data_9BBP
# 
_entry.id   9BBP 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BBP         pdb_00009bbp 10.2210/pdb9bbp/pdb 
WWPDB D_1000281853 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-04-16 ? 
2 'Structure model' 1 1 2025-05-14 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' Advisory               
2 2 'Structure model' 'Derived calculations' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' pdbx_struct_assembly         
2 2 'Structure model' pdbx_struct_assembly_gen     
3 2 'Structure model' pdbx_struct_assembly_prop    
4 2 'Structure model' pdbx_struct_oper_list        
5 2 'Structure model' pdbx_unobs_or_zero_occ_atoms 
6 2 'Structure model' pdbx_validate_close_contact  
7 2 'Structure model' struct_conn                  
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_pdbx_struct_assembly.details'             
2 2 'Structure model' '_pdbx_struct_assembly.method_details'      
3 2 'Structure model' '_pdbx_struct_assembly.oligomeric_count'    
4 2 'Structure model' '_pdbx_struct_assembly.oligomeric_details'  
5 2 'Structure model' '_pdbx_struct_assembly_gen.oper_expression' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BBP 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-07 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 4 
_pdbx_contact_author.email              olsens@uthscsa.edu 
_pdbx_contact_author.name_first         Shaun 
_pdbx_contact_author.name_last          Olsen 
_pdbx_contact_author.name_mi            K 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-1265-7101 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Afsar, M.'   1 0000-0002-3062-9219 
'Bury, P.'    2 0000-0003-3445-2649 
'Olsen, S.K.' 3 0000-0002-1265-7101 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'SARS-CoV-2 Mpro in complex with compound 12d inhibitor' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Afsar, M.'   1 0000-0002-3062-9219 
primary 'Bury, P.'    2 0000-0003-3445-2649 
primary 'Olsen, S.K.' 3 0000-0002-1265-7101 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '3C-like proteinase nsp5' 33825.547 1   3.4.22.69 ? ? ? 
2 non-polymer syn GLYCINE 75.067    1   ?         ? ? ? 
3 non-polymer syn VALINE 117.146   1   ?         ? ? ? 
4 non-polymer syn THREONINE 119.119   1   ?         ? ? ? 
5 non-polymer syn PHENYLALANINE 165.189   1   ?         ? ? ? 
6 non-polymer syn 
'N-{(2R)-1-amino-3-[(2R,3S)-2-hydroxypyrrolidin-3-yl]propan-2-yl}-N~2~-[4-(6-fluoropyridin-3-yl)benzoyl]-L-leucinamide' 471.568   
1   ?         ? ? ? 
7 water       nat water 18.015    143 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 GLYCINE                                                                                                                 GLY   
3 VALINE                                                                                                                  VAL   
4 THREONINE                                                                                                               THR   
5 PHENYLALANINE                                                                                                           PHE   
6 'N-{(2R)-1-amino-3-[(2R,3S)-2-hydroxypyrrolidin-3-yl]propan-2-yl}-N~2~-[4-(6-fluoropyridin-3-yl)benzoyl]-L-leucinamide' A1ALW 
7 water                                                                                                                   HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   GLY n 
1 3   PHE n 
1 4   ARG n 
1 5   LYS n 
1 6   MET n 
1 7   ALA n 
1 8   PHE n 
1 9   PRO n 
1 10  SER n 
1 11  GLY n 
1 12  LYS n 
1 13  VAL n 
1 14  GLU n 
1 15  GLY n 
1 16  CYS n 
1 17  MET n 
1 18  VAL n 
1 19  GLN n 
1 20  VAL n 
1 21  THR n 
1 22  CYS n 
1 23  GLY n 
1 24  THR n 
1 25  THR n 
1 26  THR n 
1 27  LEU n 
1 28  ASN n 
1 29  GLY n 
1 30  LEU n 
1 31  TRP n 
1 32  LEU n 
1 33  ASP n 
1 34  ASP n 
1 35  VAL n 
1 36  VAL n 
1 37  TYR n 
1 38  CYS n 
1 39  PRO n 
1 40  ARG n 
1 41  HIS n 
1 42  VAL n 
1 43  ILE n 
1 44  CYS n 
1 45  THR n 
1 46  SER n 
1 47  GLU n 
1 48  ASP n 
1 49  MET n 
1 50  LEU n 
1 51  ASN n 
1 52  PRO n 
1 53  ASN n 
1 54  TYR n 
1 55  GLU n 
1 56  ASP n 
1 57  LEU n 
1 58  LEU n 
1 59  ILE n 
1 60  ARG n 
1 61  LYS n 
1 62  SER n 
1 63  ASN n 
1 64  HIS n 
1 65  ASN n 
1 66  PHE n 
1 67  LEU n 
1 68  VAL n 
1 69  GLN n 
1 70  ALA n 
1 71  GLY n 
1 72  ASN n 
1 73  VAL n 
1 74  GLN n 
1 75  LEU n 
1 76  ARG n 
1 77  VAL n 
1 78  ILE n 
1 79  GLY n 
1 80  HIS n 
1 81  SER n 
1 82  MET n 
1 83  GLN n 
1 84  ASN n 
1 85  CYS n 
1 86  VAL n 
1 87  LEU n 
1 88  LYS n 
1 89  LEU n 
1 90  LYS n 
1 91  VAL n 
1 92  ASP n 
1 93  THR n 
1 94  ALA n 
1 95  ASN n 
1 96  PRO n 
1 97  LYS n 
1 98  THR n 
1 99  PRO n 
1 100 LYS n 
1 101 TYR n 
1 102 LYS n 
1 103 PHE n 
1 104 VAL n 
1 105 ARG n 
1 106 ILE n 
1 107 GLN n 
1 108 PRO n 
1 109 GLY n 
1 110 GLN n 
1 111 THR n 
1 112 PHE n 
1 113 SER n 
1 114 VAL n 
1 115 LEU n 
1 116 ALA n 
1 117 CYS n 
1 118 TYR n 
1 119 ASN n 
1 120 GLY n 
1 121 SER n 
1 122 PRO n 
1 123 SER n 
1 124 GLY n 
1 125 VAL n 
1 126 TYR n 
1 127 GLN n 
1 128 CYS n 
1 129 ALA n 
1 130 MET n 
1 131 ARG n 
1 132 PRO n 
1 133 ASN n 
1 134 PHE n 
1 135 THR n 
1 136 ILE n 
1 137 LYS n 
1 138 GLY n 
1 139 SER n 
1 140 PHE n 
1 141 LEU n 
1 142 ASN n 
1 143 GLY n 
1 144 SER n 
1 145 CYS n 
1 146 GLY n 
1 147 SER n 
1 148 VAL n 
1 149 GLY n 
1 150 PHE n 
1 151 ASN n 
1 152 ILE n 
1 153 ASP n 
1 154 TYR n 
1 155 ASP n 
1 156 CYS n 
1 157 VAL n 
1 158 SER n 
1 159 PHE n 
1 160 CYS n 
1 161 TYR n 
1 162 MET n 
1 163 HIS n 
1 164 HIS n 
1 165 MET n 
1 166 GLU n 
1 167 LEU n 
1 168 PRO n 
1 169 THR n 
1 170 GLY n 
1 171 VAL n 
1 172 HIS n 
1 173 ALA n 
1 174 GLY n 
1 175 THR n 
1 176 ASP n 
1 177 LEU n 
1 178 GLU n 
1 179 GLY n 
1 180 ASN n 
1 181 PHE n 
1 182 TYR n 
1 183 GLY n 
1 184 PRO n 
1 185 PHE n 
1 186 VAL n 
1 187 ASP n 
1 188 ARG n 
1 189 GLN n 
1 190 THR n 
1 191 ALA n 
1 192 GLN n 
1 193 ALA n 
1 194 ALA n 
1 195 GLY n 
1 196 THR n 
1 197 ASP n 
1 198 THR n 
1 199 THR n 
1 200 ILE n 
1 201 THR n 
1 202 VAL n 
1 203 ASN n 
1 204 VAL n 
1 205 LEU n 
1 206 ALA n 
1 207 TRP n 
1 208 LEU n 
1 209 TYR n 
1 210 ALA n 
1 211 ALA n 
1 212 VAL n 
1 213 ILE n 
1 214 ASN n 
1 215 GLY n 
1 216 ASP n 
1 217 ARG n 
1 218 TRP n 
1 219 PHE n 
1 220 LEU n 
1 221 ASN n 
1 222 ARG n 
1 223 PHE n 
1 224 THR n 
1 225 THR n 
1 226 THR n 
1 227 LEU n 
1 228 ASN n 
1 229 ASP n 
1 230 PHE n 
1 231 ASN n 
1 232 LEU n 
1 233 VAL n 
1 234 ALA n 
1 235 MET n 
1 236 LYS n 
1 237 TYR n 
1 238 ASN n 
1 239 TYR n 
1 240 GLU n 
1 241 PRO n 
1 242 LEU n 
1 243 THR n 
1 244 GLN n 
1 245 ASP n 
1 246 HIS n 
1 247 VAL n 
1 248 ASP n 
1 249 ILE n 
1 250 LEU n 
1 251 GLY n 
1 252 PRO n 
1 253 LEU n 
1 254 SER n 
1 255 ALA n 
1 256 GLN n 
1 257 THR n 
1 258 GLY n 
1 259 ILE n 
1 260 ALA n 
1 261 VAL n 
1 262 LEU n 
1 263 ASP n 
1 264 MET n 
1 265 CYS n 
1 266 ALA n 
1 267 SER n 
1 268 LEU n 
1 269 LYS n 
1 270 GLU n 
1 271 LEU n 
1 272 LEU n 
1 273 GLN n 
1 274 ASN n 
1 275 GLY n 
1 276 MET n 
1 277 ASN n 
1 278 GLY n 
1 279 ARG n 
1 280 THR n 
1 281 ILE n 
1 282 LEU n 
1 283 GLY n 
1 284 SER n 
1 285 ALA n 
1 286 LEU n 
1 287 LEU n 
1 288 GLU n 
1 289 ASP n 
1 290 GLU n 
1 291 PHE n 
1 292 THR n 
1 293 PRO n 
1 294 PHE n 
1 295 ASP n 
1 296 VAL n 
1 297 VAL n 
1 298 ARG n 
1 299 GLN n 
1 300 CYS n 
1 301 SER n 
1 302 GLY n 
1 303 VAL n 
1 304 THR n 
1 305 PHE n 
1 306 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   306 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      
;Escherichia coli 'BL21-Gold(DE3)pLysS AG'
;
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     866768 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1ALW non-polymer         . 
'N-{(2R)-1-amino-3-[(2R,3S)-2-hydroxypyrrolidin-3-yl]propan-2-yl}-N~2~-[4-(6-fluoropyridin-3-yl)benzoyl]-L-leucinamide' ? 
'C25 H34 F N5 O3' 471.568 
ALA   'L-peptide linking' y ALANINE ? 'C3 H7 N O2'      89.093  
ARG   'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'  175.209 
ASN   'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'     132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'      133.103 
CYS   'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'    121.158 
GLN   'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'    146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'      147.129 
GLY   'peptide linking'   y GLYCINE ? 'C2 H5 N O2'      75.067  
HIS   'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'  156.162 
HOH   non-polymer         . WATER ? 'H2 O'            18.015  
ILE   'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'     131.173 
LEU   'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'     131.173 
LYS   'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'  147.195 
MET   'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'   149.211 
PHE   'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'     165.189 
PRO   'L-peptide linking' y PROLINE ? 'C5 H9 N O2'      115.130 
SER   'L-peptide linking' y SERINE ? 'C3 H7 N O3'      105.093 
THR   'L-peptide linking' y THREONINE ? 'C4 H9 N O3'      119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'   204.225 
TYR   'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'     181.189 
VAL   'L-peptide linking' y VALINE ? 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1   1   SER SER A . n 
A 1 2   GLY 2   2   2   GLY GLY A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ARG 4   4   4   ARG ARG A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   MET 6   6   6   MET MET A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  CYS 16  16  16  CYS CYS A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  THR 21  21  21  THR THR A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  ASN 28  28  28  ASN ASN A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  TRP 31  31  31  TRP TRP A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  ASP 34  34  34  ASP ASP A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  CYS 38  38  38  CYS CYS A . n 
A 1 39  PRO 39  39  39  PRO PRO A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  CYS 44  44  44  CYS CYS A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  MET 49  49  49  MET MET A . n 
A 1 50  LEU 50  50  50  LEU LEU A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  ASP 56  56  56  ASP ASP A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  HIS 64  64  64  HIS HIS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  MET 82  82  82  MET MET A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  CYS 85  85  85  CYS CYS A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  ASP 92  92  92  ASP ASP A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  PRO 99  99  99  PRO PRO A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ARG 105 105 105 ARG ARG A . n 
A 1 106 ILE 106 106 106 ILE ILE A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 PHE 134 134 134 PHE PHE A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 CYS 145 145 145 CYS CYS A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 ASP 153 153 153 ASP ASP A . n 
A 1 154 TYR 154 154 154 TYR ALA A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 CYS 156 156 156 CYS CYS A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 CYS 160 160 160 CYS CYS A . n 
A 1 161 TYR 161 161 161 TYR TYR A . n 
A 1 162 MET 162 162 162 MET MET A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 MET 165 165 165 MET MET A . n 
A 1 166 GLU 166 166 166 GLU GLU A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 HIS 172 172 172 HIS HIS A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 GLN 189 189 189 GLN GLN A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 GLN 192 192 192 GLN GLN A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 ILE 200 200 200 ILE ILE A . n 
A 1 201 THR 201 201 201 THR THR A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 TRP 207 207 207 TRP TRP A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ARG 217 217 217 ARG ARG A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ASN 221 221 221 ASN ASN A . n 
A 1 222 ARG 222 222 222 ARG ARG A . n 
A 1 223 PHE 223 223 223 PHE PHE A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 MET 235 235 235 MET MET A . n 
A 1 236 LYS 236 236 236 LYS LYS A . n 
A 1 237 TYR 237 237 237 TYR TYR A . n 
A 1 238 ASN 238 238 238 ASN ASN A . n 
A 1 239 TYR 239 239 239 TYR TYR A . n 
A 1 240 GLU 240 240 240 GLU GLU A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 THR 243 243 243 THR THR A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 ASP 248 248 248 ASP ASP A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 THR 257 257 257 THR THR A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 CYS 265 265 265 CYS CYS A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 LYS 269 269 269 LYS LYS A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 ASN 274 274 274 ASN ASN A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 ASN 277 277 277 ASN ASN A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 SER 284 284 284 SER SER A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 PHE 291 291 291 PHE PHE A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 PRO 293 293 293 PRO PRO A . n 
A 1 294 PHE 294 294 294 PHE PHE A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 VAL 296 296 296 VAL VAL A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLN 299 299 299 GLN GLN A . n 
A 1 300 CYS 300 300 300 CYS CYS A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 GLY 302 302 ?   ?   ?   A . n 
A 1 303 VAL 303 303 ?   ?   ?   A . n 
A 1 304 THR 304 304 ?   ?   ?   A . n 
A 1 305 PHE 305 305 ?   ?   ?   A . n 
A 1 306 GLN 306 306 ?   ?   ?   A . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 GLY   ? ? GLY   ? ? 'SUBJECT OF INVESTIGATION' ? 
2 A1ALW ? ? A1ALW ? ? 'SUBJECT OF INVESTIGATION' ? 
3 PHE   ? ? PHE   ? ? 'SUBJECT OF INVESTIGATION' ? 
4 THR   ? ? THR   ? ? 'SUBJECT OF INVESTIGATION' ? 
5 VAL   ? ? VAL   ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 GLY   1   401 302 GLY   GLY A . 
C 3 VAL   1   402 303 VAL   VAL A . 
D 4 THR   1   403 304 THR   THR A . 
E 5 PHE   1   404 305 PHE   PHE A . 
F 6 A1ALW 1   405 401 A1ALW LIG A . 
G 7 HOH   1   501 143 HOH   HOH A . 
G 7 HOH   2   502 96  HOH   HOH A . 
G 7 HOH   3   503 92  HOH   HOH A . 
G 7 HOH   4   504 43  HOH   HOH A . 
G 7 HOH   5   505 115 HOH   HOH A . 
G 7 HOH   6   506 118 HOH   HOH A . 
G 7 HOH   7   507 124 HOH   HOH A . 
G 7 HOH   8   508 139 HOH   HOH A . 
G 7 HOH   9   509 85  HOH   HOH A . 
G 7 HOH   10  510 123 HOH   HOH A . 
G 7 HOH   11  511 5   HOH   HOH A . 
G 7 HOH   12  512 49  HOH   HOH A . 
G 7 HOH   13  513 69  HOH   HOH A . 
G 7 HOH   14  514 172 HOH   HOH A . 
G 7 HOH   15  515 56  HOH   HOH A . 
G 7 HOH   16  516 27  HOH   HOH A . 
G 7 HOH   17  517 55  HOH   HOH A . 
G 7 HOH   18  518 73  HOH   HOH A . 
G 7 HOH   19  519 77  HOH   HOH A . 
G 7 HOH   20  520 22  HOH   HOH A . 
G 7 HOH   21  521 28  HOH   HOH A . 
G 7 HOH   22  522 33  HOH   HOH A . 
G 7 HOH   23  523 99  HOH   HOH A . 
G 7 HOH   24  524 88  HOH   HOH A . 
G 7 HOH   25  525 97  HOH   HOH A . 
G 7 HOH   26  526 136 HOH   HOH A . 
G 7 HOH   27  527 6   HOH   HOH A . 
G 7 HOH   28  528 25  HOH   HOH A . 
G 7 HOH   29  529 18  HOH   HOH A . 
G 7 HOH   30  530 50  HOH   HOH A . 
G 7 HOH   31  531 23  HOH   HOH A . 
G 7 HOH   32  532 140 HOH   HOH A . 
G 7 HOH   33  533 20  HOH   HOH A . 
G 7 HOH   34  534 40  HOH   HOH A . 
G 7 HOH   35  535 67  HOH   HOH A . 
G 7 HOH   36  536 29  HOH   HOH A . 
G 7 HOH   37  537 51  HOH   HOH A . 
G 7 HOH   38  538 26  HOH   HOH A . 
G 7 HOH   39  539 38  HOH   HOH A . 
G 7 HOH   40  540 138 HOH   HOH A . 
G 7 HOH   41  541 16  HOH   HOH A . 
G 7 HOH   42  542 45  HOH   HOH A . 
G 7 HOH   43  543 19  HOH   HOH A . 
G 7 HOH   44  544 57  HOH   HOH A . 
G 7 HOH   45  545 78  HOH   HOH A . 
G 7 HOH   46  546 44  HOH   HOH A . 
G 7 HOH   47  547 111 HOH   HOH A . 
G 7 HOH   48  548 66  HOH   HOH A . 
G 7 HOH   49  549 79  HOH   HOH A . 
G 7 HOH   50  550 2   HOH   HOH A . 
G 7 HOH   51  551 165 HOH   HOH A . 
G 7 HOH   52  552 76  HOH   HOH A . 
G 7 HOH   53  553 114 HOH   HOH A . 
G 7 HOH   54  554 145 HOH   HOH A . 
G 7 HOH   55  555 61  HOH   HOH A . 
G 7 HOH   56  556 167 HOH   HOH A . 
G 7 HOH   57  557 14  HOH   HOH A . 
G 7 HOH   58  558 71  HOH   HOH A . 
G 7 HOH   59  559 60  HOH   HOH A . 
G 7 HOH   60  560 42  HOH   HOH A . 
G 7 HOH   61  561 4   HOH   HOH A . 
G 7 HOH   62  562 48  HOH   HOH A . 
G 7 HOH   63  563 58  HOH   HOH A . 
G 7 HOH   64  564 1   HOH   HOH A . 
G 7 HOH   65  565 17  HOH   HOH A . 
G 7 HOH   66  566 10  HOH   HOH A . 
G 7 HOH   67  567 116 HOH   HOH A . 
G 7 HOH   68  568 173 HOH   HOH A . 
G 7 HOH   69  569 74  HOH   HOH A . 
G 7 HOH   70  570 106 HOH   HOH A . 
G 7 HOH   71  571 62  HOH   HOH A . 
G 7 HOH   72  572 41  HOH   HOH A . 
G 7 HOH   73  573 9   HOH   HOH A . 
G 7 HOH   74  574 30  HOH   HOH A . 
G 7 HOH   75  575 68  HOH   HOH A . 
G 7 HOH   76  576 128 HOH   HOH A . 
G 7 HOH   77  577 8   HOH   HOH A . 
G 7 HOH   78  578 83  HOH   HOH A . 
G 7 HOH   79  579 32  HOH   HOH A . 
G 7 HOH   80  580 46  HOH   HOH A . 
G 7 HOH   81  581 31  HOH   HOH A . 
G 7 HOH   82  582 15  HOH   HOH A . 
G 7 HOH   83  583 13  HOH   HOH A . 
G 7 HOH   84  584 39  HOH   HOH A . 
G 7 HOH   85  585 35  HOH   HOH A . 
G 7 HOH   86  586 135 HOH   HOH A . 
G 7 HOH   87  587 72  HOH   HOH A . 
G 7 HOH   88  588 34  HOH   HOH A . 
G 7 HOH   89  589 12  HOH   HOH A . 
G 7 HOH   90  590 3   HOH   HOH A . 
G 7 HOH   91  591 147 HOH   HOH A . 
G 7 HOH   92  592 37  HOH   HOH A . 
G 7 HOH   93  593 53  HOH   HOH A . 
G 7 HOH   94  594 104 HOH   HOH A . 
G 7 HOH   95  595 52  HOH   HOH A . 
G 7 HOH   96  596 36  HOH   HOH A . 
G 7 HOH   97  597 94  HOH   HOH A . 
G 7 HOH   98  598 65  HOH   HOH A . 
G 7 HOH   99  599 146 HOH   HOH A . 
G 7 HOH   100 600 21  HOH   HOH A . 
G 7 HOH   101 601 80  HOH   HOH A . 
G 7 HOH   102 602 81  HOH   HOH A . 
G 7 HOH   103 603 120 HOH   HOH A . 
G 7 HOH   104 604 119 HOH   HOH A . 
G 7 HOH   105 605 11  HOH   HOH A . 
G 7 HOH   106 606 86  HOH   HOH A . 
G 7 HOH   107 607 141 HOH   HOH A . 
G 7 HOH   108 608 64  HOH   HOH A . 
G 7 HOH   109 609 90  HOH   HOH A . 
G 7 HOH   110 610 24  HOH   HOH A . 
G 7 HOH   111 611 121 HOH   HOH A . 
G 7 HOH   112 612 75  HOH   HOH A . 
G 7 HOH   113 613 70  HOH   HOH A . 
G 7 HOH   114 614 105 HOH   HOH A . 
G 7 HOH   115 615 93  HOH   HOH A . 
G 7 HOH   116 616 63  HOH   HOH A . 
G 7 HOH   117 617 134 HOH   HOH A . 
G 7 HOH   118 618 87  HOH   HOH A . 
G 7 HOH   119 619 164 HOH   HOH A . 
G 7 HOH   120 620 112 HOH   HOH A . 
G 7 HOH   121 621 154 HOH   HOH A . 
G 7 HOH   122 622 7   HOH   HOH A . 
G 7 HOH   123 623 125 HOH   HOH A . 
G 7 HOH   124 624 171 HOH   HOH A . 
G 7 HOH   125 625 109 HOH   HOH A . 
G 7 HOH   126 626 59  HOH   HOH A . 
G 7 HOH   127 627 107 HOH   HOH A . 
G 7 HOH   128 628 129 HOH   HOH A . 
G 7 HOH   129 629 169 HOH   HOH A . 
G 7 HOH   130 630 156 HOH   HOH A . 
G 7 HOH   131 631 127 HOH   HOH A . 
G 7 HOH   132 632 98  HOH   HOH A . 
G 7 HOH   133 633 102 HOH   HOH A . 
G 7 HOH   134 634 84  HOH   HOH A . 
G 7 HOH   135 635 47  HOH   HOH A . 
G 7 HOH   136 636 95  HOH   HOH A . 
G 7 HOH   137 637 170 HOH   HOH A . 
G 7 HOH   138 638 133 HOH   HOH A . 
G 7 HOH   139 639 168 HOH   HOH A . 
G 7 HOH   140 640 151 HOH   HOH A . 
G 7 HOH   141 641 101 HOH   HOH A . 
G 7 HOH   142 642 126 HOH   HOH A . 
G 7 HOH   143 643 122 HOH   HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A TYR 154 ? CG  ? A TYR 154 CG  
2 1 Y 1 A TYR 154 ? CD1 ? A TYR 154 CD1 
3 1 Y 1 A TYR 154 ? CD2 ? A TYR 154 CD2 
4 1 Y 1 A TYR 154 ? CE1 ? A TYR 154 CE1 
5 1 Y 1 A TYR 154 ? CE2 ? A TYR 154 CE2 
6 1 Y 1 A TYR 154 ? CZ  ? A TYR 154 CZ  
7 1 Y 1 A TYR 154 ? OH  ? A TYR 154 OH  
8 1 N 1 A PHE 404 ? OXT ? E PHE 1   OXT 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 1 
? 'model building' ? ? ? ? ? ? ? ? ? ? ? Coot   ? ? ? 0.9.8.7     2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           3 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? SCALA  ? ? ? .           4 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BBP 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     45.642 
_cell.length_a_esd                 ? 
_cell.length_b                     64.190 
_cell.length_b_esd                 ? 
_cell.length_c                     104.816 
_cell.length_c_esd                 ? 
_cell.volume                       307085.722 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BBP 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                18 
_symmetry.space_group_name_Hall            'P 2 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BBP 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.31 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          46.81 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M Sodium Formate, 20% w/v Polyethylene glycol 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-09-23 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.979 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'APS BEAMLINE 24-ID-E' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.979 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   24-ID-E 
_diffrn_source.pdbx_synchrotron_site       APS 
# 
_reflns.B_iso_Wilson_estimate                          25.34 
_reflns.entry_id                                       9BBP 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.79 
_reflns.d_resolution_low                               105.18 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     28406 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           94.6 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                7.8 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          9.6 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.993 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.128 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.79 
_reflns_shell.d_res_low                                     1.89 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.4 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4112 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          95.0 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.467 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               29.04 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9BBP 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.81 
_refine.ls_d_res_low                             41.85 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     27001 
_refine.ls_number_reflns_R_free                  1999 
_refine.ls_number_reflns_R_work                  25002 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    94.04 
_refine.ls_percent_reflns_R_free                 7.40 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2001 
_refine.ls_R_factor_R_free                       0.2366 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1973 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.33 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 25.1911 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2319 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.81 
_refine_hist.d_res_low                        41.85 
_refine_hist.number_atoms_solvent             143 
_refine_hist.number_atoms_total               2528 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2322 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         63 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0091 ? 2438 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.0783 ? 3312 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0653 ? 374  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0081 ? 428  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 8.0024 ? 329  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.81 1.86  . . 96  1206 65.23 . . . . 0.3251 . . . . . . . . . . . 0.3933 
'X-RAY DIFFRACTION' 1.86 1.91  . . 141 1753 93.21 . . . . 0.2756 . . . . . . . . . . . 0.3134 
'X-RAY DIFFRACTION' 1.91 1.96  . . 148 1847 98.96 . . . . 0.2671 . . . . . . . . . . . 0.3184 
'X-RAY DIFFRACTION' 1.96 2.03  . . 146 1835 98.85 . . . . 0.2384 . . . . . . . . . . . 0.2879 
'X-RAY DIFFRACTION' 2.03 2.10  . . 149 1860 98.58 . . . . 0.2363 . . . . . . . . . . . 0.2988 
'X-RAY DIFFRACTION' 2.10 2.18  . . 148 1850 98.38 . . . . 0.2212 . . . . . . . . . . . 0.2727 
'X-RAY DIFFRACTION' 2.18 2.28  . . 148 1847 98.18 . . . . 0.2233 . . . . . . . . . . . 0.2799 
'X-RAY DIFFRACTION' 2.28 2.40  . . 146 1827 98.11 . . . . 0.2181 . . . . . . . . . . . 0.2604 
'X-RAY DIFFRACTION' 2.40 2.55  . . 146 1824 95.96 . . . . 0.2097 . . . . . . . . . . . 0.2600 
'X-RAY DIFFRACTION' 2.56 2.75  . . 139 1733 92.26 . . . . 0.2158 . . . . . . . . . . . 0.2622 
'X-RAY DIFFRACTION' 2.75 3.03  . . 147 1853 96.15 . . . . 0.2151 . . . . . . . . . . . 0.2393 
'X-RAY DIFFRACTION' 3.03 3.47  . . 144 1807 94.89 . . . . 0.1941 . . . . . . . . . . . 0.2050 
'X-RAY DIFFRACTION' 3.47 4.37  . . 147 1833 93.88 . . . . 0.1652 . . . . . . . . . . . 0.2150 
'X-RAY DIFFRACTION' 4.37 41.85 . . 154 1927 93.70 . . . . 0.1464 . . . . . . . . . . . 0.1773 
# 
_struct.entry_id                     9BBP 
_struct.title                        'SARS-CoV-2 Mpro in complex with compound 12d inhibitor' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BBP 
_struct_keywords.text            'Protease, Inhibitor, VIRAL PROTEIN, Hydrolase' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN, Hydrolase' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
F N N 6 ? 
G N N 7 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1A_SARS2 
_struct_ref.pdbx_db_accession          P0DTC1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_struct_ref.pdbx_align_begin           3264 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9BBP 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 306 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P0DTC1 
_struct_ref_seq.db_align_beg                  3264 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3569 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       306 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 4740  ? 
1 MORE         -27   ? 
1 'SSA (A^2)'  25080 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  
0.0000000000 0.0000000000  0.0000000000 0.0000000000 1.0000000000 0.0000000000 
2 'crystal symmetry operation' 2_565 -x,-y+1,z -1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 
0.0000000000 64.1900000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 10  ? GLY A 15  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 41  ? CYS A 44  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 ASN A 53  ? ARG A 60  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P4  AA4 LYS A 61  ? PHE A 66  ? LYS A 61  PHE A 66  5 ? 6  
HELX_P HELX_P5  AA5 ILE A 200 ? ASN A 214 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P6  AA6 THR A 226 ? MET A 235 ? THR A 226 MET A 235 1 ? 10 
HELX_P HELX_P7  AA7 LYS A 236 ? ASN A 238 ? LYS A 236 ASN A 238 5 ? 3  
HELX_P HELX_P8  AA8 THR A 243 ? LEU A 250 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P9  AA9 LEU A 250 ? GLY A 258 ? LEU A 250 GLY A 258 1 ? 9  
HELX_P HELX_P10 AB1 ALA A 260 ? GLY A 275 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P11 AB2 THR A 292 ? SER A 301 ? THR A 292 SER A 301 1 ? 10 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale none ? A CYS 145 SG ? ? ? 1_555 F A1ALW . C09 ? ? A CYS 145 A A1ALW 405 1_555 ? ? ? ? ? ? ? 1.734 ? ? 
covale2 covale both ? B GLY .   C  ? ? ? 1_555 C VAL   . N   ? ? A GLY 401 A VAL   402 1_555 ? ? ? ? ? ? ? 1.336 ? ? 
covale3 covale both ? C VAL .   C  ? ? ? 1_555 D THR   . N   ? ? A VAL 402 A THR   403 1_555 ? ? ? ? ? ? ? 1.333 ? ? 
covale4 covale both ? D THR .   C  ? ? ? 1_555 E PHE   . N   ? ? A THR 403 A PHE   404 1_555 ? ? ? ? ? ? ? 1.334 ? ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      A1ALW 
_pdbx_modification_feature.label_asym_id                      F 
_pdbx_modification_feature.label_seq_id                       . 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      145 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       A1ALW 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        405 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       145 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               C09 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                CYS 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        A1ALW 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Covalent chemical modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 73  ? LEU A 75  ? VAL A 73  LEU A 75  
AA1 2 LEU A 67  ? ALA A 70  ? LEU A 67  ALA A 70  
AA1 3 MET A 17  ? CYS A 22  ? MET A 17  CYS A 22  
AA1 4 THR A 25  ? LEU A 32  ? THR A 25  LEU A 32  
AA1 5 VAL A 35  ? PRO A 39  ? VAL A 35  PRO A 39  
AA1 6 VAL A 86  ? VAL A 91  ? VAL A 86  VAL A 91  
AA1 7 VAL A 77  ? GLN A 83  ? VAL A 77  GLN A 83  
AA2 1 TYR A 101 ? PHE A 103 ? TYR A 101 PHE A 103 
AA2 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA2 3 VAL A 148 ? ASP A 153 ? VAL A 148 ASP A 153 
AA2 4 THR A 111 ? TYR A 118 ? THR A 111 TYR A 118 
AA2 5 SER A 121 ? ALA A 129 ? SER A 121 ALA A 129 
AA3 1 TYR A 101 ? PHE A 103 ? TYR A 101 PHE A 103 
AA3 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA3 3 HIS A 172 ? THR A 175 ? HIS A 172 THR A 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 73  ? O VAL A 73  N ALA A 70  ? N ALA A 70  
AA1 2 3 O LEU A 67  ? O LEU A 67  N THR A 21  ? N THR A 21  
AA1 3 4 N VAL A 18  ? N VAL A 18  O GLY A 29  ? O GLY A 29  
AA1 4 5 N LEU A 30  ? N LEU A 30  O TYR A 37  ? O TYR A 37  
AA1 5 6 N CYS A 38  ? N CYS A 38  O LEU A 87  ? O LEU A 87  
AA1 6 7 O LYS A 88  ? O LYS A 88  N SER A 81  ? N SER A 81  
AA2 1 2 N LYS A 102 ? N LYS A 102 O PHE A 159 ? O PHE A 159 
AA2 2 3 O CYS A 156 ? O CYS A 156 N ASP A 153 ? N ASP A 153 
AA2 3 4 O PHE A 150 ? O PHE A 150 N SER A 113 ? N SER A 113 
AA2 4 5 N ALA A 116 ? N ALA A 116 O SER A 123 ? O SER A 123 
AA3 1 2 N LYS A 102 ? N LYS A 102 O PHE A 159 ? O PHE A 159 
AA3 2 3 N MET A 165 ? N MET A 165 O ALA A 173 ? O ALA A 173 
# 
_pdbx_entry_details.entry_id                   9BBP 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O   A GLY 275 ? ? O A HOH 501 ? ? 2.10 
2 1 O   A HOH 542 ? ? O A HOH 629 ? ? 2.14 
3 1 NH1 A ARG 298 ? ? O A HOH 502 ? ? 2.18 
4 1 O   A HOH 587 ? ? O A HOH 617 ? ? 2.18 
# 
loop_
_pdbx_validate_symm_contact.id 
_pdbx_validate_symm_contact.PDB_model_num 
_pdbx_validate_symm_contact.auth_atom_id_1 
_pdbx_validate_symm_contact.auth_asym_id_1 
_pdbx_validate_symm_contact.auth_comp_id_1 
_pdbx_validate_symm_contact.auth_seq_id_1 
_pdbx_validate_symm_contact.PDB_ins_code_1 
_pdbx_validate_symm_contact.label_alt_id_1 
_pdbx_validate_symm_contact.site_symmetry_1 
_pdbx_validate_symm_contact.auth_atom_id_2 
_pdbx_validate_symm_contact.auth_asym_id_2 
_pdbx_validate_symm_contact.auth_comp_id_2 
_pdbx_validate_symm_contact.auth_seq_id_2 
_pdbx_validate_symm_contact.PDB_ins_code_2 
_pdbx_validate_symm_contact.label_alt_id_2 
_pdbx_validate_symm_contact.site_symmetry_2 
_pdbx_validate_symm_contact.dist 
1 1 O A HOH 639 ? ? 1_555 O A HOH 639 ? ? 2_565 1.76 
2 1 O A HOH 622 ? ? 1_555 O A HOH 622 ? ? 2_565 1.92 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 53.86   -130.84 
2 1 ASN A 51  ? ? -163.39 76.92   
3 1 ASN A 84  ? ? 51.75   -120.11 
4 1 TYR A 154 ? ? 46.65   -92.58  
5 1 PRO A 184 ? ? -93.11  45.36   
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x+1/2,y+1/2,-z 
4 -x,-y,z         
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A GLY 302 ? A GLY 302 
2 1 Y 1 A VAL 303 ? A VAL 303 
3 1 Y 1 A THR 304 ? A THR 304 
4 1 Y 1 A PHE 305 ? A PHE 305 
5 1 Y 1 A GLN 306 ? A GLN 306 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1ALW C13  C N S 1   
A1ALW C15  C N N 2   
A1ALW C17  C N N 3   
A1ALW C20  C Y N 4   
A1ALW C21  C Y N 5   
A1ALW C22  C Y N 6   
A1ALW C24  C Y N 7   
A1ALW C02  C N R 8   
A1ALW C04  C N N 9   
A1ALW C05  C N N 10  
A1ALW C06  C N S 11  
A1ALW C07  C N N 12  
A1ALW C08  C N R 13  
A1ALW C09  C N N 14  
A1ALW C12  C N N 15  
A1ALW C14  C N N 16  
A1ALW C16  C N N 17  
A1ALW C19  C N N 18  
A1ALW C23  C Y N 19  
A1ALW C25  C Y N 20  
A1ALW C27  C Y N 21  
A1ALW C29  C Y N 22  
A1ALW C30  C Y N 23  
A1ALW C31  C Y N 24  
A1ALW C32  C Y N 25  
A1ALW F28  F N N 26  
A1ALW N03  N N N 27  
A1ALW N10  N N N 28  
A1ALW N11  N N N 29  
A1ALW N18  N N N 30  
A1ALW N26  N Y N 31  
A1ALW O01  O N N 32  
A1ALW O33  O N N 33  
A1ALW O34  O N N 34  
A1ALW H131 H N N 35  
A1ALW H151 H N N 36  
A1ALW H173 H N N 37  
A1ALW H172 H N N 38  
A1ALW H171 H N N 39  
A1ALW H211 H N N 40  
A1ALW H221 H N N 41  
A1ALW H021 H N N 42  
A1ALW H041 H N N 43  
A1ALW H042 H N N 44  
A1ALW H052 H N N 45  
A1ALW H051 H N N 46  
A1ALW H061 H N N 47  
A1ALW H071 H N N 48  
A1ALW H072 H N N 49  
A1ALW H081 H N N 50  
A1ALW H092 H N N 51  
A1ALW H091 H N N 52  
A1ALW H141 H N N 53  
A1ALW H142 H N N 54  
A1ALW H162 H N N 55  
A1ALW H163 H N N 56  
A1ALW H161 H N N 57  
A1ALW H251 H N N 58  
A1ALW H291 H N N 59  
A1ALW H301 H N N 60  
A1ALW H311 H N N 61  
A1ALW H321 H N N 62  
A1ALW H1   H N N 63  
A1ALW H102 H N N 64  
A1ALW H2   H N N 65  
A1ALW H111 H N N 66  
A1ALW H181 H N N 67  
A1ALW H011 H N N 68  
ALA   N    N N N 69  
ALA   CA   C N S 70  
ALA   C    C N N 71  
ALA   O    O N N 72  
ALA   CB   C N N 73  
ALA   OXT  O N N 74  
ALA   H    H N N 75  
ALA   H2   H N N 76  
ALA   HA   H N N 77  
ALA   HB1  H N N 78  
ALA   HB2  H N N 79  
ALA   HB3  H N N 80  
ALA   HXT  H N N 81  
ARG   N    N N N 82  
ARG   CA   C N S 83  
ARG   C    C N N 84  
ARG   O    O N N 85  
ARG   CB   C N N 86  
ARG   CG   C N N 87  
ARG   CD   C N N 88  
ARG   NE   N N N 89  
ARG   CZ   C N N 90  
ARG   NH1  N N N 91  
ARG   NH2  N N N 92  
ARG   OXT  O N N 93  
ARG   H    H N N 94  
ARG   H2   H N N 95  
ARG   HA   H N N 96  
ARG   HB2  H N N 97  
ARG   HB3  H N N 98  
ARG   HG2  H N N 99  
ARG   HG3  H N N 100 
ARG   HD2  H N N 101 
ARG   HD3  H N N 102 
ARG   HE   H N N 103 
ARG   HH11 H N N 104 
ARG   HH12 H N N 105 
ARG   HH21 H N N 106 
ARG   HH22 H N N 107 
ARG   HXT  H N N 108 
ASN   N    N N N 109 
ASN   CA   C N S 110 
ASN   C    C N N 111 
ASN   O    O N N 112 
ASN   CB   C N N 113 
ASN   CG   C N N 114 
ASN   OD1  O N N 115 
ASN   ND2  N N N 116 
ASN   OXT  O N N 117 
ASN   H    H N N 118 
ASN   H2   H N N 119 
ASN   HA   H N N 120 
ASN   HB2  H N N 121 
ASN   HB3  H N N 122 
ASN   HD21 H N N 123 
ASN   HD22 H N N 124 
ASN   HXT  H N N 125 
ASP   N    N N N 126 
ASP   CA   C N S 127 
ASP   C    C N N 128 
ASP   O    O N N 129 
ASP   CB   C N N 130 
ASP   CG   C N N 131 
ASP   OD1  O N N 132 
ASP   OD2  O N N 133 
ASP   OXT  O N N 134 
ASP   H    H N N 135 
ASP   H2   H N N 136 
ASP   HA   H N N 137 
ASP   HB2  H N N 138 
ASP   HB3  H N N 139 
ASP   HD2  H N N 140 
ASP   HXT  H N N 141 
CYS   N    N N N 142 
CYS   CA   C N R 143 
CYS   C    C N N 144 
CYS   O    O N N 145 
CYS   CB   C N N 146 
CYS   SG   S N N 147 
CYS   OXT  O N N 148 
CYS   H    H N N 149 
CYS   H2   H N N 150 
CYS   HA   H N N 151 
CYS   HB2  H N N 152 
CYS   HB3  H N N 153 
CYS   HG   H N N 154 
CYS   HXT  H N N 155 
GLN   N    N N N 156 
GLN   CA   C N S 157 
GLN   C    C N N 158 
GLN   O    O N N 159 
GLN   CB   C N N 160 
GLN   CG   C N N 161 
GLN   CD   C N N 162 
GLN   OE1  O N N 163 
GLN   NE2  N N N 164 
GLN   OXT  O N N 165 
GLN   H    H N N 166 
GLN   H2   H N N 167 
GLN   HA   H N N 168 
GLN   HB2  H N N 169 
GLN   HB3  H N N 170 
GLN   HG2  H N N 171 
GLN   HG3  H N N 172 
GLN   HE21 H N N 173 
GLN   HE22 H N N 174 
GLN   HXT  H N N 175 
GLU   N    N N N 176 
GLU   CA   C N S 177 
GLU   C    C N N 178 
GLU   O    O N N 179 
GLU   CB   C N N 180 
GLU   CG   C N N 181 
GLU   CD   C N N 182 
GLU   OE1  O N N 183 
GLU   OE2  O N N 184 
GLU   OXT  O N N 185 
GLU   H    H N N 186 
GLU   H2   H N N 187 
GLU   HA   H N N 188 
GLU   HB2  H N N 189 
GLU   HB3  H N N 190 
GLU   HG2  H N N 191 
GLU   HG3  H N N 192 
GLU   HE2  H N N 193 
GLU   HXT  H N N 194 
GLY   N    N N N 195 
GLY   CA   C N N 196 
GLY   C    C N N 197 
GLY   O    O N N 198 
GLY   OXT  O N N 199 
GLY   H    H N N 200 
GLY   H2   H N N 201 
GLY   HA2  H N N 202 
GLY   HA3  H N N 203 
GLY   HXT  H N N 204 
HIS   N    N N N 205 
HIS   CA   C N S 206 
HIS   C    C N N 207 
HIS   O    O N N 208 
HIS   CB   C N N 209 
HIS   CG   C Y N 210 
HIS   ND1  N Y N 211 
HIS   CD2  C Y N 212 
HIS   CE1  C Y N 213 
HIS   NE2  N Y N 214 
HIS   OXT  O N N 215 
HIS   H    H N N 216 
HIS   H2   H N N 217 
HIS   HA   H N N 218 
HIS   HB2  H N N 219 
HIS   HB3  H N N 220 
HIS   HD1  H N N 221 
HIS   HD2  H N N 222 
HIS   HE1  H N N 223 
HIS   HE2  H N N 224 
HIS   HXT  H N N 225 
HOH   O    O N N 226 
HOH   H1   H N N 227 
HOH   H2   H N N 228 
ILE   N    N N N 229 
ILE   CA   C N S 230 
ILE   C    C N N 231 
ILE   O    O N N 232 
ILE   CB   C N S 233 
ILE   CG1  C N N 234 
ILE   CG2  C N N 235 
ILE   CD1  C N N 236 
ILE   OXT  O N N 237 
ILE   H    H N N 238 
ILE   H2   H N N 239 
ILE   HA   H N N 240 
ILE   HB   H N N 241 
ILE   HG12 H N N 242 
ILE   HG13 H N N 243 
ILE   HG21 H N N 244 
ILE   HG22 H N N 245 
ILE   HG23 H N N 246 
ILE   HD11 H N N 247 
ILE   HD12 H N N 248 
ILE   HD13 H N N 249 
ILE   HXT  H N N 250 
LEU   N    N N N 251 
LEU   CA   C N S 252 
LEU   C    C N N 253 
LEU   O    O N N 254 
LEU   CB   C N N 255 
LEU   CG   C N N 256 
LEU   CD1  C N N 257 
LEU   CD2  C N N 258 
LEU   OXT  O N N 259 
LEU   H    H N N 260 
LEU   H2   H N N 261 
LEU   HA   H N N 262 
LEU   HB2  H N N 263 
LEU   HB3  H N N 264 
LEU   HG   H N N 265 
LEU   HD11 H N N 266 
LEU   HD12 H N N 267 
LEU   HD13 H N N 268 
LEU   HD21 H N N 269 
LEU   HD22 H N N 270 
LEU   HD23 H N N 271 
LEU   HXT  H N N 272 
LYS   N    N N N 273 
LYS   CA   C N S 274 
LYS   C    C N N 275 
LYS   O    O N N 276 
LYS   CB   C N N 277 
LYS   CG   C N N 278 
LYS   CD   C N N 279 
LYS   CE   C N N 280 
LYS   NZ   N N N 281 
LYS   OXT  O N N 282 
LYS   H    H N N 283 
LYS   H2   H N N 284 
LYS   HA   H N N 285 
LYS   HB2  H N N 286 
LYS   HB3  H N N 287 
LYS   HG2  H N N 288 
LYS   HG3  H N N 289 
LYS   HD2  H N N 290 
LYS   HD3  H N N 291 
LYS   HE2  H N N 292 
LYS   HE3  H N N 293 
LYS   HZ1  H N N 294 
LYS   HZ2  H N N 295 
LYS   HZ3  H N N 296 
LYS   HXT  H N N 297 
MET   N    N N N 298 
MET   CA   C N S 299 
MET   C    C N N 300 
MET   O    O N N 301 
MET   CB   C N N 302 
MET   CG   C N N 303 
MET   SD   S N N 304 
MET   CE   C N N 305 
MET   OXT  O N N 306 
MET   H    H N N 307 
MET   H2   H N N 308 
MET   HA   H N N 309 
MET   HB2  H N N 310 
MET   HB3  H N N 311 
MET   HG2  H N N 312 
MET   HG3  H N N 313 
MET   HE1  H N N 314 
MET   HE2  H N N 315 
