ARG B O   1 
ATOM   5617 C CB  . ARG B 1 403 ? 139.223 90.913  120.879 1.00 51.43  ? 434 ARG B CB  1 
ATOM   5618 C CG  . ARG B 1 403 ? 140.036 89.644  120.713 1.00 57.95  ? 434 ARG B CG  1 
ATOM   5619 C CD  . ARG B 1 403 ? 139.705 88.902  119.428 1.00 65.02  ? 434 ARG B CD  1 
ATOM   5620 N NE  . ARG B 1 403 ? 139.778 89.760  118.254 1.00 63.69  ? 434 ARG B NE  1 
ATOM   5621 C CZ  . ARG B 1 403 ? 138.885 89.762  117.276 1.00 64.89  ? 434 ARG B CZ  1 
ATOM   5622 N NH1 . ARG B 1 403 ? 137.823 88.974  117.308 1.00 60.26  ? 434 ARG B NH1 1 
ATOM   5623 N NH2 . ARG B 1 403 ? 139.062 90.575  116.239 1.00 67.21  ? 434 ARG B NH2 1 
ATOM   5624 N N   . LYS B 1 404 ? 141.436 91.078  123.513 1.00 53.76  ? 435 LYS B N   1 
ATOM   5625 C CA  . LYS B 1 404 ? 141.790 90.571  124.833 1.00 47.32  ? 435 LYS B CA  1 
ATOM   5626 C C   . LYS B 1 404 ? 141.788 91.647  125.904 1.00 46.72  ? 435 LYS B C   1 
ATOM   5627 O O   . LYS B 1 404 ? 141.948 91.317  127.082 1.00 51.09  ? 435 LYS B O   1 
ATOM   5628 C CB  . LYS B 1 404 ? 143.164 89.903  124.820 1.00 48.19  ? 435 LYS B CB  1 
ATOM   5629 C CG  . LYS B 1 404 ? 143.204 88.497  124.276 1.00 50.24  ? 435 LYS B CG  1 
ATOM   5630 C CD  . LYS B 1 404 ? 144.585 87.910  124.501 1.00 52.21  ? 435 LYS B CD  1 
ATOM   5631 C CE  . LYS B 1 404 ? 144.665 86.467  124.049 1.00 54.36  ? 435 LYS B CE  1 
ATOM   5632 N NZ  . LYS B 1 404 ? 146.065 85.966  124.101 1.00 56.93  ? 435 LYS B NZ  1 
ATOM   5633 N N   . LEU B 1 405 ? 141.607 92.915  125.543 1.00 46.62  ? 436 LEU B N   1 
ATOM   5634 C CA  . LEU B 1 405 ? 141.585 93.984  126.528 1.00 48.35  ? 436 LEU B CA  1 
ATOM   5635 C C   . LEU B 1 405 ? 140.246 94.140  127.220 1.00 48.64  ? 436 LEU B C   1 
ATOM   5636 O O   . LEU B 1 405 ? 140.175 94.904  128.186 1.00 52.43  ? 436 LEU B O   1 
ATOM   5637 C CB  . LEU B 1 405 ? 141.933 95.337  125.905 1.00 47.63  ? 436 LEU B CB  1 
ATOM   5638 C CG  . LEU B 1 405 ? 143.370 95.818  125.787 1.00 45.80  ? 436 LEU B CG  1 
ATOM   5639 C CD1 . LEU B 1 405 ? 144.059 95.171  124.626 1.00 46.29  ? 436 LEU B CD1 1 
ATOM   5640 C CD2 . LEU B 1 405 ? 143.385 97.323  125.658 1.00 46.30  ? 436 LEU B CD2 1 
ATOM   5641 N N   . GLY B 1 406 ? 139.210 93.414  126.782 1.00 45.14  ? 437 GLY B N   1 
ATOM   5642 C CA  . GLY B 1 406 ? 137.854 93.685  127.244 1.00 45.62  ? 437 GLY B CA  1 
ATOM   5643 C C   . GLY B 1 406 ? 137.589 93.211  128.660 1.00 40.90  ? 437 GLY B C   1 
ATOM   5644 O O   . GLY B 1 406 ? 136.670 93.689  129.325 1.00 39.77  ? 437 GLY B O   1 
ATOM   5645 N N   . THR B 1 407 ? 138.405 92.276  129.148 1.00 41.17  ? 438 THR B N   1 
ATOM   5646 C CA  . THR B 1 407 ? 138.356 91.934  130.562 1.00 39.25  ? 438 THR B CA  1 
ATOM   5647 C C   . THR B 1 407 ? 139.026 93.010  131.407 1.00 37.85  ? 438 THR B C   1 
ATOM   5648 O O   . THR B 1 407 ? 138.705 93.169  132.589 1.00 41.37  ? 438 THR B O   1 
ATOM   5649 C CB  . THR B 1 407 ? 139.018 90.580  130.798 1.00 42.88  ? 438 THR B CB  1 
ATOM   5650 O OG1 . THR B 1 407 ? 140.425 90.690  130.564 1.00 45.05  ? 438 THR B OG1 1 
ATOM   5651 C CG2 . THR B 1 407 ? 138.445 89.541  129.849 1.00 39.75  ? 438 THR B CG2 1 
ATOM   5652 N N   . ALA B 1 408 ? 139.965 93.757  130.821 1.00 37.01  ? 439 ALA B N   1 
ATOM   5653 C CA  . ALA B 1 408 ? 140.718 94.763  131.561 1.00 38.80  ? 439 ALA B CA  1 
ATOM   5654 C C   . ALA B 1 408 ? 140.112 96.158  131.479 1.00 37.46  ? 439 ALA B C   1 
ATOM   5655 O O   . ALA B 1 408 ? 140.591 97.056  132.180 1.00 41.01  ? 439 ALA B O   1 
ATOM   5656 C CB  . ALA B 1 408 ? 142.163 94.799  131.063 1.00 38.22  ? 439 ALA B CB  1 
ATOM   5657 N N   . MET B 1 409 ? 139.093 96.368  130.651 1.00 32.53  ? 440 MET B N   1 
ATOM   5658 C CA  . MET B 1 409 ? 138.374 97.641  130.600 1.00 30.11  ? 440 MET B CA  1 
ATOM   5659 C C   . MET B 1 409 ? 137.268 97.599  131.643 1.00 29.88  ? 440 MET B C   1 
ATOM   5660 O O   . MET B 1 409 ? 136.191 97.058  131.394 1.00 42.42  ? 440 MET B O   1 
ATOM   5661 C CB  . MET B 1 409 ? 137.798 97.887  129.210 1.00 36.03  ? 440 MET B CB  1 
ATOM   5662 C CG  . MET B 1 409 ? 138.806 97.927  128.089 1.00 43.04  ? 440 MET B CG  1 
ATOM   5663 S SD  . MET B 1 409 ? 138.388 99.090  126.796 1.00 62.15  ? 440 MET B SD  1 
ATOM   5664 C CE  . MET B 1 409 ? 136.856 98.350  126.256 1.00 52.18  ? 440 MET B CE  1 
ATOM   5665 N N   . ASN B 1 410 ? 137.524 98.175  132.814 1.00 22.45  ? 441 ASN B N   1 
ATOM   5666 C CA  . ASN B 1 410 ? 136.537 98.201  133.882 1.00 18.33  ? 441 ASN B CA  1 
ATOM   5667 C C   . ASN B 1 410 ? 136.386 99.622  134.393 1.00 16.69  ? 441 ASN B C   1 
ATOM   5668 O O   . ASN B 1 410 ? 137.301 100.437 134.261 1.00 22.77  ? 441 ASN B O   1 
ATOM   5669 C CB  . ASN B 1 410 ? 136.928 97.289  135.045 1.00 18.33  ? 441 ASN B CB  1 
ATOM   5670 C CG  . ASN B 1 410 ? 137.029 95.842  134.644 1.00 21.17  ? 441 ASN B CG  1 
ATOM   5671 O OD1 . ASN B 1 410 ? 136.028 95.143  134.537 1.00 22.32  ? 441 ASN B OD1 1 
ATOM   5672 N ND2 . ASN B 1 410 ? 138.249 95.374  134.443 1.00 24.37  ? 441 ASN B ND2 1 
ATOM   5673 N N   . PHE B 1 411 ? 135.223 99.917  134.957 1.00 13.88  ? 442 PHE B N   1 
ATOM   5674 C CA  . PHE B 1 411 ? 134.999 101.140 135.712 1.00 12.94  ? 442 PHE B CA  1 
ATOM   5675 C C   . PHE B 1 411 ? 134.608 100.741 137.127 1.00 17.00  ? 442 PHE B C   1 
ATOM   5676 O O   . PHE B 1 411 ? 133.527 100.184 137.336 1.00 21.78  ? 442 PHE B O   1 
ATOM   5677 C CB  . PHE B 1 411 ? 133.910 101.992 135.071 1.00 13.34  ? 442 PHE B CB  1 
ATOM   5678 C CG  . PHE B 1 411 ? 133.819 103.363 135.640 1.00 13.70  ? 442 PHE B CG  1 
ATOM   5679 C CD1 . PHE B 1 411 ? 134.784 104.315 135.333 1.00 16.03  ? 442 PHE B CD1 1 
ATOM   5680 C CD2 . PHE B 1 411 ? 132.777 103.700 136.492 1.00 14.47  ? 442 PHE B CD2 1 
ATOM   5681 C CE1 . PHE B 1 411 ? 134.714 105.593 135.875 1.00 18.40  ? 442 PHE B CE1 1 
ATOM   5682 C CE2 . PHE B 1 411 ? 132.691 104.972 137.040 1.00 15.33  ? 442 PHE B CE2 1 
ATOM   5683 C CZ  . PHE B 1 411 ? 133.666 105.917 136.723 1.00 17.96  ? 442 PHE B CZ  1 
ATOM   5684 N N   . GLN B 1 412 ? 135.479 101.019 138.091 1.00 14.73  ? 443 GLN B N   1 
ATOM   5685 C CA  . GLN B 1 412 ? 135.395 100.395 139.401 1.00 16.41  ? 443 GLN B CA  1 
ATOM   5686 C C   . GLN B 1 412 ? 135.137 101.421 140.494 1.00 18.87  ? 443 GLN B C   1 
ATOM   5687 O O   . GLN B 1 412 ? 135.349 102.620 140.307 1.00 22.21  ? 443 GLN B O   1 
ATOM   5688 C CB  . GLN B 1 412 ? 136.673 99.614  139.700 1.00 16.30  ? 443 GLN B CB  1 
ATOM   5689 C CG  . GLN B 1 412 ? 136.815 98.408  138.805 1.00 21.04  ? 443 GLN B CG  1 
ATOM   5690 C CD  . GLN B 1 412 ? 137.981 97.530  139.156 1.00 26.19  ? 443 GLN B CD  1 
ATOM   5691 O OE1 . GLN B 1 412 ? 138.768 97.852  140.033 1.00 31.07  ? 443 GLN B OE1 1 
ATOM   5692 N NE2 . GLN B 1 412 ? 138.080 96.386  138.493 1.00 23.76  ? 443 GLN B NE2 1 
ATOM   5693 N N   . MET B 1 413 ? 134.650 100.940 141.633 1.00 17.98  ? 444 MET B N   1 
ATOM   5694 C CA  . MET B 1 413 ? 134.462 101.768 142.816 1.00 16.68  ? 444 MET B CA  1 
ATOM   5695 C C   . MET B 1 413 ? 135.364 101.267 143.934 1.00 20.73  ? 444 MET B C   1 
ATOM   5696 O O   . MET B 1 413 ? 135.305 100.091 144.300 1.00 24.29  ? 444 MET B O   1 
ATOM   5697 C CB  . MET B 1 413 ? 133.005 101.777 143.272 1.00 21.12  ? 444 MET B CB  1 
