data_9B9W
# 
_entry.id   9B9W 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9B9W         pdb_00009b9w 10.2210/pdb9b9w/pdb 
WWPDB D_1000282943 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2024-11-06 
2 'Structure model' 1 1 2024-12-04 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_CSD'          
4  2 'Structure model' '_citation.journal_id_ISSN'         
5  2 'Structure model' '_citation.journal_volume'          
6  2 'Structure model' '_citation.page_first'              
7  2 'Structure model' '_citation.page_last'               
8  2 'Structure model' '_citation.pdbx_database_id_DOI'    
9  2 'Structure model' '_citation.pdbx_database_id_PubMed' 
10 2 'Structure model' '_citation.title'                   
11 2 'Structure model' '_citation.year'                    
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9B9W 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-03 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              mvedadi@oicr.on.ca 
_pdbx_contact_author.name_first         Masoud 
_pdbx_contact_author.name_last          Vedadi 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0574-0169 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Mabanglo, M.F.' 1 0000-0003-4671-4159 
'Wilson, B.J.'   2 0009-0003-1132-8095 
'Mamai, A.'      3 0009-0001-3125-1991 
'Hoffer, L.'     4 0000-0003-1906-7128 
'Al-awar, R.'    5 0000-0002-4185-055X 
'Vedadi, M.'     6 0000-0002-0574-0169 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            15 
_citation.language                  ? 
_citation.page_first                10165 
_citation.page_last                 10165 
_citation.title                     
'Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-024-54500-x 
_citation.pdbx_database_id_PubMed   39580491 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Mabanglo, M.F.'       1  ?                   
primary 'Wilson, B.'           2  ?                   
primary 'Noureldin, M.'        3  ?                   
primary 'Kimani, S.W.'         4  0000-0002-6960-3833 
primary 'Mamai, A.'            5  ?                   
primary 'Krausser, C.'         6  ?                   
primary 'Gonzalez-Alvarez, H.' 7  ?                   
primary 'Srivastava, S.'       8  ?                   
primary 'Mohammed, M.'         9  ?                   
primary 'Hoffer, L.'           10 0000-0003-1906-7128 
primary 'Chan, M.'             11 ?                   
primary 'Avrumutsoae, J.'      12 ?                   
primary 'Li, A.S.M.'           13 ?                   
primary 'Hajian, T.'           14 ?                   
primary 'Tucker, S.'           15 ?                   
primary 'Green, S.'            16 0000-0002-2960-9683 
primary 'Szewczyk, M.'         17 ?                   
primary 'Barsyte-Lovejoy, D.'  18 0000-0002-6560-9621 
primary 'Santhakumar, V.'      19 0000-0002-7001-557X 
primary 'Ackloo, S.'           20 0000-0002-9696-1839 
primary 'Loppnau, P.'          21 ?                   
primary 'Li, Y.'               22 0000-0002-9512-5265 
primary 'Seitova, A.'          23 ?                   
primary 'Kiyota, T.'           24 0000-0001-6313-3482 
primary 'Wang, J.G.'           25 ?                   
primary 'Prive, G.G.'          26 ?                   
primary 'Kuntz, D.A.'          27 0000-0003-3584-4804 
primary 'Patel, B.'            28 ?                   
primary 'Rathod, V.'           29 ?                   
primary 'Vala, A.'             30 ?                   
primary 'Rout, B.'             31 ?                   
primary 'Aman, A.'             32 0000-0002-0275-205X 
primary 'Poda, G.'             33 ?                   
primary 'Uehling, D.'          34 ?                   
primary 'Ramnauth, J.'         35 ?                   
primary 'Halabelian, L.'       36 0000-0003-4361-3619 
primary 'Marcellus, R.'        37 ?                   
primary 'Al-Awar, R.'          38 ?                   
primary 'Vedadi, M.'           39 0000-0002-0574-0169 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'WD repeat-containing protein 5' 36433.207 1   ?        ? ?                    ? 
2 polymer     man 'DDB1- and CUL4-associated factor 1' 38298.820 1   2.7.11.1 ? 'residues 1080-1390' ? 
3 non-polymer syn 
;(4P)-N-[(1R)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-4-(4-chloro-2-fluorophenyl)-5-[(25E)-1-{(1P)-6-fluoro-3'-[4-fluoro-2-(trifluoromethyl)benzamido]-4'-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl][1,1'-biphenyl]-3-yl}-1,24-dioxo-5,8,11,14,17,20-hexaoxa-2,23-diazahexacos-25-en-26-yl]-1H-pyrrole-3-carboxamide
;
1344.201  1   ?        ? ?                    ? 
4 water       nat water 18.015    475 ?        ? ?                    ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 'BMP2-induced 3-kb gene protein'                                                                
2 'HIV-1 Vpr-binding protein,VprBP,Serine/threonine-protein kinase VPRBP,Vpr-interacting protein' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;MHHHHHHSSGRENLYFQGTQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG
HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK
TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK
GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDK
TIKLWKSDC
;
;MHHHHHHSSGRENLYFQGTQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG
HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK
TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK
GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDK
TIKLWKSDC
;
A ? 
2 'polypeptide(L)' no no 
;MGSSHHHHHHSSGRENLYFQGSSRASAFRPISVFREANEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYN
CHNSAITHLEPSRDGSLLLTSATWSQPLSALWGMKSVFDMKHSFTEDHYVEFSKHSQDRVIGTKGDIAHIYDIQTGNKLL
TLFNPDLANNYKRNCATFNPTDDLVLNDGVLWDVRSAQAIHKFDKFNMNISGVFHPNGLEVIINTEIWDLRTFHLLHTVP
ALDQCRVVFNHTGTVMYGAMLQADDEDDLMEERMKSPFGSSFRTFNATDYKPIATIDVKRNIFDLCTDTKDCYLAVIENQ
GSMDALNMDTVCRLYEVG
;
;MGSSHHHHHHSSGRENLYFQGSSRASAFRPISVFREANEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYN
CHNSAITHLEPSRDGSLLLTSATWSQPLSALWGMKSVFDMKHSFTEDHYVEFSKHSQDRVIGTKGDIAHIYDIQTGNKLL
TLFNPDLANNYKRNCATFNPTDDLVLNDGVLWDVRSAQAIHKFDKFNMNISGVFHPNGLEVIINTEIWDLRTFHLLHTVP
ALDQCRVVFNHTGTVMYGAMLQADDEDDLMEERMKSPFGSSFRTFNATDYKPIATIDVKRNIFDLCTDTKDCYLAVIENQ
GSMDALNMDTVCRLYEVG
;
B ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 
;(4P)-N-[(1R)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-4-(4-chloro-2-fluorophenyl)-5-[(25E)-1-{(1P)-6-fluoro-3'-[4-fluoro-2-(trifluoromethyl)benzamido]-4'-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl][1,1'-biphenyl]-3-yl}-1,24-dioxo-5,8,11,14,17,20-hexaoxa-2,23-diazahexacos-25-en-26-yl]-1H-pyrrole-3-carboxamide
;
A1ANN 
4 water HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   HIS n 
1 3   HIS n 
1 4   HIS n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   SER n 
1 9   SER n 
1 10  GLY n 
1 11  ARG n 
1 12  GLU n 
1 13  ASN n 
1 14  LEU n 
1 15  TYR n 
1 16  PHE n 
1 17  GLN n 
1 18  GLY n 
1 19  THR n 
1 20  GLN n 
1 21  SER n 
1 22  LYS n 
1 23  PRO n 
1 24  THR n 
1 25  PRO n 
1 26  VAL n 
1 27  LYS n 
1 28  PRO n 
1 29  ASN n 
1 30  TYR n 
1 31  ALA n 
1 32  LEU n 
1 33  LYS n 
1 34  PHE n 
1 35  THR n 
1 36  LEU n 
1 37  ALA n 
1 38  GLY n 
1 39  HIS n 
1 40  THR n 
1 41  LYS n 
1 42  ALA n 
1 43  VAL n 
1 44  SER n 
1 45  SER n 
1 46  VAL n 
1 47  LYS n 
1 48  PHE n 
1 49  SER n 
1 50  PRO n 
1 51  ASN n 
1 52  GLY n 
1 53  GLU n 
1 54  TRP n 
1 55  LEU n 
1 56  ALA n 
1 57  SER n 
1 58  SER n 
1 59  SER n 
1 60  ALA n 
1 61  ASP n 
1 62  LYS n 
1 63  LEU n 
1 64  ILE n 
1 65  LYS n 
1 66  ILE n 
1 67  TRP n 
1 68  GLY n 
1 69  ALA n 
1 70  TYR n 
1 71  ASP n 
1 72  GLY n 
1 73  LYS n 
1 74  PHE n 
1 75  GLU n 
1 76  LYS n 
1 77  THR n 
1 78  ILE n 
1 79  SER n 
1 80  GLY n 
1 81  HIS n 
1 82  LYS n 
1 83  LEU n 
1 84  GLY n 
1 85  ILE n 
1 86  SER n 
1 87  ASP n 
1 88  VAL n 
1 89  ALA n 
1 90  TRP n 
1 91  SER n 
1 92  SER n 
1 93  ASP n 
1 94  SER n 
1 95  ASN n 
1 96  LEU n 
1 97  LEU n 
1 98  VAL n 
1 99  SER n 
1 100 ALA n 
1 101 SER n 
1 102 ASP n 
1 103 ASP n 
1 104 LYS n 
1 105 THR n 
1 106 LEU n 
1 107 LYS n 
1 108 ILE n 
1 109 TRP n 
1 110 ASP n 
1 111 VAL n 
1 112 SER n 
1 113 SER n 
1 114 GLY n 
1 115 LYS n 
1 116 CYS n 
1 117 LEU n 
1 118 LYS n 
1 119 THR n 
1 120 LEU n 
1 121 LYS n 
1 122 GLY n 
1 123 HIS n 
1 124 SER n 
1 125 ASN n 
1 126 TYR n 
1 127 VAL n 
1 128 PHE n 
1 129 CYS n 
1 130 CYS n 
1 131 ASN n 
1 132 PHE n 
1 133 ASN n 
1 134 PRO n 
1 135 GLN n 
1 136 SER n 
1 137 ASN n 
1 138 LEU n 
1 139 ILE n 
1 140 VAL n 
1 141 SER n 
1 142 GLY n 
1 143 SER n 
1 144 PHE n 
1 145 ASP n 
1 146 GLU n 
1 147 SER n 
1 148 VAL n 
1 149 ARG n 
1 150 ILE n 
1 151 TRP n 
1 152 ASP n 
1 153 VAL n 
1 154 LYS n 
1 155 THR n 
1 156 GLY n 
1 157 LYS n 
1 158 CYS n 
1 159 LEU n 
1 160 LYS n 
1 161 THR n 
1 162 LEU n 
1 163 PRO n 
1 164 ALA n 
1 165 HIS n 
1 166 SER n 
1 167 ASP n 
1 168 PRO n 
1 169 VAL n 
1 170 SER n 
1 171 ALA n 
1 172 VAL n 
1 173 HIS n 
1 174 PHE n 
1 175 ASN n 
1 176 ARG n 
1 177 ASP n 
1 178 GLY n 
1 179 SER n 
1 180 LEU n 
1 181 ILE n 
1 182 VAL n 
1 183 SER n 
1 184 SER n 
1 185 SER n 
1 186 TYR n 
1 187 ASP n 
1 188 GLY n 
1 189 LEU n 
1 190 CYS n 
1 191 ARG n 
1 192 ILE n 
1 193 TRP n 
1 194 ASP n 
1 195 THR n 
1 196 ALA n 
1 197 SER n 
1 198 GLY n 
1 199 GLN n 
1 200 CYS n 
1 201 LEU n 
1 202 LYS n 
1 203 THR n 
1 204 LEU n 
1 205 ILE n 
1 206 ASP n 
1 207 ASP n 
1 208 ASP n 
1 209 ASN n 
1 210 PRO n 
1 211 PRO n 
1 212 VAL n 
1 213 SER n 
1 214 PHE n 
1 215 VAL n 
1 216 LYS n 
1 217 PHE n 
1 218 SER n 
1 219 PRO n 
1 220 ASN n 
1 221 GLY n 
1 222 LYS n 
1 223 TYR n 
1 224 ILE n 
1 225 LEU n 
1 226 ALA n 
1 227 ALA n 
1 228 THR n 
1 229 LEU n 
1 230 ASP n 
1 231 ASN n 
1 232 THR n 
1 233 LEU n 
1 234 LYS n 
1 235 LEU n 
1 236 TRP n 
1 237 ASP n 
1 238 TYR n 
1 239 SER n 
1 240 LYS n 
1 241 GLY n 
1 242 LYS n 
1 243 CYS n 
1 244 LEU n 
1 245 LYS n 
1 246 THR n 
1 247 TYR n 
1 248 THR n 
1 249 GLY n 
1 250 HIS n 
1 251 LYS n 
1 252 ASN n 
1 253 GLU n 
1 254 LYS n 
1 255 TYR n 
1 256 CYS n 
1 257 ILE n 
1 258 PHE n 
1 259 ALA n 
1 260 ASN n 
1 261 PHE n 
1 262 SER n 
1 263 VAL n 
1 264 THR n 
1 265 GLY n 
1 266 GLY n 
1 267 LYS n 
1 268 TRP n 
1 269 ILE n 
1 270 VAL n 
1 271 SER n 
1 272 GLY n 
1 273 SER n 
1 274 GLU n 
1 275 ASP n 
1 276 ASN n 
1 277 LEU n 
1 278 VAL n 
1 279 TYR n 
1 280 ILE n 
1 281 TRP n 
1 282 ASN n 
1 283 LEU n 
1 284 GLN n 
1 285 THR n 
1 286 LYS n 
1 287 GLU n 
1 288 ILE n 
1 289 VAL n 
1 290 GLN n 
1 291 LYS n 
1 292 LEU n 
1 293 GLN n 
1 294 GLY n 
1 295 HIS n 
1 296 THR n 
1 297 ASP n 
1 298 VAL n 
1 299 VAL n 
1 300 ILE n 
1 301 SER n 
1 302 THR n 
1 303 ALA n 
1 304 CYS n 
1 305 HIS n 
1 306 PRO n 
1 307 THR n 
1 308 GLU n 
1 309 ASN n 
1 310 ILE n 
1 311 ILE n 
1 312 ALA n 
1 313 SER n 
1 314 ALA n 
1 315 ALA n 
1 316 LEU n 
1 317 GLU n 
1 318 ASN n 
1 319 ASP n 
1 320 LYS n 
1 321 THR n 
1 322 ILE n 
1 323 LYS n 
1 324 LEU n 
1 325 TRP n 
1 326 LYS n 
1 327 SER n 
1 328 ASP n 
1 329 CYS n 
2 1   MET n 
2 2   GLY n 
2 3   SER n 
2 4   SER n 
2 5   HIS n 
2 6   HIS n 
2 7   HIS n 
2 8   HIS n 
2 9   HIS n 
2 10  HIS n 
2 11  SER n 
2 12  SER n 
2 13  GLY n 
2 14  ARG n 
2 15  GLU n 
2 16  ASN n 
2 17  LEU n 
2 18  TYR n 
2 19  PHE n 
2 20  GLN n 
2 21  GLY n 
2 22  SER n 
2 23  SER n 
2 24  ARG n 
2 25  ALA n 
2 26  SER n 
2 27  ALA n 
2 28  PHE n 
2 29  ARG n 
2 30  PRO n 
2 31  ILE n 
2 32  SER n 
2 33  VAL n 
2 34  PHE n 
2 35  ARG n 
2 36  GLU n 
2 37  ALA n 
2 38  ASN n 
2 39  GLU n 
2 40  ASP n 
2 41  GLU n 
2 42  SER n 
2 43  GLY n 
2 44  PHE n 
2 45  THR n 
2 46  CYS n 
2 47  CYS n 
2 48  ALA n 
2 49  PHE n 
2 50  SER n 
2 51  ALA n 
2 52  ARG n 
2 53  GLU n 
2 54  ARG n 
2 55  PHE n 
2 56  LEU n 
2 57  MET n 
2 58  LEU n 
2 59  GLY n 
2 60  THR n 
2 61  CYS n 
2 62  THR n 
2 63  GLY n 
2 64  GLN n 
2 65  LEU n 
2 66  LYS n 
2 67  LEU n 
2 68  TYR n 
2 69  ASN n 
2 70  VAL n 
2 71  PHE n 
2 72  SER n 
2 73  GLY n 
2 74  GLN n 
2 75  GLU n 
2 76  GLU n 
2 77  ALA n 
2 78  SER n 
2 79  TYR n 
2 80  ASN n 
2 81  CYS n 
2 82  HIS n 
2 83  ASN n 
2 84  SER n 
2 85  ALA n 
2 86  ILE n 
2 87  THR n 
2 88  HIS n 
2 89  LEU n 
2 90  GLU n 
2 91  PRO n 
2 92  SER n 
2 93  ARG n 
2 94  ASP n 
2 95  GLY n 
2 96  SER n 
2 97  LEU n 
2 98  LEU n 
2 99  LEU n 
2 100 THR n 
2 101 SER n 
2 102 ALA n 
2 103 THR n 
2 104 TRP n 
2 105 SER n 
2 106 GLN n 
2 107 PRO n 
2 108 LEU n 
2 109 SER n 
2 110 ALA n 
2 111 LEU n 
2 112 TRP n 
2 113 GLY n 
2 114 MET n 
2 115 LYS n 
2 116 SER n 
2 117 VAL n 
2 118 PHE n 
2 119 ASP n 
2 120 MET n 
2 121 LYS n 
2 122 HIS n 
2 123 SER n 
2 124 PHE n 
2 125 THR n 
2 126 GLU n 
2 127 ASP n 
2 128 HIS n 
2 129 TYR n 
2 130 VAL n 
2 131 GLU n 
2 132 PHE n 
2 133 SER n 
2 134 LYS n 
2 135 HIS n 
2 136 SER n 
2 137 GLN n 
2 138 ASP n 
2 139 ARG n 
2 140 VAL n 
2 141 ILE n 
2 142 GLY n 
2 143 THR n 
2 144 LYS n 
2 145 GLY n 
2 146 ASP n 
2 147 ILE n 
2 148 ALA n 
2 149 HIS n 
2 150 ILE n 
2 151 TYR n 
2 152 ASP n 
2 153 ILE n 
2 154 GLN n 
2 155 THR n 
2 156 GLY n 
2 157 ASN n 
2 158 LYS n 
2 159 LEU n 
2 160 LEU n 
2 161 THR n 
2 162 LEU n 
2 163 PHE n 
2 164 ASN n 
2 165 PRO n 
2 166 ASP n 
2 167 LEU n 
2 168 ALA n 
2 169 ASN n 
2 170 ASN n 
2 171 TYR n 
2 172 LYS n 
2 173 ARG n 
2 174 ASN n 
2 175 CYS n 
2 176 ALA n 
2 177 THR n 
2 178 PHE n 
2 179 ASN n 
2 180 PRO n 
2 181 THR n 
2 182 ASP n 
2 183 ASP n 
2 184 LEU n 
2 185 VAL n 
2 186 LEU n 
2 187 ASN n 
2 188 ASP n 
2 189 GLY n 
2 190 VAL n 
2 191 LEU n 
2 192 TRP n 
2 193 ASP n 
2 194 VAL n 
2 195 ARG n 
2 196 SER n 
2 197 ALA n 
2 198 GLN n 
2 199 ALA n 
2 200 ILE n 
2 201 HIS n 
2 202 LYS n 
2 203 PHE n 
2 204 ASP n 
2 205 LYS n 
2 206 PHE n 
2 207 ASN n 
2 208 MET n 
2 209 ASN n 
2 210 ILE n 
2 211 SER n 
2 212 GLY n 
2 213 VAL n 
2 214 PHE n 
2 215 HIS n 
2 216 PRO n 
2 217 ASN n 
2 218 GLY n 
2 219 LEU n 
2 220 GLU n 
2 221 VAL n 
2 222 ILE n 
2 223 ILE n 
2 224 ASN n 
2 225 THR n 
2 226 GLU n 
2 227 ILE n 
2 228 TRP n 
2 229 ASP n 
2 230 LEU n 
2 231 ARG n 
2 232 THR n 
2 233 PHE n 
2 234 HIS n 
2 235 LEU n 
2 236 LEU n 
2 237 HIS n 
2 238 THR n 
2 239 VAL n 
2 240 PRO n 
2 241 ALA n 
2 242 LEU n 
2 243 ASP n 
2 244 GLN n 
2 245 CYS n 
2 246 ARG n 
2 247 VAL n 
2 248 VAL n 
2 249 PHE n 
2 250 ASN n 
2 251 HIS n 
2 252 THR n 
2 253 GLY n 
2 254 THR n 
2 255 VAL n 
2 256 MET n 
2 257 TYR n 
2 258 GLY n 
2 259 ALA n 
2 260 MET n 
2 261 LEU n 
2 262 GLN n 
2 263 ALA n 
2 264 ASP n 
2 265 ASP n 
2 266 GLU n 
2 267 ASP n 
2 268 ASP n 
2 269 LEU n 
2 270 MET n 
2 271 GLU n 
2 272 GLU n 
2 273 ARG n 
2 274 MET n 
2 275 LYS n 
2 276 SER n 
2 277 PRO n 
2 278 PHE n 
2 279 GLY n 
2 280 SER n 
2 281 SER n 
2 282 PHE n 
2 283 ARG n 
2 284 THR n 
2 285 PHE n 
2 286 ASN n 
2 287 ALA n 
2 288 THR n 
2 289 ASP n 
2 290 TYR n 
2 291 LYS n 
2 292 PRO n 
2 293 ILE n 
2 294 ALA n 
2 295 THR n 
2 296 ILE n 
2 297 ASP n 
2 298 VAL n 
2 299 LYS n 
2 300 ARG n 
2 301 ASN n 
2 302 ILE n 
2 303 PHE n 
2 304 ASP n 
2 305 LEU n 
2 306 CYS n 
2 307 THR n 
2 308 ASP n 
2 309 THR n 
2 310 LYS n 
2 311 ASP n 
2 312 CYS n 
2 313 TYR n 
2 314 LEU n 
2 315 ALA n 
2 316 VAL n 
2 317 ILE n 
2 318 GLU n 
2 319 ASN n 
2 320 GLN n 
2 321 GLY n 
2 322 SER n 
2 323 MET n 
2 324 ASP n 
2 325 ALA n 
2 326 LEU n 
2 327 ASN n 
2 328 MET n 
2 329 ASP n 
2 330 THR n 
2 331 VAL n 
2 332 CYS n 
2 333 ARG n 
2 334 LEU n 
2 335 TYR n 
2 336 GLU n 
2 337 VAL n 
2 338 GLY n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 329 human ? 'WDR5, BIG3'                  ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
;Escherichia coli 'BL21-Gold(DE3)pLysS AG'
;
866768 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 338 human ? 'DCAF1, KIAA0800, RIP, VPRBP' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Spodoptera frugiperda'                     7108   ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1ANN non-polymer         . 
;(4P)-N-[(1R)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-4-(4-chloro-2-fluorophenyl)-5-[(25E)-1-{(1P)-6-fluoro-3'-[4-fluoro-2-(trifluoromethyl)benzamido]-4'-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl][1,1'-biphenyl]-3-yl}-1,24-dioxo-5,8,11,14,17,20-hexaoxa-2,23-diazahexacos-25-en-26-yl]-1H-pyrrole-3-carboxamide
;
OICR-40792 'C65 H71 Cl2 F7 N8 O11' 1344.201 
ALA   'L-peptide linking' y ALANINE ?          'C3 H7 N O2'            89.093   
ARG   'L-peptide linking' y ARGININE ?          'C6 H15 N4 O2 1'        175.209  
ASN   'L-peptide linking' y ASPARAGINE ?          'C4 H8 N2 O3'           132.118  
ASP   'L-peptide linking' y 'ASPARTIC ACID' ?          'C4 H7 N O4'            133.103  
CYS   'L-peptide linking' y CYSTEINE ?          'C3 H7 N O2 S'          121.158  
GLN   'L-peptide linking' y GLUTAMINE ?          'C5 H10 N2 O3'          146.144  
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ?          'C5 H9 N O4'            147.129  
GLY   'peptide linking'   y GLYCINE ?          'C2 H5 N O2'            75.067   
HIS   'L-peptide linking' y HISTIDINE ?          'C6 H10 N3 O2 1'        156.162  
HOH   non-polymer         . WATER ?          'H2 O'                  18.015   
ILE   'L-peptide linking' y ISOLEUCINE ?          'C6 H13 N O2'           131.173  
LEU   'L-peptide linking' y LEUCINE ?          'C6 H13 N O2'           131.173  
LYS   'L-peptide linking' y LYSINE ?          'C6 H15 N2 O2 1'        147.195  
MET   'L-peptide linking' y METHIONINE ?          'C5 H11 N O2 S'         149.211  
PHE   'L-peptide linking' y PHENYLALANINE ?          'C9 H11 N O2'           165.189  
PRO   'L-peptide linking' y PROLINE ?          'C5 H9 N O2'            115.130  
SER   'L-peptide linking' y SERINE ?          'C3 H7 N O3'            105.093  
THR   'L-peptide linking' y THREONINE ?          'C4 H9 N O3'            119.119  
TRP   'L-peptide linking' y TRYPTOPHAN ?          'C11 H12 N2 O2'         204.225  
TYR   'L-peptide linking' y TYROSINE ?          'C9 H11 N O3'           181.189  
VAL   'L-peptide linking' y VALINE ?          'C5 H11 N O2'           117.146  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   6    ?    ?   ?   A . n 
A 1 2   HIS 2   7    ?    ?   ?   A . n 
A 1 3   HIS 3   8    ?    ?   ?   A . n 
A 1 4   HIS 4   9    ?    ?   ?   A . n 
A 1 5   HIS 5   10   ?    ?   ?   A . n 
A 1 6   HIS 6   11   ?    ?   ?   A . n 
A 1 7   HIS 7   12   ?    ?   ?   A . n 
A 1 8   SER 8   13   ?    ?   ?   A . n 
A 1 9   SER 9   14   ?    ?   ?   A . n 
A 1 10  GLY 10  15   ?    ?   ?   A . n 
A 1 11  ARG 11  16   ?    ?   ?   A . n 
A 1 12  GLU 12  17   ?    ?   ?   A . n 
A 1 13  ASN 13  18   ?    ?   ?   A . n 
A 1 14  LEU 14  19   ?    ?   ?   A . n 
A 1 15  TYR 15  20   ?    ?   ?   A . n 
A 1 16  PHE 16  21   ?    ?   ?   A . n 
A 1 17  GLN 17  22   ?    ?   ?   A . n 
A 1 18  GLY 18  23   ?    ?   ?   A . n 
A 1 19  THR 19  24   ?    ?   ?   A . n 
A 1 20  GLN 20  25   ?    ?   ?   A . n 
A 1 21  SER 21  26   ?    ?   ?   A . n 
A 1 22  LYS 22  27   ?    ?   ?   A . n 
A 1 23  PRO 23  28   ?    ?   ?   A . n 
A 1 24  THR 24  29   ?    ?   ?   A . n 
A 1 25  PRO 25  30   ?    ?   ?   A . n 
A 1 26  VAL 26  31   31   VAL VAL A . n 
A 1 27  LYS 27  32   32   LYS LYS A . n 
A 1 28  PRO 28  33   33   PRO PRO A . n 
A 1 29  ASN 29  34   34   ASN ASN A . n 
A 1 30  TYR 30  35   35   TYR TYR A . n 
A 1 31  ALA 31  36   36   ALA ALA A . n 
A 1 32  LEU 32  37   37   LEU LEU A . n 
A 1 33  LYS 33  38   38   LYS LYS A . n 
A 1 34  PHE 34  39   39   PHE PHE A . n 
A 1 35  THR 35  40   40   THR THR A . n 
A 1 36  LEU 36  41   41   LEU LEU A . n 
A 1 37  ALA 37  42   42   ALA ALA A . n 
A 1 38  GLY 38  43   43   GLY GLY A . n 
A 1 39  HIS 39  44   44   HIS HIS A . n 
A 1 40  THR 40  45   45   THR THR A . n 
A 1 41  LYS 41  46   46   LYS LYS A . n 
A 1 42  ALA 42  47   47   ALA ALA A . n 
A 1 43  VAL 43  48   48   VAL VAL A . n 
A 1 44  SER 44  49   49   SER SER A . n 
A 1 45  SER 45  50   50   SER SER A . n 
A 1 46  VAL 46  51   51   VAL VAL A . n 
A 1 47  LYS 47  52   52   LYS LYS A . n 
A 1 48  PHE 48  53   53   PHE PHE A . n 
A 1 49  SER 49  54   54   SER SER A . n 
A 1 50  PRO 50  55   55   PRO PRO A . n 
A 1 51  ASN 51  56   56   ASN ASN A . n 
A 1 52  GLY 52  57   57   GLY GLY A . n 
A 1 53  GLU 53  58   58   GLU GLU A . n 
A 1 54  TRP 54  59   59   TRP TRP A . n 
A 1 55  LEU 55  60   60   LEU LEU A . n 
A 1 56  ALA 56  61   61   ALA ALA A . n 
A 1 57  SER 57  62   62   SER SER A . n 
A 1 58  SER 58  63   63   SER SER A . n 
A 1 59  SER 59  64   64   SER SER A . n 
A 1 60  ALA 60  65   65   ALA ALA A . n 
A 1 61  ASP 61  66   66   ASP ASP A . n 
A 1 62  LYS 62  67   67   LYS LYS A . n 
A 1 63  LEU 63  68   68   LEU LEU A . n 
A 1 64  ILE 64  69   69   ILE ILE A . n 
A 1 65  LYS 65  70   70   LYS LYS A . n 
A 1 66  ILE 66  71   71   ILE ILE A . n 
A 1 67  TRP 67  72   72   TRP TRP A . n 
A 1 68  GLY 68  73   73   GLY GLY A . n 
A 1 69  ALA 69  74   74   ALA ALA A . n 
A 1 70  TYR 70  75   75   TYR TYR A . n 
A 1 71  ASP 71  76   76   ASP ASP A . n 
A 1 72  GLY 72  77   77   GLY GLY A . n 
A 1 73  LYS 73  78   78   LYS LYS A . n 
A 1 74  PHE 74  79   79   PHE PHE A . n 
A 1 75  GLU 75  80   80   GLU GLU A . n 
A 1 76  LYS 76  81   81   LYS LYS A . n 
A 1 77  THR 77  82   82   THR THR A . n 
A 1 78  ILE 78  83   83   ILE ILE A . n 
A 1 79  SER 79  84   84   SER SER A . n 
A 1 80  GLY 80  85   85   GLY GLY A . n 
A 1 81  HIS 81  86   86   HIS HIS A . n 
A 1 82  LYS 82  87   87   LYS LYS A . n 
A 1 83  LEU 83  88   88   LEU LEU A . n 
A 1 84  GLY 84  89   89   GLY GLY A . n 
A 1 85  ILE 85  90   90   ILE ILE A . n 
A 1 86  SER 86  91   91   SER SER A . n 
A 1 87  ASP 87  92   92   ASP ASP A . n 
A 1 88  VAL 88  93   93   VAL VAL A . n 
A 1 89  ALA 89  94   94   ALA ALA A . n 
A 1 90  TRP 90  95   95   TRP TRP A . n 
A 1 91  SER 91  96   96   SER SER A . n 
A 1 92  SER 92  97   97   SER SER A . n 
A 1 93  ASP 93  98   98   ASP ASP A . n 
A 1 94  SER 94  99   99   SER SER A . n 
A 1 95  ASN 95  100  100  ASN ASN A . n 
A 1 96  LEU 96  101  101  LEU LEU A . n 
A 1 97  LEU 97  102  102  LEU LEU A . n 
A 1 98  VAL 98  103  103  VAL VAL A . n 
A 1 99  SER 99  104  104  SER SER A . n 
A 1 100 ALA 100 105  105  ALA ALA A . n 
A 1 101 SER 101 106  106  SER SER A . n 
A 1 102 ASP 102 107  107  ASP ASP A . n 
A 1 103 ASP 103 108  108  ASP ASP A . n 
A 1 104 LYS 104 109  109  LYS LYS A . n 
A 1 105 THR 105 110  110  THR THR A . n 
A 1 106 LEU 106 111  111  LEU LEU A . n 
A 1 107 LYS 107 112  112  LYS LYS A . n 
A 1 108 ILE 108 113  113  ILE ILE A . n 
A 1 109 TRP 109 114  114  TRP TRP A . n 
A 1 110 ASP 110 115  115  ASP ASP A . n 
A 1 111 VAL 111 116  116  VAL VAL A . n 
A 1 112 SER 112 117  117  SER SER A . n 
A 1 113 SER 113 118  118  SER SER A . n 
A 1 114 GLY 114 119  119  GLY GLY A . n 
A 1 115 LYS 115 120  120  LYS LYS A . n 
A 1 116 CYS 116 121  121  CYS CYS A . n 
A 1 117 LEU 117 122  122  LEU LEU A . n 
A 1 118 LYS 118 123  123  LYS LYS A . n 
A 1 119 THR 119 124  124  THR THR A . n 
A 1 120 LEU 120 125  125  LEU LEU A . n 
A 1 121 LYS 121 126  126  LYS LYS A . n 
A 1 122 GLY 122 127  127  GLY GLY A . n 
A 1 123 HIS 123 128  128  HIS HIS A . n 
A 1 124 SER 124 129  129  SER SER A . n 
A 1 125 ASN 125 130  130  ASN ASN A . n 
A 1 126 TYR 126 131  131  TYR TYR A . n 
A 1 127 VAL 127 132  132  VAL VAL A . n 
A 1 128 PHE 128 133  133  PHE PHE A . n 
A 1 129 CYS 129 134  134  CYS CYS A . n 
A 1 130 CYS 130 135  135  CYS CYS A . n 
A 1 131 ASN 131 136  136  ASN ASN A . n 
A 1 132 PHE 132 137  137  PHE PHE A . n 
A 1 133 ASN 133 138  138  ASN ASN A . n 
A 1 134 PRO 134 139  139  PRO PRO A . n 
A 1 135 GLN 135 140  140  GLN GLN A . n 
A 1 136 SER 136 141  141  SER SER A . n 
A 1 137 ASN 137 142  142  ASN ASN A . n 
A 1 138 LEU 138 143  143  LEU LEU A . n 
A 1 139 ILE 139 144  144  ILE ILE A . n 
A 1 140 VAL 140 145  145  VAL VAL A . n 
A 1 141 SER 141 146  146  SER SER A . n 
A 1 142 GLY 142 147  147  GLY GLY A . n 
A 1 143 SER 143 148  148  SER SER A . n 
A 1 144 PHE 144 149  149  PHE PHE A . n 
A 1 145 ASP 145 150  150  ASP ASP A . n 
A 1 146 GLU 146 151  151  GLU GLU A . n 
A 1 147 SER 147 152  152  SER SER A . n 
A 1 148 VAL 148 153  153  VAL VAL A . n 
A 1 149 ARG 149 154  154  ARG ARG A . n 
A 1 150 ILE 150 155  155  ILE ILE A . n 
A 1 151 TRP 151 156  156  TRP TRP A . n 
A 1 152 ASP 152 157  157  ASP ASP A . n 
A 1 153 VAL 153 158  158  VAL VAL A . n 
A 1 154 LYS 154 159  159  LYS LYS A . n 
A 1 155 THR 155 160  160  THR THR A . n 
A 1 156 GLY 156 161  161  GLY GLY A . n 
A 1 157 LYS 157 162  162  LYS LYS A . n 
A 1 158 CYS 158 163  163  CYS CYS A . n 
A 1 159 LEU 159 164  164  LEU LEU A . n 
A 1 160 LYS 160 165  165  LYS LYS A . n 
A 1 161 THR 161 166  166  THR THR A . n 
A 1 162 LEU 162 167  167  LEU LEU A . n 
A 1 163 PRO 163 168  168  PRO PRO A . n 
A 1 164 ALA 164 169  169  ALA ALA A . n 
A 1 165 HIS 165 170  170  HIS HIS A . n 
A 1 166 SER 166 171  171  SER SER A . n 
A 1 167 ASP 167 172  172  ASP ASP A . n 
A 1 168 PRO 168 173  173  PRO PRO A . n 
A 1 169 VAL 169 174  174  VAL VAL A . n 
A 1 170 SER 170 175  175  SER SER A . n 
A 1 171 ALA 171 176  176  ALA ALA A . n 
A 1 172 VAL 172 177  177  VAL VAL A . n 
A 1 173 HIS 173 178  178  HIS HIS A . n 
A 1 174 PHE 174 179  179  PHE PHE A . n 
A 1 175 ASN 175 180  180  ASN ASN A . n 
A 1 176 ARG 176 181  181  ARG ARG A . n 
A 1 177 ASP 177 182  182  ASP ASP A . n 
A 1 178 GLY 178 183  183  GLY GLY A . n 
A 1 179 SER 179 184  184  SER SER A . n 
A 1 180 LEU 180 185  185  LEU LEU A . n 
A 1 181 ILE 181 186  186  ILE ILE A . n 
A 1 182 VAL 182 187  187  VAL VAL A . n 
A 1 183 SER 183 188  188  SER SER A . n 
A 1 184 SER 184 189  189  SER SER A . n 
A 1 185 SER 185 190  190  SER SER A . n 
A 1 186 TYR 186 191  191  TYR TYR A . n 
A 1 187 ASP 187 192  192  ASP ASP A . n 
A 1 188 GLY 188 193  193  GLY GLY A . n 
A 1 189 LEU 189 194  194  LEU LEU A . n 
A 1 190 CYS 190 195  195  CYS CYS A . n 
A 1 191 ARG 191 196  196  ARG ARG A . n 
A 1 192 ILE 192 197  197  ILE ILE A . n 
A 1 193 TRP 193 198  198  TRP TRP A . n 
A 1 194 ASP 194 199  199  ASP ASP A . n 
A 1 195 THR 195 200  200  THR THR A . n 
A 1 196 ALA 196 201  201  ALA ALA A . n 
A 1 197 SER 197 202  202  SER SER A . n 
A 1 198 GLY 198 203  203  GLY GLY A . n 
A 1 199 GLN 199 204  204  GLN GLN A . n 
A 1 200 CYS 200 205  205  CYS CYS A . n 
A 1 201 LEU 201 206  206  LEU LEU A . n 
A 1 202 LYS 202 207  207  LYS LYS A . n 
A 1 203 THR 203 208  208  THR THR A . n 
A 1 204 LEU 204 209  209  LEU LEU A . n 
A 1 205 ILE 205 210  210  ILE ILE A . n 
A 1 206 ASP 206 211  211  ASP ASP A . n 
A 1 207 ASP 207 212  212  ASP ASP A . n 
A 1 208 ASP 208 213  213  ASP ASP A . n 
A 1 209 ASN 209 214  214  ASN ASN A . n 
A 1 210 PRO 210 215  215  PRO PRO A . n 
A 1 211 PRO 211 216  216  PRO PRO A . n 
A 1 212 VAL 212 217  217  VAL VAL A . n 
A 1 213 SER 213 218  218  SER SER A . n 
A 1 214 PHE 214 219  219  PHE PHE A . n 
A 1 215 VAL 215 220  220  VAL VAL A . n 
A 1 216 LYS 216 221  221  LYS LYS A . n 
A 1 217 PHE 217 222  222  PHE PHE A . n 
A 1 218 SER 218 223  223  SER SER A . n 
A 1 219 PRO 219 224  224  PRO PRO A . n 
A 1 220 ASN 220 225  225  ASN ASN A . n 
A 1 221 GLY 221 226  226  GLY GLY A . n 
A 1 222 LYS 222 227  227  LYS LYS A . n 
A 1 223 TYR 223 228  228  TYR TYR A . n 
A 1 224 ILE 224 229  229  ILE ILE A . n 
A 1 225 LEU 225 230  230  LEU LEU A . n 
A 1 226 ALA 226 231  231  ALA ALA A . n 
A 1 227 ALA 227 232  232  ALA ALA A . n 
A 1 228 THR 228 233  233  THR THR A . n 
A 1 229 LEU 229 234  234  LEU LEU A . n 
A 1 230 ASP 230 235  235  ASP ASP A . n 
A 1 231 ASN 231 236  236  ASN ASN A . n 
A 1 232 THR 232 237  237  THR THR A . n 
A 1 233 LEU 233 238  238  LEU LEU A . n 
A 1 234 LYS 234 239  239  LYS LYS A . n 
A 1 235 LEU 235 240  240  LEU LEU A . n 
A 1 236 TRP 236 241  241  TRP TRP A . n 
A 1 237 ASP 237 242  242  ASP ASP A . n 
A 1 238 TYR 238 243  243  TYR TYR A . n 
A 1 239 SER 239 244  244  SER SER A . n 
A 1 240 LYS 240 245  245  LYS LYS A . n 
A 1 241 GLY 241 246  246  GLY GLY A . n 
A 1 242 LYS 242 247  247  LYS LYS A . n 
A 1 243 CYS 243 248  248  CYS CYS A . n 
A 1 244 LEU 244 249  249  LEU LEU A . n 
A 1 245 LYS 245 250  250  LYS LYS A . n 
A 1 246 THR 246 251  251  THR THR A . n 
A 1 247 TYR 247 252  252  TYR TYR A . n 
A 1 248 THR 248 253  253  THR THR A . n 
A 1 249 GLY 249 254  254  GLY GLY A . n 
A 1 250 HIS 250 255  255  HIS HIS A . n 
A 1 251 LYS 251 256  256  LYS LYS A . n 
A 1 252 ASN 252 257  257  ASN ASN A . n 
A 1 253 GLU 253 258  258  GLU GLU A . n 
A 1 254 LYS 254 259  259  LYS LYS A . n 
A 1 255 TYR 255 260  260  TYR TYR A . n 
A 1 256 CYS 256 261  261  CYS CYS A . n 
A 1 257 ILE 257 262  262  ILE ILE A . n 
A 1 258 PHE 258 263  263  PHE PHE A . n 
A 1 259 ALA 259 264  264  ALA ALA A . n 
A 1 260 ASN 260 265  265  ASN ASN A . n 
A 1 261 PHE 261 266  266  PHE PHE A . n 
A 1 262 SER 262 267  267  SER SER A . n 
A 1 263 VAL 263 268  268  VAL VAL A . n 
A 1 264 THR 264 269  269  THR THR A . n 
A 1 265 GLY 265 270  270  GLY GLY A . n 
A 1 266 GLY 266 271  271  GLY GLY A . n 
A 1 267 LYS 267 272  272  LYS LYS A . n 
A 1 268 TRP 268 273  273  TRP TRP A . n 
A 1 269 ILE 269 274  274  ILE ILE A . n 
A 1 270 VAL 270 275  275  VAL VAL A . n 
A 1 271 SER 271 276  276  SER SER A . n 
A 1 272 GLY 272 277  277  GLY GLY A . n 
A 1 273 SER 273 278  278  SER SER A . n 
A 1 274 GLU 274 279  279  GLU GLU A . n 
A 1 275 ASP 275 280  280  ASP ASP A . n 
A 1 276 ASN 276 281  281  ASN ASN A . n 
A 1 277 LEU 277 282  282  LEU LEU A . n 
A 1 278 VAL 278 283  283  VAL VAL A . n 
A 1 279 TYR 279 284  284  TYR TYR A . n 
A 1 280 ILE 280 285  285  ILE ILE A . n 
A 1 281 TRP 281 286  286  TRP TRP A . n 
A 1 282 ASN 282 287  287  ASN ASN A . n 
A 1 283 LEU 283 288  288  LEU LEU A . n 
A 1 284 GLN 284 289  289  GLN GLN A . n 
A 1 285 THR 285 290  290  THR THR A . n 
A 1 286 LYS 286 291  291  LYS LYS A . n 
A 1 287 GLU 287 292  292  GLU GLU A . n 
A 1 288 ILE 288 293  293  ILE ILE A . n 
A 1 289 VAL 289 294  294  VAL VAL A . n 
A 1 290 GLN 290 295  295  GLN GLN A . n 
A 1 291 LYS 291 296  296  LYS LYS A . n 
A 1 292 LEU 292 297  297  LEU LEU A . n 
A 1 293 GLN 293 298  298  GLN GLN A . n 
A 1 294 GLY 294 299  299  GLY GLY A . n 
A 1 295 HIS 295 300  300  HIS HIS A . n 
A 1 296 THR 296 301  301  THR THR A . n 
A 1 297 ASP 297 302  302  ASP ASP A . n 
A 1 298 VAL 298 303  303  VAL VAL A . n 
A 1 299 VAL 299 304  304  VAL VAL A . n 
A 1 300 ILE 300 305  305  ILE ILE A . n 
A 1 301 SER 301 306  306  SER SER A . n 
A 1 302 THR 302 307  307  THR THR A . n 
A 1 303 ALA 303 308  308  ALA ALA A . n 
A 1 304 CYS 304 309  309  CYS CYS A . n 
A 1 305 HIS 305 310  310  HIS HIS A . n 
A 1 306 PRO 306 311  311  PRO PRO A . n 
A 1 307 THR 307 312  312  THR THR A . n 
A 1 308 GLU 308 313  313  GLU GLU A . n 
A 1 309 ASN 309 314  314  ASN ASN A . n 
A 1 310 ILE 310 315  315  ILE ILE A . n 
A 1 311 ILE 311 316  316  ILE ILE A . n 
A 1 312 ALA 312 317  317  ALA ALA A . n 
A 1 313 SER 313 318  318  SER SER A . n 
A 1 314 ALA 314 319  319  ALA ALA A . n 
A 1 315 ALA 315 320  320  ALA ALA A . n 
A 1 316 LEU 316 321  321  LEU LEU A . n 
A 1 317 GLU 317 322  322  GLU GLU A . n 
A 1 318 ASN 318 323  323  ASN ASN A . n 
A 1 319 ASP 319 324  324  ASP ASP A . n 
A 1 320 LYS 320 325  325  LYS LYS A . n 
A 1 321 THR 321 326  326  THR THR A . n 
A 1 322 ILE 322 327  327  ILE ILE A . n 
A 1 323 LYS 323 328  328  LYS LYS A . n 
A 1 324 LEU 324 329  329  LEU LEU A . n 
A 1 325 TRP 325 330  330  TRP TRP A . n 
A 1 326 LYS 326 331  331  LYS LYS A . n 
A 1 327 SER 327 332  332  SER SER A . n 
A 1 328 ASP 328 333  333  ASP ASP A . n 
A 1 329 CYS 329 334  334  CYS CYS A . n 
B 2 1   MET 1   1053 ?    ?   ?   B . n 
B 2 2   GLY 2   1054 ?    ?   ?   B . n 
B 2 3   SER 3   1055 ?    ?   ?   B . n 
B 2 4   SER 4   1056 ?    ?   ?   B . n 
B 2 5   HIS 5   1057 ?    ?   ?   B . n 
B 2 6   HIS 6   1058 ?    ?   ?   B . n 
B 2 7   HIS 7   1059 ?    ?   ?   B . n 
B 2 8   HIS 8   1060 ?    ?   ?   B . n 
B 2 9   HIS 9   1061 ?    ?   ?   B . n 
B 2 10  HIS 10  1062 ?    ?   ?   B . n 
B 2 11  SER 11  1063 ?    ?   ?   B . n 
B 2 12  SER 12  1064 ?    ?   ?   B . n 
B 2 13  GLY 13  1065 ?    ?   ?   B . n 
B 2 14  ARG 14  1066 ?    ?   ?   B . n 
B 2 15  GLU 15  1067 ?    ?   ?   B . n 
B 2 16  ASN 16  1068 ?    ?   ?   B . n 
B 2 17  LEU 17  1069 ?    ?   ?   B . n 
B 2 18  TYR 18  1070 ?    ?   ?   B . n 
B 2 19  PHE 19  1071 ?    ?   ?   B . n 
B 2 20  GLN 20  1072 ?    ?   ?   B . n 
B 2 21  GLY 21  1073 ?    ?   ?   B . n 
B 2 22  SER 22  1074 ?    ?   ?   B . n 
B 2 23  SER 23  1075 ?    ?   ?   B . n 
B 2 24  ARG 24  1076 ?    ?   ?   B . n 
B 2 25  ALA 25  1077 ?    ?   ?   B . n 
B 2 26  SER 26  1078 ?    ?   ?   B . n 
B 2 27  ALA 27  1079 ?    ?   ?   B . n 
B 2 28  PHE 28  1080 1080 PHE PHE B . n 
B 2 29  ARG 29  1081 1081 ARG ARG B . n 
B 2 30  PRO 30  1082 1082 PRO PRO B . n 
B 2 31  ILE 31  1083 1083 ILE ILE B . n 
B 2 32  SER 32  1084 1084 SER SER B . n 
B 2 33  VAL 33  1085 1085 VAL VAL B . n 
B 2 34  PHE 34  1086 1086 PHE PHE B . n 
B 2 35  ARG 35  1087 1087 ARG ARG B . n 
B 2 36  GLU 36  1088 1088 GLU GLU B . n 
B 2 37  ALA 37  1089 1089 ALA ALA B . n 
B 2 38  ASN 38  1090 1090 ASN ASN B . n 
B 2 39  GLU 39  1091 1091 GLU GLU B . n 
B 2 40  ASP 40  1092 1092 ASP ASP B . n 
B 2 41  GLU 41  1093 1093 GLU GLU B . n 
B 2 42  SER 42  1094 1094 SER SER B . n 
B 2 43  GLY 43  1095 1095 GLY GLY B . n 
B 2 44  PHE 44  1096 1096 PHE PHE B . n 
B 2 45  THR 45  1097 1097 THR THR B . n 
B 2 46  CYS 46  1098 1098 CYS CYS B . n 
B 2 47  CYS 47  1099 1099 CYS CYS B . n 
B 2 48  ALA 48  1100 1100 ALA ALA B . n 
B 2 49  PHE 49  1101 1101 PHE PHE B . n 
B 2 50  SER 50  1102 1102 SER SER B . n 
B 2 51  ALA 51  1103 1103 ALA ALA B . n 
B 2 52  ARG 52  1104 1104 ARG ARG B . n 
B 2 53  GLU 53  1105 1105 GLU GLU B . n 
B 2 54  ARG 54  1106 1106 ARG ARG B . n 
B 2 55  PHE 55  1107 1107 PHE PHE B . n 
B 2 56  LEU 56  1108 1108 LEU LEU B . n 
B 2 57  MET 57  1109 1109 MET MET B . n 
B 2 58  LEU 58  1110 1110 LEU LEU B . n 
B 2 59  GLY 59  1111 1111 GLY GLY B . n 
B 2 60  THR 60  1112 1112 THR THR B . n 
B 2 61  CYS 61  1113 1113 CYS CYS B . n 
B 2 62  THR 62  1114 1114 THR THR B . n 
B 2 63  GLY 63  1115 1115 GLY GLY B . n 
B 2 64  GLN 64  1116 1116 GLN GLN B . n 
B 2 65  LEU 65  1117 1117 LEU LEU B . n 
B 2 66  LYS 66  1118 1118 LYS LYS B . n 
B 2 67  LEU 67  1119 1119 LEU LEU B . n 
B 2 68  TYR 68  1120 1120 TYR TYR B . n 
B 2 69  ASN 69  1121 1121 ASN ASN B . n 
B 2 70  VAL 70  1122 1122 VAL VAL B . n 
B 2 71  PHE 71  1123 1123 PHE PHE B . n 
B 2 72  SER 72  1124 1124 SER SER B . n 
B 2 73  GLY 73  1125 1125 GLY GLY B . n 
B 2 74  GLN 74  1126 1126 GLN GLN B . n 
B 2 75  GLU 75  1127 1127 GLU GLU B . n 
B 2 76  GLU 76  1128 1128 GLU GLU B . n 
B 2 77  ALA 77  1129 1129 ALA ALA B . n 
B 2 78  SER 78  1130 1130 SER SER B . n 
B 2 79  TYR 79  1131 1131 TYR TYR B . n 
B 2 80  ASN 80  1132 1132 ASN ASN B . n 
B 2 81  CYS 81  1133 1133 CYS CYS B . n 
B 2 82  HIS 82  1134 1134 HIS HIS B . n 
B 2 83  ASN 83  1135 1135 ASN ASN B . n 
B 2 84  SER 84  1136 1136 SER SER B . n 
B 2 85  ALA 85  1137 1137 ALA ALA B . n 
B 2 86  ILE 86  1138 1138 ILE ILE B . n 
B 2 87  THR 87  1139 1139 THR THR B . n 
B 2 88  HIS 88  1140 1140 HIS HIS B . n 
B 2 89  LEU 89  1141 1141 LEU LEU B . n 
B 2 90  GLU 90  1142 1142 GLU GLU B . n 
B 2 91  PRO 91  1143 1143 PRO PRO B . n 
B 2 92  SER 92  1144 1144 SER SER B . n 
B 2 93  ARG 93  1145 1145 ARG ARG B . n 
B 2 94  ASP 94  1146 1146 ASP ASP B . n 
B 2 95  GLY 95  1147 1147 GLY GLY B . n 
B 2 96  SER 96  1148 1148 SER SER B . n 
B 2 97  LEU 97  1149 1149 LEU LEU B . n 
B 2 98  LEU 98  1150 1150 LEU LEU B . n 
B 2 99  LEU 99  1151 1151 LEU LEU B . n 
B 2 100 THR 100 1152 1152 THR THR B . n 
B 2 101 SER 101 1153 1153 SER SER B . n 
B 2 102 ALA 102 1154 1154 ALA ALA B . n 
B 2 103 THR 103 1155 1155 THR THR B . n 
B 2 104 TRP 104 1156 1156 TRP TRP B . n 
B 2 105 SER 105 1157 1157 SER SER B . n 
B 2 106 GLN 106 1158 1158 GLN GLN B . n 
B 2 107 PRO 107 1159 1159 PRO PRO B . n 
B 2 108 LEU 108 1160 1160 LEU LEU B . n 
B 2 109 SER 109 1161 1161 SER SER B . n 
B 2 110 ALA 110 1162 1162 ALA ALA B . n 
B 2 111 LEU 111 1163 1163 LEU LEU B . n 
B 2 112 TRP 112 1164 1164 TRP TRP B . n 
B 2 113 GLY 113 1165 1165 GLY GLY B . n 
B 2 114 MET 114 1166 1166 MET MET B . n 
B 2 115 LYS 115 1167 1167 LYS LYS B . n 
B 2 116 SER 116 1168 1168 SER SER B . n 
B 2 117 VAL 117 1169 1169 VAL VAL B . n 
B 2 118 PHE 118 1170 1170 PHE PHE B . n 
B 2 119 ASP 119 1171 1171 ASP ASP B . n 
B 2 120 MET 120 1172 1172 MET MET B . n 
B 2 121 LYS 121 1173 1173 LYS LYS B . n 
B 2 122 HIS 122 1174 1174 HIS HIS B . n 
B 2 123 SER 123 1175 1175 SER SER B . n 
B 2 124 PHE 124 1176 1176 PHE PHE B . n 
B 2 125 THR 125 1177 1177 THR THR B . n 
B 2 126 GLU 126 1178 1178 GLU GLU B . n 
B 2 127 ASP 127 1179 1179 ASP ASP B . n 
B 2 128 HIS 128 1180 1180 HIS HIS B . n 
B 2 129 TYR 129 1181 1181 TYR TYR B . n 
B 2 130 VAL 130 1182 1182 VAL VAL B . n 
B 2 131 GLU 131 1183 1183 GLU GLU B . n 
B 2 132 PHE 132 1184 1184 PHE PHE B . n 
B 2 133 SER 133 1185 1185 SER SER B . n 
B 2 134 LYS 134 1186 1186 LYS LYS B . n 
B 2 135 HIS 135 1187 1187 HIS HIS B . n 
B 2 136 SER 136 1188 1188 SER SER B . n 
B 2 137 GLN 137 1189 1189 GLN GLN B . n 
B 2 138 ASP 138 1190 1190 ASP ASP B . n 
B 2 139 ARG 139 1191 1191 ARG ARG B . n 
B 2 140 VAL 140 1192 1192 VAL VAL B . n 
B 2 141 ILE 141 1193 1193 ILE ILE B . n 
B 2 142 GLY 142 1194 1194 GLY GLY B . n 
B 2 143 THR 143 1195 1195 THR THR B . n 
B 2 144 LYS 144 1196 1196 LYS LYS B . n 
B 2 145 GLY 145 1197 1197 GLY GLY B . n 
B 2 146 ASP 146 1198 1198 ASP ASP B . n 
B 2 147 ILE 147 1199 1199 ILE ILE B . n 
B 2 148 ALA 148 1200 1200 ALA ALA B . n 
B 2 149 HIS 149 1201 1201 HIS HIS B . n 
B 2 150 ILE 150 1202 1202 ILE ILE B . n 
B 2 151 TYR 151 1203 1203 TYR TYR B . n 
B 2 152 ASP 152 1204 1204 ASP ASP B . n 
B 2 153 ILE 153 1205 1205 ILE ILE B . n 
B 2 154 GLN 154 1206 1206 GLN GLN B . n 
B 2 155 THR 155 1207 1207 THR THR B . n 
B 2 156 GLY 156 1208 1208 GLY GLY B . n 
B 2 157 ASN 157 1209 1209 ASN ASN B . n 
B 2 158 LYS 158 1210 1210 LYS LYS B . n 
B 2 159 LEU 159 1211 1211 LEU LEU B . n 
B 2 160 LEU 160 1212 1212 LEU LEU B . n 
B 2 161 THR 161 1213 1213 THR THR B . n 
B 2 162 LEU 162 1214 1214 LEU LEU B . n 
B 2 163 PHE 163 1215 1215 PHE PHE B . n 
B 2 164 ASN 164 1216 1216 ASN ASN B . n 
B 2 165 PRO 165 1217 1217 PRO PRO B . n 
B 2 166 ASP 166 1218 1218 ASP ASP B . n 
B 2 167 LEU 167 1219 1219 LEU LEU B . n 
B 2 168 ALA 168 1220 1220 ALA ALA B . n 
B 2 169 ASN 169 1221 1221 ASN ASN B . n 
B 2 170 ASN 170 1222 1222 ASN ASN B . n 
B 2 171 TYR 171 1223 1223 TYR TYR B . n 
B 2 172 LYS 172 1224 1224 LYS LYS B . n 
B 2 173 ARG 173 1225 1225 ARG ARG B . n 
B 2 174 ASN 174 1226 1226 ASN ASN B . n 
B 2 175 CYS 175 1227 1227 CYS CYS B . n 
B 2 176 ALA 176 1228 1228 ALA ALA B . n 
B 2 177 THR 177 1229 1229 THR THR B . n 
B 2 178 PHE 178 1230 1230 PHE PHE B . n 
B 2 179 ASN 179 1231 1231 ASN ASN B . n 
B 2 180 PRO 180 1232 1232 PRO PRO B . n 
B 2 181 THR 181 1233 1233 THR THR B . n 
B 2 182 ASP 182 1234 1234 ASP ASP B . n 
B 2 183 ASP 183 1235 1235 ASP ASP B . n 
B 2 184 LEU 184 1236 1236 LEU LEU B . n 
B 2 185 VAL 185 1237 1237 VAL VAL B . n 
B 2 186 LEU 186 1238 1238 LEU LEU B . n 
B 2 187 ASN 187 1239 1239 ASN ASN B . n 
B 2 188 ASP 188 1240 1240 ASP ASP B . n 
B 2 189 GLY 189 1241 1241 GLY GLY B . n 
B 2 190 VAL 190 1242 1242 VAL VAL B . n 
B 2 191 LEU 191 1243 1243 LEU LEU B . n 
B 2 192 TRP 192 1244 1244 TRP TRP B . n 
B 2 193 ASP 193 1245 1245 ASP ASP B . n 
B 2 194 VAL 194 1246 1246 VAL VAL B . n 
B 2 195 ARG 195 1247 1247 ARG ARG B . n 
B 2 196 SER 196 1248 1248 SER SER B . n 
B 2 197 ALA 197 1249 1249 ALA ALA B . n 
B 2 198 GLN 198 1250 1250 GLN GLN B . n 
B 2 199 ALA 199 1251 1251 ALA ALA B . n 
B 2 200 ILE 200 1252 1252 ILE ILE B . n 
B 2 201 HIS 201 1253 1253 HIS HIS B . n 
B 2 202 LYS 202 1254 1254 LYS LYS B . n 
B 2 203 PHE 203 1255 1255 PHE PHE B . n 
B 2 204 ASP 204 1256 1256 ASP ASP B . n 
B 2 205 LYS 205 1257 1257 LYS LYS B . n 
B 2 206 PHE 206 1258 1258 PHE PHE B . n 
B 2 207 ASN 207 1259 1259 ASN ASN B . n 
B 2 208 MET 208 1260 1260 MET MET B . n 
B 2 209 ASN 209 1261 1261 ASN ASN B . n 
B 2 210 ILE 210 1262 1262 ILE ILE B . n 
B 2 211 SER 211 1263 1263 SER SER B . n 
B 2 212 GLY 212 1264 1264 GLY GLY B . n 
B 2 213 VAL 213 1265 1265 VAL VAL B . n 
B 2 214 PHE 214 1266 1266 PHE PHE B . n 
B 2 215 HIS 215 1267 1267 HIS HIS B . n 
B 2 216 PRO 216 1268 1268 PRO PRO B . n 
B 2 217 ASN 217 1269 1269 ASN ASN B . n 
B 2 218 GLY 218 1270 1270 GLY GLY B . n 
B 2 219 LEU 219 1271 1271 LEU LEU B . n 
B 2 220 GLU 220 1272 1272 GLU GLU B . n 
B 2 221 VAL 221 1273 1273 VAL VAL B . n 
B 2 222 ILE 222 1274 1274 ILE ILE B . n 
B 2 223 ILE 223 1275 1275 ILE ILE B . n 
B 2 224 ASN 224 1276 1276 ASN ASN B . n 
B 2 225 THR 225 1277 1277 THR THR B . n 
B 2 226 GLU 226 1278 1278 GLU GLU B . n 
B 2 227 ILE 227 1279 1279 ILE ILE B . n 
B 2 228 TRP 228 1280 1280 TRP TRP B . n 
B 2 229 ASP 229 1281 1281 ASP ASP B . n 
B 2 230 LEU 230 1282 1282 LEU LEU B . n 
B 2 231 ARG 231 1283 1283 ARG ARG B . n 
B 2 232 THR 232 1284 1284 THR THR B . n 
B 2 233 PHE 233 1285 1285 PHE PHE B . n 
B 2 234 HIS 234 1286 1286 HIS HIS B . n 
B 2 235 LEU 235 1287 1287 LEU LEU B . n 
B 2 236 LEU 236 1288 1288 LEU LEU B . n 
B 2 237 HIS 237 1289 1289 HIS HIS B . n 
B 2 238 THR 238 1290 1290 THR THR B . n 
B 2 239 VAL 239 1291 1291 VAL VAL B . n 
B 2 240 PRO 240 1292 1292 PRO PRO B . n 
B 2 241 ALA 241 1293 1293 ALA ALA B . n 
B 2 242 LEU 242 1294 1294 LEU LEU B . n 
B 2 243 ASP 243 1295 1295 ASP ASP B . n 
B 2 244 GLN 244 1296 1296 GLN GLN B . n 
B 2 245 CYS 245 1297 1297 CYS CYS B . n 
B 2 246 ARG 246 1298 1298 ARG ARG B . n 
B 2 247 VAL 247 1299 1299 VAL VAL B . n 
B 2 248 VAL 248 1300 1300 VAL VAL B . n 
B 2 249 PHE 249 1301 1301 PHE PHE B . n 
B 2 250 ASN 250 1302 1302 ASN ASN B . n 
B 2 251 HIS 251 1303 1303 HIS HIS B . n 
B 2 252 THR 252 1304 1304 THR THR B . n 
B 2 253 GLY 253 1305 1305 GLY GLY B . n 
B 2 254 THR 254 1306 1306 THR THR B . n 
B 2 255 VAL 255 1307 1307 VAL VAL B . n 
B 2 256 MET 256 1308 1308 MET MET B . n 
B 2 257 TYR 257 1309 1309 TYR TYR B . n 
B 2 258 GLY 258 1310 1310 GLY GLY B . n 
B 2 259 ALA 259 1311 1311 ALA ALA B . n 
B 2 260 MET 260 1312 1312 MET MET B . n 
B 2 261 LEU 261 1313 1313 LEU LEU B . n 
B 2 262 GLN 262 1314 1314 GLN GLN B . n 
B 2 263 ALA 263 1315 1315 ALA ALA B . n 
B 2 264 ASP 264 1316 1316 ASP ASP B . n 
B 2 265 ASP 265 1317 ?    ?   ?   B . n 
B 2 266 GLU 266 1318 ?    ?   ?   B . n 
B 2 267 ASP 267 1319 ?    ?   ?   B . n 
B 2 268 ASP 268 1320 ?    ?   ?   B . n 
B 2 269 LEU 269 1321 ?    ?   ?   B . n 
B 2 270 MET 270 1322 ?    ?   ?   B . n 
B 2 271 GLU 271 1323 ?    ?   ?   B . n 
B 2 272 GLU 272 1324 ?    ?   ?   B . n 
B 2 273 ARG 273 1325 ?    ?   ?   B . n 
B 2 274 MET 274 1326 ?    ?   ?   B . n 
B 2 275 LYS 275 1327 1327 LYS LYS B . n 
B 2 276 SER 276 1328 1328 SER SER B . n 
B 2 277 PRO 277 1329 1329 PRO PRO B . n 
B 2 278 PHE 278 1330 1330 PHE PHE B . n 
B 2 279 GLY 279 1331 1331 GLY GLY B . n 
B 2 280 SER 280 1332 1332 SER SER B . n 
B 2 281 SER 281 1333 1333 SER SER B . n 
B 2 282 PHE 282 1334 1334 PHE PHE B . n 
B 2 283 ARG 283 1335 1335 ARG ARG B . n 
B 2 284 THR 284 1336 1336 THR THR B . n 
B 2 285 PHE 285 1337 1337 PHE PHE B . n 
B 2 286 ASN 286 1338 1338 ASN ASN B . n 
B 2 287 ALA 287 1339 1339 ALA ALA B . n 
B 2 288 THR 288 1340 1340 THR THR B . n 
B 2 289 ASP 289 1341 1341 ASP ASP B . n 
B 2 290 TYR 290 1342 1342 TYR TYR B . n 
B 2 291 LYS 291 1343 1343 LYS LYS B . n 
B 2 292 PRO 292 1344 1344 PRO PRO B . n 
B 2 293 ILE 293 1345 1345 ILE ILE B . n 
B 2 294 ALA 294 1346 1346 ALA ALA B . n 
B 2 295 THR 295 1347 1347 THR THR B . n 
B 2 296 ILE 296 1348 1348 ILE ILE B . n 
B 2 297 ASP 297 1349 1349 ASP ASP B . n 
B 2 298 VAL 298 1350 1350 VAL VAL B . n 
B 2 299 LYS 299 1351 1351 LYS LYS B . n 
B 2 300 ARG 300 1352 1352 ARG ARG B . n 
B 2 301 ASN 301 1353 1353 ASN ASN B . n 
B 2 302 ILE 302 1354 1354 ILE ILE B . n 
B 2 303 PHE 303 1355 1355 PHE PHE B . n 
B 2 304 ASP 304 1356 1356 ASP ASP B . n 
B 2 305 LEU 305 1357 1357 LEU LEU B . n 
B 2 306 CYS 306 1358 1358 CYS CYS B . n 
B 2 307 THR 307 1359 1359 THR THR B . n 
B 2 308 ASP 308 1360 1360 ASP ASP B . n 
B 2 309 THR 309 1361 1361 THR THR B . n 
B 2 310 LYS 310 1362 1362 LYS LYS B . n 
B 2 311 ASP 311 1363 1363 ASP ASP B . n 
B 2 312 CYS 312 1364 1364 CYS CYS B . n 
B 2 313 TYR 313 1365 1365 TYR TYR B . n 
B 2 314 LEU 314 1366 1366 LEU LEU B . n 
B 2 315 ALA 315 1367 1367 ALA ALA B . n 
B 2 316 VAL 316 1368 1368 VAL VAL B . n 
B 2 317 ILE 317 1369 1369 ILE ILE B . n 
B 2 318 GLU 318 1370 1370 GLU GLU B . n 
B 2 319 ASN 319 1371 1371 ASN ASN B . n 
B 2 320 GLN 320 1372 1372 GLN GLN B . n 
B 2 321 GLY 321 1373 1373 GLY GLY B . n 
B 2 322 SER 322 1374 1374 SER SER B . n 
B 2 323 MET 323 1375 1375 MET MET B . n 
B 2 324 ASP 324 1376 1376 ASP ASP B . n 
B 2 325 ALA 325 1377 1377 ALA ALA B . n 
B 2 326 LEU 326 1378 1378 LEU LEU B . n 
B 2 327 ASN 327 1379 1379 ASN ASN B . n 
B 2 328 MET 328 1380 1380 MET MET B . n 
B 2 329 ASP 329 1381 1381 ASP ASP B . n 
B 2 330 THR 330 1382 1382 THR THR B . n 
B 2 331 VAL 331 1383 1383 VAL VAL B . n 
B 2 332 CYS 332 1384 1384 CYS CYS B . n 
B 2 333 ARG 333 1385 1385 ARG ARG B . n 
B 2 334 LEU 334 1386 1386 LEU LEU B . n 
B 2 335 TYR 335 1387 1387 TYR TYR B . n 
B 2 336 GLU 336 1388 1388 GLU GLU B . n 
B 2 337 VAL 337 1389 1389 VAL VAL B . n 
B 2 338 GLY 338 1390 1390 GLY GLY B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1ANN 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1ANN 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 A1ANN 1   1401 1401 A1ANN UNK A . 
