data_9BBR
# 
_entry.id   9BBR 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BBR         pdb_00009bbr 10.2210/pdb9bbr/pdb 
WWPDB D_1000282097 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-04-16 ? 
2 'Structure model' 1 1 2025-05-14 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Derived calculations' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' pdbx_struct_assembly      
2 2 'Structure model' pdbx_struct_assembly_gen  
3 2 'Structure model' pdbx_struct_assembly_prop 
4 2 'Structure model' pdbx_struct_oper_list     
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_pdbx_struct_assembly.details'             
2 2 'Structure model' '_pdbx_struct_assembly.method_details'      
3 2 'Structure model' '_pdbx_struct_assembly.oligomeric_count'    
4 2 'Structure model' '_pdbx_struct_assembly.oligomeric_details'  
5 2 'Structure model' '_pdbx_struct_assembly_gen.oper_expression' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BBR 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-07 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 4 
_pdbx_contact_author.email              olsens@uthscsa.edu 
_pdbx_contact_author.name_first         Shaun 
_pdbx_contact_author.name_last          Olsen 
_pdbx_contact_author.name_mi            K 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-1265-7101 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Afsar, M.'   1 0000-0002-3062-9219 
'Bury, P.'    2 0000-0003-3445-2649 
'Olsen, S.K.' 3 0000-0002-1265-7101 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'SARS-CoV-2 Mpro in complex with compound 6b inhibitor' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Afsar, M.'   1 0000-0002-3062-9219 
primary 'Bury, P.'    2 0000-0003-3445-2649 
primary 'Olsen, S.K.' 3 0000-0002-1265-7101 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '3C-like proteinase nsp5' 33825.547 1   3.4.22.69 ? ? ? 
2 non-polymer syn 
;4'-fluoro-N-[(2S)-1-({(2R)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)-4-methyl-1-oxopentan-2-yl][1,1'-biphenyl]-4-carboxamide
;
466.548   1   ?         ? ? ? 
3 water       nat water 18.015    162 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 
;4'-fluoro-N-[(2S)-1-({(2R)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)-4-methyl-1-oxopentan-2-yl][1,1'-biphenyl]-4-carboxamide
;
A1ALL 
3 water HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   GLY n 
1 3   PHE n 
1 4   ARG n 
1 5   LYS n 
1 6   MET n 
1 7   ALA n 
1 8   PHE n 
1 9   PRO n 
1 10  SER n 
1 11  GLY n 
1 12  LYS n 
1 13  VAL n 
1 14  GLU n 
1 15  GLY n 
1 16  CYS n 
1 17  MET n 
1 18  VAL n 
1 19  GLN n 
1 20  VAL n 
1 21  THR n 
1 22  CYS n 
1 23  GLY n 
1 24  THR n 
1 25  THR n 
1 26  THR n 
1 27  LEU n 
1 28  ASN n 
1 29  GLY n 
1 30  LEU n 
1 31  TRP n 
1 32  LEU n 
1 33  ASP n 
1 34  ASP n 
1 35  VAL n 
1 36  VAL n 
1 37  TYR n 
1 38  CYS n 
1 39  PRO n 
1 40  ARG n 
1 41  HIS n 
1 42  VAL n 
1 43  ILE n 
1 44  CYS n 
1 45  THR n 
1 46  SER n 
1 47  GLU n 
1 48  ASP n 
1 49  MET n 
1 50  LEU n 
1 51  ASN n 
1 52  PRO n 
1 53  ASN n 
1 54  TYR n 
1 55  GLU n 
1 56  ASP n 
1 57  LEU n 
1 58  LEU n 
1 59  ILE n 
1 60  ARG n 
1 61  LYS n 
1 62  SER n 
1 63  ASN n 
1 64  HIS n 
1 65  ASN n 
1 66  PHE n 
1 67  LEU n 
1 68  VAL n 
1 69  GLN n 
1 70  ALA n 
1 71  GLY n 
1 72  ASN n 
1 73  VAL n 
1 74  GLN n 
1 75  LEU n 
1 76  ARG n 
1 77  VAL n 
1 78  ILE n 
1 79  GLY n 
1 80  HIS n 
1 81  SER n 
1 82  MET n 
1 83  GLN n 
1 84  ASN n 
1 85  CYS n 
1 86  VAL n 
1 87  LEU n 
1 88  LYS n 
1 89  LEU n 
1 90  LYS n 
1 91  VAL n 
1 92  ASP n 
1 93  THR n 
1 94  ALA n 
1 95  ASN n 
1 96  PRO n 
1 97  LYS n 
1 98  THR n 
1 99  PRO n 
1 100 LYS n 
1 101 TYR n 
1 102 LYS n 
1 103 PHE n 
1 104 VAL n 
1 105 ARG n 
1 106 ILE n 
1 107 GLN n 
1 108 PRO n 
1 109 GLY n 
1 110 GLN n 
1 111 THR n 
1 112 PHE n 
1 113 SER n 
1 114 VAL n 
1 115 LEU n 
1 116 ALA n 
1 117 CYS n 
1 118 TYR n 
1 119 ASN n 
1 120 GLY n 
1 121 SER n 
1 122 PRO n 
1 123 SER n 
1 124 GLY n 
1 125 VAL n 
1 126 TYR n 
1 127 GLN n 
1 128 CYS n 
1 129 ALA n 
1 130 MET n 
1 131 ARG n 
1 132 PRO n 
1 133 ASN n 
1 134 PHE n 
1 135 THR n 
1 136 ILE n 
1 137 LYS n 
1 138 GLY n 
1 139 SER n 
1 140 PHE n 
1 141 LEU n 
1 142 ASN n 
1 143 GLY n 
1 144 SER n 
1 145 CYS n 
1 146 GLY n 
1 147 SER n 
1 148 VAL n 
1 149 GLY n 
1 150 PHE n 
1 151 ASN n 
1 152 ILE n 
1 153 ASP n 
1 154 TYR n 
1 155 ASP n 
1 156 CYS n 
1 157 VAL n 
1 158 SER n 
1 159 PHE n 
1 160 CYS n 
1 161 TYR n 
1 162 MET n 
1 163 HIS n 
1 164 HIS n 
1 165 MET n 
1 166 GLU n 
1 167 LEU n 
1 168 PRO n 
1 169 THR n 
1 170 GLY n 
1 171 VAL n 
1 172 HIS n 
1 173 ALA n 
1 174 GLY n 
1 175 THR n 
1 176 ASP n 
1 177 LEU n 
1 178 GLU n 
1 179 GLY n 
1 180 ASN n 
1 181 PHE n 
1 182 TYR n 
1 183 GLY n 
1 184 PRO n 
1 185 PHE n 
1 186 VAL n 
1 187 ASP n 
1 188 ARG n 
1 189 GLN n 
1 190 THR n 
1 191 ALA n 
1 192 GLN n 
1 193 ALA n 
1 194 ALA n 
1 195 GLY n 
1 196 THR n 
1 197 ASP n 
1 198 THR n 
1 199 THR n 
1 200 ILE n 
1 201 THR n 
1 202 VAL n 
1 203 ASN n 
1 204 VAL n 
1 205 LEU n 
1 206 ALA n 
1 207 TRP n 
1 208 LEU n 
1 209 TYR n 
1 210 ALA n 
1 211 ALA n 
1 212 VAL n 
1 213 ILE n 
1 214 ASN n 
1 215 GLY n 
1 216 ASP n 
1 217 ARG n 
1 218 TRP n 
1 219 PHE n 
1 220 LEU n 
1 221 ASN n 
1 222 ARG n 
1 223 PHE n 
1 224 THR n 
1 225 THR n 
1 226 THR n 
1 227 LEU n 
1 228 ASN n 
1 229 ASP n 
1 230 PHE n 
1 231 ASN n 
1 232 LEU n 
1 233 VAL n 
1 234 ALA n 
1 235 MET n 
1 236 LYS n 
1 237 TYR n 
1 238 ASN n 
1 239 TYR n 
1 240 GLU n 
1 241 PRO n 
1 242 LEU n 
1 243 THR n 
1 244 GLN n 
1 245 ASP n 
1 246 HIS n 
1 247 VAL n 
1 248 ASP n 
1 249 ILE n 
1 250 LEU n 
1 251 GLY n 
1 252 PRO n 
1 253 LEU n 
1 254 SER n 
1 255 ALA n 
1 256 GLN n 
1 257 THR n 
1 258 GLY n 
1 259 ILE n 
1 260 ALA n 
1 261 VAL n 
1 262 LEU n 
1 263 ASP n 
1 264 MET n 
1 265 CYS n 
1 266 ALA n 
1 267 SER n 
1 268 LEU n 
1 269 LYS n 
1 270 GLU n 
1 271 LEU n 
1 272 LEU n 
1 273 GLN n 
1 274 ASN n 
1 275 GLY n 
1 276 MET n 
1 277 ASN n 
1 278 GLY n 
1 279 ARG n 
1 280 THR n 
1 281 ILE n 
1 282 LEU n 
1 283 GLY n 
1 284 SER n 
1 285 ALA n 
1 286 LEU n 
1 287 LEU n 
1 288 GLU n 
1 289 ASP n 
1 290 GLU n 
1 291 PHE n 
1 292 THR n 
1 293 PRO n 
1 294 PHE n 
1 295 ASP n 
1 296 VAL n 
1 297 VAL n 
1 298 ARG n 
1 299 GLN n 
1 300 CYS n 
1 301 SER n 
1 302 GLY n 
1 303 VAL n 
1 304 THR n 
1 305 PHE n 
1 306 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   306 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'rep, 1a-1b' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      
;Escherichia coli 'BL21-Gold(DE3)pLysS AG'
;
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     866768 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1ALL non-polymer         . 
;4'-fluoro-N-[(2S)-1-({(2R)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)-4-methyl-1-oxopentan-2-yl][1,1'-biphenyl]-4-carboxamide
;
? 'C26 H31 F N4 O3' 466.548 
ALA   'L-peptide linking' y ALANINE ? 'C3 H7 N O2'      89.093  
ARG   'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'  175.209 
ASN   'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'     132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'      133.103 
CYS   'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'    121.158 
GLN   'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'    146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'      147.129 
GLY   'peptide linking'   y GLYCINE ? 'C2 H5 N O2'      75.067  
HIS   'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'  156.162 
HOH   non-polymer         . WATER ? 'H2 O'            18.015  
ILE   'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'     131.173 
LEU   'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'     131.173 
LYS   'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'  147.195 
MET   'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'   149.211 
PHE   'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'     165.189 
PRO   'L-peptide linking' y PROLINE ? 'C5 H9 N O2'      115.130 
SER   'L-peptide linking' y SERINE ? 'C3 H7 N O3'      105.093 
THR   'L-peptide linking' y THREONINE ? 'C4 H9 N O3'      119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'   204.225 
TYR   'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'     181.189 
VAL   'L-peptide linking' y VALINE ? 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1   1   SER SER A . n 
A 1 2   GLY 2   2   2   GLY GLY A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ARG 4   4   4   ARG ARG A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   MET 6   6   6   MET MET A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  CYS 16  16  16  CYS CYS A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  THR 21  21  21  THR THR A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  ASN 28  28  28  ASN ASN A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  TRP 31  31  31  TRP TRP A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  ASP 34  34  34  ASP ASP A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  CYS 38  38  38  CYS CYS A . n 
A 1 39  PRO 39  39  39  PRO PRO A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  CYS 44  44  44  CYS CYS A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  GLU 47  47  47  GLU ALA A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  MET 49  49  49  MET MET A . n 
A 1 50  LEU 50  50  50  LEU LEU A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  ASP 56  56  56  ASP ASP A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  HIS 64  64  64  HIS HIS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  MET 82  82  82  MET MET A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  CYS 85  85  85  CYS CYS A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  ASP 92  92  92  ASP ASP A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  PRO 99  99  99  PRO PRO A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ARG 105 105 105 ARG ARG A . n 
A 1 106 ILE 106 106 106 ILE ILE A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 PHE 134 134 134 PHE PHE A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 CYS 145 145 145 CYS CYS A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 ASP 153 153 153 ASP ASP A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 CYS 156 156 156 CYS CYS A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 CYS 160 160 160 CYS CYS A . n 
A 1 161 TYR 161 161 161 TYR TYR A . n 
A 1 162 MET 162 162 162 MET MET A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 MET 165 165 165 MET MET A . n 
A 1 166 GLU 166 166 166 GLU GLU A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 HIS 172 172 172 HIS HIS A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 GLN 189 189 189 GLN GLN A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 GLN 192 192 192 GLN GLN A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 ILE 200 200 200 ILE ILE A . n 
A 1 201 THR 201 201 201 THR THR A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 TRP 207 207 207 TRP TRP A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ARG 217 217 217 ARG ARG A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ASN 221 221 221 ASN ASN A . n 
A 1 222 ARG 222 222 222 ARG ARG A . n 
A 1 223 PHE 223 223 223 PHE PHE A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 MET 235 235 235 MET MET A . n 
A 1 236 LYS 236 236 236 LYS LYS A . n 
A 1 237 TYR 237 237 237 TYR TYR A . n 
A 1 238 ASN 238 238 238 ASN ASN A . n 
A 1 239 TYR 239 239 239 TYR TYR A . n 
A 1 240 GLU 240 240 240 GLU GLU A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 THR 243 243 243 THR THR A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 ASP 248 248 248 ASP ASP A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 THR 257 257 257 THR THR A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 CYS 265 265 265 CYS CYS A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 LYS 269 269 269 LYS LYS A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 ASN 274 274 274 ASN ASN A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 ASN 277 277 277 ASN ASN A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 SER 284 284 284 SER SER A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 PHE 291 291 291 PHE PHE A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 PRO 293 293 293 PRO PRO A . n 
A 1 294 PHE 294 294 294 PHE PHE A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 VAL 296 296 296 VAL VAL A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLN 299 299 299 GLN GLN A . n 
A 1 300 CYS 300 300 300 CYS CYS A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 GLY 302 302 302 GLY GLY A . n 
A 1 303 VAL 303 303 303 VAL VAL A . n 
A 1 304 THR 304 304 304 THR THR A . n 
A 1 305 PHE 305 305 305 PHE PHE A . n 
A 1 306 GLN 306 306 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1ALL 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1ALL 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 A1ALL 1   401 401 A1ALL LIG A . 
C 3 HOH   1   501 16  HOH   HOH A . 
C 3 HOH   2   502 64  HOH   HOH A . 
C 3 HOH   3   503 32  HOH   HOH A . 
C 3 HOH   4   504 15  HOH   HOH A . 
C 3 HOH   5   505 59  HOH   HOH A . 
C 3 HOH   6   506 52  HOH   HOH A . 
C 3 HOH   7   507 13  HOH   HOH A . 
C 3 HOH   8   508 105 HOH   HOH A . 
C 3 HOH   9   509 12  HOH   HOH A . 
C 3 HOH   10  510 24  HOH   HOH A . 
C 3 HOH   11  511 103 HOH   HOH A . 
C 3 HOH   12  512 153 HOH   HOH A . 
C 3 HOH   13  513 99  HOH   HOH A . 
C 3 HOH   14  514 1   HOH   HOH A . 
C 3 HOH   15  515 60  HOH   HOH A . 
C 3 HOH   16  516 101 HOH   HOH A . 
C 3 HOH   17  517 87  HOH   HOH A . 
C 3 HOH   18  518 36  HOH   HOH A . 
C 3 HOH   19  519 83  HOH   HOH A . 
C 3 HOH   20  520 90  HOH   HOH A . 
C 3 HOH   21  521 77  HOH   HOH A . 
C 3 HOH   22  522 138 HOH   HOH A . 
C 3 HOH   23  523 136 HOH   HOH A . 
C 3 HOH   24  524 72  HOH   HOH A . 
C 3 HOH   25  525 69  HOH   HOH A . 
C 3 HOH   26  526 173 HOH   HOH A . 
C 3 HOH   27  527 71  HOH   HOH A . 
C 3 HOH   28  528 114 HOH   HOH A . 
C 3 HOH   29  529 5   HOH   HOH A . 
C 3 HOH   30  530 79  HOH   HOH A . 
C 3 HOH   31  531 81  HOH   HOH A . 
C 3 HOH   32  532 40  HOH   HOH A . 
C 3 HOH   33  533 130 HOH   HOH A . 
C 3 HOH   34  534 4   HOH   HOH A . 
C 3 HOH   35  535 143 HOH   HOH A . 
C 3 HOH   36  536 10  HOH   HOH A . 
C 3 HOH   37  537 120 HOH   HOH A . 
C 3 HOH   38  538 112 HOH   HOH A . 
C 3 HOH   39  539 106 HOH   HOH A . 
C 3 HOH   40  540 19  HOH   HOH A . 
C 3 HOH   41  541 2   HOH   HOH A . 
C 3 HOH   42  542 21  HOH   HOH A . 
C 3 HOH   43  543 17  HOH   HOH A . 
C 3 HOH   44  544 160 HOH   HOH A . 
C 3 HOH   45  545 20  HOH   HOH A . 
C 3 HOH   46  546 37  HOH   HOH A . 
C 3 HOH   47  547 6   HOH   HOH A . 
C 3 HOH   48  548 63  HOH   HOH A . 
C 3 HOH   49  549 127 HOH   HOH A . 
C 3 HOH   50  550 58  HOH   HOH A . 
C 3 HOH   51  551 41  HOH   HOH A . 
C 3 HOH   52  552 8   HOH   HOH A . 
C 3 HOH   53  553 35  HOH   HOH A . 
C 3 HOH   54  554 31  HOH   HOH A . 
C 3 HOH   55  555 118 HOH   HOH A . 
C 3 HOH   56  556 7   HOH   HOH A . 
C 3 HOH   57  557 23  HOH   HOH A . 
C 3 HOH   58  558 27  HOH   HOH A . 
C 3 HOH   59  559 67  HOH   HOH A . 
C 3 HOH   60  560 29  HOH   HOH A . 
C 3 HOH   61  561 144 HOH   HOH A . 
C 3 HOH   62  562 3   HOH   HOH A . 
C 3 HOH   63  563 43  HOH   HOH A . 
C 3 HOH   64  564 50  HOH   HOH A . 
C 3 HOH   65  565 70  HOH   HOH A . 
C 3 HOH   66  566 142 HOH   HOH A . 
C 3 HOH   67  567 154 HOH   HOH A . 
C 3 HOH   68  568 28  HOH   HOH A . 
C 3 HOH   69  569 62  HOH   HOH A . 
C 3 HOH   70  570 75  HOH   HOH A . 
C 3 HOH   71  571 26  HOH   HOH A . 
C 3 HOH   72  572 38  HOH   HOH A . 
C 3 HOH   73  573 22  HOH   HOH A . 
C 3 HOH   74  574 65  HOH   HOH A . 
C 3 HOH   75  575 73  HOH   HOH A . 
C 3 HOH   76  576 92  HOH   HOH A . 
C 3 HOH   77  577 68  HOH   HOH A . 
C 3 HOH   78  578 158 HOH   HOH A . 
C 3 HOH   79  579 147 HOH   HOH A . 
C 3 HOH   80  580 11  HOH   HOH A . 
C 3 HOH   81  581 14  HOH   HOH A . 
C 3 HOH   82  582 125 HOH   HOH A . 
C 3 HOH   83  583 61  HOH   HOH A . 
C 3 HOH   84  584 46  HOH   HOH A . 
C 3 HOH   85  585 80  HOH   HOH A . 
C 3 HOH   86  586 164 HOH   HOH A . 
C 3 HOH   87  587 159 HOH   HOH A . 
C 3 HOH   88  588 48  HOH   HOH A . 
C 3 HOH   89  589 18  HOH   HOH A . 
C 3 HOH   90  590 45  HOH   HOH A . 
C 3 HOH   91  591 148 HOH   HOH A . 
C 3 HOH   92  592 49  HOH   HOH A . 
C 3 HOH   93  593 9   HOH   HOH A . 
C 3 HOH   94  594 39  HOH   HOH A . 
C 3 HOH   95  595 47  HOH   HOH A . 
C 3 HOH   96  596 122 HOH   HOH A . 
C 3 HOH   97  597 93  HOH   HOH A . 
C 3 HOH   98  598 78  HOH   HOH A . 
C 3 HOH   99  599 113 HOH   HOH A . 
C 3 HOH   100 600 88  HOH   HOH A . 
C 3 HOH   101 601 121 HOH   HOH A . 
C 3 HOH   102 602 51  HOH   HOH A . 
C 3 HOH   103 603 133 HOH   HOH A . 
C 3 HOH   104 604 102 HOH   HOH A . 
C 3 HOH   105 605 34  HOH   HOH A . 
C 3 HOH   106 606 86  HOH   HOH A . 
C 3 HOH   107 607 74  HOH   HOH A . 
C 3 HOH   108 608 95  HOH   HOH A . 
C 3 HOH   109 609 66  HOH   HOH A . 
C 3 HOH   110 610 42  HOH   HOH A . 
C 3 HOH   111 611 82  HOH   HOH A . 
C 3 HOH   112 612 111 HOH   HOH A . 
C 3 HOH   113 613 25  HOH   HOH A . 
C 3 HOH   114 614 129 HOH   HOH A . 
C 3 HOH   115 615 109 HOH   HOH A . 
C 3 HOH   116 616 123 HOH   HOH A . 
C 3 HOH   117 617 108 HOH   HOH A . 
C 3 HOH   118 618 89  HOH   HOH A . 
C 3 HOH   119 619 110 HOH   HOH A . 
C 3 HOH   120 620 141 HOH   HOH A . 
C 3 HOH   121 621 54  HOH   HOH A . 
C 3 HOH   122 622 94  HOH   HOH A . 
C 3 HOH   123 623 84  HOH   HOH A . 
C 3 HOH   124 624 57  HOH   HOH A . 
C 3 HOH   125 625 140 HOH   HOH A . 
C 3 HOH   126 626 139 HOH   HOH A . 
C 3 HOH   127 627 176 HOH   HOH A . 
C 3 HOH   128 628 124 HOH   HOH A . 
C 3 HOH   129 629 172 HOH   HOH A . 
C 3 HOH   130 630 171 HOH   HOH A . 
C 3 HOH   131 631 135 HOH   HOH A . 
C 3 HOH   132 632 131 HOH   HOH A . 
C 3 HOH   133 633 55  HOH   HOH A . 
C 3 HOH   134 634 169 HOH   HOH A . 
C 3 HOH   135 635 107 HOH   HOH A . 
C 3 HOH   136 636 30  HOH   HOH A . 
C 3 HOH   137 637 33  HOH   HOH A . 
C 3 HOH   138 638 170 HOH   HOH A . 
C 3 HOH   139 639 117 HOH   HOH A . 
C 3 HOH   140 640 175 HOH   HOH A . 
C 3 HOH   141 641 174 HOH   HOH A . 
C 3 HOH   142 642 115 HOH   HOH A . 
C 3 HOH   143 643 132 HOH   HOH A . 
C 3 HOH   144 644 146 HOH   HOH A . 
C 3 HOH   145 645 134 HOH   HOH A . 
C 3 HOH   146 646 157 HOH   HOH A . 
C 3 HOH   147 647 53  HOH   HOH A . 
C 3 HOH   148 648 168 HOH   HOH A . 
C 3 HOH   149 649 156 HOH   HOH A . 
C 3 HOH   150 650 98  HOH   HOH A . 
C 3 HOH   151 651 44  HOH   HOH A . 
C 3 HOH   152 652 126 HOH   HOH A . 
C 3 HOH   153 653 128 HOH   HOH A . 
C 3 HOH   154 654 76  HOH   HOH A . 
C 3 HOH   155 655 96  HOH   HOH A . 
C 3 HOH   156 656 100 HOH   HOH A . 
C 3 HOH   157 657 91  HOH   HOH A . 
C 3 HOH   158 658 85  HOH   HOH A . 
C 3 HOH   159 659 165 HOH   HOH A . 
C 3 HOH   160 660 149 HOH   HOH A . 
C 3 HOH   161 661 167 HOH   HOH A . 
C 3 HOH   162 662 116 HOH   HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A GLU 47 ? CG  ? A GLU 47 CG  
2 1 Y 1 A GLU 47 ? CD  ? A GLU 47 CD  
3 1 Y 1 A GLU 47 ? OE1 ? A GLU 47 OE1 
4 1 Y 1 A GLU 47 ? OE2 ? A GLU 47 OE2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.21_5207 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .         2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .         3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .         4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BBR 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     45.577 
_cell.length_a_esd                 ? 
_cell.length_b                     63.979 
_cell.length_b_esd                 ? 
_cell.length_c                     104.835 
_cell.length_c_esd                 ? 
_cell.volume                       305695.808 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BBR 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                18 
_symmetry.space_group_name_Hall            'P 2 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BBR 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.26 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          45.56 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
'1% w/v Tryptone, 0.001 M Sodium azide, 0.05 M HEPES sodium pH 7.0, 12% w/v Polyethylene glycol 3,350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-10-10 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.979 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'APS BEAMLINE 24-ID-E' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.979 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   24-ID-E 
_diffrn_source.pdbx_synchrotron_site       APS 
# 
_reflns.B_iso_Wilson_estimate                          25.27 
_reflns.entry_id                                       9BBR 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.11 
_reflns.d_resolution_low                               104.83 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     18189 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.5 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                19.7 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          15.0 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.199 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.11 
_reflns_shell.d_res_low                                     2.17 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.0 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1392 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               0.367 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.601 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.524 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               26.84 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9BBR 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.15 
_refine.ls_d_res_low                             41.80 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     17060 
_refine.ls_number_reflns_R_free                  1706 
_refine.ls_number_reflns_R_work                  15354 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.54 
_refine.ls_percent_reflns_R_free                 10.00 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1712 
_refine.ls_R_factor_R_free                       0.2088 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1671 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.38 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 18.6053 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2144 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.15 
_refine_hist.d_res_low                        41.80 
_refine_hist.number_atoms_solvent             162 
_refine_hist.number_atoms_total               2550 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2354 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         34 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0083  ? 2443 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.9421  ? 3321 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0617  ? 373  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0070  ? 430  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 14.4360 ? 865  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.15 2.21  . . 135 1216 97.12 . . . . 0.1871 . . . . . . . . . . . 0.2638 
'X-RAY DIFFRACTION' 2.21 2.28  . . 142 1278 98.27 . . . . 0.1790 . . . . . . . . . . . 0.2513 
'X-RAY DIFFRACTION' 2.28 2.37  . . 136 1228 98.06 . . . . 0.1798 . . . . . . . . . . . 0.2500 
'X-RAY DIFFRACTION' 2.37 2.46  . . 141 1256 97.97 . . . . 0.1887 . . . . . . . . . . . 0.2519 
'X-RAY DIFFRACTION' 2.46 2.57  . . 138 1247 98.30 . . . . 0.1923 . . . . . . . . . . . 0.2278 
'X-RAY DIFFRACTION' 2.57 2.71  . . 141 1272 98.88 . . . . 0.1931 . . . . . . . . . . . 0.2755 
'X-RAY DIFFRACTION' 2.71 2.88  . . 140 1269 98.88 . . . . 0.1870 . . . . . . . . . . . 0.2530 
'X-RAY DIFFRACTION' 2.88 3.10  . . 142 1265 98.12 . . . . 0.1935 . . . . . . . . . . . 0.2089 
'X-RAY DIFFRACTION' 3.10 3.41  . . 143 1290 99.31 . . . . 0.1758 . . . . . . . . . . . 0.2182 
'X-RAY DIFFRACTION' 3.41 3.91  . . 146 1316 99.59 . . . . 0.1623 . . . . . . . . . . . 0.2016 
'X-RAY DIFFRACTION' 3.91 4.92  . . 147 1321 99.26 . . . . 0.1257 . . . . . . . . . . . 0.1578 
'X-RAY DIFFRACTION' 4.92 41.80 . . 155 1396 98.79 . . . . 0.1500 . . . . . . . . . . . 0.1596 
# 
_struct.entry_id                     9BBR 
_struct.title                        'SARS-CoV-2 Mpro in complex with compound 6b inhibitor' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BBR 
_struct_keywords.text            'Protease, Inhibitor, Complex, VIRAL PROTEIN, Hydrolase' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN, Hydrolase' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1AB_SARS2 
_struct_ref.pdbx_db_accession          P0DTD1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_struct_ref.pdbx_align_begin           3264 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9BBR 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 306 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P0DTD1 
_struct_ref_seq.db_align_beg                  3264 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3569 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       306 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 4790  ? 
1 MORE         -20   ? 
1 'SSA (A^2)'  24640 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  
0.0000000000 0.0000000000  0.0000000000 0.0000000000 1.0000000000 0.0000000000 
2 'crystal symmetry operation' 2_565 -x,-y+1,z -1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 
0.0000000000 63.9790000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 10  ? GLY A 15  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 41  ? CYS A 44  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 SER A 46  ? ASN A 51  ? SER A 46  ASN A 51  5 ? 6  
HELX_P HELX_P4  AA4 ASN A 53  ? ARG A 60  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P5  AA5 SER A 62  ? HIS A 64  ? SER A 62  HIS A 64  5 ? 3  
HELX_P HELX_P6  AA6 ILE A 200 ? ASN A 214 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P7  AA7 THR A 226 ? LYS A 236 ? THR A 226 LYS A 236 1 ? 11 
HELX_P HELX_P8  AA8 THR A 243 ? GLY A 258 ? THR A 243 GLY A 258 1 ? 16 
HELX_P HELX_P9  AA9 ALA A 260 ? GLY A 275 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P10 AB1 THR A 292 ? GLY A 302 ? THR A 292 GLY A 302 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            covale1 
_struct_conn.conn_type_id                  covale 
_struct_conn.pdbx_leaving_atom_flag        none 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            145 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           B 
_struct_conn.ptnr2_label_comp_id           A1ALL 
_struct_conn.ptnr2_label_seq_id            . 
_struct_conn.ptnr2_label_atom_id           C09 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             145 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            A1ALL 
_struct_conn.ptnr2_auth_seq_id             401 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               1.777 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      A1ALL 
_pdbx_modification_feature.label_asym_id                      B 
_pdbx_modification_feature.label_seq_id                       . 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      145 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       A1ALL 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        401 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       145 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               C09 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                CYS 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        A1ALL 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Covalent chemical modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 73  ? LEU A 75  ? VAL A 73  LEU A 75  
AA1 2 PHE A 66  ? ALA A 70  ? PHE A 66  ALA A 70  
AA1 3 MET A 17  ? CYS A 22  ? MET A 17  CYS A 22  
AA1 4 THR A 25  ? LEU A 32  ? THR A 25  LEU A 32  
AA1 5 VAL A 35  ? PRO A 39  ? VAL A 35  PRO A 39  
AA1 6 VAL A 86  ? VAL A 91  ? VAL A 86  VAL A 91  
AA1 7 VAL A 77  ? GLN A 83  ? VAL A 77  GLN A 83  
AA2 1 TYR A 101 ? PHE A 103 ? TYR A 101 PHE A 103 
AA2 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA2 3 VAL A 148 ? ASP A 153 ? VAL A 148 ASP A 153 
AA2 4 THR A 111 ? TYR A 118 ? THR A 111 TYR A 118 
AA2 5 SER A 121 ? ALA A 129 ? SER A 121 ALA A 129 
AA3 1 TYR A 101 ? PHE A 103 ? TYR A 101 PHE A 103 
AA3 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA3 3 HIS A 172 ? THR A 175 ? HIS A 172 THR A 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O LEU A 75  ? O LEU A 75  N VAL A 68  ? N VAL A 68  
AA1 2 3 O LEU A 67  ? O LEU A 67  N THR A 21  ? N THR A 21  
AA1 3 4 N VAL A 20  ? N VAL A 20  O LEU A 27  ? O LEU A 27  
AA1 4 5 N LEU A 32  ? N LEU A 32  O VAL A 35  ? O VAL A 35  
AA1 5 6 N CYS A 38  ? N CYS A 38  O LEU A 87  ? O LEU A 87  
AA1 6 7 O LYS A 90  ? O LYS A 90  N ILE A 78  ? N ILE A 78  
AA2 1 2 N LYS A 102 ? N LYS A 102 O PHE A 159 ? O PHE A 159 
AA2 2 3 O CYS A 156 ? O CYS A 156 N ASP A 153 ? N ASP A 153 
AA2 3 4 O PHE A 150 ? O PHE A 150 N SER A 113 ? N SER A 113 
AA2 4 5 N ALA A 116 ? N ALA A 116 O SER A 123 ? O SER A 123 
AA3 1 2 N LYS A 102 ? N LYS A 102 O PHE A 159 ? O PHE A 159 
AA3 2 3 N MET A 165 ? N MET A 165 O ALA A 173 ? O ALA A 173 
# 
_pdbx_entry_details.entry_id                   9BBR 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O   A HOH 606 ? ? O A HOH 633 ? ? 2.11 
2 1 NE2 A GLN 110 ? ? O A HOH 501 ? ? 2.16 
3 1 O   A HOH 626 ? ? O A HOH 632 ? ? 2.17 
4 1 OE2 A GLU 240 ? ? O A HOH 502 ? ? 2.18 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 55.02   -126.58 
2 1 ASN A 51  ? ? -160.27 75.65   
3 1 ASN A 84  ? ? 50.33   -118.54 
4 1 TYR A 154 ? ? 55.51   -93.03  
5 1 PRO A 184 ? ? -90.70  49.30   
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 651 ? C HOH . 
2 1 A HOH 661 ? C HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x+1/2,y+1/2,-z 
4 -x,-y,z         
# 
_pdbx_unobs_or_zero_occ_residues.id               1 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num    1 
_pdbx_unobs_or_zero_occ_residues.polymer_flag     Y 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag   1 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id     A 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id     GLN 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id      306 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code     ? 
_pdbx_unobs_or_zero_occ_residues.label_asym_id    A 
_pdbx_unobs_or_zero_occ_residues.label_comp_id    GLN 
_pdbx_unobs_or_zero_occ_residues.label_seq_id     306 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1ALL C13  C N R 1   
A1ALL C15  C N N 2   
A1ALL C17  C N N 3   
A1ALL C20  C Y N 4   
A1ALL C21  C Y N 5   
A1ALL C22  C Y N 6   
A1ALL C24  C Y N 7   
A1ALL C26  C Y N 8   
A1ALL C02  C N N 9   
A1ALL C04  C N N 10  
A1ALL C05  C N N 11  
A1ALL C06  C N S 12  
A1ALL C07  C N N 13  
A1ALL C08  C N S 14  
A1ALL C09  C N N 15  
A1ALL C12  C N N 16  
A1ALL C14  C N N 17  
A1ALL C16  C N N 18  
A1ALL C19  C N N 19  
A1ALL C23  C Y N 20  
A1ALL C25  C Y N 21  
A1ALL C27  C Y N 22  
A1ALL C29  C Y N 23  
A1ALL C30  C Y N 24  
A1ALL C31  C Y N 25  
A1ALL C32  C Y N 26  
A1ALL F28  F N N 27  
A1ALL N03  N N N 28  
A1ALL N10  N N N 29  
A1ALL N11  N N N 30  
A1ALL N18  N N N 31  
A1ALL O01  O N N 32  
A1ALL O33  O N N 33  
A1ALL O34  O N N 34  
A1ALL H131 H N N 35  
A1ALL H151 H N N 36  
A1ALL H172 H N N 37  
A1ALL H173 H N N 38  
A1ALL H171 H N N 39  
A1ALL H211 H N N 40  
A1ALL H221 H N N 41  
A1ALL H261 H N N 42  
A1ALL H042 H N N 43  
A1ALL H041 H N N 44  
A1ALL H052 H N N 45  
A1ALL H051 H N N 46  
A1ALL H061 H N N 47  
A1ALL H071 H N N 48  
A1ALL H072 H N N 49  
A1ALL H081 H N N 50  
A1ALL H091 H N N 51  
A1ALL H142 H N N 52  
A1ALL H141 H N N 53  
A1ALL H163 H N N 54  
A1ALL H162 H N N 55  
A1ALL H161 H N N 56  
A1ALL H251 H N N 57  
A1ALL H291 H N N 58  
A1ALL H301 H N N 59  
A1ALL H311 H N N 60  
A1ALL H321 H N N 61  
A1ALL H031 H N N 62  
A1ALL H101 H N N 63  
A1ALL H111 H N N 64  
A1ALL H181 H N N 65  
ALA   N    N N N 66  
ALA   CA   C N S 67  
ALA   C    C N N 68  
ALA   O    O N N 69  
ALA   CB   C N N 70  
ALA   OXT  O N N 71  
ALA   H    H N N 72  
ALA   H2   H N N 73  
ALA   HA   H N N 74  
ALA   HB1  H N N 75  
ALA   HB2  H N N 76  
ALA   HB3  H N N 77  
ALA   HXT  H N N 78  
ARG   N    N N N 79  
ARG   CA   C N S 80  
ARG   C    C N N 81  
ARG   O    O N N 82  
ARG   CB   C N N 83  
ARG   CG   C N N 84  
ARG   CD   C N N 85  
ARG   NE   N N N 86  
ARG   CZ   C N N 87  
ARG   NH1  N N N 88  
ARG   NH2  N N N 89  
ARG   OXT  O N N 90  
ARG   H    H N N 91  
ARG   H2   H N N 92  
ARG   HA   H N N 93  
ARG   HB2  H N N 94  
ARG   HB3  H N N 95  
ARG   HG2  H N N 96  
ARG   HG3  H N N 97  
ARG   HD2  H N N 98  
ARG   HD3  H N N 99  
ARG   HE   H N N 100 
ARG   HH11 H N N 101 
ARG   HH12 H N N 102 
ARG   HH21 H N N 103 
ARG   HH22 H N N 104 
ARG   HXT  H N N 105 
ASN   N    N N N 106 
ASN   CA   C N S 107 
ASN   C    C N N 108 
ASN   O    O N N 109 
ASN   CB   C N N 110 
ASN   CG   C N N 111 
ASN   OD1  O N N 112 
ASN   ND2  N N N 113 
ASN   OXT  O N N 114 
ASN   H    H N N 115 
ASN   H2   H N N 116 
ASN   HA   H N N 117 
ASN   HB2  H N N 118 
ASN   HB3  H N N 119 
ASN   HD21 H N N 120 
ASN   HD22 H N N 121 
ASN   HXT  H N N 122 
ASP   N    N N N 123 
ASP   CA   C N S 124 
ASP   C    C N N 125 
ASP   O    O N N 126 
ASP   CB   C N N 127 
ASP   CG   C N N 128 
ASP   OD1  O N N 129 
ASP   OD2  O N N 130 
ASP   OXT  O N N 131 
ASP   H    H N N 132 
ASP   H2   H N N 133 
ASP   HA   H N N 134 
ASP   HB2  H N N 135 
ASP   HB3  H N N 136 
ASP   HD2  H N N 137 
ASP   HXT  H N N 138 
CYS   N    N N N 139 
CYS   CA   C N R 140 
CYS   C    C N N 141 
CYS   O    O N N 142 
CYS   CB   C N N 143 
CYS   SG   S N N 144 
CYS   OXT  O N N 145 
CYS   H    H N N 146 
CYS   H2   H N N 147 
CYS   HA   H N N 148 
CYS   HB2  H N N 149 
CYS   HB3  H N N 150 
CYS   HG   H N N 151 
CYS   HXT  H N N 152 
GLN   N    N N N 153 
GLN   CA   C N S 154 
GLN   C    C N N 155 
GLN   O    O N N 156 
GLN   CB   C N N 157 
GLN   CG   C N N 158 
GLN   CD   C N N 159 
GLN   OE1  O N N 160 
GLN   NE2  N N N 161 
GLN   OXT  O N N 162 
GLN   H    H N N 163 
GLN   H2   H N N 164 
GLN   HA   H N N 165 
GLN   HB2  H N N 166 
GLN   HB3  H N N 167 
GLN   HG2  H N N 168 
GLN   HG3  H N N 169 
GLN   HE21 H N N 170 
GLN   HE22 H N N 171 
GLN   HXT  H N N 172 
GLU   N    N N N 173 
GLU   CA   C N S 174 
GLU   C    C N N 175 
GLU   O    O N N 176 
GLU   CB   C N N 177 
GLU   CG   C N N 178 
GLU   CD   C N N 179 
GLU   OE1  O N N 180 
GLU   OE2  O N N 181 
GLU   OXT  O N N 182 
GLU   H    H N N 183 
GLU   H2   H N N 184 
GLU   HA   H N N 185 
GLU   HB2  H N N 186 
GLU   HB3  H N N 187 
GLU   HG2  H N N 188 
GLU   HG3  H N N 189 
GLU   HE2  H N N 190 
GLU   HXT  H N N 191 
GLY   N    N N N 192 
GLY   CA   C N N 193 
GLY   C    C N N 194 
GLY   O    O N N 195 
GLY   OXT  O N N 196 
GLY   H    H N N 197 
GLY   H2   H N N 198 
GLY   HA2  H N N 199 
GLY   HA3  H N N 200 
GLY   HXT  H N N 201 
HIS   N    N N N 202 
HIS   CA   C N S 203 
HIS   C    C N N 204 
HIS   O    O N N 205 
HIS   CB   C N N 206 
HIS   CG   C Y N 207 
HIS   ND1  N Y N 208 
HIS   CD2  C Y N 209 
HIS   CE1  C Y N 210 
HIS   NE2  N Y N 211 
HIS   OXT  O N N 212 
HIS   H    H N N 213 
HIS   H2   H N N 214 
HIS   HA   H N N 215 
HIS   HB2  H N N 216 
HIS   HB3  H N N 217 
HIS   HD1  H N N 218 
HIS   HD2  H N N 219 
HIS   HE1  H N N 220 
HIS   HE2  H N N 221 
HIS   HXT  H N N 222 
HOH   O    O N N 223 
HOH   H1   H N N 224 
HOH   H2   H N N 225 
ILE   N    N N N 226 
ILE   CA   C N S 227 
ILE   C    C N N 228 
ILE   O    O N N 229 
ILE   CB   C N S 230 
ILE   CG1  C N N 231 
ILE   CG2  C N N 232 
ILE   CD1  C N N 233 
ILE   OXT  O N N 234 
ILE   H    H N N 235 
ILE   H2   H N N 236 
ILE   HA   H N N 237 
ILE   HB   H N N 238 
ILE   HG12 H N N 239 
ILE   HG13 H N N 240 
ILE   HG21 H N N 241 
ILE   HG22 H N N 242 
ILE   HG23 H N N 243 
ILE   HD11 H N N 244 
ILE   HD12 H N N 245 
ILE   HD13 H N N 246 
ILE   HXT  H N N 247 
LEU   N    N N N 248 
LEU   CA   C N S 249 
LEU   C    C N N 250 
LEU   O    O N N 251 
LEU   CB   C N N 252 
LEU   CG   C N N 253 
LEU   CD1  C N N 254 
LEU   CD2  C N N 255 
LEU   OXT  O N N 256 
LEU   H    H N N 257 
LEU   H2   H N N 258 
LEU   HA   H N N 259 
LEU   HB2  H N N 260 
LEU   HB3  H N N 261 
LEU   HG   H N N 262 
LEU   HD11 H N N 263 
LEU   HD12 H N N 264 
LEU   HD13 H N N 265 
LEU   HD21 H N N 266 
LEU   HD22 H N N 267 
LEU   HD23 H N N 268 
LEU   HXT  H N N 269 
LYS   N    N N N 270 
LYS   CA   C N S 271 
LYS   C    C N N 272 
LYS   O    O N N 273 
LYS   CB   C N N 274 
LYS   CG   C N N 275 
LYS   CD   C N N 276 
LYS   CE   C N N 277 
LYS   NZ   N N N 278 
LYS   OXT  O N N 279 
LYS   H    H N N 280 
LYS   H2   H N N 281 
LYS   HA   H N N 282 
LYS   HB2  H N N 283 
LYS   HB3  H N N 284 
LYS   HG2  H N N 285 
LYS   HG3  H N N 286 
LYS   HD2  H N N 287 
LYS   HD3  H N N 288 
LYS   HE2  H N N 289 
LYS   HE3  H N N 290 
LYS   HZ1  H N N 291 
LYS   HZ2  H N N 292 
LYS   HZ3  H N N 293 
LYS   HXT  H N N 294 
MET   N    N N N 295 
MET   CA   C N S 296 
MET   C    C N N 297 
MET   O    O N N 298 
MET   CB   C N N 299 
MET   CG   C N N 300 
MET   SD   S N N 301 
MET   CE   C N N 302 
MET   OXT  O N N 303 
MET   H    H N N 304 
MET   H2   H N N 305 
MET   HA   H N N 306 
MET   HB2  H N N 307 
MET   HB3  H N N 308 
MET   HG2  H N N 309 
MET   HG3  H N N 310 
MET   HE1  H N N 311 
MET   HE2  H N N 312 
MET   HE3  H N N 313 
MET   HXT  H N N 314 
PHE   N    N N N 315 
PHE   CA   C N S 316 
PHE   C    C N N 317 
PHE   O    O N N 318 
PHE   CB   C N N 319 
PHE   CG   C Y N 320 
PHE   CD1  C Y N 321 
PHE   CD2  C Y N 322 
PHE   CE1  C Y N 323 
PHE   CE2  C Y N 324 
PHE   CZ   C Y N 325 
PHE   OXT  O N N 326 
PHE   H    H N N 327 
PHE   H2   H N N 328 
PHE   HA   H N N 329 
PHE   HB2  H N N 330 
PHE   HB3  H N N 331 
PHE   HD1  H N N 332 
PHE   HD2  H N N 333 
PHE   HE1  H N N 334 
PHE   HE2  H N N 335 
PHE   HZ   H N N 336 
PHE   HXT  H N N 337 
PRO   N    N N N 338 
PRO   CA   C N S 339 
PRO   C    C N N 340 
PRO   O    O N N 341 
PRO   CB   C N N 342 
PRO   CG   C N N 343 
PRO   CD   C N N 344 
PRO   OXT  O N N 345 
PRO   H    H N N 346 
PRO   HA   H N N 347 
PRO   HB2  H N N 348 
PRO   HB3  H N N 349 
PRO   HG2  H N N 350 
PRO   HG3  H N N 351 
PRO   HD2  H N N 352 
PRO   HD3  H N N 353 
PRO   HXT  H N N 354 
SER   N    N N N 355 
SER   CA   C N S 356 
SER   C    C N N 357 
SER   O    O N N 358 
SER   CB   C N N 359 
SER   OG   O N N 360 
SER   OXT  O N N 361 
SER   H    H N N 362 
SER   H2   H N N 363 
SER   HA   H N N 364 
SER   HB2  H N N 365 
SER   HB3  H N N 366 
SER   HG   H N N 367 
SER   HXT  H N N 368 
THR   N    N N N 369 
THR   CA   C N S 370 
THR   C    C N N 371 
THR   O    O N N 372 
THR   CB   C N R 373 
THR   OG1  O N N 374 
THR   CG2  C N N 375 
THR   OXT  O N N 376 
THR   H    H N N 377 
THR   H2   H N N 378 
THR   HA   H N N 379 
THR   HB   H N N 380 
THR   HG1  H N N 381 
THR   HG21 H N N 382 
THR   HG22 H N N 383 
THR   HG23 H N N 384 
THR   HXT  H N N 385 
TRP   N    N N N 386 
TRP   CA   C N S 387 
TRP   C    C N N 388 