MET   HE3  H N N 316 
MET   HXT  H N N 317 
PHE   N    N N N 318 
PHE   CA   C N S 319 
PHE   C    C N N 320 
PHE   O    O N N 321 
PHE   CB   C N N 322 
PHE   CG   C Y N 323 
PHE   CD1  C Y N 324 
PHE   CD2  C Y N 325 
PHE   CE1  C Y N 326 
PHE   CE2  C Y N 327 
PHE   CZ   C Y N 328 
PHE   OXT  O N N 329 
PHE   H    H N N 330 
PHE   H2   H N N 331 
PHE   HA   H N N 332 
PHE   HB2  H N N 333 
PHE   HB3  H N N 334 
PHE   HD1  H N N 335 
PHE   HD2  H N N 336 
PHE   HE1  H N N 337 
PHE   HE2  H N N 338 
PHE   HZ   H N N 339 
PHE   HXT  H N N 340 
PRO   N    N N N 341 
PRO   CA   C N S 342 
PRO   C    C N N 343 
PRO   O    O N N 344 
PRO   CB   C N N 345 
PRO   CG   C N N 346 
PRO   CD   C N N 347 
PRO   OXT  O N N 348 
PRO   H    H N N 349 
PRO   HA   H N N 350 
PRO   HB2  H N N 351 
PRO   HB3  H N N 352 
PRO   HG2  H N N 353 
PRO   HG3  H N N 354 
PRO   HD2  H N N 355 
PRO   HD3  H N N 356 
PRO   HXT  H N N 357 
SER   N    N N N 358 
SER   CA   C N S 359 
SER   C    C N N 360 
SER   O    O N N 361 
SER   CB   C N N 362 
SER   OG   O N N 363 
SER   OXT  O N N 364 
SER   H    H N N 365 
SER   H2   H N N 366 
SER   HA   H N N 367 
SER   HB2  H N N 368 
SER   HB3  H N N 369 
SER   HG   H N N 370 
SER   HXT  H N N 371 
THR   N    N N N 372 
THR   CA   C N S 373 
THR   C    C N N 374 
THR   O    O N N 375 
THR   CB   C N R 376 
THR   OG1  O N N 377 
THR   CG2  C N N 378 
THR   OXT  O N N 379 
THR   H    H N N 380 
THR   H2   H N N 381 
THR   HA   H N N 382 
THR   HB   H N N 383 
THR   HG1  H N N 384 
THR   HG21 H N N 385 
THR   HG22 H N N 386 
THR   HG23 H N N 387 
THR   HXT  H N N 388 
TRP   N    N N N 389 
TRP   CA   C N S 390 
TRP   C    C N N 391 
TRP   O    O N N 392 
TRP   CB   C N N 393 
TRP   CG   C Y N 394 
TRP   CD1  C Y N 395 
TRP   CD2  C Y N 396 
TRP   NE1  N Y N 397 
TRP   CE2  C Y N 398 
TRP   CE3  C Y N 399 
TRP   CZ2  C Y N 400 
TRP   CZ3  C Y N 401 
TRP   CH2  C Y N 402 
TRP   OXT  O N N 403 
TRP   H    H N N 404 
TRP   H2   H N N 405 
TRP   HA   H N N 406 
TRP   HB2  H N N 407 
TRP   HB3  H N N 408 
TRP   HD1  H N N 409 
TRP   HE1  H N N 410 
TRP   HE3  H N N 411 
TRP   HZ2  H N N 412 
TRP   HZ3  H N N 413 
TRP   HH2  H N N 414 
TRP   HXT  H N N 415 
TYR   N    N N N 416 
TYR   CA   C N S 417 
TYR   C    C N N 418 
TYR   O    O N N 419 
TYR   CB   C N N 420 
TYR   CG   C Y N 421 
TYR   CD1  C Y N 422 
TYR   CD2  C Y N 423 
TYR   CE1  C Y N 424 
TYR   CE2  C Y N 425 
TYR   CZ   C Y N 426 
TYR   OH   O N N 427 
TYR   OXT  O N N 428 
TYR   H    H N N 429 
TYR   H2   H N N 430 
TYR   HA   H N N 431 
TYR   HB2  H N N 432 
TYR   HB3  H N N 433 
TYR   HD1  H N N 434 
TYR   HD2  H N N 435 
TYR   HE1  H N N 436 
TYR   HE2  H N N 437 
TYR   HH   H N N 438 
TYR   HXT  H N N 439 
VAL   N    N N N 440 
VAL   CA   C N S 441 
VAL   C    C N N 442 
VAL   O    O N N 443 
VAL   CB   C N N 444 
VAL   CG1  C N N 445 
VAL   CG2  C N N 446 
VAL   OXT  O N N 447 
VAL   H    H N N 448 
VAL   H2   H N N 449 
VAL   HA   H N N 450 
VAL   HB   H N N 451 
VAL   HG11 H N N 452 
VAL   HG12 H N N 453 
VAL   HG13 H N N 454 
VAL   HG21 H N N 455 
VAL   HG22 H N N 456 
VAL   HG23 H N N 457 
VAL   HXT  H N N 458 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1ALW C02 C06  sing N N 1   
A1ALW C02 N03  sing N N 2   
A1ALW C02 O01  sing N N 3   
A1ALW C04 C05  sing N N 4   
A1ALW C04 N03  sing N N 5   
A1ALW C05 C06  sing N N 6   
A1ALW C06 C07  sing N N 7   
A1ALW C07 C08  sing N N 8   
A1ALW C08 C09  sing N N 9   
A1ALW C08 N11  sing N N 10  
A1ALW C09 N10  sing N N 11  
A1ALW C12 C13  sing N N 12  
A1ALW C12 N11  sing N N 13  
A1ALW C12 O34  doub N N 14  
A1ALW C13 C14  sing N N 15  
A1ALW C13 N18  sing N N 16  
A1ALW C14 C15  sing N N 17  
A1ALW C15 C16  sing N N 18  
A1ALW C15 C17  sing N N 19  
A1ALW C19 C20  sing N N 20  
A1ALW C19 N18  sing N N 21  
A1ALW C19 O33  doub N N 22  
A1ALW C20 C21  doub Y N 23  
A1ALW C20 C32  sing Y N 24  
A1ALW C21 C22  sing Y N 25  
A1ALW C22 C23  doub Y N 26  
A1ALW C23 C24  sing N N 27  
A1ALW C23 C31  sing Y N 28  
A1ALW C24 C25  doub Y N 29  
A1ALW C24 C30  sing Y N 30  
A1ALW C25 N26  sing Y N 31  
A1ALW C27 C29  sing Y N 32  
A1ALW C27 F28  sing N N 33  
A1ALW C27 N26  doub Y N 34  
A1ALW C29 C30  doub Y N 35  
A1ALW C31 C32  doub Y N 36  
A1ALW C13 H131 sing N N 37  
A1ALW C15 H151 sing N N 38  
A1ALW C17 H173 sing N N 39  
A1ALW C17 H172 sing N N 40  
A1ALW C17 H171 sing N N 41  
A1ALW C21 H211 sing N N 42  
A1ALW C22 H221 sing N N 43  
A1ALW C02 H021 sing N N 44  
A1ALW C04 H041 sing N N 45  
A1ALW C04 H042 sing N N 46  
A1ALW C05 H052 sing N N 47  
A1ALW C05 H051 sing N N 48  
A1ALW C06 H061 sing N N 49  
A1ALW C07 H071 sing N N 50  
A1ALW C07 H072 sing N N 51  
A1ALW C08 H081 sing N N 52  
A1ALW C09 H092 sing N N 53  
A1ALW C09 H091 sing N N 54  
A1ALW C14 H141 sing N N 55  
A1ALW C14 H142 sing N N 56  
A1ALW C16 H162 sing N N 57  
A1ALW C16 H163 sing N N 58  
A1ALW C16 H161 sing N N 59  
A1ALW C25 H251 sing N N 60  
A1ALW C29 H291 sing N N 61  
A1ALW C30 H301 sing N N 62  
A1ALW C31 H311 sing N N 63  
A1ALW C32 H321 sing N N 64  
A1ALW N03 H1   sing N N 65  
A1ALW N10 H102 sing N N 66  
A1ALW N10 H2   sing N N 67  
A1ALW N11 H111 sing N N 68  
A1ALW N18 H181 sing N N 69  
A1ALW O01 H011 sing N N 70  
ALA   N   CA   sing N N 71  
ALA   N   H    sing N N 72  
ALA   N   H2   sing N N 73  
ALA   CA  C    sing N N 74  
ALA   CA  CB   sing N N 75  
ALA   CA  HA   sing N N 76  
ALA   C   O    doub N N 77  
ALA   C   OXT  sing N N 78  
ALA   CB  HB1  sing N N 79  
ALA   CB  HB2  sing N N 80  
ALA   CB  HB3  sing N N 81  
ALA   OXT HXT  sing N N 82  
ARG   N   CA   sing N N 83  
ARG   N   H    sing N N 84  
ARG   N   H2   sing N N 85  
ARG   CA  C    sing N N 86  
ARG   CA  CB   sing N N 87  
ARG   CA  HA   sing N N 88  
ARG   C   O    doub N N 89  
ARG   C   OXT  sing N N 90  
ARG   CB  CG   sing N N 91  
ARG   CB  HB2  sing N N 92  
ARG   CB  HB3  sing N N 93  
ARG   CG  CD   sing N N 94  
ARG   CG  HG2  sing N N 95  
ARG   CG  HG3  sing N N 96  
ARG   CD  NE   sing N N 97  
ARG   CD  HD2  sing N N 98  
ARG   CD  HD3  sing N N 99  
ARG   NE  CZ   sing N N 100 
ARG   NE  HE   sing N N 101 
ARG   CZ  NH1  sing N N 102 
ARG   CZ  NH2  doub N N 103 
ARG   NH1 HH11 sing N N 104 
ARG   NH1 HH12 sing N N 105 
ARG   NH2 HH21 sing N N 106 
ARG   NH2 HH22 sing N N 107 
ARG   OXT HXT  sing N N 108 
ASN   N   CA   sing N N 109 
ASN   N   H    sing N N 110 
ASN   N   H2   sing N N 111 
ASN   CA  C    sing N N 112 
ASN   CA  CB   sing N N 113 
ASN   CA  HA   sing N N 114 
ASN   C   O    doub N N 115 
ASN   C   OXT  sing N N 116 
ASN   CB  CG   sing N N 117 
ASN   CB  HB2  sing N N 118 
ASN   CB  HB3  sing N N 119 
ASN   CG  OD1  doub N N 120 
ASN   CG  ND2  sing N N 121 
ASN   ND2 HD21 sing N N 122 
ASN   ND2 HD22 sing N N 123 
ASN   OXT HXT  sing N N 124 
ASP   N   CA   sing N N 125 
ASP   N   H    sing N N 126 
ASP   N   H2   sing N N 127 
ASP   CA  C    sing N N 128 
ASP   CA  CB   sing N N 129 
ASP   CA  HA   sing N N 130 
ASP   C   O    doub N N 131 
ASP   C   OXT  sing N N 132 
ASP   CB  CG   sing N N 133 
ASP   CB  HB2  sing N N 134 
ASP   CB  HB3  sing N N 135 
ASP   CG  OD1  doub N N 136 
ASP   CG  OD2  sing N N 137 
ASP   OD2 HD2  sing N N 138 
ASP   OXT HXT  sing N N 139 
CYS   N   CA   sing N N 140 
CYS   N   H    sing N N 141 
CYS   N   H2   sing N N 142 
CYS   CA  C    sing N N 143 
CYS   CA  CB   sing N N 144 
CYS   CA  HA   sing N N 145 
CYS   C   O    doub N N 146 
CYS   C   OXT  sing N N 147 
CYS   CB  SG   sing N N 148 
CYS   CB  HB2  sing N N 149 
CYS   CB  HB3  sing N N 150 
CYS   SG  HG   sing N N 151 
CYS   OXT HXT  sing N N 152 
GLN   N   CA   sing N N 153 
GLN   N   H    sing N N 154 
GLN   N   H2   sing N N 155 
GLN   CA  C    sing N N 156 
GLN   CA  CB   sing N N 157 
GLN   CA  HA   sing N N 158 
GLN   C   O    doub N N 159 
GLN   C   OXT  sing N N 160 
GLN   CB  CG   sing N N 161 
GLN   CB  HB2  sing N N 162 
GLN   CB  HB3  sing N N 163 
GLN   CG  CD   sing N N 164 
GLN   CG  HG2  sing N N 165 
GLN   CG  HG3  sing N N 166 
GLN   CD  OE1  doub N N 167 
GLN   CD  NE2  sing N N 168 
GLN   NE2 HE21 sing N N 169 
GLN   NE2 HE22 sing N N 170 
GLN   OXT HXT  sing N N 171 
GLU   N   CA   sing N N 172 
GLU   N   H    sing N N 173 
GLU   N   H2   sing N N 174 
GLU   CA  C    sing N N 175 
GLU   CA  CB   sing N N 176 
GLU   CA  HA   sing N N 177 
GLU   C   O    doub N N 178 
GLU   C   OXT  sing N N 179 
GLU   CB  CG   sing N N 180 
GLU   CB  HB2  sing N N 181 
GLU   CB  HB3  sing N N 182 
GLU   CG  CD   sing N N 183 
GLU   CG  HG2  sing N N 184 
GLU   CG  HG3  sing N N 185 
GLU   CD  OE1  doub N N 186 
GLU   CD  OE2  sing N N 187 
GLU   OE2 HE2  sing N N 188 
GLU   OXT HXT  sing N N 189 
GLY   N   CA   sing N N 190 
GLY   N   H    sing N N 191 
GLY   N   H2   sing N N 192 
GLY   CA  C    sing N N 193 
GLY   CA  HA2  sing N N 194 
GLY   CA  HA3  sing N N 195 
GLY   C   O    doub N N 196 
GLY   C   OXT  sing N N 197 
GLY   OXT HXT  sing N N 198 
HIS   N   CA   sing N N 199 
HIS   N   H    sing N N 200 
HIS   N   H2   sing N N 201 
HIS   CA  C    sing N N 202 
HIS   CA  CB   sing N N 203 
HIS   CA  HA   sing N N 204 
HIS   C   O    doub N N 205 
HIS   C   OXT  sing N N 206 
HIS   CB  CG   sing N N 207 
HIS   CB  HB2  sing N N 208 
HIS   CB  HB3  sing N N 209 
HIS   CG  ND1  sing Y N 210 
HIS   CG  CD2  doub Y N 211 
HIS   ND1 CE1  doub Y N 212 
HIS   ND1 HD1  sing N N 213 
HIS   CD2 NE2  sing Y N 214 
HIS   CD2 HD2  sing N N 215 
HIS   CE1 NE2  sing Y N 216 
HIS   CE1 HE1  sing N N 217 
HIS   NE2 HE2  sing N N 218 
HIS   OXT HXT  sing N N 219 
HOH   O   H1   sing N N 220 
HOH   O   H2   sing N N 221 
ILE   N   CA   sing N N 222 
ILE   N   H    sing N N 223 
ILE   N   H2   sing N N 224 
ILE   CA  C    sing N N 225 
ILE   CA  CB   sing N N 226 
ILE   CA  HA   sing N N 227 
ILE   C   O    doub N N 228 
ILE   C   OXT  sing N N 229 
ILE   CB  CG1  sing N N 230 
ILE   CB  CG2  sing N N 231 
ILE   CB  HB   sing N N 232 
ILE   CG1 CD1  sing N N 233 
ILE   CG1 HG12 sing N N 234 
ILE   CG1 HG13 sing N N 235 
ILE   CG2 HG21 sing N N 236 
ILE   CG2 HG22 sing N N 237 
ILE   CG2 HG23 sing N N 238 
ILE   CD1 HD11 sing N N 239 
ILE   CD1 HD12 sing N N 240 
ILE   CD1 HD13 sing N N 241 
ILE   OXT HXT  sing N N 242 
LEU   N   CA   sing N N 243 
LEU   N   H    sing N N 244 
LEU   N   H2   sing N N 245 
LEU   CA  C    sing N N 246 
LEU   CA  CB   sing N N 247 
LEU   CA  HA   sing N N 248 
LEU   C   O    doub N N 249 
LEU   C   OXT  sing N N 250 
LEU   CB  CG   sing N N 251 
LEU   CB  HB2  sing N N 252 
LEU   CB  HB3  sing N N 253 
LEU   CG  CD1  sing N N 254 
LEU   CG  CD2  sing N N 255 
LEU   CG  HG   sing N N 256 
LEU   CD1 HD11 sing N N 257 
LEU   CD1 HD12 sing N N 258 
LEU   CD1 HD13 sing N N 259 
LEU   CD2 HD21 sing N N 260 
LEU   CD2 HD22 sing N N 261 
LEU   CD2 HD23 sing N N 262 
LEU   OXT HXT  sing N N 263 
LYS   N   CA   sing N N 264 
LYS   N   H    sing N N 265 
LYS   N   H2   sing N N 266 
LYS   CA  C    sing N N 267 
LYS   CA  CB   sing N N 268 
LYS   CA  HA   sing N N 269 
LYS   C   O    doub N N 270 
LYS   C   OXT  sing N N 271 
LYS   CB  CG   sing N N 272 
LYS   CB  HB2  sing N N 273 
LYS   CB  HB3  sing N N 274 
LYS   CG  CD   sing N N 275 
LYS   CG  HG2  sing N N 276 
LYS   CG  HG3  sing N N 277 
LYS   CD  CE   sing N N 278 
LYS   CD  HD2  sing N N 279 
LYS   CD  HD3  sing N N 280 
LYS   CE  NZ   sing N N 281 
LYS   CE  HE2  sing N N 282 
LYS   CE  HE3  sing N N 283 
LYS   NZ  HZ1  sing N N 284 
LYS   NZ  HZ2  sing N N 285 
LYS   NZ  HZ3  sing N N 286 
LYS   OXT HXT  sing N N 287 
MET   N   CA   sing N N 288 
MET   N   H    sing N N 289 
MET   N   H2   sing N N 290 
MET   CA  C    sing N N 291 
MET   CA  CB   sing N N 292 
MET   CA  HA   sing N N 293 
MET   C   O    doub N N 294 
MET   C   OXT  sing N N 295 
MET   CB  CG   sing N N 296 
MET   CB  HB2  sing N N 297 
MET   CB  HB3  sing N N 298 
MET   CG  SD   sing N N 299 
MET   CG  HG2  sing N N 300 
MET   CG  HG3  sing N N 301 
MET   SD  CE   sing N N 302 
MET   CE  HE1  sing N N 303 
MET   CE  HE2  sing N N 304 
MET   CE  HE3  sing N N 305 
MET   OXT HXT  sing N N 306 
PHE   N   CA   sing N N 307 
PHE   N   H    sing N N 308 
PHE   N   H2   sing N N 309 
PHE   CA  C    sing N N 310 
PHE   CA  CB   sing N N 311 
PHE   CA  HA   sing N N 312 
PHE   C   O    doub N N 313 
PHE   C   OXT  sing N N 314 
PHE   CB  CG   sing N N 315 
PHE   CB  HB2  sing N N 316 
PHE   CB  HB3  sing N N 317 
PHE   CG  CD1  doub Y N 318 
PHE   CG  CD2  sing Y N 319 
PHE   CD1 CE1  sing Y N 320 
PHE   CD1 HD1  sing N N 321 
PHE   CD2 CE2  doub Y N 322 
PHE   CD2 HD2  sing N N 323 
PHE   CE1 CZ   doub Y N 324 
PHE   CE1 HE1  sing N N 325 
PHE   CE2 CZ   sing Y N 326 
PHE   CE2 HE2  sing N N 327 
PHE   CZ  HZ   sing N N 328 
PHE   OXT HXT  sing N N 329 
PRO   N   CA   sing N N 330 
PRO   N   CD   sing N N 331 
PRO   N   H    sing N N 332 
PRO   CA  C    sing N N 333 
PRO   CA  CB   sing N N 334 
PRO   CA  HA   sing N N 335 
PRO   C   O    doub N N 336 
PRO   C   OXT  sing N N 337 
PRO   CB  CG   sing N N 338 
PRO   CB  HB2  sing N N 339 
PRO   CB  HB3  sing N N 340 
PRO   CG  CD   sing N N 341 
PRO   CG  HG2  sing N N 342 
PRO   CG  HG3  sing N N 343 
PRO   CD  HD2  sing N N 344 
PRO   CD  HD3  sing N N 345 
PRO   OXT HXT  sing N N 346 
SER   N   CA   sing N N 347 
SER   N   H    sing N N 348 
SER   N   H2   sing N N 349 
SER   CA  C    sing N N 350 
SER   CA  CB   sing N N 351 
SER   CA  HA   sing N N 352 
SER   C   O    doub N N 353 
SER   C   OXT  sing N N 354 
SER   CB  OG   sing N N 355 
SER   CB  HB2  sing N N 356 
SER   CB  HB3  sing N N 357 
SER   OG  HG   sing N N 358 
SER   OXT HXT  sing N N 359 
THR   N   CA   sing N N 360 
THR   N   H    sing N N 361 
THR   N   H2   sing N N 362 
THR   CA  C    sing N N 363 
THR   CA  CB   sing N N 364 
THR   CA  HA   sing N N 365 
THR   C   O    doub N N 366 
THR   C   OXT  sing N N 367 
THR   CB  OG1  sing N N 368 
THR   CB  CG2  sing N N 369 
THR   CB  HB   sing N N 370 
THR   OG1 HG1  sing N N 371 
THR   CG2 HG21 sing N N 372 
THR   CG2 HG22 sing N N 373 
THR   CG2 HG23 sing N N 374 
THR   OXT HXT  sing N N 375 
TRP   N   CA   sing N N 376 
TRP   N   H    sing N N 377 
TRP   N   H2   sing N N 378 
TRP   CA  C    sing N N 379 
TRP   CA  CB   sing N N 380 
TRP   CA  HA   sing N N 381 
TRP   C   O    doub N N 382 
TRP   C   OXT  sing N N 383 
TRP   CB  CG   sing N N 384 
TRP   CB  HB2  sing N N 385 
TRP   CB  HB3  sing N N 386 
TRP   CG  CD1  doub Y N 387 
TRP   CG  CD2  sing Y N 388 
TRP   CD1 NE1  sing Y N 389 
TRP   CD1 HD1  sing N N 390 
TRP   CD2 CE2  doub Y N 391 
TRP   CD2 CE3  sing Y N 392 
TRP   NE1 CE2  sing Y N 393 
TRP   NE1 HE1  sing N N 394 
TRP   CE2 CZ2  sing Y N 395 
TRP   CE3 CZ3  doub Y N 396 
TRP   CE3 HE3  sing N N 397 
TRP   CZ2 CH2  doub Y N 398 
TRP   CZ2 HZ2  sing N N 399 
TRP   CZ3 CH2  sing Y N 400 
TRP   CZ3 HZ3  sing N N 401 
TRP   CH2 HH2  sing N N 402 
TRP   OXT HXT  sing N N 403 
TYR   N   CA   sing N N 404 
TYR   N   H    sing N N 405 
TYR   N   H2   sing N N 406 
TYR   CA  C    sing N N 407 
TYR   CA  CB   sing N N 408 
TYR   CA  HA   sing N N 409 
TYR   C   O    doub N N 410 
TYR   C   OXT  sing N N 411 
TYR   CB  CG   sing N N 412 
TYR   CB  HB2  sing N N 413 
TYR   CB  HB3  sing N N 414 
TYR   CG  CD1  doub Y N 415 
TYR   CG  CD2  sing Y N 416 
TYR   CD1 CE1  sing Y N 417 
TYR   CD1 HD1  sing N N 418 
TYR   CD2 CE2  doub Y N 419 
TYR   CD2 HD2  sing N N 420 
TYR   CE1 CZ   doub Y N 421 
TYR   CE1 HE1  sing N N 422 
TYR   CE2 CZ   sing Y N 423 
TYR   CE2 HE2  sing N N 424 
TYR   CZ  OH   sing N N 425 
TYR   OH  HH   sing N N 426 
TYR   OXT HXT  sing N N 427 
VAL   N   CA   sing N N 428 
VAL   N   H    sing N N 429 
VAL   N   H2   sing N N 430 
VAL   CA  C    sing N N 431 
VAL   CA  CB   sing N N 432 
VAL   CA  HA   sing N N 433 
VAL   C   O    doub N N 434 
VAL   C   OXT  sing N N 435 
VAL   CB  CG1  sing N N 436 
VAL   CB  CG2  sing N N 437 
VAL   CB  HB   sing N N 438 
VAL   CG1 HG11 sing N N 439 
VAL   CG1 HG12 sing N N 440 
VAL   CG1 HG13 sing N N 441 
VAL   CG2 HG21 sing N N 442 
VAL   CG2 HG22 sing N N 443 
VAL   CG2 HG23 sing N N 444 
VAL   OXT HXT  sing N N 445 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' R01GM115568 1 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' R01GM128731 2 
'Cancer Prevention and Research Institute of Texas (CPRIT)'                                'United States' RR200030    3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 2' 
_space_group.name_Hall        'P 2 2ab' 
_space_group.IT_number        18 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9BBP 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.021910 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.015579 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009541 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F ? ? 4.90428 4.07044 ? ? 12.99538 1.63651  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . SER   A 1 1   ? 15.96320  38.05733 -18.84171 1.000 41.36638 ? 1   SER   A N   1 
ATOM   2    C CA  . SER   A 1 1   ? 15.27580  38.62147 -19.99712 1.000 38.51372 ? 1   SER   A CA  1 
ATOM   3    C C   . SER   A 1 1   ? 13.78647  38.24730 -20.06374 1.000 37.56598 ? 1   SER   A C   1 
ATOM   4    O O   . SER   A 1 1   ? 13.11058  38.55841 -21.05356 1.000 27.33856 ? 1   SER   A O   1 
ATOM   5    C CB  . SER   A 1 1   ? 15.97094  38.18813 -21.27356 1.000 33.70735 ? 1   SER   A CB  1 
ATOM   6    O OG  . SER   A 1 1   ? 17.09710  39.01105 -21.55943 1.000 51.11751 ? 1   SER   A OG  1 
ATOM   7    N N   . GLY   A 1 2   ? 13.27166  37.61415 -19.00287 1.000 33.66270 ? 2   GLY   A N   1 
ATOM   8    C CA  . GLY   A 1 2   ? 11.84152  37.39999 -18.87511 1.000 31.02993 ? 2   GLY   A CA  1 
ATOM   9    C C   . GLY   A 1 2   ? 11.42071  36.02495 -19.34044 1.000 25.60516 ? 2   GLY   A C   1 
ATOM   10   O O   . GLY   A 1 2   ? 11.85789  35.55886 -20.39754 1.000 35.72428 ? 2   GLY   A O   1 
ATOM   11   N N   . PHE   A 1 3   ? 10.59756  35.34049 -18.55237 1.000 32.30710 ? 3   PHE   A N   1 
ATOM   12   C CA  . PHE   A 1 3   ? 10.11780  34.01386 -18.91435 1.000 26.27290 ? 3   PHE   A CA  1 
ATOM   13   C C   . PHE   A 1 3   ? 8.60060   34.04636 -18.96022 1.000 24.93958 ? 3   PHE   A C   1 
ATOM   14   O O   . PHE   A 1 3   ? 7.95457   34.49089 -18.00665 1.000 25.77504 ? 3   PHE   A O   1 
ATOM   15   C CB  . PHE   A 1 3   ? 10.61708  32.94909 -17.92838 1.000 23.04229 ? 3   PHE   A CB  1 
ATOM   16   C CG  . PHE   A 1 3   ? 10.41762  31.55460 -18.42030 1.000 22.68970 ? 3   PHE   A CG  1 
ATOM   17   C CD1 . PHE   A 1 3   ? 11.20267  31.05486 -19.44502 1.000 26.40141 ? 3   PHE   A CD1 1 
ATOM   18   C CD2 . PHE   A 1 3   ? 9.43390   30.74739 -17.87102 1.000 24.51029 ? 3   PHE   A CD2 1 
ATOM   19   C CE1 . PHE   A 1 3   ? 11.02554  29.77827 -19.90355 1.000 24.10502 ? 3   PHE   A CE1 1 
ATOM   20   C CE2 . PHE   A 1 3   ? 9.23776   29.46433 -18.32700 1.000 23.76396 ? 3   PHE   A CE2 1 
ATOM   21   C CZ  . PHE   A 1 3   ? 10.02532  28.98555 -19.36283 1.000 23.86921 ? 3   PHE   A CZ  1 
ATOM   22   N N   . ARG   A 1 4   ? 8.02922   33.58397 -20.06854 1.000 26.59272 ? 4   ARG   A N   1 
ATOM   23   C CA  . ARG   A 1 4   ? 6.58677   33.60959 -20.25419 1.000 23.95245 ? 4   ARG   A CA  1 
ATOM   24   C C   . ARG   A 1 4   ? 6.12613   32.25656 -20.77218 1.000 21.88402 ? 4   ARG   A C   1 
ATOM   25   O O   . ARG   A 1 4   ? 6.85989   31.58622 -21.49147 1.000 25.17676 ? 4   ARG   A O   1 
ATOM   26   C CB  . ARG   A 1 4   ? 6.17205   34.72817 -21.24992 1.000 22.62329 ? 4   ARG   A CB  1 
ATOM   27   C CG  . ARG   A 1 4   ? 6.54358   36.15238 -20.80208 1.000 22.33724 ? 4   ARG   A CG  1 
ATOM   28   C CD  . ARG   A 1 4   ? 5.67273   36.53053 -19.64485 1.000 28.24716 ? 4   ARG   A CD  1 
ATOM   29   N NE  . ARG   A 1 4   ? 4.29310   36.15066 -19.93041 1.000 25.42266 ? 4   ARG   A NE  1 
ATOM   30   C CZ  . ARG   A 1 4   ? 3.43676   36.92468 -20.58614 1.000 26.92704 ? 4   ARG   A CZ  1 
ATOM   31   N NH1 . ARG   A 1 4   ? 3.77930   38.13843 -20.97724 1.000 23.00940 ? 4   ARG   A NH1 1 
ATOM   32   N NH2 . ARG   A 1 4   ? 2.21489   36.45959 -20.87373 1.000 22.72084 ? 4   ARG   A NH2 1 
ATOM   33   N N   . LYS   A 1 5   ? 4.89348   31.86893 -20.44480 1.000 21.95837 ? 5   LYS   A N   1 
ATOM   34   C CA  . LYS   A 1 5   ? 4.29782   30.73437 -21.15452 1.000 17.79774 ? 5   LYS   A CA  1 
ATOM   35   C C   . LYS   A 1 5   ? 4.00699   31.15171 -22.59106 1.000 20.20740 ? 5   LYS   A C   1 
ATOM   36   O O   . LYS   A 1 5   ? 3.32949   32.15909 -22.81976 1.000 16.78232 ? 5   LYS   A O   1 
ATOM   37   C CB  . LYS   A 1 5   ? 3.02803   30.26017 -20.44342 1.000 23.74679 ? 5   LYS   A CB  1 
ATOM   38   C CG  . LYS   A 1 5   ? 2.43113   29.02106 -21.07819 1.000 25.61094 ? 5   LYS   A CG  1 
ATOM   39   C CD  . LYS   A 1 5   ? 1.33839   28.42190 -20.21455 1.000 27.89069 ? 5   LYS   A CD  1 
ATOM   40   C CE  . LYS   A 1 5   ? 1.84490   28.08097 -18.82020 1.000 31.79129 ? 5   LYS   A CE  1 
ATOM   41   N NZ  . LYS   A 1 5   ? 0.91533   27.11836 -18.18322 1.000 36.03343 ? 5   LYS   A NZ  1 
ATOM   42   N N   . MET   A 1 6   ? 4.55736   30.42572 -23.56756 1.000 21.88769 ? 6   MET   A N   1 
ATOM   43   C CA  . MET   A 1 6   ? 4.50733   30.90840 -24.93982 1.000 20.79862 ? 6   MET   A CA  1 
ATOM   44   C C   . MET   A 1 6   ? 4.21900   29.78591 -25.92459 1.000 21.05213 ? 6   MET   A C   1 
ATOM   45   O O   . MET   A 1 6   ? 4.71478   28.65966 -25.78845 1.000 20.25261 ? 6   MET   A O   1 
ATOM   46   C CB  . MET   A 1 6   ? 5.79375   31.70549 -25.26681 1.000 24.68740 ? 6   MET   A CB  1 
ATOM   47   C CG  . MET   A 1 6   ? 6.84526   31.05955 -26.11343 1.000 28.70509 ? 6   MET   A CG  1 
ATOM   48   S SD  . MET   A 1 6   ? 8.12144   32.26895 -26.62522 1.000 36.08782 ? 6   MET   A SD  1 
ATOM   49   C CE  . MET   A 1 6   ? 8.59493   33.08480 -25.13266 1.000 29.16525 ? 6   MET   A CE  1 
ATOM   50   N N   . ALA   A 1 7   ? 3.33925   30.09707 -26.86110 1.000 15.30942 ? 7   ALA   A N   1 
ATOM   51   C CA  . ALA   A 1 7   ? 2.83357   29.14619 -27.84084 1.000 15.52398 ? 7   ALA   A CA  1 
ATOM   52   C C   . ALA   A 1 7   ? 3.66060   29.22718 -29.10498 1.000 18.84276 ? 7   ALA   A C   1 
ATOM   53   O O   . ALA   A 1 7   ? 4.28220   30.25287 -29.39234 1.000 21.33939 ? 7   ALA   A O   1 
ATOM   54   C CB  . ALA   A 1 7   ? 1.36477   29.43518 -28.17352 1.000 19.32743 ? 7   ALA   A CB  1 
ATOM   55   N N   . PHE   A 1 8   ? 3.62487   28.15015 -29.88694 1.000 20.31103 ? 8   PHE   A N   1 
ATOM   56   C CA  . PHE   A 1 8   ? 4.24287   28.17092 -31.20598 1.000 21.10177 ? 8   PHE   A CA  1 
ATOM   57   C C   . PHE   A 1 8   ? 3.50995   29.14962 -32.12341 1.000 20.79497 ? 8   PHE   A C   1 
ATOM   58   O O   . PHE   A 1 8   ? 2.29432   29.33783 -31.99795 1.000 20.58933 ? 8   PHE   A O   1 
ATOM   59   C CB  . PHE   A 1 8   ? 4.23220   26.77574 -31.83850 1.000 19.36032 ? 8   PHE   A CB  1 
ATOM   60   C CG  . PHE   A 1 8   ? 5.24192   25.82230 -31.23241 1.000 19.76457 ? 8   PHE   A CG  1 
ATOM   61   C CD1 . PHE   A 1 8   ? 6.58803   25.91054 -31.55955 1.000 22.39452 ? 8   PHE   A CD1 1 
ATOM   62   C CD2 . PHE   A 1 8   ? 4.84034   24.83702 -30.33554 1.000 21.64654 ? 8   PHE   A CD2 1 
ATOM   63   C CE1 . PHE   A 1 8   ? 7.50076   25.04675 -30.99168 1.000 25.93342 ? 8   PHE   A CE1 1 
ATOM   64   C CE2 . PHE   A 1 8   ? 5.74704   23.97413 -29.77028 1.000 22.32895 ? 8   PHE   A CE2 1 
ATOM   65   C CZ  . PHE   A 1 8   ? 7.07391   24.06103 -30.10635 1.000 25.64154 ? 8   PHE   A CZ  1 
ATOM   66   N N   . PRO   A 1 9   ? 4.22101   29.76841 -33.06846 1.000 22.68955 ? 9   PRO   A N   1 
ATOM   67   C CA  . PRO   A 1 9   ? 3.53909   30.54156 -34.12111 1.000 18.85291 ? 9   PRO   A CA  1 
ATOM   68   C C   . PRO   A 1 9   ? 2.52974   29.64863 -34.84127 1.000 19.47348 ? 9   PRO   A C   1 
ATOM   69   O O   . PRO   A 1 9   ? 2.85278   28.52318 -35.22842 1.000 23.23832 ? 9   PRO   A O   1 
ATOM   70   C CB  . PRO   A 1 9   ? 4.68089   30.95012 -35.06587 1.000 22.30371 ? 9   PRO   A CB  1 
ATOM   71   C CG  . PRO   A 1 9   ? 5.97520   30.60673 -34.33285 1.000 26.36025 ? 9   PRO   A CG  1 
ATOM   72   C CD  . PRO   A 1 9   ? 5.65110   29.53194 -33.36436 1.000 22.23328 ? 9   PRO   A CD  1 
ATOM   73   N N   . SER   A 1 10  ? 1.29883   30.14101 -35.01423 1.000 18.99430 ? 10  SER   A N   1 
ATOM   74   C CA  . SER   A 1 10  ? 0.19901   29.26712 -35.45586 1.000 21.48035 ? 10  SER   A CA  1 
ATOM   75   C C   . SER   A 1 10  ? -0.09397  29.30064 -36.95707 1.000 20.66234 ? 10  SER   A C   1 
ATOM   76   O O   . SER   A 1 10  ? -0.99653  28.58017 -37.41915 1.000 21.50102 ? 10  SER   A O   1 
ATOM   77   C CB  . SER   A 1 10  ? -1.08039  29.60507 -34.69529 1.000 20.73007 ? 10  SER   A CB  1 
ATOM   78   O OG  . SER   A 1 10  ? -1.45038  30.94430 -34.90087 1.000 23.98469 ? 10  SER   A OG  1 
ATOM   79   N N   . GLY   A 1 11  ? 0.64409   30.08653 -37.73247 1.000 23.71781 ? 11  GLY   A N   1 
ATOM   80   C CA  . GLY   A 1 11  ? 0.22998   30.34532 -39.10886 1.000 19.70045 ? 11  GLY   A CA  1 
ATOM   81   C C   . GLY   A 1 11  ? 0.17636   29.09763 -39.97805 1.000 22.90293 ? 11  GLY   A C   1 
ATOM   82   O O   . GLY   A 1 11  ? -0.74367  28.93938 -40.78409 1.000 21.39011 ? 11  GLY   A O   1 
ATOM   83   N N   . LYS   A 1 12  ? 1.16709   28.20438 -39.83412 1.000 22.85284 ? 12  LYS   A N   1 
ATOM   84   C CA  . LYS   A 1 12  ? 1.15842   26.94376 -40.57721 1.000 24.93031 ? 12  LYS   A CA  1 
ATOM   85   C C   . LYS   A 1 12  ? -0.11195  26.13348 -40.30709 1.000 26.60953 ? 12  LYS   A C   1 
ATOM   86   O O   . LYS   A 1 12  ? -0.67613  25.52308 -41.22436 1.000 27.19428 ? 12  LYS   A O   1 
ATOM   87   C CB  . LYS   A 1 12  ? 2.40569   26.12379 -40.22957 1.000 23.22259 ? 12  LYS   A CB  1 
ATOM   88   C CG  . LYS   A 1 12  ? 3.72060   26.71909 -40.70668 1.000 33.47522 ? 12  LYS   A CG  1 
ATOM   89   C CD  . LYS   A 1 12  ? 4.88156   25.78177 -40.35240 1.000 34.48186 ? 12  LYS   A CD  1 
ATOM   90   C CE  . LYS   A 1 12  ? 6.18823   26.27877 -40.93181 1.000 40.46773 ? 12  LYS   A CE  1 
ATOM   91   N NZ  . LYS   A 1 12  ? 5.99667   26.57386 -42.36950 1.000 44.86477 ? 12  LYS   A NZ  1 
ATOM   92   N N   . VAL   A 1 13  ? -0.58160  26.11124 -39.05678 1.000 20.45725 ? 13  VAL   A N   1 
ATOM   93   C CA  . VAL   A 1 13  ? -1.79642  25.36250 -38.74446 1.000 19.90661 ? 13  VAL   A CA  1 
ATOM   94   C C   . VAL   A 1 13  ? -3.06291  26.12614 -39.15890 1.000 19.97637 ? 13  VAL   A C   1 
ATOM   95   O O   . VAL   A 1 13  ? -4.03721  25.50855 -39.59530 1.000 22.22784 ? 13  VAL   A O   1 
ATOM   96   C CB  . VAL   A 1 13  ? -1.80472  25.00305 -37.25250 1.000 19.69074 ? 13  VAL   A CB  1 
ATOM   97   C CG1 . VAL   A 1 13  ? -3.09034  24.29188 -36.87435 1.000 22.64973 ? 13  VAL   A CG1 1 
ATOM   98   C CG2 . VAL   A 1 13  ? -0.57459  24.15690 -36.91957 1.000 22.01772 ? 13  VAL   A CG2 1 
ATOM   99   N N   . GLU   A 1 14  ? -3.07155  27.45872 -39.04492 1.000 21.46925 ? 14  GLU   A N   1 
ATOM   100  C CA  . GLU   A 1 14  ? -4.21495  28.25421 -39.51022 1.000 18.73283 ? 14  GLU   A CA  1 
ATOM   101  C C   . GLU   A 1 14  ? -4.56576  27.93770 -40.96353 1.000 24.26649 ? 14  GLU   A C   1 
ATOM   102  O O   . GLU   A 1 14  ? -5.75175  27.89470 -41.34191 1.000 24.35618 ? 14  GLU   A O   1 
ATOM   103  C CB  . GLU   A 1 14  ? -3.89954  29.74241 -39.38640 1.000 24.26844 ? 14  GLU   A CB  1 
ATOM   104  C CG  . GLU   A 1 14  ? -3.69997  30.23658 -37.97477 1.000 21.53851 ? 14  GLU   A CG  1 
ATOM   105  C CD  . GLU   A 1 14  ? -3.25881  31.70308 -37.93171 1.000 23.79820 ? 14  GLU   A CD  1 
ATOM   106  O OE1 . GLU   A 1 14  ? -3.85737  32.53890 -38.64913 1.000 25.38158 ? 14  GLU   A OE1 1 
ATOM   107  O OE2 . GLU   A 1 14  ? -2.32202  32.01423 -37.16723 1.000 25.55242 ? 14  GLU   A OE2 1 
ATOM   108  N N   . GLY   A 1 15  ? -3.54151  27.73265 -41.79762 1.000 24.03522 ? 15  GLY   A N   1 
ATOM   109  C CA  . GLY   A 1 15  ? -3.74799  27.43434 -43.20823 1.000 26.29681 ? 15  GLY   A CA  1 
ATOM   110  C C   . GLY   A 1 15  ? -4.41288  26.10735 -43.48707 1.000 27.53641 ? 15  GLY   A C   1 
ATOM   111  O O   . GLY   A 1 15  ? -4.75489  25.85324 -44.64957 1.000 28.97929 ? 15  GLY   A O   1 
ATOM   112  N N   . CYS   A 1 16  ? -4.59725  25.25342 -42.46584 1.000 23.36500 ? 16  CYS   A N   1 
ATOM   113  C CA  . CYS   A 1 16  ? -5.20602  23.93861 -42.64156 1.000 22.89468 ? 16  CYS   A CA  1 
ATOM   114  C C   . CYS   A 1 16  ? -6.58518  23.82304 -42.01780 1.000 24.54778 ? 16  CYS   A C   1 
ATOM   115  O O   . CYS   A 1 16  ? -7.21950  22.78184 -42.15130 1.000 25.81030 ? 16  CYS   A O   1 
ATOM   116  C CB  . CYS   A 1 16  ? -4.33154  22.83758 -42.03550 1.000 23.45165 ? 16  CYS   A CB  1 
ATOM   117  S SG  . CYS   A 1 16  ? -2.59371  22.84233 -42.50892 1.000 26.10154 ? 16  CYS   A SG  1 
ATOM   118  N N   . MET   A 1 17  ? -7.05323  24.83646 -41.31294 1.000 21.47105 ? 17  MET   A N   1 
ATOM   119  C CA  . MET   A 1 17  ? -8.33007  24.75248 -40.62413 1.000 19.89317 ? 17  MET   A CA  1 
ATOM   120  C C   . MET   A 1 17  ? -9.48679  24.92275 -41.60185 1.000 17.69006 ? 17  MET   A C   1 
ATOM   121  O O   . MET   A 1 17  ? -9.46345  25.83251 -42.43041 1.000 22.31254 ? 17  MET   A O   1 
ATOM   122  C CB  . MET   A 1 17  ? -8.36347  25.83234 -39.54164 1.000 18.55292 ? 17  MET   A CB  1 
ATOM   123  C CG  . MET   A 1 17  ? -7.62245  25.53609 -38.26510 1.000 21.63815 ? 17  MET   A CG  1 
ATOM   124  S SD  . MET   A 1 17  ? -7.24103  23.81964 -37.81708 1.000 23.23636 ? 17  MET   A SD  1 
ATOM   125  C CE  . MET   A 1 17  ? -8.79845  23.31921 -37.11243 1.000 24.40509 ? 17  MET   A CE  1 
ATOM   126  N N   . VAL   A 1 18  ? -10.50232 24.05624 -41.49049 1.000 22.62529 ? 18  VAL   A N   1 
ATOM   127  C CA  . VAL   A 1 18  ? -11.71429 24.13312 -42.30147 1.000 22.98042 ? 18  VAL   A CA  1 
ATOM   128  C C   . VAL   A 1 18  ? -12.92415 23.85111 -41.41269 1.000 21.61363 ? 18  VAL   A C   1 
ATOM   129  O O   . VAL   A 1 18  ? -12.80896 23.31494 -40.31235 1.000 19.79448 ? 18  VAL   A O   1 
ATOM   130  C CB  . VAL   A 1 18  ? -11.70438 23.13758 -43.49751 1.000 20.39259 ? 18  VAL   A CB  1 
ATOM   131  C CG1 . VAL   A 1 18  ? -10.51178 23.40962 -44.40854 1.000 24.19058 ? 18  VAL   A CG1 1 
ATOM   132  C CG2 . VAL   A 1 18  ? -11.68944 21.70025 -43.02724 1.000 21.58848 ? 18  VAL   A CG2 1 
ATOM   133  N N   . GLN   A 1 19  ? -14.09306 24.21006 -41.91807 1.000 18.83328 ? 19  GLN   A N   1 
ATOM   134  C CA  . GLN   A 1 19  ? -15.35265 23.96165 -41.24690 1.000 23.93293 ? 19  GLN   A CA  1 
ATOM   135  C C   . GLN   A 1 19  ? -15.99151 22.70393 -41.83285 1.000 27.88842 ? 19  GLN   A C   1 
ATOM   136  O O   . GLN   A 1 19  ? -15.92552 22.47871 -43.04738 1.000 29.17697 ? 19  GLN   A O   1 
ATOM   137  C CB  . GLN   A 1 19  ? -16.23416 25.19980 -41.43382 1.000 28.37973 ? 19  GLN   A CB  1 
ATOM   138  C CG  . GLN   A 1 19  ? -17.65326 25.09828 -41.04412 1.000 32.49383 ? 19  GLN   A CG  1 
ATOM   139  C CD  . GLN   A 1 19  ? -18.33143 26.45416 -41.11627 1.000 34.82768 ? 19  GLN   A CD  1 
ATOM   140  O OE1 . GLN   A 1 19  ? -19.03840 26.84422 -40.19315 1.000 41.10331 ? 19  GLN   A OE1 1 
ATOM   141  N NE2 . GLN   A 1 19  ? -18.07262 27.20240 -42.19802 1.000 36.83810 ? 19  GLN   A NE2 1 
ATOM   142  N N   . VAL   A 1 20  ? -16.56593 21.85954 -40.97401 1.000 24.04518 ? 20  VAL   A N   1 
ATOM   143  C CA  . VAL   A 1 20  ? -17.19301 20.60692 -41.40847 1.000 24.25139 ? 20  VAL   A CA  1 
ATOM   144  C C   . VAL   A 1 20  ? -18.60515 20.55699 -40.84837 1.000 29.82524 ? 20  VAL   A C   1 
ATOM   145  O O   . VAL   A 1 20  ? -18.78547 20.54466 -39.62551 1.000 23.74438 ? 20  VAL   A O   1 
ATOM   146  C CB  . VAL   A 1 20  ? -16.41747 19.35396 -40.96050 1.000 26.64304 ? 20  VAL   A CB  1 
ATOM   147  C CG1 . VAL   A 1 20  ? -17.16696 18.08028 -41.42327 1.000 26.52479 ? 20  VAL   A CG1 1 
ATOM   148  C CG2 . VAL   A 1 20  ? -14.98167 19.35623 -41.52216 1.000 25.77207 ? 20  VAL   A CG2 1 
ATOM   149  N N   . THR   A 1 21  ? -19.60251 20.46929 -41.73060 1.000 27.21143 ? 21  THR   A N   1 
ATOM   150  C CA  . THR   A 1 21  ? -20.99825 20.45709 -41.30611 1.000 30.61369 ? 21  THR   A CA  1 
ATOM   151  C C   . THR   A 1 21  ? -21.66554 19.18900 -41.81148 1.000 31.17267 ? 21  THR   A C   1 
ATOM   152  O O   . THR   A 1 21  ? -21.55602 18.85647 -42.99729 1.000 28.36599 ? 21  THR   A O   1 
ATOM   153  C CB  . THR   A 1 21  ? -21.74343 21.68894 -41.82453 1.000 32.18241 ? 21  THR   A CB  1 
ATOM   154  O OG1 . THR   A 1 21  ? -21.16115 22.85794 -41.24018 1.000 28.64413 ? 21  THR   A OG1 1 
ATOM   155  C CG2 . THR   A 1 21  ? -23.19946 21.62457 -41.39105 1.000 33.23307 ? 21  THR   A CG2 1 
ATOM   156  N N   . CYS   A 1 22  ? -22.35012 18.48589 -40.91378 1.000 27.64294 ? 22  CYS   A N   1 
ATOM   157  C CA  . CYS   A 1 22  ? -23.10000 17.28369 -41.27368 1.000 32.22258 ? 22  CYS   A CA  1 
ATOM   158  C C   . CYS   A 1 22  ? -24.45287 17.38193 -40.58655 1.000 39.03572 ? 22  CYS   A C   1 
ATOM   159  O O   . CYS   A 1 22  ? -24.53375 17.21480 -39.36501 1.000 37.66145 ? 22  CYS   A O   1 
ATOM   160  C CB  . CYS   A 1 22  ? -22.35025 16.01932 -40.85263 1.000 29.60200 ? 22  CYS   A CB  1 
ATOM   161  S SG  . CYS   A 1 22  ? -23.13778 14.50623 -41.34633 1.000 43.42277 ? 22  CYS   A SG  1 
ATOM   162  N N   . GLY   A 1 23  ? -25.50134 17.68508 -41.36103 1.000 35.82734 ? 23  GLY   A N   1 
ATOM   163  C CA  . GLY   A 1 23  ? -26.82430 17.92266 -40.80784 1.000 38.48863 ? 23  GLY   A CA  1 
ATOM   164  C C   . GLY   A 1 23  ? -26.92994 19.32487 -40.25210 1.000 35.28827 ? 23  GLY   A C   1 
ATOM   165  O O   . GLY   A 1 23  ? -26.82237 20.29434 -41.00117 1.000 45.21146 ? 23  GLY   A O   1 
ATOM   166  N N   . THR   A 1 24  ? -27.10575 19.45254 -38.93964 1.000 39.52160 ? 24  THR   A N   1 
ATOM   167  C CA  . THR   A 1 24  ? -27.04126 20.74293 -38.26287 1.000 41.91996 ? 24  THR   A CA  1 
ATOM   168  C C   . THR   A 1 24  ? -25.83788 20.86601 -37.33385 1.000 39.03465 ? 24  THR   A C   1 
ATOM   169  O O   . THR   A 1 24  ? -25.63088 21.93176 -36.74208 1.000 42.72334 ? 24  THR   A O   1 
ATOM   170  C CB  . THR   A 1 24  ? -28.34312 21.00430 -37.48549 1.000 48.48830 ? 24  THR   A CB  1 
ATOM   171  O OG1 . THR   A 1 24  ? -28.40313 20.16370 -36.32435 1.000 46.13585 ? 24  THR   A OG1 1 
ATOM   172  C CG2 . THR   A 1 24  ? -29.56209 20.76039 -38.36928 1.000 48.25164 ? 24  THR   A CG2 1 
ATOM   173  N N   . THR   A 1 25  ? -25.03483 19.81488 -37.20508 1.000 37.24412 ? 25  THR   A N   1 
ATOM   174  C CA  . THR   A 1 25  ? -23.81479 19.86231 -36.40959 1.000 38.97255 ? 25  THR   A CA  1 
ATOM   175  C C   . THR   A 1 25  ? -22.65566 20.38540 -37.24837 1.000 33.32208 ? 25  THR   A C   1 
ATOM   176  O O   . THR   A 1 25  ? -22.38477 19.85894 -38.33733 1.000 29.23258 ? 25  THR   A O   1 
ATOM   177  C CB  . THR   A 1 25  ? -23.46541 18.47603 -35.86472 1.000 38.69877 ? 25  THR   A CB  1 
ATOM   178  O OG1 . THR   A 1 25  ? -24.57714 17.93939 -35.13951 1.000 46.05249 ? 25  THR   A OG1 1 
ATOM   179  C CG2 . THR   A 1 25  ? -22.24491 18.54923 -34.96622 1.000 37.45991 ? 25  THR   A CG2 1 
ATOM   180  N N   . THR   A 1 26  ? -21.96091 21.39668 -36.72256 1.000 33.54597 ? 26  THR   A N   1 
ATOM   181  C CA  . THR   A 1 26  ? -20.77594 21.97608 -37.33820 1.000 26.62556 ? 26  THR   A CA  1 
ATOM   182  C C   . THR   A 1 26  ? -19.61113 21.91868 -36.35868 1.000 29.96304 ? 26  THR   A C   1 
ATOM   183  O O   . THR   A 1 26  ? -19.76676 22.23694 -35.17574 1.000 28.66911 ? 26  THR   A O   1 
ATOM   184  C CB  . THR   A 1 26  ? -21.00755 23.44072 -37.75858 1.000 34.08538 ? 26  THR   A CB  1 
ATOM   185  O OG1 . THR   A 1 26  ? -22.08738 23.51853 -38.70312 1.000 38.38993 ? 26  THR   A OG1 1 
ATOM   186  C CG2 . THR   A 1 26  ? -19.75509 24.01981 -38.39265 1.000 29.82981 ? 26  THR   A CG2 1 
ATOM   187  N N   . LEU   A 1 27  ? -18.43853 21.52178 -36.84534 1.000 22.26341 ? 27  LEU   A N   1 
ATOM   188  C CA  . LEU   A 1 27  ? -17.24145 21.63865 -36.02425 1.000 22.66061 ? 27  LEU   A CA  1 
ATOM   189  C C   . LEU   A 1 27  ? -16.05578 21.88322 -36.95699 1.000 24.45376 ? 27  LEU   A C   1 
ATOM   190  O O   . LEU   A 1 27  ? -16.23036 22.19680 -38.13837 1.000 23.63000 ? 27  LEU   A O   1 
ATOM   191  C CB  . LEU   A 1 27  ? -17.08644 20.41300 -35.10944 1.000 23.05830 ? 27  LEU   A CB  1 
ATOM   192  C CG  . LEU   A 1 27  ? -17.42193 19.00401 -35.59219 1.000 24.01615 ? 27  LEU   A CG  1 
ATOM   193  C CD1 . LEU   A 1 27  ? -16.50060 18.61740 -36.73834 1.000 24.08026 ? 27  LEU   A CD1 1 
ATOM   194  C CD2 . LEU   A 1 27  ? -17.32796 17.97486 -34.45423 1.000 24.29016 ? 27  LEU   A CD2 1 
ATOM   195  N N   . ASN   A 1 28  ? -14.85177 21.77775 -36.41985 1.000 18.34459 ? 28  ASN   A N   1 
ATOM   196  C CA  . ASN   A 1 28  ? -13.63337 22.05289 -37.17504 1.000 19.86905 ? 28  ASN   A CA  1 
ATOM   197  C C   . ASN   A 1 28  ? -13.02353 20.78240 -37.74859 1.000 17.73555 ? 28  ASN   A C   1 
ATOM   198  O O   . ASN   A 1 28  ? -13.10287 19.70237 -37.15623 1.000 19.27282 ? 28  ASN   A O   1 
ATOM   199  C CB  . ASN   A 1 28  ? -12.59327 22.72735 -36.28285 1.000 22.13235 ? 28  ASN   A CB  1 
ATOM   200  C CG  . ASN   A 1 28  ? -13.13641 23.96078 -35.62103 1.000 21.72282 ? 28  ASN   A CG  1 
ATOM   201  O OD1 . ASN   A 1 28  ? -13.39279 24.97841 -36.28267 1.000 23.50730 ? 28  ASN   A OD1 1 
ATOM   202  N ND2 . ASN   A 1 28  ? -13.34683 23.87762 -34.29795 1.000 22.97998 ? 28  ASN   A ND2 1 
ATOM   203  N N   . GLY   A 1 29  ? -12.31988 20.94848 -38.87322 1.000 22.79641 ? 29  GLY   A N   1 
ATOM   204  C CA  . GLY   A 1 29  ? -11.53876 19.87528 -39.43687 1.000 22.47642 ? 29  GLY   A CA  1 
ATOM   205  C C   . GLY   A 1 29  ? -10.17546 20.37336 -39.85024 1.000 18.95086 ? 29  GLY   A C   1 
ATOM   206  O O   . GLY   A 1 29  ? -9.93686  21.57404 -39.99670 1.000 21.74649 ? 29  GLY   A O   1 
ATOM   207  N N   . LEU   A 1 30  ? -9.27209  19.41281 -40.04737 1.000 18.47394 ? 30  LEU   A N   1 
ATOM   208  C CA  . LEU   A 1 30  ? -7.88190  19.65114 -40.39854 1.000 19.07289 ? 30  LEU   A CA  1 
ATOM   209  C C   . LEU   A 1 30  ? -7.66845  19.12978 -41.81342 1.000 21.22597 ? 30  LEU   A C   1 
ATOM   210  O O   . LEU   A 1 30  ? -7.84831  17.93466 -42.05067 1.000 21.25588 ? 30  LEU   A O   1 
ATOM   211  C CB  . LEU   A 1 30  ? -6.94726  18.94787 -39.40154 1.000 21.32043 ? 30  LEU   A CB  1 
ATOM   212  C CG  . LEU   A 1 30  ? -5.44814  19.24957 -39.53647 1.000 20.92269 ? 30  LEU   A CG  1 
ATOM   213  C CD1 . LEU   A 1 30  ? -5.14790  20.72293 -39.19692 1.000 23.73196 ? 30  LEU   A CD1 1 
ATOM   214  C CD2 . LEU   A 1 30  ? -4.61183  18.33085 -38.65860 1.000 18.63690 ? 30  LEU   A CD2 1 
ATOM   215  N N   . TRP   A 1 31  ? -7.22904  20.01479 -42.72231 1.000 19.89183 ? 31  TRP   A N   1 
ATOM   216  C CA  . TRP   A 1 31  ? -7.15435  19.74621 -44.15940 1.000 20.51727 ? 31  TRP   A CA  1 
ATOM   217  C C   . TRP   A 1 31  ? -5.67672  19.62890 -44.54120 1.000 23.85522 ? 31  TRP   A C   1 
ATOM   218  O O   . TRP   A 1 31  ? -4.95336  20.63385 -44.58579 1.000 25.18914 ? 31  TRP   A O   1 