D 4 HOH   1   1501 296  HOH   HOH A . 
D 4 HOH   2   1502 65   HOH   HOH A . 
D 4 HOH   3   1503 456  HOH   HOH A . 
D 4 HOH   4   1504 360  HOH   HOH A . 
D 4 HOH   5   1505 117  HOH   HOH A . 
D 4 HOH   6   1506 275  HOH   HOH A . 
D 4 HOH   7   1507 37   HOH   HOH A . 
D 4 HOH   8   1508 33   HOH   HOH A . 
D 4 HOH   9   1509 221  HOH   HOH A . 
D 4 HOH   10  1510 193  HOH   HOH A . 
D 4 HOH   11  1511 111  HOH   HOH A . 
D 4 HOH   12  1512 255  HOH   HOH A . 
D 4 HOH   13  1513 35   HOH   HOH A . 
D 4 HOH   14  1514 126  HOH   HOH A . 
D 4 HOH   15  1515 107  HOH   HOH A . 
D 4 HOH   16  1516 121  HOH   HOH A . 
D 4 HOH   17  1517 306  HOH   HOH A . 
D 4 HOH   18  1518 388  HOH   HOH A . 
D 4 HOH   19  1519 276  HOH   HOH A . 
D 4 HOH   20  1520 119  HOH   HOH A . 
D 4 HOH   21  1521 289  HOH   HOH A . 
D 4 HOH   22  1522 428  HOH   HOH A . 
D 4 HOH   23  1523 95   HOH   HOH A . 
D 4 HOH   24  1524 423  HOH   HOH A . 
D 4 HOH   25  1525 231  HOH   HOH A . 
D 4 HOH   26  1526 491  HOH   HOH A . 
D 4 HOH   27  1527 136  HOH   HOH A . 
D 4 HOH   28  1528 169  HOH   HOH A . 
D 4 HOH   29  1529 93   HOH   HOH A . 
D 4 HOH   30  1530 133  HOH   HOH A . 
D 4 HOH   31  1531 214  HOH   HOH A . 
D 4 HOH   32  1532 277  HOH   HOH A . 
D 4 HOH   33  1533 162  HOH   HOH A . 
D 4 HOH   34  1534 46   HOH   HOH A . 
D 4 HOH   35  1535 25   HOH   HOH A . 
D 4 HOH   36  1536 3    HOH   HOH A . 
D 4 HOH   37  1537 299  HOH   HOH A . 
D 4 HOH   38  1538 394  HOH   HOH A . 
D 4 HOH   39  1539 101  HOH   HOH A . 
D 4 HOH   40  1540 118  HOH   HOH A . 
D 4 HOH   41  1541 58   HOH   HOH A . 
D 4 HOH   42  1542 354  HOH   HOH A . 
D 4 HOH   43  1543 201  HOH   HOH A . 
D 4 HOH   44  1544 109  HOH   HOH A . 
D 4 HOH   45  1545 12   HOH   HOH A . 
D 4 HOH   46  1546 72   HOH   HOH A . 
D 4 HOH   47  1547 7    HOH   HOH A . 
D 4 HOH   48  1548 147  HOH   HOH A . 
D 4 HOH   49  1549 86   HOH   HOH A . 
D 4 HOH   50  1550 268  HOH   HOH A . 
D 4 HOH   51  1551 243  HOH   HOH A . 
D 4 HOH   52  1552 5    HOH   HOH A . 
D 4 HOH   53  1553 60   HOH   HOH A . 
D 4 HOH   54  1554 19   HOH   HOH A . 
D 4 HOH   55  1555 14   HOH   HOH A . 
D 4 HOH   56  1556 67   HOH   HOH A . 
D 4 HOH   57  1557 298  HOH   HOH A . 
D 4 HOH   58  1558 105  HOH   HOH A . 
D 4 HOH   59  1559 273  HOH   HOH A . 
D 4 HOH   60  1560 99   HOH   HOH A . 
D 4 HOH   61  1561 18   HOH   HOH A . 
D 4 HOH   62  1562 174  HOH   HOH A . 
D 4 HOH   63  1563 17   HOH   HOH A . 
D 4 HOH   64  1564 106  HOH   HOH A . 
D 4 HOH   65  1565 176  HOH   HOH A . 
D 4 HOH   66  1566 48   HOH   HOH A . 
D 4 HOH   67  1567 309  HOH   HOH A . 
D 4 HOH   68  1568 104  HOH   HOH A . 
D 4 HOH   69  1569 189  HOH   HOH A . 
D 4 HOH   70  1570 182  HOH   HOH A . 
D 4 HOH   71  1571 113  HOH   HOH A . 
D 4 HOH   72  1572 404  HOH   HOH A . 
D 4 HOH   73  1573 61   HOH   HOH A . 
D 4 HOH   74  1574 152  HOH   HOH A . 
D 4 HOH   75  1575 139  HOH   HOH A . 
D 4 HOH   76  1576 128  HOH   HOH A . 
D 4 HOH   77  1577 143  HOH   HOH A . 
D 4 HOH   78  1578 38   HOH   HOH A . 
D 4 HOH   79  1579 4    HOH   HOH A . 
D 4 HOH   80  1580 320  HOH   HOH A . 
D 4 HOH   81  1581 16   HOH   HOH A . 
D 4 HOH   82  1582 130  HOH   HOH A . 
D 4 HOH   83  1583 145  HOH   HOH A . 
D 4 HOH   84  1584 211  HOH   HOH A . 
D 4 HOH   85  1585 129  HOH   HOH A . 
D 4 HOH   86  1586 490  HOH   HOH A . 
D 4 HOH   87  1587 230  HOH   HOH A . 
D 4 HOH   88  1588 6    HOH   HOH A . 
D 4 HOH   89  1589 137  HOH   HOH A . 
D 4 HOH   90  1590 75   HOH   HOH A . 
D 4 HOH   91  1591 53   HOH   HOH A . 
D 4 HOH   92  1592 62   HOH   HOH A . 
D 4 HOH   93  1593 253  HOH   HOH A . 
D 4 HOH   94  1594 76   HOH   HOH A . 
D 4 HOH   95  1595 197  HOH   HOH A . 
D 4 HOH   96  1596 443  HOH   HOH A . 
D 4 HOH   97  1597 89   HOH   HOH A . 
D 4 HOH   98  1598 2    HOH   HOH A . 
D 4 HOH   99  1599 229  HOH   HOH A . 
D 4 HOH   100 1600 82   HOH   HOH A . 
D 4 HOH   101 1601 123  HOH   HOH A . 
D 4 HOH   102 1602 28   HOH   HOH A . 
D 4 HOH   103 1603 357  HOH   HOH A . 
D 4 HOH   104 1604 90   HOH   HOH A . 
D 4 HOH   105 1605 210  HOH   HOH A . 
D 4 HOH   106 1606 23   HOH   HOH A . 
D 4 HOH   107 1607 81   HOH   HOH A . 
D 4 HOH   108 1608 218  HOH   HOH A . 
D 4 HOH   109 1609 228  HOH   HOH A . 
D 4 HOH   110 1610 45   HOH   HOH A . 
D 4 HOH   111 1611 22   HOH   HOH A . 
D 4 HOH   112 1612 64   HOH   HOH A . 
D 4 HOH   113 1613 20   HOH   HOH A . 
D 4 HOH   114 1614 205  HOH   HOH A . 
D 4 HOH   115 1615 262  HOH   HOH A . 
D 4 HOH   116 1616 254  HOH   HOH A . 
D 4 HOH   117 1617 102  HOH   HOH A . 
D 4 HOH   118 1618 92   HOH   HOH A . 
D 4 HOH   119 1619 198  HOH   HOH A . 
D 4 HOH   120 1620 402  HOH   HOH A . 
D 4 HOH   121 1621 173  HOH   HOH A . 
D 4 HOH   122 1622 396  HOH   HOH A . 
D 4 HOH   123 1623 313  HOH   HOH A . 
D 4 HOH   124 1624 141  HOH   HOH A . 
D 4 HOH   125 1625 149  HOH   HOH A . 
D 4 HOH   126 1626 103  HOH   HOH A . 
D 4 HOH   127 1627 186  HOH   HOH A . 
D 4 HOH   128 1628 87   HOH   HOH A . 
D 4 HOH   129 1629 44   HOH   HOH A . 
D 4 HOH   130 1630 461  HOH   HOH A . 
D 4 HOH   131 1631 63   HOH   HOH A . 
D 4 HOH   132 1632 54   HOH   HOH A . 
D 4 HOH   133 1633 41   HOH   HOH A . 
D 4 HOH   134 1634 454  HOH   HOH A . 
D 4 HOH   135 1635 389  HOH   HOH A . 
D 4 HOH   136 1636 91   HOH   HOH A . 
D 4 HOH   137 1637 157  HOH   HOH A . 
D 4 HOH   138 1638 377  HOH   HOH A . 
D 4 HOH   139 1639 430  HOH   HOH A . 
D 4 HOH   140 1640 85   HOH   HOH A . 
D 4 HOH   141 1641 247  HOH   HOH A . 
D 4 HOH   142 1642 183  HOH   HOH A . 
D 4 HOH   143 1643 74   HOH   HOH A . 
D 4 HOH   144 1644 209  HOH   HOH A . 
D 4 HOH   145 1645 301  HOH   HOH A . 
D 4 HOH   146 1646 150  HOH   HOH A . 
D 4 HOH   147 1647 249  HOH   HOH A . 
D 4 HOH   148 1648 242  HOH   HOH A . 
D 4 HOH   149 1649 458  HOH   HOH A . 
D 4 HOH   150 1650 13   HOH   HOH A . 
D 4 HOH   151 1651 355  HOH   HOH A . 
D 4 HOH   152 1652 333  HOH   HOH A . 
D 4 HOH   153 1653 227  HOH   HOH A . 
D 4 HOH   154 1654 170  HOH   HOH A . 
D 4 HOH   155 1655 190  HOH   HOH A . 
D 4 HOH   156 1656 293  HOH   HOH A . 
D 4 HOH   157 1657 234  HOH   HOH A . 
D 4 HOH   158 1658 451  HOH   HOH A . 
D 4 HOH   159 1659 269  HOH   HOH A . 
D 4 HOH   160 1660 382  HOH   HOH A . 
D 4 HOH   161 1661 305  HOH   HOH A . 
D 4 HOH   162 1662 134  HOH   HOH A . 
D 4 HOH   163 1663 212  HOH   HOH A . 
D 4 HOH   164 1664 100  HOH   HOH A . 
D 4 HOH   165 1665 8    HOH   HOH A . 
D 4 HOH   166 1666 336  HOH   HOH A . 
D 4 HOH   167 1667 327  HOH   HOH A . 
D 4 HOH   168 1668 368  HOH   HOH A . 
D 4 HOH   169 1669 124  HOH   HOH A . 
D 4 HOH   170 1670 263  HOH   HOH A . 
D 4 HOH   171 1671 171  HOH   HOH A . 
D 4 HOH   172 1672 148  HOH   HOH A . 
D 4 HOH   173 1673 73   HOH   HOH A . 
D 4 HOH   174 1674 291  HOH   HOH A . 
D 4 HOH   175 1675 167  HOH   HOH A . 
D 4 HOH   176 1676 416  HOH   HOH A . 
D 4 HOH   177 1677 485  HOH   HOH A . 
D 4 HOH   178 1678 347  HOH   HOH A . 
D 4 HOH   179 1679 365  HOH   HOH A . 
D 4 HOH   180 1680 202  HOH   HOH A . 
D 4 HOH   181 1681 425  HOH   HOH A . 
D 4 HOH   182 1682 324  HOH   HOH A . 
D 4 HOH   183 1683 307  HOH   HOH A . 
D 4 HOH   184 1684 203  HOH   HOH A . 
D 4 HOH   185 1685 135  HOH   HOH A . 
D 4 HOH   186 1686 11   HOH   HOH A . 
D 4 HOH   187 1687 363  HOH   HOH A . 
D 4 HOH   188 1688 477  HOH   HOH A . 
D 4 HOH   189 1689 362  HOH   HOH A . 
D 4 HOH   190 1690 290  HOH   HOH A . 
D 4 HOH   191 1691 140  HOH   HOH A . 
D 4 HOH   192 1692 481  HOH   HOH A . 
D 4 HOH   193 1693 343  HOH   HOH A . 
D 4 HOH   194 1694 446  HOH   HOH A . 
D 4 HOH   195 1695 144  HOH   HOH A . 
D 4 HOH   196 1696 463  HOH   HOH A . 
D 4 HOH   197 1697 127  HOH   HOH A . 
D 4 HOH   198 1698 348  HOH   HOH A . 
D 4 HOH   199 1699 225  HOH   HOH A . 
D 4 HOH   200 1700 392  HOH   HOH A . 
D 4 HOH   201 1701 322  HOH   HOH A . 
D 4 HOH   202 1702 165  HOH   HOH A . 
D 4 HOH   203 1703 447  HOH   HOH A . 
D 4 HOH   204 1704 59   HOH   HOH A . 
D 4 HOH   205 1705 222  HOH   HOH A . 
D 4 HOH   206 1706 311  HOH   HOH A . 
D 4 HOH   207 1707 421  HOH   HOH A . 
D 4 HOH   208 1708 332  HOH   HOH A . 
D 4 HOH   209 1709 319  HOH   HOH A . 
D 4 HOH   210 1710 279  HOH   HOH A . 
D 4 HOH   211 1711 323  HOH   HOH A . 
D 4 HOH   212 1712 376  HOH   HOH A . 
D 4 HOH   213 1713 326  HOH   HOH A . 
D 4 HOH   214 1714 108  HOH   HOH A . 
D 4 HOH   215 1715 331  HOH   HOH A . 
D 4 HOH   216 1716 494  HOH   HOH A . 
D 4 HOH   217 1717 469  HOH   HOH A . 
D 4 HOH   218 1718 445  HOH   HOH A . 
D 4 HOH   219 1719 408  HOH   HOH A . 
D 4 HOH   220 1720 278  HOH   HOH A . 
D 4 HOH   221 1721 334  HOH   HOH A . 
D 4 HOH   222 1722 281  HOH   HOH A . 
D 4 HOH   223 1723 413  HOH   HOH A . 
D 4 HOH   224 1724 417  HOH   HOH A . 
D 4 HOH   225 1725 495  HOH   HOH A . 
D 4 HOH   226 1726 476  HOH   HOH A . 
D 4 HOH   227 1727 216  HOH   HOH A . 
D 4 HOH   228 1728 265  HOH   HOH A . 
D 4 HOH   229 1729 488  HOH   HOH A . 
D 4 HOH   230 1730 432  HOH   HOH A . 
D 4 HOH   231 1731 316  HOH   HOH A . 
D 4 HOH   232 1732 433  HOH   HOH A . 
D 4 HOH   233 1733 358  HOH   HOH A . 
D 4 HOH   234 1734 483  HOH   HOH A . 
D 4 HOH   235 1735 361  HOH   HOH A . 
D 4 HOH   236 1736 384  HOH   HOH A . 
D 4 HOH   237 1737 294  HOH   HOH A . 
D 4 HOH   238 1738 435  HOH   HOH A . 
D 4 HOH   239 1739 114  HOH   HOH A . 
D 4 HOH   240 1740 244  HOH   HOH A . 
D 4 HOH   241 1741 422  HOH   HOH A . 
D 4 HOH   242 1742 466  HOH   HOH A . 
D 4 HOH   243 1743 340  HOH   HOH A . 
D 4 HOH   244 1744 353  HOH   HOH A . 
D 4 HOH   245 1745 405  HOH   HOH A . 
D 4 HOH   246 1746 325  HOH   HOH A . 
D 4 HOH   247 1747 438  HOH   HOH A . 
D 4 HOH   248 1748 393  HOH   HOH A . 
D 4 HOH   249 1749 329  HOH   HOH A . 
D 4 HOH   250 1750 256  HOH   HOH A . 
D 4 HOH   251 1751 406  HOH   HOH A . 
D 4 HOH   252 1752 163  HOH   HOH A . 
D 4 HOH   253 1753 482  HOH   HOH A . 
D 4 HOH   254 1754 367  HOH   HOH A . 
D 4 HOH   255 1755 410  HOH   HOH A . 
D 4 HOH   256 1756 383  HOH   HOH A . 
D 4 HOH   257 1757 238  HOH   HOH A . 
D 4 HOH   258 1758 470  HOH   HOH A . 
E 4 HOH   1   1401 285  HOH   HOH B . 
E 4 HOH   2   1402 156  HOH   HOH B . 
E 4 HOH   3   1403 429  HOH   HOH B . 
E 4 HOH   4   1404 241  HOH   HOH B . 
E 4 HOH   5   1405 180  HOH   HOH B . 
E 4 HOH   6   1406 161  HOH   HOH B . 
E 4 HOH   7   1407 207  HOH   HOH B . 
E 4 HOH   8   1408 373  HOH   HOH B . 
E 4 HOH   9   1409 79   HOH   HOH B . 
E 4 HOH   10  1410 381  HOH   HOH B . 
E 4 HOH   11  1411 400  HOH   HOH B . 
E 4 HOH   12  1412 146  HOH   HOH B . 
E 4 HOH   13  1413 159  HOH   HOH B . 
E 4 HOH   14  1414 387  HOH   HOH B . 
E 4 HOH   15  1415 57   HOH   HOH B . 
E 4 HOH   16  1416 185  HOH   HOH B . 
E 4 HOH   17  1417 372  HOH   HOH B . 
E 4 HOH   18  1418 349  HOH   HOH B . 
E 4 HOH   19  1419 312  HOH   HOH B . 
E 4 HOH   20  1420 10   HOH   HOH B . 
E 4 HOH   21  1421 401  HOH   HOH B . 
E 4 HOH   22  1422 455  HOH   HOH B . 
E 4 HOH   23  1423 36   HOH   HOH B . 
E 4 HOH   24  1424 468  HOH   HOH B . 
E 4 HOH   25  1425 112  HOH   HOH B . 
E 4 HOH   26  1426 188  HOH   HOH B . 
E 4 HOH   27  1427 34   HOH   HOH B . 
E 4 HOH   28  1428 196  HOH   HOH B . 
E 4 HOH   29  1429 213  HOH   HOH B . 
E 4 HOH   30  1430 303  HOH   HOH B . 
E 4 HOH   31  1431 49   HOH   HOH B . 
E 4 HOH   32  1432 175  HOH   HOH B . 
E 4 HOH   33  1433 122  HOH   HOH B . 
E 4 HOH   34  1434 84   HOH   HOH B . 
E 4 HOH   35  1435 42   HOH   HOH B . 
E 4 HOH   36  1436 474  HOH   HOH B . 
E 4 HOH   37  1437 338  HOH   HOH B . 
E 4 HOH   38  1438 257  HOH   HOH B . 
E 4 HOH   39  1439 282  HOH   HOH B . 
E 4 HOH   40  1440 297  HOH   HOH B . 
E 4 HOH   41  1441 172  HOH   HOH B . 
E 4 HOH   42  1442 220  HOH   HOH B . 
E 4 HOH   43  1443 120  HOH   HOH B . 
E 4 HOH   44  1444 50   HOH   HOH B . 
E 4 HOH   45  1445 267  HOH   HOH B . 
E 4 HOH   46  1446 321  HOH   HOH B . 
E 4 HOH   47  1447 380  HOH   HOH B . 
E 4 HOH   48  1448 131  HOH   HOH B . 
E 4 HOH   49  1449 1    HOH   HOH B . 
E 4 HOH   50  1450 287  HOH   HOH B . 
E 4 HOH   51  1451 496  HOH   HOH B . 
E 4 HOH   52  1452 27   HOH   HOH B . 
E 4 HOH   53  1453 478  HOH   HOH B . 
E 4 HOH   54  1454 66   HOH   HOH B . 
E 4 HOH   55  1455 24   HOH   HOH B . 
E 4 HOH   56  1456 328  HOH   HOH B . 
E 4 HOH   57  1457 51   HOH   HOH B . 
E 4 HOH   58  1458 94   HOH   HOH B . 
E 4 HOH   59  1459 317  HOH   HOH B . 
E 4 HOH   60  1460 30   HOH   HOH B . 
E 4 HOH   61  1461 271  HOH   HOH B . 
E 4 HOH   62  1462 83   HOH   HOH B . 
E 4 HOH   63  1463 43   HOH   HOH B . 
E 4 HOH   64  1464 179  HOH   HOH B . 
E 4 HOH   65  1465 250  HOH   HOH B . 
E 4 HOH   66  1466 15   HOH   HOH B . 
E 4 HOH   67  1467 264  HOH   HOH B . 
E 4 HOH   68  1468 56   HOH   HOH B . 
E 4 HOH   69  1469 302  HOH   HOH B . 
E 4 HOH   70  1470 467  HOH   HOH B . 
E 4 HOH   71  1471 138  HOH   HOH B . 
E 4 HOH   72  1472 314  HOH   HOH B . 
E 4 HOH   73  1473 32   HOH   HOH B . 
E 4 HOH   74  1474 217  HOH   HOH B . 
E 4 HOH   75  1475 29   HOH   HOH B . 
E 4 HOH   76  1476 195  HOH   HOH B . 
E 4 HOH   77  1477 274  HOH   HOH B . 
E 4 HOH   78  1478 39   HOH   HOH B . 
E 4 HOH   79  1479 9    HOH   HOH B . 
E 4 HOH   80  1480 154  HOH   HOH B . 
E 4 HOH   81  1481 153  HOH   HOH B . 
E 4 HOH   82  1482 116  HOH   HOH B . 
E 4 HOH   83  1483 55   HOH   HOH B . 
E 4 HOH   84  1484 115  HOH   HOH B . 
E 4 HOH   85  1485 369  HOH   HOH B . 
E 4 HOH   86  1486 492  HOH   HOH B . 
E 4 HOH   87  1487 21   HOH   HOH B . 
E 4 HOH   88  1488 177  HOH   HOH B . 
E 4 HOH   89  1489 40   HOH   HOH B . 
E 4 HOH   90  1490 245  HOH   HOH B . 
E 4 HOH   91  1491 261  HOH   HOH B . 
E 4 HOH   92  1492 480  HOH   HOH B . 
E 4 HOH   93  1493 330  HOH   HOH B . 
E 4 HOH   94  1494 258  HOH   HOH B . 
E 4 HOH   95  1495 440  HOH   HOH B . 
E 4 HOH   96  1496 300  HOH   HOH B . 
E 4 HOH   97  1497 98   HOH   HOH B . 
E 4 HOH   98  1498 132  HOH   HOH B . 
E 4 HOH   99  1499 71   HOH   HOH B . 
E 4 HOH   100 1500 350  HOH   HOH B . 
E 4 HOH   101 1501 224  HOH   HOH B . 
E 4 HOH   102 1502 31   HOH   HOH B . 
E 4 HOH   103 1503 187  HOH   HOH B . 
E 4 HOH   104 1504 194  HOH   HOH B . 
E 4 HOH   105 1505 240  HOH   HOH B . 
E 4 HOH   106 1506 318  HOH   HOH B . 
E 4 HOH   107 1507 260  HOH   HOH B . 
E 4 HOH   108 1508 68   HOH   HOH B . 
E 4 HOH   109 1509 364  HOH   HOH B . 
E 4 HOH   110 1510 26   HOH   HOH B . 
E 4 HOH   111 1511 88   HOH   HOH B . 
E 4 HOH   112 1512 375  HOH   HOH B . 
E 4 HOH   113 1513 184  HOH   HOH B . 
E 4 HOH   114 1514 419  HOH   HOH B . 
E 4 HOH   115 1515 235  HOH   HOH B . 
E 4 HOH   116 1516 237  HOH   HOH B . 
E 4 HOH   117 1517 308  HOH   HOH B . 
E 4 HOH   118 1518 47   HOH   HOH B . 
E 4 HOH   119 1519 166  HOH   HOH B . 
E 4 HOH   120 1520 284  HOH   HOH B . 
E 4 HOH   121 1521 248  HOH   HOH B . 
E 4 HOH   122 1522 151  HOH   HOH B . 
E 4 HOH   123 1523 486  HOH   HOH B . 
E 4 HOH   124 1524 215  HOH   HOH B . 
E 4 HOH   125 1525 191  HOH   HOH B . 
E 4 HOH   126 1526 232  HOH   HOH B . 
E 4 HOH   127 1527 266  HOH   HOH B . 
E 4 HOH   128 1528 407  HOH   HOH B . 
E 4 HOH   129 1529 286  HOH   HOH B . 
E 4 HOH   130 1530 498  HOH   HOH B . 
E 4 HOH   131 1531 70   HOH   HOH B . 
E 4 HOH   132 1532 409  HOH   HOH B . 
E 4 HOH   133 1533 270  HOH   HOH B . 
E 4 HOH   134 1534 337  HOH   HOH B . 
E 4 HOH   135 1535 418  HOH   HOH B . 
E 4 HOH   136 1536 97   HOH   HOH B . 
E 4 HOH   137 1537 479  HOH   HOH B . 
E 4 HOH   138 1538 460  HOH   HOH B . 
E 4 HOH   139 1539 233  HOH   HOH B . 
E 4 HOH   140 1540 252  HOH   HOH B . 
E 4 HOH   141 1541 341  HOH   HOH B . 
E 4 HOH   142 1542 236  HOH   HOH B . 
E 4 HOH   143 1543 426  HOH   HOH B . 
E 4 HOH   144 1544 378  HOH   HOH B . 
E 4 HOH   145 1545 78   HOH   HOH B . 
E 4 HOH   146 1546 272  HOH   HOH B . 
E 4 HOH   147 1547 69   HOH   HOH B . 
E 4 HOH   148 1548 374  HOH   HOH B . 
E 4 HOH   149 1549 385  HOH   HOH B . 
E 4 HOH   150 1550 181  HOH   HOH B . 
E 4 HOH   151 1551 493  HOH   HOH B . 
E 4 HOH   152 1552 390  HOH   HOH B . 
E 4 HOH   153 1553 80   HOH   HOH B . 
E 4 HOH   154 1554 489  HOH   HOH B . 
E 4 HOH   155 1555 239  HOH   HOH B . 
E 4 HOH   156 1556 160  HOH   HOH B . 
E 4 HOH   157 1557 452  HOH   HOH B . 
E 4 HOH   158 1558 158  HOH   HOH B . 
E 4 HOH   159 1559 391  HOH   HOH B . 
E 4 HOH   160 1560 346  HOH   HOH B . 
E 4 HOH   161 1561 398  HOH   HOH B . 
E 4 HOH   162 1562 403  HOH   HOH B . 
E 4 HOH   163 1563 259  HOH   HOH B . 
E 4 HOH   164 1564 192  HOH   HOH B . 
E 4 HOH   165 1565 462  HOH   HOH B . 
E 4 HOH   166 1566 359  HOH   HOH B . 
E 4 HOH   167 1567 379  HOH   HOH B . 
E 4 HOH   168 1568 371  HOH   HOH B . 
E 4 HOH   169 1569 442  HOH   HOH B . 
E 4 HOH   170 1570 206  HOH   HOH B . 
E 4 HOH   171 1571 399  HOH   HOH B . 
E 4 HOH   172 1572 397  HOH   HOH B . 
E 4 HOH   173 1573 431  HOH   HOH B . 
E 4 HOH   174 1574 473  HOH   HOH B . 
E 4 HOH   175 1575 424  HOH   HOH B . 
E 4 HOH   176 1576 208  HOH   HOH B . 
E 4 HOH   177 1577 370  HOH   HOH B . 
E 4 HOH   178 1578 411  HOH   HOH B . 
E 4 HOH   179 1579 475  HOH   HOH B . 
E 4 HOH   180 1580 125  HOH   HOH B . 
E 4 HOH   181 1581 288  HOH   HOH B . 
E 4 HOH   182 1582 77   HOH   HOH B . 
E 4 HOH   183 1583 465  HOH   HOH B . 
E 4 HOH   184 1584 335  HOH   HOH B . 
E 4 HOH   185 1585 310  HOH   HOH B . 
E 4 HOH   186 1586 414  HOH   HOH B . 
E 4 HOH   187 1587 352  HOH   HOH B . 
E 4 HOH   188 1588 436  HOH   HOH B . 
E 4 HOH   189 1589 110  HOH   HOH B . 
E 4 HOH   190 1590 164  HOH   HOH B . 
E 4 HOH   191 1591 168  HOH   HOH B . 
E 4 HOH   192 1592 345  HOH   HOH B . 
E 4 HOH   193 1593 283  HOH   HOH B . 
E 4 HOH   194 1594 339  HOH   HOH B . 
E 4 HOH   195 1595 459  HOH   HOH B . 
E 4 HOH   196 1596 226  HOH   HOH B . 
E 4 HOH   197 1597 441  HOH   HOH B . 
E 4 HOH   198 1598 344  HOH   HOH B . 
E 4 HOH   199 1599 487  HOH   HOH B . 
E 4 HOH   200 1600 395  HOH   HOH B . 
E 4 HOH   201 1601 315  HOH   HOH B . 
E 4 HOH   202 1602 464  HOH   HOH B . 
E 4 HOH   203 1603 471  HOH   HOH B . 
E 4 HOH   204 1604 246  HOH   HOH B . 
E 4 HOH   205 1605 472  HOH   HOH B . 
E 4 HOH   206 1606 437  HOH   HOH B . 
E 4 HOH   207 1607 439  HOH   HOH B . 
E 4 HOH   208 1608 448  HOH   HOH B . 
E 4 HOH   209 1609 497  HOH   HOH B . 
E 4 HOH   210 1610 444  HOH   HOH B . 
E 4 HOH   211 1611 427  HOH   HOH B . 
E 4 HOH   212 1612 484  HOH   HOH B . 
E 4 HOH   213 1613 204  HOH   HOH B . 
E 4 HOH   214 1614 304  HOH   HOH B . 
E 4 HOH   215 1615 142  HOH   HOH B . 
E 4 HOH   216 1616 420  HOH   HOH B . 
E 4 HOH   217 1617 450  HOH   HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX    ? ? ? 1.21_5207 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS       ? ? ? .         2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? pointless ? ? ? .         3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER    ? ? ? .         4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9B9W 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     79.895 
_cell.length_a_esd                 ? 
_cell.length_b                     83.533 
_cell.length_b_esd                 ? 
_cell.length_c                     130.828 
_cell.length_c_esd                 ? 
_cell.volume                       873128.938 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9B9W 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9B9W 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.92 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          57.9 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '35% v/v tacsimate, pH 7.0' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            294 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-03-01 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.1808 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'CLSI BEAMLINE 08B1-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.1808 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   08B1-1 
_diffrn_source.pdbx_synchrotron_site       CLSI 
# 
_reflns.B_iso_Wilson_estimate                          28.11 
_reflns.entry_id                                       9B9W 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.92 
_reflns.d_resolution_low                               43.29 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     67507 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.98 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                2.0 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          15.04 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.04515 
_reflns.pdbx_Rpim_I_all                                0.03192 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       134923 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   1 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.03192 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.92 
_reflns_shell.d_res_low                                     1.95 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           5506 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2761 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.594 
_reflns_shell.pdbx_CC_star                                  0.863 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               31.07 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9B9W 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.92 
_refine.ls_d_res_low                             43.29 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     67500 
_refine.ls_number_reflns_R_free                  3397 
_refine.ls_number_reflns_R_work                  64103 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.98 
_refine.ls_percent_reflns_R_free                 5.03 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1725 
_refine.ls_R_factor_R_free                       0.1830 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1719 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 17.4417 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1778 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.92 
_refine_hist.d_res_low                        43.29 
_refine_hist.number_atoms_solvent             475 
_refine_hist.number_atoms_total               5315 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4747 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         93 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0066  ? 4904 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8529  ? 6663 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0581  ? 748  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0075  ? 847  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 12.9801 ? 1752 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.92 1.95  . 2761 139 2622 100.00 . . . . 0.2646 . . . . . . . . . . . 0.2593 
'X-RAY DIFFRACTION' 1.95 1.98  . .    135 2604 99.96  . . . . 0.2623 . . . . . . . . . . . 0.2869 
'X-RAY DIFFRACTION' 1.98 2.01  . .    158 2663 100.00 . . . . 0.2418 . . . . . . . . . . . 0.2602 
'X-RAY DIFFRACTION' 2.01 2.04  . .    115 2671 100.00 . . . . 0.2209 . . . . . . . . . . . 0.2470 
'X-RAY DIFFRACTION' 2.04 2.08  . .    141 2614 100.00 . . . . 0.2245 . . . . . . . . . . . 0.2594 
'X-RAY DIFFRACTION' 2.08 2.11  . .    144 2611 100.00 . . . . 0.2158 . . . . . . . . . . . 0.2638 
'X-RAY DIFFRACTION' 2.11 2.15  . .    138 2676 99.96  . . . . 0.2020 . . . . . . . . . . . 0.2217 
'X-RAY DIFFRACTION' 2.15 2.20  . .    152 2613 99.96  . . . . 0.1964 . . . . . . . . . . . 0.2078 
'X-RAY DIFFRACTION' 2.20 2.25  . .    140 2650 100.00 . . . . 0.1996 . . . . . . . . . . . 0.1823 
'X-RAY DIFFRACTION' 2.25 2.30  . .    141 2656 100.00 . . . . 0.1965 . . . . . . . . . . . 0.1966 
'X-RAY DIFFRACTION' 2.30 2.36  . .    133 2679 100.00 . . . . 0.1910 . . . . . . . . . . . 0.2114 
'X-RAY DIFFRACTION' 2.36 2.42  . .    131 2648 100.00 . . . . 0.1934 . . . . . . . . . . . 0.2250 
'X-RAY DIFFRACTION' 2.42 2.49  . .    143 2633 100.00 . . . . 0.1951 . . . . . . . . . . . 0.2207 
'X-RAY DIFFRACTION' 2.49 2.57  . .    143 2686 99.96  . . . . 0.1906 . . . . . . . . . . . 0.2196 
'X-RAY DIFFRACTION' 2.57 2.66  . .    142 2637 99.96  . . . . 0.1887 . . . . . . . . . . . 0.1845 
'X-RAY DIFFRACTION' 2.66 2.77  . .    149 2676 99.96  . . . . 0.1811 . . . . . . . . . . . 0.2020 
'X-RAY DIFFRACTION' 2.77 2.89  . .    134 2678 100.00 . . . . 0.1823 . . . . . . . . . . . 0.1768 
'X-RAY DIFFRACTION' 2.90 3.05  . .    135 2673 100.00 . . . . 0.1908 . . . . . . . . . . . 0.1876 
'X-RAY DIFFRACTION' 3.05 3.24  . .    139 2689 100.00 . . . . 0.1687 . . . . . . . . . . . 0.1943 
'X-RAY DIFFRACTION' 3.24 3.49  . .    128 2719 99.93  . . . . 0.1483 . . . . . . . . . . . 0.1581 
'X-RAY DIFFRACTION' 3.49 3.84  . .    132 2696 100.00 . . . . 0.1461 . . . . . . . . . . . 0.1458 
'X-RAY DIFFRACTION' 3.84 4.39  . .    167 2702 99.93  . . . . 0.1304 . . . . . . . . . . . 0.1458 
'X-RAY DIFFRACTION' 4.39 5.53  . .    158 2738 99.97  . . . . 0.1322 . . . . . . . . . . . 0.1392 
'X-RAY DIFFRACTION' 5.54 43.29 . .    160 2869 99.87  . . . . 0.1692 . . . . . . . . . . . 0.1790 
# 
_struct.entry_id                     9B9W 
_struct.title                        'Crystal structure of the ternary complex of DCAF1 and WDR5 with PROTAC, OICR-40792' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9B9W 
_struct_keywords.text            'E3 ligase, adaptor, PROTAC, WDR, ternary complex, PROTEIN BINDING' 
_struct_keywords.pdbx_keywords   'PROTEIN BINDING' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP WDR5_HUMAN  P61964 ? 1 
;TQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV
SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDG
SLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIF
ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
;
24   
2 UNP DCAF1_HUMAN Q9Y4B6 ? 2 
;FRPISVFREANEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSATWSQP
LSALWGMKSVFDMKHSFTEDHYVEFSKHSQDRVIGTKGDIAHIYDIQTGNKLLTLFNPDLANNYKRNCATFNPTDDLVLN
DGVLWDVRSAQAIHKFDKFNMNISGVFHPNGLEVIINTEIWDLRTFHLLHTVPALDQCRVVFNHTGTVMYGAMLQADDED
DLMEERMKSPFGSSFRTFNATDYKPIATIDVKRNIFDLCTDTKDCYLAVIENQGSMDALNMDTVCRLYEVG
;
1080 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9B9W A 19 ? 329 ? P61964 24   ? 334  ? 24   334  
2 2 9B9W B 28 ? 338 ? Q9Y4B6 1080 ? 1390 ? 1080 1390 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9B9W MET A 1  ? UNP P61964 ? ? 'initiating methionine' 6    1  
1 9B9W HIS A 2  ? UNP P61964 ? ? 'expression tag'        7    2  
1 9B9W HIS A 3  ? UNP P61964 ? ? 'expression tag'        8    3  
1 9B9W HIS A 4  ? UNP P61964 ? ? 'expression tag'        9    4  
1 9B9W HIS A 5  ? UNP P61964 ? ? 'expression tag'        10   5  
1 9B9W HIS A 6  ? UNP P61964 ? ? 'expression tag'        11   6  
1 9B9W HIS A 7  ? UNP P61964 ? ? 'expression tag'        12   7  
1 9B9W SER A 8  ? UNP P61964 ? ? 'expression tag'        13   8  
1 9B9W SER A 9  ? UNP P61964 ? ? 'expression tag'        14   9  
1 9B9W GLY A 10 ? UNP P61964 ? ? 'expression tag'        15   10 
1 9B9W ARG A 11 ? UNP P61964 ? ? 'expression tag'        16   11 
1 9B9W GLU A 12 ? UNP P61964 ? ? 'expression tag'        17   12 
1 9B9W ASN A 13 ? UNP P61964 ? ? 'expression tag'        18   13 
1 9B9W LEU A 14 ? UNP P61964 ? ? 'expression tag'        19   14 
1 9B9W TYR A 15 ? UNP P61964 ? ? 'expression tag'        20   15 
1 9B9W PHE A 16 ? UNP P61964 ? ? 'expression tag'        21   16 
1 9B9W GLN A 17 ? UNP P61964 ? ? 'expression tag'        22   17 
1 9B9W GLY A 18 ? UNP P61964 ? ? 'expression tag'        23   18 
2 9B9W MET B 1  ? UNP Q9Y4B6 ? ? 'initiating methionine' 1053 19 
2 9B9W GLY B 2  ? UNP Q9Y4B6 ? ? 'expression tag'        1054 20 
2 9B9W SER B 3  ? UNP Q9Y4B6 ? ? 'expression tag'        1055 21 
2 9B9W SER B 4  ? UNP Q9Y4B6 ? ? 'expression tag'        1056 22 
2 9B9W HIS B 5  ? UNP Q9Y4B6 ? ? 'expression tag'        1057 23 
2 9B9W HIS B 6  ? UNP Q9Y4B6 ? ? 'expression tag'        1058 24 
2 9B9W HIS B 7  ? UNP Q9Y4B6 ? ? 'expression tag'        1059 25 
2 9B9W HIS B 8  ? UNP Q9Y4B6 ? ? 'expression tag'        1060 26 
2 9B9W HIS B 9  ? UNP Q9Y4B6 ? ? 'expression tag'        1061 27 
2 9B9W HIS B 10 ? UNP Q9Y4B6 ? ? 'expression tag'        1062 28 
2 9B9W SER B 11 ? UNP Q9Y4B6 ? ? 'expression tag'        1063 29 
2 9B9W SER B 12 ? UNP Q9Y4B6 ? ? 'expression tag'        1064 30 
2 9B9W GLY B 13 ? UNP Q9Y4B6 ? ? 'expression tag'        1065 31 
2 9B9W ARG B 14 ? UNP Q9Y4B6 ? ? 'expression tag'        1066 32 
2 9B9W GLU B 15 ? UNP Q9Y4B6 ? ? 'expression tag'        1067 33 
2 9B9W ASN B 16 ? UNP Q9Y4B6 ? ? 'expression tag'        1068 34 
2 9B9W LEU B 17 ? UNP Q9Y4B6 ? ? 'expression tag'        1069 35 
2 9B9W TYR B 18 ? UNP Q9Y4B6 ? ? 'expression tag'        1070 36 
2 9B9W PHE B 19 ? UNP Q9Y4B6 ? ? 'expression tag'        1071 37 
2 9B9W GLN B 20 ? UNP Q9Y4B6 ? ? 'expression tag'        1072 38 
2 9B9W GLY B 21 ? UNP Q9Y4B6 ? ? 'expression tag'        1073 39 
2 9B9W SER B 22 ? UNP Q9Y4B6 ? ? 'expression tag'        1074 40 
2 9B9W SER B 23 ? UNP Q9Y4B6 ? ? 'expression tag'        1075 41 
2 9B9W ARG B 24 ? UNP Q9Y4B6 ? ? 'expression tag'        1076 42 
2 9B9W ALA B 25 ? UNP Q9Y4B6 ? ? 'expression tag'        1077 43 
2 9B9W SER B 26 ? UNP Q9Y4B6 ? ? 'expression tag'        1078 44 
2 9B9W ALA B 27 ? UNP Q9Y4B6 ? ? 'expression tag'        1079 45 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
_struct_conf.conf_type_id            HELX_P 
_struct_conf.id                      HELX_P1 
_struct_conf.pdbx_PDB_helix_id       AA1 
_struct_conf.beg_label_comp_id       PRO 
_struct_conf.beg_label_asym_id       B 
_struct_conf.beg_label_seq_id        240 
_struct_conf.pdbx_beg_PDB_ins_code   ? 
_struct_conf.end_label_comp_id       ASP 
_struct_conf.end_label_asym_id       B 
_struct_conf.end_label_seq_id        243 
_struct_conf.pdbx_end_PDB_ins_code   ? 
_struct_conf.beg_auth_comp_id        PRO 
_struct_conf.beg_auth_asym_id        B 
_struct_conf.beg_auth_seq_id         1292 
_struct_conf.end_auth_comp_id        ASP 
_struct_conf.end_auth_asym_id        B 
_struct_conf.end_auth_seq_id         1295 
_struct_conf.pdbx_PDB_helix_class    5 
_struct_conf.details                 ? 
_struct_conf.pdbx_PDB_helix_length   4 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          GLN 
_struct_mon_prot_cis.label_seq_id           106 
_struct_mon_prot_cis.label_asym_id          B 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           GLN 
_struct_mon_prot_cis.auth_seq_id            1158 
_struct_mon_prot_cis.auth_asym_id           B 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    107 
_struct_mon_prot_cis.pdbx_label_asym_id_2   B 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     1159 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    B 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       0.67 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 4 ? 
AA3 ? 4 ? 
AA4 ? 4 ? 
AA5 ? 4 ? 
AA6 ? 4 ? 
AA7 ? 4 ? 
AA8 ? 4 ? 
AA9 ? 4 ? 
AB1 ? 4 ? 
AB2 ? 4 ? 
AB3 ? 4 ? 
AB4 ? 4 ? 
