data_9BFI
# 
_entry.id   9BFI 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.400 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BFI         pdb_00009bfi 10.2210/pdb9bfi/pdb 
WWPDB D_1000283298 ?            ?                   
EMDB  EMD-44497    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2024-11-06 
2 'Structure model' 1 1 2025-01-15 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Data collection'     
2 2 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 2 'Structure model' em_admin        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_CSD'          
4  2 'Structure model' '_citation.journal_id_ISSN'         
5  2 'Structure model' '_citation.journal_volume'          
6  2 'Structure model' '_citation.page_first'              
7  2 'Structure model' '_citation.page_last'               
8  2 'Structure model' '_citation.pdbx_database_id_DOI'    
9  2 'Structure model' '_citation.pdbx_database_id_PubMed' 
10 2 'Structure model' '_citation.title'                   
11 2 'Structure model' '_citation.year'                    
12 2 'Structure model' '_em_admin.last_update'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BFI 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-17 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cryo-EM structure of human CHT1 in the apo inward-open state' 
_pdbx_database_related.db_id          EMD-44497 
_pdbx_database_related.content_type   'associated EM volume' 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
2 jxue1990@outlook.com             Jing    Xue   ? 'principal investigator/group leader' 0000-0002-7331-1382 
3 Youxing.Jiang@UTSouthwestern.edu Youxing Jiang ? 'principal investigator/group leader' 0000-0002-1874-0504 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Xue, J.'   1 0000-0002-7331-1382 
'Jiang, Y.' 2 0000-0002-1874-0504 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Cell Discov' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2056-5968 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            10 
_citation.language                  ? 
_citation.page_first                116 
_citation.page_last                 116 
_citation.title                     'Structural mechanisms of human sodium-coupled high-affinity choline transporter CHT1.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41421-024-00731-7 
_citation.pdbx_database_id_PubMed   39587078 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Xue, J.'   1 0000-0002-7331-1382 
primary 'Chen, H.'  2 ?                   
primary 'Wang, Y.'  3 0000-0001-9156-0377 
primary 'Jiang, Y.' 4 0000-0002-1874-0504 
# 
_entity.id                         1 
_entity.type                       polymer 
_entity.src_method                 man 
_entity.pdbx_description           'High affinity choline transporter 1' 
_entity.formula_weight             66526.625 
_entity.pdbx_number_of_molecules   1 
_entity.pdbx_ec                    ? 
_entity.pdbx_mutation              ? 
_entity.pdbx_fragment              ? 
_entity.details                    ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'hCHT1,Hemicholinium-3-sensitive choline transporter,CHT,Solute carrier family 5 member 7' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MAFHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYVPGY
GLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVD
MHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSW
LDSFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDPKTTEEADMIL
PIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTK
TVYGLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIFYPGYYPDDNGIYNQKFPFK
TLAMVTSFLTNICISYLAKYLFESGTLPPKLDVFDAVVARHSEENMDKTILVKNENIKLDELALVKPRQSMTLSSTFTNK
EAFLDVDSSPEGSGTEDNLQAAAGGSWSHPQFEKGGGSGGGSGGSAWSHPQFEK
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MAFHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYVPGY
GLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVD
MHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSW
LDSFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDPKTTEEADMIL
PIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTK
TVYGLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIFYPGYYPDDNGIYNQKFPFK
TLAMVTSFLTNICISYLAKYLFESGTLPPKLDVFDAVVARHSEENMDKTILVKNENIKLDELALVKPRQSMTLSSTFTNK
EAFLDVDSSPEGSGTEDNLQAAAGGSWSHPQFEKGGGSGGGSGGSAWSHPQFEK
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   PHE n 
1 4   HIS n 
1 5   VAL n 
1 6   GLU n 
1 7   GLY n 
1 8   LEU n 
1 9   ILE n 
1 10  ALA n 
1 11  ILE n 
1 12  ILE n 
1 13  VAL n 
1 14  PHE n 
1 15  TYR n 
1 16  LEU n 
1 17  LEU n 
1 18  ILE n 
1 19  LEU n 
1 20  LEU n 
1 21  VAL n 
1 22  GLY n 
1 23  ILE n 
1 24  TRP n 
1 25  ALA n 
1 26  ALA n 
1 27  TRP n 
1 28  ARG n 
1 29  THR n 
1 30  LYS n 
1 31  ASN n 
1 32  SER n 
1 33  GLY n 
1 34  SER n 
1 35  ALA n 
1 36  GLU n 
1 37  GLU n 
1 38  ARG n 
1 39  SER n 
1 40  GLU n 
1 41  ALA n 
1 42  ILE n 
1 43  ILE n 
1 44  VAL n 
1 45  GLY n 
1 46  GLY n 
1 47  ARG n 
1 48  ASP n 
1 49  ILE n 
1 50  GLY n 
1 51  LEU n 
1 52  LEU n 
1 53  VAL n 
1 54  GLY n 
1 55  GLY n 
1 56  PHE n 
1 57  THR n 
1 58  MET n 
1 59  THR n 
1 60  ALA n 
1 61  THR n 
1 62  TRP n 
1 63  VAL n 
1 64  GLY n 
1 65  GLY n 
1 66  GLY n 
1 67  TYR n 
1 68  ILE n 
1 69  ASN n 
1 70  GLY n 
1 71  THR n 
1 72  ALA n 
1 73  GLU n 
1 74  ALA n 
1 75  VAL n 
1 76  TYR n 
1 77  VAL n 
1 78  PRO n 
1 79  GLY n 
1 80  TYR n 
1 81  GLY n 
1 82  LEU n 
1 83  ALA n 
1 84  TRP n 
1 85  ALA n 
1 86  GLN n 
1 87  ALA n 
1 88  PRO n 
1 89  ILE n 
1 90  GLY n 
1 91  TYR n 
1 92  SER n 
1 93  LEU n 
1 94  SER n 
1 95  LEU n 
1 96  ILE n 
1 97  LEU n 
1 98  GLY n 
1 99  GLY n 
1 100 LEU n 
1 101 PHE n 
1 102 PHE n 
1 103 ALA n 
1 104 LYS n 
1 105 PRO n 
1 106 MET n 
1 107 ARG n 
1 108 SER n 
1 109 LYS n 
1 110 GLY n 
1 111 TYR n 
1 112 VAL n 
1 113 THR n 
1 114 MET n 
1 115 LEU n 
1 116 ASP n 
1 117 PRO n 
1 118 PHE n 
1 119 GLN n 
1 120 GLN n 
1 121 ILE n 
1 122 TYR n 
1 123 GLY n 
1 124 LYS n 
1 125 ARG n 
1 126 MET n 
1 127 GLY n 
1 128 GLY n 
1 129 LEU n 
1 130 LEU n 
1 131 PHE n 
1 132 ILE n 
1 133 PRO n 
1 134 ALA n 
1 135 LEU n 
1 136 MET n 
1 137 GLY n 
1 138 GLU n 
1 139 MET n 
1 140 PHE n 
1 141 TRP n 
1 142 ALA n 
1 143 ALA n 
1 144 ALA n 
1 145 ILE n 
1 146 PHE n 
1 147 SER n 
1 148 ALA n 
1 149 LEU n 
1 150 GLY n 
1 151 ALA n 
1 152 THR n 
1 153 ILE n 
1 154 SER n 
1 155 VAL n 
1 156 ILE n 
1 157 ILE n 
1 158 ASP n 
1 159 VAL n 
1 160 ASP n 
1 161 MET n 
1 162 HIS n 
1 163 ILE n 
1 164 SER n 
1 165 VAL n 
1 166 ILE n 
1 167 ILE n 
1 168 SER n 
1 169 ALA n 
1 170 LEU n 
1 171 ILE n 
1 172 ALA n 
1 173 THR n 
1 174 LEU n 
1 175 TYR n 
1 176 THR n 
1 177 LEU n 
1 178 VAL n 
1 179 GLY n 
1 180 GLY n 
1 181 LEU n 
1 182 TYR n 
1 183 SER n 
1 184 VAL n 
1 185 ALA n 
1 186 TYR n 
1 187 THR n 
1 188 ASP n 
1 189 VAL n 
1 190 VAL n 
1 191 GLN n 
1 192 LEU n 
1 193 PHE n 
1 194 CYS n 
1 195 ILE n 
1 196 PHE n 
1 197 VAL n 
1 198 GLY n 
1 199 LEU n 
1 200 TRP n 
1 201 ILE n 
1 202 SER n 
1 203 VAL n 
1 204 PRO n 
1 205 PHE n 
1 206 ALA n 
1 207 LEU n 
1 208 SER n 
1 209 HIS n 
1 210 PRO n 
1 211 ALA n 
1 212 VAL n 
1 213 ALA n 
1 214 ASP n 
1 215 ILE n 
1 216 GLY n 
1 217 PHE n 
1 218 THR n 
1 219 ALA n 
1 220 VAL n 
1 221 HIS n 
1 222 ALA n 
1 223 LYS n 
1 224 TYR n 
1 225 GLN n 
1 226 LYS n 
1 227 PRO n 
1 228 TRP n 
1 229 LEU n 
1 230 GLY n 
1 231 THR n 
1 232 VAL n 
1 233 ASP n 
1 234 SER n 
1 235 SER n 
1 236 GLU n 
1 237 VAL n 
1 238 TYR n 
1 239 SER n 
1 240 TRP n 
1 241 LEU n 
1 242 ASP n 
1 243 SER n 
1 244 PHE n 
1 245 LEU n 
1 246 LEU n 
1 247 LEU n 
1 248 MET n 
1 249 LEU n 
1 250 GLY n 
1 251 GLY n 
1 252 ILE n 
1 253 PRO n 
1 254 TRP n 
1 255 GLN n 
1 256 ALA n 
1 257 TYR n 
1 258 PHE n 
1 259 GLN n 
1 260 ARG n 
1 261 VAL n 
1 262 LEU n 
1 263 SER n 
1 264 SER n 
1 265 SER n 
1 266 SER n 
1 267 ALA n 
1 268 THR n 
1 269 TYR n 
1 270 ALA n 
1 271 GLN n 
1 272 VAL n 
1 273 LEU n 
1 274 SER n 
1 275 PHE n 
1 276 LEU n 
1 277 ALA n 
1 278 ALA n 
1 279 PHE n 
1 280 GLY n 
1 281 CYS n 
1 282 LEU n 
1 283 VAL n 
1 284 MET n 
1 285 ALA n 
1 286 ILE n 
1 287 PRO n 
1 288 ALA n 
1 289 ILE n 
1 290 LEU n 
1 291 ILE n 
1 292 GLY n 
1 293 ALA n 
1 294 ILE n 
1 295 GLY n 
1 296 ALA n 
1 297 SER n 
1 298 THR n 
1 299 ASP n 
1 300 TRP n 
1 301 ASN n 
1 302 GLN n 
1 303 THR n 
1 304 ALA n 
1 305 TYR n 
1 306 GLY n 
1 307 LEU n 
1 308 PRO n 
1 309 ASP n 
1 310 PRO n 
1 311 LYS n 
1 312 THR n 
1 313 THR n 
1 314 GLU n 
1 315 GLU n 
1 316 ALA n 
1 317 ASP n 
1 318 MET n 
1 319 ILE n 
1 320 LEU n 
1 321 PRO n 
1 322 ILE n 
1 323 VAL n 
1 324 LEU n 
1 325 GLN n 
1 326 TYR n 
1 327 LEU n 
1 328 CYS n 
1 329 PRO n 
1 330 VAL n 
1 331 TYR n 
1 332 ILE n 
1 333 SER n 
1 334 PHE n 
1 335 PHE n 
1 336 GLY n 
1 337 LEU n 
1 338 GLY n 
1 339 ALA n 
1 340 VAL n 
1 341 SER n 
1 342 ALA n 
1 343 ALA n 
1 344 VAL n 
1 345 MET n 
1 346 SER n 
1 347 SER n 
1 348 ALA n 
1 349 ASP n 
1 350 SER n 
1 351 SER n 
1 352 ILE n 
1 353 LEU n 
1 354 SER n 
1 355 ALA n 
1 356 SER n 
1 357 SER n 
1 358 MET n 
1 359 PHE n 
1 360 ALA n 
1 361 ARG n 
1 362 ASN n 
1 363 ILE n 
1 364 TYR n 
1 365 GLN n 
1 366 LEU n 
1 367 SER n 
1 368 PHE n 
1 369 ARG n 
1 370 GLN n 
1 371 ASN n 
1 372 ALA n 
1 373 SER n 
1 374 ASP n 
1 375 LYS n 
1 376 GLU n 
1 377 ILE n 
1 378 VAL n 
1 379 TRP n 
1 380 VAL n 
1 381 MET n 
1 382 ARG n 
1 383 ILE n 
1 384 THR n 
1 385 VAL n 
1 386 PHE n 
1 387 VAL n 
1 388 PHE n 
1 389 GLY n 
1 390 ALA n 
1 391 SER n 
1 392 ALA n 
1 393 THR n 
1 394 ALA n 
1 395 MET n 
1 396 ALA n 
1 397 LEU n 
1 398 LEU n 
1 399 THR n 
1 400 LYS n 
1 401 THR n 
1 402 VAL n 
1 403 TYR n 
1 404 GLY n 
1 405 LEU n 
1 406 TRP n 
1 407 TYR n 
1 408 LEU n 
1 409 SER n 
1 410 SER n 
1 411 ASP n 
1 412 LEU n 
1 413 VAL n 
1 414 TYR n 
1 415 ILE n 
1 416 VAL n 
1 417 ILE n 
1 418 PHE n 
1 419 PRO n 
1 420 GLN n 
1 421 LEU n 
1 422 LEU n 
1 423 CYS n 
1 424 VAL n 
1 425 LEU n 
1 426 PHE n 
1 427 VAL n 
1 428 LYS n 
1 429 GLY n 
1 430 THR n 
1 431 ASN n 
1 432 THR n 
1 433 TYR n 
1 434 GLY n 
1 435 ALA n 
1 436 VAL n 
1 437 ALA n 
1 438 GLY n 
1 439 TYR n 
1 440 VAL n 
1 441 SER n 
1 442 GLY n 
1 443 LEU n 
1 444 PHE n 
1 445 LEU n 
1 446 ARG n 
1 447 ILE n 
1 448 THR n 
1 449 GLY n 
1 450 GLY n 
1 451 GLU n 
1 452 PRO n 
1 453 TYR n 
1 454 LEU n 
1 455 TYR n 
1 456 LEU n 
1 457 GLN n 
1 458 PRO n 
1 459 LEU n 
1 460 ILE n 
1 461 PHE n 
1 462 TYR n 
1 463 PRO n 
1 464 GLY n 
1 465 TYR n 
1 466 TYR n 
1 467 PRO n 
1 468 ASP n 
1 469 ASP n 
1 470 ASN n 
1 471 GLY n 
1 472 ILE n 
1 473 TYR n 
1 474 ASN n 
1 475 GLN n 
1 476 LYS n 
1 477 PHE n 
1 478 PRO n 
1 479 PHE n 
1 480 LYS n 
1 481 THR n 
1 482 LEU n 
1 483 ALA n 
1 484 MET n 
1 485 VAL n 
1 486 THR n 
1 487 SER n 
1 488 PHE n 
1 489 LEU n 
1 490 THR n 
1 491 ASN n 
1 492 ILE n 
1 493 CYS n 
1 494 ILE n 
1 495 SER n 
1 496 TYR n 
1 497 LEU n 
1 498 ALA n 
1 499 LYS n 
1 500 TYR n 
1 501 LEU n 
1 502 PHE n 
1 503 GLU n 
1 504 SER n 
1 505 GLY n 
1 506 THR n 
1 507 LEU n 
1 508 PRO n 
1 509 PRO n 
1 510 LYS n 
1 511 LEU n 
1 512 ASP n 
1 513 VAL n 
1 514 PHE n 
1 515 ASP n 
1 516 ALA n 
1 517 VAL n 
1 518 VAL n 
1 519 ALA n 
1 520 ARG n 
1 521 HIS n 
1 522 SER n 
1 523 GLU n 
1 524 GLU n 
1 525 ASN n 
1 526 MET n 
1 527 ASP n 
1 528 LYS n 
1 529 THR n 
1 530 ILE n 
1 531 LEU n 
1 532 VAL n 
1 533 LYS n 
1 534 ASN n 
1 535 GLU n 
1 536 ASN n 
1 537 ILE n 
1 538 LYS n 
1 539 LEU n 
1 540 ASP n 
1 541 GLU n 
1 542 LEU n 
1 543 ALA n 
1 544 LEU n 
1 545 VAL n 
1 546 LYS n 
1 547 PRO n 
1 548 ARG n 
1 549 GLN n 
1 550 SER n 
1 551 MET n 
1 552 THR n 
1 553 LEU n 
1 554 SER n 
1 555 SER n 
1 556 THR n 
1 557 PHE n 
1 558 THR n 
1 559 ASN n 
1 560 LYS n 
1 561 GLU n 
1 562 ALA n 
1 563 PHE n 
1 564 LEU n 
1 565 ASP n 
1 566 VAL n 
1 567 ASP n 
1 568 SER n 
1 569 SER n 
1 570 PRO n 
1 571 GLU n 
1 572 GLY n 
1 573 SER n 
1 574 GLY n 
1 575 THR n 
1 576 GLU n 
1 577 ASP n 
1 578 ASN n 
1 579 LEU n 
1 580 GLN n 
1 581 ALA n 
1 582 ALA n 
1 583 ALA n 
1 584 GLY n 
1 585 GLY n 
1 586 SER n 
1 587 TRP n 
1 588 SER n 
1 589 HIS n 
1 590 PRO n 
1 591 GLN n 
1 592 PHE n 
1 593 GLU n 
1 594 LYS n 
1 595 GLY n 
1 596 GLY n 
1 597 GLY n 
1 598 SER n 
1 599 GLY n 
1 600 GLY n 
1 601 GLY n 
1 602 SER n 
1 603 GLY n 
1 604 GLY n 
1 605 SER n 
1 606 ALA n 
1 607 TRP n 
1 608 SER n 
1 609 HIS n 
1 610 PRO n 
1 611 GLN n 
1 612 PHE n 
1 613 GLU n 
1 614 LYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   614 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'SLC5A7, CHT1' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ALA 2   2   2   ALA ALA A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   HIS 4   4   4   HIS HIS A . n 
A 1 5   VAL 5   5   5   VAL VAL A . n 
A 1 6   GLU 6   6   6   GLU GLU A . n 
A 1 7   GLY 7   7   7   GLY GLY A . n 
A 1 8   LEU 8   8   8   LEU LEU A . n 
A 1 9   ILE 9   9   9   ILE ILE A . n 
A 1 10  ALA 10  10  10  ALA ALA A . n 
A 1 11  ILE 11  11  11  ILE ILE A . n 
A 1 12  ILE 12  12  12  ILE ILE A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  PHE 14  14  14  PHE PHE A . n 
A 1 15  TYR 15  15  15  TYR TYR A . n 
A 1 16  LEU 16  16  16  LEU LEU A . n 
A 1 17  LEU 17  17  17  LEU LEU A . n 
A 1 18  ILE 18  18  18  ILE ILE A . n 
A 1 19  LEU 19  19  19  LEU LEU A . n 
A 1 20  LEU 20  20  20  LEU LEU A . n 
A 1 21  VAL 21  21  21  VAL VAL A . n 
A 1 22  GLY 22  22  22  GLY GLY A . n 
A 1 23  ILE 23  23  23  ILE ILE A . n 
A 1 24  TRP 24  24  24  TRP TRP A . n 
A 1 25  ALA 25  25  25  ALA ALA A . n 
A 1 26  ALA 26  26  26  ALA ALA A . n 
A 1 27  TRP 27  27  27  TRP TRP A . n 
A 1 28  ARG 28  28  28  ARG ARG A . n 
A 1 29  THR 29  29  29  THR THR A . n 
A 1 30  LYS 30  30  ?   ?   ?   A . n 
A 1 31  ASN 31  31  ?   ?   ?   A . n 
A 1 32  SER 32  32  ?   ?   ?   A . n 
A 1 33  GLY 33  33  ?   ?   ?   A . n 
A 1 34  SER 34  34  ?   ?   ?   A . n 
A 1 35  ALA 35  35  ?   ?   ?   A . n 
A 1 36  GLU 36  36  ?   ?   ?   A . n 
A 1 37  GLU 37  37  ?   ?   ?   A . n 
A 1 38  ARG 38  38  ?   ?   ?   A . n 
A 1 39  SER 39  39  ?   ?   ?   A . n 
A 1 40  GLU 40  40  ?   ?   ?   A . n 
A 1 41  ALA 41  41  ?   ?   ?   A . n 
A 1 42  ILE 42  42  ?   ?   ?   A . n 
A 1 43  ILE 43  43  ?   ?   ?   A . n 
A 1 44  VAL 44  44  ?   ?   ?   A . n 
A 1 45  GLY 45  45  ?   ?   ?   A . n 
A 1 46  GLY 46  46  ?   ?   ?   A . n 
A 1 47  ARG 47  47  47  ARG ARG A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  ILE 49  49  49  ILE ILE A . n 
A 1 50  GLY 50  50  50  GLY GLY A . n 
A 1 51  LEU 51  51  51  LEU LEU A . n 
A 1 52  LEU 52  52  52  LEU LEU A . n 
A 1 53  VAL 53  53  53  VAL VAL A . n 
A 1 54  GLY 54  54  54  GLY GLY A . n 
A 1 55  GLY 55  55  55  GLY GLY A . n 
A 1 56  PHE 56  56  56  PHE PHE A . n 
A 1 57  THR 57  57  57  THR THR A . n 
A 1 58  MET 58  58  58  MET MET A . n 
A 1 59  THR 59  59  59  THR THR A . n 
A 1 60  ALA 60  60  60  ALA ALA A . n 
A 1 61  THR 61  61  61  THR THR A . n 
A 1 62  TRP 62  62  62  TRP TRP A . n 
A 1 63  VAL 63  63  63  VAL VAL A . n 
A 1 64  GLY 64  64  64  GLY GLY A . n 
A 1 65  GLY 65  65  65  GLY GLY A . n 
A 1 66  GLY 66  66  66  GLY GLY A . n 
A 1 67  TYR 67  67  67  TYR TYR A . n 
A 1 68  ILE 68  68  68  ILE ILE A . n 
A 1 69  ASN 69  69  69  ASN ASN A . n 
A 1 70  GLY 70  70  70  GLY GLY A . n 
A 1 71  THR 71  71  71  THR THR A . n 
A 1 72  ALA 72  72  72  ALA ALA A . n 
A 1 73  GLU 73  73  73  GLU GLU A . n 
A 1 74  ALA 74  74  74  ALA ALA A . n 
A 1 75  VAL 75  75  75  VAL VAL A . n 
A 1 76  TYR 76  76  76  TYR TYR A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  PRO 78  78  78  PRO PRO A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  TYR 80  80  80  TYR TYR A . n 
A 1 81  GLY 81  81  81  GLY GLY A . n 
A 1 82  LEU 82  82  82  LEU LEU A . n 
A 1 83  ALA 83  83  83  ALA ALA A . n 
A 1 84  TRP 84  84  84  TRP TRP A . n 
A 1 85  ALA 85  85  85  ALA ALA A . n 
A 1 86  GLN 86  86  86  GLN GLN A . n 
A 1 87  ALA 87  87  87  ALA ALA A . n 
A 1 88  PRO 88  88  88  PRO PRO A . n 
A 1 89  ILE 89  89  89  ILE ILE A . n 
A 1 90  GLY 90  90  90  GLY GLY A . n 
A 1 91  TYR 91  91  91  TYR TYR A . n 
A 1 92  SER 92  92  92  SER SER A . n 
A 1 93  LEU 93  93  93  LEU LEU A . n 
A 1 94  SER 94  94  94  SER SER A . n 
A 1 95  LEU 95  95  95  LEU LEU A . n 
A 1 96  ILE 96  96  96  ILE ILE A . n 
A 1 97  LEU 97  97  97  LEU LEU A . n 
A 1 98  GLY 98  98  98  GLY GLY A . n 
A 1 99  GLY 99  99  99  GLY GLY A . n 
A 1 100 LEU 100 100 100 LEU LEU A . n 
A 1 101 PHE 101 101 101 PHE PHE A . n 
A 1 102 PHE 102 102 102 PHE PHE A . n 
A 1 103 ALA 103 103 103 ALA ALA A . n 
A 1 104 LYS 104 104 104 LYS LYS A . n 
A 1 105 PRO 105 105 105 PRO PRO A . n 
A 1 106 MET 106 106 106 MET MET A . n 
A 1 107 ARG 107 107 107 ARG ARG A . n 
A 1 108 SER 108 108 108 SER SER A . n 
A 1 109 LYS 109 109 109 LYS LYS A . n 
A 1 110 GLY 110 110 110 GLY GLY A . n 
A 1 111 TYR 111 111 111 TYR TYR A . n 
A 1 112 VAL 112 112 112 VAL VAL A . n 
A 1 113 THR 113 113 113 THR THR A . n 
A 1 114 MET 114 114 114 MET MET A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ASP 116 116 116 ASP ASP A . n 
A 1 117 PRO 117 117 117 PRO PRO A . n 
A 1 118 PHE 118 118 118 PHE PHE A . n 
A 1 119 GLN 119 119 119 GLN GLN A . n 
A 1 120 GLN 120 120 120 GLN GLN A . n 
A 1 121 ILE 121 121 121 ILE ILE A . n 
A 1 122 TYR 122 122 122 TYR TYR A . n 
A 1 123 GLY 123 123 123 GLY GLY A . n 
A 1 124 LYS 124 124 124 LYS LYS A . n 
A 1 125 ARG 125 125 125 ARG ARG A . n 
A 1 126 MET 126 126 126 MET MET A . n 
A 1 127 GLY 127 127 127 GLY GLY A . n 
A 1 128 GLY 128 128 128 GLY GLY A . n 
A 1 129 LEU 129 129 129 LEU LEU A . n 
A 1 130 LEU 130 130 130 LEU LEU A . n 
A 1 131 PHE 131 131 131 PHE PHE A . n 
A 1 132 ILE 132 132 132 ILE ILE A . n 
A 1 133 PRO 133 133 133 PRO PRO A . n 
A 1 134 ALA 134 134 134 ALA ALA A . n 
A 1 135 LEU 135 135 135 LEU LEU A . n 
A 1 136 MET 136 136 136 MET MET A . n 
A 1 137 GLY 137 137 137 GLY GLY A . n 
A 1 138 GLU 138 138 138 GLU GLU A . n 
A 1 139 MET 139 139 139 MET MET A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 TRP 141 141 141 TRP TRP A . n 
A 1 142 ALA 142 142 142 ALA ALA A . n 
A 1 143 ALA 143 143 143 ALA ALA A . n 
A 1 144 ALA 144 144 144 ALA ALA A . n 
A 1 145 ILE 145 145 145 ILE ILE A . n 
A 1 146 PHE 146 146 146 PHE PHE A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 ALA 148 148 148 ALA ALA A . n 
A 1 149 LEU 149 149 149 LEU LEU A . n 
A 1 150 GLY 150 150 150 GLY GLY A . n 
A 1 151 ALA 151 151 151 ALA ALA A . n 
A 1 152 THR 152 152 152 THR THR A . n 
A 1 153 ILE 153 153 153 ILE ILE A . n 
A 1 154 SER 154 154 154 SER SER A . n 
A 1 155 VAL 155 155 155 VAL VAL A . n 
A 1 156 ILE 156 156 156 ILE ILE A . n 
A 1 157 ILE 157 157 157 ILE ILE A . n 
A 1 158 ASP 158 158 158 ASP ASP A . n 
A 1 159 VAL 159 159 159 VAL VAL A . n 
A 1 160 ASP 160 160 160 ASP ASP A . n 
A 1 161 MET 161 161 161 MET MET A . n 
A 1 162 HIS 162 162 162 HIS HIS A . n 
A 1 163 ILE 163 163 163 ILE ILE A . n 
A 1 164 SER 164 164 164 SER SER A . n 
A 1 165 VAL 165 165 165 VAL VAL A . n 
A 1 166 ILE 166 166 166 ILE ILE A . n 
A 1 167 ILE 167 167 167 ILE ILE A . n 
A 1 168 SER 168 168 168 SER SER A . n 
A 1 169 ALA 169 169 169 ALA ALA A . n 
A 1 170 LEU 170 170 170 LEU LEU A . n 
A 1 171 ILE 171 171 171 ILE ILE A . n 
A 1 172 ALA 172 172 172 ALA ALA A . n 
A 1 173 THR 173 173 173 THR THR A . n 
A 1 174 LEU 174 174 174 LEU LEU A . n 
A 1 175 TYR 175 175 175 TYR TYR A . n 
A 1 176 THR 176 176 176 THR THR A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 VAL 178 178 178 VAL VAL A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 GLY 180 180 ?   ?   ?   A . n 
A 1 181 LEU 181 181 ?   ?   ?   A . n 
A 1 182 TYR 182 182 ?   ?   ?   A . n 
A 1 183 SER 183 183 183 SER SER A . n 
A 1 184 VAL 184 184 184 VAL VAL A . n 
A 1 185 ALA 185 185 185 ALA ALA A . n 
A 1 186 TYR 186 186 186 TYR TYR A . n 
A 1 187 THR 187 187 187 THR THR A . n 
A 1 188 ASP 188 188 188 ASP ASP A . n 
A 1 189 VAL 189 189 189 VAL VAL A . n 
A 1 190 VAL 190 190 190 VAL VAL A . n 
A 1 191 GLN 191 191 191 GLN GLN A . n 
A 1 192 LEU 192 192 192 LEU LEU A . n 
A 1 193 PHE 193 193 193 PHE PHE A . n 
A 1 194 CYS 194 194 194 CYS CYS A . n 
A 1 195 ILE 195 195 195 ILE ILE A . n 
A 1 196 PHE 196 196 196 PHE PHE A . n 
A 1 197 VAL 197 197 197 VAL VAL A . n 
A 1 198 GLY 198 198 198 GLY GLY A . n 
A 1 199 LEU 199 199 199 LEU LEU A . n 
A 1 200 TRP 200 200 200 TRP TRP A . n 
A 1 201 ILE 201 201 201 ILE ILE A . n 
A 1 202 SER 202 202 202 SER SER A . n 
A 1 203 VAL 203 203 203 VAL VAL A . n 
A 1 204 PRO 204 204 204 PRO PRO A . n 
A 1 205 PHE 205 205 205 PHE PHE A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 LEU 207 207 207 LEU LEU A . n 
A 1 208 SER 208 208 208 SER SER A . n 
A 1 209 HIS 209 209 209 HIS HIS A . n 
A 1 210 PRO 210 210 210 PRO PRO A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ALA 213 213 213 ALA ALA A . n 
A 1 214 ASP 214 214 214 ASP ASP A . n 
A 1 215 ILE 215 215 215 ILE ILE A . n 
A 1 216 GLY 216 216 216 GLY GLY A . n 
A 1 217 PHE 217 217 217 PHE PHE A . n 
A 1 218 THR 218 218 218 THR THR A . n 
A 1 219 ALA 219 219 219 ALA ALA A . n 
A 1 220 VAL 220 220 220 VAL VAL A . n 
A 1 221 HIS 221 221 221 HIS HIS A . n 
A 1 222 ALA 222 222 222 ALA ALA A . n 
A 1 223 LYS 223 223 223 LYS LYS A . n 
A 1 224 TYR 224 224 224 TYR TYR A . n 
A 1 225 GLN 225 225 225 GLN GLN A . n 
A 1 226 LYS 226 226 226 LYS LYS A . n 
A 1 227 PRO 227 227 227 PRO PRO A . n 
A 1 228 TRP 228 228 228 TRP TRP A . n 
A 1 229 LEU 229 229 229 LEU LEU A . n 
A 1 230 GLY 230 230 230 GLY GLY A . n 
A 1 231 THR 231 231 231 THR THR A . n 
A 1 232 VAL 232 232 232 VAL VAL A . n 
A 1 233 ASP 233 233 233 ASP ASP A . n 
A 1 234 SER 234 234 234 SER SER A . n 
A 1 235 SER 235 235 235 SER SER A . n 
A 1 236 GLU 236 236 236 GLU GLU A . n 
A 1 237 VAL 237 237 237 VAL VAL A . n 
A 1 238 TYR 238 238 238 TYR TYR A . n 
A 1 239 SER 239 239 239 SER SER A . n 
A 1 240 TRP 240 240 240 TRP TRP A . n 
A 1 241 LEU 241 241 241 LEU LEU A . n 
A 1 242 ASP 242 242 242 ASP ASP A . n 
A 1 243 SER 243 243 243 SER SER A . n 
A 1 244 PHE 244 244 244 PHE PHE A . n 
A 1 245 LEU 245 245 245 LEU LEU A . n 
A 1 246 LEU 246 246 246 LEU LEU A . n 
A 1 247 LEU 247 247 247 LEU LEU A . n 
A 1 248 MET 248 248 248 MET MET A . n 
A 1 249 LEU 249 249 249 LEU LEU A . n 
A 1 250 GLY 250 250 250 GLY GLY A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 ILE 252 252 252 ILE ILE A . n 
A 1 253 PRO 253 253 253 PRO PRO A . n 
A 1 254 TRP 254 254 254 TRP TRP A . n 
A 1 255 GLN 255 255 255 GLN GLN A . n 
A 1 256 ALA 256 256 256 ALA ALA A . n 
A 1 257 TYR 257 257 257 TYR TYR A . n 
A 1 258 PHE 258 258 258 PHE PHE A . n 
A 1 259 GLN 259 259 259 GLN GLN A . n 
A 1 260 ARG 260 260 260 ARG ARG A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 SER 263 263 263 SER SER A . n 
A 1 264 SER 264 264 264 SER SER A . n 
A 1 265 SER 265 265 265 SER SER A . n 
A 1 266 SER 266 266 266 SER SER A . n 
A 1 267 ALA 267 267 267 ALA ALA A . n 
A 1 268 THR 268 268 268 THR THR A . n 
A 1 269 TYR 269 269 269 TYR TYR A . n 
A 1 270 ALA 270 270 270 ALA ALA A . n 
A 1 271 GLN 271 271 271 GLN GLN A . n 
A 1 272 VAL 272 272 272 VAL VAL A . n 
A 1 273 LEU 273 273 273 LEU LEU A . n 
A 1 274 SER 274 274 274 SER SER A . n 
A 1 275 PHE 275 275 275 PHE PHE A . n 
A 1 276 LEU 276 276 276 LEU LEU A . n 
A 1 277 ALA 277 277 277 ALA ALA A . n 
A 1 278 ALA 278 278 278 ALA ALA A . n 
A 1 279 PHE 279 279 279 PHE PHE A . n 
A 1 280 GLY 280 280 280 GLY GLY A . n 
A 1 281 CYS 281 281 281 CYS CYS A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 VAL 283 283 283 VAL VAL A . n 
A 1 284 MET 284 284 284 MET MET A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 ILE 286 286 286 ILE ILE A . n 
A 1 287 PRO 287 287 287 PRO PRO A . n 
A 1 288 ALA 288 288 288 ALA ALA A . n 
A 1 289 ILE 289 289 289 ILE ILE A . n 
A 1 290 LEU 290 290 290 LEU LEU A . n 
A 1 291 ILE 291 291 291 ILE ILE A . n 
A 1 292 GLY 292 292 292 GLY GLY A . n 
A 1 293 ALA 293 293 293 ALA ALA A . n 
A 1 294 ILE 294 294 294 ILE ILE A . n 
A 1 295 GLY 295 295 295 GLY GLY A . n 
A 1 296 ALA 296 296 296 ALA ALA A . n 
A 1 297 SER 297 297 297 SER SER A . n 
A 1 298 THR 298 298 298 THR THR A . n 
A 1 299 ASP 299 299 299 ASP ASP A . n 
A 1 300 TRP 300 300 300 TRP TRP A . n 
A 1 301 ASN 301 301 301 ASN ASN A . n 
A 1 302 GLN 302 302 302 GLN GLN A . n 
A 1 303 THR 303 303 303 THR THR A . n 
A 1 304 ALA 304 304 304 ALA ALA A . n 
A 1 305 TYR 305 305 305 TYR TYR A . n 
A 1 306 GLY 306 306 306 GLY GLY A . n 
A 1 307 LEU 307 307 307 LEU LEU A . n 
A 1 308 PRO 308 308 308 PRO PRO A . n 
A 1 309 ASP 309 309 309 ASP ASP A . n 
A 1 310 PRO 310 310 310 PRO PRO A . n 
A 1 311 LYS 311 311 311 LYS LYS A . n 
A 1 312 THR 312 312 312 THR THR A . n 
A 1 313 THR 313 313 313 THR THR A . n 
A 1 314 GLU 314 314 314 GLU GLU A . n 
A 1 315 GLU 315 315 315 GLU GLU A . n 
A 1 316 ALA 316 316 316 ALA ALA A . n 
A 1 317 ASP 317 317 317 ASP ASP A . n 
A 1 318 MET 318 318 318 MET MET A . n 
A 1 319 ILE 319 319 319 ILE ILE A . n 
A 1 320 LEU 320 320 320 LEU LEU A . n 
A 1 321 PRO 321 321 321 PRO PRO A . n 
A 1 322 ILE 322 322 322 ILE ILE A . n 
A 1 323 VAL 323 323 323 VAL VAL A . n 
A 1 324 LEU 324 324 324 LEU LEU A . n 
A 1 325 GLN 325 325 325 GLN GLN A . n 
A 1 326 TYR 326 326 326 TYR TYR A . n 
A 1 327 LEU 327 327 327 LEU LEU A . n 
A 1 328 CYS 328 328 328 CYS CYS A . n 
A 1 329 PRO 329 329 329 PRO PRO A . n 
A 1 330 VAL 330 330 330 VAL VAL A . n 
A 1 331 TYR 331 331 331 TYR TYR A . n 
A 1 332 ILE 332 332 332 ILE ILE A . n 
A 1 333 SER 333 333 333 SER SER A . n 
A 1 334 PHE 334 334 334 PHE PHE A . n 
A 1 335 PHE 335 335 335 PHE PHE A . n 
A 1 336 GLY 336 336 336 GLY GLY A . n 
A 1 337 LEU 337 337 337 LEU LEU A . n 
A 1 338 GLY 338 338 338 GLY GLY A . n 
A 1 339 ALA 339 339 339 ALA ALA A . n 
A 1 340 VAL 340 340 340 VAL VAL A . n 
A 1 341 SER 341 341 341 SER SER A . n 
A 1 342 ALA 342 342 342 ALA ALA A . n 
A 1 343 ALA 343 343 343 ALA ALA A . n 
A 1 344 VAL 344 344 344 VAL VAL A . n 
A 1 345 MET 345 345 345 MET MET A . n 
A 1 346 SER 346 346 346 SER SER A . n 
A 1 347 SER 347 347 347 SER SER A . n 
A 1 348 ALA 348 348 348 ALA ALA A . n 
A 1 349 ASP 349 349 349 ASP ASP A . n 
A 1 350 SER 350 350 350 SER SER A . n 
A 1 351 SER 351 351 351 SER SER A . n 
A 1 352 ILE 352 352 352 ILE ILE A . n 
A 1 353 LEU 353 353 353 LEU LEU A . n 
A 1 354 SER 354 354 354 SER SER A . n 
A 1 355 ALA 355 355 355 ALA ALA A . n 
A 1 356 SER 356 356 356 SER SER A . n 
A 1 357 SER 357 357 357 SER SER A . n 
A 1 358 MET 358 358 358 MET MET A . n 
A 1 359 PHE 359 359 359 PHE PHE A . n 
A 1 360 ALA 360 360 360 ALA ALA A . n 
A 1 361 ARG 361 361 361 ARG ARG A . n 
A 1 362 ASN 362 362 362 ASN ASN A . n 
A 1 363 ILE 363 363 363 ILE ILE A . n 
A 1 364 TYR 364 364 364 TYR TYR A . n 
A 1 365 GLN 365 365 365 GLN GLN A . n 
A 1 366 LEU 366 366 366 LEU LEU A . n 
A 1 367 SER 367 367 367 SER SER A . n 
A 1 368 PHE 368 368 368 PHE PHE A . n 
A 1 369 ARG 369 369 ?   ?   ?   A . n 
A 1 370 GLN 370 370 ?   ?   ?   A . n 
A 1 371 ASN 371 371 ?   ?   ?   A . n 
A 1 372 ALA 372 372 ?   ?   ?   A . n 
A 1 373 SER 373 373 ?   ?   ?   A . n 
A 1 374 ASP 374 374 ?   ?   ?   A . n 
A 1 375 LYS 375 375 ?   ?   ?   A . n 
A 1 376 GLU 376 376 376 GLU GLU A . n 
A 1 377 ILE 377 377 377 ILE ILE A . n 
A 1 378 VAL 378 378 378 VAL VAL A . n 
A 1 379 TRP 379 379 379 TRP TRP A . n 
A 1 380 VAL 380 380 380 VAL VAL A . n 
A 1 381 MET 381 381 381 MET MET A . n 
A 1 382 ARG 382 382 382 ARG ARG A . n 
A 1 383 ILE 383 383 383 ILE ILE A . n 
A 1 384 THR 384 384 384 THR THR A . n 
A 1 385 VAL 385 385 385 VAL VAL A . n 
A 1 386 PHE 386 386 386 PHE PHE A . n 
A 1 387 VAL 387 387 387 VAL VAL A . n 
A 1 388 PHE 388 388 388 PHE PHE A . n 
A 1 389 GLY 389 389 389 GLY GLY A . n 
A 1 390 ALA 390 390 390 ALA ALA A . n 
A 1 391 SER 391 391 391 SER SER A . n 
A 1 392 ALA 392 392 392 ALA ALA A . n 
A 1 393 THR 393 393 393 THR THR A . n 
A 1 394 ALA 394 394 394 ALA ALA A . n 
A 1 395 MET 395 395 395 MET MET A . n 
A 1 396 ALA 396 396 396 ALA ALA A . n 
A 1 397 LEU 397 397 397 LEU LEU A . n 
A 1 398 LEU 398 398 398 LEU LEU A . n 
A 1 399 THR 399 399 399 THR THR A . n 
A 1 400 LYS 400 400 400 LYS LYS A . n 
A 1 401 THR 401 401 401 THR THR A . n 
A 1 402 VAL 402 402 402 VAL VAL A . n 
A 1 403 TYR 403 403 403 TYR TYR A . n 
A 1 404 GLY 404 404 404 GLY GLY A . n 
A 1 405 LEU 405 405 405 LEU LEU A . n 
A 1 406 TRP 406 406 406 TRP TRP A . n 
A 1 407 TYR 407 407 407 TYR TYR A . n 
A 1 408 LEU 408 408 408 LEU LEU A . n 
A 1 409 SER 409 409 409 SER SER A . n 
A 1 410 SER 410 410 410 SER SER A . n 
A 1 411 ASP 411 411 411 ASP ASP A . n 
A 1 412 LEU 412 412 412 LEU LEU A . n 
A 1 413 VAL 413 413 413 VAL VAL A . n 
A 1 414 TYR 414 414 414 TYR TYR A . n 
A 1 415 ILE 415 415 415 ILE ILE A . n 
A 1 416 VAL 416 416 416 VAL VAL A . n 
A 1 417 ILE 417 417 417 ILE ILE A . n 
A 1 418 PHE 418 418 418 PHE PHE A . n 
A 1 419 PRO 419 419 419 PRO PRO A . n 
A 1 420 GLN 420 420 420 GLN GLN A . n 
A 1 421 LEU 421 421 421 LEU LEU A . n 
A 1 422 LEU 422 422 422 LEU LEU A . n 
A 1 423 CYS 423 423 423 CYS CYS A . n 
A 1 424 VAL 424 424 424 VAL VAL A . n 
A 1 425 LEU 425 425 425 LEU LEU A . n 
A 1 426 PHE 426 426 426 PHE PHE A . n 
A 1 427 VAL 427 427 427 VAL VAL A . n 
A 1 428 LYS 428 428 428 LYS LYS A . n 
A 1 429 GLY 429 429 429 GLY GLY A . n 
A 1 430 THR 430 430 430 THR THR A . n 
A 1 431 ASN 431 431 431 ASN ASN A . n 
A 1 432 THR 432 432 432 THR THR A . n 
A 1 433 TYR 433 433 433 TYR TYR A . n 
A 1 434 GLY 434 434 434 GLY GLY A . n 
A 1 435 ALA 435 435 435 ALA ALA A . n 
A 1 436 VAL 436 436 436 VAL VAL A . n 
A 1 437 ALA 437 437 437 ALA ALA A . n 
A 1 438 GLY 438 438 438 GLY GLY A . n 
A 1 439 TYR 439 439 439 TYR TYR A . n 
A 1 440 VAL 440 440 440 VAL VAL A . n 
A 1 441 SER 441 441 441 SER SER A . n 
A 1 442 GLY 442 442 442 GLY GLY A . n 
A 1 443 LEU 443 443 443 LEU LEU A . n 
A 1 444 PHE 444 444 444 PHE PHE A . n 
A 1 445 LEU 445 445 445 LEU LEU A . n 
A 1 446 ARG 446 446 446 ARG ARG A . n 
A 1 447 ILE 447 447 447 ILE ILE A . n 
A 1 448 THR 448 448 448 THR THR A . n 
A 1 449 GLY 449 449 449 GLY GLY A . n 
A 1 450 GLY 450 450 450 GLY GLY A . n 
A 1 451 GLU 451 451 451 GLU GLU A . n 
A 1 452 PRO 452 452 452 PRO PRO A . n 
A 1 453 TYR 453 453 453 TYR TYR A . n 
A 1 454 LEU 454 454 454 LEU LEU A . n 
A 1 455 TYR 455 455 455 TYR TYR A . n 
A 1 456 LEU 456 456 456 LEU LEU A . n 
A 1 457 GLN 457 457 457 GLN GLN A . n 
A 1 458 PRO 458 458 458 PRO PRO A . n 
A 1 459 LEU 459 459 459 LEU LEU A . n 
A 1 460 ILE 460 460 460 ILE ILE A . n 
A 1 461 PHE 461 461 461 PHE PHE A . n 
A 1 462 TYR 462 462 462 TYR TYR A . n 
A 1 463 PRO 463 463 463 PRO PRO A . n 
A 1 464 GLY 464 464 464 GLY GLY A . n 
A 1 465 TYR 465 465 465 TYR TYR A . n 
A 1 466 TYR 466 466 466 TYR TYR A . n 
A 1 467 PRO 467 467 467 PRO PRO A . n 
A 1 468 ASP 468 468 468 ASP ASP A . n 
A 1 469 ASP 469 469 469 ASP ASP A . n 
A 1 470 ASN 470 470 470 ASN ASN A . n 
A 1 471 GLY 471 471 471 GLY GLY A . n 
A 1 472 ILE 472 472 472 ILE ILE A . n 
A 1 473 TYR 473 473 473 TYR TYR A . n 
A 1 474 ASN 474 474 474 ASN ASN A . n 
A 1 475 GLN 475 475 475 GLN GLN A . n 
A 1 476 LYS 476 476 476 LYS LYS A . n 
A 1 477 PHE 477 477 477 PHE PHE A . n 
A 1 478 PRO 478 478 478 PRO PRO A . n 
A 1 479 PHE 479 479 479 PHE PHE A . n 
A 1 480 LYS 480 480 480 LYS LYS A . n 
A 1 481 THR 481 481 481 THR THR A . n 
A 1 482 LEU 482 482 482 LEU LEU A . n 
A 1 483 ALA 483 483 483 ALA ALA A . n 
A 1 484 MET 484 484 484 MET MET A . n 
A 1 485 VAL 485 485 485 VAL VAL A . n 
A 1 486 THR 486 486 486 THR THR A . n 
A 1 487 SER 487 487 487 SER SER A . n 
A 1 488 PHE 488 488 488 PHE PHE A . n 
A 1 489 LEU 489 489 489 LEU LEU A . n 
A 1 490 THR 490 490 490 THR THR A . n 
A 1 491 ASN 491 491 491 ASN ASN A . n 
A 1 492 ILE 492 492 492 ILE ILE A . n 
A 1 493 CYS 493 493 493 CYS CYS A . n 
A 1 494 ILE 494 494 494 ILE ILE A . n 
A 1 495 SER 495 495 495 SER SER A . n 
A 1 496 TYR 496 496 496 TYR TYR A . n 
A 1 497 LEU 497 497 497 LEU LEU A . n 
A 1 498 ALA 498 498 498 ALA ALA A . n 
A 1 499 LYS 499 499 499 LYS LYS A . n 
A 1 500 TYR 500 500 500 TYR TYR A . n 
A 1 501 LEU 501 501 501 LEU LEU A . n 
A 1 502 PHE 502 502 502 PHE PHE A . n 
A 1 503 GLU 503 503 503 GLU GLU A . n 
A 1 504 SER 504 504 504 SER SER A . n 
A 1 505 GLY 505 505 505 GLY GLY A . n 
A 1 506 THR 506 506 506 THR THR A . n 
A 1 507 LEU 507 507 507 LEU LEU A . n 
A 1 508 PRO 508 508 508 PRO PRO A . n 
A 1 509 PRO 509 509 509 PRO PRO A . n 
A 1 510 LYS 510 510 510 LYS LYS A . n 
A 1 511 LEU 511 511 511 LEU LEU A . n 
A 1 512 ASP 512 512 512 ASP ASP A . n 
A 1 513 VAL 513 513 513 VAL VAL A . n 
A 1 514 PHE 514 514 514 PHE PHE A . n 
A 1 515 ASP 515 515 515 ASP ASP A . n 
A 1 516 ALA 516 516 516 ALA ALA A . n 
A 1 517 VAL 517 517 517 VAL VAL A . n 
A 1 518 VAL 518 518 ?   ?   ?   A . n 
A 1 519 ALA 519 519 ?   ?   ?   A . n 
A 1 520 ARG 520 520 ?   ?   ?   A . n 
A 1 521 HIS 521 521 ?   ?   ?   A . n 
A 1 522 SER 522 522 ?   ?   ?   A . n 
A 1 523 GLU 523 523 ?   ?   ?   A . n 
A 1 524 GLU 524 524 ?   ?   ?   A . n 
A 1 525 ASN 525 525 ?   ?   ?   A . n 
A 1 526 MET 526 526 ?   ?   ?   A . n 
A 1 527 ASP 527 527 ?   ?   ?   A . n 
A 1 528 LYS 528 528 ?   ?   ?   A . n 
A 1 529 THR 529 529 ?   ?   ?   A . n 
A 1 530 ILE 530 530 ?   ?   ?   A . n 
A 1 531 LEU 531 531 ?   ?   ?   A . n 
A 1 532 VAL 532 532 ?   ?   ?   A . n 
A 1 533 LYS 533 533 ?   ?   ?   A . n 
A 1 534 ASN 534 534 ?   ?   ?   A . n 
A 1 535 GLU 535 535 ?   ?   ?   A . n 
A 1 536 ASN 536 536 ?   ?   ?   A . n 
A 1 537 ILE 537 537 ?   ?   ?   A . n 
A 1 538 LYS 538 538 ?   ?   ?   A . n 
A 1 539 LEU 539 539 ?   ?   ?   A . n 
A 1 540 ASP 540 540 ?   ?   ?   A . n 
A 1 541 GLU 541 541 ?   ?   ?   A . n 
A 1 542 LEU 542 542 ?   ?   ?   A . n 
A 1 543 ALA 543 543 ?   ?   ?   A . n 
A 1 544 LEU 544 544 ?   ?   ?   A . n 
A 1 545 VAL 545 545 ?   ?   ?   A . n 
A 1 546 LYS 546 546 ?   ?   ?   A . n 
A 1 547 PRO 547 547 ?   ?   ?   A . n 
A 1 548 ARG 548 548 ?   ?   ?   A . n 
A 1 549 GLN 549 549 ?   ?   ?   A . n 
A 1 550 SER 550 550 ?   ?   ?   A . n 
A 1 551 MET 551 551 ?   ?   ?   A . n 
A 1 552 THR 552 552 ?   ?   ?   A . n 
A 1 553 LEU 553 553 ?   ?   ?   A . n 
A 1 554 SER 554 554 ?   ?   ?   A . n 
A 1 555 SER 555 555 ?   ?   ?   A . n 
A 1 556 THR 556 556 ?   ?   ?   A . n 
A 1 557 PHE 557 557 ?   ?   ?   A . n 
A 1 558 THR 558 558 ?   ?   ?   A . n 
A 1 559 ASN 559 559 ?   ?   ?   A . n 
A 1 560 LYS 560 560 ?   ?   ?   A . n 
A 1 561 GLU 561 561 ?   ?   ?   A . n 
A 1 562 ALA 562 562 ?   ?   ?   A . n 
A 1 563 PHE 563 563 ?   ?   ?   A . n 
A 1 564 LEU 564 564 ?   ?   ?   A . n 
A 1 565 ASP 565 565 ?   ?   ?   A . n 
A 1 566 VAL 566 566 ?   ?   ?   A . n 
A 1 567 ASP 567 567 ?   ?   ?   A . n 
A 1 568 SER 568 568 ?   ?   ?   A . n 
A 1 569 SER 569 569 ?   ?   ?   A . n 
A 1 570 PRO 570 570 ?   ?   ?   A . n 
A 1 571 GLU 571 571 ?   ?   ?   A . n 
A 1 572 GLY 572 572 ?   ?   ?   A . n 
A 1 573 SER 573 573 ?   ?   ?   A . n 
A 1 574 GLY 574 574 ?   ?   ?   A . n 
A 1 575 THR 575 575 ?   ?   ?   A . n 
A 1 576 GLU 576 576 ?   ?   ?   A . n 
A 1 577 ASP 577 577 ?   ?   ?   A . n 
A 1 578 ASN 578 578 ?   ?   ?   A . n 
A 1 579 LEU 579 579 ?   ?   ?   A . n 
A 1 580 GLN 580 580 ?   ?   ?   A . n 
A 1 581 ALA 581 581 ?   ?   ?   A . n 
A 1 582 ALA 582 582 ?   ?   ?   A . n 
A 1 583 ALA 583 583 ?   ?   ?   A . n 
A 1 584 GLY 584 584 ?   ?   ?   A . n 
A 1 585 GLY 585 585 ?   ?   ?   A . n 
A 1 586 SER 586 586 ?   ?   ?   A . n 
A 1 587 TRP 587 587 ?   ?   ?   A . n 
A 1 588 SER 588 588 ?   ?   ?   A . n 
A 1 589 HIS 589 589 ?   ?   ?   A . n 
A 1 590 PRO 590 590 ?   ?   ?   A . n 
A 1 591 GLN 591 591 ?   ?   ?   A . n 
A 1 592 PHE 592 592 ?   ?   ?   A . n 
A 1 593 GLU 593 593 ?   ?   ?   A . n 
A 1 594 LYS 594 594 ?   ?   ?   A . n 
A 1 595 GLY 595 595 ?   ?   ?   A . n 
A 1 596 GLY 596 596 ?   ?   ?   A . n 
A 1 597 GLY 597 597 ?   ?   ?   A . n 
A 1 598 SER 598 598 ?   ?   ?   A . n 
A 1 599 GLY 599 599 ?   ?   ?   A . n 
A 1 600 GLY 600 600 ?   ?   ?   A . n 
A 1 601 GLY 601 601 ?   ?   ?   A . n 
A 1 602 SER 602 602 ?   ?   ?   A . n 
A 1 603 GLY 603 603 ?   ?   ?   A . n 
A 1 604 GLY 604 604 ?   ?   ?   A . n 
A 1 605 SER 605 605 ?   ?   ?   A . n 
A 1 606 ALA 606 606 ?   ?   ?   A . n 
A 1 607 TRP 607 607 ?   ?   ?   A . n 
A 1 608 SER 608 608 ?   ?   ?   A . n 
A 1 609 HIS 609 609 ?   ?   ?   A . n 
A 1 610 PRO 610 610 ?   ?   ?   A . n 
A 1 611 GLN 611 611 ?   ?   ?   A . n 
A 1 612 PHE 612 612 ?   ?   ?   A . n 
A 1 613 GLU 613 613 ?   ?   ?   A . n 
A 1 614 LYS 614 614 ?   ?   ?   A . n 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BFI 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BFI 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BFI 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9BFI 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            . 
_refine.ls_d_res_low                             ? 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.003 ? 3874 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.655 ? 5293 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 4.398 ? 523  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.040 ? 617  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.007 ? 640  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     9BFI 
_struct.title                        'Cryo-EM structure of human CHT1 in the apo inward-open state' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BFI 
_struct_keywords.text            'Choline transporter, TRANSPORT PROTEIN' 
_struct_keywords.pdbx_keywords   'TRANSPORT PROTEIN' 
# 
_struct_asym.id                            A 
_struct_asym.pdbx_blank_PDB_chainid_flag   N 
_struct_asym.pdbx_modified                 N 
_struct_asym.entity_id                     1 
_struct_asym.details                       ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    SC5A7_HUMAN 
_struct_ref.pdbx_db_accession          Q9GZV3 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MAFHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYVPGY
GLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVD
MHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSW
LDSFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDPKTTEEADMIL
PIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTK
TVYGLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIFYPGYYPDDNGIYNQKFPFK
TLAMVTSFLTNICISYLAKYLFESGTLPPKLDVFDAVVARHSEENMDKTILVKNENIKLDELALVKPRQSMTLSSTFTNK
EAFLDVDSSPEGSGTEDNLQ
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9BFI 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 580 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q9GZV3 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  580 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       580 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9BFI ALA A 581 ? UNP Q9GZV3 ? ? 'expression tag' 581 1  
1 9BFI ALA A 582 ? UNP Q9GZV3 ? ? 'expression tag' 582 2  
1 9BFI ALA A 583 ? UNP Q9GZV3 ? ? 'expression tag' 583 3  
1 9BFI GLY A 584 ? UNP Q9GZV3 ? ? 'expression tag' 584 4  
1 9BFI GLY A 585 ? UNP Q9GZV3 ? ? 'expression tag' 585 5  
1 9BFI SER A 586 ? UNP Q9GZV3 ? ? 'expression tag' 586 6  
1 9BFI TRP A 587 ? UNP Q9GZV3 ? ? 'expression tag' 587 7  
1 9BFI SER A 588 ? UNP Q9GZV3 ? ? 'expression tag' 588 8  
1 9BFI HIS A 589 ? UNP Q9GZV3 ? ? 'expression tag' 589 9  
1 9BFI PRO A 590 ? UNP Q9GZV3 ? ? 'expression tag' 590 10 
1 9BFI GLN A 591 ? UNP Q9GZV3 ? ? 'expression tag' 591 11 
1 9BFI PHE A 592 ? UNP Q9GZV3 ? ? 'expression tag' 592 12 
1 9BFI GLU A 593 ? UNP Q9GZV3 ? ? 'expression tag' 593 13 
1 9BFI LYS A 594 ? UNP Q9GZV3 ? ? 'expression tag' 594 14 
1 9BFI GLY A 595 ? UNP Q9GZV3 ? ? 'expression tag' 595 15 
1 9BFI GLY A 596 ? UNP Q9GZV3 ? ? 'expression tag' 596 16 
1 9BFI GLY A 597 ? UNP Q9GZV3 ? ? 'expression tag' 597 17 
1 9BFI SER A 598 ? UNP Q9GZV3 ? ? 'expression tag' 598 18 
1 9BFI GLY A 599 ? UNP Q9GZV3 ? ? 'expression tag' 599 19 
1 9BFI GLY A 600 ? UNP Q9GZV3 ? ? 'expression tag' 600 20 
1 9BFI GLY A 601 ? UNP Q9GZV3 ? ? 'expression tag' 601 21 
1 9BFI SER A 602 ? UNP Q9GZV3 ? ? 'expression tag' 602 22 
1 9BFI GLY A 603 ? UNP Q9GZV3 ? ? 'expression tag' 603 23 
1 9BFI GLY A 604 ? UNP Q9GZV3 ? ? 'expression tag' 604 24 
1 9BFI SER A 605 ? UNP Q9GZV3 ? ? 'expression tag' 605 25 
1 9BFI ALA A 606 ? UNP Q9GZV3 ? ? 'expression tag' 606 26 
1 9BFI TRP A 607 ? UNP Q9GZV3 ? ? 'expression tag' 607 27 
1 9BFI SER A 608 ? UNP Q9GZV3 ? ? 'expression tag' 608 28 
1 9BFI HIS A 609 ? UNP Q9GZV3 ? ? 'expression tag' 609 29 
1 9BFI PRO A 610 ? UNP Q9GZV3 ? ? 'expression tag' 610 30 
1 9BFI GLN A 611 ? UNP Q9GZV3 ? ? 'expression tag' 611 31 
1 9BFI PHE A 612 ? UNP Q9GZV3 ? ? 'expression tag' 612 32 
1 9BFI GLU A 613 ? UNP Q9GZV3 ? ? 'expression tag' 613 33 
1 9BFI LYS A 614 ? UNP Q9GZV3 ? ? 'expression tag' 614 34 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'gel filtration' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 HIS A 4   ? THR A 29  ? HIS A 4   THR A 29  1 ? 26 
HELX_P HELX_P2  AA2 ILE A 49  ? VAL A 63  ? ILE A 49  VAL A 63  1 ? 15 
HELX_P HELX_P3  AA3 GLY A 64  ? VAL A 77  ? GLY A 64  VAL A 77  1 ? 14 
HELX_P HELX_P4  AA4 ALA A 85  ? PHE A 102 ? ALA A 85  PHE A 102 1 ? 18 
HELX_P HELX_P5  AA5 PHE A 102 ? LYS A 109 ? PHE A 102 LYS A 109 1 ? 8  
HELX_P HELX_P6  AA6 LEU A 115 ? TYR A 122 ? LEU A 115 TYR A 122 1 ? 8  
HELX_P HELX_P7  AA7 GLY A 123 ? ILE A 157 ? GLY A 123 ILE A 157 1 ? 35 
HELX_P HELX_P8  AA8 ASP A 160 ? GLY A 179 ? ASP A 160 GLY A 179 1 ? 20 
HELX_P HELX_P9  AA9 TYR A 186 ? ILE A 201 ? TYR A 186 ILE A 201 1 ? 16 
HELX_P HELX_P10 AB1 SER A 202 ? SER A 208 ? SER A 202 SER A 208 1 ? 7  
HELX_P HELX_P11 AB2 ASP A 214 ? HIS A 221 ? ASP A 214 HIS A 221 1 ? 8  
HELX_P HELX_P12 AB3 GLU A 236 ? GLY A 251 ? GLU A 236 GLY A 251 1 ? 16 
HELX_P HELX_P13 AB4 TRP A 254 ? SER A 264 ? TRP A 254 SER A 264 1 ? 11 
HELX_P HELX_P14 AB5 SER A 266 ? THR A 298 ? SER A 266 THR A 298 1 ? 33 
HELX_P HELX_P15 AB6 GLU A 315 ? ASP A 317 ? GLU A 315 ASP A 317 5 ? 3  
HELX_P HELX_P16 AB7 MET A 318 ? LEU A 327 ? MET A 318 LEU A 327 1 ? 10 
HELX_P HELX_P17 AB8 PRO A 329 ? ILE A 363 ? PRO A 329 ILE A 363 1 ? 35 
HELX_P HELX_P18 AB9 ILE A 377 ? THR A 399 ? ILE A 377 THR A 399 1 ? 23 
HELX_P HELX_P19 AC1 VAL A 402 ? PHE A 426 ? VAL A 402 PHE A 426 1 ? 25 
HELX_P HELX_P20 AC2 ASN A 431 ? GLY A 450 ? ASN A 431 GLY A 450 1 ? 20 
HELX_P HELX_P21 AC3 PRO A 478 ? GLY A 505 ? PRO A 478 GLY A 505 1 ? 28 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          LEU 
_struct_mon_prot_cis.label_seq_id           307 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           LEU 
_struct_mon_prot_cis.auth_seq_id            307 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    308 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     308 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       2.48 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   2 
_struct_sheet.details          ? 
# 
_struct_sheet_order.sheet_id     AA1 
_struct_sheet_order.range_id_1   1 
_struct_sheet_order.range_id_2   2 
_struct_sheet_order.offset       ? 
_struct_sheet_order.sense        anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 TYR A 466 ? PRO A 467 ? TYR A 466 PRO A 467 
AA1 2 TYR A 473 ? ASN A 474 ? TYR A 473 ASN A 474 
# 
_pdbx_struct_sheet_hbond.sheet_id                AA1 
_pdbx_struct_sheet_hbond.range_id_1              1 
_pdbx_struct_sheet_hbond.range_id_2              2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id   N 
_pdbx_struct_sheet_hbond.range_1_label_comp_id   TYR 
_pdbx_struct_sheet_hbond.range_1_label_asym_id   A 
_pdbx_struct_sheet_hbond.range_1_label_seq_id    466 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code    ? 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id    N 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id    TYR 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id    A 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id     466 
_pdbx_struct_sheet_hbond.range_2_label_atom_id   O 
_pdbx_struct_sheet_hbond.range_2_label_comp_id   ASN 
_pdbx_struct_sheet_hbond.range_2_label_asym_id   A 
_pdbx_struct_sheet_hbond.range_2_label_seq_id    474 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code    ? 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id    O 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id    ASN 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id    A 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id     474 
# 
_pdbx_entry_details.entry_id                   9BFI 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 TYR A 80  ? ? -94.26 -61.68 
2 1 ILE A 363 ? ? -93.77 -60.98 
3 1 VAL A 416 ? ? -98.86 -60.04 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9BFI 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9BFI 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  2.66 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               334330 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.4 
# 
loop_
_em_entity_assembly.id 
_em_entity_assembly.parent_id 
_em_entity_assembly.source 
_em_entity_assembly.type 
_em_entity_assembly.name 
_em_entity_assembly.details 
_em_entity_assembly.synonym 
_em_entity_assembly.oligomeric_details 
_em_entity_assembly.entity_id_list 
1 0 'MULTIPLE SOURCES' CELL                              'human CHT1 in te apo state'  ? ? ? 1 
2 1 RECOMBINANT        'ORGANELLE OR CELLULAR COMPONENT' 'human CHT1 in the apo state' ? ? ? 1 
# 
_em_imaging.entry_id                        9BFI 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             1800 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              9BFI 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9BFI 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET 1   ? A MET 1   
2   1 Y 1 A LYS 30  ? A LYS 30  
3   1 Y 1 A ASN 31  ? A ASN 31  
4   1 Y 1 A SER 32  ? A SER 32  
5   1 Y 1 A GLY 33  ? A GLY 33  
6   1 Y 1 A SER 34  ? A SER 34  
7   1 Y 1 A ALA 35  ? A ALA 35  
8   1 Y 1 A GLU 36  ? A GLU 36  
9   1 Y 1 A GLU 37  ? A GLU 37  
10  1 Y 1 A ARG 38  ? A ARG 38  
11  1 Y 1 A SER 39  ? A SER 39  
12  1 Y 1 A GLU 40  ? A GLU 40  
13  1 Y 1 A ALA 41  ? A ALA 41  
14  1 Y 1 A ILE 42  ? A ILE 42  
15  1 Y 1 A ILE 43  ? A ILE 43  
16  1 Y 1 A VAL 44  ? A VAL 44  
17  1 Y 1 A GLY 45  ? A GLY 45  
18  1 Y 1 A GLY 46  ? A GLY 46  
19  1 Y 1 A GLY 180 ? A GLY 180 
20  1 Y 1 A LEU 181 ? A LEU 181 
21  1 Y 1 A TYR 182 ? A TYR 182 
22  1 Y 1 A ARG 369 ? A ARG 369 
23  1 Y 1 A GLN 370 ? A GLN 370 
24  1 Y 1 A ASN 371 ? A ASN 371 
25  1 Y 1 A ALA 372 ? A ALA 372 
26  1 Y 1 A SER 373 ? A SER 373 
27  1 Y 1 A ASP 374 ? A ASP 374 
28  1 Y 1 A LYS 375 ? A LYS 375 
29  1 Y 1 A VAL 518 ? A VAL 518 
30  1 Y 1 A ALA 519 ? A ALA 519 
31  1 Y 1 A ARG 520 ? A ARG 520 
32  1 Y 1 A HIS 521 ? A HIS 521 
33  1 Y 1 A SER 522 ? A SER 522 
34  1 Y 1 A GLU 523 ? A GLU 523 
35  1 Y 1 A GLU 524 ? A GLU 524 
36  1 Y 1 A ASN 525 ? A ASN 525 
37  1 Y 1 A MET 526 ? A MET 526 
38  1 Y 1 A ASP 527 ? A ASP 527 
39  1 Y 1 A LYS 528 ? A LYS 528 
40  1 Y 1 A THR 529 ? A THR 529 
41  1 Y 1 A ILE 530 ? A ILE 530 
42  1 Y 1 A LEU 531 ? A LEU 531 
43  1 Y 1 A VAL 532 ? A VAL 532 
44  1 Y 1 A LYS 533 ? A LYS 533 
45  1 Y 1 A ASN 534 ? A ASN 534 
46  1 Y 1 A GLU 535 ? A GLU 535 
47  1 Y 1 A ASN 536 ? A ASN 536 
48  1 Y 1 A ILE 537 ? A ILE 537 
49  1 Y 1 A LYS 538 ? A LYS 538 
50  1 Y 1 A LEU 539 ? A LEU 539 
51  1 Y 1 A ASP 540 ? A ASP 540 
52  1 Y 1 A GLU 541 ? A GLU 541 
53  1 Y 1 A LEU 542 ? A LEU 542 
54  1 Y 1 A ALA 543 ? A ALA 543 
55  1 Y 1 A LEU 544 ? A LEU 544 
56  1 Y 1 A VAL 545 ? A VAL 545 
57  1 Y 1 A LYS 546 ? A LYS 546 
58  1 Y 1 A PRO 547 ? A PRO 547 
59  1 Y 1 A ARG 548 ? A ARG 548 
60  1 Y 1 A GLN 549 ? A GLN 549 
61  1 Y 1 A SER 550 ? A SER 550 
62  1 Y 1 A MET 551 ? A MET 551 
63  1 Y 1 A THR 552 ? A THR 552 
64  1 Y 1 A LEU 553 ? A LEU 553 
65  1 Y 1 A SER 554 ? A SER 554 
66  1 Y 1 A SER 555 ? A SER 555 
67  1 Y 1 A THR 556 ? A THR 556 
68  1 Y 1 A PHE 557 ? A PHE 557 
69  1 Y 1 A THR 558 ? A THR 558 
70  1 Y 1 A ASN 559 ? A ASN 559 
71  1 Y 1 A LYS 560 ? A LYS 560 
72  1 Y 1 A GLU 561 ? A GLU 561 
73  1 Y 1 A ALA 562 ? A ALA 562 
74  1 Y 1 A PHE 563 ? A PHE 563 
75  1 Y 1 A LEU 564 ? A LEU 564 
76  1 Y 1 A ASP 565 ? A ASP 565 
77  1 Y 1 A VAL 566 ? A VAL 566 
78  1 Y 1 A ASP 567 ? A ASP 567 
79  1 Y 1 A SER 568 ? A SER 568 
80  1 Y 1 A SER 569 ? A SER 569 
81  1 Y 1 A PRO 570 ? A PRO 570 
82  1 Y 1 A GLU 571 ? A GLU 571 
83  1 Y 1 A GLY 572 ? A GLY 572 
84  1 Y 1 A SER 573 ? A SER 573 
85  1 Y 1 A GLY 574 ? A GLY 574 
86  1 Y 1 A THR 575 ? A THR 575 
87  1 Y 1 A GLU 576 ? A GLU 576 
88  1 Y 1 A ASP 577 ? A ASP 577 
89  1 Y 1 A ASN 578 ? A ASN 578 
90  1 Y 1 A LEU 579 ? A LEU 579 
91  1 Y 1 A GLN 580 ? A GLN 580 
92  1 Y 1 A ALA 581 ? A ALA 581 
93  1 Y 1 A ALA 582 ? A ALA 582 
94  1 Y 1 A ALA 583 ? A ALA 583 
95  1 Y 1 A GLY 584 ? A GLY 584 
96  1 Y 1 A GLY 585 ? A GLY 585 
97  1 Y 1 A SER 586 ? A SER 586 
98  1 Y 1 A TRP 587 ? A TRP 587 
99  1 Y 1 A SER 588 ? A SER 588 
100 1 Y 1 A HIS 589 ? A HIS 589 
101 1 Y 1 A PRO 590 ? A PRO 590 
102 1 Y 1 A GLN 591 ? A GLN 591 
103 1 Y 1 A PHE 592 ? A PHE 592 
104 1 Y 1 A GLU 593 ? A GLU 593 
105 1 Y 1 A LYS 594 ? A LYS 594 
106 1 Y 1 A GLY 595 ? A GLY 595 
107 1 Y 1 A GLY 596 ? A GLY 596 
108 1 Y 1 A GLY 597 ? A GLY 597 
109 1 Y 1 A SER 598 ? A SER 598 
110 1 Y 1 A GLY 599 ? A GLY 599 
111 1 Y 1 A GLY 600 ? A GLY 600 
112 1 Y 1 A GLY 601 ? A GLY 601 
113 1 Y 1 A SER 602 ? A SER 602 
114 1 Y 1 A GLY 603 ? A GLY 603 
115 1 Y 1 A GLY 604 ? A GLY 604 
116 1 Y 1 A SER 605 ? A SER 605 
117 1 Y 1 A ALA 606 ? A ALA 606 
118 1 Y 1 A TRP 607 ? A TRP 607 
119 1 Y 1 A SER 608 ? A SER 608 
120 1 Y 1 A HIS 609 ? A HIS 609 
121 1 Y 1 A PRO 610 ? A PRO 610 
122 1 Y 1 A GLN 611 ? A GLN 611 
123 1 Y 1 A PHE 612 ? A PHE 612 
124 1 Y 1 A GLU 613 ? A GLU 613 
125 1 Y 1 A LYS 614 ? A LYS 614 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-04-17 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           9BFI 
_em_admin.last_update        2025-01-15 
_em_admin.map_release_date   2024-11-06 
_em_admin.title              'Cryo-EM structure of human CHT1 in the apo inward-open state' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   2 
_em_entity_assembly_naturalsource.id                   1 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   2 
_em_entity_assembly_recombinant.id                   1 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         60 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'FEI FALCON IV (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'             ? 2  ? ? 1 ? ? 
MASKING                         ? 3  ? ? ? ? ? 
'CTF CORRECTION'                ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'            ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'          ? 6  ? ? ? ? ? 
'MODEL FITTING'                 ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'              ? 8  ? ? ? ? ? 
OTHER                           ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? ? ? 
CLASSIFICATION                  ? 12 1 ? ? ? ? 
RECONSTRUCTION                  ? 13 1 ? ? ? ? 
'VOLUME SELECTION'              ? 14 1 1 1 ? ? 
'SERIES ALIGNMENT'              ? 15 1 1 1 ? ? 
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ? ? 
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ? ? 
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ? ? 