ATOM   219  C CB  . TRP   A 1 31  ? -7.88698  20.86572 -44.91931 1.000 22.88870 ? 31  TRP   A CB  1 
ATOM   220  C CG  . TRP   A 1 31  ? -7.94372  20.76583 -46.44418 1.000 21.98017 ? 31  TRP   A CG  1 
ATOM   221  C CD1 . TRP   A 1 31  ? -7.87515  19.62704 -47.20600 1.000 26.12280 ? 31  TRP   A CD1 1 
ATOM   222  C CD2 . TRP   A 1 31  ? -8.05471  21.85510 -47.37022 1.000 25.67842 ? 31  TRP   A CD2 1 
ATOM   223  N NE1 . TRP   A 1 31  ? -7.95296  19.94239 -48.54222 1.000 24.01312 ? 31  TRP   A NE1 1 
ATOM   224  C CE2 . TRP   A 1 31  ? -8.06098  21.30138 -48.67303 1.000 29.00467 ? 31  TRP   A CE2 1 
ATOM   225  C CE3 . TRP   A 1 31  ? -8.15384  23.24096 -47.22851 1.000 26.95325 ? 31  TRP   A CE3 1 
ATOM   226  C CZ2 . TRP   A 1 31  ? -8.17304  22.08856 -49.81700 1.000 25.15409 ? 31  TRP   A CZ2 1 
ATOM   227  C CZ3 . TRP   A 1 31  ? -8.26395  24.02191 -48.36017 1.000 32.76358 ? 31  TRP   A CZ3 1 
ATOM   228  C CH2 . TRP   A 1 31  ? -8.26864  23.43924 -49.64659 1.000 32.06784 ? 31  TRP   A CH2 1 
ATOM   229  N N   . LEU   A 1 32  ? -5.22518  18.40511 -44.81867 1.000 21.57172 ? 32  LEU   A N   1 
ATOM   230  C CA  . LEU   A 1 32  ? -3.83892  18.15190 -45.18783 1.000 23.88149 ? 32  LEU   A CA  1 
ATOM   231  C C   . LEU   A 1 32  ? -3.80403  17.36426 -46.49274 1.000 24.90265 ? 32  LEU   A C   1 
ATOM   232  O O   . LEU   A 1 32  ? -4.35623  16.26362 -46.56503 1.000 23.67103 ? 32  LEU   A O   1 
ATOM   233  C CB  . LEU   A 1 32  ? -3.11026  17.38631 -44.07888 1.000 21.32958 ? 32  LEU   A CB  1 
ATOM   234  C CG  . LEU   A 1 32  ? -3.08356  18.08235 -42.71373 1.000 23.14787 ? 32  LEU   A CG  1 
ATOM   235  C CD1 . LEU   A 1 32  ? -2.69639  17.08689 -41.59821 1.000 21.92877 ? 32  LEU   A CD1 1 
ATOM   236  C CD2 . LEU   A 1 32  ? -2.12825  19.27351 -42.77121 1.000 20.53847 ? 32  LEU   A CD2 1 
ATOM   237  N N   . ASP   A 1 33  ? -3.11955  17.90438 -47.50697 1.000 23.53692 ? 33  ASP   A N   1 
ATOM   238  C CA  . ASP   A 1 33  ? -3.17708  17.31032 -48.85066 1.000 28.65340 ? 33  ASP   A CA  1 
ATOM   239  C C   . ASP   A 1 33  ? -4.67008  17.22057 -49.18592 1.000 24.77522 ? 33  ASP   A C   1 
ATOM   240  O O   . ASP   A 1 33  ? -5.39355  18.20252 -48.99368 1.000 26.66837 ? 33  ASP   A O   1 
ATOM   241  C CB  . ASP   A 1 33  ? -2.40462  15.99354 -48.88543 1.000 28.93717 ? 33  ASP   A CB  1 
ATOM   242  C CG  . ASP   A 1 33  ? -0.92571  16.17173 -48.57825 1.000 30.22581 ? 33  ASP   A CG  1 
ATOM   243  O OD1 . ASP   A 1 33  ? -0.34869  17.19364 -48.98901 1.000 33.75288 ? 33  ASP   A OD1 1 
ATOM   244  O OD2 . ASP   A 1 33  ? -0.33906  15.27362 -47.93522 1.000 35.79005 ? 33  ASP   A OD2 1 
ATOM   245  N N   . ASP   A 1 34  ? -5.18242  16.08336 -49.64657 1.000 30.09690 ? 34  ASP   A N   1 
ATOM   246  C CA  . ASP   A 1 34  ? -6.57630  16.00437 -50.07624 1.000 28.45679 ? 34  ASP   A CA  1 
ATOM   247  C C   . ASP   A 1 34  ? -7.43766  15.23712 -49.08326 1.000 28.16737 ? 34  ASP   A C   1 
ATOM   248  O O   . ASP   A 1 34  ? -8.36717  14.52925 -49.47773 1.000 28.65883 ? 34  ASP   A O   1 
ATOM   249  C CB  . ASP   A 1 34  ? -6.69041  15.39068 -51.47897 1.000 28.68244 ? 34  ASP   A CB  1 
ATOM   250  C CG  . ASP   A 1 34  ? -6.25152  13.91617 -51.53522 1.000 36.22540 ? 34  ASP   A CG  1 
ATOM   251  O OD1 . ASP   A 1 34  ? -5.70336  13.38357 -50.54333 1.000 31.15533 ? 34  ASP   A OD1 1 
ATOM   252  O OD2 . ASP   A 1 34  ? -6.46445  13.27476 -52.58769 1.000 38.58175 ? 34  ASP   A OD2 1 
ATOM   253  N N   . VAL   A 1 35  ? -7.13671  15.34673 -47.78916 1.000 26.28826 ? 35  VAL   A N   1 
ATOM   254  C CA  . VAL   A 1 35  ? -7.92740  14.67966 -46.75601 1.000 22.55138 ? 35  VAL   A CA  1 
ATOM   255  C C   . VAL   A 1 35  ? -8.24949  15.68063 -45.65141 1.000 26.28375 ? 35  VAL   A C   1 
ATOM   256  O O   . VAL   A 1 35  ? -7.36801  16.43210 -45.22282 1.000 21.96679 ? 35  VAL   A O   1 
ATOM   257  C CB  . VAL   A 1 35  ? -7.19050  13.46567 -46.17024 1.000 21.93030 ? 35  VAL   A CB  1 
ATOM   258  C CG1 . VAL   A 1 35  ? -8.03477  12.82301 -45.07901 1.000 22.43331 ? 35  VAL   A CG1 1 
ATOM   259  C CG2 . VAL   A 1 35  ? -6.86906  12.46172 -47.29765 1.000 23.46984 ? 35  VAL   A CG2 1 
ATOM   260  N N   . VAL   A 1 36  ? -9.50796  15.69141 -45.20142 1.000 23.83495 ? 36  VAL   A N   1 
ATOM   261  C CA  . VAL   A 1 36  ? -9.93162  16.44553 -44.01698 1.000 24.05863 ? 36  VAL   A CA  1 
ATOM   262  C C   . VAL   A 1 36  ? -10.13692 15.47302 -42.85516 1.000 24.03021 ? 36  VAL   A C   1 
ATOM   263  O O   . VAL   A 1 36  ? -10.85450 14.47016 -42.99060 1.000 23.91309 ? 36  VAL   A O   1 
ATOM   264  C CB  . VAL   A 1 36  ? -11.21299 17.25762 -44.29449 1.000 22.88566 ? 36  VAL   A CB  1 
ATOM   265  C CG1 . VAL   A 1 36  ? -11.66190 17.97986 -43.03566 1.000 21.37757 ? 36  VAL   A CG1 1 
ATOM   266  C CG2 . VAL   A 1 36  ? -10.98256 18.29680 -45.39903 1.000 20.63655 ? 36  VAL   A CG2 1 
ATOM   267  N N   . TYR   A 1 37  ? -9.50633  15.76352 -41.70423 1.000 22.71758 ? 37  TYR   A N   1 
ATOM   268  C CA  . TYR   A 1 37  ? -9.66913  14.99353 -40.47139 1.000 17.69614 ? 37  TYR   A CA  1 
ATOM   269  C C   . TYR   A 1 37  ? -10.56702 15.75932 -39.49236 1.000 22.76390 ? 37  TYR   A C   1 
ATOM   270  O O   . TYR   A 1 37  ? -10.38143 16.96186 -39.29645 1.000 24.19959 ? 37  TYR   A O   1 
ATOM   271  C CB  . TYR   A 1 37  ? -8.29748  14.73547 -39.82357 1.000 22.79562 ? 37  TYR   A CB  1 
ATOM   272  C CG  . TYR   A 1 37  ? -7.27661  14.07157 -40.75813 1.000 19.57453 ? 37  TYR   A CG  1 
ATOM   273  C CD1 . TYR   A 1 37  ? -6.60616  14.81313 -41.73492 1.000 20.64914 ? 37  TYR   A CD1 1 
ATOM   274  C CD2 . TYR   A 1 37  ? -7.01267  12.70001 -40.66537 1.000 22.75892 ? 37  TYR   A CD2 1 
ATOM   275  C CE1 . TYR   A 1 37  ? -5.70508  14.19635 -42.62016 1.000 23.88876 ? 37  TYR   A CE1 1 
ATOM   276  C CE2 . TYR   A 1 37  ? -6.11102  12.08098 -41.52428 1.000 25.67939 ? 37  TYR   A CE2 1 
ATOM   277  C CZ  . TYR   A 1 37  ? -5.45626  12.84015 -42.49259 1.000 25.50513 ? 37  TYR   A CZ  1 
ATOM   278  O OH  . TYR   A 1 37  ? -4.56968  12.22397 -43.35338 1.000 30.71287 ? 37  TYR   A OH  1 
ATOM   279  N N   . CYS   A 1 38  ? -11.51662 15.07714 -38.85441 1.000 24.30185 ? 38  CYS   A N   1 
ATOM   280  C CA  . CYS   A 1 38  ? -12.37896 15.76891 -37.89722 1.000 22.41748 ? 38  CYS   A CA  1 
ATOM   281  C C   . CYS   A 1 38  ? -12.95006 14.74725 -36.91998 1.000 24.98305 ? 38  CYS   A C   1 
ATOM   282  O O   . CYS   A 1 38  ? -12.91978 13.54450 -37.19001 1.000 23.92101 ? 38  CYS   A O   1 
ATOM   283  C CB  . CYS   A 1 38  ? -13.49825 16.53765 -38.61433 1.000 26.69484 ? 38  CYS   A CB  1 
ATOM   284  S SG  . CYS   A 1 38  ? -14.79490 15.51129 -39.33966 1.000 27.88890 ? 38  CYS   A SG  1 
ATOM   285  N N   . PRO   A 1 39  ? -13.47615 15.20262 -35.77080 1.000 22.83782 ? 39  PRO   A N   1 
ATOM   286  C CA  . PRO   A 1 39  ? -14.08560 14.25922 -34.81747 1.000 20.35015 ? 39  PRO   A CA  1 
ATOM   287  C C   . PRO   A 1 39  ? -15.31970 13.58806 -35.40975 1.000 22.78015 ? 39  PRO   A C   1 
ATOM   288  O O   . PRO   A 1 39  ? -16.12226 14.21882 -36.09685 1.000 21.40586 ? 39  PRO   A O   1 
ATOM   289  C CB  . PRO   A 1 39  ? -14.44868 15.14928 -33.61951 1.000 24.04812 ? 39  PRO   A CB  1 
ATOM   290  C CG  . PRO   A 1 39  ? -13.56956 16.38395 -33.77600 1.000 21.29904 ? 39  PRO   A CG  1 
ATOM   291  C CD  . PRO   A 1 39  ? -13.51016 16.58279 -35.26707 1.000 22.45246 ? 39  PRO   A CD  1 
ATOM   292  N N   . ARG   A 1 40  ? -15.47633 12.29875 -35.11276 1.000 21.56149 ? 40  ARG   A N   1 
ATOM   293  C CA  . ARG   A 1 40  ? -16.57210 11.55020 -35.72393 1.000 22.85885 ? 40  ARG   A CA  1 
ATOM   294  C C   . ARG   A 1 40  ? -17.93359 11.96144 -35.17978 1.000 25.65543 ? 40  ARG   A C   1 
ATOM   295  O O   . ARG   A 1 40  ? -18.94164 11.72283 -35.85144 1.000 24.92515 ? 40  ARG   A O   1 
ATOM   296  C CB  . ARG   A 1 40  ? -16.34964 10.04755 -35.57443 1.000 24.90324 ? 40  ARG   A CB  1 
ATOM   297  C CG  . ARG   A 1 40  ? -16.36917 9.52075  -34.16359 1.000 26.12489 ? 40  ARG   A CG  1 
ATOM   298  C CD  . ARG   A 1 40  ? -16.24576 8.00591  -34.14513 1.000 28.04690 ? 40  ARG   A CD  1 
ATOM   299  N NE  . ARG   A 1 40  ? -16.10964 7.53089  -32.77701 1.000 23.90524 ? 40  ARG   A NE  1 
ATOM   300  C CZ  . ARG   A 1 40  ? -16.19000 6.26629  -32.39545 1.000 25.47566 ? 40  ARG   A CZ  1 
ATOM   301  N NH1 . ARG   A 1 40  ? -16.33432 5.28154  -33.27282 1.000 27.03803 ? 40  ARG   A NH1 1 
ATOM   302  N NH2 . ARG   A 1 40  ? -16.17597 5.98429  -31.09831 1.000 25.94091 ? 40  ARG   A NH2 1 
ATOM   303  N N   . HIS   A 1 41  ? -17.99886 12.66865 -34.04489 1.000 24.86707 ? 41  HIS   A N   1 
ATOM   304  C CA  . HIS   A 1 41  ? -19.33694 13.00898 -33.56969 1.000 24.20802 ? 41  HIS   A CA  1 
ATOM   305  C C   . HIS   A 1 41  ? -19.95304 14.17336 -34.33599 1.000 24.10064 ? 41  HIS   A C   1 
ATOM   306  O O   . HIS   A 1 41  ? -21.09074 14.54818 -34.03850 1.000 25.58396 ? 41  HIS   A O   1 
ATOM   307  C CB  . HIS   A 1 41  ? -19.33472 13.24053 -32.04880 1.000 21.05140 ? 41  HIS   A CB  1 
ATOM   308  C CG  . HIS   A 1 41  ? -18.62603 14.48005 -31.58362 1.000 23.97927 ? 41  HIS   A CG  1 
ATOM   309  N ND1 . HIS   A 1 41  ? -19.08944 15.75225 -31.84039 1.000 32.14304 ? 41  HIS   A ND1 1 
ATOM   310  C CD2 . HIS   A 1 41  ? -17.51375 14.63584 -30.82577 1.000 28.22362 ? 41  HIS   A CD2 1 
ATOM   311  C CE1 . HIS   A 1 41  ? -18.29707 16.63778 -31.26437 1.000 27.89389 ? 41  HIS   A CE1 1 
ATOM   312  N NE2 . HIS   A 1 41  ? -17.32592 15.98721 -30.65096 1.000 27.57268 ? 41  HIS   A NE2 1 
ATOM   313  N N   . VAL   A 1 42  ? -19.27918 14.68933 -35.36815 1.000 23.45375 ? 42  VAL   A N   1 
ATOM   314  C CA  . VAL   A 1 42  ? -19.95019 15.57702 -36.30956 1.000 22.41900 ? 42  VAL   A CA  1 
ATOM   315  C C   . VAL   A 1 42  ? -21.19460 14.90754 -36.88967 1.000 32.72849 ? 42  VAL   A C   1 
ATOM   316  O O   . VAL   A 1 42  ? -22.14305 15.60450 -37.27154 1.000 31.59613 ? 42  VAL   A O   1 
ATOM   317  C CB  . VAL   A 1 42  ? -18.98552 16.04593 -37.43082 1.000 24.30084 ? 42  VAL   A CB  1 
ATOM   318  C CG1 . VAL   A 1 42  ? -18.65324 14.91528 -38.37979 1.000 24.95621 ? 42  VAL   A CG1 1 
ATOM   319  C CG2 . VAL   A 1 42  ? -19.58882 17.20644 -38.22465 1.000 26.42668 ? 42  VAL   A CG2 1 
ATOM   320  N N   . ILE   A 1 43  ? -21.24431 13.56543 -36.91768 1.000 25.00453 ? 43  ILE   A N   1 
ATOM   321  C CA  . ILE   A 1 43  ? -22.37391 12.88045 -37.54986 1.000 33.07218 ? 43  ILE   A CA  1 
ATOM   322  C C   . ILE   A 1 43  ? -23.53338 12.62461 -36.59249 1.000 30.66061 ? 43  ILE   A C   1 
ATOM   323  O O   . ILE   A 1 43  ? -24.50912 11.97888 -36.99222 1.000 34.74097 ? 43  ILE   A O   1 
ATOM   324  C CB  . ILE   A 1 43  ? -21.97674 11.53187 -38.20416 1.000 29.14458 ? 43  ILE   A CB  1 
ATOM   325  C CG1 . ILE   A 1 43  ? -21.54416 10.49643 -37.16136 1.000 26.00244 ? 43  ILE   A CG1 1 
ATOM   326  C CG2 . ILE   A 1 43  ? -20.90050 11.74244 -39.27629 1.000 27.38523 ? 43  ILE   A CG2 1 
ATOM   327  C CD1 . ILE   A 1 43  ? -21.11511 9.11633  -37.77447 1.000 27.10805 ? 43  ILE   A CD1 1 
ATOM   328  N N   . CYS   A 1 44  ? -23.47765 13.12274 -35.36062 1.000 29.94689 ? 44  CYS   A N   1 
ATOM   329  C CA  . CYS   A 1 44  ? -24.57539 12.93968 -34.41849 1.000 33.83949 ? 44  CYS   A CA  1 
ATOM   330  C C   . CYS   A 1 44  ? -25.53716 14.11297 -34.44898 1.000 37.67183 ? 44  CYS   A C   1 
ATOM   331  O O   . CYS   A 1 44  ? -25.12457 15.27365 -34.54908 1.000 44.92451 ? 44  CYS   A O   1 
ATOM   332  C CB  . CYS   A 1 44  ? -24.07099 12.77214 -32.98441 1.000 40.26549 ? 44  CYS   A CB  1 
ATOM   333  S SG  . CYS   A 1 44  ? -22.95839 11.42286 -32.72799 1.000 37.50212 ? 44  CYS   A SG  1 
ATOM   334  N N   . THR   A 1 45  ? -26.82023 13.80243 -34.34096 1.000 39.05601 ? 45  THR   A N   1 
ATOM   335  C CA  . THR   A 1 45  ? -27.77892 14.81242 -33.94145 1.000 46.85732 ? 45  THR   A CA  1 
ATOM   336  C C   . THR   A 1 45  ? -27.59514 15.11413 -32.45950 1.000 54.93458 ? 45  THR   A C   1 
ATOM   337  O O   . THR   A 1 45  ? -26.88518 14.40292 -31.73447 1.000 48.22915 ? 45  THR   A O   1 
ATOM   338  C CB  . THR   A 1 45  ? -29.20851 14.34178 -34.20197 1.000 52.83637 ? 45  THR   A CB  1 
ATOM   339  O OG1 . THR   A 1 45  ? -29.38218 13.02561 -33.65891 1.000 48.41538 ? 45  THR   A OG1 1 
ATOM   340  C CG2 . THR   A 1 45  ? -29.50447 14.32231 -35.69864 1.000 52.20741 ? 45  THR   A CG2 1 
ATOM   341  N N   . SER   A 1 46  ? -28.25575 16.18053 -32.00290 1.000 57.24513 ? 46  SER   A N   1 
ATOM   342  C CA  . SER   A 1 46  ? -28.17721 16.53617 -30.59134 1.000 59.95967 ? 46  SER   A CA  1 
ATOM   343  C C   . SER   A 1 46  ? -28.79366 15.46751 -29.69898 1.000 60.10401 ? 46  SER   A C   1 
ATOM   344  O O   . SER   A 1 46  ? -28.56540 15.48007 -28.48458 1.000 67.62627 ? 46  SER   A O   1 
ATOM   345  C CB  . SER   A 1 46  ? -28.85464 17.88733 -30.36062 1.000 54.52136 ? 46  SER   A CB  1 
ATOM   346  O OG  . SER   A 1 46  ? -28.26904 18.54874 -29.25985 1.000 61.67034 ? 46  SER   A OG  1 
ATOM   347  N N   . GLU   A 1 47  ? -29.52954 14.52641 -30.28005 1.000 60.25441 ? 47  GLU   A N   1 
ATOM   348  C CA  . GLU   A 1 47  ? -30.23894 13.49321 -29.54851 1.000 64.30423 ? 47  GLU   A CA  1 
ATOM   349  C C   . GLU   A 1 47  ? -29.53604 12.13580 -29.59864 1.000 64.98238 ? 47  GLU   A C   1 
ATOM   350  O O   . GLU   A 1 47  ? -29.90294 11.23834 -28.83317 1.000 66.71695 ? 47  GLU   A O   1 
ATOM   351  C CB  . GLU   A 1 47  ? -31.66001 13.38977 -30.11701 1.000 74.96720 ? 47  GLU   A CB  1 
ATOM   352  C CG  . GLU   A 1 47  ? -32.75838 13.04862 -29.12096 1.000 85.30160 ? 47  GLU   A CG  1 
ATOM   353  C CD  . GLU   A 1 47  ? -33.12627 11.58355 -29.13222 1.000 92.57987 ? 47  GLU   A CD  1 
ATOM   354  O OE1 . GLU   A 1 47  ? -32.51667 10.82653 -29.91797 1.000 93.55231 ? 47  GLU   A OE1 1 
ATOM   355  O OE2 . GLU   A 1 47  ? -34.05359 11.19985 -28.38459 1.000 95.03353 ? 47  GLU   A OE2 1 
ATOM   356  N N   . ASP   A 1 48  ? -28.53501 11.96800 -30.47318 1.000 56.13960 ? 48  ASP   A N   1 
ATOM   357  C CA  . ASP   A 1 48  ? -27.74928 10.74106 -30.59055 1.000 51.22416 ? 48  ASP   A CA  1 
ATOM   358  C C   . ASP   A 1 48  ? -26.62801 10.65035 -29.57279 1.000 45.61764 ? 48  ASP   A C   1 
ATOM   359  O O   . ASP   A 1 48  ? -25.87866 9.66603  -29.57990 1.000 41.87292 ? 48  ASP   A O   1 
ATOM   360  C CB  . ASP   A 1 48  ? -27.10304 10.64802 -31.97334 1.000 50.63234 ? 48  ASP   A CB  1 
ATOM   361  C CG  . ASP   A 1 48  ? -28.00896 10.05432 -33.00179 1.000 53.19027 ? 48  ASP   A CG  1 
ATOM   362  O OD1 . ASP   A 1 48  ? -28.21708 10.72327 -34.04355 1.000 51.16262 ? 48  ASP   A OD1 1 
ATOM   363  O OD2 . ASP   A 1 48  ? -28.49120 8.92230  -32.76649 1.000 50.47114 ? 48  ASP   A OD2 1 
ATOM   364  N N   . MET   A 1 49  ? -26.48391 11.64903 -28.71393 1.000 52.52163 ? 49  MET   A N   1 
ATOM   365  C CA  . MET   A 1 49  ? -25.19512 11.89924 -28.09813 1.000 39.76579 ? 49  MET   A CA  1 
ATOM   366  C C   . MET   A 1 49  ? -24.98201 11.09520 -26.83439 1.000 33.53671 ? 49  MET   A C   1 
ATOM   367  O O   . MET   A 1 49  ? -23.82377 10.86539 -26.44910 1.000 28.65335 ? 49  MET   A O   1 
ATOM   368  C CB  . MET   A 1 49  ? -25.07595 13.39049 -27.82603 1.000 42.51111 ? 49  MET   A CB  1 
ATOM   369  C CG  . MET   A 1 49  ? -25.05613 14.15510 -29.12134 1.000 47.82753 ? 49  MET   A CG  1 
ATOM   370  S SD  . MET   A 1 49  ? -23.71211 15.30464 -29.27838 1.000 56.54651 ? 49  MET   A SD  1 
ATOM   371  C CE  . MET   A 1 49  ? -24.43303 16.69805 -28.41256 1.000 46.51928 ? 49  MET   A CE  1 
ATOM   372  N N   . LEU   A 1 50  ? -26.06585 10.63097 -26.20190 1.000 35.24447 ? 50  LEU   A N   1 
ATOM   373  C CA  . LEU   A 1 50  ? -25.92151 9.96082  -24.91573 1.000 34.44762 ? 50  LEU   A CA  1 
ATOM   374  C C   . LEU   A 1 50  ? -25.15846 8.65801  -25.07040 1.000 35.29198 ? 50  LEU   A C   1 
ATOM   375  O O   . LEU   A 1 50  ? -24.41443 8.25495  -24.16501 1.000 34.61410 ? 50  LEU   A O   1 
ATOM   376  C CB  . LEU   A 1 50  ? -27.27879 9.67095  -24.27334 1.000 30.71504 ? 50  LEU   A CB  1 
ATOM   377  C CG  . LEU   A 1 50  ? -27.88666 10.74827 -23.36844 1.000 39.18873 ? 50  LEU   A CG  1 
ATOM   378  C CD1 . LEU   A 1 50  ? -29.20303 10.26045 -22.75605 1.000 36.11948 ? 50  LEU   A CD1 1 
ATOM   379  C CD2 . LEU   A 1 50  ? -26.93389 11.31506 -22.33391 1.000 32.71708 ? 50  LEU   A CD2 1 
ATOM   380  N N   . ASN   A 1 51  ? -25.34949 7.97172  -26.20157 1.000 29.13260 ? 51  ASN   A N   1 
ATOM   381  C CA  . ASN   A 1 51  ? -24.65138 6.71294  -26.44459 1.000 34.05725 ? 51  ASN   A CA  1 
ATOM   382  C C   . ASN   A 1 51  ? -24.72254 6.36495  -27.92674 1.000 36.51312 ? 51  ASN   A C   1 
ATOM   383  O O   . ASN   A 1 51  ? -25.51187 5.50205  -28.32956 1.000 34.01971 ? 51  ASN   A O   1 
ATOM   384  C CB  . ASN   A 1 51  ? -25.25031 5.56127  -25.63955 1.000 39.26142 ? 51  ASN   A CB  1 
ATOM   385  C CG  . ASN   A 1 51  ? -24.24565 4.46893  -25.39641 1.000 43.70052 ? 51  ASN   A CG  1 
ATOM   386  O OD1 . ASN   A 1 51  ? -23.13688 4.49678  -25.94938 1.000 41.12771 ? 51  ASN   A OD1 1 
ATOM   387  N ND2 . ASN   A 1 51  ? -24.62238 3.48251  -24.59440 1.000 53.17389 ? 51  ASN   A ND2 1 
ATOM   388  N N   . PRO   A 1 52  ? -23.92768 7.00857  -28.76521 1.000 30.35844 ? 52  PRO   A N   1 
ATOM   389  C CA  . PRO   A 1 52  ? -24.09508 6.83657  -30.20905 1.000 28.72570 ? 52  PRO   A CA  1 
ATOM   390  C C   . PRO   A 1 52  ? -23.49487 5.53028  -30.69575 1.000 32.94298 ? 52  PRO   A C   1 
ATOM   391  O O   . PRO   A 1 52  ? -22.51500 5.01715  -30.14841 1.000 23.07820 ? 52  PRO   A O   1 
ATOM   392  C CB  . PRO   A 1 52  ? -23.34607 8.03926  -30.79685 1.000 30.01064 ? 52  PRO   A CB  1 
ATOM   393  C CG  . PRO   A 1 52  ? -22.33818 8.38235  -29.75790 1.000 31.21643 ? 52  PRO   A CG  1 
ATOM   394  C CD  . PRO   A 1 52  ? -22.90148 8.00522  -28.42403 1.000 30.51809 ? 52  PRO   A CD  1 
ATOM   395  N N   . ASN   A 1 53  ? -24.13599 4.97485  -31.72186 1.000 32.51725 ? 53  ASN   A N   1 
ATOM   396  C CA  . ASN   A 1 53  ? -23.56446 3.89516  -32.52798 1.000 29.93787 ? 53  ASN   A CA  1 
ATOM   397  C C   . ASN   A 1 53  ? -23.01260 4.57826  -33.77359 1.000 26.94099 ? 53  ASN   A C   1 
ATOM   398  O O   . ASN   A 1 53  ? -23.73345 4.80904  -34.74345 1.000 27.51009 ? 53  ASN   A O   1 
ATOM   399  C CB  . ASN   A 1 53  ? -24.60144 2.82326  -32.85865 1.000 29.56493 ? 53  ASN   A CB  1 
ATOM   400  C CG  . ASN   A 1 53  ? -24.00194 1.62697  -33.61150 1.000 29.65564 ? 53  ASN   A CG  1 
ATOM   401  O OD1 . ASN   A 1 53  ? -22.97734 1.74971  -34.31250 1.000 24.32446 ? 53  ASN   A OD1 1 
ATOM   402  N ND2 . ASN   A 1 53  ? -24.65062 0.46624  -33.48849 1.000 24.84626 ? 53  ASN   A ND2 1 
ATOM   403  N N   . TYR   A 1 54  ? -21.71042 4.90051  -33.73981 1.000 26.98272 ? 54  TYR   A N   1 
ATOM   404  C CA  . TYR   A 1 54  ? -21.11811 5.69617  -34.81449 1.000 27.17130 ? 54  TYR   A CA  1 
ATOM   405  C C   . TYR   A 1 54  ? -21.09459 4.93563  -36.13442 1.000 26.51125 ? 54  TYR   A C   1 
ATOM   406  O O   . TYR   A 1 54  ? -21.30767 5.52378  -37.20072 1.000 24.08090 ? 54  TYR   A O   1 
ATOM   407  C CB  . TYR   A 1 54  ? -19.70152 6.12842  -34.43167 1.000 29.58897 ? 54  TYR   A CB  1 
ATOM   408  C CG  . TYR   A 1 54  ? -19.68815 7.20134  -33.37020 1.000 26.36998 ? 54  TYR   A CG  1 
ATOM   409  C CD1 . TYR   A 1 54  ? -20.01584 8.51336  -33.69408 1.000 26.51303 ? 54  TYR   A CD1 1 
ATOM   410  C CD2 . TYR   A 1 54  ? -19.35366 6.91396  -32.05480 1.000 28.22832 ? 54  TYR   A CD2 1 
ATOM   411  C CE1 . TYR   A 1 54  ? -20.01373 9.51417  -32.73526 1.000 26.41216 ? 54  TYR   A CE1 1 
ATOM   412  C CE2 . TYR   A 1 54  ? -19.34229 7.91795  -31.07787 1.000 26.82823 ? 54  TYR   A CE2 1 
ATOM   413  C CZ  . TYR   A 1 54  ? -19.67462 9.21714  -31.43314 1.000 26.69223 ? 54  TYR   A CZ  1 
ATOM   414  O OH  . TYR   A 1 54  ? -19.68390 10.22492 -30.47879 1.000 25.70020 ? 54  TYR   A OH  1 
ATOM   415  N N   . GLU   A 1 55  ? -20.79630 3.64111  -36.08878 1.000 26.10887 ? 55  GLU   A N   1 
ATOM   416  C CA  . GLU   A 1 55  ? -20.73718 2.86685  -37.32432 1.000 31.01193 ? 55  GLU   A CA  1 
ATOM   417  C C   . GLU   A 1 55  ? -22.10664 2.83763  -37.99227 1.000 28.27653 ? 55  GLU   A C   1 
ATOM   418  O O   . GLU   A 1 55  ? -22.21849 2.97006  -39.21884 1.000 30.30780 ? 55  GLU   A O   1 
ATOM   419  C CB  . GLU   A 1 55  ? -20.23069 1.45531  -37.00981 1.000 29.36277 ? 55  GLU   A CB  1 
ATOM   420  C CG  . GLU   A 1 55  ? -18.75433 1.43393  -36.62028 1.000 31.52495 ? 55  GLU   A CG  1 
ATOM   421  C CD  . GLU   A 1 55  ? -18.57026 1.44729  -35.10131 1.000 36.11442 ? 55  GLU   A CD  1 
ATOM   422  O OE1 . GLU   A 1 55  ? -19.48671 1.93505  -34.38792 1.000 33.45004 ? 55  GLU   A OE1 1 
ATOM   423  O OE2 . GLU   A 1 55  ? -17.49756 1.02168  -34.61452 1.000 35.18567 ? 55  GLU   A OE2 1 
ATOM   424  N N   . ASP   A 1 56  ? -23.16114 2.67811  -37.19274 1.000 27.27904 ? 56  ASP   A N   1 
ATOM   425  C CA  . ASP   A 1 56  ? -24.52271 2.72089  -37.71838 1.000 27.04985 ? 56  ASP   A CA  1 
ATOM   426  C C   . ASP   A 1 56  ? -24.85794 4.09270  -38.30244 1.000 30.78941 ? 56  ASP   A C   1 
ATOM   427  O O   . ASP   A 1 56  ? -25.39931 4.18802  -39.41069 1.000 32.21219 ? 56  ASP   A O   1 
ATOM   428  C CB  . ASP   A 1 56  ? -25.52285 2.33457  -36.62232 1.000 28.07851 ? 56  ASP   A CB  1 
ATOM   429  C CG  . ASP   A 1 56  ? -26.96391 2.33790  -37.12106 1.000 37.34887 ? 56  ASP   A CG  1 
ATOM   430  O OD1 . ASP   A 1 56  ? -27.21680 1.70769  -38.17039 1.000 40.33498 ? 56  ASP   A OD1 1 
ATOM   431  O OD2 . ASP   A 1 56  ? -27.83987 2.94565  -36.46495 1.000 36.96659 ? 56  ASP   A OD2 1 
ATOM   432  N N   . LEU   A 1 57  ? -24.55218 5.17343  -37.57010 1.000 26.53338 ? 57  LEU   A N   1 
ATOM   433  C CA  . LEU   A 1 57  ? -24.82021 6.51045  -38.09601 1.000 27.41868 ? 57  LEU   A CA  1 
ATOM   434  C C   . LEU   A 1 57  ? -24.06885 6.76325  -39.39866 1.000 29.33761 ? 57  LEU   A C   1 
ATOM   435  O O   . LEU   A 1 57  ? -24.60706 7.40529  -40.31231 1.000 27.56893 ? 57  LEU   A O   1 
ATOM   436  C CB  . LEU   A 1 57  ? -24.44723 7.57482  -37.05429 1.000 28.54349 ? 57  LEU   A CB  1 
ATOM   437  C CG  . LEU   A 1 57  ? -25.31604 7.62805  -35.79350 1.000 28.78728 ? 57  LEU   A CG  1 
ATOM   438  C CD1 . LEU   A 1 57  ? -24.80799 8.68751  -34.84005 1.000 32.81739 ? 57  LEU   A CD1 1 
ATOM   439  C CD2 . LEU   A 1 57  ? -26.75321 7.91544  -36.16474 1.000 33.91777 ? 57  LEU   A CD2 1 
ATOM   440  N N   . LEU   A 1 58  ? -22.83932 6.25932  -39.51442 1.000 25.47619 ? 58  LEU   A N   1 
ATOM   441  C CA  . LEU   A 1 58  ? -22.04174 6.58653  -40.69277 1.000 29.54780 ? 58  LEU   A CA  1 
ATOM   442  C C   . LEU   A 1 58  ? -22.54587 5.85931  -41.93683 1.000 32.81548 ? 58  LEU   A C   1 
ATOM   443  O O   . LEU   A 1 58  ? -22.39722 6.36924  -43.05851 1.000 29.84544 ? 58  LEU   A O   1 
ATOM   444  C CB  . LEU   A 1 58  ? -20.55497 6.26096  -40.44735 1.000 26.52198 ? 58  LEU   A CB  1 
ATOM   445  C CG  . LEU   A 1 58  ? -19.54222 6.71728  -41.50546 1.000 26.57417 ? 58  LEU   A CG  1 
ATOM   446  C CD1 . LEU   A 1 58  ? -19.62012 8.22048  -41.74653 1.000 28.33647 ? 58  LEU   A CD1 1 
ATOM   447  C CD2 . LEU   A 1 58  ? -18.10513 6.27295  -41.18042 1.000 29.97842 ? 58  LEU   A CD2 1 
ATOM   448  N N   . ILE   A 1 59  ? -23.13832 4.67351  -41.77960 1.000 33.98394 ? 59  ILE   A N   1 
ATOM   449  C CA  . ILE   A 1 59  ? -23.49066 3.92661  -42.98541 1.000 36.63941 ? 59  ILE   A CA  1 
ATOM   450  C C   . ILE   A 1 59  ? -24.67200 4.60195  -43.67361 1.000 39.46215 ? 59  ILE   A C   1 
ATOM   451  O O   . ILE   A 1 59  ? -24.86866 4.42435  -44.88395 1.000 39.16396 ? 59  ILE   A O   1 
ATOM   452  C CB  . ILE   A 1 59  ? -23.75550 2.43649  -42.67089 1.000 37.32280 ? 59  ILE   A CB  1 
ATOM   453  C CG1 . ILE   A 1 59  ? -24.12410 1.66597  -43.93689 1.000 44.46452 ? 59  ILE   A CG1 1 
ATOM   454  C CG2 . ILE   A 1 59  ? -24.90300 2.28119  -41.72669 1.000 42.02907 ? 59  ILE   A CG2 1 
ATOM   455  C CD1 . ILE   A 1 59  ? -23.05656 1.76550  -45.03817 1.000 41.91416 ? 59  ILE   A CD1 1 
ATOM   456  N N   . ARG   A 1 60  ? -25.43271 5.42895  -42.93484 1.000 34.97395 ? 60  ARG   A N   1 
ATOM   457  C CA  . ARG   A 1 60  ? -26.49775 6.23598  -43.52103 1.000 38.02518 ? 60  ARG   A CA  1 
ATOM   458  C C   . ARG   A 1 60  ? -25.99353 7.48693  -44.25671 1.000 40.21475 ? 60  ARG   A C   1 
ATOM   459  O O   . ARG   A 1 60  ? -26.74069 8.04726  -45.06920 1.000 44.03449 ? 60  ARG   A O   1 
ATOM   460  C CB  . ARG   A 1 60  ? -27.50470 6.65117  -42.43672 1.000 39.35945 ? 60  ARG   A CB  1 
ATOM   461  C CG  . ARG   A 1 60  ? -28.48908 5.55707  -41.96332 1.000 53.04282 ? 60  ARG   A CG  1 
ATOM   462  C CD  . ARG   A 1 60  ? -28.13166 5.00318  -40.57478 1.000 49.80908 ? 60  ARG   A CD  1 
ATOM   463  N NE  . ARG   A 1 60  ? -29.20067 4.26006  -39.90542 1.000 51.17375 ? 60  ARG   A NE  1 
ATOM   464  C CZ  . ARG   A 1 60  ? -29.77668 3.15306  -40.36393 1.000 62.41754 ? 60  ARG   A CZ  1 
ATOM   465  N NH1 . ARG   A 1 60  ? -29.41173 2.60094  -41.51269 1.000 59.17202 ? 60  ARG   A NH1 1 
ATOM   466  N NH2 . ARG   A 1 60  ? -30.74176 2.57869  -39.64648 1.000 66.01990 ? 60  ARG   A NH2 1 
ATOM   467  N N   . LYS   A 1 61  ? -24.76462 7.94819  -44.00816 1.000 38.28515 ? 61  LYS   A N   1 
ATOM   468  C CA  . LYS   A 1 61  ? -24.23454 9.10985  -44.72457 1.000 36.29014 ? 61  LYS   A CA  1 
ATOM   469  C C   . LYS   A 1 61  ? -23.51732 8.70167  -46.01089 1.000 38.18748 ? 61  LYS   A C   1 
ATOM   470  O O   . LYS   A 1 61  ? -22.84357 7.66460  -46.08189 1.000 36.56763 ? 61  LYS   A O   1 
ATOM   471  C CB  . LYS   A 1 61  ? -23.24866 9.94226  -43.87438 1.000 35.12152 ? 61  LYS   A CB  1 
ATOM   472  C CG  . LYS   A 1 61  ? -23.59811 10.25433 -42.42438 1.000 36.20538 ? 61  LYS   A CG  1 
ATOM   473  C CD  . LYS   A 1 61  ? -24.99811 10.82323 -42.27376 1.000 42.17490 ? 61  LYS   A CD  1 
ATOM   474  C CE  . LYS   A 1 61  ? -25.28778 11.13781 -40.81171 1.000 42.60646 ? 61  LYS   A CE  1 
ATOM   475  N NZ  . LYS   A 1 61  ? -26.04831 9.99950  -40.17743 1.000 48.12058 ? 61  LYS   A NZ  1 
ATOM   476  N N   . SER   A 1 62  ? -23.65358 9.55809  -47.02077 1.000 37.18356 ? 62  SER   A N   1 
ATOM   477  C CA  . SER   A 1 62  ? -22.88790 9.52686  -48.25922 1.000 37.06737 ? 62  SER   A CA  1 
ATOM   478  C C   . SER   A 1 62  ? -22.04966 10.79773 -48.36312 1.000 34.06026 ? 62  SER   A C   1 
ATOM   479  O O   . SER   A 1 62  ? -22.22811 11.74628 -47.58881 1.000 33.84060 ? 62  SER   A O   1 
ATOM   480  C CB  . SER   A 1 62  ? -23.81446 9.42512  -49.47702 1.000 38.06344 ? 62  SER   A CB  1 
ATOM   481  O OG  . SER   A 1 62  ? -24.50075 10.65314 -49.66535 1.000 35.30911 ? 62  SER   A OG  1 
ATOM   482  N N   . ASN   A 1 63  ? -21.16321 10.82385 -49.37307 1.000 34.44568 ? 63  ASN   A N   1 
ATOM   483  C CA  . ASN   A 1 63  ? -20.19151 11.91269 -49.49863 1.000 33.68370 ? 63  ASN   A CA  1 
ATOM   484  C C   . ASN   A 1 63  ? -20.85805 13.27812 -49.46702 1.000 29.41162 ? 63  ASN   A C   1 
ATOM   485  O O   . ASN   A 1 63  ? -20.35942 14.20405 -48.81933 1.000 30.10846 ? 63  ASN   A O   1 
ATOM   486  C CB  . ASN   A 1 63  ? -19.38398 11.78102 -50.79211 1.000 30.49892 ? 63  ASN   A CB  1 
ATOM   487  C CG  . ASN   A 1 63  ? -18.45328 10.59720 -50.78153 1.000 32.86261 ? 63  ASN   A CG  1 
ATOM   488  O OD1 . ASN   A 1 63  ? -17.97476 10.18424 -49.73288 1.000 34.43703 ? 63  ASN   A OD1 1 
ATOM   489  N ND2 . ASN   A 1 63  ? -18.13976 10.07708 -51.96467 1.000 31.43068 ? 63  ASN   A ND2 1 
ATOM   490  N N   . HIS   A 1 64  ? -21.98301 13.43309 -50.17029 1.000 30.93646 ? 64  HIS   A N   1 
ATOM   491  C CA  . HIS   A 1 64  ? -22.60152 14.75251 -50.31090 1.000 32.42592 ? 64  HIS   A CA  1 
ATOM   492  C C   . HIS   A 1 64  ? -23.18432 15.26918 -49.00184 1.000 30.53079 ? 64  HIS   A C   1 
ATOM   493  O O   . HIS   A 1 64  ? -23.45354 16.47118 -48.89212 1.000 32.92852 ? 64  HIS   A O   1 
ATOM   494  C CB  . HIS   A 1 64  ? -23.70990 14.71392 -51.37864 1.000 35.12890 ? 64  HIS   A CB  1 
ATOM   495  C CG  . HIS   A 1 64  ? -24.20949 16.06831 -51.80015 1.000 38.23996 ? 64  HIS   A CG  1 
ATOM   496  N ND1 . HIS   A 1 64  ? -23.50262 16.89404 -52.65180 1.000 40.31039 ? 64  HIS   A ND1 1 
ATOM   497  C CD2 . HIS   A 1 64  ? -25.34686 16.73721 -51.48923 1.000 29.05931 ? 64  HIS   A CD2 1 
ATOM   498  C CE1 . HIS   A 1 64  ? -24.18725 18.00546 -52.85227 1.000 31.85713 ? 64  HIS   A CE1 1 
ATOM   499  N NE2 . HIS   A 1 64  ? -25.30897 17.93603 -52.15751 1.000 37.45983 ? 64  HIS   A NE2 1 
ATOM   500  N N   . ASN   A 1 65  ? -23.38825 14.40246 -48.01418 1.000 31.01353 ? 65  ASN   A N   1 
ATOM   501  C CA  . ASN   A 1 65  ? -23.93284 14.86126 -46.73975 1.000 31.18559 ? 65  ASN   A CA  1 
ATOM   502  C C   . ASN   A 1 65  ? -22.91995 15.64266 -45.90668 1.000 32.31776 ? 65  ASN   A C   1 
ATOM   503  O O   . ASN   A 1 65  ? -23.28911 16.15304 -44.84516 1.000 32.29328 ? 65  ASN   A O   1 
ATOM   504  C CB  . ASN   A 1 65  ? -24.43966 13.68792 -45.89632 1.000 29.55390 ? 65  ASN   A CB  1 
ATOM   505  C CG  . ASN   A 1 65  ? -25.37540 12.74961 -46.66763 1.000 40.93645 ? 65  ASN   A CG  1 
ATOM   506  O OD1 . ASN   A 1 65  ? -25.54700 11.58829 -46.29154 1.000 35.38397 ? 65  ASN   A OD1 1 
ATOM   507  N ND2 . ASN   A 1 65  ? -25.96958 13.24717 -47.75386 1.000 35.20033 ? 65  ASN   A ND2 1 
ATOM   508  N N   . PHE   A 1 66  ? -21.66448 15.71872 -46.33392 1.000 28.48551 ? 66  PHE   A N   1 
ATOM   509  C CA  . PHE   A 1 66  ? -20.60924 16.40385 -45.58683 1.000 27.38795 ? 66  PHE   A CA  1 
ATOM   510  C C   . PHE   A 1 66  ? -20.29405 17.70584 -46.31455 1.000 27.99003 ? 66  PHE   A C   1 
ATOM   511  O O   . PHE   A 1 66  ? -19.79751 17.69189 -47.44863 1.000 28.23672 ? 66  PHE   A O   1 
ATOM   512  C CB  . PHE   A 1 66  ? -19.36803 15.52513 -45.46702 1.000 27.81021 ? 66  PHE   A CB  1 
ATOM   513  C CG  . PHE   A 1 66  ? -19.57365 14.30619 -44.61913 1.000 35.67197 ? 66  PHE   A CG  1 
ATOM   514  C CD1 . PHE   A 1 66  ? -19.49655 14.37390 -43.24088 1.000 28.36488 ? 66  PHE   A CD1 1 
ATOM   515  C CD2 . PHE   A 1 66  ? -19.82314 13.07096 -45.21622 1.000 33.15763 ? 66  PHE   A CD2 1 
ATOM   516  C CE1 . PHE   A 1 66  ? -19.67662 13.24789 -42.47015 1.000 31.62180 ? 66  PHE   A CE1 1 
ATOM   517  C CE2 . PHE   A 1 66  ? -20.00192 11.93298 -44.43936 1.000 36.14755 ? 66  PHE   A CE2 1 
ATOM   518  C CZ  . PHE   A 1 66  ? -19.93045 12.02358 -43.06487 1.000 32.88193 ? 66  PHE   A CZ  1 
ATOM   519  N N   . LEU   A 1 67  ? -20.63768 18.82454 -45.68938 1.000 24.54436 ? 67  LEU   A N   1 
ATOM   520  C CA  . LEU   A 1 67  ? -20.32665 20.14779 -46.21143 1.000 29.39565 ? 67  LEU   A CA  1 
ATOM   521  C C   . LEU   A 1 67  ? -19.01215 20.62146 -45.61789 1.000 30.88275 ? 67  LEU   A C   1 
ATOM   522  O O   . LEU   A 1 67  ? -18.94122 20.91765 -44.42573 1.000 29.21388 ? 67  LEU   A O   1 
ATOM   523  C CB  . LEU   A 1 67  ? -21.43381 21.13186 -45.86506 1.000 30.85950 ? 67  LEU   A CB  1 
ATOM   524  C CG  . LEU   A 1 67  ? -21.37282 22.49740 -46.54070 1.000 34.59319 ? 67  LEU   A CG  1 
ATOM   525  C CD1 . LEU   A 1 67  ? -21.12355 22.45291 -48.03692 1.000 39.24461 ? 67  LEU   A CD1 1 
ATOM   526  C CD2 . LEU   A 1 67  ? -22.60863 23.27786 -46.17092 1.000 39.05635 ? 67  LEU   A CD2 1 
ATOM   527  N N   . VAL   A 1 68  ? -17.98720 20.73160 -46.44774 1.000 25.90693 ? 68  VAL   A N   1 
ATOM   528  C CA  . VAL   A 1 68  ? -16.68404 21.21136 -46.01250 1.000 27.95803 ? 68  VAL   A CA  1 
ATOM   529  C C   . VAL   A 1 68  ? -16.43509 22.56534 -46.66543 1.000 33.63213 ? 68  VAL   A C   1 
ATOM   530  O O   . VAL   A 1 68  ? -16.60050 22.71558 -47.88436 1.000 32.58804 ? 68  VAL   A O   1 
ATOM   531  C CB  . VAL   A 1 68  ? -15.57524 20.20793 -46.36449 1.000 25.11133 ? 68  VAL   A CB  1 
ATOM   532  C CG1 . VAL   A 1 68  ? -14.24193 20.67895 -45.81062 1.000 32.60198 ? 68  VAL   A CG1 1 
ATOM   533  C CG2 . VAL   A 1 68  ? -15.91249 18.83167 -45.84679 1.000 24.98927 ? 68  VAL   A CG2 1 
ATOM   534  N N   . GLN   A 1 69  ? -16.05058 23.55549 -45.85880 1.000 24.95860 ? 69  GLN   A N   1 
ATOM   535  C CA  . GLN   A 1 69  ? -15.78509 24.89254 -46.36980 1.000 30.31901 ? 69  GLN   A CA  1 
ATOM   536  C C   . GLN   A 1 69  ? -14.42438 25.35714 -45.88490 1.000 32.30878 ? 69  GLN   A C   1 
ATOM   537  O O   . GLN   A 1 69  ? -14.13360 25.28754 -44.68726 1.000 29.39454 ? 69  GLN   A O   1 
ATOM   538  C CB  . GLN   A 1 69  ? -16.89556 25.85175 -45.93594 1.000 34.99901 ? 69  GLN   A CB  1 
ATOM   539  C CG  . GLN   A 1 69  ? -18.22803 25.52304 -46.61232 1.000 38.38340 ? 69  GLN   A CG  1 
ATOM   540  C CD  . GLN   A 1 69  ? -19.41000 26.29875 -46.03783 1.000 42.71945 ? 69  GLN   A CD  1 
ATOM   541  O OE1 . GLN   A 1 69  ? -19.89617 27.24653 -46.65410 1.000 47.33844 ? 69  GLN   A OE1 1 
ATOM   542  N NE2 . GLN   A 1 69  ? -19.90773 25.86141 -44.86996 1.000 43.55475 ? 69  GLN   A NE2 1 
ATOM   543  N N   . ALA   A 1 70  ? -13.57916 25.77173 -46.82551 1.000 30.22195 ? 70  ALA   A N   1 
ATOM   544  C CA  . ALA   A 1 70  ? -12.29443 26.41468 -46.55460 1.000 31.67191 ? 70  ALA   A CA  1 
ATOM   545  C C   . ALA   A 1 70  ? -12.49600 27.88828 -46.87085 1.000 36.69700 ? 70  ALA   A C   1 
ATOM   546  O O   . ALA   A 1 70  ? -12.40546 28.30115 -48.02978 1.000 36.14888 ? 70  ALA   A O   1 
ATOM   547  C CB  . ALA   A 1 70  ? -11.16409 25.80260 -47.38499 1.000 27.02993 ? 70  ALA   A CB  1 
ATOM   548  N N   . GLY   A 1 71  ? -12.79986 28.67253 -45.84244 1.000 35.68543 ? 71  GLY   A N   1 
ATOM   549  C CA  . GLY   A 1 71  ? -13.18064 30.05569 -46.08087 1.000 41.10601 ? 71  GLY   A CA  1 
ATOM   550  C C   . GLY   A 1 71  ? -14.54367 30.08914 -46.74210 1.000 45.91454 ? 71  GLY   A C   1 
ATOM   551  O O   . GLY   A 1 71  ? -15.50300 29.45588 -46.27933 1.000 42.71129 ? 71  GLY   A O   1 
ATOM   552  N N   . ASN   A 1 72  ? -14.62834 30.81678 -47.85648 1.000 51.27584 ? 72  ASN   A N   1 
ATOM   553  C CA  . ASN   A 1 72  ? -15.85094 30.92307 -48.64144 1.000 59.08336 ? 72  ASN   A CA  1 
ATOM   554  C C   . ASN   A 1 72  ? -15.91287 29.92292 -49.78687 1.000 53.65128 ? 72  ASN   A C   1 
ATOM   555  O O   . ASN   A 1 72  ? -16.68353 30.12734 -50.73142 1.000 55.47515 ? 72  ASN   A O   1 
ATOM   556  C CB  . ASN   A 1 72  ? -16.00525 32.34385 -49.18813 1.000 57.62970 ? 72  ASN   A CB  1 
ATOM   557  C CG  . ASN   A 1 72  ? -16.91739 33.19774 -48.32926 1.000 67.59923 ? 72  ASN   A CG  1 
ATOM   558  O OD1 . ASN   A 1 72  ? -17.03559 32.98306 -47.11994 1.000 59.56624 ? 72  ASN   A OD1 1 
ATOM   559  N ND2 . ASN   A 1 72  ? -17.57449 34.17151 -48.95248 1.000 78.01119 ? 72  ASN   A ND2 1 
ATOM   560  N N   . VAL   A 1 73  ? -15.12520 28.85532 -49.72938 1.000 45.45176 ? 73  VAL   A N   1 
ATOM   561  C CA  . VAL   A 1 73  ? -15.01672 27.89457 -50.82148 1.000 42.69159 ? 73  VAL   A CA  1 
ATOM   562  C C   . VAL   A 1 73  ? -15.47559 26.54321 -50.29980 1.000 40.86355 ? 73  VAL   A C   1 
ATOM   563  O O   . VAL   A 1 73  ? -14.93424 26.04348 -49.30829 1.000 37.03538 ? 73  VAL   A O   1 
ATOM   564  C CB  . VAL   A 1 73  ? -13.57951 27.79665 -51.36182 1.000 43.47842 ? 73  VAL   A CB  1 
ATOM   565  C CG1 . VAL   A 1 73  ? -13.48448 26.73339 -52.45305 1.000 44.50663 ? 73  VAL   A CG1 1 
ATOM   566  C CG2 . VAL   A 1 73  ? -13.09654 29.14660 -51.85802 1.000 51.28876 ? 73  VAL   A CG2 1 
ATOM   567  N N   . GLN   A 1 74  ? -16.45216 25.94203 -50.96963 1.000 38.30943 ? 74  GLN   A N   1 
ATOM   568  C CA  . GLN   A 1 74  ? -16.81877 24.57575 -50.64673 1.000 36.93328 ? 74  GLN   A CA  1 
ATOM   569  C C   . GLN   A 1 74  ? -15.78185 23.62504 -51.22967 1.000 36.32228 ? 74  GLN   A C   1 
ATOM   570  O O   . GLN   A 1 74  ? -15.24647 23.85907 -52.31687 1.000 41.26433 ? 74  GLN   A O   1 
ATOM   571  C CB  . GLN   A 1 74  ? -18.22238 24.24805 -51.17107 1.000 36.00841 ? 74  GLN   A CB  1 
ATOM   572  C CG  . GLN   A 1 74  ? -18.63975 22.79593 -50.95188 1.000 36.47578 ? 74  GLN   A CG  1 
ATOM   573  C CD  . GLN   A 1 74  ? -20.08655 22.52868 -51.30580 1.000 42.25542 ? 74  GLN   A CD  1 
ATOM   574  O OE1 . GLN   A 1 74  ? -20.82036 23.43199 -51.70742 1.000 42.42348 ? 74  GLN   A OE1 1 
ATOM   575  N NE2 . GLN   A 1 74  ? -20.50140 21.27494 -51.17603 1.000 39.01438 ? 74  GLN   A NE2 1 
ATOM   576  N N   . LEU   A 1 75  ? -15.46793 22.57513 -50.47699 1.000 31.02629 ? 75  LEU   A N   1 
ATOM   577  C CA  . LEU   A 1 75  ? -14.63403 21.46811 -50.93615 1.000 34.08376 ? 75  LEU   A CA  1 
ATOM   578  C C   . LEU   A 1 75  ? -15.52584 20.25426 -51.15349 1.000 34.42129 ? 75  LEU   A C   1 
ATOM   579  O O   . LEU   A 1 75  ? -16.20326 19.79564 -50.22401 1.000 37.61250 ? 75  LEU   A O   1 
ATOM   580  C CB  . LEU   A 1 75  ? -13.52460 21.13847 -49.93233 1.000 32.17078 ? 75  LEU   A CB  1 
ATOM   581  C CG  . LEU   A 1 75  ? -12.29508 22.03846 -49.79927 1.000 40.13306 ? 75  LEU   A CG  1 
ATOM   582  C CD1 . LEU   A 1 75  ? -12.67329 23.46795 -49.57782 1.000 38.57249 ? 75  LEU   A CD1 1 
ATOM   583  C CD2 . LEU   A 1 75  ? -11.45058 21.56604 -48.62246 1.000 33.08446 ? 75  LEU   A CD2 1 
ATOM   584  N N   . ARG   A 1 76  ? -15.52556 19.73519 -52.37273 1.000 34.00044 ? 76  ARG   A N   1 
ATOM   585  C CA  . ARG   A 1 76  ? -16.32488 18.56453 -52.69963 1.000 30.99829 ? 76  ARG   A CA  1 
ATOM   586  C C   . ARG   A 1 76  ? -15.70841 17.30816 -52.09285 1.000 28.56970 ? 76  ARG   A C   1 
ATOM   587  O O   . ARG   A 1 76  ? -14.54679 16.98105 -52.36099 1.000 30.77666 ? 76  ARG   A O   1 
ATOM   588  C CB  . ARG   A 1 76  ? -16.44228 18.43703 -54.21316 1.000 33.42371 ? 76  ARG   A CB  1 
ATOM   589  C CG  . ARG   A 1 76  ? -17.36231 17.34419 -54.65954 1.000 31.98862 ? 76  ARG   A CG  1 
ATOM   590  C CD  . ARG   A 1 76  ? -17.60188 17.48613 -56.14412 1.000 31.67811 ? 76  ARG   A CD  1 
ATOM   591  N NE  . ARG   A 1 76  ? -18.51146 16.45610 -56.60901 1.000 41.49886 ? 76  ARG   A NE  1 
ATOM   592  C CZ  . ARG   A 1 76  ? -19.83254 16.50249 -56.50587 1.000 40.41983 ? 76  ARG   A CZ  1 
ATOM   593  N NH1 . ARG   A 1 76  ? -20.45624 17.58538 -56.06746 1.000 37.36472 ? 76  ARG   A NH1 1 
ATOM   594  N NH2 . ARG   A 1 76  ? -20.54587 15.44336 -56.88116 1.000 32.95947 ? 76  ARG   A NH2 1 
ATOM   595  N N   . VAL   A 1 77  ? -16.48961 16.61520 -51.27565 1.000 27.65133 ? 77  VAL   A N   1 
ATOM   596  C CA  . VAL   A 1 77  ? -16.08505 15.36070 -50.65375 1.000 28.26262 ? 77  VAL   A CA  1 
ATOM   597  C C   . VAL   A 1 77  ? -16.26486 14.23295 -51.65848 1.000 32.24543 ? 77  VAL   A C   1 
ATOM   598  O O   . VAL   A 1 77  ? -17.35409 14.06587 -52.21815 1.000 30.60451 ? 77  VAL   A O   1 
ATOM   599  C CB  . VAL   A 1 77  ? -16.91665 15.10021 -49.38640 1.000 29.69948 ? 77  VAL   A CB  1 
ATOM   600  C CG1 . VAL   A 1 77  ? -16.66274 13.71175 -48.82715 1.000 27.92831 ? 77  VAL   A CG1 1 
ATOM   601  C CG2 . VAL   A 1 77  ? -16.62185 16.15102 -48.30959 1.000 28.62111 ? 77  VAL   A CG2 1 
ATOM   602  N N   . ILE   A 1 78  ? -15.21577 13.42877 -51.85918 1.000 29.40473 ? 78  ILE   A N   1 
ATOM   603  C CA  . ILE   A 1 78  ? -15.26382 12.32118 -52.80793 1.000 30.23562 ? 78  ILE   A CA  1 