TRP   O    O N N 389 
TRP   CB   C N N 390 
TRP   CG   C Y N 391 
TRP   CD1  C Y N 392 
TRP   CD2  C Y N 393 
TRP   NE1  N Y N 394 
TRP   CE2  C Y N 395 
TRP   CE3  C Y N 396 
TRP   CZ2  C Y N 397 
TRP   CZ3  C Y N 398 
TRP   CH2  C Y N 399 
TRP   OXT  O N N 400 
TRP   H    H N N 401 
TRP   H2   H N N 402 
TRP   HA   H N N 403 
TRP   HB2  H N N 404 
TRP   HB3  H N N 405 
TRP   HD1  H N N 406 
TRP   HE1  H N N 407 
TRP   HE3  H N N 408 
TRP   HZ2  H N N 409 
TRP   HZ3  H N N 410 
TRP   HH2  H N N 411 
TRP   HXT  H N N 412 
TYR   N    N N N 413 
TYR   CA   C N S 414 
TYR   C    C N N 415 
TYR   O    O N N 416 
TYR   CB   C N N 417 
TYR   CG   C Y N 418 
TYR   CD1  C Y N 419 
TYR   CD2  C Y N 420 
TYR   CE1  C Y N 421 
TYR   CE2  C Y N 422 
TYR   CZ   C Y N 423 
TYR   OH   O N N 424 
TYR   OXT  O N N 425 
TYR   H    H N N 426 
TYR   H2   H N N 427 
TYR   HA   H N N 428 
TYR   HB2  H N N 429 
TYR   HB3  H N N 430 
TYR   HD1  H N N 431 
TYR   HD2  H N N 432 
TYR   HE1  H N N 433 
TYR   HE2  H N N 434 
TYR   HH   H N N 435 
TYR   HXT  H N N 436 
VAL   N    N N N 437 
VAL   CA   C N S 438 
VAL   C    C N N 439 
VAL   O    O N N 440 
VAL   CB   C N N 441 
VAL   CG1  C N N 442 
VAL   CG2  C N N 443 
VAL   OXT  O N N 444 
VAL   H    H N N 445 
VAL   H2   H N N 446 
VAL   HA   H N N 447 
VAL   HB   H N N 448 
VAL   HG11 H N N 449 
VAL   HG12 H N N 450 
VAL   HG13 H N N 451 
VAL   HG21 H N N 452 
VAL   HG22 H N N 453 
VAL   HG23 H N N 454 
VAL   HXT  H N N 455 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1ALL C02 O01  doub N N 1   
A1ALL N03 C02  sing N N 2   
A1ALL C04 N03  sing N N 3   
A1ALL C05 C04  sing N N 4   
A1ALL C06 C05  sing N N 5   
A1ALL C07 C06  sing N N 6   
A1ALL C08 C07  sing N N 7   
A1ALL N10 C09  doub N N 8   
A1ALL C09 C08  sing N N 9   
A1ALL N11 C08  sing N N 10  
A1ALL C12 N11  sing N N 11  
A1ALL C15 C14  sing N N 12  
A1ALL C16 C15  sing N N 13  
A1ALL C17 C15  sing N N 14  
A1ALL C14 C13  sing N N 15  
A1ALL N18 C13  sing N N 16  
A1ALL C19 N18  sing N N 17  
A1ALL C21 C20  doub Y N 18  
A1ALL C22 C21  sing Y N 19  
A1ALL C23 C22  doub Y N 20  
A1ALL C25 C24  doub Y N 21  
A1ALL C26 C25  sing Y N 22  
A1ALL C27 C26  doub Y N 23  
A1ALL F28 C27  sing N N 24  
A1ALL C29 C27  sing Y N 25  
A1ALL C30 C29  doub Y N 26  
A1ALL C24 C23  sing N N 27  
A1ALL C31 C23  sing Y N 28  
A1ALL C32 C31  doub Y N 29  
A1ALL C20 C19  sing N N 30  
A1ALL O33 C19  doub N N 31  
A1ALL C13 C12  sing N N 32  
A1ALL O34 C12  doub N N 33  
A1ALL C02 C06  sing N N 34  
A1ALL C20 C32  sing Y N 35  
A1ALL C24 C30  sing Y N 36  
A1ALL C13 H131 sing N N 37  
A1ALL C15 H151 sing N N 38  
A1ALL C17 H172 sing N N 39  
A1ALL C17 H173 sing N N 40  
A1ALL C17 H171 sing N N 41  
A1ALL C21 H211 sing N N 42  
A1ALL C22 H221 sing N N 43  
A1ALL C26 H261 sing N N 44  
A1ALL C04 H042 sing N N 45  
A1ALL C04 H041 sing N N 46  
A1ALL C05 H052 sing N N 47  
A1ALL C05 H051 sing N N 48  
A1ALL C06 H061 sing N N 49  
A1ALL C07 H071 sing N N 50  
A1ALL C07 H072 sing N N 51  
A1ALL C08 H081 sing N N 52  
A1ALL C09 H091 sing N N 53  
A1ALL C14 H142 sing N N 54  
A1ALL C14 H141 sing N N 55  
A1ALL C16 H163 sing N N 56  
A1ALL C16 H162 sing N N 57  
A1ALL C16 H161 sing N N 58  
A1ALL C25 H251 sing N N 59  
A1ALL C29 H291 sing N N 60  
A1ALL C30 H301 sing N N 61  
A1ALL C31 H311 sing N N 62  
A1ALL C32 H321 sing N N 63  
A1ALL N03 H031 sing N N 64  
A1ALL N10 H101 sing N N 65  
A1ALL N11 H111 sing N N 66  
A1ALL N18 H181 sing N N 67  
ALA   N   CA   sing N N 68  
ALA   N   H    sing N N 69  
ALA   N   H2   sing N N 70  
ALA   CA  C    sing N N 71  
ALA   CA  CB   sing N N 72  
ALA   CA  HA   sing N N 73  
ALA   C   O    doub N N 74  
ALA   C   OXT  sing N N 75  
ALA   CB  HB1  sing N N 76  
ALA   CB  HB2  sing N N 77  
ALA   CB  HB3  sing N N 78  
ALA   OXT HXT  sing N N 79  
ARG   N   CA   sing N N 80  
ARG   N   H    sing N N 81  
ARG   N   H2   sing N N 82  
ARG   CA  C    sing N N 83  
ARG   CA  CB   sing N N 84  
ARG   CA  HA   sing N N 85  
ARG   C   O    doub N N 86  
ARG   C   OXT  sing N N 87  
ARG   CB  CG   sing N N 88  
ARG   CB  HB2  sing N N 89  
ARG   CB  HB3  sing N N 90  
ARG   CG  CD   sing N N 91  
ARG   CG  HG2  sing N N 92  
ARG   CG  HG3  sing N N 93  
ARG   CD  NE   sing N N 94  
ARG   CD  HD2  sing N N 95  
ARG   CD  HD3  sing N N 96  
ARG   NE  CZ   sing N N 97  
ARG   NE  HE   sing N N 98  
ARG   CZ  NH1  sing N N 99  
ARG   CZ  NH2  doub N N 100 
ARG   NH1 HH11 sing N N 101 
ARG   NH1 HH12 sing N N 102 
ARG   NH2 HH21 sing N N 103 
ARG   NH2 HH22 sing N N 104 
ARG   OXT HXT  sing N N 105 
ASN   N   CA   sing N N 106 
ASN   N   H    sing N N 107 
ASN   N   H2   sing N N 108 
ASN   CA  C    sing N N 109 
ASN   CA  CB   sing N N 110 
ASN   CA  HA   sing N N 111 
ASN   C   O    doub N N 112 
ASN   C   OXT  sing N N 113 
ASN   CB  CG   sing N N 114 
ASN   CB  HB2  sing N N 115 
ASN   CB  HB3  sing N N 116 
ASN   CG  OD1  doub N N 117 
ASN   CG  ND2  sing N N 118 
ASN   ND2 HD21 sing N N 119 
ASN   ND2 HD22 sing N N 120 
ASN   OXT HXT  sing N N 121 
ASP   N   CA   sing N N 122 
ASP   N   H    sing N N 123 
ASP   N   H2   sing N N 124 
ASP   CA  C    sing N N 125 
ASP   CA  CB   sing N N 126 
ASP   CA  HA   sing N N 127 
ASP   C   O    doub N N 128 
ASP   C   OXT  sing N N 129 
ASP   CB  CG   sing N N 130 
ASP   CB  HB2  sing N N 131 
ASP   CB  HB3  sing N N 132 
ASP   CG  OD1  doub N N 133 
ASP   CG  OD2  sing N N 134 
ASP   OD2 HD2  sing N N 135 
ASP   OXT HXT  sing N N 136 
CYS   N   CA   sing N N 137 
CYS   N   H    sing N N 138 
CYS   N   H2   sing N N 139 
CYS   CA  C    sing N N 140 
CYS   CA  CB   sing N N 141 
CYS   CA  HA   sing N N 142 
CYS   C   O    doub N N 143 
CYS   C   OXT  sing N N 144 
CYS   CB  SG   sing N N 145 
CYS   CB  HB2  sing N N 146 
CYS   CB  HB3  sing N N 147 
CYS   SG  HG   sing N N 148 
CYS   OXT HXT  sing N N 149 
GLN   N   CA   sing N N 150 
GLN   N   H    sing N N 151 
GLN   N   H2   sing N N 152 
GLN   CA  C    sing N N 153 
GLN   CA  CB   sing N N 154 
GLN   CA  HA   sing N N 155 
GLN   C   O    doub N N 156 
GLN   C   OXT  sing N N 157 
GLN   CB  CG   sing N N 158 
GLN   CB  HB2  sing N N 159 
GLN   CB  HB3  sing N N 160 
GLN   CG  CD   sing N N 161 
GLN   CG  HG2  sing N N 162 
GLN   CG  HG3  sing N N 163 
GLN   CD  OE1  doub N N 164 
GLN   CD  NE2  sing N N 165 
GLN   NE2 HE21 sing N N 166 
GLN   NE2 HE22 sing N N 167 
GLN   OXT HXT  sing N N 168 
GLU   N   CA   sing N N 169 
GLU   N   H    sing N N 170 
GLU   N   H2   sing N N 171 
GLU   CA  C    sing N N 172 
GLU   CA  CB   sing N N 173 
GLU   CA  HA   sing N N 174 
GLU   C   O    doub N N 175 
GLU   C   OXT  sing N N 176 
GLU   CB  CG   sing N N 177 
GLU   CB  HB2  sing N N 178 
GLU   CB  HB3  sing N N 179 
GLU   CG  CD   sing N N 180 
GLU   CG  HG2  sing N N 181 
GLU   CG  HG3  sing N N 182 
GLU   CD  OE1  doub N N 183 
GLU   CD  OE2  sing N N 184 
GLU   OE2 HE2  sing N N 185 
GLU   OXT HXT  sing N N 186 
GLY   N   CA   sing N N 187 
GLY   N   H    sing N N 188 
GLY   N   H2   sing N N 189 
GLY   CA  C    sing N N 190 
GLY   CA  HA2  sing N N 191 
GLY   CA  HA3  sing N N 192 
GLY   C   O    doub N N 193 
GLY   C   OXT  sing N N 194 
GLY   OXT HXT  sing N N 195 
HIS   N   CA   sing N N 196 
HIS   N   H    sing N N 197 
HIS   N   H2   sing N N 198 
HIS   CA  C    sing N N 199 
HIS   CA  CB   sing N N 200 
HIS   CA  HA   sing N N 201 
HIS   C   O    doub N N 202 
HIS   C   OXT  sing N N 203 
HIS   CB  CG   sing N N 204 
HIS   CB  HB2  sing N N 205 
HIS   CB  HB3  sing N N 206 
HIS   CG  ND1  sing Y N 207 
HIS   CG  CD2  doub Y N 208 
HIS   ND1 CE1  doub Y N 209 
HIS   ND1 HD1  sing N N 210 
HIS   CD2 NE2  sing Y N 211 
HIS   CD2 HD2  sing N N 212 
HIS   CE1 NE2  sing Y N 213 
HIS   CE1 HE1  sing N N 214 
HIS   NE2 HE2  sing N N 215 
HIS   OXT HXT  sing N N 216 
HOH   O   H1   sing N N 217 
HOH   O   H2   sing N N 218 
ILE   N   CA   sing N N 219 
ILE   N   H    sing N N 220 
ILE   N   H2   sing N N 221 
ILE   CA  C    sing N N 222 
ILE   CA  CB   sing N N 223 
ILE   CA  HA   sing N N 224 
ILE   C   O    doub N N 225 
ILE   C   OXT  sing N N 226 
ILE   CB  CG1  sing N N 227 
ILE   CB  CG2  sing N N 228 
ILE   CB  HB   sing N N 229 
ILE   CG1 CD1  sing N N 230 
ILE   CG1 HG12 sing N N 231 
ILE   CG1 HG13 sing N N 232 
ILE   CG2 HG21 sing N N 233 
ILE   CG2 HG22 sing N N 234 
ILE   CG2 HG23 sing N N 235 
ILE   CD1 HD11 sing N N 236 
ILE   CD1 HD12 sing N N 237 
ILE   CD1 HD13 sing N N 238 
ILE   OXT HXT  sing N N 239 
LEU   N   CA   sing N N 240 
LEU   N   H    sing N N 241 
LEU   N   H2   sing N N 242 
LEU   CA  C    sing N N 243 
LEU   CA  CB   sing N N 244 
LEU   CA  HA   sing N N 245 
LEU   C   O    doub N N 246 
LEU   C   OXT  sing N N 247 
LEU   CB  CG   sing N N 248 
LEU   CB  HB2  sing N N 249 
LEU   CB  HB3  sing N N 250 
LEU   CG  CD1  sing N N 251 
LEU   CG  CD2  sing N N 252 
LEU   CG  HG   sing N N 253 
LEU   CD1 HD11 sing N N 254 
LEU   CD1 HD12 sing N N 255 
LEU   CD1 HD13 sing N N 256 
LEU   CD2 HD21 sing N N 257 
LEU   CD2 HD22 sing N N 258 
LEU   CD2 HD23 sing N N 259 
LEU   OXT HXT  sing N N 260 
LYS   N   CA   sing N N 261 
LYS   N   H    sing N N 262 
LYS   N   H2   sing N N 263 
LYS   CA  C    sing N N 264 
LYS   CA  CB   sing N N 265 
LYS   CA  HA   sing N N 266 
LYS   C   O    doub N N 267 
LYS   C   OXT  sing N N 268 
LYS   CB  CG   sing N N 269 
LYS   CB  HB2  sing N N 270 
LYS   CB  HB3  sing N N 271 
LYS   CG  CD   sing N N 272 
LYS   CG  HG2  sing N N 273 
LYS   CG  HG3  sing N N 274 
LYS   CD  CE   sing N N 275 
LYS   CD  HD2  sing N N 276 
LYS   CD  HD3  sing N N 277 
LYS   CE  NZ   sing N N 278 
LYS   CE  HE2  sing N N 279 
LYS   CE  HE3  sing N N 280 
LYS   NZ  HZ1  sing N N 281 
LYS   NZ  HZ2  sing N N 282 
LYS   NZ  HZ3  sing N N 283 
LYS   OXT HXT  sing N N 284 
MET   N   CA   sing N N 285 
MET   N   H    sing N N 286 
MET   N   H2   sing N N 287 
MET   CA  C    sing N N 288 
MET   CA  CB   sing N N 289 
MET   CA  HA   sing N N 290 
MET   C   O    doub N N 291 
MET   C   OXT  sing N N 292 
MET   CB  CG   sing N N 293 
MET   CB  HB2  sing N N 294 
MET   CB  HB3  sing N N 295 
MET   CG  SD   sing N N 296 
MET   CG  HG2  sing N N 297 
MET   CG  HG3  sing N N 298 
MET   SD  CE   sing N N 299 
MET   CE  HE1  sing N N 300 
MET   CE  HE2  sing N N 301 
MET   CE  HE3  sing N N 302 
MET   OXT HXT  sing N N 303 
PHE   N   CA   sing N N 304 
PHE   N   H    sing N N 305 
PHE   N   H2   sing N N 306 
PHE   CA  C    sing N N 307 
PHE   CA  CB   sing N N 308 
PHE   CA  HA   sing N N 309 
PHE   C   O    doub N N 310 
PHE   C   OXT  sing N N 311 
PHE   CB  CG   sing N N 312 
PHE   CB  HB2  sing N N 313 
PHE   CB  HB3  sing N N 314 
PHE   CG  CD1  doub Y N 315 
PHE   CG  CD2  sing Y N 316 
PHE   CD1 CE1  sing Y N 317 
PHE   CD1 HD1  sing N N 318 
PHE   CD2 CE2  doub Y N 319 
PHE   CD2 HD2  sing N N 320 
PHE   CE1 CZ   doub Y N 321 
PHE   CE1 HE1  sing N N 322 
PHE   CE2 CZ   sing Y N 323 
PHE   CE2 HE2  sing N N 324 
PHE   CZ  HZ   sing N N 325 
PHE   OXT HXT  sing N N 326 
PRO   N   CA   sing N N 327 
PRO   N   CD   sing N N 328 
PRO   N   H    sing N N 329 
PRO   CA  C    sing N N 330 
PRO   CA  CB   sing N N 331 
PRO   CA  HA   sing N N 332 
PRO   C   O    doub N N 333 
PRO   C   OXT  sing N N 334 
PRO   CB  CG   sing N N 335 
PRO   CB  HB2  sing N N 336 
PRO   CB  HB3  sing N N 337 
PRO   CG  CD   sing N N 338 
PRO   CG  HG2  sing N N 339 
PRO   CG  HG3  sing N N 340 
PRO   CD  HD2  sing N N 341 
PRO   CD  HD3  sing N N 342 
PRO   OXT HXT  sing N N 343 
SER   N   CA   sing N N 344 
SER   N   H    sing N N 345 
SER   N   H2   sing N N 346 
SER   CA  C    sing N N 347 
SER   CA  CB   sing N N 348 
SER   CA  HA   sing N N 349 
SER   C   O    doub N N 350 
SER   C   OXT  sing N N 351 
SER   CB  OG   sing N N 352 
SER   CB  HB2  sing N N 353 
SER   CB  HB3  sing N N 354 
SER   OG  HG   sing N N 355 
SER   OXT HXT  sing N N 356 
THR   N   CA   sing N N 357 
THR   N   H    sing N N 358 
THR   N   H2   sing N N 359 
THR   CA  C    sing N N 360 
THR   CA  CB   sing N N 361 
THR   CA  HA   sing N N 362 
THR   C   O    doub N N 363 
THR   C   OXT  sing N N 364 
THR   CB  OG1  sing N N 365 
THR   CB  CG2  sing N N 366 
THR   CB  HB   sing N N 367 
THR   OG1 HG1  sing N N 368 
THR   CG2 HG21 sing N N 369 
THR   CG2 HG22 sing N N 370 
THR   CG2 HG23 sing N N 371 
THR   OXT HXT  sing N N 372 
TRP   N   CA   sing N N 373 
TRP   N   H    sing N N 374 
TRP   N   H2   sing N N 375 
TRP   CA  C    sing N N 376 
TRP   CA  CB   sing N N 377 
TRP   CA  HA   sing N N 378 
TRP   C   O    doub N N 379 
TRP   C   OXT  sing N N 380 
TRP   CB  CG   sing N N 381 
TRP   CB  HB2  sing N N 382 
TRP   CB  HB3  sing N N 383 
TRP   CG  CD1  doub Y N 384 
TRP   CG  CD2  sing Y N 385 
TRP   CD1 NE1  sing Y N 386 
TRP   CD1 HD1  sing N N 387 
TRP   CD2 CE2  doub Y N 388 
TRP   CD2 CE3  sing Y N 389 
TRP   NE1 CE2  sing Y N 390 
TRP   NE1 HE1  sing N N 391 
TRP   CE2 CZ2  sing Y N 392 
TRP   CE3 CZ3  doub Y N 393 
TRP   CE3 HE3  sing N N 394 
TRP   CZ2 CH2  doub Y N 395 
TRP   CZ2 HZ2  sing N N 396 
TRP   CZ3 CH2  sing Y N 397 
TRP   CZ3 HZ3  sing N N 398 
TRP   CH2 HH2  sing N N 399 
TRP   OXT HXT  sing N N 400 
TYR   N   CA   sing N N 401 
TYR   N   H    sing N N 402 
TYR   N   H2   sing N N 403 
TYR   CA  C    sing N N 404 
TYR   CA  CB   sing N N 405 
TYR   CA  HA   sing N N 406 
TYR   C   O    doub N N 407 
TYR   C   OXT  sing N N 408 
TYR   CB  CG   sing N N 409 
TYR   CB  HB2  sing N N 410 
TYR   CB  HB3  sing N N 411 
TYR   CG  CD1  doub Y N 412 
TYR   CG  CD2  sing Y N 413 
TYR   CD1 CE1  sing Y N 414 
TYR   CD1 HD1  sing N N 415 
TYR   CD2 CE2  doub Y N 416 
TYR   CD2 HD2  sing N N 417 
TYR   CE1 CZ   doub Y N 418 
TYR   CE1 HE1  sing N N 419 
TYR   CE2 CZ   sing Y N 420 
TYR   CE2 HE2  sing N N 421 
TYR   CZ  OH   sing N N 422 
TYR   OH  HH   sing N N 423 
TYR   OXT HXT  sing N N 424 
VAL   N   CA   sing N N 425 
VAL   N   H    sing N N 426 
VAL   N   H2   sing N N 427 
VAL   CA  C    sing N N 428 
VAL   CA  CB   sing N N 429 
VAL   CA  HA   sing N N 430 
VAL   C   O    doub N N 431 
VAL   C   OXT  sing N N 432 
VAL   CB  CG1  sing N N 433 
VAL   CB  CG2  sing N N 434 
VAL   CB  HB   sing N N 435 
VAL   CG1 HG11 sing N N 436 
VAL   CG1 HG12 sing N N 437 
VAL   CG1 HG13 sing N N 438 
VAL   CG2 HG21 sing N N 439 
VAL   CG2 HG22 sing N N 440 
VAL   CG2 HG23 sing N N 441 
VAL   OXT HXT  sing N N 442 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' R01GM115568 1 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' R01GM128731 2 
'Cancer Prevention and Research Institute of Texas (CPRIT)'                                'United States' RR200030    3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 2' 
_space_group.name_Hall        'P 2 2ab' 
_space_group.IT_number        18 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9BBR 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.021941 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.015630 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009539 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C   ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F   ? ? 4.90428 4.07044 ? ? 12.99538 1.63651  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N   ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O   ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O1- ? ? 5.12366 3.84317 ? ? 3.49406  27.47979 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S   ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . SER   A 1 1   ? 15.78956  38.91254 -21.49370 1.000 30.51696 ?  1   SER   A N   1 
ATOM   2    C CA  . SER   A 1 1   ? 15.31606  37.93897 -20.52194 1.000 28.65644 ?  1   SER   A CA  1 
ATOM   3    C C   . SER   A 1 1   ? 13.77630  37.93307 -20.38592 1.000 33.12109 ?  1   SER   A C   1 
ATOM   4    O O   . SER   A 1 1   ? 13.04443  38.40448 -21.27162 1.000 26.32074 ?  1   SER   A O   1 
ATOM   5    C CB  . SER   A 1 1   ? 15.96601  38.20362 -19.15973 1.000 32.26319 ?  1   SER   A CB  1 
ATOM   6    O OG  . SER   A 1 1   ? 15.34907  39.30580 -18.51087 1.000 42.32023 ?  1   SER   A OG  1 
ATOM   7    N N   . GLY   A 1 2   ? 13.28783  37.39060 -19.26653 1.000 32.17228 ?  2   GLY   A N   1 
ATOM   8    C CA  . GLY   A 1 2   ? 11.86337  37.20914 -19.06768 1.000 26.95293 ?  2   GLY   A CA  1 
ATOM   9    C C   . GLY   A 1 2   ? 11.46639  35.79338 -19.43425 1.000 27.53568 ?  2   GLY   A C   1 
ATOM   10   O O   . GLY   A 1 2   ? 12.09859  35.17430 -20.29942 1.000 27.44824 ?  2   GLY   A O   1 
ATOM   11   N N   . PHE   A 1 3   ? 10.44260  35.24612 -18.78333 1.000 24.86539 ?  3   PHE   A N   1 
ATOM   12   C CA  . PHE   A 1 3   ? 9.99839   33.89588 -19.09828 1.000 23.36969 ?  3   PHE   A CA  1 
ATOM   13   C C   . PHE   A 1 3   ? 8.48357   33.87113 -19.10642 1.000 23.52057 ?  3   PHE   A C   1 
ATOM   14   O O   . PHE   A 1 3   ? 7.84433   34.26275 -18.12956 1.000 24.20911 ?  3   PHE   A O   1 
ATOM   15   C CB  . PHE   A 1 3   ? 10.55067  32.87142 -18.11436 1.000 22.57089 ?  3   PHE   A CB  1 
ATOM   16   C CG  . PHE   A 1 3   ? 10.37650  31.44420 -18.57316 1.000 21.61515 ?  3   PHE   A CG  1 
ATOM   17   C CD1 . PHE   A 1 3   ? 11.20212  30.90979 -19.54303 1.000 20.48646 ?  3   PHE   A CD1 1 
ATOM   18   C CD2 . PHE   A 1 3   ? 9.38412   30.64459 -18.02948 1.000 23.78252 ?  3   PHE   A CD2 1 
ATOM   19   C CE1 . PHE   A 1 3   ? 11.04702  29.59760 -19.95506 1.000 23.79901 ?  3   PHE   A CE1 1 
ATOM   20   C CE2 . PHE   A 1 3   ? 9.22517   29.33233 -18.43696 1.000 23.74220 ?  3   PHE   A CE2 1 
ATOM   21   C CZ  . PHE   A 1 3   ? 10.05599  28.81231 -19.39716 1.000 20.18997 ?  3   PHE   A CZ  1 
ATOM   22   N N   . ARG   A 1 4   ? 7.91762   33.40411 -20.20603 1.000 25.01339 ?  4   ARG   A N   1 
ATOM   23   C CA  . ARG   A 1 4   ? 6.48405   33.43654 -20.42164 1.000 23.49597 ?  4   ARG   A CA  1 
ATOM   24   C C   . ARG   A 1 4   ? 6.04520   32.08850 -20.97263 1.000 23.41840 ?  4   ARG   A C   1 
ATOM   25   O O   . ARG   A 1 4   ? 6.77724   31.43516 -21.71518 1.000 22.36197 ?  4   ARG   A O   1 
ATOM   26   C CB  . ARG   A 1 4   ? 6.10583   34.54904 -21.40489 1.000 17.17783 ?  4   ARG   A CB  1 
ATOM   27   C CG  . ARG   A 1 4   ? 6.50591   35.93092 -20.93652 1.000 21.39670 ?  4   ARG   A CG  1 
ATOM   28   C CD  . ARG   A 1 4   ? 5.61007   36.34477 -19.80306 1.000 26.10993 ?  4   ARG   A CD  1 
ATOM   29   N NE  . ARG   A 1 4   ? 4.23249   35.97473 -20.12151 1.000 23.57626 ?  4   ARG   A NE  1 
ATOM   30   C CZ  . ARG   A 1 4   ? 3.36504   36.75875 -20.74640 1.000 25.63083 ?  4   ARG   A CZ  1 
ATOM   31   N NH1 . ARG   A 1 4   ? 3.68124   38.00300 -21.09216 1.000 24.30524 ?  4   ARG   A NH1 1 
ATOM   32   N NH2 . ARG   A 1 4   ? 2.14909   36.28293 -21.03194 1.000 20.63488 ?  4   ARG   A NH2 1 
ATOM   33   N N   . LYS   A 1 5   ? 4.85165   31.66734 -20.59171 1.000 24.52425 ?  5   LYS   A N   1 
ATOM   34   C CA  . LYS   A 1 5   ? 4.21943   30.57053 -21.30104 1.000 20.16907 ?  5   LYS   A CA  1 
ATOM   35   C C   . LYS   A 1 5   ? 3.98106   31.03384 -22.72878 1.000 21.71324 ?  5   LYS   A C   1 
ATOM   36   O O   . LYS   A 1 5   ? 3.28117   32.02787 -22.95789 1.000 21.45682 ?  5   LYS   A O   1 
ATOM   37   C CB  . LYS   A 1 5   ? 2.91229   30.18732 -20.62196 1.000 23.72952 ?  5   LYS   A CB  1 
ATOM   38   C CG  . LYS   A 1 5   ? 2.24054   29.00877 -21.25131 1.000 25.96113 ?  5   LYS   A CG  1 
ATOM   39   C CD  . LYS   A 1 5   ? 1.35476   28.32050 -20.22978 1.000 29.39446 ?  5   LYS   A CD  1 
ATOM   40   C CE  . LYS   A 1 5   ? 2.19603   27.69212 -19.12532 1.000 37.68003 ?  5   LYS   A CE  1 
ATOM   41   N NZ  . LYS   A 1 5   ? 1.35869   27.42085 -17.92025 1.000 35.77013 ?  5   LYS   A NZ  1 
ATOM   42   N N   . MET   A 1 6   ? 4.57789   30.36030 -23.69313 1.000 17.71455 ?  6   MET   A N   1 
ATOM   43   C CA  . MET   A 1 6   ? 4.48054   30.84359 -25.05528 1.000 21.59697 ?  6   MET   A CA  1 
ATOM   44   C C   . MET   A 1 6   ? 4.15016   29.68712 -25.98310 1.000 20.13269 ?  6   MET   A C   1 
ATOM   45   O O   . MET   A 1 6   ? 4.60994   28.55116 -25.78807 1.000 21.25231 ?  6   MET   A O   1 
ATOM   46   C CB  . MET   A 1 6   ? 5.76815   31.59987 -25.47026 1.000 25.04272 ?  6   MET   A CB  1 
ATOM   47   C CG  . MET   A 1 6   ? 6.90414   30.82145 -26.06129 1.000 25.82855 ?  6   MET   A CG  1 
ATOM   48   S SD  . MET   A 1 6   ? 8.20615   31.96464 -26.69710 1.000 34.00976 ?  6   MET   A SD  1 
ATOM   49   C CE  . MET   A 1 6   ? 8.40078   33.12965 -25.37351 1.000 27.87002 ?  6   MET   A CE  1 
ATOM   50   N N   . ALA   A 1 7   ? 3.28287   29.97167 -26.93540 1.000 15.61364 ?  7   ALA   A N   1 
ATOM   51   C CA  . ALA   A 1 7   ? 2.82255   28.97641 -27.88196 1.000 17.77880 ?  7   ALA   A CA  1 
ATOM   52   C C   . ALA   A 1 7   ? 3.64852   29.08910 -29.14610 1.000 18.01990 ?  7   ALA   A C   1 
ATOM   53   O O   . ALA   A 1 7   ? 4.32019   30.09525 -29.36992 1.000 18.56150 ?  7   ALA   A O   1 
ATOM   54   C CB  . ALA   A 1 7   ? 1.33889   29.17032 -28.19515 1.000 22.03458 ?  7   ALA   A CB  1 
ATOM   55   N N   . PHE   A 1 8   ? 3.61069   28.03428 -29.96002 1.000 15.77218 ?  8   PHE   A N   1 
ATOM   56   C CA  . PHE   A 1 8   ? 4.24615   28.07827 -31.26237 1.000 18.03536 ?  8   PHE   A CA  1 
ATOM   57   C C   . PHE   A 1 8   ? 3.48626   29.04440 -32.16580 1.000 18.05808 ?  8   PHE   A C   1 
ATOM   58   O O   . PHE   A 1 8   ? 2.26198   29.18345 -32.04404 1.000 16.06673 ?  8   PHE   A O   1 
ATOM   59   C CB  . PHE   A 1 8   ? 4.26133   26.69458 -31.91153 1.000 17.32722 ?  8   PHE   A CB  1 
ATOM   60   C CG  . PHE   A 1 8   ? 5.21126   25.72413 -31.26875 1.000 20.69012 ?  8   PHE   A CG  1 
ATOM   61   C CD1 . PHE   A 1 8   ? 6.54423   25.71125 -31.60682 1.000 21.16842 ?  8   PHE   A CD1 1 
ATOM   62   C CD2 . PHE   A 1 8   ? 4.75393   24.80337 -30.34102 1.000 23.37850 ?  8   PHE   A CD2 1 
ATOM   63   C CE1 . PHE   A 1 8   ? 7.41267   24.80548 -31.00388 1.000 27.72078 ?  8   PHE   A CE1 1 
ATOM   64   C CE2 . PHE   A 1 8   ? 5.60436   23.90386 -29.74019 1.000 21.44736 ?  8   PHE   A CE2 1 
ATOM   65   C CZ  . PHE   A 1 8   ? 6.94091   23.90338 -30.07846 1.000 27.61090 ?  8   PHE   A CZ  1 
ATOM   66   N N   . PRO   A 1 9   ? 4.18475   29.70813 -33.08854 1.000 16.15445 ?  9   PRO   A N   1 
ATOM   67   C CA  . PRO   A 1 9   ? 3.48114   30.45589 -34.14369 1.000 17.19551 ?  9   PRO   A CA  1 
ATOM   68   C C   . PRO   A 1 9   ? 2.52113   29.52273 -34.86859 1.000 15.63209 ?  9   PRO   A C   1 
ATOM   69   O O   . PRO   A 1 9   ? 2.86775   28.38106 -35.17812 1.000 15.80606 ?  9   PRO   A O   1 
ATOM   70   C CB  . PRO   A 1 9   ? 4.60887   30.93528 -35.07274 1.000 17.20979 ?  9   PRO   A CB  1 
ATOM   71   C CG  . PRO   A 1 9   ? 5.90887   30.62308 -34.33894 1.000 19.85657 ?  9   PRO   A CG  1 
ATOM   72   C CD  . PRO   A 1 9   ? 5.62280   29.52862 -33.36940 1.000 17.26355 ?  9   PRO   A CD  1 
ATOM   73   N N   . SER   A 1 10  ? 1.30646   30.01318 -35.11572 1.000 14.25794 ?  10  SER   A N   1 
ATOM   74   C CA  . SER   A 1 10  ? 0.18921   29.16186 -35.51325 1.000 18.20487 ?  10  SER   A CA  1 
ATOM   75   C C   . SER   A 1 10  ? -0.12895  29.18867 -37.00981 1.000 16.90770 ?  10  SER   A C   1 
ATOM   76   O O   . SER   A 1 10  ? -1.00539  28.43503 -37.44345 1.000 18.17112 ?  10  SER   A O   1 
ATOM   77   C CB  . SER   A 1 10  ? -1.07731  29.54943 -34.74022 1.000 16.17357 ?  10  SER   A CB  1 
ATOM   78   O OG  . SER   A 1 10  ? -1.44244  30.91761 -34.96915 1.000 16.95346 ?  10  SER   A OG  1 
ATOM   79   N N   . GLY   A 1 11  ? 0.56091   30.00402 -37.81652 1.000 18.64591 ?  11  GLY   A N   1 
ATOM   80   C CA  . GLY   A 1 11  ? 0.10548   30.22787 -39.19556 1.000 16.65560 ?  11  GLY   A CA  1 
ATOM   81   C C   . GLY   A 1 11  ? 0.08936   28.96471 -40.04505 1.000 17.39116 ?  11  GLY   A C   1 
ATOM   82   O O   . GLY   A 1 11  ? -0.82296  28.74134 -40.86278 1.000 19.27074 ?  11  GLY   A O   1 
ATOM   83   N N   . LYS   A 1 12  ? 1.10105   28.12472 -39.86791 1.000 15.11637 ?  12  LYS   A N   1 
ATOM   84   C CA  . LYS   A 1 12  ? 1.13054   26.84989 -40.57027 1.000 15.28154 ?  12  LYS   A CA  1 
ATOM   85   C C   . LYS   A 1 12  ? -0.13744  26.05019 -40.30071 1.000 18.02597 ?  12  LYS   A C   1 
ATOM   86   O O   . LYS   A 1 12  ? -0.69659  25.43668 -41.21456 1.000 21.10367 ?  12  LYS   A O   1 
ATOM   87   C CB  . LYS   A 1 12  ? 2.37399   26.05525 -40.15982 1.000 21.15690 ?  12  LYS   A CB  1 
ATOM   88   C CG  . LYS   A 1 12  ? 3.63213   26.37401 -40.95632 1.000 21.84205 ?  12  LYS   A CG  1 
ATOM   89   C CD  . LYS   A 1 12  ? 4.87621   25.99366 -40.15405 1.000 27.54790 ?  12  LYS   A CD  1 
ATOM   90   C CE  . LYS   A 1 12  ? 6.12242   25.80365 -41.03147 1.000 30.90712 ?  12  LYS   A CE  1 
ATOM   91   N NZ  . LYS   A 1 12  ? 6.13562   26.66920 -42.23502 1.000 34.65786 ?  12  LYS   A NZ  1 
ATOM   92   N N   . VAL   A 1 13  ? -0.61095  26.04063 -39.05440 1.000 15.75987 ?  13  VAL   A N   1 
ATOM   93   C CA  . VAL   A 1 13  ? -1.83816  25.29220 -38.77510 1.000 14.99132 ?  13  VAL   A CA  1 
ATOM   94   C C   . VAL   A 1 13  ? -3.08886  26.06689 -39.20032 1.000 15.42022 ?  13  VAL   A C   1 
ATOM   95   O O   . VAL   A 1 13  ? -4.08540  25.45352 -39.60075 1.000 17.89310 ?  13  VAL   A O   1 
ATOM   96   C CB  . VAL   A 1 13  ? -1.89836  24.90908 -37.28860 1.000 18.01348 ?  13  VAL   A CB  1 
ATOM   97   C CG1 . VAL   A 1 13  ? -3.17558  24.11320 -36.97573 1.000 16.32299 ?  13  VAL   A CG1 1 
ATOM   98   C CG2 . VAL   A 1 13  ? -0.65478  24.11197 -36.88883 1.000 14.86131 ?  13  VAL   A CG2 1 
ATOM   99   N N   . GLU   A 1 14  ? -3.07584  27.41047 -39.12392 1.000 13.09030 ?  14  GLU   A N   1 
ATOM   100  C CA  . GLU   A 1 14  ? -4.24004  28.17649 -39.55849 1.000 18.35695 ?  14  GLU   A CA  1 
ATOM   101  C C   . GLU   A 1 14  ? -4.57267  27.87220 -41.01115 1.000 19.38979 ?  14  GLU   A C   1 
ATOM   102  O O   . GLU   A 1 14  ? -5.75441  27.77838 -41.38392 1.000 16.40786 ?  14  GLU   A O   1 
ATOM   103  C CB  . GLU   A 1 14  ? -4.01238  29.68138 -39.40501 1.000 17.43163 ?  14  GLU   A CB  1 
ATOM   104  C CG  . GLU   A 1 14  ? -3.65469  30.15256 -37.99707 1.000 22.63105 ?  14  GLU   A CG  1 
ATOM   105  C CD  . GLU   A 1 14  ? -3.21573  31.60964 -37.97193 1.000 23.78088 ?  14  GLU   A CD  1 
ATOM   106  O OE1 . GLU   A 1 14  ? -3.80449  32.41146 -38.74272 1.000 24.91841 ?  14  GLU   A OE1 1 
ATOM   107  O OE2 . GLU   A 1 14  ? -2.29270  31.95213 -37.18808 1.000 17.81182 -1 14  GLU   A OE2 1 
ATOM   108  N N   . GLY   A 1 15  ? -3.53797  27.73761 -41.85399 1.000 16.61825 ?  15  GLY   A N   1 
ATOM   109  C CA  . GLY   A 1 15  ? -3.78872  27.41100 -43.25471 1.000 19.16701 ?  15  GLY   A CA  1 
ATOM   110  C C   . GLY   A 1 15  ? -4.35871  26.02893 -43.50946 1.000 19.20526 ?  15  GLY   A C   1 
ATOM   111  O O   . GLY   A 1 15  ? -4.65601  25.71643 -44.66485 1.000 18.64769 ?  15  GLY   A O   1 
ATOM   112  N N   . CYS   A 1 16  ? -4.52599  25.19760 -42.46912 1.000 20.50019 ?  16  CYS   A N   1 
ATOM   113  C CA  . CYS   A 1 16  ? -5.11326  23.87440 -42.61715 1.000 17.21469 ?  16  CYS   A CA  1 
ATOM   114  C C   . CYS   A 1 16  ? -6.51671  23.74404 -42.04364 1.000 18.44447 ?  16  CYS   A C   1 
ATOM   115  O O   . CYS   A 1 16  ? -7.10049  22.65498 -42.13448 1.000 18.46999 ?  16  CYS   A O   1 
ATOM   116  C CB  . CYS   A 1 16  ? -4.22631  22.81808 -41.94966 1.000 14.83519 ?  16  CYS   A CB  1 
ATOM   117  S SG  . CYS   A 1 16  ? -2.49640  22.74776 -42.49950 1.000 22.41934 ?  16  CYS   A SG  1 
ATOM   118  N N   . MET   A 1 17  ? -7.06246  24.78279 -41.42057 1.000 16.23372 ?  17  MET   A N   1 
ATOM   119  C CA  . MET   A 1 17  ? -8.33305  24.62016 -40.72801 1.000 16.78666 ?  17  MET   A CA  1 
ATOM   120  C C   . MET   A 1 17  ? -9.48902  24.81446 -41.70787 1.000 17.32652 ?  17  MET   A C   1 
ATOM   121  O O   . MET   A 1 17  ? -9.48946  25.75802 -42.50232 1.000 17.13464 ?  17  MET   A O   1 
ATOM   122  C CB  . MET   A 1 17  ? -8.44692  25.60184 -39.55625 1.000 14.54596 ?  17  MET   A CB  1 
ATOM   123  C CG  . MET   A 1 17  ? -7.40619  25.43433 -38.47134 1.000 14.83634 ?  17  MET   A CG  1 
ATOM   124  S SD  . MET   A 1 17  ? -7.25445  23.71833 -37.85467 1.000 19.37646 ?  17  MET   A SD  1 
ATOM   125  C CE  . MET   A 1 17  ? -8.91283  23.36534 -37.29010 1.000 16.52020 ?  17  MET   A CE  1 
ATOM   126  N N   . VAL   A 1 18  ? -10.47920 23.92200 -41.64469 1.000 14.71788 ?  18  VAL   A N   1 
ATOM   127  C CA  . VAL   A 1 18  ? -11.71554 24.05415 -42.41027 1.000 16.28708 ?  18  VAL   A CA  1 
ATOM   128  C C   . VAL   A 1 18  ? -12.90172 23.83028 -41.47760 1.000 18.19458 ?  18  VAL   A C   1 
ATOM   129  O O   . VAL   A 1 18  ? -12.75302 23.37945 -40.34274 1.000 18.55401 ?  18  VAL   A O   1 
ATOM   130  C CB  . VAL   A 1 18  ? -11.77367 23.07447 -43.59754 1.000 15.73752 ?  18  VAL   A CB  1 
ATOM   131  C CG1 . VAL   A 1 18  ? -10.56551 23.30890 -44.52854 1.000 17.19246 ?  18  VAL   A CG1 1 
ATOM   132  C CG2 . VAL   A 1 18  ? -11.77635 21.63005 -43.10121 1.000 12.89264 ?  18  VAL   A CG2 1 
ATOM   133  N N   . GLN   A 1 19  ? -14.08625 24.17638 -41.97016 1.000 16.64655 ?  19  GLN   A N   1 
ATOM   134  C CA  . GLN   A 1 19  ? -15.35299 23.90602 -41.30609 1.000 20.34966 ?  19  GLN   A CA  1 
ATOM   135  C C   . GLN   A 1 19  ? -15.96025 22.62505 -41.87184 1.000 20.67747 ?  19  GLN   A C   1 
ATOM   136  O O   . GLN   A 1 19  ? -16.00898 22.44948 -43.09356 1.000 21.42644 ?  19  GLN   A O   1 
ATOM   137  C CB  . GLN   A 1 19  ? -16.28659 25.09076 -41.53680 1.000 21.07311 ?  19  GLN   A CB  1 
ATOM   138  C CG  . GLN   A 1 19  ? -17.60382 25.05992 -40.83316 1.000 26.37546 ?  19  GLN   A CG  1 
ATOM   139  C CD  . GLN   A 1 19  ? -18.34044 26.37330 -41.02836 1.000 29.03961 ?  19  GLN   A CD  1 
ATOM   140  O OE1 . GLN   A 1 19  ? -19.28278 26.68627 -40.31245 1.000 32.82839 ?  19  GLN   A OE1 1 
ATOM   141  N NE2 . GLN   A 1 19  ? -17.88748 27.15919 -42.00299 1.000 30.89687 ?  19  GLN   A NE2 1 
ATOM   142  N N   . VAL   A 1 20  ? -16.44655 21.74498 -41.00290 1.000 19.93616 ?  20  VAL   A N   1 
ATOM   143  C CA  . VAL   A 1 20  ? -17.07987 20.50084 -41.42720 1.000 18.09405 ?  20  VAL   A CA  1 
ATOM   144  C C   . VAL   A 1 20  ? -18.49037 20.47643 -40.85594 1.000 26.93438 ?  20  VAL   A C   1 
ATOM   145  O O   . VAL   A 1 20  ? -18.68189 20.56497 -39.63463 1.000 22.43724 ?  20  VAL   A O   1 
ATOM   146  C CB  . VAL   A 1 20  ? -16.28058 19.27051 -40.97805 1.000 22.75988 ?  20  VAL   A CB  1 
ATOM   147  C CG1 . VAL   A 1 20  ? -16.97633 17.99509 -41.43769 1.000 16.91472 ?  20  VAL   A CG1 1 
ATOM   148  C CG2 . VAL   A 1 20  ? -14.86502 19.33956 -41.52894 1.000 16.19266 ?  20  VAL   A CG2 1 
ATOM   149  N N   . THR   A 1 21  ? -19.47664 20.35657 -41.73407 1.000 22.19707 ?  21  THR   A N   1 
ATOM   150  C CA  . THR   A 1 21  ? -20.87564 20.38594 -41.34096 1.000 24.43815 ?  21  THR   A CA  1 
ATOM   151  C C   . THR   A 1 21  ? -21.53178 19.11962 -41.86602 1.000 28.38128 ?  21  THR   A C   1 
ATOM   152  O O   . THR   A 1 21  ? -21.39937 18.78989 -43.04525 1.000 25.28528 ?  21  THR   A O   1 
ATOM   153  C CB  . THR   A 1 21  ? -21.58430 21.62359 -41.90559 1.000 22.13210 ?  21  THR   A CB  1 
ATOM   154  O OG1 . THR   A 1 21  ? -21.03609 22.80794 -41.32953 1.000 24.36505 ?  21  THR   A OG1 1 
ATOM   155  C CG2 . THR   A 1 21  ? -23.07393 21.58821 -41.60528 1.000 32.70124 ?  21  THR   A CG2 1 
ATOM   156  N N   . CYS   A 1 22  ? -22.21146 18.40141 -40.98801 1.000 25.04759 ?  22  CYS   A N   1 
ATOM   157  C CA  . CYS   A 1 22  ? -23.01084 17.24474 -41.36675 1.000 26.70920 ?  22  CYS   A CA  1 
ATOM   158  C C   . CYS   A 1 22  ? -24.39092 17.49422 -40.77295 1.000 32.57761 ?  22  CYS   A C   1 
ATOM   159  O O   . CYS   A 1 22  ? -24.52588 17.63589 -39.55099 1.000 28.86059 ?  22  CYS   A O   1 
ATOM   160  C CB  . CYS   A 1 22  ? -22.37791 15.94762 -40.85403 1.000 26.77818 ?  22  CYS   A CB  1 
ATOM   161  S SG  . CYS   A 1 22  ? -23.13213 14.41764 -41.45664 1.000 40.33640 ?  22  CYS   A SG  1 
ATOM   162  N N   . GLY   A 1 23  ? -25.39515 17.62381 -41.64113 1.000 31.79120 ?  23  GLY   A N   1 
ATOM   163  C CA  . GLY   A 1 23  ? -26.74114 17.95418 -41.21165 1.000 32.95752 ?  23  GLY   A CA  1 
ATOM   164  C C   . GLY   A 1 23  ? -26.81082 19.26172 -40.45035 1.000 32.44230 ?  23  GLY   A C   1 
ATOM   165  O O   . GLY   A 1 23  ? -26.62158 20.33512 -41.02253 1.000 43.13026 ?  23  GLY   A O   1 
ATOM   166  N N   . THR   A 1 24  ? -27.05236 19.18313 -39.14714 1.000 32.72817 ?  24  THR   A N   1 
ATOM   167  C CA  . THR   A 1 24  ? -27.14520 20.35944 -38.29639 1.000 40.07665 ?  24  THR   A CA  1 
ATOM   168  C C   . THR   A 1 24  ? -25.91515 20.57177 -37.42008 1.000 38.86669 ?  24  THR   A C   1 
ATOM   169  O O   . THR   A 1 24  ? -25.84745 21.58342 -36.70835 1.000 41.33694 ?  24  THR   A O   1 
ATOM   170  C CB  . THR   A 1 24  ? -28.38843 20.25339 -37.39733 1.000 42.16669 ?  24  THR   A CB  1 
ATOM   171  O OG1 . THR   A 1 24  ? -28.61527 21.49767 -36.72218 1.000 50.06162 ?  24  THR   A OG1 1 
ATOM   172  C CG2 . THR   A 1 24  ? -28.19421 19.14760 -36.36379 1.000 45.29474 ?  24  THR   A CG2 1 
ATOM   173  N N   . THR   A 1 25  ? -24.95346 19.65233 -37.44499 1.000 31.60882 ?  25  THR   A N   1 
ATOM   174  C CA  . THR   A 1 25  ? -23.76927 19.73191 -36.59808 1.000 31.18199 ?  25  THR   A CA  1 
ATOM   175  C C   . THR   A 1 25  ? -22.60122 20.30317 -37.38553 1.000 27.53937 ?  25  THR   A C   1 
ATOM   176  O O   . THR   A 1 25  ? -22.33413 19.87050 -38.50687 1.000 26.97324 ?  25  THR   A O   1 
ATOM   177  C CB  . THR   A 1 25  ? -23.39555 18.35375 -36.06219 1.000 32.33343 ?  25  THR   A CB  1 
ATOM   178  O OG1 . THR   A 1 25  ? -24.53743 17.78539 -35.42418 1.000 37.60667 ?  25  THR   A OG1 1 
ATOM   179  C CG2 . THR   A 1 25  ? -22.25247 18.46575 -35.06324 1.000 25.19722 ?  25  THR   A CG2 1 
ATOM   180  N N   . THR   A 1 26  ? -21.90147 21.26141 -36.79768 1.000 27.84864 ?  26  THR   A N   1 
ATOM   181  C CA  . THR   A 1 26  ? -20.73295 21.85077 -37.42818 1.000 23.44159 ?  26  THR   A CA  1 
ATOM   182  C C   . THR   A 1 26  ? -19.57898 21.83779 -36.43926 1.000 25.18800 ?  26  THR   A C   1 
ATOM   183  O O   . THR   A 1 26  ? -19.76372 22.16035 -35.26507 1.000 22.13363 ?  26  THR   A O   1 
ATOM   184  C CB  . THR   A 1 26  ? -21.03450 23.27411 -37.88952 1.000 27.77731 ?  26  THR   A CB  1 
ATOM   185  O OG1 . THR   A 1 26  ? -21.93844 23.21684 -38.99769 1.000 33.35450 ?  26  THR   A OG1 1 
ATOM   186  C CG2 . THR   A 1 26  ? -19.77200 23.96859 -38.34264 1.000 25.38278 ?  26  THR   A CG2 1 
ATOM   187  N N   . LEU   A 1 27  ? -18.39799 21.44420 -36.89766 1.000 21.12545 ?  27  LEU   A N   1 
ATOM   188  C CA  . LEU   A 1 27  ? -17.21317 21.57499 -36.05974 1.000 20.42113 ?  27  LEU   A CA  1 
ATOM   189  C C   . LEU   A 1 27  ? -16.03155 21.81089 -36.99290 1.000 21.52332 ?  27  LEU   A C   1 
ATOM   190  O O   . LEU   A 1 27  ? -16.21655 22.10521 -38.17365 1.000 16.53625 ?  27  LEU   A O   1 
ATOM   191  C CB  . LEU   A 1 27  ? -17.06806 20.36219 -35.13022 1.000 20.15946 ?  27  LEU   A CB  1 
ATOM   192  C CG  . LEU   A 1 27  ? -17.34565 18.94773 -35.64562 1.000 22.65757 ?  27  LEU   A CG  1 
ATOM   193  C CD1 . LEU   A 1 27  ? -16.32227 18.59140 -36.70594 1.000 24.94899 ?  27  LEU   A CD1 1 
ATOM   194  C CD2 . LEU   A 1 27  ? -17.32183 17.92250 -34.49478 1.000 20.82527 ?  27  LEU   A CD2 1 
ATOM   195  N N   . ASN   A 1 28  ? -14.81255 21.68855 -36.47329 1.000 18.34890 ?  28  ASN   A N   1 
ATOM   196  C CA  . ASN   A 1 28  ? -13.62253 22.02621 -37.24721 1.000 18.31699 ?  28  ASN   A CA  1 
ATOM   197  C C   . ASN   A 1 28  ? -12.97346 20.78220 -37.83606 1.000 15.37164 ?  28  ASN   A C   1 
ATOM   198  O O   . ASN   A 1 28  ? -13.07382 19.68808 -37.28631 1.000 15.87490 ?  28  ASN   A O   1 
ATOM   199  C CB  . ASN   A 1 28  ? -12.59757 22.74588 -36.37483 1.000 16.43616 ?  28  ASN   A CB  1 
ATOM   200  C CG  . ASN   A 1 28  ? -13.14702 24.00149 -35.75219 1.000 19.99114 ?  28  ASN   A CG  1 
ATOM   201  O OD1 . ASN   A 1 28  ? -13.28472 25.02621 -36.42520 1.000 19.14423 ?  28  ASN   A OD1 1 
ATOM   202  N ND2 . ASN   A 1 28  ? -13.44620 23.94343 -34.44916 1.000 16.41226 ?  28  ASN   A ND2 1 
ATOM   203  N N   . GLY   A 1 29  ? -12.25099 20.96687 -38.93510 1.000 15.98767 ?  29  GLY   A N   1 
ATOM   204  C CA  . GLY   A 1 29  ? -11.49775 19.89149 -39.52882 1.000 13.67708 ?  29  GLY   A CA  1 
ATOM   205  C C   . GLY   A 1 29  ? -10.11908 20.37539 -39.92147 1.000 14.74838 ?  29  GLY   A C   1 
ATOM   206  O O   . GLY   A 1 29  ? -9.87836  21.57066 -40.09033 1.000 17.46977 ?  29  GLY   A O   1 
ATOM   207  N N   . LEU   A 1 30  ? -9.21424  19.41325 -40.05708 1.000 15.63040 ?  30  LEU   A N   1 
ATOM   208  C CA  . LEU   A 1 30  ? -7.81365  19.64907 -40.40290 1.000 18.29909 ?  30  LEU   A CA  1 
ATOM   209  C C   . LEU   A 1 30  ? -7.59520  19.15869 -41.83070 1.000 17.01172 ?  30  LEU   A C   1 
ATOM   210  O O   . LEU   A 1 30  ? -7.75521  17.96711 -42.11208 1.000 15.37609 ?  30  LEU   A O   1 
ATOM   211  C CB  . LEU   A 1 30  ? -6.88593  18.91449 -39.42883 1.000 14.06677 ?  30  LEU   A CB  1 
ATOM   212  C CG  . LEU   A 1 30  ? -5.36860  19.15196 -39.53216 1.000 13.82290 ?  30  LEU   A CG  1 
ATOM   213  C CD1 . LEU   A 1 30  ? -5.01838  20.53329 -39.04165 1.000 12.42039 ?  30  LEU   A CD1 1 
ATOM   214  C CD2 . LEU   A 1 30  ? -4.61792  18.12047 -38.74476 1.000 17.14420 ?  30  LEU   A CD2 1 
ATOM   215  N N   . TRP   A 1 31  ? -7.27232  20.07025 -42.72654 1.000 16.52199 ?  31  TRP   A N   1 
ATOM   216  C CA  . TRP   A 1 31  ? -7.18017  19.78040 -44.15268 1.000 15.77778 ?  31  TRP   A CA  1 
ATOM   217  C C   . TRP   A 1 31  ? -5.70240  19.64414 -44.51953 1.000 18.38831 ?  31  TRP   A C   1 
ATOM   218  O O   . TRP   A 1 31  ? -4.97184  20.63668 -44.59155 1.000 17.76502 ?  31  TRP   A O   1 
ATOM   219  C CB  . TRP   A 1 31  ? -7.87072  20.88326 -44.94456 1.000 17.80574 ?  31  TRP   A CB  1 
ATOM   220  C CG  . TRP   A 1 31  ? -7.86269  20.68867 -46.43227 1.000 16.26305 ?  31  TRP   A CG  1 
ATOM   221  C CD1 . TRP   A 1 31  ? -7.76420  19.51051 -47.10964 1.000 19.84266 ?  31  TRP   A CD1 1 
ATOM   222  C CD2 . TRP   A 1 31  ? -7.96735  21.71551 -47.41708 1.000 16.81554 ?  31  TRP   A CD2 1 
ATOM   223  N NE1 . TRP   A 1 31  ? -7.80004  19.74413 -48.46672 1.000 19.08816 ?  31  TRP   A NE1 1 
ATOM   224  C CE2 . TRP   A 1 31  ? -7.92207  21.09098 -48.68014 1.000 17.62376 ?  31  TRP   A CE2 1 
ATOM   225  C CE3 . TRP   A 1 31  ? -8.09345  23.10909 -47.35225 1.000 15.94134 ?  31  TRP   A CE3 1 
ATOM   226  C CZ2 . TRP   A 1 31  ? -8.00054  21.80735 -49.86969 1.000 20.89367 ?  31  TRP   A CZ2 1 
ATOM   227  C CZ3 . TRP   A 1 31  ? -8.16943  23.81916 -48.52370 1.000 23.83258 ?  31  TRP   A CZ3 1 
ATOM   228  C CH2 . TRP   A 1 31  ? -8.12187  23.16547 -49.77723 1.000 20.91345 ?  31  TRP   A CH2 1 
ATOM   229  N N   . LEU   A 1 32  ? -5.26854  18.40816 -44.77062 1.000 19.63784 ?  32  LEU   A N   1 
ATOM   230  C CA  . LEU   A 1 32  ? -3.88612  18.10325 -45.12082 1.000 21.67132 ?  32  LEU   A CA  1 
ATOM   231  C C   . LEU   A 1 32  ? -3.88186  17.29533 -46.41419 1.000 22.46327 ?  32  LEU   A C   1 
ATOM   232  O O   . LEU   A 1 32  ? -4.52525  16.24019 -46.49296 1.000 21.56570 ?  32  LEU   A O   1 
ATOM   233  C CB  . LEU   A 1 32  ? -3.19761  17.32235 -44.00029 1.000 16.38210 ?  32  LEU   A CB  1 
ATOM   234  C CG  . LEU   A 1 32  ? -3.13659  18.01123 -42.63616 1.000 20.24722 ?  32  LEU   A CG  1 
ATOM   235  C CD1 . LEU   A 1 32  ? -2.67902  17.03215 -41.55922 1.000 15.05660 ?  32  LEU   A CD1 1 