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' R35GM140892 1 
'Welch Foundation'                                                                         'United States' I-1578      2 
'Howard Hughes Medical Institute (HHMI)'                                                   'United States' ?           3 
# 
_atom_sites.entry_id                    9BFI 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . ALA A 1 2   ? 84.459  62.778  72.107  1.00 72.42  ? 2   ALA A N   1 
ATOM 2    C CA  . ALA A 1 2   ? 84.658  64.197  72.379  1.00 72.42  ? 2   ALA A CA  1 
ATOM 3    C C   . ALA A 1 2   ? 85.343  64.404  73.725  1.00 72.42  ? 2   ALA A C   1 
ATOM 4    O O   . ALA A 1 2   ? 86.238  65.238  73.850  1.00 72.42  ? 2   ALA A O   1 
ATOM 5    C CB  . ALA A 1 2   ? 83.330  64.936  72.340  1.00 72.42  ? 2   ALA A CB  1 
ATOM 6    N N   . PHE A 1 3   ? 84.906  63.644  74.728  1.00 71.26  ? 3   PHE A N   1 
ATOM 7    C CA  . PHE A 1 3   ? 85.502  63.714  76.056  1.00 71.26  ? 3   PHE A CA  1 
ATOM 8    C C   . PHE A 1 3   ? 86.968  63.305  76.017  1.00 71.26  ? 3   PHE A C   1 
ATOM 9    O O   . PHE A 1 3   ? 87.323  62.265  75.457  1.00 71.26  ? 3   PHE A O   1 
ATOM 10   C CB  . PHE A 1 3   ? 84.728  62.808  77.016  1.00 71.26  ? 3   PHE A CB  1 
ATOM 11   C CG  . PHE A 1 3   ? 85.115  62.973  78.457  1.00 71.26  ? 3   PHE A CG  1 
ATOM 12   C CD1 . PHE A 1 3   ? 85.702  61.927  79.151  1.00 71.26  ? 3   PHE A CD1 1 
ATOM 13   C CD2 . PHE A 1 3   ? 84.886  64.165  79.121  1.00 71.26  ? 3   PHE A CD2 1 
ATOM 14   C CE1 . PHE A 1 3   ? 86.059  62.070  80.478  1.00 71.26  ? 3   PHE A CE1 1 
ATOM 15   C CE2 . PHE A 1 3   ? 85.240  64.312  80.449  1.00 71.26  ? 3   PHE A CE2 1 
ATOM 16   C CZ  . PHE A 1 3   ? 85.828  63.264  81.127  1.00 71.26  ? 3   PHE A CZ  1 
ATOM 17   N N   . HIS A 1 4   ? 87.819  64.132  76.617  1.00 69.67  ? 4   HIS A N   1 
ATOM 18   C CA  . HIS A 1 4   ? 89.245  63.859  76.721  1.00 69.67  ? 4   HIS A CA  1 
ATOM 19   C C   . HIS A 1 4   ? 89.594  63.586  78.177  1.00 69.67  ? 4   HIS A C   1 
ATOM 20   O O   . HIS A 1 4   ? 89.366  64.436  79.044  1.00 69.67  ? 4   HIS A O   1 
ATOM 21   C CB  . HIS A 1 4   ? 90.076  65.028  76.186  1.00 69.67  ? 4   HIS A CB  1 
ATOM 22   C CG  . HIS A 1 4   ? 89.857  65.310  74.732  1.00 69.67  ? 4   HIS A CG  1 
ATOM 23   N ND1 . HIS A 1 4   ? 89.581  64.319  73.815  1.00 69.67  ? 4   HIS A ND1 1 
ATOM 24   C CD2 . HIS A 1 4   ? 89.883  66.471  74.036  1.00 69.67  ? 4   HIS A CD2 1 
ATOM 25   C CE1 . HIS A 1 4   ? 89.439  64.858  72.617  1.00 69.67  ? 4   HIS A CE1 1 
ATOM 26   N NE2 . HIS A 1 4   ? 89.619  66.162  72.723  1.00 69.67  ? 4   HIS A NE2 1 
ATOM 27   N N   . VAL A 1 5   ? 90.142  62.400  78.437  1.00 69.31  ? 5   VAL A N   1 
ATOM 28   C CA  . VAL A 1 5   ? 90.517  62.026  79.797  1.00 69.31  ? 5   VAL A CA  1 
ATOM 29   C C   . VAL A 1 5   ? 91.744  62.807  80.252  1.00 69.31  ? 5   VAL A C   1 
ATOM 30   O O   . VAL A 1 5   ? 91.818  63.258  81.401  1.00 69.31  ? 5   VAL A O   1 
ATOM 31   C CB  . VAL A 1 5   ? 90.746  60.505  79.879  1.00 69.31  ? 5   VAL A CB  1 
ATOM 32   C CG1 . VAL A 1 5   ? 91.217  60.100  81.269  1.00 69.31  ? 5   VAL A CG1 1 
ATOM 33   C CG2 . VAL A 1 5   ? 89.475  59.759  79.503  1.00 69.31  ? 5   VAL A CG2 1 
ATOM 34   N N   . GLU A 1 6   ? 92.713  62.992  79.348  1.00 69.73  ? 6   GLU A N   1 
ATOM 35   C CA  . GLU A 1 6   ? 93.995  63.584  79.722  1.00 69.73  ? 6   GLU A CA  1 
ATOM 36   C C   . GLU A 1 6   ? 93.842  65.032  80.181  1.00 69.73  ? 6   GLU A C   1 
ATOM 37   O O   . GLU A 1 6   ? 94.562  65.479  81.081  1.00 69.73  ? 6   GLU A O   1 
ATOM 38   C CB  . GLU A 1 6   ? 94.983  63.469  78.557  1.00 69.73  ? 6   GLU A CB  1 
ATOM 39   C CG  . GLU A 1 6   ? 94.617  64.262  77.309  1.00 69.73  ? 6   GLU A CG  1 
ATOM 40   C CD  . GLU A 1 6   ? 95.599  64.053  76.174  1.00 69.73  ? 6   GLU A CD  1 
ATOM 41   O OE1 . GLU A 1 6   ? 96.557  63.271  76.351  1.00 69.73  ? 6   GLU A OE1 1 
ATOM 42   O OE2 . GLU A 1 6   ? 95.411  64.667  75.103  1.00 69.73  ? 6   GLU A OE2 1 
ATOM 43   N N   . GLY A 1 7   ? 92.903  65.776  79.592  1.00 63.51  ? 7   GLY A N   1 
ATOM 44   C CA  . GLY A 1 7   ? 92.656  67.133  80.057  1.00 63.51  ? 7   GLY A CA  1 
ATOM 45   C C   . GLY A 1 7   ? 92.123  67.167  81.475  1.00 63.51  ? 7   GLY A C   1 
ATOM 46   O O   . GLY A 1 7   ? 92.553  67.983  82.298  1.00 63.51  ? 7   GLY A O   1 
ATOM 47   N N   . LEU A 1 8   ? 91.182  66.270  81.783  1.00 60.11  ? 8   LEU A N   1 
ATOM 48   C CA  . LEU A 1 8   ? 90.651  66.180  83.138  1.00 60.11  ? 8   LEU A CA  1 
ATOM 49   C C   . LEU A 1 8   ? 91.732  65.760  84.125  1.00 60.11  ? 8   LEU A C   1 
ATOM 50   O O   . LEU A 1 8   ? 91.783  66.266  85.253  1.00 60.11  ? 8   LEU A O   1 
ATOM 51   C CB  . LEU A 1 8   ? 89.477  65.202  83.175  1.00 60.11  ? 8   LEU A CB  1 
ATOM 52   C CG  . LEU A 1 8   ? 88.768  65.042  84.521  1.00 60.11  ? 8   LEU A CG  1 
ATOM 53   C CD1 . LEU A 1 8   ? 88.143  66.357  84.956  1.00 60.11  ? 8   LEU A CD1 1 
ATOM 54   C CD2 . LEU A 1 8   ? 87.720  63.945  84.447  1.00 60.11  ? 8   LEU A CD2 1 
ATOM 55   N N   . ILE A 1 9   ? 92.610  64.840  83.713  1.00 59.29  ? 9   ILE A N   1 
ATOM 56   C CA  . ILE A 1 9   ? 93.729  64.436  84.562  1.00 59.29  ? 9   ILE A CA  1 
ATOM 57   C C   . ILE A 1 9   ? 94.657  65.618  84.816  1.00 59.29  ? 9   ILE A C   1 
ATOM 58   O O   . ILE A 1 9   ? 95.154  65.807  85.930  1.00 59.29  ? 9   ILE A O   1 
ATOM 59   C CB  . ILE A 1 9   ? 94.480  63.244  83.937  1.00 59.29  ? 9   ILE A CB  1 
ATOM 60   C CG1 . ILE A 1 9   ? 93.551  62.037  83.800  1.00 59.29  ? 9   ILE A CG1 1 
ATOM 61   C CG2 . ILE A 1 9   ? 95.699  62.869  84.767  1.00 59.29  ? 9   ILE A CG2 1 
ATOM 62   C CD1 . ILE A 1 9   ? 93.006  61.533  85.117  1.00 59.29  ? 9   ILE A CD1 1 
ATOM 63   N N   . ALA A 1 10  ? 94.900  66.433  83.785  1.00 55.37  ? 10  ALA A N   1 
ATOM 64   C CA  . ALA A 1 10  ? 95.742  67.616  83.944  1.00 55.37  ? 10  ALA A CA  1 
ATOM 65   C C   . ALA A 1 10  ? 95.144  68.597  84.947  1.00 55.37  ? 10  ALA A C   1 
ATOM 66   O O   . ALA A 1 10  ? 95.847  69.099  85.836  1.00 55.37  ? 10  ALA A O   1 
ATOM 67   C CB  . ALA A 1 10  ? 95.948  68.296  82.591  1.00 55.37  ? 10  ALA A CB  1 
ATOM 68   N N   . ILE A 1 11  ? 93.839  68.871  84.823  1.00 54.33  ? 11  ILE A N   1 
ATOM 69   C CA  . ILE A 1 11  ? 93.182  69.771  85.773  1.00 54.33  ? 11  ILE A CA  1 
ATOM 70   C C   . ILE A 1 11  ? 93.254  69.205  87.182  1.00 54.33  ? 11  ILE A C   1 
ATOM 71   O O   . ILE A 1 11  ? 93.549  69.929  88.138  1.00 54.33  ? 11  ILE A O   1 
ATOM 72   C CB  . ILE A 1 11  ? 91.720  70.046  85.381  1.00 54.33  ? 11  ILE A CB  1 
ATOM 73   C CG1 . ILE A 1 11  ? 91.590  70.473  83.929  1.00 54.33  ? 11  ILE A CG1 1 
ATOM 74   C CG2 . ILE A 1 11  ? 91.135  71.127  86.265  1.00 54.33  ? 11  ILE A CG2 1 
ATOM 75   C CD1 . ILE A 1 11  ? 90.190  70.273  83.408  1.00 54.33  ? 11  ILE A CD1 1 
ATOM 76   N N   . ILE A 1 12  ? 92.982  67.906  87.333  1.00 55.52  ? 12  ILE A N   1 
ATOM 77   C CA  . ILE A 1 12  ? 92.962  67.294  88.657  1.00 55.52  ? 12  ILE A CA  1 
ATOM 78   C C   . ILE A 1 12  ? 94.348  67.331  89.290  1.00 55.52  ? 12  ILE A C   1 
ATOM 79   O O   . ILE A 1 12  ? 94.493  67.682  90.465  1.00 55.52  ? 12  ILE A O   1 
ATOM 80   C CB  . ILE A 1 12  ? 92.404  65.860  88.566  1.00 55.52  ? 12  ILE A CB  1 
ATOM 81   C CG1 . ILE A 1 12  ? 90.883  65.897  88.417  1.00 55.52  ? 12  ILE A CG1 1 
ATOM 82   C CG2 . ILE A 1 12  ? 92.788  65.043  89.791  1.00 55.52  ? 12  ILE A CG2 1 
ATOM 83   C CD1 . ILE A 1 12  ? 90.242  64.530  88.345  1.00 55.52  ? 12  ILE A CD1 1 
ATOM 84   N N   . VAL A 1 13  ? 95.388  67.012  88.516  1.00 56.23  ? 13  VAL A N   1 
ATOM 85   C CA  . VAL A 1 13  ? 96.747  66.985  89.053  1.00 56.23  ? 13  VAL A CA  1 
ATOM 86   C C   . VAL A 1 13  ? 97.205  68.387  89.437  1.00 56.23  ? 13  VAL A C   1 
ATOM 87   O O   . VAL A 1 13  ? 97.778  68.590  90.514  1.00 56.23  ? 13  VAL A O   1 
ATOM 88   C CB  . VAL A 1 13  ? 97.708  66.322  88.049  1.00 56.23  ? 13  VAL A CB  1 
ATOM 89   C CG1 . VAL A 1 13  ? 99.154  66.551  88.453  1.00 56.23  ? 13  VAL A CG1 1 
ATOM 90   C CG2 . VAL A 1 13  ? 97.436  64.830  87.971  1.00 56.23  ? 13  VAL A CG2 1 
ATOM 91   N N   . PHE A 1 14  ? 96.946  69.382  88.581  1.00 54.42  ? 14  PHE A N   1 
ATOM 92   C CA  . PHE A 1 14  ? 97.379  70.739  88.906  1.00 54.42  ? 14  PHE A CA  1 
ATOM 93   C C   . PHE A 1 14  ? 96.589  71.311  90.080  1.00 54.42  ? 14  PHE A C   1 
ATOM 94   O O   . PHE A 1 14  ? 97.152  72.010  90.933  1.00 54.42  ? 14  PHE A O   1 
ATOM 95   C CB  . PHE A 1 14  ? 97.260  71.638  87.677  1.00 54.42  ? 14  PHE A CB  1 
ATOM 96   C CG  . PHE A 1 14  ? 98.485  71.636  86.810  1.00 54.42  ? 14  PHE A CG  1 
ATOM 97   C CD1 . PHE A 1 14  ? 99.589  72.395  87.151  1.00 54.42  ? 14  PHE A CD1 1 
ATOM 98   C CD2 . PHE A 1 14  ? 98.534  70.869  85.659  1.00 54.42  ? 14  PHE A CD2 1 
ATOM 99   C CE1 . PHE A 1 14  ? 100.719 72.391  86.358  1.00 54.42  ? 14  PHE A CE1 1 
ATOM 100  C CE2 . PHE A 1 14  ? 99.659  70.863  84.862  1.00 54.42  ? 14  PHE A CE2 1 
ATOM 101  C CZ  . PHE A 1 14  ? 100.753 71.624  85.213  1.00 54.42  ? 14  PHE A CZ  1 
ATOM 102  N N   . TYR A 1 15  ? 95.289  71.011  90.152  1.00 57.19  ? 15  TYR A N   1 
ATOM 103  C CA  . TYR A 1 15  ? 94.475  71.445  91.282  1.00 57.19  ? 15  TYR A CA  1 
ATOM 104  C C   . TYR A 1 15  ? 94.951  70.809  92.580  1.00 57.19  ? 15  TYR A C   1 
ATOM 105  O O   . TYR A 1 15  ? 95.036  71.481  93.615  1.00 57.19  ? 15  TYR A O   1 
ATOM 106  C CB  . TYR A 1 15  ? 93.009  71.103  91.016  1.00 57.19  ? 15  TYR A CB  1 
ATOM 107  C CG  . TYR A 1 15  ? 92.017  71.795  91.921  1.00 57.19  ? 15  TYR A CG  1 
ATOM 108  C CD1 . TYR A 1 15  ? 91.788  73.160  91.818  1.00 57.19  ? 15  TYR A CD1 1 
ATOM 109  C CD2 . TYR A 1 15  ? 91.296  71.080  92.868  1.00 57.19  ? 15  TYR A CD2 1 
ATOM 110  C CE1 . TYR A 1 15  ? 90.877  73.795  92.637  1.00 57.19  ? 15  TYR A CE1 1 
ATOM 111  C CE2 . TYR A 1 15  ? 90.383  71.707  93.693  1.00 57.19  ? 15  TYR A CE2 1 
ATOM 112  C CZ  . TYR A 1 15  ? 90.178  73.064  93.573  1.00 57.19  ? 15  TYR A CZ  1 
ATOM 113  O OH  . TYR A 1 15  ? 89.270  73.695  94.391  1.00 57.19  ? 15  TYR A OH  1 
ATOM 114  N N   . LEU A 1 16  ? 95.279  69.514  92.542  1.00 61.88  ? 16  LEU A N   1 
ATOM 115  C CA  . LEU A 1 16  ? 95.797  68.837  93.726  1.00 61.88  ? 16  LEU A CA  1 
ATOM 116  C C   . LEU A 1 16  ? 97.155  69.392  94.130  1.00 61.88  ? 16  LEU A C   1 
ATOM 117  O O   . LEU A 1 16  ? 97.453  69.505  95.320  1.00 61.88  ? 16  LEU A O   1 
ATOM 118  C CB  . LEU A 1 16  ? 95.886  67.330  93.483  1.00 61.88  ? 16  LEU A CB  1 
ATOM 119  C CG  . LEU A 1 16  ? 94.581  66.531  93.483  1.00 61.88  ? 16  LEU A CG  1 
ATOM 120  C CD1 . LEU A 1 16  ? 94.871  65.040  93.536  1.00 61.88  ? 16  LEU A CD1 1 
ATOM 121  C CD2 . LEU A 1 16  ? 93.683  66.950  94.636  1.00 61.88  ? 16  LEU A CD2 1 
ATOM 122  N N   . LEU A 1 17  ? 97.998  69.737  93.153  1.00 61.74  ? 17  LEU A N   1 
ATOM 123  C CA  . LEU A 1 17  ? 99.302  70.314  93.468  1.00 61.74  ? 17  LEU A CA  1 
ATOM 124  C C   . LEU A 1 17  ? 99.150  71.676  94.139  1.00 61.74  ? 17  LEU A C   1 
ATOM 125  O O   . LEU A 1 17  ? 99.832  71.974  95.130  1.00 61.74  ? 17  LEU A O   1 
ATOM 126  C CB  . LEU A 1 17  ? 100.143 70.409  92.190  1.00 61.74  ? 17  LEU A CB  1 
ATOM 127  C CG  . LEU A 1 17  ? 101.623 70.814  92.216  1.00 61.74  ? 17  LEU A CG  1 
ATOM 128  C CD1 . LEU A 1 17  ? 102.326 70.204  91.017  1.00 61.74  ? 17  LEU A CD1 1 
ATOM 129  C CD2 . LEU A 1 17  ? 101.823 72.326  92.199  1.00 61.74  ? 17  LEU A CD2 1 
ATOM 130  N N   . ILE A 1 18  ? 98.250  72.512  93.614  1.00 57.99  ? 18  ILE A N   1 
ATOM 131  C CA  . ILE A 1 18  ? 97.996  73.818  94.222  1.00 57.99  ? 18  ILE A CA  1 
ATOM 132  C C   . ILE A 1 18  ? 97.439  73.648  95.631  1.00 57.99  ? 18  ILE A C   1 
ATOM 133  O O   . ILE A 1 18  ? 97.846  74.348  96.566  1.00 57.99  ? 18  ILE A O   1 
ATOM 134  C CB  . ILE A 1 18  ? 97.055  74.653  93.333  1.00 57.99  ? 18  ILE A CB  1 
ATOM 135  C CG1 . ILE A 1 18  ? 97.743  75.017  92.018  1.00 57.99  ? 18  ILE A CG1 1 
ATOM 136  C CG2 . ILE A 1 18  ? 96.608  75.918  94.046  1.00 57.99  ? 18  ILE A CG2 1 
ATOM 137  C CD1 . ILE A 1 18  ? 96.820  75.651  91.007  1.00 57.99  ? 18  ILE A CD1 1 
ATOM 138  N N   . LEU A 1 19  ? 96.514  72.699  95.807  1.00 65.31  ? 19  LEU A N   1 
ATOM 139  C CA  . LEU A 1 19  ? 95.939  72.454  97.127  1.00 65.31  ? 19  LEU A CA  1 
ATOM 140  C C   . LEU A 1 19  ? 96.986  71.933  98.106  1.00 65.31  ? 19  LEU A C   1 
ATOM 141  O O   . LEU A 1 19  ? 96.984  72.309  99.284  1.00 65.31  ? 19  LEU A O   1 
ATOM 142  C CB  . LEU A 1 19  ? 94.767  71.476  97.007  1.00 65.31  ? 19  LEU A CB  1 
ATOM 143  C CG  . LEU A 1 19  ? 93.839  71.255  98.205  1.00 65.31  ? 19  LEU A CG  1 
ATOM 144  C CD1 . LEU A 1 19  ? 92.419  71.035  97.718  1.00 65.31  ? 19  LEU A CD1 1 
ATOM 145  C CD2 . LEU A 1 19  ? 94.282  70.067  99.049  1.00 65.31  ? 19  LEU A CD2 1 
ATOM 146  N N   . LEU A 1 20  ? 97.885  71.061  97.641  1.00 69.40  ? 20  LEU A N   1 
ATOM 147  C CA  . LEU A 1 20  ? 98.931  70.531  98.508  1.00 69.40  ? 20  LEU A CA  1 
ATOM 148  C C   . LEU A 1 20  ? 99.903  71.621  98.932  1.00 69.40  ? 20  LEU A C   1 
ATOM 149  O O   . LEU A 1 20  ? 100.306 71.672  100.098 1.00 69.40  ? 20  LEU A O   1 
ATOM 150  C CB  . LEU A 1 20  ? 99.674  69.391  97.811  1.00 69.40  ? 20  LEU A CB  1 
ATOM 151  C CG  . LEU A 1 20  ? 98.980  68.028  97.751  1.00 69.40  ? 20  LEU A CG  1 
ATOM 152  C CD1 . LEU A 1 20  ? 99.969  66.942  97.359  1.00 69.40  ? 20  LEU A CD1 1 
ATOM 153  C CD2 . LEU A 1 20  ? 98.310  67.693  99.073  1.00 69.40  ? 20  LEU A CD2 1 
ATOM 154  N N   . VAL A 1 21  ? 100.281 72.509  98.009  1.00 69.82  ? 21  VAL A N   1 
ATOM 155  C CA  . VAL A 1 21  ? 101.140 73.634  98.379  1.00 69.82  ? 21  VAL A CA  1 
ATOM 156  C C   . VAL A 1 21  ? 100.418 74.551  99.362  1.00 69.82  ? 21  VAL A C   1 
ATOM 157  O O   . VAL A 1 21  ? 101.010 75.033  100.339 1.00 69.82  ? 21  VAL A O   1 
ATOM 158  C CB  . VAL A 1 21  ? 101.603 74.391  97.120  1.00 69.82  ? 21  VAL A CB  1 
ATOM 159  C CG1 . VAL A 1 21  ? 102.323 75.674  97.496  1.00 69.82  ? 21  VAL A CG1 1 
ATOM 160  C CG2 . VAL A 1 21  ? 102.508 73.507  96.276  1.00 69.82  ? 21  VAL A CG2 1 
ATOM 161  N N   . GLY A 1 22  ? 99.123  74.782  99.135  1.00 75.28  ? 22  GLY A N   1 
ATOM 162  C CA  . GLY A 1 22  ? 98.360  75.644  100.023 1.00 75.28  ? 22  GLY A CA  1 
ATOM 163  C C   . GLY A 1 22  ? 98.244  75.095  101.432 1.00 75.28  ? 22  GLY A C   1 
ATOM 164  O O   . GLY A 1 22  ? 98.350  75.838  102.411 1.00 75.28  ? 22  GLY A O   1 
ATOM 165  N N   . ILE A 1 23  ? 98.015  73.786  101.558 1.00 78.99  ? 23  ILE A N   1 
ATOM 166  C CA  . ILE A 1 23  ? 97.899  73.203  102.892 1.00 78.99  ? 23  ILE A CA  1 
ATOM 167  C C   . ILE A 1 23  ? 99.275  73.034  103.526 1.00 78.99  ? 23  ILE A C   1 
ATOM 168  O O   . ILE A 1 23  ? 99.408  73.066  104.753 1.00 78.99  ? 23  ILE A O   1 
ATOM 169  C CB  . ILE A 1 23  ? 97.117  71.875  102.858 1.00 78.99  ? 23  ILE A CB  1 
ATOM 170  C CG1 . ILE A 1 23  ? 97.853  70.811  102.045 1.00 78.99  ? 23  ILE A CG1 1 
ATOM 171  C CG2 . ILE A 1 23  ? 95.708  72.096  102.321 1.00 78.99  ? 23  ILE A CG2 1 
ATOM 172  C CD1 . ILE A 1 23  ? 97.292  69.419  102.222 1.00 78.99  ? 23  ILE A CD1 1 
ATOM 173  N N   . TRP A 1 24  ? 100.322 72.871  102.711 1.00 84.99  ? 24  TRP A N   1 
ATOM 174  C CA  . TRP A 1 24  ? 101.674 72.771  103.253 1.00 84.99  ? 24  TRP A CA  1 
ATOM 175  C C   . TRP A 1 24  ? 102.139 74.107  103.816 1.00 84.99  ? 24  TRP A C   1 
ATOM 176  O O   . TRP A 1 24  ? 102.883 74.148  104.805 1.00 84.99  ? 24  TRP A O   1 
ATOM 177  C CB  . TRP A 1 24  ? 102.631 72.274  102.169 1.00 84.99  ? 24  TRP A CB  1 
ATOM 178  C CG  . TRP A 1 24  ? 104.084 72.393  102.519 1.00 84.99  ? 24  TRP A CG  1 
ATOM 179  C CD1 . TRP A 1 24  ? 104.849 71.469  103.170 1.00 84.99  ? 24  TRP A CD1 1 
ATOM 180  C CD2 . TRP A 1 24  ? 104.953 73.492  102.218 1.00 84.99  ? 24  TRP A CD2 1 
ATOM 181  N NE1 . TRP A 1 24  ? 106.137 71.929  103.302 1.00 84.99  ? 24  TRP A NE1 1 
ATOM 182  C CE2 . TRP A 1 24  ? 106.227 73.169  102.727 1.00 84.99  ? 24  TRP A CE2 1 
ATOM 183  C CE3 . TRP A 1 24  ? 104.776 74.721  101.576 1.00 84.99  ? 24  TRP A CE3 1 
ATOM 184  C CZ2 . TRP A 1 24  ? 107.317 74.028  102.610 1.00 84.99  ? 24  TRP A CZ2 1 
ATOM 185  C CZ3 . TRP A 1 24  ? 105.859 75.573  101.461 1.00 84.99  ? 24  TRP A CZ3 1 
ATOM 186  C CH2 . TRP A 1 24  ? 107.113 75.222  101.975 1.00 84.99  ? 24  TRP A CH2 1 
ATOM 187  N N   . ALA A 1 25  ? 101.715 75.210  103.193 1.00 87.68  ? 25  ALA A N   1 
ATOM 188  C CA  . ALA A 1 25  ? 102.049 76.533  103.713 1.00 87.68  ? 25  ALA A CA  1 
ATOM 189  C C   . ALA A 1 25  ? 101.459 76.742  105.104 1.00 87.68  ? 25  ALA A C   1 
ATOM 190  O O   . ALA A 1 25  ? 102.111 77.309  105.989 1.00 87.68  ? 25  ALA A O   1 
ATOM 191  C CB  . ALA A 1 25  ? 101.559 77.614  102.749 1.00 87.68  ? 25  ALA A CB  1 
ATOM 192  N N   . ALA A 1 26  ? 100.222 76.287  105.315 1.00 91.09  ? 26  ALA A N   1 
ATOM 193  C CA  . ALA A 1 26  ? 99.615  76.385  106.639 1.00 91.09  ? 26  ALA A CA  1 
ATOM 194  C C   . ALA A 1 26  ? 100.183 75.347  107.600 1.00 91.09  ? 26  ALA A C   1 
ATOM 195  O O   . ALA A 1 26  ? 100.214 75.581  108.814 1.00 91.09  ? 26  ALA A O   1 
ATOM 196  C CB  . ALA A 1 26  ? 98.098  76.239  106.534 1.00 91.09  ? 26  ALA A CB  1 
ATOM 197  N N   . TRP A 1 27  ? 100.617 74.195  107.081 1.00 96.40  ? 27  TRP A N   1 
ATOM 198  C CA  . TRP A 1 27  ? 101.246 73.179  107.918 1.00 96.40  ? 27  TRP A CA  1 
ATOM 199  C C   . TRP A 1 27  ? 102.567 73.677  108.487 1.00 96.40  ? 27  TRP A C   1 
ATOM 200  O O   . TRP A 1 27  ? 102.896 73.395  109.645 1.00 96.40  ? 27  TRP A O   1 
ATOM 201  C CB  . TRP A 1 27  ? 101.452 71.899  107.108 1.00 96.40  ? 27  TRP A CB  1 
ATOM 202  C CG  . TRP A 1 27  ? 102.115 70.788  107.863 1.00 96.40  ? 27  TRP A CG  1 
ATOM 203  C CD1 . TRP A 1 27  ? 103.430 70.427  107.805 1.00 96.40  ? 27  TRP A CD1 1 
ATOM 204  C CD2 . TRP A 1 27  ? 101.491 69.881  108.780 1.00 96.40  ? 27  TRP A CD2 1 
ATOM 205  N NE1 . TRP A 1 27  ? 103.665 69.357  108.634 1.00 96.40  ? 27  TRP A NE1 1 
ATOM 206  C CE2 . TRP A 1 27  ? 102.491 69.002  109.244 1.00 96.40  ? 27  TRP A CE2 1 
ATOM 207  C CE3 . TRP A 1 27  ? 100.185 69.729  109.257 1.00 96.40  ? 27  TRP A CE3 1 
ATOM 208  C CZ2 . TRP A 1 27  ? 102.225 67.986  110.161 1.00 96.40  ? 27  TRP A CZ2 1 
ATOM 209  C CZ3 . TRP A 1 27  ? 99.924  68.720  110.167 1.00 96.40  ? 27  TRP A CZ3 1 
ATOM 210  C CH2 . TRP A 1 27  ? 100.939 67.862  110.609 1.00 96.40  ? 27  TRP A CH2 1 
ATOM 211  N N   . ARG A 1 28  ? 103.342 74.409  107.683 1.00 93.93  ? 28  ARG A N   1 
ATOM 212  C CA  . ARG A 1 28  ? 104.555 75.032  108.200 1.00 93.93  ? 28  ARG A CA  1 
ATOM 213  C C   . ARG A 1 28  ? 104.224 76.129  109.205 1.00 93.93  ? 28  ARG A C   1 
ATOM 214  O O   . ARG A 1 28  ? 104.970 76.342  110.169 1.00 93.93  ? 28  ARG A O   1 
ATOM 215  C CB  . ARG A 1 28  ? 105.394 75.590  107.052 1.00 93.93  ? 28  ARG A CB  1 
ATOM 216  C CG  . ARG A 1 28  ? 106.817 75.946  107.449 1.00 93.93  ? 28  ARG A CG  1 
ATOM 217  C CD  . ARG A 1 28  ? 107.763 75.878  106.264 1.00 93.93  ? 28  ARG A CD  1 
ATOM 218  N NE  . ARG A 1 28  ? 109.153 76.043  106.672 1.00 93.93  ? 28  ARG A NE  1 
ATOM 219  C CZ  . ARG A 1 28  ? 109.966 75.044  106.986 1.00 93.93  ? 28  ARG A CZ  1 
ATOM 220  N NH1 . ARG A 1 28  ? 109.561 73.785  106.948 1.00 93.93  ? 28  ARG A NH1 1 
ATOM 221  N NH2 . ARG A 1 28  ? 111.217 75.314  107.348 1.00 93.93  ? 28  ARG A NH2 1 
ATOM 222  N N   . THR A 1 29  ? 103.114 76.832  108.998 1.00 93.82  ? 29  THR A N   1 
ATOM 223  C CA  . THR A 1 29  ? 102.688 77.893  109.904 1.00 93.82  ? 29  THR A CA  1 
ATOM 224  C C   . THR A 1 29  ? 102.262 77.334  111.259 1.00 93.82  ? 29  THR A C   1 
ATOM 225  O O   . THR A 1 29  ? 101.464 76.399  111.335 1.00 93.82  ? 29  THR A O   1 
ATOM 226  C CB  . THR A 1 29  ? 101.522 78.704  109.309 1.00 93.82  ? 29  THR A CB  1 
ATOM 227  O OG1 . THR A 1 29  ? 101.946 79.338  108.096 1.00 93.82  ? 29  THR A OG1 1 
ATOM 228  C CG2 . THR A 1 29  ? 101.054 79.765  110.294 1.00 93.82  ? 29  THR A CG2 1 
ATOM 229  N N   . ARG A 1 47  ? 115.046 87.503  103.796 1.00 110.24 ? 47  ARG A N   1 
ATOM 230  C CA  . ARG A 1 47  ? 115.674 88.808  103.624 1.00 110.24 ? 47  ARG A CA  1 
ATOM 231  C C   . ARG A 1 47  ? 114.627 89.897  103.400 1.00 110.24 ? 47  ARG A C   1 
ATOM 232  O O   . ARG A 1 47  ? 114.836 90.818  102.606 1.00 110.24 ? 47  ARG A O   1 
ATOM 233  C CB  . ARG A 1 47  ? 116.673 88.769  102.463 1.00 110.24 ? 47  ARG A CB  1 
ATOM 234  C CG  . ARG A 1 47  ? 116.101 88.254  101.150 1.00 110.24 ? 47  ARG A CG  1 
ATOM 235  C CD  . ARG A 1 47  ? 116.857 88.826  99.963  1.00 110.24 ? 47  ARG A CD  1 
ATOM 236  N NE  . ARG A 1 47  ? 116.642 90.261  99.819  1.00 110.24 ? 47  ARG A NE  1 
ATOM 237  C CZ  . ARG A 1 47  ? 117.188 91.008  98.869  1.00 110.24 ? 47  ARG A CZ  1 
ATOM 238  N NH1 . ARG A 1 47  ? 117.991 90.487  97.955  1.00 110.24 ? 47  ARG A NH1 1 
ATOM 239  N NH2 . ARG A 1 47  ? 116.921 92.310  98.834  1.00 110.24 ? 47  ARG A NH2 1 
ATOM 240  N N   . ASP A 1 48  ? 113.511 89.775  104.123 1.00 103.52 ? 48  ASP A N   1 
ATOM 241  C CA  . ASP A 1 48  ? 112.385 90.711  104.067 1.00 103.52 ? 48  ASP A CA  1 
ATOM 242  C C   . ASP A 1 48  ? 111.825 90.825  102.647 1.00 103.52 ? 48  ASP A C   1 
ATOM 243  O O   . ASP A 1 48  ? 111.829 91.889  102.025 1.00 103.52 ? 48  ASP A O   1 
ATOM 244  C CB  . ASP A 1 48  ? 112.779 92.085  104.623 1.00 103.52 ? 48  ASP A CB  1 
ATOM 245  C CG  . ASP A 1 48  ? 112.985 92.069  106.124 1.00 103.52 ? 48  ASP A CG  1 
ATOM 246  O OD1 . ASP A 1 48  ? 112.331 91.251  106.805 1.00 103.52 ? 48  ASP A OD1 1 
ATOM 247  O OD2 . ASP A 1 48  ? 113.800 92.873  106.624 1.00 103.52 ? 48  ASP A OD2 1 
ATOM 248  N N   . ILE A 1 49  ? 111.336 89.692  102.142 1.00 88.40  ? 49  ILE A N   1 
ATOM 249  C CA  . ILE A 1 49  ? 110.653 89.643  100.855 1.00 88.40  ? 49  ILE A CA  1 
ATOM 250  C C   . ILE A 1 49  ? 109.137 89.698  101.017 1.00 88.40  ? 49  ILE A C   1 
ATOM 251  O O   . ILE A 1 49  ? 108.403 89.380  100.076 1.00 88.40  ? 49  ILE A O   1 
ATOM 252  C CB  . ILE A 1 49  ? 111.076 88.403  100.050 1.00 88.40  ? 49  ILE A CB  1 
ATOM 253  C CG1 . ILE A 1 49  ? 110.562 87.123  100.714 1.00 88.40  ? 49  ILE A CG1 1 
ATOM 254  C CG2 . ILE A 1 49  ? 112.587 88.365  99.890  1.00 88.40  ? 49  ILE A CG2 1 
ATOM 255  C CD1 . ILE A 1 49  ? 110.465 85.944  99.772  1.00 88.40  ? 49  ILE A CD1 1 
ATOM 256  N N   . GLY A 1 50  ? 108.651 90.104  102.192 1.00 76.92  ? 50  GLY A N   1 
ATOM 257  C CA  . GLY A 1 50  ? 107.215 90.177  102.407 1.00 76.92  ? 50  GLY A CA  1 
ATOM 258  C C   . GLY A 1 50  ? 106.545 91.242  101.562 1.00 76.92  ? 50  GLY A C   1 
ATOM 259  O O   . GLY A 1 50  ? 105.347 91.164  101.285 1.00 76.92  ? 50  GLY A O   1 
ATOM 260  N N   . LEU A 1 51  ? 107.307 92.258  101.150 1.00 72.69  ? 51  LEU A N   1 
ATOM 261  C CA  . LEU A 1 51  ? 106.778 93.276  100.248 1.00 72.69  ? 51  LEU A CA  1 
ATOM 262  C C   . LEU A 1 51  ? 106.401 92.675  98.899  1.00 72.69  ? 51  LEU A C   1 
ATOM 263  O O   . LEU A 1 51  ? 105.323 92.953  98.358  1.00 72.69  ? 51  LEU A O   1 
ATOM 264  C CB  . LEU A 1 51  ? 107.808 94.392  100.075 1.00 72.69  ? 51  LEU A CB  1 
ATOM 265  C CG  . LEU A 1 51  ? 107.304 95.710  99.495  1.00 72.69  ? 51  LEU A CG  1 
ATOM 266  C CD1 . LEU A 1 51  ? 106.177 96.255  100.344 1.00 72.69  ? 51  LEU A CD1 1 
ATOM 267  C CD2 . LEU A 1 51  ? 108.441 96.713  99.398  1.00 72.69  ? 51  LEU A CD2 1 
ATOM 268  N N   . LEU A 1 52  ? 107.281 91.837  98.346  1.00 70.83  ? 52  LEU A N   1 
ATOM 269  C CA  . LEU A 1 52  ? 107.008 91.195  97.065  1.00 70.83  ? 52  LEU A CA  1 
ATOM 270  C C   . LEU A 1 52  ? 105.814 90.254  97.165  1.00 70.83  ? 52  LEU A C   1 
ATOM 271  O O   . LEU A 1 52  ? 104.966 90.207  96.266  1.00 70.83  ? 52  LEU A O   1 
ATOM 272  C CB  . LEU A 1 52  ? 108.252 90.444  96.590  1.00 70.83  ? 52  LEU A CB  1 
ATOM 273  C CG  . LEU A 1 52  ? 108.198 89.806  95.201  1.00 70.83  ? 52  LEU A CG  1 
ATOM 274  C CD1 . LEU A 1 52  ? 108.081 90.874  94.123  1.00 70.83  ? 52  LEU A CD1 1 
ATOM 275  C CD2 . LEU A 1 52  ? 109.416 88.927  94.967  1.00 70.83  ? 52  LEU A CD2 1 
ATOM 276  N N   . VAL A 1 53  ? 105.729 89.499  98.264  1.00 66.06  ? 53  VAL A N   1 
ATOM 277  C CA  . VAL A 1 53  ? 104.618 88.572  98.457  1.00 66.06  ? 53  VAL A CA  1 
ATOM 278  C C   . VAL A 1 53  ? 103.306 89.325  98.636  1.00 66.06  ? 53  VAL A C   1 
ATOM 279  O O   . VAL A 1 53  ? 102.263 88.901  98.122  1.00 66.06  ? 53  VAL A O   1 
ATOM 280  C CB  . VAL A 1 53  ? 104.915 87.640  99.650  1.00 66.06  ? 53  VAL A CB  1 
ATOM 281  C CG1 . VAL A 1 53  ? 103.754 86.698  99.901  1.00 66.06  ? 53  VAL A CG1 1 
ATOM 282  C CG2 . VAL A 1 53  ? 106.194 86.855  99.398  1.00 66.06  ? 53  VAL A CG2 1 
ATOM 283  N N   . GLY A 1 54  ? 103.331 90.452  99.350  1.00 60.55  ? 54  GLY A N   1 
ATOM 284  C CA  . GLY A 1 54  ? 102.131 91.263  99.478  1.00 60.55  ? 54  GLY A CA  1 
ATOM 285  C C   . GLY A 1 54  ? 101.688 91.865  98.158  1.00 60.55  ? 54  GLY A C   1 
ATOM 286  O O   . GLY A 1 54  ? 100.489 91.943  97.872  1.00 60.55  ? 54  GLY A O   1 
ATOM 287  N N   . GLY A 1 55  ? 102.647 92.307  97.339  1.00 54.60  ? 55  GLY A N   1 
ATOM 288  C CA  . GLY A 1 55  ? 102.309 92.776  96.007  1.00 54.60  ? 55  GLY A CA  1 
ATOM 289  C C   . GLY A 1 55  ? 101.713 91.689  95.136  1.00 54.60  ? 55  GLY A C   1 
ATOM 290  O O   . GLY A 1 55  ? 100.753 91.934  94.401  1.00 54.60  ? 55  GLY A O   1 
ATOM 291  N N   . PHE A 1 56  ? 102.258 90.474  95.222  1.00 57.80  ? 56  PHE A N   1 
ATOM 292  C CA  . PHE A 1 56  ? 101.686 89.335  94.508  1.00 57.80  ? 56  PHE A CA  1 
ATOM 293  C C   . PHE A 1 56  ? 100.262 89.052  94.976  1.00 57.80  ? 56  PHE A C   1 
ATOM 294  O O   . PHE A 1 56  ? 99.374  88.767  94.163  1.00 57.80  ? 56  PHE A O   1 
ATOM 295  C CB  . PHE A 1 56  ? 102.568 88.102  94.706  1.00 57.80  ? 56  PHE A CB  1 
ATOM 296  C CG  . PHE A 1 56  ? 103.563 87.874  93.601  1.00 57.80  ? 56  PHE A CG  1 
ATOM 297  C CD1 . PHE A 1 56  ? 104.740 88.603  93.547  1.00 57.80  ? 56  PHE A CD1 1 
ATOM 298  C CD2 . PHE A 1 56  ? 103.330 86.913  92.630  1.00 57.80  ? 56  PHE A CD2 1 
ATOM 299  C CE1 . PHE A 1 56  ? 105.660 88.388  92.536  1.00 57.80  ? 56  PHE A CE1 1 
ATOM 300  C CE2 . PHE A 1 56  ? 104.245 86.693  91.617  1.00 57.80  ? 56  PHE A CE2 1 
ATOM 301  C CZ  . PHE A 1 56  ? 105.412 87.431  91.570  1.00 57.80  ? 56  PHE A CZ  1 
ATOM 302  N N   . THR A 1 57  ? 100.033 89.119  96.289  1.00 57.75  ? 57  THR A N   1 
ATOM 303  C CA  . THR A 1 57  ? 98.707  88.853  96.839  1.00 57.75  ? 57  THR A CA  1 
ATOM 304  C C   . THR A 1 57  ? 97.695  89.899  96.384  1.00 57.75  ? 57  THR A C   1 
ATOM 305  O O   . THR A 1 57  ? 96.568  89.558  96.007  1.00 57.75  ? 57  THR A O   1 
ATOM 306  C CB  . THR A 1 57  ? 98.784  88.801  98.365  1.00 57.75  ? 57  THR A CB  1 
ATOM 307  O OG1 . THR A 1 57  ? 99.593  87.687  98.760  1.00 57.75  ? 57  THR A OG1 1 
ATOM 308  C CG2 . THR A 1 57  ? 97.400  88.651  98.980  1.00 57.75  ? 57  THR A CG2 1 
ATOM 309  N N   . MET A 1 58  ? 98.084  91.177  96.400  1.00 53.97  ? 58  MET A N   1 
ATOM 310  C CA  . MET A 1 58  ? 97.188  92.231  95.930  1.00 53.97  ? 58  MET A CA  1 
ATOM 311  C C   . MET A 1 58  ? 96.921  92.098  94.434  1.00 53.97  ? 58  MET A C   1 
ATOM 312  O O   . MET A 1 58  ? 95.804  92.347  93.967  1.00 53.97  ? 58  MET A O   1 
ATOM 313  C CB  . MET A 1 58  ? 97.772  93.609  96.245  1.00 53.97  ? 58  MET A CB  1 
ATOM 314  C CG  . MET A 1 58  ? 96.840  94.765  95.893  1.00 53.97  ? 58  MET A CG  1 
ATOM 315  S SD  . MET A 1 58  ? 95.291  94.897  96.778  1.00 53.97  ? 58  MET A SD  1 
ATOM 316  C CE  . MET A 1 58  ? 95.934  95.454  98.345  1.00 53.97  ? 58  MET A CE  1 
ATOM 317  N N   . THR A 1 59  ? 97.943  91.711  93.663  1.00 47.13  ? 59  THR A N   1 
ATOM 318  C CA  . THR A 1 59  ? 97.771  91.522  92.226  1.00 47.13  ? 59  THR A CA  1 
ATOM 319  C C   . THR A 1 59  ? 96.814  90.375  91.924  1.00 47.13  ? 59  THR A C   1 
ATOM 320  O O   . THR A 1 59  ? 95.974  90.478  91.023  1.00 47.13  ? 59  THR A O   1 
ATOM 321  C CB  . THR A 1 59  ? 99.130  91.269  91.571  1.00 47.13  ? 59  THR A CB  1 
ATOM 322  O OG1 . THR A 1 59  ? 99.990  92.389  91.806  1.00 47.13  ? 59  THR A OG1 1 
ATOM 323  C CG2 . THR A 1 59  ? 98.988  91.059  90.074  1.00 47.13  ? 59  THR A CG2 1 
ATOM 324  N N   . ALA A 1 60  ? 96.917  89.278  92.681  1.00 45.32  ? 60  ALA A N   1 
ATOM 325  C CA  . ALA A 1 60  ? 96.134  88.080  92.395  1.00 45.32  ? 60  ALA A CA  1 
ATOM 326  C C   . ALA A 1 60  ? 94.639  88.273  92.618  1.00 45.32  ? 60  ALA A C   1 
ATOM 327  O O   . ALA A 1 60  ? 93.852  87.423  92.187  1.00 45.32  ? 60  ALA A O   1 
ATOM 328  C CB  . ALA A 1 60  ? 96.635  86.914  93.247  1.00 45.32  ? 60  ALA A CB  1 
ATOM 329  N N   . THR A 1 61  ? 94.227  89.350  93.288  1.00 47.26  ? 61  THR A N   1 
ATOM 330  C CA  . THR A 1 61  ? 92.800  89.619  93.440  1.00 47.26  ? 61  THR A CA  1 
ATOM 331  C C   . THR A 1 61  ? 92.158  89.969  92.103  1.00 47.26  ? 61  THR A C   1 
ATOM 332  O O   . THR A 1 61  ? 91.132  89.391  91.727  1.00 47.26  ? 61  THR A O   1 
ATOM 333  C CB  . THR A 1 61  ? 92.574  90.742  94.453  1.00 47.26  ? 61  THR A CB  1 
ATOM 334  O OG1 . THR A 1 61  ? 92.906  92.003  93.858  1.00 47.26  ? 61  THR A OG1 1 
ATOM 335  C CG2 . THR A 1 61  ? 93.423  90.522  95.694  1.00 47.26  ? 61  THR A CG2 1 
ATOM 336  N N   . TRP A 1 62  ? 92.751  90.909  91.363  1.00 45.00  ? 62  TRP A N   1 
ATOM 337  C CA  . TRP A 1 62  ? 92.153  91.325  90.099  1.00 45.00  ? 62  TRP A CA  1 
ATOM 338  C C   . TRP A 1 62  ? 92.525  90.372  88.970  1.00 45.00  ? 62  TRP A C   1 
ATOM 339  O O   . TRP A 1 62  ? 91.682  90.029  88.133  1.00 45.00  ? 62  TRP A O   1 
ATOM 340  C CB  . TRP A 1 62  ? 92.567  92.757  89.754  1.00 45.00  ? 62  TRP A CB  1 
ATOM 341  C CG  . TRP A 1 62  ? 91.713  93.827  90.396  1.00 45.00  ? 62  TRP A CG  1 
ATOM 342  C CD1 . TRP A 1 62  ? 92.159  94.909  91.098  1.00 45.00  ? 62  TRP A CD1 1 
ATOM 343  C CD2 . TRP A 1 62  ? 90.276  93.919  90.393  1.00 45.00  ? 62  TRP A CD2 1 
ATOM 344  N NE1 . TRP A 1 62  ? 91.098  95.664  91.533  1.00 45.00  ? 62  TRP A NE1 1 
ATOM 345  C CE2 . TRP A 1 62  ? 89.932  95.079  91.115  1.00 45.00  ? 62  TRP A CE2 1 
ATOM 346  C CE3 . TRP A 1 62  ? 89.250  93.135  89.850  1.00 45.00  ? 62  TRP A CE3 1 
ATOM 347  C CZ2 . TRP A 1 62  ? 88.611  95.470  91.312  1.00 45.00  ? 62  TRP A CZ2 1 
ATOM 348  C CZ3 . TRP A 1 62  ? 87.941  93.526  90.047  1.00 45.00  ? 62  TRP A CZ3 1 
ATOM 349  C CH2 . TRP A 1 62  ? 87.632  94.683  90.770  1.00 45.00  ? 62  TRP A CH2 1 
ATOM 350  N N   . VAL A 1 63  ? 93.779  89.936  88.926  1.00 39.05  ? 63  VAL A N   1 
ATOM 351  C CA  . VAL A 1 63  ? 94.236  89.061  87.853  1.00 39.05  ? 63  VAL A CA  1 
ATOM 352  C C   . VAL A 1 63  ? 93.718  87.651  88.107  1.00 39.05  ? 63  VAL A C   1 
ATOM 353  O O   . VAL A 1 63  ? 94.101  87.001  89.084  1.00 39.05  ? 63  VAL A O   1 
ATOM 354  C CB  . VAL A 1 63  ? 95.765  89.077  87.731  1.00 39.05  ? 63  VAL A CB  1 
ATOM 355  C CG1 . VAL A 1 63  ? 96.199  88.256  86.531  1.00 39.05  ? 63  VAL A CG1 1 
ATOM 356  C CG2 . VAL A 1 63  ? 96.261  90.502  87.597  1.00 39.05  ? 63  VAL A CG2 1 
ATOM 357  N N   . GLY A 1 64  ? 92.854  87.185  87.230  1.00 37.14  ? 64  GLY A N   1 
ATOM 358  C CA  . GLY A 1 64  ? 92.312  85.844  87.313  1.00 37.14  ? 64  GLY A CA  1 
ATOM 359  C C   . GLY A 1 64  ? 91.896  85.443  85.927  1.00 37.14  ? 64  GLY A C   1 
ATOM 360  O O   . GLY A 1 64  ? 92.439  85.941  84.938  1.00 37.14  ? 64  GLY A O   1 
ATOM 361  N N   . GLY A 1 65  ? 90.922  84.537  85.846  1.00 34.12  ? 65  GLY A N   1 
ATOM 362  C CA  . GLY A 1 65  ? 90.410  84.139  84.544  1.00 34.12  ? 65  GLY A CA  1 
ATOM 363  C C   . GLY A 1 65  ? 89.705  85.274  83.831  1.00 34.12  ? 65  GLY A C   1 
ATOM 364  O O   . GLY A 1 65  ? 89.879  85.472  82.624  1.00 34.12  ? 65  GLY A O   1 
ATOM 365  N N   . GLY A 1 66  ? 88.908  86.042  84.576  1.00 33.65  ? 66  GLY A N   1 
ATOM 366  C CA  . GLY A 1 66  ? 88.197  87.161  83.983  1.00 33.65  ? 66  GLY A CA  1 
ATOM 367  C C   . GLY A 1 66  ? 89.126  88.221  83.422  1.00 33.65  ? 66  GLY A C   1 
ATOM 368  O O   . GLY A 1 66  ? 88.915  88.706  82.312  1.00 33.65  ? 66  GLY A O   1 
ATOM 369  N N   . TYR A 1 67  ? 90.187  88.559  84.162  1.00 32.32  ? 67  TYR A N   1 
ATOM 370  C CA  . TYR A 1 67  ? 91.119  89.596  83.727  1.00 32.32  ? 67  TYR A CA  1 
ATOM 371  C C   . TYR A 1 67  ? 91.795  89.225  82.411  1.00 32.32  ? 67  TYR A C   1 
ATOM 372  O O   . TYR A 1 67  ? 91.718  89.976  81.430  1.00 32.32  ? 67  TYR A O   1 
ATOM 373  C CB  . TYR A 1 67  ? 92.159  89.835  84.829  1.00 32.32  ? 67  TYR A CB  1 
ATOM 374  C CG  . TYR A 1 67  ? 93.163  90.951  84.590  1.00 32.32  ? 67  TYR A CG  1 
ATOM 375  C CD1 . TYR A 1 67  ? 94.288  90.755  83.795  1.00 32.32  ? 67  TYR A CD1 1 
ATOM 376  C CD2 . TYR A 1 67  ? 93.002  92.191  85.191  1.00 32.32  ? 67  TYR A CD2 1 
ATOM 377  C CE1 . TYR A 1 67  ? 95.202  91.766  83.586  1.00 32.32  ? 67  TYR A CE1 1 
ATOM 378  C CE2 . TYR A 1 67  ? 93.913  93.209  84.987  1.00 32.32  ? 67  TYR A CE2 1 
ATOM 379  C CZ  . TYR A 1 67  ? 95.011  92.990  84.185  1.00 32.32  ? 67  TYR A CZ  1 
ATOM 380  O OH  . TYR A 1 67  ? 95.921  93.998  83.981  1.00 32.32  ? 67  TYR A OH  1 
ATOM 381  N N   . ILE A 1 68  ? 92.437  88.057  82.361  1.00 31.04  ? 68  ILE A N   1 
ATOM 382  C CA  . ILE A 1 68  ? 93.207  87.692  81.176  1.00 31.04  ? 68  ILE A CA  1 
ATOM 383  C C   . ILE A 1 68  ? 92.289  87.357  80.005  1.00 31.04  ? 68  ILE A C   1 
ATOM 384  O O   . ILE A 1 68  ? 92.571  87.735  78.861  1.00 31.04  ? 68  ILE A O   1 
ATOM 385  C CB  . ILE A 1 68  ? 94.196  86.551  81.498  1.00 31.04  ? 68  ILE A CB  1 
ATOM 386  C CG1 . ILE A 1 68  ? 93.480  85.302  82.014  1.00 31.04  ? 68  ILE A CG1 1 
ATOM 387  C CG2 . ILE A 1 68  ? 95.233  87.017  82.506  1.00 31.04  ? 68  ILE A CG2 1 
ATOM 388  C CD1 . ILE A 1 68  ? 94.238  84.021  81.783  1.00 31.04  ? 68  ILE A CD1 1 
ATOM 389  N N   . ASN A 1 69  ? 91.166  86.675  80.263  1.00 32.68  ? 69  ASN A N   1 
ATOM 390  C CA  . ASN A 1 69  ? 90.231  86.370  79.187  1.00 32.68  ? 69  ASN A CA  1 
ATOM 391  C C   . ASN A 1 69  ? 89.579  87.626  78.620  1.00 32.68  ? 69  ASN A C   1 
ATOM 392  O O   . ASN A 1 69  ? 89.444  87.742  77.398  1.00 32.68  ? 69  ASN A O   1 
ATOM 393  C CB  . ASN A 1 69  ? 89.165  85.390  79.677  1.00 32.68  ? 69  ASN A CB  1 
ATOM 394  C CG  . ASN A 1 69  ? 89.621  83.944  79.600  1.00 32.68  ? 69  ASN A CG  1 
ATOM 395  O OD1 . ASN A 1 69  ? 90.700  83.596  80.073  1.00 32.68  ? 69  ASN A OD1 1 
ATOM 396  N ND2 . ASN A 1 69  ? 88.799  83.097  78.997  1.00 32.68  ? 69  ASN A ND2 1 
ATOM 397  N N   . GLY A 1 70  ? 89.197  88.581  79.472  1.00 32.70  ? 70  GLY A N   1 
ATOM 398  C CA  . GLY A 1 70  ? 88.620  89.817  78.977  1.00 32.70  ? 70  GLY A CA  1 
ATOM 399  C C   . GLY A 1 70  ? 89.623  90.675  78.231  1.00 32.70  ? 70  GLY A C   1 
ATOM 400  O O   . GLY A 1 70  ? 89.282  91.308  77.231  1.00 32.70  ? 70  GLY A O   1 
ATOM 401  N N   . THR A 1 71  ? 90.870  90.716  78.710  1.00 29.64  ? 71  THR A N   1 
ATOM 402  C CA  . THR A 1 71  ? 91.905  91.465  78.002  1.00 29.64  ? 71  THR A CA  1 
ATOM 403  C C   . THR A 1 71  ? 92.165  90.868  76.624  1.00 29.64  ? 71  THR A C   1 
ATOM 404  O O   . THR A 1 71  ? 92.246  91.595  75.623  1.00 29.64  ? 71  THR A O   1 
ATOM 405  C CB  . THR A 1 71  ? 93.190  91.494  78.831  1.00 29.64  ? 71  THR A CB  1 
ATOM 406  O OG1 . THR A 1 71  ? 92.918  92.060  80.118  1.00 29.64  ? 71  THR A OG1 1 
ATOM 407  C CG2 . THR A 1 71  ? 94.251  92.329  78.139  1.00 29.64  ? 71  THR A CG2 1 
ATOM 408  N N   . ALA A 1 72  ? 92.271  89.537  76.550  1.00 34.34  ? 72  ALA A N   1 
ATOM 409  C CA  . ALA A 1 72  ? 92.487  88.881  75.265  1.00 34.34  ? 72  ALA A CA  1 
ATOM 410  C C   . ALA A 1 72  ? 91.297  89.080  74.334  1.00 34.34  ? 72  ALA A C   1 
ATOM 411  O O   . ALA A 1 72  ? 91.473  89.283  73.128  1.00 34.34  ? 72  ALA A O   1 
ATOM 412  C CB  . ALA A 1 72  ? 92.767  87.395  75.475  1.00 34.34  ? 72  ALA A CB  1 
ATOM 413  N N   . GLU A 1 73  ? 90.078  89.028  74.877  1.00 33.97  ? 73  GLU A N   1 
ATOM 414  C CA  . GLU A 1 73  ? 88.887  89.273  74.070  1.00 33.97  ? 73  GLU A CA  1 
ATOM 415  C C   . GLU A 1 73  ? 88.865  90.699  73.533  1.00 33.97  ? 73  GLU A C   1 
ATOM 416  O O   . GLU A 1 73  ? 88.598  90.920  72.348  1.00 33.97  ? 73  GLU A O   1 
ATOM 417  C CB  . GLU A 1 73  ? 87.634  88.997  74.900  1.00 33.97  ? 73  GLU A CB  1 
ATOM 418  C CG  . GLU A 1 73  ? 86.334  89.229  74.157  1.00 33.97  ? 73  GLU A CG  1 
ATOM 419  C CD  . GLU A 1 73  ? 85.157  89.407  75.092  1.00 33.97  ? 73  GLU A CD  1 
ATOM 420  O OE1 . GLU A 1 73  ? 85.286  89.058  76.284  1.00 33.97  ? 73  GLU A OE1 1 
ATOM 421  O OE2 . GLU A 1 73  ? 84.101  89.891  74.636  1.00 33.97  ? 73  GLU A OE2 1 
ATOM 422  N N   . ALA A 1 74  ? 89.159  91.678  74.392  1.00 36.44  ? 74  ALA A N   1 
ATOM 423  C CA  . ALA A 1 74  ? 89.108  93.079  73.992  1.00 36.44  ? 74  ALA A CA  1 
ATOM 424  C C   . ALA A 1 74  ? 90.146  93.391  72.922  1.00 36.44  ? 74  ALA A C   1 
ATOM 425  O O   . ALA A 1 74  ? 89.877  94.150  71.985  1.00 36.44  ? 74  ALA A O   1 
ATOM 426  C CB  . ALA A 1 74  ? 89.300  93.975  75.213  1.00 36.44  ? 74  ALA A CB  1 
ATOM 427  N N   . VAL A 1 75  ? 91.346  92.820  73.048  1.00 47.13  ? 75  VAL A N   1 
ATOM 428  C CA  . VAL A 1 75  ? 92.328  92.992  71.980  1.00 47.13  ? 75  VAL A CA  1 
ATOM 429  C C   . VAL A 1 75  ? 91.898  92.239  70.721  1.00 47.13  ? 75  VAL A C   1 
ATOM 430  O O   . VAL A 1 75  ? 92.143  92.700  69.599  1.00 47.13  ? 75  VAL A O   1 
ATOM 431  C CB  . VAL A 1 75  ? 93.728  92.564  72.462  1.00 47.13  ? 75  VAL A CB  1 
ATOM 432  C CG1 . VAL A 1 75  ? 94.767  92.784  71.376  1.00 47.13  ? 75  VAL A CG1 1 
ATOM 433  C CG2 . VAL A 1 75  ? 94.119  93.348  73.698  1.00 47.13  ? 75  VAL A CG2 1 
ATOM 434  N N   . TYR A 1 76  ? 91.224  91.095  70.875  1.00 34.00  ? 76  TYR A N   1 
ATOM 435  C CA  . TYR A 1 76  ? 90.914  90.236  69.735  1.00 34.00  ? 76  TYR A CA  1 
ATOM 436  C C   . TYR A 1 76  ? 89.783  90.785  68.867  1.00 34.00  ? 76  TYR A C   1 
ATOM 437  O O   . TYR A 1 76  ? 89.844  90.677  67.638  1.00 34.00  ? 76  TYR A O   1 
ATOM 438  C CB  . TYR A 1 76  ? 90.571  88.831  70.231  1.00 34.00  ? 76  TYR A CB  1 
ATOM 439  C CG  . TYR A 1 76  ? 90.043  87.902  69.164  1.00 34.00  ? 76  TYR A CG  1 
ATOM 440  C CD1 . TYR A 1 76  ? 90.798  87.609  68.040  1.00 34.00  ? 76  TYR A CD1 1 
ATOM 441  C CD2 . TYR A 1 76  ? 88.794  87.311  69.286  1.00 34.00  ? 76  TYR A CD2 1 
ATOM 442  C CE1 . TYR A 1 76  ? 90.324  86.761  67.064  1.00 34.00  ? 76  TYR A CE1 1 
ATOM 443  C CE2 . TYR A 1 76  ? 88.312  86.460  68.315  1.00 34.00  ? 76  TYR A CE2 1 
ATOM 444  C CZ  . TYR A 1 76  ? 89.082  86.189  67.206  1.00 34.00  ? 76  TYR A CZ  1 
ATOM 445  O OH  . TYR A 1 76  ? 88.611  85.344  66.231  1.00 34.00  ? 76  TYR A OH  1 
ATOM 446  N N   . VAL A 1 77  ? 88.745  91.355  69.476  1.00 40.73  ? 77  VAL A N   1 
ATOM 447  C CA  . VAL A 1 77  ? 87.564  91.805  68.721  1.00 40.73  ? 77  VAL A CA  1 
ATOM 448  C C   . VAL A 1 77  ? 87.945  92.974  67.821  1.00 40.73  ? 77  VAL A C   1 
ATOM 449  O O   . VAL A 1 77  ? 88.612  93.916  68.286  1.00 40.73  ? 77  VAL A O   1 
ATOM 450  C CB  . VAL A 1 77  ? 86.433  92.187  69.680  1.00 40.73  ? 77  VAL A CB  1 
ATOM 451  C CG1 . VAL A 1 77  ? 85.219  92.673  68.914  1.00 40.73  ? 77  VAL A CG1 1 
ATOM 452  C CG2 . VAL A 1 77  ? 86.031  90.989  70.512  1.00 40.73  ? 77  VAL A CG2 1 
ATOM 453  N N   . PRO A 1 78  ? 87.570  92.951  66.536  1.00 43.76  ? 78  PRO A N   1 
ATOM 454  C CA  . PRO A 1 78  ? 87.950  94.052  65.631  1.00 43.76  ? 78  PRO A CA  1 
ATOM 455  C C   . PRO A 1 78  ? 87.393  95.407  66.029  1.00 43.76  ? 78  PRO A C   1 
ATOM 456  O O   . PRO A 1 78  ? 88.013  96.433  65.721  1.00 43.76  ? 78  PRO A O   1 
ATOM 457  C CB  . PRO A 1 78  ? 87.388  93.594  64.277  1.00 43.76  ? 78  PRO A CB  1 
ATOM 458  C CG  . PRO A 1 78  ? 87.281  92.115  64.393  1.00 43.76  ? 78  PRO A CG  1 
ATOM 459  C CD  . PRO A 1 78  ? 86.887  91.865  65.814  1.00 43.76  ? 78  PRO A CD  1 
ATOM 460  N N   . GLY A 1 79  ? 86.234  95.446  66.688  1.00 43.81  ? 79  GLY A N   1 
ATOM 461  C CA  . GLY A 1 79  ? 85.653  96.723  67.067  1.00 43.81  ? 79  GLY A CA  1 
ATOM 462  C C   . GLY A 1 79  ? 86.460  97.457  68.122  1.00 43.81  ? 79  GLY A C   1 
ATOM 463  O O   . GLY A 1 79  ? 86.513  98.689  68.130  1.00 43.81  ? 79  GLY A O   1 
ATOM 464  N N   . TYR A 1 80  ? 87.093  96.715  69.029  1.00 43.92  ? 80  TYR A N   1 
ATOM 465  C CA  . TYR A 1 80  ? 87.778  97.329  70.159  1.00 43.92  ? 80  TYR A CA  1 
ATOM 466  C C   . TYR A 1 80  ? 89.261  97.564  69.898  1.00 43.92  ? 80  TYR A C   1 
ATOM 467  O O   . TYR A 1 80  ? 89.719  98.710  69.895  1.00 43.92  ? 80  TYR A O   1 
ATOM 468  C CB  . TYR A 1 80  ? 87.604  96.456  71.402  1.00 43.92  ? 80  TYR A CB  1 
ATOM 469  C CG  . TYR A 1 80  ? 86.207  96.464  71.970  1.00 43.92  ? 80  TYR A CG  1 
ATOM 470  C CD1 . TYR A 1 80  ? 85.828  97.401  72.919  1.00 43.92  ? 80  TYR A CD1 1 
ATOM 471  C CD2 . TYR A 1 80  ? 85.258  95.549  71.538  1.00 43.92  ? 80  TYR A CD2 1 
ATOM 472  C CE1 . TYR A 1 80  ? 84.549  97.414  73.439  1.00 43.92  ? 80  TYR A CE1 1 
ATOM 473  C CE2 . TYR A 1 80  ? 83.976  95.555  72.047  1.00 43.92  ? 80  TYR A CE2 1 
ATOM 474  C CZ  . TYR A 1 80  ? 83.627  96.489  72.997  1.00 43.92  ? 80  TYR A CZ  1 
ATOM 475  O OH  . TYR A 1 80  ? 82.350  96.499  73.508  1.00 43.92  ? 80  TYR A OH  1 
ATOM 476  N N   . GLY A 1 81  ? 90.017  96.497  69.662  1.00 38.08  ? 81  GLY A N   1 
ATOM 477  C CA  . GLY A 1 81  ? 91.456  96.616  69.561  1.00 38.08  ? 81  GLY A CA  1 
ATOM 478  C C   . GLY A 1 81  ? 92.107  96.843  70.914  1.00 38.08  ? 81  GLY A C   1 
ATOM 479  O O   . GLY A 1 81  ? 91.472  96.773  71.969  1.00 38.08  ? 81  GLY A O   1 
ATOM 480  N N   . LEU A 1 82  ? 93.413  97.125  70.873  1.00 37.30  ? 82  LEU A N   1 
ATOM 481  C CA  . LEU A 1 82  ? 94.146  97.398  72.108  1.00 37.30  ? 82  LEU A CA  1 
ATOM 482  C C   . LEU A 1 82  ? 93.764  98.752  72.694  1.00 37.30  ? 82  LEU A C   1 
ATOM 483  O O   . LEU A 1 82  ? 93.726  98.916  73.920  1.00 37.30  ? 82  LEU A O   1 
ATOM 484  C CB  . LEU A 1 82  ? 95.655  97.327  71.858  1.00 37.30  ? 82  LEU A CB  1 
ATOM 485  C CG  . LEU A 1 82  ? 96.580  97.857  72.962  1.00 37.30  ? 82  LEU A CG  1 
ATOM 486  C CD1 . LEU A 1 82  ? 96.452  97.027  74.230  1.00 37.30  ? 82  LEU A CD1 1 
ATOM 487  C CD2 . LEU A 1 82  ? 98.024  97.906  72.507  1.00 37.30  ? 82  LEU A CD2 1 
ATOM 488  N N   . ALA A 1 83  ? 93.474  99.733  71.833  1.00 36.17  ? 83  ALA A N   1 
ATOM 489  C CA  . ALA A 1 83  ? 93.171  101.083 72.302  1.00 36.17  ? 83  ALA A CA  1 
ATOM 490  C C   . ALA A 1 83  ? 91.913  101.111 73.159  1.00 36.17  ? 83  ALA A C   1 
ATOM 491  O O   . ALA A 1 83  ? 91.849  101.838 74.157  1.00 36.17  ? 83  ALA A O   1 
ATOM 492  C CB  . ALA A 1 83  ? 93.026  102.034 71.115  1.00 36.17  ? 83  ALA A CB  1 
ATOM 493  N N   . TRP A 1 84  ? 90.904  100.328 72.789  1.00 37.82  ? 84  TRP A N   1 
ATOM 494  C CA  . TRP A 1 84  ? 89.675  100.266 73.565  1.00 37.82  ? 84  TRP A CA  1 
ATOM 495  C C   . TRP A 1 84  ? 89.730  99.233  74.681  1.00 37.82  ? 84  TRP A C   1 
ATOM 496  O O   . TRP A 1 84  ? 88.797  99.165  75.488  1.00 37.82  ? 84  TRP A O   1 
ATOM 497  C CB  . TRP A 1 84  ? 88.492  99.969  72.643  1.00 37.82  ? 84  TRP A CB  1 
ATOM 498  C CG  . TRP A 1 84  ? 87.985  101.186 71.946  1.00 37.82  ? 84  TRP A CG  1 
ATOM 499  C CD1 . TRP A 1 84  ? 88.287  101.586 70.679  1.00 37.82  ? 84  TRP A CD1 1 
ATOM 500  C CD2 . TRP A 1 84  ? 87.095  102.171 72.477  1.00 37.82  ? 84  TRP A CD2 1 
ATOM 501  N NE1 . TRP A 1 84  ? 87.636  102.757 70.384  1.00 37.82  ? 84  TRP A NE1 1 
ATOM 502  C CE2 . TRP A 1 84  ? 86.898  103.137 71.473  1.00 37.82  ? 84  TRP A CE2 1 
ATOM 503  C CE3 . TRP A 1 84  ? 86.443  102.328 73.703  1.00 37.82  ? 84  TRP A CE3 1 
ATOM 504  C CZ2 . TRP A 1 84  ? 86.076  104.244 71.656  1.00 37.82  ? 84  TRP A CZ2 1 
ATOM 505  C CZ3 . TRP A 1 84  ? 85.629  103.427 73.882  1.00 37.82  ? 84  TRP A CZ3 1 
ATOM 506  C CH2 . TRP A 1 84  ? 85.450  104.369 72.864  1.00 37.82  ? 84  TRP A CH2 1 
ATOM 507  N N   . ALA A 1 85  ? 90.797  98.437  74.748  1.00 34.77  ? 85  ALA A N   1 
ATOM 508  C CA  . ALA A 1 85  ? 91.000  97.501  75.846  1.00 34.77  ? 85  ALA A CA  1 
ATOM 509  C C   . ALA A 1 85  ? 91.486  98.242  77.083  1.00 34.77  ? 85  ALA A C   1 
ATOM 510  O O   . ALA A 1 85  ? 92.626  98.057  77.518  1.00 34.77  ? 85  ALA A O   1 
ATOM 511  C CB  . ALA A 1 85  ? 92.004  96.417  75.452  1.00 34.77  ? 85  ALA A CB  1 
ATOM 512  N N   . GLN A 1 86  ? 90.627  99.081  77.657  1.00 35.56  ? 86  GLN A N   1 
ATOM 513  C CA  . GLN A 1 86  ? 91.030  99.971  78.734  1.00 35.56  ? 86  GLN A CA  1 
ATOM 514  C C   . GLN A 1 86  ? 90.945  99.329  80.108  1.00 35.56  ? 86  GLN A C   1 
ATOM 515  O O   . GLN A 1 86  ? 91.405  99.931  81.082  1.00 35.56  ? 86  GLN A O   1 
ATOM 516  C CB  . GLN A 1 86  ? 90.166  101.235 78.716  1.00 35.56  ? 86  GLN A CB  1 
ATOM 517  C CG  . GLN A 1 86  ? 90.252  102.025 77.424  1.00 35.56  ? 86  GLN A CG  1 
ATOM 518  C CD  . GLN A 1 86  ? 88.944  102.702 77.069  1.00 35.56  ? 86  GLN A CD  1 
ATOM 519  O OE1 . GLN A 1 86  ? 87.943  102.040 76.802  1.00 35.56  ? 86  GLN A OE1 1 
ATOM 520  N NE2 . GLN A 1 86  ? 88.946  104.027 77.065  1.00 35.56  ? 86  GLN A NE2 1 
ATOM 521  N N   . ALA A 1 87  ? 90.362  98.136  80.209  1.00 35.36  ? 87  ALA A N   1 
ATOM 522  C CA  . ALA A 1 87  ? 90.200  97.495  81.513  1.00 35.36  ? 87  ALA A CA  1 
ATOM 523  C C   . ALA A 1 87  ? 91.523  97.146  82.194  1.00 35.36  ? 87  ALA A C   1 
ATOM 524  O O   . ALA A 1 87  ? 91.650  97.427  83.397  1.00 35.36  ? 87  ALA A O   1 
ATOM 525  C CB  . ALA A 1 87  ? 89.279  96.277  81.377  1.00 35.36  ? 87  ALA A CB  1 
ATOM 526  N N   . PRO A 1 88  ? 92.533  96.552  81.531  1.00 34.01  ? 88  PRO A N   1 
ATOM 527  C CA  . PRO A 1 88  ? 93.805  96.336  82.249  1.00 34.01  ? 88  PRO A CA  1 
ATOM 528  C C   . PRO A 1 88  ? 94.515  97.623  82.640  1.00 34.01  ? 88  PRO A C   1 
ATOM 529  O O   . PRO A 1 88  ? 94.924  97.774  83.800  1.00 34.01  ? 88  PRO A O   1 
ATOM 530  C CB  . PRO A 1 88  ? 94.641  95.516  81.255  1.00 34.01  ? 88  PRO A CB  1 
ATOM 531  C CG  . PRO A 1 88  ? 93.985  95.676  79.952  1.00 34.01  ? 88  PRO A CG  1 
ATOM 532  C CD  . PRO A 1 88  ? 92.543  95.863  80.228  1.00 34.01  ? 88  PRO A CD  1 
ATOM 533  N N   . ILE A 1 89  ? 94.668  98.557  81.701  1.00 36.56  ? 89  ILE A N   1 
ATOM 534  C CA  . ILE A 1 89  ? 95.348  99.816  81.987  1.00 36.56  ? 89  ILE A CA  1 