ATOM   5698 C CG  . MET B 1 413 ? 132.679 102.906 144.241 1.00 24.18  ? 444 MET B CG  1 
ATOM   5699 S SD  . MET B 1 413 ? 130.922 103.259 144.436 1.00 30.47  ? 444 MET B SD  1 
ATOM   5700 C CE  . MET B 1 413 ? 130.230 101.609 144.442 1.00 18.55  ? 444 MET B CE  1 
ATOM   5701 N N   . TYR B 1 414 ? 136.190 102.161 144.471 1.00 20.85  ? 445 TYR B N   1 
ATOM   5702 C CA  . TYR B 1 414 ? 137.173 101.832 145.490 1.00 20.27  ? 445 TYR B CA  1 
ATOM   5703 C C   . TYR B 1 414 ? 136.862 102.597 146.763 1.00 23.98  ? 445 TYR B C   1 
ATOM   5704 O O   . TYR B 1 414 ? 136.537 103.780 146.714 1.00 33.30  ? 445 TYR B O   1 
ATOM   5705 C CB  . TYR B 1 414 ? 138.581 102.210 145.051 1.00 20.75  ? 445 TYR B CB  1 
ATOM   5706 C CG  . TYR B 1 414 ? 139.177 101.349 143.978 1.00 22.16  ? 445 TYR B CG  1 
ATOM   5707 C CD1 . TYR B 1 414 ? 139.694 100.091 144.287 1.00 25.27  ? 445 TYR B CD1 1 
ATOM   5708 C CD2 . TYR B 1 414 ? 139.258 101.808 142.660 1.00 21.21  ? 445 TYR B CD2 1 
ATOM   5709 C CE1 . TYR B 1 414 ? 140.266 99.293  143.307 1.00 26.06  ? 445 TYR B CE1 1 
ATOM   5710 C CE2 . TYR B 1 414 ? 139.824 101.019 141.666 1.00 23.81  ? 445 TYR B CE2 1 
ATOM   5711 C CZ  . TYR B 1 414 ? 140.327 99.767  142.006 1.00 26.64  ? 445 TYR B CZ  1 
ATOM   5712 O OH  . TYR B 1 414 ? 140.887 98.970  141.035 1.00 29.12  ? 445 TYR B OH  1 
ATOM   5713 N N   . GLN B 1 415 ? 136.998 101.936 147.906 1.00 20.73  ? 446 GLN B N   1 
ATOM   5714 C CA  . GLN B 1 415 ? 136.832 102.582 149.201 1.00 22.27  ? 446 GLN B CA  1 
ATOM   5715 C C   . GLN B 1 415 ? 138.180 102.648 149.899 1.00 27.31  ? 446 GLN B C   1 
ATOM   5716 O O   . GLN B 1 415 ? 138.806 101.612 150.138 1.00 36.56  ? 446 GLN B O   1 
ATOM   5717 C CB  . GLN B 1 415 ? 135.835 101.829 150.080 1.00 24.26  ? 446 GLN B CB  1 
ATOM   5718 C CG  . GLN B 1 415 ? 135.699 102.421 151.464 1.00 27.98  ? 446 GLN B CG  1 
ATOM   5719 C CD  . GLN B 1 415 ? 134.315 102.263 152.051 1.00 36.54  ? 446 GLN B CD  1 
ATOM   5720 O OE1 . GLN B 1 415 ? 133.640 101.262 151.824 1.00 45.99  ? 446 GLN B OE1 1 
ATOM   5721 N NE2 . GLN B 1 415 ? 133.882 103.258 152.808 1.00 35.12  ? 446 GLN B NE2 1 
ATOM   5722 N N   . LYS B 1 416 ? 138.620 103.857 150.236 1.00 24.19  ? 447 LYS B N   1 
ATOM   5723 C CA  . LYS B 1 416 ? 139.879 104.056 150.940 1.00 21.26  ? 447 LYS B CA  1 
ATOM   5724 C C   . LYS B 1 416 ? 139.659 103.745 152.413 1.00 25.77  ? 447 LYS B C   1 
ATOM   5725 O O   . LYS B 1 416 ? 138.971 104.493 153.106 1.00 36.36  ? 447 LYS B O   1 
ATOM   5726 C CB  . LYS B 1 416 ? 140.373 105.492 150.757 1.00 20.76  ? 447 LYS B CB  1 
ATOM   5727 C CG  . LYS B 1 416 ? 141.571 105.907 151.621 1.00 28.77  ? 447 LYS B CG  1 
ATOM   5728 C CD  . LYS B 1 416 ? 141.984 107.331 151.324 1.00 34.05  ? 447 LYS B CD  1 
ATOM   5729 C CE  . LYS B 1 416 ? 143.068 107.825 152.262 1.00 34.35  ? 447 LYS B CE  1 
ATOM   5730 N NZ  . LYS B 1 416 ? 142.549 108.086 153.631 1.00 43.44  ? 447 LYS B NZ  1 
ATOM   5731 N N   . LYS B 1 417 ? 140.205 102.635 152.890 1.00 24.73  ? 448 LYS B N   1 
ATOM   5732 C CA  . LYS B 1 417 ? 140.116 102.298 154.305 1.00 34.44  ? 448 LYS B CA  1 
ATOM   5733 C C   . LYS B 1 417 ? 141.513 102.232 154.892 1.00 39.87  ? 448 LYS B C   1 
ATOM   5734 O O   . LYS B 1 417 ? 142.319 101.391 154.486 1.00 48.44  ? 448 LYS B O   1 
ATOM   5735 C CB  . LYS B 1 417 ? 139.379 100.979 154.540 1.00 42.26  ? 448 LYS B CB  1 
ATOM   5736 C CG  . LYS B 1 417 ? 137.928 100.983 154.115 1.00 43.17  ? 448 LYS B CG  1 
ATOM   5737 C CD  . LYS B 1 417 ? 137.103 100.044 154.975 1.00 43.10  ? 448 LYS B CD  1 
ATOM   5738 C CE  . LYS B 1 417 ? 135.623 100.204 154.707 1.00 51.58  ? 448 LYS B CE  1 
ATOM   5739 N NZ  . LYS B 1 417 ? 134.827 99.256  155.530 1.00 64.76  ? 448 LYS B NZ  1 
ATOM   5740 N N   . VAL B 1 418 ? 141.788 103.109 155.853 1.00 41.35  ? 449 VAL B N   1 
ATOM   5741 C CA  . VAL B 1 418 ? 143.087 103.154 156.521 1.00 49.73  ? 449 VAL B CA  1 
ATOM   5742 C C   . VAL B 1 418 ? 143.008 102.140 157.658 1.00 54.32  ? 449 VAL B C   1 
ATOM   5743 O O   . VAL B 1 418 ? 142.135 102.203 158.523 1.00 54.31  ? 449 VAL B O   1 
ATOM   5744 C CB  . VAL B 1 418 ? 143.430 104.560 157.006 1.00 50.70  ? 449 VAL B CB  1 
ATOM   5745 C CG1 . VAL B 1 418 ? 144.739 104.565 157.791 1.00 47.75  ? 449 VAL B CG1 1 
ATOM   5746 C CG2 . VAL B 1 418 ? 143.506 105.516 155.825 1.00 46.03  ? 449 VAL B CG2 1 
ATOM   5747 N N   . LEU B 1 419 ? 143.927 101.182 157.643 1.00 58.24  ? 450 LEU B N   1 
ATOM   5748 C CA  . LEU B 1 419 ? 143.917 100.102 158.621 1.00 63.06  ? 450 LEU B CA  1 
ATOM   5749 C C   . LEU B 1 419 ? 144.722 100.512 159.847 1.00 63.98  ? 450 LEU B C   1 
ATOM   5750 O O   . LEU B 1 419 ? 145.101 99.671  160.663 1.00 68.08  ? 450 LEU B O   1 
ATOM   5751 C CB  . LEU B 1 419 ? 144.482 98.796  158.035 1.00 64.03  ? 450 LEU B CB  1 
ATOM   5752 C CG  . LEU B 1 419 ? 143.686 97.866  157.100 1.00 59.47  ? 450 LEU B CG  1 
ATOM   5753 C CD1 . LEU B 1 419 ? 143.510 98.407  155.677 1.00 55.83  ? 450 LEU B CD1 1 
ATOM   5754 C CD2 . LEU B 1 419 ? 144.304 96.472  157.080 1.00 58.22  ? 450 LEU B CD2 1 
ATOM   5755 N N   . THR B 1 430 ? 146.778 102.807 155.090 1.00 40.82  ? 461 THR B N   1 
ATOM   5756 C CA  . THR B 1 430 ? 146.069 103.340 153.933 1.00 45.05  ? 461 THR B CA  1 
ATOM   5757 C C   . THR B 1 430 ? 146.027 102.324 152.804 1.00 46.07  ? 461 THR B C   1 
ATOM   5758 O O   . THR B 1 430 ? 147.064 101.981 152.241 1.00 49.23  ? 461 THR B O   1 
ATOM   5759 C CB  . THR B 1 430 ? 146.722 104.633 153.409 1.00 46.13  ? 461 THR B CB  1 
ATOM   5760 O OG1 . THR B 1 430 ? 146.907 105.558 154.488 1.00 47.37  ? 461 THR B OG1 1 
ATOM   5761 C CG2 . THR B 1 430 ? 145.855 105.267 152.339 1.00 45.19  ? 461 THR B CG2 1 
ATOM   5762 N N   . GLU B 1 431 ? 144.831 101.850 152.464 1.00 43.46  ? 462 GLU B N   1 
ATOM   5763 C CA  . GLU B 1 431 ? 144.664 100.851 151.418 1.00 45.88  ? 462 GLU B CA  1 
ATOM   5764 C C   . GLU B 1 431 ? 143.285 100.983 150.796 1.00 45.79  ? 462 GLU B C   1 
ATOM   5765 O O   . GLU B 1 431 ? 142.276 100.776 151.474 1.00 50.03  ? 462 GLU B O   1 
ATOM   5766 C CB  . GLU B 1 431 ? 144.851 99.435  151.964 1.00 49.94  ? 462 GLU B CB  1 
ATOM   5767 C CG  . GLU B 1 431 ? 144.742 98.366  150.900 1.00 53.34  ? 462 GLU B CG  1 
ATOM   5768 C CD  . GLU B 1 431 ? 144.531 96.985  151.475 1.00 61.95  ? 462 GLU B CD  1 
ATOM   5769 O OE1 . GLU B 1 431 ? 144.255 96.880  152.688 1.00 66.17  ? 462 GLU B OE1 1 
ATOM   5770 O OE2 . GLU B 1 431 ? 144.643 96.002  150.713 1.00 65.61  ? 462 GLU B OE2 1 
ATOM   5771 N N   . LEU B 1 432 ? 143.249 101.312 149.507 1.00 44.16  ? 463 LEU B N   1 
ATOM   5772 C CA  . LEU B 1 432 ? 142.007 101.457 148.748 1.00 42.01  ? 463 LEU B CA  1 
ATOM   5773 C C   . LEU B 1 432 ? 141.502 100.078 148.346 1.00 41.42  ? 463 LEU B C   1 
ATOM   5774 O O   . LEU B 1 432 ? 141.821 99.588  147.261 1.00 41.86  ? 463 LEU B O   1 
ATOM   5775 C CB  . LEU B 1 432 ? 142.219 102.327 147.514 1.00 36.41  ? 463 LEU B CB  1 
ATOM   5776 C CG  . LEU B 1 432 ? 141.992 103.836 147.607 1.00 33.53  ? 463 LEU B CG  1 
ATOM   5777 C CD1 . LEU B 1 432 ? 143.127 104.561 148.312 1.00 36.08  ? 463 LEU B CD1 1 
ATOM   5778 C CD2 . LEU B 1 432 ? 141.783 104.388 146.216 1.00 27.67  ? 463 LEU B CD2 1 