AB5 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
AA8 3 4 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AA9 2 3 ? anti-parallel 
AA9 3 4 ? anti-parallel 
AB1 1 2 ? anti-parallel 
AB1 2 3 ? anti-parallel 
AB1 3 4 ? anti-parallel 
AB2 1 2 ? anti-parallel 
AB2 2 3 ? anti-parallel 
AB2 3 4 ? anti-parallel 
AB3 1 2 ? anti-parallel 
AB3 2 3 ? anti-parallel 
AB3 3 4 ? anti-parallel 
AB4 1 2 ? anti-parallel 
AB4 2 3 ? anti-parallel 
AB4 3 4 ? anti-parallel 
AB5 1 2 ? anti-parallel 
AB5 2 3 ? anti-parallel 
AB5 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 31  ? LEU A 36  ? ALA A 36   LEU A 41   
AA1 2 ILE A 322 ? LYS A 326 ? ILE A 327  LYS A 331  
AA1 3 ILE A 310 ? ALA A 315 ? ILE A 315  ALA A 320  
AA1 4 VAL A 299 ? CYS A 304 ? VAL A 304  CYS A 309  
AA2 1 VAL A 43  ? PHE A 48  ? VAL A 48   PHE A 53   
AA2 2 TRP A 54  ? SER A 59  ? TRP A 59   SER A 64   
AA2 3 LEU A 63  ? GLY A 68  ? LEU A 68   GLY A 73   
AA2 4 PHE A 74  ? SER A 79  ? PHE A 79   SER A 84   
AA3 1 ILE A 85  ? TRP A 90  ? ILE A 90   TRP A 95   
AA3 2 LEU A 96  ? SER A 101 ? LEU A 101  SER A 106  
AA3 3 THR A 105 ? ASP A 110 ? THR A 110  ASP A 115  
AA3 4 LYS A 115 ? LYS A 121 ? LYS A 120  LYS A 126  
AA4 1 VAL A 127 ? PHE A 132 ? VAL A 132  PHE A 137  
AA4 2 LEU A 138 ? SER A 143 ? LEU A 143  SER A 148  
AA4 3 VAL A 148 ? ASP A 152 ? VAL A 153  ASP A 157  
AA4 4 CYS A 158 ? LEU A 162 ? CYS A 163  LEU A 167  
AA5 1 VAL A 169 ? PHE A 174 ? VAL A 174  PHE A 179  
AA5 2 LEU A 180 ? SER A 185 ? LEU A 185  SER A 190  
AA5 3 CYS A 190 ? ASP A 194 ? CYS A 195  ASP A 199  
AA5 4 CYS A 200 ? LEU A 204 ? CYS A 205  LEU A 209  
AA6 1 VAL A 212 ? PHE A 217 ? VAL A 217  PHE A 222  
AA6 2 TYR A 223 ? THR A 228 ? TYR A 228  THR A 233  
AA6 3 THR A 232 ? ASP A 237 ? THR A 237  ASP A 242  
AA6 4 LYS A 242 ? TYR A 247 ? LYS A 247  TYR A 252  
AA7 1 ALA A 259 ? SER A 262 ? ALA A 264  SER A 267  
AA7 2 TRP A 268 ? SER A 271 ? TRP A 273  SER A 276  
AA7 3 VAL A 278 ? ASN A 282 ? VAL A 283  ASN A 287  
AA7 4 ILE A 288 ? LEU A 292 ? ILE A 293  LEU A 297  
AA8 1 ARG B 29  ? ARG B 35  ? ARG B 1081 ARG B 1087 
AA8 2 THR B 330 ? GLU B 336 ? THR B 1382 GLU B 1388 
AA8 3 TYR B 313 ? ASN B 319 ? TYR B 1365 ASN B 1371 
AA8 4 ASN B 301 ? THR B 307 ? ASN B 1353 THR B 1359 
AA9 1 PHE B 44  ? PHE B 49  ? PHE B 1096 PHE B 1101 
AA9 2 PHE B 55  ? THR B 60  ? PHE B 1107 THR B 1112 
AA9 3 GLN B 64  ? ASN B 69  ? GLN B 1116 ASN B 1121 
AA9 4 GLU B 75  ? ASN B 80  ? GLU B 1127 ASN B 1132 
AB1 1 ILE B 86  ? PRO B 91  ? ILE B 1138 PRO B 1143 
AB1 2 LEU B 97  ? ALA B 102 ? LEU B 1149 ALA B 1154 
AB1 3 SER B 109 ? GLY B 113 ? SER B 1161 GLY B 1165 
AB1 4 ASP B 119 ? PHE B 124 ? ASP B 1171 PHE B 1176 
AB2 1 TYR B 129 ? PHE B 132 ? TYR B 1181 PHE B 1184 
AB2 2 ARG B 139 ? LYS B 144 ? ARG B 1191 LYS B 1196 
AB2 3 ILE B 147 ? ASP B 152 ? ILE B 1199 ASP B 1204 
AB2 4 LYS B 158 ? LEU B 162 ? LYS B 1210 LEU B 1214 
AB3 1 THR B 177 ? PHE B 178 ? THR B 1229 PHE B 1230 
AB3 2 LEU B 184 ? ASN B 187 ? LEU B 1236 ASN B 1239 
AB3 3 VAL B 190 ? ASP B 193 ? VAL B 1242 ASP B 1245 
AB3 4 GLN B 198 ? LYS B 202 ? GLN B 1250 LYS B 1254 
AB4 1 VAL B 213 ? PHE B 214 ? VAL B 1265 PHE B 1266 
AB4 2 GLU B 220 ? ILE B 223 ? GLU B 1272 ILE B 1275 
AB4 3 GLU B 226 ? ASP B 229 ? GLU B 1278 ASP B 1281 
AB4 4 LEU B 235 ? THR B 238 ? LEU B 1287 THR B 1290 
AB5 1 CYS B 245 ? PHE B 249 ? CYS B 1297 PHE B 1301 
AB5 2 VAL B 255 ? LEU B 261 ? VAL B 1307 LEU B 1313 
AB5 3 PHE B 278 ? ASN B 286 ? PHE B 1330 ASN B 1338 
AB5 4 PRO B 292 ? ASP B 297 ? PRO B 1344 ASP B 1349 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N LEU A 36  ? N LEU A 41   O ILE A 322 ? O ILE A 327  
AA1 2 3 O TRP A 325 ? O TRP A 330  N ILE A 311 ? N ILE A 316  
AA1 3 4 O ALA A 312 ? O ALA A 317  N ALA A 303 ? N ALA A 308  
AA2 1 2 N LYS A 47  ? N LYS A 52   O ALA A 56  ? O ALA A 61   
AA2 2 3 N LEU A 55  ? N LEU A 60   O TRP A 67  ? O TRP A 72   
AA2 3 4 N ILE A 64  ? N ILE A 69   O ILE A 78  ? O ILE A 83   
AA3 1 2 N SER A 86  ? N SER A 91   O ALA A 100 ? O ALA A 105  
AA3 2 3 N LEU A 97  ? N LEU A 102  O TRP A 109 ? O TRP A 114  
AA3 3 4 N LEU A 106 ? N LEU A 111  O LEU A 120 ? O LEU A 125  
AA4 1 2 N ASN A 131 ? N ASN A 136  O VAL A 140 ? O VAL A 145  
AA4 2 3 N ILE A 139 ? N ILE A 144  O TRP A 151 ? O TRP A 156  
AA4 3 4 N VAL A 148 ? N VAL A 153  O LEU A 162 ? O LEU A 167  
AA5 1 2 N HIS A 173 ? N HIS A 178  O VAL A 182 ? O VAL A 187  
AA5 2 3 N ILE A 181 ? N ILE A 186  O TRP A 193 ? O TRP A 198  
AA5 3 4 N ILE A 192 ? N ILE A 197  O LEU A 201 ? O LEU A 206  
AA6 1 2 N LYS A 216 ? N LYS A 221  O LEU A 225 ? O LEU A 230  
AA6 2 3 N ILE A 224 ? N ILE A 229  O TRP A 236 ? O TRP A 241  
AA6 3 4 N ASP A 237 ? N ASP A 242  O LYS A 242 ? O LYS A 247  
AA7 1 2 N SER A 262 ? N SER A 267  O TRP A 268 ? O TRP A 273  
AA7 2 3 N SER A 271 ? N SER A 276  O TYR A 279 ? O TYR A 284  
AA7 3 4 N VAL A 278 ? N VAL A 283  O LEU A 292 ? O LEU A 297  
AA8 1 2 N ILE B 31  ? N ILE B 1083 O LEU B 334 ? O LEU B 1386 
AA8 2 3 O VAL B 331 ? O VAL B 1383 N GLU B 318 ? N GLU B 1370 
AA8 3 4 O ALA B 315 ? O ALA B 1367 N CYS B 306 ? N CYS B 1358 
AA9 1 2 N ALA B 48  ? N ALA B 1100 O MET B 57  ? O MET B 1109 
AA9 2 3 N LEU B 58  ? N LEU B 1110 O LYS B 66  ? O LYS B 1118 
AA9 3 4 N LEU B 67  ? N LEU B 1119 O GLU B 76  ? O GLU B 1128 
AB1 1 2 N THR B 87  ? N THR B 1139 O SER B 101 ? O SER B 1153 
AB1 2 3 N LEU B 98  ? N LEU B 1150 O TRP B 112 ? O TRP B 1164 
AB1 3 4 N LEU B 111 ? N LEU B 1163 O LYS B 121 ? O LYS B 1173 
AB2 1 2 N GLU B 131 ? N GLU B 1183 O ILE B 141 ? O ILE B 1193 
AB2 2 3 N GLY B 142 ? N GLY B 1194 O HIS B 149 ? O HIS B 1201 
AB2 3 4 N ILE B 150 ? N ILE B 1202 O LEU B 159 ? O LEU B 1211 
AB3 1 2 N THR B 177 ? N THR B 1229 O LEU B 186 ? O LEU B 1238 
AB3 2 3 N VAL B 185 ? N VAL B 1237 O TRP B 192 ? O TRP B 1244 
AB3 3 4 N LEU B 191 ? N LEU B 1243 O HIS B 201 ? O HIS B 1253 
AB4 1 2 N VAL B 213 ? N VAL B 1265 O ILE B 222 ? O ILE B 1274 
AB4 2 3 N ILE B 223 ? N ILE B 1275 O GLU B 226 ? O GLU B 1278 
AB4 3 4 N ILE B 227 ? N ILE B 1279 O LEU B 236 ? O LEU B 1288 
AB5 1 2 N VAL B 248 ? N VAL B 1300 O TYR B 257 ? O TYR B 1309 
AB5 2 3 N GLY B 258 ? N GLY B 1310 O ARG B 283 ? O ARG B 1335 
AB5 3 4 N PHE B 282 ? N PHE B 1334 O ILE B 296 ? O ILE B 1348 
# 
_pdbx_entry_details.entry_id                   9B9W 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 O A HOH 1542 ? ? O A HOH 1564 ? ? 1.89 
2  1 O A HOH 1570 ? ? O A HOH 1706 ? ? 1.93 
3  1 O A HOH 1542 ? ? O A HOH 1750 ? ? 1.97 
4  1 O B HOH 1450 ? ? O B HOH 1594 ? ? 2.03 
5  1 O B HOH 1482 ? ? O B HOH 1549 ? ? 2.05 
6  1 O A HOH 1528 ? ? O A HOH 1723 ? ? 2.11 
7  1 O B HOH 1554 ? ? O B HOH 1577 ? ? 2.11 
8  1 O B HOH 1425 ? ? O B HOH 1526 ? ? 2.16 
9  1 O A HOH 1622 ? ? O A HOH 1716 ? ? 2.16 
10 1 O B HOH 1507 ? ? O B HOH 1598 ? ? 2.17 
11 1 O A HOH 1572 ? ? O A HOH 1655 ? ? 2.19 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASP A 211  ? ? -97.69  -143.97 
2  1 LEU A 234  ? ? -78.13  36.78   
3  1 ASP A 324  ? ? -127.19 -59.39  
4  1 ASN B 1090 ? ? 76.59   -14.90  
5  1 ARG B 1106 ? ? 85.87   -7.45   
6  1 THR B 1155 ? B -91.74  -60.58  
7  1 SER B 1168 ? ? 50.75   -103.37 
8  1 HIS B 1187 ? ? -75.27  -74.20  
9  1 ASN B 1276 ? ? 59.42   -123.13 
10 1 ALA B 1315 ? ? -72.33  -136.73 
11 1 TYR B 1342 ? ? 59.59   15.74   
12 1 ILE B 1345 ? ? -109.72 -64.03  
13 1 ASP B 1376 ? ? 57.66   -126.93 
14 1 ASN B 1379 ? ? -104.30 71.86   
15 1 ASP B 1381 ? ? -153.45 81.84   
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       1758 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   7.40 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 6    ? A MET 1   
2  1 Y 1 A HIS 7    ? A HIS 2   
3  1 Y 1 A HIS 8    ? A HIS 3   
4  1 Y 1 A HIS 9    ? A HIS 4   
5  1 Y 1 A HIS 10   ? A HIS 5   
6  1 Y 1 A HIS 11   ? A HIS 6   
7  1 Y 1 A HIS 12   ? A HIS 7   
8  1 Y 1 A SER 13   ? A SER 8   
9  1 Y 1 A SER 14   ? A SER 9   
10 1 Y 1 A GLY 15   ? A GLY 10  
11 1 Y 1 A ARG 16   ? A ARG 11  
12 1 Y 1 A GLU 17   ? A GLU 12  
13 1 Y 1 A ASN 18   ? A ASN 13  
14 1 Y 1 A LEU 19   ? A LEU 14  
15 1 Y 1 A TYR 20   ? A TYR 15  
16 1 Y 1 A PHE 21   ? A PHE 16  
17 1 Y 1 A GLN 22   ? A GLN 17  
18 1 Y 1 A GLY 23   ? A GLY 18  
19 1 Y 1 A THR 24   ? A THR 19  
20 1 Y 1 A GLN 25   ? A GLN 20  
21 1 Y 1 A SER 26   ? A SER 21  
22 1 Y 1 A LYS 27   ? A LYS 22  
23 1 Y 1 A PRO 28   ? A PRO 23  
24 1 Y 1 A THR 29   ? A THR 24  
25 1 Y 1 A PRO 30   ? A PRO 25  
26 1 Y 1 B MET 1053 ? B MET 1   
27 1 Y 1 B GLY 1054 ? B GLY 2   
28 1 Y 1 B SER 1055 ? B SER 3   
29 1 Y 1 B SER 1056 ? B SER 4   
30 1 Y 1 B HIS 1057 ? B HIS 5   
31 1 Y 1 B HIS 1058 ? B HIS 6   
32 1 Y 1 B HIS 1059 ? B HIS 7   
33 1 Y 1 B HIS 1060 ? B HIS 8   
34 1 Y 1 B HIS 1061 ? B HIS 9   
35 1 Y 1 B HIS 1062 ? B HIS 10  
36 1 Y 1 B SER 1063 ? B SER 11  
37 1 Y 1 B SER 1064 ? B SER 12  
38 1 Y 1 B GLY 1065 ? B GLY 13  
39 1 Y 1 B ARG 1066 ? B ARG 14  
40 1 Y 1 B GLU 1067 ? B GLU 15  
41 1 Y 1 B ASN 1068 ? B ASN 16  
42 1 Y 1 B LEU 1069 ? B LEU 17  
43 1 Y 1 B TYR 1070 ? B TYR 18  
44 1 Y 1 B PHE 1071 ? B PHE 19  
45 1 Y 1 B GLN 1072 ? B GLN 20  
46 1 Y 1 B GLY 1073 ? B GLY 21  
47 1 Y 1 B SER 1074 ? B SER 22  
48 1 Y 1 B SER 1075 ? B SER 23  
49 1 Y 1 B ARG 1076 ? B ARG 24  
50 1 Y 1 B ALA 1077 ? B ALA 25  
51 1 Y 1 B SER 1078 ? B SER 26  
52 1 Y 1 B ALA 1079 ? B ALA 27  
53 1 Y 1 B ASP 1317 ? B ASP 265 
54 1 Y 1 B GLU 1318 ? B GLU 266 
55 1 Y 1 B ASP 1319 ? B ASP 267 
56 1 Y 1 B ASP 1320 ? B ASP 268 
57 1 Y 1 B LEU 1321 ? B LEU 269 
58 1 Y 1 B MET 1322 ? B MET 270 
59 1 Y 1 B GLU 1323 ? B GLU 271 
60 1 Y 1 B GLU 1324 ? B GLU 272 
61 1 Y 1 B ARG 1325 ? B ARG 273 
62 1 Y 1 B MET 1326 ? B MET 274 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1ANN C18  C  N N 1   
A1ANN C19  C  N N 2   
A1ANN C21  C  N N 3   
A1ANN C22  C  N N 4   
A1ANN C01  C  N N 5   
A1ANN C03  C  N N 6   
A1ANN C04  C  N N 7   
A1ANN C06  C  N N 8   
A1ANN C07  C  N N 9   
A1ANN C09  C  N N 10  
A1ANN C10  C  N N 11  
A1ANN C12  C  N N 12  
A1ANN C13  C  N N 13  
A1ANN C15  C  N N 14  
A1ANN C16  C  N N 15  
A1ANN C24  C  N N 16  
A1ANN C26  C  Y N 17  
A1ANN C27  C  Y N 18  
A1ANN C28  C  Y N 19  
A1ANN C29  C  Y N 20  
A1ANN C31  C  Y N 21  
A1ANN C32  C  Y N 22  
A1ANN C33  C  Y N 23  
A1ANN C34  C  Y N 24  
A1ANN C35  C  Y N 25  
A1ANN C37  C  N N 26  
A1ANN C39  C  Y N 27  
A1ANN C40  C  Y N 28  
A1ANN C41  C  Y N 29  
A1ANN C42  C  Y N 30  
A1ANN C44  C  Y N 31  
A1ANN C45  C  Y N 32  
A1ANN C46  C  N N 33  
A1ANN C50  C  Y N 34  
A1ANN C52  C  N N 35  
A1ANN C53  C  N S 36  
A1ANN C54  C  N N 37  
A1ANN C56  C  N N 38  
A1ANN C57  C  N R 39  
A1ANN C58  C  N N 40  
A1ANN C59  C  N N 41  
A1ANN C60  C  Y N 42  
A1ANN C61  C  Y N 43  
A1ANN C63  C  N N 44  
A1ANN C64  C  N N 45  
A1ANN C65  C  Y N 46  
A1ANN C67  C  Y N 47  
A1ANN C68  C  Y N 48  
A1ANN C69  C  N N 49  
A1ANN C72  C  N S 50  
A1ANN C73  C  Y N 51  
A1ANN C74  C  Y N 52  
A1ANN C75  C  Y N 53  
A1ANN C77  C  Y N 54  
A1ANN C79  C  Y N 55  
A1ANN C80  C  Y N 56  
A1ANN C81  C  N N 57  
A1ANN C82  C  N N 58  
A1ANN C85  C  Y N 59  
A1ANN C86  C  Y N 60  
A1ANN C87  C  Y N 61  
A1ANN C88  C  Y N 62  
A1ANN C89  C  Y N 63  
A1ANN C91  C  Y N 64  
A1ANN C92  C  Y N 65  
A1ANN F30  F  N N 66  
A1ANN F43  F  N N 67  
A1ANN F47  F  N N 68  
A1ANN F48  F  N N 69  
A1ANN F49  F  N N 70  
A1ANN F78  F  N N 71  
A1ANN F93  F  N N 72  
A1ANN N02  N  N N 73  
A1ANN N23  N  N N 74  
A1ANN N36  N  N N 75  
A1ANN N51  N  N N 76  
A1ANN N55  N  N N 77  
A1ANN N66  N  Y N 78  
A1ANN N71  N  N N 79  
A1ANN N84  N  N N 80  
A1ANN O05  O  N N 81  
A1ANN O08  O  N N 82  
A1ANN O11  O  N N 83  
A1ANN O14  O  N N 84  
A1ANN O17  O  N N 85  
A1ANN O20  O  N N 86  
A1ANN O25  O  N N 87  
A1ANN O38  O  N N 88  
A1ANN O62  O  N N 89  
A1ANN O70  O  N N 90  
A1ANN O83  O  N N 91  
A1ANN CL76 CL N N 92  
A1ANN CL90 CL N N 93  
A1ANN H181 H  N N 94  
A1ANN H182 H  N N 95  
A1ANN H192 H  N N 96  
A1ANN H191 H  N N 97  
A1ANN H211 H  N N 98  
A1ANN H212 H  N N 99  
A1ANN H221 H  N N 100 
A1ANN H222 H  N N 101 
A1ANN H032 H  N N 102 
A1ANN H031 H  N N 103 
A1ANN H042 H  N N 104 
A1ANN H041 H  N N 105 
A1ANN H062 H  N N 106 
A1ANN H061 H  N N 107 
A1ANN H072 H  N N 108 
A1ANN H071 H  N N 109 
A1ANN H091 H  N N 110 
A1ANN H092 H  N N 111 
A1ANN H102 H  N N 112 
A1ANN H101 H  N N 113 
A1ANN H122 H  N N 114 
A1ANN H121 H  N N 115 
A1ANN H132 H  N N 116 
A1ANN H131 H  N N 117 
A1ANN H151 H  N N 118 
A1ANN H152 H  N N 119 
A1ANN H161 H  N N 120 
A1ANN H162 H  N N 121 
A1ANN H271 H  N N 122 
A1ANN H281 H  N N 123 
A1ANN H331 H  N N 124 
A1ANN H341 H  N N 125 
A1ANN H411 H  N N 126 
A1ANN H441 H  N N 127 
A1ANN H451 H  N N 128 
A1ANN H522 H  N N 129 
A1ANN H521 H  N N 130 
A1ANN H531 H  N N 131 
A1ANN H541 H  N N 132 
A1ANN H542 H  N N 133 
A1ANN H543 H  N N 134 
A1ANN H562 H  N N 135 
A1ANN H561 H  N N 136 
A1ANN H563 H  N N 137 
A1ANN H571 H  N N 138 
A1ANN H581 H  N N 139 
A1ANN H582 H  N N 140 
A1ANN H583 H  N N 141 
A1ANN H592 H  N N 142 
A1ANN H591 H  N N 143 
A1ANN H601 H  N N 144 
A1ANN H611 H  N N 145 
A1ANN H631 H  N N 146 
A1ANN H641 H  N N 147 
A1ANN H671 H  N N 148 
A1ANN H721 H  N N 149 
A1ANN H741 H  N N 150 
A1ANN H791 H  N N 151 
A1ANN H801 H  N N 152 
A1ANN H812 H  N N 153 
A1ANN H811 H  N N 154 
A1ANN H871 H  N N 155 
A1ANN H881 H  N N 156 
A1ANN H911 H  N N 157 
A1ANN H021 H  N N 158 
A1ANN H231 H  N N 159 
A1ANN H361 H  N N 160 
A1ANN H661 H  N N 161 
A1ANN H711 H  N N 162 
A1ANN H841 H  N N 163 
A1ANN H842 H  N N 164 
ALA   N    N  N N 165 
ALA   CA   C  N S 166 
ALA   C    C  N N 167 
ALA   O    O  N N 168 
ALA   CB   C  N N 169 
ALA   OXT  O  N N 170 
ALA   H    H  N N 171 
ALA   H2   H  N N 172 
ALA   HA   H  N N 173 
ALA   HB1  H  N N 174 
ALA   HB2  H  N N 175 
ALA   HB3  H  N N 176 
ALA   HXT  H  N N 177 
ARG   N    N  N N 178 
ARG   CA   C  N S 179 
ARG   C    C  N N 180 
ARG   O    O  N N 181 
ARG   CB   C  N N 182 
ARG   CG   C  N N 183 
ARG   CD   C  N N 184 
ARG   NE   N  N N 185 
ARG   CZ   C  N N 186 
ARG   NH1  N  N N 187 
ARG   NH2  N  N N 188 
ARG   OXT  O  N N 189 
ARG   H    H  N N 190 
ARG   H2   H  N N 191 
ARG   HA   H  N N 192 
ARG   HB2  H  N N 193 
ARG   HB3  H  N N 194 
ARG   HG2  H  N N 195 
ARG   HG3  H  N N 196 
ARG   HD2  H  N N 197 
ARG   HD3  H  N N 198 
ARG   HE   H  N N 199 
ARG   HH11 H  N N 200 
ARG   HH12 H  N N 201 
ARG   HH21 H  N N 202 
ARG   HH22 H  N N 203 
ARG   HXT  H  N N 204 
ASN   N    N  N N 205 
ASN   CA   C  N S 206 
ASN   C    C  N N 207 
ASN   O    O  N N 208 
ASN   CB   C  N N 209 
ASN   CG   C  N N 210 
ASN   OD1  O  N N 211 
ASN   ND2  N  N N 212 
ASN   OXT  O  N N 213 
ASN   H    H  N N 214 
ASN   H2   H  N N 215 
ASN   HA   H  N N 216 
ASN   HB2  H  N N 217 
ASN   HB3  H  N N 218 
ASN   HD21 H  N N 219 
ASN   HD22 H  N N 220 
ASN   HXT  H  N N 221 
ASP   N    N  N N 222 
ASP   CA   C  N S 223 
ASP   C    C  N N 224 
ASP   O    O  N N 225 
ASP   CB   C  N N 226 
ASP   CG   C  N N 227 
ASP   OD1  O  N N 228 
ASP   OD2  O  N N 229 
ASP   OXT  O  N N 230 
ASP   H    H  N N 231 
ASP   H2   H  N N 232 
ASP   HA   H  N N 233 
ASP   HB2  H  N N 234 
ASP   HB3  H  N N 235 
ASP   HD2  H  N N 236 
ASP   HXT  H  N N 237 
CYS   N    N  N N 238 
CYS   CA   C  N R 239 
CYS   C    C  N N 240 
CYS   O    O  N N 241 
CYS   CB   C  N N 242 
CYS   SG   S  N N 243 
CYS   OXT  O  N N 244 
CYS   H    H  N N 245 
CYS   H2   H  N N 246 
CYS   HA   H  N N 247 
CYS   HB2  H  N N 248 
CYS   HB3  H  N N 249 
CYS   HG   H  N N 250 
CYS   HXT  H  N N 251 
GLN   N    N  N N 252 
GLN   CA   C  N S 253 
GLN   C    C  N N 254 
GLN   O    O  N N 255 
GLN   CB   C  N N 256 
GLN   CG   C  N N 257 
GLN   CD   C  N N 258 
GLN   OE1  O  N N 259 
GLN   NE2  N  N N 260 
GLN   OXT  O  N N 261 
GLN   H    H  N N 262 
GLN   H2   H  N N 263 
GLN   HA   H  N N 264 
GLN   HB2  H  N N 265 
GLN   HB3  H  N N 266 
GLN   HG2  H  N N 267 
GLN   HG3  H  N N 268 
GLN   HE21 H  N N 269 
GLN   HE22 H  N N 270 
GLN   HXT  H  N N 271 
GLU   N    N  N N 272 
GLU   CA   C  N S 273 
GLU   C    C  N N 274 
GLU   O    O  N N 275 
GLU   CB   C  N N 276 
GLU   CG   C  N N 277 
GLU   CD   C  N N 278 
GLU   OE1  O  N N 279 
GLU   OE2  O  N N 280 
GLU   OXT  O  N N 281 
GLU   H    H  N N 282 
GLU   H2   H  N N 283 
GLU   HA   H  N N 284 
GLU   HB2  H  N N 285 
GLU   HB3  H  N N 286 
GLU   HG2  H  N N 287 
GLU   HG3  H  N N 288 
GLU   HE2  H  N N 289 
GLU   HXT  H  N N 290 
GLY   N    N  N N 291 
GLY   CA   C  N N 292 
GLY   C    C  N N 293 
GLY   O    O  N N 294 
GLY   OXT  O  N N 295 
GLY   H    H  N N 296 
GLY   H2   H  N N 297 
GLY   HA2  H  N N 298 
GLY   HA3  H  N N 299 
GLY   HXT  H  N N 300 
HIS   N    N  N N 301 
HIS   CA   C  N S 302 
HIS   C    C  N N 303 
HIS   O    O  N N 304 
HIS   CB   C  N N 305 
HIS   CG   C  Y N 306 
HIS   ND1  N  Y N 307 
HIS   CD2  C  Y N 308 
HIS   CE1  C  Y N 309 
HIS   NE2  N  Y N 310 
HIS   OXT  O  N N 311 
HIS   H    H  N N 312 
HIS   H2   H  N N 313 
HIS   HA   H  N N 314 
HIS   HB2  H  N N 315 
HIS   HB3  H  N N 316 
HIS   HD1  H  N N 317 
HIS   HD2  H  N N 318 
HIS   HE1  H  N N 319 
HIS   HE2  H  N N 320 
HIS   HXT  H  N N 321 
HOH   O    O  N N 322 
HOH   H1   H  N N 323 
HOH   H2   H  N N 324 
ILE   N    N  N N 325 
ILE   CA   C  N S 326 
ILE   C    C  N N 327 
ILE   O    O  N N 328 
ILE   CB   C  N S 329 
ILE   CG1  C  N N 330 
ILE   CG2  C  N N 331 
ILE   CD1  C  N N 332 
ILE   OXT  O  N N 333 
ILE   H    H  N N 334 
ILE   H2   H  N N 335 
ILE   HA   H  N N 336 
ILE   HB   H  N N 337 
ILE   HG12 H  N N 338 
ILE   HG13 H  N N 339 
ILE   HG21 H  N N 340 
ILE   HG22 H  N N 341 
ILE   HG23 H  N N 342 
ILE   HD11 H  N N 343 
ILE   HD12 H  N N 344 
ILE   HD13 H  N N 345 
ILE   HXT  H  N N 346 
LEU   N    N  N N 347 
LEU   CA   C  N S 348 
LEU   C    C  N N 349 
LEU   O    O  N N 350 
LEU   CB   C  N N 351 
LEU   CG   C  N N 352 
LEU   CD1  C  N N 353 
LEU   CD2  C  N N 354 
LEU   OXT  O  N N 355 
LEU   H    H  N N 356 
LEU   H2   H  N N 357 
LEU   HA   H  N N 358 
LEU   HB2  H  N N 359 
LEU   HB3  H  N N 360 
LEU   HG   H  N N 361 
LEU   HD11 H  N N 362 
LEU   HD12 H  N N 363 
LEU   HD13 H  N N 364 
LEU   HD21 H  N N 365 
LEU   HD22 H  N N 366 
LEU   HD23 H  N N 367 
LEU   HXT  H  N N 368 
LYS   N    N  N N 369 
LYS   CA   C  N S 370 
LYS   C    C  N N 371 
LYS   O    O  N N 372 
LYS   CB   C  N N 373 
LYS   CG   C  N N 374 
LYS   CD   C  N N 375 
LYS   CE   C  N N 376 
LYS   NZ   N  N N 377 
LYS   OXT  O  N N 378 
LYS   H    H  N N 379 
LYS   H2   H  N N 380 
LYS   HA   H  N N 381 
LYS   HB2  H  N N 382 
LYS   HB3  H  N N 383 
LYS   HG2  H  N N 384 
LYS   HG3  H  N N 385 
LYS   HD2  H  N N 386 
LYS   HD3  H  N N 387 
LYS   HE2  H  N N 388 
LYS   HE3  H  N N 389 
LYS   HZ1  H  N N 390 
LYS   HZ2  H  N N 391 
LYS   HZ3  H  N N 392 
LYS   HXT  H  N N 393 
MET   N    N  N N 394 
MET   CA   C  N S 395 
MET   C    C  N N 396 
MET   O    O  N N 397 
MET   CB   C  N N 398 
MET   CG   C  N N 399 
MET   SD   S  N N 400 
MET   CE   C  N N 401 
MET   OXT  O  N N 402 
MET   H    H  N N 403 
MET   H2   H  N N 404 
MET   HA   H  N N 405 
MET   HB2  H  N N 406 
MET   HB3  H  N N 407 
MET   HG2  H  N N 408 
MET   HG3  H  N N 409 
MET   HE1  H  N N 410 
MET   HE2  H  N N 411 
MET   HE3  H  N N 412 
MET   HXT  H  N N 413 
PHE   N    N  N N 414 
PHE   CA   C  N S 415 
PHE   C    C  N N 416 
PHE   O    O  N N 417 
PHE   CB   C  N N 418 
PHE   CG   C  Y N 419 
PHE   CD1  C  Y N 420 
PHE   CD2  C  Y N 421 
PHE   CE1  C  Y N 422 
PHE   CE2  C  Y N 423 
PHE   CZ   C  Y N 424 
PHE   OXT  O  N N 425 
PHE   H    H  N N 426 
PHE   H2   H  N N 427 
PHE   HA   H  N N 428 
PHE   HB2  H  N N 429 
PHE   HB3  H  N N 430 
PHE   HD1  H  N N 431 
PHE   HD2  H  N N 432 
PHE   HE1  H  N N 433 
PHE   HE2  H  N N 434 
PHE   HZ   H  N N 435 
PHE   HXT  H  N N 436 
PRO   N    N  N N 437 
PRO   CA   C  N S 438 
PRO   C    C  N N 439 
PRO   O    O  N N 440 
PRO   CB   C  N N 441 
PRO   CG   C  N N 442 
PRO   CD   C  N N 443 
PRO   OXT  O  N N 444 
PRO   H    H  N N 445 
PRO   HA   H  N N 446 
PRO   HB2  H  N N 447 
PRO   HB3  H  N N 448 
PRO   HG2  H  N N 449 
PRO   HG3  H  N N 450 
PRO   HD2  H  N N 451 
PRO   HD3  H  N N 452 
PRO   HXT  H  N N 453 
SER   N    N  N N 454 
SER   CA   C  N S 455 
SER   C    C  N N 456 
SER   O    O  N N 457 
SER   CB   C  N N 458 
SER   OG   O  N N 459 
SER   OXT  O  N N 460 
SER   H    H  N N 461 
SER   H2   H  N N 462 
SER   HA   H  N N 463 
SER   HB2  H  N N 464 
SER   HB3  H  N N 465 
SER   HG   H  N N 466 
SER   HXT  H  N N 467 
THR   N    N  N N 468 
THR   CA   C  N S 469 
THR   C    C  N N 470 
THR   O    O  N N 471 
THR   CB   C  N R 472 
THR   OG1  O  N N 473 
THR   CG2  C  N N 474 
THR   OXT  O  N N 475 
THR   H    H  N N 476 
THR   H2   H  N N 477 
THR   HA   H  N N 478 
THR   HB   H  N N 479 
THR   HG1  H  N N 480 
THR   HG21 H  N N 481 
THR   HG22 H  N N 482 
THR   HG23 H  N N 483 
THR   HXT  H  N N 484 
TRP   N    N  N N 485 
TRP   CA   C  N S 486 
TRP   C    C  N N 487 
TRP   O    O  N N 488 
TRP   CB   C  N N 489 
TRP   CG   C  Y N 490 
TRP   CD1  C  Y N 491 
TRP   CD2  C  Y N 492 
TRP   NE1  N  Y N 493 
TRP   CE2  C  Y N 494 
TRP   CE3  C  Y N 495 
TRP   CZ2  C  Y N 496 
TRP   CZ3  C  Y N 497 
TRP   CH2  C  Y N 498 
TRP   OXT  O  N N 499 
TRP   H    H  N N 500 
TRP   H2   H  N N 501 
TRP   HA   H  N N 502 
TRP   HB2  H  N N 503 
TRP   HB3  H  N N 504 
TRP   HD1  H  N N 505 
TRP   HE1  H  N N 506 
TRP   HE3  H  N N 507 
TRP   HZ2  H  N N 508 
TRP   HZ3  H  N N 509 
TRP   HH2  H  N N 510 
TRP   HXT  H  N N 511 
TYR   N    N  N N 512 
TYR   CA   C  N S 513 
TYR   C    C  N N 514 
TYR   O    O  N N 515 
TYR   CB   C  N N 516 
TYR   CG   C  Y N 517 
TYR   CD1  C  Y N 518 
TYR   CD2  C  Y N 519 
TYR   CE1  C  Y N 520 
TYR   CE2  C  Y N 521 
TYR   CZ   C  Y N 522 
TYR   OH   O  N N 523 
TYR   OXT  O  N N 524 
TYR   H    H  N N 525 
TYR   H2   H  N N 526 
TYR   HA   H  N N 527 
TYR   HB2  H  N N 528 
TYR   HB3  H  N N 529 
TYR   HD1  H  N N 530 
TYR   HD2  H  N N 531 
TYR   HE1  H  N N 532 
TYR   HE2  H  N N 533 
TYR   HH   H  N N 534 
TYR   HXT  H  N N 535 
VAL   N    N  N N 536 
VAL   CA   C  N S 537 
VAL   C    C  N N 538 
VAL   O    O  N N 539 
VAL   CB   C  N N 540 
VAL   CG1  C  N N 541 
VAL   CG2  C  N N 542 
VAL   OXT  O  N N 543 
VAL   H    H  N N 544 
VAL   H2   H  N N 545 
VAL   HA   H  N N 546 
VAL   HB   H  N N 547 
VAL   HG11 H  N N 548 
VAL   HG12 H  N N 549 
VAL   HG13 H  N N 550 
VAL   HG21 H  N N 551 
VAL   HG22 H  N N 552 
VAL   HG23 H  N N 553 
VAL   HXT  H  N N 554 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1ANN C03  N02  sing N N 1   
A1ANN C04  C03  sing N N 2   
A1ANN O05  C04  sing N N 3   
A1ANN C06  O05  sing N N 4   
A1ANN C07  C06  sing N N 5   
A1ANN O08  C07  sing N N 6   
A1ANN C09  O08  sing N N 7   
A1ANN C10  C09  sing N N 8   
A1ANN O11  C10  sing N N 9   
A1ANN C12  O11  sing N N 10  
A1ANN C13  C12  sing N N 11  
A1ANN O14  C13  sing N N 12  
A1ANN C15  O14  sing N N 13  
A1ANN C16  C15  sing N N 14  
A1ANN O17  C16  sing N N 15  
A1ANN C18  O17  sing N N 16  
A1ANN C19  C18  sing N N 17  
A1ANN O20  C19  sing N N 18  
A1ANN C21  O20  sing N N 19  
A1ANN C22  C21  sing N N 20  
A1ANN N23  C22  sing N N 21  
A1ANN C24  N23  sing N N 22  
A1ANN O25  C24  doub N N 23  
A1ANN C26  C24  sing N N 24  
A1ANN C28  C27  doub Y N 25  
A1ANN C29  C28  sing Y N 26  
A1ANN F30  C29  sing N N 27  
A1ANN C31  C29  doub Y N 28  
A1ANN C32  C31  sing N N 29  
A1ANN C33  C32  doub Y N 30  
A1ANN C34  C32  sing Y N 31  
A1ANN C35  C34  doub Y N 32  
A1ANN C37  N36  sing N N 33  
A1ANN O38  C37  doub N N 34  
A1ANN C39  C37  sing N N 35  
A1ANN C40  C39  doub Y N 36  
A1ANN C42  C41  doub Y N 37  
A1ANN F43  C42  sing N N 38  
A1ANN C44  C42  sing Y N 39  
A1ANN C45  C44  doub Y N 40  
A1ANN C41  C40  sing Y N 41  
A1ANN C46  C40  sing N N 42  
A1ANN F47  C46  sing N N 43  
A1ANN F48  C46  sing N N 44  
A1ANN F49  C46  sing N N 45  
A1ANN N36  C35  sing N N 46  
A1ANN C50  C35  sing Y N 47  
A1ANN C52  N51  sing N N 48  
A1ANN C53  C52  sing N N 49  
A1ANN C54  C53  sing N N 50  
A1ANN N55  C53  sing N N 51  
A1ANN C56  N55  sing N N 52  
A1ANN C57  N55  sing N N 53  
A1ANN C58  C57  sing N N 54  
A1ANN C59  C57  sing N N 55  
A1ANN N51  C50  sing N N 56  
A1ANN C60  C50  doub Y N 57  
A1ANN C27  C26  sing Y N 58  
A1ANN C61  C26  doub Y N 59  
A1ANN N02  C01  sing N N 60  
A1ANN O62  C01  doub N N 61  
A1ANN C63  C01  sing N N 62  
A1ANN C64  C63  doub N E 63  
A1ANN C65  C64  sing N N 64  
A1ANN N66  C65  sing Y N 65  
A1ANN C67  N66  sing Y N 66  
A1ANN C68  C67  doub Y N 67  
A1ANN O70  C69  doub N N 68  
A1ANN N71  C69  sing N N 69  
A1ANN C72  N71  sing N N 70  
A1ANN C74  C73  doub Y N 71  
A1ANN C75  C74  sing Y N 72  
A1ANN CL76 C75  sing N N 73  
A1ANN C77  C75  doub Y N 74  
A1ANN F78  C77  sing N N 75  
A1ANN C79  C77  sing Y N 76  
A1ANN C80  C79  doub Y N 77  
A1ANN C73  C72  sing N N 78  
A1ANN C81  C72  sing N N 79  
A1ANN C82  C81  sing N N 80  
A1ANN O83  C82  doub N N 81  
A1ANN N84  C82  sing N N 82  
A1ANN C69  C68  sing N N 83  
A1ANN C85  C68  sing Y N 84  
A1ANN C86  C85  sing N N 85  
A1ANN C87  C86  doub Y N 86  
A1ANN C88  C87  sing Y N 87  
A1ANN C89  C88  doub Y N 88  
A1ANN CL90 C89  sing N N 89  
A1ANN C91  C89  sing Y N 90  
A1ANN C92  C91  doub Y N 91  
A1ANN F93  C92  sing N N 92  
A1ANN C31  C61  sing Y N 93  
A1ANN C33  C60  sing Y N 94  
A1ANN C39  C45  sing Y N 95  
A1ANN N51  C59  sing N N 96  
A1ANN C65  C85  doub Y N 97  
A1ANN C73  C80  sing Y N 98  
A1ANN C86  C92  sing Y N 99  
A1ANN C18  H181 sing N N 100 
A1ANN C18  H182 sing N N 101 
A1ANN C19  H192 sing N N 102 
A1ANN C19  H191 sing N N 103 
A1ANN C21  H211 sing N N 104 
A1ANN C21  H212 sing N N 105 
A1ANN C22  H221 sing N N 106 
A1ANN C22  H222 sing N N 107 
A1ANN C03  H032 sing N N 108 
A1ANN C03  H031 sing N N 109 
A1ANN C04  H042 sing N N 110 
A1ANN C04  H041 sing N N 111 
A1ANN C06  H062 sing N N 112 
A1ANN C06  H061 sing N N 113 
A1ANN C07  H072 sing N N 114 
A1ANN C07  H071 sing N N 115 
A1ANN C09  H091 sing N N 116 
A1ANN C09  H092 sing N N 117 
A1ANN C10  H102 sing N N 118 
A1ANN C10  H101 sing N N 119 
A1ANN C12  H122 sing N N 120 
A1ANN C12  H121 sing N N 121 
A1ANN C13  H132 sing N N 122 
A1ANN C13  H131 sing N N 123 
A1ANN C15  H151 sing N N 124 
A1ANN C15  H152 sing N N 125 
A1ANN C16  H161 sing N N 126 
A1ANN C16  H162 sing N N 127 
A1ANN C27  H271 sing N N 128 
A1ANN C28  H281 sing N N 129 
A1ANN C33  H331 sing N N 130 
A1ANN C34  H341 sing N N 131 
A1ANN C41  H411 sing N N 132 
A1ANN C44  H441 sing N N 133 
A1ANN C45  H451 sing N N 134 
A1ANN C52  H522 sing N N 135 
A1ANN C52  H521 sing N N 136 
A1ANN C53  H531 sing N N 137 
A1ANN C54  H541 sing N N 138 
A1ANN C54  H542 sing N N 139 
A1ANN C54  H543 sing N N 140 
A1ANN C56  H562 sing N N 141 
A1ANN C56  H561 sing N N 142 
A1ANN C56  H563 sing N N 143 
A1ANN C57  H571 sing N N 144 
A1ANN C58  H581 sing N N 145 
A1ANN C58  H582 sing N N 146 
A1ANN C58  H583 sing N N 147 
A1ANN C59  H592 sing N N 148 
A1ANN C59  H591 sing N N 149 
A1ANN C60  H601 sing N N 150 
A1ANN C61  H611 sing N N 151 
A1ANN C63  H631 sing N N 152 
A1ANN C64  H641 sing N N 153 
A1ANN C67  H671 sing N N 154 
A1ANN C72  H721 sing N N 155 
A1ANN C74  H741 sing N N 156 
A1ANN C79  H791 sing N N 157 
A1ANN C80  H801 sing N N 158 
A1ANN C81  H812 sing N N 159 
A1ANN C81  H811 sing N N 160 
A1ANN C87  H871 sing N N 161 
A1ANN C88  H881 sing N N 162 
A1ANN C91  H911 sing N N 163 
A1ANN N02  H021 sing N N 164 
A1ANN N23  H231 sing N N 165 
A1ANN N36  H361 sing N N 166 
A1ANN N66  H661 sing N N 167 
A1ANN N71  H711 sing N N 168 
A1ANN N84  H841 sing N N 169 
A1ANN N84  H842 sing N N 170 
ALA   N    CA   sing N N 171 
ALA   N    H    sing N N 172 
ALA   N    H2   sing N N 173 
ALA   CA   C    sing N N 174 
ALA   CA   CB   sing N N 175 
ALA   CA   HA   sing N N 176 
ALA   C    O    doub N N 177 
ALA   C    OXT  sing N N 178 
ALA   CB   HB1  sing N N 179 
ALA   CB   HB2  sing N N 180 
ALA   CB   HB3  sing N N 181 
ALA   OXT  HXT  sing N N 182 
ARG   N    CA   sing N N 183 
ARG   N    H    sing N N 184 
ARG   N    H2   sing N N 185 
ARG   CA   C    sing N N 186 
ARG   CA   CB   sing N N 187 
ARG   CA   HA   sing N N 188 
ARG   C    O    doub N N 189 
ARG   C    OXT  sing N N 190 
ARG   CB   CG   sing N N 191 
ARG   CB   HB2  sing N N 192 
ARG   CB   HB3  sing N N 193 
ARG   CG   CD   sing N N 194 
ARG   CG   HG2  sing N N 195 
ARG   CG   HG3  sing N N 196 
ARG   CD   NE   sing N N 197 
ARG   CD   HD2  sing N N 198 
ARG   CD   HD3  sing N N 199 
ARG   NE   CZ   sing N N 200 
ARG   NE   HE   sing N N 201 
ARG   CZ   NH1  sing N N 202 
ARG   CZ   NH2  doub N N 203 
ARG   NH1  HH11 sing N N 204 
ARG   NH1  HH12 sing N N 205 
ARG   NH2  HH21 sing N N 206 
ARG   NH2  HH22 sing N N 207 
ARG   OXT  HXT  sing N N 208 
ASN   N    CA   sing N N 209 
ASN   N    H    sing N N 210 
ASN   N    H2   sing N N 211 
ASN   CA   C    sing N N 212 
ASN   CA   CB   sing N N 213 
ASN   CA   HA   sing N N 214 
ASN   C    O    doub N N 215 
ASN   C    OXT  sing N N 216 
ASN   CB   CG   sing N N 217 
ASN   CB   HB2  sing N N 218 
ASN   CB   HB3  sing N N 219 
ASN   CG   OD1  doub N N 220 
ASN   CG   ND2  sing N N 221 
ASN   ND2  HD21 sing N N 222 
ASN   ND2  HD22 sing N N 223 
ASN   OXT  HXT  sing N N 224 
ASP   N    CA   sing N N 225 
ASP   N    H    sing N N 226 
ASP   N    H2   sing N N 227 
ASP   CA   C    sing N N 228 
ASP   CA   CB   sing N N 229 
ASP   CA   HA   sing N N 230 
ASP   C    O    doub N N 231 
ASP   C    OXT  sing N N 232 
ASP   CB   CG   sing N N 233 
ASP   CB   HB2  sing N N 234 
ASP   CB   HB3  sing N N 235 
ASP   CG   OD1  doub N N 236 
ASP   CG   OD2  sing N N 237 
ASP   OD2  HD2  sing N N 238 
ASP   OXT  HXT  sing N N 239 
CYS   N    CA   sing N N 240 
CYS   N    H    sing N N 241 
CYS   N    H2   sing N N 242 
CYS   CA   C    sing N N 243 
CYS   CA   CB   sing N N 244 
CYS   CA   HA   sing N N 245 
CYS   C    O    doub N N 246 
CYS   C    OXT  sing N N 247 
CYS   CB   SG   sing N N 248 
CYS   CB   HB2  sing N N 249 
CYS   CB   HB3  sing N N 250 
CYS   SG   HG   sing N N 251 
CYS   OXT  HXT  sing N N 252 
GLN   N    CA   sing N N 253 
GLN   N    H    sing N N 254 
GLN   N    H2   sing N N 255 
GLN   CA   C    sing N N 256 
GLN   CA   CB   sing N N 257 
GLN   CA   HA   sing N N 258 
GLN   C    O    doub N N 259 
GLN   C    OXT  sing N N 260 
GLN   CB   CG   sing N N 261 
GLN   CB   HB2  sing N N 262 
GLN   CB   HB3  sing N N 263 
GLN   CG   CD   sing N N 264 
GLN   CG   HG2  sing N N 265 
GLN   CG   HG3  sing N N 266 
GLN   CD   OE1  doub N N 267 
GLN   CD   NE2  sing N N 268 
GLN   NE2  HE21 sing N N 269 
GLN   NE2  HE22 sing N N 270 
GLN   OXT  HXT  sing N N 271 
GLU   N    CA   sing N N 272 
GLU   N    H    sing N N 273 
GLU   N    H2   sing N N 274 
GLU   CA   C    sing N N 275 
GLU   CA   CB   sing N N 276 
GLU   CA   HA   sing N N 277 
GLU   C    O    doub N N 278 
GLU   C    OXT  sing N N 279 
GLU   CB   CG   sing N N 280 
GLU   CB   HB2  sing N N 281 
GLU   CB   HB3  sing N N 282 
GLU   CG   CD   sing N N 283 
GLU   CG   HG2  sing N N 284 
GLU   CG   HG3  sing N N 285 
GLU   CD   OE1  doub N N 286 
GLU   CD   OE2  sing N N 287 
GLU   OE2  HE2  sing N N 288 
GLU   OXT  HXT  sing N N 289 
GLY   N    CA   sing N N 290 
GLY   N    H    sing N N 291 
GLY   N    H2   sing N N 292 
GLY   CA   C    sing N N 293 
GLY   CA   HA2  sing N N 294 
GLY   CA   HA3  sing N N 295 
GLY   C    O    doub N N 296 
GLY   C    OXT  sing N N 297 
GLY   OXT  HXT  sing N N 298 
HIS   N    CA   sing N N 299 
HIS   N    H    sing N N 300 
HIS   N    H2   sing N N 301 
HIS   CA   C    sing N N 302 
HIS   CA   CB   sing N N 303 
HIS   CA   HA   sing N N 304 
HIS   C    O    doub N N 305 
HIS   C    OXT  sing N N 306 
HIS   CB   CG   sing N N 307 
HIS   CB   HB2  sing N N 308 
HIS   CB   HB3  sing N N 309 
HIS   CG   ND1  sing Y N 310 
HIS   CG   CD2  doub Y N 311 
HIS   ND1  CE1  doub Y N 312 
HIS   ND1  HD1  sing N N 313 
HIS   CD2  NE2  sing Y N 314 
HIS   CD2  HD2  sing N N 315 
HIS   CE1  NE2  sing Y N 316 
HIS   CE1  HE1  sing N N 317 
HIS   NE2  HE2  sing N N 318 
HIS   OXT  HXT  sing N N 319 
HOH   O    H1   sing N N 320 
HOH   O    H2   sing N N 321 
ILE   N    CA   sing N N 322 
ILE   N    H    sing N N 323 
ILE   N    H2   sing N N 324 
ILE   CA   C    sing N N 325 
ILE   CA   CB   sing N N 326 
ILE   CA   HA   sing N N 327 
ILE   C    O    doub N N 328 
ILE   C    OXT  sing N N 329 
ILE   CB   CG1  sing N N 330 
ILE   CB   CG2  sing N N 331 
ILE   CB   HB   sing N N 332 
ILE   CG1  CD1  sing N N 333 
ILE   CG1  HG12 sing N N 334 
ILE   CG1  HG13 sing N N 335 
ILE   CG2  HG21 sing N N 336 
ILE   CG2  HG22 sing N N 337 
ILE   CG2  HG23 sing N N 338 
ILE   CD1  HD11 sing N N 339 
ILE   CD1  HD12 sing N N 340 
ILE   CD1  HD13 sing N N 341 
ILE   OXT  HXT  sing N N 342 
LEU   N    CA   sing N N 343 
LEU   N    H    sing N N 344 
LEU   N    H2   sing N N 345 
LEU   CA   C    sing N N 346 
LEU   CA   CB   sing N N 347 
LEU   CA   HA   sing N N 348 
LEU   C    O    doub N N 349 
LEU   C    OXT  sing N N 350 
LEU   CB   CG   sing N N 351 
LEU   CB   HB2  sing N N 352 
LEU   CB   HB3  sing N N 353 
LEU   CG   CD1  sing N N 354 
LEU   CG   CD2  sing N N 355 
LEU   CG   HG   sing N N 356 
LEU   CD1  HD11 sing N N 357 
LEU   CD1  HD12 sing N N 358 
LEU   CD1  HD13 sing N N 359 
LEU   CD2  HD21 sing N N 360 
LEU   CD2  HD22 sing N N 361 
LEU   CD2  HD23 sing N N 362 
LEU   OXT  HXT  sing N N 363 
LYS   N    CA   sing N N 364 
LYS   N    H    sing N N 365 
LYS   N    H2   sing N N 366 
LYS   CA   C    sing N N 367 
LYS   CA   CB   sing N N 368 
LYS   CA   HA   sing N N 369 
LYS   C    O    doub N N 370 
LYS   C    OXT  sing N N 371 
LYS   CB   CG   sing N N 372 
LYS   CB   HB2  sing N N 373 
LYS   CB   HB3  sing N N 374 
LYS   CG   CD   sing N N 375 
LYS   CG   HG2  sing N N 376 
LYS   CG   HG3  sing N N 377 
LYS   CD   CE   sing N N 378 
LYS   CD   HD2  sing N N 379 
LYS   CD   HD3  sing N N 380 
LYS   CE   NZ   sing N N 381 
LYS   CE   HE2  sing N N 382 
LYS   CE   HE3  sing N N 383 
LYS   NZ   HZ1  sing N N 384 
LYS   NZ   HZ2  sing N N 385 
LYS   NZ   HZ3  sing N N 386 
LYS   OXT  HXT  sing N N 387 
MET   N    CA   sing N N 388 
MET   N    H    sing N N 389 
MET   N    H2   sing N N 390 
MET   CA   C    sing N N 391 
MET   CA   CB   sing N N 392 
MET   CA   HA   sing N N 393 
MET   C    O    doub N N 394 
MET   C    OXT  sing N N 395 
MET   CB   CG   sing N N 396 
MET   CB   HB2  sing N N 397 
MET   CB   HB3  sing N N 398 
MET   CG   SD   sing N N 399 
MET   CG   HG2  sing N N 400 
MET   CG   HG3  sing N N 401 
MET   SD   CE   sing N N 402 
MET   CE   HE1  sing N N 403 
MET   CE   HE2  sing N N 404 
MET   CE   HE3  sing N N 405 
MET   OXT  HXT  sing N N 406 
PHE   N    CA   sing N N 407 
PHE   N    H    sing N N 408 
PHE   N    H2   sing N N 409 
PHE   CA   C    sing N N 410 
PHE   CA   CB   sing N N 411 
PHE   CA   HA   sing N N 412 
PHE   C    O    doub N N 413 
PHE   C    OXT  sing N N 414 
PHE   CB   CG   sing N N 415 
PHE   CB   HB2  sing N N 416 
PHE   CB   HB3  sing N N 417 
PHE   CG   CD1  doub Y N 418 
PHE   CG   CD2  sing Y N 419 
PHE   CD1  CE1  sing Y N 420 
PHE   CD1  HD1  sing N N 421 
PHE   CD2  CE2  doub Y N 422 
PHE   CD2  HD2  sing N N 423 
PHE   CE1  CZ   doub Y N 424 
PHE   CE1  HE1  sing N N 425 
PHE   CE2  CZ   sing Y N 426 
PHE   CE2  HE2  sing N N 427 
PHE   CZ   HZ   sing N N 428 
PHE   OXT  HXT  sing N N 429 
PRO   N    CA   sing N N 430 
PRO   N    CD   sing N N 431 
PRO   N    H    sing N N 432 
PRO   CA   C    sing N N 433 
PRO   CA   CB   sing N N 434 
PRO   CA   HA   sing N N 435 
PRO   C    O    doub N N 436 
PRO   C    OXT  sing N N 437 
PRO   CB   CG   sing N N 438 
PRO   CB   HB2  sing N N 439 
PRO   CB   HB3  sing N N 440 
PRO   CG   CD   sing N N 441 
PRO   CG   HG2  sing N N 442 
PRO   CG   HG3  sing N N 443 
PRO   CD   HD2  sing N N 444 
PRO   CD   HD3  sing N N 445 
PRO   OXT  HXT  sing N N 446 
SER   N    CA   sing N N 447 
SER   N    H    sing N N 448 
SER   N    H2   sing N N 449 
SER   CA   C    sing N N 450 
SER   CA   CB   sing N N 451 
SER   CA   HA   sing N N 452 
SER   C    O    doub N N 453 
SER   C    OXT  sing N N 454 
SER   CB   OG   sing N N 455 
SER   CB   HB2  sing N N 456 
SER   CB   HB3  sing N N 457 
SER   OG   HG   sing N N 458 
SER   OXT  HXT  sing N N 459 
THR   N    CA   sing N N 460 
THR   N    H    sing N N 461 
THR   N    H2   sing N N 462 
THR   CA   C    sing N N 463 
THR   CA   CB   sing N N 464 
THR   CA   HA   sing N N 465 
THR   C    O    doub N N 466 
THR   C    OXT  sing N N 467 
THR   CB   OG1  sing N N 468 
THR   CB   CG2  sing N N 469 
THR   CB   HB   sing N N 470 
THR   OG1  HG1  sing N N 471 
THR   CG2  HG21 sing N N 472 
THR   CG2  HG22 sing N N 473 
THR   CG2  HG23 sing N N 474 
THR   OXT  HXT  sing N N 475 
TRP   N    CA   sing N N 476 
TRP   N    H    sing N N 477 
TRP   N    H2   sing N N 478 
TRP   CA   C    sing N N 479 
TRP   CA   CB   sing N N 480 
TRP   CA   HA   sing N N 481 
TRP   C    O    doub N N 482 
TRP   C    OXT  sing N N 483 
TRP   CB   CG   sing N N 484 
TRP   CB   HB2  sing N N 485 
TRP   CB   HB3  sing N N 486 
TRP   CG   CD1  doub Y N 487 
TRP   CG   CD2  sing Y N 488 
TRP   CD1  NE1  sing Y N 489 
TRP   CD1  HD1  sing N N 490 
TRP   CD2  CE2  doub Y N 491 
TRP   CD2  CE3  sing Y N 492 
TRP   NE1  CE2  sing Y N 493 
TRP   NE1  HE1  sing N N 494 
TRP   CE2  CZ2  sing Y N 495 
TRP   CE3  CZ3  doub Y N 496 
TRP   CE3  HE3  sing N N 497 
TRP   CZ2  CH2  doub Y N 498 
TRP   CZ2  HZ2  sing N N 499 
TRP   CZ3  CH2  sing Y N 500 
TRP   CZ3  HZ3  sing N N 501 
TRP   CH2  HH2  sing N N 502 
TRP   OXT  HXT  sing N N 503 
TYR   N    CA   sing N N 504 
TYR   N    H    sing N N 505 
TYR   N    H2   sing N N 506 
TYR   CA   C    sing N N 507 
TYR   CA   CB   sing N N 508 
TYR   CA   HA   sing N N 509 
TYR   C    O    doub N N 510 
TYR   C    OXT  sing N N 511 
TYR   CB   CG   sing N N 512 
TYR   CB   HB2  sing N N 513 
TYR   CB   HB3  sing N N 514 
TYR   CG   CD1  doub Y N 515 
TYR   CG   CD2  sing Y N 516 
TYR   CD1  CE1  sing Y N 517 
TYR   CD1  HD1  sing N N 518 
TYR   CD2  CE2  doub Y N 519 
TYR   CD2  HD2  sing N N 520 
TYR   CE1  CZ   doub Y N 521 
TYR   CE1  HE1  sing N N 522 
TYR   CE2  CZ   sing Y N 523 
TYR   CE2  HE2  sing N N 524 
TYR   CZ   OH   sing N N 525 
TYR   OH   HH   sing N N 526 
TYR   OXT  HXT  sing N N 527 
VAL   N    CA   sing N N 528 
VAL   N    H    sing N N 529 
VAL   N    H2   sing N N 530 
VAL   CA   C    sing N N 531 
VAL   CA   CB   sing N N 532 
VAL   CA   HA   sing N N 533 
VAL   C    O    doub N N 534 
VAL   C    OXT  sing N N 535 
VAL   CB   CG1  sing N N 536 
VAL   CB   CG2  sing N N 537 
VAL   CB   HB   sing N N 538 
VAL   CG1  HG11 sing N N 539 
VAL   CG1  HG12 sing N N 540 
VAL   CG1  HG13 sing N N 541 
VAL   CG2  HG21 sing N N 542 
VAL   CG2  HG22 sing N N 543 
VAL   CG2  HG23 sing N N 544 
VAL   OXT  HXT  sing N N 545 
# 
_pdbx_audit_support.funding_organization   'Ontario Institute for Cancer Research' 
_pdbx_audit_support.country                Canada 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
loop_
_pdbx_initial_refinement_model.id 
_pdbx_initial_refinement_model.entity_id_list 
_pdbx_initial_refinement_model.type 
_pdbx_initial_refinement_model.source_name 
_pdbx_initial_refinement_model.accession_code 
_pdbx_initial_refinement_model.details 
1 ? 'experimental model' PDB 8F8E ? 