ATOM   604  C C   . ILE   A 1 78  ? -15.00584 10.96980 -52.14282 1.000 33.50491 ? 78  ILE   A C   1 
ATOM   605  O O   . ILE   A 1 78  ? -14.81912 9.97095  -52.83086 1.000 29.90102 ? 78  ILE   A O   1 
ATOM   606  C CB  . ILE   A 1 78  ? -14.27986 12.54544 -53.96925 1.000 30.62699 ? 78  ILE   A CB  1 
ATOM   607  C CG1 . ILE   A 1 78  ? -12.84234 12.60334 -53.44366 1.000 33.20995 ? 78  ILE   A CG1 1 
ATOM   608  C CG2 . ILE   A 1 78  ? -14.65028 13.82928 -54.70793 1.000 30.24403 ? 78  ILE   A CG2 1 
ATOM   609  C CD1 . ILE   A 1 78  ? -11.78991 12.86826 -54.51362 1.000 34.32602 ? 78  ILE   A CD1 1 
ATOM   610  N N   . GLY   A 1 79  ? -14.98151 10.91642 -50.82398 1.000 29.68508 ? 79  GLY   A N   1 
ATOM   611  C CA  . GLY   A 1 79  ? -14.78256 9.65489  -50.12225 1.000 26.81501 ? 79  GLY   A CA  1 
ATOM   612  C C   . GLY   A 1 79  ? -14.83842 9.92868  -48.63675 1.000 33.77516 ? 79  GLY   A C   1 
ATOM   613  O O   . GLY   A 1 79  ? -14.64924 11.06767 -48.19297 1.000 29.79209 ? 79  GLY   A O   1 
ATOM   614  N N   . HIS   A 1 80  ? -15.12782 8.87088  -47.87502 1.000 30.33580 ? 80  HIS   A N   1 
ATOM   615  C CA  . HIS   A 1 80  ? -15.19360 9.04129  -46.42636 1.000 32.10450 ? 80  HIS   A CA  1 
ATOM   616  C C   . HIS   A 1 80  ? -14.95106 7.70671  -45.73072 1.000 33.73309 ? 80  HIS   A C   1 
ATOM   617  O O   . HIS   A 1 80  ? -15.26335 6.64394  -46.27357 1.000 33.04965 ? 80  HIS   A O   1 
ATOM   618  C CB  . HIS   A 1 80  ? -16.53512 9.66073  -45.98511 1.000 28.88221 ? 80  HIS   A CB  1 
ATOM   619  C CG  . HIS   A 1 80  ? -17.73343 8.78482  -46.20824 1.000 35.06345 ? 80  HIS   A CG  1 
ATOM   620  N ND1 . HIS   A 1 80  ? -18.36166 8.67185  -47.42916 1.000 36.94585 ? 80  HIS   A ND1 1 
ATOM   621  C CD2 . HIS   A 1 80  ? -18.40854 7.96609  -45.36416 1.000 34.89602 ? 80  HIS   A CD2 1 
ATOM   622  C CE1 . HIS   A 1 80  ? -19.38743 7.84584  -47.32222 1.000 38.13167 ? 80  HIS   A CE1 1 
ATOM   623  N NE2 . HIS   A 1 80  ? -19.43622 7.40104  -46.08020 1.000 39.28951 ? 80  HIS   A NE2 1 
ATOM   624  N N   . SER   A 1 81  ? -14.35584 7.76828  -44.53826 1.000 28.88309 ? 81  SER   A N   1 
ATOM   625  C CA  . SER   A 1 81  ? -14.13617 6.57201  -43.73134 1.000 28.95680 ? 81  SER   A CA  1 
ATOM   626  C C   . SER   A 1 81  ? -13.83716 6.99388  -42.29698 1.000 32.21856 ? 81  SER   A C   1 
ATOM   627  O O   . SER   A 1 81  ? -13.44385 8.13132  -42.03586 1.000 30.60918 ? 81  SER   A O   1 
ATOM   628  C CB  . SER   A 1 81  ? -12.97960 5.72079  -44.27188 1.000 34.83051 ? 81  SER   A CB  1 
ATOM   629  O OG  . SER   A 1 81  ? -11.74256 6.41484  -44.17391 1.000 33.98223 ? 81  SER   A OG  1 
ATOM   630  N N   . MET   A 1 82  ? -13.99747 6.05440  -41.37585 1.000 28.57386 ? 82  MET   A N   1 
ATOM   631  C CA  . MET   A 1 82  ? -13.81352 6.30958  -39.95701 1.000 29.52271 ? 82  MET   A CA  1 
ATOM   632  C C   . MET   A 1 82  ? -12.60211 5.53323  -39.46851 1.000 33.82149 ? 82  MET   A C   1 
ATOM   633  O O   . MET   A 1 82  ? -12.47305 4.34182  -39.75861 1.000 30.75093 ? 82  MET   A O   1 
ATOM   634  C CB  . MET   A 1 82  ? -15.04787 5.88856  -39.16499 1.000 32.68416 ? 82  MET   A CB  1 
ATOM   635  C CG  . MET   A 1 82  ? -14.94668 6.18109  -37.68714 1.000 33.27088 ? 82  MET   A CG  1 
ATOM   636  S SD  . MET   A 1 82  ? -16.49940 5.80314  -36.83981 1.000 39.09634 ? 82  MET   A SD  1 
ATOM   637  C CE  . MET   A 1 82  ? -17.16362 4.46739  -37.83593 1.000 37.45526 ? 82  MET   A CE  1 
ATOM   638  N N   . GLN   A 1 83  ? -11.72587 6.20429  -38.72581 1.000 24.95939 ? 83  GLN   A N   1 
ATOM   639  C CA  . GLN   A 1 83  ? -10.52728 5.59768  -38.14617 1.000 23.22512 ? 83  GLN   A CA  1 
ATOM   640  C C   . GLN   A 1 83  ? -10.59251 5.83474  -36.64698 1.000 29.65471 ? 83  GLN   A C   1 
ATOM   641  O O   . GLN   A 1 83  ? -10.34101 6.95464  -36.19494 1.000 25.28971 ? 83  GLN   A O   1 
ATOM   642  C CB  . GLN   A 1 83  ? -9.25496  6.19178  -38.73120 1.000 25.20818 ? 83  GLN   A CB  1 
ATOM   643  C CG  . GLN   A 1 83  ? -8.02374  5.53221  -38.13561 1.000 27.28315 ? 83  GLN   A CG  1 
ATOM   644  C CD  . GLN   A 1 83  ? -6.71217  6.04124  -38.69545 1.000 29.82420 ? 83  GLN   A CD  1 
ATOM   645  O OE1 . GLN   A 1 83  ? -6.66457  7.00110  -39.46808 1.000 29.76229 ? 83  GLN   A OE1 1 
ATOM   646  N NE2 . GLN   A 1 83  ? -5.63153  5.38703  -38.30762 1.000 28.70954 ? 83  GLN   A NE2 1 
ATOM   647  N N   . ASN   A 1 84  ? -10.94255 4.79824  -35.87732 1.000 28.96625 ? 84  ASN   A N   1 
ATOM   648  C CA  . ASN   A 1 84  ? -11.15392 4.97846  -34.43947 1.000 29.47156 ? 84  ASN   A CA  1 
ATOM   649  C C   . ASN   A 1 84  ? -12.12878 6.14171  -34.21015 1.000 28.82863 ? 84  ASN   A C   1 
ATOM   650  O O   . ASN   A 1 84  ? -13.24978 6.10383  -34.72353 1.000 26.43254 ? 84  ASN   A O   1 
ATOM   651  C CB  . ASN   A 1 84  ? -9.79859  5.16632  -33.73074 1.000 29.42755 ? 84  ASN   A CB  1 
ATOM   652  C CG  . ASN   A 1 84  ? -8.86818  3.95698  -33.93566 1.000 32.37143 ? 84  ASN   A CG  1 
ATOM   653  O OD1 . ASN   A 1 84  ? -9.24636  2.81885  -33.63552 1.000 30.86163 ? 84  ASN   A OD1 1 
ATOM   654  N ND2 . ASN   A 1 84  ? -7.66765  4.19800  -34.46206 1.000 30.19857 ? 84  ASN   A ND2 1 
ATOM   655  N N   . CYS   A 1 85  ? -11.73637 7.20660  -33.50200 1.000 25.32993 ? 85  CYS   A N   1 
ATOM   656  C CA  . CYS   A 1 85  ? -12.69620 8.26113  -33.17105 1.000 23.36563 ? 85  CYS   A CA  1 
ATOM   657  C C   . CYS   A 1 85  ? -12.65919 9.44727  -34.13044 1.000 28.19379 ? 85  CYS   A C   1 
ATOM   658  O O   . CYS   A 1 85  ? -13.30127 10.47282 -33.85796 1.000 24.20228 ? 85  CYS   A O   1 
ATOM   659  C CB  . CYS   A 1 85  ? -12.47629 8.76021  -31.74078 1.000 25.40950 ? 85  CYS   A CB  1 
ATOM   660  S SG  . CYS   A 1 85  ? -12.91012 7.57491  -30.46464 1.000 26.64192 ? 85  CYS   A SG  1 
ATOM   661  N N   . VAL   A 1 86  ? -11.94475 9.34621  -35.24800 1.000 20.94742 ? 86  VAL   A N   1 
ATOM   662  C CA  . VAL   A 1 86  ? -11.89764 10.46514 -36.17568 1.000 21.84978 ? 86  VAL   A CA  1 
ATOM   663  C C   . VAL   A 1 86  ? -12.48917 10.03243 -37.50199 1.000 29.21810 ? 86  VAL   A C   1 
ATOM   664  O O   . VAL   A 1 86  ? -12.50603 8.84878  -37.85320 1.000 28.45708 ? 86  VAL   A O   1 
ATOM   665  C CB  . VAL   A 1 86  ? -10.47962 11.04208 -36.38211 1.000 26.83879 ? 86  VAL   A CB  1 
ATOM   666  C CG1 . VAL   A 1 86  ? -9.98718  11.73139 -35.08011 1.000 23.79812 ? 86  VAL   A CG1 1 
ATOM   667  C CG2 . VAL   A 1 86  ? -9.53767  10.00102 -36.82680 1.000 29.19560 ? 86  VAL   A CG2 1 
ATOM   668  N N   . LEU   A 1 87  ? -12.97935 11.02282 -38.24114 1.000 27.32444 ? 87  LEU   A N   1 
ATOM   669  C CA  . LEU   A 1 87  ? -13.47177 10.83549 -39.59332 1.000 25.51677 ? 87  LEU   A CA  1 
ATOM   670  C C   . LEU   A 1 87  ? -12.41358 11.33065 -40.56136 1.000 32.61996 ? 87  LEU   A C   1 
ATOM   671  O O   . LEU   A 1 87  ? -11.75784 12.34642 -40.30037 1.000 24.10797 ? 87  LEU   A O   1 
ATOM   672  C CB  . LEU   A 1 87  ? -14.73417 11.65839 -39.81912 1.000 28.55617 ? 87  LEU   A CB  1 
ATOM   673  C CG  . LEU   A 1 87  ? -16.04289 10.99936 -39.43998 1.000 35.06913 ? 87  LEU   A CG  1 
ATOM   674  C CD1 . LEU   A 1 87  ? -17.19586 11.80675 -40.06767 1.000 32.66161 ? 87  LEU   A CD1 1 
ATOM   675  C CD2 . LEU   A 1 87  ? -16.06549 9.49899  -39.77240 1.000 38.65794 ? 87  LEU   A CD2 1 
ATOM   676  N N   . LYS   A 1 88  ? -12.28007 10.64384 -41.69896 1.000 29.65373 ? 88  LYS   A N   1 
ATOM   677  C CA  . LYS   A 1 88  ? -11.42499 11.09635 -42.78930 1.000 29.03158 ? 88  LYS   A CA  1 
ATOM   678  C C   . LYS   A 1 88  ? -12.30164 11.29377 -44.01934 1.000 27.93233 ? 88  LYS   A C   1 
ATOM   679  O O   . LYS   A 1 88  ? -12.91596 10.33394 -44.50443 1.000 30.42473 ? 88  LYS   A O   1 
ATOM   680  C CB  . LYS   A 1 88  ? -10.30255 10.08584 -43.06408 1.000 27.27400 ? 88  LYS   A CB  1 
ATOM   681  C CG  . LYS   A 1 88  ? -9.32440  9.95709  -41.89154 1.000 32.38901 ? 88  LYS   A CG  1 
ATOM   682  C CD  . LYS   A 1 88  ? -8.06846  9.16838  -42.23817 1.000 33.93665 ? 88  LYS   A CD  1 
ATOM   683  C CE  . LYS   A 1 88  ? -8.23697  7.65968  -42.12062 1.000 34.73601 ? 88  LYS   A CE  1 
ATOM   684  N NZ  . LYS   A 1 88  ? -6.90498  6.97413  -42.29269 1.000 35.28690 ? 88  LYS   A NZ  1 
ATOM   685  N N   . LEU   A 1 89  ? -12.39239 12.53546 -44.49349 1.000 24.65367 ? 89  LEU   A N   1 
ATOM   686  C CA  . LEU   A 1 89  ? -13.12154 12.87836 -45.70512 1.000 26.39204 ? 89  LEU   A CA  1 
ATOM   687  C C   . LEU   A 1 89  ? -12.11634 13.15317 -46.81170 1.000 26.21298 ? 89  LEU   A C   1 
ATOM   688  O O   . LEU   A 1 89  ? -11.32242 14.08855 -46.70361 1.000 24.89753 ? 89  LEU   A O   1 
ATOM   689  C CB  . LEU   A 1 89  ? -14.00541 14.10737 -45.48247 1.000 22.42830 ? 89  LEU   A CB  1 
ATOM   690  C CG  . LEU   A 1 89  ? -14.84315 14.01923 -44.20196 1.000 23.70400 ? 89  LEU   A CG  1 
ATOM   691  C CD1 . LEU   A 1 89  ? -15.70410 15.28148 -44.03299 1.000 21.56746 ? 89  LEU   A CD1 1 
ATOM   692  C CD2 . LEU   A 1 89  ? -15.69518 12.73569 -44.17570 1.000 27.55049 ? 89  LEU   A CD2 1 
ATOM   693  N N   . LYS   A 1 90  ? -12.14028 12.34796 -47.87229 1.000 27.14261 ? 90  LYS   A N   1 
ATOM   694  C CA  . LYS   A 1 90  ? -11.34803 12.68312 -49.04407 1.000 24.94482 ? 90  LYS   A CA  1 
ATOM   695  C C   . LYS   A 1 90  ? -12.05231 13.79001 -49.82151 1.000 30.12298 ? 90  LYS   A C   1 
ATOM   696  O O   . LYS   A 1 90  ? -13.27884 13.77230 -49.97995 1.000 29.79398 ? 90  LYS   A O   1 
ATOM   697  C CB  . LYS   A 1 90  ? -11.12237 11.45424 -49.93265 1.000 27.17554 ? 90  LYS   A CB  1 
ATOM   698  C CG  . LYS   A 1 90  ? -10.15058 11.70290 -51.08062 1.000 32.65957 ? 90  LYS   A CG  1 
ATOM   699  C CD  . LYS   A 1 90  ? -9.47519  10.40408 -51.53919 1.000 36.61259 ? 90  LYS   A CD  1 
ATOM   700  C CE  . LYS   A 1 90  ? -8.34212  10.66919 -52.50289 1.000 46.43198 ? 90  LYS   A CE  1 
ATOM   701  N NZ  . LYS   A 1 90  ? -8.48177  9.83156  -53.73627 1.000 53.59955 ? 90  LYS   A NZ  1 
ATOM   702  N N   . VAL   A 1 91  ? -11.27567 14.77408 -50.28501 1.000 24.95231 ? 91  VAL   A N   1 
ATOM   703  C CA  . VAL   A 1 91  ? -11.81828 15.89551 -51.04151 1.000 28.71772 ? 91  VAL   A CA  1 
ATOM   704  C C   . VAL   A 1 91  ? -11.09551 15.96381 -52.38545 1.000 29.68682 ? 91  VAL   A C   1 
ATOM   705  O O   . VAL   A 1 91  ? -10.00261 15.41944 -52.54613 1.000 27.83749 ? 91  VAL   A O   1 
ATOM   706  C CB  . VAL   A 1 91  ? -11.69627 17.22914 -50.26884 1.000 28.37529 ? 91  VAL   A CB  1 
ATOM   707  C CG1 . VAL   A 1 91  ? -12.61754 17.21240 -49.05782 1.000 28.44939 ? 91  VAL   A CG1 1 
ATOM   708  C CG2 . VAL   A 1 91  ? -10.23367 17.46594 -49.80193 1.000 25.17631 ? 91  VAL   A CG2 1 
ATOM   709  N N   . ASP   A 1 92  ? -11.71427 16.64896 -53.35677 1.000 28.77211 ? 92  ASP   A N   1 
ATOM   710  C CA  . ASP   A 1 92  ? -11.13976 16.67388 -54.70540 1.000 35.18469 ? 92  ASP   A CA  1 
ATOM   711  C C   . ASP   A 1 92  ? -10.06773 17.74245 -54.88839 1.000 38.08866 ? 92  ASP   A C   1 
ATOM   712  O O   . ASP   A 1 92  ? -9.56483  17.90822 -56.00947 1.000 34.54443 ? 92  ASP   A O   1 
ATOM   713  C CB  . ASP   A 1 92  ? -12.22862 16.87282 -55.77783 1.000 39.96409 ? 92  ASP   A CB  1 
ATOM   714  C CG  . ASP   A 1 92  ? -13.00640 18.20334 -55.64328 1.000 42.22460 ? 92  ASP   A CG  1 
ATOM   715  O OD1 . ASP   A 1 92  ? -12.64658 19.09520 -54.83697 1.000 44.47374 ? 92  ASP   A OD1 1 
ATOM   716  O OD2 . ASP   A 1 92  ? -14.00329 18.35984 -56.38658 1.000 47.07999 ? 92  ASP   A OD2 1 
ATOM   717  N N   . THR   A 1 93  ? -9.70528  18.46940 -53.83079 1.000 30.67432 ? 93  THR   A N   1 
ATOM   718  C CA  . THR   A 1 93  ? -8.73056  19.55072 -53.91021 1.000 30.73420 ? 93  THR   A CA  1 
ATOM   719  C C   . THR   A 1 93  ? -7.68110  19.31480 -52.83185 1.000 29.80778 ? 93  THR   A C   1 
ATOM   720  O O   . THR   A 1 93  ? -8.03262  19.12379 -51.66403 1.000 27.48765 ? 93  THR   A O   1 
ATOM   721  C CB  . THR   A 1 93  ? -9.39069  20.91437 -53.68958 1.000 30.35184 ? 93  THR   A CB  1 
ATOM   722  O OG1 . THR   A 1 93  ? -10.41760 21.11653 -54.67280 1.000 35.52418 ? 93  THR   A OG1 1 
ATOM   723  C CG2 . THR   A 1 93  ? -8.35433  22.02125 -53.83162 1.000 29.70059 ? 93  THR   A CG2 1 
ATOM   724  N N   . ALA   A 1 94  ? -6.40915  19.29883 -53.21081 1.000 26.39326 ? 94  ALA   A N   1 
ATOM   725  C CA  . ALA   A 1 94  ? -5.35459  19.24696 -52.19741 1.000 30.54752 ? 94  ALA   A CA  1 
ATOM   726  C C   . ALA   A 1 94  ? -5.14619  20.63780 -51.61195 1.000 28.52429 ? 94  ALA   A C   1 
ATOM   727  O O   . ALA   A 1 94  ? -5.22290  21.64551 -52.32665 1.000 24.45723 ? 94  ALA   A O   1 
ATOM   728  C CB  . ALA   A 1 94  ? -4.04702  18.72030 -52.78622 1.000 27.48691 ? 94  ALA   A CB  1 
ATOM   729  N N   . ASN   A 1 95  ? -4.91623  20.69479 -50.29935 1.000 29.16718 ? 95  ASN   A N   1 
ATOM   730  C CA  . ASN   A 1 95  ? -4.67999  21.97027 -49.63762 1.000 25.58965 ? 95  ASN   A CA  1 
ATOM   731  C C   . ASN   A 1 95  ? -3.35935  22.56129 -50.11269 1.000 22.55089 ? 95  ASN   A C   1 
ATOM   732  O O   . ASN   A 1 95  ? -2.30260  21.98463 -49.81662 1.000 27.68387 ? 95  ASN   A O   1 
ATOM   733  C CB  . ASN   A 1 95  ? -4.65934  21.79772 -48.11137 1.000 26.65214 ? 95  ASN   A CB  1 
ATOM   734  C CG  . ASN   A 1 95  ? -4.42372  23.12853 -47.37517 1.000 28.40757 ? 95  ASN   A CG  1 
ATOM   735  O OD1 . ASN   A 1 95  ? -4.34927  24.18744 -47.99492 1.000 27.35562 ? 95  ASN   A OD1 1 
ATOM   736  N ND2 . ASN   A 1 95  ? -4.34292  23.07059 -46.04064 1.000 28.73317 ? 95  ASN   A ND2 1 
ATOM   737  N N   . PRO   A 1 96  ? -3.36528  23.69815 -50.82307 1.000 25.94113 ? 96  PRO   A N   1 
ATOM   738  C CA  . PRO   A 1 96  ? -2.10414  24.27787 -51.31667 1.000 28.71837 ? 96  PRO   A CA  1 
ATOM   739  C C   . PRO   A 1 96  ? -1.22041  24.83654 -50.21670 1.000 31.22137 ? 96  PRO   A C   1 
ATOM   740  O O   . PRO   A 1 96  ? -0.07593  25.22636 -50.50133 1.000 31.44573 ? 96  PRO   A O   1 
ATOM   741  C CB  . PRO   A 1 96  ? -2.58046  25.39669 -52.25450 1.000 26.72222 ? 96  PRO   A CB  1 
ATOM   742  C CG  . PRO   A 1 96  ? -3.88898  25.80926 -51.67912 1.000 34.30985 ? 96  PRO   A CG  1 
ATOM   743  C CD  . PRO   A 1 96  ? -4.52638  24.53257 -51.18223 1.000 26.81768 ? 96  PRO   A CD  1 
ATOM   744  N N   . LYS   A 1 97  ? -1.70661  24.89075 -48.97760 1.000 28.08830 ? 97  LYS   A N   1 
ATOM   745  C CA  . LYS   A 1 97  ? -0.92737  25.40080 -47.85511 1.000 25.82314 ? 97  LYS   A CA  1 
ATOM   746  C C   . LYS   A 1 97  ? -0.49435  24.30738 -46.87808 1.000 29.12041 ? 97  LYS   A C   1 
ATOM   747  O O   . LYS   A 1 97  ? -0.04403  24.62812 -45.76644 1.000 27.67439 ? 97  LYS   A O   1 
ATOM   748  C CB  . LYS   A 1 97  ? -1.71248  26.49950 -47.12300 1.000 27.50573 ? 97  LYS   A CB  1 
ATOM   749  C CG  . LYS   A 1 97  ? -2.10503  27.67125 -48.01242 1.000 29.95725 ? 97  LYS   A CG  1 
ATOM   750  C CD  . LYS   A 1 97  ? -2.93470  28.69380 -47.25046 1.000 35.67659 ? 97  LYS   A CD  1 
ATOM   751  C CE  . LYS   A 1 97  ? -3.24925  29.90184 -48.12474 1.000 38.90576 ? 97  LYS   A CE  1 
ATOM   752  N NZ  . LYS   A 1 97  ? -3.88621  31.03025 -47.36696 1.000 43.38296 ? 97  LYS   A NZ  1 
ATOM   753  N N   . THR   A 1 98  ? -0.59556  23.03754 -47.26383 1.000 28.72518 ? 98  THR   A N   1 
ATOM   754  C CA  . THR   A 1 98  ? -0.16865  21.93277 -46.39925 1.000 28.50383 ? 98  THR   A CA  1 
ATOM   755  C C   . THR   A 1 98  ? 1.27947   22.13615 -45.96899 1.000 32.05847 ? 98  THR   A C   1 
ATOM   756  O O   . THR   A 1 98  ? 2.15873   22.24661 -46.83510 1.000 27.50310 ? 98  THR   A O   1 
ATOM   757  C CB  . THR   A 1 98  ? -0.29669  20.58717 -47.11587 1.000 28.09742 ? 98  THR   A CB  1 
ATOM   758  O OG1 . THR   A 1 98  ? -1.62363  20.42397 -47.61615 1.000 27.43414 ? 98  THR   A OG1 1 
ATOM   759  C CG2 . THR   A 1 98  ? 0.01774   19.43067 -46.16560 1.000 27.73946 ? 98  THR   A CG2 1 
ATOM   760  N N   . PRO   A 1 99  ? 1.57751   22.20001 -44.67428 1.000 28.91865 ? 99  PRO   A N   1 
ATOM   761  C CA  . PRO   A 1 99  ? 2.97689   22.22849 -44.24316 1.000 29.30164 ? 99  PRO   A CA  1 
ATOM   762  C C   . PRO   A 1 99  ? 3.56170   20.82331 -44.26332 1.000 26.15926 ? 99  PRO   A C   1 
ATOM   763  O O   . PRO   A 1 99  ? 2.84781   19.82680 -44.37087 1.000 27.30030 ? 99  PRO   A O   1 
ATOM   764  C CB  . PRO   A 1 99  ? 2.89134   22.76020 -42.80385 1.000 29.28276 ? 99  PRO   A CB  1 
ATOM   765  C CG  . PRO   A 1 99  ? 1.60747   22.21751 -42.31839 1.000 24.53757 ? 99  PRO   A CG  1 
ATOM   766  C CD  . PRO   A 1 99  ? 0.66158   22.17753 -43.51678 1.000 26.24516 ? 99  PRO   A CD  1 
ATOM   767  N N   . LYS   A 1 100 ? 4.88739   20.75411 -44.13761 1.000 26.65703 ? 100 LYS   A N   1 
ATOM   768  C CA  . LYS   A 1 100 ? 5.51955   19.47525 -43.82346 1.000 26.73610 ? 100 LYS   A CA  1 
ATOM   769  C C   . LYS   A 1 100 ? 5.01501   19.03483 -42.45477 1.000 24.94761 ? 100 LYS   A C   1 
ATOM   770  O O   . LYS   A 1 100 ? 4.99569   19.83697 -41.51949 1.000 26.34342 ? 100 LYS   A O   1 
ATOM   771  C CB  . LYS   A 1 100 ? 7.04153   19.63216 -43.82695 1.000 29.60794 ? 100 LYS   A CB  1 
ATOM   772  C CG  . LYS   A 1 100 ? 7.86353   18.43913 -43.27214 1.000 31.08643 ? 100 LYS   A CG  1 
ATOM   773  C CD  . LYS   A 1 100 ? 9.34805   18.60760 -43.65395 1.000 38.01016 ? 100 LYS   A CD  1 
ATOM   774  C CE  . LYS   A 1 100 ? 10.28708  17.73210 -42.83719 1.000 44.10517 ? 100 LYS   A CE  1 
ATOM   775  N NZ  . LYS   A 1 100 ? 9.68110   16.42980 -42.45289 1.000 52.56122 ? 100 LYS   A NZ  1 
ATOM   776  N N   . TYR   A 1 101 ? 4.54972   17.79249 -42.33183 1.000 24.05983 ? 101 TYR   A N   1 
ATOM   777  C CA  . TYR   A 1 101 ? 3.89103   17.42438 -41.08342 1.000 25.29893 ? 101 TYR   A CA  1 
ATOM   778  C C   . TYR   A 1 101 ? 4.08947   15.95440 -40.75229 1.000 29.99824 ? 101 TYR   A C   1 
ATOM   779  O O   . TYR   A 1 101 ? 4.41844   15.13910 -41.61754 1.000 23.67483 ? 101 TYR   A O   1 
ATOM   780  C CB  . TYR   A 1 101 ? 2.38070   17.71794 -41.12196 1.000 25.62455 ? 101 TYR   A CB  1 
ATOM   781  C CG  . TYR   A 1 101 ? 1.57979   16.74600 -41.97945 1.000 26.91610 ? 101 TYR   A CG  1 
ATOM   782  C CD1 . TYR   A 1 101 ? 1.43176   16.95114 -43.34074 1.000 27.02211 ? 101 TYR   A CD1 1 
ATOM   783  C CD2 . TYR   A 1 101 ? 0.99344   15.62049 -41.42392 1.000 26.96056 ? 101 TYR   A CD2 1 
ATOM   784  C CE1 . TYR   A 1 101 ? 0.70133   16.07185 -44.12711 1.000 30.53303 ? 101 TYR   A CE1 1 
ATOM   785  C CE2 . TYR   A 1 101 ? 0.27954   14.72850 -42.20434 1.000 25.46406 ? 101 TYR   A CE2 1 
ATOM   786  C CZ  . TYR   A 1 101 ? 0.14414   14.95643 -43.55224 1.000 28.11354 ? 101 TYR   A CZ  1 
ATOM   787  O OH  . TYR   A 1 101 ? -0.58099  14.08232 -44.32825 1.000 33.58350 ? 101 TYR   A OH  1 
ATOM   788  N N   . LYS   A 1 102 ? 3.85652   15.63435 -39.47295 1.000 27.28671 ? 102 LYS   A N   1 
ATOM   789  C CA  . LYS   A 1 102 ? 3.78103   14.27390 -38.96475 1.000 21.55229 ? 102 LYS   A CA  1 
ATOM   790  C C   . LYS   A 1 102 ? 2.63801   14.16832 -37.96448 1.000 22.81979 ? 102 LYS   A C   1 
ATOM   791  O O   . LYS   A 1 102 ? 2.24449   15.15027 -37.33072 1.000 22.66523 ? 102 LYS   A O   1 
ATOM   792  C CB  . LYS   A 1 102 ? 5.05381   13.80990 -38.23565 1.000 29.03620 ? 102 LYS   A CB  1 
ATOM   793  C CG  . LYS   A 1 102 ? 6.38452   14.13193 -38.86804 1.000 37.85493 ? 102 LYS   A CG  1 
ATOM   794  C CD  . LYS   A 1 102 ? 7.50616   13.69984 -37.90733 1.000 40.27127 ? 102 LYS   A CD  1 
ATOM   795  C CE  . LYS   A 1 102 ? 8.77780   14.54184 -38.08705 1.000 50.85157 ? 102 LYS   A CE  1 
ATOM   796  N NZ  . LYS   A 1 102 ? 10.02117  13.85964 -37.60863 1.000 52.66188 ? 102 LYS   A NZ  1 
ATOM   797  N N   . PHE   A 1 103 ? 2.12334   12.95439 -37.80953 1.000 23.96179 ? 103 PHE   A N   1 
ATOM   798  C CA  . PHE   A 1 103 ? 1.21307   12.63223 -36.72114 1.000 23.87637 ? 103 PHE   A CA  1 
ATOM   799  C C   . PHE   A 1 103 ? 2.03757   11.93482 -35.64605 1.000 25.52264 ? 103 PHE   A C   1 
ATOM   800  O O   . PHE   A 1 103 ? 2.74272   10.96614 -35.94695 1.000 30.24565 ? 103 PHE   A O   1 
ATOM   801  C CB  . PHE   A 1 103 ? 0.08418   11.71280 -37.18925 1.000 25.78518 ? 103 PHE   A CB  1 
ATOM   802  C CG  . PHE   A 1 103 ? -0.95356  12.38377 -38.06541 1.000 25.09760 ? 103 PHE   A CG  1 
ATOM   803  C CD1 . PHE   A 1 103 ? -0.95919  13.76585 -38.26177 1.000 22.61259 ? 103 PHE   A CD1 1 
ATOM   804  C CD2 . PHE   A 1 103 ? -1.91734  11.60868 -38.70689 1.000 28.85585 ? 103 PHE   A CD2 1 
ATOM   805  C CE1 . PHE   A 1 103 ? -1.92624  14.37461 -39.07383 1.000 23.13396 ? 103 PHE   A CE1 1 
ATOM   806  C CE2 . PHE   A 1 103 ? -2.87807  12.19336 -39.51001 1.000 29.55507 ? 103 PHE   A CE2 1 
ATOM   807  C CZ  . PHE   A 1 103 ? -2.88168  13.59085 -39.69283 1.000 26.32727 ? 103 PHE   A CZ  1 
ATOM   808  N N   . VAL   A 1 104 ? 1.97207   12.43177 -34.40491 1.000 23.32572 ? 104 VAL   A N   1 
ATOM   809  C CA  . VAL   A 1 104 ? 2.69162   11.82510 -33.28429 1.000 22.60234 ? 104 VAL   A CA  1 
ATOM   810  C C   . VAL   A 1 104 ? 1.72818   11.63122 -32.11838 1.000 24.87992 ? 104 VAL   A C   1 
ATOM   811  O O   . VAL   A 1 104 ? 0.73539   12.35027 -31.97542 1.000 26.16973 ? 104 VAL   A O   1 
ATOM   812  C CB  . VAL   A 1 104 ? 3.91932   12.66417 -32.82913 1.000 26.53651 ? 104 VAL   A CB  1 
ATOM   813  C CG1 . VAL   A 1 104 ? 4.92235   12.87580 -33.98596 1.000 24.69049 ? 104 VAL   A CG1 1 
ATOM   814  C CG2 . VAL   A 1 104 ? 3.47284   13.99757 -32.25924 1.000 26.92647 ? 104 VAL   A CG2 1 
ATOM   815  N N   . ARG   A 1 105 ? 2.01689   10.65389 -31.27920 1.000 22.26709 ? 105 ARG   A N   1 
ATOM   816  C CA  . ARG   A 1 105 ? 1.28981   10.48068 -30.02955 1.000 25.71193 ? 105 ARG   A CA  1 
ATOM   817  C C   . ARG   A 1 105 ? 2.23687   10.86811 -28.89764 1.000 28.70378 ? 105 ARG   A C   1 
ATOM   818  O O   . ARG   A 1 105 ? 3.30093   10.26232 -28.73960 1.000 28.66202 ? 105 ARG   A O   1 
ATOM   819  C CB  . ARG   A 1 105 ? 0.77270   9.04472  -29.88604 1.000 28.27901 ? 105 ARG   A CB  1 
ATOM   820  C CG  . ARG   A 1 105 ? -0.07499  8.80099  -28.64155 1.000 25.88734 ? 105 ARG   A CG  1 
ATOM   821  C CD  . ARG   A 1 105 ? -0.72856  7.44065  -28.66660 1.000 24.71449 ? 105 ARG   A CD  1 
ATOM   822  N NE  . ARG   A 1 105 ? -1.48940  7.19366  -27.44849 1.000 22.68158 ? 105 ARG   A NE  1 
ATOM   823  C CZ  . ARG   A 1 105 ? -2.76283  7.52486  -27.30853 1.000 26.58011 ? 105 ARG   A CZ  1 
ATOM   824  N NH1 . ARG   A 1 105 ? -3.45021  8.06025  -28.31102 1.000 24.51385 ? 105 ARG   A NH1 1 
ATOM   825  N NH2 . ARG   A 1 105 ? -3.36504  7.30521  -26.14484 1.000 25.99442 ? 105 ARG   A NH2 1 
ATOM   826  N N   . ILE   A 1 106 ? 1.87268   11.89521 -28.13100 1.000 27.34231 ? 106 ILE   A N   1 
ATOM   827  C CA  . ILE   A 1 106 ? 2.77320   12.38926 -27.09886 1.000 25.43812 ? 106 ILE   A CA  1 
ATOM   828  C C   . ILE   A 1 106 ? 2.56421   11.59343 -25.81815 1.000 26.02567 ? 106 ILE   A C   1 
ATOM   829  O O   . ILE   A 1 106 ? 1.56017   10.89380 -25.62694 1.000 25.91284 ? 106 ILE   A O   1 
ATOM   830  C CB  . ILE   A 1 106 ? 2.62107   13.90540 -26.84002 1.000 27.98501 ? 106 ILE   A CB  1 
ATOM   831  C CG1 . ILE   A 1 106 ? 1.18425   14.25385 -26.47004 1.000 23.37863 ? 106 ILE   A CG1 1 
ATOM   832  C CG2 . ILE   A 1 106 ? 3.09240   14.72181 -28.03679 1.000 35.22329 ? 106 ILE   A CG2 1 
ATOM   833  C CD1 . ILE   A 1 106 ? 1.11477   15.60570 -25.81612 1.000 27.92878 ? 106 ILE   A CD1 1 
ATOM   834  N N   . GLN   A 1 107 ? 3.51162   11.68731 -24.96624 1.000 26.00408 ? 107 GLN   A N   1 
ATOM   835  C CA  . GLN   A 1 107 ? 3.62147   11.09624 -23.64982 1.000 27.56706 ? 107 GLN   A CA  1 
ATOM   836  C C   . GLN   A 1 107 ? 3.08244   12.07141 -22.61041 1.000 26.05526 ? 107 GLN   A C   1 
ATOM   837  O O   . GLN   A 1 107 ? 3.16714   13.29367 -22.80258 1.000 27.03861 ? 107 GLN   A O   1 
ATOM   838  C CB  . GLN   A 1 107 ? 5.08804   10.78606 -23.33940 1.000 31.94969 ? 107 GLN   A CB  1 
ATOM   839  C CG  . GLN   A 1 107 ? 5.70000   9.75037  -24.27395 1.000 36.61419 ? 107 GLN   A CG  1 
ATOM   840  C CD  . GLN   A 1 107 ? 5.17357   8.36747  -23.99316 1.000 44.02840 ? 107 GLN   A CD  1 
ATOM   841  O OE1 . GLN   A 1 107 ? 4.88131   8.02594  -22.84401 1.000 44.34978 ? 107 GLN   A OE1 1 
ATOM   842  N NE2 . GLN   A 1 107 ? 5.02319   7.56509  -25.04353 1.000 44.18362 ? 107 GLN   A NE2 1 
ATOM   843  N N   . PRO   A 1 108 ? 2.54887   11.55739 -21.50117 1.000 25.93000 ? 108 PRO   A N   1 
ATOM   844  C CA  . PRO   A 1 108 ? 2.21276   12.43187 -20.36923 1.000 24.07601 ? 108 PRO   A CA  1 
ATOM   845  C C   . PRO   A 1 108 ? 3.42226   13.24234 -19.95615 1.000 26.67823 ? 108 PRO   A C   1 
ATOM   846  O O   . PRO   A 1 108 ? 4.54842   12.74232 -19.95043 1.000 23.79990 ? 108 PRO   A O   1 
ATOM   847  C CB  . PRO   A 1 108 ? 1.80308   11.45290 -19.25954 1.000 26.89951 ? 108 PRO   A CB  1 
ATOM   848  C CG  . PRO   A 1 108 ? 1.60315   10.14069 -19.93240 1.000 34.17063 ? 108 PRO   A CG  1 
ATOM   849  C CD  . PRO   A 1 108 ? 2.41802   10.12826 -21.16462 1.000 32.03099 ? 108 PRO   A CD  1 
ATOM   850  N N   . GLY   A 1 109 ? 3.18765   14.50483 -19.62357 1.000 23.97162 ? 109 GLY   A N   1 
ATOM   851  C CA  . GLY   A 1 109 ? 4.24604   15.39317 -19.22937 1.000 22.26938 ? 109 GLY   A CA  1 
ATOM   852  C C   . GLY   A 1 109 ? 4.75348   16.28135 -20.33648 1.000 26.65439 ? 109 GLY   A C   1 
ATOM   853  O O   . GLY   A 1 109 ? 5.39136   17.29679 -20.04243 1.000 26.31289 ? 109 GLY   A O   1 
ATOM   854  N N   . GLN   A 1 110 ? 4.49021   15.92546 -21.60006 1.000 18.58313 ? 110 GLN   A N   1 
ATOM   855  C CA  . GLN   A 1 110 ? 4.85470   16.75741 -22.73502 1.000 24.03820 ? 110 GLN   A CA  1 
ATOM   856  C C   . GLN   A 1 110 ? 3.83350   17.86520 -22.93881 1.000 20.81252 ? 110 GLN   A C   1 
ATOM   857  O O   . GLN   A 1 110 ? 2.66761   17.74116 -22.56406 1.000 19.77464 ? 110 GLN   A O   1 
ATOM   858  C CB  . GLN   A 1 110 ? 4.94589   15.92795 -24.02132 1.000 21.34882 ? 110 GLN   A CB  1 
ATOM   859  C CG  . GLN   A 1 110 ? 5.63147   14.61706 -23.82739 1.000 32.15260 ? 110 GLN   A CG  1 
ATOM   860  C CD  . GLN   A 1 110 ? 7.08304   14.71797 -24.13722 1.000 39.38790 ? 110 GLN   A CD  1 
ATOM   861  O OE1 . GLN   A 1 110 ? 7.87607   15.18315 -23.31074 1.000 43.31535 ? 110 GLN   A OE1 1 
ATOM   862  N NE2 . GLN   A 1 110 ? 7.45985   14.28638 -25.34270 1.000 48.59912 ? 110 GLN   A NE2 1 
ATOM   863  N N   . THR   A 1 111 ? 4.27407   18.92655 -23.60662 1.000 16.43073 ? 111 THR   A N   1 
ATOM   864  C CA  . THR   A 1 111 ? 3.42933   20.08502 -23.87956 1.000 22.89146 ? 111 THR   A CA  1 
ATOM   865  C C   . THR   A 1 111 ? 3.17459   20.23671 -25.37738 1.000 19.85484 ? 111 THR   A C   1 
ATOM   866  O O   . THR   A 1 111 ? 3.90366   19.68184 -26.21601 1.000 23.59430 ? 111 THR   A O   1 
ATOM   867  C CB  . THR   A 1 111 ? 4.06612   21.38127 -23.34388 1.000 21.77310 ? 111 THR   A CB  1 
ATOM   868  O OG1 . THR   A 1 111 ? 5.35428   21.54941 -23.94144 1.000 20.48398 ? 111 THR   A OG1 1 
ATOM   869  C CG2 . THR   A 1 111 ? 4.21312   21.29091 -21.81410 1.000 24.03587 ? 111 THR   A CG2 1 
ATOM   870  N N   . PHE   A 1 112 ? 2.16951   21.04928 -25.70481 1.000 21.37266 ? 112 PHE   A N   1 
ATOM   871  C CA  . PHE   A 1 112 ? 1.89720   21.42272 -27.09137 1.000 22.58673 ? 112 PHE   A CA  1 
ATOM   872  C C   . PHE   A 1 112 ? 1.06530   22.71125 -27.12202 1.000 20.69969 ? 112 PHE   A C   1 
ATOM   873  O O   . PHE   A 1 112 ? 0.47911   23.12577 -26.11846 1.000 22.65456 ? 112 PHE   A O   1 
ATOM   874  C CB  . PHE   A 1 112 ? 1.18609   20.27895 -27.84180 1.000 19.93794 ? 112 PHE   A CB  1 
ATOM   875  C CG  . PHE   A 1 112 ? -0.05307  19.76804 -27.14295 1.000 20.40585 ? 112 PHE   A CG  1 
ATOM   876  C CD1 . PHE   A 1 112 ? 0.04037   18.76874 -26.18841 1.000 19.44839 ? 112 PHE   A CD1 1 
ATOM   877  C CD2 . PHE   A 1 112 ? -1.31223  20.29043 -27.43515 1.000 20.09993 ? 112 PHE   A CD2 1 
ATOM   878  C CE1 . PHE   A 1 112 ? -1.11037  18.29145 -25.51535 1.000 21.37990 ? 112 PHE   A CE1 1 
ATOM   879  C CE2 . PHE   A 1 112 ? -2.45273  19.82432 -26.77584 1.000 20.95745 ? 112 PHE   A CE2 1 
ATOM   880  C CZ  . PHE   A 1 112 ? -2.34595  18.80092 -25.81942 1.000 21.70505 ? 112 PHE   A CZ  1 
ATOM   881  N N   . SER   A 1 113 ? 0.99809   23.33639 -28.30316 1.000 19.74650 ? 113 SER   A N   1 
ATOM   882  C CA  . SER   A 1 113 ? 0.13444   24.49961 -28.50088 1.000 16.50848 ? 113 SER   A CA  1 
ATOM   883  C C   . SER   A 1 113 ? -1.22107  24.06713 -29.04609 1.000 21.59263 ? 113 SER   A C   1 
ATOM   884  O O   . SER   A 1 113 ? -1.30448  23.18375 -29.90328 1.000 21.15097 ? 113 SER   A O   1 
ATOM   885  C CB  . SER   A 1 113 ? 0.77096   25.50386 -29.47524 1.000 19.61623 ? 113 SER   A CB  1 
ATOM   886  O OG  . SER   A 1 113 ? 2.02818   25.95053 -29.00719 1.000 22.19677 ? 113 SER   A OG  1 
ATOM   887  N N   . VAL   A 1 114 ? -2.28106  24.71093 -28.56527 1.000 19.49678 ? 114 VAL   A N   1 
ATOM   888  C CA  . VAL   A 1 114 ? -3.62758  24.52177 -29.08642 1.000 17.56187 ? 114 VAL   A CA  1 
ATOM   889  C C   . VAL   A 1 114 ? -4.00146  25.76245 -29.87345 1.000 18.22964 ? 114 VAL   A C   1 
ATOM   890  O O   . VAL   A 1 114 ? -3.85021  26.88843 -29.37288 1.000 20.42234 ? 114 VAL   A O   1 
ATOM   891  C CB  . VAL   A 1 114 ? -4.64680  24.27326 -27.95513 1.000 20.01426 ? 114 VAL   A CB  1 
ATOM   892  C CG1 . VAL   A 1 114 ? -6.07163  24.21953 -28.51715 1.000 21.21844 ? 114 VAL   A CG1 1 
ATOM   893  C CG2 . VAL   A 1 114 ? -4.28129  22.98622 -27.20045 1.000 22.43565 ? 114 VAL   A CG2 1 
ATOM   894  N N   . LEU   A 1 115 ? -4.47047  25.55407 -31.11175 1.000 19.90478 ? 115 LEU   A N   1 
ATOM   895  C CA  . LEU   A 1 115 ? -5.17274  26.56471 -31.89813 1.000 20.59465 ? 115 LEU   A CA  1 
ATOM   896  C C   . LEU   A 1 115 ? -6.68237  26.35070 -31.72815 1.000 20.47423 ? 115 LEU   A C   1 
ATOM   897  O O   . LEU   A 1 115 ? -7.28228  25.46902 -32.36204 1.000 18.07907 ? 115 LEU   A O   1 
ATOM   898  C CB  . LEU   A 1 115 ? -4.75798  26.49106 -33.37022 1.000 18.85591 ? 115 LEU   A CB  1 
ATOM   899  C CG  . LEU   A 1 115 ? -5.39272  27.57705 -34.26008 1.000 21.78151 ? 115 LEU   A CG  1 
ATOM   900  C CD1 . LEU   A 1 115 ? -4.96385  29.00062 -33.82541 1.000 22.12611 ? 115 LEU   A CD1 1 
ATOM   901  C CD2 . LEU   A 1 115 ? -5.05425  27.34702 -35.74761 1.000 20.38601 ? 115 LEU   A CD2 1 
ATOM   902  N N   . ALA   A 1 116 ? -7.29735  27.16288 -30.86114 1.000 19.00019 ? 116 ALA   A N   1 
ATOM   903  C CA  . ALA   A 1 116 ? -8.73624  27.07991 -30.62245 1.000 21.04501 ? 116 ALA   A CA  1 
ATOM   904  C C   . ALA   A 1 116 ? -9.48957  27.70616 -31.78768 1.000 20.30631 ? 116 ALA   A C   1 
ATOM   905  O O   . ALA   A 1 116 ? -9.20443  28.83853 -32.18031 1.000 22.31718 ? 116 ALA   A O   1 
ATOM   906  C CB  . ALA   A 1 116 ? -9.11101  27.78310 -29.31648 1.000 22.23417 ? 116 ALA   A CB  1 
ATOM   907  N N   . CYS   A 1 117 ? -10.43712 26.95533 -32.35102 1.000 21.53571 ? 117 CYS   A N   1 
ATOM   908  C CA  . CYS   A 1 117 ? -11.13547 27.32524 -33.57805 1.000 24.12182 ? 117 CYS   A CA  1 
ATOM   909  C C   . CYS   A 1 117 ? -12.64704 27.17254 -33.41223 1.000 18.79459 ? 117 CYS   A C   1 
ATOM   910  O O   . CYS   A 1 117 ? -13.11824 26.30661 -32.67247 1.000 21.01821 ? 117 CYS   A O   1 
ATOM   911  C CB  . CYS   A 1 117 ? -10.64914 26.44352 -34.75671 1.000 22.32868 ? 117 CYS   A CB  1 
ATOM   912  S SG  . CYS   A 1 117 ? -9.01813  26.87712 -35.30853 1.000 24.39681 ? 117 CYS   A SG  1 
ATOM   913  N N   . TYR   A 1 118 ? -13.40836 28.00493 -34.13821 1.000 19.16909 ? 118 TYR   A N   1 
ATOM   914  C CA  . TYR   A 1 118 ? -14.86721 27.88611 -34.23909 1.000 25.01055 ? 118 TYR   A CA  1 
ATOM   915  C C   . TYR   A 1 118 ? -15.25741 28.10447 -35.68976 1.000 24.69465 ? 118 TYR   A C   1 
ATOM   916  O O   . TYR   A 1 118 ? -14.80463 29.06898 -36.30425 1.000 24.57816 ? 118 TYR   A O   1 
ATOM   917  C CB  . TYR   A 1 118 ? -15.58720 28.90881 -33.32493 1.000 24.08707 ? 118 TYR   A CB  1 
ATOM   918  C CG  . TYR   A 1 118 ? -15.21769 28.64915 -31.90014 1.000 24.89710 ? 118 TYR   A CG  1 
ATOM   919  C CD1 . TYR   A 1 118 ? -15.92054 27.70795 -31.14954 1.000 27.63224 ? 118 TYR   A CD1 1 
ATOM   920  C CD2 . TYR   A 1 118 ? -14.09546 29.25474 -31.32919 1.000 27.26312 ? 118 TYR   A CD2 1 
ATOM   921  C CE1 . TYR   A 1 118 ? -15.54545 27.40673 -29.86006 1.000 24.26675 ? 118 TYR   A CE1 1 
ATOM   922  C CE2 . TYR   A 1 118 ? -13.71309 28.96016 -30.02470 1.000 23.61934 ? 118 TYR   A CE2 1 
ATOM   923  C CZ  . TYR   A 1 118 ? -14.44987 28.01995 -29.30600 1.000 21.87020 ? 118 TYR   A CZ  1 
ATOM   924  O OH  . TYR   A 1 118 ? -14.08242 27.69110 -28.01204 1.000 27.00519 ? 118 TYR   A OH  1 
ATOM   925  N N   . ASN   A 1 119 ? -16.08475 27.20802 -36.24126 1.000 23.25340 ? 119 ASN   A N   1 
ATOM   926  C CA  . ASN   A 1 119 ? -16.56898 27.34577 -37.61880 1.000 27.64715 ? 119 ASN   A CA  1 
ATOM   927  C C   . ASN   A 1 119 ? -15.40872 27.42185 -38.61480 1.000 26.33051 ? 119 ASN   A C   1 
ATOM   928  O O   . ASN   A 1 119 ? -15.47468 28.10869 -39.63359 1.000 24.43040 ? 119 ASN   A O   1 
ATOM   929  C CB  . ASN   A 1 119 ? -17.49504 28.56149 -37.75656 1.000 27.41947 ? 119 ASN   A CB  1 
ATOM   930  C CG  . ASN   A 1 119 ? -18.69195 28.47222 -36.82175 1.000 34.22648 ? 119 ASN   A CG  1 
ATOM   931  O OD1 . ASN   A 1 119 ? -19.60433 27.68310 -37.03864 1.000 36.78838 ? 119 ASN   A OD1 1 
ATOM   932  N ND2 . ASN   A 1 119 ? -18.66707 29.25470 -35.75813 1.000 36.00250 ? 119 ASN   A ND2 1 
ATOM   933  N N   . GLY   A 1 120 ? -14.34718 26.67991 -38.34199 1.000 21.33360 ? 120 GLY   A N   1 
ATOM   934  C CA  . GLY   A 1 120 ? -13.22105 26.65318 -39.24802 1.000 22.56507 ? 120 GLY   A CA  1 
ATOM   935  C C   . GLY   A 1 120 ? -12.27549 27.82537 -39.14990 1.000 25.86399 ? 120 GLY   A C   1 
ATOM   936  O O   . GLY   A 1 120 ? -11.30429 27.86671 -39.91794 1.000 27.06615 ? 120 GLY   A O   1 
ATOM   937  N N   . SER   A 1 121 ? -12.51226 28.77862 -38.23075 1.000 21.55821 ? 121 SER   A N   1 
ATOM   938  C CA  . SER   A 1 121 ? -11.74844 30.01778 -38.12446 1.000 22.70476 ? 121 SER   A CA  1 
ATOM   939  C C   . SER   A 1 121 ? -11.05703 30.11620 -36.76670 1.000 23.39317 ? 121 SER   A C   1 
ATOM   940  O O   . SER   A 1 121 ? -11.67265 29.82585 -35.73093 1.000 23.71209 ? 121 SER   A O   1 
ATOM   941  C CB  . SER   A 1 121 ? -12.63417 31.27156 -38.31857 1.000 28.57298 ? 121 SER   A CB  1 
ATOM   942  O OG  . SER   A 1 121 ? -13.26948 31.26006 -39.58477 1.000 32.89943 ? 121 SER   A OG  1 
ATOM   943  N N   . PRO   A 1 122 ? -9.79959  30.55378 -36.73930 1.000 27.99084 ? 122 PRO   A N   1 
ATOM   944  C CA  . PRO   A 1 122 ? -9.02802  30.53182 -35.48714 1.000 20.25125 ? 122 PRO   A CA  1 
ATOM   945  C C   . PRO   A 1 122 ? -9.44985  31.63284 -34.52869 1.000 25.02953 ? 122 PRO   A C   1 
ATOM   946  O O   . PRO   A 1 122 ? -9.75445  32.76233 -34.92539 1.000 29.42968 ? 122 PRO   A O   1 
ATOM   947  C CB  . PRO   A 1 122 ? -7.58422  30.72452 -35.96874 1.000 25.20402 ? 122 PRO   A CB  1 
ATOM   948  C CG  . PRO   A 1 122 ? -7.74341  31.58951 -37.21353 1.000 30.08422 ? 122 PRO   A CG  1 
ATOM   949  C CD  . PRO   A 1 122 ? -9.00908  31.07072 -37.87339 1.000 30.36243 ? 122 PRO   A CD  1 
ATOM   950  N N   . SER   A 1 123 ? -9.49042  31.28381 -33.25042 1.000 23.43972 ? 123 SER   A N   1 
ATOM   951  C CA  . SER   A 1 123 ? -9.84824  32.23615 -32.20904 1.000 23.81294 ? 123 SER   A CA  1 
ATOM   952  C C   . SER   A 1 123 ? -8.64527  32.64390 -31.35790 1.000 21.83272 ? 123 SER   A C   1 
ATOM   953  O O   . SER   A 1 123 ? -8.49861  33.81960 -31.03591 1.000 24.82259 ? 123 SER   A O   1 
ATOM   954  C CB  . SER   A 1 123 ? -10.96603 31.64142 -31.33192 1.000 25.34154 ? 123 SER   A CB  1 
ATOM   955  O OG  . SER   A 1 123 ? -11.39539 32.53848 -30.32235 1.000 35.19079 ? 123 SER   A OG  1 
ATOM   956  N N   . GLY   A 1 124 ? -7.74780  31.71746 -31.04194 1.000 22.82749 ? 124 GLY   A N   1 
ATOM   957  C CA  . GLY   A 1 124 ? -6.57437  32.05470 -30.24517 1.000 20.50496 ? 124 GLY   A CA  1 
ATOM   958  C C   . GLY   A 1 124 ? -5.69318  30.83971 -30.03435 1.000 19.69284 ? 124 GLY   A C   1 
ATOM   959  O O   . GLY   A 1 124 ? -6.03905  29.70899 -30.40275 1.000 18.76975 ? 124 GLY   A O   1 
ATOM   960  N N   . VAL   A 1 125 ? -4.53994  31.08233 -29.42087 1.000 20.10040 ? 125 VAL   A N   1 
ATOM   961  C CA  . VAL   A 1 125 ? -3.52703  30.04786 -29.26809 1.000 16.02921 ? 125 VAL   A CA  1 
ATOM   962  C C   . VAL   A 1 125 ? -3.03122  30.03495 -27.82439 1.000 22.28507 ? 125 VAL   A C   1 
ATOM   963  O O   . VAL   A 1 125 ? -2.90361  31.09670 -27.19553 1.000 21.87033 ? 125 VAL   A O   1 
ATOM   964  C CB  . VAL   A 1 125 ? -2.38229  30.27741 -30.28290 1.000 20.57642 ? 125 VAL   A CB  1 
ATOM   965  C CG1 . VAL   A 1 125 ? -1.59456  31.51192 -29.93026 1.000 24.73493 ? 125 VAL   A CG1 1 
ATOM   966  C CG2 . VAL   A 1 125 ? -1.49001  29.02671 -30.43216 1.000 18.15838 ? 125 VAL   A CG2 1 
ATOM   967  N N   . TYR   A 1 126 ? -2.78066  28.83728 -27.28367 1.000 15.55727 ? 126 TYR   A N   1 
ATOM   968  C CA  . TYR   A 1 126 ? -2.24670  28.74173 -25.92190 1.000 19.81754 ? 126 TYR   A CA  1 
ATOM   969  C C   . TYR   A 1 126 ? -1.56033  27.39320 -25.72988 1.000 22.54944 ? 126 TYR   A C   1 
ATOM   970  O O   . TYR   A 1 126 ? -1.81535  26.42686 -26.45712 1.000 22.62757 ? 126 TYR   A O   1 
ATOM   971  C CB  . TYR   A 1 126 ? -3.34528  28.96876 -24.84060 1.000 20.00407 ? 126 TYR   A CB  1 
ATOM   972  C CG  . TYR   A 1 126 ? -4.58125  28.09701 -24.99786 1.000 19.48957 ? 126 TYR   A CG  1 
ATOM   973  C CD1 . TYR   A 1 126 ? -4.61241  26.80253 -24.50564 1.000 20.81385 ? 126 TYR   A CD1 1 
ATOM   974  C CD2 . TYR   A 1 126 ? -5.71513  28.57967 -25.62072 1.000 21.83540 ? 126 TYR   A CD2 1 
ATOM   975  C CE1 . TYR   A 1 126 ? -5.72072  25.98296 -24.68182 1.000 23.95461 ? 126 TYR   A CE1 1 
ATOM   976  C CE2 . TYR   A 1 126 ? -6.84481  27.76852 -25.79754 1.000 26.84021 ? 126 TYR   A CE2 1 
ATOM   977  C CZ  . TYR   A 1 126 ? -6.83352  26.47213 -25.31696 1.000 22.52575 ? 126 TYR   A CZ  1 
ATOM   978  O OH  . TYR   A 1 126 ? -7.93622  25.66821 -25.47563 1.000 24.85547 ? 126 TYR   A OH  1 
ATOM   979  N N   . GLN   A 1 127 ? -0.70250  27.33445 -24.70958 1.000 19.22969 ? 127 GLN   A N   1 
ATOM   980  C CA  . GLN   A 1 127 ? 0.10123   26.15858 -24.41477 1.000 21.61284 ? 127 GLN   A CA  1 
ATOM   981  C C   . GLN   A 1 127 ? -0.59340  25.26543 -23.38559 1.000 22.92508 ? 127 GLN   A C   1 
ATOM   982  O O   . GLN   A 1 127 ? -1.11071  25.76513 -22.38353 1.000 24.93906 ? 127 GLN   A O   1 
ATOM   983  C CB  . GLN   A 1 127 ? 1.44290   26.58833 -23.82329 1.000 26.49345 ? 127 GLN   A CB  1 
ATOM   984  C CG  . GLN   A 1 127 ? 2.49580   26.96765 -24.81043 1.000 28.45228 ? 127 GLN   A CG  1 
ATOM   985  C CD  . GLN   A 1 127 ? 3.09511   25.79412 -25.54956 1.000 30.37968 ? 127 GLN   A CD  1 
ATOM   986  O OE1 . GLN   A 1 127 ? 2.74794   25.56025 -26.69456 1.000 32.55062 ? 127 GLN   A OE1 1 
ATOM   987  N NE2 . GLN   A 1 127 ? 4.00835   25.06478 -24.91198 1.000 30.87589 ? 127 GLN   A NE2 1 
ATOM   988  N N   . CYS   A 1 128 ? -0.50045  23.94179 -23.57825 1.000 19.28364 ? 128 CYS   A N   1 