ATOM   5779 N N   . ARG B 1 433 ? 140.715 99.450  149.213 1.00 42.13  ? 464 ARG B N   1 
ATOM   5780 C CA  . ARG B 1 433 ? 140.128 98.176  148.840 1.00 43.40  ? 464 ARG B CA  1 
ATOM   5781 C C   . ARG B 1 433 ? 138.908 98.385  147.950 1.00 42.12  ? 464 ARG B C   1 
ATOM   5782 O O   . ARG B 1 433 ? 138.302 99.457  147.923 1.00 42.17  ? 464 ARG B O   1 
ATOM   5783 C CB  . ARG B 1 433 ? 139.792 97.339  150.074 1.00 46.68  ? 464 ARG B CB  1 
ATOM   5784 C CG  . ARG B 1 433 ? 140.915 97.290  151.098 1.00 51.49  ? 464 ARG B CG  1 
ATOM   5785 C CD  . ARG B 1 433 ? 140.567 96.420  152.295 1.00 60.29  ? 464 ARG B CD  1 
ATOM   5786 N NE  . ARG B 1 433 ? 139.906 97.144  153.373 1.00 72.22  ? 464 ARG B NE  1 
ATOM   5787 C CZ  . ARG B 1 433 ? 140.162 96.953  154.661 1.00 77.19  ? 464 ARG B CZ  1 
ATOM   5788 N NH1 . ARG B 1 433 ? 141.045 96.049  155.061 1.00 79.14  ? 464 ARG B NH1 1 
ATOM   5789 N NH2 . ARG B 1 433 ? 139.509 97.677  155.569 1.00 71.72  ? 464 ARG B NH2 1 
ATOM   5790 N N   . GLU B 1 434 ? 138.562 97.336  147.207 1.00 41.45  ? 465 GLU B N   1 
ATOM   5791 C CA  . GLU B 1 434 ? 137.657 97.423  146.068 1.00 40.79  ? 465 GLU B CA  1 
ATOM   5792 C C   . GLU B 1 434 ? 136.234 97.111  146.498 1.00 42.70  ? 465 GLU B C   1 
ATOM   5793 O O   . GLU B 1 434 ? 136.003 96.168  147.258 1.00 46.54  ? 465 GLU B O   1 
ATOM   5794 C CB  . GLU B 1 434 ? 138.090 96.466  144.959 1.00 42.36  ? 465 GLU B CB  1 
ATOM   5795 C CG  . GLU B 1 434 ? 137.556 96.826  143.587 1.00 43.13  ? 465 GLU B CG  1 
ATOM   5796 C CD  . GLU B 1 434 ? 137.454 95.629  142.669 1.00 43.45  ? 465 GLU B CD  1 
ATOM   5797 O OE1 . GLU B 1 434 ? 137.974 94.551  143.023 1.00 46.95  ? 465 GLU B OE1 1 
ATOM   5798 O OE2 . GLU B 1 434 ? 136.864 95.772  141.582 1.00 41.05  ? 465 GLU B OE2 1 
ATOM   5799 N N   . ILE B 1 435 ? 135.287 97.903  146.003 1.00 40.04  ? 466 ILE B N   1 
ATOM   5800 C CA  . ILE B 1 435 ? 133.872 97.655  146.229 1.00 38.32  ? 466 ILE B CA  1 
ATOM   5801 C C   . ILE B 1 435 ? 133.181 97.084  144.997 1.00 40.04  ? 466 ILE B C   1 
ATOM   5802 O O   . ILE B 1 435 ? 132.581 96.003  145.091 1.00 41.01  ? 466 ILE B O   1 
ATOM   5803 C CB  . ILE B 1 435 ? 133.156 98.943  146.691 1.00 37.17  ? 466 ILE B CB  1 
ATOM   5804 C CG1 . ILE B 1 435 ? 133.780 99.474  147.977 1.00 34.90  ? 466 ILE B CG1 1 
ATOM   5805 C CG2 . ILE B 1 435 ? 131.667 98.706  146.898 1.00 39.95  ? 466 ILE B CG2 1 
ATOM   5806 C CD1 . ILE B 1 435 ? 133.697 98.526  149.151 1.00 36.26  ? 466 ILE B CD1 1 
ATOM   5807 N N   . ALA B 1 436 ? 133.286 97.738  143.846 1.00 38.16  ? 467 ALA B N   1 
ATOM   5808 C CA  . ALA B 1 436 ? 132.478 97.390  142.691 1.00 35.71  ? 467 ALA B CA  1 
ATOM   5809 C C   . ALA B 1 436 ? 133.355 97.310  141.455 1.00 38.65  ? 467 ALA B C   1 
ATOM   5810 O O   . ALA B 1 436 ? 134.515 97.726  141.475 1.00 44.10  ? 467 ALA B O   1 
ATOM   5811 C CB  . ALA B 1 436 ? 131.378 98.417  142.478 1.00 35.53  ? 467 ALA B CB  1 
ATOM   5812 N N   . SER B 1 437 ? 132.776 96.781  140.375 1.00 35.17  ? 468 SER B N   1 
ATOM   5813 C CA  . SER B 1 437 ? 133.428 96.725  139.073 1.00 33.85  ? 468 SER B CA  1 
ATOM   5814 C C   . SER B 1 437 ? 132.368 96.606  137.993 1.00 32.59  ? 468 SER B C   1 
ATOM   5815 O O   . SER B 1 437 ? 131.620 95.629  137.969 1.00 36.58  ? 468 SER B O   1 
ATOM   5816 C CB  . SER B 1 437 ? 134.389 95.536  138.960 1.00 36.25  ? 468 SER B CB  1 
ATOM   5817 O OG  . SER B 1 437 ? 133.698 94.355  138.603 1.00 38.58  ? 468 SER B OG  1 
ATOM   5818 N N   . GLN B 1 438 ? 132.322 97.580  137.088 1.00 30.40  ? 469 GLN B N   1 
ATOM   5819 C CA  . GLN B 1 438 ? 131.428 97.527  135.937 1.00 29.29  ? 469 GLN B CA  1 
ATOM   5820 C C   . GLN B 1 438 ? 132.269 97.438  134.680 1.00 30.02  ? 469 GLN B C   1 
ATOM   5821 O O   . GLN B 1 438 ? 133.086 98.326  134.420 1.00 34.46  ? 469 GLN B O   1 
ATOM   5822 C CB  . GLN B 1 438 ? 130.522 98.752  135.861 1.00 28.55  ? 469 GLN B CB  1 
ATOM   5823 C CG  . GLN B 1 438 ? 129.602 98.738  134.665 1.00 28.60  ? 469 GLN B CG  1 
ATOM   5824 C CD  . GLN B 1 438 ? 128.644 99.900  134.659 1.00 32.58  ? 469 GLN B CD  1 
ATOM   5825 O OE1 . GLN B 1 438 ? 128.788 100.839 135.438 1.00 35.91  ? 469 GLN B OE1 1 
ATOM   5826 N NE2 . GLN B 1 438 ? 127.654 99.846  133.780 1.00 35.35  ? 469 GLN B NE2 1 
ATOM   5827 N N   . ASN B 1 439 ? 132.060 96.385  133.900 1.00 28.07  ? 470 ASN B N   1 
ATOM   5828 C CA  . ASN B 1 439 ? 132.855 96.172  132.701 1.00 25.95  ? 470 ASN B CA  1 
ATOM   5829 C C   . ASN B 1 439 ? 132.379 97.085  131.579 1.00 27.54  ? 470 ASN B C   1 
ATOM   5830 O O   . ASN B 1 439 ? 131.244 97.563  131.588 1.00 30.66  ? 470 ASN B O   1 
ATOM   5831 C CB  . ASN B 1 439 ? 132.772 94.713  132.279 1.00 25.43  ? 470 ASN B CB  1 
ATOM   5832 C CG  . ASN B 1 439 ? 133.954 94.281  131.469 1.00 28.41  ? 470 ASN B CG  1 
ATOM   5833 O OD1 . ASN B 1 439 ? 133.963 94.428  130.254 1.00 30.66  ? 470 ASN B OD1 1 
ATOM   5834 N ND2 . ASN B 1 439 ? 134.968 93.755  132.134 1.00 29.46  ? 470 ASN B ND2 1 
ATOM   5835 N N   . PHE B 1 440 ? 133.266 97.353  130.620 1.00 28.19  ? 471 PHE B N   1 
ATOM   5836 C CA  . PHE B 1 440 ? 132.917 98.259  129.532 1.00 27.66  ? 471 PHE B CA  1 
ATOM   5837 C C   . PHE B 1 440 ? 132.212 97.527  128.396 1.00 25.75  ? 471 PHE B C   1 
ATOM   5838 O O   . PHE B 1 440 ? 131.340 98.099  127.734 1.00 23.65  ? 471 PHE B O   1 
ATOM   5839 C CB  . PHE B 1 440 ? 134.168 98.957  129.004 1.00 25.66  ? 471 PHE B CB  1 
ATOM   5840 C CG  . PHE B 1 440 ? 134.432 100.294 129.625 1.00 20.30  ? 471 PHE B CG  1 
ATOM   5841 C CD1 . PHE B 1 440 ? 134.677 100.404 130.988 1.00 20.07  ? 471 PHE B CD1 1 
ATOM   5842 C CD2 . PHE B 1 440 ? 134.424 101.444 128.840 1.00 20.49  ? 471 PHE B CD2 1 
ATOM   5843 C CE1 . PHE B 1 440 ? 134.929 101.649 131.563 1.00 23.14  ? 471 PHE B CE1 1 
ATOM   5844 C CE2 . PHE B 1 440 ? 134.667 102.693 129.401 1.00 21.45  ? 471 PHE B CE2 1 
ATOM   5845 C CZ  . PHE B 1 440 ? 134.920 102.792 130.765 1.00 21.85  ? 471 PHE B CZ  1 
ATOM   5846 N N   . VAL B 1 441 ? 132.584 96.270  128.147 1.00 26.34  ? 472 VAL B N   1 
ATOM   5847 C CA  . VAL B 1 441 ? 132.100 95.574  126.957 1.00 29.99  ? 472 VAL B CA  1 
ATOM   5848 C C   . VAL B 1 441 ? 130.703 95.022  127.191 1.00 33.75  ? 472 VAL B C   1 
ATOM   5849 O O   . VAL B 1 441 ? 129.740 95.426  126.530 1.00 36.22  ? 472 VAL B O   1 
ATOM   5850 C CB  . VAL B 1 441 ? 133.083 94.464  126.552 1.00 31.14  ? 472 VAL B CB  1 
ATOM   5851 C CG1 . VAL B 1 441 ? 132.579 93.728  125.324 1.00 32.31  ? 472 VAL B CG1 1 
ATOM   5852 C CG2 . VAL B 1 441 ? 134.444 95.054  126.290 1.00 31.07  ? 472 VAL B CG2 1 
ATOM   5853 N N   . THR B 1 442 ? 130.570 94.094  128.130 1.00 33.23  ? 473 THR B N   1 
ATOM   5854 C CA  . THR B 1 442 ? 129.272 93.638  128.607 1.00 32.81  ? 473 THR B CA  1 
ATOM   5855 C C   . THR B 1 442 ? 129.083 94.234  129.987 1.00 30.51  ? 473 THR B C   1 
ATOM   5856 O O   . THR B 1 442 ? 129.793 93.851  130.921 1.00 33.09  ? 473 THR B O   1 
ATOM   5857 C CB  . THR B 1 442 ? 129.201 92.113  128.672 1.00 33.94  ? 473 THR B CB  1 
ATOM   5858 O OG1 . THR B 1 442 ? 130.183 91.632  129.598 1.00 32.87  ? 473 THR B OG1 1 
ATOM   5859 C CG2 . THR B 1 442 ? 129.460 91.505  127.303 1.00 38.54  ? 473 THR B CG2 1 
ATOM   5860 N N   . ASN B 1 443 ? 128.122 95.153  130.129 1.00 27.87  ? 474 ASN B N   1 