2 ? 'experimental model' PDB 2GNQ ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9B9W 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.012516 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.011971 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.007644 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
CL ? ? 9.50761 7.44341 ? ? 1.04373  23.83732 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F  ? ? 4.90428 4.07044 ? ? 12.99538 1.63651  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N    . VAL   A 1 26  ? -4.51114  0.96843   19.74479  1.000 45.08808 ? 31   VAL   A N    1 
ATOM   2    C  CA   . VAL   A 1 26  ? -3.33414  0.11741   19.59990  1.000 49.01706 ? 31   VAL   A CA   1 
ATOM   3    C  C    . VAL   A 1 26  ? -3.39713  -0.74973  18.34999  1.000 49.12401 ? 31   VAL   A C    1 
ATOM   4    O  O    . VAL   A 1 26  ? -4.46712  -1.01878  17.79601  1.000 45.35585 ? 31   VAL   A O    1 
ATOM   5    C  CB   . VAL   A 1 26  ? -3.12516  -0.80046  20.82100  1.000 48.92202 ? 31   VAL   A CB   1 
ATOM   6    C  CG1  . VAL   A 1 26  ? -2.39918  -0.06533  21.95093  1.000 59.12329 ? 31   VAL   A CG1  1 
ATOM   7    C  CG2  . VAL   A 1 26  ? -4.45617  -1.39940  21.27805  1.000 50.63676 ? 31   VAL   A CG2  1 
ATOM   8    N  N    . LYS   A 1 27  ? -2.22312  -1.19578  17.93106  1.000 36.63303 ? 32   LYS   A N    1 
ATOM   9    C  CA   . LYS   A 1 27  ? -2.05111  -2.16490  16.86717  1.000 40.14562 ? 32   LYS   A CA   1 
ATOM   10   C  C    . LYS   A 1 27  ? -1.19312  -3.30584  17.38731  1.000 42.44966 ? 32   LYS   A C    1 
ATOM   11   O  O    . LYS   A 1 27  ? -0.34013  -3.09775  18.25730  1.000 36.79111 ? 32   LYS   A O    1 
ATOM   12   C  CB   . LYS   A 1 27  ? -1.36009  -1.55003  15.64511  1.000 34.72176 ? 32   LYS   A CB   1 
ATOM   13   C  CG   . LYS   A 1 27  ? -2.05907  -0.36110  15.00097  1.000 46.76434 ? 32   LYS   A CG   1 
ATOM   14   C  CD   . LYS   A 1 27  ? -1.28005  0.03476   13.74394  1.000 47.86429 ? 32   LYS   A CD   1 
ATOM   15   C  CE   . LYS   A 1 27  ? -1.60004  1.43970   13.25678  1.000 54.01304 ? 32   LYS   A CE   1 
ATOM   16   N  NZ   . LYS   A 1 27  ? -0.62202  1.86458   12.19775  1.000 69.69051 ? 32   LYS   A NZ   1 
ATOM   17   N  N    . PRO   A 1 28  ? -1.37512  -4.51190  16.86344  1.000 35.15991 ? 33   PRO   A N    1 
ATOM   18   C  CA   . PRO   A 1 28  ? -0.45713  -5.59986  17.21458  1.000 28.06836 ? 33   PRO   A CA   1 
ATOM   19   C  C    . PRO   A 1 28  ? 0.88089   -5.36694  16.53557  1.000 26.53118 ? 33   PRO   A C    1 
ATOM   20   O  O    . PRO   A 1 28  ? 1.04190   -4.49204  15.68748  1.000 27.78970 ? 33   PRO   A O    1 
ATOM   21   C  CB   . PRO   A 1 28  ? -1.17312  -6.84692  16.68570  1.000 26.00395 ? 33   PRO   A CB   1 
ATOM   22   C  CG   . PRO   A 1 28  ? -1.90810  -6.33205  15.44963  1.000 26.41818 ? 33   PRO   A CG   1 
ATOM   23   C  CD   . PRO   A 1 28  ? -2.27110  -4.87802  15.74947  1.000 27.31676 ? 33   PRO   A CD   1 
ATOM   24   N  N    . ASN   A 1 29  ? 1.87188   -6.15190  16.92667  1.000 29.69951 ? 34   ASN   A N    1 
ATOM   25   C  CA   . ASN   A 1 29  ? 3.18589   -6.03798  16.30968  1.000 28.31157 ? 34   ASN   A CA   1 
ATOM   26   C  C    . ASN   A 1 29  ? 3.72089   -7.41402  15.98684  1.000 31.28261 ? 34   ASN   A C    1 
ATOM   27   O  O    . ASN   A 1 29  ? 4.85388   -7.76798  16.31190  1.000 29.63124 ? 34   ASN   A O    1 
ATOM   28   C  CB   . ASN   A 1 29  ? 4.15988   -5.26388  17.19261  1.000 29.01181 ? 34   ASN   A CB   1 
ATOM   29   C  CG   . ASN   A 1 29  ? 4.36785   -5.92073  18.54469  1.000 35.54770 ? 34   ASN   A CG   1 
ATOM   30   O  OD1  . ASN   A 1 29  ? 3.68484   -6.88469  18.88778  1.000 34.97874 ? 34   ASN   A OD1  1 
ATOM   31   N  ND2  . ASN   A 1 29  ? 5.29884   -5.38765  19.33164  1.000 33.34039 ? 34   ASN   A ND2  1 
ATOM   32   N  N    . TYR   A 1 30  ? 2.89089   -8.21908  15.33092  1.000 28.45834 ? 35   TYR   A N    1 
ATOM   33   C  CA   . TYR   A 1 30  ? 3.31590   -9.55213  14.92607  1.000 27.06899 ? 35   TYR   A CA   1 
ATOM   34   C  C    . TYR   A 1 30  ? 4.62591   -9.48722  14.15709  1.000 23.25772 ? 35   TYR   A C    1 
ATOM   35   O  O    . TYR   A 1 30  ? 4.80193   -8.65832  13.25700  1.000 28.07956 ? 35   TYR   A O    1 
ATOM   36   C  CB   . TYR   A 1 30  ? 2.22691   -10.22122 14.08113  1.000 22.77372 ? 35   TYR   A CB   1 
ATOM   37   C  CG   . TYR   A 1 30  ? 1.14189   -10.77312 14.94917  1.000 24.74150 ? 35   TYR   A CG   1 
ATOM   38   C  CD1  . TYR   A 1 30  ? 1.28188   -12.01806 15.53831  1.000 21.62881 ? 35   TYR   A CD1  1 
ATOM   39   C  CD2  . TYR   A 1 30  ? -0.00911  -10.03109 15.22607  1.000 26.19044 ? 35   TYR   A CD2  1 
ATOM   40   C  CE1  . TYR   A 1 30  ? 0.29386   -12.52996 16.35735  1.000 23.77869 ? 35   TYR   A CE1  1 
ATOM   41   C  CE2  . TYR   A 1 30  ? -0.99513  -10.53099 16.04711  1.000 22.28546 ? 35   TYR   A CE2  1 
ATOM   42   C  CZ   . TYR   A 1 30  ? -0.84014  -11.78193 16.61125  1.000 25.53783 ? 35   TYR   A CZ   1 
ATOM   43   O  OH   . TYR   A 1 30  ? -1.81915  -12.30583 17.43429  1.000 26.12632 ? 35   TYR   A OH   1 
ATOM   44   N  N    . ALA   A 1 31  ? 5.55690   -10.35618 14.53920  1.000 24.48063 ? 36   ALA   A N    1 
ATOM   45   C  CA   . ALA   A 1 31  ? 6.82291   -10.49326 13.85323  1.000 25.97262 ? 36   ALA   A CA   1 
ATOM   46   C  C    . ALA   A 1 31  ? 7.10891   -11.96929 13.63440  1.000 26.10731 ? 36   ALA   A C    1 
ATOM   47   O  O    . ALA   A 1 31  ? 6.69389   -12.82620 14.41749  1.000 25.83421 ? 36   ALA   A O    1 
ATOM   48   C  CB   . ALA   A 1 31  ? 7.96590   -9.84918  14.63318  1.000 30.16527 ? 36   ALA   A CB   1 
ATOM   49   N  N    . LEU   A 1 32  ? 7.83792   -12.24541 12.56344  1.000 23.18340 ? 37   LEU   A N    1 
ATOM   50   C  CA   . LEU   A 1 32  ? 8.12293   -13.61245 12.15960  1.000 23.29556 ? 37   LEU   A CA   1 
ATOM   51   C  C    . LEU   A 1 32  ? 9.08991   -14.29135 13.12969  1.000 29.00747 ? 37   LEU   A C    1 
ATOM   52   O  O    . LEU   A 1 32  ? 10.19091  -13.78633 13.37365  1.000 25.64533 ? 37   LEU   A O    1 
ATOM   53   C  CB   . LEU   A 1 32  ? 8.71695   -13.59661 10.75961  1.000 19.28393 ? 37   LEU   A CB   1 
ATOM   54   C  CG   . LEU   A 1 32  ? 9.00995   -14.96768 10.18076  1.000 21.91690 ? 37   LEU   A CG   1 
ATOM   55   C  CD1  . LEU   A 1 32  ? 7.70995   -15.77468 10.08983  1.000 23.44850 ? 37   LEU   A CD1  1 
ATOM   56   C  CD2  . LEU   A 1 32  ? 9.62897   -14.77983 8.80475   1.000 23.10208 ? 37   LEU   A CD2  1 
ATOM   57   N  N    . LYS   A 1 33  ? 8.69389   -15.45129 13.65981  1.000 28.37326 ? 38   LYS   A N    1 
ATOM   58   C  CA   . LYS   A 1 33  ? 9.53388   -16.23119 14.56691  1.000 27.96638 ? 38   LYS   A CA   1 
ATOM   59   C  C    . LYS   A 1 33  ? 10.07888  -17.50126 13.93906  1.000 28.46420 ? 38   LYS   A C    1 
ATOM   60   O  O    . LYS   A 1 33  ? 11.25588  -17.80125 14.10411  1.000 27.45963 ? 38   LYS   A O    1 
ATOM   61   C  CB   . LYS   A 1 33  ? 8.76186   -16.59705 15.84294  1.000 24.06988 ? 38   LYS   A CB   1 
ATOM   62   C  CG   . LYS   A 1 33  ? 8.13585   -15.42597 16.56180  1.000 26.86742 ? 38   LYS   A CG   1 
ATOM   63   C  CD   . LYS   A 1 33  ? 9.14585   -14.31094 16.82869  1.000 29.66052 ? 38   LYS   A CD   1 
ATOM   64   C  CE   . LYS   A 1 33  ? 10.28083  -14.76985 17.72676  1.000 33.51134 ? 38   LYS   A CE   1 
ATOM   65   N  NZ   . LYS   A 1 33  ? 9.79581   -15.27870 19.02581  1.000 29.79341 ? 38   LYS   A NZ   1 
ATOM   66   N  N    . PHE   A 1 34  ? 9.26389   -18.25134 13.19913  1.000 23.91275 ? 39   PHE   A N    1 
ATOM   67   C  CA   . PHE   A 1 34  ? 9.72790   -19.47642 12.55927  1.000 26.62980 ? 39   PHE   A CA   1 
ATOM   68   C  C    . PHE   A 1 34  ? 9.08792   -19.62156 11.19328  1.000 24.91931 ? 39   PHE   A C    1 
ATOM   69   O  O    . PHE   A 1 34  ? 7.95192   -19.19958 10.97821  1.000 26.39045 ? 39   PHE   A O    1 
ATOM   70   C  CB   . PHE   A 1 34  ? 9.40788   -20.72232 13.39140  1.000 25.68615 ? 39   PHE   A CB   1 
ATOM   71   C  CG   . PHE   A 1 34  ? 9.92286   -20.64317 14.78740  1.000 30.28272 ? 39   PHE   A CG   1 
ATOM   72   C  CD1  . PHE   A 1 34  ? 11.24985  -20.96414 15.06846  1.000 34.27360 ? 39   PHE   A CD1  1 
ATOM   73   C  CD2  . PHE   A 1 34  ? 9.10484   -20.20805 15.81634  1.000 26.20193 ? 39   PHE   A CD2  1 
ATOM   74   C  CE1  . PHE   A 1 34  ? 11.73983  -20.87600 16.35846  1.000 29.52356 ? 39   PHE   A CE1  1 
ATOM   75   C  CE2  . PHE   A 1 34  ? 9.59682   -20.10591 17.12034  1.000 31.62888 ? 39   PHE   A CE2  1 
ATOM   76   C  CZ   . PHE   A 1 34  ? 10.91182  -20.45089 17.38840  1.000 31.43355 ? 39   PHE   A CZ   1 
ATOM   77   N  N    . THR   A 1 35  ? 9.83293   -20.22467 10.27435  1.000 22.95460 ? 40   THR   A N    1 
ATOM   78   C  CA   . THR   A 1 35  ? 9.30095   -20.68781 9.00340   1.000 22.69205 ? 40   THR   A CA   1 
ATOM   79   C  C    . THR   A 1 35  ? 9.43194   -22.20381 8.97957   1.000 23.67605 ? 40   THR   A C    1 
ATOM   80   O  O    . THR   A 1 35  ? 10.53094  -22.74080 9.15464   1.000 23.98207 ? 40   THR   A O    1 
ATOM   81   C  CB   . THR   A 1 35  ? 10.03397  -20.03994 7.82434   1.000 22.84423 ? 40   THR   A CB   1 
ATOM   82   O  OG1  . THR   A 1 35  ? 9.82498   -18.61894 7.86018   1.000 22.18672 ? 40   THR   A OG1  1 
ATOM   83   C  CG2  . THR   A 1 35  ? 9.50899   -20.59509 6.49039   1.000 21.31442 ? 40   THR   A CG2  1 
ATOM   84   N  N    . LEU   A 1 36  ? 8.31594   -22.89083 8.78563   1.000 18.15500 ? 41   LEU   A N    1 
ATOM   85   C  CA   . LEU   A 1 36  ? 8.25494   -24.34882 8.84379   1.000 22.26956 ? 41   LEU   A CA   1 
ATOM   86   C  C    . LEU   A 1 36  ? 8.26396   -24.87898 7.42184   1.000 23.73613 ? 41   LEU   A C    1 
ATOM   87   O  O    . LEU   A 1 36  ? 7.32297   -24.64306 6.65680   1.000 25.45656 ? 41   LEU   A O    1 
ATOM   88   C  CB   . LEU   A 1 36  ? 6.99392   -24.80973 9.57882   1.000 20.56470 ? 41   LEU   A CB   1 
ATOM   89   C  CG   . LEU   A 1 36  ? 6.91590   -24.64757 11.10080  1.000 28.00297 ? 41   LEU   A CG   1 
ATOM   90   C  CD1  . LEU   A 1 36  ? 7.53690   -23.33752 11.56066  1.000 29.60361 ? 41   LEU   A CD1  1 
ATOM   91   C  CD2  . LEU   A 1 36  ? 5.45289   -24.79251 11.58479  1.000 22.97318 ? 41   LEU   A CD2  1 
ATOM   92   N  N    . ALA   A 1 37  ? 9.32696   -25.58102 7.05294   1.000 22.99727 ? 42   ALA   A N    1 
ATOM   93   C  CA   . ALA   A 1 37  ? 9.45498   -26.11417 5.70700   1.000 25.17808 ? 42   ALA   A CA   1 
ATOM   94   C  C    . ALA   A 1 37  ? 9.42397   -27.63216 5.78617   1.000 25.17036 ? 42   ALA   A C    1 
ATOM   95   O  O    . ALA   A 1 37  ? 9.91096   -28.21506 6.75624   1.000 25.11452 ? 42   ALA   A O    1 
ATOM   96   C  CB   . ALA   A 1 37  ? 10.73999  -25.62125 5.03497   1.000 25.95403 ? 42   ALA   A CB   1 
ATOM   97   N  N    . GLY   A 1 38  ? 8.82599   -28.26927 4.78523   1.000 23.99277 ? 43   GLY   A N    1 
ATOM   98   C  CA   . GLY   A 1 38  ? 8.71698   -29.71227 4.81738   1.000 25.12337 ? 43   GLY   A CA   1 
ATOM   99   C  C    . GLY   A 1 38  ? 7.68800   -30.27037 3.85643   1.000 31.55698 ? 43   GLY   A C    1 
ATOM   100  O  O    . GLY   A 1 38  ? 7.92700   -31.32044 3.25155   1.000 23.47874 ? 43   GLY   A O    1 
ATOM   101  N  N    . HIS   A 1 39  ? 6.53500   -29.60838 3.71534   1.000 25.05739 ? 44   HIS   A N    1 
ATOM   102  C  CA   . HIS   A 1 39  ? 5.60402   -30.02249 2.67237   1.000 22.67848 ? 44   HIS   A CA   1 
ATOM   103  C  C    . HIS   A 1 39  ? 6.21104   -29.73965 1.30735   1.000 22.70179 ? 44   HIS   A C    1 
ATOM   104  O  O    . HIS   A 1 39  ? 6.94204   -28.75667 1.12125   1.000 24.16022 ? 44   HIS   A O    1 
ATOM   105  C  CB   . HIS   A 1 39  ? 4.25802   -29.29647 2.80627   1.000 21.93651 ? 44   HIS   A CB   1 
ATOM   106  C  CG   . HIS   A 1 39  ? 3.42200   -29.78034 3.95231   1.000 20.71486 ? 44   HIS   A CG   1 
ATOM   107  N  ND1  . HIS   A 1 39  ? 2.81299   -31.01634 3.95843   1.000 21.02506 ? 44   HIS   A ND1  1 
ATOM   108  C  CD2  . HIS   A 1 39  ? 3.08898   -29.18821 5.12324   1.000 19.19497 ? 44   HIS   A CD2  1 
ATOM   109  C  CE1  . HIS   A 1 39  ? 2.14197   -31.16621 5.08844   1.000 24.36605 ? 44   HIS   A CE1  1 
ATOM   110  N  NE2  . HIS   A 1 39  ? 2.29796   -30.07213 5.81632   1.000 22.67505 ? 44   HIS   A NE2  1 
ATOM   111  N  N    . THR   A 1 40  ? 5.90305   -30.60775 0.34144   1.000 20.84516 ? 45   THR   A N    1 
ATOM   112  C  CA   . THR   A 1 40  ? 6.46707   -30.49390 -0.99656  1.000 27.86591 ? 45   THR   A CA   1 
ATOM   113  C  C    . THR   A 1 40  ? 5.47309   -29.97401 -2.02564  1.000 26.41876 ? 45   THR   A C    1 
ATOM   114  O  O    . THR   A 1 40  ? 5.81411   -29.88814 -3.21464  1.000 22.27063 ? 45   THR   A O    1 
ATOM   115  C  CB   . THR   A 1 40  ? 7.02907   -31.84395 -1.44641  1.000 29.88676 ? 45   THR   A CB   1 
ATOM   116  O  OG1  . THR   A 1 40  ? 5.98807   -32.81994 -1.41132  1.000 21.48156 ? 45   THR   A OG1  1 
ATOM   117  C  CG2  . THR   A 1 40  ? 8.17306   -32.27585 -0.50134  1.000 27.63170 ? 45   THR   A CG2  1 
ATOM   118  N  N    . LYS   A 1 41  ? 4.25608   -29.62796 -1.59870  1.000 24.06897 ? 46   LYS   A N    1 
ATOM   119  C  CA   . LYS   A 1 41  ? 3.27710   -28.95005 -2.42979  1.000 24.54276 ? 46   LYS   A CA   1 
ATOM   120  C  C    . LYS   A 1 41  ? 2.60909   -27.87095 -1.58492  1.000 25.00162 ? 46   LYS   A C    1 
ATOM   121  O  O    . LYS   A 1 41  ? 2.97007   -27.65182 -0.42193  1.000 20.89233 ? 46   LYS   A O    1 
ATOM   122  C  CB   . LYS   A 1 41  ? 2.26611   -29.94611 -3.00969  1.000 25.08558 ? 46   LYS   A CB   1 
ATOM   123  C  CG   . LYS   A 1 41  ? 2.92312   -31.00421 -3.91456  1.000 25.95644 ? 46   LYS   A CG   1 
ATOM   124  C  CD   . LYS   A 1 41  ? 1.91213   -31.80430 -4.73749  1.000 29.13948 ? 46   LYS   A CD   1 
ATOM   125  C  CE   . LYS   A 1 41  ? 1.14115   -30.90240 -5.72160  1.000 38.80166 ? 46   LYS   A CE   1 
ATOM   126  N  NZ   . LYS   A 1 41  ? 2.01216   -30.14351 -6.69367  1.000 46.50093 ? 46   LYS   A NZ   1 
ATOM   127  N  N    . ALA   A 1 42  ? 1.64610   -27.17102 -2.19301  1.000 21.35314 ? 47   ALA   A N    1 
ATOM   128  C  CA   . ALA   A 1 42  ? 0.89110   -26.14093 -1.49113  1.000 22.69729 ? 47   ALA   A CA   1 
ATOM   129  C  C    . ALA   A 1 42  ? 0.44207   -26.63478 -0.11909  1.000 18.58424 ? 47   ALA   A C    1 
ATOM   130  O  O    . ALA   A 1 42  ? 0.01207   -27.78176 0.03603   1.000 21.43965 ? 47   ALA   A O    1 
ATOM   131  C  CB   . ALA   A 1 42  ? -0.33089  -25.72802 -2.31620  1.000 21.23118 ? 47   ALA   A CB   1 
ATOM   132  N  N    . VAL   A 1 43  ? 0.53406   -25.75767 0.87182   1.000 20.33323 ? 48   VAL   A N    1 
ATOM   133  C  CA   . VAL   A 1 43  ? -0.00196  -26.03552 2.20384   1.000 17.68316 ? 48   VAL   A CA   1 
ATOM   134  C  C    . VAL   A 1 43  ? -1.41496  -25.46851 2.27575   1.000 23.25232 ? 48   VAL   A C    1 
ATOM   135  O  O    . VAL   A 1 43  ? -1.62195  -24.27053 2.06562   1.000 24.31959 ? 48   VAL   A O    1 
ATOM   136  C  CB   . VAL   A 1 43  ? 0.89402   -25.44241 3.29279   1.000 21.55736 ? 48   VAL   A CB   1 
ATOM   137  C  CG1  . VAL   A 1 43  ? 0.28800   -25.70225 4.65681   1.000 19.43251 ? 48   VAL   A CG1  1 
ATOM   138  C  CG2  . VAL   A 1 43  ? 2.30002   -26.04742 3.17888   1.000 24.26035 ? 48   VAL   A CG2  1 
ATOM   139  N  N    . SER   A 1 44  ? -2.39097  -26.33148 2.55183   1.000 18.54698 ? 49   SER   A N    1 
ATOM   140  C  CA   . SER   A 1 44  ? -3.78797  -25.92948 2.43377   1.000 18.98533 ? 49   SER   A CA   1 
ATOM   141  C  C    . SER   A 1 44  ? -4.38098  -25.42434 3.74170   1.000 21.59047 ? 49   SER   A C    1 
ATOM   142  O  O    . SER   A 1 44  ? -5.23998  -24.53634 3.71859   1.000 22.83932 ? 49   SER   A O    1 
ATOM   143  C  CB   . SER   A 1 44  ? -4.62796  -27.10654 1.92088   1.000 25.91315 ? 49   SER   A CB   1 
ATOM   144  O  OG   . SER   A 1 44  ? -4.50898  -28.22244 2.80501   1.000 23.63161 ? 49   SER   A OG   1 
ATOM   145  N  N    . SER   A 1 45  ? -3.95300  -25.93721 4.89177   1.000 20.98264 ? 50   SER   A N    1 
ATOM   146  C  CA   . SER   A 1 45  ? -4.64202  -25.58107 6.12572   1.000 22.81672 ? 50   SER   A CA   1 
ATOM   147  C  C    . SER   A 1 45  ? -3.70604  -25.78195 7.31275   1.000 24.56705 ? 50   SER   A C    1 
ATOM   148  O  O    . SER   A 1 45  ? -3.00805  -26.79694 7.38288   1.000 22.88569 ? 50   SER   A O    1 
ATOM   149  C  CB   . SER   A 1 45  ? -5.91803  -26.42305 6.28479   1.000 18.12373 ? 50   SER   A CB   1 
ATOM   150  O  OG   . SER   A 1 45  ? -6.77704  -25.88594 7.28672   1.000 22.32282 ? 50   SER   A OG   1 
ATOM   151  N  N    . VAL   A 1 46  ? -3.70305  -24.81884 8.23565   1.000 18.15489 ? 51   VAL   A N    1 
ATOM   152  C  CA   . VAL   A 1 46  ? -2.97507  -24.93671 9.49467   1.000 18.22708 ? 51   VAL   A CA   1 
ATOM   153  C  C    . VAL   A 1 46  ? -3.95309  -24.67658 10.63163  1.000 21.91581 ? 51   VAL   A C    1 
ATOM   154  O  O    . VAL   A 1 46  ? -4.77609  -23.75458 10.55451  1.000 20.68726 ? 51   VAL   A O    1 
ATOM   155  C  CB   . VAL   A 1 46  ? -1.75707  -23.97970 9.58159   1.000 21.13305 ? 51   VAL   A CB   1 
ATOM   156  C  CG1  . VAL   A 1 46  ? -0.62306  -24.45381 8.67166   1.000 21.66108 ? 51   VAL   A CG1  1 
ATOM   157  C  CG2  . VAL   A 1 46  ? -2.14106  -22.54074 9.24542   1.000 20.36708 ? 51   VAL   A CG2  1 
ATOM   158  N  N    . LYS   A 1 47  ? -3.86111  -25.49346 11.68572  1.000 20.01232 ? 52   LYS   A N    1 
ATOM   159  C  CA   . LYS   A 1 47  ? -4.76013  -25.41033 12.83470  1.000 21.15639 ? 52   LYS   A CA   1 
ATOM   160  C  C    . LYS   A 1 47  ? -3.97815  -25.66819 14.11474  1.000 22.14055 ? 52   LYS   A C    1 
ATOM   161  O  O    . LYS   A 1 47  ? -3.22616  -26.64319 14.19686  1.000 25.23989 ? 52   LYS   A O    1 
ATOM   162  C  CB   . LYS   A 1 47  ? -5.89713  -26.43434 12.72779  1.000 21.12622 ? 52   LYS   A CB   1 
ATOM   163  C  CG   . LYS   A 1 47  ? -6.77111  -26.32947 11.47376  1.000 19.83496 ? 52   LYS   A CG   1 
ATOM   164  C  CD   . LYS   A 1 47  ? -7.76211  -25.16446 11.55262  1.000 19.79867 ? 52   LYS   A CD   1 
ATOM   165  C  CE   . LYS   A 1 47  ? -8.59209  -25.05460 10.27259  1.000 20.78565 ? 52   LYS   A CE   1 
ATOM   166  N  NZ   . LYS   A 1 47  ? -9.47509  -26.25062 10.04371  1.000 21.47637 ? 52   LYS   A NZ   1 
ATOM   167  N  N    . PHE   A 1 48  ? -4.16016  -24.80708 15.10564  1.000 20.71724 ? 53   PHE   A N    1 
ATOM   168  C  CA   . PHE   A 1 48  ? -3.57119  -25.03894 16.41867  1.000 25.88082 ? 53   PHE   A CA   1 
ATOM   169  C  C    . PHE   A 1 48  ? -4.42320  -26.02685 17.19477  1.000 27.86200 ? 53   PHE   A C    1 
ATOM   170  O  O    . PHE   A 1 48  ? -5.65220  -25.95185 17.17074  1.000 22.53489 ? 53   PHE   A O    1 
ATOM   171  C  CB   . PHE   A 1 48  ? -3.47119  -23.72985 17.20953  1.000 21.37422 ? 53   PHE   A CB   1 
ATOM   172  C  CG   . PHE   A 1 48  ? -2.38618  -22.82391 16.73945  1.000 23.08472 ? 53   PHE   A CG   1 
ATOM   173  C  CD1  . PHE   A 1 48  ? -1.04719  -23.14489 16.97450  1.000 23.63527 ? 53   PHE   A CD1  1 
ATOM   174  C  CD2  . PHE   A 1 48  ? -2.68317  -21.64998 16.06831  1.000 20.34851 ? 53   PHE   A CD2  1 
ATOM   175  C  CE1  . PHE   A 1 48  ? -0.03518  -22.31594 16.53343  1.000 23.20492 ? 53   PHE   A CE1  1 
ATOM   176  C  CE2  . PHE   A 1 48  ? -1.67016  -20.80203 15.63124  1.000 26.16071 ? 53   PHE   A CE2  1 
ATOM   177  C  CZ   . PHE   A 1 48  ? -0.34316  -21.13601 15.86629  1.000 22.99695 ? 53   PHE   A CZ   1 
ATOM   178  N  N    . SER   A 1 49  ? -3.77522  -26.95478 17.88788  1.000 24.63292 ? 54   SER   A N    1 
ATOM   179  C  CA   . SER   A 1 49  ? -4.54323  -27.81668 18.76696  1.000 26.41677 ? 54   SER   A CA   1 
ATOM   180  C  C    . SER   A 1 49  ? -5.21525  -26.96056 19.83986  1.000 23.36399 ? 54   SER   A C    1 
ATOM   181  O  O    . SER   A 1 49  ? -4.66625  -25.93351 20.26075  1.000 23.33873 ? 54   SER   A O    1 
ATOM   182  C  CB   . SER   A 1 49  ? -3.65025  -28.88961 19.40010  1.000 25.93000 ? 54   SER   A CB   1 
ATOM   183  O  OG   . SER   A 1 49  ? -2.59526  -28.31153 20.14905  1.000 23.38473 ? 54   SER   A OG   1 
ATOM   184  N  N    . PRO   A 1 50  ? -6.42526  -27.33350 20.27088  1.000 25.02775 ? 55   PRO   A N    1 
ATOM   185  C  CA   . PRO   A 1 50  ? -7.08927  -26.55938 21.33879  1.000 27.54848 ? 55   PRO   A CA   1 
ATOM   186  C  C    . PRO   A 1 50  ? -6.26729  -26.44125 22.61479  1.000 29.43633 ? 55   PRO   A C    1 
ATOM   187  O  O    . PRO   A 1 50  ? -6.37730  -25.41717 23.30667  1.000 25.91641 ? 55   PRO   A O    1 
ATOM   188  C  CB   . PRO   A 1 50  ? -8.39828  -27.33235 21.57185  1.000 28.00771 ? 55   PRO   A CB   1 
ATOM   189  C  CG   . PRO   A 1 50  ? -8.66026  -28.01650 20.24292  1.000 29.91670 ? 55   PRO   A CG   1 
ATOM   190  C  CD   . PRO   A 1 50  ? -7.29525  -28.39256 19.72098  1.000 24.06892 ? 55   PRO   A CD   1 
ATOM   191  N  N    . ASN   A 1 51  ? -5.45030  -27.44121 22.96191  1.000 26.96135 ? 56   ASN   A N    1 
ATOM   192  C  CA   . ASN   A 1 51  ? -4.60032  -27.28808 24.14091  1.000 32.62850 ? 56   ASN   A CA   1 
ATOM   193  C  C    . ASN   A 1 51  ? -3.34331  -26.46412 23.86683  1.000 33.22021 ? 56   ASN   A C    1 
ATOM   194  O  O    . ASN   A 1 51  ? -2.49832  -26.33602 24.76083  1.000 31.85556 ? 56   ASN   A O    1 
ATOM   195  C  CB   . ASN   A 1 51  ? -4.22033  -28.65502 24.72806  1.000 28.12034 ? 56   ASN   A CB   1 
ATOM   196  C  CG   . ASN   A 1 51  ? -3.27232  -29.44712 23.84116  1.000 32.26387 ? 56   ASN   A CG   1 
ATOM   197  O  OD1  . ASN   A 1 51  ? -2.68630  -28.92423 22.89412  1.000 30.86730 ? 56   ASN   A OD1  1 
ATOM   198  N  ND2  . ASN   A 1 51  ? -3.11433  -30.72409 24.15431  1.000 32.41994 ? 56   ASN   A ND2  1 
ATOM   199  N  N    . GLY   A 1 52  ? -3.19829  -25.89525 22.67377  1.000 25.32714 ? 57   GLY   A N    1 
ATOM   200  C  CA   . GLY   A 1 52  ? -2.15128  -24.92928 22.42968  1.000 25.82717 ? 57   GLY   A CA   1 
ATOM   201  C  C    . GLY   A 1 52  ? -0.76828  -25.49631 22.18577  1.000 28.10927 ? 57   GLY   A C    1 
ATOM   202  O  O    . GLY   A 1 52  ? 0.15873   -24.72235 21.89770  1.000 27.84104 ? 57   GLY   A O    1 
ATOM   203  N  N    . GLU   A 1 53  ? -0.59828  -26.81431 22.26692  1.000 27.83398 ? 58   GLU   A N    1 
ATOM   204  C  CA   . GLU   A 1 53  ? 0.72771   -27.41432 22.16000  1.000 25.63074 ? 58   GLU   A CA   1 
ATOM   205  C  C    . GLU   A 1 53  ? 1.18874   -27.60148 20.71703  1.000 27.19582 ? 58   GLU   A C    1 
ATOM   206  O  O    . GLU   A 1 53  ? 2.39574   -27.55852 20.45305  1.000 23.70231 ? 58   GLU   A O    1 
ATOM   207  C  CB   . GLU   A 1 53  ? 0.74570   -28.76924 22.86515  1.000 26.93387 ? 58   GLU   A CB   1 
ATOM   208  C  CG   . GLU   A 1 53  ? 0.58467   -28.67908 24.37914  1.000 39.37627 ? 58   GLU   A CG   1 
ATOM   209  C  CD   . GLU   A 1 53  ? 1.69567   -27.88901 25.04507  1.000 40.88178 ? 58   GLU   A CD   1 
ATOM   210  O  OE1  . GLU   A 1 53  ? 2.87167   -28.28903 24.91413  1.000 46.14944 ? 58   GLU   A OE1  1 
ATOM   211  O  OE2  . GLU   A 1 53  ? 1.38566   -26.86494 25.68695  1.000 45.63238 ? 58   GLU   A OE2  1 
ATOM   212  N  N    . TRP   A 1 54  ? 0.26375   -27.82858 19.78104  1.000 25.04741 ? 59   TRP   A N    1 
ATOM   213  C  CA   . TRP   A 1 54  ? 0.61877   -28.31573 18.45510  1.000 24.56714 ? 59   TRP   A CA   1 
ATOM   214  C  C    . TRP   A 1 54  ? -0.00221  -27.46585 17.35500  1.000 23.83349 ? 59   TRP   A C    1 
ATOM   215  O  O    . TRP   A 1 54  ? -1.06121  -26.84883 17.52391  1.000 23.09604 ? 59   TRP   A O    1 
ATOM   216  C  CB   . TRP   A 1 54  ? 0.16477   -29.78075 18.26926  1.000 27.20530 ? 59   TRP   A CB   1 
ATOM   217  C  CG   . TRP   A 1 54  ? 0.69975   -30.66563 19.33836  1.000 26.78643 ? 59   TRP   A CG   1 
ATOM   218  C  CD1  . TRP   A 1 54  ? 0.00473   -31.23152 20.37641  1.000 33.48820 ? 59   TRP   A CD1  1 
ATOM   219  C  CD2  . TRP   A 1 54  ? 2.06474   -31.04562 19.51143  1.000 28.89637 ? 59   TRP   A CD2  1 
ATOM   220  N  NE1  . TRP   A 1 54  ? 0.86171   -31.95943 21.17351  1.000 33.25791 ? 59   TRP   A NE1  1 
ATOM   221  C  CE2  . TRP   A 1 54  ? 2.13272   -31.85549 20.66552  1.000 37.63137 ? 59   TRP   A CE2  1 
ATOM   222  C  CE3  . TRP   A 1 54  ? 3.24176   -30.78170 18.79742  1.000 28.35886 ? 59   TRP   A CE3  1 
ATOM   223  C  CZ2  . TRP   A 1 54  ? 3.32571   -32.40945 21.11460  1.000 38.74046 ? 59   TRP   A CZ2  1 
ATOM   224  C  CZ3  . TRP   A 1 54  ? 4.43075   -31.32966 19.24950  1.000 38.99866 ? 59   TRP   A CZ3  1 
ATOM   225  C  CH2  . TRP   A 1 54  ? 4.46373   -32.13853 20.39659  1.000 39.61744 ? 59   TRP   A CH2  1 
ATOM   226  N  N    . LEU   A 1 55  ? 0.67381   -27.46698 16.21301  1.000 22.63738 ? 60   LEU   A N    1 
ATOM   227  C  CA   . LEU   A 1 55  ? 0.12683   -27.00812 14.95095  1.000 21.91533 ? 60   LEU   A CA   1 
ATOM   228  C  C    . LEU   A 1 55  ? 0.01984   -28.20822 14.02008  1.000 23.40676 ? 60   LEU   A C    1 
ATOM   229  O  O    . LEU   A 1 55  ? 0.96684   -28.98823 13.90318  1.000 23.03095 ? 60   LEU   A O    1 
ATOM   230  C  CB   . LEU   A 1 55  ? 1.01284   -25.93119 14.31984  1.000 22.95561 ? 60   LEU   A CB   1 
ATOM   231  C  CG   . LEU   A 1 55  ? 0.36987   -25.24532 13.10476  1.000 22.45019 ? 60   LEU   A CG   1 
ATOM   232  C  CD1  . LEU   A 1 55  ? -0.67414  -24.24526 13.58363  1.000 20.36838 ? 60   LEU   A CD1  1 
ATOM   233  C  CD2  . LEU   A 1 55  ? 1.41688   -24.55842 12.26370  1.000 26.14582 ? 60   LEU   A CD2  1 
ATOM   234  N  N    . ALA   A 1 56  ? -1.14615  -28.38428 13.40408  1.000 20.53573 ? 61   ALA   A N    1 
ATOM   235  C  CA   . ALA   A 1 56  ? -1.32914  -29.38840 12.37119  1.000 22.83601 ? 61   ALA   A CA   1 
ATOM   236  C  C    . ALA   A 1 56  ? -1.41211  -28.68754 11.02511  1.000 23.27651 ? 61   ALA   A C    1 
ATOM   237  O  O    . ALA   A 1 56  ? -2.01211  -27.61355 10.91398  1.000 21.93416 ? 61   ALA   A O    1 
ATOM   238  C  CB   . ALA   A 1 56  ? -2.59814  -30.20936 12.61526  1.000 25.35446 ? 61   ALA   A CB   1 
ATOM   239  N  N    . SER   A 1 57  ? -0.80510  -29.28266 10.00719  1.000 22.25986 ? 62   SER   A N    1 
ATOM   240  C  CA   . SER   A 1 57  ? -0.88708  -28.73681 8.66112   1.000 18.02229 ? 62   SER   A CA   1 
ATOM   241  C  C    . SER   A 1 57  ? -1.27206  -29.84491 7.68524   1.000 24.01361 ? 62   SER   A C    1 
ATOM   242  O  O    . SER   A 1 57  ? -0.86107  -30.99790 7.84637   1.000 23.97457 ? 62   SER   A O    1 
ATOM   243  C  CB   . SER   A 1 57  ? 0.44593   -28.08586 8.23607   1.000 21.92819 ? 62   SER   A CB   1 
ATOM   244  O  OG   . SER   A 1 57  ? 1.51993   -29.01785 8.31419   1.000 20.48648 ? 62   SER   A OG   1 
ATOM   245  N  N    . SER   A 1 58  ? -2.05805  -29.48302 6.67219   1.000 23.11530 ? 63   SER   A N    1 
ATOM   246  C  CA   . SER   A 1 58  ? -2.40503  -30.37314 5.57928   1.000 19.45137 ? 63   SER   A CA   1 
ATOM   247  C  C    . SER   A 1 58  ? -1.88301  -29.77029 4.27822   1.000 22.09382 ? 63   SER   A C    1 
ATOM   248  O  O    . SER   A 1 58  ? -1.63100  -28.56330 4.18809   1.000 20.49647 ? 63   SER   A O    1 
ATOM   249  C  CB   . SER   A 1 58  ? -3.93103  -30.59614 5.50128   1.000 23.20480 ? 63   SER   A CB   1 
ATOM   250  O  OG   . SER   A 1 58  ? -4.64703  -29.36816 5.37413   1.000 22.37942 ? 63   SER   A OG   1 
ATOM   251  N  N    . SER   A 1 59  ? -1.72200  -30.60940 3.25932   1.000 19.54064 ? 64   SER   A N    1 
ATOM   252  C  CA   . SER   A 1 59  ? -1.07098  -30.13654 2.04928   1.000 22.99808 ? 64   SER   A CA   1 
ATOM   253  C  C    . SER   A 1 59  ? -1.58896  -30.89167 0.83635   1.000 21.48610 ? 64   SER   A C    1 
ATOM   254  O  O    . SER   A 1 59  ? -2.06696  -32.02966 0.92547   1.000 21.07713 ? 64   SER   A O    1 
ATOM   255  C  CB   . SER   A 1 59  ? 0.46302   -30.27853 2.15032   1.000 22.16005 ? 64   SER   A CB   1 
ATOM   256  O  OG   . SER   A 1 59  ? 1.09404   -30.05867 0.89630   1.000 21.09027 ? 64   SER   A OG   1 
ATOM   257  N  N    . ALA   A 1 60  ? -1.46194  -30.23580 -0.31472  1.000 22.77074 ? 65   ALA   A N    1 
ATOM   258  C  CA   . ALA   A 1 60  ? -1.64392  -30.92294 -1.58165  1.000 22.74132 ? 65   ALA   A CA   1 
ATOM   259  C  C    . ALA   A 1 60  ? -0.69692  -32.11196 -1.73150  1.000 26.51994 ? 65   ALA   A C    1 
ATOM   260  O  O    . ALA   A 1 60  ? -0.92791  -32.96905 -2.59241  1.000 24.56996 ? 65   ALA   A O    1 
ATOM   261  C  CB   . ALA   A 1 60  ? -1.45090  -29.93706 -2.73675  1.000 20.91715 ? 65   ALA   A CB   1 
ATOM   262  N  N    . ASP   A 1 61  ? 0.34906   -32.20287 -0.91447  1.000 23.77567 ? 66   ASP   A N    1 
ATOM   263  C  CA   . ASP   A 1 61  ? 1.25206   -33.34489 -1.02833  1.000 25.65904 ? 66   ASP   A CA   1 
ATOM   264  C  C    . ASP   A 1 61  ? 0.69905   -34.59481 -0.36920  1.000 28.69507 ? 66   ASP   A C    1 
ATOM   265  O  O    . ASP   A 1 61  ? 1.43104   -35.57180 -0.24508  1.000 25.82031 ? 66   ASP   A O    1 
ATOM   266  C  CB   . ASP   A 1 61  ? 2.63405   -33.00683 -0.45535  1.000 23.62947 ? 66   ASP   A CB   1 
ATOM   267  C  CG   . ASP   A 1 61  ? 2.63303   -32.83866 1.04763   1.000 25.68471 ? 66   ASP   A CG   1 
ATOM   268  O  OD1  . ASP   A 1 61  ? 1.61502   -33.13458 1.70865   1.000 23.74738 ? 66   ASP   A OD1  1 
ATOM   269  O  OD2  . ASP   A 1 61  ? 3.68002   -32.41161 1.57560   1.000 24.26169 ? 66   ASP   A OD2  1 
ATOM   270  N  N    . LYS   A 1 62  ? -0.57696  -34.58976 0.02578   1.000 22.80430 ? 67   LYS   A N    1 
ATOM   271  C  CA   . LYS   A 1 62  ? -1.29997  -35.72270 0.59889   1.000 23.92536 ? 67   LYS   A CA   1 
ATOM   272  C  C    . LYS   A 1 62  ? -0.92800  -35.98254 2.04992   1.000 25.00988 ? 67   LYS   A C    1 
ATOM   273  O  O    . LYS   A 1 62  ? -1.33601  -37.01348 2.59603   1.000 24.64079 ? 67   LYS   A O    1 
ATOM   274  C  CB   . LYS   A 1 62  ? -1.07197  -37.03178 -0.16396  1.000 28.50712 ? 67   LYS   A CB   1 
ATOM   275  C  CG   . LYS   A 1 62  ? -1.28194  -36.95994 -1.64997  1.000 27.14953 ? 67   LYS   A CG   1 
ATOM   276  C  CD   . LYS   A 1 62  ? -0.84094  -38.27002 -2.28182  1.000 30.75374 ? 67   LYS   A CD   1 
ATOM   277  C  CE   . LYS   A 1 62  ? -0.86591  -38.20618 -3.79083  1.000 45.41266 ? 67   LYS   A CE   1 
ATOM   278  N  NZ   . LYS   A 1 62  ? -0.31091  -39.46025 -4.36968  1.000 59.60616 ? 67   LYS   A NZ   1 
ATOM   279  N  N    . LEU   A 1 63  ? -0.18700  -35.09147 2.69584   1.000 25.28997 ? 68   LEU   A N    1 
ATOM   280  C  CA   . LEU   A 1 63  ? 0.35997   -35.35832 4.01488   1.000 25.81108 ? 68   LEU   A CA   1 
ATOM   281  C  C    . LEU   A 1 63  ? -0.20104  -34.39121 5.03776   1.000 26.75627 ? 68   LEU   A C    1 
ATOM   282  O  O    . LEU   A 1 63  ? -0.49703  -33.23724 4.72763   1.000 24.93547 ? 68   LEU   A O    1 
ATOM   283  C  CB   . LEU   A 1 63  ? 1.87897   -35.23833 4.01689   1.000 24.69705 ? 68   LEU   A CB   1 
ATOM   284  C  CG   . LEU   A 1 63  ? 2.62199   -36.20243 3.10600   1.000 27.15692 ? 68   LEU   A CG   1 
ATOM   285  C  CD1  . LEU   A 1 63  ? 4.10998   -35.96142 3.27000   1.000 26.44306 ? 68   LEU   A CD1  1 
ATOM   286  C  CD2  . LEU   A 1 63  ? 2.25497   -37.63639 3.46116   1.000 30.02890 ? 68   LEU   A CD2  1 
ATOM   287  N  N    . ILE   A 1 64  ? -0.31906  -34.87807 6.26681   1.000 22.06093 ? 69   ILE   A N    1 
ATOM   288  C  CA   . ILE   A 1 64  ? -0.56008  -34.05894 7.44072   1.000 20.69145 ? 69   ILE   A CA   1 
ATOM   289  C  C    . ILE   A 1 64  ? 0.73791   -34.01086 8.22473   1.000 25.02348 ? 69   ILE   A C    1 
ATOM   290  O  O    . ILE   A 1 64  ? 1.41691   -35.03485 8.36786   1.000 26.17773 ? 69   ILE   A O    1 
ATOM   291  C  CB   . ILE   A 1 64  ? -1.70009  -34.63684 8.30076   1.000 23.05852 ? 69   ILE   A CB   1 
ATOM   292  C  CG1  . ILE   A 1 64  ? -3.03108  -34.53092 7.54973   1.000 27.80819 ? 69   ILE   A CG1  1 
ATOM   293  C  CG2  . ILE   A 1 64  ? -1.73611  -33.95269 9.66869   1.000 20.02768 ? 69   ILE   A CG2  1 
ATOM   294  C  CD1  . ILE   A 1 64  ? -4.13209  -35.39385 8.12081   1.000 27.19867 ? 69   ILE   A CD1  1 
ATOM   295  N  N    . LYS   A 1 65  ? 1.09391   -32.83581 8.72361   1.000 21.79659 ? 70   LYS   A N    1 
ATOM   296  C  CA   . LYS   A 1 65  ? 2.28490   -32.71272 9.55261   1.000 22.18002 ? 70   LYS   A CA   1 
ATOM   297  C  C    . LYS   A 1 65  ? 1.92788   -32.00358 10.84353  1.000 28.78755 ? 70   LYS   A C    1 
ATOM   298  O  O    . LYS   A 1 65  ? 1.06988   -31.11257 10.86342  1.000 25.52164 ? 70   LYS   A O    1 
ATOM   299  C  CB   . LYS   A 1 65  ? 3.42491   -31.97980 8.83355   1.000 22.88764 ? 70   LYS   A CB   1 
ATOM   300  C  CG   . LYS   A 1 65  ? 4.03992   -32.81893 7.71065   1.000 25.39297 ? 70   LYS   A CG   1 
ATOM   301  C  CD   . LYS   A 1 65  ? 5.12894   -32.06602 6.94559   1.000 27.93921 ? 70   LYS   A CD   1 
ATOM   302  C  CE   . LYS   A 1 65  ? 5.64195   -32.91515 5.78369   1.000 23.77304 ? 70   LYS   A CE   1 
ATOM   303  N  NZ   . LYS   A 1 65  ? 6.52594   -34.04610 6.24583   1.000 24.49200 ? 70   LYS   A NZ   1 
ATOM   304  N  N    . ILE   A 1 66  ? 2.56586   -32.44346 11.91959  1.000 23.93295 ? 71   ILE   A N    1 
ATOM   305  C  CA   . ILE   A 1 66  ? 2.37384   -31.90231 13.25453  1.000 21.13337 ? 71   ILE   A CA   1 
ATOM   306  C  C    . ILE   A 1 66  ? 3.65484   -31.18127 13.64147  1.000 24.19841 ? 71   ILE   A C    1 
ATOM   307  O  O    . ILE   A 1 66  ? 4.75184   -31.70630 13.43354  1.000 26.97575 ? 71   ILE   A O    1 
ATOM   308  C  CB   . ILE   A 1 66  ? 2.05282   -33.02720 14.25764  1.000 24.32423 ? 71   ILE   A CB   1 
ATOM   309  C  CG1  . ILE   A 1 66  ? 0.89182   -33.88725 13.75372  1.000 27.46579 ? 71   ILE   A CG1  1 
ATOM   310  C  CG2  . ILE   A 1 66  ? 1.73180   -32.44005 15.62357  1.000 26.10017 ? 71   ILE   A CG2  1 
ATOM   311  C  CD1  . ILE   A 1 66  ? -0.45017  -33.18424 13.82862  1.000 25.04542 ? 71   ILE   A CD1  1 
ATOM   312  N  N    . TRP   A 1 67  ? 3.51483   -29.99121 14.21133  1.000 25.95428 ? 72   TRP   A N    1 
ATOM   313  C  CA   . TRP   A 1 67  ? 4.64483   -29.15117 14.57826  1.000 23.79058 ? 72   TRP   A CA   1 
ATOM   314  C  C    . TRP   A 1 67  ? 4.42181   -28.60002 15.97519  1.000 23.12851 ? 72   TRP   A C    1 
ATOM   315  O  O    . TRP   A 1 67  ? 3.28380   -28.38897 16.39215  1.000 23.47435 ? 72   TRP   A O    1 
ATOM   316  C  CB   . TRP   A 1 67  ? 4.83285   -27.96428 13.62013  1.000 24.79556 ? 72   TRP   A CB   1 
ATOM   317  C  CG   . TRP   A 1 67  ? 4.61487   -28.27344 12.18216  1.000 23.16281 ? 72   TRP   A CG   1 
ATOM   318  C  CD1  . TRP   A 1 67  ? 3.41788   -28.50550 11.56717  1.000 24.17720 ? 72   TRP   A CD1  1 
ATOM   319  C  CD2  . TRP   A 1 67  ? 5.61589   -28.35856 11.15619  1.000 25.02063 ? 72   TRP   A CD2  1 
ATOM   320  N  NE1  . TRP   A 1 67  ? 3.60690   -28.74765 10.22720  1.000 22.73413 ? 72   TRP   A NE1  1 
ATOM   321  C  CE2  . TRP   A 1 67  ? 4.94590   -28.66469 9.94421   1.000 24.75177 ? 72   TRP   A CE2  1 
ATOM   322  C  CE3  . TRP   A 1 67  ? 7.01189   -28.22056 11.14319  1.000 25.74334 ? 72   TRP   A CE3  1 
ATOM   323  C  CZ2  . TRP   A 1 67  ? 5.62392   -28.82782 8.73124   1.000 23.89507 ? 72   TRP   A CZ2  1 
ATOM   324  C  CZ3  . TRP   A 1 67  ? 7.68791   -28.38670 9.93622   1.000 27.31030 ? 72   TRP   A CZ3  1 
ATOM   325  C  CH2  . TRP   A 1 67  ? 6.99192   -28.67583 8.74524   1.000 24.93269 ? 72   TRP   A CH2  1 
ATOM   326  N  N    . GLY   A 1 68  ? 5.51880   -28.34694 16.68418  1.000 27.16428 ? 73   GLY   A N    1 
ATOM   327  C  CA   . GLY   A 1 68  ? 5.42778   -27.68280 17.97311  1.000 23.76333 ? 73   GLY   A CA   1 
ATOM   328  C  C    . GLY   A 1 68  ? 4.95279   -26.25482 17.79894  1.000 26.76790 ? 73   GLY   A C    1 
ATOM   329  O  O    . GLY   A 1 68  ? 5.49280   -25.50591 16.97787  1.000 23.71198 ? 73   GLY   A O    1 
ATOM   330  N  N    . ALA   A 1 69  ? 3.93278   -25.86573 18.57588  1.000 24.97156 ? 74   ALA   A N    1 
ATOM   331  C  CA   . ALA   A 1 69  ? 3.29579   -24.56975 18.34373  1.000 24.68212 ? 74   ALA   A CA   1 
ATOM   332  C  C    . ALA   A 1 69  ? 4.16378   -23.41970 18.81962  1.000 28.88231 ? 74   ALA   A C    1 
ATOM   333  O  O    . ALA   A 1 69  ? 4.06080   -22.30676 18.28949  1.000 24.59141 ? 74   ALA   A O    1 
ATOM   334  C  CB   . ALA   A 1 69  ? 1.92878   -24.50867 19.02570  1.000 26.48130 ? 74   ALA   A CB   1 
ATOM   335  N  N    . TYR   A 1 70  ? 5.03177   -23.66260 19.80666  1.000 25.00389 ? 75   TYR   A N    1 
ATOM   336  C  CA   . TYR   A 1 70  ? 5.85576   -22.60454 20.36655  1.000 28.88572 ? 75   TYR   A CA   1 
ATOM   337  C  C    . TYR   A 1 70  ? 7.24777   -22.56461 19.76957  1.000 28.40837 ? 75   TYR   A C    1 
ATOM   338  O  O    . TYR   A 1 70  ? 7.81178   -21.47963 19.63446  1.000 33.54999 ? 75   TYR   A O    1 
ATOM   339  C  CB   . TYR   A 1 70  ? 5.95074   -22.75237 21.89157  1.000 26.40383 ? 75   TYR   A CB   1 
ATOM   340  C  CG   . TYR   A 1 70  ? 4.59173   -22.76430 22.52755  1.000 28.76498 ? 75   TYR   A CG   1 
ATOM   341  C  CD1  . TYR   A 1 70  ? 3.83173   -21.60328 22.61141  1.000 31.70060 ? 75   TYR   A CD1  1 
ATOM   342  C  CD2  . TYR   A 1 70  ? 4.04771   -23.94124 23.02167  1.000 29.52289 ? 75   TYR   A CD2  1 
ATOM   343  C  CE1  . TYR   A 1 70  ? 2.56572   -21.61822 23.18839  1.000 30.25527 ? 75   TYR   A CE1  1 
ATOM   344  C  CE2  . TYR   A 1 70  ? 2.77970   -23.96817 23.60066  1.000 27.61540 ? 75   TYR   A CE2  1 
ATOM   345  C  CZ   . TYR   A 1 70  ? 2.04671   -22.80416 23.68252  1.000 32.71715 ? 75   TYR   A CZ   1 
ATOM   346  O  OH   . TYR   A 1 70  ? 0.79070   -22.82909 24.26050  1.000 36.79838 ? 75   TYR   A OH   1 
ATOM   347  N  N    . ASP   A 1 71  ? 7.80377   -23.70766 19.38271  1.000 24.61360 ? 76   ASP   A N    1 
ATOM   348  C  CA   . ASP   A 1 71  ? 9.14378   -23.74672 18.81873  1.000 25.86746 ? 76   ASP   A CA   1 
ATOM   349  C  C    . ASP   A 1 71  ? 9.15980   -24.05989 17.33377  1.000 31.40979 ? 76   ASP   A C    1 
ATOM   350  O  O    . ASP   A 1 71  ? 10.23681  -24.05996 16.73478  1.000 26.67244 ? 76   ASP   A O    1 
ATOM   351  C  CB   . ASP   A 1 71  ? 10.00877  -24.76264 19.57886  1.000 27.41387 ? 76   ASP   A CB   1 
ATOM   352  C  CG   . ASP   A 1 71  ? 9.47276   -26.17965 19.50501  1.000 34.82208 ? 76   ASP   A CG   1 
ATOM   353  O  OD1  . ASP   A 1 71  ? 8.54377   -26.44873 18.70902  1.000 33.33308 ? 76   ASP   A OD1  1 
ATOM   354  O  OD2  . ASP   A 1 71  ? 9.98975   -27.03657 20.25311  1.000 36.03912 ? 76   ASP   A OD2  1 
ATOM   355  N  N    . GLY   A 1 72  ? 8.00281   -24.32495 16.72378  1.000 28.05955 ? 77   GLY   A N    1 
ATOM   356  C  CA   . GLY   A 1 72  ? 7.97583   -24.64711 15.31181  1.000 28.78611 ? 77   GLY   A CA   1 
ATOM   357  C  C    . GLY   A 1 72  ? 8.69784   -25.92415 14.94097  1.000 34.45266 ? 77   GLY   A C    1 
ATOM   358  O  O    . GLY   A 1 72  ? 8.99085   -26.13928 13.76299  1.000 27.08578 ? 77   GLY   A O    1 
ATOM   359  N  N    . LYS   A 1 73  ? 8.97782   -26.79404 15.90807  1.000 31.09449 ? 78   LYS   A N    1 
ATOM   360  C  CA   . LYS   A 1 73  ? 9.79182   -27.97708 15.64621  1.000 30.06434 ? 78   LYS   A CA   1 
ATOM   361  C  C    . LYS   A 1 73  ? 8.93282   -29.07714 15.04232  1.000 28.94832 ? 78   LYS   A C    1 
ATOM   362  O  O    . LYS   A 1 73  ? 7.87181   -29.40508 15.58234  1.000 27.60620 ? 78   LYS   A O    1 
ATOM   363  C  CB   . LYS   A 1 73  ? 10.45179  -28.46993 16.94128  1.000 33.48079 ? 78   LYS   A CB   1 
ATOM   364  C  CG   . LYS   A 1 73  ? 11.37179  -29.68596 16.78242  1.000 41.32108 ? 78   LYS   A CG   1 
ATOM   365  C  CD   . LYS   A 1 73  ? 11.97077  -30.15681 18.12849  1.000 35.67247 ? 78   LYS   A CD   1 
ATOM   366  C  CE   . LYS   A 1 73  ? 11.01375  -31.09372 18.87957  1.000 48.43278 ? 78   LYS   A CE   1 
ATOM   367  N  NZ   . LYS   A 1 73  ? 11.68173  -31.89461 19.96167  1.000 62.84585 ? 78   LYS   A NZ   1 
ATOM   368  N  N    . PHE   A 1 74  ? 9.38884   -29.64626 13.92539  1.000 23.71067 ? 79   PHE   A N    1 
ATOM   369  C  CA   . PHE   A 1 74  ? 8.66384   -30.74833 13.30550  1.000 28.24775 ? 79   PHE   A CA   1 
ATOM   370  C  C    . PHE   A 1 74  ? 8.50582   -31.89822 14.29062  1.000 35.22709 ? 79   PHE   A C    1 
ATOM   371  O  O    . PHE   A 1 74  ? 9.42081   -32.22414 15.05067  1.000 30.89716 ? 79   PHE   A O    1 