ATOM   989  C CA  . CYS   A 1 128 ? -1.09982  22.94039 -22.69273 1.000 22.31137 ? 128 CYS   A CA  1 
ATOM   990  C C   . CYS   A 1 128 ? -0.11000  21.81892 -22.40318 1.000 23.38074 ? 128 CYS   A C   1 
ATOM   991  O O   . CYS   A 1 128 ? 0.74440   21.51213 -23.22369 1.000 24.04755 ? 128 CYS   A O   1 
ATOM   992  C CB  . CYS   A 1 128 ? -2.34113  22.28407 -23.32690 1.000 23.33898 ? 128 CYS   A CB  1 
ATOM   993  S SG  . CYS   A 1 128 ? -3.84292  23.27279 -23.30460 1.000 30.28743 ? 128 CYS   A SG  1 
ATOM   994  N N   . ALA   A 1 129 ? -0.25246  21.16576 -21.25170 1.000 24.45835 ? 129 ALA   A N   1 
ATOM   995  C CA  . ALA   A 1 129 ? 0.51063   19.95389 -20.95850 1.000 22.52075 ? 129 ALA   A CA  1 
ATOM   996  C C   . ALA   A 1 129 ? -0.42707  18.76037 -20.84123 1.000 24.97779 ? 129 ALA   A C   1 
ATOM   997  O O   . ALA   A 1 129 ? -1.49261  18.85631 -20.22000 1.000 24.91256 ? 129 ALA   A O   1 
ATOM   998  C CB  . ALA   A 1 129 ? 1.31229   20.08468 -19.65131 1.000 26.40446 ? 129 ALA   A CB  1 
ATOM   999  N N   . MET   A 1 130 ? -0.02575  17.63389 -21.42507 1.000 20.85118 ? 130 MET   A N   1 
ATOM   1000 C CA  . MET   A 1 130 ? -0.69853  16.36279 -21.18762 1.000 22.75994 ? 130 MET   A CA  1 
ATOM   1001 C C   . MET   A 1 130 ? -0.44335  15.95314 -19.74947 1.000 22.51819 ? 130 MET   A C   1 
ATOM   1002 O O   . MET   A 1 130 ? 0.68806   15.61196 -19.39434 1.000 21.08965 ? 130 MET   A O   1 
ATOM   1003 C CB  . MET   A 1 130 ? -0.17968  15.30455 -22.16747 1.000 17.75046 ? 130 MET   A CB  1 
ATOM   1004 C CG  . MET   A 1 130 ? -0.97809  14.01109 -22.34427 1.000 24.96034 ? 130 MET   A CG  1 
ATOM   1005 S SD  . MET   A 1 130 ? -2.76330  14.14577 -22.38223 1.000 27.23024 ? 130 MET   A SD  1 
ATOM   1006 C CE  . MET   A 1 130 ? -2.95660  14.90711 -23.98876 1.000 23.54751 ? 130 MET   A CE  1 
ATOM   1007 N N   . ARG   A 1 131 ? -1.47614  15.99137 -18.91053 1.000 19.80355 ? 131 ARG   A N   1 
ATOM   1008 C CA  . ARG   A 1 131 ? -1.30403  15.57719 -17.52670 1.000 21.88541 ? 131 ARG   A CA  1 
ATOM   1009 C C   . ARG   A 1 131 ? -1.01649  14.07439 -17.41772 1.000 24.93975 ? 131 ARG   A C   1 
ATOM   1010 O O   . ARG   A 1 131 ? -1.35020  13.28797 -18.31480 1.000 23.22097 ? 131 ARG   A O   1 
ATOM   1011 C CB  . ARG   A 1 131 ? -2.55013  15.91403 -16.69558 1.000 24.57135 ? 131 ARG   A CB  1 
ATOM   1012 C CG  . ARG   A 1 131 ? -3.01668  17.38673 -16.72525 1.000 23.24993 ? 131 ARG   A CG  1 
ATOM   1013 C CD  . ARG   A 1 131 ? -1.95987  18.34964 -16.21411 1.000 25.74255 ? 131 ARG   A CD  1 
ATOM   1014 N NE  . ARG   A 1 131 ? -1.32510  17.86614 -14.99548 1.000 27.43613 ? 131 ARG   A NE  1 
ATOM   1015 C CZ  . ARG   A 1 131 ? -0.29792  18.46207 -14.40684 1.000 27.53046 ? 131 ARG   A CZ  1 
ATOM   1016 N NH1 . ARG   A 1 131 ? 0.23633   19.56470 -14.90409 1.000 21.26041 ? 131 ARG   A NH1 1 
ATOM   1017 N NH2 . ARG   A 1 131 ? 0.21198   17.93243 -13.29939 1.000 24.46456 ? 131 ARG   A NH2 1 
ATOM   1018 N N   . PRO   A 1 132 ? -0.40869  13.64471 -16.30987 1.000 22.72853 ? 132 PRO   A N   1 
ATOM   1019 C CA  . PRO   A 1 132 ? -0.25438  12.19254 -16.08178 1.000 25.42526 ? 132 PRO   A CA  1 
ATOM   1020 C C   . PRO   A 1 132 ? -1.57014  11.43291 -16.12059 1.000 27.62451 ? 132 PRO   A C   1 
ATOM   1021 O O   . PRO   A 1 132 ? -1.56823  10.24410 -16.45133 1.000 26.67680 ? 132 PRO   A O   1 
ATOM   1022 C CB  . PRO   A 1 132 ? 0.41098   12.11816 -14.69613 1.000 23.95846 ? 132 PRO   A CB  1 
ATOM   1023 C CG  . PRO   A 1 132 ? 1.19790   13.43984 -14.60415 1.000 26.69477 ? 132 PRO   A CG  1 
ATOM   1024 C CD  . PRO   A 1 132 ? 0.28463   14.45079 -15.28666 1.000 22.71200 ? 132 PRO   A CD  1 
ATOM   1025 N N   . ASN   A 1 133 ? -2.70198  12.08772 -15.84106 1.000 26.98972 ? 133 ASN   A N   1 
ATOM   1026 C CA  . ASN   A 1 133 ? -3.99607  11.43607 -15.96084 1.000 27.16800 ? 133 ASN   A CA  1 
ATOM   1027 C C   . ASN   A 1 133 ? -4.65489  11.65475 -17.31836 1.000 29.53059 ? 133 ASN   A C   1 
ATOM   1028 O O   . ASN   A 1 133 ? -5.85291  11.38169 -17.45744 1.000 26.80409 ? 133 ASN   A O   1 
ATOM   1029 C CB  . ASN   A 1 133 ? -4.93258  11.87856 -14.83931 1.000 28.76474 ? 133 ASN   A CB  1 
ATOM   1030 C CG  . ASN   A 1 133 ? -5.36603  13.31665 -14.95682 1.000 30.46349 ? 133 ASN   A CG  1 
ATOM   1031 O OD1 . ASN   A 1 133 ? -4.96170  14.05545 -15.87288 1.000 22.70054 ? 133 ASN   A OD1 1 
ATOM   1032 N ND2 . ASN   A 1 133 ? -6.22588  13.72680 -14.03699 1.000 26.65151 ? 133 ASN   A ND2 1 
ATOM   1033 N N   . PHE   A 1 134 ? -3.89743  12.12349 -18.31543 1.000 25.66795 ? 134 PHE   A N   1 
ATOM   1034 C CA  . PHE   A 1 134 ? -4.33128  12.19233 -19.71920 1.000 25.68434 ? 134 PHE   A CA  1 
ATOM   1035 C C   . PHE   A 1 134 ? -5.47559  13.18301 -19.95662 1.000 25.29020 ? 134 PHE   A C   1 
ATOM   1036 O O   . PHE   A 1 134 ? -6.31651  12.98248 -20.85228 1.000 26.83833 ? 134 PHE   A O   1 
ATOM   1037 C CB  . PHE   A 1 134 ? -4.69050  10.80785 -20.26945 1.000 22.24763 ? 134 PHE   A CB  1 
ATOM   1038 C CG  . PHE   A 1 134 ? -3.53329  9.84858  -20.26626 1.000 33.79421 ? 134 PHE   A CG  1 
ATOM   1039 C CD1 . PHE   A 1 134 ? -2.59182  9.88456  -21.28366 1.000 33.08444 ? 134 PHE   A CD1 1 
ATOM   1040 C CD2 . PHE   A 1 134 ? -3.38315  8.91396  -19.25533 1.000 29.38695 ? 134 PHE   A CD2 1 
ATOM   1041 C CE1 . PHE   A 1 134 ? -1.49950  8.99599  -21.27753 1.000 41.68065 ? 134 PHE   A CE1 1 
ATOM   1042 C CE2 . PHE   A 1 134 ? -2.31372  8.03667  -19.25112 1.000 33.19186 ? 134 PHE   A CE2 1 
ATOM   1043 C CZ  . PHE   A 1 134 ? -1.37465  8.07240  -20.26263 1.000 34.95396 ? 134 PHE   A CZ  1 
ATOM   1044 N N   . THR   A 1 135 ? -5.48300  14.27498 -19.19756 1.000 25.57268 ? 135 THR   A N   1 
ATOM   1045 C CA  . THR   A 1 135 ? -6.32760  15.43411 -19.43332 1.000 22.30492 ? 135 THR   A CA  1 
ATOM   1046 C C   . THR   A 1 135 ? -5.44813  16.66242 -19.69442 1.000 19.80855 ? 135 THR   A C   1 
ATOM   1047 O O   . THR   A 1 135 ? -4.24188  16.65901 -19.42392 1.000 22.08923 ? 135 THR   A O   1 
ATOM   1048 C CB  . THR   A 1 135 ? -7.26503  15.67898 -18.23279 1.000 25.18174 ? 135 THR   A CB  1 
ATOM   1049 O OG1 . THR   A 1 135 ? -6.49113  16.04094 -17.08363 1.000 23.40404 ? 135 THR   A OG1 1 
ATOM   1050 C CG2 . THR   A 1 135 ? -8.06793  14.41905 -17.90220 1.000 24.50263 ? 135 THR   A CG2 1 
ATOM   1051 N N   . ILE   A 1 136 ? -6.04998  17.70698 -20.25537 1.000 22.22389 ? 136 ILE   A N   1 
ATOM   1052 C CA  . ILE   A 1 136 ? -5.40042  19.00050 -20.42638 1.000 24.83278 ? 136 ILE   A CA  1 
ATOM   1053 C C   . ILE   A 1 136 ? -6.31605  20.06774 -19.84625 1.000 23.20277 ? 136 ILE   A C   1 
ATOM   1054 O O   . ILE   A 1 136 ? -7.53625  19.89099 -19.75194 1.000 24.77677 ? 136 ILE   A O   1 
ATOM   1055 C CB  . ILE   A 1 136 ? -5.07132  19.32463 -21.90195 1.000 24.50541 ? 136 ILE   A CB  1 
ATOM   1056 C CG1 . ILE   A 1 136 ? -6.37360  19.44850 -22.70824 1.000 22.76750 ? 136 ILE   A CG1 1 
ATOM   1057 C CG2 . ILE   A 1 136 ? -4.10381  18.27243 -22.49734 1.000 24.78070 ? 136 ILE   A CG2 1 
ATOM   1058 C CD1 . ILE   A 1 136 ? -6.19021  19.90619 -24.13639 1.000 21.89054 ? 136 ILE   A CD1 1 
ATOM   1059 N N   . LYS   A 1 137 ? -5.71232  21.16226 -19.41428 1.000 24.12073 ? 137 LYS   A N   1 
ATOM   1060 C CA  . LYS   A 1 137 ? -6.43565  22.30969 -18.87204 1.000 26.54047 ? 137 LYS   A CA  1 
ATOM   1061 C C   . LYS   A 1 137 ? -6.51474  23.34438 -19.99333 1.000 28.08666 ? 137 LYS   A C   1 
ATOM   1062 O O   . LYS   A 1 137 ? -5.65186  24.21487 -20.12707 1.000 28.06395 ? 137 LYS   A O   1 
ATOM   1063 C CB  . LYS   A 1 137 ? -5.73161  22.86189 -17.62697 1.000 28.06138 ? 137 LYS   A CB  1 
ATOM   1064 C CG  . LYS   A 1 137 ? -5.51699  21.84350 -16.50178 1.000 38.61014 ? 137 LYS   A CG  1 
ATOM   1065 C CD  . LYS   A 1 137 ? -4.65735  22.42733 -15.36502 1.000 37.89270 ? 137 LYS   A CD  1 
ATOM   1066 C CE  . LYS   A 1 137 ? -4.69894  21.57592 -14.09202 1.000 46.84805 ? 137 LYS   A CE  1 
ATOM   1067 N NZ  . LYS   A 1 137 ? -5.17671  20.16905 -14.30162 1.000 43.80816 ? 137 LYS   A NZ  1 
ATOM   1068 N N   . GLY   A 1 138 ? -7.57344  23.25172 -20.79923 1.000 25.50500 ? 138 GLY   A N   1 
ATOM   1069 C CA  . GLY   A 1 138 ? -7.74981  24.09093 -21.95869 1.000 23.16369 ? 138 GLY   A CA  1 
ATOM   1070 C C   . GLY   A 1 138 ? -8.82766  25.14371 -21.77734 1.000 24.39915 ? 138 GLY   A C   1 
ATOM   1071 O O   . GLY   A 1 138 ? -9.25352  25.46376 -20.66969 1.000 24.50824 ? 138 GLY   A O   1 
ATOM   1072 N N   . SER   A 1 139 ? -9.23347  25.71907 -22.90952 1.000 21.36134 ? 139 SER   A N   1 
ATOM   1073 C CA  . SER   A 1 139 ? -10.31112 26.71303 -22.94931 1.000 22.80925 ? 139 SER   A CA  1 
ATOM   1074 C C   . SER   A 1 139 ? -11.10332 26.43398 -24.21717 1.000 23.75172 ? 139 SER   A C   1 
ATOM   1075 O O   . SER   A 1 139 ? -10.69272 26.85346 -25.30444 1.000 24.89520 ? 139 SER   A O   1 
ATOM   1076 C CB  . SER   A 1 139 ? -9.78140  28.14387 -22.96236 1.000 20.73144 ? 139 SER   A CB  1 
ATOM   1077 O OG  . SER   A 1 139 ? -10.83784 29.08693 -23.15086 1.000 25.84903 ? 139 SER   A OG  1 
ATOM   1078 N N   . PHE   A 1 140 ? -12.23486 25.75364 -24.07678 1.000 18.81744 ? 140 PHE   A N   1 
ATOM   1079 C CA  . PHE   A 1 140 ? -12.98862 25.27287 -25.23048 1.000 22.71329 ? 140 PHE   A CA  1 
ATOM   1080 C C   . PHE   A 1 140 ? -14.47968 25.48335 -24.99361 1.000 24.91269 ? 140 PHE   A C   1 
ATOM   1081 O O   . PHE   A 1 140 ? -14.99262 25.08391 -23.94915 1.000 27.89011 ? 140 PHE   A O   1 
ATOM   1082 C CB  . PHE   A 1 140 ? -12.73782 23.77777 -25.47916 1.000 21.05691 ? 140 PHE   A CB  1 
ATOM   1083 C CG  . PHE   A 1 140 ? -11.30400 23.40535 -25.82872 1.000 20.50223 ? 140 PHE   A CG  1 
ATOM   1084 C CD1 . PHE   A 1 140 ? -10.78766 23.67816 -27.08347 1.000 28.37561 ? 140 PHE   A CD1 1 
ATOM   1085 C CD2 . PHE   A 1 140 ? -10.51042 22.72281 -24.92320 1.000 22.49234 ? 140 PHE   A CD2 1 
ATOM   1086 C CE1 . PHE   A 1 140 ? -9.49896  23.30233 -27.41673 1.000 21.52794 ? 140 PHE   A CE1 1 
ATOM   1087 C CE2 . PHE   A 1 140 ? -9.21718  22.33804 -25.24890 1.000 22.37591 ? 140 PHE   A CE2 1 
ATOM   1088 C CZ  . PHE   A 1 140 ? -8.71186  22.63763 -26.49822 1.000 23.21303 ? 140 PHE   A CZ  1 
ATOM   1089 N N   . LEU   A 1 141 ? -15.16853 26.07741 -25.96955 1.000 22.30378 ? 141 LEU   A N   1 
ATOM   1090 C CA  . LEU   A 1 141 ? -16.61764 26.28061 -25.98700 1.000 24.85425 ? 141 LEU   A CA  1 
ATOM   1091 C C   . LEU   A 1 141 ? -17.28171 25.28950 -26.95671 1.000 24.37896 ? 141 LEU   A C   1 
ATOM   1092 O O   . LEU   A 1 141 ? -16.61743 24.49325 -27.61884 1.000 23.46140 ? 141 LEU   A O   1 
ATOM   1093 C CB  . LEU   A 1 141 ? -16.92046 27.72245 -26.38244 1.000 23.53327 ? 141 LEU   A CB  1 
ATOM   1094 C CG  . LEU   A 1 141 ? -16.35359 28.82288 -25.48298 1.000 28.04616 ? 141 LEU   A CG  1 
ATOM   1095 C CD1 . LEU   A 1 141 ? -16.66512 30.20423 -26.08147 1.000 32.34368 ? 141 LEU   A CD1 1 
ATOM   1096 C CD2 . LEU   A 1 141 ? -16.93352 28.71345 -24.08904 1.000 32.78297 ? 141 LEU   A CD2 1 
ATOM   1097 N N   . ASN   A 1 142 ? -18.61036 25.32113 -27.01944 1.000 23.90860 ? 142 ASN   A N   1 
ATOM   1098 C CA  . ASN   A 1 142 ? -19.33620 24.55634 -28.03675 1.000 25.14232 ? 142 ASN   A CA  1 
ATOM   1099 C C   . ASN   A 1 142 ? -18.80503 24.86385 -29.43502 1.000 27.03016 ? 142 ASN   A C   1 
ATOM   1100 O O   . ASN   A 1 142 ? -18.53552 26.01661 -29.78044 1.000 24.83566 ? 142 ASN   A O   1 
ATOM   1101 C CB  . ASN   A 1 142 ? -20.84409 24.86173 -27.96535 1.000 29.26067 ? 142 ASN   A CB  1 
ATOM   1102 C CG  . ASN   A 1 142 ? -21.54245 24.12725 -26.82186 1.000 35.16334 ? 142 ASN   A CG  1 
ATOM   1103 O OD1 . ASN   A 1 142 ? -21.22813 22.97784 -26.52533 1.000 34.49171 ? 142 ASN   A OD1 1 
ATOM   1104 N ND2 . ASN   A 1 142 ? -22.49273 24.79266 -26.17865 1.000 39.37547 ? 142 ASN   A ND2 1 
ATOM   1105 N N   . GLY   A 1 143 ? -18.66176 23.81984 -30.24642 1.000 28.07857 ? 143 GLY   A N   1 
ATOM   1106 C CA  . GLY   A 1 143 ? -18.14309 23.98430 -31.58637 1.000 27.65989 ? 143 GLY   A CA  1 
ATOM   1107 C C   . GLY   A 1 143 ? -16.63720 24.08276 -31.69432 1.000 25.76214 ? 143 GLY   A C   1 
ATOM   1108 O O   . GLY   A 1 143 ? -16.12594 24.28135 -32.80399 1.000 24.52991 ? 143 GLY   A O   1 
ATOM   1109 N N   . SER   A 1 144 ? -15.89738 23.94997 -30.58966 1.000 25.65160 ? 144 SER   A N   1 
ATOM   1110 C CA  . SER   A 1 144 ? -14.44128 23.93677 -30.67001 1.000 21.33091 ? 144 SER   A CA  1 
ATOM   1111 C C   . SER   A 1 144 ? -13.87132 22.58930 -31.09423 1.000 23.40037 ? 144 SER   A C   1 
ATOM   1112 O O   . SER   A 1 144 ? -12.65615 22.49582 -31.35478 1.000 19.23402 ? 144 SER   A O   1 
ATOM   1113 C CB  . SER   A 1 144 ? -13.85041 24.32036 -29.30081 1.000 21.60916 ? 144 SER   A CB  1 
ATOM   1114 O OG  . SER   A 1 144 ? -14.33548 23.39790 -28.29787 1.000 24.27302 ? 144 SER   A OG  1 
ATOM   1115 N N   . CYS   A 1 145 ? -14.69156 21.53722 -31.13135 1.000 20.10821 ? 145 CYS   A N   1 
ATOM   1116 C CA  . CYS   A 1 145 ? -14.14848 20.21136 -31.38619 1.000 16.42276 ? 145 CYS   A CA  1 
ATOM   1117 C C   . CYS   A 1 145 ? -13.50264 20.17897 -32.76308 1.000 20.28690 ? 145 CYS   A C   1 
ATOM   1118 O O   . CYS   A 1 145 ? -13.88850 20.92283 -33.67211 1.000 17.29483 ? 145 CYS   A O   1 
ATOM   1119 C CB  . CYS   A 1 145 ? -15.22814 19.14053 -31.23065 1.000 20.71928 ? 145 CYS   A CB  1 
ATOM   1120 S SG  . CYS   A 1 145 ? -15.53877 18.82053 -29.44568 1.000 24.54316 ? 145 CYS   A SG  1 
ATOM   1121 N N   . GLY   A 1 146 ? -12.44653 19.36817 -32.88346 1.000 19.93518 ? 146 GLY   A N   1 
ATOM   1122 C CA  . GLY   A 1 146 ? -11.63081 19.39274 -34.08445 1.000 18.35608 ? 146 GLY   A CA  1 
ATOM   1123 C C   . GLY   A 1 146 ? -10.51700 20.41786 -34.07244 1.000 22.37538 ? 146 GLY   A C   1 
ATOM   1124 O O   . GLY   A 1 146 ? -9.65458  20.37069 -34.95772 1.000 21.37764 ? 146 GLY   A O   1 
ATOM   1125 N N   . SER   A 1 147 ? -10.47608 21.32666 -33.08433 1.000 18.61161 ? 147 SER   A N   1 
ATOM   1126 C CA  . SER   A 1 147 ? -9.26205  22.11263 -32.86314 1.000 19.92014 ? 147 SER   A CA  1 
ATOM   1127 C C   . SER   A 1 147 ? -8.10919  21.16794 -32.54081 1.000 16.53674 ? 147 SER   A C   1 
ATOM   1128 O O   . SER   A 1 147 ? -8.30533  20.11276 -31.92368 1.000 21.04260 ? 147 SER   A O   1 
ATOM   1129 C CB  . SER   A 1 147 ? -9.45939  23.11352 -31.70508 1.000 19.16199 ? 147 SER   A CB  1 
ATOM   1130 O OG  . SER   A 1 147 ? -10.50837 24.03796 -32.01183 1.000 20.30257 ? 147 SER   A OG  1 
ATOM   1131 N N   . VAL   A 1 148 ? -6.90631  21.53906 -32.95197 1.000 18.40323 ? 148 VAL   A N   1 
ATOM   1132 C CA  . VAL   A 1 148 ? -5.77696  20.62213 -32.84861 1.000 16.63998 ? 148 VAL   A CA  1 
ATOM   1133 C C   . VAL   A 1 148 ? -4.67556  21.19988 -31.95505 1.000 18.99137 ? 148 VAL   A C   1 
ATOM   1134 O O   . VAL   A 1 148 ? -4.53405  22.42099 -31.78617 1.000 19.13454 ? 148 VAL   A O   1 
ATOM   1135 C CB  . VAL   A 1 148 ? -5.21498  20.24381 -34.24903 1.000 17.02571 ? 148 VAL   A CB  1 
ATOM   1136 C CG1 . VAL   A 1 148 ? -6.29215  19.45626 -35.06163 1.000 20.91676 ? 148 VAL   A CG1 1 
ATOM   1137 C CG2 . VAL   A 1 148 ? -4.70805  21.47845 -35.02805 1.000 22.80909 ? 148 VAL   A CG2 1 
ATOM   1138 N N   . GLY   A 1 149 ? -3.89835  20.28787 -31.37360 1.000 19.25552 ? 149 GLY   A N   1 
ATOM   1139 C CA  . GLY   A 1 149 ? -2.65685  20.61443 -30.69532 1.000 19.54050 ? 149 GLY   A CA  1 
ATOM   1140 C C   . GLY   A 1 149 ? -1.44423  20.17482 -31.50635 1.000 21.94596 ? 149 GLY   A C   1 
ATOM   1141 O O   . GLY   A 1 149 ? -1.51535  19.22722 -32.29146 1.000 19.15536 ? 149 GLY   A O   1 
ATOM   1142 N N   . PHE   A 1 150 ? -0.32060  20.86052 -31.31070 1.000 21.09792 ? 150 PHE   A N   1 
ATOM   1143 C CA  . PHE   A 1 150 ? 0.83089   20.65222 -32.18558 1.000 21.49037 ? 150 PHE   A CA  1 
ATOM   1144 C C   . PHE   A 1 150 ? 2.08929   21.22905 -31.56152 1.000 18.31419 ? 150 PHE   A C   1 
ATOM   1145 O O   . PHE   A 1 150 ? 2.03799   22.13623 -30.71877 1.000 18.15032 ? 150 PHE   A O   1 
ATOM   1146 C CB  . PHE   A 1 150 ? 0.63037   21.30339 -33.56225 1.000 18.14944 ? 150 PHE   A CB  1 
ATOM   1147 C CG  . PHE   A 1 150 ? 0.47120   22.80494 -33.48922 1.000 20.77400 ? 150 PHE   A CG  1 
ATOM   1148 C CD1 . PHE   A 1 150 ? -0.75116  23.36315 -33.10627 1.000 22.46091 ? 150 PHE   A CD1 1 
ATOM   1149 C CD2 . PHE   A 1 150 ? 1.54049   23.66171 -33.76714 1.000 22.08871 ? 150 PHE   A CD2 1 
ATOM   1150 C CE1 . PHE   A 1 150 ? -0.91442  24.75131 -33.02134 1.000 23.81546 ? 150 PHE   A CE1 1 
ATOM   1151 C CE2 . PHE   A 1 150 ? 1.37458   25.04108 -33.69710 1.000 22.94099 ? 150 PHE   A CE2 1 
ATOM   1152 C CZ  . PHE   A 1 150 ? 0.13463   25.58595 -33.31518 1.000 21.73597 ? 150 PHE   A CZ  1 
ATOM   1153 N N   . ASN   A 1 151 ? 3.22394   20.70186 -32.03869 1.000 16.67678 ? 151 ASN   A N   1 
ATOM   1154 C CA  . ASN   A 1 151 ? 4.55958   21.26223 -31.87261 1.000 23.64970 ? 151 ASN   A CA  1 
ATOM   1155 C C   . ASN   A 1 151 ? 5.15195   21.56774 -33.24873 1.000 23.99092 ? 151 ASN   A C   1 
ATOM   1156 O O   . ASN   A 1 151 ? 4.74422   20.99974 -34.26432 1.000 25.62616 ? 151 ASN   A O   1 
ATOM   1157 C CB  . ASN   A 1 151 ? 5.49116   20.28599 -31.12849 1.000 20.99735 ? 151 ASN   A CB  1 
ATOM   1158 C CG  . ASN   A 1 151 ? 5.11234   20.10120 -29.65262 1.000 28.02333 ? 151 ASN   A CG  1 
ATOM   1159 O OD1 . ASN   A 1 151 ? 4.26303   19.27227 -29.30894 1.000 26.77468 ? 151 ASN   A OD1 1 
ATOM   1160 N ND2 . ASN   A 1 151 ? 5.75933   20.85523 -28.78095 1.000 29.17538 ? 151 ASN   A ND2 1 
ATOM   1161 N N   . ILE   A 1 152 ? 6.13857   22.45775 -33.29048 1.000 24.27857 ? 152 ILE   A N   1 
ATOM   1162 C CA  . ILE   A 1 152 ? 6.92334   22.67126 -34.50375 1.000 27.67651 ? 152 ILE   A CA  1 
ATOM   1163 C C   . ILE   A 1 152 ? 8.38492   22.37486 -34.20008 1.000 36.09885 ? 152 ILE   A C   1 
ATOM   1164 O O   . ILE   A 1 152 ? 8.87333   22.68241 -33.10752 1.000 31.59812 ? 152 ILE   A O   1 
ATOM   1165 C CB  . ILE   A 1 152 ? 6.77317   24.09965 -35.06381 1.000 26.70265 ? 152 ILE   A CB  1 
ATOM   1166 C CG1 . ILE   A 1 152 ? 5.30090   24.51558 -35.12848 1.000 24.99231 ? 152 ILE   A CG1 1 
ATOM   1167 C CG2 . ILE   A 1 152 ? 7.37853   24.17765 -36.46562 1.000 31.82611 ? 152 ILE   A CG2 1 
ATOM   1168 C CD1 . ILE   A 1 152 ? 5.07857   25.77425 -35.87405 1.000 28.20033 ? 152 ILE   A CD1 1 
ATOM   1169 N N   . ASP   A 1 153 ? 9.08212   21.75192 -35.15415 1.000 35.38774 ? 153 ASP   A N   1 
ATOM   1170 C CA  . ASP   A 1 153 ? 10.54059  21.83146 -35.18233 1.000 42.63161 ? 153 ASP   A CA  1 
ATOM   1171 C C   . ASP   A 1 153 ? 10.98680  22.30915 -36.56204 1.000 42.33905 ? 153 ASP   A C   1 
ATOM   1172 O O   . ASP   A 1 153 ? 10.53903  21.78916 -37.59175 1.000 43.90339 ? 153 ASP   A O   1 
ATOM   1173 C CB  . ASP   A 1 153 ? 11.23216  20.51638 -34.73174 1.000 44.43402 ? 153 ASP   A CB  1 
ATOM   1174 C CG  . ASP   A 1 153 ? 11.22509  19.40420 -35.77935 1.000 56.64850 ? 153 ASP   A CG  1 
ATOM   1175 O OD1 . ASP   A 1 153 ? 11.87864  18.37177 -35.51244 1.000 66.79901 ? 153 ASP   A OD1 1 
ATOM   1176 O OD2 . ASP   A 1 153 ? 10.54714  19.48606 -36.81700 1.000 60.50332 ? 153 ASP   A OD2 1 
ATOM   1177 N N   . TYR   A 1 154 ? 11.81536  23.35350 -36.56692 1.000 42.49015 ? 154 TYR   A N   1 
ATOM   1178 C CA  . TYR   A 1 154 ? 12.23376  24.02677 -37.78808 1.000 41.76183 ? 154 TYR   A CA  1 
ATOM   1179 C C   . TYR   A 1 154 ? 11.01787  24.28261 -38.66502 1.000 40.56675 ? 154 TYR   A C   1 
ATOM   1180 O O   . TYR   A 1 154 ? 10.31329  25.28093 -38.49723 1.000 44.65911 ? 154 TYR   A O   1 
ATOM   1181 C CB  . TYR   A 1 154 ? 13.29736  23.20640 -38.53074 1.000 43.03218 ? 154 TYR   A CB  1 
ATOM   1182 N N   . ASP   A 1 155 ? 10.72501  23.36228 -39.57034 1.000 38.40989 ? 155 ASP   A N   1 
ATOM   1183 C CA  . ASP   A 1 155 ? 9.63581   23.56021 -40.50957 1.000 38.05261 ? 155 ASP   A CA  1 
ATOM   1184 C C   . ASP   A 1 155 ? 8.54312   22.49888 -40.43490 1.000 38.04203 ? 155 ASP   A C   1 
ATOM   1185 O O   . ASP   A 1 155 ? 7.52729   22.63351 -41.13390 1.000 35.34222 ? 155 ASP   A O   1 
ATOM   1186 C CB  . ASP   A 1 155 ? 10.20638  23.65047 -41.93175 1.000 38.43476 ? 155 ASP   A CB  1 
ATOM   1187 C CG  . ASP   A 1 155 ? 10.56513  22.28720 -42.50294 1.000 46.01788 ? 155 ASP   A CG  1 
ATOM   1188 O OD1 . ASP   A 1 155 ? 10.13370  21.99312 -43.64179 1.000 53.21319 ? 155 ASP   A OD1 1 
ATOM   1189 O OD2 . ASP   A 1 155 ? 11.31593  21.53018 -41.82335 1.000 41.80989 ? 155 ASP   A OD2 1 
ATOM   1190 N N   . CYS   A 1 156 ? 8.70230   21.47387 -39.59695 1.000 35.90810 ? 156 CYS   A N   1 
ATOM   1191 C CA  . CYS   A 1 156 ? 7.79360   20.33164 -39.54494 1.000 28.33201 ? 156 CYS   A CA  1 
ATOM   1192 C C   . CYS   A 1 156 ? 6.77295   20.49820 -38.41724 1.000 31.18623 ? 156 CYS   A C   1 
ATOM   1193 O O   . CYS   A 1 156 ? 7.14906   20.71995 -37.26110 1.000 27.83739 ? 156 CYS   A O   1 
ATOM   1194 C CB  . CYS   A 1 156 ? 8.57865   19.03025 -39.36425 1.000 31.71211 ? 156 CYS   A CB  1 
ATOM   1195 S SG  . CYS   A 1 156 ? 7.61763   17.47690 -39.33906 1.000 34.92802 ? 156 CYS   A SG  1 
ATOM   1196 N N   . VAL   A 1 157 ? 5.48997   20.39032 -38.75555 1.000 23.38076 ? 157 VAL   A N   1 
ATOM   1197 C CA  . VAL   A 1 157 ? 4.40887   20.46714 -37.76489 1.000 24.37872 ? 157 VAL   A CA  1 
ATOM   1198 C C   . VAL   A 1 157 ? 4.05551   19.05212 -37.33511 1.000 26.56769 ? 157 VAL   A C   1 
ATOM   1199 O O   . VAL   A 1 157 ? 3.55952   18.26317 -38.14617 1.000 24.45964 ? 157 VAL   A O   1 
ATOM   1200 C CB  . VAL   A 1 157 ? 3.16100   21.17599 -38.32425 1.000 22.82603 ? 157 VAL   A CB  1 
ATOM   1201 C CG1 . VAL   A 1 157 ? 2.02171   21.23845 -37.21439 1.000 23.10987 ? 157 VAL   A CG1 1 
ATOM   1202 C CG2 . VAL   A 1 157 ? 3.48838   22.56867 -38.86018 1.000 25.88558 ? 157 VAL   A CG2 1 
ATOM   1203 N N   . SER   A 1 158 ? 4.27425   18.73786 -36.05068 1.000 23.75229 ? 158 SER   A N   1 
ATOM   1204 C CA  . SER   A 1 158 ? 3.86691   17.46346 -35.46631 1.000 19.50815 ? 158 SER   A CA  1 
ATOM   1205 C C   . SER   A 1 158 ? 2.53724   17.67124 -34.74424 1.000 22.86566 ? 158 SER   A C   1 
ATOM   1206 O O   . SER   A 1 158 ? 2.49892   18.25548 -33.65656 1.000 21.40454 ? 158 SER   A O   1 
ATOM   1207 C CB  . SER   A 1 158 ? 4.93412   16.93482 -34.50673 1.000 23.72204 ? 158 SER   A CB  1 
ATOM   1208 O OG  . SER   A 1 158 ? 6.11121   16.58972 -35.21905 1.000 30.51340 ? 158 SER   A OG  1 
ATOM   1209 N N   . PHE   A 1 159 ? 1.44908   17.19000 -35.34873 1.000 20.37008 ? 159 PHE   A N   1 
ATOM   1210 C CA  . PHE   A 1 159 ? 0.13252   17.26046 -34.73110 1.000 20.44375 ? 159 PHE   A CA  1 
ATOM   1211 C C   . PHE   A 1 159 ? 0.01332   16.12284 -33.73061 1.000 18.81657 ? 159 PHE   A C   1 
ATOM   1212 O O   . PHE   A 1 159 ? 0.34103   14.97984 -34.05154 1.000 23.77999 ? 159 PHE   A O   1 
ATOM   1213 C CB  . PHE   A 1 159 ? -0.96998  17.13305 -35.79261 1.000 18.71411 ? 159 PHE   A CB  1 
ATOM   1214 C CG  . PHE   A 1 159 ? -0.98545  18.24446 -36.82963 1.000 20.95647 ? 159 PHE   A CG  1 
ATOM   1215 C CD1 . PHE   A 1 159 ? -1.59859  19.45179 -36.55138 1.000 18.62276 ? 159 PHE   A CD1 1 
ATOM   1216 C CD2 . PHE   A 1 159 ? -0.43780  18.05691 -38.09629 1.000 18.90599 ? 159 PHE   A CD2 1 
ATOM   1217 C CE1 . PHE   A 1 159 ? -1.66804  20.46080 -37.50086 1.000 18.12124 ? 159 PHE   A CE1 1 
ATOM   1218 C CE2 . PHE   A 1 159 ? -0.50273  19.05080 -39.04645 1.000 18.40403 ? 159 PHE   A CE2 1 
ATOM   1219 C CZ  . PHE   A 1 159 ? -1.10565  20.26360 -38.75778 1.000 19.79323 ? 159 PHE   A CZ  1 
ATOM   1220 N N   . CYS   A 1 160 ? -0.48347  16.41869 -32.52514 1.000 17.43301 ? 160 CYS   A N   1 
ATOM   1221 C CA  . CYS   A 1 160 ? -0.57399  15.40337 -31.49804 1.000 19.97748 ? 160 CYS   A CA  1 
ATOM   1222 C C   . CYS   A 1 160 ? -1.92110  15.31772 -30.78923 1.000 21.06936 ? 160 CYS   A C   1 
ATOM   1223 O O   . CYS   A 1 160 ? -2.12300  14.38001 -30.00430 1.000 20.96151 ? 160 CYS   A O   1 
ATOM   1224 C CB  . CYS   A 1 160 ? 0.54076   15.60619 -30.45337 1.000 22.98137 ? 160 CYS   A CB  1 
ATOM   1225 S SG  . CYS   A 1 160 ? 0.46747   17.21237 -29.57335 1.000 24.12460 ? 160 CYS   A SG  1 
ATOM   1226 N N   . TYR   A 1 161 ? -2.84333  16.23835 -31.03418 1.000 18.46478 ? 161 TYR   A N   1 
ATOM   1227 C CA  . TYR   A 1 161 ? -4.05892  16.29001 -30.24044 1.000 17.89352 ? 161 TYR   A CA  1 
ATOM   1228 C C   . TYR   A 1 161 ? -5.20148  16.79275 -31.10322 1.000 17.12209 ? 161 TYR   A C   1 
ATOM   1229 O O   . TYR   A 1 161 ? -5.01408  17.67865 -31.94211 1.000 19.03859 ? 161 TYR   A O   1 
ATOM   1230 C CB  . TYR   A 1 161 ? -3.89003  17.21281 -29.02971 1.000 17.73196 ? 161 TYR   A CB  1 
ATOM   1231 C CG  . TYR   A 1 161 ? -5.12850  17.34219 -28.17434 1.000 17.01265 ? 161 TYR   A CG  1 
ATOM   1232 C CD1 . TYR   A 1 161 ? -5.39209  16.43586 -27.16520 1.000 21.60901 ? 161 TYR   A CD1 1 
ATOM   1233 C CD2 . TYR   A 1 161 ? -6.00799  18.40209 -28.35850 1.000 21.16476 ? 161 TYR   A CD2 1 
ATOM   1234 C CE1 . TYR   A 1 161 ? -6.52188  16.57126 -26.37522 1.000 22.96511 ? 161 TYR   A CE1 1 
ATOM   1235 C CE2 . TYR   A 1 161 ? -7.15435  18.56143 -27.56039 1.000 18.41062 ? 161 TYR   A CE2 1 
ATOM   1236 C CZ  . TYR   A 1 161 ? -7.39564  17.64104 -26.57865 1.000 21.35321 ? 161 TYR   A CZ  1 
ATOM   1237 O OH  . TYR   A 1 161 ? -8.51900  17.77616 -25.79002 1.000 19.21134 ? 161 TYR   A OH  1 
ATOM   1238 N N   . MET   A 1 162 ? -6.38385  16.23052 -30.88921 1.000 18.04048 ? 162 MET   A N   1 
ATOM   1239 C CA  . MET   A 1 162 ? -7.59585  16.76538 -31.49689 1.000 18.13808 ? 162 MET   A CA  1 
ATOM   1240 C C   . MET   A 1 162 ? -8.65221  16.78150 -30.41957 1.000 15.84771 ? 162 MET   A C   1 
ATOM   1241 O O   . MET   A 1 162 ? -8.81703  15.78926 -29.70020 1.000 17.99810 ? 162 MET   A O   1 
ATOM   1242 C CB  . MET   A 1 162 ? -8.08045  15.95764 -32.70147 1.000 22.16338 ? 162 MET   A CB  1 
ATOM   1243 C CG  . MET   A 1 162 ? -9.25817  16.62398 -33.38133 1.000 19.24548 ? 162 MET   A CG  1 
ATOM   1244 S SD  . MET   A 1 162 ? -9.88687  15.83872 -34.89264 1.000 27.23294 ? 162 MET   A SD  1 
ATOM   1245 C CE  . MET   A 1 162 ? -9.26540  17.03467 -36.06526 1.000 23.69611 ? 162 MET   A CE  1 
ATOM   1246 N N   . HIS   A 1 163 ? -9.36152  17.90016 -30.29520 1.000 18.78996 ? 163 HIS   A N   1 
ATOM   1247 C CA  . HIS   A 1 163 ? -10.22577 18.06544 -29.13463 1.000 18.81962 ? 163 HIS   A CA  1 
ATOM   1248 C C   . HIS   A 1 163 ? -11.59179 17.40416 -29.32030 1.000 20.13271 ? 163 HIS   A C   1 
ATOM   1249 O O   . HIS   A 1 163 ? -12.23765 17.58679 -30.34833 1.000 18.83880 ? 163 HIS   A O   1 
ATOM   1250 C CB  . HIS   A 1 163 ? -10.42429 19.54339 -28.82521 1.000 22.14708 ? 163 HIS   A CB  1 
ATOM   1251 C CG  . HIS   A 1 163 ? -11.24103 19.74997 -27.59858 1.000 17.57782 ? 163 HIS   A CG  1 
ATOM   1252 N ND1 . HIS   A 1 163 ? -10.90961 19.14437 -26.40573 1.000 20.42251 ? 163 HIS   A ND1 1 
ATOM   1253 C CD2 . HIS   A 1 163 ? -12.40790 20.40394 -27.38715 1.000 19.74855 ? 163 HIS   A CD2 1 
ATOM   1254 C CE1 . HIS   A 1 163 ? -11.82382 19.44245 -25.49341 1.000 17.64241 ? 163 HIS   A CE1 1 
ATOM   1255 N NE2 . HIS   A 1 163 ? -12.73990 20.20854 -26.05945 1.000 19.02865 ? 163 HIS   A NE2 1 
ATOM   1256 N N   . HIS   A 1 164 ? -12.06358 16.67436 -28.27907 1.000 17.57076 ? 164 HIS   A N   1 
ATOM   1257 C CA  . HIS   A 1 164 ? -13.37978 16.02932 -28.32490 1.000 22.83153 ? 164 HIS   A CA  1 
ATOM   1258 C C   . HIS   A 1 164 ? -14.33386 16.38788 -27.18454 1.000 20.91644 ? 164 HIS   A C   1 
ATOM   1259 O O   . HIS   A 1 164 ? -15.54015 16.40892 -27.41924 1.000 26.21762 ? 164 HIS   A O   1 
ATOM   1260 C CB  . HIS   A 1 164 ? -13.23734 14.49925 -28.33395 1.000 21.18704 ? 164 HIS   A CB  1 
ATOM   1261 C CG  . HIS   A 1 164 ? -12.63013 13.95959 -29.59548 1.000 22.59712 ? 164 HIS   A CG  1 
ATOM   1262 N ND1 . HIS   A 1 164 ? -13.34637 13.21080 -30.50702 1.000 23.21845 ? 164 HIS   A ND1 1 
ATOM   1263 C CD2 . HIS   A 1 164 ? -11.37163 14.04636 -30.08834 1.000 22.87150 ? 164 HIS   A CD2 1 
ATOM   1264 C CE1 . HIS   A 1 164 ? -12.55667 12.86558 -31.50861 1.000 18.86782 ? 164 HIS   A CE1 1 
ATOM   1265 N NE2 . HIS   A 1 164 ? -11.35322 13.36029 -31.28164 1.000 23.52601 ? 164 HIS   A NE2 1 
ATOM   1266 N N   . MET   A 1 165 ? -13.86296 16.65339 -25.96611 1.000 20.02589 ? 165 MET   A N   1 
ATOM   1267 C CA  . MET   A 1 165 ? -14.86510 16.71748 -24.90856 1.000 22.90534 ? 165 MET   A CA  1 
ATOM   1268 C C   . MET   A 1 165 ? -14.32998 17.39623 -23.65737 1.000 22.38695 ? 165 MET   A C   1 
ATOM   1269 O O   . MET   A 1 165 ? -13.11862 17.51023 -23.45814 1.000 19.57850 ? 165 MET   A O   1 
ATOM   1270 C CB  . MET   A 1 165 ? -15.35806 15.30885 -24.58616 1.000 27.83183 ? 165 MET   A CB  1 
ATOM   1271 C CG  . MET   A 1 165 ? -14.33161 14.43642 -23.92462 1.000 26.57363 ? 165 MET   A CG  1 
ATOM   1272 S SD  . MET   A 1 165 ? -15.08791 12.84419 -23.57303 1.000 44.99814 ? 165 MET   A SD  1 
ATOM   1273 C CE  . MET   A 1 165 ? -16.32083 13.32091 -22.34675 1.000 39.17197 ? 165 MET   A CE  1 
ATOM   1274 N N   . GLU   A 1 166 ? -15.26368 17.80475 -22.79460 1.000 18.98464 ? 166 GLU   A N   1 
ATOM   1275 C CA  . GLU   A 1 166 ? -14.96010 18.30788 -21.46005 1.000 21.77621 ? 166 GLU   A CA  1 
ATOM   1276 C C   . GLU   A 1 166 ? -15.47715 17.33720 -20.40282 1.000 26.12144 ? 166 GLU   A C   1 
ATOM   1277 O O   . GLU   A 1 166 ? -16.54208 16.73935 -20.56911 1.000 28.77714 ? 166 GLU   A O   1 
ATOM   1278 C CB  . GLU   A 1 166 ? -15.59800 19.68158 -21.24231 1.000 24.49533 ? 166 GLU   A CB  1 
ATOM   1279 C CG  . GLU   A 1 166 ? -15.19380 20.35034 -19.92845 1.000 29.97068 ? 166 GLU   A CG  1 
ATOM   1280 C CD  . GLU   A 1 166 ? -15.60004 21.82513 -19.84487 1.000 31.82060 ? 166 GLU   A CD  1 
ATOM   1281 O OE1 . GLU   A 1 166 ? -15.34564 22.59794 -20.80110 1.000 32.21185 ? 166 GLU   A OE1 1 
ATOM   1282 O OE2 . GLU   A 1 166 ? -16.13631 22.22146 -18.79303 1.000 34.09027 ? 166 GLU   A OE2 1 
ATOM   1283 N N   . LEU   A 1 167 ? -14.73363 17.19828 -19.30489 1.000 25.62998 ? 167 LEU   A N   1 
ATOM   1284 C CA  . LEU   A 1 167 ? -15.05684 16.33477 -18.17535 1.000 26.72944 ? 167 LEU   A CA  1 
ATOM   1285 C C   . LEU   A 1 167 ? -15.70618 17.13455 -17.04666 1.000 29.72418 ? 167 LEU   A C   1 
ATOM   1286 O O   . LEU   A 1 167 ? -15.57258 18.35970 -16.98745 1.000 30.33294 ? 167 LEU   A O   1 
ATOM   1287 C CB  . LEU   A 1 167 ? -13.78471 15.65662 -17.65273 1.000 25.39735 ? 167 LEU   A CB  1 
ATOM   1288 C CG  . LEU   A 1 167 ? -12.92057 14.87543 -18.64503 1.000 31.09208 ? 167 LEU   A CG  1 
ATOM   1289 C CD1 . LEU   A 1 167 ? -11.74816 14.22117 -17.90849 1.000 34.23818 ? 167 LEU   A CD1 1 
ATOM   1290 C CD2 . LEU   A 1 167 ? -13.75098 13.85738 -19.38865 1.000 30.07982 ? 167 LEU   A CD2 1 
ATOM   1291 N N   . PRO   A 1 168 ? -16.41239 16.46926 -16.12163 1.000 30.28856 ? 168 PRO   A N   1 
ATOM   1292 C CA  . PRO   A 1 168 ? -17.11614 17.21056 -15.05907 1.000 31.79428 ? 168 PRO   A CA  1 
ATOM   1293 C C   . PRO   A 1 168 ? -16.22877 18.10165 -14.21004 1.000 33.10484 ? 168 PRO   A C   1 
ATOM   1294 O O   . PRO   A 1 168 ? -16.74200 19.04896 -13.60019 1.000 35.71257 ? 168 PRO   A O   1 
ATOM   1295 C CB  . PRO   A 1 168 ? -17.74331 16.09213 -14.20865 1.000 36.25251 ? 168 PRO   A CB  1 
ATOM   1296 C CG  . PRO   A 1 168 ? -17.90578 14.95005 -15.13531 1.000 31.28510 ? 168 PRO   A CG  1 
ATOM   1297 C CD  . PRO   A 1 168 ? -16.72706 15.02603 -16.07687 1.000 29.81759 ? 168 PRO   A CD  1 
ATOM   1298 N N   . THR   A 1 169 ? -14.92906 17.82603 -14.11805 1.000 28.81552 ? 169 THR   A N   1 
ATOM   1299 C CA  . THR   A 1 169 ? -14.04621 18.66410 -13.31613 1.000 32.09879 ? 169 THR   A CA  1 
ATOM   1300 C C   . THR   A 1 169 ? -13.62995 19.93643 -14.04024 1.000 33.01795 ? 169 THR   A C   1 
ATOM   1301 O O   . THR   A 1 169 ? -12.99583 20.80663 -13.43567 1.000 30.89168 ? 169 THR   A O   1 
ATOM   1302 C CB  . THR   A 1 169 ? -12.79872 17.86165 -12.89833 1.000 39.88028 ? 169 THR   A CB  1 
ATOM   1303 O OG1 . THR   A 1 169 ? -12.09664 17.41865 -14.06557 1.000 36.90606 ? 169 THR   A OG1 1 
ATOM   1304 C CG2 . THR   A 1 169 ? -13.18927 16.63079 -12.07564 1.000 35.74783 ? 169 THR   A CG2 1 
ATOM   1305 N N   . GLY   A 1 170 ? -13.96378 20.06379 -15.31639 1.000 30.31423 ? 170 GLY   A N   1 
ATOM   1306 C CA  . GLY   A 1 170 ? -13.61828 21.23563 -16.08730 1.000 28.82560 ? 170 GLY   A CA  1 
ATOM   1307 C C   . GLY   A 1 170 ? -12.42292 21.06677 -16.99889 1.000 28.52505 ? 170 GLY   A C   1 
ATOM   1308 O O   . GLY   A 1 170 ? -12.10367 22.00108 -17.73584 1.000 31.95371 ? 170 GLY   A O   1 
ATOM   1309 N N   . VAL   A 1 171 ? -11.75852 19.90458 -16.97997 1.000 30.91882 ? 171 VAL   A N   1 
ATOM   1310 C CA  . VAL   A 1 171 ? -10.57806 19.67286 -17.81345 1.000 28.33657 ? 171 VAL   A CA  1 
ATOM   1311 C C   . VAL   A 1 171 ? -11.03579 19.00319 -19.09870 1.000 23.86851 ? 171 VAL   A C   1 
ATOM   1312 O O   . VAL   A 1 171 ? -12.22590 18.73033 -19.26660 1.000 24.15496 ? 171 VAL   A O   1 
ATOM   1313 C CB  . VAL   A 1 171 ? -9.50485  18.84306 -17.07954 1.000 26.12168 ? 171 VAL   A CB  1 
ATOM   1314 C CG1 . VAL   A 1 171 ? -9.03847  19.58789 -15.83497 1.000 30.82928 ? 171 VAL   A CG1 1 
ATOM   1315 C CG2 . VAL   A 1 171 ? -10.04076 17.49737 -16.69801 1.000 29.28994 ? 171 VAL   A CG2 1 
ATOM   1316 N N   . HIS   A 1 172 ? -10.10652 18.75035 -20.02504 1.000 21.80174 ? 172 HIS   A N   1 
ATOM   1317 C CA  . HIS   A 1 172 ? -10.46260 18.41852 -21.39991 1.000 20.45951 ? 172 HIS   A CA  1 
ATOM   1318 C C   . HIS   A 1 172 ? -9.78313  17.13726 -21.85405 1.000 21.72427 ? 172 HIS   A C   1 
ATOM   1319 O O   . HIS   A 1 172 ? -8.73099  16.75671 -21.33273 1.000 21.73085 ? 172 HIS   A O   1 
ATOM   1320 C CB  . HIS   A 1 172 ? -10.12552 19.58343 -22.31296 1.000 20.46375 ? 172 HIS   A CB  1 
ATOM   1321 C CG  . HIS   A 1 172 ? -10.90462 20.81075 -21.97077 1.000 24.01861 ? 172 HIS   A CG  1 
ATOM   1322 N ND1 . HIS   A 1 172 ? -10.36355 21.87114 -21.27311 1.000 21.77860 ? 172 HIS   A ND1 1 
ATOM   1323 C CD2 . HIS   A 1 172 ? -12.20777 21.11912 -22.18057 1.000 22.78435 ? 172 HIS   A CD2 1 
ATOM   1324 C CE1 . HIS   A 1 172 ? -11.30022 22.78593 -21.07707 1.000 22.46864 ? 172 HIS   A CE1 1 
ATOM   1325 N NE2 . HIS   A 1 172 ? -12.42968 22.35003 -21.61092 1.000 23.89584 ? 172 HIS   A NE2 1 
ATOM   1326 N N   . ALA   A 1 173 ? -10.43342 16.45149 -22.79727 1.000 21.45727 ? 173 ALA   A N   1 
ATOM   1327 C CA  . ALA   A 1 173 ? -9.97905  15.15059 -23.27182 1.000 20.34623 ? 173 ALA   A CA  1 
ATOM   1328 C C   . ALA   A 1 173 ? -10.12196 15.09177 -24.78162 1.000 20.83629 ? 173 ALA   A C   1 
ATOM   1329 O O   . ALA   A 1 173 ? -11.02581 15.70908 -25.36383 1.000 20.01683 ? 173 ALA   A O   1 
ATOM   1330 C CB  . ALA   A 1 173 ? -10.75114 14.00555 -22.60736 1.000 26.47816 ? 173 ALA   A CB  1 
ATOM   1331 N N   . GLY   A 1 174 ? -9.21583  14.35704 -25.41694 1.000 17.79209 ? 174 GLY   A N   1 
ATOM   1332 C CA  . GLY   A 1 174 ? -9.22138  14.27517 -26.86237 1.000 16.25373 ? 174 GLY   A CA  1 
ATOM   1333 C C   . GLY   A 1 174 ? -8.37576  13.10974 -27.32638 1.000 21.75032 ? 174 GLY   A C   1 
ATOM   1334 O O   . GLY   A 1 174 ? -7.94370  12.28070 -26.52636 1.000 22.24766 ? 174 GLY   A O   1 
ATOM   1335 N N   . THR   A 1 175 ? -8.11533  13.07094 -28.63296 1.000 21.81692 ? 175 THR   A N   1 
ATOM   1336 C CA  . THR   A 1 175 ? -7.45442  11.94269 -29.27954 1.000 21.45523 ? 175 THR   A CA  1 
ATOM   1337 C C   . THR   A 1 175 ? -6.15462  12.38246 -29.94793 1.000 24.56687 ? 175 THR   A C   1 
ATOM   1338 O O   . THR   A 1 175 ? -5.90235  13.57511 -30.14759 1.000 22.31278 ? 175 THR   A O   1 
ATOM   1339 C CB  . THR   A 1 175 ? -8.38183  11.32020 -30.33870 1.000 19.82475 ? 175 THR   A CB  1 
ATOM   1340 O OG1 . THR   A 1 175 ? -8.58412  12.26422 -31.39809 1.000 21.68697 ? 175 THR   A OG1 1 
ATOM   1341 C CG2 . THR   A 1 175 ? -9.72490  10.93016 -29.73626 1.000 17.09754 ? 175 THR   A CG2 1 
ATOM   1342 N N   . ASP   A 1 176 ? -5.32275  11.40337 -30.32993 1.000 22.49976 ? 176 ASP   A N   1 
ATOM   1343 C CA  . ASP   A 1 176 ? -4.29775  11.70623 -31.32764 1.000 21.64490 ? 176 ASP   A CA  1 
ATOM   1344 C C   . ASP   A 1 176 ? -4.96101  11.81542 -32.70403 1.000 23.54600 ? 176 ASP   A C   1 
ATOM   1345 O O   . ASP   A 1 176 ? -6.18036  11.68810 -32.84086 1.000 25.23362 ? 176 ASP   A O   1 
ATOM   1346 C CB  . ASP   A 1 176 ? -3.17569  10.66527 -31.29783 1.000 24.66514 ? 176 ASP   A CB  1 
ATOM   1347 C CG  . ASP   A 1 176 ? -3.64496  9.24132  -31.60291 1.000 23.45404 ? 176 ASP   A CG  1 
ATOM   1348 O OD1 . ASP   A 1 176 ? -4.64267  9.05495  -32.30980 1.000 26.33740 ? 176 ASP   A OD1 1 
ATOM   1349 O OD2 . ASP   A 1 176 ? -2.98291  8.29384  -31.11353 1.000 24.74661 ? 176 ASP   A OD2 1 
ATOM   1350 N N   . LEU   A 1 177 ? -4.15975  12.04349 -33.74444 1.000 22.35434 ? 177 LEU   A N   1 
ATOM   1351 C CA  . LEU   A 1 177 ? -4.71652  12.22582 -35.08800 1.000 22.22981 ? 177 LEU   A CA  1 
ATOM   1352 C C   . LEU   A 1 177 ? -5.03527  10.90451 -35.77995 1.000 27.50697 ? 177 LEU   A C   1 
ATOM   1353 O O   . LEU   A 1 177 ? -5.60480  10.91809 -36.87721 1.000 27.42177 ? 177 LEU   A O   1 
ATOM   1354 C CB  . LEU   A 1 177 ? -3.77262  13.08562 -35.95064 1.000 25.53652 ? 177 LEU   A CB  1 
ATOM   1355 C CG  . LEU   A 1 177 ? -4.00079  14.61156 -35.92843 1.000 26.53064 ? 177 LEU   A CG  1 
ATOM   1356 C CD1 . LEU   A 1 177 ? -5.32599  14.99990 -36.52919 1.000 23.71654 ? 177 LEU   A CD1 1 
ATOM   1357 C CD2 . LEU   A 1 177 ? -3.90632  15.14577 -34.51868 1.000 25.84831 ? 177 LEU   A CD2 1 
ATOM   1358 N N   . GLU   A 1 178 ? -4.71563  9.77505  -35.15090 1.000 26.00031 ? 178 GLU   A N   1 
ATOM   1359 C CA  . GLU   A 1 178 ? -5.24882  8.47761  -35.54370 1.000 26.62648 ? 178 GLU   A CA  1 
ATOM   1360 C C   . GLU   A 1 178 ? -6.58042  8.17284  -34.85836 1.000 23.47223 ? 178 GLU   A C   1 
ATOM   1361 O O   . GLU   A 1 178 ? -7.12269  7.08255  -35.03417 1.000 29.06133 ? 178 GLU   A O   1 
ATOM   1362 C CB  . GLU   A 1 178 ? -4.23467  7.37532  -35.22260 1.000 29.72544 ? 178 GLU   A CB  1 
ATOM   1363 C CG  . GLU   A 1 178 ? -3.21456  7.21650  -36.32803 1.000 35.00678 ? 178 GLU   A CG  1 
ATOM   1364 C CD  . GLU   A 1 178 ? -2.03029  6.36173  -35.92551 1.000 48.47133 ? 178 GLU   A CD  1 
ATOM   1365 O OE1 . GLU   A 1 178 ? -1.79196  6.17242  -34.70721 1.000 45.71347 ? 178 GLU   A OE1 1 
ATOM   1366 O OE2 . GLU   A 1 178 ? -1.34106  5.86978  -36.84556 1.000 46.90688 ? 178 GLU   A OE2 1 
ATOM   1367 N N   . GLY   A 1 179 ? -7.10694  9.10450  -34.06003 1.000 21.54021 ? 179 GLY   A N   1 
ATOM   1368 C CA  . GLY   A 1 179 ? -8.40545  8.92398  -33.43891 1.000 19.33398 ? 179 GLY   A CA  1 
ATOM   1369 C C   . GLY   A 1 179 ? -8.43082  8.13985  -32.14816 1.000 22.40079 ? 179 GLY   A C   1 
ATOM   1370 O O   . GLY   A 1 179 ? -9.52583  7.81538  -31.65980 1.000 23.63102 ? 179 GLY   A O   1 
ATOM   1371 N N   . ASN   A 1 180 ? -7.27545  7.82284  -31.57259 1.000 20.63898 ? 180 ASN   A N   1 
ATOM   1372 C CA  . ASN   A 1 180 ? -7.21093  7.10995  -30.30137 1.000 23.11387 ? 180 ASN   A CA  1 
ATOM   1373 C C   . ASN   A 1 180 ? -7.15897  8.09356  -29.14634 1.000 23.50621 ? 180 ASN   A C   1 