ATOM 535  C C   . ILE A 1 89  ? 94.558  100.637 82.998  1.00 36.56  ? 89  ILE A C   1 
ATOM 536  O O   . ILE A 1 89  ? 95.124  101.208 83.938  1.00 36.56  ? 89  ILE A O   1 
ATOM 537  C CB  . ILE A 1 89  ? 95.576  100.599 80.681  1.00 36.56  ? 89  ILE A CB  1 
ATOM 538  C CG1 . ILE A 1 89  ? 96.412  99.774  79.702  1.00 36.56  ? 89  ILE A CG1 1 
ATOM 539  C CG2 . ILE A 1 89  ? 96.261  101.926 80.966  1.00 36.56  ? 89  ILE A CG2 1 
ATOM 540  C CD1 . ILE A 1 89  ? 97.784  99.423  80.214  1.00 36.56  ? 89  ILE A CD1 1 
ATOM 541  N N   . GLY A 1 90  ? 93.237  100.701 82.818  1.00 35.76  ? 90  GLY A N   1 
ATOM 542  C CA  . GLY A 1 90  ? 92.403  101.435 83.754  1.00 35.76  ? 90  GLY A CA  1 
ATOM 543  C C   . GLY A 1 90  ? 92.403  100.832 85.142  1.00 35.76  ? 90  GLY A C   1 
ATOM 544  O O   . GLY A 1 90  ? 92.392  101.550 86.139  1.00 35.76  ? 90  GLY A O   1 
ATOM 545  N N   . TYR A 1 91  ? 92.441  99.504  85.229  1.00 40.04  ? 91  TYR A N   1 
ATOM 546  C CA  . TYR A 1 91  ? 92.464  98.850  86.529  1.00 40.04  ? 91  TYR A CA  1 
ATOM 547  C C   . TYR A 1 91  ? 93.832  98.910  87.200  1.00 40.04  ? 91  TYR A C   1 
ATOM 548  O O   . TYR A 1 91  ? 93.904  98.800  88.428  1.00 40.04  ? 91  TYR A O   1 
ATOM 549  C CB  . TYR A 1 91  ? 91.991  97.402  86.391  1.00 40.04  ? 91  TYR A CB  1 
ATOM 550  C CG  . TYR A 1 91  ? 90.508  97.245  86.649  1.00 40.04  ? 91  TYR A CG  1 
ATOM 551  C CD1 . TYR A 1 91  ? 90.042  96.811  87.879  1.00 40.04  ? 91  TYR A CD1 1 
ATOM 552  C CD2 . TYR A 1 91  ? 89.574  97.562  85.672  1.00 40.04  ? 91  TYR A CD2 1 
ATOM 553  C CE1 . TYR A 1 91  ? 88.689  96.676  88.120  1.00 40.04  ? 91  TYR A CE1 1 
ATOM 554  C CE2 . TYR A 1 91  ? 88.221  97.433  85.905  1.00 40.04  ? 91  TYR A CE2 1 
ATOM 555  C CZ  . TYR A 1 91  ? 87.784  96.989  87.132  1.00 40.04  ? 91  TYR A CZ  1 
ATOM 556  O OH  . TYR A 1 91  ? 86.437  96.855  87.375  1.00 40.04  ? 91  TYR A OH  1 
ATOM 557  N N   . SER A 1 92  ? 94.912  99.080  86.435  1.00 38.52  ? 92  SER A N   1 
ATOM 558  C CA  . SER A 1 92  ? 96.205  99.372  87.050  1.00 38.52  ? 92  SER A CA  1 
ATOM 559  C C   . SER A 1 92  ? 96.262  100.815 87.544  1.00 38.52  ? 92  SER A C   1 
ATOM 560  O O   . SER A 1 92  ? 96.774  101.097 88.639  1.00 38.52  ? 92  SER A O   1 
ATOM 561  C CB  . SER A 1 92  ? 97.332  99.096  86.057  1.00 38.52  ? 92  SER A CB  1 
ATOM 562  O OG  . SER A 1 92  ? 97.310  97.748  85.628  1.00 38.52  ? 92  SER A OG  1 
ATOM 563  N N   . LEU A 1 93  ? 95.739  101.747 86.744  1.00 37.68  ? 93  LEU A N   1 
ATOM 564  C CA  . LEU A 1 93  ? 95.682  103.139 87.175  1.00 37.68  ? 93  LEU A CA  1 
ATOM 565  C C   . LEU A 1 93  ? 94.737  103.320 88.355  1.00 37.68  ? 93  LEU A C   1 
ATOM 566  O O   . LEU A 1 93  ? 94.918  104.246 89.148  1.00 37.68  ? 93  LEU A O   1 
ATOM 567  C CB  . LEU A 1 93  ? 95.264  104.035 86.012  1.00 37.68  ? 93  LEU A CB  1 
ATOM 568  C CG  . LEU A 1 93  ? 96.411  104.568 85.154  1.00 37.68  ? 93  LEU A CG  1 
ATOM 569  C CD1 . LEU A 1 93  ? 95.899  105.035 83.804  1.00 37.68  ? 93  LEU A CD1 1 
ATOM 570  C CD2 . LEU A 1 93  ? 97.139  105.689 85.873  1.00 37.68  ? 93  LEU A CD2 1 
ATOM 571  N N   . SER A 1 94  ? 93.734  102.451 88.490  1.00 37.72  ? 94  SER A N   1 
ATOM 572  C CA  . SER A 1 94  ? 92.896  102.466 89.682  1.00 37.72  ? 94  SER A CA  1 
ATOM 573  C C   . SER A 1 94  ? 93.696  102.113 90.924  1.00 37.72  ? 94  SER A C   1 
ATOM 574  O O   . SER A 1 94  ? 93.497  102.725 91.975  1.00 37.72  ? 94  SER A O   1 
ATOM 575  C CB  . SER A 1 94  ? 91.727  101.497 89.527  1.00 37.72  ? 94  SER A CB  1 
ATOM 576  O OG  . SER A 1 94  ? 92.178  100.157 89.488  1.00 37.72  ? 94  SER A OG  1 
ATOM 577  N N   . LEU A 1 95  ? 94.602  101.137 90.823  1.00 37.95  ? 95  LEU A N   1 
ATOM 578  C CA  . LEU A 1 95  ? 95.476  100.812 91.947  1.00 37.95  ? 95  LEU A CA  1 
ATOM 579  C C   . LEU A 1 95  ? 96.421  101.964 92.264  1.00 37.95  ? 95  LEU A C   1 
ATOM 580  O O   . LEU A 1 95  ? 96.654  102.277 93.438  1.00 37.95  ? 95  LEU A O   1 
ATOM 581  C CB  . LEU A 1 95  ? 96.262  99.538  91.645  1.00 37.95  ? 95  LEU A CB  1 
ATOM 582  C CG  . LEU A 1 95  ? 95.450  98.244  91.585  1.00 37.95  ? 95  LEU A CG  1 
ATOM 583  C CD1 . LEU A 1 95  ? 96.125  97.232  90.685  1.00 37.95  ? 95  LEU A CD1 1 
ATOM 584  C CD2 . LEU A 1 95  ? 95.252  97.672  92.974  1.00 37.95  ? 95  LEU A CD2 1 
ATOM 585  N N   . ILE A 1 96  ? 96.967  102.611 91.229  1.00 39.98  ? 96  ILE A N   1 
ATOM 586  C CA  . ILE A 1 96  ? 97.840  103.765 91.453  1.00 39.98  ? 96  ILE A CA  1 
ATOM 587  C C   . ILE A 1 96  ? 97.081  104.896 92.142  1.00 39.98  ? 96  ILE A C   1 
ATOM 588  O O   . ILE A 1 96  ? 97.559  105.472 93.128  1.00 39.98  ? 96  ILE A O   1 
ATOM 589  C CB  . ILE A 1 96  ? 98.467  104.239 90.129  1.00 39.98  ? 96  ILE A CB  1 
ATOM 590  C CG1 . ILE A 1 96  ? 99.442  103.197 89.591  1.00 39.98  ? 96  ILE A CG1 1 
ATOM 591  C CG2 . ILE A 1 96  ? 99.183  105.567 90.317  1.00 39.98  ? 96  ILE A CG2 1 
ATOM 592  C CD1 . ILE A 1 96  ? 99.610  103.234 88.091  1.00 39.98  ? 96  ILE A CD1 1 
ATOM 593  N N   . LEU A 1 97  ? 95.882  105.219 91.649  1.00 43.48  ? 97  LEU A N   1 
ATOM 594  C CA  . LEU A 1 97  ? 95.101  106.310 92.223  1.00 43.48  ? 97  LEU A CA  1 
ATOM 595  C C   . LEU A 1 97  ? 94.615  105.969 93.623  1.00 43.48  ? 97  LEU A C   1 
ATOM 596  O O   . LEU A 1 97  ? 94.529  106.852 94.483  1.00 43.48  ? 97  LEU A O   1 
ATOM 597  C CB  . LEU A 1 97  ? 93.920  106.648 91.315  1.00 43.48  ? 97  LEU A CB  1 
ATOM 598  C CG  . LEU A 1 97  ? 94.264  107.410 90.035  1.00 43.48  ? 97  LEU A CG  1 
ATOM 599  C CD1 . LEU A 1 97  ? 93.055  107.485 89.127  1.00 43.48  ? 97  LEU A CD1 1 
ATOM 600  C CD2 . LEU A 1 97  ? 94.785  108.799 90.358  1.00 43.48  ? 97  LEU A CD2 1 
ATOM 601  N N   . GLY A 1 98  ? 94.288  104.699 93.871  1.00 47.41  ? 98  GLY A N   1 
ATOM 602  C CA  . GLY A 1 98  ? 93.955  104.286 95.220  1.00 47.41  ? 98  GLY A CA  1 
ATOM 603  C C   . GLY A 1 98  ? 95.114  104.474 96.176  1.00 47.41  ? 98  GLY A C   1 
ATOM 604  O O   . GLY A 1 98  ? 94.972  105.152 97.194  1.00 47.41  ? 98  GLY A O   1 
ATOM 605  N N   . GLY A 1 99  ? 96.293  103.965 95.805  1.00 47.27  ? 99  GLY A N   1 
ATOM 606  C CA  . GLY A 1 99  ? 97.460  104.096 96.663  1.00 47.27  ? 99  GLY A CA  1 
ATOM 607  C C   . GLY A 1 99  ? 97.857  105.539 96.901  1.00 47.27  ? 99  GLY A C   1 
ATOM 608  O O   . GLY A 1 99  ? 98.366  105.889 97.968  1.00 47.27  ? 99  GLY A O   1 
ATOM 609  N N   . LEU A 1 100 ? 97.627  106.401 95.912  1.00 46.65  ? 100 LEU A N   1 
ATOM 610  C CA  . LEU A 1 100 ? 97.917  107.817 96.095  1.00 46.65  ? 100 LEU A CA  1 
ATOM 611  C C   . LEU A 1 100 ? 96.895  108.511 96.992  1.00 46.65  ? 100 LEU A C   1 
ATOM 612  O O   . LEU A 1 100 ? 97.268  109.098 98.012  1.00 46.65  ? 100 LEU A O   1 
ATOM 613  C CB  . LEU A 1 100 ? 97.992  108.534 94.746  1.00 46.65  ? 100 LEU A CB  1 
ATOM 614  C CG  . LEU A 1 100 ? 99.196  108.220 93.858  1.00 46.65  ? 100 LEU A CG  1 
ATOM 615  C CD1 . LEU A 1 100 ? 98.979  108.755 92.451  1.00 46.65  ? 100 LEU A CD1 1 
ATOM 616  C CD2 . LEU A 1 100 ? 100.468 108.789 94.462  1.00 46.65  ? 100 LEU A CD2 1 
ATOM 617  N N   . PHE A 1 101 ? 95.608  108.454 96.634  1.00 49.46  ? 101 PHE A N   1 
ATOM 618  C CA  . PHE A 1 101 ? 94.647  109.375 97.235  1.00 49.46  ? 101 PHE A CA  1 
ATOM 619  C C   . PHE A 1 101 ? 93.692  108.699 98.215  1.00 49.46  ? 101 PHE A C   1 
ATOM 620  O O   . PHE A 1 101 ? 93.232  109.343 99.163  1.00 49.46  ? 101 PHE A O   1 
ATOM 621  C CB  . PHE A 1 101 ? 93.850  110.081 96.137  1.00 49.46  ? 101 PHE A CB  1 
ATOM 622  C CG  . PHE A 1 101 ? 94.700  110.851 95.169  1.00 49.46  ? 101 PHE A CG  1 
ATOM 623  C CD1 . PHE A 1 101 ? 95.444  111.939 95.594  1.00 49.46  ? 101 PHE A CD1 1 
ATOM 624  C CD2 . PHE A 1 101 ? 94.754  110.491 93.832  1.00 49.46  ? 101 PHE A CD2 1 
ATOM 625  C CE1 . PHE A 1 101 ? 96.226  112.651 94.706  1.00 49.46  ? 101 PHE A CE1 1 
ATOM 626  C CE2 . PHE A 1 101 ? 95.535  111.201 92.940  1.00 49.46  ? 101 PHE A CE2 1 
ATOM 627  C CZ  . PHE A 1 101 ? 96.271  112.281 93.377  1.00 49.46  ? 101 PHE A CZ  1 
ATOM 628  N N   . PHE A 1 102 ? 93.360  107.422 98.014  1.00 54.03  ? 102 PHE A N   1 
ATOM 629  C CA  . PHE A 1 102 ? 92.245  106.849 98.759  1.00 54.03  ? 102 PHE A CA  1 
ATOM 630  C C   . PHE A 1 102 ? 92.716  106.063 99.975  1.00 54.03  ? 102 PHE A C   1 
ATOM 631  O O   . PHE A 1 102 ? 91.980  105.949 100.961 1.00 54.03  ? 102 PHE A O   1 
ATOM 632  C CB  . PHE A 1 102 ? 91.409  105.959 97.841  1.00 54.03  ? 102 PHE A CB  1 
ATOM 633  C CG  . PHE A 1 102 ? 90.530  106.723 96.896  1.00 54.03  ? 102 PHE A CG  1 
ATOM 634  C CD1 . PHE A 1 102 ? 89.299  107.200 97.309  1.00 54.03  ? 102 PHE A CD1 1 
ATOM 635  C CD2 . PHE A 1 102 ? 90.939  106.975 95.598  1.00 54.03  ? 102 PHE A CD2 1 
ATOM 636  C CE1 . PHE A 1 102 ? 88.489  107.907 96.445  1.00 54.03  ? 102 PHE A CE1 1 
ATOM 637  C CE2 . PHE A 1 102 ? 90.134  107.682 94.729  1.00 54.03  ? 102 PHE A CE2 1 
ATOM 638  C CZ  . PHE A 1 102 ? 88.907  108.148 95.154  1.00 54.03  ? 102 PHE A CZ  1 
ATOM 639  N N   . ALA A 1 103 ? 93.927  105.506 99.916  1.00 61.83  ? 103 ALA A N   1 
ATOM 640  C CA  . ALA A 1 103 ? 94.431  104.690 101.016 1.00 61.83  ? 103 ALA A CA  1 
ATOM 641  C C   . ALA A 1 103 ? 94.619  105.514 102.285 1.00 61.83  ? 103 ALA A C   1 
ATOM 642  O O   . ALA A 1 103 ? 94.304  105.054 103.388 1.00 61.83  ? 103 ALA A O   1 
ATOM 643  C CB  . ALA A 1 103 ? 95.744  104.021 100.610 1.00 61.83  ? 103 ALA A CB  1 
ATOM 644  N N   . LYS A 1 104 ? 95.135  106.741 102.150 1.00 72.13  ? 104 LYS A N   1 
ATOM 645  C CA  . LYS A 1 104 ? 95.492  107.503 103.346 1.00 72.13  ? 104 LYS A CA  1 
ATOM 646  C C   . LYS A 1 104 ? 94.279  108.104 104.055 1.00 72.13  ? 104 LYS A C   1 
ATOM 647  O O   . LYS A 1 104 ? 94.264  108.094 105.298 1.00 72.13  ? 104 LYS A O   1 
ATOM 648  C CB  . LYS A 1 104 ? 96.567  108.543 103.002 1.00 72.13  ? 104 LYS A CB  1 
ATOM 649  C CG  . LYS A 1 104 ? 97.443  108.953 104.171 1.00 72.13  ? 104 LYS A CG  1 
ATOM 650  C CD  . LYS A 1 104 ? 98.693  109.666 103.686 1.00 72.13  ? 104 LYS A CD  1 
ATOM 651  C CE  . LYS A 1 104 ? 99.848  109.481 104.653 1.00 72.13  ? 104 LYS A CE  1 
ATOM 652  N NZ  . LYS A 1 104 ? 101.162 109.628 103.968 1.00 72.13  ? 104 LYS A NZ  1 
ATOM 653  N N   . PRO A 1 105 ? 93.268  108.677 103.372 1.00 71.14  ? 105 PRO A N   1 
ATOM 654  C CA  . PRO A 1 105 ? 92.020  108.981 104.091 1.00 71.14  ? 105 PRO A CA  1 
ATOM 655  C C   . PRO A 1 105 ? 91.375  107.783 104.767 1.00 71.14  ? 105 PRO A C   1 
ATOM 656  O O   . PRO A 1 105 ? 90.874  107.910 105.892 1.00 71.14  ? 105 PRO A O   1 
ATOM 657  C CB  . PRO A 1 105 ? 91.126  109.506 102.967 1.00 71.14  ? 105 PRO A CB  1 
ATOM 658  C CG  . PRO A 1 105 ? 92.061  110.252 102.079 1.00 71.14  ? 105 PRO A CG  1 
ATOM 659  C CD  . PRO A 1 105 ? 93.477  109.752 102.382 1.00 71.14  ? 105 PRO A CD  1 
ATOM 660  N N   . MET A 1 106 ? 91.369  106.622 104.105 1.00 73.27  ? 106 MET A N   1 
ATOM 661  C CA  . MET A 1 106 ? 90.715  105.440 104.662 1.00 73.27  ? 106 MET A CA  1 
ATOM 662  C C   . MET A 1 106 ? 91.409  104.973 105.935 1.00 73.27  ? 106 MET A C   1 
ATOM 663  O O   . MET A 1 106 ? 90.753  104.573 106.904 1.00 73.27  ? 106 MET A O   1 
ATOM 664  C CB  . MET A 1 106 ? 90.684  104.319 103.622 1.00 73.27  ? 106 MET A CB  1 
ATOM 665  C CG  . MET A 1 106 ? 89.598  104.465 102.566 1.00 73.27  ? 106 MET A CG  1 
ATOM 666  S SD  . MET A 1 106 ? 87.952  104.072 103.188 1.00 73.27  ? 106 MET A SD  1 
ATOM 667  C CE  . MET A 1 106 ? 87.190  103.351 101.739 1.00 73.27  ? 106 MET A CE  1 
ATOM 668  N N   . ARG A 1 107 ? 92.741  105.007 105.947 1.00 78.61  ? 107 ARG A N   1 
ATOM 669  C CA  . ARG A 1 107 ? 93.476  104.622 107.146 1.00 78.61  ? 107 ARG A CA  1 
ATOM 670  C C   . ARG A 1 107 ? 93.421  105.713 108.209 1.00 78.61  ? 107 ARG A C   1 
ATOM 671  O O   . ARG A 1 107 ? 93.413  105.417 109.409 1.00 78.61  ? 107 ARG A O   1 
ATOM 672  C CB  . ARG A 1 107 ? 94.921  104.290 106.787 1.00 78.61  ? 107 ARG A CB  1 
ATOM 673  C CG  . ARG A 1 107 ? 95.082  102.956 106.085 1.00 78.61  ? 107 ARG A CG  1 
ATOM 674  C CD  . ARG A 1 107 ? 96.545  102.638 105.874 1.00 78.61  ? 107 ARG A CD  1 
ATOM 675  N NE  . ARG A 1 107 ? 97.230  102.448 107.146 1.00 78.61  ? 107 ARG A NE  1 
ATOM 676  C CZ  . ARG A 1 107 ? 97.213  101.323 107.846 1.00 78.61  ? 107 ARG A CZ  1 
ATOM 677  N NH1 . ARG A 1 107 ? 96.572  100.249 107.414 1.00 78.61  ? 107 ARG A NH1 1 
ATOM 678  N NH2 . ARG A 1 107 ? 97.851  101.275 109.012 1.00 78.61  ? 107 ARG A NH2 1 
ATOM 679  N N   . SER A 1 108 ? 93.398  106.980 107.786 1.00 80.11  ? 108 SER A N   1 
ATOM 680  C CA  . SER A 1 108 ? 93.362  108.087 108.736 1.00 80.11  ? 108 SER A CA  1 
ATOM 681  C C   . SER A 1 108 ? 92.045  108.121 109.499 1.00 80.11  ? 108 SER A C   1 
ATOM 682  O O   . SER A 1 108 ? 92.026  108.386 110.707 1.00 80.11  ? 108 SER A O   1 
ATOM 683  C CB  . SER A 1 108 ? 93.596  109.409 108.005 1.00 80.11  ? 108 SER A CB  1 
ATOM 684  O OG  . SER A 1 108 ? 93.623  110.498 108.909 1.00 80.11  ? 108 SER A OG  1 
ATOM 685  N N   . LYS A 1 109 ? 90.932  107.859 108.814 1.00 80.01  ? 109 LYS A N   1 
ATOM 686  C CA  . LYS A 1 109 ? 89.635  107.852 109.476 1.00 80.01  ? 109 LYS A CA  1 
ATOM 687  C C   . LYS A 1 109 ? 89.357  106.558 110.230 1.00 80.01  ? 109 LYS A C   1 
ATOM 688  O O   . LYS A 1 109 ? 88.353  106.482 110.945 1.00 80.01  ? 109 LYS A O   1 
ATOM 689  C CB  . LYS A 1 109 ? 88.524  108.114 108.458 1.00 80.01  ? 109 LYS A CB  1 
ATOM 690  C CG  . LYS A 1 109 ? 88.568  109.506 107.847 1.00 80.01  ? 109 LYS A CG  1 
ATOM 691  C CD  . LYS A 1 109 ? 87.437  109.720 106.855 1.00 80.01  ? 109 LYS A CD  1 
ATOM 692  C CE  . LYS A 1 109 ? 87.433  111.141 106.316 1.00 80.01  ? 109 LYS A CE  1 
ATOM 693  N NZ  . LYS A 1 109 ? 88.631  111.423 105.478 1.00 80.01  ? 109 LYS A NZ  1 
ATOM 694  N N   . GLY A 1 110 ? 90.213  105.546 110.092 1.00 81.08  ? 110 GLY A N   1 
ATOM 695  C CA  . GLY A 1 110 ? 90.087  104.335 110.876 1.00 81.08  ? 110 GLY A CA  1 
ATOM 696  C C   . GLY A 1 110 ? 89.094  103.318 110.365 1.00 81.08  ? 110 GLY A C   1 
ATOM 697  O O   . GLY A 1 110 ? 88.614  102.499 111.156 1.00 81.08  ? 110 GLY A O   1 
ATOM 698  N N   . TYR A 1 111 ? 88.760  103.346 109.077 1.00 80.09  ? 111 TYR A N   1 
ATOM 699  C CA  . TYR A 1 111 ? 87.824  102.375 108.528 1.00 80.09  ? 111 TYR A CA  1 
ATOM 700  C C   . TYR A 1 111 ? 88.446  100.985 108.477 1.00 80.09  ? 111 TYR A C   1 
ATOM 701  O O   . TYR A 1 111 ? 89.661  100.832 108.328 1.00 80.09  ? 111 TYR A O   1 
ATOM 702  C CB  . TYR A 1 111 ? 87.377  102.798 107.129 1.00 80.09  ? 111 TYR A CB  1 
ATOM 703  C CG  . TYR A 1 111 ? 86.613  104.102 107.092 1.00 80.09  ? 111 TYR A CG  1 
ATOM 704  C CD1 . TYR A 1 111 ? 85.441  104.263 107.816 1.00 80.09  ? 111 TYR A CD1 1 
ATOM 705  C CD2 . TYR A 1 111 ? 87.063  105.170 106.330 1.00 80.09  ? 111 TYR A CD2 1 
ATOM 706  C CE1 . TYR A 1 111 ? 84.740  105.451 107.781 1.00 80.09  ? 111 TYR A CE1 1 
ATOM 707  C CE2 . TYR A 1 111 ? 86.367  106.360 106.285 1.00 80.09  ? 111 TYR A CE2 1 
ATOM 708  C CZ  . TYR A 1 111 ? 85.208  106.497 107.014 1.00 80.09  ? 111 TYR A CZ  1 
ATOM 709  O OH  . TYR A 1 111 ? 84.513  107.683 106.975 1.00 80.09  ? 111 TYR A OH  1 
ATOM 710  N N   . VAL A 1 112 ? 87.597  99.966  108.613 1.00 80.26  ? 112 VAL A N   1 
ATOM 711  C CA  . VAL A 1 112 ? 88.034  98.579  108.512 1.00 80.26  ? 112 VAL A CA  1 
ATOM 712  C C   . VAL A 1 112 ? 87.413  97.877  107.304 1.00 80.26  ? 112 VAL A C   1 
ATOM 713  O O   . VAL A 1 112 ? 87.962  96.868  106.835 1.00 80.26  ? 112 VAL A O   1 
ATOM 714  C CB  . VAL A 1 112 ? 87.707  97.823  109.822 1.00 80.26  ? 112 VAL A CB  1 
ATOM 715  C CG1 . VAL A 1 112 ? 86.197  97.726  110.034 1.00 80.26  ? 112 VAL A CG1 1 
ATOM 716  C CG2 . VAL A 1 112 ? 88.392  96.455  109.893 1.00 80.26  ? 112 VAL A CG2 1 
ATOM 717  N N   . THR A 1 113 ? 86.325  98.410  106.752 1.00 77.97  ? 113 THR A N   1 
ATOM 718  C CA  . THR A 1 113 ? 85.613  97.787  105.647 1.00 77.97  ? 113 THR A CA  1 
ATOM 719  C C   . THR A 1 113 ? 85.332  98.863  104.602 1.00 77.97  ? 113 THR A C   1 
ATOM 720  O O   . THR A 1 113 ? 85.210  100.046 104.926 1.00 77.97  ? 113 THR A O   1 
ATOM 721  C CB  . THR A 1 113 ? 84.319  97.116  106.155 1.00 77.97  ? 113 THR A CB  1 
ATOM 722  O OG1 . THR A 1 113 ? 84.651  96.170  107.178 1.00 77.97  ? 113 THR A OG1 1 
ATOM 723  C CG2 . THR A 1 113 ? 83.586  96.369  105.048 1.00 77.97  ? 113 THR A CG2 1 
ATOM 724  N N   . MET A 1 114 ? 85.267  98.444  103.332 1.00 68.30  ? 114 MET A N   1 
ATOM 725  C CA  . MET A 1 114 ? 85.039  99.389  102.241 1.00 68.30  ? 114 MET A CA  1 
ATOM 726  C C   . MET A 1 114 ? 83.667  100.044 102.349 1.00 68.30  ? 114 MET A C   1 
ATOM 727  O O   . MET A 1 114 ? 83.517  101.237 102.059 1.00 68.30  ? 114 MET A O   1 
ATOM 728  C CB  . MET A 1 114 ? 85.201  98.677  100.893 1.00 68.30  ? 114 MET A CB  1 
ATOM 729  C CG  . MET A 1 114 ? 85.060  99.558  99.643  1.00 68.30  ? 114 MET A CG  1 
ATOM 730  S SD  . MET A 1 114 ? 83.399  99.930  99.043  1.00 68.30  ? 114 MET A SD  1 
ATOM 731  C CE  . MET A 1 114 ? 82.923  98.345  98.364  1.00 68.30  ? 114 MET A CE  1 
ATOM 732  N N   . LEU A 1 115 ? 82.652  99.281  102.745 1.00 70.20  ? 115 LEU A N   1 
ATOM 733  C CA  . LEU A 1 115 ? 81.291  99.791  102.847 1.00 70.20  ? 115 LEU A CA  1 
ATOM 734  C C   . LEU A 1 115 ? 80.979  100.341 104.237 1.00 70.20  ? 115 LEU A C   1 
ATOM 735  O O   . LEU A 1 115 ? 79.898  100.900 104.443 1.00 70.20  ? 115 LEU A O   1 
ATOM 736  C CB  . LEU A 1 115 ? 80.313  98.681  102.419 1.00 70.20  ? 115 LEU A CB  1 
ATOM 737  C CG  . LEU A 1 115 ? 78.802  98.833  102.218 1.00 70.20  ? 115 LEU A CG  1 
ATOM 738  C CD1 . LEU A 1 115 ? 78.358  97.808  101.209 1.00 70.20  ? 115 LEU A CD1 1 
ATOM 739  C CD2 . LEU A 1 115 ? 78.039  98.576  103.499 1.00 70.20  ? 115 LEU A CD2 1 
ATOM 740  N N   . ASP A 1 116 ? 81.924  100.244 105.171 1.00 72.71  ? 116 ASP A N   1 
ATOM 741  C CA  . ASP A 1 116 ? 81.771  100.894 106.471 1.00 72.71  ? 116 ASP A CA  1 
ATOM 742  C C   . ASP A 1 116 ? 81.572  102.411 106.392 1.00 72.71  ? 116 ASP A C   1 
ATOM 743  O O   . ASP A 1 116 ? 80.749  102.926 107.170 1.00 72.71  ? 116 ASP A O   1 
ATOM 744  C CB  . ASP A 1 116 ? 82.972  100.520 107.361 1.00 72.71  ? 116 ASP A CB  1 
ATOM 745  C CG  . ASP A 1 116 ? 82.876  101.084 108.776 1.00 72.71  ? 116 ASP A CG  1 
ATOM 746  O OD1 . ASP A 1 116 ? 82.976  102.316 108.967 1.00 72.71  ? 116 ASP A OD1 1 
ATOM 747  O OD2 . ASP A 1 116 ? 82.698  100.278 109.712 1.00 72.71  ? 116 ASP A OD2 1 
ATOM 748  N N   . PRO A 1 117 ? 82.288  103.182 105.545 1.00 68.75  ? 117 PRO A N   1 
ATOM 749  C CA  . PRO A 1 117 ? 81.988  104.626 105.471 1.00 68.75  ? 117 PRO A CA  1 
ATOM 750  C C   . PRO A 1 117 ? 80.554  104.944 105.086 1.00 68.75  ? 117 PRO A C   1 
ATOM 751  O O   . PRO A 1 117 ? 79.996  105.934 105.572 1.00 68.75  ? 117 PRO A O   1 
ATOM 752  C CB  . PRO A 1 117 ? 82.972  105.134 104.410 1.00 68.75  ? 117 PRO A CB  1 
ATOM 753  C CG  . PRO A 1 117 ? 84.098  104.215 104.473 1.00 68.75  ? 117 PRO A CG  1 
ATOM 754  C CD  . PRO A 1 117 ? 83.535  102.872 104.814 1.00 68.75  ? 117 PRO A CD  1 
ATOM 755  N N   . PHE A 1 118 ? 79.942  104.141 104.213 1.00 63.87  ? 118 PHE A N   1 
ATOM 756  C CA  . PHE A 1 118 ? 78.543  104.367 103.867 1.00 63.87  ? 118 PHE A CA  1 
ATOM 757  C C   . PHE A 1 118 ? 77.636  104.139 105.068 1.00 63.87  ? 118 PHE A C   1 
ATOM 758  O O   . PHE A 1 118 ? 76.700  104.911 105.304 1.00 63.87  ? 118 PHE A O   1 
ATOM 759  C CB  . PHE A 1 118 ? 78.137  103.465 102.704 1.00 63.87  ? 118 PHE A CB  1 
ATOM 760  C CG  . PHE A 1 118 ? 78.967  103.660 101.473 1.00 63.87  ? 118 PHE A CG  1 
ATOM 761  C CD1 . PHE A 1 118 ? 79.290  104.933 101.035 1.00 63.87  ? 118 PHE A CD1 1 
ATOM 762  C CD2 . PHE A 1 118 ? 79.429  102.573 100.755 1.00 63.87  ? 118 PHE A CD2 1 
ATOM 763  C CE1 . PHE A 1 118 ? 80.056  105.116 99.903  1.00 63.87  ? 118 PHE A CE1 1 
ATOM 764  C CE2 . PHE A 1 118 ? 80.196  102.750 99.622  1.00 63.87  ? 118 PHE A CE2 1 
ATOM 765  C CZ  . PHE A 1 118 ? 80.509  104.024 99.196  1.00 63.87  ? 118 PHE A CZ  1 
ATOM 766  N N   . GLN A 1 119 ? 77.910  103.093 105.850 1.00 73.90  ? 119 GLN A N   1 
ATOM 767  C CA  . GLN A 1 119 ? 77.063  102.785 106.997 1.00 73.90  ? 119 GLN A CA  1 
ATOM 768  C C   . GLN A 1 119 ? 77.231  103.811 108.109 1.00 73.90  ? 119 GLN A C   1 
ATOM 769  O O   . GLN A 1 119 ? 76.286  104.074 108.863 1.00 73.90  ? 119 GLN A O   1 
ATOM 770  C CB  . GLN A 1 119 ? 77.368  101.381 107.515 1.00 73.90  ? 119 GLN A CB  1 
ATOM 771  C CG  . GLN A 1 119 ? 76.968  100.276 106.559 1.00 73.90  ? 119 GLN A CG  1 
ATOM 772  C CD  . GLN A 1 119 ? 76.266  99.130  107.256 1.00 73.90  ? 119 GLN A CD  1 
ATOM 773  O OE1 . GLN A 1 119 ? 76.513  98.857  108.429 1.00 73.90  ? 119 GLN A OE1 1 
ATOM 774  N NE2 . GLN A 1 119 ? 75.383  98.452  106.533 1.00 73.90  ? 119 GLN A NE2 1 
ATOM 775  N N   . GLN A 1 120 ? 78.427  104.389 108.242 1.00 75.16  ? 120 GLN A N   1 
ATOM 776  C CA  . GLN A 1 120 ? 78.661  105.339 109.327 1.00 75.16  ? 120 GLN A CA  1 
ATOM 777  C C   . GLN A 1 120 ? 77.864  106.626 109.128 1.00 75.16  ? 120 GLN A C   1 
ATOM 778  O O   . GLN A 1 120 ? 77.195  107.102 110.052 1.00 75.16  ? 120 GLN A O   1 
ATOM 779  C CB  . GLN A 1 120 ? 80.152  105.645 109.457 1.00 75.16  ? 120 GLN A CB  1 
ATOM 780  C CG  . GLN A 1 120 ? 80.472  106.563 110.631 1.00 75.16  ? 120 GLN A CG  1 
ATOM 781  C CD  . GLN A 1 120 ? 81.954  106.818 110.793 1.00 75.16  ? 120 GLN A CD  1 
ATOM 782  O OE1 . GLN A 1 120 ? 82.765  106.339 110.005 1.00 75.16  ? 120 GLN A OE1 1 
ATOM 783  N NE2 . GLN A 1 120 ? 82.316  107.579 111.818 1.00 75.16  ? 120 GLN A NE2 1 
ATOM 784  N N   . ILE A 1 121 ? 77.920  107.203 107.928 1.00 70.70  ? 121 ILE A N   1 
ATOM 785  C CA  . ILE A 1 121 ? 77.227  108.466 107.678 1.00 70.70  ? 121 ILE A CA  1 
ATOM 786  C C   . ILE A 1 121 ? 75.797  108.223 107.207 1.00 70.70  ? 121 ILE A C   1 
ATOM 787  O O   . ILE A 1 121 ? 74.836  108.696 107.823 1.00 70.70  ? 121 ILE A O   1 
ATOM 788  C CB  . ILE A 1 121 ? 78.005  109.343 106.675 1.00 70.70  ? 121 ILE A CB  1 
ATOM 789  C CG1 . ILE A 1 121 ? 79.384  109.758 107.213 1.00 70.70  ? 121 ILE A CG1 1 
ATOM 790  C CG2 . ILE A 1 121 ? 77.192  110.573 106.300 1.00 70.70  ? 121 ILE A CG2 1 
ATOM 791  C CD1 . ILE A 1 121 ? 80.526  108.811 106.916 1.00 70.70  ? 121 ILE A CD1 1 
ATOM 792  N N   . TYR A 1 122 ? 75.635  107.489 106.102 1.00 64.26  ? 122 TYR A N   1 
ATOM 793  C CA  . TYR A 1 122 ? 74.319  107.380 105.481 1.00 64.26  ? 122 TYR A CA  1 
ATOM 794  C C   . TYR A 1 122 ? 73.375  106.482 106.273 1.00 64.26  ? 122 TYR A C   1 
ATOM 795  O O   . TYR A 1 122 ? 72.153  106.640 106.180 1.00 64.26  ? 122 TYR A O   1 
ATOM 796  C CB  . TYR A 1 122 ? 74.456  106.867 104.048 1.00 64.26  ? 122 TYR A CB  1 
ATOM 797  C CG  . TYR A 1 122 ? 75.270  107.763 103.143 1.00 64.26  ? 122 TYR A CG  1 
ATOM 798  C CD1 . TYR A 1 122 ? 75.304  109.138 103.340 1.00 64.26  ? 122 TYR A CD1 1 
ATOM 799  C CD2 . TYR A 1 122 ? 75.990  107.236 102.080 1.00 64.26  ? 122 TYR A CD2 1 
ATOM 800  C CE1 . TYR A 1 122 ? 76.044  109.960 102.512 1.00 64.26  ? 122 TYR A CE1 1 
ATOM 801  C CE2 . TYR A 1 122 ? 76.730  108.051 101.246 1.00 64.26  ? 122 TYR A CE2 1 
ATOM 802  C CZ  . TYR A 1 122 ? 76.752  109.412 101.466 1.00 64.26  ? 122 TYR A CZ  1 
ATOM 803  O OH  . TYR A 1 122 ? 77.488  110.225 100.638 1.00 64.26  ? 122 TYR A OH  1 
ATOM 804  N N   . GLY A 1 123 ? 73.908  105.547 107.051 1.00 72.58  ? 123 GLY A N   1 
ATOM 805  C CA  . GLY A 1 123 ? 73.086  104.629 107.809 1.00 72.58  ? 123 GLY A CA  1 
ATOM 806  C C   . GLY A 1 123 ? 73.057  103.233 107.211 1.00 72.58  ? 123 GLY A C   1 
ATOM 807  O O   . GLY A 1 123 ? 73.574  102.965 106.125 1.00 72.58  ? 123 GLY A O   1 
ATOM 808  N N   . LYS A 1 124 ? 72.426  102.320 107.955 1.00 79.05  ? 124 LYS A N   1 
ATOM 809  C CA  . LYS A 1 124 ? 72.423  100.914 107.564 1.00 79.05  ? 124 LYS A CA  1 
ATOM 810  C C   . LYS A 1 124 ? 71.468  100.637 106.408 1.00 79.05  ? 124 LYS A C   1 
ATOM 811  O O   . LYS A 1 124 ? 71.769  99.801  105.549 1.00 79.05  ? 124 LYS A O   1 
ATOM 812  C CB  . LYS A 1 124 ? 72.069  100.039 108.766 1.00 79.05  ? 124 LYS A CB  1 
ATOM 813  C CG  . LYS A 1 124 ? 72.776  100.445 110.048 1.00 79.05  ? 124 LYS A CG  1 
ATOM 814  C CD  . LYS A 1 124 ? 73.893  99.476  110.398 1.00 79.05  ? 124 LYS A CD  1 
ATOM 815  C CE  . LYS A 1 124 ? 74.283  99.588  111.861 1.00 79.05  ? 124 LYS A CE  1 
ATOM 816  N NZ  . LYS A 1 124 ? 75.059  98.404  112.321 1.00 79.05  ? 124 LYS A NZ  1 
ATOM 817  N N   . ARG A 1 125 ? 70.316  101.311 106.368 1.00 78.83  ? 125 ARG A N   1 
ATOM 818  C CA  . ARG A 1 125 ? 69.378  101.093 105.270 1.00 78.83  ? 125 ARG A CA  1 
ATOM 819  C C   . ARG A 1 125 ? 69.925  101.647 103.959 1.00 78.83  ? 125 ARG A C   1 
ATOM 820  O O   . ARG A 1 125 ? 69.879  100.973 102.921 1.00 78.83  ? 125 ARG A O   1 
ATOM 821  C CB  . ARG A 1 125 ? 68.024  101.717 105.604 1.00 78.83  ? 125 ARG A CB  1 
ATOM 822  C CG  . ARG A 1 125 ? 66.927  101.393 104.606 1.00 78.83  ? 125 ARG A CG  1 
ATOM 823  C CD  . ARG A 1 125 ? 65.594  101.179 105.306 1.00 78.83  ? 125 ARG A CD  1 
ATOM 824  N NE  . ARG A 1 125 ? 65.087  102.403 105.915 1.00 78.83  ? 125 ARG A NE  1 
ATOM 825  C CZ  . ARG A 1 125 ? 64.214  103.220 105.342 1.00 78.83  ? 125 ARG A CZ  1 
ATOM 826  N NH1 . ARG A 1 125 ? 63.728  102.977 104.136 1.00 78.83  ? 125 ARG A NH1 1 
ATOM 827  N NH2 . ARG A 1 125 ? 63.819  104.309 105.995 1.00 78.83  ? 125 ARG A NH2 1 
ATOM 828  N N   . MET A 1 126 ? 70.467  102.866 103.987 1.00 74.77  ? 126 MET A N   1 
ATOM 829  C CA  . MET A 1 126 ? 71.172  103.372 102.817 1.00 74.77  ? 126 MET A CA  1 
ATOM 830  C C   . MET A 1 126 ? 72.458  102.593 102.571 1.00 74.77  ? 126 MET A C   1 
ATOM 831  O O   . MET A 1 126 ? 72.921  102.512 101.428 1.00 74.77  ? 126 MET A O   1 
ATOM 832  C CB  . MET A 1 126 ? 71.461  104.866 102.977 1.00 74.77  ? 126 MET A CB  1 
ATOM 833  C CG  . MET A 1 126 ? 72.014  105.527 101.725 1.00 74.77  ? 126 MET A CG  1 
ATOM 834  S SD  . MET A 1 126 ? 70.817  105.558 100.380 1.00 74.77  ? 126 MET A SD  1 
ATOM 835  C CE  . MET A 1 126 ? 71.903  105.498 98.957  1.00 74.77  ? 126 MET A CE  1 
ATOM 836  N N   . GLY A 1 127 ? 73.022  101.991 103.620 1.00 73.15  ? 127 GLY A N   1 
ATOM 837  C CA  . GLY A 1 127 ? 74.127  101.067 103.425 1.00 73.15  ? 127 GLY A CA  1 
ATOM 838  C C   . GLY A 1 127 ? 73.741  99.886  102.556 1.00 73.15  ? 127 GLY A C   1 
ATOM 839  O O   . GLY A 1 127 ? 74.474  99.509  101.646 1.00 73.15  ? 127 GLY A O   1 
ATOM 840  N N   . GLY A 1 128 ? 72.568  99.304  102.810 1.00 68.87  ? 128 GLY A N   1 
ATOM 841  C CA  . GLY A 1 128 ? 72.077  98.238  101.946 1.00 68.87  ? 128 GLY A CA  1 
ATOM 842  C C   . GLY A 1 128 ? 71.702  98.727  100.558 1.00 68.87  ? 128 GLY A C   1 
ATOM 843  O O   . GLY A 1 128 ? 71.897  98.022  99.558  1.00 68.87  ? 128 GLY A O   1 
ATOM 844  N N   . LEU A 1 129 ? 71.143  99.937  100.479 1.00 66.59  ? 129 LEU A N   1 
ATOM 845  C CA  . LEU A 1 129 ? 70.772  100.503 99.185  1.00 66.59  ? 129 LEU A CA  1 
ATOM 846  C C   . LEU A 1 129 ? 71.997  100.718 98.301  1.00 66.59  ? 129 LEU A C   1 
ATOM 847  O O   . LEU A 1 129 ? 71.932  100.513 97.085  1.00 66.59  ? 129 LEU A O   1 
ATOM 848  C CB  . LEU A 1 129 ? 70.010  101.812 99.385  1.00 66.59  ? 129 LEU A CB  1 
ATOM 849  C CG  . LEU A 1 129 ? 69.044  102.238 98.276  1.00 66.59  ? 129 LEU A CG  1 
ATOM 850  C CD1 . LEU A 1 129 ? 68.254  101.049 97.753  1.00 66.59  ? 129 LEU A CD1 1 
ATOM 851  C CD2 . LEU A 1 129 ? 68.106  103.326 98.776  1.00 66.59  ? 129 LEU A CD2 1 
ATOM 852  N N   . LEU A 1 130 ? 73.115  101.145 98.891  1.00 64.07  ? 130 LEU A N   1 
ATOM 853  C CA  . LEU A 1 130 ? 74.389  101.213 98.181  1.00 64.07  ? 130 LEU A CA  1 
ATOM 854  C C   . LEU A 1 130 ? 75.038  99.845  98.020  1.00 64.07  ? 130 LEU A C   1 
ATOM 855  O O   . LEU A 1 130 ? 75.847  99.655  97.107  1.00 64.07  ? 130 LEU A O   1 
ATOM 856  C CB  . LEU A 1 130 ? 75.346  102.149 98.917  1.00 64.07  ? 130 LEU A CB  1 
ATOM 857  C CG  . LEU A 1 130 ? 75.272  103.621 98.523  1.00 64.07  ? 130 LEU A CG  1 
ATOM 858  C CD1 . LEU A 1 130 ? 75.806  104.503 99.638  1.00 64.07  ? 130 LEU A CD1 1 
ATOM 859  C CD2 . LEU A 1 130 ? 76.052  103.833 97.249  1.00 64.07  ? 130 LEU A CD2 1 
ATOM 860  N N   . PHE A 1 131 ? 74.706  98.905  98.904  1.00 69.67  ? 131 PHE A N   1 
ATOM 861  C CA  . PHE A 1 131 ? 75.225  97.547  98.831  1.00 69.67  ? 131 PHE A CA  1 
ATOM 862  C C   . PHE A 1 131 ? 74.737  96.835  97.579  1.00 69.67  ? 131 PHE A C   1 
ATOM 863  O O   . PHE A 1 131 ? 75.463  96.024  96.994  1.00 69.67  ? 131 PHE A O   1 
ATOM 864  C CB  . PHE A 1 131 ? 74.783  96.795  100.086 1.00 69.67  ? 131 PHE A CB  1 
ATOM 865  C CG  . PHE A 1 131 ? 75.158  95.352  100.110 1.00 69.67  ? 131 PHE A CG  1 
ATOM 866  C CD1 . PHE A 1 131 ? 76.391  94.959  100.575 1.00 69.67  ? 131 PHE A CD1 1 
ATOM 867  C CD2 . PHE A 1 131 ? 74.276  94.384  99.661  1.00 69.67  ? 131 PHE A CD2 1 
ATOM 868  C CE1 . PHE A 1 131 ? 76.727  93.639  100.612 1.00 69.67  ? 131 PHE A CE1 1 
ATOM 869  C CE2 . PHE A 1 131 ? 74.623  93.063  99.682  1.00 69.67  ? 131 PHE A CE2 1 
ATOM 870  C CZ  . PHE A 1 131 ? 75.850  92.692  100.152 1.00 69.67  ? 131 PHE A CZ  1 
ATOM 871  N N   . ILE A 1 132 ? 73.483  97.085  97.195  1.00 61.66  ? 132 ILE A N   1 
ATOM 872  C CA  . ILE A 1 132 ? 72.899  96.374  96.052  1.00 61.66  ? 132 ILE A CA  1 
ATOM 873  C C   . ILE A 1 132 ? 73.687  96.581  94.757  1.00 61.66  ? 132 ILE A C   1 
ATOM 874  O O   . ILE A 1 132 ? 73.934  95.590  94.049  1.00 61.66  ? 132 ILE A O   1 
ATOM 875  C CB  . ILE A 1 132 ? 71.406  96.727  95.920  1.00 61.66  ? 132 ILE A CB  1 
ATOM 876  C CG1 . ILE A 1 132 ? 70.621  96.146  97.096  1.00 61.66  ? 132 ILE A CG1 1 
ATOM 877  C CG2 . ILE A 1 132 ? 70.833  96.212  94.614  1.00 61.66  ? 132 ILE A CG2 1 
ATOM 878  C CD1 . ILE A 1 132 ? 69.208  96.664  97.195  1.00 61.66  ? 132 ILE A CD1 1 
ATOM 879  N N   . PRO A 1 133 ? 74.113  97.805  94.384  1.00 56.57  ? 133 PRO A N   1 
ATOM 880  C CA  . PRO A 1 133 ? 75.039  97.910  93.239  1.00 56.57  ? 133 PRO A CA  1 
ATOM 881  C C   . PRO A 1 133 ? 76.366  97.201  93.452  1.00 56.57  ? 133 PRO A C   1 
ATOM 882  O O   . PRO A 1 133 ? 76.935  96.673  92.490  1.00 56.57  ? 133 PRO A O   1 
ATOM 883  C CB  . PRO A 1 133 ? 75.227  99.424  93.078  1.00 56.57  ? 133 PRO A CB  1 
ATOM 884  C CG  . PRO A 1 133 ? 74.007  100.009 93.635  1.00 56.57  ? 133 PRO A CG  1 
ATOM 885  C CD  . PRO A 1 133 ? 73.645  99.144  94.793  1.00 56.57  ? 133 PRO A CD  1 
ATOM 886  N N   . ALA A 1 134 ? 76.882  97.179  94.684  1.00 56.58  ? 134 ALA A N   1 
ATOM 887  C CA  . ALA A 1 134 ? 78.102  96.426  94.960  1.00 56.58  ? 134 ALA A CA  1 
ATOM 888  C C   . ALA A 1 134 ? 77.876  94.932  94.763  1.00 56.58  ? 134 ALA A C   1 
ATOM 889  O O   . ALA A 1 134 ? 78.734  94.232  94.212  1.00 56.58  ? 134 ALA A O   1 
ATOM 890  C CB  . ALA A 1 134 ? 78.593  96.718  96.378  1.00 56.58  ? 134 ALA A CB  1 
ATOM 891  N N   . LEU A 1 135 ? 76.717  94.430  95.201  1.00 55.95  ? 135 LEU A N   1 
ATOM 892  C CA  . LEU A 1 135 ? 76.372  93.030  94.973  1.00 55.95  ? 135 LEU A CA  1 
ATOM 893  C C   . LEU A 1 135 ? 76.275  92.729  93.486  1.00 55.95  ? 135 LEU A C   1 
ATOM 894  O O   . LEU A 1 135 ? 76.744  91.686  93.022  1.00 55.95  ? 135 LEU A O   1 
ATOM 895  C CB  . LEU A 1 135 ? 75.054  92.687  95.676  1.00 55.95  ? 135 LEU A CB  1 
ATOM 896  C CG  . LEU A 1 135 ? 74.544  91.238  95.741  1.00 55.95  ? 135 LEU A CG  1 
ATOM 897  C CD1 . LEU A 1 135 ? 73.677  91.071  96.958  1.00 55.95  ? 135 LEU A CD1 1 
ATOM 898  C CD2 . LEU A 1 135 ? 73.736  90.830  94.512  1.00 55.95  ? 135 LEU A CD2 1 
ATOM 899  N N   . MET A 1 136 ? 75.648  93.626  92.723  1.00 50.60  ? 136 MET A N   1 
ATOM 900  C CA  . MET A 1 136 ? 75.520  93.391  91.290  1.00 50.60  ? 136 MET A CA  1 
ATOM 901  C C   . MET A 1 136 ? 76.869  93.452  90.585  1.00 50.60  ? 136 MET A C   1 
ATOM 902  O O   . MET A 1 136 ? 77.105  92.682  89.653  1.00 50.60  ? 136 MET A O   1 
ATOM 903  C CB  . MET A 1 136 ? 74.527  94.380  90.682  1.00 50.60  ? 136 MET A CB  1 
ATOM 904  C CG  . MET A 1 136 ? 73.112  93.816  90.603  1.00 50.60  ? 136 MET A CG  1 
ATOM 905  S SD  . MET A 1 136 ? 71.860  94.948  89.970  1.00 50.60  ? 136 MET A SD  1 
ATOM 906  C CE  . MET A 1 136 ? 72.011  96.306  91.124  1.00 50.60  ? 136 MET A CE  1 
ATOM 907  N N   . GLY A 1 137 ? 77.771  94.329  91.028  1.00 45.64  ? 137 GLY A N   1 
ATOM 908  C CA  . GLY A 1 137 ? 79.116  94.336  90.473  1.00 45.64  ? 137 GLY A CA  1 
ATOM 909  C C   . GLY A 1 137 ? 79.880  93.064  90.785  1.00 45.64  ? 137 GLY A C   1 
ATOM 910  O O   . GLY A 1 137 ? 80.551  92.502  89.914  1.00 45.64  ? 137 GLY A O   1 
ATOM 911  N N   . GLU A 1 138 ? 79.777  92.583  92.031  1.00 49.23  ? 138 GLU A N   1 
ATOM 912  C CA  . GLU A 1 138 ? 80.397  91.312  92.397  1.00 49.23  ? 138 GLU A CA  1 
ATOM 913  C C   . GLU A 1 138 ? 79.817  90.164  91.584  1.00 49.23  ? 138 GLU A C   1 
ATOM 914  O O   . GLU A 1 138 ? 80.542  89.246  91.192  1.00 49.23  ? 138 GLU A O   1 
ATOM 915  C CB  . GLU A 1 138 ? 80.208  91.032  93.888  1.00 49.23  ? 138 GLU A CB  1 
ATOM 916  C CG  . GLU A 1 138 ? 80.922  91.977  94.840  1.00 49.23  ? 138 GLU A CG  1 
ATOM 917  C CD  . GLU A 1 138 ? 82.428  91.863  94.770  1.00 49.23  ? 138 GLU A CD  1 
ATOM 918  O OE1 . GLU A 1 138 ? 82.932  90.754  94.498  1.00 49.23  ? 138 GLU A OE1 1 
ATOM 919  O OE2 . GLU A 1 138 ? 83.108  92.882  95.015  1.00 49.23  ? 138 GLU A OE2 1 
ATOM 920  N N   . MET A 1 139 ? 78.512  90.205  91.317  1.00 44.29  ? 139 MET A N   1 
ATOM 921  C CA  . MET A 1 139 ? 77.863  89.140  90.560  1.00 44.29  ? 139 MET A CA  1 
ATOM 922  C C   . MET A 1 139 ? 78.254  89.182  89.086  1.00 44.29  ? 139 MET A C   1 
ATOM 923  O O   . MET A 1 139 ? 78.450  88.132  88.470  1.00 44.29  ? 139 MET A O   1 
ATOM 924  C CB  . MET A 1 139 ? 76.348  89.236  90.760  1.00 44.29  ? 139 MET A CB  1 
ATOM 925  C CG  . MET A 1 139 ? 75.487  88.163  90.100  1.00 44.29  ? 139 MET A CG  1 
ATOM 926  S SD  . MET A 1 139 ? 75.122  88.444  88.363  1.00 44.29  ? 139 MET A SD  1 
ATOM 927  C CE  . MET A 1 139 ? 73.965  89.803  88.521  1.00 44.29  ? 139 MET A CE  1 
ATOM 928  N N   . PHE A 1 140 ? 78.376  90.380  88.501  1.00 40.25  ? 140 PHE A N   1 
ATOM 929  C CA  . PHE A 1 140 ? 78.897  90.488  87.139  1.00 40.25  ? 140 PHE A CA  1 
ATOM 930  C C   . PHE A 1 140 ? 80.330  89.978  87.051  1.00 40.25  ? 140 PHE A C   1 
ATOM 931  O O   . PHE A 1 140 ? 80.683  89.275  86.095  1.00 40.25  ? 140 PHE A O   1 
ATOM 932  C CB  . PHE A 1 140 ? 78.863  91.936  86.646  1.00 40.25  ? 140 PHE A CB  1 
ATOM 933  C CG  . PHE A 1 140 ? 77.491  92.462  86.338  1.00 40.25  ? 140 PHE A CG  1 
ATOM 934  C CD1 . PHE A 1 140 ? 76.611  91.752  85.548  1.00 40.25  ? 140 PHE A CD1 1 
ATOM 935  C CD2 . PHE A 1 140 ? 77.102  93.705  86.809  1.00 40.25  ? 140 PHE A CD2 1 
ATOM 936  C CE1 . PHE A 1 140 ? 75.356  92.262  85.266  1.00 40.25  ? 140 PHE A CE1 1 
ATOM 937  C CE2 . PHE A 1 140 ? 75.852  94.209  86.535  1.00 40.25  ? 140 PHE A CE2 1 
ATOM 938  C CZ  . PHE A 1 140 ? 74.979  93.486  85.759  1.00 40.25  ? 140 PHE A CZ  1 
ATOM 939  N N   . TRP A 1 141 ? 81.161  90.318  88.039  1.00 35.97  ? 141 TRP A N   1 
ATOM 940  C CA  . TRP A 1 141 ? 82.545  89.856  88.052  1.00 35.97  ? 141 TRP A CA  1 
ATOM 941  C C   . TRP A 1 141 ? 82.618  88.337  88.194  1.00 35.97  ? 141 TRP A C   1 
ATOM 942  O O   . TRP A 1 141 ? 83.405  87.674  87.506  1.00 35.97  ? 141 TRP A O   1 
ATOM 943  C CB  . TRP A 1 141 ? 83.304  90.557  89.181  1.00 35.97  ? 141 TRP A CB  1 
ATOM 944  C CG  . TRP A 1 141 ? 84.772  90.250  89.251  1.00 35.97  ? 141 TRP A CG  1 
ATOM 945  C CD1 . TRP A 1 141 ? 85.447  89.742  90.319  1.00 35.97  ? 141 TRP A CD1 1 
ATOM 946  C CD2 . TRP A 1 141 ? 85.750  90.463  88.223  1.00 35.97  ? 141 TRP A CD2 1 
ATOM 947  N NE1 . TRP A 1 141 ? 86.778  89.606  90.018  1.00 35.97  ? 141 TRP A NE1 1 
ATOM 948  C CE2 . TRP A 1 141 ? 86.991  90.042  88.737  1.00 35.97  ? 141 TRP A CE2 1 
ATOM 949  C CE3 . TRP A 1 141 ? 85.696  90.959  86.916  1.00 35.97  ? 141 TRP A CE3 1 
ATOM 950  C CZ2 . TRP A 1 141 ? 88.166  90.102  87.993  1.00 35.97  ? 141 TRP A CZ2 1 
ATOM 951  C CZ3 . TRP A 1 141 ? 86.863  91.015  86.180  1.00 35.97  ? 141 TRP A CZ3 1 
ATOM 952  C CH2 . TRP A 1 141 ? 88.081  90.592  86.720  1.00 35.97  ? 141 TRP A CH2 1 
ATOM 953  N N   . ALA A 1 142 ? 81.784  87.766  89.068  1.00 33.22  ? 142 ALA A N   1 
ATOM 954  C CA  . ALA A 1 142 ? 81.755  86.318  89.241  1.00 33.22  ? 142 ALA A CA  1 
ATOM 955  C C   . ALA A 1 142 ? 81.198  85.612  88.015  1.00 33.22  ? 142 ALA A C   1 
ATOM 956  O O   . ALA A 1 142 ? 81.626  84.500  87.702  1.00 33.22  ? 142 ALA A O   1 
ATOM 957  C CB  . ALA A 1 142 ? 80.939  85.948  90.477  1.00 33.22  ? 142 ALA A CB  1 
ATOM 958  N N   . ALA A 1 143 ? 80.244  86.229  87.314  1.00 33.05  ? 143 ALA A N   1 
ATOM 959  C CA  . ALA A 1 143 ? 79.758  85.660  86.064  1.00 33.05  ? 143 ALA A CA  1 
ATOM 960  C C   . ALA A 1 143 ? 80.835  85.672  84.992  1.00 33.05  ? 143 ALA A C   1 
ATOM 961  O O   . ALA A 1 143 ? 80.943  84.718  84.218  1.00 33.05  ? 143 ALA A O   1 
ATOM 962  C CB  . ALA A 1 143 ? 78.521  86.416  85.584  1.00 33.05  ? 143 ALA A CB  1 
ATOM 963  N N   . ALA A 1 144 ? 81.639  86.736  84.930  1.00 31.79  ? 144 ALA A N   1 
ATOM 964  C CA  . ALA A 1 144 ? 82.765  86.755  83.999  1.00 31.79  ? 144 ALA A CA  1 
ATOM 965  C C   . ALA A 1 144 ? 83.791  85.679  84.345  1.00 31.79  ? 144 ALA A C   1 
ATOM 966  O O   . ALA A 1 144 ? 84.317  85.004  83.451  1.00 31.79  ? 144 ALA A O   1 
ATOM 967  C CB  . ALA A 1 144 ? 83.417  88.136  83.991  1.00 31.79  ? 144 ALA A CB  1 
ATOM 968  N N   . ILE A 1 145 ? 84.079  85.502  85.637  1.00 31.91  ? 145 ILE A N   1 
ATOM 969  C CA  . ILE A 1 145 ? 85.018  84.465  86.063  1.00 31.91  ? 145 ILE A CA  1 
ATOM 970  C C   . ILE A 1 145 ? 84.479  83.075  85.735  1.00 31.91  ? 145 ILE A C   1 
ATOM 971  O O   . ILE A 1 145 ? 85.217  82.207  85.252  1.00 31.91  ? 145 ILE A O   1 
ATOM 972  C CB  . ILE A 1 145 ? 85.334  84.620  87.562  1.00 31.91  ? 145 ILE A CB  1 
ATOM 973  C CG1 . ILE A 1 145 ? 86.137  85.897  87.805  1.00 31.91  ? 145 ILE A CG1 1 
ATOM 974  C CG2 . ILE A 1 145 ? 86.097  83.418  88.086  1.00 31.91  ? 145 ILE A CG2 1 
ATOM 975  C CD1 . ILE A 1 145 ? 86.188  86.317  89.250  1.00 31.91  ? 145 ILE A CD1 1 
ATOM 976  N N   . PHE A 1 146 ? 83.187  82.843  85.986  1.00 32.37  ? 146 PHE A N   1 
ATOM 977  C CA  . PHE A 1 146 ? 82.566  81.566  85.652  1.00 32.37  ? 146 PHE A CA  1 
ATOM 978  C C   . PHE A 1 146 ? 82.561  81.314  84.154  1.00 32.37  ? 146 PHE A C   1 
ATOM 979  O O   . PHE A 1 146 ? 82.784  80.181  83.724  1.00 32.37  ? 146 PHE A O   1 
ATOM 980  C CB  . PHE A 1 146 ? 81.137  81.512  86.184  1.00 32.37  ? 146 PHE A CB  1 
ATOM 981  C CG  . PHE A 1 146 ? 81.043  81.155  87.633  1.00 32.37  ? 146 PHE A CG  1 
ATOM 982  C CD1 . PHE A 1 146 ? 82.000  80.351  88.224  1.00 32.37  ? 146 PHE A CD1 1 
ATOM 983  C CD2 . PHE A 1 146 ? 79.992  81.615  88.403  1.00 32.37  ? 146 PHE A CD2 1 
ATOM 984  C CE1 . PHE A 1 146 ? 81.913  80.021  89.557  1.00 32.37  ? 146 PHE A CE1 1 
ATOM 985  C CE2 . PHE A 1 146 ? 79.900  81.287  89.736  1.00 32.37  ? 146 PHE A CE2 1 
ATOM 986  C CZ  . PHE A 1 146 ? 80.860  80.488  90.312  1.00 32.37  ? 146 PHE A CZ  1 
ATOM 987  N N   . SER A 1 147 ? 82.299  82.347  83.350  1.00 32.29  ? 147 SER A N   1 
ATOM 988  C CA  . SER A 1 147 ? 82.345  82.198  81.901  1.00 32.29  ? 147 SER A CA  1 
ATOM 989  C C   . SER A 1 147 ? 83.747  81.845  81.426  1.00 32.29  ? 147 SER A C   1 
ATOM 990  O O   . SER A 1 147 ? 83.912  80.964  80.578  1.00 32.29  ? 147 SER A O   1 
ATOM 991  C CB  . SER A 1 147 ? 81.855  83.479  81.230  1.00 32.29  ? 147 SER A CB  1 
ATOM 992  O OG  . SER A 1 147 ? 82.032  83.423  79.827  1.00 32.29  ? 147 SER A OG  1 
ATOM 993  N N   . ALA A 1 148 ? 84.770  82.503  81.978  1.00 32.54  ? 148 ALA A N   1 
ATOM 994  C CA  . ALA A 1 148 ? 86.146  82.203  81.590  1.00 32.54  ? 148 ALA A CA  1 
ATOM 995  C C   . ALA A 1 148 ? 86.545  80.785  81.991  1.00 32.54  ? 148 ALA A C   1 
ATOM 996  O O   . ALA A 1 148 ? 87.159  80.053  81.202  1.00 32.54  ? 148 ALA A O   1 
ATOM 997  C CB  . ALA A 1 148 ? 87.095  83.226  82.212  1.00 32.54  ? 148 ALA A CB  1 
ATOM 998  N N   . LEU A 1 149 ? 86.203  80.381  83.217  1.00 35.53  ? 149 LEU A N   1 
ATOM 999  C CA  . LEU A 1 149 ? 86.551  79.046  83.695  1.00 35.53  ? 149 LEU A CA  1 
ATOM 1000 C C   . LEU A 1 149 ? 85.817  77.968  82.907  1.00 35.53  ? 149 LEU A C   1 
ATOM 1001 O O   . LEU A 1 149 ? 86.408  76.947  82.529  1.00 35.53  ? 149 LEU A O   1 
ATOM 1002 C CB  . LEU A 1 149 ? 86.242  78.937  85.188  1.00 35.53  ? 149 LEU A CB  1 
ATOM 1003 C CG  . LEU A 1 149 ? 86.265  77.550  85.824  1.00 35.53  ? 149 LEU A CG  1 
ATOM 1004 C CD1 . LEU A 1 149 ? 87.655  76.945  85.744  1.00 35.53  ? 149 LEU A CD1 1 
ATOM 1005 C CD2 . LEU A 1 149 ? 85.801  77.636  87.265  1.00 35.53  ? 149 LEU A CD2 1 
ATOM 1006 N N   . GLY A 1 150 ? 84.526  78.181  82.647  1.00 35.81  ? 150 GLY A N   1 
ATOM 1007 C CA  . GLY A 1 150 ? 83.776  77.244  81.833  1.00 35.81  ? 150 GLY A CA  1 
ATOM 1008 C C   . GLY A 1 150 ? 84.288  77.171  80.411  1.00 35.81  ? 150 GLY A C   1 
ATOM 1009 O O   . GLY A 1 150 ? 84.289  76.103  79.803  1.00 35.81  ? 150 GLY A O   1 
ATOM 1010 N N   . ALA A 1 151 ? 84.742  78.302  79.865  1.00 36.54  ? 151 ALA A N   1 
ATOM 1011 C CA  . ALA A 1 151 ? 85.329  78.302  78.530  1.00 36.54  ? 151 ALA A CA  1 
ATOM 1012 C C   . ALA A 1 151 ? 86.612  77.487  78.493  1.00 36.54  ? 151 ALA A C   1 
ATOM 1013 O O   . ALA A 1 151 ? 86.815  76.676  77.584  1.00 36.54  ? 151 ALA A O   1 
ATOM 1014 C CB  . ALA A 1 151 ? 85.592  79.737  78.078  1.00 36.54  ? 151 ALA A CB  1 
ATOM 1015 N N   . THR A 1 152 ? 87.484  77.679  79.484  1.00 36.36  ? 152 THR A N   1 
ATOM 1016 C CA  . THR A 1 152 ? 88.741  76.935  79.526  1.00 36.36  ? 152 THR A CA  1 
ATOM 1017 C C   . THR A 1 152 ? 88.490  75.437  79.674  1.00 36.36  ? 152 THR A C   1 
ATOM 1018 O O   . THR A 1 152 ? 89.111  74.613  78.983  1.00 36.36  ? 152 THR A O   1 
ATOM 1019 C CB  . THR A 1 152 ? 89.606  77.452  80.674  1.00 36.36  ? 152 THR A CB  1 
ATOM 1020 O OG1 . THR A 1 152 ? 89.571  78.884  80.692  1.00 36.36  ? 152 THR A OG1 1 
ATOM 1021 C CG2 . THR A 1 152 ? 91.032  77.007  80.490  1.00 36.36  ? 152 THR A CG2 1 
ATOM 1022 N N   . ILE A 1 153 ? 87.561  75.073  80.563  1.00 38.10  ? 153 ILE A N   1 
ATOM 1023 C CA  . ILE A 1 153 ? 87.221  73.670  80.779  1.00 38.10  ? 153 ILE A CA  1 
ATOM 1024 C C   . ILE A 1 153 ? 86.594  73.072  79.524  1.00 38.10  ? 153 ILE A C   1 
ATOM 1025 O O   . ILE A 1 153 ? 86.924  71.951  79.123  1.00 38.10  ? 153 ILE A O   1 
ATOM 1026 C CB  . ILE A 1 153 ? 86.302  73.541  82.008  1.00 38.10  ? 153 ILE A CB  1 
ATOM 1027 C CG1 . ILE A 1 153 ? 87.134  73.569  83.290  1.00 38.10  ? 153 ILE A CG1 1 
ATOM 1028 C CG2 . ILE A 1 153 ? 85.474  72.267  81.951  1.00 38.10  ? 153 ILE A CG2 1 
ATOM 1029 C CD1 . ILE A 1 153 ? 86.311  73.537  84.551  1.00 38.10  ? 153 ILE A CD1 1 
ATOM 1030 N N   . SER A 1 154 ? 85.699  73.818  78.870  1.00 41.40  ? 154 SER A N   1 
ATOM 1031 C CA  . SER A 1 154 ? 85.064  73.338  77.649  1.00 41.40  ? 154 SER A CA  1 
ATOM 1032 C C   . SER A 1 154 ? 86.051  73.222  76.500  1.00 41.40  ? 154 SER A C   1 
ATOM 1033 O O   . SER A 1 154 ? 85.811  72.467  75.554  1.00 41.40  ? 154 SER A O   1 
ATOM 1034 C CB  . SER A 1 154 ? 83.919  74.271  77.258  1.00 41.40  ? 154 SER A CB  1 
ATOM 1035 O OG  . SER A 1 154 ? 83.540  74.071  75.908  1.00 41.40  ? 154 SER A OG  1 
ATOM 1036 N N   . VAL A 1 155 ? 87.142  73.982  76.536  1.00 40.94  ? 155 VAL A N   1 
ATOM 1037 C CA  . VAL A 1 155 ? 88.141  73.860  75.482  1.00 40.94  ? 155 VAL A CA  1 
ATOM 1038 C C   . VAL A 1 155 ? 89.010  72.627  75.697  1.00 40.94  ? 155 VAL A C   1 
ATOM 1039 O O   . VAL A 1 155 ? 89.217  71.832  74.773  1.00 40.94  ? 155 VAL A O   1 
ATOM 1040 C CB  . VAL A 1 155 ? 88.980  75.146  75.380  1.00 40.94  ? 155 VAL A CB  1 
ATOM 1041 C CG1 . VAL A 1 155 ? 90.196  74.906  74.532  1.00 40.94  ? 155 VAL A CG1 1 
ATOM 1042 C CG2 . VAL A 1 155 ? 88.157  76.253  74.749  1.00 40.94  ? 155 VAL A CG2 1 
ATOM 1043 N N   . ILE A 1 156 ? 89.524  72.427  76.915  1.00 45.00  ? 156 ILE A N   1 
ATOM 1044 C CA  . ILE A 1 156 ? 90.487  71.339  77.108  1.00 45.00  ? 156 ILE A CA  1 
ATOM 1045 C C   . ILE A 1 156 ? 89.785  69.993  77.282  1.00 45.00  ? 156 ILE A C   1 
ATOM 1046 O O   . ILE A 1 156 ? 90.222  68.976  76.729  1.00 45.00  ? 156 ILE A O   1 
ATOM 1047 C CB  . ILE A 1 156 ? 91.452  71.651  78.267  1.00 45.00  ? 156 ILE A CB  1 
ATOM 1048 C CG1 . ILE A 1 156 ? 90.725  71.939  79.575  1.00 45.00  ? 156 ILE A CG1 1 
ATOM 1049 C CG2 . ILE A 1 156 ? 92.372  72.778  77.895  1.00 45.00  ? 156 ILE A CG2 1 
ATOM 1050 C CD1 . ILE A 1 156 ? 91.671  72.110  80.714  1.00 45.00  ? 156 ILE A CD1 1 
ATOM 1051 N N   . ILE A 1 157 ? 88.698  69.954  78.054  1.00 50.63  ? 157 ILE A N   1 
ATOM 1052 C CA  . ILE A 1 157 ? 87.965  68.705  78.231  1.00 50.63  ? 157 ILE A CA  1 
ATOM 1053 C C   . ILE A 1 157 ? 87.174  68.368  76.968  1.00 50.63  ? 157 ILE A C   1 
ATOM 1054 O O   . ILE A 1 157 ? 86.965  67.191  76.644  1.00 50.63  ? 157 ILE A O   1 
ATOM 1055 C CB  . ILE A 1 157 ? 87.068  68.801  79.481  1.00 50.63  ? 157 ILE A CB  1 
ATOM 1056 C CG1 . ILE A 1 157 ? 87.924  68.855  80.743  1.00 50.63  ? 157 ILE A CG1 1 
ATOM 1057 C CG2 . ILE A 1 157 ? 86.152  67.609  79.603  1.00 50.63  ? 157 ILE A CG2 1 
ATOM 1058 C CD1 . ILE A 1 157 ? 87.112  68.911  82.018  1.00 50.63  ? 157 ILE A CD1 1 
ATOM 1059 N N   . ASP A 1 158 ? 86.744  69.402  76.233  1.00 54.81  ? 158 ASP A N   1 
ATOM 1060 C CA  . ASP A 1 158 ? 85.992  69.350  74.973  1.00 54.81  ? 158 ASP A CA  1 
ATOM 1061 C C   . ASP A 1 158 ? 84.546  68.913  75.195  1.00 54.81  ? 158 ASP A C   1 
ATOM 1062 O O   . ASP A 1 158 ? 83.885  68.433  74.275  1.00 54.81  ? 158 ASP A O   1 
ATOM 1063 C CB  . ASP A 1 158 ? 86.691  68.473  73.919  1.00 54.81  ? 158 ASP A CB  1 
ATOM 1064 C CG  . ASP A 1 158 ? 86.376  68.889  72.485  1.00 54.81  ? 158 ASP A CG  1 
ATOM 1065 O OD1 . ASP A 1 158 ? 85.250  68.669  71.996  1.00 54.81  ? 158 ASP A OD1 1 
ATOM 1066 O OD2 . ASP A 1 158 ? 87.281  69.454  71.838  1.00 54.81  ? 158 ASP A OD2 1 
ATOM 1067 N N   . VAL A 1 159 ? 84.033  69.056  76.416  1.00 52.37  ? 159 VAL A N   1 
ATOM 1068 C CA  . VAL A 1 159 ? 82.599  68.952  76.672  1.00 52.37  ? 159 VAL A CA  1 
ATOM 1069 C C   . VAL A 1 159 ? 81.944  70.298  76.386  1.00 52.37  ? 159 VAL A C   1 
ATOM 1070 O O   . VAL A 1 159 ? 82.634  71.296  76.153  1.00 52.37  ? 159 VAL A O   1 
ATOM 1071 C CB  . VAL A 1 159 ? 82.304  68.473  78.105  1.00 52.37  ? 159 VAL A CB  1 
ATOM 1072 C CG1 . VAL A 1 159 ? 82.780  67.044  78.288  1.00 52.37  ? 159 VAL A CG1 1 
ATOM 1073 C CG2 . VAL A 1 159 ? 82.969  69.381  79.112  1.00 52.37  ? 159 VAL A CG2 1 