ATOM   372  C  CB   . PHE   A 1 74  ? 9.38486   -31.23047 12.04356  1.000 29.27903 ? 79   PHE   A CB   1 
ATOM   373  C  CG   . PHE   A 1 74  ? 8.83587   -32.51253 11.47870  1.000 28.76601 ? 79   PHE   A CG   1 
ATOM   374  C  CD1  . PHE   A 1 74  ? 7.70888   -32.50862 10.66968  1.000 31.71037 ? 79   PHE   A CD1  1 
ATOM   375  C  CD2  . PHE   A 1 74  ? 9.45586   -33.72350 11.74684  1.000 30.06604 ? 79   PHE   A CD2  1 
ATOM   376  C  CE1  . PHE   A 1 74  ? 7.20388   -33.68767 10.14680  1.000 31.47755 ? 79   PHE   A CE1  1 
ATOM   377  C  CE2  . PHE   A 1 74  ? 8.95286   -34.90156 11.23096  1.000 36.46572 ? 79   PHE   A CE2  1 
ATOM   378  C  CZ   . PHE   A 1 74  ? 7.82587   -34.88864 10.42994  1.000 33.91262 ? 79   PHE   A CZ   1 
ATOM   379  N  N    . GLU   A 1 75  ? 7.32582   -32.50722 14.28867  1.000 26.13805 ? 80   GLU   A N    1 
ATOM   380  C  CA   . GLU   A 1 75  ? 7.03980   -33.60711 15.19779  1.000 31.19521 ? 80   GLU   A CA   1 
ATOM   381  C  C    . GLU   A 1 75  ? 6.81081   -34.91520 14.46093  1.000 33.75860 ? 80   GLU   A C    1 
ATOM   382  O  O    . GLU   A 1 75  ? 7.46480   -35.91316 14.76805  1.000 33.11567 ? 80   GLU   A O    1 
ATOM   383  C  CB   . GLU   A 1 75  ? 5.82479   -33.26301 16.07573  1.000 30.69658 ? 80   GLU   A CB   1 
ATOM   384  C  CG   . GLU   A 1 75  ? 5.44377   -34.32890 17.08084  1.000 32.32447 ? 80   GLU   A CG   1 
ATOM   385  C  CD   . GLU   A 1 75  ? 6.44075   -34.44478 18.21987  1.000 41.59382 ? 80   GLU   A CD   1 
ATOM   386  O  OE1  . GLU   A 1 75  ? 7.34375   -33.57777 18.33879  1.000 40.23432 ? 80   GLU   A OE1  1 
ATOM   387  O  OE2  . GLU   A 1 75  ? 6.31374   -35.40969 18.99698  1.000 45.20528 ? 80   GLU   A OE2  1 
ATOM   388  N  N    . LYS   A 1 76  ? 5.90982   -34.94130 13.48592  1.000 25.20201 ? 81   LYS   A N    1 
ATOM   389  C  CA   . LYS   A 1 76  ? 5.63383   -36.19637 12.81105  1.000 25.78214 ? 81   LYS   A CA   1 
ATOM   390  C  C    . LYS   A 1 76  ? 4.84385   -35.91651 11.54601  1.000 30.89645 ? 81   LYS   A C    1 
ATOM   391  O  O    . LYS   A 1 76  ? 4.25686   -34.84053 11.37788  1.000 24.91607 ? 81   LYS   A O    1 
ATOM   392  C  CB   . LYS   A 1 76  ? 4.86581   -37.16227 13.71815  1.000 29.28041 ? 81   LYS   A CB   1 
ATOM   393  C  CG   . LYS   A 1 76  ? 3.41181   -36.82425 13.83909  1.000 34.69996 ? 81   LYS   A CG   1 
ATOM   394  C  CD   . LYS   A 1 76  ? 2.87679   -37.12610 15.22211  1.000 42.60329 ? 81   LYS   A CD   1 
ATOM   395  C  CE   . LYS   A 1 76  ? 2.94578   -38.58706 15.54527  1.000 41.07443 ? 81   LYS   A CE   1 
ATOM   396  N  NZ   . LYS   A 1 76  ? 2.29976   -38.84391 16.86129  1.000 41.05350 ? 81   LYS   A NZ   1 
ATOM   397  N  N    . THR   A 1 77  ? 4.84186   -36.91061 10.66312  1.000 25.13182 ? 82   THR   A N    1 
ATOM   398  C  CA   . THR   A 1 77  ? 4.05788   -36.91074 9.44011   1.000 25.49223 ? 82   THR   A CA   1 
ATOM   399  C  C    . THR   A 1 77  ? 2.97788   -37.97872 9.54121   1.000 36.31710 ? 82   THR   A C    1 
ATOM   400  O  O    . THR   A 1 77  ? 3.24386   -39.10268 9.98633   1.000 28.81442 ? 82   THR   A O    1 
ATOM   401  C  CB   . THR   A 1 77  ? 4.94690   -37.17988 8.22515   1.000 28.42265 ? 82   THR   A CB   1 
ATOM   402  O  OG1  . THR   A 1 77  ? 5.92891   -36.14089 8.10805   1.000 26.29890 ? 82   THR   A OG1  1 
ATOM   403  C  CG2  . THR   A 1 77  ? 4.11092   -37.23001 6.95314   1.000 30.13151 ? 82   THR   A CG2  1 
ATOM   404  N  N    . ILE   A 1 78  ? 1.76088   -37.62476 9.15015   1.000 27.76495 ? 83   ILE   A N    1 
ATOM   405  C  CA   . ILE   A 1 78  ? 0.62988   -38.54076 9.14623   1.000 25.29346 ? 83   ILE   A CA   1 
ATOM   406  C  C    . ILE   A 1 78  ? 0.18790   -38.71292 7.70024   1.000 30.28618 ? 83   ILE   A C    1 
ATOM   407  O  O    . ILE   A 1 78  ? 0.01192   -37.72200 6.98013   1.000 29.00600 ? 83   ILE   A O    1 
ATOM   408  C  CB   . ILE   A 1 78  ? -0.50613  -38.01765 10.05116  1.000 28.46852 ? 83   ILE   A CB   1 
ATOM   409  C  CG1  . ILE   A 1 78  ? -0.01216  -37.98450 11.49916  1.000 26.25866 ? 83   ILE   A CG1  1 
ATOM   410  C  CG2  . ILE   A 1 78  ? -1.76013  -38.86166 9.92323   1.000 26.85405 ? 83   ILE   A CG2  1 
ATOM   411  C  CD1  . ILE   A 1 78  ? -0.89917  -37.23439 12.45806  1.000 23.39740 ? 83   ILE   A CD1  1 
ATOM   412  N  N    . SER   A 1 79  ? 0.05191   -39.96497 7.26138   1.000 26.42104 ? 84   SER   A N    1 
ATOM   413  C  CA   . SER   A 1 79  ? -0.17607  -40.25112 5.85141   1.000 28.87268 ? 84   SER   A CA   1 
ATOM   414  C  C    . SER   A 1 79  ? -1.24307  -41.32613 5.68151   1.000 30.04485 ? 84   SER   A C    1 
ATOM   415  O  O    . SER   A 1 79  ? -1.47209  -42.15704 6.56760   1.000 27.93826 ? 84   SER   A O    1 
ATOM   416  C  CB   . SER   A 1 79  ? 1.12294   -40.69920 5.16648   1.000 33.44862 ? 84   SER   A CB   1 
ATOM   417  O  OG   . SER   A 1 79  ? 1.50692   -41.96715 5.65162   1.000 36.30890 ? 84   SER   A OG   1 
ATOM   418  N  N    . GLY   A 1 80  ? -1.88606  -41.30226 4.51450   1.000 26.15907 ? 85   GLY   A N    1 
ATOM   419  C  CA   . GLY   A 1 80  ? -2.90505  -42.26530 4.16459   1.000 27.97569 ? 85   GLY   A CA   1 
ATOM   420  C  C    . GLY   A 1 80  ? -3.83503  -41.79341 3.06252   1.000 31.09603 ? 85   GLY   A C    1 
ATOM   421  O  O    . GLY   A 1 80  ? -4.31303  -42.61350 2.27660   1.000 27.65089 ? 85   GLY   A O    1 
ATOM   422  N  N    . HIS   A 1 81  ? -4.12203  -40.49142 2.99137   1.000 22.26269 ? 86   HIS   A N    1 
ATOM   423  C  CA   . HIS   A 1 81  ? -4.95601  -39.99754 1.90030   1.000 24.16328 ? 86   HIS   A CA   1 
ATOM   424  C  C    . HIS   A 1 81  ? -4.29399  -40.30169 0.56135   1.000 28.17606 ? 86   HIS   A C    1 
ATOM   425  O  O    . HIS   A 1 81  ? -3.06799  -40.32671 0.44237   1.000 25.63752 ? 86   HIS   A O    1 
ATOM   426  C  CB   . HIS   A 1 81  ? -5.21201  -38.49052 2.04813   1.000 20.21858 ? 86   HIS   A CB   1 
ATOM   427  C  CG   . HIS   A 1 81  ? -6.36502  -38.17342 2.95508   1.000 22.04262 ? 86   HIS   A CG   1 
ATOM   428  N  ND1  . HIS   A 1 81  ? -7.65902  -38.56344 2.67210   1.000 23.46731 ? 86   HIS   A ND1  1 
ATOM   429  C  CD2  . HIS   A 1 81  ? -6.41504  -37.54328 4.15701   1.000 22.55291 ? 86   HIS   A CD2  1 
ATOM   430  C  CE1  . HIS   A 1 81  ? -8.45803  -38.17033 3.65305   1.000 24.43734 ? 86   HIS   A CE1  1 
ATOM   431  N  NE2  . HIS   A 1 81  ? -7.72804  -37.54323 4.56199   1.000 23.70403 ? 86   HIS   A NE2  1 
ATOM   432  N  N    . LYS   A 1 82  ? -5.12497  -40.52880 -0.45764  1.000 27.64362 ? 87   LYS   A N    1 
ATOM   433  C  CA   . LYS   A 1 82  ? -4.62195  -40.90495 -1.77259  1.000 26.56926 ? 87   LYS   A CA   1 
ATOM   434  C  C    . LYS   A 1 82  ? -4.37894  -39.71105 -2.68572  1.000 31.60844 ? 87   LYS   A C    1 
ATOM   435  O  O    . LYS   A 1 82  ? -3.68692  -39.85416 -3.69669  1.000 30.70350 ? 87   LYS   A O    1 
ATOM   436  C  CB   . LYS   A 1 82  ? -5.59795  -41.86702 -2.45850  1.000 32.13550 ? 87   LYS   A CB   1 
ATOM   437  C  CG   . LYS   A 1 82  ? -5.72296  -43.24194 -1.79735  1.000 42.46424 ? 87   LYS   A CG   1 
ATOM   438  C  CD   . LYS   A 1 82  ? -6.73295  -44.14602 -2.52027  1.000 55.01864 ? 87   LYS   A CD   1 
ATOM   439  C  CE   . LYS   A 1 82  ? -6.84797  -45.54095 -1.87611  1.000 67.73086 ? 87   LYS   A CE   1 
ATOM   440  N  NZ   . LYS   A 1 82  ? -7.85096  -46.41202 -2.56703  1.000 70.49206 ? 87   LYS   A NZ   1 
ATOM   441  N  N    . LEU   A 1 83  ? -4.94394  -38.55001 -2.36186  1.000 26.46377 ? 88   LEU   A N    1 
ATOM   442  C  CA   . LEU   A 1 83  ? -4.77992  -37.33210 -3.14399  1.000 25.05518 ? 88   LEU   A CA   1 
ATOM   443  C  C    . LEU   A 1 83  ? -4.63693  -36.17299 -2.16411  1.000 27.96203 ? 88   LEU   A C    1 
ATOM   444  O  O    . LEU   A 1 83  ? -4.67295  -36.36185 -0.94509  1.000 25.28330 ? 88   LEU   A O    1 
ATOM   445  C  CB   . LEU   A 1 83  ? -5.95290  -37.12220 -4.11703  1.000 25.08716 ? 88   LEU   A CB   1 
ATOM   446  C  CG   . LEU   A 1 83  ? -6.18889  -38.10833 -5.28093  1.000 27.98572 ? 88   LEU   A CG   1 
ATOM   447  C  CD1  . LEU   A 1 83  ? -7.54788  -37.88440 -5.96097  1.000 24.51997 ? 88   LEU   A CD1  1 
ATOM   448  C  CD2  . LEU   A 1 83  ? -5.06187  -38.01745 -6.32592  1.000 26.23571 ? 88   LEU   A CD2  1 
ATOM   449  N  N    . GLY   A 1 84  ? -4.45692  -34.96305 -2.70525  1.000 22.46689 ? 89   GLY   A N    1 
ATOM   450  C  CA   . GLY   A 1 84  ? -4.23893  -33.77896 -1.89637  1.000 23.33236 ? 89   GLY   A CA   1 
ATOM   451  C  C    . GLY   A 1 84  ? -5.27494  -33.58684 -0.80341  1.000 27.20827 ? 89   GLY   A C    1 
ATOM   452  O  O    . GLY   A 1 84  ? -6.42494  -34.02985 -0.93038  1.000 23.71321 ? 89   GLY   A O    1 
ATOM   453  N  N    . ILE   A 1 85  ? -4.86196  -32.94972 0.28653   1.000 21.45812 ? 90   ILE   A N    1 
ATOM   454  C  CA   . ILE   A 1 85  ? -5.72197  -32.67459 1.42748   1.000 26.52255 ? 90   ILE   A CA   1 
ATOM   455  C  C    . ILE   A 1 85  ? -6.04297  -31.18959 1.43931   1.000 26.54157 ? 90   ILE   A C    1 
ATOM   456  O  O    . ILE   A 1 85  ? -5.13896  -30.34960 1.33323   1.000 22.19805 ? 90   ILE   A O    1 
ATOM   457  C  CB   . ILE   A 1 85  ? -5.05500  -33.08944 2.74754   1.000 23.52887 ? 90   ILE   A CB   1 
ATOM   458  C  CG1  . ILE   A 1 85  ? -4.74600  -34.58845 2.72171   1.000 23.91603 ? 90   ILE   A CG1  1 
ATOM   459  C  CG2  . ILE   A 1 85  ? -5.97501  -32.72931 3.91448   1.000 20.15081 ? 90   ILE   A CG2  1 
ATOM   460  C  CD1  . ILE   A 1 85  ? -3.82802  -35.02333 3.86277   1.000 21.78999 ? 90   ILE   A CD1  1 
ATOM   461  N  N    . SER   A 1 86  ? -7.32897  -30.87457 1.57926   1.000 21.03037 ? 91   SER   A N    1 
ATOM   462  C  CA   . SER   A 1 86  ? -7.85297  -29.51756 1.57610   1.000 18.37500 ? 91   SER   A CA   1 
ATOM   463  C  C    . SER   A 1 86  ? -7.91299  -28.90041 2.96903   1.000 17.79633 ? 91   SER   A C    1 
ATOM   464  O  O    . SER   A 1 86  ? -7.74398  -27.68539 3.11390   1.000 19.71124 ? 91   SER   A O    1 
ATOM   465  C  CB   . SER   A 1 86  ? -9.26096  -29.53463 0.96008   1.000 20.72993 ? 91   SER   A CB   1 
ATOM   466  O  OG   . SER   A 1 86  ? -9.77895  -28.23464 0.80193   1.000 24.85963 ? 91   SER   A OG   1 
ATOM   467  N  N    . ASP   A 1 87  ? -8.15900  -29.69729 4.00511   1.000 20.49402 ? 92   ASP   A N    1 
ATOM   468  C  CA   . ASP   A 1 87  ? -8.44602  -29.12715 5.31305   1.000 20.82680 ? 92   ASP   A CA   1 
ATOM   469  C  C    . ASP   A 1 87  ? -8.15204  -30.16903 6.37617   1.000 18.75878 ? 92   ASP   A C    1 
ATOM   470  O  O    . ASP   A 1 87  ? -8.17304  -31.37406 6.11730   1.000 20.78905 ? 92   ASP   A O    1 
ATOM   471  C  CB   . ASP   A 1 87  ? -9.91002  -28.67313 5.40197   1.000 18.58486 ? 92   ASP   A CB   1 
ATOM   472  C  CG   . ASP   A 1 87  ? -10.18004 -27.71501 6.55286   1.000 22.20695 ? 92   ASP   A CG   1 
ATOM   473  O  OD1  . ASP   A 1 87  ? -9.22805  -27.14394 7.15582   1.000 23.46909 ? 92   ASP   A OD1  1 
ATOM   474  O  OD2  . ASP   A 1 87  ? -11.38504 -27.52897 6.84782   1.000 23.81067 ? 92   ASP   A OD2  1 
ATOM   475  N  N    A VAL   A 1 88  ? -7.87506  -29.68390 7.58312   0.110 21.95969 ? 93   VAL   A N    1 
ATOM   476  N  N    B VAL   A 1 88  ? -7.88906  -29.68490 7.58112   0.890 22.02213 ? 93   VAL   A N    1 
ATOM   477  C  CA   A VAL   A 1 88  ? -7.66308  -30.54477 8.74122   0.110 21.50049 ? 93   VAL   A CA   1 
ATOM   478  C  CA   B VAL   A 1 88  ? -7.66608  -30.55677 8.72722   0.890 21.46004 ? 93   VAL   A CA   1 
ATOM   479  C  C    A VAL   A 1 88  ? -8.20810  -29.82464 9.96213   0.110 20.69023 ? 93   VAL   A C    1 
ATOM   480  C  C    B VAL   A 1 88  ? -8.23610  -29.83164 9.93013   0.890 20.56616 ? 93   VAL   A C    1 
ATOM   481  O  O    A VAL   A 1 88  ? -8.18810  -28.59263 10.03499  0.110 22.09326 ? 93   VAL   A O    1 
ATOM   482  O  O    B VAL   A 1 88  ? -8.28110  -28.59964 9.94999   0.890 22.17053 ? 93   VAL   A O    1 
ATOM   483  C  CB   A VAL   A 1 88  ? -6.17109  -30.90976 8.93028   0.110 22.72994 ? 93   VAL   A CB   1 
ATOM   484  C  CB   B VAL   A 1 88  ? -6.15809  -30.89776 8.89528   0.890 22.76757 ? 93   VAL   A CB   1 
ATOM   485  C  CG1  A VAL   A 1 88  ? -5.70707  -31.83588 7.82039   0.110 21.97187 ? 93   VAL   A CG1  1 
ATOM   486  C  CG1  B VAL   A 1 88  ? -5.36609  -29.68371 9.35416   0.890 22.42323 ? 93   VAL   A CG1  1 
ATOM   487  C  CG2  A VAL   A 1 88  ? -5.32008  -29.65176 8.97215   0.110 22.14868 ? 93   VAL   A CG2  1 
ATOM   488  C  CG2  B VAL   A 1 88  ? -5.97911  -32.06266 9.84641   0.890 24.10404 ? 93   VAL   A CG2  1 
ATOM   489  N  N    . ALA   A 1 89  ? -8.70212  -30.59853 10.92721  1.000 21.01911 ? 94   ALA   A N    1 
ATOM   490  C  CA   . ALA   A 1 89  ? -9.27314  -30.01539 12.13413  1.000 21.76856 ? 94   ALA   A CA   1 
ATOM   491  C  C    . ALA   A 1 89  ? -9.05516  -30.93426 13.32624  1.000 22.82681 ? 94   ALA   A C    1 
ATOM   492  O  O    . ALA   A 1 89  ? -9.03116  -32.15728 13.18237  1.000 25.97356 ? 94   ALA   A O    1 
ATOM   493  C  CB   . ALA   A 1 89  ? -10.77613 -29.73740 11.97108  1.000 23.46000 ? 94   ALA   A CB   1 
ATOM   494  N  N    . TRP   A 1 90  ? -8.93517  -30.32313 14.50717  1.000 21.95166 ? 95   TRP   A N    1 
ATOM   495  C  CA   . TRP   A 1 90  ? -8.69620  -31.00199 15.77725  1.000 23.02078 ? 95   TRP   A CA   1 
ATOM   496  C  C    . TRP   A 1 90  ? -9.99621  -31.32190 16.52626  1.000 27.95357 ? 95   TRP   A C    1 
ATOM   497  O  O    . TRP   A 1 90  ? -10.95321 -30.54290 16.50916  1.000 26.45105 ? 95   TRP   A O    1 
ATOM   498  C  CB   . TRP   A 1 90  ? -7.83821  -30.11989 16.69117  1.000 24.83427 ? 95   TRP   A CB   1 
ATOM   499  C  CG   . TRP   A 1 90  ? -6.43720  -29.85895 16.25716  1.000 23.77361 ? 95   TRP   A CG   1 
ATOM   500  C  CD1  . TRP   A 1 90  ? -5.98518  -28.81803 15.49205  1.000 22.82067 ? 95   TRP   A CD1  1 
ATOM   501  C  CD2  . TRP   A 1 90  ? -5.28421  -30.63191 16.60726  1.000 27.43721 ? 95   TRP   A CD2  1 
ATOM   502  N  NE1  . TRP   A 1 90  ? -4.61118  -28.90606 15.33508  1.000 22.46225 ? 95   TRP   A NE1  1 
ATOM   503  C  CE2  . TRP   A 1 90  ? -4.16320  -30.01198 16.00821  1.000 24.69887 ? 95   TRP   A CE2  1 
ATOM   504  C  CE3  . TRP   A 1 90  ? -5.09023  -31.79483 17.36740  1.000 26.69657 ? 95   TRP   A CE3  1 
ATOM   505  C  CZ2  . TRP   A 1 90  ? -2.87320  -30.51697 16.14529  1.000 25.14385 ? 95   TRP   A CZ2  1 
ATOM   506  C  CZ3  . TRP   A 1 90  ? -3.79523  -32.29782 17.49847  1.000 26.69906 ? 95   TRP   A CZ3  1 
ATOM   507  C  CH2  . TRP   A 1 90  ? -2.70922  -31.65589 16.89142  1.000 28.14458 ? 95   TRP   A CH2  1 
ATOM   508  N  N    . SER   A 1 91  ? -9.99823  -32.44783 17.24239  1.000 26.48182 ? 96   SER   A N    1 
ATOM   509  C  CA   . SER   A 1 91  ? -11.04024 -32.68071 18.23640  1.000 29.04762 ? 96   SER   A CA   1 
ATOM   510  C  C    . SER   A 1 91  ? -10.80726 -31.78958 19.45830  1.000 29.19942 ? 96   SER   A C    1 
ATOM   511  O  O    . SER   A 1 91  ? -9.70126  -31.29855 19.70427  1.000 27.27685 ? 96   SER   A O    1 
ATOM   512  C  CB   . SER   A 1 91  ? -11.08925 -34.15767 18.65156  1.000 26.31341 ? 96   SER   A CB   1 
ATOM   513  O  OG   . SER   A 1 91  ? -9.84927  -34.60061 19.20263  1.000 26.24883 ? 96   SER   A OG   1 
ATOM   514  N  N    . SER   A 1 92  ? -11.87427 -31.57949 20.23526  1.000 28.23620 ? 97   SER   A N    1 
ATOM   515  C  CA   A SER   A 1 92  ? -11.79828 -30.62237 21.33216  0.627 30.93779 ? 97   SER   A CA   1 
ATOM   516  C  CA   B SER   A 1 92  ? -11.80128 -30.62337 21.33416  0.373 30.92474 ? 97   SER   A CA   1 
ATOM   517  C  C    . SER   A 1 92  ? -10.75230 -31.01826 22.36522  1.000 26.95573 ? 97   SER   A C    1 
ATOM   518  O  O    . SER   A 1 92  ? -10.23831 -30.15418 23.08413  1.000 30.25061 ? 97   SER   A O    1 
ATOM   519  C  CB   A SER   A 1 92  ? -13.16429 -30.47929 21.99912  0.627 30.88608 ? 97   SER   A CB   1 
ATOM   520  C  CB   B SER   A 1 92  ? -13.16729 -30.48329 22.00512  0.373 30.90995 ? 97   SER   A CB   1 
ATOM   521  O  OG   A SER   A 1 92  ? -14.13328 -30.07839 21.05406  0.627 36.70804 ? 97   SER   A OG   1 
ATOM   522  O  OG   B SER   A 1 92  ? -13.56731 -31.70322 22.60425  0.373 32.86151 ? 97   SER   A OG   1 
ATOM   523  N  N    . ASP   A 1 93  ? -10.42231 -32.29725 22.46537  1.000 26.52350 ? 98   ASP   A N    1 
ATOM   524  C  CA   . ASP   A 1 93  ? -9.43833  -32.73214 23.44643  1.000 32.40898 ? 98   ASP   A CA   1 
ATOM   525  C  C    . ASP   A 1 93  ? -8.03632  -32.87321 22.85847  1.000 34.00754 ? 98   ASP   A C    1 
ATOM   526  O  O    . ASP   A 1 93  ? -7.15833  -33.43214 23.52154  1.000 32.47003 ? 98   ASP   A O    1 
ATOM   527  C  CB   . ASP   A 1 93  ? -9.87534  -34.04907 24.09457  1.000 30.81993 ? 98   ASP   A CB   1 
ATOM   528  C  CG   . ASP   A 1 93  ? -9.81333  -35.23018 23.13670  1.000 35.23826 ? 98   ASP   A CG   1 
ATOM   529  O  OD1  . ASP   A 1 93  ? -9.39331  -35.06531 21.97069  1.000 34.09329 ? 98   ASP   A OD1  1 
ATOM   530  O  OD2  . ASP   A 1 93  ? -10.19034 -36.34513 23.55182  1.000 42.57927 ? 98   ASP   A OD2  1 
ATOM   531  N  N    . SER   A 1 94  ? -7.80930  -32.39435 21.63342  1.000 27.61639 ? 99   SER   A N    1 
ATOM   532  C  CA   . SER   A 1 94  ? -6.49629  -32.39443 20.98444  1.000 27.05009 ? 99   SER   A CA   1 
ATOM   533  C  C    . SER   A 1 94  ? -5.96729  -33.78746 20.69160  1.000 29.05850 ? 99   SER   A C    1 
ATOM   534  O  O    . SER   A 1 94  ? -4.78128  -33.93750 20.37264  1.000 29.80965 ? 99   SER   A O    1 
ATOM   535  C  CB   . SER   A 1 94  ? -5.44530  -31.64334 21.80937  1.000 27.25961 ? 99   SER   A CB   1 
ATOM   536  O  OG   . SER   A 1 94  ? -5.85129  -30.31831 22.07622  1.000 25.83287 ? 99   SER   A OG   1 
ATOM   537  N  N    . ASN   A 1 95  ? -6.79629  -34.81945 20.77470  1.000 31.16573 ? 100  ASN   A N    1 
ATOM   538  C  CA   . ASN   A 1 95  ? -6.26829  -36.15447 20.54486  1.000 33.20854 ? 100  ASN   A CA   1 
ATOM   539  C  C    . ASN   A 1 95  ? -6.53727  -36.68363 19.14791  1.000 34.90124 ? 100  ASN   A C    1 
ATOM   540  O  O    . ASN   A 1 95  ? -5.80927  -37.57668 18.69902  1.000 32.24558 ? 100  ASN   A O    1 
ATOM   541  C  CB   . ASN   A 1 95  ? -6.82631  -37.12536 21.58096  1.000 35.07721 ? 100  ASN   A CB   1 
ATOM   542  C  CG   . ASN   A 1 95  ? -6.14233  -36.97521 22.92095  1.000 37.70705 ? 100  ASN   A CG   1 
ATOM   543  O  OD1  . ASN   A 1 95  ? -4.90733  -36.93521 23.00097  1.000 36.99666 ? 100  ASN   A OD1  1 
ATOM   544  N  ND2  . ASN   A 1 95  ? -6.93635  -36.86309 23.98293  1.000 41.75213 ? 100  ASN   A ND2  1 
ATOM   545  N  N    . LEU   A 1 96  ? -7.54326  -36.15170 18.44984  1.000 26.56156 ? 101  LEU   A N    1 
ATOM   546  C  CA   . LEU   A 1 96  ? -7.91924  -36.63584 17.13488  1.000 25.48358 ? 101  LEU   A CA   1 
ATOM   547  C  C    . LEU   A 1 96  ? -7.78522  -35.52896 16.10376  1.000 28.45114 ? 101  LEU   A C    1 
ATOM   548  O  O    . LEU   A 1 96  ? -7.90922  -34.34292 16.42363  1.000 26.50431 ? 101  LEU   A O    1 
ATOM   549  C  CB   . LEU   A 1 96  ? -9.36524  -37.14584 17.11892  1.000 28.35190 ? 101  LEU   A CB   1 
ATOM   550  C  CG   . LEU   A 1 96  ? -9.79026  -38.20773 18.13503  1.000 33.39341 ? 101  LEU   A CG   1 
ATOM   551  C  CD1  . LEU   A 1 96  ? -11.25326 -38.50974 17.93304  1.000 28.76107 ? 101  LEU   A CD1  1 
ATOM   552  C  CD2  . LEU   A 1 96  ? -8.96326  -39.47075 17.99718  1.000 27.51681 ? 101  LEU   A CD2  1 
ATOM   553  N  N    . LEU   A 1 97  ? -7.54820  -35.93110 14.85481  1.000 26.35115 ? 102  LEU   A N    1 
ATOM   554  C  CA   . LEU   A 1 97  ? -7.67618  -35.04022 13.71471  1.000 21.80178 ? 102  LEU   A CA   1 
ATOM   555  C  C    . LEU   A 1 97  ? -8.70017  -35.61533 12.74876  1.000 26.98565 ? 102  LEU   A C    1 
ATOM   556  O  O    . LEU   A 1 97  ? -8.91917  -36.82833 12.69789  1.000 27.36848 ? 102  LEU   A O    1 
ATOM   557  C  CB   . LEU   A 1 97  ? -6.35217  -34.84531 12.97171  1.000 21.74599 ? 102  LEU   A CB   1 
ATOM   558  C  CG   . LEU   A 1 97  ? -5.22718  -34.09224 13.67065  1.000 31.08636 ? 102  LEU   A CG   1 
ATOM   559  C  CD1  . LEU   A 1 97  ? -3.97316  -34.23034 12.80768  1.000 26.51642 ? 102  LEU   A CD1  1 
ATOM   560  C  CD2  . LEU   A 1 97  ? -5.60217  -32.63021 13.86448  1.000 26.89542 ? 102  LEU   A CD2  1 
ATOM   561  N  N    . VAL   A 1 98  ? -9.32115  -34.73241 11.98165  1.000 22.70988 ? 103  VAL   A N    1 
ATOM   562  C  CA   . VAL   A 1 98  ? -10.07113 -35.11554 10.79968  1.000 22.93579 ? 103  VAL   A CA   1 
ATOM   563  C  C    . VAL   A 1 98  ? -9.50211  -34.32667 9.62860   1.000 21.17888 ? 103  VAL   A C    1 
ATOM   564  O  O    . VAL   A 1 98  ? -9.11711  -33.15965 9.77948   1.000 25.21727 ? 103  VAL   A O    1 
ATOM   565  C  CB   . VAL   A 1 98  ? -11.59613 -34.88451 10.96163  1.000 25.78635 ? 103  VAL   A CB   1 
ATOM   566  C  CG1  . VAL   A 1 98  ? -11.92213 -33.39849 11.17446  1.000 23.99485 ? 103  VAL   A CG1  1 
ATOM   567  C  CG2  . VAL   A 1 98  ? -12.36912 -35.44864 9.75968   1.000 22.19503 ? 103  VAL   A CG2  1 
ATOM   568  N  N    . SER   A 1 99  ? -9.42710  -34.97080 8.47468   1.000 23.28571 ? 104  SER   A N    1 
ATOM   569  C  CA   . SER   A 1 99  ? -8.94207  -34.34293 7.25962   1.000 23.96369 ? 104  SER   A CA   1 
ATOM   570  C  C    . SER   A 1 99  ? -9.92806  -34.58505 6.12063   1.000 25.08301 ? 104  SER   A C    1 
ATOM   571  O  O    . SER   A 1 99  ? -10.63706 -35.59805 6.09173   1.000 24.47197 ? 104  SER   A O    1 
ATOM   572  C  CB   . SER   A 1 99  ? -7.56307  -34.88898 6.88170   1.000 23.86979 ? 104  SER   A CB   1 
ATOM   573  O  OG   . SER   A 1 99  ? -7.61107  -36.30299 6.74785   1.000 23.95399 ? 104  SER   A OG   1 
ATOM   574  N  N    . ALA   A 1 100 ? -9.94304  -33.65016 5.17452   1.000 24.42005 ? 105  ALA   A N    1 
ATOM   575  C  CA   . ALA   A 1 100 ? -10.85202 -33.66428 4.03151   1.000 20.81774 ? 105  ALA   A CA   1 
ATOM   576  C  C    . ALA   A 1 100 ? -10.01200 -33.64142 2.75752   1.000 25.46085 ? 105  ALA   A C    1 
ATOM   577  O  O    . ALA   A 1 100 ? -9.14099  -32.77544 2.61144   1.000 18.79422 ? 105  ALA   A O    1 
ATOM   578  C  CB   . ALA   A 1 100 ? -11.78502 -32.45027 4.07936   1.000 19.36337 ? 105  ALA   A CB   1 
ATOM   579  N  N    . SER   A 1 101 ? -10.27599 -34.56653 1.82762   1.000 22.33182 ? 106  SER   A N    1 
ATOM   580  C  CA   . SER   A 1 101 ? -9.33897  -34.81265 0.73666   1.000 23.44632 ? 106  SER   A CA   1 
ATOM   581  C  C    . SER   A 1 101 ? -10.01195 -34.82980 -0.63235  1.000 22.20786 ? 106  SER   A C    1 
ATOM   582  O  O    . SER   A 1 101 ? -11.19595 -35.15381 -0.76833  1.000 23.86840 ? 106  SER   A O    1 
ATOM   583  C  CB   . SER   A 1 101 ? -8.58698  -36.14763 0.95082   1.000 23.06939 ? 106  SER   A CB   1 
ATOM   584  O  OG   . SER   A 1 101 ? -7.79496  -36.47276 -0.18813  1.000 23.28796 ? 106  SER   A OG   1 
ATOM   585  N  N    . ASP   A 1 102 ? -9.21993  -34.47092 -1.65738  1.000 23.86592 ? 107  ASP   A N    1 
ATOM   586  C  CA   . ASP   A 1 102 ? -9.59791  -34.69107 -3.05036  1.000 23.40854 ? 107  ASP   A CA   1 
ATOM   587  C  C    . ASP   A 1 102 ? -9.93491  -36.14510 -3.34820  1.000 26.70404 ? 107  ASP   A C    1 
ATOM   588  O  O    . ASP   A 1 102 ? -10.57990 -36.41521 -4.36018  1.000 23.33742 ? 107  ASP   A O    1 
ATOM   589  C  CB   . ASP   A 1 102 ? -8.47689  -34.28518 -4.00438  1.000 25.30458 ? 107  ASP   A CB   1 
ATOM   590  C  CG   . ASP   A 1 102 ? -8.36189  -32.78020 -4.17655  1.000 33.20446 ? 107  ASP   A CG   1 
ATOM   591  O  OD1  . ASP   A 1 102 ? -9.25689  -32.04314 -3.71664  1.000 27.02582 ? 107  ASP   A OD1  1 
ATOM   592  O  OD2  . ASP   A 1 102 ? -7.35887  -32.34027 -4.77358  1.000 31.78075 ? 107  ASP   A OD2  1 
ATOM   593  N  N    . ASP   A 1 103 ? -9.48093  -37.08601 -2.53209  1.000 24.04284 ? 108  ASP   A N    1 
ATOM   594  C  CA   . ASP   A 1 103 ? -9.81693  -38.47204 -2.80294  1.000 26.57185 ? 108  ASP   A CA   1 
ATOM   595  C  C    . ASP   A 1 103 ? -11.25494 -38.80699 -2.40993  1.000 26.48460 ? 108  ASP   A C    1 
ATOM   596  O  O    . ASP   A 1 103 ? -11.62794 -39.98199 -2.39980  1.000 26.06140 ? 108  ASP   A O    1 
ATOM   597  C  CB   . ASP   A 1 103 ? -8.81794  -39.41397 -2.11582  1.000 24.61095 ? 108  ASP   A CB   1 
ATOM   598  C  CG   . ASP   A 1 103 ? -8.90597  -39.39580 -0.59583  1.000 26.54979 ? 108  ASP   A CG   1 
ATOM   599  O  OD1  . ASP   A 1 103 ? -9.91598  -38.91573 -0.01290  1.000 24.29604 ? 108  ASP   A OD1  1 
ATOM   600  O  OD2  . ASP   A 1 103 ? -7.94098  -39.89173 0.02524   1.000 25.46223 ? 108  ASP   A OD2  1 
ATOM   601  N  N    . LYS   A 1 104 ? -12.07894 -37.80895 -2.10405  1.000 24.58348 ? 109  LYS   A N    1 
ATOM   602  C  CA   . LYS   A 1 104 ? -13.50794 -37.97692 -1.84806  1.000 28.90737 ? 109  LYS   A CA   1 
ATOM   603  C  C    . LYS   A 1 104 ? -13.78997 -38.50176 -0.44400  1.000 25.18904 ? 109  LYS   A C    1 
ATOM   604  O  O    . LYS   A 1 104 ? -14.97597 -38.73772 -0.10700  1.000 25.52541 ? 109  LYS   A O    1 
ATOM   605  C  CB   . LYS   A 1 104 ? -14.18993 -38.92303 -2.85396  1.000 25.96450 ? 109  LYS   A CB   1 
ATOM   606  C  CG   . LYS   A 1 104 ? -14.08091 -38.53319 -4.32200  1.000 29.89555 ? 109  LYS   A CG   1 
ATOM   607  C  CD   . LYS   A 1 104 ? -14.83590 -39.57128 -5.17190  1.000 28.71420 ? 109  LYS   A CD   1 
ATOM   608  C  CE   . LYS   A 1 104 ? -15.10187 -39.09244 -6.58096  1.000 45.55505 ? 109  LYS   A CE   1 
ATOM   609  N  NZ   . LYS   A 1 104 ? -13.87186 -38.95353 -7.41095  1.000 53.83195 ? 109  LYS   A NZ   1 
ATOM   610  N  N    . THR   A 1 105 ? -12.77998 -38.69468 0.39403   1.000 22.85585 ? 110  THR   A N    1 
ATOM   611  C  CA   . THR   A 1 105 ? -13.02000 -39.17553 1.74408   1.000 24.77823 ? 110  THR   A CA   1 
ATOM   612  C  C    . THR   A 1 105 ? -12.57102 -38.13842 2.75598   1.000 27.19275 ? 110  THR   A C    1 
ATOM   613  O  O    . THR   A 1 105 ? -11.80901 -37.22045 2.44389   1.000 26.64813 ? 110  THR   A O    1 
ATOM   614  C  CB   . THR   A 1 105 ? -12.27101 -40.48850 2.03724   1.000 24.29348 ? 110  THR   A CB   1 
ATOM   615  O  OG1  . THR   A 1 105 ? -10.87902 -40.19648 2.21623   1.000 27.92048 ? 110  THR   A OG1  1 
ATOM   616  C  CG2  . THR   A 1 105 ? -12.43000 -41.47462 0.89435   1.000 24.33874 ? 110  THR   A CG2  1 
ATOM   617  N  N    . LEU   A 1 106 ? -13.05404 -38.30128 3.98299   1.000 22.65575 ? 111  LEU   A N    1 
ATOM   618  C  CA   . LEU   A 1 106 ? -12.40605 -37.74415 5.15394   1.000 21.34624 ? 111  LEU   A CA   1 
ATOM   619  C  C    . LEU   A 1 106 ? -11.78807 -38.89207 5.94107   1.000 25.74228 ? 111  LEU   A C    1 
ATOM   620  O  O    . LEU   A 1 106 ? -12.20507 -40.05008 5.82719   1.000 24.34242 ? 111  LEU   A O    1 
ATOM   621  C  CB   . LEU   A 1 106 ? -13.39406 -36.96205 6.03483   1.000 23.24171 ? 111  LEU   A CB   1 
ATOM   622  C  CG   . LEU   A 1 106 ? -14.24505 -35.88812 5.35370   1.000 22.10385 ? 111  LEU   A CG   1 
ATOM   623  C  CD1  . LEU   A 1 106 ? -15.66105 -36.39615 5.09773   1.000 24.61375 ? 111  LEU   A CD1  1 
ATOM   624  C  CD2  . LEU   A 1 106 ? -14.28106 -34.59503 6.19656   1.000 21.16956 ? 111  LEU   A CD2  1 
ATOM   625  N  N    . LYS   A 1 107 ? -10.77308 -38.56798 6.73005   1.000 26.36657 ? 112  LYS   A N    1 
ATOM   626  C  CA   . LYS   A 1 107 ? -10.12210 -39.55389 7.57917   1.000 27.73101 ? 112  LYS   A CA   1 
ATOM   627  C  C    . LYS   A 1 107 ? -10.02412 -39.00774 8.99411   1.000 29.67364 ? 112  LYS   A C    1 
ATOM   628  O  O    . LYS   A 1 107 ? -9.73812  -37.81871 9.19699   1.000 27.25761 ? 112  LYS   A O    1 
ATOM   629  C  CB   . LYS   A 1 107 ? -8.73909  -39.93696 7.04524   1.000 27.49267 ? 112  LYS   A CB   1 
ATOM   630  C  CG   . LYS   A 1 107 ? -8.81408  -40.88409 5.82734   1.000 24.93963 ? 112  LYS   A CG   1 
ATOM   631  C  CD   . LYS   A 1 107 ? -7.44107  -41.22616 5.26140   1.000 26.75763 ? 112  LYS   A CD   1 
ATOM   632  C  CE   . LYS   A 1 107 ? -7.55105  -42.12330 4.01250   1.000 28.69103 ? 112  LYS   A CE   1 
ATOM   633  N  NZ   . LYS   A 1 107 ? -7.91406  -43.54025 4.36865   1.000 29.53159 ? 112  LYS   A NZ   1 
ATOM   634  N  N    . ILE   A 1 108 ? -10.33314 -39.87163 9.96020   1.000 22.40970 ? 113  ILE   A N    1 
ATOM   635  C  CA   . ILE   A 1 108 ? -10.17916 -39.57447 11.38017  1.000 24.63171 ? 113  ILE   A CA   1 
ATOM   636  C  C    . ILE   A 1 108 ? -8.87817  -40.21643 11.82826  1.000 28.95756 ? 113  ILE   A C    1 
ATOM   637  O  O    . ILE   A 1 108 ? -8.62517  -41.39446 11.52740  1.000 27.92126 ? 113  ILE   A O    1 
ATOM   638  C  CB   . ILE   A 1 108 ? -11.36217 -40.10338 12.21021  1.000 26.29740 ? 113  ILE   A CB   1 
ATOM   639  C  CG1  . ILE   A 1 108 ? -12.70116 -39.60443 11.64014  1.000 27.56898 ? 113  ILE   A CG1  1 
ATOM   640  C  CG2  . ILE   A 1 108 ? -11.20120 -39.69821 13.69217  1.000 25.88222 ? 113  ILE   A CG2  1 
ATOM   641  C  CD1  . ILE   A 1 108 ? -13.92818 -40.07934 12.45117  1.000 26.45143 ? 113  ILE   A CD1  1 
ATOM   642  N  N    . TRP   A 1 109 ? -8.04418  -39.44335 12.52819  1.000 28.07812 ? 114  TRP   A N    1 
ATOM   643  C  CA   . TRP   A 1 109 ? -6.69618  -39.86032 12.88826  1.000 25.64934 ? 114  TRP   A CA   1 
ATOM   644  C  C    . TRP   A 1 109 ? -6.52221  -39.79815 14.39326  1.000 27.09892 ? 114  TRP   A C    1 
ATOM   645  O  O    . TRP   A 1 109 ? -6.96321  -38.84708 15.04014  1.000 27.03205 ? 114  TRP   A O    1 
ATOM   646  C  CB   . TRP   A 1 109 ? -5.63217  -38.96539 12.25418  1.000 24.35506 ? 114  TRP   A CB   1 
ATOM   647  C  CG   . TRP   A 1 109 ? -5.76115  -38.75055 10.78215  1.000 25.52139 ? 114  TRP   A CG   1 
ATOM   648  C  CD1  . TRP   A 1 109 ? -6.45613  -37.74262 10.14803  1.000 22.68069 ? 114  TRP   A CD1  1 
ATOM   649  C  CD2  . TRP   A 1 109 ? -5.15013  -39.52867 9.74725   1.000 24.48713 ? 114  TRP   A CD2  1 
ATOM   650  N  NE1  . TRP   A 1 109 ? -6.31611  -37.86777 8.78405   1.000 22.91196 ? 114  TRP   A NE1  1 
ATOM   651  C  CE2  . TRP   A 1 109 ? -5.51911  -38.94881 8.51118   1.000 24.42109 ? 114  TRP   A CE2  1 
ATOM   652  C  CE3  . TRP   A 1 109 ? -4.33614  -40.66667 9.74339   1.000 28.93411 ? 114  TRP   A CE3  1 
ATOM   653  C  CZ2  . TRP   A 1 109 ? -5.10309  -39.47194 7.28624   1.000 25.72917 ? 114  TRP   A CZ2  1 
ATOM   654  C  CZ3  . TRP   A 1 109 ? -3.92112  -41.17881 8.52545   1.000 28.04278 ? 114  TRP   A CZ3  1 
ATOM   655  C  CH2  . TRP   A 1 109 ? -4.30410  -40.58294 7.31438   1.000 25.52676 ? 114  TRP   A CH2  1 
ATOM   656  N  N    . ASP   A 1 110 ? -5.85422  -40.80109 14.94938  1.000 30.43131 ? 115  ASP   A N    1 
ATOM   657  C  CA   . ASP   A 1 110 ? -5.36124  -40.69995 16.31237  1.000 29.22396 ? 115  ASP   A CA   1 
ATOM   658  C  C    . ASP   A 1 110 ? -3.99624  -40.03296 16.21732  1.000 28.38875 ? 115  ASP   A C    1 
ATOM   659  O  O    . ASP   A 1 110 ? -3.06923  -40.58903 15.61540  1.000 34.31232 ? 115  ASP   A O    1 
ATOM   660  C  CB   . ASP   A 1 110 ? -5.28226  -42.07087 16.97453  1.000 30.36457 ? 115  ASP   A CB   1 
ATOM   661  C  CG   . ASP   A 1 110 ? -4.66128  -42.01172 18.35553  1.000 38.35216 ? 115  ASP   A CG   1 
ATOM   662  O  OD1  . ASP   A 1 110 ? -5.39429  -41.73461 19.33349  1.000 39.00233 ? 115  ASP   A OD1  1 
ATOM   663  O  OD2  . ASP   A 1 110 ? -3.43428  -42.22672 18.45057  1.000 42.64097 ? 115  ASP   A OD2  1 
ATOM   664  N  N    . VAL   A 1 111 ? -3.87324  -38.83190 16.77819  1.000 29.09156 ? 116  VAL   A N    1 
ATOM   665  C  CA   . VAL   A 1 111 ? -2.67623  -38.04394 16.49612  1.000 35.23874 ? 116  VAL   A CA   1 
ATOM   666  C  C    . VAL   A 1 111 ? -1.43725  -38.68787 17.11821  1.000 35.19757 ? 116  VAL   A C    1 
ATOM   667  O  O    . VAL   A 1 111 ? -0.38124  -38.76395 16.47924  1.000 30.94936 ? 116  VAL   A O    1 
ATOM   668  C  CB   . VAL   A 1 111 ? -2.85924  -36.58588 16.95396  1.000 39.92490 ? 116  VAL   A CB   1 
ATOM   669  C  CG1  . VAL   A 1 111 ? -3.36826  -36.52472 18.38294  1.000 42.26417 ? 116  VAL   A CG1  1 
ATOM   670  C  CG2  . VAL   A 1 111 ? -1.54223  -35.82490 16.81490  1.000 34.91420 ? 116  VAL   A CG2  1 
ATOM   671  N  N    . SER   A 1 112 ? -1.53927  -39.16573 18.36127  1.000 37.50190 ? 117  SER   A N    1 
ATOM   672  C  CA   . SER   A 1 112 ? -0.34528  -39.68266 19.03034  1.000 41.19242 ? 117  SER   A CA   1 
ATOM   673  C  C    . SER   A 1 112 ? 0.20373   -40.91374 18.31549  1.000 31.07802 ? 117  SER   A C    1 
ATOM   674  O  O    . SER   A 1 112 ? 1.41873   -41.04777 18.15252  1.000 39.48359 ? 117  SER   A O    1 
ATOM   675  C  CB   . SER   A 1 112 ? -0.64731  -39.98450 20.49937  1.000 39.74603 ? 117  SER   A CB   1 
ATOM   676  O  OG   . SER   A 1 112 ? -1.63131  -40.99348 20.62547  1.000 49.51541 ? 117  SER   A OG   1 
ATOM   677  N  N    . SER   A 1 113 ? -0.67127  -41.80579 17.83957  1.000 35.59032 ? 118  SER   A N    1 
ATOM   678  C  CA   . SER   A 1 113 ? -0.20926  -42.97788 17.09771  1.000 37.82690 ? 118  SER   A CA   1 
ATOM   679  C  C    . SER   A 1 113 ? -0.09324  -42.74804 15.59868  1.000 40.35155 ? 118  SER   A C    1 
ATOM   680  O  O    . SER   A 1 113 ? 0.51777   -43.57012 14.90978  1.000 36.54797 ? 118  SER   A O    1 
ATOM   681  C  CB   . SER   A 1 113 ? -1.14527  -44.16585 17.31982  1.000 41.10278 ? 118  SER   A CB   1 
ATOM   682  O  OG   . SER   A 1 113 ? -2.29226  -44.06394 16.48879  1.000 35.81561 ? 118  SER   A OG   1 
ATOM   683  N  N    . GLY   A 1 114 ? -0.68923  -41.67710 15.07156  1.000 37.93394 ? 119  GLY   A N    1 
ATOM   684  C  CA   . GLY   A 1 114 ? -0.65920  -41.44526 13.64053  1.000 34.25302 ? 119  GLY   A CA   1 
ATOM   685  C  C    . GLY   A 1 114 ? -1.51619  -42.37535 12.80962  1.000 33.95200 ? 119  GLY   A C    1 
ATOM   686  O  O    . GLY   A 1 114 ? -1.43117  -42.33848 11.57862  1.000 36.72502 ? 119  GLY   A O    1 
ATOM   687  N  N    . LYS   A 1 115 ? -2.35121  -43.20027 13.43170  1.000 34.50304 ? 120  LYS   A N    1 
ATOM   688  C  CA   . LYS   A 1 115 ? -3.12420  -44.18335 12.69179  1.000 36.02364 ? 120  LYS   A CA   1 
ATOM   689  C  C    . LYS   A 1 115 ? -4.46319  -43.61340 12.24171  1.000 28.68650 ? 120  LYS   A C    1 
ATOM   690  O  O    . LYS   A 1 115 ? -5.07020  -42.78432 12.92461  1.000 26.53230 ? 120  LYS   A O    1 
ATOM   691  C  CB   . LYS   A 1 115 ? -3.35422  -45.43526 13.53993  1.000 35.37845 ? 120  LYS   A CB   1 
ATOM   692  C  CG   . LYS   A 1 115 ? -2.05323  -46.09421 14.02002  1.000 46.73634 ? 120  LYS   A CG   1 
ATOM   693  C  CD   . LYS   A 1 115 ? -2.16923  -47.61520 14.08619  1.000 52.32981 ? 120  LYS   A CD   1 
ATOM   694  C  CE   . LYS   A 1 115 ? -0.82024  -48.27618 14.37728  1.000 54.68553 ? 120  LYS   A CE   1 
ATOM   695  N  NZ   . LYS   A 1 115 ? -0.39626  -48.07302 15.79527  1.000 59.72657 ? 120  LYS   A NZ   1 
ATOM   696  N  N    . CYS   A 1 116 ? -4.92817  -44.08752 11.08376  1.000 31.44582 ? 121  CYS   A N    1 
ATOM   697  C  CA   . CYS   A 1 116 ? -6.26516  -43.77057 10.58470  1.000 31.18673 ? 121  CYS   A CA   1 
ATOM   698  C  C    . CYS   A 1 116 ? -7.29318  -44.65449 11.29278  1.000 32.50615 ? 121  CYS   A C    1 
ATOM   699  O  O    . CYS   A 1 116 ? -7.32118  -45.87351 11.09891  1.000 30.58622 ? 121  CYS   A O    1 
ATOM   700  C  CB   . CYS   A 1 116 ? -6.32514  -43.96374 9.07172   1.000 30.54222 ? 121  CYS   A CB   1 
ATOM   701  S  SG   . CYS   A 1 116 ? -7.98213  -43.72681 8.41467   1.000 33.41726 ? 121  CYS   A SG   1 
ATOM   702  N  N    . LEU   A 1 117 ? -8.14319  -44.03840 12.11070  1.000 29.46413 ? 122  LEU   A N    1 
ATOM   703  C  CA   . LEU   A 1 117 ? -9.18320  -44.77832 12.82076  1.000 32.04264 ? 122  LEU   A CA   1 
ATOM   704  C  C    . LEU   A 1 117 ? -10.39119 -45.05041 11.93377  1.000 39.28694 ? 122  LEU   A C    1 
ATOM   705  O  O    . LEU   A 1 117 ? -10.98019 -46.13740 11.99789  1.000 34.24177 ? 122  LEU   A O    1 
ATOM   706  C  CB   . LEU   A 1 117 ? -9.62422  -44.00418 14.05667  1.000 34.27485 ? 122  LEU   A CB   1 
ATOM   707  C  CG   . LEU   A 1 117 ? -8.53523  -43.65307 15.06865  1.000 31.77324 ? 122  LEU   A CG   1 
ATOM   708  C  CD1  . LEU   A 1 117 ? -9.15825  -42.94794 16.26956  1.000 32.89642 ? 122  LEU   A CD1  1 
ATOM   709  C  CD2  . LEU   A 1 117 ? -7.75224  -44.90103 15.48780  1.000 34.86950 ? 122  LEU   A CD2  1 
ATOM   710  N  N    . LYS   A 1 118 ? -10.79217 -44.07650 11.11966  1.000 27.63800 ? 123  LYS   A N    1 
ATOM   711  C  CA   . LYS   A 1 118 ? -11.95316 -44.25159 10.26166  1.000 28.58685 ? 123  LYS   A CA   1 
ATOM   712  C  C    . LYS   A 1 118 ? -11.71814 -43.51573 8.95258   1.000 29.24405 ? 123  LYS   A C    1 
ATOM   713  O  O    . LYS   A 1 118 ? -11.05913 -42.47374 8.91948   1.000 27.07924 ? 123  LYS   A O    1 
ATOM   714  C  CB   . LYS   A 1 118 ? -13.23317 -43.72651 10.93458  1.000 28.35877 ? 123  LYS   A CB   1 
ATOM   715  C  CG   . LYS   A 1 118 ? -13.57919 -44.35936 12.28465  1.000 33.33079 ? 123  LYS   A CG   1 
ATOM   716  C  CD   . LYS   A 1 118 ? -14.21219 -45.71838 12.07479  1.000 40.94198 ? 123  LYS   A CD   1 
ATOM   717  C  CE   . LYS   A 1 118 ? -14.77922 -46.26924 13.36584  1.000 45.61215 ? 123  LYS   A CE   1 
ATOM   718  N  NZ   . LYS   A 1 118 ? -15.39222 -47.59826 13.14698  1.000 48.99734 ? 123  LYS   A NZ   1 
ATOM   719  N  N    . THR   A 1 119 ? -12.28312 -44.05485 7.87663   1.000 30.11950 ? 124  THR   A N    1 
ATOM   720  C  CA   . THR   A 1 119 ? -12.36510 -43.37199 6.59256   1.000 26.67836 ? 124  THR   A CA   1 
ATOM   721  C  C    . THR   A 1 119 ? -13.84009 -43.13802 6.28251   1.000 32.18173 ? 124  THR   A C    1 
ATOM   722  O  O    . THR   A 1 119 ? -14.61809 -44.09603 6.21060   1.000 27.23023 ? 124  THR   A O    1 
ATOM   723  C  CB   . THR   A 1 119 ? -11.67408 -44.19012 5.50266   1.000 26.55377 ? 124  THR   A CB   1 
ATOM   724  O  OG1  . THR   A 1 119 ? -10.29609 -44.34508 5.85770   1.000 27.04021 ? 124  THR   A OG1  1 
ATOM   725  C  CG2  . THR   A 1 119 ? -11.75106 -43.48027 4.14658   1.000 27.48922 ? 124  THR   A CG2  1 
ATOM   726  N  N    . LEU   A 1 120 ? -14.23008 -41.86603 6.14736   1.000 27.05789 ? 125  LEU   A N    1 
ATOM   727  C  CA   . LEU   A 1 120 ? -15.62808 -41.48705 5.93730   1.000 27.24508 ? 125  LEU   A CA   1 
ATOM   728  C  C    . LEU   A 1 120 ? -15.88806 -41.40222 4.43928   1.000 31.06065 ? 125  LEU   A C    1 
ATOM   729  O  O    . LEU   A 1 120 ? -15.35904 -40.52030 3.74720   1.000 29.82195 ? 125  LEU   A O    1 
ATOM   730  C  CB   . LEU   A 1 120 ? -15.94909 -40.15998 6.63015   1.000 24.02402 ? 125  LEU   A CB   1 
ATOM   731  C  CG   . LEU   A 1 120 ? -15.39511 -39.96282 8.05413   1.000 32.38903 ? 125  LEU   A CG   1 
ATOM   732  C  CD1  . LEU   A 1 120 ? -15.90711 -38.67175 8.70598   1.000 27.75939 ? 125  LEU   A CD1  1 
ATOM   733  C  CD2  . LEU   A 1 120 ? -15.65813 -41.14772 8.94426   1.000 32.57183 ? 125  LEU   A CD2  1 
ATOM   734  N  N    . LYS   A 1 121 ? -16.69905 -42.31827 3.93437   1.000 27.46396 ? 126  LYS   A N    1 
ATOM   735  C  CA   . LYS   A 1 121 ? -16.99303 -42.40743 2.51538   1.000 31.21696 ? 126  LYS   A CA   1 
ATOM   736  C  C    . LYS   A 1 121 ? -18.45202 -42.06144 2.29432   1.000 28.57115 ? 126  LYS   A C    1 
ATOM   737  O  O    . LYS   A 1 121 ? -19.32104 -42.47336 3.06735   1.000 33.23059 ? 126  LYS   A O    1 
ATOM   738  C  CB   . LYS   A 1 121 ? -16.70303 -43.80649 1.97554   1.000 33.26004 ? 126  LYS   A CB   1 
ATOM   739  C  CG   . LYS   A 1 121 ? -15.24403 -44.21748 2.08661   1.000 33.42990 ? 126  LYS   A CG   1 
ATOM   740  C  CD   . LYS   A 1 121 ? -15.05503 -45.68152 1.68677   1.000 35.78361 ? 126  LYS   A CD   1 
ATOM   741  C  CE   . LYS   A 1 121 ? -13.59603 -46.12352 1.82084   1.000 47.57021 ? 126  LYS   A CE   1 
ATOM   742  N  NZ   . LYS   A 1 121 ? -13.34303 -47.45159 1.17999   1.000 46.53734 ? 126  LYS   A NZ   1 
ATOM   743  N  N    . GLY   A 1 122 ? -18.71500 -41.30456 1.23923   1.000 27.41045 ? 127  GLY   A N    1 
ATOM   744  C  CA   . GLY   A 1 122 ? -20.05800 -40.84058 0.99516   1.000 29.02793 ? 127  GLY   A CA   1 
ATOM   745  C  C    . GLY   A 1 122 ? -20.10398 -39.72169 -0.01897  1.000 30.44647 ? 127  GLY   A C    1 
ATOM   746  O  O    . GLY   A 1 122 ? -20.93996 -39.74179 -0.92498  1.000 28.16212 ? 127  GLY   A O    1 