ATOM   1374 O O   . ASN   A 1 180 ? -6.28722  8.96146  -29.11402 1.000 22.14439 ? 180 ASN   A O   1 
ATOM   1375 C CB  . ASN   A 1 180 ? -5.97921  6.21794  -30.24750 1.000 21.02082 ? 180 ASN   A CB  1 
ATOM   1376 C CG  . ASN   A 1 180 ? -6.08203  5.05249  -31.20006 1.000 31.20257 ? 180 ASN   A CG  1 
ATOM   1377 O OD1 . ASN   A 1 180 ? -7.05342  4.29455  -31.15465 1.000 28.94555 ? 180 ASN   A OD1 1 
ATOM   1378 N ND2 . ASN   A 1 180 ? -5.10837  4.92009  -32.08544 1.000 32.42874 ? 180 ASN   A ND2 1 
ATOM   1379 N N   . PHE   A 1 181 ? -8.06683  7.93252  -28.19357 1.000 22.42559 ? 181 PHE   A N   1 
ATOM   1380 C CA  . PHE   A 1 181 ? -8.10405  8.83246  -27.05285 1.000 20.90908 ? 181 PHE   A CA  1 
ATOM   1381 C C   . PHE   A 1 181 ? -6.82315  8.74305  -26.23340 1.000 23.66072 ? 181 PHE   A C   1 
ATOM   1382 O O   . PHE   A 1 181 ? -6.23095  7.67060  -26.06803 1.000 20.78959 ? 181 PHE   A O   1 
ATOM   1383 C CB  . PHE   A 1 181 ? -9.29958  8.49541  -26.16122 1.000 24.47262 ? 181 PHE   A CB  1 
ATOM   1384 C CG  . PHE   A 1 181 ? -10.46591 9.39613  -26.36837 1.000 25.87892 ? 181 PHE   A CG  1 
ATOM   1385 C CD1 . PHE   A 1 181 ? -10.52147 10.63529 -25.72919 1.000 20.77145 ? 181 PHE   A CD1 1 
ATOM   1386 C CD2 . PHE   A 1 181 ? -11.50864 9.01318  -27.20379 1.000 21.74556 ? 181 PHE   A CD2 1 
ATOM   1387 C CE1 . PHE   A 1 181 ? -11.58794 11.49480 -25.91766 1.000 22.60817 ? 181 PHE   A CE1 1 
ATOM   1388 C CE2 . PHE   A 1 181 ? -12.59402 9.86696  -27.39205 1.000 26.44884 ? 181 PHE   A CE2 1 
ATOM   1389 C CZ  . PHE   A 1 181 ? -12.62541 11.12000 -26.73913 1.000 28.93930 ? 181 PHE   A CZ  1 
ATOM   1390 N N   . TYR   A 1 182 ? -6.41112  9.87904  -25.68955 1.000 22.77156 ? 182 TYR   A N   1 
ATOM   1391 C CA  . TYR   A 1 182 ? -5.50180  9.86096  -24.56067 1.000 22.97409 ? 182 TYR   A CA  1 
ATOM   1392 C C   . TYR   A 1 182 ? -6.31493  9.54184  -23.30574 1.000 22.39857 ? 182 TYR   A C   1 
ATOM   1393 O O   . TYR   A 1 182 ? -7.35022  10.16691 -23.05953 1.000 23.09934 ? 182 TYR   A O   1 
ATOM   1394 C CB  . TYR   A 1 182 ? -4.81663  11.21878 -24.44122 1.000 22.82944 ? 182 TYR   A CB  1 
ATOM   1395 C CG  . TYR   A 1 182 ? -3.81987  11.52575 -25.55157 1.000 23.21147 ? 182 TYR   A CG  1 
ATOM   1396 C CD1 . TYR   A 1 182 ? -2.52369  11.03150 -25.50263 1.000 24.05180 ? 182 TYR   A CD1 1 
ATOM   1397 C CD2 . TYR   A 1 182 ? -4.17461  12.33068 -26.63334 1.000 20.04908 ? 182 TYR   A CD2 1 
ATOM   1398 C CE1 . TYR   A 1 182 ? -1.59486  11.33482 -26.50441 1.000 23.27806 ? 182 TYR   A CE1 1 
ATOM   1399 C CE2 . TYR   A 1 182 ? -3.24841  12.64481 -27.64243 1.000 18.99609 ? 182 TYR   A CE2 1 
ATOM   1400 C CZ  . TYR   A 1 182 ? -1.96387  12.13287 -27.56232 1.000 21.91444 ? 182 TYR   A CZ  1 
ATOM   1401 O OH  . TYR   A 1 182 ? -1.04290  12.42500 -28.53436 1.000 20.95904 ? 182 TYR   A OH  1 
ATOM   1402 N N   . GLY   A 1 183 ? -5.88954  8.53710  -22.54028 1.000 24.27949 ? 183 GLY   A N   1 
ATOM   1403 C CA  . GLY   A 1 183 ? -6.59158  8.17315  -21.32588 1.000 26.23037 ? 183 GLY   A CA  1 
ATOM   1404 C C   . GLY   A 1 183 ? -7.80032  7.28745  -21.56984 1.000 28.81299 ? 183 GLY   A C   1 
ATOM   1405 O O   . GLY   A 1 183 ? -8.08489  6.89132  -22.70421 1.000 30.05679 ? 183 GLY   A O   1 
ATOM   1406 N N   . PRO   A 1 184 ? -8.55787  6.97236  -20.48981 1.000 28.65123 ? 184 PRO   A N   1 
ATOM   1407 C CA  . PRO   A 1 184 ? -9.64183  5.98672  -20.59448 1.000 28.90721 ? 184 PRO   A CA  1 
ATOM   1408 C C   . PRO   A 1 184 ? -10.99450 6.61437  -20.89396 1.000 34.87508 ? 184 PRO   A C   1 
ATOM   1409 O O   . PRO   A 1 184 ? -11.98562 6.27503  -20.24101 1.000 40.85745 ? 184 PRO   A O   1 
ATOM   1410 C CB  . PRO   A 1 184 ? -9.65163  5.35616  -19.20012 1.000 28.80895 ? 184 PRO   A CB  1 
ATOM   1411 C CG  . PRO   A 1 184 ? -9.35170  6.52088  -18.31490 1.000 32.93111 ? 184 PRO   A CG  1 
ATOM   1412 C CD  . PRO   A 1 184 ? -8.38178  7.41966  -19.09704 1.000 33.25870 ? 184 PRO   A CD  1 
ATOM   1413 N N   . PHE   A 1 185 ? -11.05745 7.54441  -21.83978 1.000 30.50738 ? 185 PHE   A N   1 
ATOM   1414 C CA  . PHE   A 1 185 ? -12.28299 8.28308  -22.12014 1.000 26.40104 ? 185 PHE   A CA  1 
ATOM   1415 C C   . PHE   A 1 185 ? -12.89666 7.78977  -23.42327 1.000 27.92748 ? 185 PHE   A C   1 
ATOM   1416 O O   . PHE   A 1 185 ? -12.21379 7.22606  -24.28384 1.000 27.73239 ? 185 PHE   A O   1 
ATOM   1417 C CB  . PHE   A 1 185 ? -11.98898 9.78339  -22.18326 1.000 27.93952 ? 185 PHE   A CB  1 
ATOM   1418 C CG  . PHE   A 1 185 ? -11.27293 10.28573 -20.97096 1.000 27.85927 ? 185 PHE   A CG  1 
ATOM   1419 C CD1 . PHE   A 1 185 ? -11.86894 10.19759 -19.72419 1.000 26.93683 ? 185 PHE   A CD1 1 
ATOM   1420 C CD2 . PHE   A 1 185 ? -9.97151  10.76683 -21.06347 1.000 23.82200 ? 185 PHE   A CD2 1 
ATOM   1421 C CE1 . PHE   A 1 185 ? -11.19866 10.62755 -18.58355 1.000 33.42258 ? 185 PHE   A CE1 1 
ATOM   1422 C CE2 . PHE   A 1 185 ? -9.29630  11.18474 -19.92900 1.000 26.14781 ? 185 PHE   A CE2 1 
ATOM   1423 C CZ  . PHE   A 1 185 ? -9.92153  11.11930 -18.68545 1.000 27.52326 ? 185 PHE   A CZ  1 
ATOM   1424 N N   . VAL   A 1 186 ? -14.20840 7.98404  -23.54768 1.000 26.50426 ? 186 VAL   A N   1 
ATOM   1425 C CA  . VAL   A 1 186 ? -14.93184 7.68171  -24.77732 1.000 26.65014 ? 186 VAL   A CA  1 
ATOM   1426 C C   . VAL   A 1 186 ? -15.67964 8.93396  -25.22637 1.000 25.26602 ? 186 VAL   A C   1 
ATOM   1427 O O   . VAL   A 1 186 ? -15.98021 9.82671  -24.42568 1.000 24.67469 ? 186 VAL   A O   1 
ATOM   1428 C CB  . VAL   A 1 186 ? -15.90396 6.50053  -24.58605 1.000 25.25841 ? 186 VAL   A CB  1 
ATOM   1429 C CG1 . VAL   A 1 186 ? -15.12263 5.20748  -24.33857 1.000 28.10219 ? 186 VAL   A CG1 1 
ATOM   1430 C CG2 . VAL   A 1 186 ? -16.86288 6.78605  -23.43181 1.000 29.50772 ? 186 VAL   A CG2 1 
ATOM   1431 N N   . ASP   A 1 187 ? -15.98215 8.99897  -26.53121 1.000 24.36939 ? 187 ASP   A N   1 
ATOM   1432 C CA  . ASP   A 1 187 ? -16.70415 10.15106 -27.08302 1.000 21.52091 ? 187 ASP   A CA  1 
ATOM   1433 C C   . ASP   A 1 187 ? -18.21661 9.91986  -27.01361 1.000 26.49011 ? 187 ASP   A C   1 
ATOM   1434 O O   . ASP   A 1 187 ? -18.90549 9.65389  -28.00622 1.000 25.83557 ? 187 ASP   A O   1 
ATOM   1435 C CB  . ASP   A 1 187 ? -16.24103 10.49135 -28.50547 1.000 26.08098 ? 187 ASP   A CB  1 
ATOM   1436 C CG  . ASP   A 1 187 ? -16.20210 9.28078  -29.45638 1.000 24.32820 ? 187 ASP   A CG  1 
ATOM   1437 O OD1 . ASP   A 1 187 ? -16.22213 8.11868  -28.99250 1.000 27.16948 ? 187 ASP   A OD1 1 
ATOM   1438 O OD2 . ASP   A 1 187 ? -16.13213 9.51792  -30.68623 1.000 25.40567 ? 187 ASP   A OD2 1 
ATOM   1439 N N   . ARG   A 1 188 ? -18.75260 10.10574 -25.81125 1.000 24.78310 ? 188 ARG   A N   1 
ATOM   1440 C CA  . ARG   A 1 188 ? -20.19663 10.14553 -25.64360 1.000 25.77263 ? 188 ARG   A CA  1 
ATOM   1441 C C   . ARG   A 1 188 ? -20.52151 11.08747 -24.49826 1.000 25.37356 ? 188 ARG   A C   1 
ATOM   1442 O O   . ARG   A 1 188 ? -19.67360 11.39032 -23.66091 1.000 25.31461 ? 188 ARG   A O   1 
ATOM   1443 C CB  . ARG   A 1 188 ? -20.76722 8.74278  -25.41061 1.000 33.80495 ? 188 ARG   A CB  1 
ATOM   1444 C CG  . ARG   A 1 188 ? -20.16583 8.01216  -24.24298 1.000 35.29731 ? 188 ARG   A CG  1 
ATOM   1445 C CD  . ARG   A 1 188 ? -20.84097 6.66894  -24.04559 1.000 34.13900 ? 188 ARG   A CD  1 
ATOM   1446 N NE  . ARG   A 1 188 ? -22.20362 6.86999  -23.56334 1.000 43.78708 ? 188 ARG   A NE  1 
ATOM   1447 C CZ  . ARG   A 1 188 ? -22.84546 6.03698  -22.75567 1.000 44.95729 ? 188 ARG   A CZ  1 
ATOM   1448 N NH1 . ARG   A 1 188 ? -22.25938 4.94259  -22.28696 1.000 39.24053 ? 188 ARG   A NH1 1 
ATOM   1449 N NH2 . ARG   A 1 188 ? -24.09853 6.31821  -22.39602 1.000 44.33750 ? 188 ARG   A NH2 1 
ATOM   1450 N N   . GLN   A 1 189 ? -21.76227 11.56652 -24.48969 1.000 28.13076 ? 189 GLN   A N   1 
ATOM   1451 C CA  . GLN   A 1 189 ? -22.23567 12.50489 -23.47834 1.000 24.83791 ? 189 GLN   A CA  1 
ATOM   1452 C C   . GLN   A 1 189 ? -22.63876 11.74626 -22.22152 1.000 27.11118 ? 189 GLN   A C   1 
ATOM   1453 O O   . GLN   A 1 189 ? -23.81433 11.51340 -21.94211 1.000 24.02744 ? 189 GLN   A O   1 
ATOM   1454 C CB  . GLN   A 1 189 ? -23.38885 13.32774 -24.01351 1.000 29.79439 ? 189 GLN   A CB  1 
ATOM   1455 C CG  . GLN   A 1 189 ? -23.74256 14.49547 -23.12585 1.000 27.68486 ? 189 GLN   A CG  1 
ATOM   1456 C CD  . GLN   A 1 189 ? -24.93477 15.26267 -23.65738 1.000 33.05556 ? 189 GLN   A CD  1 
ATOM   1457 O OE1 . GLN   A 1 189 ? -24.97841 15.60422 -24.85195 1.000 26.18784 ? 189 GLN   A OE1 1 
ATOM   1458 N NE2 . GLN   A 1 189 ? -25.92391 15.52714 -22.78500 1.000 24.42668 ? 189 GLN   A NE2 1 
ATOM   1459 N N   . THR   A 1 190 ? -21.63417 11.38257 -21.43783 1.000 26.31497 ? 190 THR   A N   1 
ATOM   1460 C CA  . THR   A 1 190 ? -21.85786 10.75197 -20.14836 1.000 26.75397 ? 190 THR   A CA  1 
ATOM   1461 C C   . THR   A 1 190 ? -20.78633 11.25500 -19.19327 1.000 29.98081 ? 190 THR   A C   1 
ATOM   1462 O O   . THR   A 1 190 ? -19.73505 11.73704 -19.61696 1.000 27.67158 ? 190 THR   A O   1 
ATOM   1463 C CB  . THR   A 1 190 ? -21.86638 9.21628  -20.27110 1.000 30.82021 ? 190 THR   A CB  1 
ATOM   1464 O OG1 . THR   A 1 190 ? -22.46958 8.64801  -19.10089 1.000 30.10182 ? 190 THR   A OG1 1 
ATOM   1465 C CG2 . THR   A 1 190 ? -20.46036 8.65977  -20.44587 1.000 30.76311 ? 190 THR   A CG2 1 
ATOM   1466 N N   . ALA   A 1 191 ? -21.07684 11.19028 -17.89760 1.000 28.10546 ? 191 ALA   A N   1 
ATOM   1467 C CA  . ALA   A 1 191 ? -20.11724 11.66655 -16.91328 1.000 31.51052 ? 191 ALA   A CA  1 
ATOM   1468 C C   . ALA   A 1 191 ? -18.93036 10.71452 -16.85005 1.000 29.37129 ? 191 ALA   A C   1 
ATOM   1469 O O   . ALA   A 1 191 ? -19.10261 9.50010  -16.73460 1.000 27.76346 ? 191 ALA   A O   1 
ATOM   1470 C CB  . ALA   A 1 191 ? -20.77752 11.79765 -15.54270 1.000 30.96863 ? 191 ALA   A CB  1 
ATOM   1471 N N   . GLN   A 1 192 ? -17.72145 11.26740 -16.94242 1.000 28.46170 ? 192 GLN   A N   1 
ATOM   1472 C CA  . GLN   A 1 192 ? -16.50135 10.48236 -16.94242 1.000 31.81208 ? 192 GLN   A CA  1 
ATOM   1473 C C   . GLN   A 1 192 ? -15.49261 11.14955 -16.02471 1.000 31.55494 ? 192 GLN   A C   1 
ATOM   1474 O O   . GLN   A 1 192 ? -15.23730 12.34754 -16.14961 1.000 34.47073 ? 192 GLN   A O   1 
ATOM   1475 C CB  . GLN   A 1 192 ? -15.94176 10.35111 -18.36063 1.000 30.02775 ? 192 GLN   A CB  1 
ATOM   1476 C CG  . GLN   A 1 192 ? -16.92858 9.69249  -19.32792 1.000 29.35255 ? 192 GLN   A CG  1 
ATOM   1477 C CD  . GLN   A 1 192 ? -16.39928 9.63482  -20.74252 1.000 33.04187 ? 192 GLN   A CD  1 
ATOM   1478 O OE1 . GLN   A 1 192 ? -15.31787 9.09539  -20.99391 1.000 26.35239 ? 192 GLN   A OE1 1 
ATOM   1479 N NE2 . GLN   A 1 192 ? -17.15155 10.20948 -21.67735 1.000 25.73960 ? 192 GLN   A NE2 1 
ATOM   1480 N N   . ALA   A 1 193 ? -14.90119 10.36849 -15.13613 1.000 32.45607 ? 193 ALA   A N   1 
ATOM   1481 C CA  . ALA   A 1 193 ? -13.98821 10.87817 -14.12048 1.000 38.38267 ? 193 ALA   A CA  1 
ATOM   1482 C C   . ALA   A 1 193 ? -12.54849 10.75085 -14.59031 1.000 39.14024 ? 193 ALA   A C   1 
ATOM   1483 O O   . ALA   A 1 193 ? -12.13520 9.68978  -15.07642 1.000 39.08072 ? 193 ALA   A O   1 
ATOM   1484 C CB  . ALA   A 1 193 ? -14.16109 10.12628 -12.79854 1.000 44.58558 ? 193 ALA   A CB  1 
ATOM   1485 N N   . ALA   A 1 194 ? -11.79368 11.83393 -14.43786 1.000 40.83990 ? 194 ALA   A N   1 
ATOM   1486 C CA  . ALA   A 1 194 ? -10.36312 11.79551 -14.68631 1.000 41.69197 ? 194 ALA   A CA  1 
ATOM   1487 C C   . ALA   A 1 194 ? -9.65986  11.05674 -13.55264 1.000 50.61243 ? 194 ALA   A C   1 
ATOM   1488 O O   . ALA   A 1 194 ? -10.06263 11.15941 -12.38936 1.000 50.84150 ? 194 ALA   A O   1 
ATOM   1489 C CB  . ALA   A 1 194 ? -9.82586  13.22065 -14.80695 1.000 39.23604 ? 194 ALA   A CB  1 
ATOM   1490 N N   . GLY   A 1 195 ? -8.61066  10.30429 -13.89160 1.000 45.19478 ? 195 GLY   A N   1 
ATOM   1491 C CA  . GLY   A 1 195 ? -7.78297  9.67342  -12.87627 1.000 43.22415 ? 195 GLY   A CA  1 
ATOM   1492 C C   . GLY   A 1 195 ? -7.23825  10.67870 -11.86144 1.000 42.98898 ? 195 GLY   A C   1 
ATOM   1493 O O   . GLY   A 1 195 ? -7.34799  11.89821 -12.00030 1.000 40.51801 ? 195 GLY   A O   1 
ATOM   1494 N N   . THR   A 1 196 ? -6.66007  10.14176 -10.78767 1.000 45.17267 ? 196 THR   A N   1 
ATOM   1495 C CA  . THR   A 1 196 ? -5.93970  10.98727 -9.84107  1.000 39.51687 ? 196 THR   A CA  1 
ATOM   1496 C C   . THR   A 1 196 ? -4.65539  11.49784 -10.49296 1.000 35.37885 ? 196 THR   A C   1 
ATOM   1497 O O   . THR   A 1 196 ? -3.87294  10.71812 -11.04195 1.000 40.76603 ? 196 THR   A O   1 
ATOM   1498 C CB  . THR   A 1 196 ? -5.62463  10.21498 -8.55383  1.000 45.15169 ? 196 THR   A CB  1 
ATOM   1499 O OG1 . THR   A 1 196 ? -5.07005  8.92971  -8.88062  1.000 47.29373 ? 196 THR   A OG1 1 
ATOM   1500 C CG2 . THR   A 1 196 ? -6.88410  10.03119 -7.69835  1.000 44.04360 ? 196 THR   A CG2 1 
ATOM   1501 N N   . ASP   A 1 197 ? -4.44203  12.80675 -10.44844 1.000 41.82624 ? 197 ASP   A N   1 
ATOM   1502 C CA  . ASP   A 1 197 ? -3.29809  13.39375 -11.13189 1.000 35.32205 ? 197 ASP   A CA  1 
ATOM   1503 C C   . ASP   A 1 197 ? -2.04388  13.35146 -10.24481 1.000 38.50700 ? 197 ASP   A C   1 
ATOM   1504 O O   . ASP   A 1 197 ? -2.09099  12.98433 -9.06998  1.000 37.02508 ? 197 ASP   A O   1 
ATOM   1505 C CB  . ASP   A 1 197 ? -3.62722  14.81932 -11.55969 1.000 29.72901 ? 197 ASP   A CB  1 
ATOM   1506 C CG  . ASP   A 1 197 ? -2.84670  15.25621 -12.79229 1.000 28.12882 ? 197 ASP   A CG  1 
ATOM   1507 O OD1 . ASP   A 1 197 ? -2.34889  14.38030 -13.55860 1.000 28.73709 ? 197 ASP   A OD1 1 
ATOM   1508 O OD2 . ASP   A 1 197 ? -2.73579  16.48505 -12.99747 1.000 28.89073 ? 197 ASP   A OD2 1 
ATOM   1509 N N   . THR   A 1 198 ? -0.90407  13.72177 -10.83780 1.000 32.19377 ? 198 THR   A N   1 
ATOM   1510 C CA  . THR   A 1 198 ? 0.39548   13.73124 -10.17020 1.000 29.70992 ? 198 THR   A CA  1 
ATOM   1511 C C   . THR   A 1 198 ? 1.17284   14.95227 -10.65265 1.000 25.88914 ? 198 THR   A C   1 
ATOM   1512 O O   . THR   A 1 198 ? 0.93587   15.44795 -11.75687 1.000 27.00840 ? 198 THR   A O   1 
ATOM   1513 C CB  . THR   A 1 198 ? 1.20957   12.45422 -10.47839 1.000 30.77780 ? 198 THR   A CB  1 
ATOM   1514 O OG1 . THR   A 1 198 ? 0.33008   11.33245 -10.62082 1.000 44.76701 ? 198 THR   A OG1 1 
ATOM   1515 C CG2 . THR   A 1 198 ? 2.21916   12.16658 -9.36602  1.000 34.45139 ? 198 THR   A CG2 1 
ATOM   1516 N N   . THR   A 1 199 ? 2.11718   15.43440 -9.83458  1.000 24.11643 ? 199 THR   A N   1 
ATOM   1517 C CA  . THR   A 1 199 ? 2.95984   16.55404 -10.26849 1.000 24.86566 ? 199 THR   A CA  1 
ATOM   1518 C C   . THR   A 1 199 ? 4.11857   16.07022 -11.13684 1.000 22.81096 ? 199 THR   A C   1 
ATOM   1519 O O   . THR   A 1 199 ? 4.78848   15.08295 -10.81727 1.000 21.76202 ? 199 THR   A O   1 
ATOM   1520 C CB  . THR   A 1 199 ? 3.47558   17.34213 -9.05819  1.000 27.48914 ? 199 THR   A CB  1 
ATOM   1521 O OG1 . THR   A 1 199 ? 2.36141   17.97405 -8.41702  1.000 24.37112 ? 199 THR   A OG1 1 
ATOM   1522 C CG2 . THR   A 1 199 ? 4.46872   18.43615 -9.49677  1.000 27.19951 ? 199 THR   A CG2 1 
ATOM   1523 N N   . ILE   A 1 200 ? 4.35719   16.76043 -12.25430 1.000 21.89057 ? 200 ILE   A N   1 
ATOM   1524 C CA  . ILE   A 1 200 ? 5.39148   16.34128 -13.20230 1.000 23.39641 ? 200 ILE   A CA  1 
ATOM   1525 C C   . ILE   A 1 200 ? 6.73467   16.87102 -12.69738 1.000 23.15668 ? 200 ILE   A C   1 
ATOM   1526 O O   . ILE   A 1 200 ? 7.12680   17.99080 -13.01213 1.000 19.65893 ? 200 ILE   A O   1 
ATOM   1527 C CB  . ILE   A 1 200 ? 5.09426   16.82196 -14.62655 1.000 20.24813 ? 200 ILE   A CB  1 
ATOM   1528 C CG1 . ILE   A 1 200 ? 3.69192   16.42874 -15.06155 1.000 22.19405 ? 200 ILE   A CG1 1 
ATOM   1529 C CG2 . ILE   A 1 200 ? 6.09330   16.24117 -15.61250 1.000 20.07370 ? 200 ILE   A CG2 1 
ATOM   1530 C CD1 . ILE   A 1 200 ? 3.22255   17.29591 -16.24490 1.000 21.39151 ? 200 ILE   A CD1 1 
ATOM   1531 N N   . THR   A 1 201 ? 7.48619   16.02253 -11.99772 1.000 18.59119 ? 201 THR   A N   1 
ATOM   1532 C CA  . THR   A 1 201 ? 8.70137   16.45211 -11.29825 1.000 18.53037 ? 201 THR   A CA  1 
ATOM   1533 C C   . THR   A 1 201 ? 9.75324   17.05133 -12.23189 1.000 19.00612 ? 201 THR   A C   1 
ATOM   1534 O O   . THR   A 1 201 ? 10.35160  18.08783 -11.92033 1.000 19.01846 ? 201 THR   A O   1 
ATOM   1535 C CB  . THR   A 1 201 ? 9.25888   15.25128 -10.54460 1.000 20.28207 ? 201 THR   A CB  1 
ATOM   1536 O OG1 . THR   A 1 201 ? 8.21404   14.75960 -9.70413  1.000 21.25289 ? 201 THR   A OG1 1 
ATOM   1537 C CG2 . THR   A 1 201 ? 10.50820  15.63603 -9.70001  1.000 22.07299 ? 201 THR   A CG2 1 
ATOM   1538 N N   . VAL   A 1 202 ? 10.02523  16.39700 -13.36089 1.000 19.12913 ? 202 VAL   A N   1 
ATOM   1539 C CA  . VAL   A 1 202 ? 11.09163  16.88556 -14.22539 1.000 16.81159 ? 202 VAL   A CA  1 
ATOM   1540 C C   . VAL   A 1 202 ? 10.74081  18.27421 -14.77783 1.000 18.56081 ? 202 VAL   A C   1 
ATOM   1541 O O   . VAL   A 1 202 ? 11.63960  19.08403 -15.03622 1.000 17.61563 ? 202 VAL   A O   1 
ATOM   1542 C CB  . VAL   A 1 202 ? 11.39406  15.87243 -15.35920 1.000 19.41846 ? 202 VAL   A CB  1 
ATOM   1543 C CG1 . VAL   A 1 202 ? 10.22350  15.75756 -16.32779 1.000 22.79322 ? 202 VAL   A CG1 1 
ATOM   1544 C CG2 . VAL   A 1 202 ? 12.67006  16.27793 -16.12328 1.000 19.32579 ? 202 VAL   A CG2 1 
ATOM   1545 N N   . ASN   A 1 203 ? 9.43821   18.57830 -14.95449 1.000 16.58216 ? 203 ASN   A N   1 
ATOM   1546 C CA  . ASN   A 1 203 ? 9.03743   19.90347 -15.41448 1.000 16.80902 ? 203 ASN   A CA  1 
ATOM   1547 C C   . ASN   A 1 203 ? 9.21594   20.95426 -14.32540 1.000 19.45613 ? 203 ASN   A C   1 
ATOM   1548 O O   . ASN   A 1 203 ? 9.61110   22.08357 -14.61134 1.000 14.79787 ? 203 ASN   A O   1 
ATOM   1549 C CB  . ASN   A 1 203 ? 7.58939   19.88931 -15.88675 1.000 18.93358 ? 203 ASN   A CB  1 
ATOM   1550 C CG  . ASN   A 1 203 ? 7.40929   19.16767 -17.23143 1.000 20.43874 ? 203 ASN   A CG  1 
ATOM   1551 O OD1 . ASN   A 1 203 ? 8.36105   18.62348 -17.80092 1.000 19.11010 ? 203 ASN   A OD1 1 
ATOM   1552 N ND2 . ASN   A 1 203 ? 6.18050   19.17055 -17.74229 1.000 18.32355 ? 203 ASN   A ND2 1 
ATOM   1553 N N   . VAL   A 1 204 ? 8.87981   20.62924 -13.07601 1.000 15.36528 ? 204 VAL   A N   1 
ATOM   1554 C CA  . VAL   A 1 204 ? 9.16938   21.56559 -11.98561 1.000 18.83909 ? 204 VAL   A CA  1 
ATOM   1555 C C   . VAL   A 1 204 ? 10.64635  21.94345 -11.97076 1.000 15.96882 ? 204 VAL   A C   1 
ATOM   1556 O O   . VAL   A 1 204 ? 11.01612  23.12455 -11.83432 1.000 16.59558 ? 204 VAL   A O   1 
ATOM   1557 C CB  . VAL   A 1 204 ? 8.74726   20.95910 -10.64019 1.000 21.02169 ? 204 VAL   A CB  1 
ATOM   1558 C CG1 . VAL   A 1 204 ? 9.11513   21.91509 -9.48014  1.000 19.06225 ? 204 VAL   A CG1 1 
ATOM   1559 C CG2 . VAL   A 1 204 ? 7.28477   20.63069 -10.65581 1.000 18.35756 ? 204 VAL   A CG2 1 
ATOM   1560 N N   . LEU   A 1 205 ? 11.52158  20.94641 -12.10640 1.000 15.22156 ? 205 LEU   A N   1 
ATOM   1561 C CA  . LEU   A 1 205 ? 12.94474  21.24563 -12.13662 1.000 16.82215 ? 205 LEU   A CA  1 
ATOM   1562 C C   . LEU   A 1 205 ? 13.29806  22.12563 -13.33404 1.000 17.52614 ? 205 LEU   A C   1 
ATOM   1563 O O   . LEU   A 1 205 ? 14.13240  23.02916 -13.20949 1.000 15.08610 ? 205 LEU   A O   1 
ATOM   1564 C CB  . LEU   A 1 205 ? 13.76504  19.94915 -12.15972 1.000 15.95830 ? 205 LEU   A CB  1 
ATOM   1565 C CG  . LEU   A 1 205 ? 13.72982  19.19830 -10.80558 1.000 15.05501 ? 205 LEU   A CG  1 
ATOM   1566 C CD1 . LEU   A 1 205 ? 14.06775  17.69522 -10.95941 1.000 17.72672 ? 205 LEU   A CD1 1 
ATOM   1567 C CD2 . LEU   A 1 205 ? 14.66885  19.91795 -9.85466  1.000 12.24294 ? 205 LEU   A CD2 1 
ATOM   1568 N N   . ALA   A 1 206 ? 12.69371  21.86772 -14.50819 1.000 13.85361 ? 206 ALA   A N   1 
ATOM   1569 C CA  . ALA   A 1 206 ? 12.99089  22.72797 -15.66463 1.000 18.34103 ? 206 ALA   A CA  1 
ATOM   1570 C C   . ALA   A 1 206 ? 12.63057  24.17432 -15.36015 1.000 17.04588 ? 206 ALA   A C   1 
ATOM   1571 O O   . ALA   A 1 206 ? 13.37117  25.10627 -15.69300 1.000 17.62163 ? 206 ALA   A O   1 
ATOM   1572 C CB  . ALA   A 1 206 ? 12.22267  22.26192 -16.90870 1.000 13.76768 ? 206 ALA   A CB  1 
ATOM   1573 N N   . TRP   A 1 207 ? 11.48856  24.36570 -14.71563 1.000 15.27967 ? 207 TRP   A N   1 
ATOM   1574 C CA  . TRP   A 1 207 ? 10.99604  25.69367 -14.38199 1.000 19.15623 ? 207 TRP   A CA  1 
ATOM   1575 C C   . TRP   A 1 207 ? 11.89412  26.38273 -13.35325 1.000 17.64724 ? 207 TRP   A C   1 
ATOM   1576 O O   . TRP   A 1 207 ? 12.01904  27.61163 -13.38219 1.000 19.27114 ? 207 TRP   A O   1 
ATOM   1577 C CB  . TRP   A 1 207 ? 9.55768   25.54755 -13.88793 1.000 15.58388 ? 207 TRP   A CB  1 
ATOM   1578 C CG  . TRP   A 1 207 ? 8.82818   26.80872 -13.41215 1.000 18.12732 ? 207 TRP   A CG  1 
ATOM   1579 C CD1 . TRP   A 1 207 ? 8.31373   27.80147 -14.18580 1.000 24.43301 ? 207 TRP   A CD1 1 
ATOM   1580 C CD2 . TRP   A 1 207 ? 8.54252   27.16261 -12.06239 1.000 21.25523 ? 207 TRP   A CD2 1 
ATOM   1581 N NE1 . TRP   A 1 207 ? 7.69208   28.75269 -13.39675 1.000 21.44267 ? 207 TRP   A NE1 1 
ATOM   1582 C CE2 . TRP   A 1 207 ? 7.83796   28.38948 -12.08777 1.000 24.15136 ? 207 TRP   A CE2 1 
ATOM   1583 C CE3 . TRP   A 1 207 ? 8.80697   26.56827 -10.83447 1.000 24.24201 ? 207 TRP   A CE3 1 
ATOM   1584 C CZ2 . TRP   A 1 207 ? 7.39965   29.02473 -10.93247 1.000 27.94199 ? 207 TRP   A CZ2 1 
ATOM   1585 C CZ3 . TRP   A 1 207 ? 8.36653   27.21159 -9.67708  1.000 24.73936 ? 207 TRP   A CZ3 1 
ATOM   1586 C CH2 . TRP   A 1 207 ? 7.68125   28.42706 -9.74364  1.000 23.23500 ? 207 TRP   A CH2 1 
ATOM   1587 N N   . LEU   A 1 208 ? 12.50621  25.62834 -12.42266 1.000 17.80867 ? 208 LEU   A N   1 
ATOM   1588 C CA  . LEU   A 1 208 ? 13.46092  26.24665 -11.49059 1.000 18.35466 ? 208 LEU   A CA  1 
ATOM   1589 C C   . LEU   A 1 208 ? 14.71262  26.75030 -12.22621 1.000 20.17300 ? 208 LEU   A C   1 
ATOM   1590 O O   . LEU   A 1 208 ? 15.27601  27.80519 -11.89454 1.000 18.99677 ? 208 LEU   A O   1 
ATOM   1591 C CB  . LEU   A 1 208 ? 13.83002  25.23848 -10.37941 1.000 16.20898 ? 208 LEU   A CB  1 
ATOM   1592 C CG  . LEU   A 1 208 ? 12.68118  24.89390 -9.42753  1.000 15.62952 ? 208 LEU   A CG  1 
ATOM   1593 C CD1 . LEU   A 1 208 ? 13.12082  23.84353 -8.38876  1.000 17.37533 ? 208 LEU   A CD1 1 
ATOM   1594 C CD2 . LEU   A 1 208 ? 12.15291  26.15732 -8.72588  1.000 16.83843 ? 208 LEU   A CD2 1 
ATOM   1595 N N   . TYR   A 1 209 ? 15.15853  26.01822 -13.23509 1.000 17.11479 ? 209 TYR   A N   1 
ATOM   1596 C CA  . TYR   A 1 209 ? 16.25583  26.50025 -14.06039 1.000 15.30586 ? 209 TYR   A CA  1 
ATOM   1597 C C   . TYR   A 1 209 ? 15.85867  27.76957 -14.78171 1.000 16.25981 ? 209 TYR   A C   1 
ATOM   1598 O O   . TYR   A 1 209 ? 16.63481  28.73077 -14.83342 1.000 20.86682 ? 209 TYR   A O   1 
ATOM   1599 C CB  . TYR   A 1 209 ? 16.67358  25.43289 -15.06994 1.000 17.68656 ? 209 TYR   A CB  1 
ATOM   1600 C CG  . TYR   A 1 209 ? 17.62443  24.39166 -14.53274 1.000 19.11627 ? 209 TYR   A CG  1 
ATOM   1601 C CD1 . TYR   A 1 209 ? 18.97165  24.69466 -14.31110 1.000 20.14347 ? 209 TYR   A CD1 1 
ATOM   1602 C CD2 . TYR   A 1 209 ? 17.19004  23.09428 -14.26241 1.000 19.97517 ? 209 TYR   A CD2 1 
ATOM   1603 C CE1 . TYR   A 1 209 ? 19.84868  23.74052 -13.82425 1.000 23.51446 ? 209 TYR   A CE1 1 
ATOM   1604 C CE2 . TYR   A 1 209 ? 18.06090  22.13268 -13.78015 1.000 21.88799 ? 209 TYR   A CE2 1 
ATOM   1605 C CZ  . TYR   A 1 209 ? 19.39740  22.46921 -13.56662 1.000 22.77685 ? 209 TYR   A CZ  1 
ATOM   1606 O OH  . TYR   A 1 209 ? 20.27266  21.53036 -13.07803 1.000 25.06923 ? 209 TYR   A OH  1 
ATOM   1607 N N   . ALA   A 1 210 ? 14.63471  27.80408 -15.32616 1.000 17.43052 ? 210 ALA   A N   1 
ATOM   1608 C CA  . ALA   A 1 210 ? 14.15361  29.02413 -15.96487 1.000 19.94272 ? 210 ALA   A CA  1 
ATOM   1609 C C   . ALA   A 1 210 ? 14.12296  30.18948 -14.98795 1.000 20.57198 ? 210 ALA   A C   1 
ATOM   1610 O O   . ALA   A 1 210 ? 14.40353  31.33286 -15.37172 1.000 21.74737 ? 210 ALA   A O   1 
ATOM   1611 C CB  . ALA   A 1 210 ? 12.76379  28.79770 -16.55317 1.000 15.84340 ? 210 ALA   A CB  1 
ATOM   1612 N N   . ALA   A 1 211 ? 13.74049  29.92435 -13.73297 1.000 17.43160 ? 211 ALA   A N   1 
ATOM   1613 C CA  . ALA   A 1 211 ? 13.71109  30.98138 -12.72729 1.000 17.15318 ? 211 ALA   A CA  1 
ATOM   1614 C C   . ALA   A 1 211 ? 15.10131  31.54714 -12.49280 1.000 19.90701 ? 211 ALA   A C   1 
ATOM   1615 O O   . ALA   A 1 211 ? 15.29085  32.76700 -12.51167 1.000 24.22601 ? 211 ALA   A O   1 
ATOM   1616 C CB  . ALA   A 1 211 ? 13.12815  30.45435 -11.41449 1.000 18.39619 ? 211 ALA   A CB  1 
ATOM   1617 N N   . VAL   A 1 212 ? 16.08997  30.66882 -12.27240 1.000 19.27506 ? 212 VAL   A N   1 
ATOM   1618 C CA  . VAL   A 1 212 ? 17.45908  31.12380 -12.04144 1.000 20.09071 ? 212 VAL   A CA  1 
ATOM   1619 C C   . VAL   A 1 212 ? 17.96455  31.93571 -13.23390 1.000 26.67522 ? 212 VAL   A C   1 
ATOM   1620 O O   . VAL   A 1 212 ? 18.57171  33.00278 -13.06093 1.000 24.03239 ? 212 VAL   A O   1 
ATOM   1621 C CB  . VAL   A 1 212 ? 18.38463  29.93432 -11.73779 1.000 24.32512 ? 212 VAL   A CB  1 
ATOM   1622 C CG1 . VAL   A 1 212 ? 19.82973  30.41305 -11.59784 1.000 22.21235 ? 212 VAL   A CG1 1 
ATOM   1623 C CG2 . VAL   A 1 212 ? 17.91702  29.20727 -10.49439 1.000 20.21008 ? 212 VAL   A CG2 1 
ATOM   1624 N N   . ILE   A 1 213 ? 17.69813  31.46621 -14.46043 1.000 22.83212 ? 213 ILE   A N   1 
ATOM   1625 C CA  . ILE   A 1 213 ? 18.16738  32.19656 -15.64752 1.000 23.96931 ? 213 ILE   A CA  1 
ATOM   1626 C C   . ILE   A 1 213 ? 17.60302  33.61945 -15.68231 1.000 28.94968 ? 213 ILE   A C   1 
ATOM   1627 O O   . ILE   A 1 213 ? 18.26183  34.54067 -16.18631 1.000 31.70041 ? 213 ILE   A O   1 
ATOM   1628 C CB  . ILE   A 1 213 ? 17.81753  31.40574 -16.92903 1.000 28.09539 ? 213 ILE   A CB  1 
ATOM   1629 C CG1 . ILE   A 1 213 ? 18.74527  30.20872 -17.07729 1.000 25.93058 ? 213 ILE   A CG1 1 
ATOM   1630 C CG2 . ILE   A 1 213 ? 17.90592  32.26880 -18.20091 1.000 32.33779 ? 213 ILE   A CG2 1 
ATOM   1631 C CD1 . ILE   A 1 213 ? 18.19034  29.15729 -17.98271 1.000 25.89972 ? 213 ILE   A CD1 1 
ATOM   1632 N N   . ASN   A 1 214 ? 16.41353  33.83689 -15.10328 1.000 26.28643 ? 214 ASN   A N   1 
ATOM   1633 C CA  . ASN   A 1 214 ? 15.67877  35.09404 -15.21429 1.000 26.73873 ? 214 ASN   A CA  1 
ATOM   1634 C C   . ASN   A 1 214 ? 15.59485  35.88933 -13.91165 1.000 32.66456 ? 214 ASN   A C   1 
ATOM   1635 O O   . ASN   A 1 214 ? 14.71814  36.74979 -13.77206 1.000 33.36925 ? 214 ASN   A O   1 
ATOM   1636 C CB  . ASN   A 1 214 ? 14.28171  34.80462 -15.75677 1.000 28.27703 ? 214 ASN   A CB  1 
ATOM   1637 C CG  . ASN   A 1 214 ? 14.30721  34.55805 -17.23832 1.000 32.65597 ? 214 ASN   A CG  1 
ATOM   1638 O OD1 . ASN   A 1 214 ? 14.34211  35.50483 -18.02878 1.000 36.62592 ? 214 ASN   A OD1 1 
ATOM   1639 N ND2 . ASN   A 1 214 ? 14.36893  33.28467 -17.63468 1.000 34.17770 ? 214 ASN   A ND2 1 
ATOM   1640 N N   . GLY   A 1 215 ? 16.47181  35.63229 -12.95097 1.000 30.38003 ? 215 GLY   A N   1 
ATOM   1641 C CA  . GLY   A 1 215 ? 16.62938  36.53429 -11.82312 1.000 32.30432 ? 215 GLY   A CA  1 
ATOM   1642 C C   . GLY   A 1 215 ? 16.14785  36.03308 -10.47634 1.000 34.57917 ? 215 GLY   A C   1 
ATOM   1643 O O   . GLY   A 1 215 ? 16.39686  36.70524 -9.46733  1.000 36.79758 ? 215 GLY   A O   1 
ATOM   1644 N N   . ASP   A 1 216 ? 15.46981  34.89527 -10.40870 1.000 29.49018 ? 216 ASP   A N   1 
ATOM   1645 C CA  . ASP   A 1 216 ? 14.93860  34.37323 -9.14478  1.000 29.63469 ? 216 ASP   A CA  1 
ATOM   1646 C C   . ASP   A 1 216 ? 15.85705  33.24988 -8.68069  1.000 29.04629 ? 216 ASP   A C   1 
ATOM   1647 O O   . ASP   A 1 216 ? 15.73813  32.11309 -9.14862  1.000 30.97936 ? 216 ASP   A O   1 
ATOM   1648 C CB  . ASP   A 1 216 ? 13.49792  33.88936 -9.32677  1.000 29.59153 ? 216 ASP   A CB  1 
ATOM   1649 C CG  . ASP   A 1 216 ? 12.46915  34.84844 -8.73394  1.000 37.23365 ? 216 ASP   A CG  1 
ATOM   1650 O OD1 . ASP   A 1 216 ? 12.80855  35.56355 -7.76133  1.000 41.06425 ? 216 ASP   A OD1 1 
ATOM   1651 O OD2 . ASP   A 1 216 ? 11.33675  34.92036 -9.27179  1.000 38.13856 ? 216 ASP   A OD2 1 
ATOM   1652 N N   . ARG   A 1 217 ? 16.75867  33.55971 -7.73986  1.000 24.46544 ? 217 ARG   A N   1 
ATOM   1653 C CA  . ARG   A 1 217 ? 17.75289  32.59820 -7.27452  1.000 26.02987 ? 217 ARG   A CA  1 
ATOM   1654 C C   . ARG   A 1 217 ? 17.71604  32.33829 -5.77216  1.000 24.80518 ? 217 ARG   A C   1 
ATOM   1655 O O   . ARG   A 1 217 ? 18.57007  31.59330 -5.27052  1.000 26.62143 ? 217 ARG   A O   1 
ATOM   1656 C CB  . ARG   A 1 217 ? 19.15836  33.06947 -7.66674  1.000 29.28332 ? 217 ARG   A CB  1 
ATOM   1657 C CG  . ARG   A 1 217 ? 19.51528  34.37004 -6.99944  1.000 37.51057 ? 217 ARG   A CG  1 
ATOM   1658 C CD  . ARG   A 1 217 ? 20.95404  34.76915 -7.19608  1.000 39.80503 ? 217 ARG   A CD  1 
ATOM   1659 N NE  . ARG   A 1 217 ? 21.34316  35.72943 -6.17249  1.000 39.85938 ? 217 ARG   A NE  1 
ATOM   1660 C CZ  . ARG   A 1 217 ? 21.35290  37.03779 -6.37229  1.000 43.74754 ? 217 ARG   A CZ  1 
ATOM   1661 N NH1 . ARG   A 1 217 ? 20.90301  37.56488 -7.50297  1.000 37.72903 ? 217 ARG   A NH1 1 
ATOM   1662 N NH2 . ARG   A 1 217 ? 21.80245  37.83852 -5.40972  1.000 37.44130 ? 217 ARG   A NH2 1 
ATOM   1663 N N   . TRP   A 1 218 ? 16.75259  32.90465 -5.03841  1.000 24.83053 ? 218 TRP   A N   1 
ATOM   1664 C CA  . TRP   A 1 218 ? 16.77543  32.80328 -3.57501  1.000 24.22457 ? 218 TRP   A CA  1 
ATOM   1665 C C   . TRP   A 1 218 ? 16.64735  31.36756 -3.06618  1.000 26.21209 ? 218 TRP   A C   1 
ATOM   1666 O O   . TRP   A 1 218 ? 17.08417  31.08795 -1.94526  1.000 23.83757 ? 218 TRP   A O   1 
ATOM   1667 C CB  . TRP   A 1 218 ? 15.66566  33.65975 -2.95589  1.000 26.94608 ? 218 TRP   A CB  1 
ATOM   1668 C CG  . TRP   A 1 218 ? 14.26623  33.23655 -3.37472  1.000 28.42265 ? 218 TRP   A CG  1 
ATOM   1669 C CD1 . TRP   A 1 218 ? 13.52239  33.75031 -4.40210  1.000 27.33219 ? 218 TRP   A CD1 1 
ATOM   1670 C CD2 . TRP   A 1 218 ? 13.45936  32.21264 -2.77107  1.000 25.94996 ? 218 TRP   A CD2 1 
ATOM   1671 N NE1 . TRP   A 1 218 ? 12.30518  33.11397 -4.47485  1.000 21.16356 ? 218 TRP   A NE1 1 
ATOM   1672 C CE2 . TRP   A 1 218 ? 12.24204  32.16866 -3.47938  1.000 28.39379 ? 218 TRP   A CE2 1 
ATOM   1673 C CE3 . TRP   A 1 218 ? 13.64376  31.34652 -1.69171  1.000 26.80341 ? 218 TRP   A CE3 1 
ATOM   1674 C CZ2 . TRP   A 1 218 ? 11.21217  31.27234 -3.14979  1.000 27.50191 ? 218 TRP   A CZ2 1 
ATOM   1675 C CZ3 . TRP   A 1 218 ? 12.63246  30.46373 -1.36424  1.000 30.41843 ? 218 TRP   A CZ3 1 
ATOM   1676 C CH2 . TRP   A 1 218 ? 11.42925  30.42668 -2.09788  1.000 29.81565 ? 218 TRP   A CH2 1 
ATOM   1677 N N   . PHE   A 1 219 ? 16.06984  30.44775 -3.85216  1.000 23.94815 ? 219 PHE   A N   1 
ATOM   1678 C CA  . PHE   A 1 219 ? 15.86272  29.07362 -3.38983  1.000 23.87707 ? 219 PHE   A CA  1 
ATOM   1679 C C   . PHE   A 1 219 ? 17.06905  28.15735 -3.57971  1.000 24.90893 ? 219 PHE   A C   1 
ATOM   1680 O O   . PHE   A 1 219 ? 16.99952  27.00151 -3.14375  1.000 24.29580 ? 219 PHE   A O   1 
ATOM   1681 C CB  . PHE   A 1 219 ? 14.65376  28.45526 -4.09823  1.000 19.88186 ? 219 PHE   A CB  1 
ATOM   1682 C CG  . PHE   A 1 219 ? 14.72240  28.60717 -5.57087  1.000 20.60909 ? 219 PHE   A CG  1 
ATOM   1683 C CD1 . PHE   A 1 219 ? 15.42760  27.68766 -6.34557  1.000 24.29599 ? 219 PHE   A CD1 1 
ATOM   1684 C CD2 . PHE   A 1 219 ? 14.14576  29.71405 -6.18912  1.000 18.70001 ? 219 PHE   A CD2 1 
ATOM   1685 C CE1 . PHE   A 1 219 ? 15.54215  27.85651 -7.72116  1.000 20.75236 ? 219 PHE   A CE1 1 
ATOM   1686 C CE2 . PHE   A 1 219 ? 14.23898  29.87605 -7.54263  1.000 23.71532 ? 219 PHE   A CE2 1 
ATOM   1687 C CZ  . PHE   A 1 219 ? 14.93847  28.95498 -8.31808  1.000 20.13701 ? 219 PHE   A CZ  1 
ATOM   1688 N N   . LEU   A 1 220 ? 18.15238  28.61224 -4.21677  1.000 23.30585 ? 220 LEU   A N   1 
ATOM   1689 C CA  . LEU   A 1 220 ? 19.32525  27.75817 -4.38339  1.000 23.74983 ? 220 LEU   A CA  1 
ATOM   1690 C C   . LEU   A 1 220 ? 20.02179  27.56157 -3.03459  1.000 26.57555 ? 220 LEU   A C   1 
ATOM   1691 O O   . LEU   A 1 220 ? 20.16562  28.50800 -2.25983  1.000 30.49416 ? 220 LEU   A O   1 
ATOM   1692 C CB  . LEU   A 1 220 ? 20.31455  28.36931 -5.38796  1.000 26.27018 ? 220 LEU   A CB  1 
ATOM   1693 C CG  . LEU   A 1 220 ? 19.88939  28.57553 -6.85103  1.000 28.19900 ? 220 LEU   A CG  1 
ATOM   1694 C CD1 . LEU   A 1 220 ? 20.95293  29.33939 -7.61677  1.000 25.85556 ? 220 LEU   A CD1 1 
ATOM   1695 C CD2 . LEU   A 1 220 ? 19.53565  27.25682 -7.53945  1.000 25.50670 ? 220 LEU   A CD2 1 
ATOM   1696 N N   . ASN   A 1 221 ? 20.42366  26.32805 -2.73000  1.000 26.18889 ? 221 ASN   A N   1 
ATOM   1697 C CA  . ASN   A 1 221 ? 21.11800  26.05857 -1.47237  1.000 28.74139 ? 221 ASN   A CA  1 
ATOM   1698 C C   . ASN   A 1 221 ? 22.47737  25.43744 -1.76951  1.000 30.01604 ? 221 ASN   A C   1 
ATOM   1699 O O   . ASN   A 1 221 ? 22.81455  25.15906 -2.92092  1.000 27.63477 ? 221 ASN   A O   1 
ATOM   1700 C CB  . ASN   A 1 221 ? 20.27816  25.17443 -0.51213  1.000 30.84432 ? 221 ASN   A CB  1 
ATOM   1701 C CG  . ASN   A 1 221 ? 19.91371  23.78804 -1.08566  1.000 31.59928 ? 221 ASN   A CG  1 
ATOM   1702 O OD1 . ASN   A 1 221 ? 20.65524  23.18607 -1.86380  1.000 27.99452 ? 221 ASN   A OD1 1 
ATOM   1703 N ND2 . ASN   A 1 221 ? 18.77919  23.26010 -0.63776  1.000 31.90026 ? 221 ASN   A ND2 1 
ATOM   1704 N N   . ARG   A 1 222 ? 23.27762  25.22336 -0.71666  1.000 28.99674 ? 222 ARG   A N   1 
ATOM   1705 C CA  . ARG   A 1 222 ? 24.65583  24.77528 -0.89722  1.000 32.26793 ? 222 ARG   A CA  1 
ATOM   1706 C C   . ARG   A 1 222 ? 24.79338  23.26568 -1.02392  1.000 30.79879 ? 222 ARG   A C   1 
ATOM   1707 O O   . ARG   A 1 222 ? 25.92068  22.77464 -1.14528  1.000 33.20399 ? 222 ARG   A O   1 
ATOM   1708 C CB  . ARG   A 1 222 ? 25.53662  25.27402 0.26724   1.000 40.09052 ? 222 ARG   A CB  1 
ATOM   1709 C CG  . ARG   A 1 222 ? 25.26575  24.59333 1.61908   1.000 36.46205 ? 222 ARG   A CG  1 
ATOM   1710 C CD  . ARG   A 1 222 ? 25.58696  25.54547 2.79852   1.000 44.44153 ? 222 ARG   A CD  1 
ATOM   1711 N NE  . ARG   A 1 222 ? 25.37640  24.92360 4.10525   1.000 47.58052 ? 222 ARG   A NE  1 
ATOM   1712 C CZ  . ARG   A 1 222 ? 24.29809  25.09925 4.86476   1.000 53.42835 ? 222 ARG   A CZ  1 
ATOM   1713 N NH1 . ARG   A 1 222 ? 23.31472  25.91113 4.49974   1.000 48.63070 ? 222 ARG   A NH1 1 
ATOM   1714 N NH2 . ARG   A 1 222 ? 24.20500  24.44742 6.02551   1.000 51.84441 ? 222 ARG   A NH2 1 
ATOM   1715 N N   . PHE   A 1 223 ? 23.68601  22.53114 -1.04408  1.000 27.88917 ? 223 PHE   A N   1 
ATOM   1716 C CA  . PHE   A 1 223 ? 23.66199  21.08582 -0.89669  1.000 30.89092 ? 223 PHE   A CA  1 
ATOM   1717 C C   . PHE   A 1 223 ? 23.54262  20.37200 -2.23613  1.000 27.63493 ? 223 PHE   A C   1 
ATOM   1718 O O   . PHE   A 1 223 ? 23.09726  20.93890 -3.24003  1.000 32.16977 ? 223 PHE   A O   1 
ATOM   1719 C CB  . PHE   A 1 223 ? 22.48637  20.67382 -0.01051  1.000 31.49768 ? 223 PHE   A CB  1 
ATOM   1720 C CG  . PHE   A 1 223 ? 22.52775  21.26588 1.35936   1.000 33.84437 ? 223 PHE   A CG  1 
ATOM   1721 C CD1 . PHE   A 1 223 ? 23.70984  21.29352 2.08136   1.000 33.77276 ? 223 PHE   A CD1 1 
ATOM   1722 C CD2 . PHE   A 1 223 ? 21.39265  21.83468 1.90799   1.000 35.61209 ? 223 PHE   A CD2 1 
ATOM   1723 C CE1 . PHE   A 1 223 ? 23.74828  21.85470 3.35247   1.000 38.95574 ? 223 PHE   A CE1 1 
ATOM   1724 C CE2 . PHE   A 1 223 ? 21.41727  22.39491 3.17367   1.000 42.72842 ? 223 PHE   A CE2 1 
ATOM   1725 C CZ  . PHE   A 1 223 ? 22.59723  22.40392 3.90297   1.000 37.34500 ? 223 PHE   A CZ  1 
ATOM   1726 N N   . THR   A 1 224 ? 23.95444  19.10569 -2.23630  1.000 29.62240 ? 224 THR   A N   1 
ATOM   1727 C CA  . THR   A 1 224 ? 23.60048  18.15754 -3.28699  1.000 26.98358 ? 224 THR   A CA  1 
ATOM   1728 C C   . THR   A 1 224 ? 22.71556  17.06143 -2.69698  1.000 31.42228 ? 224 THR   A C   1 
ATOM   1729 O O   . THR   A 1 224 ? 22.38908  17.07369 -1.50638  1.000 32.40059 ? 224 THR   A O   1 
ATOM   1730 C CB  . THR   A 1 224 ? 24.86130  17.58998 -3.96715  1.000 30.74677 ? 224 THR   A CB  1 
ATOM   1731 O OG1 . THR   A 1 224 ? 24.50991  17.01148 -5.23240  1.000 33.21924 ? 224 THR   A OG1 1 
ATOM   1732 C CG2 . THR   A 1 224 ? 25.56259  16.53892 -3.09378  1.000 29.21216 ? 224 THR   A CG2 1 
ATOM   1733 N N   . THR   A 1 225 ? 22.31439  16.11055 -3.54256  1.000 27.75947 ? 225 THR   A N   1 
ATOM   1734 C CA  . THR   A 1 225 ? 21.50761  14.98551 -3.07943  1.000 30.41569 ? 225 THR   A CA  1 
ATOM   1735 C C   . THR   A 1 225 ? 21.67597  13.84302 -4.06750  1.000 32.82107 ? 225 THR   A C   1 
ATOM   1736 O O   . THR   A 1 225 ? 22.20834  14.02248 -5.16708  1.000 30.47230 ? 225 THR   A O   1 
ATOM   1737 C CB  . THR   A 1 225 ? 20.02541  15.36860 -2.94125  1.000 32.89334 ? 225 THR   A CB  1 
ATOM   1738 O OG1 . THR   A 1 225 ? 19.28565  14.28744 -2.36238  1.000 35.36108 ? 225 THR   A OG1 1 
ATOM   1739 C CG2 . THR   A 1 225 ? 19.42322  15.69249 -4.30486  1.000 30.62627 ? 225 THR   A CG2 1 
ATOM   1740 N N   . THR   A 1 226 ? 21.22672  12.65989 -3.66456  1.000 29.98188 ? 226 THR   A N   1 
ATOM   1741 C CA  . THR   A 1 226 ? 21.15769  11.54473 -4.59617  1.000 29.01539 ? 226 THR   A CA  1 
ATOM   1742 C C   . THR   A 1 226 ? 19.74357  11.41634 -5.12837  1.000 24.16994 ? 226 THR   A C   1 
ATOM   1743 O O   . THR   A 1 226 ? 18.77866  11.86554 -4.50644  1.000 28.87734 ? 226 THR   A O   1 
ATOM   1744 C CB  . THR   A 1 226 ? 21.58341  10.21804 -3.95456  1.000 33.28688 ? 226 THR   A CB  1 
ATOM   1745 O OG1 . THR   A 1 226 ? 20.58631  9.80521  -3.00419  1.000 31.70376 ? 226 THR   A OG1 1 
ATOM   1746 C CG2 . THR   A 1 226 ? 22.93233  10.35069 -3.28845  1.000 32.86498 ? 226 THR   A CG2 1 
ATOM   1747 N N   . LEU   A 1 227 ? 19.63705  10.78608 -6.29514  1.000 23.93883 ? 227 LEU   A N   1 
ATOM   1748 C CA  . LEU   A 1 227 ? 18.33423  10.59207 -6.90515  1.000 25.38901 ? 227 LEU   A CA  1 
ATOM   1749 C C   . LEU   A 1 227 ? 17.42168  9.81019  -5.96374  1.000 27.98088 ? 227 LEU   A C   1 
ATOM   1750 O O   . LEU   A 1 227 ? 16.23524  10.12495 -5.81688  1.000 29.69475 ? 227 LEU   A O   1 
ATOM   1751 C CB  . LEU   A 1 227 ? 18.52854  9.86981  -8.24062  1.000 31.89616 ? 227 LEU   A CB  1 
ATOM   1752 C CG  . LEU   A 1 227 ? 17.31371  9.68105  -9.13477  1.000 33.75465 ? 227 LEU   A CG  1 
ATOM   1753 C CD1 . LEU   A 1 227 ? 16.86157  11.05830 -9.64267  1.000 31.70496 ? 227 LEU   A CD1 1 
ATOM   1754 C CD2 . LEU   A 1 227 ? 17.65997  8.75510  -10.28360 1.000 32.77594 ? 227 LEU   A CD2 1 
ATOM   1755 N N   . ASN   A 1 228 ? 17.97806  8.81281  -5.27559  1.000 33.18543 ? 228 ASN   A N   1 
ATOM   1756 C CA  . ASN   A 1 228 ? 17.17107  8.00432  -4.36635  1.000 30.48455 ? 228 ASN   A CA  1 
ATOM   1757 C C   . ASN   A 1 228 ? 16.70639  8.81719  -3.16281  1.000 26.35096 ? 228 ASN   A C   1 
ATOM   1758 O O   . ASN   A 1 228 ? 15.54588  8.70906  -2.74887  1.000 26.69216 ? 228 ASN   A O   1 