ATOM   5861 C CA  . ASN B 1 443 ? 127.978 95.946  131.354 1.00 26.18  ? 474 ASN B CA  1 
ATOM   5862 C C   . ASN B 1 443 ? 127.339 95.114  132.468 1.00 29.08  ? 474 ASN B C   1 
ATOM   5863 O O   . ASN B 1 443 ? 126.164 95.259  132.812 1.00 31.72  ? 474 ASN B O   1 
ATOM   5864 C CB  . ASN B 1 443 ? 127.151 97.196  131.103 1.00 28.62  ? 474 ASN B CB  1 
ATOM   5865 C CG  . ASN B 1 443 ? 127.487 97.885  129.806 1.00 31.62  ? 474 ASN B CG  1 
ATOM   5866 O OD1 . ASN B 1 443 ? 128.557 98.465  129.651 1.00 30.56  ? 474 ASN B OD1 1 
ATOM   5867 N ND2 . ASN B 1 443 ? 126.551 97.836  128.864 1.00 36.68  ? 474 ASN B ND2 1 
ATOM   5868 N N   . VAL B 1 444 ? 128.148 94.242  133.053 1.00 29.68  ? 475 VAL B N   1 
ATOM   5869 C CA  . VAL B 1 444 ? 127.744 93.417  134.176 1.00 31.03  ? 475 VAL B CA  1 
ATOM   5870 C C   . VAL B 1 444 ? 128.443 93.995  135.390 1.00 30.84  ? 475 VAL B C   1 
ATOM   5871 O O   . VAL B 1 444 ? 129.639 93.763  135.595 1.00 30.79  ? 475 VAL B O   1 
ATOM   5872 C CB  . VAL B 1 444 ? 128.109 91.943  133.967 1.00 29.68  ? 475 VAL B CB  1 
ATOM   5873 C CG1 . VAL B 1 444 ? 127.571 91.100  135.105 1.00 27.05  ? 475 VAL B CG1 1 
ATOM   5874 C CG2 . VAL B 1 444 ? 127.573 91.450  132.648 1.00 29.64  ? 475 VAL B CG2 1 
ATOM   5875 N N   . THR B 1 445 ? 127.715 94.791  136.164 1.00 30.62  ? 476 THR B N   1 
ATOM   5876 C CA  . THR B 1 445 ? 128.262 95.333  137.393 1.00 30.91  ? 476 THR B CA  1 
ATOM   5877 C C   . THR B 1 445 ? 128.344 94.236  138.451 1.00 34.54  ? 476 THR B C   1 
ATOM   5878 O O   . THR B 1 445 ? 127.456 93.385  138.563 1.00 37.52  ? 476 THR B O   1 
ATOM   5879 C CB  . THR B 1 445 ? 127.454 96.560  137.847 1.00 30.54  ? 476 THR B CB  1 
ATOM   5880 O OG1 . THR B 1 445 ? 128.047 97.133  139.016 1.00 31.63  ? 476 THR B OG1 1 
ATOM   5881 C CG2 . THR B 1 445 ? 125.955 96.302  138.041 1.00 32.52  ? 476 THR B CG2 1 
ATOM   5882 N N   . THR B 1 446 ? 129.477 94.184  139.137 1.00 34.25  ? 477 THR B N   1 
ATOM   5883 C CA  . THR B 1 446 ? 129.769 93.125  140.090 1.00 35.20  ? 477 THR B CA  1 
ATOM   5884 C C   . THR B 1 446 ? 130.224 93.771  141.384 1.00 37.00  ? 477 THR B C   1 
ATOM   5885 O O   . THR B 1 446 ? 131.219 94.499  141.397 1.00 41.35  ? 477 THR B O   1 
ATOM   5886 C CB  . THR B 1 446 ? 130.839 92.178  139.547 1.00 35.13  ? 477 THR B CB  1 
ATOM   5887 O OG1 . THR B 1 446 ? 130.347 91.534  138.365 1.00 37.00  ? 477 THR B OG1 1 
ATOM   5888 C CG2 . THR B 1 446 ? 131.199 91.125  140.576 1.00 36.57  ? 477 THR B CG2 1 
ATOM   5889 N N   . TYR B 1 447 ? 129.501 93.507  142.462 1.00 36.83  ? 478 TYR B N   1 
ATOM   5890 C CA  . TYR B 1 447 ? 129.771 94.122  143.751 1.00 38.47  ? 478 TYR B CA  1 
ATOM   5891 C C   . TYR B 1 447 ? 130.463 93.112  144.650 1.00 44.95  ? 478 TYR B C   1 
ATOM   5892 O O   . TYR B 1 447 ? 130.040 91.956  144.735 1.00 48.64  ? 478 TYR B O   1 
ATOM   5893 C CB  . TYR B 1 447 ? 128.479 94.630  144.386 1.00 38.25  ? 478 TYR B CB  1 
ATOM   5894 C CG  . TYR B 1 447 ? 127.951 95.874  143.717 1.00 37.12  ? 478 TYR B CG  1 
ATOM   5895 C CD1 . TYR B 1 447 ? 128.350 97.139  144.156 1.00 37.61  ? 478 TYR B CD1 1 
ATOM   5896 C CD2 . TYR B 1 447 ? 127.083 95.784  142.625 1.00 37.80  ? 478 TYR B CD2 1 
ATOM   5897 C CE1 . TYR B 1 447 ? 127.874 98.289  143.537 1.00 38.57  ? 478 TYR B CE1 1 
ATOM   5898 C CE2 . TYR B 1 447 ? 126.613 96.921  141.993 1.00 38.83  ? 478 TYR B CE2 1 
ATOM   5899 C CZ  . TYR B 1 447 ? 127.016 98.163  142.456 1.00 40.04  ? 478 TYR B CZ  1 
ATOM   5900 O OH  . TYR B 1 447 ? 126.543 99.287  141.836 1.00 41.70  ? 478 TYR B OH  1 
ATOM   5901 N N   . TYR B 1 448 ? 131.535 93.549  145.300 1.00 44.09  ? 479 TYR B N   1 
ATOM   5902 C CA  . TYR B 1 448 ? 132.398 92.672  146.076 1.00 46.95  ? 479 TYR B CA  1 
ATOM   5903 C C   . TYR B 1 448 ? 132.126 92.891  147.555 1.00 50.40  ? 479 TYR B C   1 
ATOM   5904 O O   . TYR B 1 448 ? 132.230 94.019  148.048 1.00 50.89  ? 479 TYR B O   1 
ATOM   5905 C CB  . TYR B 1 448 ? 133.868 92.934  145.750 1.00 45.95  ? 479 TYR B CB  1 
ATOM   5906 C CG  . TYR B 1 448 ? 134.216 92.671  144.305 1.00 42.63  ? 479 TYR B CG  1 
ATOM   5907 C CD1 . TYR B 1 448 ? 134.482 91.371  143.864 1.00 43.58  ? 479 TYR B CD1 1 
ATOM   5908 C CD2 . TYR B 1 448 ? 134.273 93.719  143.380 1.00 40.66  ? 479 TYR B CD2 1 
ATOM   5909 C CE1 . TYR B 1 448 ? 134.794 91.117  142.532 1.00 44.60  ? 479 TYR B CE1 1 
ATOM   5910 C CE2 . TYR B 1 448 ? 134.581 93.478  142.047 1.00 42.17  ? 479 TYR B CE2 1 
ATOM   5911 C CZ  . TYR B 1 448 ? 134.841 92.177  141.636 1.00 44.09  ? 479 TYR B CZ  1 
ATOM   5912 O OH  . TYR B 1 448 ? 135.150 91.934  140.319 1.00 47.49  ? 479 TYR B OH  1 
ATOM   5913 N N   . HIS B 1 449 ? 131.780 91.819  148.257 1.00 52.07  ? 480 HIS B N   1 
ATOM   5914 C CA  . HIS B 1 449 ? 131.520 91.865  149.688 1.00 59.33  ? 480 HIS B CA  1 
ATOM   5915 C C   . HIS B 1 449 ? 132.591 91.072  150.421 1.00 64.69  ? 480 HIS B C   1 
ATOM   5916 O O   . HIS B 1 449 ? 132.846 89.910  150.089 1.00 62.79  ? 480 HIS B O   1 
ATOM   5917 C CB  . HIS B 1 449 ? 130.129 91.316  150.012 1.00 57.15  ? 480 HIS B CB  1 
ATOM   5918 C CG  . HIS B 1 449 ? 129.022 92.021  149.292 1.00 55.77  ? 480 HIS B CG  1 
ATOM   5919 N ND1 . HIS B 1 449 ? 128.854 93.388  149.345 1.00 54.46  ? 480 HIS B ND1 1 
ATOM   5920 C CD2 . HIS B 1 449 ? 128.031 91.551  148.499 1.00 56.50  ? 480 HIS B CD2 1 
ATOM   5921 C CE1 . HIS B 1 449 ? 127.807 93.730  148.616 1.00 52.30  ? 480 HIS B CE1 1 
ATOM   5922 N NE2 . HIS B 1 449 ? 127.289 92.634  148.092 1.00 53.45  ? 480 HIS B NE2 1 
ATOM   5923 N N   . TYR B 1 450 ? 133.218 91.708  151.407 1.00 68.44  ? 481 TYR B N   1 
ATOM   5924 C CA  . TYR B 1 450 ? 134.216 91.075  152.258 1.00 72.66  ? 481 TYR B CA  1 
ATOM   5925 C C   . TYR B 1 450 ? 133.543 90.707  153.572 1.00 79.29  ? 481 TYR B C   1 
ATOM   5926 O O   . TYR B 1 450 ? 132.952 91.569  154.229 1.00 78.37  ? 481 TYR B O   1 
ATOM   5927 C CB  . TYR B 1 450 ? 135.399 92.007  152.511 1.00 70.75  ? 481 TYR B CB  1 
ATOM   5928 C CG  . TYR B 1 450 ? 136.000 92.604  151.262 1.00 65.87  ? 481 TYR B CG  1 
ATOM   5929 C CD1 . TYR B 1 450 ? 136.396 91.789  150.194 1.00 64.71  ? 481 TYR B CD1 1 
ATOM   5930 C CD2 . TYR B 1 450 ? 136.186 93.988  151.159 1.00 61.84  ? 481 TYR B CD2 1 
ATOM   5931 C CE1 . TYR B 1 450 ? 136.952 92.342  149.040 1.00 60.86  ? 481 TYR B CE1 1 
ATOM   5932 C CE2 . TYR B 1 450 ? 136.741 94.552  150.016 1.00 58.56  ? 481 TYR B CE2 1 
ATOM   5933 C CZ  . TYR B 1 450 ? 137.121 93.722  148.967 1.00 56.70  ? 481 TYR B CZ  1 
ATOM   5934 O OH  . TYR B 1 450 ? 137.669 94.280  147.836 1.00 51.08  ? 481 TYR B OH  1 
ATOM   5935 N N   . ASN B 1 451 ? 133.637 89.434  153.954 1.00 86.32  ? 482 ASN B N   1 
ATOM   5936 C CA  . ASN B 1 451 ? 132.913 88.914  155.114 1.00 93.63  ? 482 ASN B CA  1 
ATOM   5937 C C   . ASN B 1 451 ? 133.693 89.203  156.396 1.00 96.01  ? 482 ASN B C   1 
ATOM   5938 O O   . ASN B 1 451 ? 134.392 88.352  156.951 1.00 96.40  ? 482 ASN B O   1 
ATOM   5939 C CB  . ASN B 1 451 ? 132.648 87.427  154.939 1.00 99.24  ? 482 ASN B CB  1 
ATOM   5940 C CG  . ASN B 1 451 ? 131.481 86.942  155.770 1.00 103.38 ? 482 ASN B CG  1 
ATOM   5941 O OD1 . ASN B 1 451 ? 130.856 87.716  156.496 1.00 103.39 ? 482 ASN B OD1 1 