ATOM   236  C CD2 . LEU   A 1 32  ? -2.20159  19.19889 -42.73125 1.000 15.28955 ?  32  LEU   A CD2 1 
ATOM   237  N N   . ASP   A 1 33  ? -3.15535  17.78677 -47.41689 1.000 21.63385 ?  33  ASP   A N   1 
ATOM   238  C CA  . ASP   A 1 33  ? -3.17092  17.17452 -48.75135 1.000 24.22678 ?  33  ASP   A CA  1 
ATOM   239  C C   . ASP   A 1 33  ? -4.60119  17.12479 -49.17971 1.000 21.29860 ?  33  ASP   A C   1 
ATOM   240  O O   . ASP   A 1 33  ? -5.28642  18.18976 -49.15317 1.000 21.02936 ?  33  ASP   A O   1 
ATOM   241  C CB  . ASP   A 1 33  ? -2.43602  15.82496 -48.71734 1.000 18.36713 ?  33  ASP   A CB  1 
ATOM   242  C CG  . ASP   A 1 33  ? -0.92370  15.97589 -48.46508 1.000 23.58147 ?  33  ASP   A CG  1 
ATOM   243  O OD1 . ASP   A 1 33  ? -0.34117  16.98452 -48.88511 1.000 23.39092 ?  33  ASP   A OD1 1 
ATOM   244  O OD2 . ASP   A 1 33  ? -0.30761  15.08146 -47.85799 1.000 28.38625 -1 33  ASP   A OD2 1 
ATOM   245  N N   . ASP   A 1 34  ? -5.16892  15.99410 -49.58313 1.000 19.72269 ?  34  ASP   A N   1 
ATOM   246  C CA  . ASP   A 1 34  ? -6.54656  15.91667 -50.03202 1.000 25.32117 ?  34  ASP   A CA  1 
ATOM   247  C C   . ASP   A 1 34  ? -7.41230  15.18812 -49.01096 1.000 22.95804 ?  34  ASP   A C   1 
ATOM   248  O O   . ASP   A 1 34  ? -8.35370  14.48899 -49.37898 1.000 25.42414 ?  34  ASP   A O   1 
ATOM   249  C CB  . ASP   A 1 34  ? -6.65020  15.25117 -51.41003 1.000 25.94963 ?  34  ASP   A CB  1 
ATOM   250  C CG  . ASP   A 1 34  ? -6.23232  13.76290 -51.39508 1.000 33.17977 ?  34  ASP   A CG  1 
ATOM   251  O OD1 . ASP   A 1 34  ? -5.54985  13.32745 -50.44281 1.000 31.42596 ?  34  ASP   A OD1 1 
ATOM   252  O OD2 . ASP   A 1 34  ? -6.60177  13.02319 -52.33249 1.000 40.58875 -1 34  ASP   A OD2 1 
ATOM   253  N N   . VAL   A 1 35  ? -7.07482  15.29585 -47.72298 1.000 21.73284 ?  35  VAL   A N   1 
ATOM   254  C CA  . VAL   A 1 35  ? -7.83675  14.61067 -46.68512 1.000 22.48130 ?  35  VAL   A CA  1 
ATOM   255  C C   . VAL   A 1 35  ? -8.18625  15.61491 -45.58794 1.000 22.38702 ?  35  VAL   A C   1 
ATOM   256  O O   . VAL   A 1 35  ? -7.34272  16.41583 -45.17677 1.000 18.98874 ?  35  VAL   A O   1 
ATOM   257  C CB  . VAL   A 1 35  ? -7.05828  13.41008 -46.11982 1.000 20.52870 ?  35  VAL   A CB  1 
ATOM   258  C CG1 . VAL   A 1 35  ? -7.84267  12.69899 -45.00341 1.000 20.40579 ?  35  VAL   A CG1 1 
ATOM   259  C CG2 . VAL   A 1 35  ? -6.72582  12.42456 -47.24259 1.000 22.95233 ?  35  VAL   A CG2 1 
ATOM   260  N N   . VAL   A 1 36  ? -9.43806  15.59307 -45.14197 1.000 20.56518 ?  36  VAL   A N   1 
ATOM   261  C CA  . VAL   A 1 36  ? -9.89355  16.38831 -44.01627 1.000 17.98007 ?  36  VAL   A CA  1 
ATOM   262  C C   . VAL   A 1 36  ? -10.11501 15.42785 -42.86538 1.000 20.82649 ?  36  VAL   A C   1 
ATOM   263  O O   . VAL   A 1 36  ? -10.80714 14.42107 -43.02425 1.000 22.17893 ?  36  VAL   A O   1 
ATOM   264  C CB  . VAL   A 1 36  ? -11.17736 17.17067 -44.34781 1.000 19.48431 ?  36  VAL   A CB  1 
ATOM   265  C CG1 . VAL   A 1 36  ? -11.63119 17.95775 -43.12615 1.000 15.39737 ?  36  VAL   A CG1 1 
ATOM   266  C CG2 . VAL   A 1 36  ? -10.96090 18.09909 -45.54092 1.000 17.28404 ?  36  VAL   A CG2 1 
ATOM   267  N N   . TYR   A 1 37  ? -9.49265  15.71289 -41.72990 1.000 18.41482 ?  37  TYR   A N   1 
ATOM   268  C CA  . TYR   A 1 37  ? -9.61367  14.91414 -40.52119 1.000 15.87664 ?  37  TYR   A CA  1 
ATOM   269  C C   . TYR   A 1 37  ? -10.50409 15.67011 -39.54558 1.000 18.40514 ?  37  TYR   A C   1 
ATOM   270  O O   . TYR   A 1 37  ? -10.28783 16.86445 -39.31790 1.000 19.53530 ?  37  TYR   A O   1 
ATOM   271  C CB  . TYR   A 1 37  ? -8.23563  14.67013 -39.90160 1.000 18.36672 ?  37  TYR   A CB  1 
ATOM   272  C CG  . TYR   A 1 37  ? -7.21606  14.02323 -40.83208 1.000 20.59212 ?  37  TYR   A CG  1 
ATOM   273  C CD1 . TYR   A 1 37  ? -6.54711  14.78134 -41.79901 1.000 20.59005 ?  37  TYR   A CD1 1 
ATOM   274  C CD2 . TYR   A 1 37  ? -6.91243  12.65488 -40.73312 1.000 19.93626 ?  37  TYR   A CD2 1 
ATOM   275  C CE1 . TYR   A 1 37  ? -5.60963  14.19569 -42.64999 1.000 22.22648 ?  37  TYR   A CE1 1 
ATOM   276  C CE2 . TYR   A 1 37  ? -5.97135  12.05962 -41.57956 1.000 21.56592 ?  37  TYR   A CE2 1 
ATOM   277  C CZ  . TYR   A 1 37  ? -5.33507  12.83085 -42.53288 1.000 25.63910 ?  37  TYR   A CZ  1 
ATOM   278  O OH  . TYR   A 1 37  ? -4.41144  12.25017 -43.37136 1.000 30.05427 ?  37  TYR   A OH  1 
ATOM   279  N N   . CYS   A 1 38  ? -11.50529 15.01208 -38.96752 1.000 17.01739 ?  38  CYS   A N   1 
ATOM   280  C CA  . CYS   A 1 38  ? -12.32712 15.71864 -38.00226 1.000 17.64890 ?  38  CYS   A CA  1 
ATOM   281  C C   . CYS   A 1 38  ? -12.93259 14.73699 -37.02231 1.000 21.45099 ?  38  CYS   A C   1 
ATOM   282  O O   . CYS   A 1 38  ? -12.89355 13.52168 -37.26850 1.000 22.54618 ?  38  CYS   A O   1 
ATOM   283  C CB  . CYS   A 1 38  ? -13.41534 16.54599 -38.70619 1.000 19.35237 ?  38  CYS   A CB  1 
ATOM   284  S SG  . CYS   A 1 38  ? -14.73384 15.54322 -39.41476 1.000 22.37487 ?  38  CYS   A SG  1 
ATOM   285  N N   . PRO   A 1 39  ? -13.45168 15.16450 -35.87719 1.000 20.49939 ?  39  PRO   A N   1 
ATOM   286  C CA  . PRO   A 1 39  ? -14.02688 14.22523 -34.91919 1.000 18.17927 ?  39  PRO   A CA  1 
ATOM   287  C C   . PRO   A 1 39  ? -15.25294 13.53232 -35.51078 1.000 18.51823 ?  39  PRO   A C   1 
ATOM   288  O O   . PRO   A 1 39  ? -16.02104 14.13676 -36.24817 1.000 16.96719 ?  39  PRO   A O   1 
ATOM   289  C CB  . PRO   A 1 39  ? -14.41108 15.09874 -33.72410 1.000 19.09116 ?  39  PRO   A CB  1 
ATOM   290  C CG  . PRO   A 1 39  ? -13.50097 16.31626 -33.85902 1.000 21.71310 ?  39  PRO   A CG  1 
ATOM   291  C CD  . PRO   A 1 39  ? -13.43311 16.54436 -35.32893 1.000 17.79568 ?  39  PRO   A CD  1 
ATOM   292  N N   . ARG   A 1 40  ? -15.43809 12.25820 -35.17989 1.000 19.14914 ?  40  ARG   A N   1 
ATOM   293  C CA  . ARG   A 1 40  ? -16.52885 11.49859 -35.80566 1.000 22.04785 ?  40  ARG   A CA  1 
ATOM   294  C C   . ARG   A 1 40  ? -17.90596 11.91902 -35.28045 1.000 21.79959 ?  40  ARG   A C   1 
ATOM   295  O O   . ARG   A 1 40  ? -18.91575 11.75546 -35.98949 1.000 22.98077 ?  40  ARG   A O   1 
ATOM   296  C CB  . ARG   A 1 40  ? -16.30323 9.97608  -35.62960 1.000 19.95070 ?  40  ARG   A CB  1 
ATOM   297  C CG  . ARG   A 1 40  ? -16.31592 9.48641  -34.18507 1.000 18.20739 ?  40  ARG   A CG  1 
ATOM   298  C CD  . ARG   A 1 40  ? -16.20986 7.94788  -34.04321 1.000 16.86440 ?  40  ARG   A CD  1 
ATOM   299  N NE  . ARG   A 1 40  ? -16.23475 7.57030  -32.63240 1.000 18.05093 ?  40  ARG   A NE  1 
ATOM   300  C CZ  . ARG   A 1 40  ? -16.20157 6.32957  -32.15570 1.000 24.15319 ?  40  ARG   A CZ  1 
ATOM   301  N NH1 . ARG   A 1 40  ? -16.09229 5.28450  -32.94821 1.000 25.08710 ?  40  ARG   A NH1 1 
ATOM   302  N NH2 . ARG   A 1 40  ? -16.30874 6.13219  -30.84569 1.000 23.86203 ?  40  ARG   A NH2 1 
ATOM   303  N N   . HIS   A 1 41  ? -17.97004 12.54654 -34.10561 1.000 20.14130 ?  41  HIS   A N   1 
ATOM   304  C CA  . HIS   A 1 41  ? -19.28128 12.93506 -33.61668 1.000 21.24580 ?  41  HIS   A CA  1 
ATOM   305  C C   . HIS   A 1 41  ? -19.87532 14.09927 -34.39682 1.000 23.38290 ?  41  HIS   A C   1 
ATOM   306  O O   . HIS   A 1 41  ? -20.98551 14.52545 -34.06552 1.000 25.13819 ?  41  HIS   A O   1 
ATOM   307  C CB  . HIS   A 1 41  ? -19.25050 13.21722 -32.10867 1.000 20.05696 ?  41  HIS   A CB  1 
ATOM   308  C CG  . HIS   A 1 41  ? -18.60520 14.51524 -31.71130 1.000 22.30086 ?  41  HIS   A CG  1 
ATOM   309  N ND1 . HIS   A 1 41  ? -17.34263 14.57766 -31.15886 1.000 27.56914 ?  41  HIS   A ND1 1 
ATOM   310  C CD2 . HIS   A 1 41  ? -19.07315 15.78497 -31.71900 1.000 23.32572 ?  41  HIS   A CD2 1 
ATOM   311  C CE1 . HIS   A 1 41  ? -17.04676 15.83521 -30.87772 1.000 24.24379 ?  41  HIS   A CE1 1 
ATOM   312  N NE2 . HIS   A 1 41  ? -18.08211 16.58682 -31.20284 1.000 25.86294 ?  41  HIS   A NE2 1 
ATOM   313  N N   . VAL   A 1 42  ? -19.21785 14.58027 -35.46476 1.000 24.17275 ?  42  VAL   A N   1 
ATOM   314  C CA  . VAL   A 1 42  ? -19.91152 15.49510 -36.37859 1.000 19.29745 ?  42  VAL   A CA  1 
ATOM   315  C C   . VAL   A 1 42  ? -21.13617 14.82489 -36.99285 1.000 25.03079 ?  42  VAL   A C   1 
ATOM   316  O O   . VAL   A 1 42  ? -22.06629 15.52289 -37.42684 1.000 26.14861 ?  42  VAL   A O   1 
ATOM   317  C CB  . VAL   A 1 42  ? -18.98388 16.03747 -37.49574 1.000 22.43052 ?  42  VAL   A CB  1 
ATOM   318  C CG1 . VAL   A 1 42  ? -18.59552 14.94552 -38.48656 1.000 20.07112 ?  42  VAL   A CG1 1 
ATOM   319  C CG2 . VAL   A 1 42  ? -19.63593 17.20172 -38.25393 1.000 21.58422 ?  42  VAL   A CG2 1 
ATOM   320  N N   . ILE   A 1 43  ? -21.17793 13.48639 -37.02676 1.000 20.66957 ?  43  ILE   A N   1 
ATOM   321  C CA  . ILE   A 1 43  ? -22.32114 12.82353 -37.65342 1.000 29.54189 ?  43  ILE   A CA  1 
ATOM   322  C C   . ILE   A 1 43  ? -23.45758 12.59052 -36.65630 1.000 28.51132 ?  43  ILE   A C   1 
ATOM   323  O O   . ILE   A 1 43  ? -24.46352 11.95876 -36.98982 1.000 33.14079 ?  43  ILE   A O   1 
ATOM   324  C CB  . ILE   A 1 43  ? -21.92625 11.48575 -38.31192 1.000 23.72539 ?  43  ILE   A CB  1 
ATOM   325  C CG1 . ILE   A 1 43  ? -21.52104 10.45030 -37.25260 1.000 21.34967 ?  43  ILE   A CG1 1 
ATOM   326  C CG2 . ILE   A 1 43  ? -20.85107 11.68878 -39.37947 1.000 24.71309 ?  43  ILE   A CG2 1 
ATOM   327  C CD1 . ILE   A 1 43  ? -21.09386 9.08945  -37.88759 1.000 24.44739 ?  43  ILE   A CD1 1 
ATOM   328  N N   . CYS   A 1 44  ? -23.31051 13.07235 -35.43031 1.000 27.11156 ?  44  CYS   A N   1 
ATOM   329  C CA  . CYS   A 1 44  ? -24.35017 12.93487 -34.41973 1.000 33.11283 ?  44  CYS   A CA  1 
ATOM   330  C C   . CYS   A 1 44  ? -25.30773 14.11613 -34.42667 1.000 34.36653 ?  44  CYS   A C   1 
ATOM   331  O O   . CYS   A 1 44  ? -24.90747 15.26000 -34.66490 1.000 35.43840 ?  44  CYS   A O   1 
ATOM   332  C CB  . CYS   A 1 44  ? -23.74985 12.81688 -33.02805 1.000 31.12608 ?  44  CYS   A CB  1 
ATOM   333  S SG  . CYS   A 1 44  ? -22.95835 11.28202 -32.75109 1.000 37.18506 ?  44  CYS   A SG  1 
ATOM   334  N N   . THR   A 1 45  ? -26.57341 13.82683 -34.14916 1.000 31.31055 ?  45  THR   A N   1 
ATOM   335  C CA  . THR   A 1 45  ? -27.51466 14.84947 -33.73172 1.000 40.09909 ?  45  THR   A CA  1 
ATOM   336  C C   . THR   A 1 45  ? -27.36417 15.06403 -32.22621 1.000 43.74771 ?  45  THR   A C   1 
ATOM   337  O O   . THR   A 1 45  ? -26.53239 14.42914 -31.56158 1.000 44.48852 ?  45  THR   A O   1 
ATOM   338  C CB  . THR   A 1 45  ? -28.94463 14.44164 -34.09842 1.000 43.73648 ?  45  THR   A CB  1 
ATOM   339  O OG1 . THR   A 1 45  ? -29.31429 13.27180 -33.35247 1.000 40.34555 ?  45  THR   A OG1 1 
ATOM   340  C CG2 . THR   A 1 45  ? -29.04601 14.13111 -35.59136 1.000 34.99088 ?  45  THR   A CG2 1 
ATOM   341  N N   . SER   A 1 46  ? -28.19136 15.95475 -31.67288 1.000 45.41719 ?  46  SER   A N   1 
ATOM   342  C CA  . SER   A 1 46  ? -28.20386 16.13760 -30.22421 1.000 51.05687 ?  46  SER   A CA  1 
ATOM   343  C C   . SER   A 1 46  ? -28.61868 14.85565 -29.50654 1.000 47.47068 ?  46  SER   A C   1 
ATOM   344  O O   . SER   A 1 46  ? -28.01252 14.47841 -28.49546 1.000 55.98964 ?  46  SER   A O   1 
ATOM   345  C CB  . SER   A 1 46  ? -29.13894 17.28522 -29.84516 1.000 56.40008 ?  46  SER   A CB  1 
ATOM   346  O OG  . SER   A 1 46  ? -28.62152 18.53046 -30.25760 1.000 57.41772 ?  46  SER   A OG  1 
ATOM   347  N N   . GLU   A 1 47  ? -29.64806 14.17121 -30.00982 1.000 44.64716 ?  47  GLU   A N   1 
ATOM   348  C CA  . GLU   A 1 47  ? -30.10725 12.96025 -29.34020 1.000 43.71740 ?  47  GLU   A CA  1 
ATOM   349  C C   . GLU   A 1 47  ? -29.08477 11.83125 -29.43770 1.000 46.95642 ?  47  GLU   A C   1 
ATOM   350  O O   . GLU   A 1 47  ? -28.95224 11.04053 -28.49447 1.000 46.51028 ?  47  GLU   A O   1 
ATOM   351  C CB  . GLU   A 1 47  ? -31.45356 12.51987 -29.91353 1.000 44.88644 ?  47  GLU   A CB  1 
ATOM   352  N N   . ASP   A 1 48  ? -28.33538 11.75004 -30.54479 1.000 40.11450 ?  48  ASP   A N   1 
ATOM   353  C CA  . ASP   A 1 48  ? -27.41044 10.62933 -30.71835 1.000 41.46118 ?  48  ASP   A CA  1 
ATOM   354  C C   . ASP   A 1 48  ? -26.28368 10.64237 -29.69675 1.000 38.75866 ?  48  ASP   A C   1 
ATOM   355  O O   . ASP   A 1 48  ? -25.70464 9.59039  -29.39900 1.000 35.82688 ?  48  ASP   A O   1 
ATOM   356  C CB  . ASP   A 1 48  ? -26.80892 10.64035 -32.12236 1.000 41.54450 ?  48  ASP   A CB  1 
ATOM   357  C CG  . ASP   A 1 48  ? -27.76999 10.13379 -33.16797 1.000 47.69298 ?  48  ASP   A CG  1 
ATOM   358  O OD1 . ASP   A 1 48  ? -28.14412 10.93393 -34.06959 1.000 51.23976 ?  48  ASP   A OD1 1 
ATOM   359  O OD2 . ASP   A 1 48  ? -28.14151 8.93227  -33.06192 1.000 50.07178 -1 48  ASP   A OD2 1 
ATOM   360  N N   . MET   A 1 49  ? -25.95279 11.81241 -29.15591 1.000 40.47675 ?  49  MET   A N   1 
ATOM   361  C CA  . MET   A 1 49  ? -24.71119 11.93450 -28.40956 1.000 40.98167 ?  49  MET   A CA  1 
ATOM   362  C C   . MET   A 1 49  ? -24.74769 11.25129 -27.05216 1.000 32.18465 ?  49  MET   A C   1 
ATOM   363  O O   . MET   A 1 49  ? -23.68570 11.04278 -26.46453 1.000 31.68349 ?  49  MET   A O   1 
ATOM   364  C CB  . MET   A 1 49  ? -24.34392 13.40678 -28.26920 1.000 40.70297 ?  49  MET   A CB  1 
ATOM   365  C CG  . MET   A 1 49  ? -23.48997 13.84965 -29.44958 1.000 41.26667 ?  49  MET   A CG  1 
ATOM   366  S SD  . MET   A 1 49  ? -23.59791 15.60011 -29.79691 1.000 64.83929 ?  49  MET   A SD  1 
ATOM   367  C CE  . MET   A 1 49  ? -24.27999 16.20363 -28.25167 1.000 49.12118 ?  49  MET   A CE  1 
ATOM   368  N N   . LEU   A 1 50  ? -25.91532 10.84000 -26.56650 1.000 32.20290 ?  50  LEU   A N   1 
ATOM   369  C CA  . LEU   A 1 50  ? -25.96895 10.18538 -25.26110 1.000 31.77555 ?  50  LEU   A CA  1 
ATOM   370  C C   . LEU   A 1 50  ? -25.34506 8.79448  -25.30618 1.000 29.76962 ?  50  LEU   A C   1 
ATOM   371  O O   . LEU   A 1 50  ? -24.68306 8.37993  -24.34771 1.000 32.14911 ?  50  LEU   A O   1 
ATOM   372  C CB  . LEU   A 1 50  ? -27.41407 10.12194 -24.75557 1.000 34.74726 ?  50  LEU   A CB  1 
ATOM   373  C CG  . LEU   A 1 50  ? -28.04014 11.42544 -24.20000 1.000 43.01184 ?  50  LEU   A CG  1 
ATOM   374  C CD1 . LEU   A 1 50  ? -27.24134 12.02453 -23.02058 1.000 29.01190 ?  50  LEU   A CD1 1 
ATOM   375  C CD2 . LEU   A 1 50  ? -28.26388 12.47873 -25.29263 1.000 36.82444 ?  50  LEU   A CD2 1 
ATOM   376  N N   . ASN   A 1 51  ? -25.53060 8.06590  -26.40827 1.000 25.79590 ?  51  ASN   A N   1 
ATOM   377  C CA  . ASN   A 1 51  ? -24.94173 6.74264  -26.59838 1.000 29.90934 ?  51  ASN   A CA  1 
ATOM   378  C C   . ASN   A 1 51  ? -24.92300 6.39948  -28.08195 1.000 32.71007 ?  51  ASN   A C   1 
ATOM   379  O O   . ASN   A 1 51  ? -25.75420 5.61301  -28.55100 1.000 30.32134 ?  51  ASN   A O   1 
ATOM   380  C CB  . ASN   A 1 51  ? -25.72435 5.67303  -25.83707 1.000 38.38280 ?  51  ASN   A CB  1 
ATOM   381  C CG  . ASN   A 1 51  ? -24.89274 4.44803  -25.55293 1.000 44.99012 ?  51  ASN   A CG  1 
ATOM   382  O OD1 . ASN   A 1 51  ? -23.65991 4.49516  -25.59287 1.000 43.34292 ?  51  ASN   A OD1 1 
ATOM   383  N ND2 . ASN   A 1 51  ? -25.55911 3.33776  -25.25741 1.000 54.89999 ?  51  ASN   A ND2 1 
ATOM   384  N N   . PRO   A 1 52  ? -24.01321 6.98178  -28.85465 1.000 29.54285 ?  52  PRO   A N   1 
ATOM   385  C CA  . PRO   A 1 52  ? -24.09302 6.84349  -30.31075 1.000 27.46086 ?  52  PRO   A CA  1 
ATOM   386  C C   . PRO   A 1 52  ? -23.48235 5.54527  -30.80525 1.000 28.06863 ?  52  PRO   A C   1 
ATOM   387  O O   . PRO   A 1 52  ? -22.47404 5.05218  -30.29371 1.000 26.39874 ?  52  PRO   A O   1 
ATOM   388  C CB  . PRO   A 1 52  ? -23.30876 8.05892  -30.82696 1.000 31.37333 ?  52  PRO   A CB  1 
ATOM   389  C CG  . PRO   A 1 52  ? -22.35956 8.37472  -29.72625 1.000 29.54812 ?  52  PRO   A CG  1 
ATOM   390  C CD  . PRO   A 1 52  ? -23.06592 8.03285  -28.44738 1.000 31.41476 ?  52  PRO   A CD  1 
ATOM   391  N N   . ASN   A 1 53  ? -24.11970 4.97807  -31.80707 1.000 22.84271 ?  53  ASN   A N   1 
ATOM   392  C CA  . ASN   A 1 53  ? -23.53073 3.87805  -32.55086 1.000 25.00856 ?  53  ASN   A CA  1 
ATOM   393  C C   . ASN   A 1 53  ? -22.96622 4.51170  -33.82328 1.000 24.51017 ?  53  ASN   A C   1 
ATOM   394  O O   . ASN   A 1 53  ? -23.65258 4.63545  -34.84058 1.000 22.81575 ?  53  ASN   A O   1 
ATOM   395  C CB  . ASN   A 1 53  ? -24.56809 2.78805  -32.81317 1.000 23.65863 ?  53  ASN   A CB  1 
ATOM   396  C CG  . ASN   A 1 53  ? -23.98658 1.59910  -33.52432 1.000 23.81519 ?  53  ASN   A CG  1 
ATOM   397  O OD1 . ASN   A 1 53  ? -22.93573 1.69466  -34.17320 1.000 25.10552 ?  53  ASN   A OD1 1 
ATOM   398  N ND2 . ASN   A 1 53  ? -24.65663 0.45595  -33.40671 1.000 24.89106 ?  53  ASN   A ND2 1 
ATOM   399  N N   . TYR   A 1 54  ? -21.68844 4.90974  -33.75761 1.000 22.40304 ?  54  TYR   A N   1 
ATOM   400  C CA  . TYR   A 1 54  ? -21.09026 5.68254  -34.84316 1.000 24.72306 ?  54  TYR   A CA  1 
ATOM   401  C C   . TYR   A 1 54  ? -21.04981 4.89587  -36.14538 1.000 22.98502 ?  54  TYR   A C   1 
ATOM   402  O O   . TYR   A 1 54  ? -21.26031 5.45522  -37.22818 1.000 20.85993 ?  54  TYR   A O   1 
ATOM   403  C CB  . TYR   A 1 54  ? -19.67688 6.12677  -34.46271 1.000 22.51164 ?  54  TYR   A CB  1 
ATOM   404  C CG  . TYR   A 1 54  ? -19.65207 7.20985  -33.40513 1.000 24.98847 ?  54  TYR   A CG  1 
ATOM   405  C CD1 . TYR   A 1 54  ? -20.01179 8.51083  -33.71204 1.000 26.02281 ?  54  TYR   A CD1 1 
ATOM   406  C CD2 . TYR   A 1 54  ? -19.27371 6.92468  -32.10916 1.000 24.54948 ?  54  TYR   A CD2 1 
ATOM   407  C CE1 . TYR   A 1 54  ? -19.98361 9.50139  -32.74922 1.000 24.69023 ?  54  TYR   A CE1 1 
ATOM   408  C CE2 . TYR   A 1 54  ? -19.23782 7.89956  -31.14573 1.000 26.80909 ?  54  TYR   A CE2 1 
ATOM   409  C CZ  . TYR   A 1 54  ? -19.59003 9.18754  -31.47753 1.000 22.51534 ?  54  TYR   A CZ  1 
ATOM   410  O OH  . TYR   A 1 54  ? -19.54138 10.14819 -30.51066 1.000 24.51529 ?  54  TYR   A OH  1 
ATOM   411  N N   . GLU   A 1 55  ? -20.72241 3.61069  -36.07396 1.000 24.77513 ?  55  GLU   A N   1 
ATOM   412  C CA  . GLU   A 1 55  ? -20.71157 2.82514  -37.30041 1.000 26.83723 ?  55  GLU   A CA  1 
ATOM   413  C C   . GLU   A 1 55  ? -22.09464 2.82821  -37.94216 1.000 22.85600 ?  55  GLU   A C   1 
ATOM   414  O O   . GLU   A 1 55  ? -22.22346 2.92044  -39.16689 1.000 21.42850 ?  55  GLU   A O   1 
ATOM   415  C CB  . GLU   A 1 55  ? -20.24137 1.39760  -37.01222 1.000 26.57763 ?  55  GLU   A CB  1 
ATOM   416  C CG  . GLU   A 1 55  ? -18.78612 1.27230  -36.57384 1.000 23.77413 ?  55  GLU   A CG  1 
ATOM   417  C CD  . GLU   A 1 55  ? -18.59740 1.44244  -35.08015 1.000 32.18338 ?  55  GLU   A CD  1 
ATOM   418  O OE1 . GLU   A 1 55  ? -19.49943 2.00000  -34.40195 1.000 26.21086 ?  55  GLU   A OE1 1 
ATOM   419  O OE2 . GLU   A 1 55  ? -17.53109 1.01496  -34.57668 1.000 32.80663 -1 55  GLU   A OE2 1 
ATOM   420  N N   . ASP   A 1 56  ? -23.14526 2.76970  -37.12875 1.000 26.64657 ?  56  ASP   A N   1 
ATOM   421  C CA  . ASP   A 1 56  ? -24.48477 2.78095  -37.70539 1.000 26.34758 ?  56  ASP   A CA  1 
ATOM   422  C C   . ASP   A 1 56  ? -24.81992 4.13571  -38.32096 1.000 27.46726 ?  56  ASP   A C   1 
ATOM   423  O O   . ASP   A 1 56  ? -25.42949 4.19890  -39.39511 1.000 29.72252 ?  56  ASP   A O   1 
ATOM   424  C CB  . ASP   A 1 56  ? -25.53066 2.40682  -36.65624 1.000 25.75336 ?  56  ASP   A CB  1 
ATOM   425  C CG  . ASP   A 1 56  ? -26.93650 2.36240  -37.23535 1.000 28.70646 ?  56  ASP   A CG  1 
ATOM   426  O OD1 . ASP   A 1 56  ? -27.09631 1.79717  -38.34279 1.000 33.91559 ?  56  ASP   A OD1 1 
ATOM   427  O OD2 . ASP   A 1 56  ? -27.87196 2.89106  -36.59738 1.000 35.57648 -1 56  ASP   A OD2 1 
ATOM   428  N N   . LEU   A 1 57  ? -24.46045 5.23412  -37.65563 1.000 25.43178 ?  57  LEU   A N   1 
ATOM   429  C CA  . LEU   A 1 57  ? -24.78179 6.53631  -38.23239 1.000 23.94121 ?  57  LEU   A CA  1 
ATOM   430  C C   . LEU   A 1 57  ? -24.01222 6.78705  -39.51548 1.000 25.32466 ?  57  LEU   A C   1 
ATOM   431  O O   . LEU   A 1 57  ? -24.51311 7.48896  -40.41189 1.000 25.51425 ?  57  LEU   A O   1 
ATOM   432  C CB  . LEU   A 1 57  ? -24.49803 7.65807  -37.23724 1.000 26.66567 ?  57  LEU   A CB  1 
ATOM   433  C CG  . LEU   A 1 57  ? -25.14430 7.56078  -35.85114 1.000 29.56448 ?  57  LEU   A CG  1 
ATOM   434  C CD1 . LEU   A 1 57  ? -24.65012 8.72690  -35.02349 1.000 28.64695 ?  57  LEU   A CD1 1 
ATOM   435  C CD2 . LEU   A 1 57  ? -26.66914 7.57037  -35.94130 1.000 26.04366 ?  57  LEU   A CD2 1 
ATOM   436  N N   . LEU   A 1 58  ? -22.79990 6.22904  -39.62967 1.000 21.41551 ?  58  LEU   A N   1 
ATOM   437  C CA  . LEU   A 1 58  ? -22.01279 6.53948  -40.81425 1.000 29.82198 ?  58  LEU   A CA  1 
ATOM   438  C C   . LEU   A 1 58  ? -22.52270 5.83039  -42.06516 1.000 28.66116 ?  58  LEU   A C   1 
ATOM   439  O O   . LEU   A 1 58  ? -22.31072 6.33816  -43.17429 1.000 29.08905 ?  58  LEU   A O   1 
ATOM   440  C CB  . LEU   A 1 58  ? -20.53378 6.20461  -40.57838 1.000 27.33782 ?  58  LEU   A CB  1 
ATOM   441  C CG  . LEU   A 1 58  ? -19.54404 6.76051  -41.60606 1.000 18.95638 ?  58  LEU   A CG  1 
ATOM   442  C CD1 . LEU   A 1 58  ? -19.68834 8.27256  -41.75832 1.000 23.58521 ?  58  LEU   A CD1 1 
ATOM   443  C CD2 . LEU   A 1 58  ? -18.14135 6.40129  -41.18638 1.000 22.63608 ?  58  LEU   A CD2 1 
ATOM   444  N N   . ILE   A 1 59  ? -23.21420 4.69613  -41.91472 1.000 31.94329 ?  59  ILE   A N   1 
ATOM   445  C CA  . ILE   A 1 59  ? -23.70921 3.96652  -43.08288 1.000 33.80457 ?  59  ILE   A CA  1 
ATOM   446  C C   . ILE   A 1 59  ? -24.74680 4.78468  -43.83535 1.000 29.03038 ?  59  ILE   A C   1 
ATOM   447  O O   . ILE   A 1 59  ? -24.84658 4.70476  -45.06591 1.000 32.81819 ?  59  ILE   A O   1 
ATOM   448  C CB  . ILE   A 1 59  ? -24.28921 2.60213  -42.67383 1.000 34.33114 ?  59  ILE   A CB  1 
ATOM   449  C CG1 . ILE   A 1 59  ? -23.30687 1.85865  -41.79740 1.000 35.60006 ?  59  ILE   A CG1 1 
ATOM   450  C CG2 . ILE   A 1 59  ? -24.57053 1.76587  -43.91012 1.000 46.21420 ?  59  ILE   A CG2 1 
ATOM   451  C CD1 . ILE   A 1 59  ? -21.96224 1.66890  -42.45390 1.000 40.00291 ?  59  ILE   A CD1 1 
ATOM   452  N N   . ARG   A 1 60  ? -25.54019 5.57299  -43.11639 1.000 32.77817 ?  60  ARG   A N   1 
ATOM   453  C CA  . ARG   A 1 60  ? -26.59245 6.33827  -43.76714 1.000 34.45421 ?  60  ARG   A CA  1 
ATOM   454  C C   . ARG   A 1 60  ? -26.09596 7.65855  -44.32717 1.000 36.27760 ?  60  ARG   A C   1 
ATOM   455  O O   . ARG   A 1 60  ? -26.88408 8.38729  -44.94692 1.000 38.61527 ?  60  ARG   A O   1 
ATOM   456  C CB  . ARG   A 1 60  ? -27.75274 6.54735  -42.79168 1.000 40.94391 ?  60  ARG   A CB  1 
ATOM   457  C CG  . ARG   A 1 60  ? -28.45727 5.22760  -42.47332 1.000 44.39622 ?  60  ARG   A CG  1 
ATOM   458  C CD  . ARG   A 1 60  ? -29.82933 5.39695  -41.82949 1.000 51.36853 ?  60  ARG   A CD  1 
ATOM   459  N NE  . ARG   A 1 60  ? -29.73348 5.79307  -40.42955 1.000 58.64192 ?  60  ARG   A NE  1 
ATOM   460  C CZ  . ARG   A 1 60  ? -29.23260 5.03186  -39.46346 1.000 46.76802 ?  60  ARG   A CZ  1 
ATOM   461  N NH1 . ARG   A 1 60  ? -28.73344 3.83095  -39.71415 1.000 43.09977 ?  60  ARG   A NH1 1 
ATOM   462  N NH2 . ARG   A 1 60  ? -29.23945 5.48379  -38.21198 1.000 45.59881 ?  60  ARG   A NH2 1 
ATOM   463  N N   . LYS   A 1 61  ? -24.81266 7.97352  -44.14802 1.000 32.22076 ?  61  LYS   A N   1 
ATOM   464  C CA  . LYS   A 1 61  ? -24.21980 9.15708  -44.75430 1.000 31.05211 ?  61  LYS   A CA  1 
ATOM   465  C C   . LYS   A 1 61  ? -23.48978 8.77724  -46.04007 1.000 30.41198 ?  61  LYS   A C   1 
ATOM   466  O O   . LYS   A 1 61  ? -22.79883 7.75413  -46.10027 1.000 32.15650 ?  61  LYS   A O   1 
ATOM   467  C CB  . LYS   A 1 61  ? -23.24843 9.84587  -43.78680 1.000 31.43772 ?  61  LYS   A CB  1 
ATOM   468  C CG  . LYS   A 1 61  ? -23.80979 10.12370 -42.39540 1.000 34.94293 ?  61  LYS   A CG  1 
ATOM   469  C CD  . LYS   A 1 61  ? -24.85725 11.23071 -42.41302 1.000 33.10502 ?  61  LYS   A CD  1 
ATOM   470  C CE  . LYS   A 1 61  ? -25.30754 11.61153 -40.99322 1.000 33.52142 ?  61  LYS   A CE  1 
ATOM   471  N NZ  . LYS   A 1 61  ? -25.97345 10.49704 -40.23236 1.000 40.65236 ?  61  LYS   A NZ  1 
ATOM   472  N N   . SER   A 1 62  ? -23.64080 9.60445  -47.06205 1.000 28.45124 ?  62  SER   A N   1 
ATOM   473  C CA  . SER   A 1 62  ? -22.82372 9.52249  -48.25975 1.000 33.31208 ?  62  SER   A CA  1 
ATOM   474  C C   . SER   A 1 62  ? -21.93322 10.75796 -48.33641 1.000 30.56814 ?  62  SER   A C   1 
ATOM   475  O O   . SER   A 1 62  ? -22.10381 11.72229 -47.57568 1.000 30.40572 ?  62  SER   A O   1 
ATOM   476  C CB  . SER   A 1 62  ? -23.69275 9.39806  -49.51776 1.000 30.26902 ?  62  SER   A CB  1 
ATOM   477  O OG  . SER   A 1 62  ? -24.41890 10.59211 -49.73933 1.000 32.13214 ?  62  SER   A OG  1 
ATOM   478  N N   . ASN   A 1 63  ? -20.99003 10.71577 -49.28420 1.000 27.92911 ?  63  ASN   A N   1 
ATOM   479  C CA  . ASN   A 1 63  ? -20.03703 11.81057 -49.45850 1.000 30.14230 ?  63  ASN   A CA  1 
ATOM   480  C C   . ASN   A 1 63  ? -20.72408 13.17315 -49.43285 1.000 28.29651 ?  63  ASN   A C   1 
ATOM   481  O O   . ASN   A 1 63  ? -20.27052 14.08601 -48.73331 1.000 30.26556 ?  63  ASN   A O   1 
ATOM   482  C CB  . ASN   A 1 63  ? -19.25682 11.63255 -50.76524 1.000 24.94403 ?  63  ASN   A CB  1 
ATOM   483  C CG  . ASN   A 1 63  ? -18.29953 10.45828 -50.72321 1.000 30.46070 ?  63  ASN   A CG  1 
ATOM   484  O OD1 . ASN   A 1 63  ? -17.84845 10.04965 -49.65800 1.000 33.00872 ?  63  ASN   A OD1 1 
ATOM   485  N ND2 . ASN   A 1 63  ? -17.98027 9.91010  -51.88726 1.000 30.30455 ?  63  ASN   A ND2 1 
ATOM   486  N N   . HIS   A 1 64  ? -21.83367 13.32533 -50.16153 1.000 31.34289 ?  64  HIS   A N   1 
ATOM   487  C CA  . HIS   A 1 64  ? -22.44047 14.64629 -50.34004 1.000 32.66916 ?  64  HIS   A CA  1 
ATOM   488  C C   . HIS   A 1 64  ? -23.07110 15.18767 -49.05958 1.000 27.96728 ?  64  HIS   A C   1 
ATOM   489  O O   . HIS   A 1 64  ? -23.32567 16.39343 -48.97338 1.000 30.19875 ?  64  HIS   A O   1 
ATOM   490  C CB  . HIS   A 1 64  ? -23.49546 14.60431 -51.46089 1.000 35.55419 ?  64  HIS   A CB  1 
ATOM   491  C CG  . HIS   A 1 64  ? -23.93621 15.96310 -51.93920 1.000 39.83435 ?  64  HIS   A CG  1 
ATOM   492  N ND1 . HIS   A 1 64  ? -23.22244 16.69423 -52.87171 1.000 34.70821 ?  64  HIS   A ND1 1 
ATOM   493  C CD2 . HIS   A 1 64  ? -25.01927 16.71756 -51.61882 1.000 30.67522 ?  64  HIS   A CD2 1 
ATOM   494  C CE1 . HIS   A 1 64  ? -23.84016 17.84276 -53.09406 1.000 32.94300 ?  64  HIS   A CE1 1 
ATOM   495  N NE2 . HIS   A 1 64  ? -24.93740 17.87789 -52.35546 1.000 33.71800 ?  64  HIS   A NE2 1 
ATOM   496  N N   . ASN   A 1 65  ? -23.32554 14.33330 -48.06837 1.000 28.17721 ?  65  ASN   A N   1 
ATOM   497  C CA  . ASN   A 1 65  ? -23.86216 14.77791 -46.78592 1.000 25.66100 ?  65  ASN   A CA  1 
ATOM   498  C C   . ASN   A 1 65  ? -22.84067 15.54729 -45.94803 1.000 29.33531 ?  65  ASN   A C   1 
ATOM   499  O O   . ASN   A 1 65  ? -23.20424 16.08290 -44.90228 1.000 30.88796 ?  65  ASN   A O   1 
ATOM   500  C CB  . ASN   A 1 65  ? -24.37047 13.57450 -45.97682 1.000 30.66098 ?  65  ASN   A CB  1 
ATOM   501  C CG  . ASN   A 1 65  ? -25.29819 12.64809 -46.78732 1.000 37.75089 ?  65  ASN   A CG  1 
ATOM   502  O OD1 . ASN   A 1 65  ? -25.38155 11.44657 -46.51608 1.000 31.30150 ?  65  ASN   A OD1 1 
ATOM   503  N ND2 . ASN   A 1 65  ? -25.98198 13.20371 -47.78894 1.000 31.34184 ?  65  ASN   A ND2 1 
ATOM   504  N N   . PHE   A 1 66  ? -21.57498 15.58298 -46.34873 1.000 25.92480 ?  66  PHE   A N   1 
ATOM   505  C CA  . PHE   A 1 66  ? -20.54026 16.30619 -45.61892 1.000 28.21015 ?  66  PHE   A CA  1 
ATOM   506  C C   . PHE   A 1 66  ? -20.25187 17.61126 -46.35021 1.000 25.77666 ?  66  PHE   A C   1 
ATOM   507  O O   . PHE   A 1 66  ? -19.78915 17.60106 -47.49665 1.000 28.79434 ?  66  PHE   A O   1 
ATOM   508  C CB  . PHE   A 1 66  ? -19.27532 15.45811 -45.49203 1.000 22.75565 ?  66  PHE   A CB  1 
ATOM   509  C CG  . PHE   A 1 66  ? -19.45397 14.23650 -44.64630 1.000 28.45025 ?  66  PHE   A CG  1 
ATOM   510  C CD1 . PHE   A 1 66  ? -19.37634 14.31965 -43.26286 1.000 25.84083 ?  66  PHE   A CD1 1 
ATOM   511  C CD2 . PHE   A 1 66  ? -19.71661 13.01141 -45.22921 1.000 26.67111 ?  66  PHE   A CD2 1 
ATOM   512  C CE1 . PHE   A 1 66  ? -19.54500 13.20207 -42.47861 1.000 26.68164 ?  66  PHE   A CE1 1 
ATOM   513  C CE2 . PHE   A 1 66  ? -19.89577 11.88525 -44.45084 1.000 30.23441 ?  66  PHE   A CE2 1 
ATOM   514  C CZ  . PHE   A 1 66  ? -19.80578 11.97497 -43.07854 1.000 30.42347 ?  66  PHE   A CZ  1 
ATOM   515  N N   . LEU   A 1 67  ? -20.54992 18.73101 -45.71567 1.000 20.77661 ?  67  LEU   A N   1 
ATOM   516  C CA  . LEU   A 1 67  ? -20.27679 20.03720 -46.29435 1.000 24.76808 ?  67  LEU   A CA  1 
ATOM   517  C C   . LEU   A 1 67  ? -18.96949 20.54071 -45.69416 1.000 27.91136 ?  67  LEU   A C   1 
ATOM   518  O O   . LEU   A 1 67  ? -18.90600 20.86778 -44.50435 1.000 24.10329 ?  67  LEU   A O   1 
ATOM   519  C CB  . LEU   A 1 67  ? -21.42732 21.00210 -46.02966 1.000 27.31153 ?  67  LEU   A CB  1 
ATOM   520  C CG  . LEU   A 1 67  ? -21.15947 22.47692 -46.37770 1.000 30.22888 ?  67  LEU   A CG  1 
ATOM   521  C CD1 . LEU   A 1 67  ? -20.67069 22.67267 -47.81387 1.000 27.57343 ?  67  LEU   A CD1 1 
ATOM   522  C CD2 . LEU   A 1 67  ? -22.40426 23.32088 -46.09406 1.000 31.16668 ?  67  LEU   A CD2 1 
ATOM   523  N N   . VAL   A 1 68  ? -17.92310 20.57590 -46.50628 1.000 21.64105 ?  68  VAL   A N   1 
ATOM   524  C CA  . VAL   A 1 68  ? -16.59993 20.98890 -46.05971 1.000 22.36862 ?  68  VAL   A CA  1 
ATOM   525  C C   . VAL   A 1 68  ? -16.30882 22.33156 -46.69467 1.000 24.08196 ?  68  VAL   A C   1 
ATOM   526  O O   . VAL   A 1 68  ? -16.34967 22.46059 -47.92271 1.000 24.57241 ?  68  VAL   A O   1 
ATOM   527  C CB  . VAL   A 1 68  ? -15.52408 19.96280 -46.44110 1.000 25.74574 ?  68  VAL   A CB  1 
ATOM   528  C CG1 . VAL   A 1 68  ? -14.14566 20.46819 -46.02332 1.000 22.61430 ?  68  VAL   A CG1 1 
ATOM   529  C CG2 . VAL   A 1 68  ? -15.81083 18.61524 -45.80354 1.000 21.57122 ?  68  VAL   A CG2 1 
ATOM   530  N N   . GLN   A 1 69  ? -16.02189 23.33737 -45.87294 1.000 21.45996 ?  69  GLN   A N   1 
ATOM   531  C CA  . GLN   A 1 69  ? -15.74085 24.67460 -46.38194 1.000 23.61149 ?  69  GLN   A CA  1 
ATOM   532  C C   . GLN   A 1 69  ? -14.38910 25.16086 -45.87805 1.000 24.78084 ?  69  GLN   A C   1 
ATOM   533  O O   . GLN   A 1 69  ? -14.09942 25.07554 -44.68450 1.000 19.13929 ?  69  GLN   A O   1 
ATOM   534  C CB  . GLN   A 1 69  ? -16.84163 25.66116 -45.98065 1.000 26.96539 ?  69  GLN   A CB  1 
ATOM   535  C CG  . GLN   A 1 69  ? -18.23387 25.12083 -46.25482 1.000 34.72338 ?  69  GLN   A CG  1 
ATOM   536  C CD  . GLN   A 1 69  ? -19.32460 26.15417 -46.03959 1.000 41.69453 ?  69  GLN   A CD  1 
ATOM   537  O OE1 . GLN   A 1 69  ? -20.11012 26.06375 -45.09192 1.000 43.32539 ?  69  GLN   A OE1 1 
ATOM   538  N NE2 . GLN   A 1 69  ? -19.38449 27.13603 -46.92758 1.000 41.00718 ?  69  GLN   A NE2 1 
ATOM   539  N N   . ALA   A 1 70  ? -13.56670 25.64961 -46.79900 1.000 24.40725 ?  70  ALA   A N   1 
ATOM   540  C CA  . ALA   A 1 70  ? -12.32508 26.36447 -46.52196 1.000 24.99781 ?  70  ALA   A CA  1 
ATOM   541  C C   . ALA   A 1 70  ? -12.58112 27.82562 -46.90543 1.000 29.92535 ?  70  ALA   A C   1 
ATOM   542  O O   . ALA   A 1 70  ? -12.66944 28.17060 -48.09403 1.000 29.74455 ?  70  ALA   A O   1 
ATOM   543  C CB  . ALA   A 1 70  ? -11.15382 25.75181 -47.29193 1.000 20.56771 ?  70  ALA   A CB  1 
ATOM   544  N N   . GLY   A 1 71  ? -12.74411 28.67153 -45.89014 1.000 28.69178 ?  71  GLY   A N   1 
ATOM   545  C CA  . GLY   A 1 71  ? -13.15940 30.04333 -46.10631 1.000 39.32644 ?  71  GLY   A CA  1 
ATOM   546  C C   . GLY   A 1 71  ? -14.49962 30.11988 -46.81233 1.000 41.14254 ?  71  GLY   A C   1 
ATOM   547  O O   . GLY   A 1 71  ? -15.51091 29.62495 -46.31034 1.000 33.18552 ?  71  GLY   A O   1 
ATOM   548  N N   . ASN   A 1 72  ? -14.52319 30.73184 -47.99087 1.000 48.88276 ?  72  ASN   A N   1 
ATOM   549  C CA  . ASN   A 1 72  ? -15.74754 30.84626 -48.77352 1.000 53.68459 ?  72  ASN   A CA  1 
ATOM   550  C C   . ASN   A 1 72  ? -15.77446 29.86222 -49.93317 1.000 52.37911 ?  72  ASN   A C   1 
ATOM   551  O O   . ASN   A 1 72  ? -16.43913 30.11369 -50.94391 1.000 51.82525 ?  72  ASN   A O   1 
ATOM   552  C CB  . ASN   A 1 72  ? -15.92837 32.27119 -49.29092 1.000 54.92369 ?  72  ASN   A CB  1 
ATOM   553  C CG  . ASN   A 1 72  ? -16.26298 33.24531 -48.18295 1.000 69.07470 ?  72  ASN   A CG  1 
ATOM   554  O OD1 . ASN   A 1 72  ? -17.04651 32.92777 -47.28129 1.000 63.67271 ?  72  ASN   A OD1 1 
ATOM   555  N ND2 . ASN   A 1 72  ? -15.65754 34.43375 -48.22952 1.000 69.81595 ?  72  ASN   A ND2 1 
ATOM   556  N N   . VAL   A 1 73  ? -15.05193 28.74603 -49.80822 1.000 44.62713 ?  73  VAL   A N   1 
ATOM   557  C CA  . VAL   A 1 73  ? -14.96294 27.76257 -50.88068 1.000 38.98897 ?  73  VAL   A CA  1 
ATOM   558  C C   . VAL   A 1 73  ? -15.40525 26.40741 -50.34501 1.000 32.79401 ?  73  VAL   A C   1 
ATOM   559  O O   . VAL   A 1 73  ? -14.85977 25.92112 -49.34627 1.000 29.93481 ?  73  VAL   A O   1 
ATOM   560  C CB  . VAL   A 1 73  ? -13.53519 27.69035 -51.45770 1.000 40.72814 ?  73  VAL   A CB  1 
ATOM   561  C CG1 . VAL   A 1 73  ? -13.39424 26.53022 -52.44164 1.000 37.10043 ?  73  VAL   A CG1 1 
ATOM   562  C CG2 . VAL   A 1 73  ? -13.18278 29.00732 -52.11671 1.000 42.43839 ?  73  VAL   A CG2 1 
ATOM   563  N N   . GLN   A 1 74  ? -16.38988 25.79829 -51.00697 1.000 28.47027 ?  74  GLN   A N   1 
ATOM   564  C CA  . GLN   A 1 74  ? -16.76501 24.42545 -50.69468 1.000 31.82487 ?  74  GLN   A CA  1 
ATOM   565  C C   . GLN   A 1 74  ? -15.74793 23.46354 -51.30732 1.000 30.18572 ?  74  GLN   A C   1 
ATOM   566  O O   . GLN   A 1 74  ? -15.34456 23.62463 -52.46046 1.000 31.01489 ?  74  GLN   A O   1 
ATOM   567  C CB  . GLN   A 1 74  ? -18.18105 24.11944 -51.20362 1.000 29.94309 ?  74  GLN   A CB  1 
ATOM   568  C CG  . GLN   A 1 74  ? -18.68393 22.73113 -50.83362 1.000 29.71745 ?  74  GLN   A CG  1 
ATOM   569  C CD  . GLN   A 1 74  ? -20.12128 22.47113 -51.25645 1.000 37.97586 ?  74  GLN   A CD  1 
ATOM   570  O OE1 . GLN   A 1 74  ? -20.78979 23.33914 -51.81614 1.000 37.86652 ?  74  GLN   A OE1 1 
ATOM   571  N NE2 . GLN   A 1 74  ? -20.60143 21.26378 -50.98987 1.000 35.64210 ?  74  GLN   A NE2 1 
ATOM   572  N N   . LEU   A 1 75  ? -15.30585 22.49094 -50.51615 1.000 27.32850 ?  75  LEU   A N   1 
ATOM   573  C CA  . LEU   A 1 75  ? -14.46080 21.39299 -50.97237 1.000 25.17246 ?  75  LEU   A CA  1 
ATOM   574  C C   . LEU   A 1 75  ? -15.34489 20.17137 -51.17969 1.000 28.94882 ?  75  LEU   A C   1 
ATOM   575  O O   . LEU   A 1 75  ? -15.98295 19.69427 -50.23389 1.000 33.80181 ?  75  LEU   A O   1 
ATOM   576  C CB  . LEU   A 1 75  ? -13.37133 21.07572 -49.94726 1.000 24.72389 ?  75  LEU   A CB  1 
ATOM   577  C CG  . LEU   A 1 75  ? -12.40741 22.20038 -49.55629 1.000 32.13253 ?  75  LEU   A CG  1 
ATOM   578  C CD1 . LEU   A 1 75  ? -11.36872 21.70357 -48.52735 1.000 25.72947 ?  75  LEU   A CD1 1 
ATOM   579  C CD2 . LEU   A 1 75  ? -11.73718 22.73622 -50.81568 1.000 31.60417 ?  75  LEU   A CD2 1 
ATOM   580  N N   . ARG   A 1 76  ? -15.38126 19.65843 -52.39855 1.000 29.28370 ?  76  ARG   A N   1 
ATOM   581  C CA  . ARG   A 1 76  ? -16.26029 18.53153 -52.68645 1.000 31.93248 ?  76  ARG   A CA  1 
ATOM   582  C C   . ARG   A 1 76  ? -15.69134 17.26506 -52.06797 1.000 27.75943 ?  76  ARG   A C   1 
ATOM   583  O O   . ARG   A 1 76  ? -14.55223 16.89350 -52.35682 1.000 28.26731 ?  76  ARG   A O   1 
ATOM   584  C CB  . ARG   A 1 76  ? -16.41826 18.36074 -54.19386 1.000 36.52662 ?  76  ARG   A CB  1 
ATOM   585  C CG  . ARG   A 1 76  ? -17.26549 17.18349 -54.61717 1.000 28.64010 ?  76  ARG   A CG  1 
ATOM   586  C CD  . ARG   A 1 76  ? -17.43098 17.19747 -56.13275 1.000 32.51873 ?  76  ARG   A CD  1 
ATOM   587  N NE  . ARG   A 1 76  ? -18.37799 16.18749 -56.57615 1.000 34.95850 ?  76  ARG   A NE  1 
ATOM   588  C CZ  . ARG   A 1 76  ? -19.69435 16.33095 -56.49518 1.000 38.97352 ?  76  ARG   A CZ  1 
ATOM   589  N NH1 . ARG   A 1 76  ? -20.23548 17.42695 -55.98635 1.000 35.58041 ?  76  ARG   A NH1 1 
ATOM   590  N NH2 . ARG   A 1 76  ? -20.48680 15.35342 -56.93701 1.000 30.30976 ?  76  ARG   A NH2 1 
ATOM   591  N N   . VAL   A 1 77  ? -16.47758 16.59940 -51.22648 1.000 27.18008 ?  77  VAL   A N   1 
ATOM   592  C CA  . VAL   A 1 77  ? -16.06206 15.33456 -50.62979 1.000 26.25718 ?  77  VAL   A CA  1 
ATOM   593  C C   . VAL   A 1 77  ? -16.22243 14.22376 -51.65683 1.000 30.51672 ?  77  VAL   A C   1 
ATOM   594  O O   . VAL   A 1 77  ? -17.29798 14.05583 -52.23802 1.000 29.14890 ?  77  VAL   A O   1 
ATOM   595  C CB  . VAL   A 1 77  ? -16.87854 15.04421 -49.36492 1.000 25.65479 ?  77  VAL   A CB  1 
ATOM   596  C CG1 . VAL   A 1 77  ? -16.56763 13.65824 -48.82235 1.000 28.96921 ?  77  VAL   A CG1 1 
ATOM   597  C CG2 . VAL   A 1 77  ? -16.59317 16.09493 -48.31799 1.000 25.74884 ?  77  VAL   A CG2 1 
ATOM   598  N N   . ILE   A 1 78  ? -15.15835 13.45117 -51.87764 1.000 26.87481 ?  78  ILE   A N   1 
ATOM   599  C CA  . ILE   A 1 78  ? -15.18511 12.34278 -52.82175 1.000 28.69848 ?  78  ILE   A CA  1 
ATOM   600  C C   . ILE   A 1 78  ? -14.91023 11.01586 -52.14019 1.000 27.51160 ?  78  ILE   A C   1 
ATOM   601  O O   . ILE   A 1 78  ? -14.77782 9.99287  -52.81270 1.000 35.01800 ?  78  ILE   A O   1 
ATOM   602  C CB  . ILE   A 1 78  ? -14.19571 12.55753 -53.98530 1.000 26.86844 ?  78  ILE   A CB  1 
ATOM   603  C CG1 . ILE   A 1 78  ? -12.75075 12.32229 -53.51574 1.000 27.78319 ?  78  ILE   A CG1 1 
ATOM   604  C CG2 . ILE   A 1 78  ? -14.37818 13.94659 -54.59486 1.000 29.95533 ?  78  ILE   A CG2 1 
ATOM   605  C CD1 . ILE   A 1 78  ? -11.71464 12.42913 -54.66422 1.000 26.80909 ?  78  ILE   A CD1 1 
ATOM   606  N N   . GLY   A 1 79  ? -14.75937 11.01582 -50.82001 1.000 28.30648 ?  79  GLY   A N   1 
ATOM   607  C CA  . GLY   A 1 79  ? -14.64778 9.74163  -50.13524 1.000 24.46789 ?  79  GLY   A CA  1 
ATOM   608  C C   . GLY   A 1 79  ? -14.73788 9.92940  -48.63679 1.000 30.63357 ?  79  GLY   A C   1 
ATOM   609  O O   . GLY   A 1 79  ? -14.53196 11.04529 -48.15490 1.000 27.59029 ?  79  GLY   A O   1 
ATOM   610  N N   . HIS   A 1 80  ? -15.02259 8.87501  -47.87460 1.000 28.89971 ?  80  HIS   A N   1 
ATOM   611  C CA  . HIS   A 1 80  ? -15.03391 9.02426  -46.42374 1.000 29.06506 ?  80  HIS   A CA  1 
ATOM   612  C C   . HIS   A 1 80  ? -14.75578 7.68482  -45.76338 1.000 30.48256 ?  80  HIS   A C   1 
ATOM   613  O O   . HIS   A 1 80  ? -15.12820 6.63537  -46.29601 1.000 31.49373 ?  80  HIS   A O   1 
ATOM   614  C CB  . HIS   A 1 80  ? -16.36361 9.60035  -45.92562 1.000 24.06817 ?  80  HIS   A CB  1 
ATOM   615  C CG  . HIS   A 1 80  ? -17.53098 8.67362  -46.07516 1.000 31.61052 ?  80  HIS   A CG  1 
ATOM   616  N ND1 . HIS   A 1 80  ? -18.35436 8.68278  -47.18366 1.000 35.01142 ?  80  HIS   A ND1 1 
ATOM   617  C CD2 . HIS   A 1 80  ? -18.03463 7.72899  -45.24073 1.000 33.70089 ?  80  HIS   A CD2 1 
ATOM   618  C CE1 . HIS   A 1 80  ? -19.31066 7.78201  -47.02732 1.000 34.73191 ?  80  HIS   A CE1 1 
ATOM   619  N NE2 . HIS   A 1 80  ? -19.13435 7.18284  -45.86073 1.000 32.44344 ?  80  HIS   A NE2 1 
ATOM   620  N N   . SER   A 1 81  ? -14.07147 7.73345  -44.61911 1.000 24.74918 ?  81  SER   A N   1 