ATOM 1074 N N   . ASP A 1 160 ? 80.612  70.323  76.383  1.00 54.15  ? 160 ASP A N   1 
ATOM 1075 C CA  . ASP A 1 160 ? 79.864  71.494  75.939  1.00 54.15  ? 160 ASP A CA  1 
ATOM 1076 C C   . ASP A 1 160 ? 80.083  72.693  76.857  1.00 54.15  ? 160 ASP A C   1 
ATOM 1077 O O   . ASP A 1 160 ? 80.365  72.545  78.048  1.00 54.15  ? 160 ASP A O   1 
ATOM 1078 C CB  . ASP A 1 160 ? 78.373  71.165  75.865  1.00 54.15  ? 160 ASP A CB  1 
ATOM 1079 C CG  . ASP A 1 160 ? 77.588  72.194  75.076  1.00 54.15  ? 160 ASP A CG  1 
ATOM 1080 O OD1 . ASP A 1 160 ? 77.862  72.352  73.868  1.00 54.15  ? 160 ASP A OD1 1 
ATOM 1081 O OD2 . ASP A 1 160 ? 76.699  72.845  75.663  1.00 54.15  ? 160 ASP A OD2 1 
ATOM 1082 N N   . MET A 1 161 ? 79.952  73.890  76.275  1.00 50.83  ? 161 MET A N   1 
ATOM 1083 C CA  . MET A 1 161 ? 80.136  75.141  77.007  1.00 50.83  ? 161 MET A CA  1 
ATOM 1084 C C   . MET A 1 161 ? 79.167  75.281  78.173  1.00 50.83  ? 161 MET A C   1 
ATOM 1085 O O   . MET A 1 161 ? 79.574  75.629  79.288  1.00 50.83  ? 161 MET A O   1 
ATOM 1086 C CB  . MET A 1 161 ? 79.970  76.315  76.041  1.00 50.83  ? 161 MET A CB  1 
ATOM 1087 C CG  . MET A 1 161 ? 80.272  77.685  76.619  1.00 50.83  ? 161 MET A CG  1 
ATOM 1088 S SD  . MET A 1 161 ? 81.984  77.947  77.084  1.00 50.83  ? 161 MET A SD  1 
ATOM 1089 C CE  . MET A 1 161 ? 81.782  79.250  78.294  1.00 50.83  ? 161 MET A CE  1 
ATOM 1090 N N   . HIS A 1 162 ? 77.879  75.028  77.930  1.00 52.69  ? 162 HIS A N   1 
ATOM 1091 C CA  . HIS A 1 162 ? 76.871  75.212  78.969  1.00 52.69  ? 162 HIS A CA  1 
ATOM 1092 C C   . HIS A 1 162 ? 77.083  74.231  80.117  1.00 52.69  ? 162 HIS A C   1 
ATOM 1093 O O   . HIS A 1 162 ? 77.031  74.610  81.296  1.00 52.69  ? 162 HIS A O   1 
ATOM 1094 C CB  . HIS A 1 162 ? 75.475  75.048  78.369  1.00 52.69  ? 162 HIS A CB  1 
ATOM 1095 C CG  . HIS A 1 162 ? 75.094  76.136  77.413  1.00 52.69  ? 162 HIS A CG  1 
ATOM 1096 N ND1 . HIS A 1 162 ? 75.366  77.466  77.650  1.00 52.69  ? 162 HIS A ND1 1 
ATOM 1097 C CD2 . HIS A 1 162 ? 74.460  76.090  76.218  1.00 52.69  ? 162 HIS A CD2 1 
ATOM 1098 C CE1 . HIS A 1 162 ? 74.918  78.192  76.642  1.00 52.69  ? 162 HIS A CE1 1 
ATOM 1099 N NE2 . HIS A 1 162 ? 74.364  77.381  75.759  1.00 52.69  ? 162 HIS A NE2 1 
ATOM 1100 N N   . ILE A 1 163 ? 77.349  72.968  79.782  1.00 49.38  ? 163 ILE A N   1 
ATOM 1101 C CA  . ILE A 1 163 ? 77.606  71.953  80.798  1.00 49.38  ? 163 ILE A CA  1 
ATOM 1102 C C   . ILE A 1 163 ? 78.889  72.274  81.556  1.00 49.38  ? 163 ILE A C   1 
ATOM 1103 O O   . ILE A 1 163 ? 78.965  72.093  82.774  1.00 49.38  ? 163 ILE A O   1 
ATOM 1104 C CB  . ILE A 1 163 ? 77.657  70.556  80.151  1.00 49.38  ? 163 ILE A CB  1 
ATOM 1105 C CG1 . ILE A 1 163 ? 76.336  70.252  79.444  1.00 49.38  ? 163 ILE A CG1 1 
ATOM 1106 C CG2 . ILE A 1 163 ? 77.936  69.485  81.192  1.00 49.38  ? 163 ILE A CG2 1 
ATOM 1107 C CD1 . ILE A 1 163 ? 75.140  70.240  80.366  1.00 49.38  ? 163 ILE A CD1 1 
ATOM 1108 N N   . SER A 1 164 ? 79.913  72.761  80.846  1.00 46.18  ? 164 SER A N   1 
ATOM 1109 C CA  . SER A 1 164 ? 81.164  73.134  81.503  1.00 46.18  ? 164 SER A CA  1 
ATOM 1110 C C   . SER A 1 164 ? 80.949  74.250  82.513  1.00 46.18  ? 164 SER A C   1 
ATOM 1111 O O   . SER A 1 164 ? 81.452  74.178  83.640  1.00 46.18  ? 164 SER A O   1 
ATOM 1112 C CB  . SER A 1 164 ? 82.199  73.564  80.468  1.00 46.18  ? 164 SER A CB  1 
ATOM 1113 O OG  . SER A 1 164 ? 82.541  72.491  79.620  1.00 46.18  ? 164 SER A OG  1 
ATOM 1114 N N   . VAL A 1 165 ? 80.191  75.282  82.130  1.00 44.87  ? 165 VAL A N   1 
ATOM 1115 C CA  . VAL A 1 165 ? 79.908  76.383  83.045  1.00 44.87  ? 165 VAL A CA  1 
ATOM 1116 C C   . VAL A 1 165 ? 79.127  75.884  84.254  1.00 44.87  ? 165 VAL A C   1 
ATOM 1117 O O   . VAL A 1 165 ? 79.456  76.221  85.401  1.00 44.87  ? 165 VAL A O   1 
ATOM 1118 C CB  . VAL A 1 165 ? 79.159  77.510  82.310  1.00 44.87  ? 165 VAL A CB  1 
ATOM 1119 C CG1 . VAL A 1 165 ? 78.569  78.503  83.300  1.00 44.87  ? 165 VAL A CG1 1 
ATOM 1120 C CG2 . VAL A 1 165 ? 80.087  78.215  81.350  1.00 44.87  ? 165 VAL A CG2 1 
ATOM 1121 N N   . ILE A 1 166 ? 78.110  75.047  84.023  1.00 46.74  ? 166 ILE A N   1 
ATOM 1122 C CA  . ILE A 1 166 ? 77.275  74.556  85.120  1.00 46.74  ? 166 ILE A CA  1 
ATOM 1123 C C   . ILE A 1 166 ? 78.097  73.717  86.094  1.00 46.74  ? 166 ILE A C   1 
ATOM 1124 O O   . ILE A 1 166 ? 78.038  73.921  87.311  1.00 46.74  ? 166 ILE A O   1 
ATOM 1125 C CB  . ILE A 1 166 ? 76.072  73.765  84.573  1.00 46.74  ? 166 ILE A CB  1 
ATOM 1126 C CG1 . ILE A 1 166 ? 75.079  74.706  83.891  1.00 46.74  ? 166 ILE A CG1 1 
ATOM 1127 C CG2 . ILE A 1 166 ? 75.381  72.995  85.689  1.00 46.74  ? 166 ILE A CG2 1 
ATOM 1128 C CD1 . ILE A 1 166 ? 73.817  74.023  83.414  1.00 46.74  ? 166 ILE A CD1 1 
ATOM 1129 N N   . ILE A 1 167 ? 78.898  72.783  85.574  1.00 46.78  ? 167 ILE A N   1 
ATOM 1130 C CA  . ILE A 1 167 ? 79.653  71.882  86.445  1.00 46.78  ? 167 ILE A CA  1 
ATOM 1131 C C   . ILE A 1 167 ? 80.766  72.631  87.172  1.00 46.78  ? 167 ILE A C   1 
ATOM 1132 O O   . ILE A 1 167 ? 81.016  72.388  88.356  1.00 46.78  ? 167 ILE A O   1 
ATOM 1133 C CB  . ILE A 1 167 ? 80.194  70.677  85.652  1.00 46.78  ? 167 ILE A CB  1 
ATOM 1134 C CG1 . ILE A 1 167 ? 79.043  69.896  85.016  1.00 46.78  ? 167 ILE A CG1 1 
ATOM 1135 C CG2 . ILE A 1 167 ? 80.998  69.750  86.547  1.00 46.78  ? 167 ILE A CG2 1 
ATOM 1136 C CD1 . ILE A 1 167 ? 78.068  69.327  86.020  1.00 46.78  ? 167 ILE A CD1 1 
ATOM 1137 N N   . SER A 1 168 ? 81.453  73.549  86.483  1.00 45.08  ? 168 SER A N   1 
ATOM 1138 C CA  . SER A 1 168 ? 82.508  74.314  87.144  1.00 45.08  ? 168 SER A CA  1 
ATOM 1139 C C   . SER A 1 168 ? 81.942  75.194  88.254  1.00 45.08  ? 168 SER A C   1 
ATOM 1140 O O   . SER A 1 168 ? 82.502  75.251  89.359  1.00 45.08  ? 168 SER A O   1 
ATOM 1141 C CB  . SER A 1 168 ? 83.264  75.156  86.118  1.00 45.08  ? 168 SER A CB  1 
ATOM 1142 O OG  . SER A 1 168 ? 82.533  76.320  85.780  1.00 45.08  ? 168 SER A OG  1 
ATOM 1143 N N   . ALA A 1 169 ? 80.816  75.866  87.989  1.00 46.51  ? 169 ALA A N   1 
ATOM 1144 C CA  . ALA A 1 169 ? 80.172  76.657  89.028  1.00 46.51  ? 169 ALA A CA  1 
ATOM 1145 C C   . ALA A 1 169 ? 79.662  75.783  90.164  1.00 46.51  ? 169 ALA A C   1 
ATOM 1146 O O   . ALA A 1 169 ? 79.694  76.200  91.323  1.00 46.51  ? 169 ALA A O   1 
ATOM 1147 C CB  . ALA A 1 169 ? 79.028  77.475  88.435  1.00 46.51  ? 169 ALA A CB  1 
ATOM 1148 N N   . LEU A 1 170 ? 79.208  74.565  89.858  1.00 53.73  ? 170 LEU A N   1 
ATOM 1149 C CA  . LEU A 1 170 ? 78.730  73.662  90.900  1.00 53.73  ? 170 LEU A CA  1 
ATOM 1150 C C   . LEU A 1 170 ? 79.870  73.170  91.786  1.00 53.73  ? 170 LEU A C   1 
ATOM 1151 O O   . LEU A 1 170 ? 79.708  73.072  93.007  1.00 53.73  ? 170 LEU A O   1 
ATOM 1152 C CB  . LEU A 1 170 ? 77.999  72.479  90.264  1.00 53.73  ? 170 LEU A CB  1 
ATOM 1153 C CG  . LEU A 1 170 ? 77.368  71.464  91.214  1.00 53.73  ? 170 LEU A CG  1 
ATOM 1154 C CD1 . LEU A 1 170 ? 76.290  72.141  92.043  1.00 53.73  ? 170 LEU A CD1 1 
ATOM 1155 C CD2 . LEU A 1 170 ? 76.799  70.282  90.448  1.00 53.73  ? 170 LEU A CD2 1 
ATOM 1156 N N   . ILE A 1 171 ? 81.027  72.860  91.194  1.00 53.41  ? 171 ILE A N   1 
ATOM 1157 C CA  . ILE A 1 171 ? 82.191  72.462  91.986  1.00 53.41  ? 171 ILE A CA  1 
ATOM 1158 C C   . ILE A 1 171 ? 82.661  73.618  92.858  1.00 53.41  ? 171 ILE A C   1 
ATOM 1159 O O   . ILE A 1 171 ? 83.013  73.430  94.029  1.00 53.41  ? 171 ILE A O   1 
ATOM 1160 C CB  . ILE A 1 171 ? 83.322  71.937  91.079  1.00 53.41  ? 171 ILE A CB  1 
ATOM 1161 C CG1 . ILE A 1 171 ? 82.853  70.730  90.266  1.00 53.41  ? 171 ILE A CG1 1 
ATOM 1162 C CG2 . ILE A 1 171 ? 84.547  71.567  91.897  1.00 53.41  ? 171 ILE A CG2 1 
ATOM 1163 C CD1 . ILE A 1 171 ? 82.431  69.551  91.108  1.00 53.41  ? 171 ILE A CD1 1 
ATOM 1164 N N   . ALA A 1 172 ? 82.675  74.835  92.303  1.00 57.66  ? 172 ALA A N   1 
ATOM 1165 C CA  . ALA A 1 172 ? 83.034  76.000  93.107  1.00 57.66  ? 172 ALA A CA  1 
ATOM 1166 C C   . ALA A 1 172 ? 82.037  76.221  94.243  1.00 57.66  ? 172 ALA A C   1 
ATOM 1167 O O   . ALA A 1 172 ? 82.429  76.547  95.372  1.00 57.66  ? 172 ALA A O   1 
ATOM 1168 C CB  . ALA A 1 172 ? 83.126  77.239  92.219  1.00 57.66  ? 172 ALA A CB  1 
ATOM 1169 N N   . THR A 1 173 ? 80.746  76.027  93.964  1.00 61.31  ? 173 THR A N   1 
ATOM 1170 C CA  . THR A 1 173 ? 79.710  76.198  94.977  1.00 61.31  ? 173 THR A CA  1 
ATOM 1171 C C   . THR A 1 173 ? 79.837  75.156  96.083  1.00 61.31  ? 173 THR A C   1 
ATOM 1172 O O   . THR A 1 173 ? 79.628  75.461  97.260  1.00 61.31  ? 173 THR A O   1 
ATOM 1173 C CB  . THR A 1 173 ? 78.329  76.128  94.320  1.00 61.31  ? 173 THR A CB  1 
ATOM 1174 O OG1 . THR A 1 173 ? 78.234  77.131  93.301  1.00 61.31  ? 173 THR A OG1 1 
ATOM 1175 C CG2 . THR A 1 173 ? 77.223  76.358  95.342  1.00 61.31  ? 173 THR A CG2 1 
ATOM 1176 N N   . LEU A 1 174 ? 80.179  73.916  95.725  1.00 65.05  ? 174 LEU A N   1 
ATOM 1177 C CA  . LEU A 1 174 ? 80.358  72.881  96.741  1.00 65.05  ? 174 LEU A CA  1 
ATOM 1178 C C   . LEU A 1 174 ? 81.636  73.091  97.543  1.00 65.05  ? 174 LEU A C   1 
ATOM 1179 O O   . LEU A 1 174 ? 81.673  72.792  98.742  1.00 65.05  ? 174 LEU A O   1 
ATOM 1180 C CB  . LEU A 1 174 ? 80.349  71.493  96.101  1.00 65.05  ? 174 LEU A CB  1 
ATOM 1181 C CG  . LEU A 1 174 ? 79.013  70.746  96.123  1.00 65.05  ? 174 LEU A CG  1 
ATOM 1182 C CD1 . LEU A 1 174 ? 77.988  71.394  95.213  1.00 65.05  ? 174 LEU A CD1 1 
ATOM 1183 C CD2 . LEU A 1 174 ? 79.220  69.288  95.748  1.00 65.05  ? 174 LEU A CD2 1 
ATOM 1184 N N   . TYR A 1 175 ? 82.701  73.584  96.903  1.00 68.62  ? 175 TYR A N   1 
ATOM 1185 C CA  . TYR A 1 175 ? 83.922  73.884  97.644  1.00 68.62  ? 175 TYR A CA  1 
ATOM 1186 C C   . TYR A 1 175 ? 83.689  75.019  98.632  1.00 68.62  ? 175 TYR A C   1 
ATOM 1187 O O   . TYR A 1 175 ? 84.203  74.991  99.756  1.00 68.62  ? 175 TYR A O   1 
ATOM 1188 C CB  . TYR A 1 175 ? 85.061  74.224  96.679  1.00 68.62  ? 175 TYR A CB  1 
ATOM 1189 C CG  . TYR A 1 175 ? 86.335  74.707  97.348  1.00 68.62  ? 175 TYR A CG  1 
ATOM 1190 C CD1 . TYR A 1 175 ? 86.564  76.061  97.579  1.00 68.62  ? 175 TYR A CD1 1 
ATOM 1191 C CD2 . TYR A 1 175 ? 87.309  73.804  97.753  1.00 68.62  ? 175 TYR A CD2 1 
ATOM 1192 C CE1 . TYR A 1 175 ? 87.724  76.497  98.192  1.00 68.62  ? 175 TYR A CE1 1 
ATOM 1193 C CE2 . TYR A 1 175 ? 88.473  74.231  98.365  1.00 68.62  ? 175 TYR A CE2 1 
ATOM 1194 C CZ  . TYR A 1 175 ? 88.674  75.578  98.583  1.00 68.62  ? 175 TYR A CZ  1 
ATOM 1195 O OH  . TYR A 1 175 ? 89.831  76.007  99.193  1.00 68.62  ? 175 TYR A OH  1 
ATOM 1196 N N   . THR A 1 176 ? 82.931  76.037  98.222  1.00 68.86  ? 176 THR A N   1 
ATOM 1197 C CA  . THR A 1 176 ? 82.564  77.108  99.142  1.00 68.86  ? 176 THR A CA  1 
ATOM 1198 C C   . THR A 1 176 ? 81.633  76.593  100.236 1.00 68.86  ? 176 THR A C   1 
ATOM 1199 O O   . THR A 1 176 ? 81.751  76.979  101.405 1.00 68.86  ? 176 THR A O   1 
ATOM 1200 C CB  . THR A 1 176 ? 81.912  78.251  98.361  1.00 68.86  ? 176 THR A CB  1 
ATOM 1201 O OG1 . THR A 1 176 ? 82.839  78.752  97.389  1.00 68.86  ? 176 THR A OG1 1 
ATOM 1202 C CG2 . THR A 1 176 ? 81.512  79.383  99.288  1.00 68.86  ? 176 THR A CG2 1 
ATOM 1203 N N   . LEU A 1 177 ? 80.718  75.694  99.871  1.00 72.65  ? 177 LEU A N   1 
ATOM 1204 C CA  . LEU A 1 177 ? 79.671  75.247  100.783 1.00 72.65  ? 177 LEU A CA  1 
ATOM 1205 C C   . LEU A 1 177 ? 80.222  74.323  101.862 1.00 72.65  ? 177 LEU A C   1 
ATOM 1206 O O   . LEU A 1 177 ? 79.873  74.459  103.041 1.00 72.65  ? 177 LEU A O   1 
ATOM 1207 C CB  . LEU A 1 177 ? 78.573  74.547  99.983  1.00 72.65  ? 177 LEU A CB  1 
ATOM 1208 C CG  . LEU A 1 177 ? 77.401  73.910  100.724 1.00 72.65  ? 177 LEU A CG  1 
ATOM 1209 C CD1 . LEU A 1 177 ? 76.616  74.979  101.443 1.00 72.65  ? 177 LEU A CD1 1 
ATOM 1210 C CD2 . LEU A 1 177 ? 76.511  73.141  99.759  1.00 72.65  ? 177 LEU A CD2 1 
ATOM 1211 N N   . VAL A 1 178 ? 81.083  73.373  101.479 1.00 74.74  ? 178 VAL A N   1 
ATOM 1212 C CA  . VAL A 1 178 ? 81.617  72.402  102.428 1.00 74.74  ? 178 VAL A CA  1 
ATOM 1213 C C   . VAL A 1 178 ? 82.883  72.896  103.115 1.00 74.74  ? 178 VAL A C   1 
ATOM 1214 O O   . VAL A 1 178 ? 83.050  72.674  104.323 1.00 74.74  ? 178 VAL A O   1 
ATOM 1215 C CB  . VAL A 1 178 ? 81.879  71.056  101.718 1.00 74.74  ? 178 VAL A CB  1 
ATOM 1216 C CG1 . VAL A 1 178 ? 82.359  70.001  102.705 1.00 74.74  ? 178 VAL A CG1 1 
ATOM 1217 C CG2 . VAL A 1 178 ? 80.623  70.584  101.004 1.00 74.74  ? 178 VAL A CG2 1 
ATOM 1218 N N   . GLY A 1 179 ? 83.765  73.581  102.396 1.00 72.78  ? 179 GLY A N   1 
ATOM 1219 C CA  . GLY A 1 179 ? 84.993  74.088  102.981 1.00 72.78  ? 179 GLY A CA  1 
ATOM 1220 C C   . GLY A 1 179 ? 86.231  73.689  102.204 1.00 72.78  ? 179 GLY A C   1 
ATOM 1221 O O   . GLY A 1 179 ? 87.016  74.542  101.790 1.00 72.78  ? 179 GLY A O   1 
ATOM 1222 N N   . SER A 1 183 ? 93.205  75.518  106.893 1.00 83.70  ? 183 SER A N   1 
ATOM 1223 C CA  . SER A 1 183 ? 94.444  75.567  106.126 1.00 83.70  ? 183 SER A CA  1 
ATOM 1224 C C   . SER A 1 183 ? 94.249  76.345  104.829 1.00 83.70  ? 183 SER A C   1 
ATOM 1225 O O   . SER A 1 183 ? 93.557  77.365  104.816 1.00 83.70  ? 183 SER A O   1 
ATOM 1226 C CB  . SER A 1 183 ? 94.945  74.153  105.826 1.00 83.70  ? 183 SER A CB  1 
ATOM 1227 O OG  . SER A 1 183 ? 95.471  73.542  106.991 1.00 83.70  ? 183 SER A OG  1 
ATOM 1228 N N   . VAL A 1 184 ? 94.869  75.845  103.753 1.00 82.60  ? 184 VAL A N   1 
ATOM 1229 C CA  . VAL A 1 184 ? 94.778  76.407  102.406 1.00 82.60  ? 184 VAL A CA  1 
ATOM 1230 C C   . VAL A 1 184 ? 95.277  77.851  102.459 1.00 82.60  ? 184 VAL A C   1 
ATOM 1231 O O   . VAL A 1 184 ? 94.502  78.806  102.332 1.00 82.60  ? 184 VAL A O   1 
ATOM 1232 C CB  . VAL A 1 184 ? 93.341  76.277  101.848 1.00 82.60  ? 184 VAL A CB  1 
ATOM 1233 C CG1 . VAL A 1 184 ? 93.230  76.773  100.408 1.00 82.60  ? 184 VAL A CG1 1 
ATOM 1234 C CG2 . VAL A 1 184 ? 92.865  74.834  101.945 1.00 82.60  ? 184 VAL A CG2 1 
ATOM 1235 N N   . ALA A 1 185 ? 96.572  78.017  102.721 1.00 78.09  ? 185 ALA A N   1 
ATOM 1236 C CA  . ALA A 1 185 ? 97.175  79.336  102.864 1.00 78.09  ? 185 ALA A CA  1 
ATOM 1237 C C   . ALA A 1 185 ? 98.177  79.601  101.747 1.00 78.09  ? 185 ALA A C   1 
ATOM 1238 O O   . ALA A 1 185 ? 98.710  78.666  101.142 1.00 78.09  ? 185 ALA A O   1 
ATOM 1239 C CB  . ALA A 1 185 ? 97.864  79.468  104.222 1.00 78.09  ? 185 ALA A CB  1 
ATOM 1240 N N   . TYR A 1 186 ? 98.419  80.890  101.478 1.00 71.82  ? 186 TYR A N   1 
ATOM 1241 C CA  . TYR A 1 186 ? 99.366  81.362  100.463 1.00 71.82  ? 186 TYR A CA  1 
ATOM 1242 C C   . TYR A 1 186 ? 99.013  80.869  99.065  1.00 71.82  ? 186 TYR A C   1 
ATOM 1243 O O   . TYR A 1 186 ? 99.893  80.707  98.218  1.00 71.82  ? 186 TYR A O   1 
ATOM 1244 C CB  . TYR A 1 186 ? 100.808 80.968  100.804 1.00 71.82  ? 186 TYR A CB  1 
ATOM 1245 C CG  . TYR A 1 186 ? 101.548 81.988  101.634 1.00 71.82  ? 186 TYR A CG  1 
ATOM 1246 C CD1 . TYR A 1 186 ? 101.602 83.319  101.245 1.00 71.82  ? 186 TYR A CD1 1 
ATOM 1247 C CD2 . TYR A 1 186 ? 102.201 81.618  102.802 1.00 71.82  ? 186 TYR A CD2 1 
ATOM 1248 C CE1 . TYR A 1 186 ? 102.277 84.254  102.001 1.00 71.82  ? 186 TYR A CE1 1 
ATOM 1249 C CE2 . TYR A 1 186 ? 102.881 82.546  103.564 1.00 71.82  ? 186 TYR A CE2 1 
ATOM 1250 C CZ  . TYR A 1 186 ? 102.917 83.862  103.158 1.00 71.82  ? 186 TYR A CZ  1 
ATOM 1251 O OH  . TYR A 1 186 ? 103.593 84.793  103.913 1.00 71.82  ? 186 TYR A OH  1 
ATOM 1252 N N   . THR A 1 187 ? 97.727  80.629  98.807  1.00 63.14  ? 187 THR A N   1 
ATOM 1253 C CA  . THR A 1 187 ? 97.333  80.052  97.527  1.00 63.14  ? 187 THR A CA  1 
ATOM 1254 C C   . THR A 1 187 ? 97.341  81.088  96.412  1.00 63.14  ? 187 THR A C   1 
ATOM 1255 O O   . THR A 1 187 ? 97.566  80.740  95.250  1.00 63.14  ? 187 THR A O   1 
ATOM 1256 C CB  . THR A 1 187 ? 95.958  79.400  97.640  1.00 63.14  ? 187 THR A CB  1 
ATOM 1257 O OG1 . THR A 1 187 ? 94.990  80.380  98.037  1.00 63.14  ? 187 THR A OG1 1 
ATOM 1258 C CG2 . THR A 1 187 ? 95.998  78.280  98.655  1.00 63.14  ? 187 THR A CG2 1 
ATOM 1259 N N   . ASP A 1 188 ? 97.097  82.361  96.744  1.00 58.65  ? 188 ASP A N   1 
ATOM 1260 C CA  . ASP A 1 188 ? 96.981  83.400  95.721  1.00 58.65  ? 188 ASP A CA  1 
ATOM 1261 C C   . ASP A 1 188 ? 98.282  83.564  94.945  1.00 58.65  ? 188 ASP A C   1 
ATOM 1262 O O   . ASP A 1 188 ? 98.274  83.712  93.716  1.00 58.65  ? 188 ASP A O   1 
ATOM 1263 C CB  . ASP A 1 188 ? 96.577  84.726  96.364  1.00 58.65  ? 188 ASP A CB  1 
ATOM 1264 C CG  . ASP A 1 188 ? 95.161  84.708  96.897  1.00 58.65  ? 188 ASP A CG  1 
ATOM 1265 O OD1 . ASP A 1 188 ? 94.322  83.971  96.338  1.00 58.65  ? 188 ASP A OD1 1 
ATOM 1266 O OD2 . ASP A 1 188 ? 94.886  85.431  97.877  1.00 58.65  ? 188 ASP A OD2 1 
ATOM 1267 N N   . VAL A 1 189 ? 99.413  83.534  95.652  1.00 52.91  ? 189 VAL A N   1 
ATOM 1268 C CA  . VAL A 1 189 ? 100.716 83.601  94.998  1.00 52.91  ? 189 VAL A CA  1 
ATOM 1269 C C   . VAL A 1 189 ? 100.915 82.395  94.089  1.00 52.91  ? 189 VAL A C   1 
ATOM 1270 O O   . VAL A 1 189 ? 101.465 82.512  92.989  1.00 52.91  ? 189 VAL A O   1 
ATOM 1271 C CB  . VAL A 1 189 ? 101.831 83.716  96.056  1.00 52.91  ? 189 VAL A CB  1 
ATOM 1272 C CG1 . VAL A 1 189 ? 103.209 83.601  95.421  1.00 52.91  ? 189 VAL A CG1 1 
ATOM 1273 C CG2 . VAL A 1 189 ? 101.700 85.024  96.818  1.00 52.91  ? 189 VAL A CG2 1 
ATOM 1274 N N   . VAL A 1 190 ? 100.445 81.222  94.522  1.00 50.37  ? 190 VAL A N   1 
ATOM 1275 C CA  . VAL A 1 190 ? 100.596 80.010  93.721  1.00 50.37  ? 190 VAL A CA  1 
ATOM 1276 C C   . VAL A 1 190 ? 99.769  80.095  92.442  1.00 50.37  ? 190 VAL A C   1 
ATOM 1277 O O   . VAL A 1 190 ? 100.247 79.740  91.360  1.00 50.37  ? 190 VAL A O   1 
ATOM 1278 C CB  . VAL A 1 190 ? 100.226 78.773  94.558  1.00 50.37  ? 190 VAL A CB  1 
ATOM 1279 C CG1 . VAL A 1 190 ? 100.401 77.504  93.742  1.00 50.37  ? 190 VAL A CG1 1 
ATOM 1280 C CG2 . VAL A 1 190 ? 101.068 78.722  95.816  1.00 50.37  ? 190 VAL A CG2 1 
ATOM 1281 N N   . GLN A 1 191 ? 98.521  80.565  92.541  1.00 48.54  ? 191 GLN A N   1 
ATOM 1282 C CA  . GLN A 1 191 ? 97.690  80.723  91.349  1.00 48.54  ? 191 GLN A CA  1 
ATOM 1283 C C   . GLN A 1 191 ? 98.266  81.766  90.402  1.00 48.54  ? 191 GLN A C   1 
ATOM 1284 O O   . GLN A 1 191 ? 98.260  81.572  89.181  1.00 48.54  ? 191 GLN A O   1 
ATOM 1285 C CB  . GLN A 1 191 ? 96.257  81.100  91.729  1.00 48.54  ? 191 GLN A CB  1 
ATOM 1286 C CG  . GLN A 1 191 ? 95.656  80.298  92.860  1.00 48.54  ? 191 GLN A CG  1 
ATOM 1287 C CD  . GLN A 1 191 ? 94.412  80.947  93.431  1.00 48.54  ? 191 GLN A CD  1 
ATOM 1288 O OE1 . GLN A 1 191 ? 94.080  82.083  93.097  1.00 48.54  ? 191 GLN A OE1 1 
ATOM 1289 N NE2 . GLN A 1 191 ? 93.711  80.222  94.295  1.00 48.54  ? 191 GLN A NE2 1 
ATOM 1290 N N   . LEU A 1 192 ? 98.759  82.885  90.942  1.00 42.28  ? 192 LEU A N   1 
ATOM 1291 C CA  . LEU A 1 192 ? 99.347  83.914  90.091  1.00 42.28  ? 192 LEU A CA  1 
ATOM 1292 C C   . LEU A 1 192 ? 100.611 83.416  89.402  1.00 42.28  ? 192 LEU A C   1 
ATOM 1293 O O   . LEU A 1 192 ? 100.821 83.692  88.217  1.00 42.28  ? 192 LEU A O   1 
ATOM 1294 C CB  . LEU A 1 192 ? 99.641  85.168  90.911  1.00 42.28  ? 192 LEU A CB  1 
ATOM 1295 C CG  . LEU A 1 192 ? 99.946  86.434  90.112  1.00 42.28  ? 192 LEU A CG  1 
ATOM 1296 C CD1 . LEU A 1 192 ? 98.827  86.724  89.127  1.00 42.28  ? 192 LEU A CD1 1 
ATOM 1297 C CD2 . LEU A 1 192 ? 100.153 87.609  91.048  1.00 42.28  ? 192 LEU A CD2 1 
ATOM 1298 N N   . PHE A 1 193 ? 101.451 82.670  90.123  1.00 42.34  ? 193 PHE A N   1 
ATOM 1299 C CA  . PHE A 1 193 ? 102.644 82.088  89.520  1.00 42.34  ? 193 PHE A CA  1 
ATOM 1300 C C   . PHE A 1 193 ? 102.284 81.055  88.461  1.00 42.34  ? 193 PHE A C   1 
ATOM 1301 O O   . PHE A 1 193 ? 102.940 80.979  87.418  1.00 42.34  ? 193 PHE A O   1 
ATOM 1302 C CB  . PHE A 1 193 ? 103.521 81.463  90.604  1.00 42.34  ? 193 PHE A CB  1 
ATOM 1303 C CG  . PHE A 1 193 ? 104.942 81.241  90.181  1.00 42.34  ? 193 PHE A CG  1 
ATOM 1304 C CD1 . PHE A 1 193 ? 105.761 82.313  89.871  1.00 42.34  ? 193 PHE A CD1 1 
ATOM 1305 C CD2 . PHE A 1 193 ? 105.459 79.960  90.091  1.00 42.34  ? 193 PHE A CD2 1 
ATOM 1306 C CE1 . PHE A 1 193 ? 107.070 82.111  89.480  1.00 42.34  ? 193 PHE A CE1 1 
ATOM 1307 C CE2 . PHE A 1 193 ? 106.767 79.751  89.701  1.00 42.34  ? 193 PHE A CE2 1 
ATOM 1308 C CZ  . PHE A 1 193 ? 107.573 80.828  89.396  1.00 42.34  ? 193 PHE A CZ  1 
ATOM 1309 N N   . CYS A 1 194 ? 101.247 80.252  88.711  1.00 42.99  ? 194 CYS A N   1 
ATOM 1310 C CA  . CYS A 1 194 ? 100.810 79.264  87.730  1.00 42.99  ? 194 CYS A CA  1 
ATOM 1311 C C   . CYS A 1 194 ? 100.294 79.936  86.464  1.00 42.99  ? 194 CYS A C   1 
ATOM 1312 O O   . CYS A 1 194 ? 100.621 79.511  85.352  1.00 42.99  ? 194 CYS A O   1 
ATOM 1313 C CB  . CYS A 1 194 ? 99.736  78.363  88.339  1.00 42.99  ? 194 CYS A CB  1 
ATOM 1314 S SG  . CYS A 1 194 ? 100.372 77.073  89.428  1.00 42.99  ? 194 CYS A SG  1 
ATOM 1315 N N   . ILE A 1 195 ? 99.499  80.999  86.617  1.00 39.01  ? 195 ILE A N   1 
ATOM 1316 C CA  . ILE A 1 195 ? 99.004  81.743  85.461  1.00 39.01  ? 195 ILE A CA  1 
ATOM 1317 C C   . ILE A 1 195 ? 100.161 82.375  84.697  1.00 39.01  ? 195 ILE A C   1 
ATOM 1318 O O   . ILE A 1 195 ? 100.228 82.294  83.465  1.00 39.01  ? 195 ILE A O   1 
ATOM 1319 C CB  . ILE A 1 195 ? 97.974  82.800  85.902  1.00 39.01  ? 195 ILE A CB  1 
ATOM 1320 C CG1 . ILE A 1 195 ? 96.687  82.133  86.382  1.00 39.01  ? 195 ILE A CG1 1 
ATOM 1321 C CG2 . ILE A 1 195 ? 97.661  83.760  84.768  1.00 39.01  ? 195 ILE A CG2 1 
ATOM 1322 C CD1 . ILE A 1 195 ? 95.694  83.096  86.991  1.00 39.01  ? 195 ILE A CD1 1 
ATOM 1323 N N   . PHE A 1 196 ? 101.104 82.986  85.422  1.00 38.55  ? 196 PHE A N   1 
ATOM 1324 C CA  . PHE A 1 196 ? 102.244 83.645  84.791  1.00 38.55  ? 196 PHE A CA  1 
ATOM 1325 C C   . PHE A 1 196 ? 103.094 82.649  84.010  1.00 38.55  ? 196 PHE A C   1 
ATOM 1326 O O   . PHE A 1 196 ? 103.446 82.895  82.851  1.00 38.55  ? 196 PHE A O   1 
ATOM 1327 C CB  . PHE A 1 196 ? 103.065 84.363  85.870  1.00 38.55  ? 196 PHE A CB  1 
ATOM 1328 C CG  . PHE A 1 196 ? 104.370 84.950  85.387  1.00 38.55  ? 196 PHE A CG  1 
ATOM 1329 C CD1 . PHE A 1 196 ? 105.548 84.216  85.435  1.00 38.55  ? 196 PHE A CD1 1 
ATOM 1330 C CD2 . PHE A 1 196 ? 104.422 86.252  84.920  1.00 38.55  ? 196 PHE A CD2 1 
ATOM 1331 C CE1 . PHE A 1 196 ? 106.741 84.763  85.003  1.00 38.55  ? 196 PHE A CE1 1 
ATOM 1332 C CE2 . PHE A 1 196 ? 105.615 86.805  84.492  1.00 38.55  ? 196 PHE A CE2 1 
ATOM 1333 C CZ  . PHE A 1 196 ? 106.774 86.059  84.532  1.00 38.55  ? 196 PHE A CZ  1 
ATOM 1334 N N   . VAL A 1 197 ? 103.407 81.503  84.618  1.00 39.65  ? 197 VAL A N   1 
ATOM 1335 C CA  . VAL A 1 197 ? 104.253 80.512  83.958  1.00 39.65  ? 197 VAL A CA  1 
ATOM 1336 C C   . VAL A 1 197 ? 103.520 79.875  82.782  1.00 39.65  ? 197 VAL A C   1 
ATOM 1337 O O   . VAL A 1 197 ? 104.093 79.705  81.701  1.00 39.65  ? 197 VAL A O   1 
ATOM 1338 C CB  . VAL A 1 197 ? 104.736 79.457  84.971  1.00 39.65  ? 197 VAL A CB  1 
ATOM 1339 C CG1 . VAL A 1 197 ? 105.405 78.292  84.262  1.00 39.65  ? 197 VAL A CG1 1 
ATOM 1340 C CG2 . VAL A 1 197 ? 105.707 80.084  85.956  1.00 39.65  ? 197 VAL A CG2 1 
ATOM 1341 N N   . GLY A 1 198 ? 102.241 79.533  82.963  1.00 37.71  ? 198 GLY A N   1 
ATOM 1342 C CA  . GLY A 1 198 ? 101.491 78.913  81.884  1.00 37.71  ? 198 GLY A CA  1 
ATOM 1343 C C   . GLY A 1 198 ? 101.290 79.834  80.697  1.00 37.71  ? 198 GLY A C   1 
ATOM 1344 O O   . GLY A 1 198 ? 101.269 79.384  79.549  1.00 37.71  ? 198 GLY A O   1 
ATOM 1345 N N   . LEU A 1 199 ? 101.127 81.134  80.954  1.00 36.13  ? 199 LEU A N   1 
ATOM 1346 C CA  . LEU A 1 199 ? 100.995 82.082  79.856  1.00 36.13  ? 199 LEU A CA  1 
ATOM 1347 C C   . LEU A 1 199 ? 102.336 82.352  79.182  1.00 36.13  ? 199 LEU A C   1 
ATOM 1348 O O   . LEU A 1 199 ? 102.419 82.386  77.950  1.00 36.13  ? 199 LEU A O   1 
ATOM 1349 C CB  . LEU A 1 199 ? 100.373 83.386  80.358  1.00 36.13  ? 199 LEU A CB  1 
ATOM 1350 C CG  . LEU A 1 199 ? 98.881  83.349  80.704  1.00 36.13  ? 199 LEU A CG  1 
ATOM 1351 C CD1 . LEU A 1 199 ? 98.325  84.753  80.876  1.00 36.13  ? 199 LEU A CD1 1 
ATOM 1352 C CD2 . LEU A 1 199 ? 98.085  82.567  79.674  1.00 36.13  ? 199 LEU A CD2 1 
ATOM 1353 N N   . TRP A 1 200 ? 103.400 82.537  79.968  1.00 35.89  ? 200 TRP A N   1 
ATOM 1354 C CA  . TRP A 1 200 ? 104.682 82.929  79.398  1.00 35.89  ? 200 TRP A CA  1 
ATOM 1355 C C   . TRP A 1 200 ? 105.489 81.749  78.879  1.00 35.89  ? 200 TRP A C   1 
ATOM 1356 O O   . TRP A 1 200 ? 106.553 81.960  78.290  1.00 35.89  ? 200 TRP A O   1 
ATOM 1357 C CB  . TRP A 1 200 ? 105.502 83.701  80.431  1.00 35.89  ? 200 TRP A CB  1 
ATOM 1358 C CG  . TRP A 1 200 ? 105.263 85.178  80.393  1.00 35.89  ? 200 TRP A CG  1 
ATOM 1359 C CD1 . TRP A 1 200 ? 104.742 85.943  81.389  1.00 35.89  ? 200 TRP A CD1 1 
ATOM 1360 C CD2 . TRP A 1 200 ? 105.534 86.068  79.302  1.00 35.89  ? 200 TRP A CD2 1 
ATOM 1361 N NE1 . TRP A 1 200 ? 104.672 87.254  80.993  1.00 35.89  ? 200 TRP A NE1 1 
ATOM 1362 C CE2 . TRP A 1 200 ? 105.152 87.358  79.715  1.00 35.89  ? 200 TRP A CE2 1 
ATOM 1363 C CE3 . TRP A 1 200 ? 106.064 85.901  78.019  1.00 35.89  ? 200 TRP A CE3 1 
ATOM 1364 C CZ2 . TRP A 1 200 ? 105.280 88.474  78.892  1.00 35.89  ? 200 TRP A CZ2 1 
ATOM 1365 C CZ3 . TRP A 1 200 ? 106.190 87.009  77.204  1.00 35.89  ? 200 TRP A CZ3 1 
ATOM 1366 C CH2 . TRP A 1 200 ? 105.800 88.279  77.643  1.00 35.89  ? 200 TRP A CH2 1 
ATOM 1367 N N   . ILE A 1 201 ? 105.026 80.516  79.099  1.00 40.85  ? 201 ILE A N   1 
ATOM 1368 C CA  . ILE A 1 201 ? 105.613 79.366  78.421  1.00 40.85  ? 201 ILE A CA  1 
ATOM 1369 C C   . ILE A 1 201 ? 104.813 78.989  77.185  1.00 40.85  ? 201 ILE A C   1 
ATOM 1370 O O   . ILE A 1 201 ? 105.282 78.175  76.375  1.00 40.85  ? 201 ILE A O   1 
ATOM 1371 C CB  . ILE A 1 201 ? 105.736 78.167  79.386  1.00 40.85  ? 201 ILE A CB  1 
ATOM 1372 C CG1 . ILE A 1 201 ? 106.919 77.278  78.995  1.00 40.85  ? 201 ILE A CG1 1 
ATOM 1373 C CG2 . ILE A 1 201 ? 104.450 77.352  79.418  1.00 40.85  ? 201 ILE A CG2 1 
ATOM 1374 C CD1 . ILE A 1 201 ? 108.259 77.977  79.065  1.00 40.85  ? 201 ILE A CD1 1 
ATOM 1375 N N   . SER A 1 202 ? 103.627 79.569  77.004  1.00 40.53  ? 202 SER A N   1 
ATOM 1376 C CA  . SER A 1 202 ? 102.805 79.335  75.826  1.00 40.53  ? 202 SER A CA  1 
ATOM 1377 C C   . SER A 1 202 ? 102.921 80.437  74.785  1.00 40.53  ? 202 SER A C   1 
ATOM 1378 O O   . SER A 1 202 ? 102.740 80.161  73.595  1.00 40.53  ? 202 SER A O   1 
ATOM 1379 C CB  . SER A 1 202 ? 101.335 79.181  76.232  1.00 40.53  ? 202 SER A CB  1 
ATOM 1380 O OG  . SER A 1 202 ? 101.145 78.034  77.041  1.00 40.53  ? 202 SER A OG  1 
ATOM 1381 N N   . VAL A 1 203 ? 103.209 81.677  75.204  1.00 38.45  ? 203 VAL A N   1 
ATOM 1382 C CA  . VAL A 1 203 ? 103.422 82.761  74.234  1.00 38.45  ? 203 VAL A CA  1 
ATOM 1383 C C   . VAL A 1 203 ? 104.574 82.485  73.267  1.00 38.45  ? 203 VAL A C   1 
ATOM 1384 O O   . VAL A 1 203 ? 104.402 82.727  72.062  1.00 38.45  ? 203 VAL A O   1 
ATOM 1385 C CB  . VAL A 1 203 ? 103.561 84.111  74.962  1.00 38.45  ? 203 VAL A CB  1 
ATOM 1386 C CG1 . VAL A 1 203 ? 103.897 85.215  73.977  1.00 38.45  ? 203 VAL A CG1 1 
ATOM 1387 C CG2 . VAL A 1 203 ? 102.260 84.475  75.642  1.00 38.45  ? 203 VAL A CG2 1 
ATOM 1388 N N   . PRO A 1 204 ? 105.758 82.012  73.703  1.00 38.83  ? 204 PRO A N   1 
ATOM 1389 C CA  . PRO A 1 204 ? 106.787 81.671  72.699  1.00 38.83  ? 204 PRO A CA  1 
ATOM 1390 C C   . PRO A 1 204 ? 106.368 80.578  71.729  1.00 38.83  ? 204 PRO A C   1 
ATOM 1391 O O   . PRO A 1 204 ? 106.748 80.625  70.553  1.00 38.83  ? 204 PRO A O   1 
ATOM 1392 C CB  . PRO A 1 204 ? 107.983 81.238  73.556  1.00 38.83  ? 204 PRO A CB  1 
ATOM 1393 C CG  . PRO A 1 204 ? 107.783 81.914  74.842  1.00 38.83  ? 204 PRO A CG  1 
ATOM 1394 C CD  . PRO A 1 204 ? 106.311 81.896  75.066  1.00 38.83  ? 204 PRO A CD  1 
ATOM 1395 N N   . PHE A 1 205 ? 105.594 79.592  72.185  1.00 41.45  ? 205 PHE A N   1 
ATOM 1396 C CA  . PHE A 1 205 ? 105.126 78.549  71.277  1.00 41.45  ? 205 PHE A CA  1 
ATOM 1397 C C   . PHE A 1 205 ? 103.992 79.051  70.391  1.00 41.45  ? 205 PHE A C   1 
ATOM 1398 O O   . PHE A 1 205 ? 103.890 78.652  69.225  1.00 41.45  ? 205 PHE A O   1 
ATOM 1399 C CB  . PHE A 1 205 ? 104.690 77.318  72.069  1.00 41.45  ? 205 PHE A CB  1 
ATOM 1400 C CG  . PHE A 1 205 ? 105.834 76.489  72.576  1.00 41.45  ? 205 PHE A CG  1 
ATOM 1401 C CD1 . PHE A 1 205 ? 106.405 75.513  71.779  1.00 41.45  ? 205 PHE A CD1 1 
ATOM 1402 C CD2 . PHE A 1 205 ? 106.343 76.690  73.846  1.00 41.45  ? 205 PHE A CD2 1 
ATOM 1403 C CE1 . PHE A 1 205 ? 107.458 74.750  72.243  1.00 41.45  ? 205 PHE A CE1 1 
ATOM 1404 C CE2 . PHE A 1 205 ? 107.397 75.932  74.314  1.00 41.45  ? 205 PHE A CE2 1 
ATOM 1405 C CZ  . PHE A 1 205 ? 107.953 74.961  73.513  1.00 41.45  ? 205 PHE A CZ  1 
ATOM 1406 N N   . ALA A 1 206 ? 103.123 79.910  70.929  1.00 39.78  ? 206 ALA A N   1 
ATOM 1407 C CA  . ALA A 1 206 ? 102.028 80.458  70.133  1.00 39.78  ? 206 ALA A CA  1 
ATOM 1408 C C   . ALA A 1 206 ? 102.552 81.375  69.035  1.00 39.78  ? 206 ALA A C   1 
ATOM 1409 O O   . ALA A 1 206 ? 102.070 81.337  67.897  1.00 39.78  ? 206 ALA A O   1 
ATOM 1410 C CB  . ALA A 1 206 ? 101.044 81.203  71.034  1.00 39.78  ? 206 ALA A CB  1 
ATOM 1411 N N   . LEU A 1 207 ? 103.543 82.207  69.361  1.00 38.58  ? 207 LEU A N   1 
ATOM 1412 C CA  . LEU A 1 207 ? 104.119 83.114  68.373  1.00 38.58  ? 207 LEU A CA  1 
ATOM 1413 C C   . LEU A 1 207 ? 104.853 82.350  67.279  1.00 38.58  ? 207 LEU A C   1 
ATOM 1414 O O   . LEU A 1 207 ? 104.897 82.792  66.126  1.00 38.58  ? 207 LEU A O   1 
ATOM 1415 C CB  . LEU A 1 207 ? 105.061 84.101  69.059  1.00 38.58  ? 207 LEU A CB  1 
ATOM 1416 C CG  . LEU A 1 207 ? 104.475 85.461  69.436  1.00 38.58  ? 207 LEU A CG  1 
ATOM 1417 C CD1 . LEU A 1 207 ? 105.433 86.223  70.331  1.00 38.58  ? 207 LEU A CD1 1 
ATOM 1418 C CD2 . LEU A 1 207 ? 104.157 86.263  68.189  1.00 38.58  ? 207 LEU A CD2 1 
ATOM 1419 N N   . SER A 1 208 ? 105.440 81.205  67.624  1.00 42.39  ? 208 SER A N   1 
ATOM 1420 C CA  . SER A 1 208 ? 106.190 80.404  66.665  1.00 42.39  ? 208 SER A CA  1 
ATOM 1421 C C   . SER A 1 208 ? 105.308 79.485  65.829  1.00 42.39  ? 208 SER A C   1 
ATOM 1422 O O   . SER A 1 208 ? 105.837 78.759  64.981  1.00 42.39  ? 208 SER A O   1 
ATOM 1423 C CB  . SER A 1 208 ? 107.248 79.575  67.394  1.00 42.39  ? 208 SER A CB  1 
ATOM 1424 O OG  . SER A 1 208 ? 108.126 80.408  68.129  1.00 42.39  ? 208 SER A OG  1 
ATOM 1425 N N   . HIS A 1 209 ? 103.998 79.483  66.058  1.00 44.91  ? 209 HIS A N   1 
ATOM 1426 C CA  . HIS A 1 209 ? 103.105 78.647  65.270  1.00 44.91  ? 209 HIS A CA  1 
ATOM 1427 C C   . HIS A 1 209 ? 103.081 79.128  63.821  1.00 44.91  ? 209 HIS A C   1 
ATOM 1428 O O   . HIS A 1 209 ? 103.136 80.338  63.569  1.00 44.91  ? 209 HIS A O   1 
ATOM 1429 C CB  . HIS A 1 209 ? 101.693 78.668  65.860  1.00 44.91  ? 209 HIS A CB  1 
ATOM 1430 C CG  . HIS A 1 209 ? 100.851 77.496  65.459  1.00 44.91  ? 209 HIS A CG  1 
ATOM 1431 N ND1 . HIS A 1 209 ? 100.209 77.421  64.242  1.00 44.91  ? 209 HIS A ND1 1 
ATOM 1432 C CD2 . HIS A 1 209 ? 100.552 76.348  66.112  1.00 44.91  ? 209 HIS A CD2 1 
ATOM 1433 C CE1 . HIS A 1 209 ? 99.548  76.280  64.164  1.00 44.91  ? 209 HIS A CE1 1 
ATOM 1434 N NE2 . HIS A 1 209 ? 99.739  75.611  65.286  1.00 44.91  ? 209 HIS A NE2 1 
ATOM 1435 N N   . PRO A 1 210 ? 103.036 78.212  62.848  1.00 47.25  ? 210 PRO A N   1 
ATOM 1436 C CA  . PRO A 1 210 ? 103.021 78.638  61.436  1.00 47.25  ? 210 PRO A CA  1 
ATOM 1437 C C   . PRO A 1 210 ? 101.820 79.486  61.051  1.00 47.25  ? 210 PRO A C   1 
ATOM 1438 O O   . PRO A 1 210 ? 101.939 80.353  60.176  1.00 47.25  ? 210 PRO A O   1 
ATOM 1439 C CB  . PRO A 1 210 ? 103.035 77.304  60.677  1.00 47.25  ? 210 PRO A CB  1 
ATOM 1440 C CG  . PRO A 1 210 ? 103.674 76.346  61.616  1.00 47.25  ? 210 PRO A CG  1 
ATOM 1441 C CD  . PRO A 1 210 ? 103.223 76.758  62.985  1.00 47.25  ? 210 PRO A CD  1 
ATOM 1442 N N   . ALA A 1 211 ? 100.661 79.253  61.672  1.00 44.99  ? 211 ALA A N   1 
ATOM 1443 C CA  . ALA A 1 211 ? 99.454  79.981  61.291  1.00 44.99  ? 211 ALA A CA  1 
ATOM 1444 C C   . ALA A 1 211 ? 99.545  81.454  61.668  1.00 44.99  ? 211 ALA A C   1 
ATOM 1445 O O   . ALA A 1 211 ? 98.984  82.314  60.980  1.00 44.99  ? 211 ALA A O   1 
ATOM 1446 C CB  . ALA A 1 211 ? 98.228  79.339  61.939  1.00 44.99  ? 211 ALA A CB  1 
ATOM 1447 N N   . VAL A 1 212 ? 100.247 81.764  62.756  1.00 43.33  ? 212 VAL A N   1 
ATOM 1448 C CA  . VAL A 1 212 ? 100.314 83.137  63.239  1.00 43.33  ? 212 VAL A CA  1 
ATOM 1449 C C   . VAL A 1 212 ? 101.267 83.946  62.371  1.00 43.33  ? 212 VAL A C   1 
ATOM 1450 O O   . VAL A 1 212 ? 102.433 83.575  62.182  1.00 43.33  ? 212 VAL A O   1 
ATOM 1451 C CB  . VAL A 1 212 ? 100.744 83.167  64.711  1.00 43.33  ? 212 VAL A CB  1 
ATOM 1452 C CG1 . VAL A 1 212 ? 100.512 84.545  65.299  1.00 43.33  ? 212 VAL A CG1 1 
ATOM 1453 C CG2 . VAL A 1 212 ? 99.991  82.114  65.492  1.00 43.33  ? 212 VAL A CG2 1 
ATOM 1454 N N   . ALA A 1 213 ? 100.773 85.059  61.838  1.00 48.50  ? 213 ALA A N   1 
ATOM 1455 C CA  . ALA A 1 213 ? 101.611 86.013  61.135  1.00 48.50  ? 213 ALA A CA  1 
ATOM 1456 C C   . ALA A 1 213 ? 102.334 86.912  62.135  1.00 48.50  ? 213 ALA A C   1 
ATOM 1457 O O   . ALA A 1 213 ? 102.182 86.783  63.353  1.00 48.50  ? 213 ALA A O   1 
ATOM 1458 C CB  . ALA A 1 213 ? 100.778 86.848  60.166  1.00 48.50  ? 213 ALA A CB  1 
ATOM 1459 N N   . ASP A 1 214 ? 103.145 87.825  61.604  1.00 49.98  ? 214 ASP A N   1 
ATOM 1460 C CA  . ASP A 1 214 ? 103.862 88.778  62.442  1.00 49.98  ? 214 ASP A CA  1 
ATOM 1461 C C   . ASP A 1 214 ? 102.877 89.689  63.164  1.00 49.98  ? 214 ASP A C   1 
ATOM 1462 O O   . ASP A 1 214 ? 101.993 90.285  62.543  1.00 49.98  ? 214 ASP A O   1 
ATOM 1463 C CB  . ASP A 1 214 ? 104.826 89.602  61.584  1.00 49.98  ? 214 ASP A CB  1 
ATOM 1464 C CG  . ASP A 1 214 ? 105.698 90.542  62.404  1.00 49.98  ? 214 ASP A CG  1 
ATOM 1465 O OD1 . ASP A 1 214 ? 105.730 90.423  63.647  1.00 49.98  ? 214 ASP A OD1 1 
ATOM 1466 O OD2 . ASP A 1 214 ? 106.359 91.409  61.796  1.00 49.98  ? 214 ASP A OD2 1 
ATOM 1467 N N   . ILE A 1 215 ? 103.033 89.792  64.485  1.00 43.03  ? 215 ILE A N   1 
ATOM 1468 C CA  . ILE A 1 215 ? 102.139 90.640  65.265  1.00 43.03  ? 215 ILE A CA  1 
ATOM 1469 C C   . ILE A 1 215 ? 102.568 92.100  65.239  1.00 43.03  ? 215 ILE A C   1 
ATOM 1470 O O   . ILE A 1 215 ? 101.763 92.978  65.574  1.00 43.03  ? 215 ILE A O   1 
ATOM 1471 C CB  . ILE A 1 215 ? 102.031 90.142  66.716  1.00 43.03  ? 215 ILE A CB  1 
ATOM 1472 C CG1 . ILE A 1 215 ? 103.335 90.392  67.469  1.00 43.03  ? 215 ILE A CG1 1 
ATOM 1473 C CG2 . ILE A 1 215 ? 101.663 88.670  66.749  1.00 43.03  ? 215 ILE A CG2 1 
ATOM 1474 C CD1 . ILE A 1 215 ? 103.162 90.441  68.956  1.00 43.03  ? 215 ILE A CD1 1 
ATOM 1475 N N   . GLY A 1 216 ? 103.816 92.388  64.868  1.00 46.00  ? 216 GLY A N   1 
ATOM 1476 C CA  . GLY A 1 216 ? 104.205 93.770  64.645  1.00 46.00  ? 216 GLY A CA  1 
ATOM 1477 C C   . GLY A 1 216 ? 103.541 94.364  63.418  1.00 46.00  ? 216 GLY A C   1 
ATOM 1478 O O   . GLY A 1 216 ? 103.122 95.523  63.426  1.00 46.00  ? 216 GLY A O   1 
ATOM 1479 N N   . PHE A 1 217 ? 103.440 93.577  62.346  1.00 49.74  ? 217 PHE A N   1 
ATOM 1480 C CA  . PHE A 1 217 ? 102.811 94.060  61.121  1.00 49.74  ? 217 PHE A CA  1 
ATOM 1481 C C   . PHE A 1 217 ? 101.298 94.129  61.276  1.00 49.74  ? 217 PHE A C   1 
ATOM 1482 O O   . PHE A 1 217 ? 100.655 95.059  60.775  1.00 49.74  ? 217 PHE A O   1 
ATOM 1483 C CB  . PHE A 1 217 ? 103.206 93.160  59.947  1.00 49.74  ? 217 PHE A CB  1 
ATOM 1484 C CG  . PHE A 1 217 ? 102.635 93.590  58.622  1.00 49.74  ? 217 PHE A CG  1 
ATOM 1485 C CD1 . PHE A 1 217 ? 101.417 93.099  58.175  1.00 49.74  ? 217 PHE A CD1 1 
ATOM 1486 C CD2 . PHE A 1 217 ? 103.318 94.492  57.825  1.00 49.74  ? 217 PHE A CD2 1 
ATOM 1487 C CE1 . PHE A 1 217 ? 100.897 93.497  56.959  1.00 49.74  ? 217 PHE A CE1 1 
ATOM 1488 C CE2 . PHE A 1 217 ? 102.802 94.893  56.608  1.00 49.74  ? 217 PHE A CE2 1 
ATOM 1489 C CZ  . PHE A 1 217 ? 101.591 94.395  56.176  1.00 49.74  ? 217 PHE A CZ  1 
ATOM 1490 N N   . THR A 1 218 ? 100.710 93.144  61.958  1.00 46.19  ? 218 THR A N   1 
ATOM 1491 C CA  . THR A 1 218 ? 99.264  93.108  62.152  1.00 46.19  ? 218 THR A CA  1 
ATOM 1492 C C   . THR A 1 218 ? 98.781  94.243  63.050  1.00 46.19  ? 218 THR A C   1 
ATOM 1493 O O   . THR A 1 218 ? 97.616  94.643  62.959  1.00 46.19  ? 218 THR A O   1 
ATOM 1494 C CB  . THR A 1 218 ? 98.860  91.747  62.730  1.00 46.19  ? 218 THR A CB  1 
ATOM 1495 O OG1 . THR A 1 218 ? 99.462  90.706  61.952  1.00 46.19  ? 218 THR A OG1 1 
ATOM 1496 C CG2 . THR A 1 218 ? 97.353  91.548  62.676  1.00 46.19  ? 218 THR A CG2 1 
ATOM 1497 N N   . ALA A 1 219 ? 99.663  94.788  63.891  1.00 44.46  ? 219 ALA A N   1 
ATOM 1498 C CA  . ALA A 1 219 ? 99.278  95.864  64.797  1.00 44.46  ? 219 ALA A CA  1 
ATOM 1499 C C   . ALA A 1 219 ? 98.874  97.131  64.054  1.00 44.46  ? 219 ALA A C   1 
ATOM 1500 O O   . ALA A 1 219 ? 97.980  97.855  64.503  1.00 44.46  ? 219 ALA A O   1 
ATOM 1501 C CB  . ALA A 1 219 ? 100.426 96.164  65.760  1.00 44.46  ? 219 ALA A CB  1 
ATOM 1502 N N   . VAL A 1 220 ? 99.508  97.415  62.918  1.00 49.90  ? 220 VAL A N   1 
ATOM 1503 C CA  . VAL A 1 220 ? 99.272  98.672  62.217  1.00 49.90  ? 220 VAL A CA  1 
ATOM 1504 C C   . VAL A 1 220 ? 98.623  98.427  60.860  1.00 49.90  ? 220 VAL A C   1 
ATOM 1505 O O   . VAL A 1 220 ? 98.044  99.343  60.267  1.00 49.90  ? 220 VAL A O   1 
ATOM 1506 C CB  . VAL A 1 220 ? 100.582 99.466  62.065  1.00 49.90  ? 220 VAL A CB  1 
ATOM 1507 C CG1 . VAL A 1 220 ? 101.115 99.865  63.430  1.00 49.90  ? 220 VAL A CG1 1 
ATOM 1508 C CG2 . VAL A 1 220 ? 101.613 98.648  61.310  1.00 49.90  ? 220 VAL A CG2 1 
ATOM 1509 N N   . HIS A 1 221 ? 98.709  97.198  60.359  1.00 51.40  ? 221 HIS A N   1 
ATOM 1510 C CA  . HIS A 1 221 ? 98.159  96.848  59.059  1.00 51.40  ? 221 HIS A CA  1 
ATOM 1511 C C   . HIS A 1 221 ? 97.226  95.652  59.190  1.00 51.40  ? 221 HIS A C   1 
ATOM 1512 O O   . HIS A 1 221 ? 97.366  94.833  60.101  1.00 51.40  ? 221 HIS A O   1 
ATOM 1513 C CB  . HIS A 1 221 ? 99.270  96.540  58.048  1.00 51.40  ? 221 HIS A CB  1 
ATOM 1514 C CG  . HIS A 1 221 ? 100.200 97.687  57.806  1.00 51.40  ? 221 HIS A CG  1 
ATOM 1515 N ND1 . HIS A 1 221 ? 101.551 97.618  58.068  1.00 51.40  ? 221 HIS A ND1 1 
ATOM 1516 C CD2 . HIS A 1 221 ? 99.972  98.935  57.332  1.00 51.40  ? 221 HIS A CD2 1 
ATOM 1517 C CE1 . HIS A 1 221 ? 102.116 98.773  57.763  1.00 51.40  ? 221 HIS A CE1 1 
ATOM 1518 N NE2 . HIS A 1 221 ? 101.180 99.589  57.314  1.00 51.40  ? 221 HIS A NE2 1 
ATOM 1519 N N   . ALA A 1 222 ? 96.272  95.557  58.269  1.00 53.87  ? 222 ALA A N   1 
ATOM 1520 C CA  . ALA A 1 222 ? 95.234  94.536  58.318  1.00 53.87  ? 222 ALA A CA  1 
ATOM 1521 C C   . ALA A 1 222 ? 95.595  93.369  57.409  1.00 53.87  ? 222 ALA A C   1 
ATOM 1522 O O   . ALA A 1 222 ? 95.848  93.560  56.215  1.00 53.87  ? 222 ALA A O   1 
ATOM 1523 C CB  . ALA A 1 222 ? 93.882  95.121  57.909  1.00 53.87  ? 222 ALA A CB  1 
ATOM 1524 N N   . LYS A 1 223 ? 95.622  92.161  57.979  1.00 51.45  ? 223 LYS A N   1 
ATOM 1525 C CA  . LYS A 1 223 ? 95.846  90.945  57.201  1.00 51.45  ? 223 LYS A CA  1 
ATOM 1526 C C   . LYS A 1 223 ? 94.620  90.041  57.243  1.00 51.45  ? 223 LYS A C   1 
ATOM 1527 O O   . LYS A 1 223 ? 94.104  89.671  56.186  1.00 51.45  ? 223 LYS A O   1 
ATOM 1528 C CB  . LYS A 1 223 ? 97.094  90.216  57.702  1.00 51.45  ? 223 LYS A CB  1 
ATOM 1529 C CG  . LYS A 1 223 ? 97.512  89.040  56.830  1.00 51.45  ? 223 LYS A CG  1 
ATOM 1530 C CD  . LYS A 1 223 ? 98.892  88.521  57.205  1.00 51.45  ? 223 LYS A CD  1 
ATOM 1531 C CE  . LYS A 1 223 ? 99.933  89.630  57.202  1.00 51.45  ? 223 LYS A CE  1 
ATOM 1532 N NZ  . LYS A 1 223 ? 99.931  90.407  55.931  1.00 51.45  ? 223 LYS A NZ  1 
ATOM 1533 N N   . TYR A 1 224 ? 94.136  89.671  58.428  1.00 49.91  ? 224 TYR A N   1 
ATOM 1534 C CA  . TYR A 1 224 ? 92.959  88.823  58.567  1.00 49.91  ? 224 TYR A CA  1 
ATOM 1535 C C   . TYR A 1 224 ? 91.748  89.583  59.085  1.00 49.91  ? 224 TYR A C   1 
ATOM 1536 O O   . TYR A 1 224 ? 90.616  89.281  58.694  1.00 49.91  ? 224 TYR A O   1 
ATOM 1537 C CB  . TYR A 1 224 ? 93.258  87.647  59.502  1.00 49.91  ? 224 TYR A CB  1 
ATOM 1538 C CG  . TYR A 1 224 ? 94.406  86.784  59.036  1.00 49.91  ? 224 TYR A CG  1 
ATOM 1539 C CD1 . TYR A 1 224 ? 94.257  85.917  57.963  1.00 49.91  ? 224 TYR A CD1 1 
ATOM 1540 C CD2 . TYR A 1 224 ? 95.638  86.835  59.672  1.00 49.91  ? 224 TYR A CD2 1 
ATOM 1541 C CE1 . TYR A 1 224 ? 95.305  85.130  57.533  1.00 49.91  ? 224 TYR A CE1 1 
ATOM 1542 C CE2 . TYR A 1 224 ? 96.691  86.050  59.250  1.00 49.91  ? 224 TYR A CE2 1 
ATOM 1543 C CZ  . TYR A 1 224 ? 96.520  85.201  58.180  1.00 49.91  ? 224 TYR A CZ  1 
ATOM 1544 O OH  . TYR A 1 224 ? 97.567  84.416  57.757  1.00 49.91  ? 224 TYR A OH  1 
ATOM 1545 N N   . GLN A 1 225 ? 91.965  90.562  59.955  1.00 47.91  ? 225 GLN A N   1 
ATOM 1546 C CA  . GLN A 1 225 ? 90.903  91.421  60.456  1.00 47.91  ? 225 GLN A CA  1 
ATOM 1547 C C   . GLN A 1 225 ? 91.481  92.822  60.613  1.00 47.91  ? 225 GLN A C   1 
ATOM 1548 O O   . GLN A 1 225 ? 92.591  93.104  60.153  1.00 47.91  ? 225 GLN A O   1 
ATOM 1549 C CB  . GLN A 1 225 ? 90.326  90.862  61.764  1.00 47.91  ? 225 GLN A CB  1 
ATOM 1550 C CG  . GLN A 1 225 ? 91.272  90.921  62.953  1.00 47.91  ? 225 GLN A CG  1 
ATOM 1551 C CD  . GLN A 1 225 ? 90.674  90.307  64.200  1.00 47.91  ? 225 GLN A CD  1 
ATOM 1552 O OE1 . GLN A 1 225 ? 89.989  89.288  64.136  1.00 47.91  ? 225 GLN A OE1 1 
ATOM 1553 N NE2 . GLN A 1 225 ? 90.908  90.939  65.340  1.00 47.91  ? 225 GLN A NE2 1 
ATOM 1554 N N   . LYS A 1 226 ? 90.726  93.705  61.257  1.00 50.44  ? 226 LYS A N   1 
ATOM 1555 C CA  . LYS A 1 226 ? 91.208  95.058  61.485  1.00 50.44  ? 226 LYS A CA  1 
ATOM 1556 C C   . LYS A 1 226 ? 92.394  95.033  62.448  1.00 50.44  ? 226 LYS A C   1 
ATOM 1557 O O   . LYS A 1 226 ? 92.494  94.123  63.280  1.00 50.44  ? 226 LYS A O   1 
ATOM 1558 C CB  . LYS A 1 226 ? 90.086  95.941  62.037  1.00 50.44  ? 226 LYS A CB  1 
ATOM 1559 C CG  . LYS A 1 226 ? 89.324  96.699  60.961  1.00 50.44  ? 226 LYS A CG  1 
ATOM 1560 C CD  . LYS A 1 226 ? 87.840  96.787  61.273  1.00 50.44  ? 226 LYS A CD  1 
ATOM 1561 C CE  . LYS A 1 226 ? 87.597  97.414  62.633  1.00 50.44  ? 226 LYS A CE  1 
ATOM 1562 N NZ  . LYS A 1 226 ? 86.273  98.089  62.706  1.00 50.44  ? 226 LYS A NZ  1 
ATOM 1563 N N   . PRO A 1 227 ? 93.333  95.999  62.338  1.00 44.06  ? 227 PRO A N   1 
ATOM 1564 C CA  . PRO A 1 227 ? 94.519  96.002  63.211  1.00 44.06  ? 227 PRO A CA  1 
ATOM 1565 C C   . PRO A 1 227 ? 94.194  96.007  64.697  1.00 44.06  ? 227 PRO A C   1 
ATOM 1566 O O   . PRO A 1 227 ? 93.287  96.716  65.142  1.00 44.06  ? 227 PRO A O   1 
ATOM 1567 C CB  . PRO A 1 227 ? 95.246  97.289  62.804  1.00 44.06  ? 227 PRO A CB  1 
ATOM 1568 C CG  . PRO A 1 227 ? 94.820  97.547  61.410  1.00 44.06  ? 227 PRO A CG  1 
ATOM 1569 C CD  . PRO A 1 227 ? 93.444  96.976  61.241  1.00 44.06  ? 227 PRO A CD  1 
ATOM 1570 N N   . TRP A 1 228 ? 94.938  95.217  65.475  1.00 38.22  ? 228 TRP A N   1 
ATOM 1571 C CA  . TRP A 1 228 ? 94.579  94.993  66.868  1.00 38.22  ? 228 TRP A CA  1 
ATOM 1572 C C   . TRP A 1 228 ? 95.008  96.126  67.789  1.00 38.22  ? 228 TRP A C   1 
ATOM 1573 O O   . TRP A 1 228 ? 94.645  96.102  68.970  1.00 38.22  ? 228 TRP A O   1 
ATOM 1574 C CB  . TRP A 1 228 ? 95.154  93.659  67.356  1.00 38.22  ? 228 TRP A CB  1 
ATOM 1575 C CG  . TRP A 1 228 ? 96.642  93.514  67.248  1.00 38.22  ? 228 TRP A CG  1 
ATOM 1576 C CD1 . TRP A 1 228 ? 97.335  92.963  66.212  1.00 38.22  ? 228 TRP A CD1 1 
ATOM 1577 C CD2 . TRP A 1 228 ? 97.615  93.884  68.231  1.00 38.22  ? 228 TRP A CD2 1 
ATOM 1578 N NE1 . TRP A 1 228 ? 98.681  92.986  66.479  1.00 38.22  ? 228 TRP A NE1 1 
ATOM 1579 C CE2 . TRP A 1 228 ? 98.879  93.548  67.712  1.00 38.22  ? 228 TRP A CE2 1 
ATOM 1580 C CE3 . TRP A 1 228 ? 97.542  94.477  69.494  1.00 38.22  ? 228 TRP A CE3 1 
ATOM 1581 C CZ2 . TRP A 1 228 ? 100.058 93.781  68.413  1.00 38.22  ? 228 TRP A CZ2 1 
ATOM 1582 C CZ3 . TRP A 1 228 ? 98.712  94.710  70.186  1.00 38.22  ? 228 TRP A CZ3 1 
ATOM 1583 C CH2 . TRP A 1 228 ? 99.953  94.364  69.645  1.00 38.22  ? 228 TRP A CH2 1 
ATOM 1584 N N   . LEU A 1 229 ? 95.769  97.106  67.297  1.00 41.49  ? 229 LEU A N   1 
ATOM 1585 C CA  . LEU A 1 229 ? 95.937  98.336  68.064  1.00 41.49  ? 229 LEU A CA  1 
ATOM 1586 C C   . LEU A 1 229 ? 94.635  99.121  68.116  1.00 41.49  ? 229 LEU A C   1 
ATOM 1587 O O   . LEU A 1 229 ? 94.308  99.726  69.143  1.00 41.49  ? 229 LEU A O   1 
ATOM 1588 C CB  . LEU A 1 229 ? 97.053  99.199  67.476  1.00 41.49  ? 229 LEU A CB  1 
ATOM 1589 C CG  . LEU A 1 229 ? 98.498  98.722  67.596  1.00 41.49  ? 229 LEU A CG  1 
ATOM 1590 C CD1 . LEU A 1 229 ? 99.424  99.651  66.829  1.00 41.49  ? 229 LEU A CD1 1 
ATOM 1591 C CD2 . LEU A 1 229 ? 98.912  98.651  69.048  1.00 41.49  ? 229 LEU A CD2 1 
ATOM 1592 N N   . GLY A 1 230 ? 93.879  99.116  67.022  1.00 45.72  ? 230 GLY A N   1 
ATOM 1593 C CA  . GLY A 1 230 ? 92.637  99.852  66.950  1.00 45.72  ? 230 GLY A CA  1 
ATOM 1594 C C   . GLY A 1 230 ? 92.852  101.319 66.657  1.00 45.72  ? 230 GLY A C   1 
ATOM 1595 O O   . GLY A 1 230 ? 93.973  101.812 66.496  1.00 45.72  ? 230 GLY A O   1 
ATOM 1596 N N   . THR A 1 231 ? 91.735  102.036 66.579  1.00 51.43  ? 231 THR A N   1 
ATOM 1597 C CA  . THR A 1 231 ? 91.754  103.474 66.375  1.00 51.43  ? 231 THR A CA  1 
ATOM 1598 C C   . THR A 1 231 ? 90.585  104.100 67.119  1.00 51.43  ? 231 THR A C   1 
ATOM 1599 O O   . THR A 1 231 ? 89.563  103.454 67.364  1.00 51.43  ? 231 THR A O   1 
ATOM 1600 C CB  . THR A 1 231 ? 91.700  103.840 64.881  1.00 51.43  ? 231 THR A CB  1 
ATOM 1601 O OG1 . THR A 1 231 ? 91.849  105.257 64.726  1.00 51.43  ? 231 THR A OG1 1 
ATOM 1602 C CG2 . THR A 1 231 ? 90.387  103.390 64.252  1.00 51.43  ? 231 THR A CG2 1 
ATOM 1603 N N   . VAL A 1 232 ? 90.756  105.363 67.495  1.00 53.46  ? 232 VAL A N   1 
ATOM 1604 C CA  . VAL A 1 232 ? 89.719  106.141 68.162  1.00 53.46  ? 232 VAL A CA  1 
ATOM 1605 C C   . VAL A 1 232 ? 89.346  107.295 67.244  1.00 53.46  ? 232 VAL A C   1 
ATOM 1606 O O   . VAL A 1 232 ? 90.199  108.118 66.890  1.00 53.46  ? 232 VAL A O   1 
ATOM 1607 C CB  . VAL A 1 232 ? 90.185  106.653 69.533  1.00 53.46  ? 232 VAL A CB  1 
ATOM 1608 C CG1 . VAL A 1 232 ? 89.033  107.309 70.271  1.00 53.46  ? 232 VAL A CG1 1 
ATOM 1609 C CG2 . VAL A 1 232 ? 90.769  105.516 70.350  1.00 53.46  ? 232 VAL A CG2 1 
ATOM 1610 N N   . ASP A 1 233 ? 88.076  107.353 66.855  1.00 63.39  ? 233 ASP A N   1 
ATOM 1611 C CA  . ASP A 1 233 ? 87.603  108.429 66.003  1.00 63.39  ? 233 ASP A CA  1 
ATOM 1612 C C   . ASP A 1 233 ? 87.485  109.722 66.802  1.00 63.39  ? 233 ASP A C   1 