ATOM   747  N  N    . HIS   A 1 123 ? -19.23498 -38.72368 0.13493   1.000 28.15158 ? 128  HIS   A N    1 
ATOM   748  C  CA   . HIS   A 1 123 ? -19.18096 -37.65079 -0.84618  1.000 24.83285 ? 128  HIS   A CA   1 
ATOM   749  C  C    . HIS   A 1 123 ? -18.84994 -38.21194 -2.22712  1.000 24.00961 ? 128  HIS   A C    1 
ATOM   750  O  O    . HIS   A 1 123 ? -18.11794 -39.19896 -2.37199  1.000 26.43229 ? 128  HIS   A O    1 
ATOM   751  C  CB   . HIS   A 1 123 ? -18.13996 -36.61175 -0.44528  1.000 24.10201 ? 128  HIS   A CB   1 
ATOM   752  C  CG   . HIS   A 1 123 ? -18.59397 -35.67963 0.63761   1.000 28.88570 ? 128  HIS   A CG   1 
ATOM   753  N  ND1  . HIS   A 1 123 ? -19.64097 -34.79764 0.47149   1.000 22.66033 ? 128  HIS   A ND1  1 
ATOM   754  C  CD2  . HIS   A 1 123 ? -18.12199 -35.47549 1.89259   1.000 20.91723 ? 128  HIS   A CD2  1 
ATOM   755  C  CE1  . HIS   A 1 123 ? -19.79998 -34.09552 1.58241   1.000 23.26925 ? 128  HIS   A CE1  1 
ATOM   756  N  NE2  . HIS   A 1 123 ? -18.89100 -34.48842 2.45847   1.000 21.66719 ? 128  HIS   A NE2  1 
ATOM   757  N  N    . SER   A 1 124 ? -19.40392 -37.57505 -3.24919  1.000 24.92110 ? 129  SER   A N    1 
ATOM   758  C  CA   . SER   A 1 124 ? -19.21290 -38.02520 -4.61514  1.000 28.99760 ? 129  SER   A CA   1 
ATOM   759  C  C    . SER   A 1 124 ? -18.13988 -37.22629 -5.33621  1.000 29.03819 ? 129  SER   A C    1 
ATOM   760  O  O    . SER   A 1 124 ? -17.92787 -37.42942 -6.53319  1.000 26.07085 ? 129  SER   A O    1 
ATOM   761  C  CB   . SER   A 1 124 ? -20.54689 -37.96728 -5.37217  1.000 27.63067 ? 129  SER   A CB   1 
ATOM   762  O  OG   . SER   A 1 124 ? -21.07188 -36.65528 -5.39732  1.000 27.51966 ? 129  SER   A OG   1 
ATOM   763  N  N    . ASN   A 1 125 ? -17.44389 -36.34021 -4.63030  1.000 24.99794 ? 130  ASN   A N    1 
ATOM   764  C  CA   . ASN   A 1 125 ? -16.38988 -35.53628 -5.23237  1.000 25.85832 ? 130  ASN   A CA   1 
ATOM   765  C  C    . ASN   A 1 125 ? -15.54890 -34.94016 -4.10742  1.000 25.20602 ? 130  ASN   A C    1 
ATOM   766  O  O    . ASN   A 1 125 ? -15.77392 -35.22503 -2.92840  1.000 22.25334 ? 130  ASN   A O    1 
ATOM   767  C  CB   . ASN   A 1 125 ? -16.97286 -34.45938 -6.15950  1.000 22.67339 ? 130  ASN   A CB   1 
ATOM   768  C  CG   . ASN   A 1 125 ? -16.12084 -34.25752 -7.40251  1.000 29.98878 ? 130  ASN   A CG   1 
ATOM   769  O  OD1  . ASN   A 1 125 ? -14.89984 -34.41552 -7.35047  1.000 27.92638 ? 130  ASN   A OD1  1 
ATOM   770  N  ND2  . ASN   A 1 125 ? -16.75682 -33.92165 -8.52356  1.000 26.79588 ? 130  ASN   A ND2  1 
ATOM   771  N  N    . TYR   A 1 126 ? -14.56589 -34.11521 -4.48050  1.000 22.65570 ? 131  TYR   A N    1 
ATOM   772  C  CA   . TYR   A 1 126 ? -13.57790 -33.63710 -3.51354  1.000 24.52573 ? 131  TYR   A CA   1 
ATOM   773  C  C    . TYR   A 1 126 ? -14.23892 -33.08796 -2.25461  1.000 22.28699 ? 131  TYR   A C    1 
ATOM   774  O  O    . TYR   A 1 126 ? -15.21191 -32.33997 -2.32671  1.000 21.33492 ? 131  TYR   A O    1 
ATOM   775  C  CB   . TYR   A 1 126 ? -12.71889 -32.52017 -4.10765  1.000 26.26323 ? 131  TYR   A CB   1 
ATOM   776  C  CG   . TYR   A 1 126 ? -12.48086 -32.60834 -5.58163  1.000 25.90520 ? 131  TYR   A CG   1 
ATOM   777  C  CD1  . TYR   A 1 126 ? -11.58986 -33.54540 -6.10652  1.000 25.67681 ? 131  TYR   A CD1  1 
ATOM   778  C  CD2  . TYR   A 1 126 ? -13.11385 -31.73143 -6.45374  1.000 27.04720 ? 131  TYR   A CD2  1 
ATOM   779  C  CE1  . TYR   A 1 126 ? -11.34884 -33.61755 -7.46850  1.000 34.66499 ? 131  TYR   A CE1  1 
ATOM   780  C  CE2  . TYR   A 1 126 ? -12.87782 -31.79258 -7.82273  1.000 31.28224 ? 131  TYR   A CE2  1 
ATOM   781  C  CZ   . TYR   A 1 126 ? -11.99582 -32.74464 -8.32061  1.000 35.30935 ? 131  TYR   A CZ   1 
ATOM   782  O  OH   . TYR   A 1 126 ? -11.76480 -32.82579 -9.67160  1.000 37.18587 ? 131  TYR   A OH   1 
ATOM   783  N  N    . VAL   A 1 127 ? -13.65794 -33.41184 -1.10056  1.000 20.35935 ? 132  VAL   A N    1 
ATOM   784  C  CA   . VAL   A 1 127 ? -14.06596 -32.84769 0.17837   1.000 21.29565 ? 132  VAL   A CA   1 
ATOM   785  C  C    . VAL   A 1 127 ? -13.14396 -31.67766 0.49825   1.000 25.30126 ? 132  VAL   A C    1 
ATOM   786  O  O    . VAL   A 1 127 ? -11.91696 -31.82767 0.49329   1.000 21.96167 ? 132  VAL   A O    1 
ATOM   787  C  CB   . VAL   A 1 127 ? -14.02198 -33.91057 1.28849   1.000 21.31597 ? 132  VAL   A CB   1 
ATOM   788  C  CG1  . VAL   A 1 127 ? -14.81099 -33.44344 2.49042   1.000 20.11330 ? 132  VAL   A CG1  1 
ATOM   789  C  CG2  . VAL   A 1 127 ? -14.53697 -35.25763 0.76863   1.000 23.96162 ? 132  VAL   A CG2  1 
ATOM   790  N  N    . PHE   A 1 128 ? -13.72696 -30.50363 0.76111   1.000 21.15207 ? 133  PHE   A N    1 
ATOM   791  C  CA   . PHE   A 1 128 ? -12.93695 -29.28262 0.91799   1.000 23.57686 ? 133  PHE   A CA   1 
ATOM   792  C  C    . PHE   A 1 128 ? -12.78298 -28.82646 2.36094   1.000 22.09387 ? 133  PHE   A C    1 
ATOM   793  O  O    . PHE   A 1 128 ? -11.81398 -28.11843 2.66988   1.000 20.78960 ? 133  PHE   A O    1 
ATOM   794  C  CB   . PHE   A 1 128 ? -13.55594 -28.12570 0.11986   1.000 19.78818 ? 133  PHE   A CB   1 
ATOM   795  C  CG   . PHE   A 1 128 ? -13.41391 -28.26287 -1.37413  1.000 19.52576 ? 133  PHE   A CG   1 
ATOM   796  C  CD1  . PHE   A 1 128 ? -12.27591 -28.82393 -1.93205  1.000 22.79438 ? 133  PHE   A CD1  1 
ATOM   797  C  CD2  . PHE   A 1 128 ? -14.42290 -27.82396 -2.21819  1.000 21.26716 ? 133  PHE   A CD2  1 
ATOM   798  C  CE1  . PHE   A 1 128 ? -12.14889 -28.94509 -3.31403  1.000 24.84866 ? 133  PHE   A CE1  1 
ATOM   799  C  CE2  . PHE   A 1 128 ? -14.30188 -27.93211 -3.60518  1.000 23.67938 ? 133  PHE   A CE2  1 
ATOM   800  C  CZ   . PHE   A 1 128 ? -13.17687 -28.49018 -4.15410  1.000 26.30394 ? 133  PHE   A CZ   1 
ATOM   801  N  N    . CYS   A 1 129 ? -13.70599 -29.18736 3.24697   1.000 21.08722 ? 134  CYS   A N    1 
ATOM   802  C  CA   . CYS   A 1 129 ? -13.73901 -28.55321 4.55490   1.000 19.05893 ? 134  CYS   A CA   1 
ATOM   803  C  C    . CYS   A 1 129 ? -14.27503 -29.54010 5.58100   1.000 21.15603 ? 134  CYS   A C    1 
ATOM   804  O  O    . CYS   A 1 129 ? -15.08803 -30.41113 5.25808   1.000 18.32323 ? 134  CYS   A O    1 
ATOM   805  C  CB   . CYS   A 1 129 ? -14.59800 -27.27321 4.52174   1.000 19.05951 ? 134  CYS   A CB   1 
ATOM   806  S  SG   . CYS   A 1 129 ? -16.25599 -27.40430 3.64473   1.000 21.31204 ? 134  CYS   A SG   1 
ATOM   807  N  N    . CYS   A 1 130 ? -13.81905 -29.39696 6.82399   1.000 19.54463 ? 135  CYS   A N    1 
ATOM   808  C  CA   . CYS   A 1 130 ? -14.25007 -30.32585 7.86409   1.000 21.74625 ? 135  CYS   A CA   1 
ATOM   809  C  C    . CYS   A 1 130 ? -14.07609 -29.68570 9.22702   1.000 23.32407 ? 135  CYS   A C    1 
ATOM   810  O  O    . CYS   A 1 130 ? -13.31509 -28.72968 9.39393   1.000 22.14043 ? 135  CYS   A O    1 
ATOM   811  C  CB   . CYS   A 1 130 ? -13.47607 -31.64386 7.79924   1.000 23.88574 ? 135  CYS   A CB   1 
ATOM   812  S  SG   . CYS   A 1 130 ? -11.67607 -31.42887 7.74725   1.000 24.30114 ? 135  CYS   A SG   1 
ATOM   813  N  N    . ASN   A 1 131 ? -14.77311 -30.25258 10.21207  1.000 22.60461 ? 136  ASN   A N    1 
ATOM   814  C  CA   . ASN   A 1 131 ? -14.70913 -29.75043 11.57902  1.000 23.07317 ? 136  ASN   A CA   1 
ATOM   815  C  C    . ASN   A 1 131 ? -15.39414 -30.74033 12.50411  1.000 27.26637 ? 136  ASN   A C    1 
ATOM   816  O  O    . ASN   A 1 131 ? -16.38614 -31.36437 12.10817  1.000 22.08511 ? 136  ASN   A O    1 
ATOM   817  C  CB   . ASN   A 1 131 ? -15.38912 -28.38342 11.68085  1.000 21.51299 ? 136  ASN   A CB   1 
ATOM   818  C  CG   . ASN   A 1 131 ? -14.40512 -27.26241 11.76175  1.000 28.48054 ? 136  ASN   A CG   1 
ATOM   819  O  OD1  . ASN   A 1 131 ? -13.41213 -27.35634 12.48177  1.000 27.52747 ? 136  ASN   A OD1  1 
ATOM   820  N  ND2  . ASN   A 1 131 ? -14.65710 -26.18550 11.01062  1.000 22.08058 ? 136  ASN   A ND2  1 
ATOM   821  N  N    . PHE   A 1 132 ? -14.85216 -30.89620 13.72214  1.000 24.34193 ? 137  PHE   A N    1 
ATOM   822  C  CA   . PHE   A 1 132 ? -15.58018 -31.58108 14.79020  1.000 23.51601 ? 137  PHE   A CA   1 
ATOM   823  C  C    . PHE   A 1 132 ? -16.58119 -30.63000 15.42208  1.000 23.01248 ? 137  PHE   A C    1 
ATOM   824  O  O    . PHE   A 1 132 ? -16.37119 -29.41600 15.44295  1.000 23.18928 ? 137  PHE   A O    1 
ATOM   825  C  CB   . PHE   A 1 132 ? -14.64720 -32.05696 15.90727  1.000 23.11598 ? 137  PHE   A CB   1 
ATOM   826  C  CG   . PHE   A 1 132 ? -13.77220 -33.21400 15.53841  1.000 25.57130 ? 137  PHE   A CG   1 
ATOM   827  C  CD1  . PHE   A 1 132 ? -12.52019 -33.00107 14.97141  1.000 24.10373 ? 137  PHE   A CD1  1 
ATOM   828  C  CD2  . PHE   A 1 132 ? -14.18021 -34.51197 15.78855  1.000 24.49995 ? 137  PHE   A CD2  1 
ATOM   829  C  CE1  . PHE   A 1 132 ? -11.69819 -34.06511 14.64654  1.000 24.94001 ? 137  PHE   A CE1  1 
ATOM   830  C  CE2  . PHE   A 1 132 ? -13.36021 -35.58901 15.46468  1.000 26.37567 ? 137  PHE   A CE2  1 
ATOM   831  C  CZ   . PHE   A 1 132 ? -12.11420 -35.36308 14.89468  1.000 25.68544 ? 137  PHE   A CZ   1 
ATOM   832  N  N    . ASN   A 1 133 ? -17.64220 -31.18593 16.00213  1.000 21.03435 ? 138  ASN   A N    1 
ATOM   833  C  CA   . ASN   A 1 133 ? -18.42621 -30.36483 16.91302  1.000 28.60158 ? 138  ASN   A CA   1 
ATOM   834  C  C    . ASN   A 1 133 ? -17.70323 -30.26569 18.25003  1.000 26.66928 ? 138  ASN   A C    1 
ATOM   835  O  O    . ASN   A 1 133 ? -16.74924 -30.99866 18.51112  1.000 31.73079 ? 138  ASN   A O    1 
ATOM   836  C  CB   . ASN   A 1 133 ? -19.84922 -30.91781 17.05806  1.000 26.88322 ? 138  ASN   A CB   1 
ATOM   837  C  CG   . ASN   A 1 133 ? -19.90723 -32.29674 17.68121  1.000 28.79111 ? 138  ASN   A CG   1 
ATOM   838  O  OD1  . ASN   A 1 133 ? -18.91424 -33.02774 17.73731  1.000 26.33714 ? 138  ASN   A OD1  1 
ATOM   839  N  ND2  . ASN   A 1 133 ? -21.10924 -32.67769 18.13224  1.000 27.29539 ? 138  ASN   A ND2  1 
ATOM   840  N  N    . PRO   A 1 134 ? -18.11224 -29.33359 19.11492  1.000 25.54299 ? 139  PRO   A N    1 
ATOM   841  C  CA   . PRO   A 1 134 ? -17.43026 -29.21245 20.41491  1.000 29.98734 ? 139  PRO   A CA   1 
ATOM   842  C  C    . PRO   A 1 134 ? -17.49728 -30.48736 21.23805  1.000 34.34463 ? 139  PRO   A C    1 
ATOM   843  O  O    . PRO   A 1 134 ? -16.52429 -30.83828 21.91711  1.000 28.50615 ? 139  PRO   A O    1 
ATOM   844  C  CB   . PRO   A 1 134 ? -18.17527 -28.05037 21.08877  1.000 33.62770 ? 139  PRO   A CB   1 
ATOM   845  C  CG   . PRO   A 1 134 ? -18.72825 -27.24849 19.94368  1.000 28.73904 ? 139  PRO   A CG   1 
ATOM   846  C  CD   . PRO   A 1 134 ? -19.13324 -28.28860 18.93078  1.000 28.42355 ? 139  PRO   A CD   1 
ATOM   847  N  N    . GLN   A 1 135 ? -18.62928 -31.19236 21.18711  1.000 26.83933 ? 140  GLN   A N    1 
ATOM   848  C  CA   . GLN   A 1 135 ? -18.74830 -32.48528 21.85125  1.000 27.58078 ? 140  GLN   A CA   1 
ATOM   849  C  C    . GLN   A 1 135 ? -17.80929 -33.51835 21.24538  1.000 34.08401 ? 140  GLN   A C    1 
ATOM   850  O  O    . GLN   A 1 135 ? -17.46831 -34.50128 21.91250  1.000 35.59260 ? 140  GLN   A O    1 
ATOM   851  C  CB   . GLN   A 1 135 ? -20.20130 -32.98429 21.77129  1.000 31.93324 ? 140  GLN   A CB   1 
ATOM   852  C  CG   . GLN   A 1 135 ? -21.22331 -32.08820 22.49617  1.000 39.10278 ? 140  GLN   A CG   1 
ATOM   853  C  CD   . GLN   A 1 135 ? -21.56929 -30.75728 21.76202  1.000 46.77471 ? 140  GLN   A CD   1 
ATOM   854  O  OE1  . GLN   A 1 135 ? -21.27327 -30.56542 20.56000  1.000 28.07220 ? 140  GLN   A OE1  1 
ATOM   855  N  NE2  . GLN   A 1 135 ? -22.20830 -29.83720 22.50091  1.000 43.54188 ? 140  GLN   A NE2  1 
ATOM   856  N  N    . SER   A 1 136 ? -17.39027 -33.31549 19.99737  1.000 27.62890 ? 141  SER   A N    1 
ATOM   857  C  CA   . SER   A 1 136 ? -16.46126 -34.18658 19.28748  1.000 28.15254 ? 141  SER   A CA   1 
ATOM   858  C  C    . SER   A 1 136 ? -17.02927 -35.57360 19.02962  1.000 29.56040 ? 141  SER   A C    1 
ATOM   859  O  O    . SER   A 1 136 ? -16.27427 -36.52562 18.85674  1.000 29.26457 ? 141  SER   A O    1 
ATOM   860  C  CB   . SER   A 1 136 ? -15.12428 -34.27750 20.02851  1.000 33.79376 ? 141  SER   A CB   1 
ATOM   861  O  OG   . SER   A 1 136 ? -14.41227 -33.05152 19.85639  1.000 39.23478 ? 141  SER   A OG   1 
ATOM   862  N  N    . ASN   A 1 137 ? -18.35227 -35.72060 18.98462  1.000 23.94343 ? 142  ASN   A N    1 
ATOM   863  C  CA   . ASN   A 1 137 ? -18.94526 -36.97665 18.54875  1.000 27.22153 ? 142  ASN   A CA   1 
ATOM   864  C  C    . ASN   A 1 137 ? -19.47824 -36.89280 17.12973  1.000 26.65600 ? 142  ASN   A C    1 
ATOM   865  O  O    . ASN   A 1 137 ? -19.90824 -37.91386 16.57983  1.000 28.31272 ? 142  ASN   A O    1 
ATOM   866  C  CB   . ASN   A 1 137 ? -20.05228 -37.42254 19.52178  1.000 26.80579 ? 142  ASN   A CB   1 
ATOM   867  C  CG   . ASN   A 1 137 ? -21.05028 -36.31150 19.84064  1.000 31.70974 ? 142  ASN   A CG   1 
ATOM   868  O  OD1  . ASN   A 1 137 ? -21.09727 -35.29457 19.15453  1.000 34.51409 ? 142  ASN   A OD1  1 
ATOM   869  N  ND2  . ASN   A 1 137 ? -21.86230 -36.50938 20.88665  1.000 27.32942 ? 142  ASN   A ND2  1 
ATOM   870  N  N    . LEU   A 1 138 ? -19.43223 -35.70787 16.52060  1.000 25.92743 ? 143  LEU   A N    1 
ATOM   871  C  CA   . LEU   A 1 138 ? -19.82720 -35.50002 15.13757  1.000 24.79361 ? 143  LEU   A CA   1 
ATOM   872  C  C    . LEU   A 1 138 ? -18.69819 -34.81911 14.36851  1.000 25.82210 ? 143  LEU   A C    1 
ATOM   873  O  O    . LEU   A 1 138 ? -17.90520 -34.06005 14.93244  1.000 24.98784 ? 143  LEU   A O    1 
ATOM   874  C  CB   . LEU   A 1 138 ? -21.09220 -34.61703 15.02745  1.000 25.41641 ? 143  LEU   A CB   1 
ATOM   875  C  CG   . LEU   A 1 138 ? -22.38721 -35.02395 15.72648  1.000 25.89148 ? 143  LEU   A CG   1 
ATOM   876  C  CD1  . LEU   A 1 138 ? -23.46720 -33.93797 15.50534  1.000 23.42141 ? 143  LEU   A CD1  1 
ATOM   877  C  CD2  . LEU   A 1 138 ? -22.86821 -36.36800 15.19862  1.000 22.52112 ? 143  LEU   A CD2  1 
ATOM   878  N  N    . ILE   A 1 139 ? -18.65117 -35.09125 13.06754  1.000 26.03197 ? 144  ILE   A N    1 
ATOM   879  C  CA   . ILE   A 1 139 ? -17.86215 -34.32436 12.11047  1.000 23.34670 ? 144  ILE   A CA   1 
ATOM   880  C  C    . ILE   A 1 139 ? -18.81913 -33.78348 11.05640  1.000 24.62827 ? 144  ILE   A C    1 
ATOM   881  O  O    . ILE   A 1 139 ? -19.75813 -34.47752 10.65546  1.000 24.37367 ? 144  ILE   A O    1 
ATOM   882  C  CB   . ILE   A 1 139 ? -16.77514 -35.20244 11.46459  1.000 28.25398 ? 144  ILE   A CB   1 
ATOM   883  C  CG1  . ILE   A 1 139 ? -15.65516 -35.47533 12.46863  1.000 23.23385 ? 144  ILE   A CG1  1 
ATOM   884  C  CG2  . ILE   A 1 139 ? -16.27812 -34.58759 10.13853  1.000 26.78167 ? 144  ILE   A CG2  1 
ATOM   885  C  CD1  . ILE   A 1 139 ? -14.84416 -36.70738 12.10078  1.000 25.91007 ? 144  ILE   A CD1  1 
ATOM   886  N  N    . VAL   A 1 140 ? -18.59912 -32.54052 10.62826  1.000 21.95926 ? 145  VAL   A N    1 
ATOM   887  C  CA   . VAL   A 1 140 ? -19.34010 -31.93864 9.52218   1.000 21.97226 ? 145  VAL   A CA   1 
ATOM   888  C  C    . VAL   A 1 140 ? -18.36208 -31.74977 8.36618   1.000 22.23420 ? 145  VAL   A C    1 
ATOM   889  O  O    . VAL   A 1 140 ? -17.18508 -31.44675 8.59216   1.000 21.32148 ? 145  VAL   A O    1 
ATOM   890  C  CB   . VAL   A 1 140 ? -19.99810 -30.60659 9.94003   1.000 20.21099 ? 145  VAL   A CB   1 
ATOM   891  C  CG1  . VAL   A 1 140 ? -18.94710 -29.56056 10.30093  1.000 17.98538 ? 145  VAL   A CG1  1 
ATOM   892  C  CG2  . VAL   A 1 140 ? -20.93908 -30.08871 8.85195   1.000 20.82765 ? 145  VAL   A CG2  1 
ATOM   893  N  N    . SER   A 1 141 ? -18.82906 -31.98291 7.13920   1.000 18.00749 ? 146  SER   A N    1 
ATOM   894  C  CA   . SER   A 1 141 ? -17.96404 -31.87804 5.97320   1.000 21.43657 ? 146  SER   A CA   1 
ATOM   895  C  C    . SER   A 1 141 ? -18.70502 -31.15816 4.85811   1.000 20.98492 ? 146  SER   A C    1 
ATOM   896  O  O    . SER   A 1 141 ? -19.93702 -31.17116 4.81409   1.000 21.26449 ? 146  SER   A O    1 
ATOM   897  C  CB   . SER   A 1 141 ? -17.49704 -33.25510 5.48236   1.000 23.15322 ? 146  SER   A CB   1 
ATOM   898  O  OG   . SER   A 1 141 ? -18.60104 -34.03814 5.05043   1.000 22.38510 ? 146  SER   A OG   1 
ATOM   899  N  N    . GLY   A 1 142 ? -17.94101 -30.49426 3.99005   1.000 19.13814 ? 147  GLY   A N    1 
ATOM   900  C  CA   . GLY   A 1 142 ? -18.49599 -29.86339 2.80397   1.000 19.26899 ? 147  GLY   A CA   1 
ATOM   901  C  C    . GLY   A 1 142 ? -17.66197 -30.22753 1.58902   1.000 18.27740 ? 147  GLY   A C    1 
ATOM   902  O  O    . GLY   A 1 142 ? -16.45997 -30.48052 1.69107   1.000 19.43091 ? 147  GLY   A O    1 
ATOM   903  N  N    . SER   A 1 143 ? -18.31495 -30.25465 0.42601   1.000 18.91211 ? 148  SER   A N    1 
ATOM   904  C  CA   . SER   A 1 143 ? -17.74793 -30.91878 -0.74490  1.000 21.75104 ? 148  SER   A CA   1 
ATOM   905  C  C    . SER   A 1 143 ? -18.06291 -30.16392 -2.02999  1.000 24.45680 ? 148  SER   A C    1 
ATOM   906  O  O    . SER   A 1 143 ? -19.05291 -29.42593 -2.13209  1.000 19.36027 ? 148  SER   A O    1 
ATOM   907  C  CB   . SER   A 1 143 ? -18.26694 -32.36879 -0.86175  1.000 21.79042 ? 148  SER   A CB   1 
ATOM   908  O  OG   . SER   A 1 143 ? -17.83492 -33.00293 -2.05567  1.000 22.58506 ? 148  SER   A OG   1 
ATOM   909  N  N    . PHE   A 1 144 ? -17.17890 -30.36304 -3.01096  1.000 20.57618 ? 149  PHE   A N    1 
ATOM   910  C  CA   . PHE   A 1 144 ? -17.44987 -29.96119 -4.38100  1.000 17.22940 ? 149  PHE   A CA   1 
ATOM   911  C  C    . PHE   A 1 144 ? -18.79887 -30.49223 -4.85097  1.000 21.95298 ? 149  PHE   A C    1 
ATOM   912  O  O    . PHE   A 1 144 ? -19.44385 -29.87932 -5.71005  1.000 21.75475 ? 149  PHE   A O    1 
ATOM   913  C  CB   . PHE   A 1 144 ? -16.31986 -30.47129 -5.27993  1.000 20.09505 ? 149  PHE   A CB   1 
ATOM   914  C  CG   . PHE   A 1 144 ? -16.38184 -29.98645 -6.70198  1.000 21.32874 ? 149  PHE   A CG   1 
ATOM   915  C  CD1  . PHE   A 1 144 ? -15.77983 -28.78749 -7.06411  1.000 23.23434 ? 149  PHE   A CD1  1 
ATOM   916  C  CD2  . PHE   A 1 144 ? -16.99982 -30.74455 -7.68191  1.000 23.18908 ? 149  PHE   A CD2  1 
ATOM   917  C  CE1  . PHE   A 1 144 ? -15.80980 -28.33863 -8.38516  1.000 24.14595 ? 149  PHE   A CE1  1 
ATOM   918  C  CE2  . PHE   A 1 144 ? -17.04080 -30.30470 -9.01496  1.000 25.43964 ? 149  PHE   A CE2  1 
ATOM   919  C  CZ   . PHE   A 1 144 ? -16.44679 -29.09574 -9.35908  1.000 22.42045 ? 149  PHE   A CZ   1 
ATOM   920  N  N    . ASP   A 1 145 ? -19.25188 -31.62117 -4.27785  1.000 21.17082 ? 150  ASP   A N    1 
ATOM   921  C  CA   . ASP   A 1 145 ? -20.52088 -32.22821 -4.66480  1.000 20.89939 ? 150  ASP   A CA   1 
ATOM   922  C  C    . ASP   A 1 145 ? -21.72488 -31.45314 -4.14791  1.000 23.59110 ? 150  ASP   A C    1 
ATOM   923  O  O    . ASP   A 1 145 ? -22.85288 -31.88317 -4.38488  1.000 22.98698 ? 150  ASP   A O    1 
ATOM   924  C  CB   . ASP   A 1 145 ? -20.56789 -33.70716 -4.22464  1.000 21.19344 ? 150  ASP   A CB   1 
ATOM   925  C  CG   . ASP   A 1 145 ? -20.77191 -33.90599 -2.71862  1.000 24.85378 ? 150  ASP   A CG   1 
ATOM   926  O  OD1  . ASP   A 1 145 ? -21.13992 -32.95491 -1.98173  1.000 21.76750 ? 150  ASP   A OD1  1 
ATOM   927  O  OD2  . ASP   A 1 145 ? -20.54792 -35.06194 -2.27249  1.000 22.61272 ? 150  ASP   A OD2  1 
ATOM   928  N  N    . GLU   A 1 146 ? -21.51589 -30.31507 -3.48603  1.000 21.12031 ? 151  GLU   A N    1 
ATOM   929  C  CA   . GLU   A 1 146 ? -22.53089 -29.33403 -3.11815  1.000 21.74211 ? 151  GLU   A CA   1 
ATOM   930  C  C    . GLU   A 1 146 ? -23.31491 -29.77489 -1.88412  1.000 22.35050 ? 151  GLU   A C    1 
ATOM   931  O  O    . GLU   A 1 146 ? -24.27091 -29.09884 -1.50221  1.000 21.38359 ? 151  GLU   A O    1 
ATOM   932  C  CB   . GLU   A 1 146 ? -23.48987 -29.03015 -4.28920  1.000 23.31764 ? 151  GLU   A CB   1 
ATOM   933  C  CG   . GLU   A 1 146 ? -22.70785 -28.65930 -5.56723  1.000 18.90748 ? 151  GLU   A CG   1 
ATOM   934  C  CD   . GLU   A 1 146 ? -23.58383 -28.34943 -6.78928  1.000 28.50008 ? 151  GLU   A CD   1 
ATOM   935  O  OE1  . GLU   A 1 146 ? -24.82983 -28.44341 -6.70229  1.000 26.43453 ? 151  GLU   A OE1  1 
ATOM   936  O  OE2  . GLU   A 1 146 ? -23.00381 -28.02155 -7.85431  1.000 24.94442 ? 151  GLU   A OE2  1 
ATOM   937  N  N    . SER   A 1 147 ? -22.93893 -30.86882 -1.24099  1.000 22.28213 ? 152  SER   A N    1 
ATOM   938  C  CA   . SER   A 1 147 ? -23.59795 -31.31068 -0.02595  1.000 24.28053 ? 152  SER   A CA   1 
ATOM   939  C  C    . SER   A 1 147 ? -22.77196 -30.94055 1.19702   1.000 23.34057 ? 152  SER   A C    1 
ATOM   940  O  O    . SER   A 1 147 ? -21.55396 -30.73156 1.12602   1.000 19.48915 ? 152  SER   A O    1 
ATOM   941  C  CB   . SER   A 1 147 ? -23.83795 -32.83168 -0.05479  1.000 23.69470 ? 152  SER   A CB   1 
ATOM   942  O  OG   . SER   A 1 147 ? -22.63596 -33.55766 0.17631   1.000 23.92225 ? 152  SER   A OG   1 
ATOM   943  N  N    . VAL   A 1 148 ? -23.46498 -30.84642 2.32700   1.000 20.06203 ? 153  VAL   A N    1 
ATOM   944  C  CA   . VAL   A 1 148 ? -22.86200 -30.90228 3.65601   1.000 21.48504 ? 153  VAL   A CA   1 
ATOM   945  C  C    . VAL   A 1 148 ? -23.26902 -32.23321 4.27315   1.000 26.74368 ? 153  VAL   A C    1 
ATOM   946  O  O    . VAL   A 1 148 ? -24.43802 -32.63521 4.18418   1.000 24.51915 ? 153  VAL   A O    1 
ATOM   947  C  CB   . VAL   A 1 148 ? -23.31101 -29.72618 4.53388   1.000 21.09845 ? 153  VAL   A CB   1 
ATOM   948  C  CG1  . VAL   A 1 148 ? -22.84704 -29.90802 5.98490   1.000 18.73797 ? 153  VAL   A CG1  1 
ATOM   949  C  CG2  . VAL   A 1 148 ? -22.80700 -28.40724 3.96574   1.000 20.88612 ? 153  VAL   A CG2  1 
ATOM   950  N  N    . ARG   A 1 149 ? -22.31103 -32.92915 4.87425   1.000 23.88147 ? 154  ARG   A N    1 
ATOM   951  C  CA   . ARG   A 1 149 ? -22.58605 -34.21508 5.50038   1.000 22.09024 ? 154  ARG   A CA   1 
ATOM   952  C  C    . ARG   A 1 149 ? -22.18907 -34.16492 6.96238   1.000 27.49169 ? 154  ARG   A C    1 
ATOM   953  O  O    . ARG   A 1 149 ? -21.24507 -33.46188 7.34432   1.000 21.93095 ? 154  ARG   A O    1 
ATOM   954  C  CB   . ARG   A 1 149 ? -21.86004 -35.36316 4.78752   1.000 23.32236 ? 154  ARG   A CB   1 
ATOM   955  C  CG   . ARG   A 1 149 ? -22.53502 -35.78730 3.48456   1.000 29.21820 ? 154  ARG   A CG   1 
ATOM   956  C  CD   . ARG   A 1 149 ? -21.74101 -36.85138 2.75169   1.000 29.67591 ? 154  ARG   A CD   1 
ATOM   957  N  NE   . ARG   A 1 149 ? -22.41399 -37.25952 1.52172   1.000 36.68882 ? 154  ARG   A NE   1 
ATOM   958  C  CZ   . ARG   A 1 149 ? -23.12700 -38.37053 1.38583   1.000 37.79036 ? 154  ARG   A CZ   1 
ATOM   959  N  NH1  . ARG   A 1 149 ? -23.25901 -39.23642 2.38093   1.000 44.54985 ? 154  ARG   A NH1  1 
ATOM   960  N  NH2  . ARG   A 1 149 ? -23.72198 -38.61965 0.21785   1.000 31.00059 ? 154  ARG   A NH2  1 
ATOM   961  N  N    . ILE   A 1 150 ? -22.95608 -34.88882 7.77845   1.000 23.61717 ? 155  ILE   A N    1 
ATOM   962  C  CA   . ILE   A 1 150 ? -22.73611 -35.00566 9.21347   1.000 24.29112 ? 155  ILE   A CA   1 
ATOM   963  C  C    . ILE   A 1 150 ? -22.45512 -36.47363 9.51464   1.000 29.13504 ? 155  ILE   A C    1 
ATOM   964  O  O    . ILE   A 1 150 ? -23.21511 -37.35368 9.08872   1.000 25.86143 ? 155  ILE   A O    1 
ATOM   965  C  CB   . ILE   A 1 150 ? -23.94912 -34.49857 10.01639  1.000 26.82953 ? 155  ILE   A CB   1 
ATOM   966  C  CG1  . ILE   A 1 150 ? -24.27211 -33.04261 9.63623   1.000 23.91128 ? 155  ILE   A CG1  1 
ATOM   967  C  CG2  . ILE   A 1 150 ? -23.67914 -34.63241 11.51241  1.000 28.06400 ? 155  ILE   A CG2  1 
ATOM   968  C  CD1  . ILE   A 1 150 ? -25.53512 -32.47553 10.31014  1.000 27.13831 ? 155  ILE   A CD1  1 
ATOM   969  N  N    . TRP   A 1 151 ? -21.35813 -36.73256 10.23668  1.000 24.34511 ? 156  TRP   A N    1 
ATOM   970  C  CA   . TRP   A 1 151 ? -20.81814 -38.07254 10.39784  1.000 25.56191 ? 156  TRP   A CA   1 
ATOM   971  C  C    . TRP   A 1 151 ? -20.72916 -38.43238 11.86888  1.000 27.40835 ? 156  TRP   A C    1 
ATOM   972  O  O    . TRP   A 1 151 ? -20.46117 -37.57929 12.71779  1.000 23.05484 ? 156  TRP   A O    1 
ATOM   973  C  CB   . TRP   A 1 151 ? -19.40413 -38.20761 9.79388   1.000 22.69691 ? 156  TRP   A CB   1 
ATOM   974  C  CG   . TRP   A 1 151 ? -19.28010 -37.70377 8.37682   1.000 26.90541 ? 156  TRP   A CG   1 
ATOM   975  C  CD1  . TRP   A 1 151 ? -19.12909 -36.40281 7.97968   1.000 25.67269 ? 156  TRP   A CD1  1 
ATOM   976  C  CD2  . TRP   A 1 151 ? -19.27009 -38.49290 7.18291   1.000 26.63057 ? 156  TRP   A CD2  1 
ATOM   977  N  NE1  . TRP   A 1 151 ? -19.03907 -36.33497 6.60767   1.000 23.45463 ? 156  TRP   A NE1  1 
ATOM   978  C  CE2  . TRP   A 1 151 ? -19.12407 -37.60602 6.09581   1.000 28.07711 ? 156  TRP   A CE2  1 
ATOM   979  C  CE3  . TRP   A 1 151 ? -19.37409 -39.86493 6.92406   1.000 26.59399 ? 156  TRP   A CE3  1 
ATOM   980  C  CZ2  . TRP   A 1 151 ? -19.07405 -38.04817 4.77886   1.000 25.69308 ? 156  TRP   A CZ2  1 
ATOM   981  C  CZ3  . TRP   A 1 151 ? -19.34107 -40.29607 5.62111   1.000 27.76876 ? 156  TRP   A CZ3  1 
ATOM   982  C  CH2  . TRP   A 1 151 ? -19.18105 -39.39419 4.56101   1.000 25.68585 ? 156  TRP   A CH2  1 
ATOM   983  N  N    . ASP   A 1 152 ? -20.91717 -39.71635 12.15102  1.000 28.37164 ? 157  ASP   A N    1 
ATOM   984  C  CA   . ASP   A 1 152 ? -20.72720 -40.24520 13.49708  1.000 29.91858 ? 157  ASP   A CA   1 
ATOM   985  C  C    . ASP   A 1 152 ? -19.24220 -40.53818 13.69914  1.000 25.07629 ? 157  ASP   A C    1 
ATOM   986  O  O    . ASP   A 1 152 ? -18.68719 -41.42226 13.04524  1.000 31.11382 ? 157  ASP   A O    1 
ATOM   987  C  CB   . ASP   A 1 152 ? -21.57120 -41.50218 13.68320  1.000 31.04694 ? 157  ASP   A CB   1 
ATOM   988  C  CG   . ASP   A 1 152 ? -21.56423 -41.99902 15.11126  1.000 33.67055 ? 157  ASP   A CG   1 
ATOM   989  O  OD1  . ASP   A 1 152 ? -20.50124 -41.92495 15.76727  1.000 35.77614 ? 157  ASP   A OD1  1 
ATOM   990  O  OD2  . ASP   A 1 152 ? -22.62824 -42.44096 15.58529  1.000 38.13473 ? 157  ASP   A OD2  1 
ATOM   991  N  N    . VAL   A 1 153 ? -18.59421 -39.79708 14.60206  1.000 25.66533 ? 158  VAL   A N    1 
ATOM   992  C  CA   . VAL   A 1 153 ? -17.16222 -39.98207 14.82711  1.000 28.26940 ? 158  VAL   A CA   1 
ATOM   993  C  C    . VAL   A 1 153 ? -16.85323 -41.42502 15.20427  1.000 35.61651 ? 158  VAL   A C    1 
ATOM   994  O  O    . VAL   A 1 153 ? -15.83922 -41.99308 14.77735  1.000 31.61041 ? 158  VAL   A O    1 
ATOM   995  C  CB   . VAL   A 1 153 ? -16.66123 -39.01695 15.91901  1.000 31.49513 ? 158  VAL   A CB   1 
ATOM   996  C  CG1  . VAL   A 1 153 ? -15.25324 -39.42490 16.37508  1.000 30.91621 ? 158  VAL   A CG1  1 
ATOM   997  C  CG2  . VAL   A 1 153 ? -16.67722 -37.56400 15.43185  1.000 27.50662 ? 158  VAL   A CG2  1 
ATOM   998  N  N    . LYS   A 1 154 ? -17.70724 -42.03493 16.02733  1.000 35.74485 ? 159  LYS   A N    1 
ATOM   999  C  CA   . LYS   A 1 154 ? -17.36626 -43.32787 16.61047  1.000 34.29304 ? 159  LYS   A CA   1 
ATOM   1000 C  C    . LYS   A 1 154 ? -17.67325 -44.48497 15.67160  1.000 38.13094 ? 159  LYS   A C    1 
ATOM   1001 O  O    . LYS   A 1 154 ? -16.98625 -45.50997 15.71972  1.000 42.73380 ? 159  LYS   A O    1 
ATOM   1002 C  CB   . LYS   A 1 154 ? -18.08528 -43.49372 17.95048  1.000 32.84663 ? 159  LYS   A CB   1 
ATOM   1003 C  CG   . LYS   A 1 154 ? -17.39429 -42.72760 19.07641  1.000 41.83173 ? 159  LYS   A CG   1 
ATOM   1004 C  CD   . LYS   A 1 154 ? -15.92130 -43.21259 19.19648  1.000 49.56607 ? 159  LYS   A CD   1 
ATOM   1005 C  CE   . LYS   A 1 154 ? -15.12731 -42.52747 20.32142  1.000 54.44456 ? 159  LYS   A CE   1 
ATOM   1006 N  NZ   . LYS   A 1 154 ? -14.67330 -41.12850 19.99027  1.000 50.08191 ? 159  LYS   A NZ   1 
ATOM   1007 N  N    . THR   A 1 155 ? -18.66823 -44.34406 14.80356  1.000 33.19797 ? 160  THR   A N    1 
ATOM   1008 C  CA   . THR   A 1 155 ? -18.96822 -45.38517 13.83567  1.000 33.06031 ? 160  THR   A CA   1 
ATOM   1009 C  C    . THR   A 1 155 ? -18.34820 -45.12932 12.46966  1.000 35.14564 ? 160  THR   A C    1 
ATOM   1010 O  O    . THR   A 1 155 ? -18.20819 -46.07541 11.68776  1.000 36.19186 ? 160  THR   A O    1 
ATOM   1011 C  CB   . THR   A 1 155 ? -20.48722 -45.53918 13.67067  1.000 37.99438 ? 160  THR   A CB   1 
ATOM   1012 O  OG1  . THR   A 1 155 ? -21.01420 -44.40126 12.97153  1.000 37.59987 ? 160  THR   A OG1  1 
ATOM   1013 C  CG2  . THR   A 1 155 ? -21.16624 -45.64803 15.03267  1.000 35.12899 ? 160  THR   A CG2  1 
ATOM   1014 N  N    . GLY   A 1 156 ? -17.96919 -43.88636 12.17353  1.000 37.31918 ? 161  GLY   A N    1 
ATOM   1015 C  CA   . GLY   A 1 156 ? -17.51317 -43.54150 10.84449  1.000 30.88775 ? 161  GLY   A CA   1 
ATOM   1016 C  C    . GLY   A 1 156 ? -18.60915 -43.48961 9.80547   1.000 33.47625 ? 161  GLY   A C    1 
ATOM   1017 O  O    . GLY   A 1 156 ? -18.31413 -43.38875 8.60946   1.000 36.28128 ? 161  GLY   A O    1 
ATOM   1018 N  N    . LYS   A 1 157 ? -19.86616 -43.54456 10.22846  1.000 33.72194 ? 162  LYS   A N    1 
ATOM   1019 C  CA   . LYS   A 1 157 ? -21.00314 -43.60666 9.32845   1.000 42.73087 ? 162  LYS   A CA   1 
ATOM   1020 C  C    . LYS   A 1 157 ? -21.56413 -42.21268 9.11228   1.000 33.57035 ? 162  LYS   A C    1 
ATOM   1021 O  O    . LYS   A 1 157 ? -21.53514 -41.36558 10.01019  1.000 30.26270 ? 162  LYS   A O    1 
ATOM   1022 C  CB   . LYS   A 1 157 ? -22.10015 -44.52859 9.88353   1.000 44.44639 ? 162  LYS   A CB   1 
ATOM   1023 C  CG   . LYS   A 1 157 ? -21.66316 -45.98057 10.08070  1.000 50.11668 ? 162  LYS   A CG   1 
ATOM   1024 C  CD   . LYS   A 1 157 ? -21.31114 -46.63072 8.75078   1.000 55.60207 ? 162  LYS   A CD   1 
ATOM   1025 C  CE   . LYS   A 1 157 ? -20.94115 -48.10870 8.91694   1.000 70.48853 ? 162  LYS   A CE   1 
ATOM   1026 N  NZ   . LYS   A 1 157 ? -20.57313 -48.72685 7.60202   1.000 75.78973 ? 162  LYS   A NZ   1 
ATOM   1027 N  N    . CYS   A 1 158 ? -22.08311 -41.98281 7.90825   1.000 31.10073 ? 163  CYS   A N    1 
ATOM   1028 C  CA   . CYS   A 1 158 ? -22.72910 -40.71484 7.60210   1.000 24.89761 ? 163  CYS   A CA   1 
ATOM   1029 C  C    . CYS   A 1 158 ? -24.11211 -40.69877 8.24008   1.000 30.32324 ? 163  CYS   A C    1 
ATOM   1030 O  O    . CYS   A 1 158 ? -24.92811 -41.58479 7.97716   1.000 33.29803 ? 163  CYS   A O    1 
ATOM   1031 C  CB   . CYS   A 1 158 ? -22.82508 -40.50601 6.09107   1.000 25.42908 ? 163  CYS   A CB   1 
ATOM   1032 S  SG   . CYS   A 1 158 ? -23.55007 -38.88605 5.65788   1.000 30.69655 ? 163  CYS   A SG   1 
ATOM   1033 N  N    . LEU   A 1 159 ? -24.37112 -39.71267 9.09296   1.000 28.72372 ? 164  LEU   A N    1 
ATOM   1034 C  CA   . LEU   A 1 159 ? -25.67313 -39.63559 9.74493   1.000 28.25471 ? 164  LEU   A CA   1 
ATOM   1035 C  C    . LEU   A 1 159 ? -26.68512 -38.86068 8.91283   1.000 34.87682 ? 164  LEU   A C    1 
ATOM   1036 O  O    . LEU   A 1 159 ? -27.85512 -39.25069 8.85186   1.000 30.53972 ? 164  LEU   A O    1 
ATOM   1037 C  CB   . LEU   A 1 159 ? -25.54115 -38.99044 11.12586  1.000 28.98238 ? 164  LEU   A CB   1 
ATOM   1038 C  CG   . LEU   A 1 159 ? -24.80417 -39.79333 12.20196  1.000 32.33330 ? 164  LEU   A CG   1 
ATOM   1039 C  CD1  . LEU   A 1 159 ? -24.52819 -38.93219 13.42587  1.000 31.31625 ? 164  LEU   A CD1  1 
ATOM   1040 C  CD2  . LEU   A 1 159 ? -25.59418 -41.04228 12.57809  1.000 34.14956 ? 164  LEU   A CD2  1 
ATOM   1041 N  N    . LYS   A 1 160 ? -26.25610 -37.76976 8.27372   1.000 27.58815 ? 165  LYS   A N    1 
ATOM   1042 C  CA   . LYS   A 1 160 ? -27.13509 -36.91884 7.48561   1.000 31.03481 ? 165  LYS   A CA   1 
ATOM   1043 C  C    . LYS   A 1 160 ? -26.38707 -36.37598 6.27756   1.000 33.44913 ? 165  LYS   A C    1 
ATOM   1044 O  O    . LYS   A 1 160 ? -25.19707 -36.05397 6.37155   1.000 30.36318 ? 165  LYS   A O    1 
ATOM   1045 C  CB   . LYS   A 1 160 ? -27.67610 -35.74175 8.31147   1.000 33.95493 ? 165  LYS   A CB   1 
ATOM   1046 C  CG   . LYS   A 1 160 ? -28.68811 -36.11862 9.37150   1.000 46.86630 ? 165  LYS   A CG   1 
ATOM   1047 C  CD   . LYS   A 1 160 ? -29.17812 -34.88254 10.11935  1.000 47.98730 ? 165  LYS   A CD   1 
ATOM   1048 C  CE   . LYS   A 1 160 ? -30.40514 -35.21845 10.94037  1.000 45.41076 ? 165  LYS   A CE   1 
ATOM   1049 N  NZ   . LYS   A 1 160 ? -31.45612 -35.83054 10.05842  1.000 53.66902 ? 165  LYS   A NZ   1 
ATOM   1050 N  N    . THR   A 1 161 ? -27.09105 -36.27610 5.15354   1.000 27.09964 ? 166  THR   A N    1 
ATOM   1051 C  CA   . THR   A 1 161 ? -26.60303 -35.58423 3.95747   1.000 29.24525 ? 166  THR   A CA   1 
ATOM   1052 C  C    . THR   A 1 161 ? -27.51202 -34.38626 3.69932   1.000 32.06621 ? 166  THR   A C    1 
ATOM   1053 O  O    . THR   A 1 161 ? -28.68801 -34.55729 3.36432   1.000 28.80162 ? 166  THR   A O    1 
ATOM   1054 C  CB   . THR   A 1 161 ? -26.58201 -36.50637 2.73657   1.000 31.85063 ? 166  THR   A CB   1 
ATOM   1055 O  OG1  . THR   A 1 161 ? -25.70102 -37.60934 2.97271   1.000 33.30964 ? 166  THR   A OG1  1 
ATOM   1056 C  CG2  . THR   A 1 161 ? -26.10399 -35.74550 1.51350   1.000 28.78800 ? 166  THR   A CG2  1 
ATOM   1057 N  N    . LEU   A 1 162 ? -26.96501 -33.17524 3.82320   1.000 26.98477 ? 167  LEU   A N    1 
ATOM   1058 C  CA   . LEU   A 1 162 ? -27.78101 -31.98427 3.58405   1.000 27.07001 ? 167  LEU   A CA   1 
ATOM   1059 C  C    . LEU   A 1 162 ? -27.66898 -31.54643 2.12701   1.000 26.07664 ? 167  LEU   A C    1 
ATOM   1060 O  O    . LEU   A 1 162 ? -26.55997 -31.41749 1.61401   1.000 23.94164 ? 167  LEU   A O    1 
ATOM   1061 C  CB   . LEU   A 1 162 ? -27.35002 -30.84417 4.49094   1.000 25.15265 ? 167  LEU   A CB   1 
ATOM   1062 C  CG   . LEU   A 1 162 ? -27.09604 -31.19301 5.96498   1.000 23.68900 ? 167  LEU   A CG   1 
ATOM   1063 C  CD1  . LEU   A 1 162 ? -26.76105 -29.92692 6.74484   1.000 23.91121 ? 167  LEU   A CD1  1 
ATOM   1064 C  CD2  . LEU   A 1 162 ? -28.31305 -31.85994 6.55003   1.000 26.08805 ? 167  LEU   A CD2  1 
ATOM   1065 N  N    . PRO   A 1 163 ? -28.77397 -31.30750 1.44296   1.000 28.39502 ? 168  PRO   A N    1 
ATOM   1066 C  CA   . PRO   A 1 163 ? -28.69895 -30.72565 0.08590   1.000 28.80727 ? 168  PRO   A CA   1 
ATOM   1067 C  C    . PRO   A 1 163 ? -28.42894 -29.23064 0.20374   1.000 25.75413 ? 168  PRO   A C    1 
ATOM   1068 O  O    . PRO   A 1 163 ? -29.25993 -28.35967 -0.10637  1.000 21.84181 ? 168  PRO   A O    1 
ATOM   1069 C  CB   . PRO   A 1 163 ? -30.08094 -31.05071 -0.48409  1.000 31.14015 ? 168  PRO   A CB   1 
ATOM   1070 C  CG   . PRO   A 1 163 ? -30.99096 -30.91957 0.73689   1.000 34.08091 ? 168  PRO   A CG   1 
ATOM   1071 C  CD   . PRO   A 1 163 ? -30.16498 -31.45944 1.90696   1.000 28.04491 ? 168  PRO   A CD   1 
ATOM   1072 N  N    . ALA   A 1 164 ? -27.22395 -28.92259 0.68373   1.000 24.75230 ? 169  ALA   A N    1 
ATOM   1073 C  CA   . ALA   A 1 164 ? -27.00295 -27.63552 1.32959   1.000 24.71004 ? 169  ALA   A CA   1 
ATOM   1074 C  C    . ALA   A 1 164 ? -27.05293 -26.48763 0.33446   1.000 22.61131 ? 169  ALA   A C    1 
ATOM   1075 O  O    . ALA   A 1 164 ? -27.56194 -25.40259 0.65033   1.000 21.22445 ? 169  ALA   A O    1 
ATOM   1076 C  CB   . ALA   A 1 164 ? -25.65897 -27.64044 2.05361   1.000 18.23794 ? 169  ALA   A CB   1 
ATOM   1077 N  N    . HIS   A 1 165 ? -26.51692 -26.70076 -0.86051  1.000 22.59627 ? 170  HIS   A N    1 
ATOM   1078 C  CA   . HIS   A 1 165 ? -26.18890 -25.59786 -1.74763  1.000 23.90682 ? 170  HIS   A CA   1 
ATOM   1079 C  C    . HIS   A 1 165 ? -26.33488 -26.06502 -3.17958  1.000 19.73421 ? 170  HIS   A C    1 
ATOM   1080 O  O    . HIS   A 1 165 ? -26.47388 -27.26105 -3.45245  1.000 21.25513 ? 170  HIS   A O    1 
ATOM   1081 C  CB   . HIS   A 1 165 ? -24.76390 -25.09384 -1.49566  1.000 19.30300 ? 170  HIS   A CB   1 
ATOM   1082 C  CG   . HIS   A 1 165 ? -24.60492 -24.39370 -0.18473  1.000 16.66666 ? 170  HIS   A CG   1 
ATOM   1083 N  ND1  . HIS   A 1 165 ? -24.99092 -23.08267 0.00912   1.000 18.22214 ? 170  HIS   A ND1  1 
ATOM   1084 C  CD2  . HIS   A 1 165 ? -24.11894 -24.82657 1.00232   1.000 18.79896 ? 170  HIS   A CD2  1 
ATOM   1085 C  CE1  . HIS   A 1 165 ? -24.72894 -22.73354 1.25808   1.000 21.22293 ? 170  HIS   A CE1  1 
ATOM   1086 N  NE2  . HIS   A 1 165 ? -24.19595 -23.77347 1.88121   1.000 18.98646 ? 170  HIS   A NE2  1 
ATOM   1087 N  N    . SER   A 1 166 ? -26.26686 -25.10512 -4.10068  1.000 21.15780 ? 171  SER   A N    1 
ATOM   1088 C  CA   . SER   A 1 166 ? -26.35584 -25.41528 -5.52165  1.000 21.70891 ? 171  SER   A CA   1 
ATOM   1089 C  C    . SER   A 1 166 ? -25.02682 -25.20836 -6.24365  1.000 25.13731 ? 171  SER   A C    1 
ATOM   1090 O  O    . SER   A 1 166 ? -24.99981 -25.21650 -7.47865  1.000 19.68570 ? 171  SER   A O    1 
ATOM   1091 C  CB   . SER   A 1 166 ? -27.48082 -24.60135 -6.18676  1.000 22.11749 ? 171  SER   A CB   1 
ATOM   1092 O  OG   . SER   A 1 166 ? -27.27482 -23.19933 -6.06091  1.000 23.61294 ? 171  SER   A OG   1 
ATOM   1093 N  N    . ASP   A 1 167 ? -23.92984 -25.06828 -5.49665  1.000 20.92749 ? 172  ASP   A N    1 
ATOM   1094 C  CA   . ASP   A 1 167 ? -22.57083 -24.98235 -6.02464  1.000 22.28700 ? 172  ASP   A CA   1 
ATOM   1095 C  C    . ASP   A 1 167 ? -21.64485 -25.54323 -4.95956  1.000 21.39396 ? 172  ASP   A C    1 
ATOM   1096 O  O    . ASP   A 1 167 ? -22.07987 -25.82611 -3.83653  1.000 20.38587 ? 172  ASP   A O    1 
ATOM   1097 C  CB   . ASP   A 1 167 ? -22.16782 -23.53839 -6.35779  1.000 21.70199 ? 172  ASP   A CB   1 
ATOM   1098 C  CG   . ASP   A 1 167 ? -22.77079 -23.02853 -7.66785  1.000 29.03471 ? 172  ASP   A CG   1 
ATOM   1099 O  OD1  . ASP   A 1 167 ? -22.52278 -23.63465 -8.72878  1.000 24.18367 ? 172  ASP   A OD1  1 
ATOM   1100 O  OD2  . ASP   A 1 167 ? -23.49779 -22.01252 -7.62198  1.000 28.34391 ? 172  ASP   A OD2  1 
ATOM   1101 N  N    . PRO   A 1 168 ? -20.35484 -25.67827 -5.26052  1.000 23.46703 ? 173  PRO   A N    1 
ATOM   1102 C  CA   . PRO   A 1 168 ? -19.42986 -26.24917 -4.27245  1.000 19.58551 ? 173  PRO   A CA   1 
ATOM   1103 C  C    . PRO   A 1 168 ? -19.45188 -25.52802 -2.91953  1.000 21.87710 ? 173  PRO   A C    1 
ATOM   1104 O  O    . PRO   A 1 168 ? -19.59688 -24.30301 -2.82366  1.000 20.92199 ? 173  PRO   A O    1 
ATOM   1105 C  CB   . PRO   A 1 168 ? -18.06685 -26.12825 -4.96644  1.000 19.14555 ? 173  PRO   A CB   1 
ATOM   1106 C  CG   . PRO   A 1 168 ? -18.41483 -26.31641 -6.43742  1.000 20.11133 ? 173  PRO   A CG   1 
ATOM   1107 C  CD   . PRO   A 1 168 ? -19.72482 -25.54342 -6.59153  1.000 22.72315 ? 173  PRO   A CD   1 
ATOM   1108 N  N    . VAL   A 1 169 ? -19.28890 -26.31890 -1.87044  1.000 20.86079 ? 174  VAL   A N    1 
ATOM   1109 C  CA   . VAL   A 1 169 ? -19.28892 -25.83475 -0.49349  1.000 19.10146 ? 174  VAL   A CA   1 
ATOM   1110 C  C    . VAL   A 1 169 ? -17.85292 -25.54271 -0.08150  1.000 19.41877 ? 174  VAL   A C    1 
ATOM   1111 O  O    . VAL   A 1 169 ? -16.97793 -26.41473 -0.20139  1.000 20.13920 ? 174  VAL   A O    1 
ATOM   1112 C  CB   . VAL   A 1 169 ? -19.91594 -26.88364 0.43962   1.000 19.69178 ? 174  VAL   A CB   1 
ATOM   1113 C  CG1  . VAL   A 1 169 ? -19.78996 -26.43848 1.89057   1.000 20.45973 ? 174  VAL   A CG1  1 
ATOM   1114 C  CG2  . VAL   A 1 169 ? -21.39393 -27.14768 0.03662   1.000 18.85238 ? 174  VAL   A CG2  1 
ATOM   1115 N  N    . SER   A 1 170 ? -17.61193 -24.33465 0.43937   1.000 18.32516 ? 175  SER   A N    1 
ATOM   1116 C  CA   . SER   A 1 170 ? -16.25893 -23.87862 0.74534   1.000 16.47955 ? 175  SER   A CA   1 
ATOM   1117 C  C    . SER   A 1 170 ? -15.87396 -23.97246 2.22236   1.000 17.74370 ? 175  SER   A C    1 
ATOM   1118 O  O    . SER   A 1 170 ? -14.67796 -24.03543 2.52939   1.000 19.05730 ? 175  SER   A O    1 
ATOM   1119 C  CB   . SER   A 1 170 ? -16.08292 -22.43368 0.25719   1.000 22.04582 ? 175  SER   A CB   1 
ATOM   1120 O  OG   . SER   A 1 170 ? -17.07292 -21.58461 0.81208   1.000 18.50785 ? 175  SER   A OG   1 
ATOM   1121 N  N    . ALA   A 1 171 ? -16.82997 -23.98836 3.14335   1.000 18.23845 ? 176  ALA   A N    1 
ATOM   1122 C  CA   . ALA   A 1 171 ? -16.48699 -24.03120 4.56136   1.000 15.98474 ? 176  ALA   A CA   1 