ATOM   621  C CA  . SER   A 1 81  ? -13.88411 6.55819  -43.77935 1.000 22.26469 ?  81  SER   A CA  1 
ATOM   622  C C   . SER   A 1 81  ? -13.72255 6.99544  -42.33105 1.000 30.13663 ?  81  SER   A C   1 
ATOM   623  O O   . SER   A 1 81  ? -13.51543 8.16988  -42.02455 1.000 28.22823 ?  81  SER   A O   1 
ATOM   624  C CB  . SER   A 1 81  ? -12.68909 5.70054  -44.22544 1.000 21.54209 ?  81  SER   A CB  1 
ATOM   625  O OG  . SER   A 1 81  ? -11.47140 6.41110  -44.22139 1.000 28.54013 ?  81  SER   A OG  1 
ATOM   626  N N   . MET   A 1 82  ? -13.83670 6.02820  -41.43360 1.000 22.58369 ?  82  MET   A N   1 
ATOM   627  C CA  . MET   A 1 82  ? -13.70676 6.25438  -40.00814 1.000 25.95035 ?  82  MET   A CA  1 
ATOM   628  C C   . MET   A 1 82  ? -12.46099 5.53100  -39.52934 1.000 26.61559 ?  82  MET   A C   1 
ATOM   629  O O   . MET   A 1 82  ? -12.26273 4.36241  -39.87018 1.000 24.55863 ?  82  MET   A O   1 
ATOM   630  C CB  . MET   A 1 82  ? -14.94163 5.73788  -39.27151 1.000 22.67413 ?  82  MET   A CB  1 
ATOM   631  C CG  . MET   A 1 82  ? -15.01944 6.17765  -37.84047 1.000 26.18959 ?  82  MET   A CG  1 
ATOM   632  S SD  . MET   A 1 82  ? -16.65341 5.80295  -37.14027 1.000 32.73257 ?  82  MET   A SD  1 
ATOM   633  C CE  . MET   A 1 82  ? -16.13211 4.77002  -35.83149 1.000 25.58880 ?  82  MET   A CE  1 
ATOM   634  N N   . GLN   A 1 83  ? -11.62704 6.22469  -38.74979 1.000 24.89781 ?  83  GLN   A N   1 
ATOM   635  C CA  . GLN   A 1 83  ? -10.43142 5.64872  -38.13988 1.000 24.18241 ?  83  GLN   A CA  1 
ATOM   636  C C   . GLN   A 1 83  ? -10.51333 5.92875  -36.65081 1.000 22.70269 ?  83  GLN   A C   1 
ATOM   637  O O   . GLN   A 1 83  ? -10.24790 7.05241  -36.20696 1.000 25.84303 ?  83  GLN   A O   1 
ATOM   638  C CB  . GLN   A 1 83  ? -9.14565  6.21444  -38.73653 1.000 26.71980 ?  83  GLN   A CB  1 
ATOM   639  C CG  . GLN   A 1 83  ? -7.92112  5.56299  -38.09451 1.000 27.53629 ?  83  GLN   A CG  1 
ATOM   640  C CD  . GLN   A 1 83  ? -6.61393  5.95726  -38.73877 1.000 25.47205 ?  83  GLN   A CD  1 
ATOM   641  O OE1 . GLN   A 1 83  ? -6.53423  6.92928  -39.48971 1.000 25.35650 ?  83  GLN   A OE1 1 
ATOM   642  N NE2 . GLN   A 1 83  ? -5.56699  5.19629  -38.43400 1.000 27.82383 ?  83  GLN   A NE2 1 
ATOM   643  N N   . ASN   A 1 84  ? -10.88753 4.89979  -35.89428 1.000 23.37355 ?  84  ASN   A N   1 
ATOM   644  C CA  . ASN   A 1 84  ? -11.18246 5.03412  -34.47513 1.000 23.87645 ?  84  ASN   A CA  1 
ATOM   645  C C   . ASN   A 1 84  ? -12.16164 6.19644  -34.29710 1.000 25.33180 ?  84  ASN   A C   1 
ATOM   646  O O   . ASN   A 1 84  ? -13.25629 6.17102  -34.86910 1.000 21.50436 ?  84  ASN   A O   1 
ATOM   647  C CB  . ASN   A 1 84  ? -9.88134  5.20885  -33.67621 1.000 25.22127 ?  84  ASN   A CB  1 
ATOM   648  C CG  . ASN   A 1 84  ? -8.87248  4.08554  -33.95327 1.000 26.01474 ?  84  ASN   A CG  1 
ATOM   649  O OD1 . ASN   A 1 84  ? -9.05500  2.95484  -33.51287 1.000 28.87670 ?  84  ASN   A OD1 1 
ATOM   650  N ND2 . ASN   A 1 84  ? -7.80701  4.40253  -34.67105 1.000 23.50796 ?  84  ASN   A ND2 1 
ATOM   651  N N   . CYS   A 1 85  ? -11.78112 7.24549  -33.56751 1.000 21.12073 ?  85  CYS   A N   1 
ATOM   652  C CA  . CYS   A 1 85  ? -12.73315 8.30160  -33.25971 1.000 18.35096 ?  85  CYS   A CA  1 
ATOM   653  C C   . CYS   A 1 85  ? -12.65865 9.47716  -34.22086 1.000 23.24090 ?  85  CYS   A C   1 
ATOM   654  O O   . CYS   A 1 85  ? -13.31618 10.49805 -33.97728 1.000 21.69627 ?  85  CYS   A O   1 
ATOM   655  C CB  . CYS   A 1 85  ? -12.55180 8.77998  -31.81862 1.000 19.61208 ?  85  CYS   A CB  1 
ATOM   656  S SG  . CYS   A 1 85  ? -13.00956 7.52584  -30.56918 1.000 22.76261 ?  85  CYS   A SG  1 
ATOM   657  N N   . VAL   A 1 86  ? -11.89591 9.37076  -35.31178 1.000 19.89033 ?  86  VAL   A N   1 
ATOM   658  C CA  . VAL   A 1 86  ? -11.86983 10.47009 -36.26852 1.000 21.78258 ?  86  VAL   A CA  1 
ATOM   659  C C   . VAL   A 1 86  ? -12.43727 10.00004 -37.59664 1.000 23.99839 ?  86  VAL   A C   1 
ATOM   660  O O   . VAL   A 1 86  ? -12.40098 8.81184  -37.93018 1.000 27.12127 ?  86  VAL   A O   1 
ATOM   661  C CB  . VAL   A 1 86  ? -10.45425 11.05045 -36.48383 1.000 23.99672 ?  86  VAL   A CB  1 
ATOM   662  C CG1 . VAL   A 1 86  ? -9.89953  11.60118 -35.17010 1.000 19.86424 ?  86  VAL   A CG1 1 
ATOM   663  C CG2 . VAL   A 1 86  ? -9.55636  9.99651  -37.08373 1.000 27.06279 ?  86  VAL   A CG2 1 
ATOM   664  N N   . LEU   A 1 87  ? -12.97707 10.95079 -38.34713 1.000 21.34115 ?  87  LEU   A N   1 
ATOM   665  C CA  . LEU   A 1 87  ? -13.43084 10.76743 -39.71012 1.000 23.06556 ?  87  LEU   A CA  1 
ATOM   666  C C   . LEU   A 1 87  ? -12.37319 11.31885 -40.63703 1.000 27.07375 ?  87  LEU   A C   1 
ATOM   667  O O   . LEU   A 1 87  ? -11.78597 12.37264 -40.35256 1.000 22.91886 ?  87  LEU   A O   1 
ATOM   668  C CB  . LEU   A 1 87  ? -14.72414 11.53341 -39.95614 1.000 27.28056 ?  87  LEU   A CB  1 
ATOM   669  C CG  . LEU   A 1 87  ? -16.03628 10.82133 -40.22439 1.000 32.64233 ?  87  LEU   A CG  1 
ATOM   670  C CD1 . LEU   A 1 87  ? -16.25324 9.73968  -39.18949 1.000 28.49226 ?  87  LEU   A CD1 1 
ATOM   671  C CD2 . LEU   A 1 87  ? -17.13492 11.87771 -40.16612 1.000 26.49128 ?  87  LEU   A CD2 1 
ATOM   672  N N   . LYS   A 1 88  ? -12.15810 10.62378 -41.75525 1.000 23.59052 ?  88  LYS   A N   1 
ATOM   673  C CA  . LYS   A 1 88  ? -11.30207 11.09837 -42.83241 1.000 24.45734 ?  88  LYS   A CA  1 
ATOM   674  C C   . LYS   A 1 88  ? -12.16710 11.28224 -44.07033 1.000 22.87568 ?  88  LYS   A C   1 
ATOM   675  O O   . LYS   A 1 88  ? -12.79612 10.33455 -44.55165 1.000 22.43120 ?  88  LYS   A O   1 
ATOM   676  C CB  . LYS   A 1 88  ? -10.13454 10.14164 -43.07714 1.000 22.10799 ?  88  LYS   A CB  1 
ATOM   677  C CG  . LYS   A 1 88  ? -9.28061  9.93573  -41.82234 1.000 27.92720 ?  88  LYS   A CG  1 
ATOM   678  C CD  . LYS   A 1 88  ? -8.06515  9.02301  -42.05419 1.000 33.12093 ?  88  LYS   A CD  1 
ATOM   679  C CE  . LYS   A 1 88  ? -8.45109  7.55391  -42.16065 1.000 32.43787 ?  88  LYS   A CE  1 
ATOM   680  N NZ  . LYS   A 1 88  ? -7.24007  6.69908  -42.01355 1.000 34.18652 ?  88  LYS   A NZ  1 
ATOM   681  N N   . LEU   A 1 89  ? -12.22404 12.51313 -44.54903 1.000 19.07191 ?  89  LEU   A N   1 
ATOM   682  C CA  . LEU   A 1 89  ? -13.01517 12.90350 -45.70453 1.000 23.50068 ?  89  LEU   A CA  1 
ATOM   683  C C   . LEU   A 1 89  ? -12.05812 13.20943 -46.83744 1.000 22.56816 ?  89  LEU   A C   1 
ATOM   684  O O   . LEU   A 1 89  ? -11.31177 14.18169 -46.76319 1.000 22.03510 ?  89  LEU   A O   1 
ATOM   685  C CB  . LEU   A 1 89  ? -13.85737 14.14330 -45.40031 1.000 18.76784 ?  89  LEU   A CB  1 
ATOM   686  C CG  . LEU   A 1 89  ? -14.70792 14.07119 -44.13080 1.000 22.87855 ?  89  LEU   A CG  1 
ATOM   687  C CD1 . LEU   A 1 89  ? -15.42362 15.39369 -43.90580 1.000 18.42753 ?  89  LEU   A CD1 1 
ATOM   688  C CD2 . LEU   A 1 89  ? -15.70205 12.91851 -44.22107 1.000 22.87743 ?  89  LEU   A CD2 1 
ATOM   689  N N   . LYS   A 1 90  ? -12.06808 12.39138 -47.86992 1.000 21.76875 ?  90  LYS   A N   1 
ATOM   690  C CA  . LYS   A 1 90  ? -11.26173 12.68568 -49.03263 1.000 26.02890 ?  90  LYS   A CA  1 
ATOM   691  C C   . LYS   A 1 90  ? -11.99711 13.71699 -49.86280 1.000 25.98355 ?  90  LYS   A C   1 
ATOM   692  O O   . LYS   A 1 90  ? -13.19744 13.55683 -50.12680 1.000 27.03034 ?  90  LYS   A O   1 
ATOM   693  C CB  . LYS   A 1 90  ? -11.00553 11.41248 -49.83221 1.000 26.66107 ?  90  LYS   A CB  1 
ATOM   694  C CG  . LYS   A 1 90  ? -9.95710  11.58057 -50.91521 1.000 26.72634 ?  90  LYS   A CG  1 
ATOM   695  C CD  . LYS   A 1 90  ? -9.66328  10.25456 -51.59902 1.000 35.10733 ?  90  LYS   A CD  1 
ATOM   696  C CE  . LYS   A 1 90  ? -8.64916  10.46616 -52.69608 1.000 47.51222 ?  90  LYS   A CE  1 
ATOM   697  N NZ  . LYS   A 1 90  ? -8.87712  9.49105  -53.79547 1.000 56.01976 ?  90  LYS   A NZ  1 
ATOM   698  N N   . VAL   A 1 91  ? -11.25717 14.74220 -50.30772 1.000 26.00149 ?  91  VAL   A N   1 
ATOM   699  C CA  . VAL   A 1 91  ? -11.78824 15.86330 -51.07465 1.000 25.95283 ?  91  VAL   A CA  1 
ATOM   700  C C   . VAL   A 1 91  ? -11.03579 15.94735 -52.39907 1.000 28.16642 ?  91  VAL   A C   1 
ATOM   701  O O   . VAL   A 1 91  ? -9.92115  15.43497 -52.53967 1.000 29.97975 ?  91  VAL   A O   1 
ATOM   702  C CB  . VAL   A 1 91  ? -11.67204 17.19897 -50.30029 1.000 23.67395 ?  91  VAL   A CB  1 
ATOM   703  C CG1 . VAL   A 1 91  ? -12.58938 17.20263 -49.07536 1.000 23.83047 ?  91  VAL   A CG1 1 
ATOM   704  C CG2 . VAL   A 1 91  ? -10.23198 17.40571 -49.87425 1.000 24.41638 ?  91  VAL   A CG2 1 
ATOM   705  N N   . ASP   A 1 92  ? -11.64664 16.62920 -53.37345 1.000 25.82313 ?  92  ASP   A N   1 
ATOM   706  C CA  . ASP   A 1 92  ? -11.09670 16.68740 -54.72869 1.000 30.58511 ?  92  ASP   A CA  1 
ATOM   707  C C   . ASP   A 1 92  ? -10.03851 17.75954 -54.90936 1.000 34.85212 ?  92  ASP   A C   1 
ATOM   708  O O   . ASP   A 1 92  ? -9.69565  18.07543 -56.05130 1.000 36.49181 ?  92  ASP   A O   1 
ATOM   709  C CB  . ASP   A 1 92  ? -12.22456 16.90472 -55.75285 1.000 33.46550 ?  92  ASP   A CB  1 
ATOM   710  C CG  . ASP   A 1 92  ? -12.86842 18.30463 -55.67423 1.000 35.81634 ?  92  ASP   A CG  1 
ATOM   711  O OD1 . ASP   A 1 92  ? -12.57801 19.09309 -54.74583 1.000 37.22133 ?  92  ASP   A OD1 1 
ATOM   712  O OD2 . ASP   A 1 92  ? -13.69082 18.61558 -56.57061 1.000 40.89251 -1 92  ASP   A OD2 1 
ATOM   713  N N   . THR   A 1 93  ? -9.52831  18.33827 -53.82608 1.000 30.42281 ?  93  THR   A N   1 
ATOM   714  C CA  . THR   A 1 93  ? -8.55084  19.41455 -53.89582 1.000 27.80136 ?  93  THR   A CA  1 
ATOM   715  C C   . THR   A 1 93  ? -7.52254  19.18669 -52.79491 1.000 29.98706 ?  93  THR   A C   1 
ATOM   716  O O   . THR   A 1 93  ? -7.88205  18.96386 -51.63407 1.000 27.73128 ?  93  THR   A O   1 
ATOM   717  C CB  . THR   A 1 93  ? -9.22014  20.78928 -53.73824 1.000 28.80940 ?  93  THR   A CB  1 
ATOM   718  O OG1 . THR   A 1 93  ? -10.28481 20.92121 -54.69049 1.000 35.55284 ?  93  THR   A OG1 1 
ATOM   719  C CG2 . THR   A 1 93  ? -8.19360  21.92018 -53.96289 1.000 35.54408 ?  93  THR   A CG2 1 
ATOM   720  N N   . ALA   A 1 94  ? -6.25145  19.20465 -53.15959 1.000 26.69361 ?  94  ALA   A N   1 
ATOM   721  C CA  . ALA   A 1 94  ? -5.20667  19.11479 -52.15458 1.000 25.91506 ?  94  ALA   A CA  1 
ATOM   722  C C   . ALA   A 1 94  ? -4.92919  20.50384 -51.60004 1.000 24.38475 ?  94  ALA   A C   1 
ATOM   723  O O   . ALA   A 1 94  ? -4.88792  21.48570 -52.34310 1.000 25.68349 ?  94  ALA   A O   1 
ATOM   724  C CB  . ALA   A 1 94  ? -3.93553  18.50756 -52.74343 1.000 22.33973 ?  94  ALA   A CB  1 
ATOM   725  N N   . ASN   A 1 95  ? -4.77745  20.59280 -50.28975 1.000 25.21150 ?  95  ASN   A N   1 
ATOM   726  C CA  . ASN   A 1 95  ? -4.56401  21.90134 -49.67533 1.000 24.08941 ?  95  ASN   A CA  1 
ATOM   727  C C   . ASN   A 1 95  ? -3.22709  22.48426 -50.12005 1.000 22.18618 ?  95  ASN   A C   1 
ATOM   728  O O   . ASN   A 1 95  ? -2.17231  21.93560 -49.77200 1.000 23.31245 ?  95  ASN   A O   1 
ATOM   729  C CB  . ASN   A 1 95  ? -4.61746  21.77593 -48.15213 1.000 21.28780 ?  95  ASN   A CB  1 
ATOM   730  C CG  . ASN   A 1 95  ? -4.43700  23.11013 -47.43779 1.000 20.26773 ?  95  ASN   A CG  1 
ATOM   731  O OD1 . ASN   A 1 95  ? -4.29200  24.17196 -48.05938 1.000 19.82988 ?  95  ASN   A OD1 1 
ATOM   732  N ND2 . ASN   A 1 95  ? -4.47677  23.05983 -46.11059 1.000 23.67759 ?  95  ASN   A ND2 1 
ATOM   733  N N   . PRO   A 1 96  ? -3.21294  23.60262 -50.85491 1.000 23.16423 ?  96  PRO   A N   1 
ATOM   734  C CA  . PRO   A 1 96  ? -1.91796  24.15494 -51.28719 1.000 28.95425 ?  96  PRO   A CA  1 
ATOM   735  C C   . PRO   A 1 96  ? -1.07716  24.65104 -50.12479 1.000 26.28896 ?  96  PRO   A C   1 
ATOM   736  O O   . PRO   A 1 96  ? 0.14115   24.77997 -50.27440 1.000 27.37712 ?  96  PRO   A O   1 
ATOM   737  C CB  . PRO   A 1 96  ? -2.31234  25.29810 -52.23746 1.000 23.05060 ?  96  PRO   A CB  1 
ATOM   738  C CG  . PRO   A 1 96  ? -3.68504  25.66815 -51.81264 1.000 23.72807 ?  96  PRO   A CG  1 
ATOM   739  C CD  . PRO   A 1 96  ? -4.34600  24.41415 -51.33492 1.000 17.47829 ?  96  PRO   A CD  1 
ATOM   740  N N   . LYS   A 1 97  ? -1.68190  24.89125 -48.96262 1.000 21.72235 ?  97  LYS   A N   1 
ATOM   741  C CA  . LYS   A 1 97  ? -0.96937  25.37262 -47.79160 1.000 23.48291 ?  97  LYS   A CA  1 
ATOM   742  C C   . LYS   A 1 97  ? -0.55812  24.24140 -46.86044 1.000 21.92699 ?  97  LYS   A C   1 
ATOM   743  O O   . LYS   A 1 97  ? -0.25660  24.49297 -45.69888 1.000 25.11057 ?  97  LYS   A O   1 
ATOM   744  C CB  . LYS   A 1 97  ? -1.82533  26.39492 -47.03470 1.000 21.81531 ?  97  LYS   A CB  1 
ATOM   745  C CG  . LYS   A 1 97  ? -2.26483  27.57970 -47.87722 1.000 24.15607 ?  97  LYS   A CG  1 
ATOM   746  C CD  . LYS   A 1 97  ? -3.01208  28.62518 -47.02705 1.000 30.47074 ?  97  LYS   A CD  1 
ATOM   747  C CE  . LYS   A 1 97  ? -3.61463  29.72461 -47.90278 1.000 33.17973 ?  97  LYS   A CE  1 
ATOM   748  N NZ  . LYS   A 1 97  ? -3.74952  31.01751 -47.17163 1.000 40.74033 ?  97  LYS   A NZ  1 
ATOM   749  N N   . THR   A 1 98  ? -0.53767  23.01767 -47.33723 1.000 20.29968 ?  98  THR   A N   1 
ATOM   750  C CA  . THR   A 1 98  ? -0.15398  21.89350 -46.49675 1.000 21.32814 ?  98  THR   A CA  1 
ATOM   751  C C   . THR   A 1 98  ? 1.30325   22.04718 -46.08486 1.000 26.05519 ?  98  THR   A C   1 
ATOM   752  O O   . THR   A 1 98  ? 2.18373   22.06510 -46.95420 1.000 26.82135 ?  98  THR   A O   1 
ATOM   753  C CB  . THR   A 1 98  ? -0.35131  20.56376 -47.23048 1.000 23.56179 ?  98  THR   A CB  1 
ATOM   754  O OG1 . THR   A 1 98  ? -1.73509  20.38920 -47.55067 1.000 26.65943 ?  98  THR   A OG1 1 
ATOM   755  C CG2 . THR   A 1 98  ? 0.08504   19.40463 -46.35313 1.000 21.34714 ?  98  THR   A CG2 1 
ATOM   756  N N   . PRO   A 1 99  ? 1.60392   22.16057 -44.79905 1.000 20.43592 ?  99  PRO   A N   1 
ATOM   757  C CA  . PRO   A 1 99  ? 2.99940   22.18758 -44.36169 1.000 19.89412 ?  99  PRO   A CA  1 
ATOM   758  C C   . PRO   A 1 99  ? 3.54714   20.77378 -44.32597 1.000 22.57228 ?  99  PRO   A C   1 
ATOM   759  O O   . PRO   A 1 99  ? 2.79606   19.80100 -44.38390 1.000 19.12691 ?  99  PRO   A O   1 
ATOM   760  C CB  . PRO   A 1 99  ? 2.90299   22.77463 -42.95003 1.000 27.90465 ?  99  PRO   A CB  1 
ATOM   761  C CG  . PRO   A 1 99  ? 1.55393   22.24920 -42.43983 1.000 18.39142 ?  99  PRO   A CG  1 
ATOM   762  C CD  . PRO   A 1 99  ? 0.65386   22.18658 -43.66572 1.000 17.53929 ?  99  PRO   A CD  1 
ATOM   763  N N   . LYS   A 1 100 ? 4.87976   20.66715 -44.23881 1.000 22.07484 ?  100 LYS   A N   1 
ATOM   764  C CA  . LYS   A 1 100 ? 5.47203   19.39466 -43.84593 1.000 21.09729 ?  100 LYS   A CA  1 
ATOM   765  C C   . LYS   A 1 100 ? 4.94611   19.04368 -42.46216 1.000 20.07181 ?  100 LYS   A C   1 
ATOM   766  O O   . LYS   A 1 100 ? 4.89697   19.90678 -41.57543 1.000 20.36031 ?  100 LYS   A O   1 
ATOM   767  C CB  . LYS   A 1 100 ? 7.00392   19.48550 -43.83390 1.000 24.80045 ?  100 LYS   A CB  1 
ATOM   768  C CG  . LYS   A 1 100 ? 7.70904   18.16286 -43.47804 1.000 30.05519 ?  100 LYS   A CG  1 
ATOM   769  C CD  . LYS   A 1 100 ? 9.20383   18.40266 -43.13996 1.000 38.20568 ?  100 LYS   A CD  1 
ATOM   770  C CE  . LYS   A 1 100 ? 10.00537  17.09656 -42.97778 1.000 30.52635 ?  100 LYS   A CE  1 
ATOM   771  N NZ  . LYS   A 1 100 ? 11.47304  17.32358 -43.16685 1.000 32.75969 ?  100 LYS   A NZ  1 
ATOM   772  N N   . TYR   A 1 101 ? 4.51805   17.79467 -42.28167 1.000 18.35641 ?  101 TYR   A N   1 
ATOM   773  C CA  . TYR   A 1 101 ? 3.83068   17.43262 -41.05380 1.000 20.87615 ?  101 TYR   A CA  1 
ATOM   774  C C   . TYR   A 1 101 ? 4.06314   15.96782 -40.73047 1.000 23.60122 ?  101 TYR   A C   1 
ATOM   775  O O   . TYR   A 1 101 ? 4.41035   15.17415 -41.60197 1.000 20.65152 ?  101 TYR   A O   1 
ATOM   776  C CB  . TYR   A 1 101 ? 2.31793   17.70274 -41.14451 1.000 20.62895 ?  101 TYR   A CB  1 
ATOM   777  C CG  . TYR   A 1 101 ? 1.53661   16.70325 -42.00086 1.000 18.31780 ?  101 TYR   A CG  1 
ATOM   778  C CD1 . TYR   A 1 101 ? 1.31954   16.94146 -43.36071 1.000 22.08891 ?  101 TYR   A CD1 1 
ATOM   779  C CD2 . TYR   A 1 101 ? 1.01966   15.54237 -41.45519 1.000 18.25795 ?  101 TYR   A CD2 1 
ATOM   780  C CE1 . TYR   A 1 101 ? 0.62191   16.04696 -44.15651 1.000 21.63961 ?  101 TYR   A CE1 1 
ATOM   781  C CE2 . TYR   A 1 101 ? 0.31339   14.63327 -42.24860 1.000 23.51161 ?  101 TYR   A CE2 1 
ATOM   782  C CZ  . TYR   A 1 101 ? 0.11752   14.89910 -43.59692 1.000 23.94076 ?  101 TYR   A CZ  1 
ATOM   783  O OH  . TYR   A 1 101 ? -0.58464  14.01799 -44.39150 1.000 28.98042 ?  101 TYR   A OH  1 
ATOM   784  N N   . LYS   A 1 102 ? 3.84629   15.62658 -39.45565 1.000 18.66542 ?  102 LYS   A N   1 
ATOM   785  C CA  . LYS   A 1 102 ? 3.79619   14.25992 -38.95509 1.000 20.30679 ?  102 LYS   A CA  1 
ATOM   786  C C   . LYS   A 1 102 ? 2.61154   14.16536 -38.00813 1.000 20.82528 ?  102 LYS   A C   1 
ATOM   787  O O   . LYS   A 1 102 ? 2.16383   15.17945 -37.46626 1.000 21.31804 ?  102 LYS   A O   1 
ATOM   788  C CB  . LYS   A 1 102 ? 5.09057   13.87949 -38.20592 1.000 23.36448 ?  102 LYS   A CB  1 
ATOM   789  C CG  . LYS   A 1 102 ? 6.34937   13.85152 -39.06793 1.000 29.68888 ?  102 LYS   A CG  1 
ATOM   790  C CD  . LYS   A 1 102 ? 7.63098   14.21682 -38.26211 1.000 37.57276 ?  102 LYS   A CD  1 
ATOM   791  C CE  . LYS   A 1 102 ? 7.54735   13.77440 -36.78402 1.000 35.89813 ?  102 LYS   A CE  1 
ATOM   792  N NZ  . LYS   A 1 102 ? 7.60620   12.28579 -36.67313 1.000 44.65944 ?  102 LYS   A NZ  1 
ATOM   793  N N   . PHE   A 1 103 ? 2.07808   12.94932 -37.83310 1.000 23.41609 ?  103 PHE   A N   1 
ATOM   794  C CA  . PHE   A 1 103 ? 1.17470   12.63368 -36.72997 1.000 18.91507 ?  103 PHE   A CA  1 
ATOM   795  C C   . PHE   A 1 103 ? 1.99206   11.94028 -35.65239 1.000 20.52199 ?  103 PHE   A C   1 
ATOM   796  O O   . PHE   A 1 103 ? 2.65173   10.93506 -35.92297 1.000 24.13446 ?  103 PHE   A O   1 
ATOM   797  C CB  . PHE   A 1 103 ? 0.01895   11.72491 -37.15849 1.000 17.28329 ?  103 PHE   A CB  1 
ATOM   798  C CG  . PHE   A 1 103 ? -0.96047  12.37207 -38.08909 1.000 19.34631 ?  103 PHE   A CG  1 
ATOM   799  C CD1 . PHE   A 1 103 ? -0.94541  13.74568 -38.29452 1.000 20.25020 ?  103 PHE   A CD1 1 
ATOM   800  C CD2 . PHE   A 1 103 ? -1.89401  11.60362 -38.77007 1.000 20.44353 ?  103 PHE   A CD2 1 
ATOM   801  C CE1 . PHE   A 1 103 ? -1.84550  14.34691 -39.15214 1.000 15.54854 ?  103 PHE   A CE1 1 
ATOM   802  C CE2 . PHE   A 1 103 ? -2.79743  12.19013 -39.63251 1.000 20.63200 ?  103 PHE   A CE2 1 
ATOM   803  C CZ  . PHE   A 1 103 ? -2.77167  13.58076 -39.81869 1.000 22.38365 ?  103 PHE   A CZ  1 
ATOM   804  N N   . VAL   A 1 104 ? 1.95546   12.46524 -34.44106 1.000 18.86633 ?  104 VAL   A N   1 
ATOM   805  C CA  . VAL   A 1 104 ? 2.63880   11.81209 -33.33316 1.000 20.42008 ?  104 VAL   A CA  1 
ATOM   806  C C   . VAL   A 1 104 ? 1.67033   11.67631 -32.16466 1.000 20.53959 ?  104 VAL   A C   1 
ATOM   807  O O   . VAL   A 1 104 ? 0.73094   12.46349 -32.00346 1.000 21.74314 ?  104 VAL   A O   1 
ATOM   808  C CB  . VAL   A 1 104 ? 3.92554   12.55837 -32.88781 1.000 22.09297 ?  104 VAL   A CB  1 
ATOM   809  C CG1 . VAL   A 1 104 ? 4.81371   12.95263 -34.09807 1.000 20.61460 ?  104 VAL   A CG1 1 
ATOM   810  C CG2 . VAL   A 1 104 ? 3.58503   13.78235 -32.06266 1.000 20.68065 ?  104 VAL   A CG2 1 
ATOM   811  N N   . ARG   A 1 105 ? 1.90706   10.66985 -31.33625 1.000 20.83994 ?  105 ARG   A N   1 
ATOM   812  C CA  . ARG   A 1 105 ? 1.17273   10.51387 -30.09108 1.000 24.10980 ?  105 ARG   A CA  1 
ATOM   813  C C   . ARG   A 1 105 ? 2.11725   10.88816 -28.95800 1.000 23.78117 ?  105 ARG   A C   1 
ATOM   814  O O   . ARG   A 1 105 ? 3.12494   10.20745 -28.73379 1.000 27.05522 ?  105 ARG   A O   1 
ATOM   815  C CB  . ARG   A 1 105 ? 0.63430   9.09147  -29.94799 1.000 24.93907 ?  105 ARG   A CB  1 
ATOM   816  C CG  . ARG   A 1 105 ? -0.22422  8.87390  -28.70115 1.000 18.75105 ?  105 ARG   A CG  1 
ATOM   817  C CD  . ARG   A 1 105 ? -0.76429  7.46880  -28.66320 1.000 21.17469 ?  105 ARG   A CD  1 
ATOM   818  N NE  . ARG   A 1 105 ? -1.58346  7.22508  -27.47972 1.000 20.50523 ?  105 ARG   A NE  1 
ATOM   819  C CZ  . ARG   A 1 105 ? -2.87154  7.52629  -27.40413 1.000 23.21979 ?  105 ARG   A CZ  1 
ATOM   820  N NH1 . ARG   A 1 105 ? -3.48943  8.12450  -28.40341 1.000 19.78834 ?  105 ARG   A NH1 1 
ATOM   821  N NH2 . ARG   A 1 105 ? -3.55903  7.20463  -26.30327 1.000 17.04300 ?  105 ARG   A NH2 1 
ATOM   822  N N   . ILE   A 1 106 ? 1.79736   11.96478 -28.24048 1.000 21.30777 ?  106 ILE   A N   1 
ATOM   823  C CA  . ILE   A 1 106 ? 2.69579   12.42409 -27.17712 1.000 28.00662 ?  106 ILE   A CA  1 
ATOM   824  C C   . ILE   A 1 106 ? 2.47367   11.61951 -25.89865 1.000 25.71989 ?  106 ILE   A C   1 
ATOM   825  O O   . ILE   A 1 106 ? 1.44186   10.95873 -25.69883 1.000 20.98966 ?  106 ILE   A O   1 
ATOM   826  C CB  . ILE   A 1 106 ? 2.53472   13.92454 -26.89465 1.000 24.58405 ?  106 ILE   A CB  1 
ATOM   827  C CG1 . ILE   A 1 106 ? 1.07811   14.23428 -26.57585 1.000 19.89248 ?  106 ILE   A CG1 1 
ATOM   828  C CG2 . ILE   A 1 106 ? 3.05880   14.76521 -28.02931 1.000 25.39703 ?  106 ILE   A CG2 1 
ATOM   829  C CD1 . ILE   A 1 106 ? 0.92305   15.64230 -26.08213 1.000 23.49319 ?  106 ILE   A CD1 1 
ATOM   830  N N   . GLN   A 1 107 ? 3.46050   11.70111 -25.01816 1.000 19.42754 ?  107 GLN   A N   1 
ATOM   831  C CA  . GLN   A 1 107 ? 3.53844   11.11067 -23.69396 1.000 25.55169 ?  107 GLN   A CA  1 
ATOM   832  C C   . GLN   A 1 107 ? 3.01184   12.09064 -22.65742 1.000 24.83593 ?  107 GLN   A C   1 
ATOM   833  O O   . GLN   A 1 107 ? 3.08073   13.30995 -22.85500 1.000 20.94361 ?  107 GLN   A O   1 
ATOM   834  C CB  . GLN   A 1 107 ? 4.98894   10.75674 -23.36640 1.000 22.84733 ?  107 GLN   A CB  1 
ATOM   835  C CG  . GLN   A 1 107 ? 5.65729   9.83692  -24.38665 1.000 33.65349 ?  107 GLN   A CG  1 
ATOM   836  C CD  . GLN   A 1 107 ? 5.35122   8.37615  -24.12022 1.000 43.15549 ?  107 GLN   A CD  1 
ATOM   837  O OE1 . GLN   A 1 107 ? 5.49314   7.89519  -22.99578 1.000 43.62976 ?  107 GLN   A OE1 1 
ATOM   838  N NE2 . GLN   A 1 107 ? 4.92023   7.66383  -25.15302 1.000 52.98039 ?  107 GLN   A NE2 1 
ATOM   839  N N   . PRO   A 1 108 ? 2.48570   11.58781 -21.53854 1.000 21.64881 ?  108 PRO   A N   1 
ATOM   840  C CA  . PRO   A 1 108 ? 2.17372   12.47733 -20.41246 1.000 22.53446 ?  108 PRO   A CA  1 
ATOM   841  C C   . PRO   A 1 108 ? 3.39431   13.30145 -20.02899 1.000 22.75586 ?  108 PRO   A C   1 
ATOM   842  O O   . PRO   A 1 108 ? 4.53091   12.82282 -20.06964 1.000 23.72107 ?  108 PRO   A O   1 
ATOM   843  C CB  . PRO   A 1 108 ? 1.77193   11.50669 -19.29117 1.000 23.48215 ?  108 PRO   A CB  1 
ATOM   844  C CG  . PRO   A 1 108 ? 2.43719   10.19759 -19.64904 1.000 26.22974 ?  108 PRO   A CG  1 
ATOM   845  C CD  . PRO   A 1 108 ? 2.34389   10.16409 -21.17013 1.000 30.74288 ?  108 PRO   A CD  1 
ATOM   846  N N   . GLY   A 1 109 ? 3.14866   14.55790 -19.68580 1.000 21.83634 ?  109 GLY   A N   1 
ATOM   847  C CA  . GLY   A 1 109 ? 4.17906   15.48890 -19.31074 1.000 19.74749 ?  109 GLY   A CA  1 
ATOM   848  C C   . GLY   A 1 109 ? 4.69538   16.34545 -20.44518 1.000 24.28790 ?  109 GLY   A C   1 
ATOM   849  O O   . GLY   A 1 109 ? 5.35453   17.36103 -20.17962 1.000 25.66473 ?  109 GLY   A O   1 
ATOM   850  N N   . GLN   A 1 110 ? 4.43048   15.96016 -21.69645 1.000 21.02487 ?  110 GLN   A N   1 
ATOM   851  C CA  . GLN   A 1 110 ? 4.81197   16.77404 -22.83840 1.000 22.64547 ?  110 GLN   A CA  1 
ATOM   852  C C   . GLN   A 1 110 ? 3.78668   17.87334 -23.07678 1.000 20.28986 ?  110 GLN   A C   1 
ATOM   853  O O   . GLN   A 1 110 ? 2.60469   17.72982 -22.76238 1.000 17.83562 ?  110 GLN   A O   1 
ATOM   854  C CB  . GLN   A 1 110 ? 4.95270   15.91160 -24.09643 1.000 21.22795 ?  110 GLN   A CB  1 
ATOM   855  C CG  . GLN   A 1 110 ? 6.31882   15.25051 -24.16590 1.000 24.49702 ?  110 GLN   A CG  1 
ATOM   856  C CD  . GLN   A 1 110 ? 7.40383   16.29336 -24.50468 1.000 40.67397 ?  110 GLN   A CD  1 
ATOM   857  O OE1 . GLN   A 1 110 ? 8.61729   16.04371 -24.30181 1.000 52.60911 ?  110 GLN   A OE1 1 
ATOM   858  N NE2 . GLN   A 1 110 ? 6.96458   17.48236 -25.04894 1.000 46.28976 ?  110 GLN   A NE2 1 
ATOM   859  N N   . THR   A 1 111 ? 4.24853   18.96719 -23.66848 1.000 15.74171 ?  111 THR   A N   1 
ATOM   860  C CA  . THR   A 1 111 ? 3.40303   20.10785 -23.98229 1.000 21.51959 ?  111 THR   A CA  1 
ATOM   861  C C   . THR   A 1 111 ? 3.17621   20.25491 -25.48671 1.000 16.77032 ?  111 THR   A C   1 
ATOM   862  O O   . THR   A 1 111 ? 3.88756   19.69655 -26.32894 1.000 15.91473 ?  111 THR   A O   1 
ATOM   863  C CB  . THR   A 1 111 ? 4.01282   21.40847 -23.45644 1.000 20.30485 ?  111 THR   A CB  1 
ATOM   864  O OG1 . THR   A 1 111 ? 5.30070   21.60407 -24.05746 1.000 17.45975 ?  111 THR   A OG1 1 
ATOM   865  C CG2 . THR   A 1 111 ? 4.10685   21.39686 -21.94910 1.000 18.68522 ?  111 THR   A CG2 1 
ATOM   866  N N   . PHE   A 1 112 ? 2.19627   21.08556 -25.80692 1.000 15.54645 ?  112 PHE   A N   1 
ATOM   867  C CA  . PHE   A 1 112 ? 1.88801   21.42974 -27.19054 1.000 17.15310 ?  112 PHE   A CA  1 
ATOM   868  C C   . PHE   A 1 112 ? 1.06780   22.71111 -27.21632 1.000 17.21573 ?  112 PHE   A C   1 
ATOM   869  O O   . PHE   A 1 112 ? 0.49025   23.11611 -26.20953 1.000 17.33687 ?  112 PHE   A O   1 
ATOM   870  C CB  . PHE   A 1 112 ? 1.14309   20.29349 -27.91410 1.000 15.12477 ?  112 PHE   A CB  1 
ATOM   871  C CG  . PHE   A 1 112 ? -0.08511  19.79057 -27.17212 1.000 17.01613 ?  112 PHE   A CG  1 
ATOM   872  C CD1 . PHE   A 1 112 ? 0.03245   18.83977 -26.17949 1.000 16.42988 ?  112 PHE   A CD1 1 
ATOM   873  C CD2 . PHE   A 1 112 ? -1.34090  20.25586 -27.48378 1.000 17.43794 ?  112 PHE   A CD2 1 
ATOM   874  C CE1 . PHE   A 1 112 ? -1.09505  18.36348 -25.51182 1.000 18.42079 ?  112 PHE   A CE1 1 
ATOM   875  C CE2 . PHE   A 1 112 ? -2.46949  19.79634 -26.80548 1.000 19.28123 ?  112 PHE   A CE2 1 
ATOM   876  C CZ  . PHE   A 1 112 ? -2.34550  18.84251 -25.82855 1.000 17.34506 ?  112 PHE   A CZ  1 
ATOM   877  N N   . SER   A 1 113 ? 1.00160   23.34232 -28.38881 1.000 13.28929 ?  113 SER   A N   1 
ATOM   878  C CA  . SER   A 1 113 ? 0.10201   24.46757 -28.58133 1.000 16.19136 ?  113 SER   A CA  1 
ATOM   879  C C   . SER   A 1 113 ? -1.23615  23.98646 -29.13580 1.000 17.81825 ?  113 SER   A C   1 
ATOM   880  O O   . SER   A 1 113 ? -1.29903  23.06475 -29.95018 1.000 16.42701 ?  113 SER   A O   1 
ATOM   881  C CB  . SER   A 1 113 ? 0.70853   25.50366 -29.52984 1.000 14.81830 ?  113 SER   A CB  1 
ATOM   882  O OG  . SER   A 1 113 ? 1.96304   25.93894 -29.06569 1.000 15.38388 ?  113 SER   A OG  1 
ATOM   883  N N   . VAL   A 1 114 ? -2.30183  24.62337 -28.68648 1.000 15.49796 ?  114 VAL   A N   1 
ATOM   884  C CA  . VAL   A 1 114 ? -3.63882  24.39526 -29.18242 1.000 16.18994 ?  114 VAL   A CA  1 
ATOM   885  C C   . VAL   A 1 114 ? -4.03472  25.64263 -29.93686 1.000 15.80376 ?  114 VAL   A C   1 
ATOM   886  O O   . VAL   A 1 114 ? -3.89488  26.76195 -29.41474 1.000 17.93759 ?  114 VAL   A O   1 
ATOM   887  C CB  . VAL   A 1 114 ? -4.63497  24.10462 -28.04888 1.000 17.74543 ?  114 VAL   A CB  1 
ATOM   888  C CG1 . VAL   A 1 114 ? -6.09021  24.19690 -28.59512 1.000 12.39037 ?  114 VAL   A CG1 1 
ATOM   889  C CG2 . VAL   A 1 114 ? -4.35686  22.75827 -27.43806 1.000 12.88712 ?  114 VAL   A CG2 1 
ATOM   890  N N   . LEU   A 1 115 ? -4.48278  25.45319 -31.17129 1.000 13.53105 ?  115 LEU   A N   1 
ATOM   891  C CA  . LEU   A 1 115 ? -5.08915  26.52981 -31.95401 1.000 13.91596 ?  115 LEU   A CA  1 
ATOM   892  C C   . LEU   A 1 115 ? -6.60395  26.32651 -31.86915 1.000 15.27171 ?  115 LEU   A C   1 
ATOM   893  O O   . LEU   A 1 115 ? -7.16745  25.47916 -32.56486 1.000 12.81336 ?  115 LEU   A O   1 
ATOM   894  C CB  . LEU   A 1 115 ? -4.58542  26.53069 -33.40290 1.000 12.20497 ?  115 LEU   A CB  1 
ATOM   895  C CG  . LEU   A 1 115 ? -5.31588  27.53836 -34.31204 1.000 12.28498 ?  115 LEU   A CG  1 
ATOM   896  C CD1 . LEU   A 1 115 ? -5.10001  28.96357 -33.82804 1.000 12.32277 ?  115 LEU   A CD1 1 
ATOM   897  C CD2 . LEU   A 1 115 ? -4.88246  27.40561 -35.75921 1.000 15.76663 ?  115 LEU   A CD2 1 
ATOM   898  N N   . ALA   A 1 116 ? -7.25348  27.08948 -30.99308 1.000 13.77688 ?  116 ALA   A N   1 
ATOM   899  C CA  . ALA   A 1 116 ? -8.68894  26.96891 -30.79925 1.000 15.27273 ?  116 ALA   A CA  1 
ATOM   900  C C   . ALA   A 1 116 ? -9.42847  27.66845 -31.92496 1.000 14.95805 ?  116 ALA   A C   1 
ATOM   901  O O   . ALA   A 1 116 ? -9.15817  28.84393 -32.22864 1.000 18.77736 ?  116 ALA   A O   1 
ATOM   902  C CB  . ALA   A 1 116 ? -9.09596  27.55809 -29.44797 1.000 13.48841 ?  116 ALA   A CB  1 
ATOM   903  N N   . CYS   A 1 117 ? -10.40040 26.94733 -32.49011 1.000 12.87124 ?  117 CYS   A N   1 
ATOM   904  C CA  . CYS   A 1 117 ? -11.10578 27.33016 -33.69954 1.000 14.53923 ?  117 CYS   A CA  1 
ATOM   905  C C   . CYS   A 1 117 ? -12.60647 27.17265 -33.51600 1.000 16.51250 ?  117 CYS   A C   1 
ATOM   906  O O   . CYS   A 1 117 ? -13.05566 26.30711 -32.76555 1.000 15.96706 ?  117 CYS   A O   1 
ATOM   907  C CB  . CYS   A 1 117 ? -10.67962 26.46982 -34.87965 1.000 15.87411 ?  117 CYS   A CB  1 
ATOM   908  S SG  . CYS   A 1 117 ? -9.00959  26.78936 -35.42365 1.000 22.94960 ?  117 CYS   A SG  1 
ATOM   909  N N   . TYR   A 1 118 ? -13.37384 28.01068 -34.22802 1.000 18.10601 ?  118 TYR   A N   1 
ATOM   910  C CA  . TYR   A 1 118 ? -14.82874 27.88252 -34.31685 1.000 22.25288 ?  118 TYR   A CA  1 
ATOM   911  C C   . TYR   A 1 118 ? -15.20271 28.09932 -35.76840 1.000 18.68778 ?  118 TYR   A C   1 
ATOM   912  O O   . TYR   A 1 118 ? -14.69755 29.03033 -36.40317 1.000 18.30876 ?  118 TYR   A O   1 
ATOM   913  C CB  . TYR   A 1 118 ? -15.54576 28.89024 -33.39754 1.000 21.42531 ?  118 TYR   A CB  1 
ATOM   914  C CG  . TYR   A 1 118 ? -15.13574 28.63876 -31.98386 1.000 20.95538 ?  118 TYR   A CG  1 
ATOM   915  C CD1 . TYR   A 1 118 ? -15.77718 27.66114 -31.23248 1.000 21.33464 ?  118 TYR   A CD1 1 
ATOM   916  C CD2 . TYR   A 1 118 ? -14.04703 29.29234 -31.42310 1.000 21.73330 ?  118 TYR   A CD2 1 
ATOM   917  C CE1 . TYR   A 1 118 ? -15.37146 27.36018 -29.95113 1.000 20.05119 ?  118 TYR   A CE1 1 
ATOM   918  C CE2 . TYR   A 1 118 ? -13.63800 28.99758 -30.11951 1.000 19.31249 ?  118 TYR   A CE2 1 
ATOM   919  C CZ  . TYR   A 1 118 ? -14.30121 28.02464 -29.40296 1.000 19.01486 ?  118 TYR   A CZ  1 
ATOM   920  O OH  . TYR   A 1 118 ? -13.92141 27.70607 -28.11784 1.000 22.72679 ?  118 TYR   A OH  1 
ATOM   921  N N   . ASN   A 1 119 ? -16.04090 27.21375 -36.30391 1.000 17.51831 ?  119 ASN   A N   1 
ATOM   922  C CA  . ASN   A 1 119 ? -16.51007 27.33674 -37.68407 1.000 18.27637 ?  119 ASN   A CA  1 
ATOM   923  C C   . ASN   A 1 119 ? -15.36205 27.37020 -38.68098 1.000 20.93171 ?  119 ASN   A C   1 
ATOM   924  O O   . ASN   A 1 119 ? -15.44378 28.04251 -39.71303 1.000 18.50850 ?  119 ASN   A O   1 
ATOM   925  C CB  . ASN   A 1 119 ? -17.38564 28.57397 -37.85798 1.000 19.12728 ?  119 ASN   A CB  1 
ATOM   926  C CG  . ASN   A 1 119 ? -18.55473 28.56029 -36.92521 1.000 29.46017 ?  119 ASN   A CG  1 
ATOM   927  O OD1 . ASN   A 1 119 ? -19.48138 27.76621 -37.10141 1.000 34.83082 ?  119 ASN   A OD1 1 
ATOM   928  N ND2 . ASN   A 1 119 ? -18.49297 29.38042 -35.88283 1.000 25.02495 ?  119 ASN   A ND2 1 
ATOM   929  N N   . GLY   A 1 120 ? -14.29734 26.63178 -38.38774 1.000 19.13866 ?  120 GLY   A N   1 
ATOM   930  C CA  . GLY   A 1 120 ? -13.16909 26.56445 -39.28465 1.000 18.78808 ?  120 GLY   A CA  1 
ATOM   931  C C   . GLY   A 1 120 ? -12.24522 27.75394 -39.23494 1.000 21.20833 ?  120 GLY   A C   1 
ATOM   932  O O   . GLY   A 1 120 ? -11.28814 27.79661 -40.01641 1.000 21.87398 ?  120 GLY   A O   1 
ATOM   933  N N   . SER   A 1 121 ? -12.50561 28.73983 -38.34460 1.000 20.40418 ?  121 SER   A N   1 
ATOM   934  C CA  . SER   A 1 121 ? -11.70859 29.95418 -38.27441 1.000 21.59118 ?  121 SER   A CA  1 
ATOM   935  C C   . SER   A 1 121 ? -10.99930 30.02704 -36.93593 1.000 24.64343 ?  121 SER   A C   1 
ATOM   936  O O   . SER   A 1 121 ? -11.58704 29.66587 -35.90684 1.000 21.01437 ?  121 SER   A O   1 
ATOM   937  C CB  . SER   A 1 121 ? -12.55412 31.22609 -38.43003 1.000 21.25869 ?  121 SER   A CB  1 
ATOM   938  O OG  . SER   A 1 121 ? -13.20327 31.25614 -39.66746 1.000 29.29442 ?  121 SER   A OG  1 
ATOM   939  N N   . PRO   A 1 122 ? -9.76903  30.54130 -36.90918 1.000 25.90209 ?  122 PRO   A N   1 
ATOM   940  C CA  . PRO   A 1 122 ? -8.98871  30.51433 -35.67057 1.000 19.79418 ?  122 PRO   A CA  1 
ATOM   941  C C   . PRO   A 1 122 ? -9.45015  31.58872 -34.71081 1.000 23.63891 ?  122 PRO   A C   1 
ATOM   942  O O   . PRO   A 1 122 ? -9.72827  32.72636 -35.09870 1.000 26.30839 ?  122 PRO   A O   1 
ATOM   943  C CB  . PRO   A 1 122 ? -7.55525  30.77603 -36.14762 1.000 24.41215 ?  122 PRO   A CB  1 
ATOM   944  C CG  . PRO   A 1 122 ? -7.61053  30.55957 -37.67162 1.000 34.30377 ?  122 PRO   A CG  1 
ATOM   945  C CD  . PRO   A 1 122 ? -8.97324  31.06508 -38.02288 1.000 24.92380 ?  122 PRO   A CD  1 
ATOM   946  N N   . SER   A 1 123 ? -9.52216  31.22100 -33.44322 1.000 19.72961 ?  123 SER   A N   1 
ATOM   947  C CA  . SER   A 1 123 ? -9.88810  32.15243 -32.39076 1.000 23.54062 ?  123 SER   A CA  1 
ATOM   948  C C   . SER   A 1 123 ? -8.70104  32.51353 -31.52370 1.000 22.72266 ?  123 SER   A C   1 
ATOM   949  O O   . SER   A 1 123 ? -8.52525  33.68688 -31.18077 1.000 22.81416 ?  123 SER   A O   1 
ATOM   950  C CB  . SER   A 1 123 ? -11.00733 31.55614 -31.52146 1.000 21.55292 ?  123 SER   A CB  1 
ATOM   951  O OG  . SER   A 1 123 ? -11.27101 32.33050 -30.36283 1.000 29.11518 ?  123 SER   A OG  1 
ATOM   952  N N   . GLY   A 1 124 ? -7.87256  31.53725 -31.18364 1.000 16.62352 ?  124 GLY   A N   1 
ATOM   953  C CA  . GLY   A 1 124 ? -6.75482  31.88125 -30.31043 1.000 18.13750 ?  124 GLY   A CA  1 
ATOM   954  C C   . GLY   A 1 124 ? -5.78666  30.72931 -30.21486 1.000 17.33020 ?  124 GLY   A C   1 
ATOM   955  O O   . GLY   A 1 124 ? -6.05685  29.64155 -30.72366 1.000 20.96261 ?  124 GLY   A O   1 
ATOM   956  N N   . VAL   A 1 125 ? -4.64712  30.98116 -29.56327 1.000 14.75856 ?  125 VAL   A N   1 
ATOM   957  C CA  . VAL   A 1 125 ? -3.59969  29.97270 -29.42910 1.000 16.41763 ?  125 VAL   A CA  1 
ATOM   958  C C   . VAL   A 1 125 ? -3.06432  29.97675 -27.99895 1.000 16.33511 ?  125 VAL   A C   1 
ATOM   959  O O   . VAL   A 1 125 ? -2.84072  31.03425 -27.40323 1.000 20.93360 ?  125 VAL   A O   1 
ATOM   960  C CB  . VAL   A 1 125 ? -2.46560  30.20199 -30.46465 1.000 16.75397 ?  125 VAL   A CB  1 
ATOM   961  C CG1 . VAL   A 1 125 ? -1.78531  31.52122 -30.23142 1.000 17.36578 ?  125 VAL   A CG1 1 
ATOM   962  C CG2 . VAL   A 1 125 ? -1.45952  29.03881 -30.43706 1.000 15.15775 ?  125 VAL   A CG2 1 
ATOM   963  N N   . TYR   A 1 126 ? -2.87156  28.79235 -27.43688 1.000 12.96480 ?  126 TYR   A N   1 
ATOM   964  C CA  . TYR   A 1 126 ? -2.35248  28.71089 -26.07489 1.000 15.54079 ?  126 TYR   A CA  1 
ATOM   965  C C   . TYR   A 1 126 ? -1.64482  27.38196 -25.87920 1.000 17.30897 ?  126 TYR   A C   1 
ATOM   966  O O   . TYR   A 1 126 ? -1.86593  26.41491 -26.60728 1.000 16.14081 ?  126 TYR   A O   1 
ATOM   967  C CB  . TYR   A 1 126 ? -3.44941  28.87225 -25.00059 1.000 17.08805 ?  126 TYR   A CB  1 
ATOM   968  C CG  . TYR   A 1 126 ? -4.65182  27.96370 -25.17615 1.000 21.07232 ?  126 TYR   A CG  1 
ATOM   969  C CD1 . TYR   A 1 126 ? -4.63891  26.65188 -24.70021 1.000 19.12686 ?  126 TYR   A CD1 1 
ATOM   970  C CD2 . TYR   A 1 126 ? -5.80781  28.42389 -25.79563 1.000 22.96418 ?  126 TYR   A CD2 1 
ATOM   971  C CE1 . TYR   A 1 126 ? -5.73296  25.83001 -24.86099 1.000 19.14592 ?  126 TYR   A CE1 1 
ATOM   972  C CE2 . TYR   A 1 126 ? -6.91554  27.61060 -25.95738 1.000 21.37521 ?  126 TYR   A CE2 1 
ATOM   973  C CZ  . TYR   A 1 126 ? -6.87019  26.31688 -25.48638 1.000 25.43414 ?  126 TYR   A CZ  1 
ATOM   974  O OH  . TYR   A 1 126 ? -7.96728  25.51119 -25.64437 1.000 24.79426 ?  126 TYR   A OH  1 
ATOM   975  N N   . GLN   A 1 127 ? -0.80269  27.33670 -24.87017 1.000 16.58963 ?  127 GLN   A N   1 
ATOM   976  C CA  . GLN   A 1 127 ? 0.02553   26.17701 -24.60485 1.000 16.36867 ?  127 GLN   A CA  1 
ATOM   977  C C   . GLN   A 1 127 ? -0.64229  25.29488 -23.55480 1.000 22.35668 ?  127 GLN   A C   1 
ATOM   978  O O   . GLN   A 1 127 ? -1.25348  25.79391 -22.60740 1.000 20.65099 ?  127 GLN   A O   1 
ATOM   979  C CB  . GLN   A 1 127 ? 1.39616   26.66478 -24.13323 1.000 19.26485 ?  127 GLN   A CB  1 
ATOM   980  C CG  . GLN   A 1 127 ? 2.44438   25.61797 -23.97805 1.000 27.42475 ?  127 GLN   A CG  1 
ATOM   981  C CD  . GLN   A 1 127 ? 3.28493   25.41282 -25.22329 1.000 27.46797 ?  127 GLN   A CD  1 
ATOM   982  O OE1 . GLN   A 1 127 ? 2.83246   25.61293 -26.35482 1.000 22.23196 ?  127 GLN   A OE1 1 
ATOM   983  N NE2 . GLN   A 1 127 ? 4.51938   24.99383 -25.01654 1.000 31.43672 ?  127 GLN   A NE2 1 
ATOM   984  N N   . CYS   A 1 128 ? -0.51560  23.97831 -23.72541 1.000 19.85636 ?  128 CYS   A N   1 
ATOM   985  C CA  . CYS   A 1 128 ? -1.13940  22.97258 -22.87388 1.000 18.05554 ?  128 CYS   A CA  1 
ATOM   986  C C   . CYS   A 1 128 ? -0.13629  21.87060 -22.57564 1.000 20.18959 ?  128 CYS   A C   1 
ATOM   987  O O   . CYS   A 1 128 ? 0.79179   21.62462 -23.34821 1.000 20.92508 ?  128 CYS   A O   1 
ATOM   988  C CB  . CYS   A 1 128 ? -2.35728  22.32946 -23.55525 1.000 23.30757 ?  128 CYS   A CB  1 
ATOM   989  S SG  . CYS   A 1 128 ? -3.87824  23.25604 -23.48849 1.000 30.66401 ?  128 CYS   A SG  1 
ATOM   990  N N   . ALA   A 1 129 ? -0.34217  21.17225 -21.46632 1.000 20.63695 ?  129 ALA   A N   1 
ATOM   991  C CA  . ALA   A 1 129 ? 0.46482   20.00264 -21.13665 1.000 19.93445 ?  129 ALA   A CA  1 
ATOM   992  C C   . ALA   A 1 129 ? -0.43698  18.78279 -21.08825 1.000 18.24867 ?  129 ALA   A C   1 
ATOM   993  O O   . ALA   A 1 129 ? -1.56083  18.86460 -20.58404 1.000 18.26296 ?  129 ALA   A O   1 
ATOM   994  C CB  . ALA   A 1 129 ? 1.17278   20.17086 -19.79298 1.000 19.57186 ?  129 ALA   A CB  1 
ATOM   995  N N   . MET   A 1 130 ? 0.03600   17.65390 -21.59999 1.000 14.03564 ?  130 MET   A N   1 
ATOM   996  C CA  . MET   A 1 130 ? -0.74575  16.43338 -21.43760 1.000 18.90342 ?  130 MET   A CA  1 
ATOM   997  C C   . MET   A 1 130 ? -0.53351  15.94763 -20.01971 1.000 16.23003 ?  130 MET   A C   1 
ATOM   998  O O   . MET   A 1 130 ? 0.59947   15.61918 -19.64796 1.000 19.65025 ?  130 MET   A O   1 
ATOM   999  C CB  . MET   A 1 130 ? -0.33842  15.36755 -22.44417 1.000 18.35663 ?  130 MET   A CB  1 
ATOM   1000 C CG  . MET   A 1 130 ? -1.06308  14.03317 -22.22001 1.000 15.92777 ?  130 MET   A CG  1 
ATOM   1001 S SD  . MET   A 1 130 ? -2.81083  14.15723 -22.59532 1.000 22.32709 ?  130 MET   A SD  1 
ATOM   1002 C CE  . MET   A 1 130 ? -2.75150  14.71995 -24.29726 1.000 15.28890 ?  130 MET   A CE  1 
ATOM   1003 N N   . ARG   A 1 131 ? -1.59251  15.96249 -19.20875 1.000 14.39682 ?  131 ARG   A N   1 
ATOM   1004 C CA  . ARG   A 1 131 ? -1.44707  15.60670 -17.79943 1.000 20.34549 ?  131 ARG   A CA  1 
ATOM   1005 C C   . ARG   A 1 131 ? -1.15847  14.11593 -17.64408 1.000 20.51548 ?  131 ARG   A C   1 
ATOM   1006 O O   . ARG   A 1 131 ? -1.43287  13.32161 -18.54822 1.000 17.38518 ?  131 ARG   A O   1 