ATOM   5942 N ND2 . ASN B 1 451 ? 131.158 85.659  155.642 1.00 103.46 ? 482 ASN B ND2 1 
ATOM   5943 N N   . ARG B 1 452 ? 133.551 90.440  156.872 1.00 98.42  ? 483 ARG B N   1 
ATOM   5944 C CA  . ARG B 1 452 ? 134.151 90.833  158.140 1.00 99.49  ? 483 ARG B CA  1 
ATOM   5945 C C   . ARG B 1 452 ? 133.350 90.269  159.310 1.00 104.55 ? 483 ARG B C   1 
ATOM   5946 O O   . ARG B 1 452 ? 132.164 89.947  159.186 1.00 106.24 ? 483 ARG B O   1 
ATOM   5947 C CB  . ARG B 1 452 ? 134.256 92.356  158.254 1.00 95.10  ? 483 ARG B CB  1 
ATOM   5948 C CG  . ARG B 1 452 ? 134.866 93.046  157.037 1.00 94.43  ? 483 ARG B CG  1 
ATOM   5949 C CD  . ARG B 1 452 ? 135.274 94.476  157.369 1.00 95.50  ? 483 ARG B CD  1 
ATOM   5950 N NE  . ARG B 1 452 ? 136.252 94.492  158.451 1.00 99.69  ? 483 ARG B NE  1 
ATOM   5951 C CZ  . ARG B 1 452 ? 136.937 95.559  158.844 1.00 94.62  ? 483 ARG B CZ  1 
ATOM   5952 N NH1 . ARG B 1 452 ? 136.807 96.727  158.238 1.00 94.27  ? 483 ARG B NH1 1 
ATOM   5953 N NH2 . ARG B 1 452 ? 137.769 95.450  159.876 1.00 90.49  ? 483 ARG B NH2 1 
ATOM   5954 N N   . ASP B 1 453 ? 134.045 90.089  160.439 1.00 106.86 ? 484 ASP B N   1 
ATOM   5955 C CA  . ASP B 1 453 ? 133.601 89.568  161.734 1.00 108.31 ? 484 ASP B CA  1 
ATOM   5956 C C   . ASP B 1 453 ? 133.036 88.134  161.674 1.00 108.51 ? 484 ASP B C   1 
ATOM   5957 O O   . ASP B 1 453 ? 132.258 87.773  162.567 1.00 110.52 ? 484 ASP B O   1 
ATOM   5958 C CB  . ASP B 1 453 ? 132.577 90.479  162.448 1.00 109.93 ? 484 ASP B CB  1 
ATOM   5959 C CG  . ASP B 1 453 ? 133.182 91.800  162.906 1.00 110.39 ? 484 ASP B CG  1 
ATOM   5960 O OD1 . ASP B 1 453 ? 134.398 91.829  163.196 1.00 106.85 ? 484 ASP B OD1 1 
ATOM   5961 O OD2 . ASP B 1 453 ? 132.450 92.814  162.967 1.00 112.99 ? 484 ASP B OD2 1 
ATOM   5962 N N   . ASN B 1 454 ? 133.376 87.330  160.641 1.00 101.74 ? 485 ASN B N   1 
ATOM   5963 C CA  . ASN B 1 454 ? 133.212 85.873  160.507 1.00 99.70  ? 485 ASN B CA  1 
ATOM   5964 C C   . ASN B 1 454 ? 131.759 85.416  160.540 1.00 103.17 ? 485 ASN B C   1 
ATOM   5965 O O   . ASN B 1 454 ? 131.386 84.598  161.390 1.00 101.64 ? 485 ASN B O   1 
ATOM   5966 C CB  . ASN B 1 454 ? 133.995 85.121  161.590 1.00 97.11  ? 485 ASN B CB  1 
ATOM   5967 C CG  . ASN B 1 454 ? 135.476 85.301  161.456 1.00 93.80  ? 485 ASN B CG  1 
ATOM   5968 O OD1 . ASN B 1 454 ? 135.945 86.077  160.621 1.00 92.16  ? 485 ASN B OD1 1 
ATOM   5969 N ND2 . ASN B 1 454 ? 136.226 84.650  162.333 1.00 92.35  ? 485 ASN B ND2 1 
ATOM   5970 N N   . HIS B 1 455 ? 130.916 85.935  159.656 1.00 108.74 ? 486 HIS B N   1 
ATOM   5971 C CA  . HIS B 1 455 ? 129.540 85.464  159.611 1.00 112.51 ? 486 HIS B CA  1 
ATOM   5972 C C   . HIS B 1 455 ? 129.363 84.410  158.519 1.00 114.37 ? 486 HIS B C   1 
ATOM   5973 O O   . HIS B 1 455 ? 130.006 84.451  157.465 1.00 112.49 ? 486 HIS B O   1 
ATOM   5974 C CB  . HIS B 1 455 ? 128.586 86.635  159.397 1.00 108.89 ? 486 HIS B CB  1 
ATOM   5975 C CG  . HIS B 1 455 ? 128.684 87.691  160.454 1.00 111.48 ? 486 HIS B CG  1 
ATOM   5976 N ND1 . HIS B 1 455 ? 128.377 89.012  160.214 1.00 114.06 ? 486 HIS B ND1 1 
ATOM   5977 C CD2 . HIS B 1 455 ? 129.068 87.625  161.752 1.00 112.45 ? 486 HIS B CD2 1 
ATOM   5978 C CE1 . HIS B 1 455 ? 128.558 89.713  161.319 1.00 113.10 ? 486 HIS B CE1 1 
ATOM   5979 N NE2 . HIS B 1 455 ? 128.978 88.895  162.268 1.00 111.26 ? 486 HIS B NE2 1 
ATOM   5980 N N   . THR B 1 456 ? 128.478 83.451  158.782 1.00 115.14 ? 487 THR B N   1 
ATOM   5981 C CA  . THR B 1 456 ? 128.188 82.380  157.840 1.00 118.40 ? 487 THR B CA  1 
ATOM   5982 C C   . THR B 1 456 ? 127.010 82.712  156.931 1.00 120.48 ? 487 THR B C   1 
ATOM   5983 O O   . THR B 1 456 ? 126.673 81.918  156.046 1.00 118.67 ? 487 THR B O   1 
ATOM   5984 C CB  . THR B 1 456 ? 127.930 81.070  158.587 1.00 119.65 ? 487 THR B CB  1 
ATOM   5985 O OG1 . THR B 1 456 ? 126.594 81.065  159.107 1.00 119.42 ? 487 THR B OG1 1 
ATOM   5986 C CG2 . THR B 1 456 ? 128.925 80.896  159.733 1.00 116.00 ? 487 THR B CG2 1 
ATOM   5987 N N   . SER B 1 457 ? 126.387 83.872  157.124 1.00 119.61 ? 488 SER B N   1 
ATOM   5988 C CA  . SER B 1 457 ? 125.294 84.314  156.270 1.00 114.55 ? 488 SER B CA  1 
ATOM   5989 C C   . SER B 1 457 ? 125.294 85.834  156.236 1.00 109.77 ? 488 SER B C   1 
ATOM   5990 O O   . SER B 1 457 ? 125.659 86.497  157.211 1.00 107.87 ? 488 SER B O   1 
ATOM   5991 C CB  . SER B 1 457 ? 123.940 83.781  156.757 1.00 111.44 ? 488 SER B CB  1 
ATOM   5992 O OG  . SER B 1 457 ? 123.620 84.288  158.041 1.00 111.63 ? 488 SER B OG  1 
ATOM   5993 N N   . LEU B 1 458 ? 124.885 86.377  155.093 1.00 103.62 ? 489 LEU B N   1 
ATOM   5994 C CA  . LEU B 1 458 ? 124.831 87.814  154.879 1.00 96.06  ? 489 LEU B CA  1 
ATOM   5995 C C   . LEU B 1 458 ? 123.447 88.173  154.359 1.00 90.80  ? 489 LEU B C   1 
ATOM   5996 O O   . LEU B 1 458 ? 123.025 87.675  153.311 1.00 91.71  ? 489 LEU B O   1 
ATOM   5997 C CB  . LEU B 1 458 ? 125.938 88.257  153.907 1.00 94.24  ? 489 LEU B CB  1 
ATOM   5998 C CG  . LEU B 1 458 ? 126.306 89.725  153.649 1.00 89.97  ? 489 LEU B CG  1 
ATOM   5999 C CD1 . LEU B 1 458 ? 127.793 89.800  153.370 1.00 88.60  ? 489 LEU B CD1 1 
ATOM   6000 C CD2 . LEU B 1 458 ? 125.569 90.344  152.468 1.00 84.95  ? 489 LEU B CD2 1 
ATOM   6001 N N   . GLU B 1 459 ? 122.750 89.025  155.101 1.00 85.35  ? 490 GLU B N   1 
ATOM   6002 C CA  . GLU B 1 459 ? 121.463 89.573  154.689 1.00 80.05  ? 490 GLU B CA  1 
ATOM   6003 C C   . GLU B 1 459 ? 121.711 90.577  153.570 1.00 76.49  ? 490 GLU B C   1 
ATOM   6004 O O   . GLU B 1 459 ? 122.588 91.438  153.683 1.00 76.27  ? 490 GLU B O   1 
ATOM   6005 C CB  . GLU B 1 459 ? 120.773 90.224  155.884 1.00 83.19  ? 490 GLU B CB  1 
ATOM   6006 C CG  . GLU B 1 459 ? 119.428 90.867  155.602 1.00 84.44  ? 490 GLU B CG  1 
ATOM   6007 C CD  . GLU B 1 459 ? 118.799 91.459  156.854 1.00 86.75  ? 490 GLU B CD  1 
ATOM   6008 O OE1 . GLU B 1 459 ? 119.438 91.405  157.926 1.00 86.13  ? 490 GLU B OE1 1 
ATOM   6009 O OE2 . GLU B 1 459 ? 117.671 91.986  156.764 1.00 86.68  ? 490 GLU B OE2 1 
ATOM   6010 N N   . LEU B 1 460 ? 120.953 90.461  152.486 1.00 75.33  ? 491 LEU B N   1 
ATOM   6011 C CA  . LEU B 1 460 ? 121.131 91.360  151.355 1.00 72.20  ? 491 LEU B CA  1 
ATOM   6012 C C   . LEU B 1 460 ? 120.479 92.704  151.646 1.00 63.82  ? 491 LEU B C   1 
ATOM   6013 O O   . LEU B 1 460 ? 119.279 92.776  151.925 1.00 63.93  ? 491 LEU B O   1 
ATOM   6014 C CB  . LEU B 1 460 ? 120.531 90.747  150.087 1.00 74.08  ? 491 LEU B CB  1 
ATOM   6015 C CG  . LEU B 1 460 ? 121.214 89.542  149.429 1.00 74.53  ? 491 LEU B CG  1 
ATOM   6016 C CD1 . LEU B 1 460 ? 120.622 89.298  148.052 1.00 72.42  ? 491 LEU B CD1 1 
ATOM   6017 C CD2 . LEU B 1 460 ? 122.724 89.727  149.334 1.00 71.09  ? 491 LEU B CD2 1 
ATOM   6018 N N   . LYS B 1 461 ? 121.270 93.765  151.589 1.00 57.22  ? 492 LYS B N   1 
ATOM   6019 C CA  . LYS B 1 461 ? 120.770 95.107  151.830 1.00 52.09  ? 492 LYS B CA  1 
ATOM   6020 C C   . LYS B 1 461 ? 120.002 95.618  150.621 1.00 43.18  ? 492 LYS B C   1 
ATOM   6021 O O   . LYS B 1 461 ? 120.161 95.128  149.502 1.00 42.72  ? 492 LYS B O   1 
ATOM   6022 C CB  . LYS B 1 461 ? 121.910 96.073  152.167 1.00 53.31  ? 492 LYS B CB  1 