ATOM   1759 C CB  . ASN   A 1 228 ? 17.95873  6.77126  -3.92206  1.000 35.47371 ? 228 ASN   A CB  1 
ATOM   1760 C CG  . ASN   A 1 228 ? 17.14458  5.86055  -3.03281  1.000 41.16151 ? 228 ASN   A CG  1 
ATOM   1761 O OD1 . ASN   A 1 228 ? 17.41543  5.73672  -1.83732  1.000 48.11575 ? 228 ASN   A OD1 1 
ATOM   1762 N ND2 . ASN   A 1 228 ? 16.12769  5.22716  -3.60801  1.000 35.81027 ? 228 ASN   A ND2 1 
ATOM   1763 N N   . ASP   A 1 229 ? 17.57913  9.65554  -2.58953  1.000 27.91576 ? 229 ASP   A N   1 
ATOM   1764 C CA  . ASP   A 1 229 ? 17.15635  10.43697 -1.42543  1.000 29.20287 ? 229 ASP   A CA  1 
ATOM   1765 C C   . ASP   A 1 229 ? 16.11981  11.49328 -1.80604  1.000 29.97280 ? 229 ASP   A C   1 
ATOM   1766 O O   . ASP   A 1 229 ? 15.20132  11.78102 -1.03079  1.000 25.03081 ? 229 ASP   A O   1 
ATOM   1767 C CB  . ASP   A 1 229 ? 18.35958  11.10004 -0.74233  1.000 31.91493 ? 229 ASP   A CB  1 
ATOM   1768 C CG  . ASP   A 1 229 ? 19.41657  10.09786 -0.27776  1.000 47.16230 ? 229 ASP   A CG  1 
ATOM   1769 O OD1 . ASP   A 1 229 ? 20.59559  10.51003 -0.16608  1.000 51.27337 ? 229 ASP   A OD1 1 
ATOM   1770 O OD2 . ASP   A 1 229 ? 19.07612  8.92102  0.00418   1.000 39.54648 ? 229 ASP   A OD2 1 
ATOM   1771 N N   . PHE   A 1 230 ? 16.25352  12.09165 -2.99323  1.000 28.90632 ? 230 PHE   A N   1 
ATOM   1772 C CA  . PHE   A 1 230 ? 15.22989  13.02159 -3.46480  1.000 26.27248 ? 230 PHE   A CA  1 
ATOM   1773 C C   . PHE   A 1 230 ? 13.86130  12.33930 -3.58090  1.000 24.10000 ? 230 PHE   A C   1 
ATOM   1774 O O   . PHE   A 1 230 ? 12.84915  12.85738 -3.09441  1.000 24.97649 ? 230 PHE   A O   1 
ATOM   1775 C CB  . PHE   A 1 230 ? 15.65828  13.63309 -4.80516  1.000 27.40248 ? 230 PHE   A CB  1 
ATOM   1776 C CG  . PHE   A 1 230 ? 14.57512  14.45158 -5.45326  1.000 23.05547 ? 230 PHE   A CG  1 
ATOM   1777 C CD1 . PHE   A 1 230 ? 14.38719  15.77772 -5.08964  1.000 25.73545 ? 230 PHE   A CD1 1 
ATOM   1778 C CD2 . PHE   A 1 230 ? 13.69547  13.86803 -6.35421  1.000 25.92659 ? 230 PHE   A CD2 1 
ATOM   1779 C CE1 . PHE   A 1 230 ? 13.37708  16.52298 -5.64211  1.000 23.12249 ? 230 PHE   A CE1 1 
ATOM   1780 C CE2 . PHE   A 1 230 ? 12.67430  14.59721 -6.90888  1.000 24.16251 ? 230 PHE   A CE2 1 
ATOM   1781 C CZ  . PHE   A 1 230 ? 12.50896  15.94116 -6.54622  1.000 23.40487 ? 230 PHE   A CZ  1 
ATOM   1782 N N   . ASN   A 1 231 ? 13.81265  11.16366 -4.20804  1.000 21.79553 ? 231 ASN   A N   1 
ATOM   1783 C CA  . ASN   A 1 231 ? 12.52440  10.51937 -4.45353  1.000 27.01057 ? 231 ASN   A CA  1 
ATOM   1784 C C   . ASN   A 1 231 ? 11.86010  10.08681 -3.15013  1.000 28.27679 ? 231 ASN   A C   1 
ATOM   1785 O O   . ASN   A 1 231 ? 10.63142  10.14573 -3.03542  1.000 28.63698 ? 231 ASN   A O   1 
ATOM   1786 C CB  . ASN   A 1 231 ? 12.69512  9.31627  -5.37962  1.000 20.70437 ? 231 ASN   A CB  1 
ATOM   1787 C CG  . ASN   A 1 231 ? 12.86262  9.71666  -6.84920  1.000 28.16506 ? 231 ASN   A CG  1 
ATOM   1788 O OD1 . ASN   A 1 231 ? 12.25292  10.67005 -7.31441  1.000 25.28271 ? 231 ASN   A OD1 1 
ATOM   1789 N ND2 . ASN   A 1 231 ? 13.69276  8.98208  -7.57541  1.000 27.68653 ? 231 ASN   A ND2 1 
ATOM   1790 N N   . LEU   A 1 232 ? 12.64667  9.66648  -2.15447  1.000 29.81556 ? 232 LEU   A N   1 
ATOM   1791 C CA  . LEU   A 1 232 ? 12.05275  9.34919  -0.85155  1.000 30.06454 ? 232 LEU   A CA  1 
ATOM   1792 C C   . LEU   A 1 232 ? 11.35868  10.56172 -0.24318  1.000 28.72375 ? 232 LEU   A C   1 
ATOM   1793 O O   . LEU   A 1 232 ? 10.32082  10.42405 0.40897   1.000 33.16888 ? 232 LEU   A O   1 
ATOM   1794 C CB  . LEU   A 1 232 ? 13.11742  8.79754  0.10025   1.000 33.62958 ? 232 LEU   A CB  1 
ATOM   1795 C CG  . LEU   A 1 232 ? 13.80442  7.50144  -0.34399  1.000 37.85111 ? 232 LEU   A CG  1 
ATOM   1796 C CD1 . LEU   A 1 232 ? 14.92444  7.07709  0.61204   1.000 40.95075 ? 232 LEU   A CD1 1 
ATOM   1797 C CD2 . LEU   A 1 232 ? 12.75591  6.38175  -0.46326  1.000 41.01561 ? 232 LEU   A CD2 1 
ATOM   1798 N N   . VAL   A 1 233 ? 11.89771  11.76461 -0.46026  1.000 29.67030 ? 233 VAL   A N   1 
ATOM   1799 C CA  . VAL   A 1 233 ? 11.26023  12.95781 0.09757   1.000 27.54376 ? 233 VAL   A CA  1 
ATOM   1800 C C   . VAL   A 1 233 ? 10.05372  13.36274 -0.73647  1.000 29.81617 ? 233 VAL   A C   1 
ATOM   1801 O O   . VAL   A 1 233 ? 9.00061   13.71721 -0.19509  1.000 31.84100 ? 233 VAL   A O   1 
ATOM   1802 C CB  . VAL   A 1 233 ? 12.27201  14.11968 0.20945   1.000 27.04586 ? 233 VAL   A CB  1 
ATOM   1803 C CG1 . VAL   A 1 233 ? 11.55191  15.41559 0.58564   1.000 32.38320 ? 233 VAL   A CG1 1 
ATOM   1804 C CG2 . VAL   A 1 233 ? 13.40055  13.78935 1.20049   1.000 29.29477 ? 233 VAL   A CG2 1 
ATOM   1805 N N   . ALA   A 1 234 ? 10.18559  13.31675 -2.06818  1.000 28.60056 ? 234 ALA   A N   1 
ATOM   1806 C CA  . ALA   A 1 234 ? 9.15665   13.85060 -2.94138  1.000 27.43822 ? 234 ALA   A CA  1 
ATOM   1807 C C   . ALA   A 1 234 ? 7.91331   12.97188 -3.02731  1.000 27.10302 ? 234 ALA   A C   1 
ATOM   1808 O O   . ALA   A 1 234 ? 6.83538   13.48233 -3.34683  1.000 28.62128 ? 234 ALA   A O   1 
ATOM   1809 C CB  . ALA   A 1 234 ? 9.72779   14.05789 -4.34774  1.000 25.01114 ? 234 ALA   A CB  1 
ATOM   1810 N N   . MET   A 1 235 ? 8.01598   11.67229 -2.76640  1.000 26.85956 ? 235 MET   A N   1 
ATOM   1811 C CA  . MET   A 1 235 ? 6.85593   10.83680 -3.05536  1.000 31.31790 ? 235 MET   A CA  1 
ATOM   1812 C C   . MET   A 1 235 ? 5.69048   11.18355 -2.12810  1.000 28.85161 ? 235 MET   A C   1 
ATOM   1813 O O   . MET   A 1 235 ? 4.53038   11.08208 -2.54095  1.000 26.77234 ? 235 MET   A O   1 
ATOM   1814 C CB  . MET   A 1 235 ? 7.23907   9.35256  -2.99334  1.000 36.16548 ? 235 MET   A CB  1 
ATOM   1815 C CG  . MET   A 1 235 ? 7.44265   8.73883  -1.61740  1.000 40.50508 ? 235 MET   A CG  1 
ATOM   1816 S SD  . MET   A 1 235 ? 6.71712   7.05446  -1.54098  1.000 49.15299 ? 235 MET   A SD  1 
ATOM   1817 C CE  . MET   A 1 235 ? 7.60177   6.27854  -2.88851  1.000 42.37646 ? 235 MET   A CE  1 
ATOM   1818 N N   . LYS   A 1 236 ? 5.97546   11.71136 -0.92680  1.000 27.94049 ? 236 LYS   A N   1 
ATOM   1819 C CA  . LYS   A 1 236 ? 4.89503   12.11600 -0.02781  1.000 28.82384 ? 236 LYS   A CA  1 
ATOM   1820 C C   . LYS   A 1 236 ? 4.08532   13.29788 -0.55022  1.000 31.51164 ? 236 LYS   A C   1 
ATOM   1821 O O   . LYS   A 1 236 ? 2.95592   13.49671 -0.09834  1.000 31.75627 ? 236 LYS   A O   1 
ATOM   1822 C CB  . LYS   A 1 236 ? 5.43287   12.49815 1.35307   1.000 33.20599 ? 236 LYS   A CB  1 
ATOM   1823 C CG  . LYS   A 1 236 ? 6.37644   11.49775 1.98407   1.000 42.81294 ? 236 LYS   A CG  1 
ATOM   1824 C CD  . LYS   A 1 236 ? 6.76380   11.98069 3.37259   1.000 43.63093 ? 236 LYS   A CD  1 
ATOM   1825 C CE  . LYS   A 1 236 ? 7.26665   13.41557 3.32093   1.000 42.21276 ? 236 LYS   A CE  1 
ATOM   1826 N NZ  . LYS   A 1 236 ? 8.65110   13.48201 2.79765   1.000 38.42267 ? 236 LYS   A NZ  1 
ATOM   1827 N N   . TYR   A 1 237 ? 4.63828   14.11620 -1.44869  1.000 26.02407 ? 237 TYR   A N   1 
ATOM   1828 C CA  . TYR   A 1 237 ? 3.92598   15.27434 -1.97721  1.000 26.21053 ? 237 TYR   A CA  1 
ATOM   1829 C C   . TYR   A 1 237 ? 3.28689   15.00423 -3.32483  1.000 26.55703 ? 237 TYR   A C   1 
ATOM   1830 O O   . TYR   A 1 237 ? 2.96658   15.96276 -4.04323  1.000 27.19783 ? 237 TYR   A O   1 
ATOM   1831 C CB  . TYR   A 1 237 ? 4.86909   16.47696 -2.08273  1.000 29.65083 ? 237 TYR   A CB  1 
ATOM   1832 C CG  . TYR   A 1 237 ? 5.49453   16.82349 -0.75925  1.000 28.96195 ? 237 TYR   A CG  1 
ATOM   1833 C CD1 . TYR   A 1 237 ? 4.80441   17.57200 0.17463   1.000 31.18791 ? 237 TYR   A CD1 1 
ATOM   1834 C CD2 . TYR   A 1 237 ? 6.74342   16.35226 -0.43037  1.000 28.34781 ? 237 TYR   A CD2 1 
ATOM   1835 C CE1 . TYR   A 1 237 ? 5.35584   17.86406 1.39596   1.000 35.70811 ? 237 TYR   A CE1 1 
ATOM   1836 C CE2 . TYR   A 1 237 ? 7.30389   16.64039 0.77866   1.000 33.70233 ? 237 TYR   A CE2 1 
ATOM   1837 C CZ  . TYR   A 1 237 ? 6.60783   17.39377 1.69100   1.000 33.52749 ? 237 TYR   A CZ  1 
ATOM   1838 O OH  . TYR   A 1 237 ? 7.19098   17.67225 2.90348   1.000 38.29854 ? 237 TYR   A OH  1 
ATOM   1839 N N   . ASN   A 1 238 ? 3.11519   13.72642 -3.68548  1.000 26.65932 ? 238 ASN   A N   1 
ATOM   1840 C CA  . ASN   A 1 238 ? 2.44340   13.32007 -4.92486  1.000 23.86104 ? 238 ASN   A CA  1 
ATOM   1841 C C   . ASN   A 1 238 ? 3.18678   13.85941 -6.14392  1.000 26.47742 ? 238 ASN   A C   1 
ATOM   1842 O O   . ASN   A 1 238 ? 2.57722   14.35672 -7.08899  1.000 24.52110 ? 238 ASN   A O   1 
ATOM   1843 C CB  . ASN   A 1 238 ? 0.97663   13.76679 -4.95138  1.000 27.59599 ? 238 ASN   A CB  1 
ATOM   1844 C CG  . ASN   A 1 238 ? 0.15149   13.04156 -6.02278  1.000 29.16602 ? 238 ASN   A CG  1 
ATOM   1845 O OD1 . ASN   A 1 238 ? 0.49004   11.93611 -6.46085  1.000 31.65532 ? 238 ASN   A OD1 1 
ATOM   1846 N ND2 . ASN   A 1 238 ? -0.90755  13.69419 -6.48114  1.000 33.49988 ? 238 ASN   A ND2 1 
ATOM   1847 N N   . TYR   A 1 239 ? 4.51198   13.81209 -6.08421  1.000 23.91714 ? 239 TYR   A N   1 
ATOM   1848 C CA  . TYR   A 1 239 ? 5.37498   14.08306 -7.21996  1.000 23.73369 ? 239 TYR   A CA  1 
ATOM   1849 C C   . TYR   A 1 239 ? 5.71338   12.75266 -7.86570  1.000 26.20609 ? 239 TYR   A C   1 
ATOM   1850 O O   . TYR   A 1 239 ? 5.98570   11.77369 -7.16747  1.000 25.45453 ? 239 TYR   A O   1 
ATOM   1851 C CB  . TYR   A 1 239 ? 6.65509   14.79668 -6.77135  1.000 23.76377 ? 239 TYR   A CB  1 
ATOM   1852 C CG  . TYR   A 1 239 ? 6.53495   16.29887 -6.70182  1.000 23.00608 ? 239 TYR   A CG  1 
ATOM   1853 C CD1 . TYR   A 1 239 ? 5.56525   16.91552 -5.92299  1.000 24.04434 ? 239 TYR   A CD1 1 
ATOM   1854 C CD2 . TYR   A 1 239 ? 7.39197   17.11051 -7.43512  1.000 24.60512 ? 239 TYR   A CD2 1 
ATOM   1855 C CE1 . TYR   A 1 239 ? 5.44586   18.32024 -5.89037  1.000 26.49850 ? 239 TYR   A CE1 1 
ATOM   1856 C CE2 . TYR   A 1 239 ? 7.28634   18.47769 -7.40145  1.000 18.95128 ? 239 TYR   A CE2 1 
ATOM   1857 C CZ  . TYR   A 1 239 ? 6.32038   19.07856 -6.63764  1.000 24.40976 ? 239 TYR   A CZ  1 
ATOM   1858 O OH  . TYR   A 1 239 ? 6.25025   20.43692 -6.63521  1.000 23.30274 ? 239 TYR   A OH  1 
ATOM   1859 N N   . GLU   A 1 240 ? 5.70853   12.71183 -9.19448  1.000 24.84580 ? 240 GLU   A N   1 
ATOM   1860 C CA  . GLU   A 1 240 ? 6.09643   11.48462 -9.86711  1.000 26.62866 ? 240 GLU   A CA  1 
ATOM   1861 C C   . GLU   A 1 240 ? 7.59067   11.19538 -9.65297  1.000 23.14051 ? 240 GLU   A C   1 
ATOM   1862 O O   . GLU   A 1 240 ? 8.39440   12.11529 -9.41379  1.000 23.53622 ? 240 GLU   A O   1 
ATOM   1863 C CB  . GLU   A 1 240 ? 5.72321   11.57191 -11.34597 1.000 26.92181 ? 240 GLU   A CB  1 
ATOM   1864 C CG  . GLU   A 1 240 ? 6.52034   12.52397 -12.19344 1.000 30.86725 ? 240 GLU   A CG  1 
ATOM   1865 C CD  . GLU   A 1 240 ? 6.14410   12.41015 -13.68261 1.000 39.57912 ? 240 GLU   A CD  1 
ATOM   1866 O OE1 . GLU   A 1 240 ? 4.95689   12.12102 -13.96271 1.000 39.31682 ? 240 GLU   A OE1 1 
ATOM   1867 O OE2 . GLU   A 1 240 ? 7.01321   12.63238 -14.57042 1.000 34.78887 ? 240 GLU   A OE2 1 
ATOM   1868 N N   . PRO   A 1 241 ? 7.98111   9.91844  -9.64956  1.000 24.01288 ? 241 PRO   A N   1 
ATOM   1869 C CA  . PRO   A 1 241 ? 9.38659   9.58321  -9.39866  1.000 23.53267 ? 241 PRO   A CA  1 
ATOM   1870 C C   . PRO   A 1 241 ? 10.28252  10.17501 -10.47756 1.000 28.11439 ? 241 PRO   A C   1 
ATOM   1871 O O   . PRO   A 1 241 ? 9.93655   10.18171 -11.66218 1.000 25.78628 ? 241 PRO   A O   1 
ATOM   1872 C CB  . PRO   A 1 241 ? 9.40209   8.05253  -9.45690  1.000 29.74852 ? 241 PRO   A CB  1 
ATOM   1873 C CG  . PRO   A 1 241 ? 8.00376   7.64652  -9.15863  1.000 25.67371 ? 241 PRO   A CG  1 
ATOM   1874 C CD  . PRO   A 1 241 ? 7.15294   8.70560  -9.79056  1.000 27.64830 ? 241 PRO   A CD  1 
ATOM   1875 N N   . LEU   A 1 242 ? 11.43174  10.68501 -10.05172 1.000 24.01828 ? 242 LEU   A N   1 
ATOM   1876 C CA  . LEU   A 1 242 ? 12.44296  11.19918 -10.96408 1.000 27.60992 ? 242 LEU   A CA  1 
ATOM   1877 C C   . LEU   A 1 242 ? 13.36163  10.05116 -11.35897 1.000 26.39808 ? 242 LEU   A C   1 
ATOM   1878 O O   . LEU   A 1 242 ? 13.96164  9.41501  -10.49081 1.000 25.55228 ? 242 LEU   A O   1 
ATOM   1879 C CB  . LEU   A 1 242 ? 13.22372  12.34341 -10.30437 1.000 22.54283 ? 242 LEU   A CB  1 
ATOM   1880 C CG  . LEU   A 1 242 ? 14.01231  13.23998 -11.26859 1.000 25.15496 ? 242 LEU   A CG  1 
ATOM   1881 C CD1 . LEU   A 1 242 ? 13.07565  14.04751 -12.15082 1.000 27.00093 ? 242 LEU   A CD1 1 
ATOM   1882 C CD2 . LEU   A 1 242 ? 14.94781  14.15446 -10.50326 1.000 26.08263 ? 242 LEU   A CD2 1 
ATOM   1883 N N   . THR   A 1 243 ? 13.42839  9.76169  -12.66115 1.000 27.36177 ? 243 THR   A N   1 
ATOM   1884 C CA  . THR   A 1 243 ? 14.21907  8.68145  -13.23007 1.000 28.07357 ? 243 THR   A CA  1 
ATOM   1885 C C   . THR   A 1 243 ? 15.56346  9.20518  -13.72585 1.000 29.50131 ? 243 THR   A C   1 
ATOM   1886 O O   . THR   A 1 243 ? 15.75067  10.41240 -13.92364 1.000 24.73988 ? 243 THR   A O   1 
ATOM   1887 C CB  . THR   A 1 243 ? 13.45833  8.02187  -14.38876 1.000 25.86047 ? 243 THR   A CB  1 
ATOM   1888 O OG1 . THR   A 1 243 ? 13.42842  8.90695  -15.51822 1.000 24.68910 ? 243 THR   A OG1 1 
ATOM   1889 C CG2 . THR   A 1 243 ? 12.02116  7.75184  -13.98786 1.000 24.95385 ? 243 THR   A CG2 1 
ATOM   1890 N N   . GLN   A 1 244 ? 16.50874  8.27694  -13.93944 1.000 23.78197 ? 244 GLN   A N   1 
ATOM   1891 C CA  . GLN   A 1 244 ? 17.79308  8.69238  -14.50204 1.000 28.49324 ? 244 GLN   A CA  1 
ATOM   1892 C C   . GLN   A 1 244 ? 17.62098  9.27119  -15.89753 1.000 21.22516 ? 244 GLN   A C   1 
ATOM   1893 O O   . GLN   A 1 244 ? 18.39217  10.15410 -16.29836 1.000 26.52112 ? 244 GLN   A O   1 
ATOM   1894 C CB  . GLN   A 1 244 ? 18.79868  7.52981  -14.53361 1.000 27.83792 ? 244 GLN   A CB  1 
ATOM   1895 C CG  . GLN   A 1 244 ? 20.19901  7.96851  -15.01879 1.000 24.60450 ? 244 GLN   A CG  1 
ATOM   1896 C CD  . GLN   A 1 244 ? 20.86107  9.00279  -14.10339 1.000 31.38939 ? 244 GLN   A CD  1 
ATOM   1897 O OE1 . GLN   A 1 244 ? 20.81453  8.86446  -12.88982 1.000 26.97239 ? 244 GLN   A OE1 1 
ATOM   1898 N NE2 . GLN   A 1 244 ? 21.51267  10.01880 -14.68904 1.000 26.65275 ? 244 GLN   A NE2 1 
ATOM   1899 N N   . ASP   A 1 245 ? 16.61977  8.80291  -16.65844 1.000 21.95759 ? 245 ASP   A N   1 
ATOM   1900 C CA  . ASP   A 1 245 ? 16.35809  9.42430  -17.95923 1.000 25.41103 ? 245 ASP   A CA  1 
ATOM   1901 C C   . ASP   A 1 245 ? 15.96811  10.88774 -17.79667 1.000 27.06198 ? 245 ASP   A C   1 
ATOM   1902 O O   . ASP   A 1 245 ? 16.33951  11.72803 -18.62509 1.000 19.80940 ? 245 ASP   A O   1 
ATOM   1903 C CB  . ASP   A 1 245 ? 15.24177  8.70922  -18.71653 1.000 27.62301 ? 245 ASP   A CB  1 
ATOM   1904 C CG  . ASP   A 1 245 ? 15.70854  7.45512  -19.42474 1.000 35.33557 ? 245 ASP   A CG  1 
ATOM   1905 O OD1 . ASP   A 1 245 ? 16.92750  7.15302  -19.44946 1.000 29.56690 ? 245 ASP   A OD1 1 
ATOM   1906 O OD2 . ASP   A 1 245 ? 14.82603  6.78166  -19.98658 1.000 33.74373 ? 245 ASP   A OD2 1 
ATOM   1907 N N   . HIS   A 1 246 ? 15.19605  11.20790 -16.74393 1.000 26.40495 ? 246 HIS   A N   1 
ATOM   1908 C CA  . HIS   A 1 246 ? 14.81708  12.59692 -16.47900 1.000 21.67336 ? 246 HIS   A CA  1 
ATOM   1909 C C   . HIS   A 1 246 ? 16.02250  13.45522 -16.12506 1.000 22.12275 ? 246 HIS   A C   1 
ATOM   1910 O O   . HIS   A 1 246 ? 16.10535  14.61885 -16.54533 1.000 20.77346 ? 246 HIS   A O   1 
ATOM   1911 C CB  . HIS   A 1 246 ? 13.80090  12.68698 -15.33477 1.000 21.70092 ? 246 HIS   A CB  1 
ATOM   1912 C CG  . HIS   A 1 246 ? 12.46597  12.08658 -15.65102 1.000 23.97671 ? 246 HIS   A CG  1 
ATOM   1913 N ND1 . HIS   A 1 246 ? 11.70027  11.43922 -14.69766 1.000 24.85951 ? 246 HIS   A ND1 1 
ATOM   1914 C CD2 . HIS   A 1 246 ? 11.75376  12.03923 -16.80184 1.000 24.37818 ? 246 HIS   A CD2 1 
ATOM   1915 C CE1 . HIS   A 1 246 ? 10.57819  11.01414 -15.25361 1.000 27.17850 ? 246 HIS   A CE1 1 
ATOM   1916 N NE2 . HIS   A 1 246 ? 10.58410  11.36503 -16.52834 1.000 27.41839 ? 246 HIS   A NE2 1 
ATOM   1917 N N   . VAL   A 1 247 ? 16.93296  12.91819 -15.30980 1.000 23.50525 ? 247 VAL   A N   1 
ATOM   1918 C CA  . VAL   A 1 247 ? 18.16763  13.62948 -14.99086 1.000 25.28447 ? 247 VAL   A CA  1 
ATOM   1919 C C   . VAL   A 1 247 ? 18.94798  13.92602 -16.26261 1.000 22.66600 ? 247 VAL   A C   1 
ATOM   1920 O O   . VAL   A 1 247 ? 19.46427  15.03254 -16.45669 1.000 22.24788 ? 247 VAL   A O   1 
ATOM   1921 C CB  . VAL   A 1 247 ? 18.99075  12.80491 -13.98859 1.000 22.40340 ? 247 VAL   A CB  1 
ATOM   1922 C CG1 . VAL   A 1 247 ? 20.37043  13.39548 -13.80831 1.000 25.96627 ? 247 VAL   A CG1 1 
ATOM   1923 C CG2 . VAL   A 1 247 ? 18.23234  12.70739 -12.66858 1.000 25.13960 ? 247 VAL   A CG2 1 
ATOM   1924 N N   . ASP   A 1 248 ? 19.00597  12.95838 -17.16490 1.000 20.47278 ? 248 ASP   A N   1 
ATOM   1925 C CA  . ASP   A 1 248 ? 19.75489  13.13559 -18.40407 1.000 23.98303 ? 248 ASP   A CA  1 
ATOM   1926 C C   . ASP   A 1 248 ? 19.10877  14.17577 -19.31082 1.000 21.50258 ? 248 ASP   A C   1 
ATOM   1927 O O   . ASP   A 1 248 ? 19.81137  14.91364 -20.00052 1.000 23.11903 ? 248 ASP   A O   1 
ATOM   1928 C CB  . ASP   A 1 248 ? 19.85247  11.79884 -19.12981 1.000 21.75839 ? 248 ASP   A CB  1 
ATOM   1929 C CG  . ASP   A 1 248 ? 20.68613  10.76935 -18.37478 1.000 24.14950 ? 248 ASP   A CG  1 
ATOM   1930 O OD1 . ASP   A 1 248 ? 21.32104  11.11295 -17.35684 1.000 27.88996 ? 248 ASP   A OD1 1 
ATOM   1931 O OD2 . ASP   A 1 248 ? 20.72295  9.59653  -18.81710 1.000 25.24732 ? 248 ASP   A OD2 1 
ATOM   1932 N N   . ILE   A 1 249 ? 17.77293  14.20142 -19.36311 1.000 20.14550 ? 249 ILE   A N   1 
ATOM   1933 C CA  . ILE   A 1 249 ? 17.02900  15.17135 -20.16360 1.000 21.29224 ? 249 ILE   A CA  1 
ATOM   1934 C C   . ILE   A 1 249 ? 17.26944  16.58934 -19.65948 1.000 23.42842 ? 249 ILE   A C   1 
ATOM   1935 O O   . ILE   A 1 249 ? 17.32082  17.53961 -20.45371 1.000 20.16238 ? 249 ILE   A O   1 
ATOM   1936 C CB  . ILE   A 1 249 ? 15.53620  14.77946 -20.15684 1.000 21.22509 ? 249 ILE   A CB  1 
ATOM   1937 C CG1 . ILE   A 1 249 ? 15.28571  13.61792 -21.12837 1.000 25.15903 ? 249 ILE   A CG1 1 
ATOM   1938 C CG2 . ILE   A 1 249 ? 14.60722  15.94133 -20.52193 1.000 20.53655 ? 249 ILE   A CG2 1 
ATOM   1939 C CD1 . ILE   A 1 249 ? 13.98287  12.89247 -20.86427 1.000 29.88539 ? 249 ILE   A CD1 1 
ATOM   1940 N N   . LEU   A 1 250 ? 17.43857  16.75550 -18.33999 1.000 19.34343 ? 250 LEU   A N   1 
ATOM   1941 C CA  . LEU   A 1 250 ? 17.80534  18.03164 -17.72469 1.000 24.38534 ? 250 LEU   A CA  1 
ATOM   1942 C C   . LEU   A 1 250 ? 19.27484  18.40957 -17.92676 1.000 24.35863 ? 250 LEU   A C   1 
ATOM   1943 O O   . LEU   A 1 250 ? 19.65465  19.54455 -17.61840 1.000 24.95450 ? 250 LEU   A O   1 
ATOM   1944 C CB  . LEU   A 1 250 ? 17.50596  17.98763 -16.21151 1.000 25.33868 ? 250 LEU   A CB  1 
ATOM   1945 C CG  . LEU   A 1 250 ? 16.01579  17.99520 -15.83858 1.000 20.45235 ? 250 LEU   A CG  1 
ATOM   1946 C CD1 . LEU   A 1 250 ? 15.77333  17.60528 -14.39002 1.000 20.67159 ? 250 LEU   A CD1 1 
ATOM   1947 C CD2 . LEU   A 1 250 ? 15.33980  19.35138 -16.13345 1.000 20.26580 ? 250 LEU   A CD2 1 
ATOM   1948 N N   . GLY   A 1 251 ? 20.11080  17.49706 -18.42105 1.000 23.82131 ? 251 GLY   A N   1 
ATOM   1949 C CA  . GLY   A 1 251 ? 21.53336  17.73866 -18.53850 1.000 23.00910 ? 251 GLY   A CA  1 
ATOM   1950 C C   . GLY   A 1 251 ? 21.95465  19.00872 -19.26497 1.000 27.14891 ? 251 GLY   A C   1 
ATOM   1951 O O   . GLY   A 1 251 ? 22.81985  19.75180 -18.78583 1.000 25.18663 ? 251 GLY   A O   1 
ATOM   1952 N N   . PRO   A 1 252 ? 21.37928  19.28324 -20.44021 1.000 23.64098 ? 252 PRO   A N   1 
ATOM   1953 C CA  . PRO   A 1 252 ? 21.78340  20.50876 -21.15095 1.000 22.19029 ? 252 PRO   A CA  1 
ATOM   1954 C C   . PRO   A 1 252 ? 21.51059  21.78966 -20.36222 1.000 28.61950 ? 252 PRO   A C   1 
ATOM   1955 O O   . PRO   A 1 252 ? 22.31186  22.73850 -20.43362 1.000 26.91181 ? 252 PRO   A O   1 
ATOM   1956 C CB  . PRO   A 1 252 ? 20.97289  20.43898 -22.45157 1.000 26.58620 ? 252 PRO   A CB  1 
ATOM   1957 C CG  . PRO   A 1 252 ? 20.64435  18.95423 -22.62904 1.000 25.60445 ? 252 PRO   A CG  1 
ATOM   1958 C CD  . PRO   A 1 252 ? 20.48321  18.42956 -21.24659 1.000 26.25076 ? 252 PRO   A CD  1 
ATOM   1959 N N   . LEU   A 1 253 ? 20.41151  21.84195 -19.59196 1.000 25.29680 ? 253 LEU   A N   1 
ATOM   1960 C CA  . LEU   A 1 253 ? 20.13208  23.02682 -18.77637 1.000 22.88306 ? 253 LEU   A CA  1 
ATOM   1961 C C   . LEU   A 1 253 ? 21.13111  23.17962 -17.63329 1.000 22.84226 ? 253 LEU   A C   1 
ATOM   1962 O O   . LEU   A 1 253 ? 21.44328  24.30961 -17.23597 1.000 24.38178 ? 253 LEU   A O   1 
ATOM   1963 C CB  . LEU   A 1 253 ? 18.71226  22.96468 -18.20714 1.000 21.80515 ? 253 LEU   A CB  1 
ATOM   1964 C CG  . LEU   A 1 253 ? 17.59186  23.53078 -19.06814 1.000 24.37840 ? 253 LEU   A CG  1 
ATOM   1965 C CD1 . LEU   A 1 253 ? 16.26259  23.18053 -18.40721 1.000 24.44926 ? 253 LEU   A CD1 1 
ATOM   1966 C CD2 . LEU   A 1 253 ? 17.70699  25.04746 -19.23303 1.000 23.73452 ? 253 LEU   A CD2 1 
ATOM   1967 N N   . SER   A 1 254 ? 21.58947  22.06644 -17.04385 1.000 22.00545 ? 254 SER   A N   1 
ATOM   1968 C CA  . SER   A 1 254 ? 22.63716  22.15320 -16.02515 1.000 27.98078 ? 254 SER   A CA  1 
ATOM   1969 C C   . SER   A 1 254 ? 23.91805  22.74895 -16.59908 1.000 26.68674 ? 254 SER   A C   1 
ATOM   1970 O O   . SER   A 1 254 ? 24.57191  23.57459 -15.95075 1.000 25.78856 ? 254 SER   A O   1 
ATOM   1971 C CB  . SER   A 1 254 ? 22.92580  20.77470 -15.40966 1.000 27.32633 ? 254 SER   A CB  1 
ATOM   1972 O OG  . SER   A 1 254 ? 23.50315  19.87067 -16.34328 1.000 28.69217 ? 254 SER   A OG  1 
ATOM   1973 N N   . ALA   A 1 255 ? 24.28929  22.33763 -17.81232 1.000 27.13025 ? 255 ALA   A N   1 
ATOM   1974 C CA  . ALA   A 1 255 ? 25.47940  22.86859 -18.47521 1.000 33.49584 ? 255 ALA   A CA  1 
ATOM   1975 C C   . ALA   A 1 255 ? 25.32356  24.34150 -18.85826 1.000 29.79794 ? 255 ALA   A C   1 
ATOM   1976 O O   . ALA   A 1 255 ? 26.30063  25.09863 -18.83047 1.000 36.01979 ? 255 ALA   A O   1 
ATOM   1977 C CB  . ALA   A 1 255 ? 25.80029  22.02189 -19.71786 1.000 26.89643 ? 255 ALA   A CB  1 
ATOM   1978 N N   . GLN   A 1 256 ? 24.12054  24.77226 -19.22629 1.000 28.98285 ? 256 GLN   A N   1 
ATOM   1979 C CA  . GLN   A 1 256 ? 23.93283  26.18111 -19.55321 1.000 26.54975 ? 256 GLN   A CA  1 
ATOM   1980 C C   . GLN   A 1 256 ? 24.07856  27.08355 -18.31858 1.000 26.60664 ? 256 GLN   A C   1 
ATOM   1981 O O   . GLN   A 1 256 ? 24.69548  28.15417 -18.40021 1.000 30.30253 ? 256 GLN   A O   1 
ATOM   1982 C CB  . GLN   A 1 256 ? 22.57525  26.36780 -20.22425 1.000 28.58797 ? 256 GLN   A CB  1 
ATOM   1983 C CG  . GLN   A 1 256 ? 22.24674  27.81441 -20.52530 1.000 35.32821 ? 256 GLN   A CG  1 
ATOM   1984 C CD  . GLN   A 1 256 ? 20.94257  27.95623 -21.25883 1.000 41.29397 ? 256 GLN   A CD  1 
ATOM   1985 O OE1 . GLN   A 1 256 ? 20.44908  26.99321 -21.85184 1.000 42.87126 ? 256 GLN   A OE1 1 
ATOM   1986 N NE2 . GLN   A 1 256 ? 20.34948  29.15096 -21.19801 1.000 43.89494 ? 256 GLN   A NE2 1 
ATOM   1987 N N   . THR   A 1 257 ? 23.55129  26.66087 -17.16091 1.000 19.49292 ? 257 THR   A N   1 
ATOM   1988 C CA  . THR   A 1 257 ? 23.49067  27.50504 -15.96221 1.000 23.33969 ? 257 THR   A CA  1 
ATOM   1989 C C   . THR   A 1 257 ? 24.60772  27.26280 -14.96112 1.000 24.08918 ? 257 THR   A C   1 
ATOM   1990 O O   . THR   A 1 257 ? 24.68099  27.98662 -13.95642 1.000 22.21110 ? 257 THR   A O   1 
ATOM   1991 C CB  . THR   A 1 257 ? 22.19072  27.26616 -15.20275 1.000 22.23696 ? 257 THR   A CB  1 
ATOM   1992 O OG1 . THR   A 1 257 ? 22.16380  25.88411 -14.81962 1.000 19.23437 ? 257 THR   A OG1 1 
ATOM   1993 C CG2 . THR   A 1 257 ? 20.97814  27.61274 -16.07339 1.000 20.92330 ? 257 THR   A CG2 1 
ATOM   1994 N N   . GLY   A 1 258 ? 25.39904  26.21369 -15.13496 1.000 22.18631 ? 258 GLY   A N   1 
ATOM   1995 C CA  . GLY   A 1 258 ? 26.39403  25.86900 -14.15102 1.000 24.08624 ? 258 GLY   A CA  1 
ATOM   1996 C C   . GLY   A 1 258 ? 25.87207  25.24045 -12.87698 1.000 25.61113 ? 258 GLY   A C   1 
ATOM   1997 O O   . GLY   A 1 258 ? 26.63462  25.12623 -11.91028 1.000 30.14777 ? 258 GLY   A O   1 
ATOM   1998 N N   . ILE   A 1 259 ? 24.60167  24.84352 -12.82574 1.000 25.87756 ? 259 ILE   A N   1 
ATOM   1999 C CA  . ILE   A 1 259 ? 24.00701  24.24107 -11.62892 1.000 27.23732 ? 259 ILE   A CA  1 
ATOM   2000 C C   . ILE   A 1 259 ? 23.69534  22.77939 -11.93681 1.000 26.87998 ? 259 ILE   A C   1 
ATOM   2001 O O   . ILE   A 1 259 ? 22.86312  22.47973 -12.80420 1.000 23.94234 ? 259 ILE   A O   1 
ATOM   2002 C CB  . ILE   A 1 259 ? 22.73648  24.98176 -11.17603 1.000 24.33170 ? 259 ILE   A CB  1 
ATOM   2003 C CG1 . ILE   A 1 259 ? 23.01131  26.46366 -10.87474 1.000 28.57608 ? 259 ILE   A CG1 1 
ATOM   2004 C CG2 . ILE   A 1 259 ? 22.09443  24.28312 -10.00012 1.000 23.32375 ? 259 ILE   A CG2 1 
ATOM   2005 C CD1 . ILE   A 1 259 ? 21.72510  27.31808 -10.81714 1.000 22.72746 ? 259 ILE   A CD1 1 
ATOM   2006 N N   . ALA   A 1 260 ? 24.35161  21.87748 -11.21542 1.000 29.07978 ? 260 ALA   A N   1 
ATOM   2007 C CA  . ALA   A 1 260 ? 24.20745  20.45550 -11.47577 1.000 25.64889 ? 260 ALA   A CA  1 
ATOM   2008 C C   . ALA   A 1 260 ? 22.77697  20.02531 -11.21938 1.000 24.23951 ? 260 ALA   A C   1 
ATOM   2009 O O   . ALA   A 1 260 ? 22.09407  20.55560 -10.33570 1.000 23.09582 ? 260 ALA   A O   1 
ATOM   2010 C CB  . ALA   A 1 260 ? 25.17214  19.65845 -10.59426 1.000 24.19917 ? 260 ALA   A CB  1 
ATOM   2011 N N   . VAL   A 1 261 ? 22.30678  19.05881 -12.01704 1.000 23.94191 ? 261 VAL   A N   1 
ATOM   2012 C CA  . VAL   A 1 261 ? 20.92245  18.60370 -11.86600 1.000 22.28797 ? 261 VAL   A CA  1 
ATOM   2013 C C   . VAL   A 1 261 ? 20.64662  18.17535 -10.42664 1.000 23.77225 ? 261 VAL   A C   1 
ATOM   2014 O O   . VAL   A 1 261 ? 19.59497  18.49550 -9.85850  1.000 22.65567 ? 261 VAL   A O   1 
ATOM   2015 C CB  . VAL   A 1 261 ? 20.61079  17.48294 -12.87999 1.000 21.55344 ? 261 VAL   A CB  1 
ATOM   2016 C CG1 . VAL   A 1 261 ? 19.16871  16.96964 -12.69185 1.000 20.99048 ? 261 VAL   A CG1 1 
ATOM   2017 C CG2 . VAL   A 1 261 ? 20.82909  18.00329 -14.29891 1.000 21.75844 ? 261 VAL   A CG2 1 
ATOM   2018 N N   . LEU   A 1 262 ? 21.58448  17.46966 -9.79675  1.000 23.17117 ? 262 LEU   A N   1 
ATOM   2019 C CA  . LEU   A 1 262 ? 21.30099  17.01199 -8.43749  1.000 24.62030 ? 262 LEU   A CA  1 
ATOM   2020 C C   . LEU   A 1 262 ? 21.39095  18.13520 -7.41192  1.000 27.70977 ? 262 LEU   A C   1 
ATOM   2021 O O   . LEU   A 1 262 ? 20.80367  18.02179 -6.32697  1.000 25.95065 ? 262 LEU   A O   1 
ATOM   2022 C CB  . LEU   A 1 262 ? 22.20631  15.83182 -8.06713  1.000 27.91733 ? 262 LEU   A CB  1 
ATOM   2023 C CG  . LEU   A 1 262 ? 22.02090  14.59014 -8.95667  1.000 28.77804 ? 262 LEU   A CG  1 
ATOM   2024 C CD1 . LEU   A 1 262 ? 23.08024  13.50836 -8.70933  1.000 31.72363 ? 262 LEU   A CD1 1 
ATOM   2025 C CD2 . LEU   A 1 262 ? 20.63967  14.00151 -8.68383  1.000 26.33273 ? 262 LEU   A CD2 1 
ATOM   2026 N N   . ASP   A 1 263 ? 22.07650  19.22804 -7.75245  1.000 27.85767 ? 263 ASP   A N   1 
ATOM   2027 C CA  . ASP   A 1 263 ? 22.07345  20.42954 -6.92060  1.000 29.02925 ? 263 ASP   A CA  1 
ATOM   2028 C C   . ASP   A 1 263 ? 20.69847  21.08899 -6.93678  1.000 24.29549 ? 263 ASP   A C   1 
ATOM   2029 O O   . ASP   A 1 263 ? 20.18631  21.52100 -5.89728  1.000 22.82756 ? 263 ASP   A O   1 
ATOM   2030 C CB  . ASP   A 1 263 ? 23.12294  21.41572 -7.45371  1.000 28.00113 ? 263 ASP   A CB  1 
ATOM   2031 C CG  . ASP   A 1 263 ? 24.53102  21.11912 -6.96721  1.000 42.02339 ? 263 ASP   A CG  1 
ATOM   2032 O OD1 . ASP   A 1 263 ? 25.22723  22.09751 -6.59424  1.000 53.74954 ? 263 ASP   A OD1 1 
ATOM   2033 O OD2 . ASP   A 1 263 ? 24.93406  19.92565 -6.95379  1.000 45.23923 ? 263 ASP   A OD2 1 
ATOM   2034 N N   . MET   A 1 264 ? 20.10380  21.20012 -8.12458  1.000 26.46194 ? 264 MET   A N   1 
ATOM   2035 C CA  . MET   A 1 264 ? 18.75038  21.73460 -8.23556  1.000 24.41227 ? 264 MET   A CA  1 
ATOM   2036 C C   . MET   A 1 264 ? 17.74615  20.82461 -7.53479  1.000 25.07189 ? 264 MET   A C   1 
ATOM   2037 O O   . MET   A 1 264 ? 16.78167  21.30914 -6.92603  1.000 23.58676 ? 264 MET   A O   1 
ATOM   2038 C CB  . MET   A 1 264 ? 18.36839  21.91022 -9.70855  1.000 25.17066 ? 264 MET   A CB  1 
ATOM   2039 C CG  . MET   A 1 264 ? 17.13071  22.79012 -9.90137  1.000 25.77313 ? 264 MET   A CG  1 
ATOM   2040 S SD  . MET   A 1 264 ? 17.32235  24.49635 -9.27993  1.000 22.60372 ? 264 MET   A SD  1 
ATOM   2041 C CE  . MET   A 1 264 ? 18.06332  25.27357 -10.76710 1.000 17.97206 ? 264 MET   A CE  1 
ATOM   2042 N N   . CYS   A 1 265 ? 17.94623  19.49911 -7.62087  1.000 23.97567 ? 265 CYS   A N   1 
ATOM   2043 C CA  . CYS   A 1 265 ? 17.06976  18.57089 -6.89629  1.000 23.55183 ? 265 CYS   A CA  1 
ATOM   2044 C C   . CYS   A 1 265 ? 17.10530  18.82711 -5.39667  1.000 26.05978 ? 265 CYS   A C   1 
ATOM   2045 O O   . CYS   A 1 265 ? 16.07402  18.72520 -4.71117  1.000 22.07114 ? 265 CYS   A O   1 
ATOM   2046 C CB  . CYS   A 1 265 ? 17.47089  17.12487 -7.17090  1.000 24.07417 ? 265 CYS   A CB  1 
ATOM   2047 S SG  . CYS   A 1 265 ? 17.04894  16.48610 -8.82606  1.000 26.74854 ? 265 CYS   A SG  1 
ATOM   2048 N N   . ALA   A 1 266 ? 18.29383  19.14952 -4.86515  1.000 26.78556 ? 266 ALA   A N   1 
ATOM   2049 C CA  . ALA   A 1 266 ? 18.39950  19.49746 -3.45251  1.000 25.54761 ? 266 ALA   A CA  1 
ATOM   2050 C C   . ALA   A 1 266 ? 17.62187  20.76772 -3.12938  1.000 26.48192 ? 266 ALA   A C   1 
ATOM   2051 O O   . ALA   A 1 266 ? 16.97515  20.85000 -2.07710  1.000 21.10448 ? 266 ALA   A O   1 
ATOM   2052 C CB  . ALA   A 1 266 ? 19.87112  19.62395 -3.05308  1.000 24.84489 ? 266 ALA   A CB  1 
ATOM   2053 N N   . SER   A 1 267 ? 17.64203  21.77240 -4.02771  1.000 22.60782 ? 267 SER   A N   1 
ATOM   2054 C CA  . SER   A 1 267 ? 16.80692  22.95134 -3.79661  1.000 26.85397 ? 267 SER   A CA  1 
ATOM   2055 C C   . SER   A 1 267 ? 15.32256  22.60827 -3.82517  1.000 23.38675 ? 267 SER   A C   1 
ATOM   2056 O O   . SER   A 1 267 ? 14.53669  23.14470 -3.02597  1.000 25.80038 ? 267 SER   A O   1 
ATOM   2057 C CB  . SER   A 1 267 ? 17.11070  24.05228 -4.81897  1.000 25.28789 ? 267 SER   A CB  1 
ATOM   2058 O OG  . SER   A 1 267 ? 18.47080  24.44086 -4.73919  1.000 31.70360 ? 267 SER   A OG  1 
ATOM   2059 N N   . LEU   A 1 268 ? 14.90415  21.74829 -4.75447  1.000 22.85514 ? 268 LEU   A N   1 
ATOM   2060 C CA  . LEU   A 1 268 ? 13.48584  21.38522 -4.79381  1.000 20.13428 ? 268 LEU   A CA  1 
ATOM   2061 C C   . LEU   A 1 268 ? 13.09332  20.58948 -3.56129  1.000 20.33757 ? 268 LEU   A C   1 
ATOM   2062 O O   . LEU   A 1 268 ? 11.98201  20.75435 -3.04464  1.000 23.56441 ? 268 LEU   A O   1 
ATOM   2063 C CB  . LEU   A 1 268 ? 13.16334  20.58305 -6.05385  1.000 17.60613 ? 268 LEU   A CB  1 
ATOM   2064 C CG  . LEU   A 1 268 ? 11.76214  19.98391 -6.20745  1.000 16.62621 ? 268 LEU   A CG  1 
ATOM   2065 C CD1 . LEU   A 1 268 ? 10.63532  20.98396 -6.00725  1.000 19.12336 ? 268 LEU   A CD1 1 
ATOM   2066 C CD2 . LEU   A 1 268 ? 11.64330  19.33452 -7.57166  1.000 13.75183 ? 268 LEU   A CD2 1 
ATOM   2067 N N   . LYS   A 1 269 ? 13.98412  19.71475 -3.08935  1.000 23.71822 ? 269 LYS   A N   1 
ATOM   2068 C CA  . LYS   A 1 269 ? 13.69878  18.97022 -1.85782  1.000 27.39073 ? 269 LYS   A CA  1 
ATOM   2069 C C   . LYS   A 1 269 ? 13.43136  19.92105 -0.69093  1.000 24.56962 ? 269 LYS   A C   1 
ATOM   2070 O O   . LYS   A 1 269 ? 12.45918  19.74279 0.06026   1.000 23.63145 ? 269 LYS   A O   1 
ATOM   2071 C CB  . LYS   A 1 269 ? 14.85427  18.00365 -1.56239  1.000 27.23401 ? 269 LYS   A CB  1 
ATOM   2072 C CG  . LYS   A 1 269 ? 14.81627  17.35041 -0.16901  1.000 33.75722 ? 269 LYS   A CG  1 
ATOM   2073 C CD  . LYS   A 1 269 ? 16.20534  16.92529 0.33222   1.000 42.13036 ? 269 LYS   A CD  1 
ATOM   2074 C CE  . LYS   A 1 269 ? 16.69806  15.70617 -0.48226  1.000 40.21629 ? 269 LYS   A CE  1 
ATOM   2075 N NZ  . LYS   A 1 269 ? 18.01978  15.11185 -0.07335  1.000 38.14126 ? 269 LYS   A NZ  1 
ATOM   2076 N N   . GLU   A 1 270 ? 14.24431  20.97915 -0.56768  1.000 26.61470 ? 270 GLU   A N   1 
ATOM   2077 C CA  . GLU   A 1 270 ? 14.04920  21.97300 0.49139   1.000 29.77383 ? 270 GLU   A CA  1 
ATOM   2078 C C   . GLU   A 1 270 ? 12.73272  22.74407 0.33361   1.000 31.02141 ? 270 GLU   A C   1 
ATOM   2079 O O   . GLU   A 1 270 ? 12.06675  23.04878 1.33188   1.000 32.03378 ? 270 GLU   A O   1 
ATOM   2080 C CB  . GLU   A 1 270 ? 15.24775  22.93791 0.52934   1.000 31.68511 ? 270 GLU   A CB  1 
ATOM   2081 C CG  . GLU   A 1 270 ? 15.10320  24.11638 1.53187   1.000 37.00856 ? 270 GLU   A CG  1 
ATOM   2082 C CD  . GLU   A 1 270 ? 16.44019  24.75221 1.97033   1.000 46.32110 ? 270 GLU   A CD  1 
ATOM   2083 O OE1 . GLU   A 1 270 ? 17.47290  24.58419 1.27839   1.000 43.38891 ? 270 GLU   A OE1 1 
ATOM   2084 O OE2 . GLU   A 1 270 ? 16.43984  25.47193 2.99395   1.000 57.01962 ? 270 GLU   A OE2 1 
ATOM   2085 N N   . LEU   A 1 271 ? 12.35284  23.10420 -0.90388  1.000 26.97038 ? 271 LEU   A N   1 
ATOM   2086 C CA  . LEU   A 1 271 ? 11.09494  23.82211 -1.12336  1.000 25.78009 ? 271 LEU   A CA  1 
ATOM   2087 C C   . LEU   A 1 271 ? 9.88749   22.95499 -0.78922  1.000 29.73002 ? 271 LEU   A C   1 
ATOM   2088 O O   . LEU   A 1 271 ? 8.85628   23.47013 -0.33683  1.000 29.11684 ? 271 LEU   A O   1 
ATOM   2089 C CB  . LEU   A 1 271 ? 10.97931  24.29269 -2.58125  1.000 21.45729 ? 271 LEU   A CB  1 
ATOM   2090 C CG  . LEU   A 1 271 ? 11.78757  25.50066 -3.04198  1.000 22.57644 ? 271 LEU   A CG  1 
ATOM   2091 C CD1 . LEU   A 1 271 ? 11.70681  25.60264 -4.55357  1.000 20.52084 ? 271 LEU   A CD1 1 
ATOM   2092 C CD2 . LEU   A 1 271 ? 11.24882  26.76042 -2.38505  1.000 26.90743 ? 271 LEU   A CD2 1 
ATOM   2093 N N   . LEU   A 1 272 ? 9.96992   21.64772 -1.06077  1.000 25.30962 ? 272 LEU   A N   1 
ATOM   2094 C CA  . LEU   A 1 272 ? 8.84592   20.77416 -0.72781  1.000 30.35834 ? 272 LEU   A CA  1 
ATOM   2095 C C   . LEU   A 1 272 ? 8.64486   20.67834 0.77713   1.000 29.98675 ? 272 LEU   A C   1 
ATOM   2096 O O   . LEU   A 1 272 ? 7.51152   20.73564 1.26209   1.000 32.70945 ? 272 LEU   A O   1 
ATOM   2097 C CB  . LEU   A 1 272 ? 9.05848   19.38227 -1.31559  1.000 24.76837 ? 272 LEU   A CB  1 
ATOM   2098 C CG  . LEU   A 1 272 ? 8.96110   19.36588 -2.85089  1.000 23.13123 ? 272 LEU   A CG  1 
ATOM   2099 C CD1 . LEU   A 1 272 ? 9.21857   17.97368 -3.38057  1.000 26.69450 ? 272 LEU   A CD1 1 
ATOM   2100 C CD2 . LEU   A 1 272 ? 7.62194   19.87209 -3.31629  1.000 24.93694 ? 272 LEU   A CD2 1 
ATOM   2101 N N   . GLN   A 1 273 ? 9.72255   20.51363 1.53346   1.000 32.33632 ? 273 GLN   A N   1 
ATOM   2102 C CA  . GLN   A 1 273 ? 9.53205   20.27602 2.95598   1.000 37.77885 ? 273 GLN   A CA  1 
ATOM   2103 C C   . GLN   A 1 273 ? 9.38676   21.56389 3.75502   1.000 38.77426 ? 273 GLN   A C   1 
ATOM   2104 O O   . GLN   A 1 273 ? 8.81943   21.52509 4.84528   1.000 38.23529 ? 273 GLN   A O   1 
ATOM   2105 C CB  . GLN   A 1 273 ? 10.67867  19.41529 3.49782   1.000 38.35511 ? 273 GLN   A CB  1 
ATOM   2106 C CG  . GLN   A 1 273 ? 12.04799  19.83492 3.04697   1.000 41.32261 ? 273 GLN   A CG  1 
ATOM   2107 C CD  . GLN   A 1 273 ? 13.07597  18.73895 3.21896   1.000 41.48190 ? 273 GLN   A CD  1 
ATOM   2108 O OE1 . GLN   A 1 273 ? 12.72953  17.57988 3.47592   1.000 46.29524 ? 273 GLN   A OE1 1 
ATOM   2109 N NE2 . GLN   A 1 273 ? 14.35450  19.09247 3.05104   1.000 40.44723 ? 273 GLN   A NE2 1 
ATOM   2110 N N   . ASN   A 1 274 ? 9.83175   22.71037 3.22374   1.000 37.81123 ? 274 ASN   A N   1 
ATOM   2111 C CA  . ASN   A 1 274 ? 9.76536   23.96837 3.96303   1.000 36.88906 ? 274 ASN   A CA  1 
ATOM   2112 C C   . ASN   A 1 274 ? 8.73970   24.95112 3.43036   1.000 38.06110 ? 274 ASN   A C   1 
ATOM   2113 O O   . ASN   A 1 274 ? 8.33121   25.84807 4.17470   1.000 42.93877 ? 274 ASN   A O   1 
ATOM   2114 C CB  . ASN   A 1 274 ? 11.13217  24.67124 3.98159   1.000 35.67962 ? 274 ASN   A CB  1 
ATOM   2115 C CG  . ASN   A 1 274 ? 12.14746  23.92552 4.79103   1.000 43.34536 ? 274 ASN   A CG  1 
ATOM   2116 O OD1 . ASN   A 1 274 ? 11.79043  23.19065 5.70758   1.000 49.06375 ? 274 ASN   A OD1 1 
ATOM   2117 N ND2 . ASN   A 1 274 ? 13.42423  24.11884 4.47939   1.000 48.18999 ? 274 ASN   A ND2 1 
ATOM   2118 N N   . GLY   A 1 275 ? 8.31762   24.81329 2.17652   1.000 35.75676 ? 275 GLY   A N   1 
ATOM   2119 C CA  . GLY   A 1 275 ? 7.44729   25.79717 1.57106   1.000 35.74768 ? 275 GLY   A CA  1 
ATOM   2120 C C   . GLY   A 1 275 ? 8.21885   27.00434 1.05721   1.000 36.70587 ? 275 GLY   A C   1 
ATOM   2121 O O   . GLY   A 1 275 ? 9.45291   27.07278 1.06640   1.000 32.57461 ? 275 GLY   A O   1 
ATOM   2122 N N   . MET   A 1 276 ? 7.45319   27.97794 0.59093   1.000 36.09785 ? 276 MET   A N   1 
ATOM   2123 C CA  . MET   A 1 276 ? 8.00870   29.17488 -0.01726  1.000 39.63308 ? 276 MET   A CA  1 
ATOM   2124 C C   . MET   A 1 276 ? 8.10621   30.33503 0.96094   1.000 48.43239 ? 276 MET   A C   1 
ATOM   2125 O O   . MET   A 1 276 ? 8.87314   31.27643 0.71651   1.000 43.69746 ? 276 MET   A O   1 
ATOM   2126 C CB  . MET   A 1 276 ? 7.15909   29.55092 -1.23459  1.000 39.29907 ? 276 MET   A CB  1 
ATOM   2127 C CG  . MET   A 1 276 ? 7.92297   29.35292 -2.52526  1.000 38.06294 ? 276 MET   A CG  1 
ATOM   2128 S SD  . MET   A 1 276 ? 7.12746   29.81218 -4.06581  1.000 45.91569 ? 276 MET   A SD  1 
ATOM   2129 C CE  . MET   A 1 276 ? 6.33946   28.25313 -4.49801  1.000 30.88192 ? 276 MET   A CE  1 
ATOM   2130 N N   . ASN   A 1 277 ? 7.35907   30.27186 2.06075   1.000 48.27520 ? 277 ASN   A N   1 
ATOM   2131 C CA  . ASN   A 1 277 ? 7.46385   31.21471 3.17021   1.000 47.48636 ? 277 ASN   A CA  1 
ATOM   2132 C C   . ASN   A 1 277 ? 7.38796   32.65808 2.67510   1.000 43.59411 ? 277 ASN   A C   1 
ATOM   2133 O O   . ASN   A 1 277 ? 8.30296   33.46038 2.86707   1.000 45.01983 ? 277 ASN   A O   1 
ATOM   2134 C CB  . ASN   A 1 277 ? 8.74760   30.97620 3.97555   1.000 50.94302 ? 277 ASN   A CB  1 
ATOM   2135 C CG  . ASN   A 1 277 ? 8.58745   29.87582 5.02829   1.000 64.27429 ? 277 ASN   A CG  1 
ATOM   2136 O OD1 . ASN   A 1 277 ? 7.71225   29.00545 4.91629   1.000 59.80350 ? 277 ASN   A OD1 1 
ATOM   2137 N ND2 . ASN   A 1 277 ? 9.40636   29.93801 6.07576   1.000 65.25813 ? 277 ASN   A ND2 1 
ATOM   2138 N N   . GLY   A 1 278 ? 6.27845   32.96562 2.00350   1.000 38.52842 ? 278 GLY   A N   1 
ATOM   2139 C CA  . GLY   A 1 278 ? 5.98563   34.31456 1.57250   1.000 43.72809 ? 278 GLY   A CA  1 
ATOM   2140 C C   . GLY   A 1 278 ? 6.68667   34.78474 0.31543   1.000 47.15974 ? 278 GLY   A C   1 
ATOM   2141 O O   . GLY   A 1 278 ? 6.33285   35.85706 -0.19890  1.000 46.60743 ? 278 GLY   A O   1 
ATOM   2142 N N   . ARG   A 1 279 ? 7.67153   34.04042 -0.19337  1.000 40.63131 ? 279 ARG   A N   1 
ATOM   2143 C CA  . ARG   A 1 279 ? 8.38317   34.41125 -1.41001  1.000 35.98738 ? 279 ARG   A CA  1 