ATOM   1007 C CB  . ARG   A 1 131 ? -2.70028  15.95898 -17.00612 1.000 16.46873 ?  131 ARG   A CB  1 
ATOM   1008 C CG  . ARG   A 1 131 ? -3.12313  17.44182 -17.05384 1.000 21.68562 ?  131 ARG   A CG  1 
ATOM   1009 C CD  . ARG   A 1 131 ? -2.05076  18.38960 -16.57843 1.000 20.63455 ?  131 ARG   A CD  1 
ATOM   1010 N NE  . ARG   A 1 131 ? -1.51848  17.99545 -15.27745 1.000 20.10718 ?  131 ARG   A NE  1 
ATOM   1011 C CZ  . ARG   A 1 131 ? -0.47724  18.57470 -14.69507 1.000 22.00378 ?  131 ARG   A CZ  1 
ATOM   1012 N NH1 . ARG   A 1 131 ? 0.14939   19.60119 -15.26102 1.000 19.85357 ?  131 ARG   A NH1 1 
ATOM   1013 N NH2 . ARG   A 1 131 ? -0.05759  18.12149 -13.51713 1.000 18.75385 ?  131 ARG   A NH2 1 
ATOM   1014 N N   . PRO   A 1 132 ? -0.58559  13.71351 -16.50450 1.000 17.82384 ?  132 PRO   A N   1 
ATOM   1015 C CA  . PRO   A 1 132 ? -0.39127  12.27629 -16.25311 1.000 23.06097 ?  132 PRO   A CA  1 
ATOM   1016 C C   . PRO   A 1 132 ? -1.68061  11.47302 -16.26381 1.000 22.86599 ?  132 PRO   A C   1 
ATOM   1017 O O   . PRO   A 1 132 ? -1.62755  10.26394 -16.52540 1.000 22.27873 ?  132 PRO   A O   1 
ATOM   1018 C CB  . PRO   A 1 132 ? 0.28110   12.24879 -14.87215 1.000 16.68670 ?  132 PRO   A CB  1 
ATOM   1019 C CG  . PRO   A 1 132 ? 1.02462   13.54220 -14.82558 1.000 24.61304 ?  132 PRO   A CG  1 
ATOM   1020 C CD  . PRO   A 1 132 ? 0.14176   14.54405 -15.53077 1.000 18.80005 ?  132 PRO   A CD  1 
ATOM   1021 N N   . ASN   A 1 133 ? -2.82913  12.09594 -15.98960 1.000 21.95501 ?  133 ASN   A N   1 
ATOM   1022 C CA  . ASN   A 1 133 ? -4.12058  11.42637 -16.08616 1.000 23.43681 ?  133 ASN   A CA  1 
ATOM   1023 C C   . ASN   A 1 133 ? -4.74810  11.57690 -17.46171 1.000 24.24099 ?  133 ASN   A C   1 
ATOM   1024 O O   . ASN   A 1 133 ? -5.93882  11.28059 -17.63004 1.000 18.10864 ?  133 ASN   A O   1 
ATOM   1025 C CB  . ASN   A 1 133 ? -5.07927  11.94315 -15.00281 1.000 25.50596 ?  133 ASN   A CB  1 
ATOM   1026 C CG  . ASN   A 1 133 ? -5.50128  13.38909 -15.21013 1.000 29.03846 ?  133 ASN   A CG  1 
ATOM   1027 O OD1 . ASN   A 1 133 ? -5.06691  14.06819 -16.15152 1.000 22.60005 ?  133 ASN   A OD1 1 
ATOM   1028 N ND2 . ASN   A 1 133 ? -6.38210  13.86656 -14.32752 1.000 23.85165 ?  133 ASN   A ND2 1 
ATOM   1029 N N   . PHE   A 1 134 ? -3.97217  12.05987 -18.43476 1.000 21.41891 ?  134 PHE   A N   1 
ATOM   1030 C CA  . PHE   A 1 134 ? -4.36322  12.13475 -19.84401 1.000 18.91691 ?  134 PHE   A CA  1 
ATOM   1031 C C   . PHE   A 1 134 ? -5.46912  13.16795 -20.11834 1.000 21.68526 ?  134 PHE   A C   1 
ATOM   1032 O O   . PHE   A 1 134 ? -6.23540  13.03566 -21.08192 1.000 22.49653 ?  134 PHE   A O   1 
ATOM   1033 C CB  . PHE   A 1 134 ? -4.75143  10.74681 -20.36814 1.000 19.95279 ?  134 PHE   A CB  1 
ATOM   1034 C CG  . PHE   A 1 134 ? -3.60315  9.78596  -20.40248 1.000 26.73863 ?  134 PHE   A CG  1 
ATOM   1035 C CD1 . PHE   A 1 134 ? -2.63781  9.87949  -21.39639 1.000 29.76285 ?  134 PHE   A CD1 1 
ATOM   1036 C CD2 . PHE   A 1 134 ? -3.45711  8.81844  -19.42043 1.000 26.33297 ?  134 PHE   A CD2 1 
ATOM   1037 C CE1 . PHE   A 1 134 ? -1.55382  8.99473  -21.41702 1.000 40.05278 ?  134 PHE   A CE1 1 
ATOM   1038 C CE2 . PHE   A 1 134 ? -2.38128  7.94380  -19.43514 1.000 29.55846 ?  134 PHE   A CE2 1 
ATOM   1039 C CZ  . PHE   A 1 134 ? -1.43078  8.02884  -20.42880 1.000 31.04308 ?  134 PHE   A CZ  1 
ATOM   1040 N N   . THR   A 1 135 ? -5.52818  14.24230 -19.33768 1.000 19.32959 ?  135 THR   A N   1 
ATOM   1041 C CA  . THR   A 1 135 ? -6.41454  15.35464 -19.64056 1.000 18.71935 ?  135 THR   A CA  1 
ATOM   1042 C C   . THR   A 1 135 ? -5.57742  16.59211 -19.93693 1.000 21.18709 ?  135 THR   A C   1 
ATOM   1043 O O   . THR   A 1 135 ? -4.35971  16.59698 -19.72673 1.000 21.50393 ?  135 THR   A O   1 
ATOM   1044 C CB  . THR   A 1 135 ? -7.37399  15.61413 -18.47405 1.000 20.36888 ?  135 THR   A CB  1 
ATOM   1045 O OG1 . THR   A 1 135 ? -6.62627  15.99042 -17.31232 1.000 21.27111 ?  135 THR   A OG1 1 
ATOM   1046 C CG2 . THR   A 1 135 ? -8.19150  14.35445 -18.16242 1.000 17.46825 ?  135 THR   A CG2 1 
ATOM   1047 N N   . ILE   A 1 136 ? -6.23147  17.65913 -20.41776 1.000 17.98665 ?  136 ILE   A N   1 
ATOM   1048 C CA  . ILE   A 1 136 ? -5.55373  18.93979 -20.60715 1.000 23.52993 ?  136 ILE   A CA  1 
ATOM   1049 C C   . ILE   A 1 136 ? -6.42568  20.06180 -20.05208 1.000 22.09302 ?  136 ILE   A C   1 
ATOM   1050 O O   . ILE   A 1 136 ? -7.65473  19.95109 -19.99009 1.000 19.48052 ?  136 ILE   A O   1 
ATOM   1051 C CB  . ILE   A 1 136 ? -5.18951  19.23033 -22.09183 1.000 25.05319 ?  136 ILE   A CB  1 
ATOM   1052 C CG1 . ILE   A 1 136 ? -6.43879  19.43972 -22.94566 1.000 16.91310 ?  136 ILE   A CG1 1 
ATOM   1053 C CG2 . ILE   A 1 136 ? -4.29903  18.13354 -22.67843 1.000 19.76407 ?  136 ILE   A CG2 1 
ATOM   1054 C CD1 . ILE   A 1 136 ? -6.14799  19.90285 -24.35641 1.000 20.08495 ?  136 ILE   A CD1 1 
ATOM   1055 N N   . LYS   A 1 137 ? -5.77498  21.15445 -19.63588 1.000 18.90657 ?  137 LYS   A N   1 
ATOM   1056 C CA  . LYS   A 1 137 ? -6.47923  22.31032 -19.07969 1.000 24.87481 ?  137 LYS   A CA  1 
ATOM   1057 C C   . LYS   A 1 137 ? -6.58211  23.35220 -20.18891 1.000 27.76991 ?  137 LYS   A C   1 
ATOM   1058 O O   . LYS   A 1 137 ? -5.76539  24.26972 -20.30841 1.000 23.83333 ?  137 LYS   A O   1 
ATOM   1059 C CB  . LYS   A 1 137 ? -5.74864  22.87039 -17.86290 1.000 23.95534 ?  137 LYS   A CB  1 
ATOM   1060 C CG  . LYS   A 1 137 ? -5.01535  21.85148 -17.01886 1.000 30.92357 ?  137 LYS   A CG  1 
ATOM   1061 C CD  . LYS   A 1 137 ? -5.92022  21.25244 -15.95509 1.000 39.55698 ?  137 LYS   A CD  1 
ATOM   1062 C CE  . LYS   A 1 137 ? -5.14664  20.96001 -14.66411 1.000 39.37672 ?  137 LYS   A CE  1 
ATOM   1063 N NZ  . LYS   A 1 137 ? -5.63356  19.71557 -13.97039 1.000 42.64029 ?  137 LYS   A NZ  1 
ATOM   1064 N N   . GLY   A 1 138 ? -7.61532  23.20332 -21.01363 1.000 22.73239 ?  138 GLY   A N   1 
ATOM   1065 C CA  . GLY   A 1 138 ? -7.80849  24.05262 -22.16380 1.000 23.00359 ?  138 GLY   A CA  1 
ATOM   1066 C C   . GLY   A 1 138 ? -8.86894  25.11062 -21.93223 1.000 22.67744 ?  138 GLY   A C   1 
ATOM   1067 O O   . GLY   A 1 138 ? -9.30584  25.37261 -20.81295 1.000 19.98801 ?  138 GLY   A O   1 
ATOM   1068 N N   . SER   A 1 139 ? -9.27593  25.73284 -23.02848 1.000 23.37899 ?  139 SER   A N   1 
ATOM   1069 C CA  . SER   A 1 139 ? -10.38544 26.67773 -23.05619 1.000 23.98534 ?  139 SER   A CA  1 
ATOM   1070 C C   . SER   A 1 139 ? -11.11483 26.38008 -24.35714 1.000 21.12738 ?  139 SER   A C   1 
ATOM   1071 O O   . SER   A 1 139 ? -10.61995 26.71330 -25.43998 1.000 21.03476 ?  139 SER   A O   1 
ATOM   1072 C CB  . SER   A 1 139 ? -9.89462  28.12462 -23.00274 1.000 23.21407 ?  139 SER   A CB  1 
ATOM   1073 O OG  . SER   A 1 139 ? -10.92026 29.03468 -23.36342 1.000 23.67912 ?  139 SER   A OG  1 
ATOM   1074 N N   . PHE   A 1 140 ? -12.27098 25.74359 -24.24561 1.000 24.51635 ?  140 PHE   A N   1 
ATOM   1075 C CA  . PHE   A 1 140 ? -13.04210 25.25785 -25.38359 1.000 20.35888 ?  140 PHE   A CA  1 
ATOM   1076 C C   . PHE   A 1 140 ? -14.51969 25.53118 -25.12440 1.000 22.19689 ?  140 PHE   A C   1 
ATOM   1077 O O   . PHE   A 1 140 ? -15.01137 25.31483 -24.01548 1.000 26.13422 ?  140 PHE   A O   1 
ATOM   1078 C CB  . PHE   A 1 140 ? -12.83164 23.74455 -25.60641 1.000 18.70724 ?  140 PHE   A CB  1 
ATOM   1079 C CG  . PHE   A 1 140 ? -11.42282 23.35496 -26.01483 1.000 19.27809 ?  140 PHE   A CG  1 
ATOM   1080 C CD1 . PHE   A 1 140 ? -10.94263 23.64605 -27.28891 1.000 19.23744 ?  140 PHE   A CD1 1 
ATOM   1081 C CD2 . PHE   A 1 140 ? -10.59126 22.67254 -25.13339 1.000 20.94991 ?  140 PHE   A CD2 1 
ATOM   1082 C CE1 . PHE   A 1 140 ? -9.64643  23.27681 -27.66936 1.000 20.94869 ?  140 PHE   A CE1 1 
ATOM   1083 C CE2 . PHE   A 1 140 ? -9.29974  22.29792 -25.49904 1.000 19.19861 ?  140 PHE   A CE2 1 
ATOM   1084 C CZ  . PHE   A 1 140 ? -8.82895  22.59795 -26.78215 1.000 18.81186 ?  140 PHE   A CZ  1 
ATOM   1085 N N   . LEU   A 1 141 ? -15.21940 26.01685 -26.13598 1.000 19.90549 ?  141 LEU   A N   1 
ATOM   1086 C CA  . LEU   A 1 141 ? -16.66149 26.20393 -26.08011 1.000 20.75260 ?  141 LEU   A CA  1 
ATOM   1087 C C   . LEU   A 1 141 ? -17.30715 25.22858 -27.06744 1.000 22.20111 ?  141 LEU   A C   1 
ATOM   1088 O O   . LEU   A 1 141 ? -16.62711 24.37547 -27.66324 1.000 18.69391 ?  141 LEU   A O   1 
ATOM   1089 C CB  . LEU   A 1 141 ? -17.02656 27.65922 -26.37391 1.000 21.13529 ?  141 LEU   A CB  1 
ATOM   1090 C CG  . LEU   A 1 141 ? -16.30785 28.70253 -25.50828 1.000 27.22389 ?  141 LEU   A CG  1 
ATOM   1091 C CD1 . LEU   A 1 141 ? -16.56339 30.10353 -26.03118 1.000 31.55497 ?  141 LEU   A CD1 1 
ATOM   1092 C CD2 . LEU   A 1 141 ? -16.77263 28.59986 -24.06034 1.000 29.01185 ?  141 LEU   A CD2 1 
ATOM   1093 N N   . ASN   A 1 142 ? -18.62872 25.33681 -27.21749 1.000 19.14875 ?  142 ASN   A N   1 
ATOM   1094 C CA  . ASN   A 1 142 ? -19.31638 24.57842 -28.25362 1.000 20.22393 ?  142 ASN   A CA  1 
ATOM   1095 C C   . ASN   A 1 142 ? -18.75018 24.95604 -29.60924 1.000 18.34549 ?  142 ASN   A C   1 
ATOM   1096 O O   . ASN   A 1 142 ? -18.45735 26.12540 -29.86554 1.000 17.05107 ?  142 ASN   A O   1 
ATOM   1097 C CB  . ASN   A 1 142 ? -20.81933 24.86623 -28.26639 1.000 25.35616 ?  142 ASN   A CB  1 
ATOM   1098 C CG  . ASN   A 1 142 ? -21.54677 24.31829 -27.05345 1.000 27.76188 ?  142 ASN   A CG  1 
ATOM   1099 O OD1 . ASN   A 1 142 ? -21.39221 23.15373 -26.66698 1.000 30.97118 ?  142 ASN   A OD1 1 
ATOM   1100 N ND2 . ASN   A 1 142 ? -22.36664 25.16440 -26.45499 1.000 33.70720 ?  142 ASN   A ND2 1 
ATOM   1101 N N   . GLY   A 1 143 ? -18.63322 23.96380 -30.49091 1.000 19.89153 ?  143 GLY   A N   1 
ATOM   1102 C CA  . GLY   A 1 143 ? -18.08519 24.17284 -31.81579 1.000 21.02195 ?  143 GLY   A CA  1 
ATOM   1103 C C   . GLY   A 1 143 ? -16.57214 24.10857 -31.91869 1.000 18.34934 ?  143 GLY   A C   1 
ATOM   1104 O O   . GLY   A 1 143 ? -16.04665 24.14310 -33.04058 1.000 19.99575 ?  143 GLY   A O   1 
ATOM   1105 N N   . SER   A 1 144 ? -15.85730 24.01250 -30.79428 1.000 17.86102 ?  144 SER   A N   1 
ATOM   1106 C CA  . SER   A 1 144 ? -14.39407 23.97041 -30.79177 1.000 20.32361 ?  144 SER   A CA  1 
ATOM   1107 C C   . SER   A 1 144 ? -13.81730 22.61940 -31.20135 1.000 14.19598 ?  144 SER   A C   1 
ATOM   1108 O O   . SER   A 1 144 ? -12.61039 22.52824 -31.44529 1.000 13.78627 ?  144 SER   A O   1 
ATOM   1109 C CB  . SER   A 1 144 ? -13.86260 24.31379 -29.39353 1.000 16.68947 ?  144 SER   A CB  1 
ATOM   1110 O OG  . SER   A 1 144 ? -14.27974 23.34226 -28.43029 1.000 16.88156 ?  144 SER   A OG  1 
ATOM   1111 N N   . CYS   A 1 145 ? -14.62847 21.56829 -31.24298 1.000 16.33507 ?  145 CYS   A N   1 
ATOM   1112 C CA  . CYS   A 1 145 ? -14.11892 20.24216 -31.54990 1.000 14.30084 ?  145 CYS   A CA  1 
ATOM   1113 C C   . CYS   A 1 145 ? -13.50519 20.23187 -32.93685 1.000 15.34416 ?  145 CYS   A C   1 
ATOM   1114 O O   . CYS   A 1 145 ? -13.94817 20.94830 -33.84088 1.000 18.08788 ?  145 CYS   A O   1 
ATOM   1115 C CB  . CYS   A 1 145 ? -15.24286 19.21032 -31.42898 1.000 18.86767 ?  145 CYS   A CB  1 
ATOM   1116 S SG  . CYS   A 1 145 ? -15.53741 18.79365 -29.70090 1.000 20.76022 ?  145 CYS   A SG  1 
ATOM   1117 N N   . GLY   A 1 146 ? -12.44177 19.44566 -33.08588 1.000 18.78102 ?  146 GLY   A N   1 
ATOM   1118 C CA  . GLY   A 1 146 ? -11.63443 19.47999 -34.28068 1.000 18.35960 ?  146 GLY   A CA  1 
ATOM   1119 C C   . GLY   A 1 146 ? -10.47569 20.44749 -34.22189 1.000 16.25311 ?  146 GLY   A C   1 
ATOM   1120 O O   . GLY   A 1 146 ? -9.56398  20.33681 -35.03621 1.000 17.63239 ?  146 GLY   A O   1 
ATOM   1121 N N   . SER   A 1 147 ? -10.50158 21.40720 -33.29582 1.000 17.22585 ?  147 SER   A N   1 
ATOM   1122 C CA  . SER   A 1 147 ? -9.30328  22.15116 -32.93968 1.000 18.51475 ?  147 SER   A CA  1 
ATOM   1123 C C   . SER   A 1 147 ? -8.17540  21.17344 -32.63326 1.000 18.75615 ?  147 SER   A C   1 
ATOM   1124 O O   . SER   A 1 147 ? -8.40547  20.11210 -32.02837 1.000 16.79603 ?  147 SER   A O   1 
ATOM   1125 C CB  . SER   A 1 147 ? -9.57986  23.05313 -31.72443 1.000 13.22688 ?  147 SER   A CB  1 
ATOM   1126 O OG  . SER   A 1 147 ? -10.49032 24.09492 -32.06136 1.000 11.80619 ?  147 SER   A OG  1 
ATOM   1127 N N   . VAL   A 1 148 ? -6.95481  21.51808 -33.07234 1.000 15.92897 ?  148 VAL   A N   1 
ATOM   1128 C CA  . VAL   A 1 148 ? -5.82900  20.60748 -32.90537 1.000 17.87978 ?  148 VAL   A CA  1 
ATOM   1129 C C   . VAL   A 1 148 ? -4.73308  21.23281 -32.04688 1.000 17.22859 ?  148 VAL   A C   1 
ATOM   1130 O O   . VAL   A 1 148 ? -4.56736  22.46147 -31.95868 1.000 17.51706 ?  148 VAL   A O   1 
ATOM   1131 C CB  . VAL   A 1 148 ? -5.23441  20.14870 -34.25365 1.000 15.14495 ?  148 VAL   A CB  1 
ATOM   1132 C CG1 . VAL   A 1 148 ? -6.26288  19.36146 -35.02491 1.000 16.90922 ?  148 VAL   A CG1 1 
ATOM   1133 C CG2 . VAL   A 1 148 ? -4.73892  21.35123 -35.04403 1.000 16.66886 ?  148 VAL   A CG2 1 
ATOM   1134 N N   . GLY   A 1 149 ? -3.96185  20.34316 -31.43028 1.000 14.85725 ?  149 GLY   A N   1 
ATOM   1135 C CA  . GLY   A 1 149 ? -2.71578  20.69595 -30.77714 1.000 16.69022 ?  149 GLY   A CA  1 
ATOM   1136 C C   . GLY   A 1 149 ? -1.53610  20.12791 -31.54869 1.000 18.03370 ?  149 GLY   A C   1 
ATOM   1137 O O   . GLY   A 1 149 ? -1.65290  19.11355 -32.24466 1.000 15.66494 ?  149 GLY   A O   1 
ATOM   1138 N N   . PHE   A 1 150 ? -0.38660  20.78605 -31.40629 1.000 17.73242 ?  150 PHE   A N   1 
ATOM   1139 C CA  . PHE   A 1 150 ? 0.75422   20.53073 -32.27434 1.000 15.72991 ?  150 PHE   A CA  1 
ATOM   1140 C C   . PHE   A 1 150 ? 2.01810   21.08692 -31.62700 1.000 18.71359 ?  150 PHE   A C   1 
ATOM   1141 O O   . PHE   A 1 150 ? 1.96661   21.92709 -30.72193 1.000 17.81426 ?  150 PHE   A O   1 
ATOM   1142 C CB  . PHE   A 1 150 ? 0.55245   21.17485 -33.65647 1.000 13.78449 ?  150 PHE   A CB  1 
ATOM   1143 C CG  . PHE   A 1 150 ? 0.43617   22.68045 -33.59147 1.000 20.28666 ?  150 PHE   A CG  1 
ATOM   1144 C CD1 . PHE   A 1 150 ? -0.74650  23.28199 -33.16589 1.000 17.24804 ?  150 PHE   A CD1 1 
ATOM   1145 C CD2 . PHE   A 1 150 ? 1.52045   23.48732 -33.88401 1.000 15.49801 ?  150 PHE   A CD2 1 
ATOM   1146 C CE1 . PHE   A 1 150 ? -0.84875  24.65158 -33.07007 1.000 18.80801 ?  150 PHE   A CE1 1 
ATOM   1147 C CE2 . PHE   A 1 150 ? 1.42309   24.86883 -33.78935 1.000 16.48549 ?  150 PHE   A CE2 1 
ATOM   1148 C CZ  . PHE   A 1 150 ? 0.24729   25.45069 -33.38099 1.000 18.87190 ?  150 PHE   A CZ  1 
ATOM   1149 N N   . ASN   A 1 151 ? 3.15207   20.59055 -32.11141 1.000 16.42465 ?  151 ASN   A N   1 
ATOM   1150 C CA  . ASN   A 1 151 ? 4.46899   21.17544 -31.91886 1.000 19.45421 ?  151 ASN   A CA  1 
ATOM   1151 C C   . ASN   A 1 151 ? 5.06518   21.50042 -33.28476 1.000 24.39281 ?  151 ASN   A C   1 
ATOM   1152 O O   . ASN   A 1 151 ? 4.67491   20.94098 -34.30739 1.000 19.95125 ?  151 ASN   A O   1 
ATOM   1153 C CB  . ASN   A 1 151 ? 5.41325   20.21882 -31.17558 1.000 18.88380 ?  151 ASN   A CB  1 
ATOM   1154 C CG  . ASN   A 1 151 ? 5.05388   20.04718 -29.71237 1.000 25.94395 ?  151 ASN   A CG  1 
ATOM   1155 O OD1 . ASN   A 1 151 ? 5.50050   20.81299 -28.85908 1.000 26.83423 ?  151 ASN   A OD1 1 
ATOM   1156 N ND2 . ASN   A 1 151 ? 4.28352   19.00672 -29.40584 1.000 20.55018 ?  151 ASN   A ND2 1 
ATOM   1157 N N   . ILE   A 1 152 ? 6.03320   22.39811 -33.32118 1.000 23.70030 ?  152 ILE   A N   1 
ATOM   1158 C CA  . ILE   A 1 152 ? 6.76223   22.65530 -34.55358 1.000 25.20730 ?  152 ILE   A CA  1 
ATOM   1159 C C   . ILE   A 1 152 ? 8.23441   22.36235 -34.31972 1.000 30.32725 ?  152 ILE   A C   1 
ATOM   1160 O O   . ILE   A 1 152 ? 8.78025   22.70748 -33.26961 1.000 30.23793 ?  152 ILE   A O   1 
ATOM   1161 C CB  . ILE   A 1 152 ? 6.56118   24.09386 -35.03442 1.000 26.60343 ?  152 ILE   A CB  1 
ATOM   1162 C CG1 . ILE   A 1 152 ? 5.07154   24.39531 -35.06644 1.000 26.25168 ?  152 ILE   A CG1 1 
ATOM   1163 C CG2 . ILE   A 1 152 ? 7.21451   24.27560 -36.40705 1.000 30.45628 ?  152 ILE   A CG2 1 
ATOM   1164 C CD1 . ILE   A 1 152 ? 4.69169   25.61132 -35.84582 1.000 26.60297 ?  152 ILE   A CD1 1 
ATOM   1165 N N   . ASP   A 1 153 ? 8.86371   21.71378 -35.28916 1.000 31.29968 ?  153 ASP   A N   1 
ATOM   1166 C CA  . ASP   A 1 153 ? 10.29931  21.46041 -35.30411 1.000 33.38645 ?  153 ASP   A CA  1 
ATOM   1167 C C   . ASP   A 1 153 ? 10.83701  21.96517 -36.64251 1.000 41.03839 ?  153 ASP   A C   1 
ATOM   1168 O O   . ASP   A 1 153 ? 10.64410  21.32198 -37.68195 1.000 38.59344 ?  153 ASP   A O   1 
ATOM   1169 C CB  . ASP   A 1 153 ? 10.60260  19.97799 -35.10285 1.000 39.36968 ?  153 ASP   A CB  1 
ATOM   1170 C CG  . ASP   A 1 153 ? 12.07611  19.66443 -35.25885 1.000 54.21976 ?  153 ASP   A CG  1 
ATOM   1171 O OD1 . ASP   A 1 153 ? 12.62200  19.93867 -36.34630 1.000 56.66483 -1 153 ASP   A OD1 1 
ATOM   1172 O OD2 . ASP   A 1 153 ? 12.68664  19.15505 -34.29354 1.000 57.02976 ?  153 ASP   A OD2 1 
ATOM   1173 N N   . TYR   A 1 154 ? 11.50857  23.11753 -36.60551 1.000 38.05182 ?  154 TYR   A N   1 
ATOM   1174 C CA  . TYR   A 1 154 ? 11.99355  23.84152 -37.77529 1.000 44.37310 ?  154 TYR   A CA  1 
ATOM   1175 C C   . TYR   A 1 154 ? 10.86037  24.13687 -38.74986 1.000 40.12298 ?  154 TYR   A C   1 
ATOM   1176 O O   . TYR   A 1 154 ? 10.17733  25.15595 -38.62052 1.000 37.87193 ?  154 TYR   A O   1 
ATOM   1177 C CB  . TYR   A 1 154 ? 13.12389  23.07518 -38.46418 1.000 43.92846 ?  154 TYR   A CB  1 
ATOM   1178 C CG  . TYR   A 1 154 ? 13.89993  23.93500 -39.44260 1.000 54.13815 ?  154 TYR   A CG  1 
ATOM   1179 C CD1 . TYR   A 1 154 ? 14.63783  25.02501 -39.00003 1.000 60.05895 ?  154 TYR   A CD1 1 
ATOM   1180 C CD2 . TYR   A 1 154 ? 13.88970  23.66114 -40.81669 1.000 58.76014 ?  154 TYR   A CD2 1 
ATOM   1181 C CE1 . TYR   A 1 154 ? 15.34595  25.82135 -39.89440 1.000 70.62527 ?  154 TYR   A CE1 1 
ATOM   1182 C CE2 . TYR   A 1 154 ? 14.59706  24.45210 -41.71919 1.000 60.86834 ?  154 TYR   A CE2 1 
ATOM   1183 C CZ  . TYR   A 1 154 ? 15.32172  25.53039 -41.24891 1.000 70.42217 ?  154 TYR   A CZ  1 
ATOM   1184 O OH  . TYR   A 1 154 ? 16.02629  26.31853 -42.12990 1.000 80.21091 ?  154 TYR   A OH  1 
ATOM   1185 N N   . ASP   A 1 155 ? 10.64775  23.26168 -39.72988 1.000 40.58995 ?  155 ASP   A N   1 
ATOM   1186 C CA  . ASP   A 1 155 ? 9.58391   23.45912 -40.70998 1.000 41.76648 ?  155 ASP   A CA  1 
ATOM   1187 C C   . ASP   A 1 155 ? 8.46115   22.43226 -40.58381 1.000 38.08816 ?  155 ASP   A C   1 
ATOM   1188 O O   . ASP   A 1 155 ? 7.42694   22.57187 -41.25521 1.000 33.34032 ?  155 ASP   A O   1 
ATOM   1189 C CB  . ASP   A 1 155 ? 10.15194  23.43543 -42.14341 1.000 39.93384 ?  155 ASP   A CB  1 
ATOM   1190 C CG  . ASP   A 1 155 ? 10.94224  22.14213 -42.46003 1.000 44.26409 ?  155 ASP   A CG  1 
ATOM   1191 O OD1 . ASP   A 1 155 ? 11.29435  21.36453 -41.53360 1.000 39.54916 ?  155 ASP   A OD1 1 
ATOM   1192 O OD2 . ASP   A 1 155 ? 11.22163  21.90916 -43.65763 1.000 51.44881 -1 155 ASP   A OD2 1 
ATOM   1193 N N   . CYS   A 1 156 ? 8.62520   21.42298 -39.73160 1.000 27.52650 ?  156 CYS   A N   1 
ATOM   1194 C CA  . CYS   A 1 156 ? 7.71435   20.28949 -39.65010 1.000 28.90520 ?  156 CYS   A CA  1 
ATOM   1195 C C   . CYS   A 1 156 ? 6.74188   20.44834 -38.48494 1.000 27.41933 ?  156 CYS   A C   1 
ATOM   1196 O O   . CYS   A 1 156 ? 7.16709   20.59035 -37.33253 1.000 27.34513 ?  156 CYS   A O   1 
ATOM   1197 C CB  . CYS   A 1 156 ? 8.51932   19.00146 -39.48826 1.000 26.44136 ?  156 CYS   A CB  1 
ATOM   1198 S SG  . CYS   A 1 156 ? 7.54239   17.51339 -39.40470 1.000 29.70973 ?  156 CYS   A SG  1 
ATOM   1199 N N   . VAL   A 1 157 ? 5.44634   20.37935 -38.78029 1.000 24.92293 ?  157 VAL   A N   1 
ATOM   1200 C CA  . VAL   A 1 157 ? 4.39742   20.45355 -37.77156 1.000 21.67825 ?  157 VAL   A CA  1 
ATOM   1201 C C   . VAL   A 1 157 ? 4.06739   19.03917 -37.32504 1.000 23.52935 ?  157 VAL   A C   1 
ATOM   1202 O O   . VAL   A 1 157 ? 3.59965   18.22716 -38.13159 1.000 18.62689 ?  157 VAL   A O   1 
ATOM   1203 C CB  . VAL   A 1 157 ? 3.12819   21.13788 -38.30978 1.000 21.01409 ?  157 VAL   A CB  1 
ATOM   1204 C CG1 . VAL   A 1 157 ? 2.06158   21.19161 -37.19033 1.000 15.08448 ?  157 VAL   A CG1 1 
ATOM   1205 C CG2 . VAL   A 1 157 ? 3.42674   22.50974 -38.85274 1.000 16.09152 ?  157 VAL   A CG2 1 
ATOM   1206 N N   . SER   A 1 158 ? 4.26129   18.74890 -36.03393 1.000 17.68917 ?  158 SER   A N   1 
ATOM   1207 C CA  . SER   A 1 158 ? 3.83350   17.48153 -35.45691 1.000 18.10552 ?  158 SER   A CA  1 
ATOM   1208 C C   . SER   A 1 158 ? 2.48391   17.70448 -34.77813 1.000 19.34058 ?  158 SER   A C   1 
ATOM   1209 O O   . SER   A 1 158 ? 2.40983   18.33417 -33.72052 1.000 21.10066 ?  158 SER   A O   1 
ATOM   1210 C CB  . SER   A 1 158 ? 4.87410   16.95421 -34.47680 1.000 18.52618 ?  158 SER   A CB  1 
ATOM   1211 O OG  . SER   A 1 158 ? 6.04953   16.57537 -35.17274 1.000 26.48064 ?  158 SER   A OG  1 
ATOM   1212 N N   . PHE   A 1 159 ? 1.42097   17.21734 -35.40909 1.000 17.04222 ?  159 PHE   A N   1 
ATOM   1213 C CA  . PHE   A 1 159 ? 0.09230   17.22774 -34.81799 1.000 18.68416 ?  159 PHE   A CA  1 
ATOM   1214 C C   . PHE   A 1 159 ? -0.01841  16.10614 -33.80068 1.000 18.05185 ?  159 PHE   A C   1 
ATOM   1215 O O   . PHE   A 1 159 ? 0.32939   14.95889 -34.09206 1.000 17.35208 ?  159 PHE   A O   1 
ATOM   1216 C CB  . PHE   A 1 159 ? -0.96803  17.04677 -35.89463 1.000 17.42171 ?  159 PHE   A CB  1 
ATOM   1217 C CG  . PHE   A 1 159 ? -0.99981  18.13921 -36.89522 1.000 16.24743 ?  159 PHE   A CG  1 
ATOM   1218 C CD1 . PHE   A 1 159 ? -1.63724  19.33787 -36.59499 1.000 12.70356 ?  159 PHE   A CD1 1 
ATOM   1219 C CD2 . PHE   A 1 159 ? -0.40454  17.97785 -38.13779 1.000 11.49221 ?  159 PHE   A CD2 1 
ATOM   1220 C CE1 . PHE   A 1 159 ? -1.69655  20.36940 -37.53632 1.000 18.59847 ?  159 PHE   A CE1 1 
ATOM   1221 C CE2 . PHE   A 1 159 ? -0.46153  18.99721 -39.09227 1.000 12.71365 ?  159 PHE   A CE2 1 
ATOM   1222 C CZ  . PHE   A 1 159 ? -1.09749  20.19526 -38.80331 1.000 13.11134 ?  159 PHE   A CZ  1 
ATOM   1223 N N   . CYS   A 1 160 ? -0.43682  16.43875 -32.58398 1.000 16.91812 ?  160 CYS   A N   1 
ATOM   1224 C CA  . CYS   A 1 160 ? -0.55269  15.40088 -31.58116 1.000 15.32715 ?  160 CYS   A CA  1 
ATOM   1225 C C   . CYS   A 1 160 ? -1.92510  15.28824 -30.95190 1.000 17.05624 ?  160 CYS   A C   1 
ATOM   1226 O O   . CYS   A 1 160 ? -2.17480  14.30206 -30.25619 1.000 18.94931 ?  160 CYS   A O   1 
ATOM   1227 C CB  . CYS   A 1 160 ? 0.49078   15.59321 -30.48092 1.000 15.21173 ?  160 CYS   A CB  1 
ATOM   1228 S SG  . CYS   A 1 160 ? 0.51269   17.20158 -29.68058 1.000 18.42830 ?  160 CYS   A SG  1 
ATOM   1229 N N   . TYR   A 1 161 ? -2.82177  16.24620 -31.16180 1.000 18.08856 ?  161 TYR   A N   1 
ATOM   1230 C CA  . TYR   A 1 161 ? -4.05604  16.26548 -30.38517 1.000 18.71730 ?  161 TYR   A CA  1 
ATOM   1231 C C   . TYR   A 1 161 ? -5.17411  16.80281 -31.25403 1.000 17.25431 ?  161 TYR   A C   1 
ATOM   1232 O O   . TYR   A 1 161 ? -4.95798  17.68439 -32.08955 1.000 13.85495 ?  161 TYR   A O   1 
ATOM   1233 C CB  . TYR   A 1 161 ? -3.92478  17.12200 -29.09902 1.000 18.64744 ?  161 TYR   A CB  1 
ATOM   1234 C CG  . TYR   A 1 161 ? -5.18805  17.25115 -28.23085 1.000 14.03328 ?  161 TYR   A CG  1 
ATOM   1235 C CD1 . TYR   A 1 161 ? -5.44969  16.34659 -27.21863 1.000 15.24252 ?  161 TYR   A CD1 1 
ATOM   1236 C CD2 . TYR   A 1 161 ? -6.07598  18.30078 -28.41925 1.000 15.94187 ?  161 TYR   A CD2 1 
ATOM   1237 C CE1 . TYR   A 1 161 ? -6.57840  16.45729 -26.42015 1.000 17.46725 ?  161 TYR   A CE1 1 
ATOM   1238 C CE2 . TYR   A 1 161 ? -7.22194  18.44065 -27.63628 1.000 13.75297 ?  161 TYR   A CE2 1 
ATOM   1239 C CZ  . TYR   A 1 161 ? -7.46398  17.50437 -26.63465 1.000 16.07395 ?  161 TYR   A CZ  1 
ATOM   1240 O OH  . TYR   A 1 161 ? -8.58119  17.61542 -25.85588 1.000 14.29607 ?  161 TYR   A OH  1 
ATOM   1241 N N   . MET   A 1 162 ? -6.36444  16.25461 -31.04474 1.000 16.79919 ?  162 MET   A N   1 
ATOM   1242 C CA  . MET   A 1 162 ? -7.58486  16.77676 -31.62224 1.000 18.36571 ?  162 MET   A CA  1 
ATOM   1243 C C   . MET   A 1 162 ? -8.64107  16.74189 -30.53476 1.000 13.90864 ?  162 MET   A C   1 
ATOM   1244 O O   . MET   A 1 162 ? -8.84671  15.70366 -29.89465 1.000 14.93518 ?  162 MET   A O   1 
ATOM   1245 C CB  . MET   A 1 162 ? -8.04325  15.97022 -32.83549 1.000 16.25156 ?  162 MET   A CB  1 
ATOM   1246 C CG  . MET   A 1 162 ? -9.42607  16.42144 -33.33813 1.000 16.00068 ?  162 MET   A CG  1 
ATOM   1247 S SD  . MET   A 1 162 ? -9.85417  15.75245 -34.97085 1.000 25.58679 ?  162 MET   A SD  1 
ATOM   1248 C CE  . MET   A 1 162 ? -9.07289  16.98530 -36.04177 1.000 18.21387 ?  162 MET   A CE  1 
ATOM   1249 N N   . HIS   A 1 163 ? -9.33210  17.85885 -30.36818 1.000 13.26531 ?  163 HIS   A N   1 
ATOM   1250 C CA  . HIS   A 1 163 ? -10.20312 18.02973 -29.21645 1.000 18.81551 ?  163 HIS   A CA  1 
ATOM   1251 C C   . HIS   A 1 163 ? -11.56073 17.37041 -29.44592 1.000 14.38380 ?  163 HIS   A C   1 
ATOM   1252 O O   . HIS   A 1 163 ? -12.18199 17.58240 -30.49094 1.000 16.31739 ?  163 HIS   A O   1 
ATOM   1253 C CB  . HIS   A 1 163 ? -10.40001 19.51608 -28.91143 1.000 15.02542 ?  163 HIS   A CB  1 
ATOM   1254 C CG  . HIS   A 1 163 ? -11.30261 19.73364 -27.74303 1.000 16.03462 ?  163 HIS   A CG  1 
ATOM   1255 N ND1 . HIS   A 1 163 ? -10.99442 19.25047 -26.49074 1.000 17.27762 ?  163 HIS   A ND1 1 
ATOM   1256 C CD2 . HIS   A 1 163 ? -12.52958 20.29523 -27.64597 1.000 13.07304 ?  163 HIS   A CD2 1 
ATOM   1257 C CE1 . HIS   A 1 163 ? -11.98417 19.53548 -25.65845 1.000 14.43019 ?  163 HIS   A CE1 1 
ATOM   1258 N NE2 . HIS   A 1 163 ? -12.92510 20.16464 -26.33247 1.000 14.08328 ?  163 HIS   A NE2 1 
ATOM   1259 N N   . HIS   A 1 164 ? -12.05493 16.58816 -28.42598 1.000 14.61971 ?  164 HIS   A N   1 
ATOM   1260 C CA  . HIS   A 1 164 ? -13.36099 15.93772 -28.56106 1.000 15.94318 ?  164 HIS   A CA  1 
ATOM   1261 C C   . HIS   A 1 164 ? -14.36641 16.31403 -27.47521 1.000 21.64965 ?  164 HIS   A C   1 
ATOM   1262 O O   . HIS   A 1 164 ? -15.57509 16.37085 -27.75594 1.000 18.76351 ?  164 HIS   A O   1 
ATOM   1263 C CB  . HIS   A 1 164 ? -13.18704 14.41875 -28.54984 1.000 17.66313 ?  164 HIS   A CB  1 
ATOM   1264 C CG  . HIS   A 1 164 ? -12.60540 13.86089 -29.81234 1.000 19.15440 ?  164 HIS   A CG  1 
ATOM   1265 N ND1 . HIS   A 1 164 ? -13.31794 13.04881 -30.66793 1.000 18.35633 ?  164 HIS   A ND1 1 
ATOM   1266 C CD2 . HIS   A 1 164 ? -11.37771 14.00787 -30.36572 1.000 15.43588 ?  164 HIS   A CD2 1 
ATOM   1267 C CE1 . HIS   A 1 164 ? -12.55150 12.71459 -31.69267 1.000 17.94225 ?  164 HIS   A CE1 1 
ATOM   1268 N NE2 . HIS   A 1 164 ? -11.36676 13.27694 -31.52804 1.000 14.75123 ?  164 HIS   A NE2 1 
ATOM   1269 N N   . MET   A 1 165 ? -13.92002 16.57197 -26.24260 1.000 16.92206 ?  165 MET   A N   1 
ATOM   1270 C CA  . MET   A 1 165 ? -14.91798 16.66801 -25.18805 1.000 24.04088 ?  165 MET   A CA  1 
ATOM   1271 C C   . MET   A 1 165 ? -14.35681 17.32352 -23.92992 1.000 23.46109 ?  165 MET   A C   1 
ATOM   1272 O O   . MET   A 1 165 ? -13.14136 17.45271 -23.73830 1.000 20.60246 ?  165 MET   A O   1 
ATOM   1273 C CB  . MET   A 1 165 ? -15.46076 15.27908 -24.85088 1.000 28.17632 ?  165 MET   A CB  1 
ATOM   1274 C CG  . MET   A 1 165 ? -14.40454 14.43996 -24.15526 1.000 25.63975 ?  165 MET   A CG  1 
ATOM   1275 S SD  . MET   A 1 165 ? -14.98906 12.77072 -23.89464 1.000 37.40146 ?  165 MET   A SD  1 
ATOM   1276 C CE  . MET   A 1 165 ? -16.70354 13.11551 -23.51727 1.000 32.48976 ?  165 MET   A CE  1 
ATOM   1277 N N   . GLU   A 1 166 ? -15.28512 17.69256 -23.05093 1.000 21.34103 ?  166 GLU   A N   1 
ATOM   1278 C CA  . GLU   A 1 166 ? -15.00250 18.23929 -21.74265 1.000 23.13087 ?  166 GLU   A CA  1 
ATOM   1279 C C   . GLU   A 1 166 ? -15.50126 17.27771 -20.67015 1.000 27.42326 ?  166 GLU   A C   1 
ATOM   1280 O O   . GLU   A 1 166 ? -16.53153 16.62031 -20.83452 1.000 25.78226 ?  166 GLU   A O   1 
ATOM   1281 C CB  . GLU   A 1 166 ? -15.66294 19.61226 -21.58908 1.000 25.70357 ?  166 GLU   A CB  1 
ATOM   1282 C CG  . GLU   A 1 166 ? -15.18217 20.36592 -20.35158 1.000 28.92647 ?  166 GLU   A CG  1 
ATOM   1283 C CD  . GLU   A 1 166 ? -15.81079 21.75428 -20.23076 1.000 30.01118 ?  166 GLU   A CD  1 
ATOM   1284 O OE1 . GLU   A 1 166 ? -15.79490 22.52276 -21.22608 1.000 29.79108 ?  166 GLU   A OE1 1 
ATOM   1285 O OE2 . GLU   A 1 166 ? -16.33611 22.05770 -19.13426 1.000 35.44874 -1 166 GLU   A OE2 1 
ATOM   1286 N N   . LEU   A 1 167 ? -14.75675 17.19818 -19.56853 1.000 22.16444 ?  167 LEU   A N   1 
ATOM   1287 C CA  . LEU   A 1 167 ? -15.05742 16.32457 -18.45361 1.000 24.67487 ?  167 LEU   A CA  1 
ATOM   1288 C C   . LEU   A 1 167 ? -15.71796 17.11280 -17.33304 1.000 30.74501 ?  167 LEU   A C   1 
ATOM   1289 O O   . LEU   A 1 167 ? -15.58840 18.33961 -17.27082 1.000 28.02552 ?  167 LEU   A O   1 
ATOM   1290 C CB  . LEU   A 1 167 ? -13.77307 15.65191 -17.94252 1.000 25.47942 ?  167 LEU   A CB  1 
ATOM   1291 C CG  . LEU   A 1 167 ? -13.02969 14.82769 -19.00267 1.000 26.33343 ?  167 LEU   A CG  1 
ATOM   1292 C CD1 . LEU   A 1 167 ? -11.78789 14.14769 -18.42920 1.000 31.11642 ?  167 LEU   A CD1 1 
ATOM   1293 C CD2 . LEU   A 1 167 ? -13.94753 13.81503 -19.68106 1.000 28.17882 ?  167 LEU   A CD2 1 
ATOM   1294 N N   . PRO   A 1 168 ? -16.44480 16.43493 -16.42623 1.000 30.24983 ?  168 PRO   A N   1 
ATOM   1295 C CA  . PRO   A 1 168 ? -17.18095 17.16733 -15.38358 1.000 28.28452 ?  168 PRO   A CA  1 
ATOM   1296 C C   . PRO   A 1 168 ? -16.30635 18.06702 -14.55026 1.000 31.07262 ?  168 PRO   A C   1 
ATOM   1297 O O   . PRO   A 1 168 ? -16.79841 19.08083 -14.04418 1.000 34.54283 ?  168 PRO   A O   1 
ATOM   1298 C CB  . PRO   A 1 168 ? -17.79801 16.04483 -14.53443 1.000 31.38031 ?  168 PRO   A CB  1 
ATOM   1299 C CG  . PRO   A 1 168 ? -17.94472 14.90236 -15.49696 1.000 31.02579 ?  168 PRO   A CG  1 
ATOM   1300 C CD  . PRO   A 1 168 ? -16.72481 14.98760 -16.36711 1.000 27.47877 ?  168 PRO   A CD  1 
ATOM   1301 N N   . THR   A 1 169 ? -15.02038 17.75273 -14.40561 1.000 26.59190 ?  169 THR   A N   1 
ATOM   1302 C CA  . THR   A 1 169 ? -14.15506 18.58597 -13.57894 1.000 26.30887 ?  169 THR   A CA  1 
ATOM   1303 C C   . THR   A 1 169 ? -13.71161 19.86989 -14.27242 1.000 31.27488 ?  169 THR   A C   1 
ATOM   1304 O O   . THR   A 1 169 ? -12.95313 20.64549 -13.67875 1.000 35.06419 ?  169 THR   A O   1 
ATOM   1305 C CB  . THR   A 1 169 ? -12.91283 17.79222 -13.15505 1.000 41.71180 ?  169 THR   A CB  1 
ATOM   1306 O OG1 . THR   A 1 169 ? -12.41955 17.04201 -14.27478 1.000 39.09990 ?  169 THR   A OG1 1 
ATOM   1307 C CG2 . THR   A 1 169 ? -13.23217 16.84358 -11.98815 1.000 35.16481 ?  169 THR   A CG2 1 
ATOM   1308 N N   . GLY   A 1 170 ? -14.12995 20.10263 -15.51608 1.000 31.39063 ?  170 GLY   A N   1 
ATOM   1309 C CA  . GLY   A 1 170 ? -13.69280 21.25255 -16.26910 1.000 27.36486 ?  170 GLY   A CA  1 
ATOM   1310 C C   . GLY   A 1 170 ? -12.52705 21.00329 -17.20689 1.000 27.52101 ?  170 GLY   A C   1 
ATOM   1311 O O   . GLY   A 1 170 ? -12.21556 21.88686 -18.01025 1.000 29.73723 ?  170 GLY   A O   1 
ATOM   1312 N N   . VAL   A 1 171 ? -11.86459 19.84177 -17.13014 1.000 25.81354 ?  171 VAL   A N   1 
ATOM   1313 C CA  . VAL   A 1 171 ? -10.69990 19.57537 -17.97194 1.000 22.40782 ?  171 VAL   A CA  1 
ATOM   1314 C C   . VAL   A 1 171 ? -11.15139 18.99283 -19.30382 1.000 21.41892 ?  171 VAL   A C   1 
ATOM   1315 O O   . VAL   A 1 171 ? -12.34317 18.74327 -19.52263 1.000 23.49502 ?  171 VAL   A O   1 
ATOM   1316 C CB  . VAL   A 1 171 ? -9.67386  18.64218 -17.28908 1.000 21.58739 ?  171 VAL   A CB  1 
ATOM   1317 C CG1 . VAL   A 1 171 ? -9.06527  19.30031 -16.06146 1.000 25.98582 ?  171 VAL   A CG1 1 
ATOM   1318 C CG2 . VAL   A 1 171 ? -10.29681 17.30164 -16.95058 1.000 26.00413 ?  171 VAL   A CG2 1 
ATOM   1319 N N   . HIS   A 1 172 ? -10.19970 18.74786 -20.19928 1.000 20.14288 ?  172 HIS   A N   1 
ATOM   1320 C CA  . HIS   A 1 172 ? -10.54080 18.40566 -21.56949 1.000 20.97408 ?  172 HIS   A CA  1 
ATOM   1321 C C   . HIS   A 1 172 ? -9.84984  17.12986 -22.00902 1.000 18.83151 ?  172 HIS   A C   1 
ATOM   1322 O O   . HIS   A 1 172 ? -8.82526  16.72640 -21.45005 1.000 19.52620 ?  172 HIS   A O   1 
ATOM   1323 C CB  . HIS   A 1 172 ? -10.21297 19.55591 -22.49348 1.000 18.08157 ?  172 HIS   A CB  1 
ATOM   1324 C CG  . HIS   A 1 172 ? -10.94329 20.79632 -22.12199 1.000 19.91619 ?  172 HIS   A CG  1 
ATOM   1325 N ND1 . HIS   A 1 172 ? -10.36551 21.80491 -21.38056 1.000 24.01965 ?  172 HIS   A ND1 1 
ATOM   1326 C CD2 . HIS   A 1 172 ? -12.23305 21.15561 -22.31274 1.000 21.44814 ?  172 HIS   A CD2 1 
ATOM   1327 C CE1 . HIS   A 1 172 ? -11.25871 22.75327 -21.16907 1.000 23.39648 ?  172 HIS   A CE1 1 
ATOM   1328 N NE2 . HIS   A 1 172 ? -12.40189 22.37806 -21.71334 1.000 22.99376 ?  172 HIS   A NE2 1 
ATOM   1329 N N   . ALA   A 1 173 ? -10.47115 16.47308 -22.99038 1.000 19.04070 ?  173 ALA   A N   1 
ATOM   1330 C CA  . ALA   A 1 173 ? -10.00557 15.19656 -23.50962 1.000 18.77697 ?  173 ALA   A CA  1 
ATOM   1331 C C   . ALA   A 1 173 ? -10.18976 15.12644 -25.02278 1.000 19.00219 ?  173 ALA   A C   1 
ATOM   1332 O O   . ALA   A 1 173 ? -11.07525 15.76349 -25.62120 1.000 17.16462 ?  173 ALA   A O   1 
ATOM   1333 C CB  . ALA   A 1 173 ? -10.70345 14.01445 -22.81788 1.000 16.98358 ?  173 ALA   A CB  1 
ATOM   1334 N N   . GLY   A 1 174 ? -9.27735  14.38408 -25.63740 1.000 17.71794 ?  174 GLY   A N   1 
ATOM   1335 C CA  . GLY   A 1 174 ? -9.24107  14.28165 -27.07004 1.000 14.77296 ?  174 GLY   A CA  1 
ATOM   1336 C C   . GLY   A 1 174 ? -8.40418  13.09914 -27.50460 1.000 16.75496 ?  174 GLY   A C   1 
ATOM   1337 O O   . GLY   A 1 174 ? -8.03068  12.24548 -26.70007 1.000 14.70086 ?  174 GLY   A O   1 
ATOM   1338 N N   . THR   A 1 175 ? -8.11520  13.06821 -28.80027 1.000 13.92896 ?  175 THR   A N   1 
ATOM   1339 C CA  . THR   A 1 175 ? -7.45684  11.93368 -29.43077 1.000 14.10424 ?  175 THR   A CA  1 
ATOM   1340 C C   . THR   A 1 175 ? -6.17265  12.38069 -30.13209 1.000 19.76029 ?  175 THR   A C   1 
ATOM   1341 O O   . THR   A 1 175 ? -5.92405  13.57535 -30.33632 1.000 14.66885 ?  175 THR   A O   1 
ATOM   1342 C CB  . THR   A 1 175 ? -8.39844  11.28176 -30.43872 1.000 19.51706 ?  175 THR   A CB  1 
ATOM   1343 O OG1 . THR   A 1 175 ? -8.54524  12.17028 -31.54796 1.000 19.03824 ?  175 THR   A OG1 1 
ATOM   1344 C CG2 . THR   A 1 175 ? -9.77865  11.05077 -29.80638 1.000 17.23866 ?  175 THR   A CG2 1 
ATOM   1345 N N   . ASP   A 1 176 ? -5.34785  11.41067 -30.52717 1.000 14.82133 ?  176 ASP   A N   1 
ATOM   1346 C CA  . ASP   A 1 176 ? -4.30447  11.72797 -31.48474 1.000 18.30976 ?  176 ASP   A CA  1 
ATOM   1347 C C   . ASP   A 1 176 ? -4.94198  11.85436 -32.86915 1.000 19.64050 ?  176 ASP   A C   1 
ATOM   1348 O O   . ASP   A 1 176 ? -6.16384  11.75242 -33.03227 1.000 19.45708 ?  176 ASP   A O   1 
ATOM   1349 C CB  . ASP   A 1 176 ? -3.18957  10.67695 -31.43197 1.000 20.62873 ?  176 ASP   A CB  1 
ATOM   1350 C CG  . ASP   A 1 176 ? -3.68223  9.26436  -31.70977 1.000 20.38558 ?  176 ASP   A CG  1 
ATOM   1351 O OD1 . ASP   A 1 176 ? -4.70267  9.07472  -32.40450 1.000 20.33322 ?  176 ASP   A OD1 1 
ATOM   1352 O OD2 . ASP   A 1 176 ? -3.03444  8.32762  -31.23415 1.000 22.79738 -1 176 ASP   A OD2 1 
ATOM   1353 N N   . LEU   A 1 177 ? -4.13450  12.10333 -33.88429 1.000 15.32658 ?  177 LEU   A N   1 
ATOM   1354 C CA  . LEU   A 1 177 ? -4.73318  12.24579 -35.20170 1.000 17.31199 ?  177 LEU   A CA  1 
ATOM   1355 C C   . LEU   A 1 177 ? -5.05289  10.90266 -35.85331 1.000 23.69398 ?  177 LEU   A C   1 
ATOM   1356 O O   . LEU   A 1 177 ? -5.54354  10.88705 -36.98467 1.000 26.10161 ?  177 LEU   A O   1 
ATOM   1357 C CB  . LEU   A 1 177 ? -3.84133  13.09332 -36.10270 1.000 15.09702 ?  177 LEU   A CB  1 
ATOM   1358 C CG  . LEU   A 1 177 ? -4.09214  14.61656 -36.05910 1.000 16.60576 ?  177 LEU   A CG  1 
ATOM   1359 C CD1 . LEU   A 1 177 ? -5.41372  14.99619 -36.68723 1.000 18.05916 ?  177 LEU   A CD1 1 
ATOM   1360 C CD2 . LEU   A 1 177 ? -4.03551  15.16279 -34.62872 1.000 15.35996 ?  177 LEU   A CD2 1 
ATOM   1361 N N   . GLU   A 1 178 ? -4.80244  9.77996  -35.17429 1.000 22.25109 ?  178 GLU   A N   1 
ATOM   1362 C CA  . GLU   A 1 178 ? -5.37601  8.49951  -35.57230 1.000 21.51032 ?  178 GLU   A CA  1 
ATOM   1363 C C   . GLU   A 1 178 ? -6.67702  8.19817  -34.83421 1.000 23.81639 ?  178 GLU   A C   1 
ATOM   1364 O O   . GLU   A 1 178 ? -7.21917  7.09774  -34.96865 1.000 23.52047 ?  178 GLU   A O   1 
ATOM   1365 C CB  . GLU   A 1 178 ? -4.35667  7.37294  -35.35968 1.000 25.14373 ?  178 GLU   A CB  1 
ATOM   1366 C CG  . GLU   A 1 178 ? -3.14605  7.53768  -36.25852 1.000 30.32895 ?  178 GLU   A CG  1 
ATOM   1367 C CD  . GLU   A 1 178 ? -2.09137  6.48540  -36.03229 1.000 41.99861 ?  178 GLU   A CD  1 
ATOM   1368 O OE1 . GLU   A 1 178 ? -1.92642  6.02907  -34.87670 1.000 37.80639 ?  178 GLU   A OE1 1 
ATOM   1369 O OE2 . GLU   A 1 178 ? -1.42290  6.12186  -37.02427 1.000 46.05080 -1 178 GLU   A OE2 1 
ATOM   1370 N N   . GLY   A 1 179 ? -7.18420  9.14440  -34.05258 1.000 18.97787 ?  179 GLY   A N   1 
ATOM   1371 C CA  . GLY   A 1 179 ? -8.47400  8.98184  -33.42066 1.000 21.36288 ?  179 GLY   A CA  1 
ATOM   1372 C C   . GLY   A 1 179 ? -8.47853  8.13890  -32.17051 1.000 20.19237 ?  179 GLY   A C   1 
ATOM   1373 O O   . GLY   A 1 179 ? -9.55140  7.80886  -31.66643 1.000 17.80238 ?  179 GLY   A O   1 
ATOM   1374 N N   . ASN   A 1 180 ? -7.32465  7.75630  -31.65124 1.000 21.53713 ?  180 ASN   A N   1 
ATOM   1375 C CA  . ASN   A 1 180 ? -7.27899  7.03425  -30.38290 1.000 20.14472 ?  180 ASN   A CA  1 
ATOM   1376 C C   . ASN   A 1 180 ? -7.22627  8.05365  -29.25466 1.000 21.25790 ?  180 ASN   A C   1 
ATOM   1377 O O   . ASN   A 1 180 ? -6.32423  8.90500  -29.22209 1.000 17.82960 ?  180 ASN   A O   1 
ATOM   1378 C CB  . ASN   A 1 180 ? -6.07569  6.09839  -30.34516 1.000 22.87939 ?  180 ASN   A CB  1 
ATOM   1379 C CG  . ASN   A 1 180 ? -6.14757  5.05005  -31.41786 1.000 28.36858 ?  180 ASN   A CG  1 
ATOM   1380 O OD1 . ASN   A 1 180 ? -7.17921  4.39978  -31.59544 1.000 29.10281 ?  180 ASN   A OD1 1 
ATOM   1381 N ND2 . ASN   A 1 180 ? -5.07952  4.91961  -32.18088 1.000 28.01145 ?  180 ASN   A ND2 1 
ATOM   1382 N N   . PHE   A 1 181 ? -8.18867  7.96811  -28.34104 1.000 19.36731 ?  181 PHE   A N   1 
ATOM   1383 C CA  . PHE   A 1 181 ? -8.21549  8.86028  -27.20006 1.000 18.60923 ?  181 PHE   A CA  1 
ATOM   1384 C C   . PHE   A 1 181 ? -6.92215  8.78243  -26.40236 1.000 22.09968 ?  181 PHE   A C   1 
ATOM   1385 O O   . PHE   A 1 181 ? -6.29446  7.72664  -26.29745 1.000 17.60341 ?  181 PHE   A O   1 
ATOM   1386 C CB  . PHE   A 1 181 ? -9.39924  8.52390  -26.28693 1.000 18.29468 ?  181 PHE   A CB  1 
ATOM   1387 C CG  . PHE   A 1 181 ? -10.59525 9.38258  -26.53704 1.000 20.75282 ?  181 PHE   A CG  1 
ATOM   1388 C CD1 . PHE   A 1 181 ? -10.74603 10.59138 -25.86319 1.000 21.77347 ?  181 PHE   A CD1 1 
ATOM   1389 C CD2 . PHE   A 1 181 ? -11.55883 9.00011  -27.45109 1.000 18.04132 ?  181 PHE   A CD2 1 
ATOM   1390 C CE1 . PHE   A 1 181 ? -11.82843 11.40044 -26.08970 1.000 18.22730 ?  181 PHE   A CE1 1 
ATOM   1391 C CE2 . PHE   A 1 181 ? -12.65522 9.80640  -27.69137 1.000 21.61976 ?  181 PHE   A CE2 1 
ATOM   1392 C CZ  . PHE   A 1 181 ? -12.78726 11.00917 -27.01770 1.000 23.08002 ?  181 PHE   A CZ  1 