ATOM   6023 C CG  . LYS B 1 461 ? 122.616 95.782  153.475 1.00 51.45  ? 492 LYS B CG  1 
ATOM   6024 C CD  . LYS B 1 461 ? 123.607 96.874  153.805 1.00 50.29  ? 492 LYS B CD  1 
ATOM   6025 C CE  . LYS B 1 461 ? 124.386 96.537  155.062 1.00 56.69  ? 492 LYS B CE  1 
ATOM   6026 N NZ  . LYS B 1 461 ? 125.287 97.650  155.475 1.00 58.81  ? 492 LYS B NZ  1 
ATOM   6027 N N   . THR B 1 462 ? 119.146 96.602  150.875 1.00 37.99  ? 493 THR B N   1 
ATOM   6028 C CA  . THR B 1 462 ? 118.418 97.271  149.809 1.00 32.79  ? 493 THR B CA  1 
ATOM   6029 C C   . THR B 1 462 ? 119.360 98.167  149.025 1.00 28.80  ? 493 THR B C   1 
ATOM   6030 O O   . THR B 1 462 ? 120.306 98.727  149.578 1.00 29.67  ? 493 THR B O   1 
ATOM   6031 C CB  . THR B 1 462 ? 117.275 98.100  150.384 1.00 33.03  ? 493 THR B CB  1 
ATOM   6032 O OG1 . THR B 1 462 ? 117.813 99.204  151.119 1.00 34.49  ? 493 THR B OG1 1 
ATOM   6033 C CG2 . THR B 1 462 ? 116.429 97.252  151.319 1.00 33.33  ? 493 THR B CG2 1 
ATOM   6034 N N   . LYS B 1 463 ? 119.106 98.289  147.728 1.00 26.93  ? 494 LYS B N   1 
ATOM   6035 C CA  . LYS B 1 463 ? 120.020 99.017  146.868 1.00 24.46  ? 494 LYS B CA  1 
ATOM   6036 C C   . LYS B 1 463 ? 119.805 100.520 146.993 1.00 20.77  ? 494 LYS B C   1 
ATOM   6037 O O   . LYS B 1 463 ? 118.827 100.985 147.571 1.00 23.47  ? 494 LYS B O   1 
ATOM   6038 C CB  . LYS B 1 463 ? 119.863 98.564  145.421 1.00 24.30  ? 494 LYS B CB  1 
ATOM   6039 C CG  . LYS B 1 463 ? 120.055 97.072  145.250 1.00 25.38  ? 494 LYS B CG  1 
ATOM   6040 C CD  . LYS B 1 463 ? 119.988 96.659  143.800 1.00 31.00  ? 494 LYS B CD  1 
ATOM   6041 C CE  . LYS B 1 463 ? 120.618 95.291  143.602 1.00 33.88  ? 494 LYS B CE  1 
ATOM   6042 N NZ  . LYS B 1 463 ? 120.679 94.904  142.166 1.00 27.62  ? 494 LYS B NZ  1 
ATOM   6043 N N   . PHE B 1 464 ? 120.760 101.280 146.458 1.00 16.75  ? 495 PHE B N   1 
ATOM   6044 C CA  . PHE B 1 464 ? 120.705 102.739 146.525 1.00 17.40  ? 495 PHE B CA  1 
ATOM   6045 C C   . PHE B 1 464 ? 119.682 103.284 145.538 1.00 21.03  ? 495 PHE B C   1 
ATOM   6046 O O   . PHE B 1 464 ? 119.147 104.378 145.735 1.00 23.39  ? 495 PHE B O   1 
ATOM   6047 C CB  . PHE B 1 464 ? 122.120 103.280 146.274 1.00 15.94  ? 495 PHE B CB  1 
ATOM   6048 C CG  . PHE B 1 464 ? 122.278 104.791 146.191 1.00 14.14  ? 495 PHE B CG  1 
ATOM   6049 C CD1 . PHE B 1 464 ? 122.243 105.468 144.958 1.00 15.24  ? 495 PHE B CD1 1 
ATOM   6050 C CD2 . PHE B 1 464 ? 122.631 105.507 147.328 1.00 16.44  ? 495 PHE B CD2 1 
ATOM   6051 C CE1 . PHE B 1 464 ? 122.439 106.840 144.887 1.00 15.54  ? 495 PHE B CE1 1 
ATOM   6052 C CE2 . PHE B 1 464 ? 122.853 106.887 147.265 1.00 17.53  ? 495 PHE B CE2 1 
ATOM   6053 C CZ  . PHE B 1 464 ? 122.750 107.547 146.041 1.00 17.15  ? 495 PHE B CZ  1 
ATOM   6054 N N   . GLY B 1 465 ? 119.418 102.552 144.456 1.00 21.46  ? 496 GLY B N   1 
ATOM   6055 C CA  . GLY B 1 465 ? 118.462 103.032 143.473 1.00 20.16  ? 496 GLY B CA  1 
ATOM   6056 C C   . GLY B 1 465 ? 117.025 102.852 143.920 1.00 21.98  ? 496 GLY B C   1 
ATOM   6057 O O   . GLY B 1 465 ? 116.144 103.625 143.539 1.00 25.13  ? 496 GLY B O   1 
ATOM   6058 N N   . GLN B 1 466 ? 116.769 101.827 144.733 1.00 21.23  ? 497 GLN B N   1 
ATOM   6059 C CA  . GLN B 1 466 ? 115.422 101.615 145.249 1.00 22.13  ? 497 GLN B CA  1 
ATOM   6060 C C   . GLN B 1 466 ? 115.113 102.557 146.406 1.00 22.99  ? 497 GLN B C   1 
ATOM   6061 O O   . GLN B 1 466 ? 113.943 102.807 146.715 1.00 25.15  ? 497 GLN B O   1 
ATOM   6062 C CB  . GLN B 1 466 ? 115.244 100.161 145.671 1.00 22.48  ? 497 GLN B CB  1 
ATOM   6063 C CG  . GLN B 1 466 ? 115.447 99.178  144.541 1.00 25.50  ? 497 GLN B CG  1 
ATOM   6064 C CD  . GLN B 1 466 ? 115.433 97.740  145.010 1.00 29.81  ? 497 GLN B CD  1 
ATOM   6065 O OE1 . GLN B 1 466 ? 115.192 97.460  146.182 1.00 27.72  ? 497 GLN B OE1 1 
ATOM   6066 N NE2 . GLN B 1 466 ? 115.685 96.817  144.090 1.00 35.85  ? 497 GLN B NE2 1 
ATOM   6067 N N   . VAL B 1 467 ? 116.145 103.079 147.066 1.00 22.65  ? 498 VAL B N   1 
ATOM   6068 C CA  . VAL B 1 467 ? 115.924 104.079 148.104 1.00 22.51  ? 498 VAL B CA  1 
ATOM   6069 C C   . VAL B 1 467 ? 115.765 105.463 147.482 1.00 22.29  ? 498 VAL B C   1 
ATOM   6070 O O   . VAL B 1 467 ? 114.833 106.205 147.812 1.00 24.12  ? 498 VAL B O   1 
ATOM   6071 C CB  . VAL B 1 467 ? 117.065 104.021 149.140 1.00 20.83  ? 498 VAL B CB  1 
ATOM   6072 C CG1 . VAL B 1 467 ? 116.936 105.112 150.178 1.00 22.87  ? 498 VAL B CG1 1 
ATOM   6073 C CG2 . VAL B 1 467 ? 117.044 102.687 149.854 1.00 22.48  ? 498 VAL B CG2 1 
ATOM   6074 N N   . PHE B 1 468 ? 116.620 105.805 146.522 1.00 21.96  ? 499 PHE B N   1 
ATOM   6075 C CA  . PHE B 1 468 ? 116.725 107.171 146.022 1.00 23.84  ? 499 PHE B CA  1 
ATOM   6076 C C   . PHE B 1 468 ? 115.965 107.374 144.714 1.00 27.66  ? 499 PHE B C   1 
ATOM   6077 O O   . PHE B 1 468 ? 116.414 108.124 143.844 1.00 29.01  ? 499 PHE B O   1 
ATOM   6078 C CB  . PHE B 1 468 ? 118.185 107.586 145.835 1.00 19.90  ? 499 PHE B CB  1 
ATOM   6079 C CG  . PHE B 1 468 ? 118.894 107.966 147.108 1.00 20.44  ? 499 PHE B CG  1 
ATOM   6080 C CD1 . PHE B 1 468 ? 119.285 106.995 148.041 1.00 21.44  ? 499 PHE B CD1 1 
ATOM   6081 C CD2 . PHE B 1 468 ? 119.188 109.301 147.361 1.00 21.75  ? 499 PHE B CD2 1 
ATOM   6082 C CE1 . PHE B 1 468 ? 119.932 107.354 149.215 1.00 21.97  ? 499 PHE B CE1 1 
ATOM   6083 C CE2 . PHE B 1 468 ? 119.844 109.670 148.527 1.00 21.50  ? 499 PHE B CE2 1 
ATOM   6084 C CZ  . PHE B 1 468 ? 120.224 108.691 149.447 1.00 20.76  ? 499 PHE B CZ  1 
ATOM   6085 N N   . ASN B 1 469 ? 114.816 106.723 144.557 1.00 27.88  ? 500 ASN B N   1 
ATOM   6086 C CA  . ASN B 1 469 ? 113.985 106.929 143.378 1.00 28.21  ? 500 ASN B CA  1 
ATOM   6087 C C   . ASN B 1 469 ? 113.047 108.115 143.611 1.00 32.28  ? 500 ASN B C   1 
ATOM   6088 O O   . ASN B 1 469 ? 113.172 108.869 144.580 1.00 32.60  ? 500 ASN B O   1 
ATOM   6089 C CB  . ASN B 1 469 ? 113.224 105.654 143.021 1.00 25.77  ? 500 ASN B CB  1 
ATOM   6090 C CG  . ASN B 1 469 ? 112.599 104.970 144.227 1.00 27.92  ? 500 ASN B CG  1 
ATOM   6091 O OD1 . ASN B 1 469 ? 112.581 105.502 145.334 1.00 31.22  ? 500 ASN B OD1 1 
ATOM   6092 N ND2 . ASN B 1 469 ? 112.065 103.777 144.005 1.00 25.98  ? 500 ASN B ND2 1 
ATOM   6093 N N   . CYS B 1 470 ? 112.084 108.291 142.716 1.00 35.88  ? 501 CYS B N   1 
ATOM   6094 C CA  . CYS B 1 470 ? 111.122 109.375 142.862 1.00 38.04  ? 501 CYS B CA  1 
ATOM   6095 C C   . CYS B 1 470 ? 109.786 108.855 143.385 1.00 33.52  ? 501 CYS B C   1 
ATOM   6096 O O   . CYS B 1 470 ? 108.978 108.318 142.630 1.00 35.36  ? 501 CYS B O   1 
ATOM   6097 C CB  . CYS B 1 470 ? 110.928 110.092 141.531 1.00 39.93  ? 501 CYS B CB  1 
ATOM   6098 S SG  . CYS B 1 470 ? 112.464 110.659 140.771 1.00 52.68  ? 501 CYS B SG  1 
ATOM   6099 N N   . MET B 1 490 ? 111.092 121.774 141.671 1.00 66.13  ? 521 MET B N   1 
ATOM   6100 C CA  . MET B 1 490 ? 112.493 121.427 141.868 1.00 63.21  ? 521 MET B CA  1 
ATOM   6101 C C   . MET B 1 490 ? 113.388 122.616 141.563 1.00 59.94  ? 521 MET B C   1 
ATOM   6102 O O   . MET B 1 490 ? 113.451 123.080 140.428 1.00 58.63  ? 521 MET B O   1 
ATOM   6103 C CB  . MET B 1 490 ? 112.877 120.233 140.993 1.00 61.92  ? 521 MET B CB  1 