ATOM 1613 O O   . ASP A 1 233 ? 87.409  109.715 68.033  1.00 63.39  ? 233 ASP A O   1 
ATOM 1614 C CB  . ASP A 1 233 ? 86.257  108.068 65.377  1.00 63.39  ? 233 ASP A CB  1 
ATOM 1615 C CG  . ASP A 1 233 ? 86.136  108.545 63.946  1.00 63.39  ? 233 ASP A CG  1 
ATOM 1616 O OD1 . ASP A 1 233 ? 87.021  109.301 63.495  1.00 63.39  ? 233 ASP A OD1 1 
ATOM 1617 O OD2 . ASP A 1 233 ? 85.157  108.163 63.271  1.00 63.39  ? 233 ASP A OD2 1 
ATOM 1618 N N   . SER A 1 234 ? 87.477  110.844 66.077  1.00 63.22  ? 234 SER A N   1 
ATOM 1619 C CA  . SER A 1 234 ? 87.418  112.157 66.717  1.00 63.22  ? 234 SER A CA  1 
ATOM 1620 C C   . SER A 1 234 ? 86.121  112.336 67.496  1.00 63.22  ? 234 SER A C   1 
ATOM 1621 O O   . SER A 1 234 ? 86.112  112.911 68.591  1.00 63.22  ? 234 SER A O   1 
ATOM 1622 C CB  . SER A 1 234 ? 87.573  113.256 65.665  1.00 63.22  ? 234 SER A CB  1 
ATOM 1623 O OG  . SER A 1 234 ? 86.472  113.268 64.775  1.00 63.22  ? 234 SER A OG  1 
ATOM 1624 N N   . SER A 1 235 ? 85.009  111.855 66.938  1.00 60.68  ? 235 SER A N   1 
ATOM 1625 C CA  . SER A 1 235 ? 83.744  111.880 67.664  1.00 60.68  ? 235 SER A CA  1 
ATOM 1626 C C   . SER A 1 235 ? 83.777  110.942 68.865  1.00 60.68  ? 235 SER A C   1 
ATOM 1627 O O   . SER A 1 235 ? 83.139  111.210 69.890  1.00 60.68  ? 235 SER A O   1 
ATOM 1628 C CB  . SER A 1 235 ? 82.596  111.509 66.726  1.00 60.68  ? 235 SER A CB  1 
ATOM 1629 O OG  . SER A 1 235 ? 82.933  110.387 65.929  1.00 60.68  ? 235 SER A OG  1 
ATOM 1630 N N   . GLU A 1 236 ? 84.515  109.835 68.755  1.00 56.64  ? 236 GLU A N   1 
ATOM 1631 C CA  . GLU A 1 236 ? 84.528  108.829 69.811  1.00 56.64  ? 236 GLU A CA  1 
ATOM 1632 C C   . GLU A 1 236 ? 85.458  109.187 70.964  1.00 56.64  ? 236 GLU A C   1 
ATOM 1633 O O   . GLU A 1 236 ? 85.440  108.487 71.983  1.00 56.64  ? 236 GLU A O   1 
ATOM 1634 C CB  . GLU A 1 236 ? 84.924  107.471 69.233  1.00 56.64  ? 236 GLU A CB  1 
ATOM 1635 C CG  . GLU A 1 236 ? 83.897  106.873 68.291  1.00 56.64  ? 236 GLU A CG  1 
ATOM 1636 C CD  . GLU A 1 236 ? 84.347  105.550 67.703  1.00 56.64  ? 236 GLU A CD  1 
ATOM 1637 O OE1 . GLU A 1 236 ? 85.515  105.167 67.923  1.00 56.64  ? 236 GLU A OE1 1 
ATOM 1638 O OE2 . GLU A 1 236 ? 83.533  104.892 67.022  1.00 56.64  ? 236 GLU A OE2 1 
ATOM 1639 N N   . VAL A 1 237 ? 86.259  110.251 70.828  1.00 50.67  ? 237 VAL A N   1 
ATOM 1640 C CA  . VAL A 1 237 ? 87.215  110.622 71.874  1.00 50.67  ? 237 VAL A CA  1 
ATOM 1641 C C   . VAL A 1 237 ? 86.495  110.913 73.183  1.00 50.67  ? 237 VAL A C   1 
ATOM 1642 O O   . VAL A 1 237 ? 86.875  110.403 74.245  1.00 50.67  ? 237 VAL A O   1 
ATOM 1643 C CB  . VAL A 1 237 ? 88.066  111.824 71.421  1.00 50.67  ? 237 VAL A CB  1 
ATOM 1644 C CG1 . VAL A 1 237 ? 88.884  112.364 72.580  1.00 50.67  ? 237 VAL A CG1 1 
ATOM 1645 C CG2 . VAL A 1 237 ? 88.981  111.425 70.283  1.00 50.67  ? 237 VAL A CG2 1 
ATOM 1646 N N   . TYR A 1 238 ? 85.426  111.710 73.122  1.00 52.67  ? 238 TYR A N   1 
ATOM 1647 C CA  . TYR A 1 238 ? 84.621  111.967 74.311  1.00 52.67  ? 238 TYR A CA  1 
ATOM 1648 C C   . TYR A 1 238 ? 83.991  110.682 74.832  1.00 52.67  ? 238 TYR A C   1 
ATOM 1649 O O   . TYR A 1 238 ? 83.799  110.524 76.043  1.00 52.67  ? 238 TYR A O   1 
ATOM 1650 C CB  . TYR A 1 238 ? 83.545  113.006 74.002  1.00 52.67  ? 238 TYR A CB  1 
ATOM 1651 C CG  . TYR A 1 238 ? 84.093  114.390 73.744  1.00 52.67  ? 238 TYR A CG  1 
ATOM 1652 C CD1 . TYR A 1 238 ? 85.075  114.932 74.561  1.00 52.67  ? 238 TYR A CD1 1 
ATOM 1653 C CD2 . TYR A 1 238 ? 83.629  115.153 72.680  1.00 52.67  ? 238 TYR A CD2 1 
ATOM 1654 C CE1 . TYR A 1 238 ? 85.579  116.196 74.328  1.00 52.67  ? 238 TYR A CE1 1 
ATOM 1655 C CE2 . TYR A 1 238 ? 84.128  116.418 72.438  1.00 52.67  ? 238 TYR A CE2 1 
ATOM 1656 C CZ  . TYR A 1 238 ? 85.102  116.934 73.265  1.00 52.67  ? 238 TYR A CZ  1 
ATOM 1657 O OH  . TYR A 1 238 ? 85.602  118.194 73.029  1.00 52.67  ? 238 TYR A OH  1 
ATOM 1658 N N   . SER A 1 239 ? 83.658  109.757 73.929  1.00 48.43  ? 239 SER A N   1 
ATOM 1659 C CA  . SER A 1 239 ? 83.235  108.430 74.358  1.00 48.43  ? 239 SER A CA  1 
ATOM 1660 C C   . SER A 1 239 ? 84.385  107.678 75.016  1.00 48.43  ? 239 SER A C   1 
ATOM 1661 O O   . SER A 1 239 ? 84.203  107.047 76.065  1.00 48.43  ? 239 SER A O   1 
ATOM 1662 C CB  . SER A 1 239 ? 82.688  107.646 73.166  1.00 48.43  ? 239 SER A CB  1 
ATOM 1663 O OG  . SER A 1 239 ? 82.166  106.393 73.569  1.00 48.43  ? 239 SER A OG  1 
ATOM 1664 N N   . TRP A 1 240 ? 85.585  107.767 74.427  1.00 41.35  ? 240 TRP A N   1 
ATOM 1665 C CA  . TRP A 1 240 ? 86.722  106.968 74.881  1.00 41.35  ? 240 TRP A CA  1 
ATOM 1666 C C   . TRP A 1 240 ? 87.083  107.292 76.323  1.00 41.35  ? 240 TRP A C   1 
ATOM 1667 O O   . TRP A 1 240 ? 87.159  106.395 77.172  1.00 41.35  ? 240 TRP A O   1 
ATOM 1668 C CB  . TRP A 1 240 ? 87.918  107.203 73.957  1.00 41.35  ? 240 TRP A CB  1 
ATOM 1669 C CG  . TRP A 1 240 ? 89.041  106.230 74.141  1.00 41.35  ? 240 TRP A CG  1 
ATOM 1670 C CD1 . TRP A 1 240 ? 89.202  105.037 73.505  1.00 41.35  ? 240 TRP A CD1 1 
ATOM 1671 C CD2 . TRP A 1 240 ? 90.169  106.376 75.010  1.00 41.35  ? 240 TRP A CD2 1 
ATOM 1672 N NE1 . TRP A 1 240 ? 90.355  104.426 73.928  1.00 41.35  ? 240 TRP A NE1 1 
ATOM 1673 C CE2 . TRP A 1 240 ? 90.968  105.229 74.853  1.00 41.35  ? 240 TRP A CE2 1 
ATOM 1674 C CE3 . TRP A 1 240 ? 90.580  107.365 75.909  1.00 41.35  ? 240 TRP A CE3 1 
ATOM 1675 C CZ2 . TRP A 1 240 ? 92.152  105.041 75.560  1.00 41.35  ? 240 TRP A CZ2 1 
ATOM 1676 C CZ3 . TRP A 1 240 ? 91.755  107.177 76.610  1.00 41.35  ? 240 TRP A CZ3 1 
ATOM 1677 C CH2 . TRP A 1 240 ? 92.527  106.025 76.432  1.00 41.35  ? 240 TRP A CH2 1 
ATOM 1678 N N   . LEU A 1 241 ? 87.271  108.581 76.621  1.00 40.30  ? 241 LEU A N   1 
ATOM 1679 C CA  . LEU A 1 241 ? 87.505  109.011 77.994  1.00 40.30  ? 241 LEU A CA  1 
ATOM 1680 C C   . LEU A 1 241 ? 86.360  108.587 78.903  1.00 40.30  ? 241 LEU A C   1 
ATOM 1681 O O   . LEU A 1 241 ? 86.590  108.191 80.052  1.00 40.30  ? 241 LEU A O   1 
ATOM 1682 C CB  . LEU A 1 241 ? 87.691  110.527 78.038  1.00 40.30  ? 241 LEU A CB  1 
ATOM 1683 C CG  . LEU A 1 241 ? 88.852  111.096 77.221  1.00 40.30  ? 241 LEU A CG  1 
ATOM 1684 C CD1 . LEU A 1 241 ? 88.737  112.606 77.116  1.00 40.30  ? 241 LEU A CD1 1 
ATOM 1685 C CD2 . LEU A 1 241 ? 90.185  110.700 77.830  1.00 40.30  ? 241 LEU A CD2 1 
ATOM 1686 N N   . ASP A 1 242 ? 85.128  108.622 78.383  1.00 44.29  ? 242 ASP A N   1 
ATOM 1687 C CA  . ASP A 1 242 ? 83.968  108.188 79.154  1.00 44.29  ? 242 ASP A CA  1 
ATOM 1688 C C   . ASP A 1 242 ? 84.113  106.733 79.578  1.00 44.29  ? 242 ASP A C   1 
ATOM 1689 O O   . ASP A 1 242 ? 83.733  106.357 80.693  1.00 44.29  ? 242 ASP A O   1 
ATOM 1690 C CB  . ASP A 1 242 ? 82.692  108.387 78.336  1.00 44.29  ? 242 ASP A CB  1 
ATOM 1691 C CG  . ASP A 1 242 ? 81.438  108.050 79.116  1.00 44.29  ? 242 ASP A CG  1 
ATOM 1692 O OD1 . ASP A 1 242 ? 81.446  108.198 80.356  1.00 44.29  ? 242 ASP A OD1 1 
ATOM 1693 O OD2 . ASP A 1 242 ? 80.442  107.633 78.489  1.00 44.29  ? 242 ASP A OD2 1 
ATOM 1694 N N   . SER A 1 243 ? 84.671  105.898 78.701  1.00 39.02  ? 243 SER A N   1 
ATOM 1695 C CA  . SER A 1 243 ? 84.986  104.535 79.104  1.00 39.02  ? 243 SER A CA  1 
ATOM 1696 C C   . SER A 1 243 ? 86.187  104.515 80.039  1.00 39.02  ? 243 SER A C   1 
ATOM 1697 O O   . SER A 1 243 ? 86.185  103.811 81.055  1.00 39.02  ? 243 SER A O   1 
ATOM 1698 C CB  . SER A 1 243 ? 85.236  103.665 77.874  1.00 39.02  ? 243 SER A CB  1 
ATOM 1699 O OG  . SER A 1 243 ? 84.015  103.262 77.282  1.00 39.02  ? 243 SER A OG  1 
ATOM 1700 N N   . PHE A 1 244 ? 87.215  105.310 79.723  1.00 37.40  ? 244 PHE A N   1 
ATOM 1701 C CA  . PHE A 1 244 ? 88.465  105.233 80.473  1.00 37.40  ? 244 PHE A CA  1 
ATOM 1702 C C   . PHE A 1 244 ? 88.287  105.725 81.901  1.00 37.40  ? 244 PHE A C   1 
ATOM 1703 O O   . PHE A 1 244 ? 88.853  105.153 82.837  1.00 37.40  ? 244 PHE A O   1 
ATOM 1704 C CB  . PHE A 1 244 ? 89.561  106.027 79.766  1.00 37.40  ? 244 PHE A CB  1 
ATOM 1705 C CG  . PHE A 1 244 ? 90.946  105.665 80.212  1.00 37.40  ? 244 PHE A CG  1 
ATOM 1706 C CD1 . PHE A 1 244 ? 91.562  104.521 79.735  1.00 37.40  ? 244 PHE A CD1 1 
ATOM 1707 C CD2 . PHE A 1 244 ? 91.626  106.459 81.119  1.00 37.40  ? 244 PHE A CD2 1 
ATOM 1708 C CE1 . PHE A 1 244 ? 92.833  104.179 80.147  1.00 37.40  ? 244 PHE A CE1 1 
ATOM 1709 C CE2 . PHE A 1 244 ? 92.898  106.122 81.536  1.00 37.40  ? 244 PHE A CE2 1 
ATOM 1710 C CZ  . PHE A 1 244 ? 93.502  104.981 81.049  1.00 37.40  ? 244 PHE A CZ  1 
ATOM 1711 N N   . LEU A 1 245 ? 87.502  106.787 82.087  1.00 36.12  ? 245 LEU A N   1 
ATOM 1712 C CA  . LEU A 1 245 ? 87.180  107.233 83.435  1.00 36.12  ? 245 LEU A CA  1 
ATOM 1713 C C   . LEU A 1 245 ? 86.302  106.222 84.159  1.00 36.12  ? 245 LEU A C   1 
ATOM 1714 O O   . LEU A 1 245 ? 86.319  106.161 85.393  1.00 36.12  ? 245 LEU A O   1 
ATOM 1715 C CB  . LEU A 1 245 ? 86.494  108.597 83.385  1.00 36.12  ? 245 LEU A CB  1 
ATOM 1716 C CG  . LEU A 1 245 ? 87.366  109.790 82.989  1.00 36.12  ? 245 LEU A CG  1 
ATOM 1717 C CD1 . LEU A 1 245 ? 86.601  111.090 83.161  1.00 36.12  ? 245 LEU A CD1 1 
ATOM 1718 C CD2 . LEU A 1 245 ? 88.651  109.814 83.796  1.00 36.12  ? 245 LEU A CD2 1 
ATOM 1719 N N   . LEU A 1 246 ? 85.532  105.424 83.414  1.00 37.15  ? 246 LEU A N   1 
ATOM 1720 C CA  . LEU A 1 246 ? 84.669  104.430 84.042  1.00 37.15  ? 246 LEU A CA  1 
ATOM 1721 C C   . LEU A 1 246 ? 85.479  103.295 84.653  1.00 37.15  ? 246 LEU A C   1 
ATOM 1722 O O   . LEU A 1 246 ? 85.185  102.846 85.766  1.00 37.15  ? 246 LEU A O   1 
ATOM 1723 C CB  . LEU A 1 246 ? 83.665  103.895 83.020  1.00 37.15  ? 246 LEU A CB  1 
ATOM 1724 C CG  . LEU A 1 246 ? 82.592  102.909 83.487  1.00 37.15  ? 246 LEU A CG  1 
ATOM 1725 C CD1 . LEU A 1 246 ? 81.283  103.230 82.812  1.00 37.15  ? 246 LEU A CD1 1 
ATOM 1726 C CD2 . LEU A 1 246 ? 82.990  101.477 83.169  1.00 37.15  ? 246 LEU A CD2 1 
ATOM 1727 N N   . LEU A 1 247 ? 86.493  102.810 83.938  1.00 35.83  ? 247 LEU A N   1 
ATOM 1728 C CA  . LEU A 1 247 ? 87.279  101.687 84.432  1.00 35.83  ? 247 LEU A CA  1 
ATOM 1729 C C   . LEU A 1 247 ? 88.340  102.135 85.429  1.00 35.83  ? 247 LEU A C   1 
ATOM 1730 O O   . LEU A 1 247 ? 88.657  101.403 86.372  1.00 35.83  ? 247 LEU A O   1 
ATOM 1731 C CB  . LEU A 1 247 ? 87.917  100.949 83.259  1.00 35.83  ? 247 LEU A CB  1 
ATOM 1732 C CG  . LEU A 1 247 ? 86.910  100.237 82.358  1.00 35.83  ? 247 LEU A CG  1 
ATOM 1733 C CD1 . LEU A 1 247 ? 87.423  100.163 80.936  1.00 35.83  ? 247 LEU A CD1 1 
ATOM 1734 C CD2 . LEU A 1 247 ? 86.599  98.852  82.889  1.00 35.83  ? 247 LEU A CD2 1 
ATOM 1735 N N   . MET A 1 248 ? 88.897  103.332 85.239  1.00 37.00  ? 248 MET A N   1 
ATOM 1736 C CA  . MET A 1 248 ? 89.948  103.809 86.131  1.00 37.00  ? 248 MET A CA  1 
ATOM 1737 C C   . MET A 1 248 ? 89.383  104.239 87.480  1.00 37.00  ? 248 MET A C   1 
ATOM 1738 O O   . MET A 1 248 ? 90.005  104.007 88.521  1.00 37.00  ? 248 MET A O   1 
ATOM 1739 C CB  . MET A 1 248 ? 90.707  104.960 85.474  1.00 37.00  ? 248 MET A CB  1 
ATOM 1740 C CG  . MET A 1 248 ? 91.857  105.497 86.294  1.00 37.00  ? 248 MET A CG  1 
ATOM 1741 S SD  . MET A 1 248 ? 92.725  106.832 85.456  1.00 37.00  ? 248 MET A SD  1 
ATOM 1742 C CE  . MET A 1 248 ? 91.517  108.145 85.585  1.00 37.00  ? 248 MET A CE  1 
ATOM 1743 N N   . LEU A 1 249 ? 88.214  104.874 87.485  1.00 35.87  ? 249 LEU A N   1 
ATOM 1744 C CA  . LEU A 1 249 ? 87.611  105.338 88.726  1.00 35.87  ? 249 LEU A CA  1 
ATOM 1745 C C   . LEU A 1 249 ? 86.592  104.365 89.300  1.00 35.87  ? 249 LEU A C   1 
ATOM 1746 O O   . LEU A 1 249 ? 86.380  104.356 90.515  1.00 35.87  ? 249 LEU A O   1 
ATOM 1747 C CB  . LEU A 1 249 ? 86.949  106.703 88.515  1.00 35.87  ? 249 LEU A CB  1 
ATOM 1748 C CG  . LEU A 1 249 ? 87.867  107.794 87.960  1.00 35.87  ? 249 LEU A CG  1 
ATOM 1749 C CD1 . LEU A 1 249 ? 87.127  109.115 87.824  1.00 35.87  ? 249 LEU A CD1 1 
ATOM 1750 C CD2 . LEU A 1 249 ? 89.095  107.956 88.836  1.00 35.87  ? 249 LEU A CD2 1 
ATOM 1751 N N   . GLY A 1 250 ? 85.955  103.548 88.459  1.00 37.76  ? 250 GLY A N   1 
ATOM 1752 C CA  . GLY A 1 250 ? 85.038  102.541 88.959  1.00 37.76  ? 250 GLY A CA  1 
ATOM 1753 C C   . GLY A 1 250 ? 85.719  101.332 89.560  1.00 37.76  ? 250 GLY A C   1 
ATOM 1754 O O   . GLY A 1 250 ? 85.087  100.594 90.323  1.00 37.76  ? 250 GLY A O   1 
ATOM 1755 N N   . GLY A 1 251 ? 86.994  101.109 89.231  1.00 39.70  ? 251 GLY A N   1 
ATOM 1756 C CA  . GLY A 1 251 ? 87.732  99.994  89.796  1.00 39.70  ? 251 GLY A CA  1 
ATOM 1757 C C   . GLY A 1 251 ? 88.288  100.240 91.181  1.00 39.70  ? 251 GLY A C   1 
ATOM 1758 O O   . GLY A 1 251 ? 88.825  99.311  91.792  1.00 39.70  ? 251 GLY A O   1 
ATOM 1759 N N   . ILE A 1 252 ? 88.179  101.463 91.689  1.00 41.63  ? 252 ILE A N   1 
ATOM 1760 C CA  . ILE A 1 252 ? 88.699  101.801 93.013  1.00 41.63  ? 252 ILE A CA  1 
ATOM 1761 C C   . ILE A 1 252 ? 87.768  101.307 94.122  1.00 41.63  ? 252 ILE A C   1 
ATOM 1762 O O   . ILE A 1 252 ? 88.237  100.584 95.012  1.00 41.63  ? 252 ILE A O   1 
ATOM 1763 C CB  . ILE A 1 252 ? 88.970  103.312 93.136  1.00 41.63  ? 252 ILE A CB  1 
ATOM 1764 C CG1 . ILE A 1 252 ? 89.993  103.761 92.092  1.00 41.63  ? 252 ILE A CG1 1 
ATOM 1765 C CG2 . ILE A 1 252 ? 89.448  103.657 94.534  1.00 41.63  ? 252 ILE A CG2 1 
ATOM 1766 C CD1 . ILE A 1 252 ? 90.165  105.258 92.017  1.00 41.63  ? 252 ILE A CD1 1 
ATOM 1767 N N   . PRO A 1 253 ? 86.449  101.647 94.141  1.00 45.80  ? 253 PRO A N   1 
ATOM 1768 C CA  . PRO A 1 253 ? 85.682  101.210 95.332  1.00 45.80  ? 253 PRO A CA  1 
ATOM 1769 C C   . PRO A 1 253 ? 85.238  99.749  95.289  1.00 45.80  ? 253 PRO A C   1 
ATOM 1770 O O   . PRO A 1 253 ? 84.085  99.403  95.037  1.00 45.80  ? 253 PRO A O   1 
ATOM 1771 C CB  . PRO A 1 253 ? 84.488  102.165 95.326  1.00 45.80  ? 253 PRO A CB  1 
ATOM 1772 C CG  . PRO A 1 253 ? 84.264  102.460 93.909  1.00 45.80  ? 253 PRO A CG  1 
ATOM 1773 C CD  . PRO A 1 253 ? 85.599  102.444 93.231  1.00 45.80  ? 253 PRO A CD  1 
ATOM 1774 N N   . TRP A 1 254 ? 86.184  98.852  95.559  1.00 48.32  ? 254 TRP A N   1 
ATOM 1775 C CA  . TRP A 1 254 ? 85.921  97.422  95.566  1.00 48.32  ? 254 TRP A CA  1 
ATOM 1776 C C   . TRP A 1 254 ? 86.385  96.833  96.889  1.00 48.32  ? 254 TRP A C   1 
ATOM 1777 O O   . TRP A 1 254 ? 87.380  97.284  97.463  1.00 48.32  ? 254 TRP A O   1 
ATOM 1778 C CB  . TRP A 1 254 ? 86.615  96.724  94.399  1.00 48.32  ? 254 TRP A CB  1 
ATOM 1779 C CG  . TRP A 1 254 ? 85.900  96.921  93.100  1.00 48.32  ? 254 TRP A CG  1 
ATOM 1780 C CD1 . TRP A 1 254 ? 85.978  98.008  92.284  1.00 48.32  ? 254 TRP A CD1 1 
ATOM 1781 C CD2 . TRP A 1 254 ? 84.985  96.016  92.475  1.00 48.32  ? 254 TRP A CD2 1 
ATOM 1782 N NE1 . TRP A 1 254 ? 85.177  97.835  91.185  1.00 48.32  ? 254 TRP A NE1 1 
ATOM 1783 C CE2 . TRP A 1 254 ? 84.556  96.619  91.277  1.00 48.32  ? 254 TRP A CE2 1 
ATOM 1784 C CE3 . TRP A 1 254 ? 84.491  94.752  92.807  1.00 48.32  ? 254 TRP A CE3 1 
ATOM 1785 C CZ2 . TRP A 1 254 ? 83.658  96.004  90.412  1.00 48.32  ? 254 TRP A CZ2 1 
ATOM 1786 C CZ3 . TRP A 1 254 ? 83.599  94.143  91.946  1.00 48.32  ? 254 TRP A CZ3 1 
ATOM 1787 C CH2 . TRP A 1 254 ? 83.193  94.770  90.763  1.00 48.32  ? 254 TRP A CH2 1 
ATOM 1788 N N   . GLN A 1 255 ? 85.651  95.825  97.369  1.00 62.72  ? 255 GLN A N   1 
ATOM 1789 C CA  . GLN A 1 255 ? 85.909  95.272  98.696  1.00 62.72  ? 255 GLN A CA  1 
ATOM 1790 C C   . GLN A 1 255 ? 87.228  94.508  98.759  1.00 62.72  ? 255 GLN A C   1 
ATOM 1791 O O   . GLN A 1 255 ? 87.949  94.606  99.760  1.00 62.72  ? 255 GLN A O   1 
ATOM 1792 C CB  . GLN A 1 255 ? 84.752  94.365  99.109  1.00 62.72  ? 255 GLN A CB  1 
ATOM 1793 C CG  . GLN A 1 255 ? 84.877  93.791  100.506 1.00 62.72  ? 255 GLN A CG  1 
ATOM 1794 C CD  . GLN A 1 255 ? 84.889  94.868  101.569 1.00 62.72  ? 255 GLN A CD  1 
ATOM 1795 O OE1 . GLN A 1 255 ? 85.933  95.188  102.137 1.00 62.72  ? 255 GLN A OE1 1 
ATOM 1796 N NE2 . GLN A 1 255 ? 83.723  95.441  101.838 1.00 62.72  ? 255 GLN A NE2 1 
ATOM 1797 N N   . ALA A 1 256 ? 87.557  93.749  97.708  1.00 60.89  ? 256 ALA A N   1 
ATOM 1798 C CA  . ALA A 1 256 ? 88.751  92.907  97.728  1.00 60.89  ? 256 ALA A CA  1 
ATOM 1799 C C   . ALA A 1 256 ? 90.024  93.738  97.819  1.00 60.89  ? 256 ALA A C   1 
ATOM 1800 O O   . ALA A 1 256 ? 90.987  93.343  98.486  1.00 60.89  ? 256 ALA A O   1 
ATOM 1801 C CB  . ALA A 1 256 ? 88.782  92.014  96.489  1.00 60.89  ? 256 ALA A CB  1 
ATOM 1802 N N   . TYR A 1 257 ? 90.053  94.885  97.142  1.00 59.26  ? 257 TYR A N   1 
ATOM 1803 C CA  . TYR A 1 257 ? 91.195  95.788  97.240  1.00 59.26  ? 257 TYR A CA  1 
ATOM 1804 C C   . TYR A 1 257 ? 91.273  96.425  98.624  1.00 59.26  ? 257 TYR A C   1 
ATOM 1805 O O   . TYR A 1 257 ? 92.329  96.416  99.273  1.00 59.26  ? 257 TYR A O   1 
ATOM 1806 C CB  . TYR A 1 257 ? 91.078  96.859  96.155  1.00 59.26  ? 257 TYR A CB  1 
ATOM 1807 C CG  . TYR A 1 257 ? 92.049  98.013  96.261  1.00 59.26  ? 257 TYR A CG  1 
ATOM 1808 C CD1 . TYR A 1 257 ? 93.416  97.809  96.152  1.00 59.26  ? 257 TYR A CD1 1 
ATOM 1809 C CD2 . TYR A 1 257 ? 91.595  99.308  96.466  1.00 59.26  ? 257 TYR A CD2 1 
ATOM 1810 C CE1 . TYR A 1 257 ? 94.304  98.862  96.235  1.00 59.26  ? 257 TYR A CE1 1 
ATOM 1811 C CE2 . TYR A 1 257 ? 92.474  100.366 96.560  1.00 59.26  ? 257 TYR A CE2 1 
ATOM 1812 C CZ  . TYR A 1 257 ? 93.827  100.136 96.444  1.00 59.26  ? 257 TYR A CZ  1 
ATOM 1813 O OH  . TYR A 1 257 ? 94.707  101.187 96.537  1.00 59.26  ? 257 TYR A OH  1 
ATOM 1814 N N   . PHE A 1 258 ? 90.146  96.951  99.107  1.00 61.49  ? 258 PHE A N   1 
ATOM 1815 C CA  . PHE A 1 258 ? 90.173  97.792  100.297 1.00 61.49  ? 258 PHE A CA  1 
ATOM 1816 C C   . PHE A 1 258 ? 90.367  96.982  101.571 1.00 61.49  ? 258 PHE A C   1 
ATOM 1817 O O   . PHE A 1 258 ? 90.902  97.508  102.554 1.00 61.49  ? 258 PHE A O   1 
ATOM 1818 C CB  . PHE A 1 258 ? 88.896  98.623  100.376 1.00 61.49  ? 258 PHE A CB  1 
ATOM 1819 C CG  . PHE A 1 258 ? 89.045  100.005 99.817  1.00 61.49  ? 258 PHE A CG  1 
ATOM 1820 C CD1 . PHE A 1 258 ? 89.899  100.916 100.409 1.00 61.49  ? 258 PHE A CD1 1 
ATOM 1821 C CD2 . PHE A 1 258 ? 88.336  100.390 98.693  1.00 61.49  ? 258 PHE A CD2 1 
ATOM 1822 C CE1 . PHE A 1 258 ? 90.042  102.187 99.890  1.00 61.49  ? 258 PHE A CE1 1 
ATOM 1823 C CE2 . PHE A 1 258 ? 88.470  101.660 98.175  1.00 61.49  ? 258 PHE A CE2 1 
ATOM 1824 C CZ  . PHE A 1 258 ? 89.324  102.559 98.773  1.00 61.49  ? 258 PHE A CZ  1 
ATOM 1825 N N   . GLN A 1 259 ? 89.959  95.708  101.579 1.00 69.28  ? 259 GLN A N   1 
ATOM 1826 C CA  . GLN A 1 259 ? 90.179  94.884  102.766 1.00 69.28  ? 259 GLN A CA  1 
ATOM 1827 C C   . GLN A 1 259 ? 91.670  94.671  103.019 1.00 69.28  ? 259 GLN A C   1 
ATOM 1828 O O   . GLN A 1 259 ? 92.136  94.764  104.160 1.00 69.28  ? 259 GLN A O   1 
ATOM 1829 C CB  . GLN A 1 259 ? 89.429  93.550  102.639 1.00 69.28  ? 259 GLN A CB  1 
ATOM 1830 C CG  . GLN A 1 259 ? 89.889  92.615  101.529 1.00 69.28  ? 259 GLN A CG  1 
ATOM 1831 C CD  . GLN A 1 259 ? 89.054  91.354  101.444 1.00 69.28  ? 259 GLN A CD  1 
ATOM 1832 O OE1 . GLN A 1 259 ? 88.150  91.139  102.250 1.00 69.28  ? 259 GLN A OE1 1 
ATOM 1833 N NE2 . GLN A 1 259 ? 89.352  90.513  100.461 1.00 69.28  ? 259 GLN A NE2 1 
ATOM 1834 N N   . ARG A 1 260 ? 92.446  94.427  101.959 1.00 69.12  ? 260 ARG A N   1 
ATOM 1835 C CA  . ARG A 1 260 ? 93.886  94.273  102.131 1.00 69.12  ? 260 ARG A CA  1 
ATOM 1836 C C   . ARG A 1 260 ? 94.570  95.625  102.308 1.00 69.12  ? 260 ARG A C   1 
ATOM 1837 O O   . ARG A 1 260 ? 95.620  95.711  102.956 1.00 69.12  ? 260 ARG A O   1 
ATOM 1838 C CB  . ARG A 1 260 ? 94.481  93.500  100.955 1.00 69.12  ? 260 ARG A CB  1 
ATOM 1839 C CG  . ARG A 1 260 ? 95.965  93.172  101.109 1.00 69.12  ? 260 ARG A CG  1 
ATOM 1840 C CD  . ARG A 1 260 ? 96.274  91.718  100.818 1.00 69.12  ? 260 ARG A CD  1 
ATOM 1841 N NE  . ARG A 1 260 ? 97.691  91.429  101.007 1.00 69.12  ? 260 ARG A NE  1 
ATOM 1842 C CZ  . ARG A 1 260 ? 98.213  90.923  102.116 1.00 69.12  ? 260 ARG A CZ  1 
ATOM 1843 N NH1 . ARG A 1 260 ? 97.459  90.621  103.160 1.00 69.12  ? 260 ARG A NH1 1 
ATOM 1844 N NH2 . ARG A 1 260 ? 99.525  90.716  102.180 1.00 69.12  ? 260 ARG A NH2 1 
ATOM 1845 N N   . VAL A 1 261 ? 93.996  96.693  101.744 1.00 67.37  ? 261 VAL A N   1 
ATOM 1846 C CA  . VAL A 1 261 ? 94.532  98.032  101.998 1.00 67.37  ? 261 VAL A CA  1 
ATOM 1847 C C   . VAL A 1 261 ? 94.444  98.375  103.482 1.00 67.37  ? 261 VAL A C   1 
ATOM 1848 O O   . VAL A 1 261 ? 95.413  98.851  104.086 1.00 67.37  ? 261 VAL A O   1 
ATOM 1849 C CB  . VAL A 1 261 ? 93.808  99.077  101.133 1.00 67.37  ? 261 VAL A CB  1 
ATOM 1850 C CG1 . VAL A 1 261 ? 94.105  100.485 101.631 1.00 67.37  ? 261 VAL A CG1 1 
ATOM 1851 C CG2 . VAL A 1 261 ? 94.259  98.949  99.708  1.00 67.37  ? 261 VAL A CG2 1 
ATOM 1852 N N   . LEU A 1 262 ? 93.284  98.130  104.095 1.00 72.15  ? 262 LEU A N   1 
ATOM 1853 C CA  . LEU A 1 262 ? 93.112  98.467  105.505 1.00 72.15  ? 262 LEU A CA  1 
ATOM 1854 C C   . LEU A 1 262 ? 93.741  97.416  106.414 1.00 72.15  ? 262 LEU A C   1 
ATOM 1855 O O   . LEU A 1 262 ? 94.013  97.690  107.588 1.00 72.15  ? 262 LEU A O   1 
ATOM 1856 C CB  . LEU A 1 262 ? 91.628  98.647  105.820 1.00 72.15  ? 262 LEU A CB  1 
ATOM 1857 C CG  . LEU A 1 262 ? 90.943  99.736  104.988 1.00 72.15  ? 262 LEU A CG  1 
ATOM 1858 C CD1 . LEU A 1 262 ? 89.433  99.570  105.000 1.00 72.15  ? 262 LEU A CD1 1 
ATOM 1859 C CD2 . LEU A 1 262 ? 91.345  101.122 105.475 1.00 72.15  ? 262 LEU A CD2 1 
ATOM 1860 N N   . SER A 1 263 ? 93.977  96.207  105.895 1.00 74.28  ? 263 SER A N   1 
ATOM 1861 C CA  . SER A 1 263 ? 94.589  95.163  106.712 1.00 74.28  ? 263 SER A CA  1 
ATOM 1862 C C   . SER A 1 263 ? 96.063  95.450  106.976 1.00 74.28  ? 263 SER A C   1 
ATOM 1863 O O   . SER A 1 263 ? 96.620  94.986  107.978 1.00 74.28  ? 263 SER A O   1 
ATOM 1864 C CB  . SER A 1 263 ? 94.425  93.801  106.037 1.00 74.28  ? 263 SER A CB  1 
ATOM 1865 O OG  . SER A 1 263 ? 95.382  93.626  105.007 1.00 74.28  ? 263 SER A OG  1 
ATOM 1866 N N   . SER A 1 264 ? 96.711  96.198  106.084 1.00 75.97  ? 264 SER A N   1 
ATOM 1867 C CA  . SER A 1 264 ? 98.135  96.487  106.216 1.00 75.97  ? 264 SER A CA  1 
ATOM 1868 C C   . SER A 1 264 ? 98.411  97.331  107.455 1.00 75.97  ? 264 SER A C   1 
ATOM 1869 O O   . SER A 1 264 ? 97.596  98.169  107.847 1.00 75.97  ? 264 SER A O   1 
ATOM 1870 C CB  . SER A 1 264 ? 98.642  97.204  104.964 1.00 75.97  ? 264 SER A CB  1 
ATOM 1871 O OG  . SER A 1 264 ? 98.306  96.478  103.795 1.00 75.97  ? 264 SER A OG  1 
ATOM 1872 N N   . SER A 1 265 ? 99.570  97.092  108.075 1.00 83.16  ? 265 SER A N   1 
ATOM 1873 C CA  . SER A 1 265 ? 99.895  97.764  109.330 1.00 83.16  ? 265 SER A CA  1 
ATOM 1874 C C   . SER A 1 265 ? 100.276 99.223  109.109 1.00 83.16  ? 265 SER A C   1 
ATOM 1875 O O   . SER A 1 265 ? 99.876  100.097 109.887 1.00 83.16  ? 265 SER A O   1 
ATOM 1876 C CB  . SER A 1 265 ? 101.021 97.018  110.045 1.00 83.16  ? 265 SER A CB  1 
ATOM 1877 O OG  . SER A 1 265 ? 101.103 97.404  111.407 1.00 83.16  ? 265 SER A OG  1 
ATOM 1878 N N   . SER A 1 266 ? 101.045 99.510  108.063 1.00 78.00  ? 266 SER A N   1 
ATOM 1879 C CA  . SER A 1 266 ? 101.547 100.854 107.811 1.00 78.00  ? 266 SER A CA  1 
ATOM 1880 C C   . SER A 1 266 ? 100.906 101.441 106.560 1.00 78.00  ? 266 SER A C   1 
ATOM 1881 O O   . SER A 1 266 ? 100.600 100.718 105.607 1.00 78.00  ? 266 SER A O   1 
ATOM 1882 C CB  . SER A 1 266 ? 103.069 100.848 107.663 1.00 78.00  ? 266 SER A CB  1 
ATOM 1883 O OG  . SER A 1 266 ? 103.560 102.153 107.410 1.00 78.00  ? 266 SER A OG  1 
ATOM 1884 N N   . ALA A 1 267 ? 100.696 102.761 106.577 1.00 75.43  ? 267 ALA A N   1 
ATOM 1885 C CA  . ALA A 1 267 ? 100.075 103.436 105.441 1.00 75.43  ? 267 ALA A CA  1 
ATOM 1886 C C   . ALA A 1 267 ? 100.996 103.443 104.228 1.00 75.43  ? 267 ALA A C   1 
ATOM 1887 O O   . ALA A 1 267 ? 100.564 103.159 103.103 1.00 75.43  ? 267 ALA A O   1 
ATOM 1888 C CB  . ALA A 1 267 ? 99.684  104.862 105.830 1.00 75.43  ? 267 ALA A CB  1 
ATOM 1889 N N   . THR A 1 268 ? 102.274 103.772 104.438 1.00 69.65  ? 268 THR A N   1 
ATOM 1890 C CA  . THR A 1 268 ? 103.237 103.755 103.340 1.00 69.65  ? 268 THR A CA  1 
ATOM 1891 C C   . THR A 1 268 ? 103.413 102.343 102.798 1.00 69.65  ? 268 THR A C   1 
ATOM 1892 O O   . THR A 1 268 ? 103.639 102.152 101.596 1.00 69.65  ? 268 THR A O   1 
ATOM 1893 C CB  . THR A 1 268 ? 104.576 104.327 103.808 1.00 69.65  ? 268 THR A CB  1 
ATOM 1894 O OG1 . THR A 1 268 ? 104.353 105.557 104.507 1.00 69.65  ? 268 THR A OG1 1 
ATOM 1895 C CG2 . THR A 1 268 ? 105.491 104.595 102.622 1.00 69.65  ? 268 THR A CG2 1 
ATOM 1896 N N   . TYR A 1 269 ? 103.292 101.342 103.673 1.00 68.57  ? 269 TYR A N   1 
ATOM 1897 C CA  . TYR A 1 269 ? 103.286 99.952  103.232 1.00 68.57  ? 269 TYR A CA  1 
ATOM 1898 C C   . TYR A 1 269 ? 102.118 99.688  102.290 1.00 68.57  ? 269 TYR A C   1 
ATOM 1899 O O   . TYR A 1 269 ? 102.276 99.026  101.261 1.00 68.57  ? 269 TYR A O   1 
ATOM 1900 C CB  . TYR A 1 269 ? 103.225 99.023  104.444 1.00 68.57  ? 269 TYR A CB  1 
ATOM 1901 C CG  . TYR A 1 269 ? 103.650 97.600  104.163 1.00 68.57  ? 269 TYR A CG  1 
ATOM 1902 C CD1 . TYR A 1 269 ? 104.992 97.267  104.039 1.00 68.57  ? 269 TYR A CD1 1 
ATOM 1903 C CD2 . TYR A 1 269 ? 102.709 96.587  104.027 1.00 68.57  ? 269 TYR A CD2 1 
ATOM 1904 C CE1 . TYR A 1 269 ? 105.385 95.967  103.788 1.00 68.57  ? 269 TYR A CE1 1 
ATOM 1905 C CE2 . TYR A 1 269 ? 103.092 95.284  103.773 1.00 68.57  ? 269 TYR A CE2 1 
ATOM 1906 C CZ  . TYR A 1 269 ? 104.431 94.981  103.653 1.00 68.57  ? 269 TYR A CZ  1 
ATOM 1907 O OH  . TYR A 1 269 ? 104.818 93.685  103.400 1.00 68.57  ? 269 TYR A OH  1 
ATOM 1908 N N   . ALA A 1 270 ? 100.938 100.220 102.620 1.00 62.98  ? 270 ALA A N   1 
ATOM 1909 C CA  . ALA A 1 270 ? 99.777  100.054 101.751 1.00 62.98  ? 270 ALA A CA  1 
ATOM 1910 C C   . ALA A 1 270 ? 99.978  100.752 100.410 1.00 62.98  ? 270 ALA A C   1 
ATOM 1911 O O   . ALA A 1 270 ? 99.618  100.206 99.360  1.00 62.98  ? 270 ALA A O   1 
ATOM 1912 C CB  . ALA A 1 270 ? 98.521  100.577 102.446 1.00 62.98  ? 270 ALA A CB  1 
ATOM 1913 N N   . GLN A 1 271 ? 100.556 101.957 100.424 1.00 59.26  ? 271 GLN A N   1 
ATOM 1914 C CA  . GLN A 1 271 ? 100.791 102.677 99.173  1.00 59.26  ? 271 GLN A CA  1 
ATOM 1915 C C   . GLN A 1 271 ? 101.792 101.949 98.281  1.00 59.26  ? 271 GLN A C   1 
ATOM 1916 O O   . GLN A 1 271 ? 101.574 101.824 97.067  1.00 59.26  ? 271 GLN A O   1 
ATOM 1917 C CB  . GLN A 1 271 ? 101.275 104.098 99.460  1.00 59.26  ? 271 GLN A CB  1 
ATOM 1918 C CG  . GLN A 1 271 ? 100.395 104.880 100.414 1.00 59.26  ? 271 GLN A CG  1 
ATOM 1919 C CD  . GLN A 1 271 ? 100.496 106.375 100.201 1.00 59.26  ? 271 GLN A CD  1 
ATOM 1920 O OE1 . GLN A 1 271 ? 101.275 106.843 99.372  1.00 59.26  ? 271 GLN A OE1 1 
ATOM 1921 N NE2 . GLN A 1 271 ? 99.706  107.134 100.951 1.00 59.26  ? 271 GLN A NE2 1 
ATOM 1922 N N   . VAL A 1 272 ? 102.892 101.457 98.856  1.00 58.16  ? 272 VAL A N   1 
ATOM 1923 C CA  . VAL A 1 272 ? 103.885 100.763 98.040  1.00 58.16  ? 272 VAL A CA  1 
ATOM 1924 C C   . VAL A 1 272 ? 103.353 99.403  97.592  1.00 58.16  ? 272 VAL A C   1 
ATOM 1925 O O   . VAL A 1 272 ? 103.691 98.923  96.503  1.00 58.16  ? 272 VAL A O   1 
ATOM 1926 C CB  . VAL A 1 272 ? 105.234 100.660 98.784  1.00 58.16  ? 272 VAL A CB  1 
ATOM 1927 C CG1 . VAL A 1 272 ? 105.145 99.756  99.996  1.00 58.16  ? 272 VAL A CG1 1 
ATOM 1928 C CG2 . VAL A 1 272 ? 106.337 100.199 97.842  1.00 58.16  ? 272 VAL A CG2 1 
ATOM 1929 N N   . LEU A 1 273 ? 102.487 98.778  98.397  1.00 56.65  ? 273 LEU A N   1 
ATOM 1930 C CA  . LEU A 1 273 ? 101.828 97.549  97.968  1.00 56.65  ? 273 LEU A CA  1 
ATOM 1931 C C   . LEU A 1 273 ? 100.917 97.807  96.778  1.00 56.65  ? 273 LEU A C   1 
ATOM 1932 O O   . LEU A 1 273 ? 100.872 97.015  95.832  1.00 56.65  ? 273 LEU A O   1 
ATOM 1933 C CB  . LEU A 1 273 ? 101.033 96.944  99.127  1.00 56.65  ? 273 LEU A CB  1 
ATOM 1934 C CG  . LEU A 1 273 ? 101.770 96.012  100.091 1.00 56.65  ? 273 LEU A CG  1 
ATOM 1935 C CD1 . LEU A 1 273 ? 100.777 95.266  100.968 1.00 56.65  ? 273 LEU A CD1 1 
ATOM 1936 C CD2 . LEU A 1 273 ? 102.670 95.045  99.343  1.00 56.65  ? 273 LEU A CD2 1 
ATOM 1937 N N   . SER A 1 274 ? 100.183 98.923  96.809  1.00 48.25  ? 274 SER A N   1 
ATOM 1938 C CA  . SER A 1 274 ? 99.323  99.282  95.685  1.00 48.25  ? 274 SER A CA  1 
ATOM 1939 C C   . SER A 1 274 ? 100.139 99.578  94.433  1.00 48.25  ? 274 SER A C   1 
ATOM 1940 O O   . SER A 1 274 ? 99.746  99.197  93.324  1.00 48.25  ? 274 SER A O   1 
ATOM 1941 C CB  . SER A 1 274 ? 98.453  100.481 96.056  1.00 48.25  ? 274 SER A CB  1 
ATOM 1942 O OG  . SER A 1 274 ? 97.568  100.156 97.113  1.00 48.25  ? 274 SER A OG  1 
ATOM 1943 N N   . PHE A 1 275 ? 101.279 100.257 94.588  1.00 47.34  ? 275 PHE A N   1 
ATOM 1944 C CA  . PHE A 1 275 ? 102.145 100.530 93.442  1.00 47.34  ? 275 PHE A CA  1 
ATOM 1945 C C   . PHE A 1 275 ? 102.723 99.247  92.851  1.00 47.34  ? 275 PHE A C   1 
ATOM 1946 O O   . PHE A 1 275 ? 102.746 99.076  91.624  1.00 47.34  ? 275 PHE A O   1 
ATOM 1947 C CB  . PHE A 1 275 ? 103.272 101.484 93.844  1.00 47.34  ? 275 PHE A CB  1 
ATOM 1948 C CG  . PHE A 1 275 ? 102.810 102.883 94.163  1.00 47.34  ? 275 PHE A CG  1 
ATOM 1949 C CD1 . PHE A 1 275 ? 101.541 103.315 93.811  1.00 47.34  ? 275 PHE A CD1 1 
ATOM 1950 C CD2 . PHE A 1 275 ? 103.651 103.765 94.821  1.00 47.34  ? 275 PHE A CD2 1 
ATOM 1951 C CE1 . PHE A 1 275 ? 101.122 104.597 94.107  1.00 47.34  ? 275 PHE A CE1 1 
ATOM 1952 C CE2 . PHE A 1 275 ? 103.237 105.049 95.120  1.00 47.34  ? 275 PHE A CE2 1 
ATOM 1953 C CZ  . PHE A 1 275 ? 101.972 105.465 94.763  1.00 47.34  ? 275 PHE A CZ  1 
ATOM 1954 N N   . LEU A 1 276 ? 103.180 98.331  93.710  1.00 45.44  ? 276 LEU A N   1 
ATOM 1955 C CA  . LEU A 1 276 ? 103.688 97.046  93.240  1.00 45.44  ? 276 LEU A CA  1 
ATOM 1956 C C   . LEU A 1 276 ? 102.589 96.237  92.566  1.00 45.44  ? 276 LEU A C   1 
ATOM 1957 O O   . LEU A 1 276 ? 102.837 95.531  91.585  1.00 45.44  ? 276 LEU A O   1 
ATOM 1958 C CB  . LEU A 1 276 ? 104.290 96.260  94.404  1.00 45.44  ? 276 LEU A CB  1 
ATOM 1959 C CG  . LEU A 1 276 ? 105.720 96.600  94.817  1.00 45.44  ? 276 LEU A CG  1 
ATOM 1960 C CD1 . LEU A 1 276 ? 106.146 95.712  95.968  1.00 45.44  ? 276 LEU A CD1 1 
ATOM 1961 C CD2 . LEU A 1 276 ? 106.664 96.443  93.640  1.00 45.44  ? 276 LEU A CD2 1 
ATOM 1962 N N   . ALA A 1 277 ? 101.366 96.318  93.092  1.00 40.82  ? 277 ALA A N   1 
ATOM 1963 C CA  . ALA A 1 277 ? 100.239 95.622  92.484  1.00 40.82  ? 277 ALA A CA  1 
ATOM 1964 C C   . ALA A 1 277 ? 99.899  96.189  91.117  1.00 40.82  ? 277 ALA A C   1 
ATOM 1965 O O   . ALA A 1 277 ? 99.542  95.441  90.203  1.00 40.82  ? 277 ALA A O   1 
ATOM 1966 C CB  . ALA A 1 277 ? 99.026  95.710  93.393  1.00 40.82  ? 277 ALA A CB  1 
ATOM 1967 N N   . ALA A 1 278 ? 99.960  97.512  90.970  1.00 38.63  ? 278 ALA A N   1 
ATOM 1968 C CA  . ALA A 1 278 ? 99.744  98.116  89.661  1.00 38.63  ? 278 ALA A CA  1 
ATOM 1969 C C   . ALA A 1 278 ? 100.816 97.676  88.675  1.00 38.63  ? 278 ALA A C   1 
ATOM 1970 O O   . ALA A 1 278 ? 100.516 97.370  87.513  1.00 38.63  ? 278 ALA A O   1 
ATOM 1971 C CB  . ALA A 1 278 ? 99.714  99.634  89.785  1.00 38.63  ? 278 ALA A CB  1 
ATOM 1972 N N   . PHE A 1 279 ? 102.071 97.618  89.129  1.00 40.52  ? 279 PHE A N   1 
ATOM 1973 C CA  . PHE A 1 279 ? 103.151 97.114  88.284  1.00 40.52  ? 279 PHE A CA  1 
ATOM 1974 C C   . PHE A 1 279 ? 102.912 95.659  87.890  1.00 40.52  ? 279 PHE A C   1 
ATOM 1975 O O   . PHE A 1 279 ? 103.100 95.280  86.729  1.00 40.52  ? 279 PHE A O   1 
ATOM 1976 C CB  . PHE A 1 279 ? 104.489 97.267  89.009  1.00 40.52  ? 279 PHE A CB  1 
ATOM 1977 C CG  . PHE A 1 279 ? 105.664 96.755  88.230  1.00 40.52  ? 279 PHE A CG  1 
ATOM 1978 C CD1 . PHE A 1 279 ? 106.154 97.461  87.145  1.00 40.52  ? 279 PHE A CD1 1 
ATOM 1979 C CD2 . PHE A 1 279 ? 106.282 95.567  88.586  1.00 40.52  ? 279 PHE A CD2 1 
ATOM 1980 C CE1 . PHE A 1 279 ? 107.237 96.991  86.427  1.00 40.52  ? 279 PHE A CE1 1 
ATOM 1981 C CE2 . PHE A 1 279 ? 107.364 95.091  87.873  1.00 40.52  ? 279 PHE A CE2 1 
ATOM 1982 C CZ  . PHE A 1 279 ? 107.843 95.804  86.792  1.00 40.52  ? 279 PHE A CZ  1 
ATOM 1983 N N   . GLY A 1 280 ? 102.485 94.834  88.846  1.00 40.14  ? 280 GLY A N   1 
ATOM 1984 C CA  . GLY A 1 280 ? 102.233 93.433  88.554  1.00 40.14  ? 280 GLY A CA  1 
ATOM 1985 C C   . GLY A 1 280 ? 101.056 93.225  87.622  1.00 40.14  ? 280 GLY A C   1 
ATOM 1986 O O   . GLY A 1 280 ? 101.079 92.336  86.772  1.00 40.14  ? 280 GLY A O   1 
ATOM 1987 N N   . CYS A 1 281 ? 100.007 94.035  87.777  1.00 39.94  ? 281 CYS A N   1 
ATOM 1988 C CA  . CYS A 1 281 ? 98.874  93.978  86.860  1.00 39.94  ? 281 CYS A CA  1 
ATOM 1989 C C   . CYS A 1 281 ? 99.286  94.395  85.456  1.00 39.94  ? 281 CYS A C   1 
ATOM 1990 O O   . CYS A 1 281 ? 98.866  93.780  84.469  1.00 39.94  ? 281 CYS A O   1 
ATOM 1991 C CB  . CYS A 1 281 ? 97.739  94.865  87.372  1.00 39.94  ? 281 CYS A CB  1 
ATOM 1992 S SG  . CYS A 1 281 ? 96.752  94.136  88.693  1.00 39.94  ? 281 CYS A SG  1 
ATOM 1993 N N   . LEU A 1 282 ? 100.122 95.431  85.349  1.00 38.91  ? 282 LEU A N   1 
ATOM 1994 C CA  . LEU A 1 282 ? 100.618 95.857  84.044  1.00 38.91  ? 282 LEU A CA  1 
ATOM 1995 C C   . LEU A 1 282 ? 101.481 94.778  83.398  1.00 38.91  ? 282 LEU A C   1 
ATOM 1996 O O   . LEU A 1 282 ? 101.415 94.571  82.181  1.00 38.91  ? 282 LEU A O   1 
ATOM 1997 C CB  . LEU A 1 282 ? 101.397 97.163  84.190  1.00 38.91  ? 282 LEU A CB  1 
ATOM 1998 C CG  . LEU A 1 282 ? 101.941 97.799  82.913  1.00 38.91  ? 282 LEU A CG  1 
ATOM 1999 C CD1 . LEU A 1 282 ? 100.801 98.182  81.990  1.00 38.91  ? 282 LEU A CD1 1 
ATOM 2000 C CD2 . LEU A 1 282 ? 102.788 99.012  83.251  1.00 38.91  ? 282 LEU A CD2 1 
ATOM 2001 N N   . VAL A 1 283 ? 102.297 94.085  84.194  1.00 38.38  ? 283 VAL A N   1 
ATOM 2002 C CA  . VAL A 1 283 ? 103.117 93.002  83.655  1.00 38.38  ? 283 VAL A CA  1 
ATOM 2003 C C   . VAL A 1 283 ? 102.256 91.806  83.259  1.00 38.38  ? 283 VAL A C   1 
ATOM 2004 O O   . VAL A 1 283 ? 102.483 91.193  82.210  1.00 38.38  ? 283 VAL A O   1 
ATOM 2005 C CB  . VAL A 1 283 ? 104.212 92.611  84.668  1.00 38.38  ? 283 VAL A CB  1 
ATOM 2006 C CG1 . VAL A 1 283 ? 104.932 91.348  84.230  1.00 38.38  ? 283 VAL A CG1 1 
ATOM 2007 C CG2 . VAL A 1 283 ? 105.212 93.742  84.820  1.00 38.38  ? 283 VAL A CG2 1 
ATOM 2008 N N   . MET A 1 284 ? 101.248 91.466  84.067  1.00 37.13  ? 284 MET A N   1 
ATOM 2009 C CA  . MET A 1 284 ? 100.387 90.327  83.764  1.00 37.13  ? 284 MET A CA  1 
ATOM 2010 C C   . MET A 1 284 ? 99.480  90.601  82.573  1.00 37.13  ? 284 MET A C   1 
ATOM 2011 O O   . MET A 1 284 ? 99.019  89.660  81.919  1.00 37.13  ? 284 MET A O   1 
ATOM 2012 C CB  . MET A 1 284 ? 99.548  89.960  84.988  1.00 37.13  ? 284 MET A CB  1 
ATOM 2013 C CG  . MET A 1 284 ? 100.256 89.080  86.013  1.00 37.13  ? 284 MET A CG  1 
ATOM 2014 S SD  . MET A 1 284 ? 101.152 87.668  85.332  1.00 37.13  ? 284 MET A SD  1 
ATOM 2015 C CE  . MET A 1 284 ? 99.852  86.800  84.455  1.00 37.13  ? 284 MET A CE  1 
ATOM 2016 N N   . ALA A 1 285 ? 99.196  91.873  82.290  1.00 34.69  ? 285 ALA A N   1 
ATOM 2017 C CA  . ALA A 1 285 ? 98.410  92.200  81.107  1.00 34.69  ? 285 ALA A CA  1 
ATOM 2018 C C   . ALA A 1 285 ? 99.187  91.941  79.823  1.00 34.69  ? 285 ALA A C   1 
ATOM 2019 O O   . ALA A 1 285 ? 98.576  91.734  78.770  1.00 34.69  ? 285 ALA A O   1 
ATOM 2020 C CB  . ALA A 1 285 ? 97.953  93.656  81.164  1.00 34.69  ? 285 ALA A CB  1 
ATOM 2021 N N   . ILE A 1 286 ? 100.523 91.950  79.891  1.00 33.77  ? 286 ILE A N   1 
ATOM 2022 C CA  . ILE A 1 286 ? 101.332 91.796  78.677  1.00 33.77  ? 286 ILE A CA  1 
ATOM 2023 C C   . ILE A 1 286 ? 101.133 90.441  77.998  1.00 33.77  ? 286 ILE A C   1 
ATOM 2024 O O   . ILE A 1 286 ? 100.928 90.419  76.774  1.00 33.77  ? 286 ILE A O   1 
ATOM 2025 C CB  . ILE A 1 286 ? 102.808 92.110  78.983  1.00 33.77  ? 286 ILE A CB  1 
ATOM 2026 C CG1 . ILE A 1 286 ? 103.000 93.610  79.198  1.00 33.77  ? 286 ILE A CG1 1 
ATOM 2027 C CG2 . ILE A 1 286 ? 103.714 91.623  77.865  1.00 33.77  ? 286 ILE A CG2 1 
ATOM 2028 C CD1 . ILE A 1 286 ? 104.335 93.970  79.806  1.00 33.77  ? 286 ILE A CD1 1 
ATOM 2029 N N   . PRO A 1 287 ? 101.184 89.291  78.699  1.00 29.72  ? 287 PRO A N   1 
ATOM 2030 C CA  . PRO A 1 287 ? 100.839 88.039  78.001  1.00 29.72  ? 287 PRO A CA  1 
ATOM 2031 C C   . PRO A 1 287 ? 99.405  87.994  77.506  1.00 29.72  ? 287 PRO A C   1 
ATOM 2032 O O   . PRO A 1 287 ? 99.151  87.416  76.447  1.00 29.72  ? 287 PRO A O   1 
ATOM 2033 C CB  . PRO A 1 287 ? 101.111 86.954  79.053  1.00 29.72  ? 287 PRO A CB  1 
ATOM 2034 C CG  . PRO A 1 287 ? 101.121 87.648  80.338  1.00 29.72  ? 287 PRO A CG  1 
ATOM 2035 C CD  . PRO A 1 287 ? 101.660 89.002  80.065  1.00 29.72  ? 287 PRO A CD  1 
ATOM 2036 N N   . ALA A 1 288 ? 98.459  88.593  78.234  1.00 29.87  ? 288 ALA A N   1 
ATOM 2037 C CA  . ALA A 1 288 ? 97.070  88.610  77.781  1.00 29.87  ? 288 ALA A CA  1 
ATOM 2038 C C   . ALA A 1 288 ? 96.916  89.431  76.504  1.00 29.87  ? 288 ALA A C   1 
ATOM 2039 O O   . ALA A 1 288 ? 96.236  89.012  75.558  1.00 29.87  ? 288 ALA A O   1 
ATOM 2040 C CB  . ALA A 1 288 ? 96.169  89.153  78.888  1.00 29.87  ? 288 ALA A CB  1 
ATOM 2041 N N   . ILE A 1 289 ? 97.556  90.603  76.459  1.00 28.78  ? 289 ILE A N   1 
ATOM 2042 C CA  . ILE A 1 289 ? 97.546  91.428  75.253  1.00 28.78  ? 289 ILE A CA  1 
ATOM 2043 C C   . ILE A 1 289 ? 98.233  90.700  74.106  1.00 28.78  ? 289 ILE A C   1 
ATOM 2044 O O   . ILE A 1 289 ? 97.783  90.757  72.956  1.00 28.78  ? 289 ILE A O   1 
ATOM 2045 C CB  . ILE A 1 289 ? 98.201  92.794  75.542  1.00 28.78  ? 289 ILE A CB  1 
ATOM 2046 C CG1 . ILE A 1 289 ? 97.318  93.624  76.470  1.00 28.78  ? 289 ILE A CG1 1 
ATOM 2047 C CG2 . ILE A 1 289 ? 98.465  93.568  74.259  1.00 28.78  ? 289 ILE A CG2 1 
ATOM 2048 C CD1 . ILE A 1 289 ? 98.018  94.821  77.054  1.00 28.78  ? 289 ILE A CD1 1 
ATOM 2049 N N   . LEU A 1 290 ? 99.322  89.986  74.403  1.00 30.74  ? 290 LEU A N   1 
ATOM 2050 C CA  . LEU A 1 290 ? 100.037 89.244  73.368  1.00 30.74  ? 290 LEU A CA  1 
ATOM 2051 C C   . LEU A 1 290 ? 99.191  88.106  72.808  1.00 30.74  ? 290 LEU A C   1 
ATOM 2052 O O   . LEU A 1 290 ? 99.195  87.866  71.598  1.00 30.74  ? 290 LEU A O   1 
ATOM 2053 C CB  . LEU A 1 290 ? 101.354 88.709  73.927  1.00 30.74  ? 290 LEU A CB  1 
ATOM 2054 C CG  . LEU A 1 290 ? 102.525 89.692  73.967  1.00 30.74  ? 290 LEU A CG  1 
ATOM 2055 C CD1 . LEU A 1 290 ? 103.696 89.104  74.733  1.00 30.74  ? 290 LEU A CD1 1 
ATOM 2056 C CD2 . LEU A 1 290 ? 102.942 90.086  72.570  1.00 30.74  ? 290 LEU A CD2 1 
ATOM 2057 N N   . ILE A 1 291 ? 98.462  87.394  73.669  1.00 30.89  ? 291 ILE A N   1 
ATOM 2058 C CA  . ILE A 1 291 ? 97.596  86.312  73.207  1.00 30.89  ? 291 ILE A CA  1 
ATOM 2059 C C   . ILE A 1 291 ? 96.425  86.867  72.404  1.00 30.89  ? 291 ILE A C   1 
ATOM 2060 O O   . ILE A 1 291 ? 96.006  86.272  71.404  1.00 30.89  ? 291 ILE A O   1 
ATOM 2061 C CB  . ILE A 1 291 ? 97.128  85.458  74.401  1.00 30.89  ? 291 ILE A CB  1 
ATOM 2062 C CG1 . ILE A 1 291 ? 98.316  84.724  75.021  1.00 30.89  ? 291 ILE A CG1 1 
ATOM 2063 C CG2 . ILE A 1 291 ? 96.073  84.447  73.982  1.00 30.89  ? 291 ILE A CG2 1 
ATOM 2064 C CD1 . ILE A 1 291 ? 98.077  84.282  76.435  1.00 30.89  ? 291 ILE A CD1 1 
ATOM 2065 N N   . GLY A 1 292 ? 95.884  88.017  72.817  1.00 32.42  ? 292 GLY A N   1 
ATOM 2066 C CA  . GLY A 1 292 ? 94.872  88.677  72.004  1.00 32.42  ? 292 GLY A CA  1 
ATOM 2067 C C   . GLY A 1 292 ? 95.397  89.086  70.640  1.00 32.42  ? 292 GLY A C   1 
ATOM 2068 O O   . GLY A 1 292 ? 94.704  88.950  69.629  1.00 32.42  ? 292 GLY A O   1 
ATOM 2069 N N   . ALA A 1 293 ? 96.639  89.574  70.593  1.00 33.78  ? 293 ALA A N   1 
ATOM 2070 C CA  . ALA A 1 293 ? 97.272  89.922  69.325  1.00 33.78  ? 293 ALA A CA  1 
ATOM 2071 C C   . ALA A 1 293 ? 97.494  88.693  68.451  1.00 33.78  ? 293 ALA A C   1 
ATOM 2072 O O   . ALA A 1 293 ? 97.322  88.757  67.230  1.00 33.78  ? 293 ALA A O   1 
ATOM 2073 C CB  . ALA A 1 293 ? 98.595  90.636  69.584  1.00 33.78  ? 293 ALA A CB  1 
ATOM 2074 N N   . ILE A 1 294 ? 97.903  87.575  69.054  1.00 33.40  ? 294 ILE A N   1 
ATOM 2075 C CA  . ILE A 1 294 ? 98.088  86.336  68.302  1.00 33.40  ? 294 ILE A CA  1 
ATOM 2076 C C   . ILE A 1 294 ? 96.756  85.841  67.751  1.00 33.40  ? 294 ILE A C   1 
ATOM 2077 O O   . ILE A 1 294 ? 96.671  85.407  66.596  1.00 33.40  ? 294 ILE A O   1 
ATOM 2078 C CB  . ILE A 1 294 ? 98.775  85.271  69.180  1.00 33.40  ? 294 ILE A CB  1 
ATOM 2079 C CG1 . ILE A 1 294 ? 100.225 85.658  69.474  1.00 33.40  ? 294 ILE A CG1 1 
ATOM 2080 C CG2 . ILE A 1 294 ? 98.741  83.909  68.519  1.00 33.40  ? 294 ILE A CG2 1 
ATOM 2081 C CD1 . ILE A 1 294 ? 100.741 85.125  70.795  1.00 33.40  ? 294 ILE A CD1 1 
ATOM 2082 N N   . GLY A 1 295 ? 95.698  85.905  68.562  1.00 36.69  ? 295 GLY A N   1 
ATOM 2083 C CA  . GLY A 1 295 ? 94.379  85.521  68.084  1.00 36.69  ? 295 GLY A CA  1 
ATOM 2084 C C   . GLY A 1 295 ? 93.882  86.410  66.961  1.00 36.69  ? 295 GLY A C   1 
ATOM 2085 O O   . GLY A 1 295 ? 93.249  85.937  66.015  1.00 36.69  ? 295 GLY A O   1 
ATOM 2086 N N   . ALA A 1 296 ? 94.164  87.712  67.050  1.00 36.66  ? 296 ALA A N   1 
ATOM 2087 C CA  . ALA A 1 296 ? 93.858  88.620  65.952  1.00 36.66  ? 296 ALA A CA  1 
ATOM 2088 C C   . ALA A 1 296 ? 94.765  88.400  64.750  1.00 36.66  ? 296 ALA A C   1 
ATOM 2089 O O   . ALA A 1 296 ? 94.428  88.839  63.646  1.00 36.66  ? 296 ALA A O   1 
ATOM 2090 C CB  . ALA A 1 296 ? 93.967  90.068  66.427  1.00 36.66  ? 296 ALA A CB  1 
ATOM 2091 N N   . SER A 1 297 ? 95.907  87.739  64.940  1.00 39.24  ? 297 SER A N   1 
ATOM 2092 C CA  . SER A 1 297 ? 96.863  87.480  63.873  1.00 39.24  ? 297 SER A CA  1 
ATOM 2093 C C   . SER A 1 297 ? 96.798  86.057  63.336  1.00 39.24  ? 297 SER A C   1 
ATOM 2094 O O   . SER A 1 297 ? 97.520  85.739  62.387  1.00 39.24  ? 297 SER A O   1 
ATOM 2095 C CB  . SER A 1 297 ? 98.286  87.759  64.369  1.00 39.24  ? 297 SER A CB  1 
ATOM 2096 O OG  . SER A 1 297 ? 98.458  89.126  64.692  1.00 39.24  ? 297 SER A OG  1 
ATOM 2097 N N   . THR A 1 298 ? 95.960  85.200  63.913  1.00 40.02  ? 298 THR A N   1 
ATOM 2098 C CA  . THR A 1 298 ? 95.965  83.783  63.578  1.00 40.02  ? 298 THR A CA  1 
ATOM 2099 C C   . THR A 1 298 ? 95.120  83.506  62.342  1.00 40.02  ? 298 THR A C   1 
ATOM 2100 O O   . THR A 1 298 ? 94.003  84.012  62.207  1.00 40.02  ? 298 THR A O   1 
ATOM 2101 C CB  . THR A 1 298 ? 95.441  82.959  64.757  1.00 40.02  ? 298 THR A CB  1 
ATOM 2102 O OG1 . THR A 1 298 ? 96.204  83.262  65.931  1.00 40.02  ? 298 THR A OG1 1 
ATOM 2103 C CG2 . THR A 1 298 ? 95.555  81.473  64.471  1.00 40.02  ? 298 THR A CG2 1 
ATOM 2104 N N   . ASP A 1 299 ? 95.666  82.699  61.434  1.00 46.02  ? 299 ASP A N   1 
ATOM 2105 C CA  . ASP A 1 299 ? 94.909  82.142  60.316  1.00 46.02  ? 299 ASP A CA  1 
ATOM 2106 C C   . ASP A 1 299 ? 94.285  80.845  60.813  1.00 46.02  ? 299 ASP A C   1 
ATOM 2107 O O   . ASP A 1 299 ? 94.939  79.800  60.845  1.00 46.02  ? 299 ASP A O   1 
ATOM 2108 C CB  . ASP A 1 299 ? 95.813  81.908  59.112  1.00 46.02  ? 299 ASP A CB  1 
ATOM 2109 C CG  . ASP A 1 299 ? 95.038  81.614  57.841  1.00 46.02  ? 299 ASP A CG  1 
ATOM 2110 O OD1 . ASP A 1 299 ? 93.792  81.546  57.894  1.00 46.02  ? 299 ASP A OD1 1 
ATOM 2111 O OD2 . ASP A 1 299 ? 95.679  81.450  56.783  1.00 46.02  ? 299 ASP A OD2 1 
ATOM 2112 N N   . TRP A 1 300 ? 93.009  80.910  61.202  1.00 41.41  ? 300 TRP A N   1 
ATOM 2113 C CA  . TRP A 1 300 ? 92.388  79.788  61.899  1.00 41.41  ? 300 TRP A CA  1 
ATOM 2114 C C   . TRP A 1 300 ? 92.106  78.614  60.969  1.00 41.41  ? 300 TRP A C   1 
ATOM 2115 O O   . TRP A 1 300 ? 91.875  77.498  61.443  1.00 41.41  ? 300 TRP A O   1 
ATOM 2116 C CB  . TRP A 1 300 ? 91.104  80.249  62.585  1.00 41.41  ? 300 TRP A CB  1 
ATOM 2117 C CG  . TRP A 1 300 ? 91.361  81.199  63.707  1.00 41.41  ? 300 TRP A CG  1 
ATOM 2118 C CD1 . TRP A 1 300 ? 91.149  82.544  63.704  1.00 41.41  ? 300 TRP A CD1 1 
ATOM 2119 C CD2 . TRP A 1 300 ? 91.899  80.881  64.994  1.00 41.41  ? 300 TRP A CD2 1 
ATOM 2120 N NE1 . TRP A 1 300 ? 91.510  83.084  64.913  1.00 41.41  ? 300 TRP A NE1 1 
ATOM 2121 C CE2 . TRP A 1 300 ? 91.976  82.082  65.722  1.00 41.41  ? 300 TRP A CE2 1 
ATOM 2122 C CE3 . TRP A 1 300 ? 92.319  79.696  65.602  1.00 41.41  ? 300 TRP A CE3 1 
ATOM 2123 C CZ2 . TRP A 1 300 ? 92.456  82.133  67.026  1.00 41.41  ? 300 TRP A CZ2 1 
ATOM 2124 C CZ3 . TRP A 1 300 ? 92.796  79.749  66.895  1.00 41.41  ? 300 TRP A CZ3 1 
ATOM 2125 C CH2 . TRP A 1 300 ? 92.860  80.959  67.594  1.00 41.41  ? 300 TRP A CH2 1 
ATOM 2126 N N   . ASN A 1 301 ? 92.112  78.841  59.654  1.00 48.72  ? 301 ASN A N   1 
ATOM 2127 C CA  . ASN A 1 301 ? 91.961  77.731  58.719  1.00 48.72  ? 301 ASN A CA  1 
ATOM 2128 C C   . ASN A 1 301 ? 93.150  76.781  58.785  1.00 48.72  ? 301 ASN A C   1 
ATOM 2129 O O   . ASN A 1 301 ? 92.997  75.576  58.555  1.00 48.72  ? 301 ASN A O   1 
ATOM 2130 C CB  . ASN A 1 301 ? 91.782  78.261  57.297  1.00 48.72  ? 301 ASN A CB  1 
ATOM 2131 C CG  . ASN A 1 301 ? 91.301  77.195  56.333  1.00 48.72  ? 301 ASN A CG  1 
ATOM 2132 O OD1 . ASN A 1 301 ? 90.792  76.153  56.745  1.00 48.72  ? 301 ASN A OD1 1 
ATOM 2133 N ND2 . ASN A 1 301 ? 91.460  77.451  55.041  1.00 48.72  ? 301 ASN A ND2 1 
ATOM 2134 N N   . GLN A 1 302 ? 94.339  77.301  59.094  1.00 51.55  ? 302 GLN A N   1 
ATOM 2135 C CA  . GLN A 1 302 ? 95.520  76.455  59.225  1.00 51.55  ? 302 GLN A CA  1 
ATOM 2136 C C   . GLN A 1 302 ? 95.528  75.675  60.534  1.00 51.55  ? 302 GLN A C   1 
ATOM 2137 O O   . GLN A 1 302 ? 96.221  74.657  60.637  1.00 51.55  ? 302 GLN A O   1 
ATOM 2138 C CB  . GLN A 1 302 ? 96.787  77.304  59.115  1.00 51.55  ? 302 GLN A CB  1 
ATOM 2139 C CG  . GLN A 1 302 ? 97.021  77.889  57.733  1.00 51.55  ? 302 GLN A CG  1 
ATOM 2140 C CD  . GLN A 1 302 ? 98.389  78.526  57.593  1.00 51.55  ? 302 GLN A CD  1 
ATOM 2141 O OE1 . GLN A 1 302 ? 99.414  77.858  57.723  1.00 51.55  ? 302 GLN A OE1 1 
ATOM 2142 N NE2 . GLN A 1 302 ? 98.411  79.827  57.329  1.00 51.55  ? 302 GLN A NE2 1 
ATOM 2143 N N   . THR A 1 303 ? 94.779  76.129  61.534  1.00 47.03  ? 303 THR A N   1 
ATOM 2144 C CA  . THR A 1 303 ? 94.776  75.486  62.838  1.00 47.03  ? 303 THR A CA  1 
ATOM 2145 C C   . THR A 1 303 ? 93.729  74.376  62.893  1.00 47.03  ? 303 THR A C   1 
ATOM 2146 O O   . THR A 1 303 ? 92.899  74.215  61.994  1.00 47.03  ? 303 THR A O   1 
ATOM 2147 C CB  . THR A 1 303 ? 94.512  76.509  63.939  1.00 47.03  ? 303 THR A CB  1 
ATOM 2148 O OG1 . THR A 1 303 ? 93.106  76.758  64.031  1.00 47.03  ? 303 THR A OG1 1 
ATOM 2149 C CG2 . THR A 1 303 ? 95.214  77.809  63.616  1.00 47.03  ? 303 THR A CG2 1 
ATOM 2150 N N   . ALA A 1 304 ? 93.778  73.597  63.976  1.00 45.87  ? 304 ALA A N   1 