ATOM   1393 N N   . TYR   A 1 182 ? -6.52415  9.91874  -25.83551 1.000 18.86463 ?  182 TYR   A N   1 
ATOM   1394 C CA  . TYR   A 1 182 ? -5.62812  9.88913  -24.68788 1.000 18.61180 ?  182 TYR   A CA  1 
ATOM   1395 C C   . TYR   A 1 182 ? -6.48213  9.59181  -23.46225 1.000 18.68693 ?  182 TYR   A C   1 
ATOM   1396 O O   . TYR   A 1 182 ? -7.53689  10.19699 -23.28523 1.000 19.38363 ?  182 TYR   A O   1 
ATOM   1397 C CB  . TYR   A 1 182 ? -4.88752  11.21741 -24.52606 1.000 20.35416 ?  182 TYR   A CB  1 
ATOM   1398 C CG  . TYR   A 1 182 ? -3.86802  11.51380 -25.62651 1.000 21.03906 ?  182 TYR   A CG  1 
ATOM   1399 C CD1 . TYR   A 1 182 ? -2.55593  11.04627 -25.53993 1.000 20.17348 ?  182 TYR   A CD1 1 
ATOM   1400 C CD2 . TYR   A 1 182 ? -4.21919  12.27228 -26.72243 1.000 14.91476 ?  182 TYR   A CD2 1 
ATOM   1401 C CE1 . TYR   A 1 182 ? -1.61877  11.33655 -26.53702 1.000 21.22061 ?  182 TYR   A CE1 1 
ATOM   1402 C CE2 . TYR   A 1 182 ? -3.30083  12.58359 -27.72632 1.000 15.99365 ?  182 TYR   A CE2 1 
ATOM   1403 C CZ  . TYR   A 1 182 ? -2.00817  12.10199 -27.62708 1.000 18.94323 ?  182 TYR   A CZ  1 
ATOM   1404 O OH  . TYR   A 1 182 ? -1.12028  12.39838 -28.60947 1.000 17.28959 ?  182 TYR   A OH  1 
ATOM   1405 N N   . GLY   A 1 183 ? -6.05832  8.64575  -22.63896 1.000 19.10575 ?  183 GLY   A N   1 
ATOM   1406 C CA  . GLY   A 1 183 ? -6.80453  8.30650  -21.45178 1.000 23.54021 ?  183 GLY   A CA  1 
ATOM   1407 C C   . GLY   A 1 183 ? -7.93847  7.32947  -21.70628 1.000 27.01389 ?  183 GLY   A C   1 
ATOM   1408 O O   . GLY   A 1 183 ? -8.19427  6.89748  -22.83972 1.000 22.91582 ?  183 GLY   A O   1 
ATOM   1409 N N   . PRO   A 1 184 ? -8.65069  6.96429  -20.62354 1.000 26.24935 ?  184 PRO   A N   1 
ATOM   1410 C CA  . PRO   A 1 184 ? -9.74411  5.98343  -20.70706 1.000 30.12491 ?  184 PRO   A CA  1 
ATOM   1411 C C   . PRO   A 1 184 ? -11.09267 6.64391  -20.97398 1.000 31.12095 ?  184 PRO   A C   1 
ATOM   1412 O O   . PRO   A 1 184 ? -12.07222 6.40374  -20.26996 1.000 37.02496 ?  184 PRO   A O   1 
ATOM   1413 C CB  . PRO   A 1 184 ? -9.70809  5.32992  -19.32297 1.000 30.80204 ?  184 PRO   A CB  1 
ATOM   1414 C CG  . PRO   A 1 184 ? -9.33614  6.50515  -18.41153 1.000 27.43733 ?  184 PRO   A CG  1 
ATOM   1415 C CD  . PRO   A 1 184 ? -8.44240  7.43208  -19.24272 1.000 20.71626 ?  184 PRO   A CD  1 
ATOM   1416 N N   . PHE   A 1 185 ? -11.14249 7.51576  -21.96780 1.000 28.51464 ?  185 PHE   A N   1 
ATOM   1417 C CA  . PHE   A 1 185 ? -12.34100 8.27519  -22.27364 1.000 28.14477 ?  185 PHE   A CA  1 
ATOM   1418 C C   . PHE   A 1 185 ? -12.93443 7.79942  -23.59349 1.000 22.30780 ?  185 PHE   A C   1 
ATOM   1419 O O   . PHE   A 1 185 ? -12.23354 7.26772  -24.45897 1.000 26.91207 ?  185 PHE   A O   1 
ATOM   1420 C CB  . PHE   A 1 185 ? -12.03455 9.78098  -22.32223 1.000 23.63087 ?  185 PHE   A CB  1 
ATOM   1421 C CG  . PHE   A 1 185 ? -11.30334 10.28256 -21.09937 1.000 29.14814 ?  185 PHE   A CG  1 
ATOM   1422 C CD1 . PHE   A 1 185 ? -11.91286 10.26027 -19.85308 1.000 27.28749 ?  185 PHE   A CD1 1 
ATOM   1423 C CD2 . PHE   A 1 185 ? -9.99290  10.75713 -21.19524 1.000 24.47242 ?  185 PHE   A CD2 1 
ATOM   1424 C CE1 . PHE   A 1 185 ? -11.22175 10.70297 -18.71815 1.000 28.44149 ?  185 PHE   A CE1 1 
ATOM   1425 C CE2 . PHE   A 1 185 ? -9.29492  11.20035 -20.07093 1.000 21.03061 ?  185 PHE   A CE2 1 
ATOM   1426 C CZ  . PHE   A 1 185 ? -9.90022  11.18023 -18.83643 1.000 23.49797 ?  185 PHE   A CZ  1 
ATOM   1427 N N   . VAL   A 1 186 ? -14.24403 7.96708  -23.72125 1.000 21.08972 ?  186 VAL   A N   1 
ATOM   1428 C CA  . VAL   A 1 186 ? -14.96925 7.65489  -24.94341 1.000 21.10474 ?  186 VAL   A CA  1 
ATOM   1429 C C   . VAL   A 1 186 ? -15.73114 8.89793  -25.38555 1.000 24.22989 ?  186 VAL   A C   1 
ATOM   1430 O O   . VAL   A 1 186 ? -16.05324 9.78106  -24.58541 1.000 22.65711 ?  186 VAL   A O   1 
ATOM   1431 C CB  . VAL   A 1 186 ? -15.92873 6.46441  -24.75032 1.000 22.04459 ?  186 VAL   A CB  1 
ATOM   1432 C CG1 . VAL   A 1 186 ? -15.13302 5.19741  -24.46244 1.000 23.41878 ?  186 VAL   A CG1 1 
ATOM   1433 C CG2 . VAL   A 1 186 ? -16.89039 6.74771  -23.61124 1.000 25.26230 ?  186 VAL   A CG2 1 
ATOM   1434 N N   . ASP   A 1 187 ? -16.03395 8.95610  -26.68186 1.000 19.34470 ?  187 ASP   A N   1 
ATOM   1435 C CA  . ASP   A 1 187 ? -16.71428 10.12275 -27.22962 1.000 21.32303 ?  187 ASP   A CA  1 
ATOM   1436 C C   . ASP   A 1 187 ? -18.23503 9.91866  -27.17372 1.000 23.42899 ?  187 ASP   A C   1 
ATOM   1437 O O   . ASP   A 1 187 ? -18.91905 9.71369  -28.18199 1.000 22.26924 ?  187 ASP   A O   1 
ATOM   1438 C CB  . ASP   A 1 187 ? -16.21140 10.43426 -28.64112 1.000 21.67752 ?  187 ASP   A CB  1 
ATOM   1439 C CG  . ASP   A 1 187 ? -16.24174 9.23669  -29.58612 1.000 22.11981 ?  187 ASP   A CG  1 
ATOM   1440 O OD1 . ASP   A 1 187 ? -16.22626 8.07890  -29.11177 1.000 22.67278 ?  187 ASP   A OD1 1 
ATOM   1441 O OD2 . ASP   A 1 187 ? -16.26977 9.47032  -30.82699 1.000 24.33435 -1 187 ASP   A OD2 1 
ATOM   1442 N N   . ARG   A 1 188 ? -18.76308 9.99897  -25.95260 1.000 18.78932 ?  188 ARG   A N   1 
ATOM   1443 C CA  . ARG   A 1 188 ? -20.20603 10.04677 -25.75788 1.000 24.56966 ?  188 ARG   A CA  1 
ATOM   1444 C C   . ARG   A 1 188 ? -20.52111 10.99423 -24.61599 1.000 26.11369 ?  188 ARG   A C   1 
ATOM   1445 O O   . ARG   A 1 188 ? -19.67688 11.25912 -23.75411 1.000 24.25693 ?  188 ARG   A O   1 
ATOM   1446 C CB  . ARG   A 1 188 ? -20.81736 8.66632  -25.48357 1.000 25.25260 ?  188 ARG   A CB  1 
ATOM   1447 C CG  . ARG   A 1 188 ? -20.27813 7.96499  -24.26055 1.000 36.44093 ?  188 ARG   A CG  1 
ATOM   1448 C CD  . ARG   A 1 188 ? -20.97194 6.61846  -24.03596 1.000 33.86790 ?  188 ARG   A CD  1 
ATOM   1449 N NE  . ARG   A 1 188 ? -22.40278 6.78401  -23.81352 1.000 38.54976 ?  188 ARG   A NE  1 
ATOM   1450 C CZ  . ARG   A 1 188 ? -23.11534 6.07177  -22.95082 1.000 42.22682 ?  188 ARG   A CZ  1 
ATOM   1451 N NH1 . ARG   A 1 188 ? -22.55579 5.14363  -22.19243 1.000 44.73107 ?  188 ARG   A NH1 1 
ATOM   1452 N NH2 . ARG   A 1 188 ? -24.42035 6.30595  -22.83530 1.000 44.16292 ?  188 ARG   A NH2 1 
ATOM   1453 N N   . GLN   A 1 189 ? -21.74554 11.52129 -24.62710 1.000 25.47487 ?  189 GLN   A N   1 
ATOM   1454 C CA  . GLN   A 1 189 ? -22.16438 12.46975 -23.59988 1.000 28.07018 ?  189 GLN   A CA  1 
ATOM   1455 C C   . GLN   A 1 189 ? -22.61322 11.66929 -22.38059 1.000 27.05967 ?  189 GLN   A C   1 
ATOM   1456 O O   . GLN   A 1 189 ? -23.78422 11.33065 -22.19977 1.000 27.62935 ?  189 GLN   A O   1 
ATOM   1457 C CB  . GLN   A 1 189 ? -23.25268 13.39093 -24.12229 1.000 27.24811 ?  189 GLN   A CB  1 
ATOM   1458 C CG  . GLN   A 1 189 ? -23.79562 14.34496 -23.08173 1.000 21.11978 ?  189 GLN   A CG  1 
ATOM   1459 C CD  . GLN   A 1 189 ? -24.87550 15.25007 -23.64465 1.000 26.75853 ?  189 GLN   A CD  1 
ATOM   1460 O OE1 . GLN   A 1 189 ? -24.77485 15.71985 -24.78752 1.000 25.34668 ?  189 GLN   A OE1 1 
ATOM   1461 N NE2 . GLN   A 1 189 ? -25.91255 15.50948 -22.84913 1.000 23.87053 ?  189 GLN   A NE2 1 
ATOM   1462 N N   . THR   A 1 190 ? -21.63710 11.32435 -21.54870 1.000 23.09735 ?  190 THR   A N   1 
ATOM   1463 C CA  . THR   A 1 190 ? -21.90800 10.62040 -20.30985 1.000 24.31703 ?  190 THR   A CA  1 
ATOM   1464 C C   . THR   A 1 190 ? -20.85410 11.06053 -19.31386 1.000 27.59297 ?  190 THR   A C   1 
ATOM   1465 O O   . THR   A 1 190 ? -19.78540 11.53802 -19.69493 1.000 29.80695 ?  190 THR   A O   1 
ATOM   1466 C CB  . THR   A 1 190 ? -21.91733 9.09321  -20.50176 1.000 32.64993 ?  190 THR   A CB  1 
ATOM   1467 O OG1 . THR   A 1 190 ? -22.45894 8.46976  -19.33461 1.000 30.25550 ?  190 THR   A OG1 1 
ATOM   1468 C CG2 . THR   A 1 190 ? -20.51719 8.54718  -20.77270 1.000 23.25187 ?  190 THR   A CG2 1 
ATOM   1469 N N   . ALA   A 1 191 ? -21.18614 10.96197 -18.03363 1.000 25.85643 ?  191 ALA   A N   1 
ATOM   1470 C CA  . ALA   A 1 191 ? -20.24792 11.38652 -17.00877 1.000 29.14924 ?  191 ALA   A CA  1 
ATOM   1471 C C   . ALA   A 1 191 ? -19.05071 10.45294 -17.03509 1.000 26.91867 ?  191 ALA   A C   1 
ATOM   1472 O O   . ALA   A 1 191 ? -19.21391 9.22846  -17.02667 1.000 24.13595 ?  191 ALA   A O   1 
ATOM   1473 C CB  . ALA   A 1 191 ? -20.91014 11.38620 -15.63513 1.000 28.75078 ?  191 ALA   A CB  1 
ATOM   1474 N N   . GLN   A 1 192 ? -17.85357 11.02988 -17.09611 1.000 21.50715 ?  192 GLN   A N   1 
ATOM   1475 C CA  . GLN   A 1 192 ? -16.62311 10.26037 -17.10951 1.000 25.81915 ?  192 GLN   A CA  1 
ATOM   1476 C C   . GLN   A 1 192 ? -15.63254 10.91446 -16.16052 1.000 33.25938 ?  192 GLN   A C   1 
ATOM   1477 O O   . GLN   A 1 192 ? -15.51970 12.13940 -16.11746 1.000 35.52003 ?  192 GLN   A O   1 
ATOM   1478 C CB  . GLN   A 1 192 ? -16.03712 10.18122 -18.50992 1.000 27.47590 ?  192 GLN   A CB  1 
ATOM   1479 C CG  . GLN   A 1 192 ? -16.79015 9.25700  -19.45798 1.000 26.08393 ?  192 GLN   A CG  1 
ATOM   1480 C CD  . GLN   A 1 192 ? -16.31635 9.40220  -20.88551 1.000 27.85490 ?  192 GLN   A CD  1 
ATOM   1481 O OE1 . GLN   A 1 192 ? -15.24501 8.92039  -21.24163 1.000 27.22985 ?  192 GLN   A OE1 1 
ATOM   1482 N NE2 . GLN   A 1 192 ? -17.10249 10.09030 -21.70852 1.000 25.64142 ?  192 GLN   A NE2 1 
ATOM   1483 N N   . ALA   A 1 193 ? -14.92168 10.10196 -15.39618 1.000 29.29221 ?  193 ALA   A N   1 
ATOM   1484 C CA  . ALA   A 1 193 ? -13.98801 10.60605 -14.39857 1.000 39.18649 ?  193 ALA   A CA  1 
ATOM   1485 C C   . ALA   A 1 193 ? -12.56172 10.46798 -14.90373 1.000 29.78290 ?  193 ALA   A C   1 
ATOM   1486 O O   . ALA   A 1 193 ? -12.18395 9.42412  -15.45120 1.000 27.57054 ?  193 ALA   A O   1 
ATOM   1487 C CB  . ALA   A 1 193 ? -14.13571 9.86068  -13.06644 1.000 34.65526 ?  193 ALA   A CB  1 
ATOM   1488 N N   . ALA   A 1 194 ? -11.78022 11.52295 -14.71928 1.000 32.20431 ?  194 ALA   A N   1 
ATOM   1489 C CA  . ALA   A 1 194 ? -10.35134 11.44779 -14.94713 1.000 33.12608 ?  194 ALA   A CA  1 
ATOM   1490 C C   . ALA   A 1 194 ? -9.68221  10.76035 -13.76707 1.000 37.76270 ?  194 ALA   A C   1 
ATOM   1491 O O   . ALA   A 1 194 ? -10.11794 10.90120 -12.62022 1.000 35.88961 ?  194 ALA   A O   1 
ATOM   1492 C CB  . ALA   A 1 194 ? -9.76698  12.84930 -15.12984 1.000 32.87868 ?  194 ALA   A CB  1 
ATOM   1493 N N   . GLY   A 1 195 ? -8.61983  10.00670 -14.05602 1.000 33.93276 ?  195 GLY   A N   1 
ATOM   1494 C CA  . GLY   A 1 195 ? -7.77908  9.49560  -12.99493 1.000 31.91390 ?  195 GLY   A CA  1 
ATOM   1495 C C   . GLY   A 1 195 ? -7.23031  10.61827 -12.13470 1.000 36.34279 ?  195 GLY   A C   1 
ATOM   1496 O O   . GLY   A 1 195 ? -7.23795  11.79055 -12.50589 1.000 32.88603 ?  195 GLY   A O   1 
ATOM   1497 N N   . THR   A 1 196 ? -6.78353  10.26659 -10.93789 1.000 38.79513 ?  196 THR   A N   1 
ATOM   1498 C CA  . THR   A 1 196 ? -6.18244  11.28561 -10.09428 1.000 41.45103 ?  196 THR   A CA  1 
ATOM   1499 C C   . THR   A 1 196 ? -4.86339  11.72614 -10.72382 1.000 34.76316 ?  196 THR   A C   1 
ATOM   1500 O O   . THR   A 1 196 ? -4.09245  10.90031 -11.22778 1.000 35.81933 ?  196 THR   A O   1 
ATOM   1501 C CB  . THR   A 1 196 ? -5.98326  10.77086 -8.66711  1.000 42.22807 ?  196 THR   A CB  1 
ATOM   1502 O OG1 . THR   A 1 196 ? -5.35889  11.79754 -7.87822  1.000 40.76783 ?  196 THR   A OG1 1 
ATOM   1503 C CG2 . THR   A 1 196 ? -5.14262  9.49581  -8.66193  1.000 38.16976 ?  196 THR   A CG2 1 
ATOM   1504 N N   . ASP   A 1 197 ? -4.64442  13.03905 -10.75677 1.000 38.59395 ?  197 ASP   A N   1 
ATOM   1505 C CA  . ASP   A 1 197 ? -3.50052  13.60977 -11.44915 1.000 34.76674 ?  197 ASP   A CA  1 
ATOM   1506 C C   . ASP   A 1 197 ? -2.25620  13.60654 -10.55275 1.000 37.93121 ?  197 ASP   A C   1 
ATOM   1507 O O   . ASP   A 1 197 ? -2.32637  13.35204 -9.34952  1.000 38.08782 ?  197 ASP   A O   1 
ATOM   1508 C CB  . ASP   A 1 197 ? -3.83303  15.01938 -11.91443 1.000 31.18290 ?  197 ASP   A CB  1 
ATOM   1509 C CG  . ASP   A 1 197 ? -2.96483  15.46539 -13.06414 1.000 32.11710 ?  197 ASP   A CG  1 
ATOM   1510 O OD1 . ASP   A 1 197 ? -2.40173  14.58743 -13.74322 1.000 26.41004 ?  197 ASP   A OD1 1 
ATOM   1511 O OD2 . ASP   A 1 197 ? -2.84183  16.69768 -13.28323 1.000 37.49435 -1 197 ASP   A OD2 1 
ATOM   1512 N N   . THR   A 1 198 ? -1.10344  13.88779 -11.16812 1.000 33.20000 ?  198 THR   A N   1 
ATOM   1513 C CA  . THR   A 1 198 ? 0.20005   13.90304 -10.51648 1.000 29.89950 ?  198 THR   A CA  1 
ATOM   1514 C C   . THR   A 1 198 ? 0.99379   15.09438 -11.03635 1.000 29.41289 ?  198 THR   A C   1 
ATOM   1515 O O   . THR   A 1 198 ? 0.76633   15.55707 -12.15528 1.000 31.96903 ?  198 THR   A O   1 
ATOM   1516 C CB  . THR   A 1 198 ? 0.99423   12.61819 -10.79810 1.000 31.61296 ?  198 THR   A CB  1 
ATOM   1517 O OG1 . THR   A 1 198 ? 0.10256   11.50310 -10.82557 1.000 46.60976 ?  198 THR   A OG1 1 
ATOM   1518 C CG2 . THR   A 1 198 ? 2.03796   12.38843 -9.71946  1.000 32.37025 ?  198 THR   A CG2 1 
ATOM   1519 N N   . THR   A 1 199 ? 1.92782   15.58689 -10.22141 1.000 24.43506 ?  199 THR   A N   1 
ATOM   1520 C CA  . THR   A 1 199 ? 2.77742   16.70143 -10.62494 1.000 23.99799 ?  199 THR   A CA  1 
ATOM   1521 C C   . THR   A 1 199 ? 3.97816   16.20285 -11.41686 1.000 22.90077 ?  199 THR   A C   1 
ATOM   1522 O O   . THR   A 1 199 ? 4.67850   15.27808 -10.98853 1.000 21.32822 ?  199 THR   A O   1 
ATOM   1523 C CB  . THR   A 1 199 ? 3.24051   17.47925 -9.40039  1.000 27.32629 ?  199 THR   A CB  1 
ATOM   1524 O OG1 . THR   A 1 199 ? 2.09488   18.07701 -8.80082  1.000 21.76610 ?  199 THR   A OG1 1 
ATOM   1525 C CG2 . THR   A 1 199 ? 4.25123   18.59965 -9.78707  1.000 21.22823 ?  199 THR   A CG2 1 
ATOM   1526 N N   . ILE   A 1 200 ? 4.21646   16.82184 -12.57164 1.000 22.92755 ?  200 ILE   A N   1 
ATOM   1527 C CA  . ILE   A 1 200 ? 5.27865   16.39869 -13.48610 1.000 19.14624 ?  200 ILE   A CA  1 
ATOM   1528 C C   . ILE   A 1 200 ? 6.59866   16.93353 -12.93466 1.000 21.13443 ?  200 ILE   A C   1 
ATOM   1529 O O   . ILE   A 1 200 ? 6.96377   18.08282 -13.19968 1.000 20.80001 ?  200 ILE   A O   1 
ATOM   1530 C CB  . ILE   A 1 200 ? 5.02548   16.89298 -14.90635 1.000 20.28711 ?  200 ILE   A CB  1 
ATOM   1531 C CG1 . ILE   A 1 200 ? 3.58008   16.58104 -15.29554 1.000 21.90909 ?  200 ILE   A CG1 1 
ATOM   1532 C CG2 . ILE   A 1 200 ? 6.02297   16.24926 -15.88393 1.000 17.58179 ?  200 ILE   A CG2 1 
ATOM   1533 C CD1 . ILE   A 1 200 ? 3.03396   17.41690 -16.45046 1.000 15.53193 ?  200 ILE   A CD1 1 
ATOM   1534 N N   . THR   A 1 201 ? 7.34040   16.07853 -12.21195 1.000 20.82704 ?  201 THR   A N   1 
ATOM   1535 C CA  . THR   A 1 201 ? 8.54106   16.50742 -11.48950 1.000 20.96446 ?  201 THR   A CA  1 
ATOM   1536 C C   . THR   A 1 201 ? 9.58798   17.12251 -12.41654 1.000 16.53511 ?  201 THR   A C   1 
ATOM   1537 O O   . THR   A 1 201 ? 10.15134  18.18879 -12.12142 1.000 17.50992 ?  201 THR   A O   1 
ATOM   1538 C CB  . THR   A 1 201 ? 9.17059   15.31641 -10.75286 1.000 16.90886 ?  201 THR   A CB  1 
ATOM   1539 O OG1 . THR   A 1 201 ? 8.16354   14.59461 -10.04411 1.000 24.15643 ?  201 THR   A OG1 1 
ATOM   1540 C CG2 . THR   A 1 201 ? 10.24665  15.80210 -9.77878  1.000 17.53335 ?  201 THR   A CG2 1 
ATOM   1541 N N   . VAL   A 1 202 ? 9.90452   16.43785 -13.51377 1.000 16.80945 ?  202 VAL   A N   1 
ATOM   1542 C CA  . VAL   A 1 202 ? 10.94589  16.93319 -14.41573 1.000 15.89113 ?  202 VAL   A CA  1 
ATOM   1543 C C   . VAL   A 1 202 ? 10.57549  18.31123 -14.96812 1.000 16.50976 ?  202 VAL   A C   1 
ATOM   1544 O O   . VAL   A 1 202 ? 11.45670  19.14967 -15.22807 1.000 18.50164 ?  202 VAL   A O   1 
ATOM   1545 C CB  . VAL   A 1 202 ? 11.20178  15.90695 -15.53607 1.000 18.22327 ?  202 VAL   A CB  1 
ATOM   1546 C CG1 . VAL   A 1 202 ? 9.95297   15.73798 -16.40316 1.000 20.71011 ?  202 VAL   A CG1 1 
ATOM   1547 C CG2 . VAL   A 1 202 ? 12.39179  16.31688 -16.37236 1.000 20.20772 ?  202 VAL   A CG2 1 
ATOM   1548 N N   . ASN   A 1 203 ? 9.27533   18.59949 -15.10455 1.000 14.91855 ?  203 ASN   A N   1 
ATOM   1549 C CA  . ASN   A 1 203 ? 8.87871   19.92132 -15.59038 1.000 13.26671 ?  203 ASN   A CA  1 
ATOM   1550 C C   . ASN   A 1 203 ? 9.05763   20.98836 -14.51852 1.000 18.34843 ?  203 ASN   A C   1 
ATOM   1551 O O   . ASN   A 1 203 ? 9.42362   22.13584 -14.83033 1.000 20.04321 ?  203 ASN   A O   1 
ATOM   1552 C CB  . ASN   A 1 203 ? 7.43587   19.92149 -16.07421 1.000 14.67124 ?  203 ASN   A CB  1 
ATOM   1553 C CG  . ASN   A 1 203 ? 7.27830   19.23653 -17.40699 1.000 18.98075 ?  203 ASN   A CG  1 
ATOM   1554 O OD1 . ASN   A 1 203 ? 8.23885   18.69561 -17.94579 1.000 17.28922 ?  203 ASN   A OD1 1 
ATOM   1555 N ND2 . ASN   A 1 203 ? 6.06289   19.25237 -17.94981 1.000 16.89437 ?  203 ASN   A ND2 1 
ATOM   1556 N N   . VAL   A 1 204 ? 8.80883   20.63697 -13.26104 1.000 17.71942 ?  204 VAL   A N   1 
ATOM   1557 C CA  . VAL   A 1 204 ? 9.07275   21.57486 -12.17290 1.000 19.09522 ?  204 VAL   A CA  1 
ATOM   1558 C C   . VAL   A 1 204 ? 10.56188  21.92287 -12.12771 1.000 16.43208 ?  204 VAL   A C   1 
ATOM   1559 O O   . VAL   A 1 204 ? 10.94772  23.08748 -11.94242 1.000 16.49381 ?  204 VAL   A O   1 
ATOM   1560 C CB  . VAL   A 1 204 ? 8.58240   20.97817 -10.83848 1.000 18.47554 ?  204 VAL   A CB  1 
ATOM   1561 C CG1 . VAL   A 1 204 ? 8.92975   21.90783 -9.67369  1.000 20.53954 ?  204 VAL   A CG1 1 
ATOM   1562 C CG2 . VAL   A 1 204 ? 7.09074   20.69823 -10.89410 1.000 17.86366 ?  204 VAL   A CG2 1 
ATOM   1563 N N   . LEU   A 1 205 ? 11.42322  20.92140 -12.28232 1.000 14.06335 ?  205 LEU   A N   1 
ATOM   1564 C CA  . LEU   A 1 205 ? 12.85612  21.21203 -12.25931 1.000 17.93328 ?  205 LEU   A CA  1 
ATOM   1565 C C   . LEU   A 1 205 ? 13.26639  22.08914 -13.43482 1.000 16.56851 ?  205 LEU   A C   1 
ATOM   1566 O O   . LEU   A 1 205 ? 14.08308  23.00386 -13.26764 1.000 17.02998 ?  205 LEU   A O   1 
ATOM   1567 C CB  . LEU   A 1 205 ? 13.66956  19.91103 -12.24165 1.000 13.89199 ?  205 LEU   A CB  1 
ATOM   1568 C CG  . LEU   A 1 205 ? 13.49635  19.10055 -10.93304 1.000 18.68250 ?  205 LEU   A CG  1 
ATOM   1569 C CD1 . LEU   A 1 205 ? 13.91369  17.63996 -11.14647 1.000 13.92228 ?  205 LEU   A CD1 1 
ATOM   1570 C CD2 . LEU   A 1 205 ? 14.25633  19.73759 -9.77879  1.000 12.47130 ?  205 LEU   A CD2 1 
ATOM   1571 N N   . ALA   A 1 206 ? 12.71112  21.82445 -14.62928 1.000 15.30275 ?  206 ALA   A N   1 
ATOM   1572 C CA  . ALA   A 1 206 ? 12.95945  22.69719 -15.77762 1.000 16.99500 ?  206 ALA   A CA  1 
ATOM   1573 C C   . ALA   A 1 206 ? 12.54953  24.13103 -15.47439 1.000 17.86016 ?  206 ALA   A C   1 
ATOM   1574 O O   . ALA   A 1 206 ? 13.27047  25.08369 -15.80087 1.000 16.01170 ?  206 ALA   A O   1 
ATOM   1575 C CB  . ALA   A 1 206 ? 12.18686  22.20312 -17.00461 1.000 13.48176 ?  206 ALA   A CB  1 
ATOM   1576 N N   . TRP   A 1 207 ? 11.38315  24.30122 -14.85685 1.000 14.39674 ?  207 TRP   A N   1 
ATOM   1577 C CA  . TRP   A 1 207 ? 10.90457  25.63872 -14.53145 1.000 15.54972 ?  207 TRP   A CA  1 
ATOM   1578 C C   . TRP   A 1 207 ? 11.80361  26.30923 -13.49708 1.000 16.98006 ?  207 TRP   A C   1 
ATOM   1579 O O   . TRP   A 1 207 ? 12.01953  27.52466 -13.54367 1.000 17.37561 ?  207 TRP   A O   1 
ATOM   1580 C CB  . TRP   A 1 207 ? 9.47045   25.53806 -14.04121 1.000 16.74437 ?  207 TRP   A CB  1 
ATOM   1581 C CG  . TRP   A 1 207 ? 8.82557   26.77972 -13.61243 1.000 17.01036 ?  207 TRP   A CG  1 
ATOM   1582 C CD1 . TRP   A 1 207 ? 8.36739   27.79097 -14.41392 1.000 21.90067 ?  207 TRP   A CD1 1 
ATOM   1583 C CD2 . TRP   A 1 207 ? 8.47825   27.13075 -12.27875 1.000 21.08706 ?  207 TRP   A CD2 1 
ATOM   1584 N NE1 . TRP   A 1 207 ? 7.76249   28.76912 -13.64219 1.000 21.76311 ?  207 TRP   A NE1 1 
ATOM   1585 C CE2 . TRP   A 1 207 ? 7.82456   28.38261 -12.32881 1.000 24.14756 ?  207 TRP   A CE2 1 
ATOM   1586 C CE3 . TRP   A 1 207 ? 8.66335   26.51572 -11.03523 1.000 22.29165 ?  207 TRP   A CE3 1 
ATOM   1587 C CZ2 . TRP   A 1 207 ? 7.35943   29.01984 -11.19104 1.000 21.64010 ?  207 TRP   A CZ2 1 
ATOM   1588 C CZ3 . TRP   A 1 207 ? 8.19422   27.16001 -9.89871  1.000 23.36293 ?  207 TRP   A CZ3 1 
ATOM   1589 C CH2 . TRP   A 1 207 ? 7.55674   28.39453 -9.98833  1.000 25.47561 ?  207 TRP   A CH2 1 
ATOM   1590 N N   . LEU   A 1 208 ? 12.35961  25.53980 -12.56515 1.000 16.54055 ?  208 LEU   A N   1 
ATOM   1591 C CA  . LEU   A 1 208 ? 13.27120  26.14683 -11.58911 1.000 17.27355 ?  208 LEU   A CA  1 
ATOM   1592 C C   . LEU   A 1 208 ? 14.57648  26.60582 -12.26246 1.000 17.27992 ?  208 LEU   A C   1 
ATOM   1593 O O   . LEU   A 1 208 ? 15.13604  27.66327 -11.92276 1.000 15.69923 ?  208 LEU   A O   1 
ATOM   1594 C CB  . LEU   A 1 208 ? 13.54586  25.16139 -10.45630 1.000 12.37341 ?  208 LEU   A CB  1 
ATOM   1595 C CG  . LEU   A 1 208 ? 12.39878  24.89867 -9.47138  1.000 15.67660 ?  208 LEU   A CG  1 
ATOM   1596 C CD1 . LEU   A 1 208 ? 12.82489  23.81855 -8.47095  1.000 14.60511 ?  208 LEU   A CD1 1 
ATOM   1597 C CD2 . LEU   A 1 208 ? 11.93895  26.18450 -8.73497  1.000 11.55252 ?  208 LEU   A CD2 1 
ATOM   1598 N N   . TYR   A 1 209 ? 15.06531  25.83032 -13.23432 1.000 16.14582 ?  209 TYR   A N   1 
ATOM   1599 C CA  . TYR   A 1 209 ? 16.18748  26.29760 -14.05893 1.000 16.41007 ?  209 TYR   A CA  1 
ATOM   1600 C C   . TYR   A 1 209 ? 15.82851  27.58803 -14.78750 1.000 17.80919 ?  209 TYR   A C   1 
ATOM   1601 O O   . TYR   A 1 209 ? 16.60195  28.55726 -14.78415 1.000 19.77348 ?  209 TYR   A O   1 
ATOM   1602 C CB  . TYR   A 1 209 ? 16.60828  25.22086 -15.06901 1.000 15.32556 ?  209 TYR   A CB  1 
ATOM   1603 C CG  . TYR   A 1 209 ? 17.50862  24.15009 -14.47190 1.000 18.05526 ?  209 TYR   A CG  1 
ATOM   1604 C CD1 . TYR   A 1 209 ? 18.83257  24.44570 -14.12545 1.000 19.95549 ?  209 TYR   A CD1 1 
ATOM   1605 C CD2 . TYR   A 1 209 ? 17.06205  22.85339 -14.28109 1.000 16.43407 ?  209 TYR   A CD2 1 
ATOM   1606 C CE1 . TYR   A 1 209 ? 19.66955  23.48909 -13.58372 1.000 20.23929 ?  209 TYR   A CE1 1 
ATOM   1607 C CE2 . TYR   A 1 209 ? 17.91223  21.87819 -13.72075 1.000 19.31740 ?  209 TYR   A CE2 1 
ATOM   1608 C CZ  . TYR   A 1 209 ? 19.20724  22.21064 -13.37869 1.000 21.38935 ?  209 TYR   A CZ  1 
ATOM   1609 O OH  . TYR   A 1 209 ? 20.06933  21.26867 -12.84085 1.000 22.95786 ?  209 TYR   A OH  1 
ATOM   1610 N N   . ALA   A 1 210 ? 14.65591  27.61198 -15.42838 1.000 16.72081 ?  210 ALA   A N   1 
ATOM   1611 C CA  . ALA   A 1 210 ? 14.18393  28.83844 -16.06784 1.000 20.26556 ?  210 ALA   A CA  1 
ATOM   1612 C C   . ALA   A 1 210 ? 14.20729  30.01151 -15.09758 1.000 23.18148 ?  210 ALA   A C   1 
ATOM   1613 O O   . ALA   A 1 210 ? 14.64590  31.11200 -15.45649 1.000 22.49319 ?  210 ALA   A O   1 
ATOM   1614 C CB  . ALA   A 1 210 ? 12.76709  28.65279 -16.61315 1.000 16.58846 ?  210 ALA   A CB  1 
ATOM   1615 N N   . ALA   A 1 211 ? 13.76028  29.78326 -13.86247 1.000 17.23227 ?  211 ALA   A N   1 
ATOM   1616 C CA  . ALA   A 1 211 ? 13.77101  30.83324 -12.85314 1.000 19.96859 ?  211 ALA   A CA  1 
ATOM   1617 C C   . ALA   A 1 211 ? 15.18695  31.31876 -12.56110 1.000 22.27303 ?  211 ALA   A C   1 
ATOM   1618 O O   . ALA   A 1 211 ? 15.41843  32.52241 -12.45086 1.000 24.21904 ?  211 ALA   A O   1 
ATOM   1619 C CB  . ALA   A 1 211 ? 13.11961  30.33712 -11.56517 1.000 17.95006 ?  211 ALA   A CB  1 
ATOM   1620 N N   . VAL   A 1 212 ? 16.14203  30.40107 -12.39120 1.000 23.76550 ?  212 VAL   A N   1 
ATOM   1621 C CA  . VAL   A 1 212 ? 17.51024  30.84214 -12.11227 1.000 22.55122 ?  212 VAL   A CA  1 
ATOM   1622 C C   . VAL   A 1 212 ? 18.03680  31.68759 -13.26802 1.000 28.01592 ?  212 VAL   A C   1 
ATOM   1623 O O   . VAL   A 1 212 ? 18.59693  32.77369 -13.06224 1.000 32.50255 ?  212 VAL   A O   1 
ATOM   1624 C CB  . VAL   A 1 212 ? 18.42781  29.64100 -11.83053 1.000 21.97376 ?  212 VAL   A CB  1 
ATOM   1625 C CG1 . VAL   A 1 212 ? 19.87255  30.09161 -11.78482 1.000 25.14707 ?  212 VAL   A CG1 1 
ATOM   1626 C CG2 . VAL   A 1 212 ? 18.03799  28.96785 -10.52207 1.000 18.27414 ?  212 VAL   A CG2 1 
ATOM   1627 N N   . ILE   A 1 213 ? 17.82672  31.22607 -14.50342 1.000 25.62697 ?  213 ILE   A N   1 
ATOM   1628 C CA  . ILE   A 1 213 ? 18.29214  31.96484 -15.67637 1.000 22.03619 ?  213 ILE   A CA  1 
ATOM   1629 C C   . ILE   A 1 213 ? 17.73656  33.38805 -15.69611 1.000 28.46479 ?  213 ILE   A C   1 
ATOM   1630 O O   . ILE   A 1 213 ? 18.40821  34.31494 -16.16277 1.000 29.94601 ?  213 ILE   A O   1 
ATOM   1631 C CB  . ILE   A 1 213 ? 17.91811  31.18341 -16.95237 1.000 20.97396 ?  213 ILE   A CB  1 
ATOM   1632 C CG1 . ILE   A 1 213 ? 18.71545  29.89437 -17.00365 1.000 18.79718 ?  213 ILE   A CG1 1 
ATOM   1633 C CG2 . ILE   A 1 213 ? 18.17173  32.00354 -18.20536 1.000 29.52612 ?  213 ILE   A CG2 1 
ATOM   1634 C CD1 . ILE   A 1 213 ? 18.26200  28.90979 -18.06439 1.000 21.92976 ?  213 ILE   A CD1 1 
ATOM   1635 N N   . ASN   A 1 214 ? 16.53191  33.59551 -15.15412 1.000 25.82379 ?  214 ASN   A N   1 
ATOM   1636 C CA  . ASN   A 1 214 ? 15.84707  34.88237 -15.18972 1.000 28.47154 ?  214 ASN   A CA  1 
ATOM   1637 C C   . ASN   A 1 214 ? 15.95542  35.67470 -13.89027 1.000 28.99936 ?  214 ASN   A C   1 
ATOM   1638 O O   . ASN   A 1 214 ? 15.12557  36.55800 -13.64284 1.000 32.01500 ?  214 ASN   A O   1 
ATOM   1639 C CB  . ASN   A 1 214 ? 14.38464  34.67027 -15.56254 1.000 29.67562 ?  214 ASN   A CB  1 
ATOM   1640 C CG  . ASN   A 1 214 ? 14.21437  34.51615 -17.04873 1.000 32.29595 ?  214 ASN   A CG  1 
ATOM   1641 O OD1 . ASN   A 1 214 ? 14.07577  35.51028 -17.75670 1.000 38.55620 ?  214 ASN   A OD1 1 
ATOM   1642 N ND2 . ASN   A 1 214 ? 14.31016  33.27844 -17.54857 1.000 30.23069 ?  214 ASN   A ND2 1 
ATOM   1643 N N   . GLY   A 1 215 ? 16.95243  35.38151 -13.05338 1.000 34.13319 ?  215 GLY   A N   1 
ATOM   1644 C CA  . GLY   A 1 215 ? 17.22694  36.17053 -11.87443 1.000 33.74607 ?  215 GLY   A CA  1 
ATOM   1645 C C   . GLY   A 1 215 ? 16.66271  35.63102 -10.57519 1.000 33.20841 ?  215 GLY   A C   1 
ATOM   1646 O O   . GLY   A 1 215 ? 17.19125  35.96818 -9.51131  1.000 36.52312 ?  215 GLY   A O   1 
ATOM   1647 N N   . ASP   A 1 216 ? 15.62233  34.79970 -10.62768 1.000 32.12206 ?  216 ASP   A N   1 
ATOM   1648 C CA  . ASP   A 1 216 ? 14.95652  34.28839 -9.42587  1.000 28.14962 ?  216 ASP   A CA  1 
ATOM   1649 C C   . ASP   A 1 216 ? 15.76410  33.13566 -8.84572  1.000 27.23728 ?  216 ASP   A C   1 
ATOM   1650 O O   . ASP   A 1 216 ? 15.56813  31.98100 -9.22524  1.000 32.10687 ?  216 ASP   A O   1 
ATOM   1651 C CB  . ASP   A 1 216 ? 13.53889  33.83540 -9.75793  1.000 29.38009 ?  216 ASP   A CB  1 
ATOM   1652 C CG  . ASP   A 1 216 ? 12.49052  34.68024 -9.07375  1.000 38.59613 ?  216 ASP   A CG  1 
ATOM   1653 O OD1 . ASP   A 1 216 ? 12.82419  35.25105 -8.00617  1.000 38.13765 ?  216 ASP   A OD1 1 
ATOM   1654 O OD2 . ASP   A 1 216 ? 11.34306  34.76784 -9.58806  1.000 34.10822 -1 216 ASP   A OD2 1 
ATOM   1655 N N   . ARG   A 1 217 ? 16.64363  33.43477 -7.88099  1.000 25.27254 ?  217 ARG   A N   1 
ATOM   1656 C CA  . ARG   A 1 217 ? 17.64749  32.48316 -7.40813  1.000 26.69246 ?  217 ARG   A CA  1 
ATOM   1657 C C   . ARG   A 1 217 ? 17.59761  32.21355 -5.90382  1.000 23.69392 ?  217 ARG   A C   1 
ATOM   1658 O O   . ARG   A 1 217 ? 18.43542  31.45105 -5.40156  1.000 26.40506 ?  217 ARG   A O   1 
ATOM   1659 C CB  . ARG   A 1 217 ? 19.05544  32.97751 -7.78221  1.000 31.04983 ?  217 ARG   A CB  1 
ATOM   1660 C CG  . ARG   A 1 217 ? 19.40192  34.30657 -7.10308  1.000 41.10382 ?  217 ARG   A CG  1 
ATOM   1661 C CD  . ARG   A 1 217 ? 20.56028  35.06753 -7.76102  1.000 38.60319 ?  217 ARG   A CD  1 
ATOM   1662 N NE  . ARG   A 1 217 ? 20.90938  36.25898 -6.98535  1.000 37.31442 ?  217 ARG   A NE  1 
ATOM   1663 C CZ  . ARG   A 1 217 ? 21.55232  36.22730 -5.82189  1.000 41.88157 ?  217 ARG   A CZ  1 
ATOM   1664 N NH1 . ARG   A 1 217 ? 21.90945  35.07883 -5.26294  1.000 42.60431 ?  217 ARG   A NH1 1 
ATOM   1665 N NH2 . ARG   A 1 217 ? 21.84903  37.37497 -5.20281  1.000 35.20881 ?  217 ARG   A NH2 1 
ATOM   1666 N N   . TRP   A 1 218 ? 16.62915  32.78215 -5.17499  1.000 27.09016 ?  218 TRP   A N   1 
ATOM   1667 C CA  . TRP   A 1 218 ? 16.61859  32.68023 -3.71086  1.000 23.49319 ?  218 TRP   A CA  1 
ATOM   1668 C C   . TRP   A 1 218 ? 16.40925  31.25582 -3.21534  1.000 25.12266 ?  218 TRP   A C   1 
ATOM   1669 O O   . TRP   A 1 218 ? 16.82541  30.93807 -2.09678  1.000 31.71682 ?  218 TRP   A O   1 
ATOM   1670 C CB  . TRP   A 1 218 ? 15.52475  33.57304 -3.10738  1.000 25.77151 ?  218 TRP   A CB  1 
ATOM   1671 C CG  . TRP   A 1 218 ? 14.13115  33.21019 -3.55480  1.000 29.68457 ?  218 TRP   A CG  1 
ATOM   1672 C CD1 . TRP   A 1 218 ? 13.44607  33.74164 -4.61963  1.000 30.11352 ?  218 TRP   A CD1 1 
ATOM   1673 C CD2 . TRP   A 1 218 ? 13.25856  32.22617 -2.96989  1.000 27.74330 ?  218 TRP   A CD2 1 
ATOM   1674 N NE1 . TRP   A 1 218 ? 12.20426  33.16357 -4.72157  1.000 25.65686 ?  218 TRP   A NE1 1 
ATOM   1675 C CE2 . TRP   A 1 218 ? 12.06442  32.22761 -3.72224  1.000 33.53730 ?  218 TRP   A CE2 1 
ATOM   1676 C CE3 . TRP   A 1 218 ? 13.36888  31.35184 -1.88193  1.000 29.07569 ?  218 TRP   A CE3 1 
ATOM   1677 C CZ2 . TRP   A 1 218 ? 10.98574  31.37381 -3.41755  1.000 33.14591 ?  218 TRP   A CZ2 1 
ATOM   1678 C CZ3 . TRP   A 1 218 ? 12.29401  30.52039 -1.57416  1.000 28.03095 ?  218 TRP   A CZ3 1 
ATOM   1679 C CH2 . TRP   A 1 218 ? 11.12445  30.53495 -2.33741  1.000 30.96544 ?  218 TRP   A CH2 1 
ATOM   1680 N N   . PHE   A 1 219 ? 15.76122  30.38866 -3.99788  1.000 22.60206 ?  219 PHE   A N   1 
ATOM   1681 C CA  . PHE   A 1 219 ? 15.49283  29.04349 -3.49299  1.000 24.01277 ?  219 PHE   A CA  1 
ATOM   1682 C C   . PHE   A 1 219 ? 16.69522  28.10959 -3.57053  1.000 23.62707 ?  219 PHE   A C   1 
ATOM   1683 O O   . PHE   A 1 219 ? 16.62265  26.98655 -3.05403  1.000 25.34030 ?  219 PHE   A O   1 
ATOM   1684 C CB  . PHE   A 1 219 ? 14.33660  28.41699 -4.24878  1.000 19.61772 ?  219 PHE   A CB  1 
ATOM   1685 C CG  . PHE   A 1 219 ? 14.48676  28.52393 -5.73124  1.000 18.83300 ?  219 PHE   A CG  1 
ATOM   1686 C CD1 . PHE   A 1 219 ? 15.17089  27.55540 -6.45029  1.000 18.59154 ?  219 PHE   A CD1 1 
ATOM   1687 C CD2 . PHE   A 1 219 ? 13.97463  29.61048 -6.39940  1.000 19.65073 ?  219 PHE   A CD2 1 
ATOM   1688 C CE1 . PHE   A 1 219 ? 15.33534  27.66931 -7.81167  1.000 19.72670 ?  219 PHE   A CE1 1 
ATOM   1689 C CE2 . PHE   A 1 219 ? 14.13006  29.72740 -7.75151  1.000 18.99409 ?  219 PHE   A CE2 1 
ATOM   1690 C CZ  . PHE   A 1 219 ? 14.81156  28.75581 -8.46613  1.000 18.79983 ?  219 PHE   A CZ  1 
ATOM   1691 N N   . LEU   A 1 220 ? 17.78044  28.51498 -4.21595  1.000 23.98442 ?  220 LEU   A N   1 
ATOM   1692 C CA  . LEU   A 1 220 ? 18.94495  27.64722 -4.28804  1.000 23.77357 ?  220 LEU   A CA  1 
ATOM   1693 C C   . LEU   A 1 220 ? 19.59012  27.50690 -2.91361  1.000 29.91928 ?  220 LEU   A C   1 
ATOM   1694 O O   . LEU   A 1 220 ? 19.78743  28.49841 -2.20645  1.000 31.29753 ?  220 LEU   A O   1 
ATOM   1695 C CB  . LEU   A 1 220 ? 19.94878  28.20571 -5.28379  1.000 27.01913 ?  220 LEU   A CB  1 
ATOM   1696 C CG  . LEU   A 1 220 ? 19.50766  28.20730 -6.74557  1.000 32.09946 ?  220 LEU   A CG  1 
ATOM   1697 C CD1 . LEU   A 1 220 ? 20.49667  29.02133 -7.57213  1.000 28.66408 ?  220 LEU   A CD1 1 
ATOM   1698 C CD2 . LEU   A 1 220 ? 19.39042  26.77207 -7.27279  1.000 25.48879 ?  220 LEU   A CD2 1 
ATOM   1699 N N   . ASN   A 1 221 ? 19.91462  26.27803 -2.52870  1.000 33.95334 ?  221 ASN   A N   1 
ATOM   1700 C CA  . ASN   A 1 221 ? 20.58548  26.02814 -1.25984  1.000 34.20354 ?  221 ASN   A CA  1 
ATOM   1701 C C   . ASN   A 1 221 ? 21.95100  25.38863 -1.51363  1.000 36.76384 ?  221 ASN   A C   1 
ATOM   1702 O O   . ASN   A 1 221 ? 22.33702  25.11508 -2.65425  1.000 31.19157 ?  221 ASN   A O   1 
ATOM   1703 C CB  . ASN   A 1 221 ? 19.69794  25.18415 -0.33364  1.000 32.03212 ?  221 ASN   A CB  1 
ATOM   1704 C CG  . ASN   A 1 221 ? 19.33219  23.82929 -0.91781  1.000 35.66428 ?  221 ASN   A CG  1 
ATOM   1705 O OD1 . ASN   A 1 221 ? 20.06833  23.25584 -1.71407  1.000 30.89738 ?  221 ASN   A OD1 1 
ATOM   1706 N ND2 . ASN   A 1 221 ? 18.19126  23.29655 -0.48748  1.000 35.20362 ?  221 ASN   A ND2 1 
ATOM   1707 N N   . ARG   A 1 222 ? 22.69956  25.16892 -0.43463  1.000 38.29000 ?  222 ARG   A N   1 
ATOM   1708 C CA  . ARG   A 1 222 ? 24.07840  24.71651 -0.56007  1.000 31.67230 ?  222 ARG   A CA  1 
ATOM   1709 C C   . ARG   A 1 222 ? 24.20394  23.20342 -0.63990  1.000 33.28997 ?  222 ARG   A C   1 
ATOM   1710 O O   . ARG   A 1 222 ? 25.32268  22.69969 -0.75785  1.000 41.27854 ?  222 ARG   A O   1 
ATOM   1711 C CB  . ARG   A 1 222 ? 24.91561  25.24176 0.61472   1.000 43.36614 ?  222 ARG   A CB  1 
ATOM   1712 C CG  . ARG   A 1 222 ? 24.79827  24.40106 1.88797   1.000 45.17933 ?  222 ARG   A CG  1 
ATOM   1713 C CD  . ARG   A 1 222 ? 25.01696  25.22616 3.16498   1.000 48.28043 ?  222 ARG   A CD  1 
ATOM   1714 N NE  . ARG   A 1 222 ? 24.78992  24.42376 4.36575   1.000 58.09220 ?  222 ARG   A NE  1 
ATOM   1715 C CZ  . ARG   A 1 222 ? 23.93354  24.72305 5.33760   1.000 55.84201 ?  222 ARG   A CZ  1 
ATOM   1716 N NH1 . ARG   A 1 222 ? 23.23641  25.85113 5.32592   1.000 56.37441 ?  222 ARG   A NH1 1 
ATOM   1717 N NH2 . ARG   A 1 222 ? 23.78301  23.87344 6.35463   1.000 47.76688 ?  222 ARG   A NH2 1 
ATOM   1718 N N   . PHE   A 1 223 ? 23.09672  22.47027 -0.60993  1.000 33.86774 ?  223 PHE   A N   1 
ATOM   1719 C CA  . PHE   A 1 223 ? 23.10842  21.02068 -0.48158  1.000 33.59491 ?  223 PHE   A CA  1 
ATOM   1720 C C   . PHE   A 1 223 ? 22.95745  20.30809 -1.82326  1.000 35.70409 ?  223 PHE   A C   1 
ATOM   1721 O O   . PHE   A 1 223 ? 22.51368  20.87321 -2.83188  1.000 33.84029 ?  223 PHE   A O   1 
ATOM   1722 C CB  . PHE   A 1 223 ? 21.98142  20.54762 0.43806   1.000 35.65712 ?  223 PHE   A CB  1 
ATOM   1723 C CG  . PHE   A 1 223 ? 21.92188  21.26148 1.75334   1.000 39.94851 ?  223 PHE   A CG  1 
ATOM   1724 C CD1 . PHE   A 1 223 ? 22.95621  21.13582 2.67945   1.000 41.19694 ?  223 PHE   A CD1 1 
ATOM   1725 C CD2 . PHE   A 1 223 ? 20.81846  22.03340 2.07872   1.000 36.69882 ?  223 PHE   A CD2 1 
ATOM   1726 C CE1 . PHE   A 1 223 ? 22.89497  21.78096 3.91046   1.000 37.25107 ?  223 PHE   A CE1 1 
ATOM   1727 C CE2 . PHE   A 1 223 ? 20.74893  22.67723 3.29788   1.000 47.42976 ?  223 PHE   A CE2 1 
ATOM   1728 C CZ  . PHE   A 1 223 ? 21.79436  22.55114 4.21917   1.000 44.81364 ?  223 PHE   A CZ  1 
ATOM   1729 N N   . THR   A 1 224 ? 23.32806  19.03568 -1.81061  1.000 32.56633 ?  224 THR   A N   1 
ATOM   1730 C CA  . THR   A 1 224 ? 23.02237  18.10473 -2.88153  1.000 35.07252 ?  224 THR   A CA  1 
ATOM   1731 C C   . THR   A 1 224 ? 22.08565  17.04590 -2.31740  1.000 32.47080 ?  224 THR   A C   1 
ATOM   1732 O O   . THR   A 1 224 ? 21.68540  17.10490 -1.15519  1.000 33.13796 ?  224 THR   A O   1 
ATOM   1733 C CB  . THR   A 1 224 ? 24.30839  17.50088 -3.47248  1.000 35.87425 ?  224 THR   A CB  1 
ATOM   1734 O OG1 . THR   A 1 224 ? 24.00484  16.75287 -4.65757  1.000 35.15109 ?  224 THR   A OG1 1 
ATOM   1735 C CG2 . THR   A 1 224 ? 25.01508  16.58828 -2.46099  1.000 32.86976 ?  224 THR   A CG2 1 
ATOM   1736 N N   . THR   A 1 225 ? 21.71012  16.08400 -3.15204  1.000 36.01981 ?  225 THR   A N   1 
ATOM   1737 C CA  . THR   A 1 225 ? 20.94014  14.94322 -2.67485  1.000 30.79201 ?  225 THR   A CA  1 
ATOM   1738 C C   . THR   A 1 225 ? 21.16694  13.79047 -3.63695  1.000 29.62603 ?  225 THR   A C   1 
ATOM   1739 O O   . THR   A 1 225 ? 21.92576  13.89512 -4.60386  1.000 35.47778 ?  225 THR   A O   1 
ATOM   1740 C CB  . THR   A 1 225 ? 19.43970  15.26639 -2.53928  1.000 31.48780 ?  225 THR   A CB  1 
ATOM   1741 O OG1 . THR   A 1 225 ? 18.76341  14.15221 -1.94586  1.000 29.99659 ?  225 THR   A OG1 1 
ATOM   1742 C CG2 . THR   A 1 225 ? 18.81090  15.54622 -3.91250  1.000 32.02547 ?  225 THR   A CG2 1 
ATOM   1743 N N   . THR   A 1 226 ? 20.51442  12.67978 -3.34936  1.000 27.65263 ?  226 THR   A N   1 
ATOM   1744 C CA  . THR   A 1 226 ? 20.54890  11.53658 -4.24131  1.000 30.78432 ?  226 THR   A CA  1 
ATOM   1745 C C   . THR   A 1 226 ? 19.16564  11.34206 -4.83982  1.000 30.19004 ?  226 THR   A C   1 
ATOM   1746 O O   . THR   A 1 226 ? 18.15624  11.72873 -4.24336  1.000 31.63788 ?  226 THR   A O   1 
ATOM   1747 C CB  . THR   A 1 226 ? 20.99196  10.26398 -3.51051  1.000 39.77622 ?  226 THR   A CB  1 
ATOM   1748 O OG1 . THR   A 1 226 ? 19.92203  9.78079  -2.68343  1.000 32.55941 ?  226 THR   A OG1 1 
ATOM   1749 C CG2 . THR   A 1 226 ? 22.23124  10.55456 -2.65169  1.000 30.46308 ?  226 THR   A CG2 1 
ATOM   1750 N N   . LEU   A 1 227 ? 19.13028  10.75254 -6.03615  1.000 33.00429 ?  227 LEU   A N   1 
ATOM   1751 C CA  . LEU   A 1 227 ? 17.85253  10.48597 -6.68218  1.000 32.34444 ?  227 LEU   A CA  1 
ATOM   1752 C C   . LEU   A 1 227 ? 16.91663  9.73463  -5.74430  1.000 34.95365 ?  227 LEU   A C   1 
ATOM   1753 O O   . LEU   A 1 227 ? 15.73666  10.08747 -5.61795  1.000 32.71558 ?  227 LEU   A O   1 
ATOM   1754 C CB  . LEU   A 1 227 ? 18.09901  9.70113  -7.97071  1.000 31.74157 ?  227 LEU   A CB  1 
ATOM   1755 C CG  . LEU   A 1 227 ? 17.09462  9.83704  -9.10455  1.000 35.53618 ?  227 LEU   A CG  1 
ATOM   1756 C CD1 . LEU   A 1 227 ? 16.63844  11.29475 -9.27960  1.000 35.64396 ?  227 LEU   A CD1 1 
ATOM   1757 C CD2 . LEU   A 1 227 ? 17.74556  9.34104  -10.36256 1.000 34.99653 ?  227 LEU   A CD2 1 
ATOM   1758 N N   . ASN   A 1 228 ? 17.45435  8.74039  -5.03119  1.000 37.72039 ?  228 ASN   A N   1 
ATOM   1759 C CA  . ASN   A 1 228 ? 16.66290  7.90903  -4.13061  1.000 40.20289 ?  228 ASN   A CA  1 
ATOM   1760 C C   . ASN   A 1 228 ? 16.03155  8.73418  -3.01990  1.000 31.72437 ?  228 ASN   A C   1 
ATOM   1761 O O   . ASN   A 1 228 ? 14.82137  8.64993  -2.77497  1.000 27.97324 ?  228 ASN   A O   1 
ATOM   1762 C CB  . ASN   A 1 228 ? 17.54471  6.80708  -3.54583  1.000 41.42516 ?  228 ASN   A CB  1 
ATOM   1763 C CG  . ASN   A 1 228 ? 16.93733  5.44831  -3.71793  1.000 51.50448 ?  228 ASN   A CG  1 
ATOM   1764 O OD1 . ASN   A 1 228 ? 16.58407  5.05397  -4.83479  1.000 54.37768 ?  228 ASN   A OD1 1 
ATOM   1765 N ND2 . ASN   A 1 228 ? 16.83303  4.70614  -2.62969  1.000 56.64375 ?  228 ASN   A ND2 1 
ATOM   1766 N N   . ASP   A 1 229 ? 16.83648  9.55048  -2.34422  1.000 34.89642 ?  229 ASP   A N   1 
ATOM   1767 C CA  . ASP   A 1 229 ? 16.30261  10.33471 -1.23393  1.000 36.20006 ?  229 ASP   A CA  1 
ATOM   1768 C C   . ASP   A 1 229 ? 15.33535  11.40981 -1.71827  1.000 34.80843 ?  229 ASP   A C   1 
ATOM   1769 O O   . ASP   A 1 229 ? 14.31595  11.68234 -1.06013  1.000 34.25000 ?  229 ASP   A O   1 
ATOM   1770 C CB  . ASP   A 1 229 ? 17.44202  10.96356 -0.43202  1.000 39.63889 ?  229 ASP   A CB  1 
ATOM   1771 C CG  . ASP   A 1 229 ? 18.17652  9.94774  0.44367   1.000 54.24137 ?  229 ASP   A CG  1 
ATOM   1772 O OD1 . ASP   A 1 229 ? 18.86287  9.05516  -0.11312  1.000 57.34976 -1 229 ASP   A OD1 1 
ATOM   1773 O OD2 . ASP   A 1 229 ? 18.07015  10.05334 1.69222   1.000 65.50179 ?  229 ASP   A OD2 1 
ATOM   1774 N N   . PHE   A 1 230 ? 15.60963  12.00510 -2.88039  1.000 31.99315 ?  230 PHE   A N   1 
ATOM   1775 C CA  . PHE   A 1 230 ? 14.65637  12.96247 -3.42500  1.000 29.23824 ?  230 PHE   A CA  1 
ATOM   1776 C C   . PHE   A 1 230 ? 13.31350  12.29882 -3.71159  1.000 26.94061 ?  230 PHE   A C   1 
ATOM   1777 O O   . PHE   A 1 230 ? 12.26066  12.86060 -3.39002  1.000 24.31210 ?  230 PHE   A O   1 
ATOM   1778 C CB  . PHE   A 1 230 ? 15.19299  13.62672 -4.70005  1.000 26.30442 ?  230 PHE   A CB  1 