ATOM   6104 C CG  . MET B 1 490 ? 112.197 118.934 141.395 1.00 68.42  ? 521 MET B CG  1 
ATOM   6105 S SD  . MET B 1 490 ? 112.651 117.539 140.348 1.00 91.88  ? 521 MET B SD  1 
ATOM   6106 C CE  . MET B 1 490 ? 111.617 116.247 141.034 1.00 77.23  ? 521 MET B CE  1 
ATOM   6107 N N   . PHE B 1 491 ? 114.074 123.117 142.585 1.00 58.52  ? 522 PHE B N   1 
ATOM   6108 C CA  . PHE B 1 491 ? 114.971 124.244 142.385 1.00 55.71  ? 522 PHE B CA  1 
ATOM   6109 C C   . PHE B 1 491 ? 116.372 123.927 142.897 1.00 55.32  ? 522 PHE B C   1 
ATOM   6110 O O   . PHE B 1 491 ? 116.550 123.181 143.861 1.00 59.25  ? 522 PHE B O   1 
ATOM   6111 C CB  . PHE B 1 491 ? 114.406 125.520 143.032 1.00 56.46  ? 522 PHE B CB  1 
ATOM   6112 C CG  . PHE B 1 491 ? 114.371 125.530 144.546 1.00 53.74  ? 522 PHE B CG  1 
ATOM   6113 C CD1 . PHE B 1 491 ? 113.311 124.941 145.239 1.00 52.94  ? 522 PHE B CD1 1 
ATOM   6114 C CD2 . PHE B 1 491 ? 115.346 126.223 145.270 1.00 54.66  ? 522 PHE B CD2 1 
ATOM   6115 C CE1 . PHE B 1 491 ? 113.257 124.979 146.628 1.00 53.87  ? 522 PHE B CE1 1 
ATOM   6116 C CE2 . PHE B 1 491 ? 115.306 126.266 146.660 1.00 55.49  ? 522 PHE B CE2 1 
ATOM   6117 C CZ  . PHE B 1 491 ? 114.256 125.643 147.335 1.00 55.08  ? 522 PHE B CZ  1 
ATOM   6118 N N   . TRP B 1 492 ? 117.364 124.519 142.244 1.00 53.65  ? 523 TRP B N   1 
ATOM   6119 C CA  . TRP B 1 492 ? 118.774 124.243 142.470 1.00 53.26  ? 523 TRP B CA  1 
ATOM   6120 C C   . TRP B 1 492 ? 119.415 125.401 143.219 1.00 53.91  ? 523 TRP B C   1 
ATOM   6121 O O   . TRP B 1 492 ? 119.340 126.542 142.765 1.00 57.21  ? 523 TRP B O   1 
ATOM   6122 C CB  . TRP B 1 492 ? 119.483 124.046 141.129 1.00 50.69  ? 523 TRP B CB  1 
ATOM   6123 C CG  . TRP B 1 492 ? 119.227 122.743 140.435 1.00 53.34  ? 523 TRP B CG  1 
ATOM   6124 C CD1 . TRP B 1 492 ? 119.914 121.585 140.612 1.00 56.92  ? 523 TRP B CD1 1 
ATOM   6125 C CD2 . TRP B 1 492 ? 118.181 122.446 139.503 1.00 54.35  ? 523 TRP B CD2 1 
ATOM   6126 N NE1 . TRP B 1 492 ? 119.413 120.601 139.807 1.00 57.97  ? 523 TRP B NE1 1 
ATOM   6127 C CE2 . TRP B 1 492 ? 118.333 121.095 139.129 1.00 58.41  ? 523 TRP B CE2 1 
ATOM   6128 C CE3 . TRP B 1 492 ? 117.148 123.193 138.930 1.00 53.37  ? 523 TRP B CE3 1 
ATOM   6129 C CZ2 . TRP B 1 492 ? 117.483 120.472 138.216 1.00 59.27  ? 523 TRP B CZ2 1 
ATOM   6130 C CZ3 . TRP B 1 492 ? 116.303 122.569 138.020 1.00 55.63  ? 523 TRP B CZ3 1 
ATOM   6131 C CH2 . TRP B 1 492 ? 116.478 121.224 137.674 1.00 58.49  ? 523 TRP B CH2 1 
ATOM   6132 N N   . ARG B 1 493 ? 120.066 125.107 144.343 1.00 49.64  ? 524 ARG B N   1 
ATOM   6133 C CA  . ARG B 1 493 ? 120.804 126.107 145.110 1.00 47.72  ? 524 ARG B CA  1 
ATOM   6134 C C   . ARG B 1 493 ? 122.296 125.889 144.893 1.00 46.95  ? 524 ARG B C   1 
ATOM   6135 O O   . ARG B 1 493 ? 122.825 124.834 145.249 1.00 52.13  ? 524 ARG B O   1 
ATOM   6136 C CB  . ARG B 1 493 ? 120.467 126.011 146.596 1.00 49.37  ? 524 ARG B CB  1 
ATOM   6137 C CG  . ARG B 1 493 ? 118.993 125.868 146.897 1.00 51.92  ? 524 ARG B CG  1 
ATOM   6138 C CD  . ARG B 1 493 ? 118.776 125.589 148.368 1.00 56.78  ? 524 ARG B CD  1 
ATOM   6139 N NE  . ARG B 1 493 ? 119.208 126.709 149.193 1.00 60.79  ? 524 ARG B NE  1 
ATOM   6140 C CZ  . ARG B 1 493 ? 119.108 126.751 150.513 1.00 61.05  ? 524 ARG B CZ  1 
ATOM   6141 N NH1 . ARG B 1 493 ? 118.604 125.741 151.200 1.00 63.67  ? 524 ARG B NH1 1 
ATOM   6142 N NH2 . ARG B 1 493 ? 119.525 127.833 151.161 1.00 59.28  ? 524 ARG B NH2 1 
ATOM   6143 N N   . ILE B 1 494 ? 122.979 126.886 144.337 1.00 41.71  ? 525 ILE B N   1 
ATOM   6144 C CA  . ILE B 1 494 ? 124.337 126.711 143.829 1.00 40.82  ? 525 ILE B CA  1 
ATOM   6145 C C   . ILE B 1 494 ? 125.270 127.635 144.604 1.00 42.74  ? 525 ILE B C   1 
ATOM   6146 O O   . ILE B 1 494 ? 125.051 128.850 144.644 1.00 45.85  ? 525 ILE B O   1 
ATOM   6147 C CB  . ILE B 1 494 ? 124.442 126.990 142.318 1.00 42.07  ? 525 ILE B CB  1 
ATOM   6148 C CG1 . ILE B 1 494 ? 123.516 126.107 141.479 1.00 44.62  ? 525 ILE B CG1 1 
ATOM   6149 C CG2 . ILE B 1 494 ? 125.813 126.666 141.830 1.00 41.89  ? 525 ILE B CG2 1 
ATOM   6150 C CD1 . ILE B 1 494 ? 122.235 126.753 141.004 1.00 45.03  ? 525 ILE B CD1 1 
ATOM   6151 N N   . LYS B 1 495 ? 126.317 127.065 145.201 1.00 42.51  ? 526 LYS B N   1 
ATOM   6152 C CA  . LYS B 1 495 ? 127.316 127.819 145.945 1.00 43.14  ? 526 LYS B CA  1 
ATOM   6153 C C   . LYS B 1 495 ? 128.674 127.685 145.271 1.00 45.05  ? 526 LYS B C   1 
ATOM   6154 O O   . LYS B 1 495 ? 129.209 126.578 145.172 1.00 44.13  ? 526 LYS B O   1 
ATOM   6155 C CB  . LYS B 1 495 ? 127.408 127.316 147.383 1.00 41.12  ? 526 LYS B CB  1 
ATOM   6156 C CG  . LYS B 1 495 ? 126.086 127.312 148.102 1.00 40.69  ? 526 LYS B CG  1 
ATOM   6157 C CD  . LYS B 1 495 ? 126.198 126.744 149.497 1.00 41.36  ? 526 LYS B CD  1 
ATOM   6158 C CE  . LYS B 1 495 ? 126.227 125.234 149.467 1.00 40.17  ? 526 LYS B CE  1 
ATOM   6159 N NZ  . LYS B 1 495 ? 126.139 124.655 150.834 1.00 38.09  ? 526 LYS B NZ  1 
ATOM   6160 N N   . MET B 1 496 ? 129.234 128.806 144.825 1.00 47.20  ? 527 MET B N   1 
ATOM   6161 C CA  . MET B 1 496 ? 130.596 128.863 144.308 1.00 45.23  ? 527 MET B CA  1 
ATOM   6162 C C   . MET B 1 496 ? 131.573 128.970 145.464 1.00 46.18  ? 527 MET B C   1 
ATOM   6163 O O   . MET B 1 496 ? 131.491 129.904 146.265 1.00 51.93  ? 527 MET B O   1 
ATOM   6164 C CB  . MET B 1 496 ? 130.779 130.034 143.349 1.00 49.61  ? 527 MET B CB  1 
ATOM   6165 C CG  . MET B 1 496 ? 131.619 129.692 142.148 1.00 52.82  ? 527 MET B CG  1 
ATOM   6166 S SD  . MET B 1 496 ? 131.724 131.013 140.931 1.00 76.52  ? 527 MET B SD  1 
ATOM   6167 C CE  . MET B 1 496 ? 132.901 132.117 141.683 1.00 57.15  ? 527 MET B CE  1 
ATOM   6168 N N   . ASP B 1 497 ? 132.506 128.030 145.531 1.00 44.84  ? 528 ASP B N   1 
ATOM   6169 C CA  . ASP B 1 497 ? 133.443 127.935 146.635 1.00 48.19  ? 528 ASP B CA  1 
ATOM   6170 C C   . ASP B 1 497 ? 134.845 127.693 146.096 1.00 52.55  ? 528 ASP B C   1 
ATOM   6171 O O   . ASP B 1 497 ? 135.022 127.275 144.950 1.00 56.37  ? 528 ASP B O   1 
ATOM   6172 C CB  . ASP B 1 497 ? 133.036 126.810 147.598 1.00 50.48  ? 528 ASP B CB  1 
ATOM   6173 C CG  . ASP B 1 497 ? 133.515 127.049 149.015 1.00 52.28  ? 528 ASP B CG  1 
ATOM   6174 O OD1 . ASP B 1 497 ? 134.195 128.069 149.246 1.00 51.31  ? 528 ASP B OD1 1 
ATOM   6175 O OD2 . ASP B 1 497 ? 133.212 126.221 149.899 1.00 53.03  ? 528 ASP B OD2 1 
ATOM   6176 N N   . THR B 1 498 ? 135.841 127.995 146.921 1.00 52.06  ? 529 THR B N   1 
ATOM   6177 C CA  . THR B 1 498 ? 137.233 127.692 146.606 1.00 51.70  ? 529 THR B CA  1 
ATOM   6178 C C   . THR B 1 498 ? 138.000 127.297 147.865 1.00 50.22  ? 529 THR B C   1 
ATOM   6179 O O   . THR B 1 498 ? 137.817 127.889 148.929 1.00 51.19  ? 529 THR B O   1 
ATOM   6180 C CB  . THR B 1 498 ? 137.944 128.879 145.941 1.00 50.41  ? 529 THR B CB  1 
ATOM   6181 O OG1 . THR B 1 498 ? 137.284 129.217 144.718 1.00 47.07  ? 529 THR B OG1 1 
ATOM   6182 C CG2 . THR B 1 498 ? 139.385 128.532 145.644 1.00 53.11  ? 529 THR B CG2 1 
HETATM 6183 C C1  . NAG C 2 .   ? 100.012 120.983 132.702 1.00 104.35 ? 601 NAG A C1  1 
HETATM 6184 C C2  . NAG C 2 .   ? 99.014  120.847 133.882 1.00 103.88 ? 601 NAG A C2  1 
HETATM 6185 C C3  . NAG C 2 .   ? 99.208  119.483 134.587 1.00 103.65 ? 601 NAG A C3  1 