ATOM 2151 C CA  . ALA A 1 304 ? 92.796  72.539  64.181  1.00 45.87  ? 304 ALA A CA  1 
ATOM 2152 C C   . ALA A 1 304 ? 91.432  73.086  64.577  1.00 45.87  ? 304 ALA A C   1 
ATOM 2153 O O   . ALA A 1 304 ? 90.445  72.344  64.528  1.00 45.87  ? 304 ALA A O   1 
ATOM 2154 C CB  . ALA A 1 304 ? 93.291  71.556  65.242  1.00 45.87  ? 304 ALA A CB  1 
ATOM 2155 N N   . TYR A 1 305 ? 91.360  74.356  64.982  1.00 41.41  ? 305 TYR A N   1 
ATOM 2156 C CA  . TYR A 1 305 ? 90.072  74.988  65.251  1.00 41.41  ? 305 TYR A CA  1 
ATOM 2157 C C   . TYR A 1 305 ? 89.232  75.069  63.984  1.00 41.41  ? 305 TYR A C   1 
ATOM 2158 O O   . TYR A 1 305 ? 88.019  74.828  64.010  1.00 41.41  ? 305 TYR A O   1 
ATOM 2159 C CB  . TYR A 1 305 ? 90.291  76.379  65.845  1.00 41.41  ? 305 TYR A CB  1 
ATOM 2160 C CG  . TYR A 1 305 ? 89.061  76.990  66.471  1.00 41.41  ? 305 TYR A CG  1 
ATOM 2161 C CD1 . TYR A 1 305 ? 88.727  76.723  67.789  1.00 41.41  ? 305 TYR A CD1 1 
ATOM 2162 C CD2 . TYR A 1 305 ? 88.240  77.843  65.746  1.00 41.41  ? 305 TYR A CD2 1 
ATOM 2163 C CE1 . TYR A 1 305 ? 87.606  77.281  68.367  1.00 41.41  ? 305 TYR A CE1 1 
ATOM 2164 C CE2 . TYR A 1 305 ? 87.116  78.406  66.316  1.00 41.41  ? 305 TYR A CE2 1 
ATOM 2165 C CZ  . TYR A 1 305 ? 86.805  78.122  67.627  1.00 41.41  ? 305 TYR A CZ  1 
ATOM 2166 O OH  . TYR A 1 305 ? 85.688  78.679  68.202  1.00 41.41  ? 305 TYR A OH  1 
ATOM 2167 N N   . GLY A 1 306 ? 89.862  75.407  62.862  1.00 45.07  ? 306 GLY A N   1 
ATOM 2168 C CA  . GLY A 1 306 ? 89.176  75.451  61.590  1.00 45.07  ? 306 GLY A CA  1 
ATOM 2169 C C   . GLY A 1 306 ? 88.341  76.703  61.415  1.00 45.07  ? 306 GLY A C   1 
ATOM 2170 O O   . GLY A 1 306 ? 88.311  77.606  62.252  1.00 45.07  ? 306 GLY A O   1 
ATOM 2171 N N   . LEU A 1 307 ? 87.640  76.746  60.285  1.00 51.49  ? 307 LEU A N   1 
ATOM 2172 C CA  . LEU A 1 307 ? 86.756  77.851  59.963  1.00 51.49  ? 307 LEU A CA  1 
ATOM 2173 C C   . LEU A 1 307 ? 85.309  77.466  60.249  1.00 51.49  ? 307 LEU A C   1 
ATOM 2174 O O   . LEU A 1 307 ? 84.931  76.307  60.046  1.00 51.49  ? 307 LEU A O   1 
ATOM 2175 C CB  . LEU A 1 307 ? 86.898  78.260  58.492  1.00 51.49  ? 307 LEU A CB  1 
ATOM 2176 C CG  . LEU A 1 307 ? 88.020  79.257  58.193  1.00 51.49  ? 307 LEU A CG  1 
ATOM 2177 C CD1 . LEU A 1 307 ? 88.080  79.580  56.708  1.00 51.49  ? 307 LEU A CD1 1 
ATOM 2178 C CD2 . LEU A 1 307 ? 87.850  80.524  59.014  1.00 51.49  ? 307 LEU A CD2 1 
ATOM 2179 N N   . PRO A 1 308 ? 84.467  78.404  60.719  1.00 50.44  ? 308 PRO A N   1 
ATOM 2180 C CA  . PRO A 1 308 ? 84.723  79.829  60.970  1.00 50.44  ? 308 PRO A CA  1 
ATOM 2181 C C   . PRO A 1 308 ? 85.581  80.123  62.202  1.00 50.44  ? 308 PRO A C   1 
ATOM 2182 O O   . PRO A 1 308 ? 85.687  79.296  63.106  1.00 50.44  ? 308 PRO A O   1 
ATOM 2183 C CB  . PRO A 1 308 ? 83.316  80.399  61.159  1.00 50.44  ? 308 PRO A CB  1 
ATOM 2184 C CG  . PRO A 1 308 ? 82.536  79.261  61.694  1.00 50.44  ? 308 PRO A CG  1 
ATOM 2185 C CD  . PRO A 1 308 ? 83.059  78.056  60.974  1.00 50.44  ? 308 PRO A CD  1 
ATOM 2186 N N   . ASP A 1 309 ? 86.180  81.312  62.217  1.00 48.40  ? 309 ASP A N   1 
ATOM 2187 C CA  . ASP A 1 309 ? 87.049  81.784  63.288  1.00 48.40  ? 309 ASP A CA  1 
ATOM 2188 C C   . ASP A 1 309 ? 86.228  82.064  64.548  1.00 48.40  ? 309 ASP A C   1 
ATOM 2189 O O   . ASP A 1 309 ? 84.995  82.116  64.464  1.00 48.40  ? 309 ASP A O   1 
ATOM 2190 C CB  . ASP A 1 309 ? 87.847  83.004  62.797  1.00 48.40  ? 309 ASP A CB  1 
ATOM 2191 C CG  . ASP A 1 309 ? 86.975  84.192  62.429  1.00 48.40  ? 309 ASP A CG  1 
ATOM 2192 O OD1 . ASP A 1 309 ? 85.736  84.103  62.497  1.00 48.40  ? 309 ASP A OD1 1 
ATOM 2193 O OD2 . ASP A 1 309 ? 87.549  85.238  62.061  1.00 48.40  ? 309 ASP A OD2 1 
ATOM 2194 N N   . PRO A 1 310 ? 86.854  82.195  65.731  1.00 42.57  ? 310 PRO A N   1 
ATOM 2195 C CA  . PRO A 1 310 ? 86.059  82.338  66.966  1.00 42.57  ? 310 PRO A CA  1 
ATOM 2196 C C   . PRO A 1 310 ? 85.099  83.517  66.990  1.00 42.57  ? 310 PRO A C   1 
ATOM 2197 O O   . PRO A 1 310 ? 84.054  83.428  67.646  1.00 42.57  ? 310 PRO A O   1 
ATOM 2198 C CB  . PRO A 1 310 ? 87.139  82.473  68.046  1.00 42.57  ? 310 PRO A CB  1 
ATOM 2199 C CG  . PRO A 1 310 ? 88.257  81.677  67.528  1.00 42.57  ? 310 PRO A CG  1 
ATOM 2200 C CD  . PRO A 1 310 ? 88.270  81.922  66.046  1.00 42.57  ? 310 PRO A CD  1 
ATOM 2201 N N   . LYS A 1 311 ? 85.411  84.623  66.312  1.00 46.41  ? 311 LYS A N   1 
ATOM 2202 C CA  . LYS A 1 311 ? 84.518  85.777  66.379  1.00 46.41  ? 311 LYS A CA  1 
ATOM 2203 C C   . LYS A 1 311 ? 83.253  85.555  65.553  1.00 46.41  ? 311 LYS A C   1 
ATOM 2204 O O   . LYS A 1 311 ? 82.182  86.062  65.906  1.00 46.41  ? 311 LYS A O   1 
ATOM 2205 C CB  . LYS A 1 311 ? 85.254  87.049  65.951  1.00 46.41  ? 311 LYS A CB  1 
ATOM 2206 C CG  . LYS A 1 311 ? 85.600  87.159  64.480  1.00 46.41  ? 311 LYS A CG  1 
ATOM 2207 C CD  . LYS A 1 311 ? 86.349  88.451  64.205  1.00 46.41  ? 311 LYS A CD  1 
ATOM 2208 C CE  . LYS A 1 311 ? 87.071  88.403  62.873  1.00 46.41  ? 311 LYS A CE  1 
ATOM 2209 N NZ  . LYS A 1 311 ? 86.219  87.819  61.803  1.00 46.41  ? 311 LYS A NZ  1 
ATOM 2210 N N   . THR A 1 312 ? 83.349  84.798  64.456  1.00 48.90  ? 312 THR A N   1 
ATOM 2211 C CA  . THR A 1 312 ? 82.152  84.451  63.694  1.00 48.90  ? 312 THR A CA  1 
ATOM 2212 C C   . THR A 1 312 ? 81.312  83.417  64.432  1.00 48.90  ? 312 THR A C   1 
ATOM 2213 O O   . THR A 1 312 ? 80.077  83.450  64.365  1.00 48.90  ? 312 THR A O   1 
ATOM 2214 C CB  . THR A 1 312 ? 82.541  83.935  62.307  1.00 48.90  ? 312 THR A CB  1 
ATOM 2215 O OG1 . THR A 1 312 ? 83.368  84.906  61.654  1.00 48.90  ? 312 THR A OG1 1 
ATOM 2216 C CG2 . THR A 1 312 ? 81.310  83.690  61.449  1.00 48.90  ? 312 THR A CG2 1 
ATOM 2217 N N   . THR A 1 313 ? 81.960  82.519  65.168  1.00 48.24  ? 313 THR A N   1 
ATOM 2218 C CA  . THR A 1 313 ? 81.310  81.453  65.918  1.00 48.24  ? 313 THR A CA  1 
ATOM 2219 C C   . THR A 1 313 ? 80.647  81.990  67.193  1.00 48.24  ? 313 THR A C   1 
ATOM 2220 O O   . THR A 1 313 ? 79.963  81.240  67.899  1.00 48.24  ? 313 THR A O   1 
ATOM 2221 C CB  . THR A 1 313 ? 82.373  80.366  66.210  1.00 48.24  ? 313 THR A CB  1 
ATOM 2222 O OG1 . THR A 1 313 ? 82.889  79.889  64.963  1.00 48.24  ? 313 THR A OG1 1 
ATOM 2223 C CG2 . THR A 1 313 ? 81.813  79.130  66.908  1.00 48.24  ? 313 THR A CG2 1 
ATOM 2224 N N   . GLU A 1 314 ? 80.758  83.302  67.438  1.00 49.73  ? 314 GLU A N   1 
ATOM 2225 C CA  . GLU A 1 314 ? 80.341  83.947  68.688  1.00 49.73  ? 314 GLU A CA  1 
ATOM 2226 C C   . GLU A 1 314 ? 81.056  83.327  69.885  1.00 49.73  ? 314 GLU A C   1 
ATOM 2227 O O   . GLU A 1 314 ? 80.470  83.122  70.949  1.00 49.73  ? 314 GLU A O   1 
ATOM 2228 C CB  . GLU A 1 314 ? 78.820  83.915  68.877  1.00 49.73  ? 314 GLU A CB  1 
ATOM 2229 C CG  . GLU A 1 314 ? 78.049  84.756  67.877  1.00 49.73  ? 314 GLU A CG  1 
ATOM 2230 C CD  . GLU A 1 314 ? 76.551  84.683  68.090  1.00 49.73  ? 314 GLU A CD  1 
ATOM 2231 O OE1 . GLU A 1 314 ? 76.108  83.876  68.935  1.00 49.73  ? 314 GLU A OE1 1 
ATOM 2232 O OE2 . GLU A 1 314 ? 75.817  85.437  67.419  1.00 49.73  ? 314 GLU A OE2 1 
ATOM 2233 N N   . GLU A 1 315 ? 82.339  83.033  69.702  1.00 45.68  ? 315 GLU A N   1 
ATOM 2234 C CA  . GLU A 1 315 ? 83.209  82.505  70.742  1.00 45.68  ? 315 GLU A CA  1 
ATOM 2235 C C   . GLU A 1 315 ? 84.439  83.386  70.893  1.00 45.68  ? 315 GLU A C   1 
ATOM 2236 O O   . GLU A 1 315 ? 85.542  82.909  71.169  1.00 45.68  ? 315 GLU A O   1 
ATOM 2237 C CB  . GLU A 1 315 ? 83.604  81.063  70.438  1.00 45.68  ? 315 GLU A CB  1 
ATOM 2238 C CG  . GLU A 1 315 ? 82.564  80.046  70.860  1.00 45.68  ? 315 GLU A CG  1 
ATOM 2239 C CD  . GLU A 1 315 ? 82.820  78.679  70.269  1.00 45.68  ? 315 GLU A CD  1 
ATOM 2240 O OE1 . GLU A 1 315 ? 81.891  77.846  70.272  1.00 45.68  ? 315 GLU A OE1 1 
ATOM 2241 O OE2 . GLU A 1 315 ? 83.953  78.436  69.806  1.00 45.68  ? 315 GLU A OE2 1 
ATOM 2242 N N   . ALA A 1 316 ? 84.263  84.696  70.696  1.00 40.71  ? 316 ALA A N   1 
ATOM 2243 C CA  . ALA A 1 316 ? 85.374  85.629  70.843  1.00 40.71  ? 316 ALA A CA  1 
ATOM 2244 C C   . ALA A 1 316 ? 85.783  85.790  72.301  1.00 40.71  ? 316 ALA A C   1 
ATOM 2245 O O   . ALA A 1 316 ? 86.922  86.178  72.584  1.00 40.71  ? 316 ALA A O   1 
ATOM 2246 C CB  . ALA A 1 316 ? 85.006  86.984  70.240  1.00 40.71  ? 316 ALA A CB  1 
ATOM 2247 N N   . ASP A 1 317 ? 84.876  85.508  73.233  1.00 40.90  ? 317 ASP A N   1 
ATOM 2248 C CA  . ASP A 1 317 ? 85.203  85.529  74.652  1.00 40.90  ? 317 ASP A CA  1 
ATOM 2249 C C   . ASP A 1 317 ? 86.020  84.320  75.090  1.00 40.90  ? 317 ASP A C   1 
ATOM 2250 O O   . ASP A 1 317 ? 86.496  84.296  76.229  1.00 40.90  ? 317 ASP A O   1 
ATOM 2251 C CB  . ASP A 1 317 ? 83.921  85.617  75.483  1.00 40.90  ? 317 ASP A CB  1 
ATOM 2252 C CG  . ASP A 1 317 ? 83.011  84.419  75.286  1.00 40.90  ? 317 ASP A CG  1 
ATOM 2253 O OD1 . ASP A 1 317 ? 82.646  84.129  74.127  1.00 40.90  ? 317 ASP A OD1 1 
ATOM 2254 O OD2 . ASP A 1 317 ? 82.656  83.770  76.291  1.00 40.90  ? 317 ASP A OD2 1 
ATOM 2255 N N   . MET A 1 318 ? 86.189  83.322  74.222  1.00 41.06  ? 318 MET A N   1 
ATOM 2256 C CA  . MET A 1 318 ? 86.959  82.125  74.528  1.00 41.06  ? 318 MET A CA  1 
ATOM 2257 C C   . MET A 1 318 ? 88.336  82.140  73.879  1.00 41.06  ? 318 MET A C   1 
ATOM 2258 O O   . MET A 1 318 ? 88.959  81.082  73.751  1.00 41.06  ? 318 MET A O   1 
ATOM 2259 C CB  . MET A 1 318 ? 86.203  80.875  74.078  1.00 41.06  ? 318 MET A CB  1 
ATOM 2260 C CG  . MET A 1 318 ? 84.823  80.708  74.676  1.00 41.06  ? 318 MET A CG  1 
ATOM 2261 S SD  . MET A 1 318 ? 84.213  79.015  74.547  1.00 41.06  ? 318 MET A SD  1 
ATOM 2262 C CE  . MET A 1 318 ? 85.012  78.454  73.047  1.00 41.06  ? 318 MET A CE  1 
ATOM 2263 N N   . ILE A 1 319 ? 88.821  83.313  73.466  1.00 34.45  ? 319 ILE A N   1 
ATOM 2264 C CA  . ILE A 1 319 ? 90.000  83.376  72.606  1.00 34.45  ? 319 ILE A CA  1 
ATOM 2265 C C   . ILE A 1 319 ? 91.264  82.922  73.333  1.00 34.45  ? 319 ILE A C   1 
ATOM 2266 O O   . ILE A 1 319 ? 92.133  82.286  72.726  1.00 34.45  ? 319 ILE A O   1 
ATOM 2267 C CB  . ILE A 1 319 ? 90.143  84.794  72.011  1.00 34.45  ? 319 ILE A CB  1 
ATOM 2268 C CG1 . ILE A 1 319 ? 91.284  84.842  70.993  1.00 34.45  ? 319 ILE A CG1 1 
ATOM 2269 C CG2 . ILE A 1 319 ? 90.307  85.852  73.097  1.00 34.45  ? 319 ILE A CG2 1 
ATOM 2270 C CD1 . ILE A 1 319 ? 91.060  83.952  69.801  1.00 34.45  ? 319 ILE A CD1 1 
ATOM 2271 N N   . LEU A 1 320 ? 91.400  83.227  74.631  1.00 30.76  ? 320 LEU A N   1 
ATOM 2272 C CA  . LEU A 1 320 ? 92.606  82.807  75.346  1.00 30.76  ? 320 LEU A CA  1 
ATOM 2273 C C   . LEU A 1 320 ? 92.706  81.290  75.493  1.00 30.76  ? 320 LEU A C   1 
ATOM 2274 O O   . LEU A 1 320 ? 93.789  80.744  75.219  1.00 30.76  ? 320 LEU A O   1 
ATOM 2275 C CB  . LEU A 1 320 ? 92.705  83.539  76.690  1.00 30.76  ? 320 LEU A CB  1 
ATOM 2276 C CG  . LEU A 1 320 ? 94.013  83.378  77.468  1.00 30.76  ? 320 LEU A CG  1 
ATOM 2277 C CD1 . LEU A 1 320 ? 94.432  84.699  78.078  1.00 30.76  ? 320 LEU A CD1 1 
ATOM 2278 C CD2 . LEU A 1 320 ? 93.885  82.316  78.548  1.00 30.76  ? 320 LEU A CD2 1 
ATOM 2279 N N   . PRO A 1 321 ? 91.665  80.550  75.924  1.00 34.16  ? 321 PRO A N   1 
ATOM 2280 C CA  . PRO A 1 321 ? 91.785  79.081  75.898  1.00 34.16  ? 321 PRO A CA  1 
ATOM 2281 C C   . PRO A 1 321 ? 91.982  78.499  74.508  1.00 34.16  ? 321 PRO A C   1 
ATOM 2282 O O   . PRO A 1 321 ? 92.627  77.455  74.370  1.00 34.16  ? 321 PRO A O   1 
ATOM 2283 C CB  . PRO A 1 321 ? 90.463  78.616  76.518  1.00 34.16  ? 321 PRO A CB  1 
ATOM 2284 C CG  . PRO A 1 321 ? 90.061  79.717  77.388  1.00 34.16  ? 321 PRO A CG  1 
ATOM 2285 C CD  . PRO A 1 321 ? 90.438  80.950  76.642  1.00 34.16  ? 321 PRO A CD  1 
ATOM 2286 N N   . ILE A 1 322 ? 91.436  79.137  73.473  1.00 34.87  ? 322 ILE A N   1 
ATOM 2287 C CA  . ILE A 1 322 ? 91.545  78.588  72.124  1.00 34.87  ? 322 ILE A CA  1 
ATOM 2288 C C   . ILE A 1 322 ? 92.978  78.698  71.608  1.00 34.87  ? 322 ILE A C   1 
ATOM 2289 O O   . ILE A 1 322 ? 93.503  77.761  70.995  1.00 34.87  ? 322 ILE A O   1 
ATOM 2290 C CB  . ILE A 1 322 ? 90.533  79.280  71.193  1.00 34.87  ? 322 ILE A CB  1 
ATOM 2291 C CG1 . ILE A 1 322 ? 89.115  78.809  71.514  1.00 34.87  ? 322 ILE A CG1 1 
ATOM 2292 C CG2 . ILE A 1 322 ? 90.830  78.977  69.746  1.00 34.87  ? 322 ILE A CG2 1 
ATOM 2293 C CD1 . ILE A 1 322 ? 88.036  79.701  70.952  1.00 34.87  ? 322 ILE A CD1 1 
ATOM 2294 N N   . VAL A 1 323 ? 93.638  79.830  71.859  1.00 34.40  ? 323 VAL A N   1 
ATOM 2295 C CA  . VAL A 1 323 ? 95.020  80.002  71.415  1.00 34.40  ? 323 VAL A CA  1 
ATOM 2296 C C   . VAL A 1 323 ? 95.956  79.067  72.175  1.00 34.40  ? 323 VAL A C   1 
ATOM 2297 O O   . VAL A 1 323 ? 96.841  78.439  71.582  1.00 34.40  ? 323 VAL A O   1 
ATOM 2298 C CB  . VAL A 1 323 ? 95.445  81.476  71.558  1.00 34.40  ? 323 VAL A CB  1 
ATOM 2299 C CG1 . VAL A 1 323 ? 96.925  81.641  71.260  1.00 34.40  ? 323 VAL A CG1 1 
ATOM 2300 C CG2 . VAL A 1 323 ? 94.627  82.353  70.628  1.00 34.40  ? 323 VAL A CG2 1 
ATOM 2301 N N   . LEU A 1 324 ? 95.772  78.948  73.493  1.00 35.21  ? 324 LEU A N   1 
ATOM 2302 C CA  . LEU A 1 324 ? 96.656  78.104  74.293  1.00 35.21  ? 324 LEU A CA  1 
ATOM 2303 C C   . LEU A 1 324 ? 96.473  76.626  73.968  1.00 35.21  ? 324 LEU A C   1 
ATOM 2304 O O   . LEU A 1 324 ? 97.395  75.824  74.159  1.00 35.21  ? 324 LEU A O   1 
ATOM 2305 C CB  . LEU A 1 324 ? 96.428  78.356  75.782  1.00 35.21  ? 324 LEU A CB  1 
ATOM 2306 C CG  . LEU A 1 324 ? 97.311  79.414  76.448  1.00 35.21  ? 324 LEU A CG  1 
ATOM 2307 C CD1 . LEU A 1 324 ? 96.966  80.808  75.977  1.00 35.21  ? 324 LEU A CD1 1 
ATOM 2308 C CD2 . LEU A 1 324 ? 97.199  79.325  77.957  1.00 35.21  ? 324 LEU A CD2 1 
ATOM 2309 N N   . GLN A 1 325 ? 95.292  76.242  73.486  1.00 37.55  ? 325 GLN A N   1 
ATOM 2310 C CA  . GLN A 1 325 ? 95.044  74.837  73.180  1.00 37.55  ? 325 GLN A CA  1 
ATOM 2311 C C   . GLN A 1 325 ? 95.434  74.502  71.746  1.00 37.55  ? 325 GLN A C   1 
ATOM 2312 O O   . GLN A 1 325 ? 96.085  73.482  71.492  1.00 37.55  ? 325 GLN A O   1 
ATOM 2313 C CB  . GLN A 1 325 ? 93.575  74.504  73.430  1.00 37.55  ? 325 GLN A CB  1 
ATOM 2314 C CG  . GLN A 1 325 ? 93.076  73.233  72.765  1.00 37.55  ? 325 GLN A CG  1 
ATOM 2315 C CD  . GLN A 1 325 ? 93.376  71.990  73.575  1.00 37.55  ? 325 GLN A CD  1 
ATOM 2316 O OE1 . GLN A 1 325 ? 93.831  72.072  74.714  1.00 37.55  ? 325 GLN A OE1 1 
ATOM 2317 N NE2 . GLN A 1 325 ? 93.116  70.828  72.992  1.00 37.55  ? 325 GLN A NE2 1 
ATOM 2318 N N   . TYR A 1 326 ? 95.050  75.351  70.792  1.00 39.00  ? 326 TYR A N   1 
ATOM 2319 C CA  . TYR A 1 326 ? 95.179  75.019  69.379  1.00 39.00  ? 326 TYR A CA  1 
ATOM 2320 C C   . TYR A 1 326 ? 96.456  75.536  68.731  1.00 39.00  ? 326 TYR A C   1 
ATOM 2321 O O   . TYR A 1 326 ? 96.802  75.074  67.639  1.00 39.00  ? 326 TYR A O   1 
ATOM 2322 C CB  . TYR A 1 326 ? 93.971  75.554  68.599  1.00 39.00  ? 326 TYR A CB  1 
ATOM 2323 C CG  . TYR A 1 326 ? 92.679  74.836  68.917  1.00 39.00  ? 326 TYR A CG  1 
ATOM 2324 C CD1 . TYR A 1 326 ? 92.311  73.689  68.228  1.00 39.00  ? 326 TYR A CD1 1 
ATOM 2325 C CD2 . TYR A 1 326 ? 91.832  75.301  69.914  1.00 39.00  ? 326 TYR A CD2 1 
ATOM 2326 C CE1 . TYR A 1 326 ? 91.133  73.029  68.520  1.00 39.00  ? 326 TYR A CE1 1 
ATOM 2327 C CE2 . TYR A 1 326 ? 90.655  74.649  70.213  1.00 39.00  ? 326 TYR A CE2 1 
ATOM 2328 C CZ  . TYR A 1 326 ? 90.310  73.515  69.514  1.00 39.00  ? 326 TYR A CZ  1 
ATOM 2329 O OH  . TYR A 1 326 ? 89.136  72.863  69.811  1.00 39.00  ? 326 TYR A OH  1 
ATOM 2330 N N   . LEU A 1 327 ? 97.159  76.476  69.359  1.00 41.10  ? 327 LEU A N   1 
ATOM 2331 C CA  . LEU A 1 327 ? 98.387  77.030  68.801  1.00 41.10  ? 327 LEU A CA  1 
ATOM 2332 C C   . LEU A 1 327 ? 99.630  76.608  69.574  1.00 41.10  ? 327 LEU A C   1 
ATOM 2333 O O   . LEU A 1 327 ? 100.706 77.170  69.351  1.00 41.10  ? 327 LEU A O   1 
ATOM 2334 C CB  . LEU A 1 327 ? 98.300  78.556  68.741  1.00 41.10  ? 327 LEU A CB  1 
ATOM 2335 C CG  . LEU A 1 327 ? 97.249  79.114  67.784  1.00 41.10  ? 327 LEU A CG  1 
ATOM 2336 C CD1 . LEU A 1 327 ? 97.363  80.614  67.685  1.00 41.10  ? 327 LEU A CD1 1 
ATOM 2337 C CD2 . LEU A 1 327 ? 97.419  78.488  66.422  1.00 41.10  ? 327 LEU A CD2 1 
ATOM 2338 N N   . CYS A 1 328 ? 99.511  75.634  70.466  1.00 41.59  ? 328 CYS A N   1 
ATOM 2339 C CA  . CYS A 1 328 ? 100.607 75.139  71.278  1.00 41.59  ? 328 CYS A CA  1 
ATOM 2340 C C   . CYS A 1 328 ? 100.735 73.631  71.110  1.00 41.59  ? 328 CYS A C   1 
ATOM 2341 O O   . CYS A 1 328 ? 99.761  72.954  70.760  1.00 41.59  ? 328 CYS A O   1 
ATOM 2342 C CB  . CYS A 1 328 ? 100.384 75.483  72.759  1.00 41.59  ? 328 CYS A CB  1 
ATOM 2343 S SG  . CYS A 1 328 ? 100.368 77.251  73.122  1.00 41.59  ? 328 CYS A SG  1 
ATOM 2344 N N   . PRO A 1 329 ? 101.925 73.072  71.332  1.00 45.35  ? 329 PRO A N   1 
ATOM 2345 C CA  . PRO A 1 329 ? 102.079 71.614  71.267  1.00 45.35  ? 329 PRO A CA  1 
ATOM 2346 C C   . PRO A 1 329 ? 101.309 70.914  72.377  1.00 45.35  ? 329 PRO A C   1 
ATOM 2347 O O   . PRO A 1 329 ? 100.857 71.529  73.345  1.00 45.35  ? 329 PRO A O   1 
ATOM 2348 C CB  . PRO A 1 329 ? 103.590 71.404  71.421  1.00 45.35  ? 329 PRO A CB  1 
ATOM 2349 C CG  . PRO A 1 329 ? 104.197 72.706  71.040  1.00 45.35  ? 329 PRO A CG  1 
ATOM 2350 C CD  . PRO A 1 329 ? 103.224 73.751  71.474  1.00 45.35  ? 329 PRO A CD  1 
ATOM 2351 N N   . VAL A 1 330 ? 101.166 69.595  72.211  1.00 47.54  ? 330 VAL A N   1 
ATOM 2352 C CA  . VAL A 1 330 ? 100.281 68.807  73.069  1.00 47.54  ? 330 VAL A CA  1 
ATOM 2353 C C   . VAL A 1 330 ? 100.759 68.837  74.516  1.00 47.54  ? 330 VAL A C   1 
ATOM 2354 O O   . VAL A 1 330 ? 99.966  69.023  75.444  1.00 47.54  ? 330 VAL A O   1 
ATOM 2355 C CB  . VAL A 1 330 ? 100.173 67.365  72.539  1.00 47.54  ? 330 VAL A CB  1 
ATOM 2356 C CG1 . VAL A 1 330 ? 99.357  66.503  73.489  1.00 47.54  ? 330 VAL A CG1 1 
ATOM 2357 C CG2 . VAL A 1 330 ? 99.561  67.361  71.148  1.00 47.54  ? 330 VAL A CG2 1 
ATOM 2358 N N   . TYR A 1 331 ? 102.063 68.657  74.731  1.00 49.07  ? 331 TYR A N   1 
ATOM 2359 C CA  . TYR A 1 331 ? 102.604 68.705  76.087  1.00 49.07  ? 331 TYR A CA  1 
ATOM 2360 C C   . TYR A 1 331 ? 102.546 70.121  76.650  1.00 49.07  ? 331 TYR A C   1 
ATOM 2361 O O   . TYR A 1 331 ? 102.215 70.324  77.827  1.00 49.07  ? 331 TYR A O   1 
ATOM 2362 C CB  . TYR A 1 331 ? 104.038 68.163  76.111  1.00 49.07  ? 331 TYR A CB  1 
ATOM 2363 C CG  . TYR A 1 331 ? 104.989 68.758  75.086  1.00 49.07  ? 331 TYR A CG  1 
ATOM 2364 C CD1 . TYR A 1 331 ? 104.984 68.331  73.761  1.00 49.07  ? 331 TYR A CD1 1 
ATOM 2365 C CD2 . TYR A 1 331 ? 105.909 69.731  75.452  1.00 49.07  ? 331 TYR A CD2 1 
ATOM 2366 C CE1 . TYR A 1 331 ? 105.852 68.871  72.831  1.00 49.07  ? 331 TYR A CE1 1 
ATOM 2367 C CE2 . TYR A 1 331 ? 106.784 70.272  74.529  1.00 49.07  ? 331 TYR A CE2 1 
ATOM 2368 C CZ  . TYR A 1 331 ? 106.750 69.840  73.221  1.00 49.07  ? 331 TYR A CZ  1 
ATOM 2369 O OH  . TYR A 1 331 ? 107.619 70.378  72.301  1.00 49.07  ? 331 TYR A OH  1 
ATOM 2370 N N   . ILE A 1 332 ? 102.855 71.117  75.815  1.00 46.22  ? 332 ILE A N   1 
ATOM 2371 C CA  . ILE A 1 332 ? 102.782 72.510  76.247  1.00 46.22  ? 332 ILE A CA  1 
ATOM 2372 C C   . ILE A 1 332 ? 101.344 72.897  76.567  1.00 46.22  ? 332 ILE A C   1 
ATOM 2373 O O   . ILE A 1 332 ? 101.083 73.578  77.564  1.00 46.22  ? 332 ILE A O   1 
ATOM 2374 C CB  . ILE A 1 332 ? 103.401 73.435  75.183  1.00 46.22  ? 332 ILE A CB  1 
ATOM 2375 C CG1 . ILE A 1 332 ? 104.901 73.179  75.077  1.00 46.22  ? 332 ILE A CG1 1 
ATOM 2376 C CG2 . ILE A 1 332 ? 103.146 74.897  75.514  1.00 46.22  ? 332 ILE A CG2 1 
ATOM 2377 C CD1 . ILE A 1 332 ? 105.662 73.512  76.340  1.00 46.22  ? 332 ILE A CD1 1 
ATOM 2378 N N   . SER A 1 333 ? 100.391 72.476  75.729  1.00 44.56  ? 333 SER A N   1 
ATOM 2379 C CA  . SER A 1 333 ? 98.985  72.715  76.036  1.00 44.56  ? 333 SER A CA  1 
ATOM 2380 C C   . SER A 1 333 ? 98.589  72.037  77.340  1.00 44.56  ? 333 SER A C   1 
ATOM 2381 O O   . SER A 1 333 ? 98.038  72.685  78.234  1.00 44.56  ? 333 SER A O   1 
ATOM 2382 C CB  . SER A 1 333 ? 98.100  72.224  74.892  1.00 44.56  ? 333 SER A CB  1 
ATOM 2383 O OG  . SER A 1 333 ? 98.027  73.180  73.851  1.00 44.56  ? 333 SER A OG  1 
ATOM 2384 N N   . PHE A 1 334 ? 98.950  70.758  77.488  1.00 52.67  ? 334 PHE A N   1 
ATOM 2385 C CA  . PHE A 1 334 ? 98.602  69.957  78.659  1.00 52.67  ? 334 PHE A CA  1 
ATOM 2386 C C   . PHE A 1 334 ? 99.091  70.615  79.943  1.00 52.67  ? 334 PHE A C   1 
ATOM 2387 O O   . PHE A 1 334 ? 98.372  70.657  80.948  1.00 52.67  ? 334 PHE A O   1 
ATOM 2388 C CB  . PHE A 1 334 ? 99.195  68.549  78.482  1.00 52.67  ? 334 PHE A CB  1 
ATOM 2389 C CG  . PHE A 1 334 ? 98.952  67.604  79.636  1.00 52.67  ? 334 PHE A CG  1 
ATOM 2390 C CD1 . PHE A 1 334 ? 99.791  67.584  80.742  1.00 52.67  ? 334 PHE A CD1 1 
ATOM 2391 C CD2 . PHE A 1 334 ? 97.901  66.705  79.590  1.00 52.67  ? 334 PHE A CD2 1 
ATOM 2392 C CE1 . PHE A 1 334 ? 99.568  66.710  81.787  1.00 52.67  ? 334 PHE A CE1 1 
ATOM 2393 C CE2 . PHE A 1 334 ? 97.677  65.824  80.631  1.00 52.67  ? 334 PHE A CE2 1 
ATOM 2394 C CZ  . PHE A 1 334 ? 98.511  65.828  81.730  1.00 52.67  ? 334 PHE A CZ  1 
ATOM 2395 N N   . PHE A 1 335 ? 100.316 71.141  79.928  1.00 53.47  ? 335 PHE A N   1 
ATOM 2396 C CA  . PHE A 1 335 ? 100.829 71.806  81.122  1.00 53.47  ? 335 PHE A CA  1 
ATOM 2397 C C   . PHE A 1 335 ? 100.231 73.199  81.290  1.00 53.47  ? 335 PHE A C   1 
ATOM 2398 O O   . PHE A 1 335 ? 99.560  73.472  82.295  1.00 53.47  ? 335 PHE A O   1 
ATOM 2399 C CB  . PHE A 1 335 ? 102.356 71.881  81.074  1.00 53.47  ? 335 PHE A CB  1 
ATOM 2400 C CG  . PHE A 1 335 ? 103.043 70.660  81.621  1.00 53.47  ? 335 PHE A CG  1 
ATOM 2401 C CD1 . PHE A 1 335 ? 102.756 69.400  81.120  1.00 53.47  ? 335 PHE A CD1 1 
ATOM 2402 C CD2 . PHE A 1 335 ? 103.971 70.773  82.643  1.00 53.47  ? 335 PHE A CD2 1 
ATOM 2403 C CE1 . PHE A 1 335 ? 103.384 68.277  81.623  1.00 53.47  ? 335 PHE A CE1 1 
ATOM 2404 C CE2 . PHE A 1 335 ? 104.603 69.653  83.152  1.00 53.47  ? 335 PHE A CE2 1 
ATOM 2405 C CZ  . PHE A 1 335 ? 104.309 68.403  82.640  1.00 53.47  ? 335 PHE A CZ  1 
ATOM 2406 N N   . GLY A 1 336 ? 100.469 74.090  80.321  1.00 45.68  ? 336 GLY A N   1 
ATOM 2407 C CA  . GLY A 1 336 ? 100.128 75.492  80.503  1.00 45.68  ? 336 GLY A CA  1 
ATOM 2408 C C   . GLY A 1 336 ? 98.636  75.739  80.603  1.00 45.68  ? 336 GLY A C   1 
ATOM 2409 O O   . GLY A 1 336 ? 98.170  76.411  81.525  1.00 45.68  ? 336 GLY A O   1 
ATOM 2410 N N   . LEU A 1 337 ? 97.863  75.206  79.659  1.00 44.60  ? 337 LEU A N   1 
ATOM 2411 C CA  . LEU A 1 337 ? 96.414  75.309  79.714  1.00 44.60  ? 337 LEU A CA  1 
ATOM 2412 C C   . LEU A 1 337 ? 95.934  74.105  80.510  1.00 44.60  ? 337 LEU A C   1 
ATOM 2413 O O   . LEU A 1 337 ? 95.826  72.996  79.978  1.00 44.60  ? 337 LEU A O   1 
ATOM 2414 C CB  . LEU A 1 337 ? 95.803  75.353  78.317  1.00 44.60  ? 337 LEU A CB  1 
ATOM 2415 C CG  . LEU A 1 337 ? 94.362  75.850  78.280  1.00 44.60  ? 337 LEU A CG  1 
ATOM 2416 C CD1 . LEU A 1 337 ? 94.280  77.255  78.842  1.00 44.60  ? 337 LEU A CD1 1 
ATOM 2417 C CD2 . LEU A 1 337 ? 93.874  75.841  76.858  1.00 44.60  ? 337 LEU A CD2 1 
ATOM 2418 N N   . GLY A 1 338 ? 95.639  74.338  81.778  1.00 44.19  ? 338 GLY A N   1 
ATOM 2419 C CA  . GLY A 1 338 ? 95.398  73.297  82.751  1.00 44.19  ? 338 GLY A CA  1 
ATOM 2420 C C   . GLY A 1 338 ? 96.063  73.688  84.049  1.00 44.19  ? 338 GLY A C   1 
ATOM 2421 O O   . GLY A 1 338 ? 95.430  73.608  85.103  1.00 44.19  ? 338 GLY A O   1 
ATOM 2422 N N   . ALA A 1 339 ? 97.265  74.267  83.979  1.00 43.85  ? 339 ALA A N   1 
ATOM 2423 C CA  . ALA A 1 339 ? 97.746  75.049  85.111  1.00 43.85  ? 339 ALA A CA  1 
ATOM 2424 C C   . ALA A 1 339 ? 96.926  76.322  85.247  1.00 43.85  ? 339 ALA A C   1 
ATOM 2425 O O   . ALA A 1 339 ? 96.512  76.699  86.352  1.00 43.85  ? 339 ALA A O   1 
ATOM 2426 C CB  . ALA A 1 339 ? 99.229  75.372  84.940  1.00 43.85  ? 339 ALA A CB  1 
ATOM 2427 N N   . VAL A 1 340 ? 96.650  76.972  84.114  1.00 43.79  ? 340 VAL A N   1 
ATOM 2428 C CA  . VAL A 1 340 ? 95.737  78.107  84.086  1.00 43.79  ? 340 VAL A CA  1 
ATOM 2429 C C   . VAL A 1 340 ? 94.345  77.682  84.538  1.00 43.79  ? 340 VAL A C   1 
ATOM 2430 O O   . VAL A 1 340 ? 93.686  78.399  85.294  1.00 43.79  ? 340 VAL A O   1 
ATOM 2431 C CB  . VAL A 1 340 ? 95.718  78.734  82.678  1.00 43.79  ? 340 VAL A CB  1 
ATOM 2432 C CG1 . VAL A 1 340 ? 94.608  79.764  82.551  1.00 43.79  ? 340 VAL A CG1 1 
ATOM 2433 C CG2 . VAL A 1 340 ? 97.061  79.367  82.364  1.00 43.79  ? 340 VAL A CG2 1 
ATOM 2434 N N   . SER A 1 341 ? 93.884  76.504  84.102  1.00 44.55  ? 341 SER A N   1 
ATOM 2435 C CA  . SER A 1 341 ? 92.554  76.033  84.486  1.00 44.55  ? 341 SER A CA  1 
ATOM 2436 C C   . SER A 1 341 ? 92.450  75.806  85.989  1.00 44.55  ? 341 SER A C   1 
ATOM 2437 O O   . SER A 1 341 ? 91.471  76.226  86.620  1.00 44.55  ? 341 SER A O   1 
ATOM 2438 C CB  . SER A 1 341 ? 92.215  74.746  83.740  1.00 44.55  ? 341 SER A CB  1 
ATOM 2439 O OG  . SER A 1 341 ? 92.502  74.862  82.361  1.00 44.55  ? 341 SER A OG  1 
ATOM 2440 N N   . ALA A 1 342 ? 93.449  75.145  86.582  1.00 44.61  ? 342 ALA A N   1 
ATOM 2441 C CA  . ALA A 1 342 ? 93.437  74.916  88.022  1.00 44.61  ? 342 ALA A CA  1 
ATOM 2442 C C   . ALA A 1 342 ? 93.533  76.224  88.795  1.00 44.61  ? 342 ALA A C   1 
ATOM 2443 O O   . ALA A 1 342 ? 92.831  76.407  89.796  1.00 44.61  ? 342 ALA A O   1 
ATOM 2444 C CB  . ALA A 1 342 ? 94.573  73.977  88.415  1.00 44.61  ? 342 ALA A CB  1 
ATOM 2445 N N   . ALA A 1 343 ? 94.382  77.152  88.340  1.00 45.66  ? 343 ALA A N   1 
ATOM 2446 C CA  . ALA A 1 343 ? 94.502  78.439  89.019  1.00 45.66  ? 343 ALA A CA  1 
ATOM 2447 C C   . ALA A 1 343 ? 93.206  79.238  88.936  1.00 45.66  ? 343 ALA A C   1 
ATOM 2448 O O   . ALA A 1 343 ? 92.797  79.872  89.916  1.00 45.66  ? 343 ALA A O   1 
ATOM 2449 C CB  . ALA A 1 343 ? 95.664  79.234  88.430  1.00 45.66  ? 343 ALA A CB  1 
ATOM 2450 N N   . VAL A 1 344 ? 92.538  79.206  87.782  1.00 43.52  ? 344 VAL A N   1 
ATOM 2451 C CA  . VAL A 1 344 ? 91.297  79.954  87.615  1.00 43.52  ? 344 VAL A CA  1 
ATOM 2452 C C   . VAL A 1 344 ? 90.180  79.336  88.448  1.00 43.52  ? 344 VAL A C   1 
ATOM 2453 O O   . VAL A 1 344 ? 89.389  80.054  89.069  1.00 43.52  ? 344 VAL A O   1 
ATOM 2454 C CB  . VAL A 1 344 ? 90.930  80.041  86.122  1.00 43.52  ? 344 VAL A CB  1 
ATOM 2455 C CG1 . VAL A 1 344 ? 89.503  80.526  85.934  1.00 43.52  ? 344 VAL A CG1 1 
ATOM 2456 C CG2 . VAL A 1 344 ? 91.885  80.976  85.411  1.00 43.52  ? 344 VAL A CG2 1 
ATOM 2457 N N   . MET A 1 345 ? 90.107  78.002  88.501  1.00 49.19  ? 345 MET A N   1 
ATOM 2458 C CA  . MET A 1 345 ? 89.091  77.368  89.336  1.00 49.19  ? 345 MET A CA  1 
ATOM 2459 C C   . MET A 1 345 ? 89.359  77.618  90.815  1.00 49.19  ? 345 MET A C   1 
ATOM 2460 O O   . MET A 1 345 ? 88.420  77.748  91.609  1.00 49.19  ? 345 MET A O   1 
ATOM 2461 C CB  . MET A 1 345 ? 89.018  75.869  89.050  1.00 49.19  ? 345 MET A CB  1 
ATOM 2462 C CG  . MET A 1 345 ? 87.801  75.200  89.680  1.00 49.19  ? 345 MET A CG  1 
ATOM 2463 S SD  . MET A 1 345 ? 87.440  73.555  89.043  1.00 49.19  ? 345 MET A SD  1 
ATOM 2464 C CE  . MET A 1 345 ? 89.080  73.003  88.602  1.00 49.19  ? 345 MET A CE  1 
ATOM 2465 N N   . SER A 1 346 ? 90.634  77.690  91.204  1.00 51.42  ? 346 SER A N   1 
ATOM 2466 C CA  . SER A 1 346 ? 90.968  78.017  92.586  1.00 51.42  ? 346 SER A CA  1 
ATOM 2467 C C   . SER A 1 346 ? 90.607  79.460  92.918  1.00 51.42  ? 346 SER A C   1 
ATOM 2468 O O   . SER A 1 346 ? 90.174  79.757  94.037  1.00 51.42  ? 346 SER A O   1 
ATOM 2469 C CB  . SER A 1 346 ? 92.452  77.760  92.835  1.00 51.42  ? 346 SER A CB  1 
ATOM 2470 O OG  . SER A 1 346 ? 92.764  76.388  92.689  1.00 51.42  ? 346 SER A OG  1 
ATOM 2471 N N   . SER A 1 347 ? 90.796  80.377  91.966  1.00 54.53  ? 347 SER A N   1 
ATOM 2472 C CA  . SER A 1 347 ? 90.470  81.778  92.221  1.00 54.53  ? 347 SER A CA  1 
ATOM 2473 C C   . SER A 1 347 ? 88.975  82.049  92.106  1.00 54.53  ? 347 SER A C   1 
ATOM 2474 O O   . SER A 1 347 ? 88.499  83.086  92.581  1.00 54.53  ? 347 SER A O   1 
ATOM 2475 C CB  . SER A 1 347 ? 91.239  82.681  91.258  1.00 54.53  ? 347 SER A CB  1 
ATOM 2476 O OG  . SER A 1 347 ? 90.804  82.492  89.923  1.00 54.53  ? 347 SER A OG  1 
ATOM 2477 N N   . ALA A 1 348 ? 88.229  81.147  91.462  1.00 57.31  ? 348 ALA A N   1 
ATOM 2478 C CA  . ALA A 1 348 ? 86.802  81.369  91.240  1.00 57.31  ? 348 ALA A CA  1 
ATOM 2479 C C   . ALA A 1 348 ? 86.024  81.394  92.550  1.00 57.31  ? 348 ALA A C   1 
ATOM 2480 O O   . ALA A 1 348 ? 85.124  82.220  92.734  1.00 57.31  ? 348 ALA A O   1 
ATOM 2481 C CB  . ALA A 1 348 ? 86.250  80.294  90.305  1.00 57.31  ? 348 ALA A CB  1 
ATOM 2482 N N   . ASP A 1 349 ? 86.356  80.490  93.474  1.00 65.86  ? 349 ASP A N   1 
ATOM 2483 C CA  . ASP A 1 349 ? 85.618  80.412  94.732  1.00 65.86  ? 349 ASP A CA  1 
ATOM 2484 C C   . ASP A 1 349 ? 85.928  81.589  95.651  1.00 65.86  ? 349 ASP A C   1 
ATOM 2485 O O   . ASP A 1 349 ? 85.163  81.865  96.584  1.00 65.86  ? 349 ASP A O   1 
ATOM 2486 C CB  . ASP A 1 349 ? 85.912  79.077  95.421  1.00 65.86  ? 349 ASP A CB  1 
ATOM 2487 C CG  . ASP A 1 349 ? 87.402  78.802  95.573  1.00 65.86  ? 349 ASP A CG  1 
ATOM 2488 O OD1 . ASP A 1 349 ? 88.148  79.684  96.049  1.00 65.86  ? 349 ASP A OD1 1 
ATOM 2489 O OD2 . ASP A 1 349 ? 87.833  77.693  95.195  1.00 65.86  ? 349 ASP A OD2 1 
ATOM 2490 N N   . SER A 1 350 ? 87.043  82.284  95.410  1.00 67.92  ? 350 SER A N   1 
ATOM 2491 C CA  . SER A 1 350 ? 87.403  83.431  96.237  1.00 67.92  ? 350 SER A CA  1 
ATOM 2492 C C   . SER A 1 350 ? 86.402  84.570  96.082  1.00 67.92  ? 350 SER A C   1 
ATOM 2493 O O   . SER A 1 350 ? 86.066  85.243  97.062  1.00 67.92  ? 350 SER A O   1 
ATOM 2494 C CB  . SER A 1 350 ? 88.814  83.903  95.890  1.00 67.92  ? 350 SER A CB  1 
ATOM 2495 O OG  . SER A 1 350 ? 89.760  82.868  96.092  1.00 67.92  ? 350 SER A OG  1 
ATOM 2496 N N   . SER A 1 351 ? 85.927  84.810  94.857  1.00 68.42  ? 351 SER A N   1 
ATOM 2497 C CA  . SER A 1 351 ? 84.912  85.839  94.650  1.00 68.42  ? 351 SER A CA  1 
ATOM 2498 C C   . SER A 1 351 ? 83.588  85.445  95.292  1.00 68.42  ? 351 SER A C   1 
ATOM 2499 O O   . SER A 1 351 ? 82.887  86.296  95.856  1.00 68.42  ? 351 SER A O   1 
ATOM 2500 C CB  . SER A 1 351 ? 84.727  86.105  93.156  1.00 68.42  ? 351 SER A CB  1 
ATOM 2501 O OG  . SER A 1 351 ? 83.866  87.211  92.942  1.00 68.42  ? 351 SER A OG  1 
ATOM 2502 N N   . ILE A 1 352 ? 83.230  84.159  95.210  1.00 67.71  ? 352 ILE A N   1 
ATOM 2503 C CA  . ILE A 1 352 ? 81.996  83.676  95.825  1.00 67.71  ? 352 ILE A CA  1 
ATOM 2504 C C   . ILE A 1 352 ? 82.047  83.868  97.334  1.00 67.71  ? 352 ILE A C   1 
ATOM 2505 O O   . ILE A 1 352 ? 81.081  84.330  97.950  1.00 67.71  ? 352 ILE A O   1 
ATOM 2506 C CB  . ILE A 1 352 ? 81.754  82.200  95.467  1.00 67.71  ? 352 ILE A CB  1 
ATOM 2507 C CG1 . ILE A 1 352 ? 81.987  81.953  93.981  1.00 67.71  ? 352 ILE A CG1 1 
ATOM 2508 C CG2 . ILE A 1 352 ? 80.344  81.785  95.854  1.00 67.71  ? 352 ILE A CG2 1 
ATOM 2509 C CD1 . ILE A 1 352 ? 81.996  80.490  93.633  1.00 67.71  ? 352 ILE A CD1 1 
ATOM 2510 N N   . LEU A 1 353 ? 83.180  83.510  97.948  1.00 73.93  ? 353 LEU A N   1 
ATOM 2511 C CA  . LEU A 1 353 ? 83.339  83.679  99.389  1.00 73.93  ? 353 LEU A CA  1 
ATOM 2512 C C   . LEU A 1 353 ? 83.235  85.142  99.794  1.00 73.93  ? 353 LEU A C   1 
ATOM 2513 O O   . LEU A 1 353 ? 82.550  85.476  100.769 1.00 73.93  ? 353 LEU A O   1 
ATOM 2514 C CB  . LEU A 1 353 ? 84.679  83.099  99.840  1.00 73.93  ? 353 LEU A CB  1 
ATOM 2515 C CG  . LEU A 1 353 ? 84.783  81.585  100.013 1.00 73.93  ? 353 LEU A CG  1 
ATOM 2516 C CD1 . LEU A 1 353 ? 86.236  81.165  100.131 1.00 73.93  ? 353 LEU A CD1 1 
ATOM 2517 C CD2 . LEU A 1 353 ? 84.016  81.159  101.249 1.00 73.93  ? 353 LEU A CD2 1 
ATOM 2518 N N   . SER A 1 354 ? 83.895  86.031  99.046  1.00 75.66  ? 354 SER A N   1 
ATOM 2519 C CA  . SER A 1 354 ? 83.874  87.450  99.381  1.00 75.66  ? 354 SER A CA  1 
ATOM 2520 C C   . SER A 1 354 ? 82.468  88.022  99.265  1.00 75.66  ? 354 SER A C   1 
ATOM 2521 O O   . SER A 1 354 ? 81.987  88.700  100.180 1.00 75.66  ? 354 SER A O   1 
ATOM 2522 C CB  . SER A 1 354 ? 84.844  88.216  98.481  1.00 75.66  ? 354 SER A CB  1 
ATOM 2523 O OG  . SER A 1 354 ? 84.552  87.995  97.113  1.00 75.66  ? 354 SER A OG  1 
ATOM 2524 N N   . ALA A 1 355 ? 81.781  87.734  98.156  1.00 76.45  ? 355 ALA A N   1 
ATOM 2525 C CA  . ALA A 1 355 ? 80.433  88.259  97.955  1.00 76.45  ? 355 ALA A CA  1 
ATOM 2526 C C   . ALA A 1 355 ? 79.455  87.686  98.975  1.00 76.45  ? 355 ALA A C   1 
ATOM 2527 O O   . ALA A 1 355 ? 78.582  88.399  99.481  1.00 76.45  ? 355 ALA A O   1 
ATOM 2528 C CB  . ALA A 1 355 ? 79.963  87.965  96.533  1.00 76.45  ? 355 ALA A CB  1 
ATOM 2529 N N   . SER A 1 356 ? 79.589  86.396  99.295  1.00 79.05  ? 356 SER A N   1 
ATOM 2530 C CA  . SER A 1 356 ? 78.675  85.760  100.235 1.00 79.05  ? 356 SER A CA  1 
ATOM 2531 C C   . SER A 1 356 ? 78.869  86.285  101.651 1.00 79.05  ? 356 SER A C   1 
ATOM 2532 O O   . SER A 1 356 ? 77.895  86.555  102.361 1.00 79.05  ? 356 SER A O   1 
ATOM 2533 C CB  . SER A 1 356 ? 78.865  84.247  100.190 1.00 79.05  ? 356 SER A CB  1 
ATOM 2534 O OG  . SER A 1 356 ? 78.516  83.734  98.917  1.00 79.05  ? 356 SER A OG  1 
ATOM 2535 N N   . SER A 1 357 ? 80.125  86.426  102.087 1.00 82.67  ? 357 SER A N   1 
ATOM 2536 C CA  . SER A 1 357 ? 80.386  87.008  103.400 1.00 82.67  ? 357 SER A CA  1 
ATOM 2537 C C   . SER A 1 357 ? 79.942  88.463  103.449 1.00 82.67  ? 357 SER A C   1 
ATOM 2538 O O   . SER A 1 357 ? 79.436  88.934  104.475 1.00 82.67  ? 357 SER A O   1 
ATOM 2539 C CB  . SER A 1 357 ? 81.870  86.886  103.743 1.00 82.67  ? 357 SER A CB  1 
ATOM 2540 O OG  . SER A 1 357 ? 82.153  87.489  104.993 1.00 82.67  ? 357 SER A OG  1 
ATOM 2541 N N   . MET A 1 358 ? 80.122  89.185  102.343 1.00 82.89  ? 358 MET A N   1 
ATOM 2542 C CA  . MET A 1 358 ? 79.684  90.571  102.243 1.00 82.89  ? 358 MET A CA  1 
ATOM 2543 C C   . MET A 1 358 ? 78.167  90.682  102.390 1.00 82.89  ? 358 MET A C   1 
ATOM 2544 O O   . MET A 1 358 ? 77.664  91.545  103.122 1.00 82.89  ? 358 MET A O   1 
ATOM 2545 C CB  . MET A 1 358 ? 80.211  91.126  100.912 1.00 82.89  ? 358 MET A CB  1 
ATOM 2546 C CG  . MET A 1 358 ? 80.008  92.590  100.593 1.00 82.89  ? 358 MET A CG  1 
ATOM 2547 S SD  . MET A 1 358 ? 80.410  92.903  98.853  1.00 82.89  ? 358 MET A SD  1 
ATOM 2548 C CE  . MET A 1 358 ? 78.826  92.812  98.028  1.00 82.89  ? 358 MET A CE  1 
ATOM 2549 N N   . PHE A 1 359 ? 77.425  89.778  101.741 1.00 81.93  ? 359 PHE A N   1 
ATOM 2550 C CA  . PHE A 1 359 ? 75.972  89.736  101.909 1.00 81.93  ? 359 PHE A CA  1 
ATOM 2551 C C   . PHE A 1 359 ? 75.590  89.362  103.335 1.00 81.93  ? 359 PHE A C   1 
ATOM 2552 O O   . PHE A 1 359 ? 74.682  89.967  103.919 1.00 81.93  ? 359 PHE A O   1 
ATOM 2553 C CB  . PHE A 1 359 ? 75.364  88.759  100.892 1.00 81.93  ? 359 PHE A CB  1 
ATOM 2554 C CG  . PHE A 1 359 ? 73.845  88.673  100.915 1.00 81.93  ? 359 PHE A CG  1 
ATOM 2555 C CD1 . PHE A 1 359 ? 73.163  87.968  101.903 1.00 81.93  ? 359 PHE A CD1 1 
ATOM 2556 C CD2 . PHE A 1 359 ? 73.103  89.299  99.932  1.00 81.93  ? 359 PHE A CD2 1 
ATOM 2557 C CE1 . PHE A 1 359 ? 71.783  87.900  101.906 1.00 81.93  ? 359 PHE A CE1 1 
ATOM 2558 C CE2 . PHE A 1 359 ? 71.721  89.233  99.930  1.00 81.93  ? 359 PHE A CE2 1 
ATOM 2559 C CZ  . PHE A 1 359 ? 71.062  88.533  100.919 1.00 81.93  ? 359 PHE A CZ  1 
ATOM 2560 N N   . ALA A 1 360 ? 76.259  88.359  103.905 1.00 88.19  ? 360 ALA A N   1 
ATOM 2561 C CA  . ALA A 1 360 ? 75.881  87.857  105.222 1.00 88.19  ? 360 ALA A CA  1 
ATOM 2562 C C   . ALA A 1 360 ? 76.124  88.901  106.303 1.00 88.19  ? 360 ALA A C   1 
ATOM 2563 O O   . ALA A 1 360 ? 75.361  89.000  107.270 1.00 88.19  ? 360 ALA A O   1 
ATOM 2564 C CB  . ALA A 1 360 ? 76.646  86.571  105.531 1.00 88.19  ? 360 ALA A CB  1 
ATOM 2565 N N   . ARG A 1 361 ? 77.188  89.688  106.160 1.00 92.60  ? 361 ARG A N   1 
ATOM 2566 C CA  . ARG A 1 361 ? 77.524  90.668  107.182 1.00 92.60  ? 361 ARG A CA  1 
ATOM 2567 C C   . ARG A 1 361 ? 76.784  91.989  106.987 1.00 92.60  ? 361 ARG A C   1 
ATOM 2568 O O   . ARG A 1 361 ? 76.232  92.535  107.947 1.00 92.60  ? 361 ARG A O   1 
ATOM 2569 C CB  . ARG A 1 361 ? 79.038  90.898  107.209 1.00 92.60  ? 361 ARG A CB  1 
ATOM 2570 C CG  . ARG A 1 361 ? 79.472  92.097  108.035 1.00 92.60  ? 361 ARG A CG  1 
ATOM 2571 C CD  . ARG A 1 361 ? 80.971  92.323  107.940 1.00 92.60  ? 361 ARG A CD  1 
ATOM 2572 N NE  . ARG A 1 361 ? 81.330  93.711  108.206 1.00 92.60  ? 361 ARG A NE  1 
ATOM 2573 C CZ  . ARG A 1 361 ? 81.875  94.138  109.336 1.00 92.60  ? 361 ARG A CZ  1 
ATOM 2574 N NH1 . ARG A 1 361 ? 82.130  93.311  110.337 1.00 92.60  ? 361 ARG A NH1 1 
ATOM 2575 N NH2 . ARG A 1 361 ? 82.168  95.429  109.468 1.00 92.60  ? 361 ARG A NH2 1 
ATOM 2576 N N   . ASN A 1 362 ? 76.755  92.516  105.758 1.00 91.10  ? 362 ASN A N   1 
ATOM 2577 C CA  . ASN A 1 362 ? 76.231  93.866  105.558 1.00 91.10  ? 362 ASN A CA  1 
ATOM 2578 C C   . ASN A 1 362 ? 74.711  93.917  105.690 1.00 91.10  ? 362 ASN A C   1 
ATOM 2579 O O   . ASN A 1 362 ? 74.169  94.843  106.305 1.00 91.10  ? 362 ASN A O   1 
ATOM 2580 C CB  . ASN A 1 362 ? 76.681  94.411  104.203 1.00 91.10  ? 362 ASN A CB  1 
ATOM 2581 C CG  . ASN A 1 362 ? 78.189  94.503  104.087 1.00 91.10  ? 362 ASN A CG  1 
ATOM 2582 O OD1 . ASN A 1 362 ? 78.765  94.165  103.058 1.00 91.10  ? 362 ASN A OD1 1 
ATOM 2583 N ND2 . ASN A 1 362 ? 78.838  94.961  105.151 1.00 91.10  ? 362 ASN A ND2 1 
ATOM 2584 N N   . ILE A 1 363 ? 74.001  92.942  105.123 1.00 96.02  ? 363 ILE A N   1 
ATOM 2585 C CA  . ILE A 1 363 ? 72.542  92.990  105.161 1.00 96.02  ? 363 ILE A CA  1 
ATOM 2586 C C   . ILE A 1 363 ? 71.989  92.212  106.349 1.00 96.02  ? 363 ILE A C   1 
ATOM 2587 O O   . ILE A 1 363 ? 71.311  92.782  107.210 1.00 96.02  ? 363 ILE A O   1 
ATOM 2588 C CB  . ILE A 1 363 ? 71.913  92.472  103.853 1.00 96.02  ? 363 ILE A CB  1 
ATOM 2589 C CG1 . ILE A 1 363 ? 72.168  93.442  102.702 1.00 96.02  ? 363 ILE A CG1 1 
ATOM 2590 C CG2 . ILE A 1 363 ? 70.413  92.268  104.023 1.00 96.02  ? 363 ILE A CG2 1 
ATOM 2591 C CD1 . ILE A 1 363 ? 71.555  92.980  101.400 1.00 96.02  ? 363 ILE A CD1 1 
ATOM 2592 N N   . TYR A 1 364 ? 72.260  90.907  106.403 1.00 104.20 ? 364 TYR A N   1 
ATOM 2593 C CA  . TYR A 1 364 ? 71.513  90.049  107.316 1.00 104.20 ? 364 TYR A CA  1 
ATOM 2594 C C   . TYR A 1 364 ? 71.946  90.257  108.763 1.00 104.20 ? 364 TYR A C   1 
ATOM 2595 O O   . TYR A 1 364 ? 71.114  90.249  109.677 1.00 104.20 ? 364 TYR A O   1 
ATOM 2596 C CB  . TYR A 1 364 ? 71.668  88.583  106.916 1.00 104.20 ? 364 TYR A CB  1 
ATOM 2597 C CG  . TYR A 1 364 ? 70.926  87.641  107.835 1.00 104.20 ? 364 TYR A CG  1 
ATOM 2598 C CD1 . TYR A 1 364 ? 69.539  87.565  107.803 1.00 104.20 ? 364 TYR A CD1 1 
ATOM 2599 C CD2 . TYR A 1 364 ? 71.605  86.845  108.747 1.00 104.20 ? 364 TYR A CD2 1 
ATOM 2600 C CE1 . TYR A 1 364 ? 68.850  86.713  108.642 1.00 104.20 ? 364 TYR A CE1 1 
ATOM 2601 C CE2 . TYR A 1 364 ? 70.925  85.991  109.594 1.00 104.20 ? 364 TYR A CE2 1 
ATOM 2602 C CZ  . TYR A 1 364 ? 69.547  85.929  109.537 1.00 104.20 ? 364 TYR A CZ  1 
ATOM 2603 O OH  . TYR A 1 364 ? 68.864  85.078  110.375 1.00 104.20 ? 364 TYR A OH  1 
ATOM 2604 N N   . GLN A 1 365 ? 73.247  90.429  108.996 1.00 101.55 ? 365 GLN A N   1 
ATOM 2605 C CA  . GLN A 1 365 ? 73.737  90.515  110.368 1.00 101.55 ? 365 GLN A CA  1 
ATOM 2606 C C   . GLN A 1 365 ? 73.520  91.907  110.952 1.00 101.55 ? 365 GLN A C   1 
ATOM 2607 O O   . GLN A 1 365 ? 72.913  92.058  112.019 1.00 101.55 ? 365 GLN A O   1 
ATOM 2608 C CB  . GLN A 1 365 ? 75.216  90.130  110.421 1.00 101.55 ? 365 GLN A CB  1 
ATOM 2609 C CG  . GLN A 1 365 ? 75.833  90.270  111.800 1.00 101.55 ? 365 GLN A CG  1 
ATOM 2610 C CD  . GLN A 1 365 ? 77.249  89.736  111.863 1.00 101.55 ? 365 GLN A CD  1 
ATOM 2611 O OE1 . GLN A 1 365 ? 77.566  88.710  111.260 1.00 101.55 ? 365 GLN A OE1 1 
ATOM 2612 N NE2 . GLN A 1 365 ? 78.111  90.431  112.596 1.00 101.55 ? 365 GLN A NE2 1 
ATOM 2613 N N   . LEU A 1 366 ? 74.019  92.940  110.269 1.00 100.39 ? 366 LEU A N   1 
ATOM 2614 C CA  . LEU A 1 366 ? 74.011  94.282  110.846 1.00 100.39 ? 366 LEU A CA  1 
ATOM 2615 C C   . LEU A 1 366 ? 72.612  94.890  110.853 1.00 100.39 ? 366 LEU A C   1 
ATOM 2616 O O   . LEU A 1 366 ? 72.175  95.449  111.866 1.00 100.39 ? 366 LEU A O   1 
ATOM 2617 C CB  . LEU A 1 366 ? 74.987  95.182  110.087 1.00 100.39 ? 366 LEU A CB  1 
ATOM 2618 C CG  . LEU A 1 366 ? 76.471  94.899  110.332 1.00 100.39 ? 366 LEU A CG  1 
ATOM 2619 C CD1 . LEU A 1 366 ? 77.343  95.809  109.483 1.00 100.39 ? 366 LEU A CD1 1 
ATOM 2620 C CD2 . LEU A 1 366 ? 76.808  95.048  111.807 1.00 100.39 ? 366 LEU A CD2 1 
ATOM 2621 N N   . SER A 1 367 ? 71.894  94.798  109.731 1.00 103.45 ? 367 SER A N   1 
ATOM 2622 C CA  . SER A 1 367 ? 70.603  95.474  109.633 1.00 103.45 ? 367 SER A CA  1 
ATOM 2623 C C   . SER A 1 367 ? 69.524  94.747  110.428 1.00 103.45 ? 367 SER A C   1 
ATOM 2624 O O   . SER A 1 367 ? 68.707  95.385  111.102 1.00 103.45 ? 367 SER A O   1 
ATOM 2625 C CB  . SER A 1 367 ? 70.189  95.616  108.169 1.00 103.45 ? 367 SER A CB  1 
ATOM 2626 O OG  . SER A 1 367 ? 68.917  96.229  108.055 1.00 103.45 ? 367 SER A OG  1 
ATOM 2627 N N   . PHE A 1 368 ? 69.501  93.419  110.365 1.00 108.22 ? 368 PHE A N   1 
ATOM 2628 C CA  . PHE A 1 368 ? 68.482  92.647  111.071 1.00 108.22 ? 368 PHE A CA  1 
ATOM 2629 C C   . PHE A 1 368 ? 68.933  92.319  112.491 1.00 108.22 ? 368 PHE A C   1 
ATOM 2630 O O   . PHE A 1 368 ? 68.295  91.530  113.188 1.00 108.22 ? 368 PHE A O   1 
ATOM 2631 C CB  . PHE A 1 368 ? 68.154  91.355  110.315 1.00 108.22 ? 368 PHE A CB  1 
ATOM 2632 C CG  . PHE A 1 368 ? 67.441  91.573  109.007 1.00 108.22 ? 368 PHE A CG  1 
ATOM 2633 C CD1 . PHE A 1 368 ? 66.827  92.783  108.723 1.00 108.22 ? 368 PHE A CD1 1 
ATOM 2634 C CD2 . PHE A 1 368 ? 67.385  90.562  108.062 1.00 108.22 ? 368 PHE A CD2 1 
ATOM 2635 C CE1 . PHE A 1 368 ? 66.173  92.979  107.519 1.00 108.22 ? 368 PHE A CE1 1 
ATOM 2636 C CE2 . PHE A 1 368 ? 66.732  90.751  106.857 1.00 108.22 ? 368 PHE A CE2 1 
ATOM 2637 C CZ  . PHE A 1 368 ? 66.126  91.962  106.586 1.00 108.22 ? 368 PHE A CZ  1 
ATOM 2638 N N   . GLU A 1 376 ? 73.639  80.469  113.580 1.00 116.59 ? 376 GLU A N   1 
ATOM 2639 C CA  . GLU A 1 376 ? 72.481  81.063  112.923 1.00 116.59 ? 376 GLU A CA  1 
ATOM 2640 C C   . GLU A 1 376 ? 72.886  81.742  111.619 1.00 116.59 ? 376 GLU A C   1 
ATOM 2641 O O   . GLU A 1 376 ? 72.132  81.743  110.647 1.00 116.59 ? 376 GLU A O   1 
ATOM 2642 C CB  . GLU A 1 376 ? 71.795  82.068  113.852 1.00 116.59 ? 376 GLU A CB  1 
ATOM 2643 C CG  . GLU A 1 376 ? 70.358  82.386  113.473 1.00 116.59 ? 376 GLU A CG  1 
ATOM 2644 C CD  . GLU A 1 376 ? 69.556  82.930  114.640 1.00 116.59 ? 376 GLU A CD  1 
ATOM 2645 O OE1 . GLU A 1 376 ? 70.034  82.835  115.790 1.00 116.59 ? 376 GLU A OE1 1 
ATOM 2646 O OE2 . GLU A 1 376 ? 68.446  83.453  114.407 1.00 116.59 ? 376 GLU A OE2 1 
ATOM 2647 N N   . ILE A 1 377 ? 74.089  82.320  111.611 1.00 112.10 ? 377 ILE A N   1 
ATOM 2648 C CA  . ILE A 1 377 ? 74.582  83.003  110.418 1.00 112.10 ? 377 ILE A CA  1 
ATOM 2649 C C   . ILE A 1 377 ? 74.960  81.991  109.341 1.00 112.10 ? 377 ILE A C   1 
ATOM 2650 O O   . ILE A 1 377 ? 74.956  82.305  108.143 1.00 112.10 ? 377 ILE A O   1 
ATOM 2651 C CB  . ILE A 1 377 ? 75.761  83.928  110.787 1.00 112.10 ? 377 ILE A CB  1 
ATOM 2652 C CG1 . ILE A 1 377 ? 76.109  84.871  109.631 1.00 112.10 ? 377 ILE A CG1 1 
ATOM 2653 C CG2 . ILE A 1 377 ? 76.982  83.123  111.220 1.00 112.10 ? 377 ILE A CG2 1 
ATOM 2654 C CD1 . ILE A 1 377 ? 75.035  85.887  109.330 1.00 112.10 ? 377 ILE A CD1 1 
ATOM 2655 N N   . VAL A 1 378 ? 75.266  80.754  109.746 1.00 108.08 ? 378 VAL A N   1 
ATOM 2656 C CA  . VAL A 1 378 ? 75.788  79.759  108.811 1.00 108.08 ? 378 VAL A CA  1 
ATOM 2657 C C   . VAL A 1 378 ? 74.727  79.342  107.798 1.00 108.08 ? 378 VAL A C   1 
ATOM 2658 O O   . VAL A 1 378 ? 75.027  79.138  106.617 1.00 108.08 ? 378 VAL A O   1 
ATOM 2659 C CB  . VAL A 1 378 ? 76.361  78.550  109.578 1.00 108.08 ? 378 VAL A CB  1 
ATOM 2660 C CG1 . VAL A 1 378 ? 77.634  78.948  110.305 1.00 108.08 ? 378 VAL A CG1 1 
ATOM 2661 C CG2 . VAL A 1 378 ? 75.347  78.004  110.574 1.00 108.08 ? 378 VAL A CG2 1 
ATOM 2662 N N   . TRP A 1 379 ? 73.469  79.235  108.232 1.00 105.46 ? 379 TRP A N   1 
ATOM 2663 C CA  . TRP A 1 379 ? 72.405  78.793  107.334 1.00 105.46 ? 379 TRP A CA  1 
ATOM 2664 C C   . TRP A 1 379 ? 72.114  79.842  106.265 1.00 105.46 ? 379 TRP A C   1 
ATOM 2665 O O   . TRP A 1 379 ? 71.999  79.526  105.071 1.00 105.46 ? 379 TRP A O   1 
ATOM 2666 C CB  . TRP A 1 379 ? 71.149  78.479  108.147 1.00 105.46 ? 379 TRP A CB  1 
ATOM 2667 C CG  . TRP A 1 379 ? 70.018  77.924  107.345 1.00 105.46 ? 379 TRP A CG  1 
ATOM 2668 C CD1 . TRP A 1 379 ? 68.836  78.543  107.056 1.00 105.46 ? 379 TRP A CD1 1 
ATOM 2669 C CD2 . TRP A 1 379 ? 69.952  76.629  106.739 1.00 105.46 ? 379 TRP A CD2 1 
ATOM 2670 N NE1 . TRP A 1 379 ? 68.041  77.715  106.302 1.00 105.46 ? 379 TRP A NE1 1 
ATOM 2671 C CE2 . TRP A 1 379 ? 68.704  76.534  106.092 1.00 105.46 ? 379 TRP A CE2 1 
ATOM 2672 C CE3 . TRP A 1 379 ? 70.829  75.542  106.677 1.00 105.46 ? 379 TRP A CE3 1 
ATOM 2673 C CZ2 . TRP A 1 379 ? 68.311  75.395  105.393 1.00 105.46 ? 379 TRP A CZ2 1 
ATOM 2674 C CZ3 . TRP A 1 379 ? 70.436  74.412  105.981 1.00 105.46 ? 379 TRP A CZ3 1 
ATOM 2675 C CH2 . TRP A 1 379 ? 69.189  74.348  105.349 1.00 105.46 ? 379 TRP A CH2 1 
ATOM 2676 N N   . VAL A 1 380 ? 72.001  81.105  106.681 1.00 98.00  ? 380 VAL A N   1 
ATOM 2677 C CA  . VAL A 1 380 ? 71.745  82.185  105.735 1.00 98.00  ? 380 VAL A CA  1 
ATOM 2678 C C   . VAL A 1 380 ? 72.944  82.386  104.816 1.00 98.00  ? 380 VAL A C   1 
ATOM 2679 O O   . VAL A 1 380 ? 72.784  82.678  103.627 1.00 98.00  ? 380 VAL A O   1 
ATOM 2680 C CB  . VAL A 1 380 ? 71.375  83.474  106.492 1.00 98.00  ? 380 VAL A CB  1 
ATOM 2681 C CG1 . VAL A 1 380 ? 71.012  84.587  105.518 1.00 98.00  ? 380 VAL A CG1 1 
ATOM 2682 C CG2 . VAL A 1 380 ? 70.223  83.200  107.443 1.00 98.00  ? 380 VAL A CG2 1 
ATOM 2683 N N   . MET A 1 381 ? 74.162  82.213  105.340 1.00 95.79  ? 381 MET A N   1 
ATOM 2684 C CA  . MET A 1 381 ? 75.344  82.282  104.486 1.00 95.79  ? 381 MET A CA  1 
ATOM 2685 C C   . MET A 1 381 ? 75.371  81.148  103.467 1.00 95.79  ? 381 MET A C   1 
ATOM 2686 O O   . MET A 1 381 ? 75.775  81.362  102.320 1.00 95.79  ? 381 MET A O   1 
ATOM 2687 C CB  . MET A 1 381 ? 76.615  82.265  105.336 1.00 95.79  ? 381 MET A CB  1 
ATOM 2688 C CG  . MET A 1 381 ? 77.895  82.456  104.536 1.00 95.79  ? 381 MET A CG  1 
ATOM 2689 S SD  . MET A 1 381 ? 79.382  82.445  105.554 1.00 95.79  ? 381 MET A SD  1 