ATOM   1779 C CG  . PHE   A 1 230 ? 14.16735  14.48451 -5.38198  1.000 25.70331 ?  230 PHE   A CG  1 
ATOM   1780 C CD1 . PHE   A 1 230 ? 13.94692  15.78892 -4.95125  1.000 23.47162 ?  230 PHE   A CD1 1 
ATOM   1781 C CD2 . PHE   A 1 230 ? 13.37065  13.96723 -6.40885  1.000 24.18707 ?  230 PHE   A CD2 1 
ATOM   1782 C CE1 . PHE   A 1 230 ? 12.97562  16.58447 -5.55491  1.000 26.20027 ?  230 PHE   A CE1 1 
ATOM   1783 C CE2 . PHE   A 1 230 ? 12.39266  14.75164 -7.01624  1.000 25.52100 ?  230 PHE   A CE2 1 
ATOM   1784 C CZ  . PHE   A 1 230 ? 12.19376  16.07101 -6.59562  1.000 26.32636 ?  230 PHE   A CZ  1 
ATOM   1785 N N   . ASN   A 1 231 ? 13.32825  11.12970 -4.36003  1.000 24.19471 ?  231 ASN   A N   1 
ATOM   1786 C CA  . ASN   A 1 231 ? 12.07108  10.47485 -4.72714  1.000 28.12608 ?  231 ASN   A CA  1 
ATOM   1787 C C   . ASN   A 1 231 ? 11.31136  10.01448 -3.49733  1.000 36.78534 ?  231 ASN   A C   1 
ATOM   1788 O O   . ASN   A 1 231 ? 10.06676  10.02957 -3.48907  1.000 31.52965 ?  231 ASN   A O   1 
ATOM   1789 C CB  . ASN   A 1 231 ? 12.32287  9.27370  -5.63972  1.000 22.94042 ?  231 ASN   A CB  1 
ATOM   1790 C CG  . ASN   A 1 231 ? 12.54076  9.67020  -7.08674  1.000 30.55066 ?  231 ASN   A CG  1 
ATOM   1791 O OD1 . ASN   A 1 231 ? 11.92989  10.61624 -7.58787  1.000 27.12387 ?  231 ASN   A OD1 1 
ATOM   1792 N ND2 . ASN   A 1 231 ? 13.41373  8.93330  -7.77634  1.000 30.41687 ?  231 ASN   A ND2 1 
ATOM   1793 N N   . LEU   A 1 232 ? 12.04058  9.61428  -2.44792  1.000 37.25601 ?  232 LEU   A N   1 
ATOM   1794 C CA  . LEU   A 1 232 ? 11.37734  9.30453  -1.18440  1.000 38.04503 ?  232 LEU   A CA  1 
ATOM   1795 C C   . LEU   A 1 232 ? 10.64381  10.52538 -0.64618  1.000 36.22129 ?  232 LEU   A C   1 
ATOM   1796 O O   . LEU   A 1 232 ? 9.46794   10.43545 -0.28666  1.000 38.67685 ?  232 LEU   A O   1 
ATOM   1797 C CB  . LEU   A 1 232 ? 12.38924  8.77838  -0.15086  1.000 37.57769 ?  232 LEU   A CB  1 
ATOM   1798 C CG  . LEU   A 1 232 ? 12.54925  7.25254  -0.12153  1.000 42.76976 ?  232 LEU   A CG  1 
ATOM   1799 C CD1 . LEU   A 1 232 ? 11.25296  6.58470  0.31433   1.000 44.79976 ?  232 LEU   A CD1 1 
ATOM   1800 C CD2 . LEU   A 1 232 ? 13.00608  6.66072  -1.45686  1.000 48.72753 ?  232 LEU   A CD2 1 
ATOM   1801 N N   . VAL   A 1 233 ? 11.30244  11.68882 -0.61257  1.000 34.25225 ?  233 VAL   A N   1 
ATOM   1802 C CA  . VAL   A 1 233 ? 10.61424  12.87417 -0.09176  1.000 33.86205 ?  233 VAL   A CA  1 
ATOM   1803 C C   . VAL   A 1 233 ? 9.44872   13.26807 -0.99301  1.000 35.83781 ?  233 VAL   A C   1 
ATOM   1804 O O   . VAL   A 1 233 ? 8.36561   13.61491 -0.51280  1.000 39.65976 ?  233 VAL   A O   1 
ATOM   1805 C CB  . VAL   A 1 233 ? 11.59194  14.05240 0.10612   1.000 40.41559 ?  233 VAL   A CB  1 
ATOM   1806 C CG1 . VAL   A 1 233 ? 10.82093  15.33477 0.42644   1.000 35.84080 ?  233 VAL   A CG1 1 
ATOM   1807 C CG2 . VAL   A 1 233 ? 12.57924  13.74351 1.21514   1.000 37.00465 ?  233 VAL   A CG2 1 
ATOM   1808 N N   . ALA   A 1 234 ? 9.64427   13.22325 -2.31119  1.000 38.24677 ?  234 ALA   A N   1 
ATOM   1809 C CA  . ALA   A 1 234 ? 8.66348   13.79245 -3.22418  1.000 35.24237 ?  234 ALA   A CA  1 
ATOM   1810 C C   . ALA   A 1 234 ? 7.43854   12.90592 -3.41359  1.000 38.12607 ?  234 ALA   A C   1 
ATOM   1811 O O   . ALA   A 1 234 ? 6.38719   13.40459 -3.84488  1.000 33.28279 ?  234 ALA   A O   1 
ATOM   1812 C CB  . ALA   A 1 234 ? 9.31796   14.07411 -4.57579  1.000 31.89378 ?  234 ALA   A CB  1 
ATOM   1813 N N   . MET   A 1 235 ? 7.54546   11.60775 -3.12392  1.000 36.48711 ?  235 MET   A N   1 
ATOM   1814 C CA  . MET   A 1 235 ? 6.38437   10.73317 -3.27406  1.000 33.70037 ?  235 MET   A CA  1 
ATOM   1815 C C   . MET   A 1 235 ? 5.19129   11.21879 -2.44896  1.000 32.22872 ?  235 MET   A C   1 
ATOM   1816 O O   . MET   A 1 235 ? 4.04718   11.20578 -2.92691  1.000 27.38692 ?  235 MET   A O   1 
ATOM   1817 C CB  . MET   A 1 235 ? 6.77358   9.31349  -2.87471  1.000 37.50671 ?  235 MET   A CB  1 
ATOM   1818 C CG  . MET   A 1 235 ? 5.62113   8.33934  -2.74809  1.000 46.92115 ?  235 MET   A CG  1 
ATOM   1819 S SD  . MET   A 1 235 ? 6.10012   6.96088  -1.68699  1.000 73.55796 ?  235 MET   A SD  1 
ATOM   1820 C CE  . MET   A 1 235 ? 7.77652   6.66473  -2.25810  1.000 52.45879 ?  235 MET   A CE  1 
ATOM   1821 N N   . LYS   A 1 236 ? 5.43258   11.66628 -1.21486  1.000 30.21845 ?  236 LYS   A N   1 
ATOM   1822 C CA  . LYS   A 1 236 ? 4.31060   12.01148 -0.35017  1.000 32.66045 ?  236 LYS   A CA  1 
ATOM   1823 C C   . LYS   A 1 236 ? 3.57059   13.25012 -0.83376  1.000 34.25267 ?  236 LYS   A C   1 
ATOM   1824 O O   . LYS   A 1 236 ? 2.39919   13.42770 -0.48504  1.000 34.67689 ?  236 LYS   A O   1 
ATOM   1825 C CB  . LYS   A 1 236 ? 4.77846   12.20650 1.09311   1.000 30.58627 ?  236 LYS   A CB  1 
ATOM   1826 C CG  . LYS   A 1 236 ? 5.31700   13.58473 1.39884   1.000 37.37184 ?  236 LYS   A CG  1 
ATOM   1827 C CD  . LYS   A 1 236 ? 5.68450   13.73206 2.87967   1.000 40.57330 ?  236 LYS   A CD  1 
ATOM   1828 C CE  . LYS   A 1 236 ? 7.03010   13.07079 3.20476   1.000 41.13348 ?  236 LYS   A CE  1 
ATOM   1829 N NZ  . LYS   A 1 236 ? 8.13456   13.62696 2.36027   1.000 49.72976 ?  236 LYS   A NZ  1 
ATOM   1830 N N   . TYR   A 1 237 ? 4.20751   14.08798 -1.65641  1.000 31.65272 ?  237 TYR   A N   1 
ATOM   1831 C CA  . TYR   A 1 237 ? 3.58884   15.29458 -2.18908  1.000 23.29154 ?  237 TYR   A CA  1 
ATOM   1832 C C   . TYR   A 1 237 ? 2.96625   15.07565 -3.55259  1.000 26.11200 ?  237 TYR   A C   1 
ATOM   1833 O O   . TYR   A 1 237 ? 2.66466   16.04847 -4.25312  1.000 27.36894 ?  237 TYR   A O   1 
ATOM   1834 C CB  . TYR   A 1 237 ? 4.61857   16.41770 -2.26161  1.000 29.24108 ?  237 TYR   A CB  1 
ATOM   1835 C CG  . TYR   A 1 237 ? 5.14455   16.80081 -0.89932  1.000 26.88923 ?  237 TYR   A CG  1 
ATOM   1836 C CD1 . TYR   A 1 237 ? 4.39148   17.60029 -0.04869  1.000 24.82734 ?  237 TYR   A CD1 1 
ATOM   1837 C CD2 . TYR   A 1 237 ? 6.38112   16.35828 -0.46643  1.000 26.90690 ?  237 TYR   A CD2 1 
ATOM   1838 C CE1 . TYR   A 1 237 ? 4.86914   17.95779 1.21768   1.000 33.30554 ?  237 TYR   A CE1 1 
ATOM   1839 C CE2 . TYR   A 1 237 ? 6.86529   16.70367 0.78511   1.000 31.47187 ?  237 TYR   A CE2 1 
ATOM   1840 C CZ  . TYR   A 1 237 ? 6.10769   17.50405 1.62356   1.000 31.91963 ?  237 TYR   A CZ  1 
ATOM   1841 O OH  . TYR   A 1 237 ? 6.60798   17.84708 2.85960   1.000 38.98663 ?  237 TYR   A OH  1 
ATOM   1842 N N   . ASN   A 1 238 ? 2.78376   13.82047 -3.94833  1.000 29.51190 ?  238 ASN   A N   1 
ATOM   1843 C CA  . ASN   A 1 238 ? 2.10467   13.48412 -5.19672  1.000 28.80395 ?  238 ASN   A CA  1 
ATOM   1844 C C   . ASN   A 1 238 ? 2.89724   14.00142 -6.40188  1.000 27.86458 ?  238 ASN   A C   1 
ATOM   1845 O O   . ASN   A 1 238 ? 2.33551   14.50968 -7.37440  1.000 24.38032 ?  238 ASN   A O   1 
ATOM   1846 C CB  . ASN   A 1 238 ? 0.66027   14.00774 -5.19193  1.000 23.71945 ?  238 ASN   A CB  1 
ATOM   1847 C CG  . ASN   A 1 238 ? -0.20110  13.38762 -6.29266  1.000 32.32152 ?  238 ASN   A CG  1 
ATOM   1848 O OD1 . ASN   A 1 238 ? 0.11207   12.31988 -6.82103  1.000 33.33258 ?  238 ASN   A OD1 1 
ATOM   1849 N ND2 . ASN   A 1 238 ? -1.28411  14.07473 -6.65588  1.000 34.04622 ?  238 ASN   A ND2 1 
ATOM   1850 N N   . TYR   A 1 239 ? 4.22142   13.87409 -6.32529  1.000 26.97479 ?  239 TYR   A N   1 
ATOM   1851 C CA  . TYR   A 1 239 ? 5.12440   14.15618 -7.43571  1.000 23.48854 ?  239 TYR   A CA  1 
ATOM   1852 C C   . TYR   A 1 239 ? 5.48881   12.83843 -8.08959  1.000 30.01692 ?  239 TYR   A C   1 
ATOM   1853 O O   . TYR   A 1 239 ? 5.82341   11.87826 -7.39243  1.000 28.01839 ?  239 TYR   A O   1 
ATOM   1854 C CB  . TYR   A 1 239 ? 6.40613   14.85952 -6.96058  1.000 21.89400 ?  239 TYR   A CB  1 
ATOM   1855 C CG  . TYR   A 1 239 ? 6.30247   16.36192 -6.95206  1.000 23.23309 ?  239 TYR   A CG  1 
ATOM   1856 C CD1 . TYR   A 1 239 ? 5.29108   16.99724 -6.24448  1.000 25.21673 ?  239 TYR   A CD1 1 
ATOM   1857 C CD2 . TYR   A 1 239 ? 7.19714   17.14040 -7.66545  1.000 21.26734 ?  239 TYR   A CD2 1 
ATOM   1858 C CE1 . TYR   A 1 239 ? 5.16591   18.37504 -6.24370  1.000 28.64405 ?  239 TYR   A CE1 1 
ATOM   1859 C CE2 . TYR   A 1 239 ? 7.09333   18.52352 -7.66718  1.000 20.78146 ?  239 TYR   A CE2 1 
ATOM   1860 C CZ  . TYR   A 1 239 ? 6.07896   19.13130 -6.95973  1.000 24.30789 ?  239 TYR   A CZ  1 
ATOM   1861 O OH  . TYR   A 1 239 ? 5.95151   20.48931 -6.95172  1.000 24.36223 ?  239 TYR   A OH  1 
ATOM   1862 N N   . GLU   A 1 240 ? 5.45977   12.79414 -9.41639  1.000 29.52172 ?  240 GLU   A N   1 
ATOM   1863 C CA  . GLU   A 1 240 ? 5.84277   11.56290 -10.07754 1.000 24.76209 ?  240 GLU   A CA  1 
ATOM   1864 C C   . GLU   A 1 240 ? 7.33312   11.28991 -9.87851  1.000 26.17531 ?  240 GLU   A C   1 
ATOM   1865 O O   . GLU   A 1 240 ? 8.14170   12.22239 -9.75796  1.000 22.57369 ?  240 GLU   A O   1 
ATOM   1866 C CB  . GLU   A 1 240 ? 5.48158   11.61695 -11.55644 1.000 30.06046 ?  240 GLU   A CB  1 
ATOM   1867 C CG  . GLU   A 1 240 ? 6.39928   12.38625 -12.44943 1.000 31.26696 ?  240 GLU   A CG  1 
ATOM   1868 C CD  . GLU   A 1 240 ? 5.81238   12.46192 -13.85983 1.000 42.71818 ?  240 GLU   A CD  1 
ATOM   1869 O OE1 . GLU   A 1 240 ? 4.56991   12.31194 -13.95526 1.000 38.58985 ?  240 GLU   A OE1 1 
ATOM   1870 O OE2 . GLU   A 1 240 ? 6.56904   12.65879 -14.85408 1.000 39.48300 -1 240 GLU   A OE2 1 
ATOM   1871 N N   . PRO   A 1 241 ? 7.71175   10.01726 -9.77866  1.000 21.38261 ?  241 PRO   A N   1 
ATOM   1872 C CA  . PRO   A 1 241 ? 9.11236   9.67926  -9.51947  1.000 24.59906 ?  241 PRO   A CA  1 
ATOM   1873 C C   . PRO   A 1 241 ? 10.02707  10.23084 -10.59861 1.000 28.22784 ?  241 PRO   A C   1 
ATOM   1874 O O   . PRO   A 1 241 ? 9.69320   10.23103 -11.78736 1.000 24.08728 ?  241 PRO   A O   1 
ATOM   1875 C CB  . PRO   A 1 241 ? 9.12242   8.14304  -9.52690  1.000 26.03762 ?  241 PRO   A CB  1 
ATOM   1876 C CG  . PRO   A 1 241 ? 7.69347   7.72990  -9.37853  1.000 31.26949 ?  241 PRO   A CG  1 
ATOM   1877 C CD  . PRO   A 1 241 ? 6.87851   8.82118  -9.99322  1.000 28.11931 ?  241 PRO   A CD  1 
ATOM   1878 N N   . LEU   A 1 242 ? 11.20449  10.67425 -10.17568 1.000 27.94172 ?  242 LEU   A N   1 
ATOM   1879 C CA  . LEU   A 1 242 ? 12.19234  11.21655 -11.09320 1.000 30.41700 ?  242 LEU   A CA  1 
ATOM   1880 C C   . LEU   A 1 242 ? 13.14362  10.09486 -11.49994 1.000 29.47847 ?  242 LEU   A C   1 
ATOM   1881 O O   . LEU   A 1 242 ? 13.85433  9.54584  -10.65416 1.000 31.52757 ?  242 LEU   A O   1 
ATOM   1882 C CB  . LEU   A 1 242 ? 12.94549  12.37911 -10.44564 1.000 26.45153 ?  242 LEU   A CB  1 
ATOM   1883 C CG  . LEU   A 1 242 ? 13.82008  13.21674 -11.38903 1.000 25.68940 ?  242 LEU   A CG  1 
ATOM   1884 C CD1 . LEU   A 1 242 ? 12.97514  14.03083 -12.35421 1.000 25.05328 ?  242 LEU   A CD1 1 
ATOM   1885 C CD2 . LEU   A 1 242 ? 14.74666  14.12817 -10.60182 1.000 21.06929 ?  242 LEU   A CD2 1 
ATOM   1886 N N   . THR   A 1 243 ? 13.14236  9.74992  -12.78519 1.000 28.71387 ?  243 THR   A N   1 
ATOM   1887 C CA  . THR   A 1 243 ? 13.98910  8.69151  -13.30944 1.000 28.86368 ?  243 THR   A CA  1 
ATOM   1888 C C   . THR   A 1 243 ? 15.33215  9.24643  -13.78355 1.000 31.00276 ?  243 THR   A C   1 
ATOM   1889 O O   . THR   A 1 243 ? 15.54254  10.46066 -13.88808 1.000 26.61286 ?  243 THR   A O   1 
ATOM   1890 C CB  . THR   A 1 243 ? 13.29666  7.98228  -14.46712 1.000 25.56104 ?  243 THR   A CB  1 
ATOM   1891 O OG1 . THR   A 1 243 ? 13.34768  8.82973  -15.62174 1.000 27.91715 ?  243 THR   A OG1 1 
ATOM   1892 C CG2 . THR   A 1 243 ? 11.84170  7.71247  -14.13878 1.000 28.02654 ?  243 THR   A CG2 1 
ATOM   1893 N N   . GLN   A 1 244 ? 16.24500  8.32582  -14.10181 1.000 28.86502 ?  244 GLN   A N   1 
ATOM   1894 C CA  . GLN   A 1 244 ? 17.53899  8.73341  -14.63113 1.000 24.22125 ?  244 GLN   A CA  1 
ATOM   1895 C C   . GLN   A 1 244 ? 17.41973  9.27446  -16.05606 1.000 25.16336 ?  244 GLN   A C   1 
ATOM   1896 O O   . GLN   A 1 244 ? 18.20187  10.14030 -16.45464 1.000 27.86744 ?  244 GLN   A O   1 
ATOM   1897 C CB  . GLN   A 1 244 ? 18.52020  7.55979  -14.56213 1.000 28.38713 ?  244 GLN   A CB  1 
ATOM   1898 C CG  . GLN   A 1 244 ? 19.92424  7.88984  -15.06264 1.000 26.29976 ?  244 GLN   A CG  1 
ATOM   1899 C CD  . GLN   A 1 244 ? 20.66667  8.87327  -14.17761 1.000 26.80767 ?  244 GLN   A CD  1 
ATOM   1900 O OE1 . GLN   A 1 244 ? 20.56683  8.81191  -12.95184 1.000 28.98008 ?  244 GLN   A OE1 1 
ATOM   1901 N NE2 . GLN   A 1 244 ? 21.42725  9.79080  -14.79603 1.000 21.39155 ?  244 GLN   A NE2 1 
ATOM   1902 N N   . ASP   A 1 245 ? 16.45034  8.79826  -16.83378 1.000 22.79608 ?  245 ASP   A N   1 
ATOM   1903 C CA  . ASP   A 1 245 ? 16.15578  9.44296  -18.11079 1.000 23.21497 ?  245 ASP   A CA  1 
ATOM   1904 C C   . ASP   A 1 245 ? 15.77253  10.90447 -17.92235 1.000 27.25677 ?  245 ASP   A C   1 
ATOM   1905 O O   . ASP   A 1 245 ? 16.14893  11.76502 -18.72780 1.000 23.16077 ?  245 ASP   A O   1 
ATOM   1906 C CB  . ASP   A 1 245 ? 15.02538  8.71465  -18.82836 1.000 25.53171 ?  245 ASP   A CB  1 
ATOM   1907 C CG  . ASP   A 1 245 ? 15.49394  7.44723  -19.52410 1.000 34.00403 ?  245 ASP   A CG  1 
ATOM   1908 O OD1 . ASP   A 1 245 ? 16.67415  7.07655  -19.36069 1.000 31.24610 ?  245 ASP   A OD1 1 
ATOM   1909 O OD2 . ASP   A 1 245 ? 14.67604  6.83321  -20.23997 1.000 33.02608 -1 245 ASP   A OD2 1 
ATOM   1910 N N   . HIS   A 1 246 ? 14.98316  11.19622 -16.88875 1.000 23.04343 ?  246 HIS   A N   1 
ATOM   1911 C CA  . HIS   A 1 246 ? 14.61933  12.57903 -16.61117 1.000 24.75914 ?  246 HIS   A CA  1 
ATOM   1912 C C   . HIS   A 1 246 ? 15.84818  13.41326 -16.28613 1.000 24.35922 ?  246 HIS   A C   1 
ATOM   1913 O O   . HIS   A 1 246 ? 15.97811  14.55490 -16.74796 1.000 21.20185 ?  246 HIS   A O   1 
ATOM   1914 C CB  . HIS   A 1 246 ? 13.62777  12.62610 -15.45252 1.000 26.61221 ?  246 HIS   A CB  1 
ATOM   1915 C CG  . HIS   A 1 246 ? 12.28475  12.07295 -15.79494 1.000 22.92622 ?  246 HIS   A CG  1 
ATOM   1916 N ND1 . HIS   A 1 246 ? 11.49448  11.41578 -14.87806 1.000 26.05087 ?  246 HIS   A ND1 1 
ATOM   1917 C CD2 . HIS   A 1 246 ? 11.59371  12.07778 -16.95544 1.000 23.19413 ?  246 HIS   A CD2 1 
ATOM   1918 C CE1 . HIS   A 1 246 ? 10.37079  11.04010 -15.46120 1.000 27.91018 ?  246 HIS   A CE1 1 
ATOM   1919 N NE2 . HIS   A 1 246 ? 10.40504  11.43231 -16.72035 1.000 26.60878 ?  246 HIS   A NE2 1 
ATOM   1920 N N   . VAL   A 1 247 ? 16.74805  12.86411 -15.47022 1.000 21.61095 ?  247 VAL   A N   1 
ATOM   1921 C CA  . VAL   A 1 247 ? 17.98675  13.55898 -15.15638 1.000 22.02638 ?  247 VAL   A CA  1 
ATOM   1922 C C   . VAL   A 1 247 ? 18.77092  13.83306 -16.43239 1.000 22.53317 ?  247 VAL   A C   1 
ATOM   1923 O O   . VAL   A 1 247 ? 19.29095  14.93744 -16.63448 1.000 25.22151 ?  247 VAL   A O   1 
ATOM   1924 C CB  . VAL   A 1 247 ? 18.80797  12.74498 -14.14325 1.000 20.35097 ?  247 VAL   A CB  1 
ATOM   1925 C CG1 . VAL   A 1 247 ? 20.18710  13.34066 -13.98889 1.000 22.60653 ?  247 VAL   A CG1 1 
ATOM   1926 C CG2 . VAL   A 1 247 ? 18.09139  12.66543 -12.80548 1.000 20.58043 ?  247 VAL   A CG2 1 
ATOM   1927 N N   . ASP   A 1 248 ? 18.86416  12.83782 -17.31492 1.000 23.26631 ?  248 ASP   A N   1 
ATOM   1928 C CA  . ASP   A 1 248 ? 19.64623  13.00852 -18.53180 1.000 21.38591 ?  248 ASP   A CA  1 
ATOM   1929 C C   . ASP   A 1 248 ? 19.02447  14.06610 -19.42058 1.000 24.11623 ?  248 ASP   A C   1 
ATOM   1930 O O   . ASP   A 1 248 ? 19.73808  14.82536 -20.08178 1.000 23.27921 ?  248 ASP   A O   1 
ATOM   1931 C CB  . ASP   A 1 248 ? 19.75169  11.68290 -19.27524 1.000 23.50716 ?  248 ASP   A CB  1 
ATOM   1932 C CG  . ASP   A 1 248 ? 20.67286  10.68823 -18.56543 1.000 29.93057 ?  248 ASP   A CG  1 
ATOM   1933 O OD1 . ASP   A 1 248 ? 21.32454  11.09704 -17.57636 1.000 25.38893 ?  248 ASP   A OD1 1 
ATOM   1934 O OD2 . ASP   A 1 248 ? 20.75319  9.51609  -19.00953 1.000 31.70187 -1 248 ASP   A OD2 1 
ATOM   1935 N N   . ILE   A 1 249 ? 17.68845  14.12569 -19.43389 1.000 20.91210 ?  249 ILE   A N   1 
ATOM   1936 C CA  . ILE   A 1 249 ? 16.96674  15.12102 -20.21847 1.000 22.14666 ?  249 ILE   A CA  1 
ATOM   1937 C C   . ILE   A 1 249 ? 17.24660  16.52465 -19.69426 1.000 21.02020 ?  249 ILE   A C   1 
ATOM   1938 O O   . ILE   A 1 249 ? 17.39400  17.46982 -20.47747 1.000 21.69165 ?  249 ILE   A O   1 
ATOM   1939 C CB  . ILE   A 1 249 ? 15.47097  14.76550 -20.21954 1.000 25.45741 ?  249 ILE   A CB  1 
ATOM   1940 C CG1 . ILE   A 1 249 ? 15.22499  13.55510 -21.14167 1.000 24.83630 ?  249 ILE   A CG1 1 
ATOM   1941 C CG2 . ILE   A 1 249 ? 14.61063  15.94613 -20.62755 1.000 24.04786 ?  249 ILE   A CG2 1 
ATOM   1942 C CD1 . ILE   A 1 249 ? 13.85933  12.89950 -20.92287 1.000 27.98446 ?  249 ILE   A CD1 1 
ATOM   1943 N N   . LEU   A 1 250 ? 17.37660  16.67641 -18.37023 1.000 17.36085 ?  250 LEU   A N   1 
ATOM   1944 C CA  . LEU   A 1 250 ? 17.71772  17.95623 -17.74744 1.000 19.15350 ?  250 LEU   A CA  1 
ATOM   1945 C C   . LEU   A 1 250 ? 19.19528  18.31561 -17.87243 1.000 20.46183 ?  250 LEU   A C   1 
ATOM   1946 O O   . LEU   A 1 250 ? 19.56767  19.44850 -17.54145 1.000 20.68752 ?  250 LEU   A O   1 
ATOM   1947 C CB  . LEU   A 1 250 ? 17.32702  17.94832 -16.25743 1.000 17.38211 ?  250 LEU   A CB  1 
ATOM   1948 C CG  . LEU   A 1 250 ? 15.81144  18.00541 -15.99211 1.000 20.36068 ?  250 LEU   A CG  1 
ATOM   1949 C CD1 . LEU   A 1 250 ? 15.46723  17.58971 -14.56626 1.000 16.33123 ?  250 LEU   A CD1 1 
ATOM   1950 C CD2 . LEU   A 1 250 ? 15.24850  19.40977 -16.30297 1.000 16.82791 ?  250 LEU   A CD2 1 
ATOM   1951 N N   . GLY   A 1 251 ? 20.02988  17.38497 -18.32497 1.000 19.13137 ?  251 GLY   A N   1 
ATOM   1952 C CA  . GLY   A 1 251 ? 21.45794  17.58707 -18.44155 1.000 21.85934 ?  251 GLY   A CA  1 
ATOM   1953 C C   . GLY   A 1 251 ? 21.90984  18.89165 -19.08213 1.000 21.18963 ?  251 GLY   A C   1 
ATOM   1954 O O   . GLY   A 1 251 ? 22.71558  19.62827 -18.50706 1.000 22.74842 ?  251 GLY   A O   1 
ATOM   1955 N N   . PRO   A 1 252 ? 21.42943  19.19878 -20.29189 1.000 22.53710 ?  252 PRO   A N   1 
ATOM   1956 C CA  . PRO   A 1 252 ? 21.87955  20.44652 -20.94221 1.000 25.05830 ?  252 PRO   A CA  1 
ATOM   1957 C C   . PRO   A 1 252 ? 21.54698  21.69373 -20.14733 1.000 21.72175 ?  252 PRO   A C   1 
ATOM   1958 O O   . PRO   A 1 252 ? 22.34857  22.63296 -20.12355 1.000 22.24596 ?  252 PRO   A O   1 
ATOM   1959 C CB  . PRO   A 1 252 ? 21.14341  20.42244 -22.29011 1.000 22.15380 ?  252 PRO   A CB  1 
ATOM   1960 C CG  . PRO   A 1 252 ? 20.93992  18.96065 -22.55393 1.000 28.15682 ?  252 PRO   A CG  1 
ATOM   1961 C CD  . PRO   A 1 252 ? 20.60945  18.38019 -21.20409 1.000 24.02062 ?  252 PRO   A CD  1 
ATOM   1962 N N   . LEU   A 1 253 ? 20.37882  21.73504 -19.49859 1.000 19.25539 ?  253 LEU   A N   1 
ATOM   1963 C CA  . LEU   A 1 253 ? 20.05888  22.87812 -18.64837 1.000 21.73031 ?  253 LEU   A CA  1 
ATOM   1964 C C   . LEU   A 1 253 ? 21.04132  22.98596 -17.49204 1.000 21.48583 ?  253 LEU   A C   1 
ATOM   1965 O O   . LEU   A 1 253 ? 21.52746  24.08344 -17.17508 1.000 25.23574 ?  253 LEU   A O   1 
ATOM   1966 C CB  . LEU   A 1 253 ? 18.62158  22.77806 -18.12062 1.000 23.66481 ?  253 LEU   A CB  1 
ATOM   1967 C CG  . LEU   A 1 253 ? 17.53572  23.36041 -19.01819 1.000 21.60022 ?  253 LEU   A CG  1 
ATOM   1968 C CD1 . LEU   A 1 253 ? 16.13822  23.10518 -18.43288 1.000 24.78633 ?  253 LEU   A CD1 1 
ATOM   1969 C CD2 . LEU   A 1 253 ? 17.75120  24.87424 -19.22879 1.000 21.12652 ?  253 LEU   A CD2 1 
ATOM   1970 N N   . SER   A 1 254 ? 21.35590  21.85949 -16.85151 1.000 21.34814 ?  254 SER   A N   1 
ATOM   1971 C CA  . SER   A 1 254 ? 22.28265  21.92166 -15.72620 1.000 25.31271 ?  254 SER   A CA  1 
ATOM   1972 C C   . SER   A 1 254 ? 23.65577  22.36609 -16.18995 1.000 26.30452 ?  254 SER   A C   1 
ATOM   1973 O O   . SER   A 1 254 ? 24.35473  23.07917 -15.46323 1.000 25.34758 ?  254 SER   A O   1 
ATOM   1974 C CB  . SER   A 1 254 ? 22.36847  20.57267 -15.00997 1.000 26.59961 ?  254 SER   A CB  1 
ATOM   1975 O OG  . SER   A 1 254 ? 22.88777  19.57347 -15.85517 1.000 28.32164 ?  254 SER   A OG  1 
ATOM   1976 N N   . ALA   A 1 255 ? 24.03704  21.98846 -17.41310 1.000 20.80409 ?  255 ALA   A N   1 
ATOM   1977 C CA  . ALA   A 1 255 ? 25.31674  22.42064 -17.95663 1.000 29.83478 ?  255 ALA   A CA  1 
ATOM   1978 C C   . ALA   A 1 255 ? 25.30568  23.91167 -18.29759 1.000 30.46931 ?  255 ALA   A C   1 
ATOM   1979 O O   . ALA   A 1 255 ? 26.28469  24.62366 -18.04453 1.000 33.02531 ?  255 ALA   A O   1 
ATOM   1980 C CB  . ALA   A 1 255 ? 25.66548  21.58031 -19.19077 1.000 23.89692 ?  255 ALA   A CB  1 
ATOM   1981 N N   . GLN   A 1 256 ? 24.21107  24.40906 -18.86764 1.000 25.05268 ?  256 GLN   A N   1 
ATOM   1982 C CA  . GLN   A 1 256 ? 24.15771  25.82348 -19.22245 1.000 27.40041 ?  256 GLN   A CA  1 
ATOM   1983 C C   . GLN   A 1 256 ? 24.19026  26.71935 -17.98213 1.000 32.15809 ?  256 GLN   A C   1 
ATOM   1984 O O   . GLN   A 1 256 ? 24.85984  27.76809 -17.97619 1.000 32.46694 ?  256 GLN   A O   1 
ATOM   1985 C CB  . GLN   A 1 256 ? 22.91340  26.10716 -20.06138 1.000 22.46626 ?  256 GLN   A CB  1 
ATOM   1986 C CG  . GLN   A 1 256 ? 22.58742  27.59551 -20.14122 1.000 31.86976 ?  256 GLN   A CG  1 
ATOM   1987 C CD  . GLN   A 1 256 ? 21.22951  27.88609 -20.76991 1.000 33.67852 ?  256 GLN   A CD  1 
ATOM   1988 O OE1 . GLN   A 1 256 ? 20.56276  26.98305 -21.27918 1.000 32.15050 ?  256 GLN   A OE1 1 
ATOM   1989 N NE2 . GLN   A 1 256 ? 20.81931  29.15647 -20.74119 1.000 32.99049 ?  256 GLN   A NE2 1 
ATOM   1990 N N   . THR   A 1 257 ? 23.47405  26.33524 -16.92186 1.000 29.28073 ?  257 THR   A N   1 
ATOM   1991 C CA  . THR   A 1 257 ? 23.45969  27.15767 -15.71543 1.000 26.42517 ?  257 THR   A CA  1 
ATOM   1992 C C   . THR   A 1 257 ? 24.55642  26.80424 -14.72361 1.000 28.84472 ?  257 THR   A C   1 
ATOM   1993 O O   . THR   A 1 257 ? 24.75590  27.54614 -13.75660 1.000 29.08252 ?  257 THR   A O   1 
ATOM   1994 C CB  . THR   A 1 257 ? 22.13049  27.02518 -15.00289 1.000 27.08917 ?  257 THR   A CB  1 
ATOM   1995 O OG1 . THR   A 1 257 ? 22.02611  25.67913 -14.53962 1.000 25.56399 ?  257 THR   A OG1 1 
ATOM   1996 C CG2 . THR   A 1 257 ? 20.97482  27.36568 -15.95586 1.000 20.34352 ?  257 THR   A CG2 1 
ATOM   1997 N N   . GLY   A 1 258 ? 25.24528  25.68322 -14.90906 1.000 27.22484 ?  258 GLY   A N   1 
ATOM   1998 C CA  . GLY   A 1 258 ? 26.23525  25.29083 -13.92619 1.000 23.75174 ?  258 GLY   A CA  1 
ATOM   1999 C C   . GLY   A 1 258 ? 25.67250  24.85873 -12.59073 1.000 26.73804 ?  258 GLY   A C   1 
ATOM   2000 O O   . GLY   A 1 258 ? 26.39709  24.88286 -11.59420 1.000 23.14689 ?  258 GLY   A O   1 
ATOM   2001 N N   . ILE   A 1 259 ? 24.40029  24.46093 -12.53301 1.000 26.01203 ?  259 ILE   A N   1 
ATOM   2002 C CA  . ILE   A 1 259 ? 23.80117  23.89249 -11.32375 1.000 25.96854 ?  259 ILE   A CA  1 
ATOM   2003 C C   . ILE   A 1 259 ? 23.48082  22.43536 -11.61058 1.000 26.68252 ?  259 ILE   A C   1 
ATOM   2004 O O   . ILE   A 1 259 ? 22.68518  22.13965 -12.50894 1.000 22.37460 ?  259 ILE   A O   1 
ATOM   2005 C CB  . ILE   A 1 259 ? 22.53465  24.65196 -10.89719 1.000 24.08135 ?  259 ILE   A CB  1 
ATOM   2006 C CG1 . ILE   A 1 259 ? 22.87279  26.11508 -10.63320 1.000 28.48708 ?  259 ILE   A CG1 1 
ATOM   2007 C CG2 . ILE   A 1 259 ? 21.88004  23.98503 -9.68808  1.000 22.84899 ?  259 ILE   A CG2 1 
ATOM   2008 C CD1 . ILE   A 1 259 ? 21.65903  27.05327 -10.71382 1.000 27.60593 ?  259 ILE   A CD1 1 
ATOM   2009 N N   . ALA   A 1 260 ? 24.08010  21.52922 -10.83875 1.000 26.21368 ?  260 ALA   A N   1 
ATOM   2010 C CA  . ALA   A 1 260 ? 23.87112  20.10685 -11.05118 1.000 19.60442 ?  260 ALA   A CA  1 
ATOM   2011 C C   . ALA   A 1 260 ? 22.40379  19.75270 -10.85547 1.000 23.71816 ?  260 ALA   A C   1 
ATOM   2012 O O   . ALA   A 1 260 ? 21.69797  20.38131 -10.06667 1.000 24.40480 ?  260 ALA   A O   1 
ATOM   2013 C CB  . ALA   A 1 260 ? 24.73177  19.30180 -10.08346 1.000 20.75073 ?  260 ALA   A CB  1 
ATOM   2014 N N   . VAL   A 1 261 ? 21.94524  18.71630 -11.56557 1.000 20.75296 ?  261 VAL   A N   1 
ATOM   2015 C CA  . VAL   A 1 261 ? 20.53691  18.33542 -11.46813 1.000 23.41093 ?  261 VAL   A CA  1 
ATOM   2016 C C   . VAL   A 1 261 ? 20.18889  17.93107 -10.03817 1.000 23.02057 ?  261 VAL   A C   1 
ATOM   2017 O O   . VAL   A 1 261 ? 19.13415  18.30478 -9.50694  1.000 23.98318 ?  261 VAL   A O   1 
ATOM   2018 C CB  . VAL   A 1 261 ? 20.19877  17.21323 -12.46957 1.000 23.88460 ?  261 VAL   A CB  1 
ATOM   2019 C CG1 . VAL   A 1 261 ? 18.76919  16.77034 -12.30008 1.000 20.83376 ?  261 VAL   A CG1 1 
ATOM   2020 C CG2 . VAL   A 1 261 ? 20.43311  17.66322 -13.90748 1.000 24.46045 ?  261 VAL   A CG2 1 
ATOM   2021 N N   . LEU   A 1 262 ? 21.06763  17.17671 -9.38166  1.000 25.10413 ?  262 LEU   A N   1 
ATOM   2022 C CA  . LEU   A 1 262 ? 20.73341  16.74210 -8.02835  1.000 31.90626 ?  262 LEU   A CA  1 
ATOM   2023 C C   . LEU   A 1 262 ? 20.81773  17.88331 -7.00685  1.000 25.06419 ?  262 LEU   A C   1 
ATOM   2024 O O   . LEU   A 1 262 ? 20.14973  17.82668 -5.96763  1.000 31.61595 ?  262 LEU   A O   1 
ATOM   2025 C CB  . LEU   A 1 262 ? 21.61428  15.55708 -7.62340  1.000 32.07895 ?  262 LEU   A CB  1 
ATOM   2026 C CG  . LEU   A 1 262 ? 21.31339  14.25274 -8.38767  1.000 32.06332 ?  262 LEU   A CG  1 
ATOM   2027 C CD1 . LEU   A 1 262 ? 22.31805  13.15350 -8.03085  1.000 34.37710 ?  262 LEU   A CD1 1 
ATOM   2028 C CD2 . LEU   A 1 262 ? 19.90554  13.76748 -8.15398  1.000 28.28695 ?  262 LEU   A CD2 1 
ATOM   2029 N N   . ASP   A 1 263 ? 21.56135  18.94754 -7.30062  1.000 27.66244 ?  263 ASP   A N   1 
ATOM   2030 C CA  . ASP   A 1 263 ? 21.50916  20.13626 -6.44774  1.000 27.39933 ?  263 ASP   A CA  1 
ATOM   2031 C C   . ASP   A 1 263 ? 20.17479  20.86434 -6.58177  1.000 26.87885 ?  263 ASP   A C   1 
ATOM   2032 O O   . ASP   A 1 263 ? 19.59371  21.32524 -5.58278  1.000 32.55231 ?  263 ASP   A O   1 
ATOM   2033 C CB  . ASP   A 1 263 ? 22.65731  21.08018 -6.79240  1.000 30.02067 ?  263 ASP   A CB  1 
ATOM   2034 C CG  . ASP   A 1 263 ? 24.02878  20.48419 -6.48268  1.000 39.88089 ?  263 ASP   A CG  1 
ATOM   2035 O OD1 . ASP   A 1 263 ? 24.13550  19.23870 -6.30036  1.000 37.35667 ?  263 ASP   A OD1 1 
ATOM   2036 O OD2 . ASP   A 1 263 ? 25.00643  21.27411 -6.43155  1.000 42.94809 -1 263 ASP   A OD2 1 
ATOM   2037 N N   . MET   A 1 264 ? 19.66959  20.99312 -7.81367  1.000 26.81724 ?  264 MET   A N   1 
ATOM   2038 C CA  . MET   A 1 264 ? 18.34191  21.57400 -7.97939  1.000 26.23145 ?  264 MET   A CA  1 
ATOM   2039 C C   . MET   A 1 264 ? 17.29080  20.70503 -7.32379  1.000 24.39282 ?  264 MET   A C   1 
ATOM   2040 O O   . MET   A 1 264 ? 16.29284  21.22895 -6.81681  1.000 25.29052 ?  264 MET   A O   1 
ATOM   2041 C CB  . MET   A 1 264 ? 17.97931  21.75781 -9.46058  1.000 22.70636 ?  264 MET   A CB  1 
ATOM   2042 C CG  . MET   A 1 264 ? 16.73128  22.60855 -9.67246  1.000 17.93411 ?  264 MET   A CG  1 
ATOM   2043 S SD  . MET   A 1 264 ? 17.10387  24.30586 -9.16847  1.000 19.13810 ?  264 MET   A SD  1 
ATOM   2044 C CE  . MET   A 1 264 ? 17.60163  25.04802 -10.75746 1.000 18.67770 ?  264 MET   A CE  1 
ATOM   2045 N N   . CYS   A 1 265 ? 17.47783  19.37540 -7.36377  1.000 23.34623 ?  265 CYS   A N   1 
ATOM   2046 C CA  . CYS   A 1 265 ? 16.56019  18.47262 -6.66958  1.000 23.39942 ?  265 CYS   A CA  1 
ATOM   2047 C C   . CYS   A 1 265 ? 16.58219  18.72755 -5.17030  1.000 28.33060 ?  265 CYS   A C   1 
ATOM   2048 O O   . CYS   A 1 265 ? 15.53207  18.70247 -4.52045  1.000 23.48744 ?  265 CYS   A O   1 
ATOM   2049 C CB  . CYS   A 1 265 ? 16.90601  17.00650 -6.94589  1.000 20.50833 ?  265 CYS   A CB  1 
ATOM   2050 S SG  . CYS   A 1 265 ? 16.53060  16.43941 -8.63099  1.000 23.54958 ?  265 CYS   A SG  1 
ATOM   2051 N N   . ALA   A 1 266 ? 17.77477  18.95676 -4.60070  1.000 25.39423 ?  266 ALA   A N   1 
ATOM   2052 C CA  . ALA   A 1 266 ? 17.86214  19.36727 -3.19516  1.000 29.21638 ?  266 ALA   A CA  1 
ATOM   2053 C C   . ALA   A 1 266 ? 17.05240  20.63433 -2.93612  1.000 25.86829 ?  266 ALA   A C   1 
ATOM   2054 O O   . ALA   A 1 266 ? 16.30970  20.71763 -1.94880  1.000 28.12064 ?  266 ALA   A O   1 
ATOM   2055 C CB  . ALA   A 1 266 ? 19.32380  19.59565 -2.78195  1.000 27.64419 ?  266 ALA   A CB  1 
ATOM   2056 N N   . SER   A 1 267 ? 17.17858  21.63404 -3.82199  1.000 27.99079 ?  267 SER   A N   1 
ATOM   2057 C CA  . SER   A 1 267 ? 16.39391  22.87373 -3.67248  1.000 22.72745 ?  267 SER   A CA  1 
ATOM   2058 C C   . SER   A 1 267 ? 14.88927  22.60579 -3.71934  1.000 24.99973 ?  267 SER   A C   1 
ATOM   2059 O O   . SER   A 1 267 ? 14.11043  23.19565 -2.95299  1.000 25.11630 ?  267 SER   A O   1 
ATOM   2060 C CB  . SER   A 1 267 ? 16.76941  23.89334 -4.75423  1.000 24.30466 ?  267 SER   A CB  1 
ATOM   2061 O OG  . SER   A 1 267 ? 18.03354  24.46803 -4.49420  1.000 34.20363 ?  267 SER   A OG  1 
ATOM   2062 N N   . LEU   A 1 268 ? 14.45535  21.72973 -4.62102  1.000 25.03101 ?  268 LEU   A N   1 
ATOM   2063 C CA  . LEU   A 1 268 ? 13.02900  21.43863 -4.72503  1.000 19.74813 ?  268 LEU   A CA  1 
ATOM   2064 C C   . LEU   A 1 268 ? 12.54060  20.63768 -3.52757  1.000 21.91715 ?  268 LEU   A C   1 
ATOM   2065 O O   . LEU   A 1 268 ? 11.39366  20.79595 -3.10138  1.000 23.15944 ?  268 LEU   A O   1 
ATOM   2066 C CB  . LEU   A 1 268 ? 12.72453  20.67200 -6.01723  1.000 18.16807 ?  268 LEU   A CB  1 
ATOM   2067 C CG  . LEU   A 1 268 ? 11.32195  20.05479 -6.19908  1.000 19.38920 ?  268 LEU   A CG  1 
ATOM   2068 C CD1 . LEU   A 1 268 ? 10.22281  21.11047 -6.10410  1.000 17.41388 ?  268 LEU   A CD1 1 
ATOM   2069 C CD2 . LEU   A 1 268 ? 11.25150  19.36551 -7.55335  1.000 19.91526 ?  268 LEU   A CD2 1 
ATOM   2070 N N   . LYS   A 1 269 ? 13.37913  19.75084 -2.99523  1.000 22.68829 ?  269 LYS   A N   1 
ATOM   2071 C CA  . LYS   A 1 269 ? 13.02054  19.03654 -1.77314  1.000 25.66461 ?  269 LYS   A CA  1 
ATOM   2072 C C   . LYS   A 1 269 ? 12.77305  20.02142 -0.63405  1.000 25.65453 ?  269 LYS   A C   1 
ATOM   2073 O O   . LYS   A 1 269 ? 11.77824  19.91946 0.09609   1.000 28.88522 ?  269 LYS   A O   1 
ATOM   2074 C CB  . LYS   A 1 269 ? 14.13518  18.04823 -1.40888  1.000 24.42629 ?  269 LYS   A CB  1 
ATOM   2075 C CG  . LYS   A 1 269 ? 14.08579  17.56346 0.03237   1.000 35.71917 ?  269 LYS   A CG  1 
ATOM   2076 C CD  . LYS   A 1 269 ? 15.39090  16.88196 0.44303   1.000 39.48518 ?  269 LYS   A CD  1 
ATOM   2077 C CE  . LYS   A 1 269 ? 15.50982  15.49392 -0.17504  1.000 40.45947 ?  269 LYS   A CE  1 
ATOM   2078 N NZ  . LYS   A 1 269 ? 16.87537  14.90922 0.02840   1.000 41.38088 ?  269 LYS   A NZ  1 
ATOM   2079 N N   . GLU   A 1 270 ? 13.66625  20.99680 -0.47442  1.000 23.47486 ?  270 GLU   A N   1 
ATOM   2080 C CA  . GLU   A 1 270 ? 13.42301  22.01871 0.54256   1.000 27.21980 ?  270 GLU   A CA  1 
ATOM   2081 C C   . GLU   A 1 270 ? 12.12926  22.78532 0.26468   1.000 30.77986 ?  270 GLU   A C   1 
ATOM   2082 O O   . GLU   A 1 270 ? 11.34803  23.05058 1.18807   1.000 29.34145 ?  270 GLU   A O   1 
ATOM   2083 C CB  . GLU   A 1 270 ? 14.61140  22.98173 0.63710   1.000 35.51063 ?  270 GLU   A CB  1 
ATOM   2084 C CG  . GLU   A 1 270 ? 14.83910  23.51520 2.05345   1.000 43.17925 ?  270 GLU   A CG  1 
ATOM   2085 C CD  . GLU   A 1 270 ? 15.75940  24.73586 2.09314   1.000 49.55635 ?  270 GLU   A CD  1 
ATOM   2086 O OE1 . GLU   A 1 270 ? 17.00054  24.58090 1.97743   1.000 47.75788 ?  270 GLU   A OE1 1 
ATOM   2087 O OE2 . GLU   A 1 270 ? 15.22980  25.86032 2.23192   1.000 59.94781 -1 270 GLU   A OE2 1 
ATOM   2088 N N   . LEU   A 1 271 ? 11.87690  23.14543 -1.00110  1.000 23.58493 ?  271 LEU   A N   1 
ATOM   2089 C CA  . LEU   A 1 271 ? 10.64614  23.87684 -1.32234  1.000 25.61771 ?  271 LEU   A CA  1 
ATOM   2090 C C   . LEU   A 1 271 ? 9.39465   23.04729 -1.04405  1.000 27.85590 ?  271 LEU   A C   1 
ATOM   2091 O O   . LEU   A 1 271 ? 8.34917   23.59487 -0.66709  1.000 27.33692 ?  271 LEU   A O   1 
ATOM   2092 C CB  . LEU   A 1 271 ? 10.64531  24.31538 -2.79204  1.000 22.43089 ?  271 LEU   A CB  1 
ATOM   2093 C CG  . LEU   A 1 271 ? 11.49450  25.52329 -3.20663  1.000 24.90152 ?  271 LEU   A CG  1 
ATOM   2094 C CD1 . LEU   A 1 271 ? 11.70184  25.53648 -4.71210  1.000 16.99741 ?  271 LEU   A CD1 1 
ATOM   2095 C CD2 . LEU   A 1 271 ? 10.82695  26.80958 -2.77290  1.000 25.67778 ?  271 LEU   A CD2 1 
ATOM   2096 N N   . LEU   A 1 272 ? 9.46476   21.74008 -1.25943  1.000 25.06028 ?  272 LEU   A N   1 
ATOM   2097 C CA  . LEU   A 1 272 ? 8.31892   20.89220 -0.96879  1.000 30.85774 ?  272 LEU   A CA  1 
ATOM   2098 C C   . LEU   A 1 272 ? 8.10994   20.72218 0.53214   1.000 28.62411 ?  272 LEU   A C   1 
ATOM   2099 O O   . LEU   A 1 272 ? 6.96626   20.65749 0.99841   1.000 29.99414 ?  272 LEU   A O   1 
ATOM   2100 C CB  . LEU   A 1 272 ? 8.49816   19.53114 -1.63735  1.000 25.73669 ?  272 LEU   A CB  1 
ATOM   2101 C CG  . LEU   A 1 272 ? 8.33646   19.50509 -3.15569  1.000 24.84801 ?  272 LEU   A CG  1 
ATOM   2102 C CD1 . LEU   A 1 272 ? 8.49803   18.08317 -3.65975  1.000 30.17897 ?  272 LEU   A CD1 1 
ATOM   2103 C CD2 . LEU   A 1 272 ? 6.99418   20.07599 -3.57615  1.000 22.71431 ?  272 LEU   A CD2 1 
ATOM   2104 N N   . GLN   A 1 273 ? 9.18960   20.66971 1.29913   1.000 29.62036 ?  273 GLN   A N   1 
ATOM   2105 C CA  . GLN   A 1 273 ? 9.04378   20.48520 2.73722   1.000 33.71978 ?  273 GLN   A CA  1 
ATOM   2106 C C   . GLN   A 1 273 ? 8.67175   21.76332 3.47428   1.000 33.42426 ?  273 GLN   A C   1 
ATOM   2107 O O   . GLN   A 1 273 ? 7.98855   21.69439 4.49746   1.000 34.79063 ?  273 GLN   A O   1 
ATOM   2108 C CB  . GLN   A 1 273 ? 10.33435  19.90287 3.31300   1.000 29.95220 ?  273 GLN   A CB  1 
ATOM   2109 C CG  . GLN   A 1 273 ? 10.53556  18.46451 2.88225   1.000 31.95917 ?  273 GLN   A CG  1 
ATOM   2110 C CD  . GLN   A 1 273 ? 11.88452  17.92296 3.26448   1.000 39.47515 ?  273 GLN   A CD  1 
ATOM   2111 O OE1 . GLN   A 1 273 ? 12.02585  16.72633 3.51537   1.000 40.31332 ?  273 GLN   A OE1 1 
ATOM   2112 N NE2 . GLN   A 1 273 ? 12.89242  18.79886 3.31490   1.000 41.24576 ?  273 GLN   A NE2 1 
ATOM   2113 N N   . ASN   A 1 274 ? 9.07950   22.92948 2.97563   1.000 34.20518 ?  274 ASN   A N   1 
ATOM   2114 C CA  . ASN   A 1 274 ? 8.92523   24.16213 3.72817   1.000 30.26357 ?  274 ASN   A CA  1 
ATOM   2115 C C   . ASN   A 1 274 ? 8.03287   25.17789 3.05329   1.000 35.05003 ?  274 ASN   A C   1 
ATOM   2116 O O   . ASN   A 1 274 ? 7.77263   26.22929 3.64530   1.000 39.60555 ?  274 ASN   A O   1 
ATOM   2117 C CB  . ASN   A 1 274 ? 10.29532  24.80349 3.99670   1.000 30.02473 ?  274 ASN   A CB  1 
ATOM   2118 C CG  . ASN   A 1 274 ? 11.23000  23.86613 4.70311   1.000 38.96211 ?  274 ASN   A CG  1 
ATOM   2119 O OD1 . ASN   A 1 274 ? 10.78213  22.99237 5.44484   1.000 42.93983 ?  274 ASN   A OD1 1 
ATOM   2120 N ND2 . ASN   A 1 274 ? 12.53666  24.02586 4.47701   1.000 46.06067 ?  274 ASN   A ND2 1 
ATOM   2121 N N   . GLY   A 1 275 ? 7.55111   24.90033 1.85081   1.000 34.60989 ?  275 GLY   A N   1 
ATOM   2122 C CA  . GLY   A 1 275 ? 6.80356   25.89615 1.13403   1.000 34.15196 ?  275 GLY   A CA  1 
ATOM   2123 C C   . GLY   A 1 275 ? 7.68522   27.06523 0.70799   1.000 35.24320 ?  275 GLY   A C   1 
ATOM   2124 O O   . GLY   A 1 275 ? 8.90882   27.08598 0.87581   1.000 32.17518 ?  275 GLY   A O   1 
ATOM   2125 N N   . MET   A 1 276 ? 7.01899   28.05916 0.13879   1.000 37.88392 ?  276 MET   A N   1 
ATOM   2126 C CA  . MET   A 1 276 ? 7.69685   29.22844 -0.38837  1.000 40.42479 ?  276 MET   A CA  1 
ATOM   2127 C C   . MET   A 1 276 ? 7.77206   30.37644 0.60292   1.000 47.96698 ?  276 MET   A C   1 
ATOM   2128 O O   . MET   A 1 276 ? 8.56877   31.29988 0.39492   1.000 46.59134 ?  276 MET   A O   1 
ATOM   2129 C CB  . MET   A 1 276 ? 7.00034   29.70508 -1.66204  1.000 37.17164 ?  276 MET   A CB  1 
ATOM   2130 C CG  . MET   A 1 276 ? 7.37047   28.89062 -2.86779  1.000 38.66643 ?  276 MET   A CG  1 
ATOM   2131 S SD  . MET   A 1 276 ? 6.92875   29.76062 -4.37242  1.000 52.14443 ?  276 MET   A SD  1 
ATOM   2132 C CE  . MET   A 1 276 ? 6.07285   28.44472 -5.22967  1.000 37.54677 ?  276 MET   A CE  1 
ATOM   2133 N N   . ASN   A 1 277 ? 6.96631   30.34358 1.66332   1.000 48.36938 ?  277 ASN   A N   1 
ATOM   2134 C CA  . ASN   A 1 277 ? 7.02499   31.35367 2.71331   1.000 50.31231 ?  277 ASN   A CA  1 
ATOM   2135 C C   . ASN   A 1 277 ? 6.79352   32.74357 2.12891   1.000 46.55425 ?  277 ASN   A C   1 
ATOM   2136 O O   . ASN   A 1 277 ? 7.61518   33.65130 2.27145   1.000 47.12426 ?  277 ASN   A O   1 
ATOM   2137 C CB  . ASN   A 1 277 ? 8.35529   31.27716 3.46387   1.000 49.19044 ?  277 ASN   A CB  1 
ATOM   2138 C CG  . ASN   A 1 277 ? 8.46162   30.03447 4.33466   1.000 58.24519 ?  277 ASN   A CG  1 
ATOM   2139 O OD1 . ASN   A 1 277 ? 9.19157   30.02413 5.32546   1.000 62.16716 ?  277 ASN   A OD1 1 
ATOM   2140 N ND2 . ASN   A 1 277 ? 7.71235   28.98724 3.98329   1.000 49.89060 ?  277 ASN   A ND2 1 
ATOM   2141 N N   . GLY   A 1 278 ? 5.66674   32.88637 1.43127   1.000 48.19469 ?  278 GLY   A N   1 
ATOM   2142 C CA  . GLY   A 1 278 ? 5.26376   34.14250 0.84669   1.000 52.11161 ?  278 GLY   A CA  1 
ATOM   2143 C C   . GLY   A 1 278 ? 6.00610   34.55755 -0.40121  1.000 49.36114 ?  278 GLY   A C   1 
ATOM   2144 O O   . GLY   A 1 278 ? 5.47498   35.37278 -1.17198  1.000 53.71017 ?  278 GLY   A O   1 
ATOM   2145 N N   . ARG   A 1 279 ? 7.21298   34.03578 -0.63441  1.000 45.46746 ?  279 ARG   A N   1 
ATOM   2146 C CA  . ARG   A 1 279 ? 7.97331   34.45427 -1.80601  1.000 44.18146 ?  279 ARG   A CA  1 
ATOM   2147 C C   . ARG   A 1 279 ? 7.39228   33.82652 -3.07196  1.000 40.36206 ?  279 ARG   A C   1 
ATOM   2148 O O   . ARG   A 1 279 ? 6.62943   32.86004 -3.02683  1.000 42.76725 ?  279 ARG   A O   1 
ATOM   2149 C CB  . ARG   A 1 279 ? 9.45274   34.09045 -1.65883  1.000 36.53323 ?  279 ARG   A CB  1 
ATOM   2150 C CG  . ARG   A 1 279 ? 10.09194  34.60849 -0.38855  1.000 40.93830 ?  279 ARG   A CG  1 
ATOM   2151 C CD  . ARG   A 1 279 ? 11.61014  34.68218 -0.50707  1.000 36.86844 ?  279 ARG   A CD  1 
ATOM   2152 N NE  . ARG   A 1 279 ? 11.99865  35.50471 -1.64785  1.000 48.23760 ?  279 ARG   A NE  1 
ATOM   2153 C CZ  . ARG   A 1 279 ? 13.21753  35.98822 -1.85527  1.000 48.74822 ?  279 ARG   A CZ  1 
ATOM   2154 N NH1 . ARG   A 1 279 ? 14.20211  35.77295 -0.99189  1.000 45.89126 ?  279 ARG   A NH1 1 
ATOM   2155 N NH2 . ARG   A 1 279 ? 13.44918  36.71734 -2.94899  1.000 38.45195 ?  279 ARG   A NH2 1 
ATOM   2156 N N   . THR   A 1 280 ? 7.72884   34.41580 -4.21288  1.000 40.05128 ?  280 THR   A N   1 
ATOM   2157 C CA  . THR   A 1 280 ? 7.30275   33.89450 -5.50208  1.000 36.31361 ?  280 THR   A CA  1 
ATOM   2158 C C   . THR   A 1 280 ? 8.50615   33.44689 -6.32149  1.000 36.82452 ?  280 THR   A C   1 
ATOM   2159 O O   . THR   A 1 280 ? 9.65438   33.79943 -6.03294  1.000 29.94253 ?  280 THR   A O   1 
ATOM   2160 C CB  . THR   A 1 280 ? 6.51699   34.92696 -6.30351  1.000 27.91976 ?  280 THR   A CB  1 
ATOM   2161 O OG1 . THR   A 1 280 ? 7.30669   36.11534 -6.43154  1.000 28.84945 ?  280 THR   A OG1 1 
ATOM   2162 C CG2 . THR   A 1 280 ? 5.20075   35.24339 -5.61367  1.000 42.45188 ?  280 THR   A CG2 1 
ATOM   2163 N N   . ILE   A 1 281 ? 8.21456   32.64738 -7.34589  1.000 31.10487 ?  281 ILE   A N   1 
ATOM   2164 C CA  . ILE   A 1 281 ? 9.18900   32.22521 -8.34289  1.000 27.39800 ?  281 ILE   A CA  1 