HETATM 6186 C C4  . NAG C 2 .   ? 99.271  118.262 133.651 1.00 104.95 ? 601 NAG A C4  1 
HETATM 6187 C C5  . NAG C 2 .   ? 100.279 118.536 132.513 1.00 104.03 ? 601 NAG A C5  1 
HETATM 6188 C C6  . NAG C 2 .   ? 100.308 117.458 131.452 1.00 103.12 ? 601 NAG A C6  1 
HETATM 6189 C C7  . NAG C 2 .   ? 100.007 122.463 135.592 1.00 102.00 ? 601 NAG A C7  1 
HETATM 6190 C C8  . NAG C 2 .   ? 99.581  123.669 136.391 1.00 96.35  ? 601 NAG A C8  1 
HETATM 6191 N N2  . NAG C 2 .   ? 99.028  121.972 134.795 1.00 102.85 ? 601 NAG A N2  1 
HETATM 6192 O O3  . NAG C 2 .   ? 98.177  119.343 135.528 1.00 101.37 ? 601 NAG A O3  1 
HETATM 6193 O O4  . NAG C 2 .   ? 99.636  117.148 134.432 1.00 106.75 ? 601 NAG A O4  1 
HETATM 6194 O O5  . NAG C 2 .   ? 99.968  119.797 131.907 1.00 104.10 ? 601 NAG A O5  1 
HETATM 6195 O O6  . NAG C 2 .   ? 100.768 116.252 132.013 1.00 103.29 ? 601 NAG A O6  1 
HETATM 6196 O O7  . NAG C 2 .   ? 101.144 122.023 135.707 1.00 103.54 ? 601 NAG A O7  1 
HETATM 6197 C C1  . NAG D 2 .   ? 122.338 150.555 127.573 1.00 40.64  ? 602 NAG A C1  1 
HETATM 6198 C C2  . NAG D 2 .   ? 123.115 151.377 126.517 1.00 44.73  ? 602 NAG A C2  1 
HETATM 6199 C C3  . NAG D 2 .   ? 123.363 150.535 125.252 1.00 50.83  ? 602 NAG A C3  1 
HETATM 6200 C C4  . NAG D 2 .   ? 123.918 149.122 125.494 1.00 50.79  ? 602 NAG A C4  1 
HETATM 6201 C C5  . NAG D 2 .   ? 123.015 148.405 126.510 1.00 47.02  ? 602 NAG A C5  1 
HETATM 6202 C C6  . NAG D 2 .   ? 123.547 147.055 126.931 1.00 50.26  ? 602 NAG A C6  1 
HETATM 6203 C C7  . NAG D 2 .   ? 122.885 153.852 126.037 1.00 39.74  ? 602 NAG A C7  1 
HETATM 6204 C C8  . NAG D 2 .   ? 124.350 154.110 126.311 1.00 36.17  ? 602 NAG A C8  1 
HETATM 6205 N N2  . NAG D 2 .   ? 122.416 152.586 126.157 1.00 39.59  ? 602 NAG A N2  1 
HETATM 6206 O O3  . NAG D 2 .   ? 124.214 151.281 124.423 1.00 43.95  ? 602 NAG A O3  1 
HETATM 6207 O O4  . NAG D 2 .   ? 123.946 148.454 124.255 1.00 51.07  ? 602 NAG A O4  1 
HETATM 6208 O O5  . NAG D 2 .   ? 122.870 149.234 127.664 1.00 44.06  ? 602 NAG A O5  1 
HETATM 6209 O O6  . NAG D 2 .   ? 122.716 146.500 127.921 1.00 51.40  ? 602 NAG A O6  1 
HETATM 6210 O O7  . NAG D 2 .   ? 122.159 154.779 125.716 1.00 40.13  ? 602 NAG A O7  1 
HETATM 6211 C C1  . NAG E 2 .   ? 111.359 164.148 162.355 1.00 104.79 ? 603 NAG A C1  1 
HETATM 6212 C C2  . NAG E 2 .   ? 111.009 163.408 163.680 1.00 110.83 ? 603 NAG A C2  1 
HETATM 6213 C C3  . NAG E 2 .   ? 109.527 162.958 163.581 1.00 106.64 ? 603 NAG A C3  1 
HETATM 6214 C C4  . NAG E 2 .   ? 108.541 164.103 163.280 1.00 105.64 ? 603 NAG A C4  1 
HETATM 6215 C C5  . NAG E 2 .   ? 109.057 164.960 162.084 1.00 103.94 ? 603 NAG A C5  1 
HETATM 6216 C C6  . NAG E 2 .   ? 108.280 166.238 161.868 1.00 100.39 ? 603 NAG A C6  1 
HETATM 6217 C C7  . NAG E 2 .   ? 112.864 162.343 164.943 1.00 102.96 ? 603 NAG A C7  1 
HETATM 6218 C C8  . NAG E 2 .   ? 113.694 161.093 165.074 1.00 100.54 ? 603 NAG A C8  1 
HETATM 6219 N N2  . NAG E 2 .   ? 111.911 162.319 163.986 1.00 110.18 ? 603 NAG A N2  1 
HETATM 6220 O O3  . NAG E 2 .   ? 109.197 162.263 164.754 1.00 100.74 ? 603 NAG A O3  1 
HETATM 6221 O O4  . NAG E 2 .   ? 107.291 163.495 163.037 1.00 101.76 ? 603 NAG A O4  1 
HETATM 6222 O O5  . NAG E 2 .   ? 110.467 165.261 162.230 1.00 105.72 ? 603 NAG A O5  1 
HETATM 6223 O O6  . NAG E 2 .   ? 108.011 166.781 163.134 1.00 106.28 ? 603 NAG A O6  1 
HETATM 6224 O O7  . NAG E 2 .   ? 113.073 163.295 165.681 1.00 97.79  ? 603 NAG A O7  1 
HETATM 6225 C C1  . NAG F 2 .   ? 149.004 127.997 132.703 1.00 107.14 ? 601 NAG B C1  1 
HETATM 6226 C C2  . NAG F 2 .   ? 149.998 128.133 133.886 1.00 106.43 ? 601 NAG B C2  1 
HETATM 6227 C C3  . NAG F 2 .   ? 149.803 129.499 134.587 1.00 105.24 ? 601 NAG B C3  1 
HETATM 6228 C C4  . NAG F 2 .   ? 149.748 130.718 133.648 1.00 106.29 ? 601 NAG B C4  1 
HETATM 6229 C C5  . NAG F 2 .   ? 148.742 130.444 132.509 1.00 105.70 ? 601 NAG B C5  1 
HETATM 6230 C C6  . NAG F 2 .   ? 148.715 131.521 131.448 1.00 104.86 ? 601 NAG B C6  1 
HETATM 6231 C C7  . NAG F 2 .   ? 148.994 126.526 135.600 1.00 104.99 ? 601 NAG B C7  1 
HETATM 6232 C C8  . NAG F 2 .   ? 149.414 125.323 136.406 1.00 99.43  ? 601 NAG B C8  1 
HETATM 6233 N N2  . NAG F 2 .   ? 149.978 127.011 134.805 1.00 106.86 ? 601 NAG B N2  1 
HETATM 6234 O O3  . NAG F 2 .   ? 150.829 129.639 135.534 1.00 103.80 ? 601 NAG B O3  1 
HETATM 6235 O O4  . NAG F 2 .   ? 149.385 131.835 134.425 1.00 107.19 ? 601 NAG B O4  1 
HETATM 6236 O O5  . NAG F 2 .   ? 149.054 129.181 131.905 1.00 104.89 ? 601 NAG B O5  1 
HETATM 6237 O O6  . NAG F 2 .   ? 148.265 132.730 132.012 1.00 103.09 ? 601 NAG B O6  1 
HETATM 6238 O O7  . NAG F 2 .   ? 147.857 126.967 135.706 1.00 104.14 ? 601 NAG B O7  1 
HETATM 6239 C C1  . NAG G 2 .   ? 126.662 98.450  127.569 1.00 39.47  ? 602 NAG B C1  1 
HETATM 6240 C C2  . NAG G 2 .   ? 125.884 97.629  126.513 1.00 41.01  ? 602 NAG B C2  1 
HETATM 6241 C C3  . NAG G 2 .   ? 125.635 98.471  125.249 1.00 44.57  ? 602 NAG B C3  1 
HETATM 6242 C C4  . NAG G 2 .   ? 125.081 99.884  125.491 1.00 44.89  ? 602 NAG B C4  1 
HETATM 6243 C C5  . NAG G 2 .   ? 125.985 100.601 126.507 1.00 42.84  ? 602 NAG B C5  1 
HETATM 6244 C C6  . NAG G 2 .   ? 125.452 101.949 126.931 1.00 44.42  ? 602 NAG B C6  1 
HETATM 6245 C C7  . NAG G 2 .   ? 126.114 95.153  126.037 1.00 38.69  ? 602 NAG B C7  1 
HETATM 6246 C C8  . NAG G 2 .   ? 124.650 94.895  126.314 1.00 36.45  ? 602 NAG B C8  1 
HETATM 6247 N N2  . NAG G 2 .   ? 126.582 96.419  126.154 1.00 38.22  ? 602 NAG B N2  1 
HETATM 6248 O O3  . NAG G 2 .   ? 124.782 97.725  124.421 1.00 41.47  ? 602 NAG B O3  1 
HETATM 6249 O O4  . NAG G 2 .   ? 125.051 100.554 124.254 1.00 46.04  ? 602 NAG B O4  1 
HETATM 6250 O O5  . NAG G 2 .   ? 126.131 99.771  127.661 1.00 41.09  ? 602 NAG B O5  1 
HETATM 6251 O O6  . NAG G 2 .   ? 126.283 102.504 127.922 1.00 46.86  ? 602 NAG B O6  1 
HETATM 6252 O O7  . NAG G 2 .   ? 126.839 94.225  125.716 1.00 39.91  ? 602 NAG B O7  1 
HETATM 6253 C C1  . NAG H 2 .   ? 137.642 84.864  162.349 1.00 95.73  ? 603 NAG B C1  1 
HETATM 6254 C C2  . NAG H 2 .   ? 137.992 85.601  163.677 1.00 99.24  ? 603 NAG B C2  1 
HETATM 6255 C C3  . NAG H 2 .   ? 139.474 86.052  163.579 1.00 97.08  ? 603 NAG B C3  1 
HETATM 6256 C C4  . NAG H 2 .   ? 140.459 84.907  163.278 1.00 97.41  ? 603 NAG B C4  1 
HETATM 6257 C C5  . NAG H 2 .   ? 139.945 84.051  162.080 1.00 95.97  ? 603 NAG B C5  1 
HETATM 6258 C C6  . NAG H 2 .   ? 140.721 82.772  161.865 1.00 93.18  ? 603 NAG B C6  1 
HETATM 6259 C C7  . NAG H 2 .   ? 136.137 86.665  164.942 1.00 94.23  ? 603 NAG B C7  1 
HETATM 6260 C C8  . NAG H 2 .   ? 135.307 87.915  165.075 1.00 93.69  ? 603 NAG B C8  1 
HETATM 6261 N N2  . NAG H 2 .   ? 137.090 86.689  163.984 1.00 98.58  ? 603 NAG B N2  1 
HETATM 6262 O O3  . NAG H 2 .   ? 139.803 86.745  164.753 1.00 91.24  ? 603 NAG B O3  1 
HETATM 6263 O O4  . NAG H 2 .   ? 141.710 85.514  163.037 1.00 93.40  ? 603 NAG B O4  1 
HETATM 6264 O O5  . NAG H 2 .   ? 138.534 83.750  162.224 1.00 95.98  ? 603 NAG B O5  1 
HETATM 6265 O O6  . NAG H 2 .   ? 140.985 82.227  163.130 1.00 95.60  ? 603 NAG B O6  1 
HETATM 6266 O O7  . NAG H 2 .   ? 135.928 85.713  165.679 1.00 90.39  ? 603 NAG B O7  1 
# 