ATOM 2690 C CE  . MET A 1 381 ? 79.237  84.021  106.391 1.00 95.79  ? 381 MET A CE  1 
ATOM 2691 N N   . ARG A 1 382 ? 74.946  79.945  103.863 1.00 89.85  ? 382 ARG A N   1 
ATOM 2692 C CA  . ARG A 1 382 ? 74.857  78.823  102.932 1.00 89.85  ? 382 ARG A CA  1 
ATOM 2693 C C   . ARG A 1 382 ? 73.868  79.120  101.809 1.00 89.85  ? 382 ARG A C   1 
ATOM 2694 O O   . ARG A 1 382 ? 74.159  78.894  100.624 1.00 89.85  ? 382 ARG A O   1 
ATOM 2695 C CB  . ARG A 1 382 ? 74.434  77.565  103.692 1.00 89.85  ? 382 ARG A CB  1 
ATOM 2696 C CG  . ARG A 1 382 ? 75.563  76.814  104.378 1.00 89.85  ? 382 ARG A CG  1 
ATOM 2697 C CD  . ARG A 1 382 ? 75.116  75.416  104.779 1.00 89.85  ? 382 ARG A CD  1 
ATOM 2698 N NE  . ARG A 1 382 ? 75.829  74.926  105.952 1.00 89.85  ? 382 ARG A NE  1 
ATOM 2699 C CZ  . ARG A 1 382 ? 75.285  74.170  106.896 1.00 89.85  ? 382 ARG A CZ  1 
ATOM 2700 N NH1 . ARG A 1 382 ? 74.017  73.798  106.840 1.00 89.85  ? 382 ARG A NH1 1 
ATOM 2701 N NH2 . ARG A 1 382 ? 76.033  73.779  107.925 1.00 89.85  ? 382 ARG A NH2 1 
ATOM 2702 N N   . ILE A 1 383 ? 72.690  79.635  102.170 1.00 81.01  ? 383 ILE A N   1 
ATOM 2703 C CA  . ILE A 1 383 ? 71.687  79.974  101.164 1.00 81.01  ? 383 ILE A CA  1 
ATOM 2704 C C   . ILE A 1 383 ? 72.190  81.101  100.267 1.00 81.01  ? 383 ILE A C   1 
ATOM 2705 O O   . ILE A 1 383 ? 71.927  81.116  99.058  1.00 81.01  ? 383 ILE A O   1 
ATOM 2706 C CB  . ILE A 1 383 ? 70.351  80.331  101.844 1.00 81.01  ? 383 ILE A CB  1 
ATOM 2707 C CG1 . ILE A 1 383 ? 69.815  79.130  102.623 1.00 81.01  ? 383 ILE A CG1 1 
ATOM 2708 C CG2 . ILE A 1 383 ? 69.313  80.781  100.826 1.00 81.01  ? 383 ILE A CG2 1 
ATOM 2709 C CD1 . ILE A 1 383 ? 68.618  79.454  103.482 1.00 81.01  ? 383 ILE A CD1 1 
ATOM 2710 N N   . THR A 1 384 ? 72.935  82.050  100.840 1.00 75.91  ? 384 THR A N   1 
ATOM 2711 C CA  . THR A 1 384 ? 73.508  83.140  100.057 1.00 75.91  ? 384 THR A CA  1 
ATOM 2712 C C   . THR A 1 384 ? 74.520  82.615  99.047  1.00 75.91  ? 384 THR A C   1 
ATOM 2713 O O   . THR A 1 384 ? 74.529  83.040  97.886  1.00 75.91  ? 384 THR A O   1 
ATOM 2714 C CB  . THR A 1 384 ? 74.153  84.160  100.994 1.00 75.91  ? 384 THR A CB  1 
ATOM 2715 O OG1 . THR A 1 384 ? 73.131  84.835  101.736 1.00 75.91  ? 384 THR A OG1 1 
ATOM 2716 C CG2 . THR A 1 384 ? 74.956  85.184  100.212 1.00 75.91  ? 384 THR A CG2 1 
ATOM 2717 N N   . VAL A 1 385 ? 75.372  81.676  99.472  1.00 71.30  ? 385 VAL A N   1 
ATOM 2718 C CA  . VAL A 1 385 ? 76.314  81.034  98.557  1.00 71.30  ? 385 VAL A CA  1 
ATOM 2719 C C   . VAL A 1 385 ? 75.571  80.358  97.417  1.00 71.30  ? 385 VAL A C   1 
ATOM 2720 O O   . VAL A 1 385 ? 75.919  80.529  96.241  1.00 71.30  ? 385 VAL A O   1 
ATOM 2721 C CB  . VAL A 1 385 ? 77.201  80.024  99.312  1.00 71.30  ? 385 VAL A CB  1 
ATOM 2722 C CG1 . VAL A 1 385 ? 77.986  79.174  98.328  1.00 71.30  ? 385 VAL A CG1 1 
ATOM 2723 C CG2 . VAL A 1 385 ? 78.151  80.733  100.249 1.00 71.30  ? 385 VAL A CG2 1 
ATOM 2724 N N   . PHE A 1 386 ? 74.521  79.600  97.745  1.00 66.47  ? 386 PHE A N   1 
ATOM 2725 C CA  . PHE A 1 386 ? 73.780  78.864  96.724  1.00 66.47  ? 386 PHE A CA  1 
ATOM 2726 C C   . PHE A 1 386 ? 73.129  79.808  95.715  1.00 66.47  ? 386 PHE A C   1 
ATOM 2727 O O   . PHE A 1 386 ? 73.256  79.625  94.497  1.00 66.47  ? 386 PHE A O   1 
ATOM 2728 C CB  . PHE A 1 386 ? 72.731  77.970  97.387  1.00 66.47  ? 386 PHE A CB  1 
ATOM 2729 C CG  . PHE A 1 386 ? 71.943  77.139  96.417  1.00 66.47  ? 386 PHE A CG  1 
ATOM 2730 C CD1 . PHE A 1 386 ? 72.505  76.018  95.831  1.00 66.47  ? 386 PHE A CD1 1 
ATOM 2731 C CD2 . PHE A 1 386 ? 70.641  77.479  96.092  1.00 66.47  ? 386 PHE A CD2 1 
ATOM 2732 C CE1 . PHE A 1 386 ? 71.783  75.251  94.937  1.00 66.47  ? 386 PHE A CE1 1 
ATOM 2733 C CE2 . PHE A 1 386 ? 69.913  76.716  95.198  1.00 66.47  ? 386 PHE A CE2 1 
ATOM 2734 C CZ  . PHE A 1 386 ? 70.485  75.600  94.620  1.00 66.47  ? 386 PHE A CZ  1 
ATOM 2735 N N   . VAL A 1 387 ? 72.444  80.843  96.210  1.00 58.57  ? 387 VAL A N   1 
ATOM 2736 C CA  . VAL A 1 387 ? 71.727  81.758  95.326  1.00 58.57  ? 387 VAL A CA  1 
ATOM 2737 C C   . VAL A 1 387 ? 72.698  82.585  94.490  1.00 58.57  ? 387 VAL A C   1 
ATOM 2738 O O   . VAL A 1 387 ? 72.468  82.807  93.295  1.00 58.57  ? 387 VAL A O   1 
ATOM 2739 C CB  . VAL A 1 387 ? 70.768  82.647  96.141  1.00 58.57  ? 387 VAL A CB  1 
ATOM 2740 C CG1 . VAL A 1 387 ? 70.096  83.677  95.249  1.00 58.57  ? 387 VAL A CG1 1 
ATOM 2741 C CG2 . VAL A 1 387 ? 69.710  81.792  96.813  1.00 58.57  ? 387 VAL A CG2 1 
ATOM 2742 N N   . PHE A 1 388 ? 73.796  83.054  95.094  1.00 52.59  ? 388 PHE A N   1 
ATOM 2743 C CA  . PHE A 1 388 ? 74.776  83.836  94.347  1.00 52.59  ? 388 PHE A CA  1 
ATOM 2744 C C   . PHE A 1 388 ? 75.438  82.994  93.265  1.00 52.59  ? 388 PHE A C   1 
ATOM 2745 O O   . PHE A 1 388 ? 75.632  83.461  92.136  1.00 52.59  ? 388 PHE A O   1 
ATOM 2746 C CB  . PHE A 1 388 ? 75.821  84.419  95.302  1.00 52.59  ? 388 PHE A CB  1 
ATOM 2747 C CG  . PHE A 1 388 ? 76.844  85.292  94.628  1.00 52.59  ? 388 PHE A CG  1 
ATOM 2748 C CD1 . PHE A 1 388 ? 78.039  84.763  94.164  1.00 52.59  ? 388 PHE A CD1 1 
ATOM 2749 C CD2 . PHE A 1 388 ? 76.605  86.644  94.452  1.00 52.59  ? 388 PHE A CD2 1 
ATOM 2750 C CE1 . PHE A 1 388 ? 78.974  85.566  93.541  1.00 52.59  ? 388 PHE A CE1 1 
ATOM 2751 C CE2 . PHE A 1 388 ? 77.538  87.452  93.831  1.00 52.59  ? 388 PHE A CE2 1 
ATOM 2752 C CZ  . PHE A 1 388 ? 78.723  86.912  93.374  1.00 52.59  ? 388 PHE A CZ  1 
ATOM 2753 N N   . GLY A 1 389 ? 75.785  81.745  93.588  1.00 47.95  ? 389 GLY A N   1 
ATOM 2754 C CA  . GLY A 1 389 ? 76.351  80.865  92.581  1.00 47.95  ? 389 GLY A CA  1 
ATOM 2755 C C   . GLY A 1 389 ? 75.387  80.584  91.446  1.00 47.95  ? 389 GLY A C   1 
ATOM 2756 O O   . GLY A 1 389 ? 75.773  80.607  90.275  1.00 47.95  ? 389 GLY A O   1 
ATOM 2757 N N   . ALA A 1 390 ? 74.113  80.340  91.777  1.00 46.99  ? 390 ALA A N   1 
ATOM 2758 C CA  . ALA A 1 390 ? 73.114  80.084  90.743  1.00 46.99  ? 390 ALA A CA  1 
ATOM 2759 C C   . ALA A 1 390 ? 72.884  81.301  89.854  1.00 46.99  ? 390 ALA A C   1 
ATOM 2760 O O   . ALA A 1 390 ? 72.794  81.158  88.630  1.00 46.99  ? 390 ALA A O   1 
ATOM 2761 C CB  . ALA A 1 390 ? 71.800  79.637  91.382  1.00 46.99  ? 390 ALA A CB  1 
ATOM 2762 N N   . SER A 1 391 ? 72.800  82.499  90.436  1.00 43.70  ? 391 SER A N   1 
ATOM 2763 C CA  . SER A 1 391 ? 72.610  83.706  89.636  1.00 43.70  ? 391 SER A CA  1 
ATOM 2764 C C   . SER A 1 391 ? 73.819  83.995  88.754  1.00 43.70  ? 391 SER A C   1 
ATOM 2765 O O   . SER A 1 391 ? 73.664  84.338  87.571  1.00 43.70  ? 391 SER A O   1 
ATOM 2766 C CB  . SER A 1 391 ? 72.320  84.897  90.546  1.00 43.70  ? 391 SER A CB  1 
ATOM 2767 O OG  . SER A 1 391 ? 71.089  84.727  91.224  1.00 43.70  ? 391 SER A OG  1 
ATOM 2768 N N   . ALA A 1 392 ? 75.028  83.845  89.307  1.00 40.81  ? 392 ALA A N   1 
ATOM 2769 C CA  . ALA A 1 392 ? 76.236  84.079  88.528  1.00 40.81  ? 392 ALA A CA  1 
ATOM 2770 C C   . ALA A 1 392 ? 76.356  83.085  87.381  1.00 40.81  ? 392 ALA A C   1 
ATOM 2771 O O   . ALA A 1 392 ? 76.698  83.473  86.259  1.00 40.81  ? 392 ALA A O   1 
ATOM 2772 C CB  . ALA A 1 392 ? 77.466  84.015  89.430  1.00 40.81  ? 392 ALA A CB  1 
ATOM 2773 N N   . THR A 1 393 ? 76.047  81.804  87.622  1.00 42.86  ? 393 THR A N   1 
ATOM 2774 C CA  . THR A 1 393 ? 76.162  80.839  86.532  1.00 42.86  ? 393 THR A CA  1 
ATOM 2775 C C   . THR A 1 393 ? 75.044  81.018  85.510  1.00 42.86  ? 393 THR A C   1 
ATOM 2776 O O   . THR A 1 393 ? 75.261  80.799  84.314  1.00 42.86  ? 393 THR A O   1 
ATOM 2777 C CB  . THR A 1 393 ? 76.207  79.398  87.060  1.00 42.86  ? 393 THR A CB  1 
ATOM 2778 O OG1 . THR A 1 393 ? 76.517  78.510  85.978  1.00 42.86  ? 393 THR A OG1 1 
ATOM 2779 C CG2 . THR A 1 393 ? 74.893  78.962  87.666  1.00 42.86  ? 393 THR A CG2 1 
ATOM 2780 N N   . ALA A 1 394 ? 73.856  81.455  85.943  1.00 44.23  ? 394 ALA A N   1 
ATOM 2781 C CA  . ALA A 1 394 ? 72.774  81.700  84.994  1.00 44.23  ? 394 ALA A CA  1 
ATOM 2782 C C   . ALA A 1 394 ? 73.117  82.849  84.058  1.00 44.23  ? 394 ALA A C   1 
ATOM 2783 O O   . ALA A 1 394 ? 72.924  82.755  82.840  1.00 44.23  ? 394 ALA A O   1 
ATOM 2784 C CB  . ALA A 1 394 ? 71.472  81.983  85.740  1.00 44.23  ? 394 ALA A CB  1 
ATOM 2785 N N   . MET A 1 395 ? 73.648  83.942  84.607  1.00 46.68  ? 395 MET A N   1 
ATOM 2786 C CA  . MET A 1 395 ? 74.015  85.063  83.748  1.00 46.68  ? 395 MET A CA  1 
ATOM 2787 C C   . MET A 1 395 ? 75.282  84.770  82.946  1.00 46.68  ? 395 MET A C   1 
ATOM 2788 O O   . MET A 1 395 ? 75.467  85.311  81.849  1.00 46.68  ? 395 MET A O   1 
ATOM 2789 C CB  . MET A 1 395 ? 74.142  86.339  84.575  1.00 46.68  ? 395 MET A CB  1 
ATOM 2790 C CG  . MET A 1 395 ? 74.405  87.568  83.739  1.00 46.68  ? 395 MET A CG  1 
ATOM 2791 S SD  . MET A 1 395 ? 74.516  89.042  84.733  1.00 46.68  ? 395 MET A SD  1 
ATOM 2792 C CE  . MET A 1 395 ? 72.789  89.229  85.165  1.00 46.68  ? 395 MET A CE  1 
ATOM 2793 N N   . ALA A 1 396 ? 76.157  83.902  83.460  1.00 42.69  ? 396 ALA A N   1 
ATOM 2794 C CA  . ALA A 1 396 ? 77.278  83.432  82.655  1.00 42.69  ? 396 ALA A CA  1 
ATOM 2795 C C   . ALA A 1 396 ? 76.791  82.632  81.455  1.00 42.69  ? 396 ALA A C   1 
ATOM 2796 O O   . ALA A 1 396 ? 77.356  82.734  80.359  1.00 42.69  ? 396 ALA A O   1 
ATOM 2797 C CB  . ALA A 1 396 ? 78.225  82.596  83.515  1.00 42.69  ? 396 ALA A CB  1 
ATOM 2798 N N   . LEU A 1 397 ? 75.747  81.820  81.648  1.00 44.90  ? 397 LEU A N   1 
ATOM 2799 C CA  . LEU A 1 397 ? 75.143  81.098  80.533  1.00 44.90  ? 397 LEU A CA  1 
ATOM 2800 C C   . LEU A 1 397 ? 74.480  82.051  79.547  1.00 44.90  ? 397 LEU A C   1 
ATOM 2801 O O   . LEU A 1 397 ? 74.593  81.870  78.329  1.00 44.90  ? 397 LEU A O   1 
ATOM 2802 C CB  . LEU A 1 397 ? 74.118  80.090  81.055  1.00 44.90  ? 397 LEU A CB  1 
ATOM 2803 C CG  . LEU A 1 397 ? 74.623  78.871  81.824  1.00 44.90  ? 397 LEU A CG  1 
ATOM 2804 C CD1 . LEU A 1 397 ? 73.459  78.115  82.444  1.00 44.90  ? 397 LEU A CD1 1 
ATOM 2805 C CD2 . LEU A 1 397 ? 75.443  77.969  80.935  1.00 44.90  ? 397 LEU A CD2 1 
ATOM 2806 N N   . LEU A 1 398 ? 73.778  83.068  80.053  1.00 44.78  ? 398 LEU A N   1 
ATOM 2807 C CA  . LEU A 1 398 ? 73.019  83.954  79.174  1.00 44.78  ? 398 LEU A CA  1 
ATOM 2808 C C   . LEU A 1 398 ? 73.931  84.884  78.380  1.00 44.78  ? 398 LEU A C   1 
ATOM 2809 O O   . LEU A 1 398 ? 73.728  85.077  77.176  1.00 44.78  ? 398 LEU A O   1 
ATOM 2810 C CB  . LEU A 1 398 ? 72.010  84.759  79.991  1.00 44.78  ? 398 LEU A CB  1 
ATOM 2811 C CG  . LEU A 1 398 ? 70.833  83.963  80.561  1.00 44.78  ? 398 LEU A CG  1 
ATOM 2812 C CD1 . LEU A 1 398 ? 70.107  84.769  81.622  1.00 44.78  ? 398 LEU A CD1 1 
ATOM 2813 C CD2 . LEU A 1 398 ? 69.879  83.543  79.457  1.00 44.78  ? 398 LEU A CD2 1 
ATOM 2814 N N   . THR A 1 399 ? 74.932  85.470  79.030  1.00 45.62  ? 399 THR A N   1 
ATOM 2815 C CA  . THR A 1 399 ? 75.813  86.414  78.358  1.00 45.62  ? 399 THR A CA  1 
ATOM 2816 C C   . THR A 1 399 ? 76.783  85.692  77.427  1.00 45.62  ? 399 THR A C   1 
ATOM 2817 O O   . THR A 1 399 ? 77.076  84.503  77.583  1.00 45.62  ? 399 THR A O   1 
ATOM 2818 C CB  . THR A 1 399 ? 76.595  87.244  79.375  1.00 45.62  ? 399 THR A CB  1 
ATOM 2819 O OG1 . THR A 1 399 ? 77.125  86.381  80.388  1.00 45.62  ? 399 THR A OG1 1 
ATOM 2820 C CG2 . THR A 1 399 ? 75.692  88.283  80.018  1.00 45.62  ? 399 THR A CG2 1 
ATOM 2821 N N   . LYS A 1 400 ? 77.284  86.436  76.439  1.00 46.30  ? 400 LYS A N   1 
ATOM 2822 C CA  . LYS A 1 400 ? 78.193  85.898  75.434  1.00 46.30  ? 400 LYS A CA  1 
ATOM 2823 C C   . LYS A 1 400 ? 79.518  86.653  75.388  1.00 46.30  ? 400 LYS A C   1 
ATOM 2824 O O   . LYS A 1 400 ? 80.218  86.605  74.372  1.00 46.30  ? 400 LYS A O   1 
ATOM 2825 C CB  . LYS A 1 400 ? 77.531  85.913  74.055  1.00 46.30  ? 400 LYS A CB  1 
ATOM 2826 C CG  . LYS A 1 400 ? 76.271  85.066  73.958  1.00 46.30  ? 400 LYS A CG  1 
ATOM 2827 C CD  . LYS A 1 400 ? 76.559  83.597  74.223  1.00 46.30  ? 400 LYS A CD  1 
ATOM 2828 C CE  . LYS A 1 400 ? 77.422  82.994  73.127  1.00 46.30  ? 400 LYS A CE  1 
ATOM 2829 N NZ  . LYS A 1 400 ? 76.718  82.979  71.817  1.00 46.30  ? 400 LYS A NZ  1 
ATOM 2830 N N   . THR A 1 401 ? 79.878  87.356  76.460  1.00 38.72  ? 401 THR A N   1 
ATOM 2831 C CA  . THR A 1 401 ? 81.121  88.115  76.496  1.00 38.72  ? 401 THR A CA  1 
ATOM 2832 C C   . THR A 1 401 ? 81.667  88.159  77.915  1.00 38.72  ? 401 THR A C   1 
ATOM 2833 O O   . THR A 1 401 ? 80.900  88.180  78.881  1.00 38.72  ? 401 THR A O   1 
ATOM 2834 C CB  . THR A 1 401 ? 80.916  89.537  75.950  1.00 38.72  ? 401 THR A CB  1 
ATOM 2835 O OG1 . THR A 1 401 ? 82.147  90.267  76.022  1.00 38.72  ? 401 THR A OG1 1 
ATOM 2836 C CG2 . THR A 1 401 ? 79.831  90.275  76.722  1.00 38.72  ? 401 THR A CG2 1 
ATOM 2837 N N   . VAL A 1 402 ? 82.996  88.143  78.034  1.00 34.35  ? 402 VAL A N   1 
ATOM 2838 C CA  . VAL A 1 402 ? 83.640  88.272  79.337  1.00 34.35  ? 402 VAL A CA  1 
ATOM 2839 C C   . VAL A 1 402 ? 84.075  89.713  79.577  1.00 34.35  ? 402 VAL A C   1 
ATOM 2840 O O   . VAL A 1 402 ? 83.909  90.251  80.680  1.00 34.35  ? 402 VAL A O   1 
ATOM 2841 C CB  . VAL A 1 402 ? 84.825  87.292  79.438  1.00 34.35  ? 402 VAL A CB  1 
ATOM 2842 C CG1 . VAL A 1 402 ? 85.527  87.427  80.779  1.00 34.35  ? 402 VAL A CG1 1 
ATOM 2843 C CG2 . VAL A 1 402 ? 84.353  85.866  79.223  1.00 34.35  ? 402 VAL A CG2 1 
ATOM 2844 N N   . TYR A 1 403 ? 84.636  90.356  78.549  1.00 34.99  ? 403 TYR A N   1 
ATOM 2845 C CA  . TYR A 1 403 ? 85.021  91.760  78.660  1.00 34.99  ? 403 TYR A CA  1 
ATOM 2846 C C   . TYR A 1 403 ? 83.804  92.646  78.884  1.00 34.99  ? 403 TYR A C   1 
ATOM 2847 O O   . TYR A 1 403 ? 83.872  93.640  79.615  1.00 34.99  ? 403 TYR A O   1 
ATOM 2848 C CB  . TYR A 1 403 ? 85.779  92.200  77.408  1.00 34.99  ? 403 TYR A CB  1 
ATOM 2849 C CG  . TYR A 1 403 ? 86.220  93.643  77.453  1.00 34.99  ? 403 TYR A CG  1 
ATOM 2850 C CD1 . TYR A 1 403 ? 87.307  94.031  78.221  1.00 34.99  ? 403 TYR A CD1 1 
ATOM 2851 C CD2 . TYR A 1 403 ? 85.539  94.620  76.741  1.00 34.99  ? 403 TYR A CD2 1 
ATOM 2852 C CE1 . TYR A 1 403 ? 87.711  95.350  78.271  1.00 34.99  ? 403 TYR A CE1 1 
ATOM 2853 C CE2 . TYR A 1 403 ? 85.933  95.941  76.788  1.00 34.99  ? 403 TYR A CE2 1 
ATOM 2854 C CZ  . TYR A 1 403 ? 87.020  96.300  77.553  1.00 34.99  ? 403 TYR A CZ  1 
ATOM 2855 O OH  . TYR A 1 403 ? 87.418  97.615  77.602  1.00 34.99  ? 403 TYR A OH  1 
ATOM 2856 N N   . GLY A 1 404 ? 82.683  92.310  78.244  1.00 37.11  ? 404 GLY A N   1 
ATOM 2857 C CA  . GLY A 1 404 ? 81.458  93.053  78.480  1.00 37.11  ? 404 GLY A CA  1 
ATOM 2858 C C   . GLY A 1 404 ? 80.972  92.935  79.910  1.00 37.11  ? 404 GLY A C   1 
ATOM 2859 O O   . GLY A 1 404 ? 80.519  93.915  80.502  1.00 37.11  ? 404 GLY A O   1 
ATOM 2860 N N   . LEU A 1 405 ? 81.068  91.736  80.488  1.00 35.38  ? 405 LEU A N   1 
ATOM 2861 C CA  . LEU A 1 405 ? 80.699  91.552  81.889  1.00 35.38  ? 405 LEU A CA  1 
ATOM 2862 C C   . LEU A 1 405 ? 81.635  92.322  82.812  1.00 35.38  ? 405 LEU A C   1 
ATOM 2863 O O   . LEU A 1 405 ? 81.198  92.884  83.821  1.00 35.38  ? 405 LEU A O   1 
ATOM 2864 C CB  . LEU A 1 405 ? 80.699  90.065  82.240  1.00 35.38  ? 405 LEU A CB  1 
ATOM 2865 C CG  . LEU A 1 405 ? 79.482  89.256  81.789  1.00 35.38  ? 405 LEU A CG  1 
ATOM 2866 C CD1 . LEU A 1 405 ? 79.731  87.770  81.967  1.00 35.38  ? 405 LEU A CD1 1 
ATOM 2867 C CD2 . LEU A 1 405 ? 78.239  89.686  82.546  1.00 35.38  ? 405 LEU A CD2 1 
ATOM 2868 N N   . TRP A 1 406 ? 82.926  92.360  82.478  1.00 37.67  ? 406 TRP A N   1 
ATOM 2869 C CA  . TRP A 1 406 ? 83.896  93.133  83.253  1.00 37.67  ? 406 TRP A CA  1 
ATOM 2870 C C   . TRP A 1 406 ? 83.572  94.627  83.213  1.00 37.67  ? 406 TRP A C   1 
ATOM 2871 O O   . TRP A 1 406 ? 83.535  95.305  84.253  1.00 37.67  ? 406 TRP A O   1 
ATOM 2872 C CB  . TRP A 1 406 ? 85.292  92.853  82.693  1.00 37.67  ? 406 TRP A CB  1 
ATOM 2873 C CG  . TRP A 1 406 ? 86.452  93.362  83.482  1.00 37.67  ? 406 TRP A CG  1 
ATOM 2874 C CD1 . TRP A 1 406 ? 86.422  94.008  84.682  1.00 37.67  ? 406 TRP A CD1 1 
ATOM 2875 C CD2 . TRP A 1 406 ? 87.832  93.244  83.124  1.00 37.67  ? 406 TRP A CD2 1 
ATOM 2876 N NE1 . TRP A 1 406 ? 87.699  94.307  85.089  1.00 37.67  ? 406 TRP A NE1 1 
ATOM 2877 C CE2 . TRP A 1 406 ? 88.583  93.847  84.149  1.00 37.67  ? 406 TRP A CE2 1 
ATOM 2878 C CE3 . TRP A 1 406 ? 88.505  92.690  82.031  1.00 37.67  ? 406 TRP A CE3 1 
ATOM 2879 C CZ2 . TRP A 1 406 ? 89.972  93.911  84.114  1.00 37.67  ? 406 TRP A CZ2 1 
ATOM 2880 C CZ3 . TRP A 1 406 ? 89.881  92.755  81.999  1.00 37.67  ? 406 TRP A CZ3 1 
ATOM 2881 C CH2 . TRP A 1 406 ? 90.600  93.360  83.032  1.00 37.67  ? 406 TRP A CH2 1 
ATOM 2882 N N   . TYR A 1 407 ? 83.312  95.148  82.012  1.00 38.95  ? 407 TYR A N   1 
ATOM 2883 C CA  . TYR A 1 407 ? 82.961  96.555  81.854  1.00 38.95  ? 407 TYR A CA  1 
ATOM 2884 C C   . TYR A 1 407 ? 81.650  96.875  82.557  1.00 38.95  ? 407 TYR A C   1 
ATOM 2885 O O   . TYR A 1 407 ? 81.499  97.950  83.142  1.00 38.95  ? 407 TYR A O   1 
ATOM 2886 C CB  . TYR A 1 407 ? 82.884  96.898  80.364  1.00 38.95  ? 407 TYR A CB  1 
ATOM 2887 C CG  . TYR A 1 407 ? 82.624  98.355  80.045  1.00 38.95  ? 407 TYR A CG  1 
ATOM 2888 C CD1 . TYR A 1 407 ? 81.329  98.854  79.964  1.00 38.95  ? 407 TYR A CD1 1 
ATOM 2889 C CD2 . TYR A 1 407 ? 83.676  99.229  79.808  1.00 38.95  ? 407 TYR A CD2 1 
ATOM 2890 C CE1 . TYR A 1 407 ? 81.091  100.181 79.669  1.00 38.95  ? 407 TYR A CE1 1 
ATOM 2891 C CE2 . TYR A 1 407 ? 83.447  100.557 79.512  1.00 38.95  ? 407 TYR A CE2 1 
ATOM 2892 C CZ  . TYR A 1 407 ? 82.152  101.027 79.443  1.00 38.95  ? 407 TYR A CZ  1 
ATOM 2893 O OH  . TYR A 1 407 ? 81.918  102.349 79.148  1.00 38.95  ? 407 TYR A OH  1 
ATOM 2894 N N   . LEU A 1 408 ? 80.692  95.948  82.519  1.00 39.48  ? 408 LEU A N   1 
ATOM 2895 C CA  . LEU A 1 408 ? 79.400  96.184  83.152  1.00 39.48  ? 408 LEU A CA  1 
ATOM 2896 C C   . LEU A 1 408 ? 79.507  96.118  84.671  1.00 39.48  ? 408 LEU A C   1 
ATOM 2897 O O   . LEU A 1 408 ? 78.759  96.800  85.380  1.00 39.48  ? 408 LEU A O   1 
ATOM 2898 C CB  . LEU A 1 408 ? 78.386  95.173  82.625  1.00 39.48  ? 408 LEU A CB  1 
ATOM 2899 C CG  . LEU A 1 408 ? 76.924  95.326  83.022  1.00 39.48  ? 408 LEU A CG  1 
ATOM 2900 C CD1 . LEU A 1 408 ? 76.406  96.689  82.614  1.00 39.48  ? 408 LEU A CD1 1 
ATOM 2901 C CD2 . LEU A 1 408 ? 76.125  94.236  82.350  1.00 39.48  ? 408 LEU A CD2 1 
ATOM 2902 N N   . SER A 1 409 ? 80.419  95.292  85.190  1.00 37.32  ? 409 SER A N   1 
ATOM 2903 C CA  . SER A 1 409 ? 80.705  95.309  86.619  1.00 37.32  ? 409 SER A CA  1 
ATOM 2904 C C   . SER A 1 409 ? 81.315  96.638  87.036  1.00 37.32  ? 409 SER A C   1 
ATOM 2905 O O   . SER A 1 409 ? 80.985  97.173  88.100  1.00 37.32  ? 409 SER A O   1 
ATOM 2906 C CB  . SER A 1 409 ? 81.642  94.161  86.990  1.00 37.32  ? 409 SER A CB  1 
ATOM 2907 O OG  . SER A 1 409 ? 82.868  94.253  86.290  1.00 37.32  ? 409 SER A OG  1 
ATOM 2908 N N   . SER A 1 410 ? 82.219  97.178  86.216  1.00 38.64  ? 410 SER A N   1 
ATOM 2909 C CA  . SER A 1 410 ? 82.802  98.481  86.531  1.00 38.64  ? 410 SER A CA  1 
ATOM 2910 C C   . SER A 1 410 ? 81.773  99.601  86.403  1.00 38.64  ? 410 SER A C   1 
ATOM 2911 O O   . SER A 1 410 ? 81.836  100.595 87.136  1.00 38.64  ? 410 SER A O   1 
ATOM 2912 C CB  . SER A 1 410 ? 84.001  98.754  85.626  1.00 38.64  ? 410 SER A CB  1 
ATOM 2913 O OG  . SER A 1 410 ? 85.034  97.814  85.851  1.00 38.64  ? 410 SER A OG  1 
ATOM 2914 N N   . ASP A 1 411 ? 80.823  99.452  85.474  1.00 42.34  ? 411 ASP A N   1 
ATOM 2915 C CA  . ASP A 1 411 ? 79.933  100.547 85.091  1.00 42.34  ? 411 ASP A CA  1 
ATOM 2916 C C   . ASP A 1 411 ? 79.033  100.967 86.246  1.00 42.34  ? 411 ASP A C   1 
ATOM 2917 O O   . ASP A 1 411 ? 78.952  102.153 86.584  1.00 42.34  ? 411 ASP A O   1 
ATOM 2918 C CB  . ASP A 1 411 ? 79.106  100.108 83.874  1.00 42.34  ? 411 ASP A CB  1 
ATOM 2919 C CG  . ASP A 1 411 ? 78.186  101.201 83.323  1.00 42.34  ? 411 ASP A CG  1 
ATOM 2920 O OD1 . ASP A 1 411 ? 77.376  101.802 84.060  1.00 42.34  ? 411 ASP A OD1 1 
ATOM 2921 O OD2 . ASP A 1 411 ? 78.272  101.450 82.105  1.00 42.34  ? 411 ASP A OD2 1 
ATOM 2922 N N   . LEU A 1 412 ? 78.333  100.009 86.848  1.00 43.46  ? 412 LEU A N   1 
ATOM 2923 C CA  . LEU A 1 412 ? 77.381  100.340 87.899  1.00 43.46  ? 412 LEU A CA  1 
ATOM 2924 C C   . LEU A 1 412 ? 78.077  100.848 89.152  1.00 43.46  ? 412 LEU A C   1 
ATOM 2925 O O   . LEU A 1 412 ? 77.572  101.766 89.810  1.00 43.46  ? 412 LEU A O   1 
ATOM 2926 C CB  . LEU A 1 412 ? 76.523  99.120  88.219  1.00 43.46  ? 412 LEU A CB  1 
ATOM 2927 C CG  . LEU A 1 412 ? 75.424  99.310  89.255  1.00 43.46  ? 412 LEU A CG  1 
ATOM 2928 C CD1 . LEU A 1 412 ? 74.409  100.331 88.771  1.00 43.46  ? 412 LEU A CD1 1 
ATOM 2929 C CD2 . LEU A 1 412 ? 74.767  97.981  89.509  1.00 43.46  ? 412 LEU A CD2 1 
ATOM 2930 N N   . VAL A 1 413 ? 79.237  100.276 89.478  1.00 41.19  ? 413 VAL A N   1 
ATOM 2931 C CA  . VAL A 1 413 ? 80.024  100.761 90.605  1.00 41.19  ? 413 VAL A CA  1 
ATOM 2932 C C   . VAL A 1 413 ? 80.474  102.197 90.364  1.00 41.19  ? 413 VAL A C   1 
ATOM 2933 O O   . VAL A 1 413 ? 80.342  103.050 91.246  1.00 41.19  ? 413 VAL A O   1 
ATOM 2934 C CB  . VAL A 1 413 ? 81.214  99.821  90.863  1.00 41.19  ? 413 VAL A CB  1 
ATOM 2935 C CG1 . VAL A 1 413 ? 82.032  100.311 92.034  1.00 41.19  ? 413 VAL A CG1 1 
ATOM 2936 C CG2 . VAL A 1 413 ? 80.718  98.411  91.126  1.00 41.19  ? 413 VAL A CG2 1 
ATOM 2937 N N   . TYR A 1 414 ? 80.952  102.498 89.153  1.00 38.37  ? 414 TYR A N   1 
ATOM 2938 C CA  . TYR A 1 414 ? 81.368  103.856 88.813  1.00 38.37  ? 414 TYR A CA  1 
ATOM 2939 C C   . TYR A 1 414 ? 80.204  104.835 88.891  1.00 38.37  ? 414 TYR A C   1 
ATOM 2940 O O   . TYR A 1 414 ? 80.362  105.964 89.367  1.00 38.37  ? 414 TYR A O   1 
ATOM 2941 C CB  . TYR A 1 414 ? 81.975  103.866 87.412  1.00 38.37  ? 414 TYR A CB  1 
ATOM 2942 C CG  . TYR A 1 414 ? 82.288  105.239 86.868  1.00 38.37  ? 414 TYR A CG  1 
ATOM 2943 C CD1 . TYR A 1 414 ? 83.163  106.089 87.529  1.00 38.37  ? 414 TYR A CD1 1 
ATOM 2944 C CD2 . TYR A 1 414 ? 81.710  105.684 85.687  1.00 38.37  ? 414 TYR A CD2 1 
ATOM 2945 C CE1 . TYR A 1 414 ? 83.455  107.339 87.028  1.00 38.37  ? 414 TYR A CE1 1 
ATOM 2946 C CE2 . TYR A 1 414 ? 81.994  106.932 85.180  1.00 38.37  ? 414 TYR A CE2 1 
ATOM 2947 C CZ  . TYR A 1 414 ? 82.866  107.755 85.854  1.00 38.37  ? 414 TYR A CZ  1 
ATOM 2948 O OH  . TYR A 1 414 ? 83.152  108.999 85.348  1.00 38.37  ? 414 TYR A OH  1 
ATOM 2949 N N   . ILE A 1 415 ? 79.030  104.422 88.415  1.00 41.68  ? 415 ILE A N   1 
ATOM 2950 C CA  . ILE A 1 415 ? 77.875  105.314 88.405  1.00 41.68  ? 415 ILE A CA  1 
ATOM 2951 C C   . ILE A 1 415 ? 77.397  105.595 89.826  1.00 41.68  ? 415 ILE A C   1 
ATOM 2952 O O   . ILE A 1 415 ? 77.110  106.743 90.184  1.00 41.68  ? 415 ILE A O   1 
ATOM 2953 C CB  . ILE A 1 415 ? 76.751  104.725 87.532  1.00 41.68  ? 415 ILE A CB  1 
ATOM 2954 C CG1 . ILE A 1 415 ? 77.138  104.783 86.053  1.00 41.68  ? 415 ILE A CG1 1 
ATOM 2955 C CG2 . ILE A 1 415 ? 75.440  105.461 87.758  1.00 41.68  ? 415 ILE A CG2 1 
ATOM 2956 C CD1 . ILE A 1 415 ? 77.319  106.183 85.525  1.00 41.68  ? 415 ILE A CD1 1 
ATOM 2957 N N   . VAL A 1 416 ? 77.325  104.562 90.665  1.00 42.95  ? 416 VAL A N   1 
ATOM 2958 C CA  . VAL A 1 416 ? 76.664  104.707 91.957  1.00 42.95  ? 416 VAL A CA  1 
ATOM 2959 C C   . VAL A 1 416 ? 77.659  104.940 93.089  1.00 42.95  ? 416 VAL A C   1 
ATOM 2960 O O   . VAL A 1 416 ? 77.603  105.969 93.769  1.00 42.95  ? 416 VAL A O   1 
ATOM 2961 C CB  . VAL A 1 416 ? 75.782  103.479 92.249  1.00 42.95  ? 416 VAL A CB  1 
ATOM 2962 C CG1 . VAL A 1 416 ? 75.290  103.511 93.680  1.00 42.95  ? 416 VAL A CG1 1 
ATOM 2963 C CG2 . VAL A 1 416 ? 74.611  103.429 91.285  1.00 42.95  ? 416 VAL A CG2 1 
ATOM 2964 N N   . ILE A 1 417 ? 78.573  103.991 93.303  1.00 44.14  ? 417 ILE A N   1 
ATOM 2965 C CA  . ILE A 1 417 ? 79.358  103.963 94.535  1.00 44.14  ? 417 ILE A CA  1 
ATOM 2966 C C   . ILE A 1 417 ? 80.443  105.036 94.536  1.00 44.14  ? 417 ILE A C   1 
ATOM 2967 O O   . ILE A 1 417 ? 80.688  105.677 95.564  1.00 44.14  ? 417 ILE A O   1 
ATOM 2968 C CB  . ILE A 1 417 ? 79.943  102.552 94.737  1.00 44.14  ? 417 ILE A CB  1 
ATOM 2969 C CG1 . ILE A 1 417 ? 78.817  101.529 94.882  1.00 44.14  ? 417 ILE A CG1 1 
ATOM 2970 C CG2 . ILE A 1 417 ? 80.844  102.502 95.957  1.00 44.14  ? 417 ILE A CG2 1 
ATOM 2971 C CD1 . ILE A 1 417 ? 79.275  100.100 94.741  1.00 44.14  ? 417 ILE A CD1 1 
ATOM 2972 N N   . PHE A 1 418 ? 81.109  105.244 93.397  1.00 41.39  ? 418 PHE A N   1 
ATOM 2973 C CA  . PHE A 1 418 ? 82.256  106.154 93.353  1.00 41.39  ? 418 PHE A CA  1 
ATOM 2974 C C   . PHE A 1 418 ? 81.916  107.601 93.707  1.00 41.39  ? 418 PHE A C   1 
ATOM 2975 O O   . PHE A 1 418 ? 82.691  108.216 94.462  1.00 41.39  ? 418 PHE A O   1 
ATOM 2976 C CB  . PHE A 1 418 ? 82.944  106.052 91.986  1.00 41.39  ? 418 PHE A CB  1 
ATOM 2977 C CG  . PHE A 1 418 ? 84.123  106.970 91.833  1.00 41.39  ? 418 PHE A CG  1 
ATOM 2978 C CD1 . PHE A 1 418 ? 85.316  106.700 92.481  1.00 41.39  ? 418 PHE A CD1 1 
ATOM 2979 C CD2 . PHE A 1 418 ? 84.039  108.104 91.043  1.00 41.39  ? 418 PHE A CD2 1 
ATOM 2980 C CE1 . PHE A 1 418 ? 86.401  107.543 92.344  1.00 41.39  ? 418 PHE A CE1 1 
ATOM 2981 C CE2 . PHE A 1 418 ? 85.119  108.949 90.903  1.00 41.39  ? 418 PHE A CE2 1 
ATOM 2982 C CZ  . PHE A 1 418 ? 86.301  108.669 91.554  1.00 41.39  ? 418 PHE A CZ  1 
ATOM 2983 N N   . PRO A 1 419 ? 80.829  108.218 93.203  1.00 42.82  ? 419 PRO A N   1 
ATOM 2984 C CA  . PRO A 1 419 ? 80.460  109.542 93.738  1.00 42.82  ? 419 PRO A CA  1 
ATOM 2985 C C   . PRO A 1 419 ? 80.177  109.529 95.228  1.00 42.82  ? 419 PRO A C   1 
ATOM 2986 O O   . PRO A 1 419 ? 80.547  110.472 95.938  1.00 42.82  ? 419 PRO A O   1 
ATOM 2987 C CB  . PRO A 1 419 ? 79.207  109.901 92.933  1.00 42.82  ? 419 PRO A CB  1 
ATOM 2988 C CG  . PRO A 1 419 ? 79.372  109.184 91.675  1.00 42.82  ? 419 PRO A CG  1 
ATOM 2989 C CD  . PRO A 1 419 ? 79.966  107.871 92.058  1.00 42.82  ? 419 PRO A CD  1 
ATOM 2990 N N   . GLN A 1 420 ? 79.546  108.465 95.725  1.00 50.15  ? 420 GLN A N   1 
ATOM 2991 C CA  . GLN A 1 420 ? 79.284  108.359 97.154  1.00 50.15  ? 420 GLN A CA  1 
ATOM 2992 C C   . GLN A 1 420 ? 80.572  108.186 97.947  1.00 50.15  ? 420 GLN A C   1 
ATOM 2993 O O   . GLN A 1 420 ? 80.696  108.734 99.047  1.00 50.15  ? 420 GLN A O   1 
ATOM 2994 C CB  . GLN A 1 420 ? 78.333  107.196 97.423  1.00 50.15  ? 420 GLN A CB  1 
ATOM 2995 C CG  . GLN A 1 420 ? 77.040  107.259 96.635  1.00 50.15  ? 420 GLN A CG  1 
ATOM 2996 C CD  . GLN A 1 420 ? 76.233  108.496 96.927  1.00 50.15  ? 420 GLN A CD  1 
ATOM 2997 O OE1 . GLN A 1 420 ? 76.092  109.379 96.081  1.00 50.15  ? 420 GLN A OE1 1 
ATOM 2998 N NE2 . GLN A 1 420 ? 75.697  108.572 98.134  1.00 50.15  ? 420 GLN A NE2 1 
ATOM 2999 N N   . LEU A 1 421 ? 81.533  107.430 97.410  1.00 49.96  ? 421 LEU A N   1 
ATOM 3000 C CA  . LEU A 1 421 ? 82.827  107.287 98.071  1.00 49.96  ? 421 LEU A CA  1 
ATOM 3001 C C   . LEU A 1 421 ? 83.560  108.621 98.127  1.00 49.96  ? 421 LEU A C   1 
ATOM 3002 O O   . LEU A 1 421 ? 84.137  108.984 99.159  1.00 49.96  ? 421 LEU A O   1 
ATOM 3003 C CB  . LEU A 1 421 ? 83.674  106.239 97.350  1.00 49.96  ? 421 LEU A CB  1 
ATOM 3004 C CG  . LEU A 1 421 ? 84.940  105.813 98.096  1.00 49.96  ? 421 LEU A CG  1 
ATOM 3005 C CD1 . LEU A 1 421 ? 84.584  105.097 99.389  1.00 49.96  ? 421 LEU A CD1 1 
ATOM 3006 C CD2 . LEU A 1 421 ? 85.831  104.951 97.225  1.00 49.96  ? 421 LEU A CD2 1 
ATOM 3007 N N   . LEU A 1 422 ? 83.532  109.372 97.021  1.00 47.21  ? 422 LEU A N   1 
ATOM 3008 C CA  . LEU A 1 422 ? 84.126  110.704 97.009  1.00 47.21  ? 422 LEU A CA  1 
ATOM 3009 C C   . LEU A 1 422 ? 83.455  111.609 98.031  1.00 47.21  ? 422 LEU A C   1 
ATOM 3010 O O   . LEU A 1 422 ? 84.126  112.382 98.725  1.00 47.21  ? 422 LEU A O   1 
ATOM 3011 C CB  . LEU A 1 422 ? 84.018  111.321 95.615  1.00 47.21  ? 422 LEU A CB  1 
ATOM 3012 C CG  . LEU A 1 422 ? 84.939  110.818 94.504  1.00 47.21  ? 422 LEU A CG  1 
ATOM 3013 C CD1 . LEU A 1 422 ? 84.765  111.674 93.261  1.00 47.21  ? 422 LEU A CD1 1 
ATOM 3014 C CD2 . LEU A 1 422 ? 86.386  110.807 94.952  1.00 47.21  ? 422 LEU A CD2 1 
ATOM 3015 N N   . CYS A 1 423 ? 82.129  111.516 98.146  1.00 53.03  ? 423 CYS A N   1 
ATOM 3016 C CA  . CYS A 1 423 ? 81.402  112.371 99.076  1.00 53.03  ? 423 CYS A CA  1 
ATOM 3017 C C   . CYS A 1 423 ? 81.694  112.010 100.528 1.00 53.03  ? 423 CYS A C   1 
ATOM 3018 O O   . CYS A 1 423 ? 81.792  112.899 101.380 1.00 53.03  ? 423 CYS A O   1 
ATOM 3019 C CB  . CYS A 1 423 ? 79.905  112.299 98.789  1.00 53.03  ? 423 CYS A CB  1 
ATOM 3020 S SG  . CYS A 1 423 ? 79.404  113.239 97.333  1.00 53.03  ? 423 CYS A SG  1 
ATOM 3021 N N   . VAL A 1 424 ? 81.829  110.720 100.842 1.00 55.26  ? 424 VAL A N   1 
ATOM 3022 C CA  . VAL A 1 424 ? 82.057  110.351 102.238 1.00 55.26  ? 424 VAL A CA  1 
ATOM 3023 C C   . VAL A 1 424 ? 83.515  110.573 102.625 1.00 55.26  ? 424 VAL A C   1 
ATOM 3024 O O   . VAL A 1 424 ? 83.828  110.776 103.804 1.00 55.26  ? 424 VAL A O   1 
ATOM 3025 C CB  . VAL A 1 424 ? 81.614  108.902 102.519 1.00 55.26  ? 424 VAL A CB  1 
ATOM 3026 C CG1 . VAL A 1 424 ? 80.113  108.756 102.341 1.00 55.26  ? 424 VAL A CG1 1 
ATOM 3027 C CG2 . VAL A 1 424 ? 82.380  107.906 101.671 1.00 55.26  ? 424 VAL A CG2 1 
ATOM 3028 N N   . LEU A 1 425 ? 84.432  110.539 101.654 1.00 56.59  ? 425 LEU A N   1 
ATOM 3029 C CA  . LEU A 1 425 ? 85.842  110.697 101.996 1.00 56.59  ? 425 LEU A CA  1 
ATOM 3030 C C   . LEU A 1 425 ? 86.287  112.156 101.941 1.00 56.59  ? 425 LEU A C   1 
ATOM 3031 O O   . LEU A 1 425 ? 86.765  112.706 102.938 1.00 56.59  ? 425 LEU A O   1 
ATOM 3032 C CB  . LEU A 1 425 ? 86.705  109.831 101.076 1.00 56.59  ? 425 LEU A CB  1 
ATOM 3033 C CG  . LEU A 1 425 ? 86.555  108.323 101.289 1.00 56.59  ? 425 LEU A CG  1 
ATOM 3034 C CD1 . LEU A 1 425 ? 87.462  107.550 100.353 1.00 56.59  ? 425 LEU A CD1 1 
ATOM 3035 C CD2 . LEU A 1 425 ? 86.832  107.952 102.737 1.00 56.59  ? 425 LEU A CD2 1 
ATOM 3036 N N   . PHE A 1 426 ? 86.136  112.801 100.784 1.00 55.05  ? 426 PHE A N   1 
ATOM 3037 C CA  . PHE A 1 426 ? 86.733  114.113 100.567 1.00 55.05  ? 426 PHE A CA  1 
ATOM 3038 C C   . PHE A 1 426 ? 85.779  115.278 100.788 1.00 55.05  ? 426 PHE A C   1 
ATOM 3039 O O   . PHE A 1 426 ? 86.242  116.416 100.909 1.00 55.05  ? 426 PHE A O   1 
ATOM 3040 C CB  . PHE A 1 426 ? 87.304  114.200 99.147  1.00 55.05  ? 426 PHE A CB  1 
ATOM 3041 C CG  . PHE A 1 426 ? 88.268  113.100 98.818  1.00 55.05  ? 426 PHE A CG  1 
ATOM 3042 C CD1 . PHE A 1 426 ? 89.298  112.784 99.686  1.00 55.05  ? 426 PHE A CD1 1 
ATOM 3043 C CD2 . PHE A 1 426 ? 88.144  112.380 97.644  1.00 55.05  ? 426 PHE A CD2 1 
ATOM 3044 C CE1 . PHE A 1 426 ? 90.186  111.771 99.387  1.00 55.05  ? 426 PHE A CE1 1 
ATOM 3045 C CE2 . PHE A 1 426 ? 89.030  111.367 97.341  1.00 55.05  ? 426 PHE A CE2 1 
ATOM 3046 C CZ  . PHE A 1 426 ? 90.052  111.062 98.213  1.00 55.05  ? 426 PHE A CZ  1 
ATOM 3047 N N   . VAL A 1 427 ? 84.474  115.034 100.843 1.00 59.23  ? 427 VAL A N   1 
ATOM 3048 C CA  . VAL A 1 427 ? 83.482  116.094 100.983 1.00 59.23  ? 427 VAL A CA  1 
ATOM 3049 C C   . VAL A 1 427 ? 82.963  116.100 102.413 1.00 59.23  ? 427 VAL A C   1 
ATOM 3050 O O   . VAL A 1 427 ? 82.628  115.046 102.967 1.00 59.23  ? 427 VAL A O   1 
ATOM 3051 C CB  . VAL A 1 427 ? 82.332  115.918 99.976  1.00 59.23  ? 427 VAL A CB  1 
ATOM 3052 C CG1 . VAL A 1 427 ? 81.415  117.127 100.001 1.00 59.23  ? 427 VAL A CG1 1 
ATOM 3053 C CG2 . VAL A 1 427 ? 82.887  115.704 98.578  1.00 59.23  ? 427 VAL A CG2 1 
ATOM 3054 N N   . LYS A 1 428 ? 82.910  117.282 103.015 1.00 71.59  ? 428 LYS A N   1 
ATOM 3055 C CA  . LYS A 1 428 ? 82.363  117.455 104.352 1.00 71.59  ? 428 LYS A CA  1 
ATOM 3056 C C   . LYS A 1 428 ? 80.980  118.083 104.260 1.00 71.59  ? 428 LYS A C   1 
ATOM 3057 O O   . LYS A 1 428 ? 80.759  119.013 103.479 1.00 71.59  ? 428 LYS A O   1 
ATOM 3058 C CB  . LYS A 1 428 ? 83.281  118.327 105.210 1.00 71.59  ? 428 LYS A CB  1 
ATOM 3059 C CG  . LYS A 1 428 ? 83.008  118.234 106.702 1.00 71.59  ? 428 LYS A CG  1 
ATOM 3060 C CD  . LYS A 1 428 ? 84.186  118.748 107.512 1.00 71.59  ? 428 LYS A CD  1 
ATOM 3061 C CE  . LYS A 1 428 ? 83.881  118.727 109.001 1.00 71.59  ? 428 LYS A CE  1 
ATOM 3062 N NZ  . LYS A 1 428 ? 85.122  118.739 109.823 1.00 71.59  ? 428 LYS A NZ  1 
ATOM 3063 N N   . GLY A 1 429 ? 80.051  117.571 105.062 1.00 71.54  ? 429 GLY A N   1 
ATOM 3064 C CA  . GLY A 1 429 ? 78.693  118.071 105.056 1.00 71.54  ? 429 GLY A CA  1 
ATOM 3065 C C   . GLY A 1 429 ? 77.715  117.292 104.207 1.00 71.54  ? 429 GLY A C   1 
ATOM 3066 O O   . GLY A 1 429 ? 76.558  117.710 104.089 1.00 71.54  ? 429 GLY A O   1 
ATOM 3067 N N   . THR A 1 430 ? 78.135  116.181 103.608 1.00 64.05  ? 430 THR A N   1 
ATOM 3068 C CA  . THR A 1 430 ? 77.201  115.322 102.895 1.00 64.05  ? 430 THR A CA  1 
ATOM 3069 C C   . THR A 1 430 ? 76.321  114.565 103.887 1.00 64.05  ? 430 THR A C   1 
ATOM 3070 O O   . THR A 1 430 ? 76.678  114.381 105.054 1.00 64.05  ? 430 THR A O   1 
ATOM 3071 C CB  . THR A 1 430 ? 77.950  114.344 101.987 1.00 64.05  ? 430 THR A CB  1 
ATOM 3072 O OG1 . THR A 1 430 ? 77.011  113.609 101.193 1.00 64.05  ? 430 THR A OG1 1 
ATOM 3073 C CG2 . THR A 1 430 ? 78.786  113.374 102.804 1.00 64.05  ? 430 THR A CG2 1 
ATOM 3074 N N   . ASN A 1 431 ? 75.149  114.141 103.420 1.00 65.99  ? 431 ASN A N   1 
ATOM 3075 C CA  . ASN A 1 431 ? 74.188  113.483 104.293 1.00 65.99  ? 431 ASN A CA  1 
ATOM 3076 C C   . ASN A 1 431 ? 73.356  112.500 103.478 1.00 65.99  ? 431 ASN A C   1 
ATOM 3077 O O   . ASN A 1 431 ? 73.641  112.230 102.308 1.00 65.99  ? 431 ASN A O   1 
ATOM 3078 C CB  . ASN A 1 431 ? 73.308  114.509 105.014 1.00 65.99  ? 431 ASN A CB  1 
ATOM 3079 C CG  . ASN A 1 431 ? 72.804  115.599 104.094 1.00 65.99  ? 431 ASN A CG  1 
ATOM 3080 O OD1 . ASN A 1 431 ? 72.271  115.324 103.022 1.00 65.99  ? 431 ASN A OD1 1 
ATOM 3081 N ND2 . ASN A 1 431 ? 72.971  116.848 104.511 1.00 65.99  ? 431 ASN A ND2 1 
ATOM 3082 N N   . THR A 1 432 ? 72.315  111.961 104.119 1.00 68.30  ? 432 THR A N   1 
ATOM 3083 C CA  . THR A 1 432 ? 71.535  110.887 103.510 1.00 68.30  ? 432 THR A CA  1 
ATOM 3084 C C   . THR A 1 432 ? 70.618  111.412 102.409 1.00 68.30  ? 432 THR A C   1 
ATOM 3085 O O   . THR A 1 432 ? 70.379  110.720 101.412 1.00 68.30  ? 432 THR A O   1 
ATOM 3086 C CB  . THR A 1 432 ? 70.727  110.159 104.585 1.00 68.30  ? 432 THR A CB  1 
ATOM 3087 O OG1 . THR A 1 432 ? 71.590  109.809 105.673 1.00 68.30  ? 432 THR A OG1 1 
ATOM 3088 C CG2 . THR A 1 432 ? 70.120  108.881 104.026 1.00 68.30  ? 432 THR A CG2 1 
ATOM 3089 N N   . TYR A 1 433 ? 70.084  112.627 102.577 1.00 73.93  ? 433 TYR A N   1 
ATOM 3090 C CA  . TYR A 1 433 ? 69.218  113.212 101.555 1.00 73.93  ? 433 TYR A CA  1 
ATOM 3091 C C   . TYR A 1 433 ? 69.967  113.407 100.244 1.00 73.93  ? 433 TYR A C   1 
ATOM 3092 O O   . TYR A 1 433 ? 69.475  113.035 99.171  1.00 73.93  ? 433 TYR A O   1 
ATOM 3093 C CB  . TYR A 1 433 ? 68.652  114.544 102.044 1.00 73.93  ? 433 TYR A CB  1 
ATOM 3094 C CG  . TYR A 1 433 ? 67.795  114.438 103.279 1.00 73.93  ? 433 TYR A CG  1 
ATOM 3095 C CD1 . TYR A 1 433 ? 68.155  115.082 104.454 1.00 73.93  ? 433 TYR A CD1 1 
ATOM 3096 C CD2 . TYR A 1 433 ? 66.614  113.712 103.264 1.00 73.93  ? 433 TYR A CD2 1 
ATOM 3097 C CE1 . TYR A 1 433 ? 67.370  114.990 105.585 1.00 73.93  ? 433 TYR A CE1 1 
ATOM 3098 C CE2 . TYR A 1 433 ? 65.823  113.615 104.388 1.00 73.93  ? 433 TYR A CE2 1 
ATOM 3099 C CZ  . TYR A 1 433 ? 66.205  114.257 105.545 1.00 73.93  ? 433 TYR A CZ  1 
ATOM 3100 O OH  . TYR A 1 433 ? 65.418  114.164 106.666 1.00 73.93  ? 433 TYR A OH  1 
ATOM 3101 N N   . GLY A 1 434 ? 71.167  113.984 100.316 1.00 61.17  ? 434 GLY A N   1 
ATOM 3102 C CA  . GLY A 1 434 ? 71.985  114.116 99.124  1.00 61.17  ? 434 GLY A CA  1 
ATOM 3103 C C   . GLY A 1 434 ? 72.411  112.774 98.565  1.00 61.17  ? 434 GLY A C   1 
ATOM 3104 O O   . GLY A 1 434 ? 72.522  112.607 97.350  1.00 61.17  ? 434 GLY A O   1 
ATOM 3105 N N   . ALA A 1 435 ? 72.645  111.799 99.446  1.00 58.55  ? 435 ALA A N   1 
ATOM 3106 C CA  . ALA A 1 435 ? 73.004  110.456 99.002  1.00 58.55  ? 435 ALA A CA  1 
ATOM 3107 C C   . ALA A 1 435 ? 71.894  109.840 98.161  1.00 58.55  ? 435 ALA A C   1 
ATOM 3108 O O   . ALA A 1 435 ? 72.144  109.310 97.072  1.00 58.55  ? 435 ALA A O   1 
ATOM 3109 C CB  . ALA A 1 435 ? 73.311  109.574 100.212 1.00 58.55  ? 435 ALA A CB  1 
ATOM 3110 N N   . VAL A 1 436 ? 70.653  109.929 98.640  1.00 57.89  ? 436 VAL A N   1 
ATOM 3111 C CA  . VAL A 1 436 ? 69.517  109.370 97.914  1.00 57.89  ? 436 VAL A CA  1 
ATOM 3112 C C   . VAL A 1 436 ? 69.241  110.159 96.640  1.00 57.89  ? 436 VAL A C   1 
ATOM 3113 O O   . VAL A 1 436 ? 68.906  109.578 95.602  1.00 57.89  ? 436 VAL A O   1 
ATOM 3114 C CB  . VAL A 1 436 ? 68.287  109.309 98.837  1.00 57.89  ? 436 VAL A CB  1 
ATOM 3115 C CG1 . VAL A 1 436 ? 67.050  108.872 98.073  1.00 57.89  ? 436 VAL A CG1 1 
ATOM 3116 C CG2 . VAL A 1 436 ? 68.553  108.351 99.976  1.00 57.89  ? 436 VAL A CG2 1 
ATOM 3117 N N   . ALA A 1 437 ? 69.381  111.487 96.689  1.00 56.79  ? 437 ALA A N   1 
ATOM 3118 C CA  . ALA A 1 437 ? 69.169  112.298 95.493  1.00 56.79  ? 437 ALA A CA  1 
ATOM 3119 C C   . ALA A 1 437 ? 70.188  111.966 94.410  1.00 56.79  ? 437 ALA A C   1 
ATOM 3120 O O   . ALA A 1 437 ? 69.833  111.813 93.235  1.00 56.79  ? 437 ALA A O   1 
ATOM 3121 C CB  . ALA A 1 437 ? 69.225  113.782 95.851  1.00 56.79  ? 437 ALA A CB  1 
ATOM 3122 N N   . GLY A 1 438 ? 71.462  111.837 94.789  1.00 54.39  ? 438 GLY A N   1 
ATOM 3123 C CA  . GLY A 1 438 ? 72.478  111.452 93.826  1.00 54.39  ? 438 GLY A CA  1 
ATOM 3124 C C   . GLY A 1 438 ? 72.284  110.041 93.308  1.00 54.39  ? 438 GLY A C   1 
ATOM 3125 O O   . GLY A 1 438 ? 72.487  109.777 92.123  1.00 54.39  ? 438 GLY A O   1 
ATOM 3126 N N   . TYR A 1 439 ? 71.880  109.123 94.190  1.00 56.60  ? 439 TYR A N   1 
ATOM 3127 C CA  . TYR A 1 439 ? 71.557  107.757 93.787  1.00 56.60  ? 439 TYR A CA  1 
ATOM 3128 C C   . TYR A 1 439 ? 70.465  107.741 92.722  1.00 56.60  ? 439 TYR A C   1 
ATOM 3129 O O   . TYR A 1 439 ? 70.629  107.138 91.651  1.00 56.60  ? 439 TYR A O   1 
ATOM 3130 C CB  . TYR A 1 439 ? 71.127  106.974 95.031  1.00 56.60  ? 439 TYR A CB  1 
ATOM 3131 C CG  . TYR A 1 439 ? 71.090  105.469 94.913  1.00 56.60  ? 439 TYR A CG  1 
ATOM 3132 C CD1 . TYR A 1 439 ? 69.990  104.821 94.370  1.00 56.60  ? 439 TYR A CD1 1 
ATOM 3133 C CD2 . TYR A 1 439 ? 72.142  104.693 95.377  1.00 56.60  ? 439 TYR A CD2 1 
ATOM 3134 C CE1 . TYR A 1 439 ? 69.945  103.444 94.281  1.00 56.60  ? 439 TYR A CE1 1 
ATOM 3135 C CE2 . TYR A 1 439 ? 72.108  103.315 95.287  1.00 56.60  ? 439 TYR A CE2 1 
ATOM 3136 C CZ  . TYR A 1 439 ? 71.009  102.697 94.735  1.00 56.60  ? 439 TYR A CZ  1 
ATOM 3137 O OH  . TYR A 1 439 ? 70.970  101.325 94.643  1.00 56.60  ? 439 TYR A OH  1 
ATOM 3138 N N   . VAL A 1 440 ? 69.361  108.442 92.990  1.00 55.67  ? 440 VAL A N   1 
ATOM 3139 C CA  . VAL A 1 440 ? 68.223  108.460 92.076  1.00 55.67  ? 440 VAL A CA  1 
ATOM 3140 C C   . VAL A 1 440 ? 68.598  109.132 90.760  1.00 55.67  ? 440 VAL A C   1 
ATOM 3141 O O   . VAL A 1 440 ? 68.286  108.621 89.681  1.00 55.67  ? 440 VAL A O   1 
ATOM 3142 C CB  . VAL A 1 440 ? 67.017  109.149 92.744  1.00 55.67  ? 440 VAL A CB  1 
ATOM 3143 C CG1 . VAL A 1 440 ? 65.970  109.541 91.713  1.00 55.67  ? 440 VAL A CG1 1 
ATOM 3144 C CG2 . VAL A 1 440 ? 66.410  108.241 93.801  1.00 55.67  ? 440 VAL A CG2 1 
ATOM 3145 N N   . SER A 1 441 ? 69.289  110.275 90.827  1.00 54.07  ? 441 SER A N   1 
ATOM 3146 C CA  . SER A 1 441 ? 69.638  111.003 89.609  1.00 54.07  ? 441 SER A CA  1 
ATOM 3147 C C   . SER A 1 441 ? 70.627  110.225 88.750  1.00 54.07  ? 441 SER A C   1 
ATOM 3148 O O   . SER A 1 441 ? 70.464  110.139 87.524  1.00 54.07  ? 441 SER A O   1 
ATOM 3149 C CB  . SER A 1 441 ? 70.205  112.375 89.968  1.00 54.07  ? 441 SER A CB  1 
ATOM 3150 O OG  . SER A 1 441 ? 70.747  113.012 88.827  1.00 54.07  ? 441 SER A OG  1 
ATOM 3151 N N   . GLY A 1 442 ? 71.660  109.650 89.373  1.00 52.12  ? 442 GLY A N   1 
ATOM 3152 C CA  . GLY A 1 442 ? 72.625  108.870 88.623  1.00 52.12  ? 442 GLY A CA  1 
ATOM 3153 C C   . GLY A 1 442 ? 72.015  107.637 87.992  1.00 52.12  ? 442 GLY A C   1 
ATOM 3154 O O   . GLY A 1 442 ? 72.279  107.335 86.825  1.00 52.12  ? 442 GLY A O   1 
ATOM 3155 N N   . LEU A 1 443 ? 71.171  106.916 88.740  1.00 54.98  ? 443 LEU A N   1 
ATOM 3156 C CA  . LEU A 1 443 ? 70.526  105.748 88.155  1.00 54.98  ? 443 LEU A CA  1 
ATOM 3157 C C   . LEU A 1 443 ? 69.517  106.124 87.080  1.00 54.98  ? 443 LEU A C   1 
ATOM 3158 O O   . LEU A 1 443 ? 69.382  105.394 86.095  1.00 54.98  ? 443 LEU A O   1 
ATOM 3159 C CB  . LEU A 1 443 ? 69.853  104.905 89.236  1.00 54.98  ? 443 LEU A CB  1 
ATOM 3160 C CG  . LEU A 1 443 ? 70.706  103.725 89.704  1.00 54.98  ? 443 LEU A CG  1 
ATOM 3161 C CD1 . LEU A 1 443 ? 70.008  102.967 90.810  1.00 54.98  ? 443 LEU A CD1 1 
ATOM 3162 C CD2 . LEU A 1 443 ? 71.035  102.802 88.540  1.00 54.98  ? 443 LEU A CD2 1 
ATOM 3163 N N   . PHE A 1 444 ? 68.823  107.255 87.230  1.00 57.12  ? 444 PHE A N   1 
ATOM 3164 C CA  . PHE A 1 444 ? 67.885  107.696 86.204  1.00 57.12  ? 444 PHE A CA  1 
ATOM 3165 C C   . PHE A 1 444 ? 68.609  108.027 84.907  1.00 57.12  ? 444 PHE A C   1 
ATOM 3166 O O   . PHE A 1 444 ? 68.200  107.587 83.825  1.00 57.12  ? 444 PHE A O   1 
ATOM 3167 C CB  . PHE A 1 444 ? 67.096  108.905 86.712  1.00 57.12  ? 444 PHE A CB  1 
ATOM 3168 C CG  . PHE A 1 444 ? 66.289  109.597 85.652  1.00 57.12  ? 444 PHE A CG  1 
ATOM 3169 C CD1 . PHE A 1 444 ? 65.137  109.016 85.149  1.00 57.12  ? 444 PHE A CD1 1 
ATOM 3170 C CD2 . PHE A 1 444 ? 66.676  110.835 85.165  1.00 57.12  ? 444 PHE A CD2 1 
ATOM 3171 C CE1 . PHE A 1 444 ? 64.390  109.654 84.175  1.00 57.12  ? 444 PHE A CE1 1 
ATOM 3172 C CE2 . PHE A 1 444 ? 65.934  111.477 84.190  1.00 57.12  ? 444 PHE A CE2 1 
ATOM 3173 C CZ  . PHE A 1 444 ? 64.790  110.886 83.695  1.00 57.12  ? 444 PHE A CZ  1 
ATOM 3174 N N   . LEU A 1 445 ? 69.704  108.789 85.000  1.00 54.57  ? 445 LEU A N   1 
ATOM 3175 C CA  . LEU A 1 445 ? 70.477  109.118 83.805  1.00 54.57  ? 445 LEU A CA  1 
ATOM 3176 C C   . LEU A 1 445 ? 71.102  107.873 83.186  1.00 54.57  ? 445 LEU A C   1 
ATOM 3177 O O   . LEU A 1 445 ? 71.102  107.717 81.958  1.00 54.57  ? 445 LEU A O   1 
ATOM 3178 C CB  . LEU A 1 445 ? 71.552  110.149 84.141  1.00 54.57  ? 445 LEU A CB  1 
ATOM 3179 C CG  . LEU A 1 445 ? 71.065  111.571 84.425  1.00 54.57  ? 445 LEU A CG  1 
ATOM 3180 C CD1 . LEU A 1 445 ? 72.244  112.514 84.572  1.00 54.57  ? 445 LEU A CD1 1 
ATOM 3181 C CD2 . LEU A 1 445 ? 70.125  112.051 83.332  1.00 54.57  ? 445 LEU A CD2 1 
ATOM 3182 N N   . ARG A 1 446 ? 71.621  106.967 84.019  1.00 55.33  ? 446 ARG A N   1 
ATOM 3183 C CA  . ARG A 1 446 ? 72.257  105.755 83.516  1.00 55.33  ? 446 ARG A CA  1 
ATOM 3184 C C   . ARG A 1 446 ? 71.249  104.847 82.819  1.00 55.33  ? 446 ARG A C   1 
ATOM 3185 O O   . ARG A 1 446 ? 71.546  104.262 81.771  1.00 55.33  ? 446 ARG A O   1 
ATOM 3186 C CB  . ARG A 1 446 ? 72.940  105.022 84.670  1.00 55.33  ? 446 ARG A CB  1 
ATOM 3187 C CG  . ARG A 1 446 ? 73.729  103.799 84.262  1.00 55.33  ? 446 ARG A CG  1 
ATOM 3188 C CD  . ARG A 1 446 ? 74.691  104.131 83.141  1.00 55.33  ? 446 ARG A CD  1 
ATOM 3189 N NE  . ARG A 1 446 ? 75.315  102.933 82.598  1.00 55.33  ? 446 ARG A NE  1 
ATOM 3190 C CZ  . ARG A 1 446 ? 74.821  102.223 81.595  1.00 55.33  ? 446 ARG A CZ  1 
ATOM 3191 N NH1 . ARG A 1 446 ? 73.692  102.564 80.997  1.00 55.33  ? 446 ARG A NH1 1 
ATOM 3192 N NH2 . ARG A 1 446 ? 75.476  101.144 81.182  1.00 55.33  ? 446 ARG A NH2 1 
ATOM 3193 N N   . ILE A 1 447 ? 70.051  104.713 83.392  1.00 60.29  ? 447 ILE A N   1 
ATOM 3194 C CA  . ILE A 1 447 ? 69.028  103.852 82.811  1.00 60.29  ? 447 ILE A CA  1 
ATOM 3195 C C   . ILE A 1 447 ? 68.481  104.460 81.526  1.00 60.29  ? 447 ILE A C   1 
ATOM 3196 O O   . ILE A 1 447 ? 68.324  103.765 80.514  1.00 60.29  ? 447 ILE A O   1 
ATOM 3197 C CB  . ILE A 1 447 ? 67.919  103.587 83.846  1.00 60.29  ? 447 ILE A CB  1 
ATOM 3198 C CG1 . ILE A 1 447 ? 68.362  102.498 84.824  1.00 60.29  ? 447 ILE A CG1 1 
ATOM 3199 C CG2 . ILE A 1 447 ? 66.615  103.190 83.169  1.00 60.29  ? 447 ILE A CG2 1 
ATOM 3200 C CD1 . ILE A 1 447 ? 67.395  102.274 85.962  1.00 60.29  ? 447 ILE A CD1 1 
ATOM 3201 N N   . THR A 1 448 ? 68.199  105.767 81.532  1.00 66.16  ? 448 THR A N   1 
ATOM 3202 C CA  . THR A 1 448 ? 67.674  106.405 80.330  1.00 66.16  ? 448 THR A CA  1 
ATOM 3203 C C   . THR A 1 448 ? 68.724  106.494 79.229  1.00 66.16  ? 448 THR A C   1 
ATOM 3204 O O   . THR A 1 448 ? 68.372  106.663 78.056  1.00 66.16  ? 448 THR A O   1 
ATOM 3205 C CB  . THR A 1 448 ? 67.135  107.796 80.661  1.00 66.16  ? 448 THR A CB  1 
ATOM 3206 O OG1 . THR A 1 448 ? 68.105  108.517 81.430  1.00 66.16  ? 448 THR A OG1 1 
ATOM 3207 C CG2 . THR A 1 448 ? 65.843  107.689 81.453  1.00 66.16  ? 448 THR A CG2 1 
ATOM 3208 N N   . GLY A 1 449 ? 70.008  106.388 79.577  1.00 63.35  ? 449 GLY A N   1 
ATOM 3209 C CA  . GLY A 1 449 ? 71.040  106.360 78.556  1.00 63.35  ? 449 GLY A CA  1 
ATOM 3210 C C   . GLY A 1 449 ? 71.085  105.078 77.749  1.00 63.35  ? 449 GLY A C   1 
ATOM 3211 O O   . GLY A 1 449 ? 71.589  105.089 76.622  1.00 63.35  ? 449 GLY A O   1 
ATOM 3212 N N   . GLY A 1 450 ? 70.582  103.976 78.301  1.00 67.85  ? 450 GLY A N   1 
ATOM 3213 C CA  . GLY A 1 450 ? 70.518  102.720 77.575  1.00 67.85  ? 450 GLY A CA  1 
ATOM 3214 C C   . GLY A 1 450 ? 71.785  101.892 77.642  1.00 67.85  ? 450 GLY A C   1 
ATOM 3215 O O   . GLY A 1 450 ? 72.880  102.404 77.389  1.00 67.85  ? 450 GLY A O   1 
ATOM 3216 N N   . GLU A 1 451 ? 71.652  100.608 77.973  1.00 71.80  ? 451 GLU A N   1 
ATOM 3217 C CA  . GLU A 1 451 ? 72.797  99.708  78.068  1.00 71.80  ? 451 GLU A CA  1 
ATOM 3218 C C   . GLU A 1 451 ? 72.728  98.646  76.980  1.00 71.80  ? 451 GLU A C   1 
ATOM 3219 O O   . GLU A 1 451 ? 71.854  97.766  77.037  1.00 71.80  ? 451 GLU A O   1 
ATOM 3220 C CB  . GLU A 1 451 ? 72.856  99.054  79.450  1.00 71.80  ? 451 GLU A CB  1 
ATOM 3221 C CG  . GLU A 1 451 ? 73.912  97.957  79.611  1.00 71.80  ? 451 GLU A CG  1 
ATOM 3222 C CD  . GLU A 1 451 ? 75.353  98.440  79.460  1.00 71.80  ? 451 GLU A CD  1 
ATOM 3223 O OE1 . GLU A 1 451 ? 75.608  99.662  79.439  1.00 71.80  ? 451 GLU A OE1 1 
ATOM 3224 O OE2 . GLU A 1 451 ? 76.250  97.579  79.372  1.00 71.80  ? 451 GLU A OE2 1 
ATOM 3225 N N   . PRO A 1 452 ? 73.601  98.697  75.968  1.00 74.28  ? 452 PRO A N   1 
ATOM 3226 C CA  . PRO A 1 452 ? 73.550  97.685  74.895  1.00 74.28  ? 452 PRO A CA  1 
ATOM 3227 C C   . PRO A 1 452 ? 73.830  96.260  75.351  1.00 74.28  ? 452 PRO A C   1 
ATOM 3228 O O   . PRO A 1 452 ? 73.284  95.319  74.763  1.00 74.28  ? 452 PRO A O   1 