ATOM   1123 C  C    . ALA   A 1 171 ? -17.68301 -24.57411 5.33740   1.000 21.22616 ? 176  ALA   A C    1 
ATOM   1124 O  O    . ALA   A 1 171 ? -18.82900 -24.43515 4.90836   1.000 18.39601 ? 176  ALA   A O    1 
ATOM   1125 C  CB   . ALA   A 1 171 ? -16.07900 -22.63615 5.07621   1.000 16.21550 ? 176  ALA   A CB   1 
ATOM   1126 N  N    . VAL   A 1 172 ? -17.40403 -25.21799 6.47447   1.000 20.04134 ? 177  VAL   A N    1 
ATOM   1127 C  CA   . VAL   A 1 172 ? -18.44004 -25.69488 7.39051   1.000 17.05485 ? 177  VAL   A CA   1 
ATOM   1128 C  C    . VAL   A 1 172 ? -17.89807 -25.54173 8.80350   1.000 21.04077 ? 177  VAL   A C    1 
ATOM   1129 O  O    . VAL   A 1 172 ? -16.70107 -25.72671 9.03554   1.000 20.97472 ? 177  VAL   A O    1 
ATOM   1130 C  CB   . VAL   A 1 172 ? -18.83405 -27.16991 7.13967   1.000 20.96704 ? 177  VAL   A CB   1 
ATOM   1131 C  CG1  . VAL   A 1 172 ? -19.60802 -27.34005 5.81467   1.000 23.69605 ? 177  VAL   A CG1  1 
ATOM   1132 C  CG2  . VAL   A 1 172 ? -17.59405 -28.05891 7.16878   1.000 22.32722 ? 177  VAL   A CG2  1 
ATOM   1133 N  N    . HIS   A 1 173 ? -18.76608 -25.19262 9.75145   1.000 21.55931 ? 178  HIS   A N    1 
ATOM   1134 C  CA   . HIS   A 1 173 ? -18.30410 -24.89447 11.10542  1.000 21.84883 ? 178  HIS   A CA   1 
ATOM   1135 C  C    . HIS   A 1 173 ? -19.47612 -25.04536 12.06842  1.000 25.31115 ? 178  HIS   A C    1 
ATOM   1136 O  O    . HIS   A 1 173 ? -20.58911 -24.60839 11.75235  1.000 22.20478 ? 178  HIS   A O    1 
ATOM   1137 C  CB   . HIS   A 1 173 ? -17.73110 -23.47247 11.17627  1.000 20.19159 ? 178  HIS   A CB   1 
ATOM   1138 C  CG   . HIS   A 1 173 ? -17.07412 -23.13232 12.48225  1.000 27.66379 ? 178  HIS   A CG   1 
ATOM   1139 N  ND1  . HIS   A 1 173 ? -17.33912 -21.96425 13.17011  1.000 23.66709 ? 178  HIS   A ND1  1 
ATOM   1140 C  CD2  . HIS   A 1 173 ? -16.15513 -23.79925 13.22034  1.000 27.14911 ? 178  HIS   A CD2  1 
ATOM   1141 C  CE1  . HIS   A 1 173 ? -16.60814 -21.92513 14.27012  1.000 27.38784 ? 178  HIS   A CE1  1 
ATOM   1142 N  NE2  . HIS   A 1 173 ? -15.88814 -23.03213 14.32826  1.000 26.04058 ? 178  HIS   A NE2  1 
ATOM   1143 N  N    . PHE   A 1 174 ? -19.22814 -25.70124 13.21450  1.000 20.82697 ? 179  PHE   A N    1 
ATOM   1144 C  CA   . PHE   A 1 174 ? -20.19515 -25.75411 14.31149  1.000 24.25000 ? 179  PHE   A CA   1 
ATOM   1145 C  C    . PHE   A 1 174 ? -20.08416 -24.50902 15.18135  1.000 26.70794 ? 179  PHE   A C    1 
ATOM   1146 O  O    . PHE   A 1 174 ? -19.00016 -23.94200 15.34231  1.000 22.67192 ? 179  PHE   A O    1 
ATOM   1147 C  CB   . PHE   A 1 174 ? -19.95817 -26.96501 15.21863  1.000 23.27523 ? 179  PHE   A CB   1 
ATOM   1148 C  CG   . PHE   A 1 174 ? -20.39317 -28.27907 14.64276  1.000 24.75892 ? 179  PHE   A CG   1 
ATOM   1149 C  CD1  . PHE   A 1 174 ? -21.72917 -28.67106 14.70679  1.000 23.19950 ? 179  PHE   A CD1  1 
ATOM   1150 C  CD2  . PHE   A 1 174 ? -19.45916 -29.14714 14.07787  1.000 20.60843 ? 179  PHE   A CD2  1 
ATOM   1151 C  CE1  . PHE   A 1 174 ? -22.13517 -29.90511 14.21092  1.000 23.57386 ? 179  PHE   A CE1  1 
ATOM   1152 C  CE2  . PHE   A 1 174 ? -19.85416 -30.38019 13.56400  1.000 23.94435 ? 179  PHE   A CE2  1 
ATOM   1153 C  CZ   . PHE   A 1 174 ? -21.19716 -30.76718 13.63303  1.000 23.39579 ? 179  PHE   A CZ   1 
ATOM   1154 N  N    . ASN   A 1 175 ? -21.21017 -24.11094 15.78129  1.000 25.13926 ? 180  ASN   A N    1 
ATOM   1155 C  CA   . ASN   A 1 175 ? -21.18318 -23.01684 16.74117  1.000 24.37918 ? 180  ASN   A CA   1 
ATOM   1156 C  C    . ASN   A 1 175 ? -20.72621 -23.54969 18.09924  1.000 28.28715 ? 180  ASN   A C    1 
ATOM   1157 O  O    . ASN   A 1 175 ? -20.49521 -24.74567 18.27537  1.000 22.09998 ? 180  ASN   A O    1 
ATOM   1158 C  CB   . ASN   A 1 175 ? -22.55018 -22.33882 16.83807  1.000 25.72426 ? 180  ASN   A CB   1 
ATOM   1159 C  CG   . ASN   A 1 175 ? -23.59520 -23.20674 17.52215  1.000 23.51883 ? 180  ASN   A CG   1 
ATOM   1160 O  OD1  . ASN   A 1 175 ? -23.51420 -24.43774 17.51529  1.000 25.71918 ? 180  ASN   A OD1  1 
ATOM   1161 N  ND2  . ASN   A 1 175 ? -24.59920 -22.56068 18.10206  1.000 26.32690 ? 180  ASN   A ND2  1 
ATOM   1162 N  N    . ARG   A 1 176 ? -20.63522 -22.65658 19.08914  1.000 29.76500 ? 181  ARG   A N    1 
ATOM   1163 C  CA   . ARG   A 1 176 ? -19.91924 -22.99945 20.31619  1.000 34.58412 ? 181  ARG   A CA   1 
ATOM   1164 C  C    . ARG   A 1 176 ? -20.61026 -24.10136 21.12030  1.000 33.92985 ? 181  ARG   A C    1 
ATOM   1165 O  O    . ARG   A 1 176 ? -19.93527 -24.83228 21.85139  1.000 30.96774 ? 181  ARG   A O    1 
ATOM   1166 C  CB   . ARG   A 1 176 ? -19.71525 -21.75035 21.18005  1.000 32.26572 ? 181  ARG   A CB   1 
ATOM   1167 C  CG   . ARG   A 1 176 ? -20.98926 -21.24128 21.80798  1.000 44.61566 ? 181  ARG   A CG   1 
ATOM   1168 C  CD   . ARG   A 1 176 ? -20.83726 -19.83622 22.39682  1.000 51.87343 ? 181  ARG   A CD   1 
ATOM   1169 N  NE   . ARG   A 1 176 ? -20.00628 -19.79009 23.59383  1.000 62.82452 ? 181  ARG   A NE   1 
ATOM   1170 C  CZ   . ARG   A 1 176 ? -19.89729 -18.72900 24.38772  1.000 67.97230 ? 181  ARG   A CZ   1 
ATOM   1171 N  NH1  . ARG   A 1 176 ? -20.60028 -17.62502 24.17158  1.000 59.71975 ? 181  ARG   A NH1  1 
ATOM   1172 N  NH2  . ARG   A 1 176 ? -19.06531 -18.77689 25.42574  1.000 75.95853 ? 181  ARG   A NH2  1 
ATOM   1173 N  N    . ASP   A 1 177 ? -21.93526 -24.26537 21.00030  1.000 28.78696 ? 182  ASP   A N    1 
ATOM   1174 C  CA   . ASP   A 1 177 ? -22.61227 -25.35229 21.70440  1.000 32.18062 ? 182  ASP   A CA   1 
ATOM   1175 C  C    . ASP   A 1 177 ? -23.00226 -26.50039 20.78553  1.000 31.53270 ? 182  ASP   A C    1 
ATOM   1176 O  O    . ASP   A 1 177 ? -23.70227 -27.42233 21.22362  1.000 29.02190 ? 182  ASP   A O    1 
ATOM   1177 C  CB   . ASP   A 1 177 ? -23.83528 -24.83420 22.47933  1.000 30.86871 ? 182  ASP   A CB   1 
ATOM   1178 C  CG   . ASP   A 1 177 ? -24.98726 -24.40329 21.58326  1.000 36.14132 ? 182  ASP   A CG   1 
ATOM   1179 O  OD1  . ASP   A 1 177 ? -24.98125 -24.66042 20.36129  1.000 33.50339 ? 182  ASP   A OD1  1 
ATOM   1180 O  OD2  . ASP   A 1 177 ? -25.93127 -23.79223 22.12618  1.000 34.93931 ? 182  ASP   A OD2  1 
ATOM   1181 N  N    . GLY   A 1 178 ? -22.56724 -26.46853 19.52653  1.000 29.55656 ? 183  GLY   A N    1 
ATOM   1182 C  CA   . GLY   A 1 178 ? -22.78823 -27.56563 18.61465  1.000 23.47958 ? 183  GLY   A CA   1 
ATOM   1183 C  C    . GLY   A 1 178 ? -24.20622 -27.70468 18.10564  1.000 21.00523 ? 183  GLY   A C    1 
ATOM   1184 O  O    . GLY   A 1 178 ? -24.48621 -28.66276 17.38274  1.000 19.99137 ? 183  GLY   A O    1 
ATOM   1185 N  N    . SER   A 1 179 ? -25.10922 -26.78264 18.45052  1.000 25.10879 ? 184  SER   A N    1 
ATOM   1186 C  CA   . SER   A 1 179 ? -26.48622 -26.89368 17.98451  1.000 28.63537 ? 184  SER   A CA   1 
ATOM   1187 C  C    . SER   A 1 179 ? -26.66819 -26.39984 16.55446  1.000 26.73085 ? 184  SER   A C    1 
ATOM   1188 O  O    . SER   A 1 179 ? -27.66018 -26.77191 15.91648  1.000 24.20316 ? 184  SER   A O    1 
ATOM   1189 C  CB   . SER   A 1 179 ? -27.43623 -26.12858 18.91641  1.000 25.40726 ? 184  SER   A CB   1 
ATOM   1190 O  OG   . SER   A 1 179 ? -27.04523 -24.76956 19.03527  1.000 31.12005 ? 184  SER   A OG   1 
ATOM   1191 N  N    . LEU   A 1 180 ? -25.74318 -25.58190 16.03938  1.000 22.97051 ? 185  LEU   A N    1 
ATOM   1192 C  CA   . LEU   A 1 180 ? -25.83816 -25.01005 14.69932  1.000 24.91670 ? 185  LEU   A CA   1 
ATOM   1193 C  C    . LEU   A 1 180 ? -24.59515 -25.33114 13.87937  1.000 24.42500 ? 185  LEU   A C    1 
ATOM   1194 O  O    . LEU   A 1 180 ? -23.48815 -25.42309 14.41540  1.000 23.78453 ? 185  LEU   A O    1 
ATOM   1195 C  CB   . LEU   A 1 180 ? -26.00115 -23.48504 14.75114  1.000 23.36810 ? 185  LEU   A CB   1 
ATOM   1196 C  CG   . LEU   A 1 180 ? -27.24116 -22.96096 15.47207  1.000 22.43123 ? 185  LEU   A CG   1 
ATOM   1197 C  CD1  . LEU   A 1 180 ? -27.18716 -21.43794 15.60390  1.000 24.01939 ? 185  LEU   A CD1  1 
ATOM   1198 C  CD2  . LEU   A 1 180 ? -28.47115 -23.37904 14.70309  1.000 25.59914 ? 185  LEU   A CD2  1 
ATOM   1199 N  N    . ILE   A 1 181 ? -24.79713 -25.48929 12.57138  1.000 24.21752 ? 186  ILE   A N    1 
ATOM   1200 C  CA   . ILE   A 1 181 ? -23.73511 -25.57040 11.57341  1.000 22.87696 ? 186  ILE   A CA   1 
ATOM   1201 C  C    . ILE   A 1 181 ? -23.92209 -24.41351 10.60628  1.000 23.20452 ? 186  ILE   A C    1 
ATOM   1202 O  O    . ILE   A 1 181 ? -25.04908 -24.13655 10.17623  1.000 21.96406 ? 186  ILE   A O    1 
ATOM   1203 C  CB   . ILE   A 1 181 ? -23.78410 -26.90349 10.79856  1.000 22.51805 ? 186  ILE   A CB   1 
ATOM   1204 C  CG1  . ILE   A 1 181 ? -23.49312 -28.08939 11.71469  1.000 19.32518 ? 186  ILE   A CG1  1 
ATOM   1205 C  CG2  . ILE   A 1 181 ? -22.83008 -26.86162 9.58257   1.000 21.11072 ? 186  ILE   A CG2  1 
ATOM   1206 C  CD1  . ILE   A 1 181 ? -23.88112 -29.41645 11.08483  1.000 21.93243 ? 186  ILE   A CD1  1 
ATOM   1207 N  N    . VAL   A 1 182 ? -22.83308 -23.73955 10.25622  1.000 20.92009 ? 187  VAL   A N    1 
ATOM   1208 C  CA   . VAL   A 1 182 ? -22.86706 -22.73267 9.20111   1.000 20.96619 ? 187  VAL   A CA   1 
ATOM   1209 C  C    . VAL   A 1 182 ? -22.08204 -23.26480 8.00718   1.000 22.07855 ? 187  VAL   A C    1 
ATOM   1210 O  O    . VAL   A 1 182 ? -21.07305 -23.95979 8.17328   1.000 19.48530 ? 187  VAL   A O    1 
ATOM   1211 C  CB   . VAL   A 1 182 ? -22.33206 -21.36962 9.67297   1.000 24.15208 ? 187  VAL   A CB   1 
ATOM   1212 C  CG1  . VAL   A 1 182 ? -20.85307 -21.45258 10.02900  1.000 22.17158 ? 187  VAL   A CG1  1 
ATOM   1213 C  CG2  . VAL   A 1 182 ? -22.60504 -20.30273 8.60585   1.000 19.90876 ? 187  VAL   A CG2  1 
ATOM   1214 N  N    . SER   A 1 183 ? -22.58102 -22.98193 6.79914   1.000 25.48646 ? 188  SER   A N    1 
ATOM   1215 C  CA   . SER   A 1 183 ? -21.91601 -23.37707 5.56620   1.000 20.68042 ? 188  SER   A CA   1 
ATOM   1216 C  C    . SER   A 1 183 ? -21.87999 -22.20418 4.59607   1.000 23.01627 ? 188  SER   A C    1 
ATOM   1217 O  O    . SER   A 1 183 ? -22.71298 -21.29717 4.65996   1.000 20.71695 ? 188  SER   A O    1 
ATOM   1218 C  CB   . SER   A 1 183 ? -22.61100 -24.56714 4.89632   1.000 18.91557 ? 188  SER   A CB   1 
ATOM   1219 O  OG   . SER   A 1 183 ? -23.95499 -24.25317 4.56626   1.000 19.86681 ? 188  SER   A OG   1 
ATOM   1220 N  N    . SER   A 1 184 ? -20.89897 -22.23328 3.69309   1.000 17.90434 ? 189  SER   A N    1 
ATOM   1221 C  CA   . SER   A 1 184 ? -20.72995 -21.19639 2.68698   1.000 19.50865 ? 189  SER   A CA   1 
ATOM   1222 C  C    . SER   A 1 184 ? -20.48693 -21.88254 1.35306   1.000 19.46663 ? 189  SER   A C    1 
ATOM   1223 O  O    . SER   A 1 184 ? -19.94494 -22.99155 1.29619   1.000 20.44976 ? 189  SER   A O    1 
ATOM   1224 C  CB   . SER   A 1 184 ? -19.54695 -20.24336 3.04089   1.000 19.57347 ? 189  SER   A CB   1 
ATOM   1225 O  OG   . SER   A 1 184 ? -18.35396 -20.98934 3.22699   1.000 19.08642 ? 189  SER   A OG   1 
ATOM   1226 N  N    . SER   A 1 185 ? -20.90391 -21.23466 0.27198   1.000 17.64720 ? 190  SER   A N    1 
ATOM   1227 C  CA   . SER   A 1 185 ? -20.84490 -21.91480 -1.01295  1.000 21.91067 ? 190  SER   A CA   1 
ATOM   1228 C  C    . SER   A 1 185 ? -20.54087 -20.92692 -2.12705  1.000 19.10861 ? 190  SER   A C    1 
ATOM   1229 O  O    . SER   A 1 185 ? -20.81287 -19.72191 -2.02319  1.000 19.43450 ? 190  SER   A O    1 
ATOM   1230 C  CB   . SER   A 1 185 ? -22.16589 -22.64683 -1.30789  1.000 19.33096 ? 190  SER   A CB   1 
ATOM   1231 O  OG   . SER   A 1 185 ? -22.23887 -23.05798 -2.66084  1.000 19.14097 ? 190  SER   A OG   1 
ATOM   1232 N  N    . TYR   A 1 186 ? -20.00986 -21.46905 -3.22398  1.000 17.67487 ? 191  TYR   A N    1 
ATOM   1233 C  CA   . TYR   A 1 186 ? -19.91884 -20.68318 -4.44707  1.000 17.98541 ? 191  TYR   A CA   1 
ATOM   1234 C  C    . TYR   A 1 186 ? -21.28183 -20.21423 -4.95114  1.000 21.17250 ? 191  TYR   A C    1 
ATOM   1235 O  O    . TYR   A 1 186 ? -21.32981 -19.35533 -5.84524  1.000 19.83014 ? 191  TYR   A O    1 
ATOM   1236 C  CB   . TYR   A 1 186 ? -19.21582 -21.49731 -5.53197  1.000 19.71659 ? 191  TYR   A CB   1 
ATOM   1237 C  CG   . TYR   A 1 186 ? -17.71282 -21.30731 -5.51596  1.000 21.35072 ? 191  TYR   A CG   1 
ATOM   1238 C  CD1  . TYR   A 1 186 ? -16.93584 -21.85420 -4.49589  1.000 19.16327 ? 191  TYR   A CD1  1 
ATOM   1239 C  CD2  . TYR   A 1 186 ? -17.07880 -20.54142 -6.49604  1.000 19.86620 ? 191  TYR   A CD2  1 
ATOM   1240 C  CE1  . TYR   A 1 186 ? -15.53584 -21.66620 -4.47389  1.000 21.41664 ? 191  TYR   A CE1  1 
ATOM   1241 C  CE2  . TYR   A 1 186 ? -15.70080 -20.33942 -6.47704  1.000 24.27634 ? 191  TYR   A CE2  1 
ATOM   1242 C  CZ   . TYR   A 1 186 ? -14.93782 -20.91331 -5.46596  1.000 21.54462 ? 191  TYR   A CZ   1 
ATOM   1243 O  OH   . TYR   A 1 186 ? -13.57582 -20.72432 -5.44896  1.000 23.59776 ? 191  TYR   A OH   1 
ATOM   1244 N  N    . ASP   A 1 187 ? -22.38484 -20.73617 -4.41110  1.000 18.94028 ? 192  ASP   A N    1 
ATOM   1245 C  CA   . ASP   A 1 187 ? -23.68683 -20.24221 -4.85118  1.000 23.55434 ? 192  ASP   A CA   1 
ATOM   1246 C  C    . ASP   A 1 187 ? -24.01783 -18.87215 -4.26833  1.000 27.22889 ? 192  ASP   A C    1 
ATOM   1247 O  O    . ASP   A 1 187 ? -25.09983 -18.34917 -4.52241  1.000 24.90676 ? 192  ASP   A O    1 
ATOM   1248 C  CB   . ASP   A 1 187 ? -24.79784 -21.26117 -4.52108  1.000 18.79323 ? 192  ASP   A CB   1 
ATOM   1249 C  CG   . ASP   A 1 187 ? -25.05686 -21.41701 -3.02607  1.000 19.95315 ? 192  ASP   A CG   1 
ATOM   1250 O  OD1  . ASP   A 1 187 ? -24.47387 -20.66592 -2.20214  1.000 19.67079 ? 192  ASP   A OD1  1 
ATOM   1251 O  OD2  . ASP   A 1 187 ? -25.85287 -22.32697 -2.68298  1.000 23.02407 ? 192  ASP   A OD2  1 
ATOM   1252 N  N    . GLY   A 1 188 ? -23.10684 -18.25907 -3.52539  1.000 23.38136 ? 193  GLY   A N    1 
ATOM   1253 C  CA   . GLY   A 1 188 ? -23.33285 -16.92401 -3.02854  1.000 21.37200 ? 193  GLY   A CA   1 
ATOM   1254 C  C    . GLY   A 1 188 ? -24.01787 -16.85686 -1.68256  1.000 21.08163 ? 193  GLY   A C    1 
ATOM   1255 O  O    . GLY   A 1 188 ? -24.23787 -15.75181 -1.17168  1.000 21.93852 ? 193  GLY   A O    1 
ATOM   1256 N  N    . LEU   A 1 189 ? -24.33388 -17.99380 -1.08144  1.000 17.37848 ? 194  LEU   A N    1 
ATOM   1257 C  CA   . LEU   A 1 189 ? -25.12790 -18.04466 0.13356   1.000 17.11778 ? 194  LEU   A CA   1 
ATOM   1258 C  C    . LEU   A 1 189 ? -24.30092 -18.52753 1.31162   1.000 22.96777 ? 194  LEU   A C    1 
ATOM   1259 O  O    . LEU   A 1 189 ? -23.38292 -19.33255 1.15973   1.000 19.26448 ? 194  LEU   A O    1 
ATOM   1260 C  CB   . LEU   A 1 189 ? -26.31390 -19.00467 -0.03236  1.000 21.41586 ? 194  LEU   A CB   1 
ATOM   1261 C  CG   . LEU   A 1 189 ? -27.25088 -18.75780 -1.21640  1.000 19.80056 ? 194  LEU   A CG   1 
ATOM   1262 C  CD1  . LEU   A 1 189 ? -28.38389 -19.78979 -1.17330  1.000 24.84464 ? 194  LEU   A CD1  1 
ATOM   1263 C  CD2  . LEU   A 1 189 ? -27.78388 -17.32379 -1.11856  1.000 20.79785 ? 194  LEU   A CD2  1 
ATOM   1264 N  N    A CYS   A 1 190 ? -24.61094 -17.99940 2.48956   0.731 21.06071 ? 195  CYS   A N    1 
ATOM   1265 N  N    B CYS   A 1 190 ? -24.67894 -18.05440 2.49157   0.269 21.09346 ? 195  CYS   A N    1 
ATOM   1266 C  CA   A CYS   A 1 190 ? -24.30896 -18.68426 3.73664   0.731 19.91618 ? 195  CYS   A CA   1 
ATOM   1267 C  CA   B CYS   A 1 190 ? -24.29196 -18.66226 3.75264   0.269 20.03473 ? 195  CYS   A CA   1 
ATOM   1268 C  C    A CYS   A 1 190 ? -25.60697 -19.28820 4.24369   0.731 20.84458 ? 195  CYS   A C    1 
ATOM   1269 C  C    B CYS   A 1 190 ? -25.55497 -19.21418 4.40468   0.269 20.97331 ? 195  CYS   A C    1 
ATOM   1270 O  O    A CYS   A 1 190 ? -26.67697 -18.68421 4.10660   0.731 20.07905 ? 195  CYS   A O    1 
ATOM   1271 O  O    B CYS   A 1 190 ? -26.56097 -18.50317 4.50559   0.269 20.53558 ? 195  CYS   A O    1 
ATOM   1272 C  CB   A CYS   A 1 190 ? -23.72797 -17.74615 4.79755   0.731 24.54621 ? 195  CYS   A CB   1 
ATOM   1273 C  CB   B CYS   A 1 190 ? -23.60997 -17.64016 4.65854   0.269 24.37861 ? 195  CYS   A CB   1 
ATOM   1274 S  SG   A CYS   A 1 190 ? -22.10196 -17.08920 4.41350   0.731 24.97951 ? 195  CYS   A SG   1 
ATOM   1275 S  SG   B CYS   A 1 190 ? -23.50800 -18.14898 6.35759   0.269 22.66592 ? 195  CYS   A SG   1 
ATOM   1276 N  N    . ARG   A 1 191 ? -25.51298 -20.48014 4.81682   1.000 22.51650 ? 196  ARG   A N    1 
ATOM   1277 C  CA   . ARG   A 1 191 ? -26.67899 -21.13707 5.37787   1.000 21.45479 ? 196  ARG   A CA   1 
ATOM   1278 C  C    . ARG   A 1 191 ? -26.36402 -21.67592 6.76394   1.000 25.62271 ? 196  ARG   A C    1 
ATOM   1279 O  O    . ARG   A 1 191 ? -25.22803 -22.05489 7.06300   1.000 22.90255 ? 196  ARG   A O    1 
ATOM   1280 C  CB   . ARG   A 1 191 ? -27.18198 -22.24317 4.44699   1.000 19.80986 ? 196  ARG   A CB   1 
ATOM   1281 C  CG   . ARG   A 1 191 ? -28.05396 -21.64429 3.32491   1.000 22.52091 ? 196  ARG   A CG   1 
ATOM   1282 C  CD   . ARG   A 1 191 ? -28.67095 -22.67240 2.38201   1.000 21.17639 ? 196  ARG   A CD   1 
ATOM   1283 N  NE   . ARG   A 1 191 ? -29.60194 -21.99149 1.48492   1.000 23.31655 ? 196  ARG   A NE   1 
ATOM   1284 C  CZ   . ARG   A 1 191 ? -29.97792 -22.43762 0.29497   1.000 22.88736 ? 196  ARG   A CZ   1 
ATOM   1285 N  NH1  . ARG   A 1 191 ? -29.45191 -23.53468 -0.23191  1.000 20.03778 ? 196  ARG   A NH1  1 
ATOM   1286 N  NH2  . ARG   A 1 191 ? -30.90591 -21.76869 -0.38312  1.000 19.67648 ? 196  ARG   A NH2  1 
ATOM   1287 N  N    . ILE   A 1 192 ? -27.37703 -21.66982 7.62392   1.000 22.35722 ? 197  ILE   A N    1 
ATOM   1288 C  CA   . ILE   A 1 192 ? -27.24206 -22.18467 8.97998   1.000 22.94925 ? 197  ILE   A CA   1 
ATOM   1289 C  C    . ILE   A 1 192 ? -28.19406 -23.35565 9.13610   1.000 23.18182 ? 197  ILE   A C    1 
ATOM   1290 O  O    . ILE   A 1 192 ? -29.35206 -23.29470 8.70107   1.000 27.95425 ? 197  ILE   A O    1 
ATOM   1291 C  CB   . ILE   A 1 192 ? -27.51407 -21.09656 10.03486  1.000 24.82657 ? 197  ILE   A CB   1 
ATOM   1292 C  CG1  . ILE   A 1 192 ? -26.36206 -20.09256 10.02576  1.000 27.58060 ? 197  ILE   A CG1  1 
ATOM   1293 C  CG2  . ILE   A 1 192 ? -27.68609 -21.73340 11.42892  1.000 25.36962 ? 197  ILE   A CG2  1 
ATOM   1294 C  CD1  . ILE   A 1 192 ? -26.75907 -18.73351 10.48861  1.000 33.11464 ? 197  ILE   A CD1  1 
ATOM   1295 N  N    . TRP   A 1 193 ? -27.70208 -24.41959 9.75422   1.000 21.20357 ? 198  TRP   A N    1 
ATOM   1296 C  CA   . TRP   A 1 193 ? -28.40208 -25.69258 9.81235   1.000 22.30302 ? 198  TRP   A CA   1 
ATOM   1297 C  C    . TRP   A 1 193 ? -28.54311 -26.13742 11.25840  1.000 24.63904 ? 198  TRP   A C    1 
ATOM   1298 O  O    . TRP   A 1 193 ? -27.62512 -25.95433 12.06239  1.000 22.00901 ? 198  TRP   A O    1 
ATOM   1299 C  CB   . TRP   A 1 193 ? -27.65207 -26.76067 9.02748   1.000 22.98219 ? 198  TRP   A CB   1 
ATOM   1300 C  CG   . TRP   A 1 193 ? -27.34205 -26.32182 7.65744   1.000 24.24101 ? 198  TRP   A CG   1 
ATOM   1301 C  CD1  . TRP   A 1 193 ? -26.26204 -25.57487 7.24337   1.000 23.56834 ? 198  TRP   A CD1  1 
ATOM   1302 C  CD2  . TRP   A 1 193 ? -28.12503 -26.58594 6.49445   1.000 25.54906 ? 198  TRP   A CD2  1 
ATOM   1303 N  NE1  . TRP   A 1 193 ? -26.33902 -25.36202 5.88235   1.000 22.33127 ? 198  TRP   A NE1  1 
ATOM   1304 C  CE2  . TRP   A 1 193 ? -27.47101 -25.97507 5.40040   1.000 22.70019 ? 198  TRP   A CE2  1 
ATOM   1305 C  CE3  . TRP   A 1 193 ? -29.32203 -27.28697 6.26751   1.000 22.24879 ? 198  TRP   A CE3  1 
ATOM   1306 C  CZ2  . TRP   A 1 193 ? -27.97299 -26.04221 4.10140   1.000 24.19466 ? 198  TRP   A CZ2  1 
ATOM   1307 C  CZ3  . TRP   A 1 193 ? -29.81901 -27.35111 4.97351   1.000 26.29404 ? 198  TRP   A CZ3  1 
ATOM   1308 C  CH2  . TRP   A 1 193 ? -29.14299 -26.72823 3.90645   1.000 18.62889 ? 198  TRP   A CH2  1 
ATOM   1309 N  N    . ASP   A 1 194 ? -29.69711 -26.72438 11.57344  1.000 23.84198 ? 199  ASP   A N    1 
ATOM   1310 C  CA   . ASP   A 1 194 ? -29.90814 -27.36823 12.86251  1.000 26.49048 ? 199  ASP   A CA   1 
ATOM   1311 C  C    . ASP   A 1 194 ? -29.17914 -28.70324 12.87967  1.000 22.74435 ? 199  ASP   A C    1 
ATOM   1312 O  O    . ASP   A 1 194 ? -29.51313 -29.59632 12.09476  1.000 25.50487 ? 199  ASP   A O    1 
ATOM   1313 C  CB   . ASP   A 1 194 ? -31.39914 -27.58620 13.11651  1.000 28.53391 ? 199  ASP   A CB   1 
ATOM   1314 C  CG   . ASP   A 1 194 ? -31.66317 -28.16205 14.49057  1.000 29.61949 ? 199  ASP   A CG   1 
ATOM   1315 O  OD1  . ASP   A 1 194 ? -31.73118 -27.37394 15.44448  1.000 30.47729 ? 199  ASP   A OD1  1 
ATOM   1316 O  OD2  . ASP   A 1 194 ? -31.75417 -29.39403 14.62071  1.000 29.83125 ? 199  ASP   A OD2  1 
ATOM   1317 N  N    . THR   A 1 195 ? -28.20616 -28.85514 13.78770  1.000 25.56898 ? 200  THR   A N    1 
ATOM   1318 C  CA   . THR   A 1 195 ? -27.40116 -30.07514 13.80585  1.000 23.84491 ? 200  THR   A CA   1 
ATOM   1319 C  C    . THR   A 1 195 ? -28.27617 -31.31613 13.90997  1.000 31.20917 ? 200  THR   A C    1 
ATOM   1320 O  O    . THR   A 1 195 ? -28.08316 -32.29921 13.17908  1.000 29.24493 ? 200  THR   A O    1 
ATOM   1321 C  CB   . THR   A 1 195 ? -26.41318 -30.03301 14.97086  1.000 24.90873 ? 200  THR   A CB   1 
ATOM   1322 O  OG1  . THR   A 1 195 ? -25.54517 -28.90203 14.81975  1.000 24.94497 ? 200  THR   A OG1  1 
ATOM   1323 C  CG2  . THR   A 1 195 ? -25.60419 -31.33201 15.01902  1.000 24.33249 ? 200  THR   A CG2  1 
ATOM   1324 N  N    . ALA   A 1 196 ? -29.25718 -31.28502 14.81595  1.000 26.18324 ? 201  ALA   A N    1 
ATOM   1325 C  CA   . ALA   A 1 196 ? -30.00219 -32.49298 15.14308  1.000 30.30972 ? 201  ALA   A CA   1 
ATOM   1326 C  C    . ALA   A 1 196 ? -30.95718 -32.87610 14.02010  1.000 29.79162 ? 201  ALA   A C    1 
ATOM   1327 O  O    . ALA   A 1 196 ? -31.03017 -34.04515 13.62623  1.000 33.17229 ? 201  ALA   A O    1 
ATOM   1328 C  CB   . ALA   A 1 196 ? -30.75821 -32.30183 16.46204  1.000 33.08758 ? 201  ALA   A CB   1 
ATOM   1329 N  N    . SER   A 1 197 ? -31.70516 -31.90516 13.49298  1.000 29.37658 ? 202  SER   A N    1 
ATOM   1330 C  CA   . SER   A 1 197 ? -32.71615 -32.20927 12.49100  1.000 28.50793 ? 202  SER   A CA   1 
ATOM   1331 C  C    . SER   A 1 197 ? -32.20013 -32.11642 11.06400  1.000 33.00891 ? 202  SER   A C    1 
ATOM   1332 O  O    . SER   A 1 197 ? -32.81211 -32.69952 10.16605  1.000 31.88963 ? 202  SER   A O    1 
ATOM   1333 C  CB   . SER   A 1 197 ? -33.91515 -31.27024 12.64788  1.000 30.26344 ? 202  SER   A CB   1 
ATOM   1334 O  OG   . SER   A 1 197 ? -33.57714 -29.93628 12.30274  1.000 27.54966 ? 202  SER   A OG   1 
ATOM   1335 N  N    . GLY   A 1 198 ? -31.10112 -31.39745 10.83194  1.000 28.63414 ? 203  GLY   A N    1 
ATOM   1336 C  CA   . GLY   A 1 198 ? -30.65610 -31.11661 9.48191   1.000 25.07711 ? 203  GLY   A CA   1 
ATOM   1337 C  C    . GLY   A 1 198 ? -31.45408 -30.04768 8.77178   1.000 32.63324 ? 203  GLY   A C    1 
ATOM   1338 O  O    . GLY   A 1 198 ? -31.24206 -29.82981 7.57076   1.000 29.65876 ? 203  GLY   A O    1 
ATOM   1339 N  N    . GLN   A 1 199 ? -32.35809 -29.37160 9.47569   1.000 27.19593 ? 204  GLN   A N    1 
ATOM   1340 C  CA   . GLN   A 1 199 ? -33.18208 -28.33666 8.86257   1.000 29.42982 ? 204  GLN   A CA   1 
ATOM   1341 C  C    . GLN   A 1 199 ? -32.36207 -27.07470 8.59944   1.000 25.41149 ? 204  GLN   A C    1 
ATOM   1342 O  O    . GLN   A 1 199 ? -31.53908 -26.66361 9.42241   1.000 25.65630 ? 204  GLN   A O    1 
ATOM   1343 C  CB   . GLN   A 1 199 ? -34.37709 -28.01056 9.76751   1.000 25.59824 ? 204  GLN   A CB   1 
ATOM   1344 C  CG   . GLN   A 1 199 ? -35.31808 -26.92462 9.20938   1.000 40.19282 ? 204  GLN   A CG   1 
ATOM   1345 C  CD   . GLN   A 1 199 ? -36.41909 -26.44951 10.19231  1.000 50.04146 ? 204  GLN   A CD   1 
ATOM   1346 O  OE1  . GLN   A 1 199 ? -36.43711 -26.81037 11.37435  1.000 50.04283 ? 204  GLN   A OE1  1 
ATOM   1347 N  NE2  . GLN   A 1 199 ? -37.33708 -25.62556 9.68520   1.000 53.36113 ? 204  GLN   A NE2  1 
ATOM   1348 N  N    . CYS   A 1 200 ? -32.58905 -26.45382 7.44137   1.000 22.40855 ? 205  CYS   A N    1 
ATOM   1349 C  CA   . CYS   A 1 200 ? -32.00404 -25.14385 7.18923   1.000 25.10464 ? 205  CYS   A CA   1 
ATOM   1350 C  C    . CYS   A 1 200 ? -32.76005 -24.09176 7.99610   1.000 28.46580 ? 205  CYS   A C    1 
ATOM   1351 O  O    . CYS   A 1 200 ? -33.98305 -23.97677 7.88007   1.000 24.33969 ? 205  CYS   A O    1 
ATOM   1352 C  CB   . CYS   A 1 200 ? -32.03701 -24.81202 5.70019   1.000 22.38018 ? 205  CYS   A CB   1 
ATOM   1353 S  SG   . CYS   A 1 200 ? -31.09700 -23.32106 5.30705   1.000 26.81472 ? 205  CYS   A SG   1 
ATOM   1354 N  N    . LEU   A 1 201 ? -32.03706 -23.32867 8.81803   1.000 26.51878 ? 206  LEU   A N    1 
ATOM   1355 C  CA   . LEU   A 1 201 ? -32.64707 -22.32858 9.67891   1.000 26.46824 ? 206  LEU   A CA   1 
ATOM   1356 C  C    . LEU   A 1 201 ? -32.37306 -20.90363 9.24176   1.000 31.55228 ? 206  LEU   A C    1 
ATOM   1357 O  O    . LEU   A 1 201 ? -32.94406 -19.97256 9.82365   1.000 29.17008 ? 206  LEU   A O    1 
ATOM   1358 C  CB   . LEU   A 1 201 ? -32.15809 -22.49942 11.11894  1.000 31.12935 ? 206  LEU   A CB   1 
ATOM   1359 C  CG   . LEU   A 1 201 ? -32.34910 -23.91236 11.64709  1.000 34.01807 ? 206  LEU   A CG   1 
ATOM   1360 C  CD1  . LEU   A 1 201 ? -31.63013 -24.06522 12.97612  1.000 33.59407 ? 206  LEU   A CD1  1 
ATOM   1361 C  CD2  . LEU   A 1 201 ? -33.84211 -24.21534 11.78610  1.000 32.13937 ? 206  LEU   A CD2  1 
ATOM   1362 N  N    . LYS   A 1 202 ? -31.51004 -20.69774 8.25175   1.000 23.08486 ? 207  LYS   A N    1 
ATOM   1363 C  CA   . LYS   A 1 202 ? -31.21303 -19.33378 7.85160   1.000 26.42552 ? 207  LYS   A CA   1 
ATOM   1364 C  C    . LYS   A 1 202 ? -30.46401 -19.37093 6.52962   1.000 24.02266 ? 207  LYS   A C    1 
ATOM   1365 O  O    . LYS   A 1 202 ? -29.61001 -20.23796 6.32573   1.000 22.92082 ? 207  LYS   A O    1 
ATOM   1366 C  CB   . LYS   A 1 202 ? -30.38004 -18.62567 8.93254   1.000 26.45565 ? 207  LYS   A CB   1 
ATOM   1367 C  CG   . LYS   A 1 202 ? -30.13503 -17.15470 8.65338   1.000 23.94639 ? 207  LYS   A CG   1 
ATOM   1368 C  CD   . LYS   A 1 202 ? -31.32204 -16.31465 9.05527   1.000 30.59439 ? 207  LYS   A CD   1 
ATOM   1369 C  CE   . LYS   A 1 202 ? -31.62006 -16.48649 10.52928  1.000 41.86542 ? 207  LYS   A CE   1 
ATOM   1370 N  NZ   . LYS   A 1 202 ? -32.73406 -15.60043 10.98417  1.000 50.23798 ? 207  LYS   A NZ   1 
ATOM   1371 N  N    . THR   A 1 203 ? -30.80699 -18.44703 5.63251   1.000 22.46697 ? 208  THR   A N    1 
ATOM   1372 C  CA   . THR   A 1 203 ? -30.03297 -18.17417 4.42549   1.000 24.61970 ? 208  THR   A CA   1 
ATOM   1373 C  C    . THR   A 1 203 ? -29.65696 -16.69917 4.44634   1.000 29.65871 ? 208  THR   A C    1 
ATOM   1374 O  O    . THR   A 1 203 ? -30.53496 -15.82416 4.42523   1.000 25.05111 ? 208  THR   A O    1 
ATOM   1375 C  CB   . THR   A 1 203 ? -30.81495 -18.52630 3.14852   1.000 21.31518 ? 208  THR   A CB   1 
ATOM   1376 O  OG1  . THR   A 1 203 ? -31.01695 -19.94831 3.06167   1.000 24.86754 ? 208  THR   A OG1  1 
ATOM   1377 C  CG2  . THR   A 1 203 ? -30.08493 -18.05244 1.90148   1.000 22.15723 ? 208  THR   A CG2  1 
ATOM   1378 N  N    . LEU   A 1 204 ? -28.36096 -16.41616 4.49333   1.000 26.20015 ? 209  LEU   A N    1 
ATOM   1379 C  CA   . LEU   A 1 204 ? -27.88596 -15.03916 4.51018   1.000 25.93046 ? 209  LEU   A CA   1 
ATOM   1380 C  C    . LEU   A 1 204 ? -27.47593 -14.63132 3.10614   1.000 27.03118 ? 209  LEU   A C    1 
ATOM   1381 O  O    . LEU   A 1 204 ? -26.73993 -15.35540 2.42323   1.000 25.29167 ? 209  LEU   A O    1 
ATOM   1382 C  CB   . LEU   A 1 204 ? -26.71997 -14.86506 5.48318   1.000 24.29777 ? 209  LEU   A CB   1 
ATOM   1383 C  CG   . LEU   A 1 204 ? -27.02600 -15.16590 6.96221   1.000 34.29161 ? 209  LEU   A CG   1 
ATOM   1384 C  CD1  . LEU   A 1 204 ? -25.79001 -14.92981 7.81220   1.000 34.76934 ? 209  LEU   A CD1  1 
ATOM   1385 C  CD2  . LEU   A 1 204 ? -28.20400 -14.33783 7.50310   1.000 30.62058 ? 209  LEU   A CD2  1 
ATOM   1386 N  N    . ILE   A 1 205 ? -27.96092 -13.47937 2.67101   1.000 27.20023 ? 210  ILE   A N    1 
ATOM   1387 C  CA   . ILE   A 1 205 ? -27.54290 -12.92151 1.39595   1.000 33.43378 ? 210  ILE   A CA   1 
ATOM   1388 C  C    . ILE   A 1 205 ? -27.71390 -11.41450 1.46878   1.000 37.28594 ? 210  ILE   A C    1 
ATOM   1389 O  O    . ILE   A 1 205 ? -28.71890 -10.91644 1.98671   1.000 35.36704 ? 210  ILE   A O    1 
ATOM   1390 C  CB   . ILE   A 1 205 ? -28.33388 -13.52664 0.22101   1.000 35.55261 ? 210  ILE   A CB   1 
ATOM   1391 C  CG1  . ILE   A 1 205 ? -27.98686 -12.79078 -1.06807  1.000 37.46087 ? 210  ILE   A CG1  1 
ATOM   1392 C  CG2  . ILE   A 1 205 ? -29.83089 -13.47560 0.49398   1.000 29.04720 ? 210  ILE   A CG2  1 
ATOM   1393 C  CD1  . ILE   A 1 205 ? -28.82884 -13.22091 -2.23003  1.000 33.00071 ? 210  ILE   A CD1  1 
ATOM   1394 N  N    . ASP   A 1 206 ? -26.71589 -10.69456 0.95572   1.000 27.48065 ? 211  ASP   A N    1 
ATOM   1395 C  CA   . ASP   A 1 206 ? -26.68488 -9.24055  1.01656   1.000 42.33757 ? 211  ASP   A CA   1 
ATOM   1396 C  C    . ASP   A 1 206 ? -27.19686 -8.68370  -0.30751  1.000 37.78562 ? 211  ASP   A C    1 
ATOM   1397 O  O    . ASP   A 1 206 ? -28.09585 -9.27176  -0.91846  1.000 43.77805 ? 211  ASP   A O    1 
ATOM   1398 C  CB   . ASP   A 1 206 ? -25.26088 -8.74553  1.33253   1.000 43.40843 ? 211  ASP   A CB   1 
ATOM   1399 C  CG   . ASP   A 1 206 ? -25.25189 -7.40544  2.08438   1.000 57.25042 ? 211  ASP   A CG   1 
ATOM   1400 O  OD1  . ASP   A 1 206 ? -26.34289 -6.81742  2.27030   1.000 51.09067 ? 211  ASP   A OD1  1 
ATOM   1401 O  OD2  . ASP   A 1 206 ? -24.15790 -6.93840  2.49935   1.000 52.57239 ? 211  ASP   A OD2  1 
ATOM   1402 N  N    . ASP   A 1 207 ? -26.62585 -7.57175  -0.77162  1.000 34.97233 ? 212  ASP   A N    1 
ATOM   1403 C  CA   . ASP   A 1 207 ? -27.07282 -6.90389  -1.99470  1.000 37.03145 ? 212  ASP   A CA   1 
ATOM   1404 C  C    . ASP   A 1 207 ? -26.52481 -7.54403  -3.25962  1.000 38.16049 ? 212  ASP   A C    1 
ATOM   1405 O  O    . ASP   A 1 207 ? -26.89379 -7.12915  -4.36368  1.000 34.91469 ? 212  ASP   A O    1 
ATOM   1406 C  CB   . ASP   A 1 207 ? -26.67982 -5.42488  -1.95486  1.000 41.08015 ? 212  ASP   A CB   1 
ATOM   1407 C  CG   . ASP   A 1 207 ? -25.29783 -5.21182  -1.35686  1.000 61.53595 ? 212  ASP   A CG   1 
ATOM   1408 O  OD1  . ASP   A 1 207 ? -24.45283 -6.13783  -1.43575  1.000 54.03566 ? 212  ASP   A OD1  1 
ATOM   1409 O  OD2  . ASP   A 1 207 ? -25.05883 -4.12476  -0.78398  1.000 82.16462 ? 212  ASP   A OD2  1 
ATOM   1410 N  N    . ASP   A 1 208 ? -25.65981 -8.54002  -3.12450  1.000 39.05111 ? 213  ASP   A N    1 
ATOM   1411 C  CA   . ASP   A 1 208 ? -25.14480 -9.29414  -4.25041  1.000 31.68353 ? 213  ASP   A CA   1 
ATOM   1412 C  C    . ASP   A 1 208 ? -24.78681 -10.68709 -3.74225  1.000 28.63224 ? 213  ASP   A C    1 
ATOM   1413 O  O    . ASP   A 1 208 ? -24.79783 -10.94395 -2.53622  1.000 34.87528 ? 213  ASP   A O    1 
ATOM   1414 C  CB   . ASP   A 1 208 ? -23.93879 -8.59821  -4.85847  1.000 34.13317 ? 213  ASP   A CB   1 
ATOM   1415 C  CG   . ASP   A 1 208 ? -23.65176 -9.06737  -6.25641  1.000 39.41204 ? 213  ASP   A CG   1 
ATOM   1416 O  OD1  . ASP   A 1 208 ? -24.44576 -9.87242  -6.78733  1.000 50.28807 ? 213  ASP   A OD1  1 
ATOM   1417 O  OD2  . ASP   A 1 208 ? -22.63875 -8.61844  -6.83044  1.000 53.37822 ? 213  ASP   A OD2  1 
ATOM   1418 N  N    . ASN   A 1 209 ? -24.44480 -11.59519 -4.65614  1.000 28.98642 ? 214  ASN   A N    1 
ATOM   1419 C  CA   . ASN   A 1 209 ? -24.08681 -12.95815 -4.25499  1.000 33.40875 ? 214  ASN   A CA   1 
ATOM   1420 C  C    . ASN   A 1 209 ? -22.83780 -13.45923 -4.98691  1.000 29.65134 ? 214  ASN   A C    1 
ATOM   1421 O  O    . ASN   A 1 209 ? -22.85279 -14.50230 -5.64380  1.000 26.50286 ? 214  ASN   A O    1 
ATOM   1422 C  CB   . ASN   A 1 209 ? -25.28081 -13.89716 -4.43690  1.000 38.28433 ? 214  ASN   A CB   1 
ATOM   1423 C  CG   . ASN   A 1 209 ? -25.74979 -13.97932 -5.85690  1.000 41.83448 ? 214  ASN   A CG   1 
ATOM   1424 O  OD1  . ASN   A 1 209 ? -26.09578 -12.97538 -6.47102  1.000 50.65521 ? 214  ASN   A OD1  1 
ATOM   1425 N  ND2  . ASN   A 1 209 ? -25.76279 -15.19138 -6.39677  1.000 52.79881 ? 214  ASN   A ND2  1 
ATOM   1426 N  N    . PRO   A 1 210 ? -21.71280 -12.76422 -4.82597  1.000 25.80559 ? 215  PRO   A N    1 
ATOM   1427 C  CA   . PRO   A 1 210 ? -20.42980 -13.36126 -5.20288  1.000 23.81429 ? 215  PRO   A CA   1 
ATOM   1428 C  C    . PRO   A 1 210 ? -20.19481 -14.63518 -4.42074  1.000 22.03440 ? 215  PRO   A C    1 
ATOM   1429 O  O    . PRO   A 1 210 ? -20.73783 -14.81706 -3.31373  1.000 19.61134 ? 215  PRO   A O    1 
ATOM   1430 C  CB   . PRO   A 1 210 ? -19.41380 -12.27623 -4.82299  1.000 27.85228 ? 215  PRO   A CB   1 
ATOM   1431 C  CG   . PRO   A 1 210 ? -20.06182 -11.58810 -3.65707  1.000 23.39394 ? 215  PRO   A CG   1 
ATOM   1432 C  CD   . PRO   A 1 210 ? -21.54181 -11.55013 -4.01110  1.000 25.33932 ? 215  PRO   A CD   1 
ATOM   1433 N  N    . PRO   A 1 211 ? -19.39981 -15.55724 -4.95663  1.000 19.51338 ? 216  PRO   A N    1 
ATOM   1434 C  CA   . PRO   A 1 211 ? -19.07783 -16.78416 -4.21549  1.000 22.06514 ? 216  PRO   A CA   1 
ATOM   1435 C  C    . PRO   A 1 211 ? -18.64485 -16.49300 -2.78251  1.000 22.51898 ? 216  PRO   A C    1 
ATOM   1436 O  O    . PRO   A 1 211 ? -17.81185 -15.61798 -2.53259  1.000 21.38650 ? 216  PRO   A O    1 
ATOM   1437 C  CB   . PRO   A 1 211 ? -17.93482 -17.39726 -5.03440  1.000 21.54846 ? 216  PRO   A CB   1 
ATOM   1438 C  CG   . PRO   A 1 211 ? -18.20979 -16.92641 -6.44546  1.000 24.44848 ? 216  PRO   A CG   1 
ATOM   1439 C  CD   . PRO   A 1 211 ? -18.76879 -15.52539 -6.29062  1.000 23.48337 ? 216  PRO   A CD   1 
ATOM   1440 N  N    . VAL   A 1 212 ? -19.22187 -17.23890 -1.84044  1.000 18.20753 ? 217  VAL   A N    1 
ATOM   1441 C  CA   . VAL   A 1 212 ? -18.83589 -17.16774 -0.43644  1.000 17.06063 ? 217  VAL   A CA   1 
ATOM   1442 C  C    . VAL   A 1 212 ? -17.76089 -18.22073 -0.23031  1.000 21.36078 ? 217  VAL   A C    1 
ATOM   1443 O  O    . VAL   A 1 212 ? -18.04190 -19.42273 -0.28418  1.000 20.96528 ? 217  VAL   A O    1 
ATOM   1444 C  CB   . VAL   A 1 212 ? -20.01790 -17.39264 0.51557   1.000 19.63861 ? 217  VAL   A CB   1 
ATOM   1445 C  CG1  . VAL   A 1 212 ? -19.56992 -17.11848 1.93354   1.000 18.36574 ? 217  VAL   A CG1  1 
ATOM   1446 C  CG2  . VAL   A 1 212 ? -21.20289 -16.47067 0.15745   1.000 19.99753 ? 217  VAL   A CG2  1 
ATOM   1447 N  N    . SER   A 1 213 ? -16.52590 -17.75771 -0.01034  1.000 19.29972 ? 218  SER   A N    1 
ATOM   1448 C  CA   . SER   A 1 213 ? -15.33690 -18.59371 -0.03123  1.000 17.96714 ? 218  SER   A CA   1 
ATOM   1449 C  C    . SER   A 1 213 ? -14.91092 -19.07056 1.34683   1.000 22.06705 ? 218  SER   A C    1 
ATOM   1450 O  O    . SER   A 1 213 ? -14.03193 -19.92855 1.44694   1.000 20.02726 ? 218  SER   A O    1 
ATOM   1451 C  CB   . SER   A 1 213 ? -14.19589 -17.81979 -0.68829  1.000 20.20682 ? 218  SER   A CB   1 
ATOM   1452 O  OG   . SER   A 1 213 ? -14.08789 -16.52673 -0.11643  1.000 18.18866 ? 218  SER   A OG   1 
ATOM   1453 N  N    . PHE   A 1 214 ? -15.52494 -18.55344 2.40477   1.000 19.37415 ? 219  PHE   A N    1 
ATOM   1454 C  CA   . PHE   A 1 214 ? -15.16896 -18.90529 3.77081   1.000 20.94231 ? 219  PHE   A CA   1 
ATOM   1455 C  C    . PHE   A 1 214 ? -16.25797 -18.40919 4.71474   1.000 21.57912 ? 219  PHE   A C    1 
ATOM   1456 O  O    . PHE   A 1 214 ? -16.80497 -17.32521 4.50461   1.000 19.68175 ? 219  PHE   A O    1 
ATOM   1457 C  CB   . PHE   A 1 214 ? -13.84097 -18.27025 4.18876   1.000 17.95114 ? 219  PHE   A CB   1 
ATOM   1458 C  CG   . PHE   A 1 214 ? -13.56499 -18.44109 5.65579   1.000 20.32019 ? 219  PHE   A CG   1 
ATOM   1459 C  CD1  . PHE   A 1 214 ? -13.12400 -19.66204 6.14093   1.000 19.98790 ? 219  PHE   A CD1  1 
ATOM   1460 C  CD2  . PHE   A 1 214 ? -13.82000 -17.41699 6.54967   1.000 23.47619 ? 219  PHE   A CD2  1 
ATOM   1461 C  CE1  . PHE   A 1 214 ? -12.90502 -19.86189 7.49695   1.000 24.80483 ? 219  PHE   A CE1  1 
ATOM   1462 C  CE2  . PHE   A 1 214 ? -13.59202 -17.60384 7.90869   1.000 24.52691 ? 219  PHE   A CE2  1 
ATOM   1463 C  CZ   . PHE   A 1 214 ? -13.13503 -18.83379 8.37484   1.000 22.50735 ? 219  PHE   A CZ   1 
ATOM   1464 N  N    . VAL   A 1 215 ? -16.52599 -19.17207 5.77582   1.000 18.99582 ? 220  VAL   A N    1 
ATOM   1465 C  CA   . VAL   A 1 215 ? -17.38201 -18.68494 6.85775   1.000 22.15418 ? 220  VAL   A CA   1 
ATOM   1466 C  C    . VAL   A 1 215 ? -17.03303 -19.42380 8.14084   1.000 20.62813 ? 220  VAL   A C    1 
ATOM   1467 O  O    . VAL   A 1 215 ? -16.56204 -20.56281 8.11397   1.000 21.58166 ? 220  VAL   A O    1 
ATOM   1468 C  CB   . VAL   A 1 215 ? -18.88800 -18.84798 6.53075   1.000 21.54512 ? 220  VAL   A CB   1 
ATOM   1469 C  CG1  . VAL   A 1 215 ? -19.28001 -20.33197 6.52790   1.000 18.88924 ? 220  VAL   A CG1  1 
ATOM   1470 C  CG2  . VAL   A 1 215 ? -19.73702 -18.03186 7.50564   1.000 26.02599 ? 220  VAL   A CG2  1 
ATOM   1471 N  N    . LYS   A 1 216 ? -17.26605 -18.75968 9.27976   1.000 21.40852 ? 221  LYS   A N    1 
ATOM   1472 C  CA   . LYS   A 1 216 ? -17.16407 -19.40153 10.58283  1.000 22.13953 ? 221  LYS   A CA   1 
ATOM   1473 C  C    . LYS   A 1 216 ? -17.93908 -18.56942 11.60473  1.000 22.01491 ? 221  LYS   A C    1 
ATOM   1474 O  O    . LYS   A 1 216 ? -18.13008 -17.36244 11.42559  1.000 24.53290 ? 221  LYS   A O    1 
ATOM   1475 C  CB   . LYS   A 1 216 ? -15.70008 -19.56149 11.02488  1.000 22.98659 ? 221  LYS   A CB   1 
ATOM   1476 C  CG   . LYS   A 1 216 ? -15.12308 -18.27243 11.55774  1.000 28.27939 ? 221  LYS   A CG   1 
ATOM   1477 C  CD   . LYS   A 1 216 ? -13.59909 -18.34542 11.74277  1.000 32.38429 ? 221  LYS   A CD   1 
ATOM   1478 C  CE   . LYS   A 1 216 ? -13.17710 -19.49732 12.63491  1.000 37.99000 ? 221  LYS   A CE   1 
ATOM   1479 N  NZ   . LYS   A 1 216 ? -11.69011 -19.48530 12.85893  1.000 37.49393 ? 221  LYS   A NZ   1 
ATOM   1480 N  N    . PHE   A 1 217 ? -18.40410 -19.23630 12.66080  1.000 20.05355 ? 222  PHE   A N    1 
ATOM   1481 C  CA   . PHE   A 1 217 ? -18.97612 -18.56017 13.82671  1.000 28.38520 ? 222  PHE   A CA   1 
ATOM   1482 C  C    . PHE   A 1 217 ? -17.90613 -17.82908 14.62865  1.000 29.47515 ? 222  PHE   A C    1 
ATOM   1483 O  O    . PHE   A 1 217 ? -16.76013 -18.28308 14.74172  1.000 25.89468 ? 222  PHE   A O    1 
ATOM   1484 C  CB   . PHE   A 1 217 ? -19.64614 -19.56606 14.76181  1.000 24.78361 ? 222  PHE   A CB   1 
ATOM   1485 C  CG   . PHE   A 1 217 ? -20.94413 -20.09711 14.25285  1.000 26.61893 ? 222  PHE   A CG   1 
ATOM   1486 C  CD1  . PHE   A 1 217 ? -22.08413 -19.30711 14.28275  1.000 23.03655 ? 222  PHE   A CD1  1 
ATOM   1487 C  CD2  . PHE   A 1 217 ? -21.03413 -21.38917 13.76599  1.000 25.10380 ? 222  PHE   A CD2  1 
ATOM   1488 C  CE1  . PHE   A 1 217 ? -23.30312 -19.79015 13.83378  1.000 26.40645 ? 222  PHE   A CE1  1 
ATOM   1489 C  CE2  . PHE   A 1 217 ? -22.25212 -21.88621 13.31103  1.000 22.76963 ? 222  PHE   A CE2  1 
ATOM   1490 C  CZ   . PHE   A 1 217 ? -23.39412 -21.07721 13.34992  1.000 26.42450 ? 222  PHE   A CZ   1 
ATOM   1491 N  N    . SER   A 1 218 ? -18.30214 -16.70302 15.22952  1.000 28.78979 ? 223  SER   A N    1 
ATOM   1492 C  CA   . SER   A 1 218 ? -17.44715 -16.04591 16.21246  1.000 31.56349 ? 223  SER   A CA   1 
ATOM   1493 C  C    . SER   A 1 218 ? -17.30917 -16.91277 17.46556  1.000 33.99345 ? 223  SER   A C    1 
ATOM   1494 O  O    . SER   A 1 218 ? -18.15118 -17.77374 17.73964  1.000 28.17359 ? 223  SER   A O    1 
ATOM   1495 C  CB   . SER   A 1 218 ? -18.00115 -14.67087 16.59030  1.000 29.21264 ? 223  SER   A CB   1 
ATOM   1496 O  OG   . SER   A 1 218 ? -19.29416 -14.77580 17.17129  1.000 29.14277 ? 223  SER   A OG   1 
ATOM   1497 N  N    . PRO   A 1 219 ? -16.24018 -16.70969 18.23555  1.000 34.08001 ? 224  PRO   A N    1 