ATOM   2144 C C   . ARG   A 1 279 ? 7.68297   33.79851 -2.62914  1.000 38.07000 ? 279 ARG   A C   1 
ATOM   2145 O O   . ARG   A 1 279 ? 6.81990   32.92443 -2.50821  1.000 36.76007 ? 279 ARG   A O   1 
ATOM   2146 C CB  . ARG   A 1 279 ? 9.84775   33.95870 -1.31791  1.000 35.21085 ? 279 ARG   A CB  1 
ATOM   2147 C CG  . ARG   A 1 279 ? 10.67362  34.59278 -0.19076  1.000 39.02607 ? 279 ARG   A CG  1 
ATOM   2148 C CD  . ARG   A 1 279 ? 12.08150  35.02308 -0.63224  1.000 34.57075 ? 279 ARG   A CD  1 
ATOM   2149 N NE  . ARG   A 1 279 ? 12.09580  35.93123 -1.77773  1.000 41.90651 ? 279 ARG   A NE  1 
ATOM   2150 C CZ  . ARG   A 1 279 ? 13.17446  36.56506 -2.23078  1.000 41.99373 ? 279 ARG   A CZ  1 
ATOM   2151 N NH1 . ARG   A 1 279 ? 14.36078  36.40746 -1.66477  1.000 38.99216 ? 279 ARG   A NH1 1 
ATOM   2152 N NH2 . ARG   A 1 279 ? 13.06100  37.36788 -3.28713  1.000 47.20182 ? 279 ARG   A NH2 1 
ATOM   2153 N N   . THR   A 1 280 ? 8.03891   34.29193 -3.81476  1.000 33.09603 ? 280 THR   A N   1 
ATOM   2154 C CA  . THR   A 1 280 ? 7.52589   33.75883 -5.06759  1.000 33.37236 ? 280 THR   A CA  1 
ATOM   2155 C C   . THR   A 1 280 ? 8.68177   33.36949 -5.98142  1.000 31.77254 ? 280 THR   A C   1 
ATOM   2156 O O   . THR   A 1 280 ? 9.82401   33.78435 -5.78882  1.000 29.27781 ? 280 THR   A O   1 
ATOM   2157 C CB  . THR   A 1 280 ? 6.63129   34.76168 -5.80466  1.000 31.26547 ? 280 THR   A CB  1 
ATOM   2158 O OG1 . THR   A 1 280 ? 7.38005   35.95484 -6.08369  1.000 32.17414 ? 280 THR   A OG1 1 
ATOM   2159 C CG2 . THR   A 1 280 ? 5.42053   35.10944 -4.96037  1.000 37.37038 ? 280 THR   A CG2 1 
ATOM   2160 N N   . ILE   A 1 281 ? 8.36390   32.57292 -6.99895  1.000 28.21118 ? 281 ILE   A N   1 
ATOM   2161 C CA  . ILE   A 1 281 ? 9.32168   32.16751 -8.01856  1.000 29.81823 ? 281 ILE   A CA  1 
ATOM   2162 C C   . ILE   A 1 281 ? 8.68355   32.48652 -9.35825  1.000 27.77860 ? 281 ILE   A C   1 
ATOM   2163 O O   . ILE   A 1 281 ? 7.59505   31.98417 -9.64886  1.000 24.42542 ? 281 ILE   A O   1 
ATOM   2164 C CB  . ILE   A 1 281 ? 9.67326   30.67108 -7.90631  1.000 25.25566 ? 281 ILE   A CB  1 
ATOM   2165 C CG1 . ILE   A 1 281 ? 10.37090  30.39503 -6.57848  1.000 24.20031 ? 281 ILE   A CG1 1 
ATOM   2166 C CG2 . ILE   A 1 281 ? 10.55616  30.23743 -9.03948  1.000 20.94082 ? 281 ILE   A CG2 1 
ATOM   2167 C CD1 . ILE   A 1 281 ? 10.61486  28.92313 -6.29943  1.000 19.85418 ? 281 ILE   A CD1 1 
ATOM   2168 N N   . LEU   A 1 282 ? 9.32591   33.36328 -10.14981 1.000 25.73512 ? 282 LEU   A N   1 
ATOM   2169 C CA  . LEU   A 1 282 ? 8.74771   33.82957 -11.41010 1.000 29.87287 ? 282 LEU   A CA  1 
ATOM   2170 C C   . LEU   A 1 282 ? 7.31611   34.32735 -11.19818 1.000 30.07169 ? 282 LEU   A C   1 
ATOM   2171 O O   . LEU   A 1 282 ? 6.40063   33.97472 -11.93847 1.000 32.24589 ? 282 LEU   A O   1 
ATOM   2172 C CB  . LEU   A 1 282 ? 8.79793   32.72223 -12.46755 1.000 24.18422 ? 282 LEU   A CB  1 
ATOM   2173 C CG  . LEU   A 1 282 ? 10.21246  32.47112 -12.98480 1.000 23.94878 ? 282 LEU   A CG  1 
ATOM   2174 C CD1 . LEU   A 1 282 ? 10.25415  31.30383 -13.94116 1.000 20.73405 ? 282 LEU   A CD1 1 
ATOM   2175 C CD2 . LEU   A 1 282 ? 10.72024  33.71886 -13.71685 1.000 27.02851 ? 282 LEU   A CD2 1 
ATOM   2176 N N   . GLY   A 1 283 ? 7.10942   35.08540 -10.12315 1.000 27.99840 ? 283 GLY   A N   1 
ATOM   2177 C CA  . GLY   A 1 283 ? 5.79733   35.61973 -9.79984  1.000 33.95577 ? 283 GLY   A CA  1 
ATOM   2178 C C   . GLY   A 1 283 ? 4.78793   34.64873 -9.21557  1.000 38.39979 ? 283 GLY   A C   1 
ATOM   2179 O O   . GLY   A 1 283 ? 3.67873   35.07866 -8.87449  1.000 28.18140 ? 283 GLY   A O   1 
ATOM   2180 N N   . SER   A 1 284 ? 5.12135   33.36652 -9.07280  1.000 32.02988 ? 284 SER   A N   1 
ATOM   2181 C CA  . SER   A 1 284 ? 4.15933   32.35086 -8.66846  1.000 29.95534 ? 284 SER   A CA  1 
ATOM   2182 C C   . SER   A 1 284 ? 4.36463   31.94371 -7.21536  1.000 33.76776 ? 284 SER   A C   1 
ATOM   2183 O O   . SER   A 1 284 ? 5.49559   31.83846 -6.74248  1.000 28.68575 ? 284 SER   A O   1 
ATOM   2184 C CB  . SER   A 1 284 ? 4.27403   31.11909 -9.56716  1.000 32.52291 ? 284 SER   A CB  1 
ATOM   2185 O OG  . SER   A 1 284 ? 3.46940   30.07135 -9.07501  1.000 38.20034 ? 284 SER   A OG  1 
ATOM   2186 N N   . ALA   A 1 285 ? 3.26572   31.67378 -6.51504  1.000 36.34576 ? 285 ALA   A N   1 
ATOM   2187 C CA  . ALA   A 1 285 ? 3.34404   31.15055 -5.15588  1.000 34.24586 ? 285 ALA   A CA  1 
ATOM   2188 C C   . ALA   A 1 285 ? 3.27709   29.63010 -5.11113  1.000 34.50886 ? 285 ALA   A C   1 
ATOM   2189 O O   . ALA   A 1 285 ? 3.39348   29.04193 -4.02892  1.000 37.79323 ? 285 ALA   A O   1 
ATOM   2190 C CB  . ALA   A 1 285 ? 2.23164   31.75464 -4.28741  1.000 32.49797 ? 285 ALA   A CB  1 
ATOM   2191 N N   . LEU   A 1 286 ? 3.12858   28.98475 -6.25938  1.000 30.01836 ? 286 LEU   A N   1 
ATOM   2192 C CA  . LEU   A 1 286 ? 3.06957   27.53847 -6.37566  1.000 31.70033 ? 286 LEU   A CA  1 
ATOM   2193 C C   . LEU   A 1 286 ? 4.18307   27.10297 -7.32917  1.000 29.97928 ? 286 LEU   A C   1 
ATOM   2194 O O   . LEU   A 1 286 ? 4.64205   27.88695 -8.16442  1.000 28.12727 ? 286 LEU   A O   1 
ATOM   2195 C CB  . LEU   A 1 286 ? 1.70935   27.08579 -6.92691  1.000 35.23914 ? 286 LEU   A CB  1 
ATOM   2196 C CG  . LEU   A 1 286 ? 0.40328   27.83518 -6.59371  1.000 39.49551 ? 286 LEU   A CG  1 
ATOM   2197 C CD1 . LEU   A 1 286 ? -0.81268  27.03025 -7.06915  1.000 37.22161 ? 286 LEU   A CD1 1 
ATOM   2198 C CD2 . LEU   A 1 286 ? 0.24919   28.20392 -5.12619  1.000 43.37014 ? 286 LEU   A CD2 1 
ATOM   2199 N N   . LEU   A 1 287 ? 4.63145   25.85713 -7.19628  1.000 25.89626 ? 287 LEU   A N   1 
ATOM   2200 C CA  . LEU   A 1 287 ? 5.61928   25.32359 -8.12675  1.000 24.23141 ? 287 LEU   A CA  1 
ATOM   2201 C C   . LEU   A 1 287 ? 4.90992   24.90637 -9.40942  1.000 26.86726 ? 287 LEU   A C   1 
ATOM   2202 O O   . LEU   A 1 287 ? 3.88141   24.23381 -9.36339  1.000 29.00638 ? 287 LEU   A O   1 
ATOM   2203 C CB  . LEU   A 1 287 ? 6.36998   24.14503 -7.50226  1.000 26.55275 ? 287 LEU   A CB  1 
ATOM   2204 C CG  . LEU   A 1 287 ? 7.09409   24.45365 -6.18036  1.000 28.92795 ? 287 LEU   A CG  1 
ATOM   2205 C CD1 . LEU   A 1 287 ? 7.57783   23.20244 -5.47060  1.000 27.55264 ? 287 LEU   A CD1 1 
ATOM   2206 C CD2 . LEU   A 1 287 ? 8.24334   25.42883 -6.43213  1.000 24.63703 ? 287 LEU   A CD2 1 
ATOM   2207 N N   . GLU   A 1 288 ? 5.43859   25.32062 -10.55094 1.000 24.01965 ? 288 GLU   A N   1 
ATOM   2208 C CA  . GLU   A 1 288 ? 4.78527   25.07749 -11.83113 1.000 23.42812 ? 288 GLU   A CA  1 
ATOM   2209 C C   . GLU   A 1 288 ? 5.43253   23.91218 -12.55877 1.000 20.52141 ? 288 GLU   A C   1 
ATOM   2210 O O   . GLU   A 1 288 ? 6.66538   23.78180 -12.56436 1.000 18.64612 ? 288 GLU   A O   1 
ATOM   2211 C CB  . GLU   A 1 288 ? 4.83487   26.33080 -12.70722 1.000 25.09712 ? 288 GLU   A CB  1 
ATOM   2212 C CG  . GLU   A 1 288 ? 4.29663   27.51861 -11.97140 1.000 34.88715 ? 288 GLU   A CG  1 
ATOM   2213 C CD  . GLU   A 1 288 ? 3.27816   28.26440 -12.77657 1.000 48.29723 ? 288 GLU   A CD  1 
ATOM   2214 O OE1 . GLU   A 1 288 ? 2.46162   28.98043 -12.14939 1.000 51.72557 ? 288 GLU   A OE1 1 
ATOM   2215 O OE2 . GLU   A 1 288 ? 3.30983   28.14200 -14.02661 1.000 49.48934 ? 288 GLU   A OE2 1 
ATOM   2216 N N   . ASP   A 1 289 ? 4.58556   23.04319 -13.15119 1.000 19.88583 ? 289 ASP   A N   1 
ATOM   2217 C CA  . ASP   A 1 289 ? 5.06188   21.82661 -13.81008 1.000 21.76197 ? 289 ASP   A CA  1 
ATOM   2218 C C   . ASP   A 1 289 ? 4.56049   21.69459 -15.24681 1.000 22.38762 ? 289 ASP   A C   1 
ATOM   2219 O O   . ASP   A 1 289 ? 4.52598   20.57994 -15.78380 1.000 22.10419 ? 289 ASP   A O   1 
ATOM   2220 C CB  . ASP   A 1 289 ? 4.68973   20.57809 -12.98540 1.000 22.01743 ? 289 ASP   A CB  1 
ATOM   2221 C CG  . ASP   A 1 289 ? 3.20191   20.17996 -13.08921 1.000 26.51754 ? 289 ASP   A CG  1 
ATOM   2222 O OD1 . ASP   A 1 289 ? 2.33201   20.99736 -13.50640 1.000 23.59648 ? 289 ASP   A OD1 1 
ATOM   2223 O OD2 . ASP   A 1 289 ? 2.90131   19.02036 -12.72326 1.000 25.64060 ? 289 ASP   A OD2 1 
ATOM   2224 N N   . GLU   A 1 290 ? 4.17483   22.80046 -15.88296 1.000 21.77715 ? 290 GLU   A N   1 
ATOM   2225 C CA  . GLU   A 1 290 ? 3.63786   22.77881 -17.24532 1.000 23.72681 ? 290 GLU   A CA  1 
ATOM   2226 C C   . GLU   A 1 290 ? 4.67311   23.23211 -18.29058 1.000 26.01772 ? 290 GLU   A C   1 
ATOM   2227 O O   . GLU   A 1 290 ? 4.30944   23.44244 -19.45660 1.000 25.33921 ? 290 GLU   A O   1 
ATOM   2228 C CB  . GLU   A 1 290 ? 2.34717   23.63767 -17.29580 1.000 32.13969 ? 290 GLU   A CB  1 
ATOM   2229 C CG  . GLU   A 1 290 ? 1.11110   22.92425 -16.57230 1.000 30.70934 ? 290 GLU   A CG  1 
ATOM   2230 C CD  . GLU   A 1 290 ? -0.06060  22.42148 -17.46433 1.000 36.66438 ? 290 GLU   A CD  1 
ATOM   2231 O OE1 . GLU   A 1 290 ? -0.98373  21.76301 -16.90881 1.000 25.27743 ? 290 GLU   A OE1 1 
ATOM   2232 O OE2 . GLU   A 1 290 ? -0.16903  22.82880 -18.65991 1.000 30.76216 ? 290 GLU   A OE2 1 
ATOM   2233 N N   . PHE   A 1 291 ? 5.95695   23.37624 -17.91197 1.000 18.26883 ? 291 PHE   A N   1 
ATOM   2234 C CA  . PHE   A 1 291 ? 7.04690   23.60054 -18.87499 1.000 19.65178 ? 291 PHE   A CA  1 
ATOM   2235 C C   . PHE   A 1 291 ? 7.99532   22.40515 -18.91475 1.000 21.44717 ? 291 PHE   A C   1 
ATOM   2236 O O   . PHE   A 1 291 ? 8.52460   21.98816 -17.87431 1.000 20.81521 ? 291 PHE   A O   1 
ATOM   2237 C CB  . PHE   A 1 291 ? 7.89436   24.85537 -18.57230 1.000 19.16399 ? 291 PHE   A CB  1 
ATOM   2238 C CG  . PHE   A 1 291 ? 7.11124   26.12154 -18.40774 1.000 23.73610 ? 291 PHE   A CG  1 
ATOM   2239 C CD1 . PHE   A 1 291 ? 6.51285   26.43550 -17.19714 1.000 26.45525 ? 291 PHE   A CD1 1 
ATOM   2240 C CD2 . PHE   A 1 291 ? 6.93692   26.98559 -19.49572 1.000 22.90361 ? 291 PHE   A CD2 1 
ATOM   2241 C CE1 . PHE   A 1 291 ? 5.76979   27.62574 -17.04930 1.000 32.49471 ? 291 PHE   A CE1 1 
ATOM   2242 C CE2 . PHE   A 1 291 ? 6.20243   28.17368 -19.36282 1.000 29.53646 ? 291 PHE   A CE2 1 
ATOM   2243 C CZ  . PHE   A 1 291 ? 5.61811   28.49308 -18.13928 1.000 29.93329 ? 291 PHE   A CZ  1 
ATOM   2244 N N   . THR   A 1 292 ? 8.25455   21.88274 -20.11590 1.000 17.64870 ? 292 THR   A N   1 
ATOM   2245 C CA  . THR   A 1 292 ? 9.25704   20.83109 -20.25917 1.000 18.46997 ? 292 THR   A CA  1 
ATOM   2246 C C   . THR   A 1 292 ? 10.67804  21.39360 -20.31188 1.000 20.03625 ? 292 THR   A C   1 
ATOM   2247 O O   . THR   A 1 292 ? 10.88069  22.57176 -20.59480 1.000 20.62317 ? 292 THR   A O   1 
ATOM   2248 C CB  . THR   A 1 292 ? 9.03029   20.04018 -21.53462 1.000 20.06651 ? 292 THR   A CB  1 
ATOM   2249 O OG1 . THR   A 1 292 ? 9.35402   20.91313 -22.61973 1.000 18.95346 ? 292 THR   A OG1 1 
ATOM   2250 C CG2 . THR   A 1 292 ? 7.57268   19.53180 -21.62531 1.000 19.59809 ? 292 THR   A CG2 1 
ATOM   2251 N N   . PRO   A 1 293 ? 11.68500  20.54879 -20.06726 1.000 20.85379 ? 293 PRO   A N   1 
ATOM   2252 C CA  . PRO   A 1 293 ? 13.07317  20.97472 -20.30119 1.000 19.83055 ? 293 PRO   A CA  1 
ATOM   2253 C C   . PRO   A 1 293 ? 13.28225  21.56990 -21.68036 1.000 24.22964 ? 293 PRO   A C   1 
ATOM   2254 O O   . PRO   A 1 293 ? 14.00433  22.56562 -21.82228 1.000 22.39884 ? 293 PRO   A O   1 
ATOM   2255 C CB  . PRO   A 1 293 ? 13.86072  19.67015 -20.11857 1.000 22.11877 ? 293 PRO   A CB  1 
ATOM   2256 C CG  . PRO   A 1 293 ? 13.04876  18.92671 -19.07286 1.000 22.50607 ? 293 PRO   A CG  1 
ATOM   2257 C CD  . PRO   A 1 293 ? 11.60818  19.26308 -19.34438 1.000 22.05732 ? 293 PRO   A CD  1 
ATOM   2258 N N   . PHE   A 1 294 ? 12.66230  20.98926 -22.71339 1.000 21.60737 ? 294 PHE   A N   1 
ATOM   2259 C CA  . PHE   A 1 294 ? 12.85194  21.57978 -24.03584 1.000 24.78482 ? 294 PHE   A CA  1 
ATOM   2260 C C   . PHE   A 1 294 ? 12.15107  22.93125 -24.17314 1.000 27.13887 ? 294 PHE   A C   1 
ATOM   2261 O O   . PHE   A 1 294 ? 12.68267  23.82677 -24.84658 1.000 25.99834 ? 294 PHE   A O   1 
ATOM   2262 C CB  . PHE   A 1 294 ? 12.39972  20.63150 -25.14328 1.000 30.70931 ? 294 PHE   A CB  1 
ATOM   2263 C CG  . PHE   A 1 294 ? 12.64550  21.19550 -26.51355 1.000 40.62808 ? 294 PHE   A CG  1 
ATOM   2264 C CD1 . PHE   A 1 294 ? 13.93897  21.31618 -26.99441 1.000 42.44965 ? 294 PHE   A CD1 1 
ATOM   2265 C CD2 . PHE   A 1 294 ? 11.58942  21.67581 -27.28795 1.000 44.93718 ? 294 PHE   A CD2 1 
ATOM   2266 C CE1 . PHE   A 1 294 ? 14.18200  21.86069 -28.24702 1.000 46.83422 ? 294 PHE   A CE1 1 
ATOM   2267 C CE2 . PHE   A 1 294 ? 11.81843  22.23572 -28.54124 1.000 45.39017 ? 294 PHE   A CE2 1 
ATOM   2268 C CZ  . PHE   A 1 294 ? 13.12076  22.32202 -29.02475 1.000 51.40875 ? 294 PHE   A CZ  1 
ATOM   2269 N N   . ASP   A 1 295 ? 10.97704  23.10878 -23.54429 1.000 20.23061 ? 295 ASP   A N   1 
ATOM   2270 C CA  . ASP   A 1 295 ? 10.31266  24.41111 -23.54489 1.000 23.31323 ? 295 ASP   A CA  1 
ATOM   2271 C C   . ASP   A 1 295 ? 11.22349  25.50475 -22.99914 1.000 23.59349 ? 295 ASP   A C   1 
ATOM   2272 O O   . ASP   A 1 295 ? 11.21264  26.63536 -23.49626 1.000 20.63475 ? 295 ASP   A O   1 
ATOM   2273 C CB  . ASP   A 1 295 ? 9.03812   24.39170 -22.69226 1.000 20.98136 ? 295 ASP   A CB  1 
ATOM   2274 C CG  . ASP   A 1 295 ? 7.93993   23.52745 -23.28043 1.000 27.39858 ? 295 ASP   A CG  1 
ATOM   2275 O OD1 . ASP   A 1 295 ? 7.99599   23.25000 -24.49496 1.000 29.72721 ? 295 ASP   A OD1 1 
ATOM   2276 O OD2 . ASP   A 1 295 ? 7.01658   23.15141 -22.51224 1.000 22.50141 ? 295 ASP   A OD2 1 
ATOM   2277 N N   . VAL   A 1 296 ? 11.95435  25.21039 -21.92468 1.000 19.03241 ? 296 VAL   A N   1 
ATOM   2278 C CA  . VAL   A 1 296 ? 12.83076  26.21302 -21.32086 1.000 17.74794 ? 296 VAL   A CA  1 
ATOM   2279 C C   . VAL   A 1 296 ? 14.01549  26.50916 -22.23670 1.000 22.75421 ? 296 VAL   A C   1 
ATOM   2280 O O   . VAL   A 1 296 ? 14.39082  27.67231 -22.43030 1.000 24.25262 ? 296 VAL   A O   1 
ATOM   2281 C CB  . VAL   A 1 296 ? 13.30590  25.73583 -19.93251 1.000 20.84473 ? 296 VAL   A CB  1 
ATOM   2282 C CG1 . VAL   A 1 296 ? 14.35268  26.68757 -19.34821 1.000 21.50407 ? 296 VAL   A CG1 1 
ATOM   2283 C CG2 . VAL   A 1 296 ? 12.13152  25.57276 -18.98943 1.000 17.90307 ? 296 VAL   A CG2 1 
ATOM   2284 N N   . VAL   A 1 297 ? 14.62343  25.46772 -22.80488 1.000 22.87614 ? 297 VAL   A N   1 
ATOM   2285 C CA  . VAL   A 1 297 ? 15.78294  25.65921 -23.67716 1.000 25.90038 ? 297 VAL   A CA  1 
ATOM   2286 C C   . VAL   A 1 297 ? 15.39572  26.46085 -24.91943 1.000 27.58603 ? 297 VAL   A C   1 
ATOM   2287 O O   . VAL   A 1 297 ? 16.10287  27.39438 -25.32357 1.000 27.89259 ? 297 VAL   A O   1 
ATOM   2288 C CB  . VAL   A 1 297 ? 16.40565  24.29986 -24.05051 1.000 30.76076 ? 297 VAL   A CB  1 
ATOM   2289 C CG1 . VAL   A 1 297 ? 17.48601  24.47683 -25.13064 1.000 28.40079 ? 297 VAL   A CG1 1 
ATOM   2290 C CG2 . VAL   A 1 297 ? 17.01035  23.65319 -22.82612 1.000 27.48390 ? 297 VAL   A CG2 1 
ATOM   2291 N N   . ARG   A 1 298 ? 14.27068  26.10500 -25.53964 1.000 26.58998 ? 298 ARG   A N   1 
ATOM   2292 C CA  . ARG   A 1 298 ? 13.78582  26.80287 -26.72861 1.000 31.17157 ? 298 ARG   A CA  1 
ATOM   2293 C C   . ARG   A 1 298 ? 13.56648  28.28946 -26.44469 1.000 29.90596 ? 298 ARG   A C   1 
ATOM   2294 O O   . ARG   A 1 298 ? 13.99828  29.15936 -27.21858 1.000 31.33051 ? 298 ARG   A O   1 
ATOM   2295 C CB  . ARG   A 1 298 ? 12.50364  26.10324 -27.19922 1.000 33.66986 ? 298 ARG   A CB  1 
ATOM   2296 C CG  . ARG   A 1 298 ? 11.63291  26.82536 -28.18778 1.000 42.80396 ? 298 ARG   A CG  1 
ATOM   2297 C CD  . ARG   A 1 298 ? 10.15640  26.43190 -28.02496 1.000 38.30654 ? 298 ARG   A CD  1 
ATOM   2298 N NE  . ARG   A 1 298 ? 9.32274   27.51818 -28.52707 1.000 40.40624 ? 298 ARG   A NE  1 
ATOM   2299 C CZ  . ARG   A 1 298 ? 8.04934   27.74037 -28.21902 1.000 36.10903 ? 298 ARG   A CZ  1 
ATOM   2300 N NH1 . ARG   A 1 298 ? 7.39711   26.98893 -27.34098 1.000 35.60483 ? 298 ARG   A NH1 1 
ATOM   2301 N NH2 . ARG   A 1 298 ? 7.41878   28.76023 -28.79725 1.000 30.24185 ? 298 ARG   A NH2 1 
ATOM   2302 N N   . GLN   A 1 299 ? 12.93767  28.60039 -25.31003 1.000 23.79264 ? 299 GLN   A N   1 
ATOM   2303 C CA  . GLN   A 1 299 ? 12.69033  29.99055 -24.95038 1.000 29.00122 ? 299 GLN   A CA  1 
ATOM   2304 C C   . GLN   A 1 299 ? 13.98130  30.70948 -24.55350 1.000 31.85586 ? 299 GLN   A C   1 
ATOM   2305 O O   . GLN   A 1 299 ? 14.21089  31.85543 -24.95892 1.000 32.82961 ? 299 GLN   A O   1 
ATOM   2306 C CB  . GLN   A 1 299 ? 11.66586  30.07638 -23.81174 1.000 21.93432 ? 299 GLN   A CB  1 
ATOM   2307 C CG  . GLN   A 1 299 ? 11.31379  31.53793 -23.46437 1.000 22.39996 ? 299 GLN   A CG  1 
ATOM   2308 C CD  . GLN   A 1 299 ? 10.04323  31.68251 -22.65161 1.000 24.55577 ? 299 GLN   A CD  1 
ATOM   2309 O OE1 . GLN   A 1 299 ? 9.76809   32.75109 -22.10488 1.000 24.16268 ? 299 GLN   A OE1 1 
ATOM   2310 N NE2 . GLN   A 1 299 ? 9.23931   30.61331 -22.59226 1.000 24.43854 ? 299 GLN   A NE2 1 
ATOM   2311 N N   . CYS   A 1 300 ? 14.84075  30.06103 -23.77122 1.000 28.54634 ? 300 CYS   A N   1 
ATOM   2312 C CA  . CYS   A 1 300 ? 16.00439  30.77038 -23.25239 1.000 26.40450 ? 300 CYS   A CA  1 
ATOM   2313 C C   . CYS   A 1 300 ? 17.14608  30.83671 -24.25729 1.000 31.48778 ? 300 CYS   A C   1 
ATOM   2314 O O   . CYS   A 1 300 ? 18.10639  31.57146 -24.02211 1.000 33.32324 ? 300 CYS   A O   1 
ATOM   2315 C CB  . CYS   A 1 300 ? 16.44842  30.13280 -21.91048 1.000 25.76881 ? 300 CYS   A CB  1 
ATOM   2316 S SG  . CYS   A 1 300 ? 15.18906  30.42536 -20.60282 1.000 39.30481 ? 300 CYS   A SG  1 
ATOM   2317 N N   . SER   A 1 301 ? 17.04683  30.14644 -25.39097 1.000 31.69399 ? 301 SER   A N   1 
ATOM   2318 C CA  . SER   A 1 301 ? 18.10251  30.20336 -26.41005 1.000 33.26557 ? 301 SER   A CA  1 
ATOM   2319 C C   . SER   A 1 301 ? 17.58398  30.86003 -27.67621 1.000 37.10595 ? 301 SER   A C   1 
ATOM   2320 O O   . SER   A 1 301 ? 18.23030  30.83807 -28.73322 1.000 36.01264 ? 301 SER   A O   1 
ATOM   2321 C CB  . SER   A 1 301 ? 18.63045  28.80857 -26.73168 1.000 34.30549 ? 301 SER   A CB  1 
ATOM   2322 O OG  . SER   A 1 301 ? 17.62171  28.01203 -27.31940 1.000 36.94778 ? 301 SER   A OG  1 
HETATM 2323 N N   . GLY   B 2 .   ? 14.99000  31.82884 -28.25014 1.000 39.73530 ? 401 GLY   A N   1 
HETATM 2324 C CA  . GLY   B 2 .   ? 15.51347  32.26266 -29.53232 1.000 37.51652 ? 401 GLY   A CA  1 
HETATM 2325 C C   . GLY   B 2 .   ? 15.50776  31.19650 -30.60993 1.000 33.79333 ? 401 GLY   A C   1 
HETATM 2326 O O   . GLY   B 2 .   ? 15.86802  31.49367 -31.74503 1.000 34.43152 ? 401 GLY   A O   1 
HETATM 2327 N N   . VAL   C 3 .   ? 15.13238  29.95903 -30.27367 1.000 32.37849 ? 402 VAL   A N   1 
HETATM 2328 C CA  . VAL   C 3 .   ? 14.87397  28.96730 -31.32030 1.000 33.57629 ? 402 VAL   A CA  1 
HETATM 2329 C C   . VAL   C 3 .   ? 13.68011  29.43007 -32.15211 1.000 35.89070 ? 402 VAL   A C   1 
HETATM 2330 O O   . VAL   C 3 .   ? 12.60425  29.71153 -31.61282 1.000 36.25964 ? 402 VAL   A O   1 
HETATM 2331 C CB  . VAL   C 3 .   ? 14.62609  27.56731 -30.73810 1.000 32.91056 ? 402 VAL   A CB  1 
HETATM 2332 C CG1 . VAL   C 3 .   ? 14.37058  26.57241 -31.86603 1.000 34.98718 ? 402 VAL   A CG1 1 
HETATM 2333 C CG2 . VAL   C 3 .   ? 15.83355  27.08146 -29.92337 1.000 31.12570 ? 402 VAL   A CG2 1 
HETATM 2334 N N   . THR   D 4 .   ? 13.86933  29.50530 -33.46911 1.000 35.73135 ? 403 THR   A N   1 
HETATM 2335 C CA  . THR   D 4 .   ? 12.86565  29.96529 -34.42283 1.000 35.40130 ? 403 THR   A CA  1 
HETATM 2336 C C   . THR   D 4 .   ? 12.45538  28.82672 -35.35127 1.000 36.69921 ? 403 THR   A C   1 
HETATM 2337 O O   . THR   D 4 .   ? 13.02622  27.73330 -35.32255 1.000 37.17325 ? 403 THR   A O   1 
HETATM 2338 C CB  . THR   D 4 .   ? 13.40213  31.14954 -35.24171 1.000 34.77006 ? 403 THR   A CB  1 
HETATM 2339 O OG1 . THR   D 4 .   ? 14.53635  30.73206 -36.01771 1.000 33.12160 ? 403 THR   A OG1 1 
HETATM 2340 C CG2 . THR   D 4 .   ? 13.81010  32.29113 -34.31966 1.000 29.55988 ? 403 THR   A CG2 1 
HETATM 2341 N N   . PHE   E 5 .   ? 11.46112  29.09403 -36.19949 1.000 30.85194 ? 404 PHE   A N   1 
HETATM 2342 C CA  . PHE   E 5 .   ? 10.94758  28.02956 -37.06575 1.000 35.97456 ? 404 PHE   A CA  1 
HETATM 2343 C C   . PHE   E 5 .   ? 10.74608  28.43067 -38.53145 1.000 37.10347 ? 404 PHE   A C   1 
HETATM 2344 O O   . PHE   E 5 .   ? 10.33542  29.54706 -38.82873 1.000 46.98912 ? 404 PHE   A O   1 
HETATM 2345 C CB  . PHE   E 5 .   ? 9.64149   27.47433 -36.46795 1.000 37.12829 ? 404 PHE   A CB  1 
HETATM 2346 C CG  . PHE   E 5 .   ? 9.74199   27.18664 -34.98393 1.000 35.96177 ? 404 PHE   A CG  1 
HETATM 2347 C CD1 . PHE   E 5 .   ? 10.19205  25.94914 -34.53892 1.000 34.63249 ? 404 PHE   A CD1 1 
HETATM 2348 C CD2 . PHE   E 5 .   ? 9.41412   28.15862 -34.03922 1.000 36.55723 ? 404 PHE   A CD2 1 
HETATM 2349 C CE1 . PHE   E 5 .   ? 10.30992  25.67410 -33.18546 1.000 36.56908 ? 404 PHE   A CE1 1 
HETATM 2350 C CE2 . PHE   E 5 .   ? 9.53883   27.89018 -32.67160 1.000 34.20871 ? 404 PHE   A CE2 1 
HETATM 2351 C CZ  . PHE   E 5 .   ? 9.98513   26.64695 -32.25134 1.000 36.36847 ? 404 PHE   A CZ  1 
HETATM 2352 C C13 . A1ALW F 6 .   ? -18.80135 16.53696 -26.33827 1.000 25.19656 ? 405 A1ALW A C13 1 
HETATM 2353 C C15 . A1ALW F 6 .   ? -19.65948 14.24929 -27.02914 1.000 27.94385 ? 405 A1ALW A C15 1 
HETATM 2354 C C17 . A1ALW F 6 .   ? -18.24363 13.72299 -27.05612 1.000 27.59244 ? 405 A1ALW A C17 1 
HETATM 2355 C C20 . A1ALW F 6 .   ? -19.56466 16.73151 -22.48955 1.000 24.53216 ? 405 A1ALW A C20 1 
HETATM 2356 C C21 . A1ALW F 6 .   ? -19.69711 17.76228 -21.53002 1.000 23.86929 ? 405 A1ALW A C21 1 
HETATM 2357 C C22 . A1ALW F 6 .   ? -20.28217 17.43882 -20.30788 1.000 24.43338 ? 405 A1ALW A C22 1 
HETATM 2358 C C24 . A1ALW F 6 .   ? -21.33659 15.79152 -18.64494 1.000 24.94250 ? 405 A1ALW A C24 1 
HETATM 2359 C C02 . A1ALW F 6 .   ? -16.24119 20.96594 -24.36154 1.000 29.82163 ? 405 A1ALW A C02 1 
HETATM 2360 C C04 . A1ALW F 6 .   ? -18.16038 22.31961 -23.88196 1.000 26.97506 ? 405 A1ALW A C04 1 
HETATM 2361 C C05 . A1ALW F 6 .   ? -18.27079 21.66219 -25.35222 1.000 26.66731 ? 405 A1ALW A C05 1 
HETATM 2362 C C06 . A1ALW F 6 .   ? -17.04707 20.67871 -25.44485 1.000 24.62242 ? 405 A1ALW A C06 1 
HETATM 2363 C C07 . A1ALW F 6 .   ? -16.42078 20.65023 -26.95354 1.000 24.65644 ? 405 A1ALW A C07 1 
HETATM 2364 C C08 . A1ALW F 6 .   ? -17.40415 19.89409 -27.89861 1.000 26.73317 ? 405 A1ALW A C08 1 
HETATM 2365 C C09 . A1ALW F 6 .   ? -16.91349 19.87319 -29.35871 1.000 22.67484 ? 405 A1ALW A C09 1 
HETATM 2366 C C12 . A1ALW F 6 .   ? -18.72608 18.01999 -26.72991 1.000 24.27718 ? 405 A1ALW A C12 1 
HETATM 2367 C C14 . A1ALW F 6 .   ? -19.63295 15.74302 -27.37064 1.000 24.64414 ? 405 A1ALW A C14 1 
HETATM 2368 C C16 . A1ALW F 6 .   ? -20.51993 13.47207 -28.04975 1.000 29.52701 ? 405 A1ALW A C16 1 
HETATM 2369 C C19 . A1ALW F 6 .   ? -18.89869 16.98051 -23.86500 1.000 25.51904 ? 405 A1ALW A C19 1 
HETATM 2370 C C23 . A1ALW F 6 .   ? -20.72478 16.13230 -20.03149 1.000 24.82848 ? 405 A1ALW A C23 1 
HETATM 2371 C C25 . A1ALW F 6 .   ? -20.96326 16.57553 -17.57003 1.000 27.09275 ? 405 A1ALW A C25 1 
HETATM 2372 C C27 . A1ALW F 6 .   ? -22.24039 15.33227 -16.14743 1.000 26.84898 ? 405 A1ALW A C27 1 
HETATM 2373 C C29 . A1ALW F 6 .   ? -22.63833 14.45716 -17.15963 1.000 26.47883 ? 405 A1ALW A C29 1 
HETATM 2374 C C30 . A1ALW F 6 .   ? -22.17663 14.67747 -18.46202 1.000 28.77419 ? 405 A1ALW A C30 1 
HETATM 2375 C C31 . A1ALW F 6 .   ? -20.57109 15.11434 -20.96816 1.000 26.91721 ? 405 A1ALW A C31 1 
HETATM 2376 C C32 . A1ALW F 6 .   ? -19.98786 15.44042 -22.21405 1.000 24.77254 ? 405 A1ALW A C32 1 
HETATM 2377 F F28 . A1ALW F 6 .   ? -22.67184 15.12075 -14.87521 1.000 28.66738 ? 405 A1ALW A F28 1 
HETATM 2378 N N03 . A1ALW F 6 .   ? -16.86362 22.30524 -23.61585 1.000 27.20301 ? 405 A1ALW A N03 1 
HETATM 2379 N N10 . A1ALW F 6 .   ? -17.61764 20.86787 -30.17539 1.000 27.05730 ? 405 A1ALW A N10 1 
HETATM 2380 N N11 . A1ALW F 6 .   ? -17.52947 18.49039 -27.48930 1.000 27.82738 ? 405 A1ALW A N11 1 
HETATM 2381 N N18 . A1ALW F 6 .   ? -19.44939 16.33331 -25.06254 1.000 25.11447 ? 405 A1ALW A N18 1 
HETATM 2382 N N26 . A1ALW F 6 .   ? -21.43472 16.35716 -16.34495 1.000 26.54807 ? 405 A1ALW A N26 1 
HETATM 2383 O O01 . A1ALW F 6 .   ? -14.90952 21.17933 -24.53747 1.000 23.40935 ? 405 A1ALW A O01 1 
HETATM 2384 O O33 . A1ALW F 6 .   ? -17.92580 17.65259 -23.98989 1.000 22.39880 ? 405 A1ALW A O33 1 
HETATM 2385 O O34 . A1ALW F 6 .   ? -19.58131 18.78385 -26.42679 1.000 27.72434 ? 405 A1ALW A O34 1 
HETATM 2386 O O   . HOH   G 7 .   ? 11.42630  27.67741 1.47328   1.000 43.39867 ? 501 HOH   A O   1 
HETATM 2387 O O   . HOH   G 7 .   ? 7.73879   24.92689 -26.73257 1.000 38.34325 ? 502 HOH   A O   1 
HETATM 2388 O O   . HOH   G 7 .   ? -17.15315 20.90069 -17.21399 1.000 34.63769 ? 503 HOH   A O   1 
HETATM 2389 O O   . HOH   G 7 .   ? 6.92007   12.82571 -16.88971 1.000 34.78448 ? 504 HOH   A O   1 
HETATM 2390 O O   . HOH   G 7 .   ? -28.41867 0.77240  -42.56645 1.000 49.94284 ? 505 HOH   A O   1 
HETATM 2391 O O   . HOH   G 7 .   ? 2.97570   26.14562 -15.27578 1.000 42.93169 ? 506 HOH   A O   1 
HETATM 2392 O O   . HOH   G 7 .   ? 20.79906  24.58946 -5.23512  1.000 39.23253 ? 507 HOH   A O   1 
HETATM 2393 O O   . HOH   G 7 .   ? 19.44611  37.29161 -9.38917  1.000 32.11827 ? 508 HOH   A O   1 
HETATM 2394 O O   . HOH   G 7 .   ? -27.63468 8.28693  -39.57669 1.000 54.17289 ? 509 HOH   A O   1 
HETATM 2395 O O   . HOH   G 7 .   ? 4.79107   25.28276 -22.62142 1.000 31.46784 ? 510 HOH   A O   1 
HETATM 2396 O O   . HOH   G 7 .   ? 21.74005  22.95658 -4.03187  1.000 27.44859 ? 511 HOH   A O   1 
HETATM 2397 O O   . HOH   G 7 .   ? -2.60819  6.02699  -32.04983 1.000 35.25373 ? 512 HOH   A O   1 
HETATM 2398 O O   . HOH   G 7 .   ? -8.15294  14.16689 -54.18761 1.000 35.71245 ? 513 HOH   A O   1 
HETATM 2399 O O   . HOH   G 7 .   ? -5.24800  17.96253 -13.13242 1.000 42.11426 ? 514 HOH   A O   1 
HETATM 2400 O O   . HOH   G 7 .   ? 12.04049  19.45167 -40.62296 1.000 44.39857 ? 515 HOH   A O   1 
HETATM 2401 O O   . HOH   G 7 .   ? 4.25076   21.37378 -5.43592  1.000 29.14001 ? 516 HOH   A O   1 
HETATM 2402 O O   . HOH   G 7 .   ? 8.75953   35.97813 -8.44094  1.000 33.67400 ? 517 HOH   A O   1 
HETATM 2403 O O   . HOH   G 7 .   ? 10.46277  36.54172 -3.60051  1.000 37.33327 ? 518 HOH   A O   1 
HETATM 2404 O O   . HOH   G 7 .   ? 19.22503  7.30623  -18.40673 1.000 33.31403 ? 519 HOH   A O   1 
HETATM 2405 O O   . HOH   G 7 .   ? -11.94980 28.78037 -27.05550 1.000 25.48505 ? 520 HOH   A O   1 
HETATM 2406 O O   . HOH   G 7 .   ? 0.45611   24.96413 -19.96465 1.000 28.09700 ? 521 HOH   A O   1 
HETATM 2407 O O   . HOH   G 7 .   ? -0.21208  26.16837 -43.70198 1.000 27.34419 ? 522 HOH   A O   1 
HETATM 2408 O O   . HOH   G 7 .   ? 1.78889   17.56106 -5.92917  1.000 30.34890 ? 523 HOH   A O   1 
HETATM 2409 O O   . HOH   G 7 .   ? -21.54856 19.03343 -24.76468 1.000 31.91337 ? 524 HOH   A O   1 
HETATM 2410 O O   . HOH   G 7 .   ? 15.37706  25.71391 -1.59085  1.000 29.71272 ? 525 HOH   A O   1 
HETATM 2411 O O   . HOH   G 7 .   ? 2.72618   24.90224 -20.89481 1.000 34.64202 ? 526 HOH   A O   1 
HETATM 2412 O O   . HOH   G 7 .   ? 9.33739   13.41655 -13.67737 1.000 20.72423 ? 527 HOH   A O   1 
HETATM 2413 O O   . HOH   G 7 .   ? -1.26790  12.26129 -33.64827 1.000 26.04012 ? 528 HOH   A O   1 
HETATM 2414 O O   . HOH   G 7 .   ? 1.68711   33.62160 -21.35827 1.000 22.06059 ? 529 HOH   A O   1 
HETATM 2415 O O   . HOH   G 7 .   ? -14.09007 3.65629  -35.27768 1.000 26.43344 ? 530 HOH   A O   1 
HETATM 2416 O O   . HOH   G 7 .   ? 28.28017  23.92066 -1.51351  1.000 36.27072 ? 531 HOH   A O   1 
HETATM 2417 O O   . HOH   G 7 .   ? -9.79152  16.49549 -13.13933 1.000 45.03615 ? 532 HOH   A O   1 
HETATM 2418 O O   . HOH   G 7 .   ? -20.01228 26.67118 -25.20784 1.000 28.71478 ? 533 HOH   A O   1 
HETATM 2419 O O   . HOH   G 7 .   ? -18.68932 19.91969 -49.28001 1.000 33.56459 ? 534 HOH   A O   1 
HETATM 2420 O O   . HOH   G 7 .   ? -2.74442  7.96521  -15.71678 1.000 37.35605 ? 535 HOH   A O   1 
HETATM 2421 O O   . HOH   G 7 .   ? -14.75426 6.31021  -27.67389 1.000 25.87919 ? 536 HOH   A O   1 
HETATM 2422 O O   . HOH   G 7 .   ? 18.024    36.680   -17.800   1.000 35.06042 ? 537 HOH   A O   1 
HETATM 2423 O O   . HOH   G 7 .   ? -17.44232 25.08061 -35.01687 1.000 22.92791 ? 538 HOH   A O   1 
HETATM 2424 O O   . HOH   G 7 .   ? -7.19628  16.51167 -14.51935 1.000 36.42889 ? 539 HOH   A O   1 
HETATM 2425 O O   . HOH   G 7 .   ? -19.85983 14.99734 -52.65216 1.000 35.81800 ? 540 HOH   A O   1 
HETATM 2426 O O   . HOH   G 7 .   ? 5.48897   22.52182 -26.46782 1.000 23.98740 ? 541 HOH   A O   1 
HETATM 2427 O O   . HOH   G 7 .   ? 13.24883  24.80480 -34.78025 1.000 38.99528 ? 542 HOH   A O   1 
HETATM 2428 O O   . HOH   G 7 .   ? -22.39312 16.32051 -25.24864 1.000 31.85362 ? 543 HOH   A O   1 
HETATM 2429 O O   . HOH   G 7 .   ? -5.34025  9.36824  -39.35963 1.000 32.03627 ? 544 HOH   A O   1 
HETATM 2430 O O   . HOH   G 7 .   ? -25.209   8.608    -21.449   1.000 37.77435 ? 545 HOH   A O   1 
HETATM 2431 O O   . HOH   G 7 .   ? 3.42467   28.69526 -37.87948 1.000 29.86974 ? 546 HOH   A O   1 
HETATM 2432 O O   . HOH   G 7 .   ? 7.84494   18.68263 -35.44189 1.000 33.04527 ? 547 HOH   A O   1 
HETATM 2433 O O   . HOH   G 7 .   ? 23.65859  23.28428 -22.74314 1.000 37.00295 ? 548 HOH   A O   1 
HETATM 2434 O O   . HOH   G 7 .   ? -5.54263  26.65182 -47.99669 1.000 37.21317 ? 549 HOH   A O   1 
HETATM 2435 O O   . HOH   G 7 .   ? 8.41363   16.36832 -19.35354 1.000 25.78733 ? 550 HOH   A O   1 
HETATM 2436 O O   . HOH   G 7 .   ? -20.18639 21.51761 -29.48015 1.000 33.40904 ? 551 HOH   A O   1 
HETATM 2437 O O   . HOH   G 7 .   ? -16.29214 2.63622  -32.55129 1.000 35.22621 ? 552 HOH   A O   1 
HETATM 2438 O O   . HOH   G 7 .   ? 17.91311  20.21608 -20.57109 1.000 26.35777 ? 553 HOH   A O   1 
HETATM 2439 O O   . HOH   G 7 .   ? 8.47123   21.23618 -28.60201 1.000 36.86684 ? 554 HOH   A O   1 
HETATM 2440 O O   . HOH   G 7 .   ? -7.54624  9.47981  -16.28732 1.000 36.20064 ? 555 HOH   A O   1 
HETATM 2441 O O   . HOH   G 7 .   ? -19.073   13.416   -58.018   1.000 37.12223 ? 556 HOH   A O   1 
HETATM 2442 O O   . HOH   G 7 .   ? -6.61067  23.90715 -34.53720 1.000 24.14039 ? 557 HOH   A O   1 
HETATM 2443 O O   . HOH   G 7 .   ? -2.89089  21.05989 -19.31947 1.000 29.56911 ? 558 HOH   A O   1 
HETATM 2444 O O   . HOH   G 7 .   ? 11.50026  8.23992  -17.38223 1.000 28.01793 ? 559 HOH   A O   1 
HETATM 2445 O O   . HOH   G 7 .   ? -3.38727  13.95354 -45.38421 1.000 29.62052 ? 560 HOH   A O   1 
HETATM 2446 O O   . HOH   G 7 .   ? -19.28280 23.65733 -43.30647 1.000 27.20971 ? 561 HOH   A O   1 
HETATM 2447 O O   . HOH   G 7 .   ? 26.13803  22.90894 -9.08903  1.000 25.75711 ? 562 HOH   A O   1 
HETATM 2448 O O   . HOH   G 7 .   ? 21.32287  10.57425 -10.76041 1.000 35.66555 ? 563 HOH   A O   1 
HETATM 2449 O O   . HOH   G 7 .   ? 7.31430   23.45443 -15.38576 1.000 17.41255 ? 564 HOH   A O   1 
HETATM 2450 O O   . HOH   G 7 .   ? -19.86139 3.21151  -31.94038 1.000 30.33288 ? 565 HOH   A O   1 
HETATM 2451 O O   . HOH   G 7 .   ? -7.51357  13.05772 -23.36707 1.000 23.85619 ? 566 HOH   A O   1 
HETATM 2452 O O   . HOH   G 7 .   ? -11.78892 2.28687  -36.74244 1.000 41.78532 ? 567 HOH   A O   1 
HETATM 2453 O O   . HOH   G 7 .   ? -15.88436 12.15100 -31.57180 1.000 22.77533 ? 568 HOH   A O   1 
HETATM 2454 O O   . HOH   G 7 .   ? -14.72619 6.71395  -19.64504 1.000 37.21214 ? 569 HOH   A O   1 
HETATM 2455 O O   . HOH   G 7 .   ? 7.85365   37.66815 -3.91977  1.000 40.80002 ? 570 HOH   A O   1 
HETATM 2456 O O   . HOH   G 7 .   ? 10.38963  16.39094 4.45802   1.000 53.28627 ? 571 HOH   A O   1 
HETATM 2457 O O   . HOH   G 7 .   ? 17.21785  17.35109 -23.26484 1.000 33.13397 ? 572 HOH   A O   1 
HETATM 2458 O O   . HOH   G 7 .   ? -10.04291 5.92004  -28.36506 1.000 24.36003 ? 573 HOH   A O   1 
HETATM 2459 O O   . HOH   G 7 .   ? -3.90806  6.59455  -23.07758 1.000 31.10431 ? 574 HOH   A O   1 
HETATM 2460 O O   . HOH   G 7 .   ? 0.74062   8.45271  -24.44674 1.000 33.93073 ? 575 HOH   A O   1 
HETATM 2461 O O   . HOH   G 7 .   ? -0.894    19.262   -50.851   1.000 41.28626 ? 576 HOH   A O   1 
HETATM 2462 O O   . HOH   G 7 .   ? 8.69158   28.21520 -24.00608 1.000 27.65941 ? 577 HOH   A O   1 
HETATM 2463 O O   . HOH   G 7 .   ? 16.11046  5.66617  -12.88565 1.000 30.83394 ? 578 HOH   A O   1 
HETATM 2464 O O   . HOH   G 7 .   ? -12.05632 5.65289  -26.65001 1.000 27.23012 ? 579 HOH   A O   1 
HETATM 2465 O O   . HOH   G 7 .   ? 8.18476   20.51160 -25.24712 1.000 32.69617 ? 580 HOH   A O   1 
HETATM 2466 O O   . HOH   G 7 .   ? 3.10989   10.85413 -39.47731 1.000 30.23374 ? 581 HOH   A O   1 
HETATM 2467 O O   . HOH   G 7 .   ? 3.53328   33.56991 -18.58557 1.000 27.74537 ? 582 HOH   A O   1 
HETATM 2468 O O   . HOH   G 7 .   ? 3.59867   17.15041 -31.11468 1.000 25.18341 ? 583 HOH   A O   1 
HETATM 2469 O O   . HOH   G 7 .   ? -0.16528  29.87390 -23.47883 1.000 32.65773 ? 584 HOH   A O   1 
HETATM 2470 O O   . HOH   G 7 .   ? 16.28803  35.75894 -5.90313  1.000 34.37169 ? 585 HOH   A O   1 
HETATM 2471 O O   . HOH   G 7 .   ? -23.15977 22.87551 -34.52986 1.000 39.40501 ? 586 HOH   A O   1 
HETATM 2472 O O   . HOH   G 7 .   ? 17.16482  37.19771 -1.78732  1.000 40.14711 ? 587 HOH   A O   1 
HETATM 2473 O O   . HOH   G 7 .   ? 22.40518  26.65958 1.66872   1.000 33.25157 ? 588 HOH   A O   1 
HETATM 2474 O O   . HOH   G 7 .   ? 6.54648   18.53976 -25.70937 1.000 26.20168 ? 589 HOH   A O   1 
HETATM 2475 O O   . HOH   G 7 .   ? 6.02343   27.94564 -23.02306 1.000 25.16648 ? 590 HOH   A O   1 
HETATM 2476 O O   . HOH   G 7 .   ? -24.47430 23.80611 -24.25432 1.000 35.66147 ? 591 HOH   A O   1 
HETATM 2477 O O   . HOH   G 7 .   ? -23.11875 11.58913 -52.16785 1.000 31.86808 ? 592 HOH   A O   1 
HETATM 2478 O O   . HOH   G 7 .   ? -5.70294  19.94896 -55.99642 1.000 32.99988 ? 593 HOH   A O   1 
HETATM 2479 O O   . HOH   G 7 .   ? 12.33074  32.76128 -27.38472 1.000 35.03316 ? 594 HOH   A O   1 
HETATM 2480 O O   . HOH   G 7 .   ? -5.17975  2.60630  -34.20071 1.000 39.65676 ? 595 HOH   A O   1 
HETATM 2481 O O   . HOH   G 7 .   ? 15.77576  5.92667  -16.42761 1.000 29.30724 ? 596 HOH   A O   1 
HETATM 2482 O O   . HOH   G 7 .   ? 3.72979   24.09847 -4.92650  1.000 33.76710 ? 597 HOH   A O   1 
HETATM 2483 O O   . HOH   G 7 .   ? 9.68337   36.72391 -16.03048 1.000 34.25439 ? 598 HOH   A O   1 
HETATM 2484 O O   . HOH   G 7 .   ? 8.04752   10.44168 -17.89379 1.000 40.48725 ? 599 HOH   A O   1 
HETATM 2485 O O   . HOH   G 7 .   ? -21.09526 17.76596 -13.68394 1.000 26.78618 ? 600 HOH   A O   1 
HETATM 2486 O O   . HOH   G 7 .   ? -15.43386 3.53574  -42.29363 1.000 34.47557 ? 601 HOH   A O   1 
HETATM 2487 O O   . HOH   G 7 .   ? -20.75782 8.02598  -50.50938 1.000 36.15459 ? 602 HOH   A O   1 
HETATM 2488 O O   . HOH   G 7 .   ? -17.50903 7.14963  -51.38352 1.000 48.63982 ? 603 HOH   A O   1 
HETATM 2489 O O   . HOH   G 7 .   ? 1.53212   23.91800 -13.12558 1.000 41.52504 ? 604 HOH   A O   1 
HETATM 2490 O O   . HOH   G 7 .   ? 11.76627  18.06668 -22.79172 1.000 24.86830 ? 605 HOH   A O   1 
HETATM 2491 O O   . HOH   G 7 .   ? 20.09764  6.91057  -6.38988  1.000 36.43308 ? 606 HOH   A O   1 
HETATM 2492 O O   . HOH   G 7 .   ? 6.59332   23.32603 -43.96590 1.000 37.99615 ? 607 HOH   A O   1 
HETATM 2493 O O   . HOH   G 7 .   ? -27.13439 -0.54885 -40.25405 1.000 44.26234 ? 608 HOH   A O   1 
HETATM 2494 O O   . HOH   G 7 .   ? 26.539    19.522   -16.861   1.000 36.55093 ? 609 HOH   A O   1 
HETATM 2495 O O   . HOH   G 7 .   ? 24.01360  16.33213 -11.39986 1.000 24.96678 ? 610 HOH   A O   1 
HETATM 2496 O O   . HOH   G 7 .   ? -18.39391 6.31472  -27.63284 1.000 29.47472 ? 611 HOH   A O   1 
HETATM 2497 O O   . HOH   G 7 .   ? 21.92122  9.69115  -8.18614  1.000 30.00868 ? 612 HOH   A O   1 
HETATM 2498 O O   . HOH   G 7 .   ? 16.70174  28.45815 -34.43540 1.000 44.16198 ? 613 HOH   A O   1 
HETATM 2499 O O   . HOH   G 7 .   ? -0.84821  6.60393  -24.32353 1.000 36.18238 ? 614 HOH   A O   1 
HETATM 2500 O O   . HOH   G 7 .   ? -11.04524 8.43690  -46.53656 1.000 37.40868 ? 615 HOH   A O   1 
HETATM 2501 O O   . HOH   G 7 .   ? 23.16472  11.59790 -12.45653 1.000 29.12947 ? 616 HOH   A O   1 
HETATM 2502 O O   . HOH   G 7 .   ? 17.03404  36.02253 0.04613   1.000 48.85851 ? 617 HOH   A O   1 
HETATM 2503 O O   . HOH   G 7 .   ? -7.53273  27.24262 -45.56995 1.000 48.50463 ? 618 HOH   A O   1 
HETATM 2504 O O   . HOH   G 7 .   ? -0.51614  9.13234  -34.05824 1.000 36.85935 ? 619 HOH   A O   1 
HETATM 2505 O O   . HOH   G 7 .   ? 8.79707   9.46001  -5.73335  1.000 39.03908 ? 620 HOH   A O   1 
HETATM 2506 O O   . HOH   G 7 .   ? -26.49533 22.03875 -33.51323 1.000 49.71901 ? 621 HOH   A O   1 
HETATM 2507 O O   . HOH   G 7 .   ? 0.696     31.436   -24.779   1.000 39.42773 ? 622 HOH   A O   1 
HETATM 2508 O O   . HOH   G 7 .   ? 5.93867   30.97306 -15.27084 1.000 35.37597 ? 623 HOH   A O   1 
HETATM 2509 O O   . HOH   G 7 .   ? 3.48074   25.80497 -44.52829 1.000 41.64188 ? 624 HOH   A O   1 
HETATM 2510 O O   . HOH   G 7 .   ? -10.37941 3.93797  -30.22163 1.000 37.80988 ? 625 HOH   A O   1 
HETATM 2511 O O   . HOH   G 7 .   ? 10.58696  16.12329 -21.29747 1.000 33.22500 ? 626 HOH   A O   1 
HETATM 2512 O O   . HOH   G 7 .   ? -26.64559 14.04638 -38.90241 1.000 36.84435 ? 627 HOH   A O   1 
HETATM 2513 O O   . HOH   G 7 .   ? 8.78377   8.32288  -16.09023 1.000 35.94437 ? 628 HOH   A O   1 
HETATM 2514 O O   . HOH   G 7 .   ? 13.18070  23.38947 -33.18038 1.000 48.54016 ? 629 HOH   A O   1 
HETATM 2515 O O   . HOH   G 7 .   ? -17.058   17.223   -10.363   1.000 41.65551 ? 630 HOH   A O   1 
HETATM 2516 O O   . HOH   G 7 .   ? 18.22909  36.63243 -4.11474  1.000 40.93562 ? 631 HOH   A O   1 
HETATM 2517 O O   . HOH   G 7 .   ? 6.26657   16.42735 -31.09025 1.000 34.85502 ? 632 HOH   A O   1 
HETATM 2518 O O   . HOH   G 7 .   ? 16.86561  20.28125 -23.28044 1.000 38.66576 ? 633 HOH   A O   1 
HETATM 2519 O O   . HOH   G 7 .   ? -3.12943  8.54030  -40.49045 1.000 36.43582 ? 634 HOH   A O   1 
HETATM 2520 O O   . HOH   G 7 .   ? 8.25839   13.93482 -18.58497 1.000 31.53494 ? 635 HOH   A O   1 
HETATM 2521 O O   . HOH   G 7 .   ? 14.17528  27.29245 0.11116   1.000 36.28748 ? 636 HOH   A O   1 
HETATM 2522 O O   . HOH   G 7 .   ? 5.39870   24.41915 -2.33269  1.000 41.18752 ? 637 HOH   A O   1 
HETATM 2523 O O   . HOH   G 7 .   ? -24.621   5.180    -18.000   1.000 44.34139 ? 638 HOH   A O   1 
HETATM 2524 O O   . HOH   G 7 .   ? 0.51707   32.80974 -18.98671 1.000 36.00377 ? 639 HOH   A O   1 
HETATM 2525 O O   . HOH   G 7 .   ? 3.78400   20.24303 -2.83835  1.000 37.20896 ? 640 HOH   A O   1 
HETATM 2526 O O   . HOH   G 7 .   ? -12.68064 2.99883  -25.84073 1.000 39.53368 ? 641 HOH   A O   1 
HETATM 2527 O O   . HOH   G 7 .   ? -21.319   13.635   -12.234   1.000 34.98190 ? 642 HOH   A O   1 
HETATM 2528 O O   . HOH   G 7 .   ? 20.11051  4.51809  -15.44640 1.000 42.75475 ? 643 HOH   A O   1 
# 