ATOM 3229 C CB  . PRO A 1 452 ? 74.617  98.184  73.910  1.00 74.28  ? 452 PRO A CB  1 
ATOM 3230 C CG  . PRO A 1 452 ? 74.690  99.655  74.162  1.00 74.28  ? 452 PRO A CG  1 
ATOM 3231 C CD  . PRO A 1 452 ? 74.539  99.785  75.647  1.00 74.28  ? 452 PRO A CD  1 
ATOM 3232 N N   . TYR A 1 453 ? 74.682  96.070  76.366  1.00 65.69  ? 453 TYR A N   1 
ATOM 3233 C CA  . TYR A 1 453 ? 75.042  94.717  76.788  1.00 65.69  ? 453 TYR A CA  1 
ATOM 3234 C C   . TYR A 1 453 ? 73.845  93.973  77.366  1.00 65.69  ? 453 TYR A C   1 
ATOM 3235 O O   . TYR A 1 453 ? 73.683  92.769  77.136  1.00 65.69  ? 453 TYR A O   1 
ATOM 3236 C CB  . TYR A 1 453 ? 76.181  94.759  77.808  1.00 65.69  ? 453 TYR A CB  1 
ATOM 3237 C CG  . TYR A 1 453 ? 77.550  95.014  77.214  1.00 65.69  ? 453 TYR A CG  1 
ATOM 3238 C CD1 . TYR A 1 453 ? 77.971  94.345  76.073  1.00 65.69  ? 453 TYR A CD1 1 
ATOM 3239 C CD2 . TYR A 1 453 ? 78.427  95.915  77.805  1.00 65.69  ? 453 TYR A CD2 1 
ATOM 3240 C CE1 . TYR A 1 453 ? 79.223  94.573  75.532  1.00 65.69  ? 453 TYR A CE1 1 
ATOM 3241 C CE2 . TYR A 1 453 ? 79.679  96.150  77.273  1.00 65.69  ? 453 TYR A CE2 1 
ATOM 3242 C CZ  . TYR A 1 453 ? 80.073  95.477  76.137  1.00 65.69  ? 453 TYR A CZ  1 
ATOM 3243 O OH  . TYR A 1 453 ? 81.320  95.710  75.606  1.00 65.69  ? 453 TYR A OH  1 
ATOM 3244 N N   . LEU A 1 454 ? 72.997  94.669  78.123  1.00 70.97  ? 454 LEU A N   1 
ATOM 3245 C CA  . LEU A 1 454 ? 71.798  94.077  78.697  1.00 70.97  ? 454 LEU A CA  1 
ATOM 3246 C C   . LEU A 1 454 ? 70.574  94.253  77.808  1.00 70.97  ? 454 LEU A C   1 
ATOM 3247 O O   . LEU A 1 454 ? 69.448  94.048  78.279  1.00 70.97  ? 454 LEU A O   1 
ATOM 3248 C CB  . LEU A 1 454 ? 71.532  94.662  80.086  1.00 70.97  ? 454 LEU A CB  1 
ATOM 3249 C CG  . LEU A 1 454 ? 72.601  94.374  81.140  1.00 70.97  ? 454 LEU A CG  1 
ATOM 3250 C CD1 . LEU A 1 454 ? 72.217  94.977  82.480  1.00 70.97  ? 454 LEU A CD1 1 
ATOM 3251 C CD2 . LEU A 1 454 ? 72.824  92.876  81.269  1.00 70.97  ? 454 LEU A CD2 1 
ATOM 3252 N N   . TYR A 1 455 ? 70.777  94.630  76.541  1.00 78.33  ? 455 TYR A N   1 
ATOM 3253 C CA  . TYR A 1 455 ? 69.710  94.751  75.543  1.00 78.33  ? 455 TYR A CA  1 
ATOM 3254 C C   . TYR A 1 455 ? 68.625  95.733  75.984  1.00 78.33  ? 455 TYR A C   1 
ATOM 3255 O O   . TYR A 1 455 ? 67.431  95.493  75.801  1.00 78.33  ? 455 TYR A O   1 
ATOM 3256 C CB  . TYR A 1 455 ? 69.107  93.382  75.209  1.00 78.33  ? 455 TYR A CB  1 
ATOM 3257 C CG  . TYR A 1 455 ? 70.138  92.289  75.019  1.00 78.33  ? 455 TYR A CG  1 
ATOM 3258 C CD1 . TYR A 1 455 ? 71.189  92.446  74.124  1.00 78.33  ? 455 TYR A CD1 1 
ATOM 3259 C CD2 . TYR A 1 455 ? 70.060  91.103  75.737  1.00 78.33  ? 455 TYR A CD2 1 
ATOM 3260 C CE1 . TYR A 1 455 ? 72.134  91.451  73.949  1.00 78.33  ? 455 TYR A CE1 1 
ATOM 3261 C CE2 . TYR A 1 455 ? 71.000  90.102  75.568  1.00 78.33  ? 455 TYR A CE2 1 
ATOM 3262 C CZ  . TYR A 1 455 ? 72.034  90.282  74.673  1.00 78.33  ? 455 TYR A CZ  1 
ATOM 3263 O OH  . TYR A 1 455 ? 72.971  89.289  74.502  1.00 78.33  ? 455 TYR A OH  1 
ATOM 3264 N N   . LEU A 1 456 ? 69.046  96.851  76.567  1.00 80.00  ? 456 LEU A N   1 
ATOM 3265 C CA  . LEU A 1 456 ? 68.136  97.886  77.038  1.00 80.00  ? 456 LEU A CA  1 
ATOM 3266 C C   . LEU A 1 456 ? 68.169  99.070  76.081  1.00 80.00  ? 456 LEU A C   1 
ATOM 3267 O O   . LEU A 1 456 ? 69.246  99.580  75.752  1.00 80.00  ? 456 LEU A O   1 
ATOM 3268 C CB  . LEU A 1 456 ? 68.510  98.334  78.451  1.00 80.00  ? 456 LEU A CB  1 
ATOM 3269 C CG  . LEU A 1 456 ? 67.599  99.374  79.106  1.00 80.00  ? 456 LEU A CG  1 
ATOM 3270 C CD1 . LEU A 1 456 ? 66.194  98.823  79.286  1.00 80.00  ? 456 LEU A CD1 1 
ATOM 3271 C CD2 . LEU A 1 456 ? 68.175  99.823  80.440  1.00 80.00  ? 456 LEU A CD2 1 
ATOM 3272 N N   . GLN A 1 457 ? 66.992  99.500  75.635  1.00 85.69  ? 457 GLN A N   1 
ATOM 3273 C CA  . GLN A 1 457 ? 66.909  100.627 74.722  1.00 85.69  ? 457 GLN A CA  1 
ATOM 3274 C C   . GLN A 1 457 ? 67.096  101.944 75.475  1.00 85.69  ? 457 GLN A C   1 
ATOM 3275 O O   . GLN A 1 457 ? 66.748  102.050 76.654  1.00 85.69  ? 457 GLN A O   1 
ATOM 3276 C CB  . GLN A 1 457 ? 65.564  100.631 74.001  1.00 85.69  ? 457 GLN A CB  1 
ATOM 3277 C CG  . GLN A 1 457 ? 65.543  99.830  72.709  1.00 85.69  ? 457 GLN A CG  1 
ATOM 3278 C CD  . GLN A 1 457 ? 64.269  100.044 71.913  1.00 85.69  ? 457 GLN A CD  1 
ATOM 3279 O OE1 . GLN A 1 457 ? 63.908  101.176 71.590  1.00 85.69  ? 457 GLN A OE1 1 
ATOM 3280 N NE2 . GLN A 1 457 ? 63.580  98.955  71.593  1.00 85.69  ? 457 GLN A NE2 1 
ATOM 3281 N N   . PRO A 1 458 ? 67.652  102.964 74.815  1.00 82.39  ? 458 PRO A N   1 
ATOM 3282 C CA  . PRO A 1 458 ? 67.768  104.280 75.456  1.00 82.39  ? 458 PRO A CA  1 
ATOM 3283 C C   . PRO A 1 458 ? 66.503  105.114 75.322  1.00 82.39  ? 458 PRO A C   1 
ATOM 3284 O O   . PRO A 1 458 ? 65.855  105.108 74.271  1.00 82.39  ? 458 PRO A O   1 
ATOM 3285 C CB  . PRO A 1 458 ? 68.941  104.925 74.711  1.00 82.39  ? 458 PRO A CB  1 
ATOM 3286 C CG  . PRO A 1 458 ? 68.897  104.309 73.364  1.00 82.39  ? 458 PRO A CG  1 
ATOM 3287 C CD  . PRO A 1 458 ? 68.405  102.898 73.550  1.00 82.39  ? 458 PRO A CD  1 
ATOM 3288 N N   . LEU A 1 459 ? 66.140  105.830 76.386  1.00 83.05  ? 459 LEU A N   1 
ATOM 3289 C CA  . LEU A 1 459 ? 64.989  106.723 76.351  1.00 83.05  ? 459 LEU A CA  1 
ATOM 3290 C C   . LEU A 1 459 ? 65.378  108.157 76.010  1.00 83.05  ? 459 LEU A C   1 
ATOM 3291 O O   . LEU A 1 459 ? 64.759  108.774 75.137  1.00 83.05  ? 459 LEU A O   1 
ATOM 3292 C CB  . LEU A 1 459 ? 64.252  106.685 77.692  1.00 83.05  ? 459 LEU A CB  1 
ATOM 3293 C CG  . LEU A 1 459 ? 63.600  105.345 78.035  1.00 83.05  ? 459 LEU A CG  1 
ATOM 3294 C CD1 . LEU A 1 459 ? 63.006  105.372 79.435  1.00 83.05  ? 459 LEU A CD1 1 
ATOM 3295 C CD2 . LEU A 1 459 ? 62.541  104.989 77.004  1.00 83.05  ? 459 LEU A CD2 1 
ATOM 3296 N N   . ILE A 1 460 ? 66.389  108.701 76.680  1.00 79.81  ? 460 ILE A N   1 
ATOM 3297 C CA  . ILE A 1 460 ? 66.895  110.037 76.388  1.00 79.81  ? 460 ILE A CA  1 
ATOM 3298 C C   . ILE A 1 460 ? 68.004  109.922 75.354  1.00 79.81  ? 460 ILE A C   1 
ATOM 3299 O O   . ILE A 1 460 ? 68.925  109.110 75.499  1.00 79.81  ? 460 ILE A O   1 
ATOM 3300 C CB  . ILE A 1 460 ? 67.395  110.730 77.669  1.00 79.81  ? 460 ILE A CB  1 
ATOM 3301 C CG1 . ILE A 1 460 ? 66.276  110.806 78.708  1.00 79.81  ? 460 ILE A CG1 1 
ATOM 3302 C CG2 . ILE A 1 460 ? 67.929  112.121 77.355  1.00 79.81  ? 460 ILE A CG2 1 
ATOM 3303 C CD1 . ILE A 1 460 ? 66.681  111.502 79.988  1.00 79.81  ? 460 ILE A CD1 1 
ATOM 3304 N N   . PHE A 1 461 ? 67.918  110.734 74.304  1.00 82.28  ? 461 PHE A N   1 
ATOM 3305 C CA  . PHE A 1 461 ? 68.865  110.690 73.197  1.00 82.28  ? 461 PHE A CA  1 
ATOM 3306 C C   . PHE A 1 461 ? 69.730  111.940 73.227  1.00 82.28  ? 461 PHE A C   1 
ATOM 3307 O O   . PHE A 1 461 ? 69.252  113.038 72.922  1.00 82.28  ? 461 PHE A O   1 
ATOM 3308 C CB  . PHE A 1 461 ? 68.141  110.568 71.853  1.00 82.28  ? 461 PHE A CB  1 
ATOM 3309 C CG  . PHE A 1 461 ? 67.332  109.309 71.709  1.00 82.28  ? 461 PHE A CG  1 
ATOM 3310 C CD1 . PHE A 1 461 ? 66.033  109.240 72.187  1.00 82.28  ? 461 PHE A CD1 1 
ATOM 3311 C CD2 . PHE A 1 461 ? 67.876  108.190 71.102  1.00 82.28  ? 461 PHE A CD2 1 
ATOM 3312 C CE1 . PHE A 1 461 ? 65.291  108.080 72.056  1.00 82.28  ? 461 PHE A CE1 1 
ATOM 3313 C CE2 . PHE A 1 461 ? 67.140  107.029 70.970  1.00 82.28  ? 461 PHE A CE2 1 
ATOM 3314 C CZ  . PHE A 1 461 ? 65.847  106.973 71.447  1.00 82.28  ? 461 PHE A CZ  1 
ATOM 3315 N N   . TYR A 1 462 ? 70.991  111.770 73.592  1.00 73.29  ? 462 TYR A N   1 
ATOM 3316 C CA  . TYR A 1 462 ? 71.988  112.827 73.522  1.00 73.29  ? 462 TYR A CA  1 
ATOM 3317 C C   . TYR A 1 462 ? 72.489  112.957 72.092  1.00 73.29  ? 462 TYR A C   1 
ATOM 3318 O O   . TYR A 1 462 ? 72.313  112.046 71.279  1.00 73.29  ? 462 TYR A O   1 
ATOM 3319 C CB  . TYR A 1 462 ? 73.133  112.519 74.489  1.00 73.29  ? 462 TYR A CB  1 
ATOM 3320 C CG  . TYR A 1 462 ? 72.708  112.320 75.930  1.00 73.29  ? 462 TYR A CG  1 
ATOM 3321 C CD1 . TYR A 1 462 ? 72.324  111.069 76.397  1.00 73.29  ? 462 TYR A CD1 1 
ATOM 3322 C CD2 . TYR A 1 462 ? 72.694  113.383 76.822  1.00 73.29  ? 462 TYR A CD2 1 
ATOM 3323 C CE1 . TYR A 1 462 ? 71.937  110.884 77.710  1.00 73.29  ? 462 TYR A CE1 1 
ATOM 3324 C CE2 . TYR A 1 462 ? 72.309  113.208 78.137  1.00 73.29  ? 462 TYR A CE2 1 
ATOM 3325 C CZ  . TYR A 1 462 ? 71.932  111.956 78.574  1.00 73.29  ? 462 TYR A CZ  1 
ATOM 3326 O OH  . TYR A 1 462 ? 71.547  111.775 79.881  1.00 73.29  ? 462 TYR A OH  1 
ATOM 3327 N N   . PRO A 1 463 ? 73.085  114.099 71.732  1.00 79.77  ? 463 PRO A N   1 
ATOM 3328 C CA  . PRO A 1 463 ? 73.613  114.251 70.369  1.00 79.77  ? 463 PRO A CA  1 
ATOM 3329 C C   . PRO A 1 463 ? 74.695  113.228 70.049  1.00 79.77  ? 463 PRO A C   1 
ATOM 3330 O O   . PRO A 1 463 ? 75.512  112.869 70.899  1.00 79.77  ? 463 PRO A O   1 
ATOM 3331 C CB  . PRO A 1 463 ? 74.172  115.677 70.364  1.00 79.77  ? 463 PRO A CB  1 
ATOM 3332 C CG  . PRO A 1 463 ? 73.379  116.388 71.393  1.00 79.77  ? 463 PRO A CG  1 
ATOM 3333 C CD  . PRO A 1 463 ? 73.105  115.378 72.466  1.00 79.77  ? 463 PRO A CD  1 
ATOM 3334 N N   . GLY A 1 464 ? 74.689  112.761 68.802  1.00 81.54  ? 464 GLY A N   1 
ATOM 3335 C CA  . GLY A 1 464 ? 75.637  111.764 68.352  1.00 81.54  ? 464 GLY A CA  1 
ATOM 3336 C C   . GLY A 1 464 ? 75.174  110.330 68.458  1.00 81.54  ? 464 GLY A C   1 
ATOM 3337 O O   . GLY A 1 464 ? 75.972  109.421 68.205  1.00 81.54  ? 464 GLY A O   1 
ATOM 3338 N N   . TYR A 1 465 ? 73.915  110.093 68.822  1.00 86.60  ? 465 TYR A N   1 
ATOM 3339 C CA  . TYR A 1 465 ? 73.418  108.730 68.952  1.00 86.60  ? 465 TYR A CA  1 
ATOM 3340 C C   . TYR A 1 465 ? 73.288  108.069 67.584  1.00 86.60  ? 465 TYR A C   1 
ATOM 3341 O O   . TYR A 1 465 ? 72.910  108.707 66.599  1.00 86.60  ? 465 TYR A O   1 
ATOM 3342 C CB  . TYR A 1 465 ? 72.077  108.729 69.700  1.00 86.60  ? 465 TYR A CB  1 
ATOM 3343 C CG  . TYR A 1 465 ? 70.863  109.145 68.888  1.00 86.60  ? 465 TYR A CG  1 
ATOM 3344 C CD1 . TYR A 1 465 ? 70.102  108.209 68.194  1.00 86.60  ? 465 TYR A CD1 1 
ATOM 3345 C CD2 . TYR A 1 465 ? 70.478  110.478 68.820  1.00 86.60  ? 465 TYR A CD2 1 
ATOM 3346 C CE1 . TYR A 1 465 ? 68.998  108.589 67.456  1.00 86.60  ? 465 TYR A CE1 1 
ATOM 3347 C CE2 . TYR A 1 465 ? 69.375  110.867 68.084  1.00 86.60  ? 465 TYR A CE2 1 
ATOM 3348 C CZ  . TYR A 1 465 ? 68.639  109.919 67.405  1.00 86.60  ? 465 TYR A CZ  1 
ATOM 3349 O OH  . TYR A 1 465 ? 67.539  110.301 66.671  1.00 86.60  ? 465 TYR A OH  1 
ATOM 3350 N N   . TYR A 1 466 ? 73.612  106.780 67.529  1.00 87.95  ? 466 TYR A N   1 
ATOM 3351 C CA  . TYR A 1 466 ? 73.557  106.002 66.302  1.00 87.95  ? 466 TYR A CA  1 
ATOM 3352 C C   . TYR A 1 466 ? 73.033  104.609 66.613  1.00 87.95  ? 466 TYR A C   1 
ATOM 3353 O O   . TYR A 1 466 ? 73.304  104.070 67.693  1.00 87.95  ? 466 TYR A O   1 
ATOM 3354 C CB  . TYR A 1 466 ? 74.942  105.908 65.636  1.00 87.95  ? 466 TYR A CB  1 
ATOM 3355 C CG  . TYR A 1 466 ? 75.992  105.190 66.461  1.00 87.95  ? 466 TYR A CG  1 
ATOM 3356 C CD1 . TYR A 1 466 ? 76.215  103.825 66.312  1.00 87.95  ? 466 TYR A CD1 1 
ATOM 3357 C CD2 . TYR A 1 466 ? 76.755  105.877 67.395  1.00 87.95  ? 466 TYR A CD2 1 
ATOM 3358 C CE1 . TYR A 1 466 ? 77.169  103.170 67.065  1.00 87.95  ? 466 TYR A CE1 1 
ATOM 3359 C CE2 . TYR A 1 466 ? 77.712  105.229 68.153  1.00 87.95  ? 466 TYR A CE2 1 
ATOM 3360 C CZ  . TYR A 1 466 ? 77.915  103.877 67.982  1.00 87.95  ? 466 TYR A CZ  1 
ATOM 3361 O OH  . TYR A 1 466 ? 78.866  103.229 68.736  1.00 87.95  ? 466 TYR A OH  1 
ATOM 3362 N N   . PRO A 1 467 ? 72.290  103.996 65.687  1.00 93.55  ? 467 PRO A N   1 
ATOM 3363 C CA  . PRO A 1 467 ? 71.792  102.635 65.930  1.00 93.55  ? 467 PRO A CA  1 
ATOM 3364 C C   . PRO A 1 467 ? 72.754  101.556 65.455  1.00 93.55  ? 467 PRO A C   1 
ATOM 3365 O O   . PRO A 1 467 ? 73.343  101.666 64.375  1.00 93.55  ? 467 PRO A O   1 
ATOM 3366 C CB  . PRO A 1 467 ? 70.478  102.608 65.142  1.00 93.55  ? 467 PRO A CB  1 
ATOM 3367 C CG  . PRO A 1 467 ? 70.709  103.561 64.001  1.00 93.55  ? 467 PRO A CG  1 
ATOM 3368 C CD  . PRO A 1 467 ? 71.778  104.552 64.422  1.00 93.55  ? 467 PRO A CD  1 
ATOM 3369 N N   . ASP A 1 468 ? 72.922  100.508 66.257  1.00 95.68  ? 468 ASP A N   1 
ATOM 3370 C CA  . ASP A 1 468 ? 73.803  99.403  65.912  1.00 95.68  ? 468 ASP A CA  1 
ATOM 3371 C C   . ASP A 1 468 ? 73.013  98.308  65.191  1.00 95.68  ? 468 ASP A C   1 
ATOM 3372 O O   . ASP A 1 468 ? 71.890  98.524  64.727  1.00 95.68  ? 468 ASP A O   1 
ATOM 3373 C CB  . ASP A 1 468 ? 74.526  98.891  67.161  1.00 95.68  ? 468 ASP A CB  1 
ATOM 3374 C CG  . ASP A 1 468 ? 73.579  98.339  68.222  1.00 95.68  ? 468 ASP A CG  1 
ATOM 3375 O OD1 . ASP A 1 468 ? 72.344  98.402  68.049  1.00 95.68  ? 468 ASP A OD1 1 
ATOM 3376 O OD2 . ASP A 1 468 ? 74.085  97.833  69.246  1.00 95.68  ? 468 ASP A OD2 1 
ATOM 3377 N N   . ASP A 1 469 ? 73.613  97.119  65.076  1.00 98.51  ? 469 ASP A N   1 
ATOM 3378 C CA  . ASP A 1 469 ? 72.948  96.001  64.412  1.00 98.51  ? 469 ASP A CA  1 
ATOM 3379 C C   . ASP A 1 469 ? 71.697  95.564  65.166  1.00 98.51  ? 469 ASP A C   1 
ATOM 3380 O O   . ASP A 1 469 ? 70.673  95.243  64.551  1.00 98.51  ? 469 ASP A O   1 
ATOM 3381 C CB  . ASP A 1 469 ? 73.919  94.829  64.266  1.00 98.51  ? 469 ASP A CB  1 
ATOM 3382 C CG  . ASP A 1 469 ? 75.065  95.135  63.324  1.00 98.51  ? 469 ASP A CG  1 
ATOM 3383 O OD1 . ASP A 1 469 ? 74.983  96.146  62.596  1.00 98.51  ? 469 ASP A OD1 1 
ATOM 3384 O OD2 . ASP A 1 469 ? 76.049  94.366  63.313  1.00 98.51  ? 469 ASP A OD2 1 
ATOM 3385 N N   . ASN A 1 470 ? 71.760  95.546  66.499  1.00 99.44  ? 470 ASN A N   1 
ATOM 3386 C CA  . ASN A 1 470 ? 70.619  95.117  67.302  1.00 99.44  ? 470 ASN A CA  1 
ATOM 3387 C C   . ASN A 1 470 ? 69.485  96.136  67.307  1.00 99.44  ? 470 ASN A C   1 
ATOM 3388 O O   . ASN A 1 470 ? 68.398  95.828  67.808  1.00 99.44  ? 470 ASN A O   1 
ATOM 3389 C CB  . ASN A 1 470 ? 71.063  94.837  68.738  1.00 99.44  ? 470 ASN A CB  1 
ATOM 3390 C CG  . ASN A 1 470 ? 71.962  93.622  68.844  1.00 99.44  ? 470 ASN A CG  1 
ATOM 3391 O OD1 . ASN A 1 470 ? 72.570  93.199  67.861  1.00 99.44  ? 470 ASN A OD1 1 
ATOM 3392 N ND2 . ASN A 1 470 ? 72.051  93.054  70.041  1.00 99.44  ? 470 ASN A ND2 1 
ATOM 3393 N N   . GLY A 1 471 ? 69.707  97.331  66.769  1.00 97.26  ? 471 GLY A N   1 
ATOM 3394 C CA  . GLY A 1 471 ? 68.718  98.385  66.819  1.00 97.26  ? 471 GLY A CA  1 
ATOM 3395 C C   . GLY A 1 471 ? 68.747  99.223  68.075  1.00 97.26  ? 471 GLY A C   1 
ATOM 3396 O O   . GLY A 1 471 ? 67.884  100.093 68.240  1.00 97.26  ? 471 GLY A O   1 
ATOM 3397 N N   . ILE A 1 472 ? 69.708  98.992  68.962  1.00 94.34  ? 472 ILE A N   1 
ATOM 3398 C CA  . ILE A 1 472 ? 69.852  99.773  70.184  1.00 94.34  ? 472 ILE A CA  1 
ATOM 3399 C C   . ILE A 1 472 ? 70.721  100.982 69.873  1.00 94.34  ? 472 ILE A C   1 
ATOM 3400 O O   . ILE A 1 472 ? 71.862  100.837 69.420  1.00 94.34  ? 472 ILE A O   1 
ATOM 3401 C CB  . ILE A 1 472 ? 70.463  98.930  71.312  1.00 94.34  ? 472 ILE A CB  1 
ATOM 3402 C CG1 . ILE A 1 472 ? 69.593  97.706  71.591  1.00 94.34  ? 472 ILE A CG1 1 
ATOM 3403 C CG2 . ILE A 1 472 ? 70.629  99.767  72.570  1.00 94.34  ? 472 ILE A CG2 1 
ATOM 3404 C CD1 . ILE A 1 472 ? 70.281  96.658  72.425  1.00 94.34  ? 472 ILE A CD1 1 
ATOM 3405 N N   . TYR A 1 473 ? 70.186  102.174 70.111  1.00 92.96  ? 473 TYR A N   1 
ATOM 3406 C CA  . TYR A 1 473 ? 70.929  103.392 69.823  1.00 92.96  ? 473 TYR A CA  1 
ATOM 3407 C C   . TYR A 1 473 ? 72.085  103.547 70.803  1.00 92.96  ? 473 TYR A C   1 
ATOM 3408 O O   . TYR A 1 473 ? 71.893  103.509 72.022  1.00 92.96  ? 473 TYR A O   1 
ATOM 3409 C CB  . TYR A 1 473 ? 70.000  104.602 69.887  1.00 92.96  ? 473 TYR A CB  1 
ATOM 3410 C CG  . TYR A 1 473 ? 68.845  104.528 68.915  1.00 92.96  ? 473 TYR A CG  1 
ATOM 3411 C CD1 . TYR A 1 473 ? 67.608  104.036 69.311  1.00 92.96  ? 473 TYR A CD1 1 
ATOM 3412 C CD2 . TYR A 1 473 ? 68.993  104.945 67.598  1.00 92.96  ? 473 TYR A CD2 1 
ATOM 3413 C CE1 . TYR A 1 473 ? 66.550  103.966 68.426  1.00 92.96  ? 473 TYR A CE1 1 
ATOM 3414 C CE2 . TYR A 1 473 ? 67.940  104.879 66.705  1.00 92.96  ? 473 TYR A CE2 1 
ATOM 3415 C CZ  . TYR A 1 473 ? 66.722  104.389 67.125  1.00 92.96  ? 473 TYR A CZ  1 
ATOM 3416 O OH  . TYR A 1 473 ? 65.671  104.320 66.240  1.00 92.96  ? 473 TYR A OH  1 
ATOM 3417 N N   . ASN A 1 474 ? 73.288  103.723 70.265  1.00 84.77  ? 474 ASN A N   1 
ATOM 3418 C CA  . ASN A 1 474 ? 74.506  103.836 71.056  1.00 84.77  ? 474 ASN A CA  1 
ATOM 3419 C C   . ASN A 1 474 ? 74.919  105.298 71.135  1.00 84.77  ? 474 ASN A C   1 
ATOM 3420 O O   . ASN A 1 474 ? 74.924  106.002 70.120  1.00 84.77  ? 474 ASN A O   1 
ATOM 3421 C CB  . ASN A 1 474 ? 75.632  102.997 70.451  1.00 84.77  ? 474 ASN A CB  1 
ATOM 3422 C CG  . ASN A 1 474 ? 75.549  101.537 70.848  1.00 84.77  ? 474 ASN A CG  1 
ATOM 3423 O OD1 . ASN A 1 474 ? 74.663  100.809 70.403  1.00 84.77  ? 474 ASN A OD1 1 
ATOM 3424 N ND2 . ASN A 1 474 ? 76.480  101.100 71.687  1.00 84.77  ? 474 ASN A ND2 1 
ATOM 3425 N N   . GLN A 1 475 ? 75.266  105.747 72.337  1.00 75.24  ? 475 GLN A N   1 
ATOM 3426 C CA  . GLN A 1 475 ? 75.574  107.149 72.584  1.00 75.24  ? 475 GLN A CA  1 
ATOM 3427 C C   . GLN A 1 475 ? 77.059  107.418 72.378  1.00 75.24  ? 475 GLN A C   1 
ATOM 3428 O O   . GLN A 1 475 ? 77.905  106.764 72.996  1.00 75.24  ? 475 GLN A O   1 
ATOM 3429 C CB  . GLN A 1 475 ? 75.169  107.535 74.007  1.00 75.24  ? 475 GLN A CB  1 
ATOM 3430 C CG  . GLN A 1 475 ? 73.684  107.406 74.296  1.00 75.24  ? 475 GLN A CG  1 
ATOM 3431 C CD  . GLN A 1 475 ? 72.852  108.376 73.487  1.00 75.24  ? 475 GLN A CD  1 
ATOM 3432 O OE1 . GLN A 1 475 ? 73.252  109.517 73.268  1.00 75.24  ? 475 GLN A OE1 1 
ATOM 3433 N NE2 . GLN A 1 475 ? 71.684  107.928 73.042  1.00 75.24  ? 475 GLN A NE2 1 
ATOM 3434 N N   . LYS A 1 476 ? 77.373  108.379 71.508  1.00 70.62  ? 476 LYS A N   1 
ATOM 3435 C CA  . LYS A 1 476 ? 78.728  108.905 71.412  1.00 70.62  ? 476 LYS A CA  1 
ATOM 3436 C C   . LYS A 1 476 ? 79.011  109.980 72.449  1.00 70.62  ? 476 LYS A C   1 
ATOM 3437 O O   . LYS A 1 476 ? 80.179  110.310 72.676  1.00 70.62  ? 476 LYS A O   1 
ATOM 3438 C CB  . LYS A 1 476 ? 78.992  109.479 70.016  1.00 70.62  ? 476 LYS A CB  1 
ATOM 3439 C CG  . LYS A 1 476 ? 79.055  108.449 68.905  1.00 70.62  ? 476 LYS A CG  1 
ATOM 3440 C CD  . LYS A 1 476 ? 79.392  109.107 67.576  1.00 70.62  ? 476 LYS A CD  1 
ATOM 3441 C CE  . LYS A 1 476 ? 79.382  108.103 66.434  1.00 70.62  ? 476 LYS A CE  1 
ATOM 3442 N NZ  . LYS A 1 476 ? 80.484  107.110 66.550  1.00 70.62  ? 476 LYS A NZ  1 
ATOM 3443 N N   . PHE A 1 477 ? 77.978  110.532 73.071  1.00 60.89  ? 477 PHE A N   1 
ATOM 3444 C CA  . PHE A 1 477 ? 78.123  111.507 74.136  1.00 60.89  ? 477 PHE A CA  1 
ATOM 3445 C C   . PHE A 1 477 ? 78.568  110.815 75.422  1.00 60.89  ? 477 PHE A C   1 
ATOM 3446 O O   . PHE A 1 477 ? 78.138  109.695 75.712  1.00 60.89  ? 477 PHE A O   1 
ATOM 3447 C CB  . PHE A 1 477 ? 76.800  112.234 74.363  1.00 60.89  ? 477 PHE A CB  1 
ATOM 3448 C CG  . PHE A 1 477 ? 76.903  113.424 75.273  1.00 60.89  ? 477 PHE A CG  1 
ATOM 3449 C CD1 . PHE A 1 477 ? 77.339  114.646 74.791  1.00 60.89  ? 477 PHE A CD1 1 
ATOM 3450 C CD2 . PHE A 1 477 ? 76.558  113.321 76.611  1.00 60.89  ? 477 PHE A CD2 1 
ATOM 3451 C CE1 . PHE A 1 477 ? 77.434  115.743 75.626  1.00 60.89  ? 477 PHE A CE1 1 
ATOM 3452 C CE2 . PHE A 1 477 ? 76.650  114.413 77.450  1.00 60.89  ? 477 PHE A CE2 1 
ATOM 3453 C CZ  . PHE A 1 477 ? 77.088  115.626 76.957  1.00 60.89  ? 477 PHE A CZ  1 
ATOM 3454 N N   . PRO A 1 478 ? 79.434  111.455 76.212  1.00 51.27  ? 478 PRO A N   1 
ATOM 3455 C CA  . PRO A 1 478 ? 79.851  110.855 77.499  1.00 51.27  ? 478 PRO A CA  1 
ATOM 3456 C C   . PRO A 1 478 ? 78.760  110.941 78.559  1.00 51.27  ? 478 PRO A C   1 
ATOM 3457 O O   . PRO A 1 478 ? 78.865  111.646 79.566  1.00 51.27  ? 478 PRO A O   1 
ATOM 3458 C CB  . PRO A 1 478 ? 81.091  111.680 77.855  1.00 51.27  ? 478 PRO A CB  1 
ATOM 3459 C CG  . PRO A 1 478 ? 80.825  113.009 77.245  1.00 51.27  ? 478 PRO A CG  1 
ATOM 3460 C CD  . PRO A 1 478 ? 80.173  112.698 75.928  1.00 51.27  ? 478 PRO A CD  1 
ATOM 3461 N N   . PHE A 1 479 ? 77.674  110.195 78.337  1.00 49.84  ? 479 PHE A N   1 
ATOM 3462 C CA  . PHE A 1 479 ? 76.533  110.263 79.243  1.00 49.84  ? 479 PHE A CA  1 
ATOM 3463 C C   . PHE A 1 479 ? 76.813  109.558 80.564  1.00 49.84  ? 479 PHE A C   1 
ATOM 3464 O O   . PHE A 1 479 ? 76.181  109.878 81.574  1.00 49.84  ? 479 PHE A O   1 
ATOM 3465 C CB  . PHE A 1 479 ? 75.285  109.685 78.568  1.00 49.84  ? 479 PHE A CB  1 
ATOM 3466 C CG  . PHE A 1 479 ? 75.229  108.181 78.554  1.00 49.84  ? 479 PHE A CG  1 
ATOM 3467 C CD1 . PHE A 1 479 ? 75.884  107.463 77.569  1.00 49.84  ? 479 PHE A CD1 1 
ATOM 3468 C CD2 . PHE A 1 479 ? 74.497  107.487 79.506  1.00 49.84  ? 479 PHE A CD2 1 
ATOM 3469 C CE1 . PHE A 1 479 ? 75.831  106.084 77.546  1.00 49.84  ? 479 PHE A CE1 1 
ATOM 3470 C CE2 . PHE A 1 479 ? 74.446  106.108 79.489  1.00 49.84  ? 479 PHE A CE2 1 
ATOM 3471 C CZ  . PHE A 1 479 ? 75.109  105.407 78.505  1.00 49.84  ? 479 PHE A CZ  1 
ATOM 3472 N N   . LYS A 1 480 ? 77.738  108.598 80.582  1.00 47.29  ? 480 LYS A N   1 
ATOM 3473 C CA  . LYS A 1 480 ? 78.060  107.916 81.832  1.00 47.29  ? 480 LYS A CA  1 
ATOM 3474 C C   . LYS A 1 480 ? 78.904  108.798 82.746  1.00 47.29  ? 480 LYS A C   1 
ATOM 3475 O O   . LYS A 1 480 ? 78.655  108.867 83.955  1.00 47.29  ? 480 LYS A O   1 
ATOM 3476 C CB  . LYS A 1 480 ? 78.770  106.598 81.533  1.00 47.29  ? 480 LYS A CB  1 
ATOM 3477 C CG  . LYS A 1 480 ? 77.896  105.610 80.789  1.00 47.29  ? 480 LYS A CG  1 
ATOM 3478 C CD  . LYS A 1 480 ? 78.597  104.286 80.596  1.00 47.29  ? 480 LYS A CD  1 
ATOM 3479 C CE  . LYS A 1 480 ? 78.147  103.601 79.321  1.00 47.29  ? 480 LYS A CE  1 
ATOM 3480 N NZ  . LYS A 1 480 ? 78.363  102.132 79.386  1.00 47.29  ? 480 LYS A NZ  1 
ATOM 3481 N N   . THR A 1 481 ? 79.901  109.487 82.184  1.00 46.05  ? 481 THR A N   1 
ATOM 3482 C CA  . THR A 1 481 ? 80.665  110.456 82.964  1.00 46.05  ? 481 THR A CA  1 
ATOM 3483 C C   . THR A 1 481 ? 79.783  111.620 83.396  1.00 46.05  ? 481 THR A C   1 
ATOM 3484 O O   . THR A 1 481 ? 79.909  112.123 84.520  1.00 46.05  ? 481 THR A O   1 
ATOM 3485 C CB  . THR A 1 481 ? 81.862  110.952 82.152  1.00 46.05  ? 481 THR A CB  1 
ATOM 3486 O OG1 . THR A 1 481 ? 82.683  109.836 81.790  1.00 46.05  ? 481 THR A OG1 1 
ATOM 3487 C CG2 . THR A 1 481 ? 82.697  111.934 82.959  1.00 46.05  ? 481 THR A CG2 1 
ATOM 3488 N N   . LEU A 1 482 ? 78.876  112.052 82.515  1.00 46.09  ? 482 LEU A N   1 
ATOM 3489 C CA  . LEU A 1 482 ? 77.913  113.085 82.877  1.00 46.09  ? 482 LEU A CA  1 
ATOM 3490 C C   . LEU A 1 482 ? 77.009  112.622 84.011  1.00 46.09  ? 482 LEU A C   1 
ATOM 3491 O O   . LEU A 1 482 ? 76.704  113.395 84.920  1.00 46.09  ? 482 LEU A O   1 
ATOM 3492 C CB  . LEU A 1 482 ? 77.083  113.482 81.656  1.00 46.09  ? 482 LEU A CB  1 
ATOM 3493 C CG  . LEU A 1 482 ? 75.910  114.434 81.898  1.00 46.09  ? 482 LEU A CG  1 
ATOM 3494 C CD1 . LEU A 1 482 ? 76.402  115.838 82.201  1.00 46.09  ? 482 LEU A CD1 1 
ATOM 3495 C CD2 . LEU A 1 482 ? 74.967  114.435 80.707  1.00 46.09  ? 482 LEU A CD2 1 
ATOM 3496 N N   . ALA A 1 483 ? 76.580  111.358 83.977  1.00 44.75  ? 483 ALA A N   1 
ATOM 3497 C CA  . ALA A 1 483 ? 75.759  110.814 85.054  1.00 44.75  ? 483 ALA A CA  1 
ATOM 3498 C C   . ALA A 1 483 ? 76.530  110.752 86.365  1.00 44.75  ? 483 ALA A C   1 
ATOM 3499 O O   . ALA A 1 483 ? 75.978  111.046 87.429  1.00 44.75  ? 483 ALA A O   1 
ATOM 3500 C CB  . ALA A 1 483 ? 75.244  109.427 84.671  1.00 44.75  ? 483 ALA A CB  1 
ATOM 3501 N N   . MET A 1 484 ? 77.809  110.369 86.307  1.00 42.94  ? 484 MET A N   1 
ATOM 3502 C CA  . MET A 1 484 ? 78.631  110.316 87.514  1.00 42.94  ? 484 MET A CA  1 
ATOM 3503 C C   . MET A 1 484 ? 78.805  111.704 88.122  1.00 42.94  ? 484 MET A C   1 
ATOM 3504 O O   . MET A 1 484 ? 78.623  111.893 89.333  1.00 42.94  ? 484 MET A O   1 
ATOM 3505 C CB  . MET A 1 484 ? 79.992  109.694 87.189  1.00 42.94  ? 484 MET A CB  1 
ATOM 3506 C CG  . MET A 1 484 ? 80.832  109.330 88.407  1.00 42.94  ? 484 MET A CG  1 
ATOM 3507 S SD  . MET A 1 484 ? 81.880  110.631 89.098  1.00 42.94  ? 484 MET A SD  1 
ATOM 3508 C CE  . MET A 1 484 ? 82.695  111.258 87.637  1.00 42.94  ? 484 MET A CE  1 
ATOM 3509 N N   . VAL A 1 485 ? 79.151  112.691 87.289  1.00 45.34  ? 485 VAL A N   1 
ATOM 3510 C CA  . VAL A 1 485 ? 79.334  114.057 87.774  1.00 45.34  ? 485 VAL A CA  1 
ATOM 3511 C C   . VAL A 1 485 ? 78.013  114.631 88.270  1.00 45.34  ? 485 VAL A C   1 
ATOM 3512 O O   . VAL A 1 485 ? 77.973  115.352 89.273  1.00 45.34  ? 485 VAL A O   1 
ATOM 3513 C CB  . VAL A 1 485 ? 79.964  114.932 86.672  1.00 45.34  ? 485 VAL A CB  1 
ATOM 3514 C CG1 . VAL A 1 485 ? 80.027  116.390 87.098  1.00 45.34  ? 485 VAL A CG1 1 
ATOM 3515 C CG2 . VAL A 1 485 ? 81.355  114.434 86.335  1.00 45.34  ? 485 VAL A CG2 1 
ATOM 3516 N N   . THR A 1 486 ? 76.911  114.312 87.586  1.00 46.99  ? 486 THR A N   1 
ATOM 3517 C CA  . THR A 1 486 ? 75.596  114.776 88.008  1.00 46.99  ? 486 THR A CA  1 
ATOM 3518 C C   . THR A 1 486 ? 75.219  114.190 89.361  1.00 46.99  ? 486 THR A C   1 
ATOM 3519 O O   . THR A 1 486 ? 74.693  114.894 90.224  1.00 46.99  ? 486 THR A O   1 
ATOM 3520 C CB  . THR A 1 486 ? 74.554  114.415 86.948  1.00 46.99  ? 486 THR A CB  1 
ATOM 3521 O OG1 . THR A 1 486 ? 74.840  115.127 85.738  1.00 46.99  ? 486 THR A OG1 1 
ATOM 3522 C CG2 . THR A 1 486 ? 73.157  114.783 87.415  1.00 46.99  ? 486 THR A CG2 1 
ATOM 3523 N N   . SER A 1 487 ? 75.498  112.901 89.568  1.00 48.08  ? 487 SER A N   1 
ATOM 3524 C CA  . SER A 1 487 ? 75.226  112.268 90.854  1.00 48.08  ? 487 SER A CA  1 
ATOM 3525 C C   . SER A 1 487 ? 76.061  112.894 91.965  1.00 48.08  ? 487 SER A C   1 
ATOM 3526 O O   . SER A 1 487 ? 75.556  113.166 93.058  1.00 48.08  ? 487 SER A O   1 
ATOM 3527 C CB  . SER A 1 487 ? 75.494  110.766 90.757  1.00 48.08  ? 487 SER A CB  1 
ATOM 3528 O OG  . SER A 1 487 ? 75.344  110.135 92.014  1.00 48.08  ? 487 SER A OG  1 
ATOM 3529 N N   . PHE A 1 488 ? 77.343  113.148 91.689  1.00 49.88  ? 488 PHE A N   1 
ATOM 3530 C CA  . PHE A 1 488 ? 78.232  113.734 92.692  1.00 49.88  ? 488 PHE A CA  1 
ATOM 3531 C C   . PHE A 1 488 ? 77.807  115.159 93.054  1.00 49.88  ? 488 PHE A C   1 
ATOM 3532 O O   . PHE A 1 488 ? 77.695  115.508 94.242  1.00 49.88  ? 488 PHE A O   1 
ATOM 3533 C CB  . PHE A 1 488 ? 79.665  113.687 92.155  1.00 49.88  ? 488 PHE A CB  1 
ATOM 3534 C CG  . PHE A 1 488 ? 80.667  114.451 92.969  1.00 49.88  ? 488 PHE A CG  1 
ATOM 3535 C CD1 . PHE A 1 488 ? 81.041  114.008 94.225  1.00 49.88  ? 488 PHE A CD1 1 
ATOM 3536 C CD2 . PHE A 1 488 ? 81.271  115.585 92.456  1.00 49.88  ? 488 PHE A CD2 1 
ATOM 3537 C CE1 . PHE A 1 488 ? 81.979  114.700 94.967  1.00 49.88  ? 488 PHE A CE1 1 
ATOM 3538 C CE2 . PHE A 1 488 ? 82.208  116.280 93.191  1.00 49.88  ? 488 PHE A CE2 1 
ATOM 3539 C CZ  . PHE A 1 488 ? 82.565  115.834 94.447  1.00 49.88  ? 488 PHE A CZ  1 
ATOM 3540 N N   . LEU A 1 489 ? 77.523  115.983 92.043  1.00 51.58  ? 489 LEU A N   1 
ATOM 3541 C CA  . LEU A 1 489 ? 77.102  117.358 92.278  1.00 51.58  ? 489 LEU A CA  1 
ATOM 3542 C C   . LEU A 1 489 ? 75.714  117.423 92.898  1.00 51.58  ? 489 LEU A C   1 
ATOM 3543 O O   . LEU A 1 489 ? 75.444  118.307 93.713  1.00 51.58  ? 489 LEU A O   1 
ATOM 3544 C CB  . LEU A 1 489 ? 77.139  118.149 90.971  1.00 51.58  ? 489 LEU A CB  1 
ATOM 3545 C CG  . LEU A 1 489 ? 78.513  118.664 90.544  1.00 51.58  ? 489 LEU A CG  1 
ATOM 3546 C CD1 . LEU A 1 489 ? 78.438  119.320 89.176  1.00 51.58  ? 489 LEU A CD1 1 
ATOM 3547 C CD2 . LEU A 1 489 ? 79.073  119.625 91.578  1.00 51.58  ? 489 LEU A CD2 1 
ATOM 3548 N N   . THR A 1 490 ? 74.821  116.503 92.523  1.00 54.24  ? 490 THR A N   1 
ATOM 3549 C CA  . THR A 1 490 ? 73.509  116.428 93.151  1.00 54.24  ? 490 THR A CA  1 
ATOM 3550 C C   . THR A 1 490 ? 73.630  116.040 94.615  1.00 54.24  ? 490 THR A C   1 
ATOM 3551 O O   . THR A 1 490 ? 72.918  116.581 95.463  1.00 54.24  ? 490 THR A O   1 
ATOM 3552 C CB  . THR A 1 490 ? 72.627  115.428 92.404  1.00 54.24  ? 490 THR A CB  1 
ATOM 3553 O OG1 . THR A 1 490 ? 72.607  115.756 91.010  1.00 54.24  ? 490 THR A OG1 1 
ATOM 3554 C CG2 . THR A 1 490 ? 71.207  115.458 92.942  1.00 54.24  ? 490 THR A CG2 1 
ATOM 3555 N N   . ASN A 1 491 ? 74.533  115.106 94.927  1.00 56.09  ? 491 ASN A N   1 
ATOM 3556 C CA  . ASN A 1 491 ? 74.812  114.758 96.315  1.00 56.09  ? 491 ASN A CA  1 
ATOM 3557 C C   . ASN A 1 491 ? 75.223  115.991 97.107  1.00 56.09  ? 491 ASN A C   1 
ATOM 3558 O O   . ASN A 1 491 ? 74.621  116.305 98.141  1.00 56.09  ? 491 ASN A O   1 
ATOM 3559 C CB  . ASN A 1 491 ? 75.906  113.690 96.365  1.00 56.09  ? 491 ASN A CB  1 
ATOM 3560 C CG  . ASN A 1 491 ? 75.941  112.941 97.682  1.00 56.09  ? 491 ASN A CG  1 
ATOM 3561 O OD1 . ASN A 1 491 ? 75.961  113.539 98.756  1.00 56.09  ? 491 ASN A OD1 1 
ATOM 3562 N ND2 . ASN A 1 491 ? 75.962  111.618 97.602  1.00 56.09  ? 491 ASN A ND2 1 
ATOM 3563 N N   . ILE A 1 492 ? 76.206  116.736 96.592  1.00 60.98  ? 492 ILE A N   1 
ATOM 3564 C CA  . ILE A 1 492 ? 76.690  117.926 97.294  1.00 60.98  ? 492 ILE A CA  1 
ATOM 3565 C C   . ILE A 1 492 ? 75.579  118.967 97.435  1.00 60.98  ? 492 ILE A C   1 
ATOM 3566 O O   . ILE A 1 492 ? 75.333  119.495 98.530  1.00 60.98  ? 492 ILE A O   1 
ATOM 3567 C CB  . ILE A 1 492 ? 77.915  118.515 96.572  1.00 60.98  ? 492 ILE A CB  1 
ATOM 3568 C CG1 . ILE A 1 492 ? 79.142  117.637 96.791  1.00 60.98  ? 492 ILE A CG1 1 
ATOM 3569 C CG2 . ILE A 1 492 ? 78.195  119.932 97.045  1.00 60.98  ? 492 ILE A CG2 1 
ATOM 3570 C CD1 . ILE A 1 492 ? 80.314  118.049 95.948  1.00 60.98  ? 492 ILE A CD1 1 
ATOM 3571 N N   . CYS A 1 493 ? 74.878  119.254 96.335  1.00 67.12  ? 493 CYS A N   1 
ATOM 3572 C CA  . CYS A 1 493 ? 73.906  120.341 96.318  1.00 67.12  ? 493 CYS A CA  1 
ATOM 3573 C C   . CYS A 1 493 ? 72.696  120.025 97.186  1.00 67.12  ? 493 CYS A C   1 
ATOM 3574 O O   . CYS A 1 493 ? 72.253  120.870 97.966  1.00 67.12  ? 493 CYS A O   1 
ATOM 3575 C CB  . CYS A 1 493 ? 73.475  120.635 94.881  1.00 67.12  ? 493 CYS A CB  1 
ATOM 3576 S SG  . CYS A 1 493 ? 74.638  121.653 93.946  1.00 67.12  ? 493 CYS A SG  1 
ATOM 3577 N N   . ILE A 1 494 ? 72.144  118.815 97.066  1.00 66.19  ? 494 ILE A N   1 
ATOM 3578 C CA  . ILE A 1 494 ? 70.992  118.439 97.877  1.00 66.19  ? 494 ILE A CA  1 
ATOM 3579 C C   . ILE A 1 494 ? 71.381  118.298 99.343  1.00 66.19  ? 494 ILE A C   1 
ATOM 3580 O O   . ILE A 1 494 ? 70.590  118.645 100.228 1.00 66.19  ? 494 ILE A O   1 
ATOM 3581 C CB  . ILE A 1 494 ? 70.344  117.158 97.316  1.00 66.19  ? 494 ILE A CB  1 
ATOM 3582 C CG1 . ILE A 1 494 ? 69.858  117.401 95.886  1.00 66.19  ? 494 ILE A CG1 1 
ATOM 3583 C CG2 . ILE A 1 494 ? 69.177  116.704 98.180  1.00 66.19  ? 494 ILE A CG2 1 
ATOM 3584 C CD1 . ILE A 1 494 ? 68.701  118.370 95.788  1.00 66.19  ? 494 ILE A CD1 1 
ATOM 3585 N N   . SER A 1 495 ? 72.598  117.824 99.635  1.00 68.61  ? 495 SER A N   1 
ATOM 3586 C CA  . SER A 1 495 ? 73.053  117.759 101.019 1.00 68.61  ? 495 SER A CA  1 
ATOM 3587 C C   . SER A 1 495 ? 73.096  119.147 101.645 1.00 68.61  ? 495 SER A C   1 
ATOM 3588 O O   . SER A 1 495 ? 72.528  119.378 102.721 1.00 68.61  ? 495 SER A O   1 
ATOM 3589 C CB  . SER A 1 495 ? 74.431  117.099 101.082 1.00 68.61  ? 495 SER A CB  1 
ATOM 3590 O OG  . SER A 1 495 ? 74.387  115.773 100.589 1.00 68.61  ? 495 SER A OG  1 
ATOM 3591 N N   . TYR A 1 496 ? 73.739  120.097 100.961 1.00 77.52  ? 496 TYR A N   1 
ATOM 3592 C CA  . TYR A 1 496 ? 73.844  121.444 101.510 1.00 77.52  ? 496 TYR A CA  1 
ATOM 3593 C C   . TYR A 1 496 ? 72.492  122.149 101.519 1.00 77.52  ? 496 TYR A C   1 
ATOM 3594 O O   . TYR A 1 496 ? 72.209  122.944 102.423 1.00 77.52  ? 496 TYR A O   1 
ATOM 3595 C CB  . TYR A 1 496 ? 74.881  122.247 100.728 1.00 77.52  ? 496 TYR A CB  1 
ATOM 3596 C CG  . TYR A 1 496 ? 76.295  121.977 101.191 1.00 77.52  ? 496 TYR A CG  1 
ATOM 3597 C CD1 . TYR A 1 496 ? 76.705  122.327 102.470 1.00 77.52  ? 496 TYR A CD1 1 
ATOM 3598 C CD2 . TYR A 1 496 ? 77.213  121.351 100.357 1.00 77.52  ? 496 TYR A CD2 1 
ATOM 3599 C CE1 . TYR A 1 496 ? 77.992  122.076 102.902 1.00 77.52  ? 496 TYR A CE1 1 
ATOM 3600 C CE2 . TYR A 1 496 ? 78.503  121.094 100.781 1.00 77.52  ? 496 TYR A CE2 1 
ATOM 3601 C CZ  . TYR A 1 496 ? 78.887  121.459 102.054 1.00 77.52  ? 496 TYR A CZ  1 
ATOM 3602 O OH  . TYR A 1 496 ? 80.170  121.207 102.481 1.00 77.52  ? 496 TYR A OH  1 
ATOM 3603 N N   . LEU A 1 497 ? 71.631  121.847 100.545 1.00 80.71  ? 497 LEU A N   1 
ATOM 3604 C CA  . LEU A 1 497 ? 70.304  122.449 100.493 1.00 80.71  ? 497 LEU A CA  1 
ATOM 3605 C C   . LEU A 1 497 ? 69.446  121.983 101.662 1.00 80.71  ? 497 LEU A C   1 
ATOM 3606 O O   . LEU A 1 497 ? 68.795  122.792 102.329 1.00 80.71  ? 497 LEU A O   1 
ATOM 3607 C CB  . LEU A 1 497 ? 69.636  122.113 99.158  1.00 80.71  ? 497 LEU A CB  1 
ATOM 3608 C CG  . LEU A 1 497 ? 68.198  122.591 98.956  1.00 80.71  ? 497 LEU A CG  1 
ATOM 3609 C CD1 . LEU A 1 497 ? 68.126  124.109 98.984  1.00 80.71  ? 497 LEU A CD1 1 
ATOM 3610 C CD2 . LEU A 1 497 ? 67.634  122.049 97.653  1.00 80.71  ? 497 LEU A CD2 1 
ATOM 3611 N N   . ALA A 1 498 ? 69.434  120.673 101.923 1.00 83.12  ? 498 ALA A N   1 
ATOM 3612 C CA  . ALA A 1 498 ? 68.690  120.142 103.061 1.00 83.12  ? 498 ALA A CA  1 
ATOM 3613 C C   . ALA A 1 498 ? 69.264  120.654 104.374 1.00 83.12  ? 498 ALA A C   1 
ATOM 3614 O O   . ALA A 1 498 ? 68.519  120.964 105.313 1.00 83.12  ? 498 ALA A O   1 
ATOM 3615 C CB  . ALA A 1 498 ? 68.697  118.614 103.025 1.00 83.12  ? 498 ALA A CB  1 
ATOM 3616 N N   . LYS A 1 499 ? 70.595  120.756 104.455 1.00 86.85  ? 499 LYS A N   1 
ATOM 3617 C CA  . LYS A 1 499 ? 71.229  121.301 105.650 1.00 86.85  ? 499 LYS A CA  1 
ATOM 3618 C C   . LYS A 1 499 ? 70.785  122.737 105.896 1.00 86.85  ? 499 LYS A C   1 
ATOM 3619 O O   . LYS A 1 499 ? 70.457  123.112 107.027 1.00 86.85  ? 499 LYS A O   1 
ATOM 3620 C CB  . LYS A 1 499 ? 72.750  121.220 105.512 1.00 86.85  ? 499 LYS A CB  1 
ATOM 3621 C CG  . LYS A 1 499 ? 73.512  121.544 106.784 1.00 86.85  ? 499 LYS A CG  1 
ATOM 3622 C CD  . LYS A 1 499 ? 75.012  121.461 106.554 1.00 86.85  ? 499 LYS A CD  1 
ATOM 3623 C CE  . LYS A 1 499 ? 75.452  120.029 106.301 1.00 86.85  ? 499 LYS A CE  1 
ATOM 3624 N NZ  . LYS A 1 499 ? 75.267  119.171 107.503 1.00 86.85  ? 499 LYS A NZ  1 
ATOM 3625 N N   . TYR A 1 500 ? 70.737  123.547 104.835 1.00 97.60  ? 500 TYR A N   1 
ATOM 3626 C CA  . TYR A 1 500 ? 70.297  124.932 104.967 1.00 97.60  ? 500 TYR A CA  1 
ATOM 3627 C C   . TYR A 1 500 ? 68.819  125.013 105.335 1.00 97.60  ? 500 TYR A C   1 
ATOM 3628 O O   . TYR A 1 500 ? 68.416  125.865 106.135 1.00 97.60  ? 500 TYR A O   1 
ATOM 3629 C CB  . TYR A 1 500 ? 70.581  125.693 103.670 1.00 97.60  ? 500 TYR A CB  1 
ATOM 3630 C CG  . TYR A 1 500 ? 69.795  126.976 103.510 1.00 97.60  ? 500 TYR A CG  1 
ATOM 3631 C CD1 . TYR A 1 500 ? 70.187  128.138 104.163 1.00 97.60  ? 500 TYR A CD1 1 
ATOM 3632 C CD2 . TYR A 1 500 ? 68.676  127.033 102.686 1.00 97.60  ? 500 TYR A CD2 1 
ATOM 3633 C CE1 . TYR A 1 500 ? 69.475  129.314 104.017 1.00 97.60  ? 500 TYR A CE1 1 
ATOM 3634 C CE2 . TYR A 1 500 ? 67.959  128.204 102.534 1.00 97.60  ? 500 TYR A CE2 1 
ATOM 3635 C CZ  . TYR A 1 500 ? 68.364  129.341 103.201 1.00 97.60  ? 500 TYR A CZ  1 
ATOM 3636 O OH  . TYR A 1 500 ? 67.654  130.510 103.050 1.00 97.60  ? 500 TYR A OH  1 
ATOM 3637 N N   . LEU A 1 501 ? 67.994  124.139 104.749 1.00 96.04  ? 501 LEU A N   1 
ATOM 3638 C CA  . LEU A 1 501 ? 66.562  124.151 105.040 1.00 96.04  ? 501 LEU A CA  1 
ATOM 3639 C C   . LEU A 1 501 ? 66.287  123.812 106.499 1.00 96.04  ? 501 LEU A C   1 
ATOM 3640 O O   . LEU A 1 501 ? 65.460  124.457 107.153 1.00 96.04  ? 501 LEU A O   1 
ATOM 3641 C CB  . LEU A 1 501 ? 65.820  123.179 104.120 1.00 96.04  ? 501 LEU A CB  1 
ATOM 3642 C CG  . LEU A 1 501 ? 65.706  123.518 102.632 1.00 96.04  ? 501 LEU A CG  1 
ATOM 3643 C CD1 . LEU A 1 501 ? 65.112  122.347 101.864 1.00 96.04  ? 501 LEU A CD1 1 
ATOM 3644 C CD2 . LEU A 1 501 ? 64.887  124.778 102.412 1.00 96.04  ? 501 LEU A CD2 1 
ATOM 3645 N N   . PHE A 1 502 ? 66.972  122.797 107.031 1.00 99.58  ? 502 PHE A N   1 
ATOM 3646 C CA  . PHE A 1 502 ? 66.740  122.429 108.425 1.00 99.58  ? 502 PHE A CA  1 
ATOM 3647 C C   . PHE A 1 502 ? 67.409  123.407 109.387 1.00 99.58  ? 502 PHE A C   1 
ATOM 3648 O O   . PHE A 1 502 ? 66.906  123.635 110.494 1.00 99.58  ? 502 PHE A O   1 
ATOM 3649 C CB  . PHE A 1 502 ? 67.203  120.996 108.691 1.00 99.58  ? 502 PHE A CB  1 
ATOM 3650 C CG  . PHE A 1 502 ? 66.336  119.950 108.043 1.00 99.58  ? 502 PHE A CG  1 
ATOM 3651 C CD1 . PHE A 1 502 ? 65.009  119.809 108.419 1.00 99.58  ? 502 PHE A CD1 1 
ATOM 3652 C CD2 . PHE A 1 502 ? 66.847  119.094 107.084 1.00 99.58  ? 502 PHE A CD2 1 
ATOM 3653 C CE1 . PHE A 1 502 ? 64.205  118.849 107.834 1.00 99.58  ? 502 PHE A CE1 1 
ATOM 3654 C CE2 . PHE A 1 502 ? 66.049  118.133 106.495 1.00 99.58  ? 502 PHE A CE2 1 
ATOM 3655 C CZ  . PHE A 1 502 ? 64.727  118.010 106.872 1.00 99.58  ? 502 PHE A CZ  1 
ATOM 3656 N N   . GLU A 1 503 ? 68.544  123.994 108.994 1.00 102.23 ? 503 GLU A N   1 
ATOM 3657 C CA  . GLU A 1 503 ? 69.228  124.931 109.880 1.00 102.23 ? 503 GLU A CA  1 
ATOM 3658 C C   . GLU A 1 503 ? 68.477  126.253 109.982 1.00 102.23 ? 503 GLU A C   1 
ATOM 3659 O O   . GLU A 1 503 ? 68.289  126.782 111.084 1.00 102.23 ? 503 GLU A O   1 
ATOM 3660 C CB  . GLU A 1 503 ? 70.657  125.161 109.389 1.00 102.23 ? 503 GLU A CB  1 
ATOM 3661 C CG  . GLU A 1 503 ? 71.474  126.101 110.260 1.00 102.23 ? 503 GLU A CG  1 
ATOM 3662 C CD  . GLU A 1 503 ? 71.813  125.498 111.609 1.00 102.23 ? 503 GLU A CD  1 
ATOM 3663 O OE1 . GLU A 1 503 ? 71.909  124.255 111.700 1.00 102.23 ? 503 GLU A OE1 1 
ATOM 3664 O OE2 . GLU A 1 503 ? 71.982  126.266 112.580 1.00 102.23 ? 503 GLU A OE2 1 
ATOM 3665 N N   . SER A 1 504 ? 68.041  126.803 108.846 1.00 102.91 ? 504 SER A N   1 
ATOM 3666 C CA  . SER A 1 504 ? 67.336  128.081 108.867 1.00 102.91 ? 504 SER A CA  1 
ATOM 3667 C C   . SER A 1 504 ? 65.925  127.926 109.419 1.00 102.91 ? 504 SER A C   1 
ATOM 3668 O O   . SER A 1 504 ? 65.358  128.876 109.972 1.00 102.91 ? 504 SER A O   1 
ATOM 3669 C CB  . SER A 1 504 ? 67.300  128.682 107.462 1.00 102.91 ? 504 SER A CB  1 
ATOM 3670 O OG  . SER A 1 504 ? 66.572  129.898 107.446 1.00 102.91 ? 504 SER A OG  1 
ATOM 3671 N N   . GLY A 1 505 ? 65.342  126.739 109.281 1.00 103.72 ? 505 GLY A N   1 
ATOM 3672 C CA  . GLY A 1 505 ? 63.996  126.493 109.751 1.00 103.72 ? 505 GLY A CA  1 
ATOM 3673 C C   . GLY A 1 505 ? 62.920  126.535 108.692 1.00 103.72 ? 505 GLY A C   1 
ATOM 3674 O O   . GLY A 1 505 ? 61.735  126.597 109.044 1.00 103.72 ? 505 GLY A O   1 
ATOM 3675 N N   . THR A 1 506 ? 63.290  126.524 107.408 1.00 103.74 ? 506 THR A N   1 
ATOM 3676 C CA  . THR A 1 506 ? 62.291  126.524 106.343 1.00 103.74 ? 506 THR A CA  1 
ATOM 3677 C C   . THR A 1 506 ? 61.456  125.248 106.374 1.00 103.74 ? 506 THR A C   1 
ATOM 3678 O O   . THR A 1 506 ? 60.223  125.295 106.292 1.00 103.74 ? 506 THR A O   1 
ATOM 3679 C CB  . THR A 1 506 ? 62.976  126.690 104.985 1.00 103.74 ? 506 THR A CB  1 
ATOM 3680 O OG1 . THR A 1 506 ? 63.633  127.962 104.932 1.00 103.74 ? 506 THR A OG1 1 
ATOM 3681 C CG2 . THR A 1 506 ? 61.958  126.608 103.856 1.00 103.74 ? 506 THR A CG2 1 
ATOM 3682 N N   . LEU A 1 507 ? 62.112  124.097 106.506 1.00 106.63 ? 507 LEU A N   1 
ATOM 3683 C CA  . LEU A 1 507 ? 61.345  122.869 106.646 1.00 106.63 ? 507 LEU A CA  1 
ATOM 3684 C C   . LEU A 1 507 ? 61.177  122.514 108.117 1.00 106.63 ? 507 LEU A C   1 
ATOM 3685 O O   . LEU A 1 507 ? 62.092  122.745 108.917 1.00 106.63 ? 507 LEU A O   1 
ATOM 3686 C CB  . LEU A 1 507 ? 62.028  121.710 105.919 1.00 106.63 ? 507 LEU A CB  1 
ATOM 3687 C CG  . LEU A 1 507 ? 61.965  121.727 104.391 1.00 106.63 ? 507 LEU A CG  1 
ATOM 3688 C CD1 . LEU A 1 507 ? 62.521  120.432 103.820 1.00 106.63 ? 507 LEU A CD1 1 
ATOM 3689 C CD2 . LEU A 1 507 ? 60.542  121.963 103.911 1.00 106.63 ? 507 LEU A CD2 1 
ATOM 3690 N N   . PRO A 1 508 ? 60.021  121.976 108.499 1.00 107.28 ? 508 PRO A N   1 
ATOM 3691 C CA  . PRO A 1 508 ? 59.796  121.601 109.901 1.00 107.28 ? 508 PRO A CA  1 
ATOM 3692 C C   . PRO A 1 508 ? 60.728  120.482 110.328 1.00 107.28 ? 508 PRO A C   1 
ATOM 3693 O O   . PRO A 1 508 ? 61.070  119.604 109.521 1.00 107.28 ? 508 PRO A O   1 
ATOM 3694 C CB  . PRO A 1 508 ? 58.330  121.140 109.915 1.00 107.28 ? 508 PRO A CB  1 
ATOM 3695 C CG  . PRO A 1 508 ? 57.719  121.758 108.698 1.00 107.28 ? 508 PRO A CG  1 
ATOM 3696 C CD  . PRO A 1 508 ? 58.813  121.790 107.678 1.00 107.28 ? 508 PRO A CD  1 
ATOM 3697 N N   . PRO A 1 509 ? 61.175  120.489 111.588 1.00 107.43 ? 509 PRO A N   1 
ATOM 3698 C CA  . PRO A 1 509 ? 62.022  119.382 112.070 1.00 107.43 ? 509 PRO A CA  1 
ATOM 3699 C C   . PRO A 1 509 ? 61.311  118.040 112.097 1.00 107.43 ? 509 PRO A C   1 
ATOM 3700 O O   . PRO A 1 509 ? 61.974  116.995 112.115 1.00 107.43 ? 509 PRO A O   1 
ATOM 3701 C CB  . PRO A 1 509 ? 62.425  119.840 113.480 1.00 107.43 ? 509 PRO A CB  1 
ATOM 3702 C CG  . PRO A 1 509 ? 62.216  121.322 113.486 1.00 107.43 ? 509 PRO A CG  1 
ATOM 3703 C CD  . PRO A 1 509 ? 61.049  121.567 112.583 1.00 107.43 ? 509 PRO A CD  1 
ATOM 3704 N N   . LYS A 1 510 ? 59.974  118.042 112.121 1.00 106.33 ? 510 LYS A N   1 
ATOM 3705 C CA  . LYS A 1 510 ? 59.221  116.791 112.137 1.00 106.33 ? 510 LYS A CA  1 
ATOM 3706 C C   . LYS A 1 510 ? 59.437  115.991 110.860 1.00 106.33 ? 510 LYS A C   1 
ATOM 3707 O O   . LYS A 1 510 ? 59.540  114.759 110.899 1.00 106.33 ? 510 LYS A O   1 
ATOM 3708 C CB  . LYS A 1 510 ? 57.733  117.077 112.341 1.00 106.33 ? 510 LYS A CB  1 
ATOM 3709 C CG  . LYS A 1 510 ? 57.384  117.613 113.719 1.00 106.33 ? 510 LYS A CG  1 
ATOM 3710 C CD  . LYS A 1 510 ? 55.891  117.862 113.848 1.00 106.33 ? 510 LYS A CD  1 
ATOM 3711 C CE  . LYS A 1 510 ? 55.532  118.363 115.236 1.00 106.33 ? 510 LYS A CE  1 
ATOM 3712 N NZ  . LYS A 1 510 ? 54.071  118.615 115.373 1.00 106.33 ? 510 LYS A NZ  1 
ATOM 3713 N N   . LEU A 1 511 ? 59.511  116.672 109.715 1.00 102.29 ? 511 LEU A N   1 
ATOM 3714 C CA  . LEU A 1 511 ? 59.721  116.003 108.431 1.00 102.29 ? 511 LEU A CA  1 
ATOM 3715 C C   . LEU A 1 511 ? 61.214  115.713 108.260 1.00 102.29 ? 511 LEU A C   1 
ATOM 3716 O O   . LEU A 1 511 ? 61.928  116.323 107.460 1.00 102.29 ? 511 LEU A O   1 
ATOM 3717 C CB  . LEU A 1 511 ? 59.168  116.849 107.291 1.00 102.29 ? 511 LEU A CB  1 
ATOM 3718 C CG  . LEU A 1 511 ? 59.121  116.209 105.900 1.00 102.29 ? 511 LEU A CG  1 
ATOM 3719 C CD1 . LEU A 1 511 ? 58.258  114.958 105.914 1.00 102.29 ? 511 LEU A CD1 1 
ATOM 3720 C CD2 . LEU A 1 511 ? 58.616  117.203 104.866 1.00 102.29 ? 511 LEU A CD2 1 
ATOM 3721 N N   . ASP A 1 512 ? 61.691  114.760 109.062 1.00 98.24  ? 512 ASP A N   1 
ATOM 3722 C CA  . ASP A 1 512 ? 63.064  114.267 108.988 1.00 98.24  ? 512 ASP A CA  1 
ATOM 3723 C C   . ASP A 1 512 ? 62.997  112.738 108.941 1.00 98.24  ? 512 ASP A C   1 
ATOM 3724 O O   . ASP A 1 512 ? 63.123  112.055 109.959 1.00 98.24  ? 512 ASP A O   1 
ATOM 3725 C CB  . ASP A 1 512 ? 63.894  114.770 110.172 1.00 98.24  ? 512 ASP A CB  1 
ATOM 3726 C CG  . ASP A 1 512 ? 65.375  114.494 110.010 1.00 98.24  ? 512 ASP A CG  1 
ATOM 3727 O OD1 . ASP A 1 512 ? 65.792  114.082 108.908 1.00 98.24  ? 512 ASP A OD1 1 
ATOM 3728 O OD2 . ASP A 1 512 ? 66.125  114.691 110.989 1.00 98.24  ? 512 ASP A OD2 1 
ATOM 3729 N N   . VAL A 1 513 ? 62.800  112.204 107.735 1.00 93.47  ? 513 VAL A N   1 
ATOM 3730 C CA  . VAL A 1 513 ? 62.587  110.767 107.582 1.00 93.47  ? 513 VAL A CA  1 
ATOM 3731 C C   . VAL A 1 513 ? 63.912  110.015 107.627 1.00 93.47  ? 513 VAL A C   1 
ATOM 3732 O O   . VAL A 1 513 ? 63.959  108.833 107.990 1.00 93.47  ? 513 VAL A O   1 
ATOM 3733 C CB  . VAL A 1 513 ? 61.803  110.480 106.287 1.00 93.47  ? 513 VAL A CB  1 
ATOM 3734 C CG1 . VAL A 1 513 ? 60.410  111.076 106.377 1.00 93.47  ? 513 VAL A CG1 1 
ATOM 3735 C CG2 . VAL A 1 513 ? 62.527  111.056 105.083 1.00 93.47  ? 513 VAL A CG2 1 
ATOM 3736 N N   . PHE A 1 514 ? 65.005  110.680 107.255 1.00 88.41  ? 514 PHE A N   1 
ATOM 3737 C CA  . PHE A 1 514 ? 66.314  110.045 107.174 1.00 88.41  ? 514 PHE A CA  1 
ATOM 3738 C C   . PHE A 1 514 ? 67.211  110.353 108.365 1.00 88.41  ? 514 PHE A C   1 
ATOM 3739 O O   . PHE A 1 514 ? 68.283  109.747 108.478 1.00 88.41  ? 514 PHE A O   1 
ATOM 3740 C CB  . PHE A 1 514 ? 67.022  110.466 105.878 1.00 88.41  ? 514 PHE A CB  1 
ATOM 3741 C CG  . PHE A 1 514 ? 66.390  109.915 104.624 1.00 88.41  ? 514 PHE A CG  1 
ATOM 3742 C CD1 . PHE A 1 514 ? 66.870  110.283 103.381 1.00 88.41  ? 514 PHE A CD1 1 
ATOM 3743 C CD2 . PHE A 1 514 ? 65.366  108.983 104.686 1.00 88.41  ? 514 PHE A CD2 1 
ATOM 3744 C CE1 . PHE A 1 514 ? 66.303  109.781 102.228 1.00 88.41  ? 514 PHE A CE1 1 
ATOM 3745 C CE2 . PHE A 1 514 ? 64.799  108.474 103.535 1.00 88.41  ? 514 PHE A CE2 1 
ATOM 3746 C CZ  . PHE A 1 514 ? 65.272  108.870 102.305 1.00 88.41  ? 514 PHE A CZ  1 
ATOM 3747 N N   . ASP A 1 515 ? 66.804  111.278 109.239 1.00 94.47  ? 515 ASP A N   1 
ATOM 3748 C CA  . ASP A 1 515 ? 67.539  111.673 110.443 1.00 94.47  ? 515 ASP A CA  1 
ATOM 3749 C C   . ASP A 1 515 ? 68.947  112.176 110.119 1.00 94.47  ? 515 ASP A C   1 
ATOM 3750 O O   . ASP A 1 515 ? 69.863  112.062 110.940 1.00 94.47  ? 515 ASP A O   1 
ATOM 3751 C CB  . ASP A 1 515 ? 67.588  110.524 111.463 1.00 94.47  ? 515 ASP A CB  1 
ATOM 3752 C CG  . ASP A 1 515 ? 67.891  110.999 112.874 1.00 94.47  ? 515 ASP A CG  1 
ATOM 3753 O OD1 . ASP A 1 515 ? 67.198  111.921 113.353 1.00 94.47  ? 515 ASP A OD1 1 
ATOM 3754 O OD2 . ASP A 1 515 ? 68.819  110.448 113.502 1.00 94.47  ? 515 ASP A OD2 1 
ATOM 3755 N N   . ALA A 1 516 ? 69.136  112.734 108.921 1.00 89.15  ? 516 ALA A N   1 
ATOM 3756 C CA  . ALA A 1 516 ? 70.458  113.193 108.515 1.00 89.15  ? 516 ALA A CA  1 
ATOM 3757 C C   . ALA A 1 516 ? 70.850  114.493 109.205 1.00 89.15  ? 516 ALA A C   1 
ATOM 3758 O O   . ALA A 1 516 ? 72.000  114.644 109.631 1.00 89.15  ? 516 ALA A O   1 
ATOM 3759 C CB  . ALA A 1 516 ? 70.505  113.360 106.998 1.00 89.15  ? 516 ALA A CB  1 
ATOM 3760 N N   . VAL A 1 517 ? 69.923  115.438 109.321 1.00 98.23  ? 517 VAL A N   1 
ATOM 3761 C CA  . VAL A 1 517 ? 70.217  116.722 109.946 1.00 98.23  ? 517 VAL A CA  1 
ATOM 3762 C C   . VAL A 1 517 ? 69.297  116.952 111.139 1.00 98.23  ? 517 VAL A C   1 
ATOM 3763 O O   . VAL A 1 517 ? 69.758  117.238 112.245 1.00 98.23  ? 517 VAL A O   1 
ATOM 3764 C CB  . VAL A 1 517 ? 70.093  117.877 108.935 1.00 98.23  ? 517 VAL A CB  1 
ATOM 3765 C CG1 . VAL A 1 517 ? 70.342  119.209 109.623 1.00 98.23  ? 517 VAL A CG1 1 
ATOM 3766 C CG2 . VAL A 1 517 ? 71.060  117.681 107.777 1.00 98.23  ? 517 VAL A CG2 1 
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