ATOM   2165 C C   . ILE   A 1 281 ? 8.59674   32.52361 -9.71009  1.000 26.55122 ?  281 ILE   A C   1 
ATOM   2166 O O   . ILE   A 1 281 ? 7.53802   31.98503 -10.06069 1.000 26.61565 ?  281 ILE   A O   1 
ATOM   2167 C CB  . ILE   A 1 281 ? 9.53761   30.73355 -8.22177  1.000 25.50650 ?  281 ILE   A CB  1 
ATOM   2168 C CG1 . ILE   A 1 281 ? 10.10835  30.41024 -6.83346  1.000 24.21199 ?  281 ILE   A CG1 1 
ATOM   2169 C CG2 . ILE   A 1 281 ? 10.51971  30.34752 -9.30808  1.000 23.38124 ?  281 ILE   A CG2 1 
ATOM   2170 C CD1 . ILE   A 1 281 ? 10.52679  28.94594 -6.65477  1.000 20.29527 ?  281 ILE   A CD1 1 
ATOM   2171 N N   . LEU   A 1 282 ? 9.26680   33.38410 -10.47446 1.000 20.93635 ?  282 LEU   A N   1 
ATOM   2172 C CA  . LEU   A 1 282 ? 8.78649   33.80125 -11.78903 1.000 25.66716 ?  282 LEU   A CA  1 
ATOM   2173 C C   . LEU   A 1 282 ? 7.35586   34.33837 -11.71776 1.000 31.00332 ?  282 LEU   A C   1 
ATOM   2174 O O   . LEU   A 1 282 ? 6.53770   34.09358 -12.60540 1.000 30.07170 ?  282 LEU   A O   1 
ATOM   2175 C CB  . LEU   A 1 282 ? 8.88654   32.66098 -12.80439 1.000 19.97073 ?  282 LEU   A CB  1 
ATOM   2176 C CG  . LEU   A 1 282 ? 10.29560  32.27555 -13.24436 1.000 17.98254 ?  282 LEU   A CG  1 
ATOM   2177 C CD1 . LEU   A 1 282 ? 10.26414  31.04029 -14.10530 1.000 21.22337 ?  282 LEU   A CD1 1 
ATOM   2178 C CD2 . LEU   A 1 282 ? 10.94022  33.42523 -14.00055 1.000 20.22831 ?  282 LEU   A CD2 1 
ATOM   2179 N N   . GLY   A 1 283 ? 7.04865   35.06940 -10.64435 1.000 32.09183 ?  283 GLY   A N   1 
ATOM   2180 C CA  . GLY   A 1 283 ? 5.73303   35.64089 -10.45782 1.000 34.27641 ?  283 GLY   A CA  1 
ATOM   2181 C C   . GLY   A 1 283 ? 4.69329   34.72155 -9.84878  1.000 38.89463 ?  283 GLY   A C   1 
ATOM   2182 O O   . GLY   A 1 283 ? 3.63241   35.20776 -9.42944  1.000 41.39476 ?  283 GLY   A O   1 
ATOM   2183 N N   . SER   A 1 284 ? 4.95332   33.41964 -9.76710  1.000 35.85317 ?  284 SER   A N   1 
ATOM   2184 C CA  . SER   A 1 284 ? 3.95346   32.45411 -9.33289  1.000 33.35568 ?  284 SER   A CA  1 
ATOM   2185 C C   . SER   A 1 284 ? 4.16082   32.06997 -7.87243  1.000 34.53620 ?  284 SER   A C   1 
ATOM   2186 O O   . SER   A 1 284 ? 5.29015   31.89068 -7.41600  1.000 33.59942 ?  284 SER   A O   1 
ATOM   2187 C CB  . SER   A 1 284 ? 3.99819   31.19862 -10.20856 1.000 34.43327 ?  284 SER   A CB  1 
ATOM   2188 O OG  . SER   A 1 284 ? 3.32749   30.12125 -9.57352  1.000 32.34273 ?  284 SER   A OG  1 
ATOM   2189 N N   . ALA   A 1 285 ? 3.06693   31.94503 -7.13908  1.000 35.96916 ?  285 ALA   A N   1 
ATOM   2190 C CA  . ALA   A 1 285 ? 3.13805   31.45255 -5.77290  1.000 40.28830 ?  285 ALA   A CA  1 
ATOM   2191 C C   . ALA   A 1 285 ? 3.00645   29.93893 -5.70432  1.000 33.79668 ?  285 ALA   A C   1 
ATOM   2192 O O   . ALA   A 1 285 ? 2.99333   29.37497 -4.61074  1.000 38.12240 ?  285 ALA   A O   1 
ATOM   2193 C CB  . ALA   A 1 285 ? 2.05582   32.11295 -4.91171  1.000 39.61424 ?  285 ALA   A CB  1 
ATOM   2194 N N   . LEU   A 1 286 ? 2.91353   29.26901 -6.84279  1.000 35.64212 ?  286 LEU   A N   1 
ATOM   2195 C CA  . LEU   A 1 286 ? 2.80335   27.82216 -6.91257  1.000 34.24430 ?  286 LEU   A CA  1 
ATOM   2196 C C   . LEU   A 1 286 ? 3.93045   27.28454 -7.78225  1.000 35.14855 ?  286 LEU   A C   1 
ATOM   2197 O O   . LEU   A 1 286 ? 4.45160   27.99440 -8.65105  1.000 29.23519 ?  286 LEU   A O   1 
ATOM   2198 C CB  . LEU   A 1 286 ? 1.44415   27.40375 -7.49998  1.000 33.11086 ?  286 LEU   A CB  1 
ATOM   2199 C CG  . LEU   A 1 286 ? 0.21853   28.05528 -6.85024  1.000 42.55983 ?  286 LEU   A CG  1 
ATOM   2200 C CD1 . LEU   A 1 286 ? -1.07404  27.67227 -7.57243  1.000 37.03932 ?  286 LEU   A CD1 1 
ATOM   2201 C CD2 . LEU   A 1 286 ? 0.14751   27.69344 -5.37149  1.000 40.30647 ?  286 LEU   A CD2 1 
ATOM   2202 N N   . LEU   A 1 287 ? 4.30880   26.02778 -7.54694  1.000 23.31369 ?  287 LEU   A N   1 
ATOM   2203 C CA  . LEU   A 1 287 ? 5.30083   25.38697 -8.39374  1.000 23.94717 ?  287 LEU   A CA  1 
ATOM   2204 C C   . LEU   A 1 287 ? 4.64892   24.97568 -9.70936  1.000 27.12910 ?  287 LEU   A C   1 
ATOM   2205 O O   . LEU   A 1 287 ? 3.63084   24.28627 -9.72049  1.000 30.35412 ?  287 LEU   A O   1 
ATOM   2206 C CB  . LEU   A 1 287 ? 5.91213   24.18825 -7.68234  1.000 23.03375 ?  287 LEU   A CB  1 
ATOM   2207 C CG  . LEU   A 1 287 ? 6.57035   24.54853 -6.34316  1.000 28.34334 ?  287 LEU   A CG  1 
ATOM   2208 C CD1 . LEU   A 1 287 ? 7.01306   23.29358 -5.63284  1.000 21.63131 ?  287 LEU   A CD1 1 
ATOM   2209 C CD2 . LEU   A 1 287 ? 7.75130   25.49999 -6.53593  1.000 25.32518 ?  287 LEU   A CD2 1 
ATOM   2210 N N   . GLU   A 1 288 ? 5.22994   25.40848 -10.81707 1.000 25.73934 ?  288 GLU   A N   1 
ATOM   2211 C CA  . GLU   A 1 288 ? 4.62829   25.24268 -12.13458 1.000 22.23099 ?  288 GLU   A CA  1 
ATOM   2212 C C   . GLU   A 1 288 ? 5.21442   24.00210 -12.79955 1.000 19.83745 ?  288 GLU   A C   1 
ATOM   2213 O O   . GLU   A 1 288 ? 6.43705   23.84732 -12.84129 1.000 20.39461 ?  288 GLU   A O   1 
ATOM   2214 C CB  . GLU   A 1 288 ? 4.90382   26.49643 -12.96469 1.000 24.00440 ?  288 GLU   A CB  1 
ATOM   2215 C CG  . GLU   A 1 288 ? 4.55836   26.38138 -14.42339 1.000 33.50582 ?  288 GLU   A CG  1 
ATOM   2216 C CD  . GLU   A 1 288 ? 3.10607   26.70236 -14.69518 1.000 41.54233 ?  288 GLU   A CD  1 
ATOM   2217 O OE1 . GLU   A 1 288 ? 2.67536   27.80999 -14.28523 1.000 45.82144 ?  288 GLU   A OE1 1 
ATOM   2218 O OE2 . GLU   A 1 288 ? 2.41702   25.84805 -15.31208 1.000 41.27350 -1 288 GLU   A OE2 1 
ATOM   2219 N N   . ASP   A 1 289 ? 4.35359   23.11569 -13.32334 1.000 18.44065 ?  289 ASP   A N   1 
ATOM   2220 C CA  . ASP   A 1 289 ? 4.84749   21.89535 -13.95549 1.000 16.69795 ?  289 ASP   A CA  1 
ATOM   2221 C C   . ASP   A 1 289 ? 4.44085   21.75428 -15.42420 1.000 18.31654 ?  289 ASP   A C   1 
ATOM   2222 O O   . ASP   A 1 289 ? 4.43711   20.63772 -15.94838 1.000 14.64061 ?  289 ASP   A O   1 
ATOM   2223 C CB  . ASP   A 1 289 ? 4.39898   20.65364 -13.17375 1.000 16.09555 ?  289 ASP   A CB  1 
ATOM   2224 C CG  . ASP   A 1 289 ? 2.90982   20.34004 -13.35622 1.000 22.54682 ?  289 ASP   A CG  1 
ATOM   2225 O OD1 . ASP   A 1 289 ? 2.17905   21.16323 -13.94759 1.000 16.80475 ?  289 ASP   A OD1 1 
ATOM   2226 O OD2 . ASP   A 1 289 ? 2.47700   19.26086 -12.89489 1.000 22.87830 -1 289 ASP   A OD2 1 
ATOM   2227 N N   . GLU   A 1 290 ? 4.11039   22.84346 -16.11904 1.000 19.63880 ?  290 GLU   A N   1 
ATOM   2228 C CA  . GLU   A 1 290 ? 3.68673   22.73666 -17.51251 1.000 18.31414 ?  290 GLU   A CA  1 
ATOM   2229 C C   . GLU   A 1 290 ? 4.72470   23.25960 -18.50410 1.000 19.42577 ?  290 GLU   A C   1 
ATOM   2230 O O   . GLU   A 1 290 ? 4.37981   23.52038 -19.66374 1.000 17.36215 ?  290 GLU   A O   1 
ATOM   2231 C CB  . GLU   A 1 290 ? 2.33395   23.44082 -17.72413 1.000 21.46489 ?  290 GLU   A CB  1 
ATOM   2232 C CG  . GLU   A 1 290 ? 1.17303   22.80515 -16.90702 1.000 22.65529 ?  290 GLU   A CG  1 
ATOM   2233 C CD  . GLU   A 1 290 ? -0.08151  22.44992 -17.72659 1.000 28.91976 ?  290 GLU   A CD  1 
ATOM   2234 O OE1 . GLU   A 1 290 ? -0.23268  22.92828 -18.87586 1.000 26.53556 ?  290 GLU   A OE1 1 
ATOM   2235 O OE2 . GLU   A 1 290 ? -0.92872  21.67022 -17.21140 1.000 27.33337 -1 290 GLU   A OE2 1 
ATOM   2236 N N   . PHE   A 1 291 ? 5.98991   23.39296 -18.08752 1.000 15.00145 ?  291 PHE   A N   1 
ATOM   2237 C CA  . PHE   A 1 291 ? 7.10482   23.70238 -18.98760 1.000 19.18234 ?  291 PHE   A CA  1 
ATOM   2238 C C   . PHE   A 1 291 ? 8.02859   22.49615 -19.06133 1.000 19.54075 ?  291 PHE   A C   1 
ATOM   2239 O O   . PHE   A 1 291 ? 8.59470   22.08138 -18.04605 1.000 16.08512 ?  291 PHE   A O   1 
ATOM   2240 C CB  . PHE   A 1 291 ? 7.90357   24.91663 -18.51145 1.000 17.15173 ?  291 PHE   A CB  1 
ATOM   2241 C CG  . PHE   A 1 291 ? 7.12991   26.19267 -18.52771 1.000 22.06320 ?  291 PHE   A CG  1 
ATOM   2242 C CD1 . PHE   A 1 291 ? 7.10209   26.97327 -19.66655 1.000 21.97561 ?  291 PHE   A CD1 1 
ATOM   2243 C CD2 . PHE   A 1 291 ? 6.44195   26.61746 -17.40603 1.000 22.28000 ?  291 PHE   A CD2 1 
ATOM   2244 C CE1 . PHE   A 1 291 ? 6.40657   28.15270 -19.69662 1.000 24.11406 ?  291 PHE   A CE1 1 
ATOM   2245 C CE2 . PHE   A 1 291 ? 5.73622   27.81069 -17.42709 1.000 28.42661 ?  291 PHE   A CE2 1 
ATOM   2246 C CZ  . PHE   A 1 291 ? 5.71805   28.57597 -18.57364 1.000 27.24076 ?  291 PHE   A CZ  1 
ATOM   2247 N N   . THR   A 1 292 ? 8.22494   21.95782 -20.25170 1.000 16.25552 ?  292 THR   A N   1 
ATOM   2248 C CA  . THR   A 1 292 ? 9.16651   20.86821 -20.36772 1.000 18.98284 ?  292 THR   A CA  1 
ATOM   2249 C C   . THR   A 1 292 ? 10.58621  21.42536 -20.40499 1.000 22.71100 ?  292 THR   A C   1 
ATOM   2250 O O   . THR   A 1 292 ? 10.79262  22.62615 -20.63048 1.000 20.42813 ?  292 THR   A O   1 
ATOM   2251 C CB  . THR   A 1 292 ? 8.90479   20.03236 -21.61736 1.000 21.00511 ?  292 THR   A CB  1 
ATOM   2252 O OG1 . THR   A 1 292 ? 9.24521   20.78803 -22.78450 1.000 20.92440 ?  292 THR   A OG1 1 
ATOM   2253 C CG2 . THR   A 1 292 ? 7.45154   19.57677 -21.67436 1.000 21.13671 ?  292 THR   A CG2 1 
ATOM   2254 N N   . PRO   A 1 293 ? 11.57870  20.57942 -20.14505 1.000 16.44858 ?  293 PRO   A N   1 
ATOM   2255 C CA  . PRO   A 1 293 ? 12.96434  20.99743 -20.37970 1.000 20.78261 ?  293 PRO   A CA  1 
ATOM   2256 C C   . PRO   A 1 293 ? 13.16766  21.59419 -21.76006 1.000 25.07479 ?  293 PRO   A C   1 
ATOM   2257 O O   . PRO   A 1 293 ? 13.89640  22.59514 -21.91849 1.000 19.09768 ?  293 PRO   A O   1 
ATOM   2258 C CB  . PRO   A 1 293 ? 13.73882  19.68580 -20.20227 1.000 18.48432 ?  293 PRO   A CB  1 
ATOM   2259 C CG  . PRO   A 1 293 ? 12.93157  18.92959 -19.19128 1.000 19.23482 ?  293 PRO   A CG  1 
ATOM   2260 C CD  . PRO   A 1 293 ? 11.49932  19.22793 -19.55734 1.000 18.00878 ?  293 PRO   A CD  1 
ATOM   2261 N N   . PHE   A 1 294 ? 12.51718  21.01428 -22.77278 1.000 21.99227 ?  294 PHE   A N   1 
ATOM   2262 C CA  . PHE   A 1 294 ? 12.70653  21.54189 -24.11418 1.000 26.45407 ?  294 PHE   A CA  1 
ATOM   2263 C C   . PHE   A 1 294 ? 12.06147  22.91682 -24.25292 1.000 21.13314 ?  294 PHE   A C   1 
ATOM   2264 O O   . PHE   A 1 294 ? 12.62111  23.78708 -24.91502 1.000 25.80542 ?  294 PHE   A O   1 
ATOM   2265 C CB  . PHE   A 1 294 ? 12.18971  20.56122 -25.17600 1.000 30.00891 ?  294 PHE   A CB  1 
ATOM   2266 C CG  . PHE   A 1 294 ? 12.18402  21.14128 -26.57752 1.000 41.92170 ?  294 PHE   A CG  1 
ATOM   2267 C CD1 . PHE   A 1 294 ? 13.37440  21.36299 -27.26343 1.000 41.22976 ?  294 PHE   A CD1 1 
ATOM   2268 C CD2 . PHE   A 1 294 ? 10.98104  21.48128 -27.19928 1.000 45.92144 ?  294 PHE   A CD2 1 
ATOM   2269 C CE1 . PHE   A 1 294 ? 13.36729  21.89171 -28.54328 1.000 42.43976 ?  294 PHE   A CE1 1 
ATOM   2270 C CE2 . PHE   A 1 294 ? 10.96813  22.01773 -28.47845 1.000 48.13636 ?  294 PHE   A CE2 1 
ATOM   2271 C CZ  . PHE   A 1 294 ? 12.16596  22.21916 -29.15089 1.000 45.26375 ?  294 PHE   A CZ  1 
ATOM   2272 N N   . ASP   A 1 295 ? 10.90072  23.14985 -23.61807 1.000 22.07530 ?  295 ASP   A N   1 
ATOM   2273 C CA  . ASP   A 1 295 ? 10.30092  24.49009 -23.64385 1.000 22.03611 ?  295 ASP   A CA  1 
ATOM   2274 C C   . ASP   A 1 295 ? 11.23177  25.52291 -23.03279 1.000 20.09019 ?  295 ASP   A C   1 
ATOM   2275 O O   . ASP   A 1 295 ? 11.36636  26.64414 -23.55263 1.000 21.03777 ?  295 ASP   A O   1 
ATOM   2276 C CB  . ASP   A 1 295 ? 8.97035   24.52590 -22.88501 1.000 19.13498 ?  295 ASP   A CB  1 
ATOM   2277 C CG  . ASP   A 1 295 ? 7.93316   23.59552 -23.47905 1.000 27.93842 ?  295 ASP   A CG  1 
ATOM   2278 O OD1 . ASP   A 1 295 ? 8.08048   23.21081 -24.67317 1.000 28.35638 ?  295 ASP   A OD1 1 
ATOM   2279 O OD2 . ASP   A 1 295 ? 6.96425   23.27030 -22.74295 1.000 23.71268 -1 295 ASP   A OD2 1 
ATOM   2280 N N   . VAL   A 1 296 ? 11.89747  25.15855 -21.93332 1.000 18.57701 ?  296 VAL   A N   1 
ATOM   2281 C CA  . VAL   A 1 296 ? 12.81452  26.10097 -21.30634 1.000 18.56370 ?  296 VAL   A CA  1 
ATOM   2282 C C   . VAL   A 1 296 ? 13.95377  26.42105 -22.26072 1.000 23.51259 ?  296 VAL   A C   1 
ATOM   2283 O O   . VAL   A 1 296 ? 14.27395  27.59116 -22.50036 1.000 23.48036 ?  296 VAL   A O   1 
ATOM   2284 C CB  . VAL   A 1 296 ? 13.34605  25.56231 -19.96442 1.000 14.00099 ?  296 VAL   A CB  1 
ATOM   2285 C CG1 . VAL   A 1 296 ? 14.38463  26.53805 -19.40883 1.000 15.85320 ?  296 VAL   A CG1 1 
ATOM   2286 C CG2 . VAL   A 1 296 ? 12.20599  25.36790 -18.97162 1.000 15.96291 ?  296 VAL   A CG2 1 
ATOM   2287 N N   . VAL   A 1 297 ? 14.61380  25.39161 -22.78795 1.000 19.56915 ?  297 VAL   A N   1 
ATOM   2288 C CA  . VAL   A 1 297 ? 15.73833  25.64882 -23.69293 1.000 24.94570 ?  297 VAL   A CA  1 
ATOM   2289 C C   . VAL   A 1 297 ? 15.28880  26.47593 -24.90043 1.000 28.81340 ?  297 VAL   A C   1 
ATOM   2290 O O   . VAL   A 1 297 ? 15.95155  27.44708 -25.28584 1.000 30.39178 ?  297 VAL   A O   1 
ATOM   2291 C CB  . VAL   A 1 297 ? 16.39597  24.32721 -24.12262 1.000 25.52128 ?  297 VAL   A CB  1 
ATOM   2292 C CG1 . VAL   A 1 297 ? 17.41783  24.57752 -25.24999 1.000 26.56878 ?  297 VAL   A CG1 1 
ATOM   2293 C CG2 . VAL   A 1 297 ? 17.06660  23.66676 -22.91285 1.000 22.14523 ?  297 VAL   A CG2 1 
ATOM   2294 N N   . ARG   A 1 298 ? 14.15785  26.09832 -25.50387 1.000 26.52853 ?  298 ARG   A N   1 
ATOM   2295 C CA  . ARG   A 1 298 ? 13.58725  26.78039 -26.66238 1.000 27.67755 ?  298 ARG   A CA  1 
ATOM   2296 C C   . ARG   A 1 298 ? 13.45505  28.27327 -26.40067 1.000 30.39975 ?  298 ARG   A C   1 
ATOM   2297 O O   . ARG   A 1 298 ? 13.95811  29.10764 -27.16705 1.000 32.94071 ?  298 ARG   A O   1 
ATOM   2298 C CB  . ARG   A 1 298 ? 12.21323  26.13865 -26.94596 1.000 34.93979 ?  298 ARG   A CB  1 
ATOM   2299 C CG  . ARG   A 1 298 ? 11.56423  26.24305 -28.32105 1.000 38.42674 ?  298 ARG   A CG  1 
ATOM   2300 C CD  . ARG   A 1 298 ? 10.08157  25.77042 -28.21843 1.000 38.02393 ?  298 ARG   A CD  1 
ATOM   2301 N NE  . ARG   A 1 298 ? 9.13514   26.87730 -28.39503 1.000 39.17736 ?  298 ARG   A NE  1 
ATOM   2302 C CZ  . ARG   A 1 298 ? 7.90987   26.94941 -27.87733 1.000 41.06333 ?  298 ARG   A CZ  1 
ATOM   2303 N NH1 . ARG   A 1 298 ? 7.42736   25.99059 -27.09340 1.000 36.95884 ?  298 ARG   A NH1 1 
ATOM   2304 N NH2 . ARG   A 1 298 ? 7.15245   28.01667 -28.14893 1.000 34.08976 ?  298 ARG   A NH2 1 
ATOM   2305 N N   . GLN   A 1 299 ? 12.78787  28.62498 -25.30099 1.000 25.02030 ?  299 GLN   A N   1 
ATOM   2306 C CA  . GLN   A 1 299 ? 12.52556  30.02507 -25.01545 1.000 32.97072 ?  299 GLN   A CA  1 
ATOM   2307 C C   . GLN   A 1 299 ? 13.78449  30.76972 -24.58793 1.000 34.04084 ?  299 GLN   A C   1 
ATOM   2308 O O   . GLN   A 1 299 ? 13.94710  31.94648 -24.92853 1.000 34.56250 ?  299 GLN   A O   1 
ATOM   2309 C CB  . GLN   A 1 299 ? 11.45289  30.15378 -23.93451 1.000 21.79479 ?  299 GLN   A CB  1 
ATOM   2310 C CG  . GLN   A 1 299 ? 11.13059  31.58315 -23.59741 1.000 23.64029 ?  299 GLN   A CG  1 
ATOM   2311 C CD  . GLN   A 1 299 ? 9.86858   31.71211 -22.75663 1.000 27.35530 ?  299 GLN   A CD  1 
ATOM   2312 O OE1 . GLN   A 1 299 ? 9.62651   32.75899 -22.17657 1.000 24.17592 ?  299 GLN   A OE1 1 
ATOM   2313 N NE2 . GLN   A 1 299 ? 9.05613   30.64792 -22.69451 1.000 22.94226 ?  299 GLN   A NE2 1 
ATOM   2314 N N   . CYS   A 1 300 ? 14.68407  30.11781 -23.85004 1.000 26.89648 ?  300 CYS   A N   1 
ATOM   2315 C CA  . CYS   A 1 300 ? 15.86081  30.80438 -23.32517 1.000 29.10446 ?  300 CYS   A CA  1 
ATOM   2316 C C   . CYS   A 1 300 ? 17.03979  30.83378 -24.29735 1.000 32.38843 ?  300 CYS   A C   1 
ATOM   2317 O O   . CYS   A 1 300 ? 18.04199  31.48947 -23.99939 1.000 37.49388 ?  300 CYS   A O   1 
ATOM   2318 C CB  . CYS   A 1 300 ? 16.29015  30.17076 -21.99197 1.000 23.60976 ?  300 CYS   A CB  1 
ATOM   2319 S SG  . CYS   A 1 300 ? 15.10154  30.47112 -20.63795 1.000 35.23800 ?  300 CYS   A SG  1 
ATOM   2320 N N   . SER   A 1 301 ? 16.94802  30.16403 -25.44823 1.000 36.13677 ?  301 SER   A N   1 
ATOM   2321 C CA  . SER   A 1 301 ? 17.96878  30.24588 -26.48705 1.000 32.32077 ?  301 SER   A CA  1 
ATOM   2322 C C   . SER   A 1 301 ? 17.46173  30.82612 -27.80769 1.000 34.72261 ?  301 SER   A C   1 
ATOM   2323 O O   . SER   A 1 301 ? 18.26640  31.00340 -28.73040 1.000 35.88357 ?  301 SER   A O   1 
ATOM   2324 C CB  . SER   A 1 301 ? 18.56412  28.85364 -26.75322 1.000 33.91956 ?  301 SER   A CB  1 
ATOM   2325 O OG  . SER   A 1 301 ? 17.58545  28.02264 -27.37299 1.000 34.14601 ?  301 SER   A OG  1 
ATOM   2326 N N   . GLY   A 1 302 ? 16.16373  31.09743 -27.93964 1.000 40.26306 ?  302 GLY   A N   1 
ATOM   2327 C CA  . GLY   A 1 302 ? 15.64600  31.78036 -29.11774 1.000 34.06582 ?  302 GLY   A CA  1 
ATOM   2328 C C   . GLY   A 1 302 ? 15.46925  30.92098 -30.35248 1.000 35.15869 ?  302 GLY   A C   1 
ATOM   2329 O O   . GLY   A 1 302 ? 15.80496  31.35669 -31.46319 1.000 33.76604 ?  302 GLY   A O   1 
ATOM   2330 N N   . VAL   A 1 303 ? 14.94246  29.70665 -30.19268 1.000 31.56873 ?  303 VAL   A N   1 
ATOM   2331 C CA  . VAL   A 1 303 ? 14.76160  28.79900 -31.32002 1.000 34.23595 ?  303 VAL   A CA  1 
ATOM   2332 C C   . VAL   A 1 303 ? 13.59527  29.28555 -32.17102 1.000 33.00246 ?  303 VAL   A C   1 
ATOM   2333 O O   . VAL   A 1 303 ? 12.51787  29.60307 -31.64946 1.000 35.32988 ?  303 VAL   A O   1 
ATOM   2334 C CB  . VAL   A 1 303 ? 14.53740  27.36114 -30.81819 1.000 34.51614 ?  303 VAL   A CB  1 
ATOM   2335 C CG1 . VAL   A 1 303 ? 14.08396  26.44920 -31.95834 1.000 30.87890 ?  303 VAL   A CG1 1 
ATOM   2336 C CG2 . VAL   A 1 303 ? 15.80474  26.82086 -30.16402 1.000 31.40365 ?  303 VAL   A CG2 1 
ATOM   2337 N N   . THR   A 1 304 ? 13.80727  29.35123 -33.48459 1.000 30.03053 ?  304 THR   A N   1 
ATOM   2338 C CA  . THR   A 1 304 ? 12.81658  29.82896 -34.44361 1.000 32.81605 ?  304 THR   A CA  1 
ATOM   2339 C C   . THR   A 1 304 ? 12.42085  28.70366 -35.39574 1.000 36.76340 ?  304 THR   A C   1 
ATOM   2340 O O   . THR   A 1 304 ? 13.04467  27.63658 -35.43354 1.000 35.68089 ?  304 THR   A O   1 
ATOM   2341 C CB  . THR   A 1 304 ? 13.35017  31.02564 -35.24804 1.000 28.67872 ?  304 THR   A CB  1 
ATOM   2342 O OG1 . THR   A 1 304 ? 14.55708  30.63979 -35.91323 1.000 34.95192 ?  304 THR   A OG1 1 
ATOM   2343 C CG2 . THR   A 1 304 ? 13.65764  32.17722 -34.33455 1.000 26.00797 ?  304 THR   A CG2 1 
ATOM   2344 N N   . PHE   A 1 305 ? 11.38173  28.96305 -36.19182 1.000 34.31501 ?  305 PHE   A N   1 
ATOM   2345 C CA  . PHE   A 1 305 ? 10.84684  27.93753 -37.08954 1.000 38.01405 ?  305 PHE   A CA  1 
ATOM   2346 C C   . PHE   A 1 305 ? 10.60791  28.47144 -38.50290 1.000 39.05436 ?  305 PHE   A C   1 
ATOM   2347 O O   . PHE   A 1 305 ? 10.10636  29.58869 -38.68329 1.000 43.41089 ?  305 PHE   A O   1 
ATOM   2348 C CB  . PHE   A 1 305 ? 9.55341   27.35903 -36.49741 1.000 34.75204 ?  305 PHE   A CB  1 
ATOM   2349 C CG  . PHE   A 1 305 ? 9.67337   26.99072 -35.03247 1.000 35.12747 ?  305 PHE   A CG  1 
ATOM   2350 C CD1 . PHE   A 1 305 ? 10.17940  25.75656 -34.64707 1.000 33.35349 ?  305 PHE   A CD1 1 
ATOM   2351 C CD2 . PHE   A 1 305 ? 9.29232   27.89543 -34.04147 1.000 33.80553 ?  305 PHE   A CD2 1 
ATOM   2352 C CE1 . PHE   A 1 305 ? 10.29261  25.42372 -33.29329 1.000 32.21314 ?  305 PHE   A CE1 1 
ATOM   2353 C CE2 . PHE   A 1 305 ? 9.41070   27.58172 -32.69979 1.000 29.58790 ?  305 PHE   A CE2 1 
ATOM   2354 C CZ  . PHE   A 1 305 ? 9.91036   26.34315 -32.32376 1.000 34.22005 ?  305 PHE   A CZ  1 
HETATM 2355 C C13 . A1ALL B 2 .   ? -19.55919 16.66421 -26.80143 1.000 34.18885 ?  401 A1ALL A C13 1 
HETATM 2356 C C15 . A1ALL B 2 .   ? -19.21822 14.18147 -27.11602 1.000 26.84223 ?  401 A1ALL A C15 1 
HETATM 2357 C C17 . A1ALL B 2 .   ? -20.07880 13.52124 -28.22024 1.000 28.17976 ?  401 A1ALL A C17 1 
HETATM 2358 C C20 . A1ALL B 2 .   ? -19.57284 16.58322 -22.81885 1.000 30.99391 ?  401 A1ALL A C20 1 
HETATM 2359 C C21 . A1ALL B 2 .   ? -19.84897 15.25984 -22.37376 1.000 25.52496 ?  401 A1ALL A C21 1 
HETATM 2360 C C22 . A1ALL B 2 .   ? -20.39644 14.97580 -21.10339 1.000 27.64066 ?  401 A1ALL A C22 1 
HETATM 2361 C C24 . A1ALL B 2 .   ? -21.30754 15.68355 -18.81077 1.000 25.41656 ?  401 A1ALL A C24 1 
HETATM 2362 C C26 . A1ALL B 2 .   ? -21.43662 16.29552 -16.42052 1.000 24.11284 ?  401 A1ALL A C26 1 
HETATM 2363 C C02 . A1ALL B 2 .   ? -16.14303 21.34319 -24.72464 1.000 26.89539 ?  401 A1ALL A C02 1 
HETATM 2364 C C04 . A1ALL B 2 .   ? -18.20548 22.51923 -24.51128 1.000 28.10763 ?  401 A1ALL A C04 1 
HETATM 2365 C C05 . A1ALL B 2 .   ? -18.37359 21.46995 -25.64232 1.000 21.47943 ?  401 A1ALL A C05 1 
HETATM 2366 C C06 . A1ALL B 2 .   ? -17.06547 20.62254 -25.69146 1.000 21.24500 ?  401 A1ALL A C06 1 
HETATM 2367 C C07 . A1ALL B 2 .   ? -16.50042 20.54226 -27.11738 1.000 22.98134 ?  401 A1ALL A C07 1 
HETATM 2368 C C08 . A1ALL B 2 .   ? -17.45822 19.81333 -28.08153 1.000 24.71462 ?  401 A1ALL A C08 1 
HETATM 2369 C C09 . A1ALL B 2 .   ? -16.88786 19.93279 -29.50695 1.000 21.19886 ?  401 A1ALL A C09 1 
HETATM 2370 C C12 . A1ALL B 2 .   ? -19.03828 18.09552 -27.17119 1.000 29.87606 ?  401 A1ALL A C12 1 
HETATM 2371 C C14 . A1ALL B 2 .   ? -18.79398 15.58427 -27.51202 1.000 30.70375 ?  401 A1ALL A C14 1 
HETATM 2372 C C16 . A1ALL B 2 .   ? -17.98689 13.33881 -26.84903 1.000 26.70308 ?  401 A1ALL A C16 1 
HETATM 2373 C C19 . A1ALL B 2 .   ? -19.03257 16.89503 -24.21191 1.000 28.58550 ?  401 A1ALL A C19 1 
HETATM 2374 C C23 . A1ALL B 2 .   ? -20.76007 15.98581 -20.17147 1.000 26.77191 ?  401 A1ALL A C23 1 
HETATM 2375 C C25 . A1ALL B 2 .   ? -20.98023 16.50552 -17.71490 1.000 27.51942 ?  401 A1ALL A C25 1 
HETATM 2376 C C27 . A1ALL B 2 .   ? -22.26713 15.21324 -16.16114 1.000 25.37024 ?  401 A1ALL A C27 1 
HETATM 2377 C C29 . A1ALL B 2 .   ? -22.62645 14.34675 -17.21055 1.000 25.60085 ?  401 A1ALL A C29 1 
HETATM 2378 C C30 . A1ALL B 2 .   ? -22.15739 14.58490 -18.50577 1.000 25.86928 ?  401 A1ALL A C30 1 
HETATM 2379 C C31 . A1ALL B 2 .   ? -20.48719 17.30444 -20.63703 1.000 26.76107 ?  401 A1ALL A C31 1 
HETATM 2380 C C32 . A1ALL B 2 .   ? -19.94644 17.58483 -21.90869 1.000 25.68186 ?  401 A1ALL A C32 1 
HETATM 2381 F F28 . A1ALL B 2 .   ? -22.68893 15.00876 -14.93423 1.000 33.70238 ?  401 A1ALL A F28 1 
HETATM 2382 N N03 . A1ALL B 2 .   ? -16.80097 22.39173 -24.08252 1.000 30.08995 ?  401 A1ALL A N03 1 
HETATM 2383 N N10 . A1ALL B 2 .   ? -17.30385 20.70929 -30.40659 1.000 19.71998 ?  401 A1ALL A N10 1 
HETATM 2384 N N11 . A1ALL B 2 .   ? -17.75756 18.39516 -27.72685 1.000 21.08903 ?  401 A1ALL A N11 1 
HETATM 2385 N N18 . A1ALL B 2 .   ? -19.72628 16.46102 -25.35227 1.000 33.59976 ?  401 A1ALL A N18 1 
HETATM 2386 O O01 . A1ALL B 2 .   ? -14.96686 21.08315 -24.51146 1.000 23.53145 ?  401 A1ALL A O01 1 
HETATM 2387 O O33 . A1ALL B 2 .   ? -18.02727 17.58696 -24.31515 1.000 23.75101 ?  401 A1ALL A O33 1 
HETATM 2388 O O34 . A1ALL B 2 .   ? -19.83506 19.00212 -27.01411 1.000 29.95976 ?  401 A1ALL A O34 1 
HETATM 2389 O O   . HOH   C 3 .   ? 6.47647   19.21775 -26.24476 1.000 30.60433 ?  501 HOH   A O   1 
HETATM 2390 O O   . HOH   C 3 .   ? 6.89317   12.93724 -16.99171 1.000 30.07924 ?  502 HOH   A O   1 
HETATM 2391 O O   . HOH   C 3 .   ? -4.62578  18.08221 -12.71983 1.000 44.94534 ?  503 HOH   A O   1 
HETATM 2392 O O   . HOH   C 3 .   ? -3.62397  13.69661 -45.06166 1.000 28.95740 ?  504 HOH   A O   1 
HETATM 2393 O O   . HOH   C 3 .   ? 3.98082   21.39306 -5.99163  1.000 30.32980 ?  505 HOH   A O   1 
HETATM 2394 O O   . HOH   C 3 .   ? 13.22386  26.56303 3.33619   1.000 39.16616 ?  506 HOH   A O   1 
HETATM 2395 O O   . HOH   C 3 .   ? -8.15686  13.80452 -54.07360 1.000 27.81138 ?  507 HOH   A O   1 
HETATM 2396 O O   . HOH   C 3 .   ? -20.88259 5.34838  -44.92549 1.000 31.34634 ?  508 HOH   A O   1 
HETATM 2397 O O   . HOH   C 3 .   ? 11.95105  19.06755 -40.85011 1.000 32.99667 ?  509 HOH   A O   1 
HETATM 2398 O O   . HOH   C 3 .   ? 5.59315   22.33562 -26.42707 1.000 23.55971 ?  510 HOH   A O   1 
HETATM 2399 O O   . HOH   C 3 .   ? 11.19142  27.96360 1.40346   1.000 39.34515 ?  511 HOH   A O   1 
HETATM 2400 O O   . HOH   C 3 .   ? -12.63661 13.71624 -13.86632 1.000 37.52976 ?  512 HOH   A O   1 
HETATM 2401 O O   . HOH   C 3 .   ? -16.22359 2.77668  -33.10566 1.000 36.60923 ?  513 HOH   A O   1 
HETATM 2402 O O   . HOH   C 3 .   ? 7.31285   23.37133 -15.44361 1.000 18.77504 ?  514 HOH   A O   1 
HETATM 2403 O O   . HOH   C 3 .   ? -17.07626 25.07731 -35.14556 1.000 22.81785 ?  515 HOH   A O   1 
HETATM 2404 O O   . HOH   C 3 .   ? -26.42163 5.96292  -32.13471 1.000 31.33803 ?  516 HOH   A O   1 
HETATM 2405 O O   . HOH   C 3 .   ? 18.98755  7.45518  -18.37915 1.000 30.13711 ?  517 HOH   A O   1 
HETATM 2406 O O   . HOH   C 3 .   ? -5.48327  3.14070  -36.91982 1.000 33.81461 ?  518 HOH   A O   1 
HETATM 2407 O O   . HOH   C 3 .   ? -22.28577 16.30649 -25.43018 1.000 28.84340 ?  519 HOH   A O   1 
HETATM 2408 O O   . HOH   C 3 .   ? 10.22454  28.54516 -30.01380 1.000 36.20175 ?  520 HOH   A O   1 
HETATM 2409 O O   . HOH   C 3 .   ? 14.78766  25.81852 -1.68329  1.000 35.49600 ?  521 HOH   A O   1 
HETATM 2410 O O   . HOH   C 3 .   ? 21.69941  35.98382 -2.86228  1.000 42.19976 ?  522 HOH   A O   1 
HETATM 2411 O O   . HOH   C 3 .   ? 1.56340   17.45922 -6.35021  1.000 30.31609 ?  523 HOH   A O   1 
HETATM 2412 O O   . HOH   C 3 .   ? 14.12299  35.21519 -21.90801 1.000 29.95000 ?  524 HOH   A O   1 
HETATM 2413 O O   . HOH   C 3 .   ? 11.49099  8.32641  -17.35063 1.000 29.43579 ?  525 HOH   A O   1 
HETATM 2414 O O   . HOH   C 3 .   ? 21.07299  23.60211 -4.32924  1.000 33.62162 ?  526 HOH   A O   1 
HETATM 2415 O O   . HOH   C 3 .   ? -2.69032  5.92208  -32.22844 1.000 30.68215 ?  527 HOH   A O   1 
HETATM 2416 O O   . HOH   C 3 .   ? -19.52981 15.27323 -52.75713 1.000 30.97418 ?  528 HOH   A O   1 
HETATM 2417 O O   . HOH   C 3 .   ? 0.35250   25.22442 -19.95607 1.000 23.51233 ?  529 HOH   A O   1 
HETATM 2418 O O   . HOH   C 3 .   ? 7.79833   18.50106 -35.52274 1.000 35.09331 ?  530 HOH   A O   1 
HETATM 2419 O O   . HOH   C 3 .   ? -14.66636 6.70184  -19.96222 1.000 28.58896 ?  531 HOH   A O   1 
HETATM 2420 O O   . HOH   C 3 .   ? -0.30924  26.26716 -43.67776 1.000 25.12224 ?  532 HOH   A O   1 
HETATM 2421 O O   . HOH   C 3 .   ? -5.09466  9.12598  -39.68164 1.000 30.21835 ?  533 HOH   A O   1 
HETATM 2422 O O   . HOH   C 3 .   ? -6.80584  23.94797 -34.67970 1.000 15.77020 ?  534 HOH   A O   1 
HETATM 2423 O O   . HOH   C 3 .   ? -23.17253 20.69718 -51.19419 1.000 35.99381 ?  535 HOH   A O   1 
HETATM 2424 O O   . HOH   C 3 .   ? -11.71812 28.80502 -27.15518 1.000 22.63491 ?  536 HOH   A O   1 
HETATM 2425 O O   . HOH   C 3 .   ? -15.85509 31.25922 -39.86739 1.000 31.50704 ?  537 HOH   A O   1 
HETATM 2426 O O   . HOH   C 3 .   ? -2.83625  7.97406  -15.91170 1.000 32.68991 ?  538 HOH   A O   1 
HETATM 2427 O O   . HOH   C 3 .   ? 27.78040  23.67914 -1.10642  1.000 36.70794 ?  539 HOH   A O   1 
HETATM 2428 O O   . HOH   C 3 .   ? -1.44687  12.03306 -33.78041 1.000 20.07866 ?  540 HOH   A O   1 
HETATM 2429 O O   . HOH   C 3 .   ? -19.15275 23.38432 -43.56391 1.000 20.60659 ?  541 HOH   A O   1 
HETATM 2430 O O   . HOH   C 3 .   ? -19.81174 3.13816  -31.97418 1.000 24.18410 ?  542 HOH   A O   1 
HETATM 2431 O O   . HOH   C 3 .   ? -7.38663  16.50666 -14.76314 1.000 26.14447 ?  543 HOH   A O   1 
HETATM 2432 O O   . HOH   C 3 .   ? -25.88552 16.52757 -44.07291 1.000 33.14281 ?  544 HOH   A O   1 
HETATM 2433 O O   . HOH   C 3 .   ? -19.87628 26.50574 -25.10346 1.000 23.48762 ?  545 HOH   A O   1 
HETATM 2434 O O   . HOH   C 3 .   ? -3.05808  21.12320 -19.52667 1.000 24.54904 ?  546 HOH   A O   1 
HETATM 2435 O O   . HOH   C 3 .   ? -7.54557  12.90294 -23.57876 1.000 16.94752 ?  547 HOH   A O   1 
HETATM 2436 O O   . HOH   C 3 .   ? 0.71430   8.88795  -16.81961 1.000 28.37553 ?  548 HOH   A O   1 
HETATM 2437 O O   . HOH   C 3 .   ? -26.99372 11.29668 -37.82638 1.000 36.25969 ?  549 HOH   A O   1 
HETATM 2438 O O   . HOH   C 3 .   ? 1.68386   33.53291 -21.32007 1.000 23.40823 ?  550 HOH   A O   1 
HETATM 2439 O O   . HOH   C 3 .   ? -15.76834 12.20369 -31.55540 1.000 18.48107 ?  551 HOH   A O   1 
HETATM 2440 O O   . HOH   C 3 .   ? 3.32069   17.00444 -31.01709 1.000 22.61630 ?  552 HOH   A O   1 
HETATM 2441 O O   . HOH   C 3 .   ? -4.20230  22.38818 -54.84731 1.000 31.28677 ?  553 HOH   A O   1 
HETATM 2442 O O   . HOH   C 3 .   ? 4.98752   25.22312 -22.31640 1.000 24.49191 ?  554 HOH   A O   1 
HETATM 2443 O O   . HOH   C 3 .   ? 19.898    9.065    -21.587   1.000 35.38602 ?  555 HOH   A O   1 
HETATM 2444 O O   . HOH   C 3 .   ? 8.27134   16.39865 -19.46347 1.000 20.63565 ?  556 HOH   A O   1 
HETATM 2445 O O   . HOH   C 3 .   ? 8.93120   36.04007 -8.65869  1.000 31.06073 ?  557 HOH   A O   1 
HETATM 2446 O O   . HOH   C 3 .   ? -7.50912  9.28729  -16.47993 1.000 28.17444 ?  558 HOH   A O   1 
HETATM 2447 O O   . HOH   C 3 .   ? -5.67618  26.53156 -48.44277 1.000 29.63223 ?  559 HOH   A O   1 
HETATM 2448 O O   . HOH   C 3 .   ? -9.88838  16.25638 -13.48478 1.000 39.45260 ?  560 HOH   A O   1 
HETATM 2449 O O   . HOH   C 3 .   ? -6.22973  32.34646 -40.07546 1.000 33.83976 ?  561 HOH   A O   1 
HETATM 2450 O O   . HOH   C 3 .   ? -18.51852 20.03243 -49.15556 1.000 28.47367 ?  562 HOH   A O   1 
HETATM 2451 O O   . HOH   C 3 .   ? 1.30169   24.15428 -13.42352 1.000 27.35245 ?  563 HOH   A O   1 
HETATM 2452 O O   . HOH   C 3 .   ? 24.08680  23.16394 -22.21726 1.000 28.63352 ?  564 HOH   A O   1 
HETATM 2453 O O   . HOH   C 3 .   ? 17.52244  17.39797 -23.24637 1.000 25.75952 ?  565 HOH   A O   1 
HETATM 2454 O O   . HOH   C 3 .   ? -17.51276 26.92187 -53.28037 1.000 34.88808 ?  566 HOH   A O   1 
HETATM 2455 O O   . HOH   C 3 .   ? 0.89714   8.49861  -24.52593 1.000 34.48758 ?  567 HOH   A O   1 
HETATM 2456 O O   . HOH   C 3 .   ? 3.31143   24.19513 -5.70607  1.000 32.45007 ?  568 HOH   A O   1 
HETATM 2457 O O   . HOH   C 3 .   ? 18.07570  20.16664 -20.57558 1.000 23.17715 ?  569 HOH   A O   1 
HETATM 2458 O O   . HOH   C 3 .   ? -15.14949 3.72097  -42.27724 1.000 29.88817 ?  570 HOH   A O   1 
HETATM 2459 O O   . HOH   C 3 .   ? -12.10771 5.68573  -26.75229 1.000 31.10562 ?  571 HOH   A O   1 
HETATM 2460 O O   . HOH   C 3 .   ? -21.61573 19.20060 -24.86965 1.000 30.89356 ?  572 HOH   A O   1 
HETATM 2461 O O   . HOH   C 3 .   ? 2.94175   11.01530 -39.65992 1.000 29.31347 ?  573 HOH   A O   1 
HETATM 2462 O O   . HOH   C 3 .   ? 8.29185   20.18336 -25.35224 1.000 31.36912 ?  574 HOH   A O   1 
HETATM 2463 O O   . HOH   C 3 .   ? -14.47072 6.25500  -27.89151 1.000 30.98592 ?  575 HOH   A O   1 
HETATM 2464 O O   . HOH   C 3 .   ? 25.76725  22.71390 -8.72749  1.000 33.50805 ?  576 HOH   A O   1 
HETATM 2465 O O   . HOH   C 3 .   ? 11.77045  18.29682 -22.89384 1.000 24.96949 ?  577 HOH   A O   1 
HETATM 2466 O O   . HOH   C 3 .   ? 3.05663   34.11372 -1.93129  1.000 42.42922 ?  578 HOH   A O   1 
HETATM 2467 O O   . HOH   C 3 .   ? 7.90357   37.52539 -4.04818  1.000 39.88976 ?  579 HOH   A O   1 
HETATM 2468 O O   . HOH   C 3 .   ? 6.03071   27.96830 -23.23053 1.000 24.91907 ?  580 HOH   A O   1 
HETATM 2469 O O   . HOH   C 3 .   ? 8.85419   28.07117 -23.86400 1.000 23.31489 ?  581 HOH   A O   1 
HETATM 2470 O O   . HOH   C 3 .   ? -16.89853 7.28701  -52.01530 1.000 37.88976 ?  582 HOH   A O   1 
HETATM 2471 O O   . HOH   C 3 .   ? 9.02528   13.69442 -13.84147 1.000 22.78131 ?  583 HOH   A O   1 
HETATM 2472 O O   . HOH   C 3 .   ? -0.34311  29.83285 -23.54486 1.000 21.23507 ?  584 HOH   A O   1 
HETATM 2473 O O   . HOH   C 3 .   ? -11.53784 27.70250 -43.07287 1.000 27.85420 ?  585 HOH   A O   1 
HETATM 2474 O O   . HOH   C 3 .   ? -9.91903  3.65255  -41.39235 1.000 38.03105 ?  586 HOH   A O   1 
HETATM 2475 O O   . HOH   C 3 .   ? 14.89863  6.65067  -6.82160  1.000 37.06364 ?  587 HOH   A O   1 
HETATM 2476 O O   . HOH   C 3 .   ? 12.615    32.673   -27.386   1.000 37.85443 ?  588 HOH   A O   1 
HETATM 2477 O O   . HOH   C 3 .   ? -22.88697 11.33434 -52.07618 1.000 33.42847 ?  589 HOH   A O   1 
HETATM 2478 O O   . HOH   C 3 .   ? 15.48807  6.07223  -16.72455 1.000 31.27199 ?  590 HOH   A O   1 
HETATM 2479 O O   . HOH   C 3 .   ? 4.12591   12.20068 -16.82433 1.000 33.94556 ?  591 HOH   A O   1 
HETATM 2480 O O   . HOH   C 3 .   ? 8.79278   15.99547 3.91385   1.000 35.83836 ?  592 HOH   A O   1 
HETATM 2481 O O   . HOH   C 3 .   ? -10.09628 5.77226  -28.49096 1.000 21.14536 ?  593 HOH   A O   1 
HETATM 2482 O O   . HOH   C 3 .   ? -18.31094 6.39929  -27.93856 1.000 30.81734 ?  594 HOH   A O   1 
HETATM 2483 O O   . HOH   C 3 .   ? -14.34532 16.24044 -58.15559 1.000 39.19536 ?  595 HOH   A O   1 
HETATM 2484 O O   . HOH   C 3 .   ? -27.99703 8.28696  -28.10838 1.000 34.97016 ?  596 HOH   A O   1 
HETATM 2485 O O   . HOH   C 3 .   ? -25.12255 15.23070 -37.59330 1.000 34.52914 ?  597 HOH   A O   1 
HETATM 2486 O O   . HOH   C 3 .   ? 3.53590   28.57549 -38.03129 1.000 21.84913 ?  598 HOH   A O   1 
HETATM 2487 O O   . HOH   C 3 .   ? 4.12673   8.85502  -31.97612 1.000 28.60445 ?  599 HOH   A O   1 
HETATM 2488 O O   . HOH   C 3 .   ? 13.31166  24.78351 -34.75798 1.000 42.98172 ?  600 HOH   A O   1 
HETATM 2489 O O   . HOH   C 3 .   ? -5.02624  8.10744  -43.35609 1.000 40.53414 ?  601 HOH   A O   1 
HETATM 2490 O O   . HOH   C 3 .   ? 23.88639  16.99763 -12.97685 1.000 28.83343 ?  602 HOH   A O   1 
HETATM 2491 O O   . HOH   C 3 .   ? 26.74294  21.68409 -4.06163  1.000 35.40994 ?  603 HOH   A O   1 
HETATM 2492 O O   . HOH   C 3 .   ? -2.73742  32.57597 -41.50855 1.000 34.53166 ?  604 HOH   A O   1 
HETATM 2493 O O   . HOH   C 3 .   ? 16.16206  35.65276 -5.96089  1.000 29.91420 ?  605 HOH   A O   1 
HETATM 2494 O O   . HOH   C 3 .   ? 21.37032  10.92887 -10.99294 1.000 35.36234 ?  606 HOH   A O   1 
HETATM 2495 O O   . HOH   C 3 .   ? -5.582    20.190   -55.907   1.000 32.06270 ?  607 HOH   A O   1 
HETATM 2496 O O   . HOH   C 3 .   ? -11.52592 2.15853  -36.91858 1.000 32.40802 ?  608 HOH   A O   1 
HETATM 2497 O O   . HOH   C 3 .   ? -3.91390  6.57248  -23.06921 1.000 25.84300 ?  609 HOH   A O   1 
HETATM 2498 O O   . HOH   C 3 .   ? 23.40540  15.80405 -10.70183 1.000 24.96368 ?  610 HOH   A O   1 
HETATM 2499 O O   . HOH   C 3 .   ? -20.44971 8.04393  -50.58158 1.000 30.23884 ?  611 HOH   A O   1 
HETATM 2500 O O   . HOH   C 3 .   ? -23.23537 22.51638 -34.39457 1.000 35.42649 ?  612 HOH   A O   1 
HETATM 2501 O O   . HOH   C 3 .   ? -13.97519 3.23498  -34.87226 1.000 33.52976 ?  613 HOH   A O   1 
HETATM 2502 O O   . HOH   C 3 .   ? -6.81286  1.39611  -31.67425 1.000 41.87394 ?  614 HOH   A O   1 
HETATM 2503 O O   . HOH   C 3 .   ? -9.94436  4.99440  -24.43118 1.000 36.63246 ?  615 HOH   A O   1 
HETATM 2504 O O   . HOH   C 3 .   ? -16.15802 6.47143  -49.38487 1.000 37.39486 ?  616 HOH   A O   1 
HETATM 2505 O O   . HOH   C 3 .   ? -27.00781 -0.40684 -40.49345 1.000 31.32071 ?  617 HOH   A O   1 
HETATM 2506 O O   . HOH   C 3 .   ? 3.33412   33.29176 -18.44507 1.000 29.28143 ?  618 HOH   A O   1 
HETATM 2507 O O   . HOH   C 3 .   ? -17.43763 13.47465 -19.14726 1.000 41.12480 ?  619 HOH   A O   1 
HETATM 2508 O O   . HOH   C 3 .   ? -0.33986  29.18978 -43.90789 1.000 30.12725 ?  620 HOH   A O   1 
HETATM 2509 O O   . HOH   C 3 .   ? 13.53776  27.24944 0.01448   1.000 32.51935 ?  621 HOH   A O   1 
HETATM 2510 O O   . HOH   C 3 .   ? 6.08013   23.63559 -43.86909 1.000 32.97367 ?  622 HOH   A O   1 
HETATM 2511 O O   . HOH   C 3 .   ? -20.17304 21.49033 -29.35385 1.000 29.95976 ?  623 HOH   A O   1 
HETATM 2512 O O   . HOH   C 3 .   ? 17.23206  36.51334 -1.38762  1.000 41.87976 ?  624 HOH   A O   1 
HETATM 2513 O O   . HOH   C 3 .   ? -20.28948 19.03154 -30.13739 1.000 37.97489 ?  625 HOH   A O   1 
HETATM 2514 O O   . HOH   C 3 .   ? -5.81940  2.17080  -33.56095 1.000 38.10286 ?  626 HOH   A O   1 
HETATM 2515 O O   . HOH   C 3 .   ? 16.69715  28.28831 -34.38280 1.000 33.13755 ?  627 HOH   A O   1 
HETATM 2516 O O   . HOH   C 3 .   ? 17.02660  22.92441 4.73134   1.000 44.82113 ?  628 HOH   A O   1 
HETATM 2517 O O   . HOH   C 3 .   ? 16.46938  28.37962 0.66031   1.000 38.84890 ?  629 HOH   A O   1 
HETATM 2518 O O   . HOH   C 3 .   ? -1.88668  17.94333 -10.43695 1.000 33.09601 ?  630 HOH   A O   1 
HETATM 2519 O O   . HOH   C 3 .   ? 7.535     14.432   -42.168   1.000 32.71389 ?  631 HOH   A O   1 
HETATM 2520 O O   . HOH   C 3 .   ? -4.52085  3.23706  -34.93442 1.000 38.02164 ?  632 HOH   A O   1 
HETATM 2521 O O   . HOH   C 3 .   ? 22.95559  11.41774 -12.29972 1.000 34.26552 ?  633 HOH   A O   1 
HETATM 2522 O O   . HOH   C 3 .   ? -1.05072  6.81679  -24.11739 1.000 36.97860 ?  634 HOH   A O   1 
HETATM 2523 O O   . HOH   C 3 .   ? -16.46145 4.32633  -28.00024 1.000 31.68189 ?  635 HOH   A O   1 
HETATM 2524 O O   . HOH   C 3 .   ? 5.78102   16.38190 -30.91093 1.000 29.97798 ?  636 HOH   A O   1 
HETATM 2525 O O   . HOH   C 3 .   ? 10.47056  16.21970 -21.47699 1.000 31.67142 ?  637 HOH   A O   1 
HETATM 2526 O O   . HOH   C 3 .   ? -12.17872 3.32510  -21.69607 1.000 33.48976 ?  638 HOH   A O   1 
HETATM 2527 O O   . HOH   C 3 .   ? 12.86460  22.89245 -33.47755 1.000 44.94224 ?  639 HOH   A O   1 
HETATM 2528 O O   . HOH   C 3 .   ? 5.29652   24.28934 -2.09202  1.000 36.49479 ?  640 HOH   A O   1 
HETATM 2529 O O   . HOH   C 3 .   ? 19.00115  5.92272  -7.18920  1.000 40.40797 ?  641 HOH   A O   1 
HETATM 2530 O O   . HOH   C 3 .   ? 10.37799  12.81904 -20.06323 1.000 31.00976 ?  642 HOH   A O   1 
HETATM 2531 O O   . HOH   C 3 .   ? -5.943    35.253   -38.003   1.000 28.55219 ?  643 HOH   A O   1 
HETATM 2532 O O   . HOH   C 3 .   ? -13.97546 3.42088  -30.04826 1.000 35.73689 ?  644 HOH   A O   1 
HETATM 2533 O O   . HOH   C 3 .   ? -26.66302 14.15979 -38.99257 1.000 33.84667 ?  645 HOH   A O   1 
HETATM 2534 O O   . HOH   C 3 .   ? -12.23841 3.14585  -31.57272 1.000 35.16728 ?  646 HOH   A O   1 
HETATM 2535 O O   . HOH   C 3 .   ? 9.07965   7.90883  -16.48996 1.000 25.61998 ?  647 HOH   A O   1 
HETATM 2536 O O   . HOH   C 3 .   ? -9.61807  8.69115  -46.60455 1.000 35.61935 ?  648 HOH   A O   1 
HETATM 2537 O O   . HOH   C 3 .   ? 5.90657   21.01714 -47.86611 1.000 41.11573 ?  649 HOH   A O   1 
HETATM 2538 O O   . HOH   C 3 .   ? -4.99679  5.44541  -20.79440 1.000 32.87976 ?  650 HOH   A O   1 
HETATM 2539 O O   . HOH   C 3 .   ? 0.00000   31.98950 -24.97658 0.50  24.82232 ?  651 HOH   A O   1 
HETATM 2540 O O   . HOH   C 3 .   ? 17.24566  20.01302 -23.36982 1.000 35.21545 ?  652 HOH   A O   1 
HETATM 2541 O O   . HOH   C 3 .   ? -24.690   5.376    -18.468   1.000 46.31539 ?  653 HOH   A O   1 
HETATM 2542 O O   . HOH   C 3 .   ? 8.20333   13.93495 -18.80515 1.000 29.06294 ?  654 HOH   A O   1 
HETATM 2543 O O   . HOH   C 3 .   ? -19.55507 3.41821  -43.51785 1.000 31.03253 ?  655 HOH   A O   1 
HETATM 2544 O O   . HOH   C 3 .   ? -28.14079 0.84409  -42.56829 1.000 42.76595 ?  656 HOH   A O   1 
HETATM 2545 O O   . HOH   C 3 .   ? 7.160     14.969   -44.821   1.000 36.83263 ?  657 HOH   A O   1 
HETATM 2546 O O   . HOH   C 3 .   ? -12.54667 3.20664  -26.05196 1.000 30.80857 ?  658 HOH   A O   1 
HETATM 2547 O O   . HOH   C 3 .   ? -7.36277  4.34168  -45.79457 1.000 44.04431 ?  659 HOH   A O   1 
HETATM 2548 O O   . HOH   C 3 .   ? 25.33875  15.16649 -8.79216  1.000 37.96976 ?  660 HOH   A O   1 
HETATM 2549 O O   . HOH   C 3 .   ? 0.00000   31.98950 -19.22749 0.50  20.80380 ?  661 HOH   A O   1 
HETATM 2550 O O   . HOH   C 3 .   ? 19.81453  4.15423  -15.66859 1.000 37.81402 ?  662 HOH   A O   1 
# 