ATOM   1498 C  CA   . PRO   A 1 219 ? -16.05721 -17.51256 19.45564  1.000 34.29756 ? 224  PRO   A CA   1 
ATOM   1499 C  C    . PRO   A 1 219 ? -17.26722 -17.49545 20.36862  1.000 34.91997 ? 224  PRO   A C    1 
ATOM   1500 O  O    . PRO   A 1 219 ? -17.61123 -18.53139 20.94973  1.000 38.40489 ? 224  PRO   A O    1 
ATOM   1501 C  CB   . PRO   A 1 219 ? -14.83221 -16.86749 20.11059  1.000 36.19563 ? 224  PRO   A CB   1 
ATOM   1502 C  CG   . PRO   A 1 219 ? -14.06519 -16.28962 18.95154  1.000 36.09205 ? 224  PRO   A CG   1 
ATOM   1503 C  CD   . PRO   A 1 219 ? -15.09418 -15.82273 17.96447  1.000 28.64678 ? 224  PRO   A CD   1 
ATOM   1504 N  N    . ASN   A 1 220 ? -17.92622 -16.35144 20.50649  1.000 33.04381 ? 225  ASN   A N    1 
ATOM   1505 C  CA   . ASN   A 1 220 ? -19.09023 -16.25033 21.37646  1.000 45.66253 ? 225  ASN   A CA   1 
ATOM   1506 C  C    . ASN   A 1 220 ? -20.36522 -16.77940 20.72749  1.000 45.49818 ? 225  ASN   A C    1 
ATOM   1507 O  O    . ASN   A 1 220 ? -21.41323 -16.79533 21.38048  1.000 41.87257 ? 225  ASN   A O    1 
ATOM   1508 C  CB   . ASN   A 1 220 ? -19.28323 -14.79328 21.83129  1.000 40.19943 ? 225  ASN   A CB   1 
ATOM   1509 C  CG   . ASN   A 1 220 ? -19.76521 -13.87041 20.71118  1.000 50.37376 ? 225  ASN   A CG   1 
ATOM   1510 O  OD1  . ASN   A 1 220 ? -20.20020 -14.32252 19.65123  1.000 47.37613 ? 225  ASN   A OD1  1 
ATOM   1511 N  ND2  . ASN   A 1 220 ? -19.69921 -12.56338 20.95404  1.000 51.13013 ? 225  ASN   A ND2  1 
ATOM   1512 N  N    . GLY   A 1 221 ? -20.30120 -17.20754 19.46654  1.000 44.13043 ? 226  GLY   A N    1 
ATOM   1513 C  CA   . GLY   A 1 221 ? -21.44020 -17.79361 18.79059  1.000 34.49127 ? 226  GLY   A CA   1 
ATOM   1514 C  C    . GLY   A 1 221 ? -22.49318 -16.81366 18.32646  1.000 41.51372 ? 226  GLY   A C    1 
ATOM   1515 O  O    . GLY   A 1 221 ? -23.50318 -17.24872 17.75650  1.000 48.53683 ? 226  GLY   A O    1 
ATOM   1516 N  N    . LYS   A 1 222 ? -22.29318 -15.50964 18.54032  1.000 34.34801 ? 227  LYS   A N    1 
ATOM   1517 C  CA   . LYS   A 1 222 ? -23.29917 -14.52267 18.16020  1.000 42.47244 ? 227  LYS   A CA   1 
ATOM   1518 C  C    . LYS   A 1 222 ? -23.22115 -14.14784 16.68616  1.000 40.97197 ? 227  LYS   A C    1 
ATOM   1519 O  O    . LYS   A 1 222 ? -24.24414 -13.79690 16.08210  1.000 36.96067 ? 227  LYS   A O    1 
ATOM   1520 C  CB   . LYS   A 1 222 ? -23.15018 -13.24658 18.99606  1.000 49.90118 ? 227  LYS   A CB   1 
ATOM   1521 C  CG   . LYS   A 1 222 ? -22.91121 -13.45142 20.49409  1.000 55.63161 ? 227  LYS   A CG   1 
ATOM   1522 C  CD   . LYS   A 1 222 ? -24.15622 -13.91033 21.24812  1.000 61.99240 ? 227  LYS   A CD   1 
ATOM   1523 C  CE   . LYS   A 1 222 ? -24.33824 -13.10519 22.54202  1.000 61.12098 ? 227  LYS   A CE   1 
ATOM   1524 N  NZ   . LYS   A 1 222 ? -23.04324 -12.58613 23.08699  1.000 57.03261 ? 227  LYS   A NZ   1 
ATOM   1525 N  N    . TYR   A 1 223 ? -22.03114 -14.19291 16.10018  1.000 32.23140 ? 228  TYR   A N    1 
ATOM   1526 C  CA   . TYR   A 1 223 ? -21.79812 -13.68506 14.75913  1.000 34.88309 ? 228  TYR   A CA   1 
ATOM   1527 C  C    . TYR   A 1 223 ? -21.23511 -14.78616 13.87526  1.000 30.75671 ? 228  TYR   A C    1 
ATOM   1528 O  O    . TYR   A 1 223 ? -20.77812 -15.83510 14.34638  1.000 28.10586 ? 228  TYR   A O    1 
ATOM   1529 C  CB   . TYR   A 1 223 ? -20.82911 -12.49306 14.78001  1.000 33.79058 ? 228  TYR   A CB   1 
ATOM   1530 C  CG   . TYR   A 1 223 ? -21.19813 -11.47394 15.82289  1.000 39.04384 ? 228  TYR   A CG   1 
ATOM   1531 C  CD1  . TYR   A 1 223 ? -22.40812 -10.79694 15.75080  1.000 39.45182 ? 228  TYR   A CD1  1 
ATOM   1532 C  CD2  . TYR   A 1 223 ? -20.35314 -11.20283 16.89388  1.000 46.30833 ? 228  TYR   A CD2  1 
ATOM   1533 C  CE1  . TYR   A 1 223 ? -22.76613 -9.86484  16.70769  1.000 46.74138 ? 228  TYR   A CE1  1 
ATOM   1534 C  CE2  . TYR   A 1 223 ? -20.70415 -10.26972 17.86077  1.000 51.31709 ? 228  TYR   A CE2  1 
ATOM   1535 C  CZ   . TYR   A 1 223 ? -21.91515 -9.60472  17.75968  1.000 46.12183 ? 228  TYR   A CZ   1 
ATOM   1536 O  OH   . TYR   A 1 223 ? -22.28616 -8.67662  18.70457  1.000 54.76931 ? 228  TYR   A OH   1 
ATOM   1537 N  N    . ILE   A 1 224 ? -21.27308 -14.52630 12.57623  1.000 30.45894 ? 229  ILE   A N    1 
ATOM   1538 C  CA   . ILE   A 1 224 ? -20.46407 -15.28441 11.63633  1.000 27.46421 ? 229  ILE   A CA   1 
ATOM   1539 C  C    . ILE   A 1 224 ? -19.59506 -14.29449 10.87323  1.000 25.11987 ? 229  ILE   A C    1 
ATOM   1540 O  O    . ILE   A 1 224 ? -19.94205 -13.12251 10.70010  1.000 23.80685 ? 229  ILE   A O    1 
ATOM   1541 C  CB   . ILE   A 1 224 ? -21.31606 -16.15251 10.68041  1.000 27.61968 ? 229  ILE   A CB   1 
ATOM   1542 C  CG1  . ILE   A 1 224 ? -22.27704 -15.27659 9.88030   1.000 32.36631 ? 229  ILE   A CG1  1 
ATOM   1543 C  CG2  . ILE   A 1 224 ? -22.10908 -17.20242 11.46851  1.000 28.99919 ? 229  ILE   A CG2  1 
ATOM   1544 C  CD1  . ILE   A 1 224 ? -22.28802 -15.58276 8.40433   1.000 36.61746 ? 229  ILE   A CD1  1 
ATOM   1545 N  N    . LEU   A 1 225 ? -18.43305 -14.77354 10.46030  1.000 24.00628 ? 230  LEU   A N    1 
ATOM   1546 C  CA   . LEU   A 1 225 ? -17.49504 -14.02064 9.64723   1.000 22.26851 ? 230  LEU   A CA   1 
ATOM   1547 C  C    . LEU   A 1 225 ? -17.43802 -14.70879 8.29631   1.000 22.95613 ? 230  LEU   A C    1 
ATOM   1548 O  O    . LEU   A 1 225 ? -17.17002 -15.91679 8.23045   1.000 22.84907 ? 230  LEU   A O    1 
ATOM   1549 C  CB   . LEU   A 1 225 ? -16.11005 -14.00257 10.30025  1.000 22.45111 ? 230  LEU   A CB   1 
ATOM   1550 C  CG   . LEU   A 1 225 ? -14.99603 -13.29166 9.53819   1.000 22.18569 ? 230  LEU   A CG   1 
ATOM   1551 C  CD1  . LEU   A 1 225 ? -15.28502 -11.80967 9.44503   1.000 25.54955 ? 230  LEU   A CD1  1 
ATOM   1552 C  CD2  . LEU   A 1 225 ? -13.64804 -13.54159 10.21324  1.000 25.01839 ? 230  LEU   A CD2  1 
ATOM   1553 N  N    . ALA   A 1 226 ? -17.69200 -13.95590 7.22522   1.000 20.08504 ? 231  ALA   A N    1 
ATOM   1554 C  CA   . ALA   A 1 226 ? -17.84098 -14.56105 5.90629   1.000 22.73245 ? 231  ALA   A CA   1 
ATOM   1555 C  C    . ALA   A 1 226 ? -16.97596 -13.81516 4.90722   1.000 21.87715 ? 231  ALA   A C    1 
ATOM   1556 O  O    . ALA   A 1 226 ? -17.00195 -12.58017 4.86608   1.000 24.82617 ? 231  ALA   A O    1 
ATOM   1557 C  CB   . ALA   A 1 226 ? -19.30997 -14.55209 5.44526   1.000 20.86046 ? 231  ALA   A CB   1 
ATOM   1558 N  N    . ALA   A 1 227 ? -16.22895 -14.56425 4.09531   1.000 21.26925 ? 232  ALA   A N    1 
ATOM   1559 C  CA   . ALA   A 1 227 ? -15.44993 -13.99338 3.00926   1.000 22.54484 ? 232  ALA   A CA   1 
ATOM   1560 C  C    . ALA   A 1 227 ? -16.17391 -14.22652 1.68828   1.000 16.77293 ? 232  ALA   A C    1 
ATOM   1561 O  O    . ALA   A 1 227 ? -16.73391 -15.30654 1.45139   1.000 20.09824 ? 232  ALA   A O    1 
ATOM   1562 C  CB   . ALA   A 1 227 ? -14.04893 -14.61339 2.94536   1.000 19.43458 ? 232  ALA   A CB   1 
ATOM   1563 N  N    . THR   A 1 228 ? -16.13089 -13.22562 0.81317   1.000 19.08022 ? 233  THR   A N    1 
ATOM   1564 C  CA   . THR   A 1 228 ? -16.63087 -13.38876 -0.54182  1.000 22.45026 ? 233  THR   A CA   1 
ATOM   1565 C  C    . THR   A 1 228 ? -15.53985 -13.04188 -1.54784  1.000 22.60618 ? 233  THR   A C    1 
ATOM   1566 O  O    . THR   A 1 228 ? -14.62486 -12.25885 -1.26891  1.000 22.99558 ? 233  THR   A O    1 
ATOM   1567 C  CB   . THR   A 1 228 ? -17.88086 -12.53179 -0.79194  1.000 24.10270 ? 233  THR   A CB   1 
ATOM   1568 O  OG1  . THR   A 1 228 ? -17.71587 -11.24472 -0.18008  1.000 22.82907 ? 233  THR   A OG1  1 
ATOM   1569 C  CG2  . THR   A 1 228 ? -19.12188 -13.21972 -0.22288  1.000 19.65453 ? 233  THR   A CG2  1 
ATOM   1570 N  N    . LEU   A 1 229 ? -15.63384 -13.65001 -2.72178  1.000 20.27086 ? 234  LEU   A N    1 
ATOM   1571 C  CA   . LEU   A 1 229 ? -14.59382 -13.49112 -3.72878  1.000 19.53244 ? 234  LEU   A CA   1 
ATOM   1572 C  C    . LEU   A 1 229 ? -14.70680 -12.15720 -4.45693  1.000 23.54470 ? 234  LEU   A C    1 
ATOM   1573 O  O    . LEU   A 1 229 ? -14.47579 -12.07234 -5.65893  1.000 23.59377 ? 234  LEU   A O    1 
ATOM   1574 C  CB   . LEU   A 1 229 ? -14.63481 -14.67623 -4.69465  1.000 21.66817 ? 234  LEU   A CB   1 
ATOM   1575 C  CG   . LEU   A 1 229 ? -14.18683 -16.00516 -4.06149  1.000 20.90244 ? 234  LEU   A CG   1 
ATOM   1576 C  CD1  . LEU   A 1 229 ? -14.05681 -17.12228 -5.09737  1.000 23.77343 ? 234  LEU   A CD1  1 
ATOM   1577 C  CD2  . LEU   A 1 229 ? -12.83184 -15.84208 -3.30849  1.000 22.89097 ? 234  LEU   A CD2  1 
ATOM   1578 N  N    . ASP   A 1 230 ? -15.08781 -11.10812 -3.73305  1.000 25.70188 ? 235  ASP   A N    1 
ATOM   1579 C  CA   . ASP   A 1 230 ? -15.02080 -9.72317  -4.18620  1.000 31.09098 ? 235  ASP   A CA   1 
ATOM   1580 C  C    . ASP   A 1 230 ? -14.11081 -8.91107  -3.26628  1.000 27.76876 ? 235  ASP   A C    1 
ATOM   1581 O  O    . ASP   A 1 230 ? -14.33481 -7.71605  -3.02841  1.000 24.75260 ? 235  ASP   A O    1 
ATOM   1582 C  CB   . ASP   A 1 230 ? -16.41680 -9.10018  -4.25429  1.000 26.20812 ? 235  ASP   A CB   1 
ATOM   1583 C  CG   . ASP   A 1 230 ? -17.12982 -9.12403  -2.92430  1.000 30.73527 ? 235  ASP   A CG   1 
ATOM   1584 O  OD1  . ASP   A 1 230 ? -16.54884 -9.61592  -1.92124  1.000 24.88281 ? 235  ASP   A OD1  1 
ATOM   1585 O  OD2  . ASP   A 1 230 ? -18.28182 -8.64502  -2.87737  1.000 31.09264 ? 235  ASP   A OD2  1 
ATOM   1586 N  N    . ASN   A 1 231 ? -13.09882 -9.57002  -2.71219  1.000 23.64740 ? 236  ASN   A N    1 
ATOM   1587 C  CA   . ASN   A 1 231 ? -12.10883 -8.91193  -1.85824  1.000 24.34873 ? 236  ASN   A CA   1 
ATOM   1588 C  C    . ASN   A 1 231 ? -12.74585 -8.36578  -0.58631  1.000 26.21410 ? 236  ASN   A C    1 
ATOM   1589 O  O    . ASN   A 1 231 ? -12.38186 -7.29473  -0.10243  1.000 28.45364 ? 236  ASN   A O    1 
ATOM   1590 C  CB   . ASN   A 1 231 ? -11.38782 -7.79501  -2.62236  1.000 25.63589 ? 236  ASN   A CB   1 
ATOM   1591 C  CG   . ASN   A 1 231 ? -10.94580 -8.23117  -4.00330  1.000 29.47730 ? 236  ASN   A CG   1 
ATOM   1592 O  OD1  . ASN   A 1 231 ? -10.03780 -9.06219  -4.14619  1.000 28.22580 ? 236  ASN   A OD1  1 
ATOM   1593 N  ND2  . ASN   A 1 231 ? -11.57978 -7.67228  -5.03437  1.000 27.47901 ? 236  ASN   A ND2  1 
ATOM   1594 N  N    . THR   A 1 232 ? -13.69686 -9.10272  -0.01725  1.000 24.81978 ? 237  THR   A N    1 
ATOM   1595 C  CA   . THR   A 1 232 ? -14.42888 -8.55559  1.11268   1.000 22.06043 ? 237  THR   A CA   1 
ATOM   1596 C  C    . THR   A 1 232 ? -14.68090 -9.60147  2.19279   1.000 24.03435 ? 237  THR   A C    1 
ATOM   1597 O  O    . THR   A 1 232 ? -15.02490 -10.75250 1.89391   1.000 23.63229 ? 237  THR   A O    1 
ATOM   1598 C  CB   . THR   A 1 232 ? -15.76987 -7.96264  0.63059   1.000 26.83888 ? 237  THR   A CB   1 
ATOM   1599 O  OG1  . THR   A 1 232 ? -15.53185 -7.08276  -0.47850  1.000 26.32288 ? 237  THR   A OG1  1 
ATOM   1600 C  CG2  . THR   A 1 232 ? -16.44788 -7.19751  1.74150   1.000 28.19084 ? 237  THR   A CG2  1 
ATOM   1601 N  N    . LEU   A 1 233 ? -14.49992 -9.17933  3.44975   1.000 22.36978 ? 238  LEU   A N    1 
ATOM   1602 C  CA   A LEU   A 1 233 ? -14.94194 -9.92520  4.61882   0.815 24.28837 ? 238  LEU   A CA   1 
ATOM   1603 C  CA   B LEU   A 1 233 ? -14.93894 -9.92220  4.62382   0.185 24.31389 ? 238  LEU   A CA   1 
ATOM   1604 C  C    . LEU   A 1 233 ? -16.09095 -9.17912  5.27672   1.000 25.46438 ? 238  LEU   A C    1 
ATOM   1605 O  O    . LEU   A 1 233 ? -16.09994 -7.94412  5.30659   1.000 23.30321 ? 238  LEU   A O    1 
ATOM   1606 C  CB   A LEU   A 1 233 ? -13.80496 -10.10709 5.62386   0.815 25.24723 ? 238  LEU   A CB   1 
ATOM   1607 C  CB   B LEU   A 1 233 ? -13.81696 -10.09409 5.65086   0.185 25.22287 ? 238  LEU   A CB   1 
ATOM   1608 C  CG   A LEU   A 1 233 ? -12.76595 -11.12915 5.19099   0.815 24.98248 ? 238  LEU   A CG   1 
ATOM   1609 C  CG   B LEU   A 1 233 ? -12.84596 -11.24412 5.43100   0.185 25.30245 ? 238  LEU   A CG   1 
ATOM   1610 C  CD1  A LEU   A 1 233 ? -11.43596 -10.75208 5.80997   0.815 25.31782 ? 238  LEU   A CD1  1 
ATOM   1611 C  CD1  B LEU   A 1 233 ? -12.10094 -10.99926 4.15399   0.185 25.03139 ? 238  LEU   A CD1  1 
ATOM   1612 C  CD2  A LEU   A 1 233 ? -13.22497 -12.52609 5.64614   0.815 24.89850 ? 238  LEU   A CD2  1 
ATOM   1613 C  CD2  B LEU   A 1 233 ? -11.89298 -11.37799 6.61103   0.185 24.87598 ? 238  LEU   A CD2  1 
ATOM   1614 N  N    . LYS   A 1 234 ? -17.04696 -9.93006  5.82179   1.000 23.00773 ? 239  LYS   A N    1 
ATOM   1615 C  CA   . LYS   A 1 234 ? -18.21397 -9.33099  6.46171   1.000 26.42382 ? 239  LYS   A CA   1 
ATOM   1616 C  C    . LYS   A 1 234 ? -18.52799 -10.01484 7.78178   1.000 23.89762 ? 239  LYS   A C    1 
ATOM   1617 O  O    . LYS   A 1 234 ? -18.55200 -11.24483 7.86691   1.000 22.55977 ? 239  LYS   A O    1 
ATOM   1618 C  CB   . LYS   A 1 234 ? -19.43495 -9.39108  5.53569   1.000 27.06615 ? 239  LYS   A CB   1 
ATOM   1619 C  CG   . LYS   A 1 234 ? -19.32093 -8.41421  4.37759   1.000 26.89473 ? 239  LYS   A CG   1 
ATOM   1620 C  CD   . LYS   A 1 234 ? -20.56092 -8.42331  3.48257   1.000 28.13270 ? 239  LYS   A CD   1 
ATOM   1621 C  CE   . LYS   A 1 234 ? -20.44490 -7.35943  2.40145   1.000 35.97524 ? 239  LYS   A CE   1 
ATOM   1622 N  NZ   . LYS   A 1 234 ? -21.39088 -7.61454  1.28747   1.000 44.30811 ? 239  LYS   A NZ   1 
ATOM   1623 N  N    . LEU   A 1 235 ? -18.79200 -9.21972  8.80768   1.000 24.86843 ? 240  LEU   A N    1 
ATOM   1624 C  CA   . LEU   A 1 235 ? -19.26503 -9.74458  10.07573  1.000 23.88348 ? 240  LEU   A CA   1 
ATOM   1625 C  C    . LEU   A 1 235 ? -20.78103 -9.60957  10.11770  1.000 28.33312 ? 240  LEU   A C    1 
ATOM   1626 O  O    . LEU   A 1 235 ? -21.31802 -8.51559  9.93557   1.000 28.62395 ? 240  LEU   A O    1 
ATOM   1627 C  CB   . LEU   A 1 235 ? -18.62104 -9.00445  11.24866  1.000 23.94262 ? 240  LEU   A CB   1 
ATOM   1628 C  CG   . LEU   A 1 235 ? -18.91907 -9.49830  12.66471  1.000 27.65248 ? 240  LEU   A CG   1 
ATOM   1629 C  CD1  . LEU   A 1 235 ? -18.31608 -10.88827 12.91788  1.000 25.35237 ? 240  LEU   A CD1  1 
ATOM   1630 C  CD2  . LEU   A 1 235 ? -18.40708 -8.47819  13.68161  1.000 28.28900 ? 240  LEU   A CD2  1 
ATOM   1631 N  N    . TRP   A 1 236 ? -21.46104 -10.72054 10.36481  1.000 26.31067 ? 241  TRP   A N    1 
ATOM   1632 C  CA   . TRP   A 1 236 ? -22.91103 -10.79955 10.27779  1.000 29.49708 ? 241  TRP   A CA   1 
ATOM   1633 C  C    . TRP   A 1 236 ? -23.50106 -11.10439 11.64582  1.000 33.08415 ? 241  TRP   A C    1 
ATOM   1634 O  O    . TRP   A 1 236 ? -22.99707 -11.97031 12.36992  1.000 28.17193 ? 241  TRP   A O    1 
ATOM   1635 C  CB   . TRP   A 1 236 ? -23.36002 -11.90065 9.29391   1.000 26.89891 ? 241  TRP   A CB   1 
ATOM   1636 C  CG   . TRP   A 1 236 ? -23.24600 -11.54981 7.84287   1.000 33.97592 ? 241  TRP   A CG   1 
ATOM   1637 C  CD1  . TRP   A 1 236 ? -22.10399 -11.52590 7.08589   1.000 32.55667 ? 241  TRP   A CD1  1 
ATOM   1638 C  CD2  . TRP   A 1 236 ? -24.31998 -11.19791 6.96081   1.000 32.49432 ? 241  TRP   A CD2  1 
ATOM   1639 N  NE1  . TRP   A 1 236 ? -22.40296 -11.15804 5.79684   1.000 29.11169 ? 241  TRP   A NE1  1 
ATOM   1640 C  CE2  . TRP   A 1 236 ? -23.75496 -10.95605 5.69280   1.000 35.76959 ? 241  TRP   A CE2  1 
ATOM   1641 C  CE3  . TRP   A 1 236 ? -25.70598 -11.05088 7.12478   1.000 42.01803 ? 241  TRP   A CE3  1 
ATOM   1642 C  CZ2  . TRP   A 1 236 ? -24.52694 -10.58217 4.58574   1.000 44.91078 ? 241  TRP   A CZ2  1 
ATOM   1643 C  CZ3  . TRP   A 1 236 ? -26.47597 -10.68200 6.02472   1.000 34.33906 ? 241  TRP   A CZ3  1 
ATOM   1644 C  CH2  . TRP   A 1 236 ? -25.88295 -10.45514 4.77171   1.000 39.13118 ? 241  TRP   A CH2  1 
ATOM   1645 N  N    . ASP   A 1 237 ? -24.58106 -10.40235 11.99272  1.000 33.99798 ? 242  ASP   A N    1 
ATOM   1646 C  CA   . ASP   A 1 237 ? -25.50608 -10.89423 13.01076  1.000 30.67260 ? 242  ASP   A CA   1 
ATOM   1647 C  C    . ASP   A 1 237 ? -26.46107 -11.84031 12.29485  1.000 34.28527 ? 242  ASP   A C    1 
ATOM   1648 O  O    . ASP   A 1 237 ? -27.36606 -11.40239 11.57979  1.000 35.44291 ? 242  ASP   A O    1 
ATOM   1649 C  CB   . ASP   A 1 237 ? -26.25208 -9.74916  13.68962  1.000 41.81086 ? 242  ASP   A CB   1 
ATOM   1650 C  CG   . ASP   A 1 237 ? -27.17710 -10.23503 14.79766  1.000 46.43893 ? 242  ASP   A CG   1 
ATOM   1651 O  OD1  . ASP   A 1 237 ? -27.71011 -11.36804 14.68878  1.000 35.93958 ? 242  ASP   A OD1  1 
ATOM   1652 O  OD2  . ASP   A 1 237 ? -27.35212 -9.48792  15.78558  1.000 47.61253 ? 242  ASP   A OD2  1 
ATOM   1653 N  N    . TYR   A 1 238 ? -26.24308 -13.14629 12.45100  1.000 30.72465 ? 243  TYR   A N    1 
ATOM   1654 C  CA   . TYR   A 1 238 ? -26.97007 -14.09638 11.61809  1.000 35.60431 ? 243  TYR   A CA   1 
ATOM   1655 C  C    . TYR   A 1 238 ? -28.40308 -14.29832 12.09509  1.000 39.82986 ? 243  TYR   A C    1 
ATOM   1656 O  O    . TYR   A 1 238 ? -29.27606 -14.62241 11.28411  1.000 38.76504 ? 243  TYR   A O    1 
ATOM   1657 C  CB   . TYR   A 1 238 ? -26.23407 -15.43939 11.55325  1.000 34.15480 ? 243  TYR   A CB   1 
ATOM   1658 C  CG   . TYR   A 1 238 ? -26.13410 -16.15025 12.88033  1.000 37.00063 ? 243  TYR   A CG   1 
ATOM   1659 C  CD1  . TYR   A 1 238 ? -27.18611 -16.92319 13.35340  1.000 36.72931 ? 243  TYR   A CD1  1 
ATOM   1660 C  CD2  . TYR   A 1 238 ? -24.99211 -16.04616 13.66434  1.000 33.78133 ? 243  TYR   A CD2  1 
ATOM   1661 C  CE1  . TYR   A 1 238 ? -27.10913 -17.57406 14.56847  1.000 36.64455 ? 243  TYR   A CE1  1 
ATOM   1662 C  CE2  . TYR   A 1 238 ? -24.90613 -16.69803 14.88441  1.000 37.07435 ? 243  TYR   A CE2  1 
ATOM   1663 C  CZ   . TYR   A 1 238 ? -25.97414 -17.45898 15.32848  1.000 39.51831 ? 243  TYR   A CZ   1 
ATOM   1664 O  OH   . TYR   A 1 238 ? -25.90716 -18.12084 16.53755  1.000 53.14006 ? 243  TYR   A OH   1 
ATOM   1665 N  N    . SER   A 1 239 ? -28.66910 -14.11718 13.39107  1.000 36.91966 ? 244  SER   A N    1 
ATOM   1666 C  CA   . SER   A 1 239 ? -30.04910 -14.12512 13.86505  1.000 41.21971 ? 244  SER   A CA   1 
ATOM   1667 C  C    . SER   A 1 239 ? -30.83509 -12.98719 13.23391  1.000 43.23895 ? 244  SER   A C    1 
ATOM   1668 O  O    . SER   A 1 239 ? -31.87108 -13.20226 12.59592  1.000 41.84194 ? 244  SER   A O    1 
ATOM   1669 C  CB   . SER   A 1 239 ? -30.08913 -14.02095 15.38903  1.000 42.16745 ? 244  SER   A CB   1 
ATOM   1670 O  OG   . SER   A 1 239 ? -29.74714 -15.25289 15.99618  1.000 51.78207 ? 244  SER   A OG   1 
ATOM   1671 N  N    . LYS   A 1 240 ? -30.34309 -11.75717 13.39578  1.000 39.68572 ? 245  LYS   A N    1 
ATOM   1672 C  CA   . LYS   A 1 240 ? -31.02007 -10.60824 12.81764  1.000 36.27544 ? 245  LYS   A CA   1 
ATOM   1673 C  C    . LYS   A 1 240 ? -30.84605 -10.52440 11.31764  1.000 39.47884 ? 245  LYS   A C    1 
ATOM   1674 O  O    . LYS   A 1 240 ? -31.49404 -9.68447  10.69353  1.000 39.77907 ? 245  LYS   A O    1 
ATOM   1675 C  CB   . LYS   A 1 240 ? -30.50808 -9.30817  13.44451  1.000 42.94426 ? 245  LYS   A CB   1 
ATOM   1676 C  CG   . LYS   A 1 240 ? -30.64610 -9.25400  14.96150  1.000 53.20899 ? 245  LYS   A CG   1 
ATOM   1677 C  CD   . LYS   A 1 240 ? -30.63011 -7.82194  15.47034  1.000 57.20754 ? 245  LYS   A CD   1 
ATOM   1678 C  CE   . LYS   A 1 240 ? -30.61613 -7.78078  16.99534  1.000 67.42483 ? 245  LYS   A CE   1 
ATOM   1679 N  NZ   . LYS   A 1 240 ? -30.19313 -6.44472  17.51020  1.000 55.60829 ? 245  LYS   A NZ   1 
ATOM   1680 N  N    . GLY   A 1 241 ? -29.97904 -11.34947 10.73774  1.000 41.28243 ? 246  GLY   A N    1 
ATOM   1681 C  CA   . GLY   A 1 241 ? -29.68602 -11.26563 9.31374   1.000 30.49129 ? 246  GLY   A CA   1 
ATOM   1682 C  C    . GLY   A 1 241 ? -29.10601 -9.93868  8.87260   1.000 36.43190 ? 246  GLY   A C    1 
ATOM   1683 O  O    . GLY   A 1 241 ? -29.41599 -9.46880  7.76954   1.000 43.34653 ? 246  GLY   A O    1 
ATOM   1684 N  N    . LYS   A 1 242 ? -28.25402 -9.32459  9.69954   1.000 37.47084 ? 247  LYS   A N    1 
ATOM   1685 C  CA   . LYS   A 1 242 ? -27.69901 -8.00162  9.42441   1.000 36.33911 ? 247  LYS   A CA   1 
ATOM   1686 C  C    . LYS   A 1 242 ? -26.18101 -8.07064  9.30744   1.000 36.41873 ? 247  LYS   A C    1 
ATOM   1687 O  O    . LYS   A 1 242 ? -25.51302 -8.67355  10.15352  1.000 28.68054 ? 247  LYS   A O    1 
ATOM   1688 C  CB   . LYS   A 1 242 ? -28.06902 -6.99750  10.52229  1.000 38.76158 ? 247  LYS   A CB   1 
ATOM   1689 C  CG   . LYS   A 1 242 ? -29.55202 -6.72248  10.64824  1.000 55.52699 ? 247  LYS   A CG   1 
ATOM   1690 C  CD   . LYS   A 1 242 ? -29.91601 -5.35354  10.08408  1.000 63.91643 ? 247  LYS   A CD   1 
ATOM   1691 C  CE   . LYS   A 1 242 ? -31.28302 -4.88948  10.58401  1.000 70.61259 ? 247  LYS   A CE   1 
ATOM   1692 N  NZ   . LYS   A 1 242 ? -31.44701 -3.40849  10.46084  1.000 75.15320 ? 247  LYS   A NZ   1 
ATOM   1693 N  N    . CYS   A 1 243 ? -25.64399 -7.42876  8.27638   1.000 36.74834 ? 248  CYS   A N    1 
ATOM   1694 C  CA   . CYS   A 1 243 ? -24.20499 -7.23277  8.16738   1.000 35.59228 ? 248  CYS   A CA   1 
ATOM   1695 C  C    . CYS   A 1 243 ? -23.78600 -6.07868  9.07326   1.000 33.74456 ? 248  CYS   A C    1 
ATOM   1696 O  O    . CYS   A 1 243 ? -24.30599 -4.96969  8.93613   1.000 36.58085 ? 248  CYS   A O    1 
ATOM   1697 C  CB   . CYS   A 1 243 ? -23.82396 -6.95494  6.71735   1.000 33.84261 ? 248  CYS   A CB   1 
ATOM   1698 S  SG   . CYS   A 1 243 ? -22.07096 -6.60496  6.52434   1.000 35.80110 ? 248  CYS   A SG   1 
ATOM   1699 N  N    . LEU   A 1 244 ? -22.85101 -6.33358  9.99430   1.000 30.86662 ? 249  LEU   A N    1 
ATOM   1700 C  CA   . LEU   A 1 244 ? -22.44403 -5.36147  11.01020  1.000 30.21999 ? 249  LEU   A CA   1 
ATOM   1701 C  C    . LEU   A 1 244 ? -21.10902 -4.68350  10.73115  1.000 37.41269 ? 249  LEU   A C    1 
ATOM   1702 O  O    . LEU   A 1 244 ? -20.90602 -3.54046  11.15302  1.000 34.34564 ? 249  LEU   A O    1 
ATOM   1703 C  CB   . LEU   A 1 244 ? -22.35205 -6.03432  12.38528  1.000 30.74326 ? 249  LEU   A CB   1 
ATOM   1704 C  CG   . LEU   A 1 244 ? -23.60206 -6.76326  12.87034  1.000 34.24065 ? 249  LEU   A CG   1 
ATOM   1705 C  CD1  . LEU   A 1 244 ? -23.26608 -7.68613  14.03144  1.000 34.98247 ? 249  LEU   A CD1  1 
ATOM   1706 C  CD2  . LEU   A 1 244 ? -24.67906 -5.77521  13.26821  1.000 40.36820 ? 249  LEU   A CD2  1 
ATOM   1707 N  N    . LYS   A 1 245 ? -20.17501 -5.36758  10.07724  1.000 27.27814 ? 250  LYS   A N    1 
ATOM   1708 C  CA   . LYS   A 1 245 ? -18.86400 -4.81062  9.78220   1.000 29.89874 ? 250  LYS   A CA   1 
ATOM   1709 C  C    . LYS   A 1 245 ? -18.40598 -5.35177  8.43726   1.000 28.90319 ? 250  LYS   A C    1 
ATOM   1710 O  O    . LYS   A 1 245 ? -18.71298 -6.49180  8.08238   1.000 27.10114 ? 250  LYS   A O    1 
ATOM   1711 C  CB   . LYS   A 1 245 ? -17.83002 -5.16750  10.85725  1.000 31.83662 ? 250  LYS   A CB   1 
ATOM   1712 C  CG   . LYS   A 1 245 ? -18.21704 -4.77734  12.27820  1.000 33.37135 ? 250  LYS   A CG   1 
ATOM   1713 C  CD   . LYS   A 1 245 ? -17.99404 -3.29831  12.54404  1.000 36.85947 ? 250  LYS   A CD   1 
ATOM   1714 C  CE   . LYS   A 1 245 ? -18.35106 -2.96015  13.99800  1.000 35.53151 ? 250  LYS   A CE   1 
ATOM   1715 N  NZ   . LYS   A 1 245 ? -18.00606 -1.54012  14.32285  1.000 36.74523 ? 250  LYS   A NZ   1 
ATOM   1716 N  N    . THR   A 1 246 ? -17.66597 -4.52485  7.69918   1.000 29.17414 ? 251  THR   A N    1 
ATOM   1717 C  CA   . THR   A 1 246 ? -17.06395 -4.91499  6.42924   1.000 30.15101 ? 251  THR   A CA   1 
ATOM   1718 C  C    . THR   A 1 246 ? -15.56895 -4.62199  6.47423   1.000 35.15182 ? 251  THR   A C    1 
ATOM   1719 O  O    . THR   A 1 246 ? -15.16595 -3.53695  6.90311   1.000 30.38318 ? 251  THR   A O    1 
ATOM   1720 C  CB   . THR   A 1 246 ? -17.73093 -4.17112  5.27014   1.000 31.75907 ? 251  THR   A CB   1 
ATOM   1721 O  OG1  . THR   A 1 246 ? -19.12593 -4.50812  5.23316   1.000 30.31127 ? 251  THR   A OG1  1 
ATOM   1722 C  CG2  . THR   A 1 246 ? -17.10391 -4.55427  3.95620   1.000 34.33351 ? 251  THR   A CG2  1 
ATOM   1723 N  N    . TYR   A 1 247 ? -14.74895 -5.58304  6.04335   1.000 28.76065 ? 252  TYR   A N    1 
ATOM   1724 C  CA   . TYR   A 1 247 ? -13.29395 -5.44705  6.05935   1.000 29.36751 ? 252  TYR   A CA   1 
ATOM   1725 C  C    . TYR   A 1 247 ? -12.75893 -5.59421  4.64238   1.000 27.41641 ? 252  TYR   A C    1 
ATOM   1726 O  O    . TYR   A 1 247 ? -13.06192 -6.57928  3.95648   1.000 26.27412 ? 252  TYR   A O    1 
ATOM   1727 C  CB   . TYR   A 1 247 ? -12.64897 -6.47995  6.99748   1.000 26.01042 ? 252  TYR   A CB   1 
ATOM   1728 C  CG   . TYR   A 1 247 ? -13.31199 -6.51680  8.34747   1.000 26.40243 ? 252  TYR   A CG   1 
ATOM   1729 C  CD1  . TYR   A 1 247 ? -12.90400 -5.66368  9.37338   1.000 25.46831 ? 252  TYR   A CD1  1 
ATOM   1730 C  CD2  . TYR   A 1 247 ? -14.35999 -7.38376  8.59455   1.000 25.23295 ? 252  TYR   A CD2  1 
ATOM   1731 C  CE1  . TYR   A 1 247 ? -13.53102 -5.69054  10.62338  1.000 24.91108 ? 252  TYR   A CE1  1 
ATOM   1732 C  CE2  . TYR   A 1 247 ? -14.99201 -7.41463  9.81955   1.000 29.15025 ? 252  TYR   A CE2  1 
ATOM   1733 C  CZ   . TYR   A 1 247 ? -14.57003 -6.56552  10.83346  1.000 32.30923 ? 252  TYR   A CZ   1 
ATOM   1734 O  OH   . TYR   A 1 247 ? -15.20705 -6.60438  12.05345  1.000 27.17192 ? 252  TYR   A OH   1 
ATOM   1735 N  N    . THR   A 1 248 ? -11.97791 -4.60826  4.19828   1.000 25.26829 ? 253  THR   A N    1 
ATOM   1736 C  CA   . THR   A 1 248 ? -11.44989 -4.60441  2.84129   1.000 26.71244 ? 253  THR   A CA   1 
ATOM   1737 C  C    . THR   A 1 248 ? -10.00089 -4.14841  2.86826   1.000 26.92338 ? 253  THR   A C    1 
ATOM   1738 O  O    . THR   A 1 248 ? -9.44691  -3.80330  3.92323   1.000 27.33615 ? 253  THR   A O    1 
ATOM   1739 C  CB   . THR   A 1 248 ? -12.25887 -3.69351  1.91018   1.000 29.48799 ? 253  THR   A CB   1 
ATOM   1740 O  OG1  . THR   A 1 248 ? -12.25288 -2.36045  2.44203   1.000 30.06567 ? 253  THR   A OG1  1 
ATOM   1741 C  CG2  . THR   A 1 248 ? -13.68487 -4.18052  1.80021   1.000 34.38038 ? 253  THR   A CG2  1 
ATOM   1742 N  N    . GLY   A 1 249 ? -9.39587  -4.11855  1.67827   1.000 28.50149 ? 254  GLY   A N    1 
ATOM   1743 C  CA   . GLY   A 1 249 ? -8.01187  -3.74757  1.49525   1.000 25.14707 ? 254  GLY   A CA   1 
ATOM   1744 C  C    . GLY   A 1 249 ? -7.12187  -4.88862  1.04539   1.000 26.70359 ? 254  GLY   A C    1 
ATOM   1745 O  O    . GLY   A 1 249 ? -6.03586  -4.63469  0.50538   1.000 29.08616 ? 254  GLY   A O    1 
ATOM   1746 N  N    . HIS   A 1 250 ? -7.54887  -6.13660  1.24652   1.000 23.93947 ? 255  HIS   A N    1 
ATOM   1747 C  CA   . HIS   A 1 250 ? -6.76387  -7.28265  0.81866   1.000 26.84879 ? 255  HIS   A CA   1 
ATOM   1748 C  C    . HIS   A 1 250 ? -7.21685  -7.73580  -0.56930  1.000 27.62495 ? 255  HIS   A C    1 
ATOM   1749 O  O    . HIS   A 1 250 ? -8.12984  -7.16987  -1.17037  1.000 28.19365 ? 255  HIS   A O    1 
ATOM   1750 C  CB   . HIS   A 1 250 ? -6.89789  -8.41854  1.82378   1.000 20.75148 ? 255  HIS   A CB   1 
ATOM   1751 C  CG   . HIS   A 1 250 ? -8.29989  -8.91052  1.96482   1.000 27.26427 ? 255  HIS   A CG   1 
ATOM   1752 N  ND1  . HIS   A 1 250 ? -9.35790  -8.06449  2.20771   1.000 28.44546 ? 255  HIS   A ND1  1 
ATOM   1753 C  CD2  . HIS   A 1 250 ? -8.82190  -10.15752 1.89595   1.000 26.21068 ? 255  HIS   A CD2  1 
ATOM   1754 C  CE1  . HIS   A 1 250 ? -10.47490 -8.76648  2.28277   1.000 30.11835 ? 255  HIS   A CE1  1 
ATOM   1755 N  NE2  . HIS   A 1 250 ? -10.17690 -10.03950 2.09591   1.000 28.54974 ? 255  HIS   A NE2  1 
ATOM   1756 N  N    . LYS   A 1 251 ? -6.59585  -8.78686  -1.08117  1.000 21.78292 ? 256  LYS   A N    1 
ATOM   1757 C  CA   . LYS   A 1 251 ? -6.92583  -9.31301  -2.39712  1.000 23.78829 ? 256  LYS   A CA   1 
ATOM   1758 C  C    . LYS   A 1 251 ? -7.51784  -10.70398 -2.21297  1.000 25.92082 ? 256  LYS   A C    1 
ATOM   1759 O  O    . LYS   A 1 251 ? -6.86585  -11.58892 -1.64986  1.000 19.96878 ? 256  LYS   A O    1 
ATOM   1760 C  CB   . LYS   A 1 251 ? -5.68281  -9.35711  -3.29709  1.000 25.48380 ? 256  LYS   A CB   1 
ATOM   1761 C  CG   . LYS   A 1 251 ? -6.02679  -9.32327  -4.77610  1.000 38.93652 ? 256  LYS   A CG   1 
ATOM   1762 C  CD   . LYS   A 1 251 ? -5.19378  -10.30237 -5.60898  1.000 49.47996 ? 256  LYS   A CD   1 
ATOM   1763 C  CE   . LYS   A 1 251 ? -4.14076  -9.58546  -6.45804  1.000 52.41078 ? 256  LYS   A CE   1 
ATOM   1764 N  NZ   . LYS   A 1 251 ? -3.38075  -10.54356 -7.31792  1.000 60.37238 ? 256  LYS   A NZ   1 
ATOM   1765 N  N    . ASN   A 1 252 ? -8.75283  -10.90303 -2.66797  1.000 20.62354 ? 257  ASN   A N    1 
ATOM   1766 C  CA   . ASN   A 1 252 ? -9.34384  -12.23001 -2.54583  1.000 21.99161 ? 257  ASN   A CA   1 
ATOM   1767 C  C    . ASN   A 1 252 ? -10.43182 -12.36513 -3.61384  1.000 22.69709 ? 257  ASN   A C    1 
ATOM   1768 O  O    . ASN   A 1 252 ? -11.59382 -12.03510 -3.37089  1.000 24.12528 ? 257  ASN   A O    1 
ATOM   1769 C  CB   . ASN   A 1 252 ? -9.89786  -12.46586 -1.15682  1.000 22.60993 ? 257  ASN   A CB   1 
ATOM   1770 C  CG   . ASN   A 1 252 ? -10.31187 -13.90383 -0.94366  1.000 20.97851 ? 257  ASN   A CG   1 
ATOM   1771 O  OD1  . ASN   A 1 252 ? -9.87486  -14.81191 -1.66956  1.000 26.09194 ? 257  ASN   A OD1  1 
ATOM   1772 N  ND2  . ASN   A 1 252 ? -11.15288 -14.12372 0.05135   1.000 20.40646 ? 257  ASN   A ND2  1 
ATOM   1773 N  N    . GLU   A 1 253 ? -10.03780 -12.85926 -4.78377  1.000 19.90349 ? 258  GLU   A N    1 
ATOM   1774 C  CA   . GLU   A 1 253 ? -10.98379 -13.09237 -5.86476  1.000 20.30443 ? 258  GLU   A CA   1 
ATOM   1775 C  C    . GLU   A 1 253 ? -10.94078 -14.50643 -6.41061  1.000 25.23114 ? 258  GLU   A C    1 
ATOM   1776 O  O    . GLU   A 1 253 ? -11.75977 -14.83953 -7.27358  1.000 23.72101 ? 258  GLU   A O    1 
ATOM   1777 C  CB   . GLU   A 1 253 ? -10.72276 -12.11150 -7.01387  1.000 25.75306 ? 258  GLU   A CB   1 
ATOM   1778 C  CG   . GLU   A 1 253 ? -11.17276 -10.70147 -6.71003  1.000 30.89998 ? 258  GLU   A CG   1 
ATOM   1779 C  CD   . GLU   A 1 253 ? -10.79274 -9.71659  -7.81713  1.000 39.80636 ? 258  GLU   A CD   1 
ATOM   1780 O  OE1  . GLU   A 1 253 ? -10.07273 -10.13470 -8.75508  1.000 34.54197 ? 258  GLU   A OE1  1 
ATOM   1781 O  OE2  . GLU   A 1 253 ? -11.19774 -8.53358  -7.73627  1.000 33.13574 ? 258  GLU   A OE2  1 
ATOM   1782 N  N    . LYS   A 1 254 ? -10.01979 -15.33439 -5.96050  1.000 20.11493 ? 259  LYS   A N    1 
ATOM   1783 C  CA   . LYS   A 1 254 ? -9.85279  -16.62546 -6.60736  1.000 22.33371 ? 259  LYS   A CA   1 
ATOM   1784 C  C    . LYS   A 1 254 ? -9.84981  -17.79835 -5.63623  1.000 26.79840 ? 259  LYS   A C    1 
ATOM   1785 O  O    . LYS   A 1 254 ? -10.48381 -18.82038 -5.92312  1.000 24.91702 ? 259  LYS   A O    1 
ATOM   1786 C  CB   . LYS   A 1 254 ? -8.53677  -16.61356 -7.43234  1.000 25.78143 ? 259  LYS   A CB   1 
ATOM   1787 C  CG   . LYS   A 1 254 ? -8.20977  -17.95063 -8.13518  1.000 33.77589 ? 259  LYS   A CG   1 
ATOM   1788 C  CD   . LYS   A 1 254 ? -6.95375  -17.83674 -9.03718  1.000 39.70503 ? 259  LYS   A CD   1 
ATOM   1789 C  CE   . LYS   A 1 254 ? -6.43175  -19.19879 -9.52702  1.000 45.24114 ? 259  LYS   A CE   1 
ATOM   1790 N  NZ   . LYS   A 1 254 ? -7.28874  -19.79891 -10.57496 1.000 50.02310 ? 259  LYS   A NZ   1 
ATOM   1791 N  N    . TYR   A 1 255 ? -9.14882  -17.68723 -4.50423  1.000 21.82427 ? 260  TYR   A N    1 
ATOM   1792 C  CA   . TYR   A 1 255 ? -8.93584  -18.80613 -3.59210  1.000 17.19773 ? 260  TYR   A CA   1 
ATOM   1793 C  C    . TYR   A 1 255 ? -9.82386  -18.69399 -2.35913  1.000 21.51583 ? 260  TYR   A C    1 
ATOM   1794 O  O    . TYR   A 1 255 ? -10.19587 -17.59994 -1.93125  1.000 18.74370 ? 260  TYR   A O    1 
ATOM   1795 C  CB   . TYR   A 1 255 ? -7.46585  -18.88809 -3.16307  1.000 22.00312 ? 260  TYR   A CB   1 
ATOM   1796 C  CG   . TYR   A 1 255 ? -6.57883  -19.33122 -4.30601  1.000 20.20625 ? 260  TYR   A CG   1 
ATOM   1797 C  CD1  . TYR   A 1 255 ? -6.48783  -20.67126 -4.64286  1.000 23.78492 ? 260  TYR   A CD1  1 
ATOM   1798 C  CD2  . TYR   A 1 255 ? -5.86882  -18.41430 -5.06310  1.000 25.83870 ? 260  TYR   A CD2  1 
ATOM   1799 C  CE1  . TYR   A 1 255 ? -5.69682  -21.09437 -5.69480  1.000 30.51055 ? 260  TYR   A CE1  1 
ATOM   1800 C  CE2  . TYR   A 1 255 ? -5.06480  -18.83042 -6.12504  1.000 25.08258 ? 260  TYR   A CE2  1 
ATOM   1801 C  CZ   . TYR   A 1 255 ? -4.99080  -20.17246 -6.42889  1.000 27.72060 ? 260  TYR   A CZ   1 
ATOM   1802 O  OH   . TYR   A 1 255 ? -4.21479  -20.61358 -7.47783  1.000 38.50492 ? 260  TYR   A OH   1 
ATOM   1803 N  N    . CYS   A 1 256 ? -10.15488 -19.84593 -1.77801  1.000 20.12683 ? 261  CYS   A N    1 
ATOM   1804 C  CA   . CYS   A 1 256 ? -10.96290 -19.86079 -0.56302  1.000 19.39666 ? 261  CYS   A CA   1 
ATOM   1805 C  C    . CYS   A 1 256 ? -10.00991 -19.73666 0.61499   1.000 18.35807 ? 261  CYS   A C    1 
ATOM   1806 O  O    . CYS   A 1 256 ? -9.47493  -20.72761 1.12910   1.000 19.76485 ? 261  CYS   A O    1 
ATOM   1807 C  CB   . CYS   A 1 256 ? -11.82490 -21.11078 -0.50089  1.000 19.81263 ? 261  CYS   A CB   1 
ATOM   1808 S  SG   . CYS   A 1 256 ? -13.09788 -20.99791 -1.74692  1.000 21.65075 ? 261  CYS   A SG   1 
ATOM   1809 N  N    . ILE   A 1 257 ? -9.83692  -18.49861 1.06385   1.000 21.79136 ? 262  ILE   A N    1 
ATOM   1810 C  CA   . ILE   A 1 257 ? -8.88493  -18.14750 2.10983   1.000 17.12083 ? 262  ILE   A CA   1 
ATOM   1811 C  C    . ILE   A 1 257 ? -9.56895  -18.21435 3.46982   1.000 21.43326 ? 262  ILE   A C    1 
ATOM   1812 O  O    . ILE   A 1 257 ? -10.63795 -17.61932 3.67574   1.000 25.39466 ? 262  ILE   A O    1 
ATOM   1813 C  CB   . ILE   A 1 257 ? -8.31692  -16.74253 1.85768   1.000 19.81306 ? 262  ILE   A CB   1 
ATOM   1814 C  CG1  . ILE   A 1 257 ? -7.59890  -16.70968 0.49169   1.000 20.70830 ? 262  ILE   A CG1  1 
ATOM   1815 C  CG2  . ILE   A 1 257 ? -7.40394  -16.32241 3.00065   1.000 20.41156 ? 262  ILE   A CG2  1 
ATOM   1816 C  CD1  . ILE   A 1 257 ? -6.90989  -15.37372 0.18955   1.000 20.82788 ? 262  ILE   A CD1  1 
ATOM   1817 N  N    . PHE   A 1 258 ? -8.93197  -18.90125 4.40791   1.000 18.57911 ? 263  PHE   A N    1 
ATOM   1818 C  CA   . PHE   A 1 258 ? -9.43599  -19.04009 5.76792   1.000 18.92862 ? 263  PHE   A CA   1 
ATOM   1819 C  C    . PHE   A 1 258 ? -9.15800  -17.77301 6.57078   1.000 29.19125 ? 263  PHE   A C    1 
ATOM   1820 O  O    . PHE   A 1 258 ? -8.06200  -17.20902 6.49474   1.000 31.77318 ? 263  PHE   A O    1 
ATOM   1821 C  CB   . PHE   A 1 258 ? -8.74801  -20.22902 6.43306   1.000 21.94407 ? 263  PHE   A CB   1 
ATOM   1822 C  CG   . PHE   A 1 258 ? -9.53703  -20.86390 7.53312   1.000 21.87880 ? 263  PHE   A CG   1 
ATOM   1823 C  CD1  . PHE   A 1 258 ? -9.46805  -20.37976 8.82006   1.000 22.03486 ? 263  PHE   A CD1  1 
ATOM   1824 C  CD2  . PHE   A 1 258 ? -10.30003 -21.98892 7.28323   1.000 21.65156 ? 263  PHE   A CD2  1 
ATOM   1825 C  CE1  . PHE   A 1 258 ? -10.16907 -20.99564 9.84812   1.000 21.60637 ? 263  PHE   A CE1  1 
ATOM   1826 C  CE2  . PHE   A 1 258 ? -11.00105 -22.61281 8.30129   1.000 22.02912 ? 263  PHE   A CE2  1 
ATOM   1827 C  CZ   . PHE   A 1 258 ? -10.94507 -22.09967 9.58523   1.000 21.60794 ? 263  PHE   A CZ   1 
ATOM   1828 N  N    . ALA   A 1 259 ? -10.13401 -17.33891 7.37072   1.000 23.11351 ? 264  ALA   A N    1 
ATOM   1829 C  CA   . ALA   A 1 259 ? -9.97002  -16.15882 8.21359   1.000 26.41395 ? 264  ALA   A CA   1 
ATOM   1830 C  C    . ALA   A 1 259 ? -10.30105 -16.50766 9.66362   1.000 22.50564 ? 264  ALA   A C    1 
ATOM   1831 O  O    . ALA   A 1 259 ? -10.77805 -17.60463 9.96774   1.000 22.68906 ? 264  ALA   A O    1 
ATOM   1832 C  CB   . ALA   A 1 259 ? -10.83601 -14.99487 7.71045   1.000 20.14512 ? 264  ALA   A CB   1 
ATOM   1833 N  N    . ASN   A 1 260 ? -10.03906 -15.56756 10.57552  1.000 19.58870 ? 265  ASN   A N    1 
ATOM   1834 C  CA   . ASN   A 1 260 ? -10.14108 -15.87540 11.99856  1.000 23.45582 ? 265  ASN   A CA   1 
ATOM   1835 C  C    . ASN   A 1 260 ? -10.48909 -14.64031 12.80141  1.000 22.09718 ? 265  ASN   A C    1 
ATOM   1836 O  O    . ASN   A 1 260 ? -10.20008 -13.51536 12.38830  1.000 23.60706 ? 265  ASN   A O    1 
ATOM   1837 C  CB   . ASN   A 1 260 ? -8.82609  -16.43335 12.57264  1.000 22.38868 ? 265  ASN   A CB   1 
ATOM   1838 C  CG   . ASN   A 1 260 ? -8.38109  -17.69242 11.87979  1.000 28.52254 ? 265  ASN   A CG   1 
ATOM   1839 O  OD1  . ASN   A 1 260 ? -8.83209  -18.79338 12.21590  1.000 32.08381 ? 265  ASN   A OD1  1 
ATOM   1840 N  ND2  . ASN   A 1 260 ? -7.49907  -17.54354 10.89778  1.000 28.76613 ? 265  ASN   A ND2  1 
ATOM   1841 N  N    . PHE   A 1 261 ? -11.10011 -14.87518 13.96643  1.000 23.58446 ? 266  PHE   A N    1 
ATOM   1842 C  CA   . PHE   A 1 261 ? -11.14012 -13.89606 15.04032  1.000 22.72760 ? 266  PHE   A CA   1 
ATOM   1843 C  C    . PHE   A 1 261 ? -9.89214  -14.09898 15.88636  1.000 25.86793 ? 266  PHE   A C    1 
ATOM   1844 O  O    . PHE   A 1 261 ? -9.61015  -15.21993 16.31249  1.000 26.60226 ? 266  PHE   A O    1 
ATOM   1845 C  CB   . PHE   A 1 261 ? -12.38414 -14.06796 15.92032  1.000 23.58450 ? 266  PHE   A CB   1 
ATOM   1846 C  CG   . PHE   A 1 261 ? -13.68012 -13.85404 15.19828  1.000 31.58787 ? 266  PHE   A CG   1 
ATOM   1847 C  CD1  . PHE   A 1 261 ? -14.25012 -14.88012 14.44838  1.000 23.84127 ? 266  PHE   A CD1  1 
ATOM   1848 C  CD2  . PHE   A 1 261 ? -14.34012 -12.63103 15.27813  1.000 26.62145 ? 266  PHE   A CD2  1 
ATOM   1849 C  CE1  . PHE   A 1 261 ? -15.44010 -14.69219 13.78134  1.000 24.09369 ? 266  PHE   A CE1  1 
ATOM   1850 C  CE2  . PHE   A 1 261 ? -15.54211 -12.43610 14.60709  1.000 30.60526 ? 266  PHE   A CE2  1 
ATOM   1851 C  CZ   . PHE   A 1 261 ? -16.09310 -13.47018 13.85620  1.000 27.91888 ? 266  PHE   A CZ   1 
ATOM   1852 N  N    . SER   A 1 262 ? -9.14814  -13.02795 16.12826  1.000 24.39884 ? 267  SER   A N    1 
ATOM   1853 C  CA   . SER   A 1 262 ? -8.05515  -13.06785 17.09028  1.000 24.79371 ? 267  SER   A CA   1 
ATOM   1854 C  C    . SER   A 1 262 ? -8.53317  -12.43570 18.39520  1.000 27.53022 ? 267  SER   A C    1 
ATOM   1855 O  O    . SER   A 1 262 ? -8.94117  -11.26870 18.41007  1.000 25.43987 ? 267  SER   A O    1 
ATOM   1856 C  CB   . SER   A 1 262 ? -6.82714  -12.34091 16.55822  1.000 23.31435 ? 267  SER   A CB   1 
ATOM   1857 O  OG   . SER   A 1 262 ? -5.78716  -12.43181 17.50925  1.000 27.40172 ? 267  SER   A OG   1 
ATOM   1858 N  N    . VAL   A 1 263 ? -8.48819  -13.19858 19.48329  1.000 23.18037 ? 268  VAL   A N    1 
ATOM   1859 C  CA   . VAL   A 1 263 ? -9.14521  -12.75245 20.70623  1.000 30.22367 ? 268  VAL   A CA   1 
ATOM   1860 C  C    . VAL   A 1 263 ? -8.22523  -12.81931 21.92425  1.000 34.89731 ? 268  VAL   A C    1 
ATOM   1861 O  O    . VAL   A 1 263 ? -8.60524  -12.37319 23.01419  1.000 39.85320 ? 268  VAL   A O    1 
ATOM   1862 C  CB   . VAL   A 1 263 ? -10.43521 -13.56341 20.95130  1.000 28.15659 ? 268  VAL   A CB   1 
ATOM   1863 C  CG1  . VAL   A 1 263 ? -11.43120 -13.33354 19.81626  1.000 34.26624 ? 268  VAL   A CG1  1 
ATOM   1864 C  CG2  . VAL   A 1 263 ? -10.12022 -15.04240 21.08447  1.000 32.09332 ? 268  VAL   A CG2  1 
ATOM   1865 N  N    . THR   A 1 264 ? -7.01623  -13.36934 21.76533  1.000 29.39401 ? 269  THR   A N    1 
ATOM   1866 C  CA   . THR   A 1 264 ? -6.13625  -13.51021 22.92936  1.000 27.29536 ? 269  THR   A CA   1 
ATOM   1867 C  C    . THR   A 1 264 ? -5.62425  -12.16016 23.41722  1.000 32.27752 ? 269  THR   A C    1 
ATOM   1868 O  O    . THR   A 1 264 ? -5.38727  -11.99303 24.61920  1.000 34.59809 ? 269  THR   A O    1 
ATOM   1869 C  CB   . THR   A 1 264 ? -4.95224  -14.43625 22.61948  1.000 26.65542 ? 269  THR   A CB   1 
ATOM   1870 O  OG1  . THR   A 1 264 ? -4.29522  -13.99138 21.42444  1.000 28.03689 ? 269  THR   A OG1  1 
ATOM   1871 C  CG2  . THR   A 1 264 ? -5.42225  -15.87127 22.43163  1.000 24.81220 ? 269  THR   A CG2  1 
ATOM   1872 N  N    . GLY   A 1 265 ? -5.42323  -11.20326 22.51412  1.000 32.53772 ? 270  GLY   A N    1 
ATOM   1873 C  CA   . GLY   A 1 265 ? -4.95723  -9.87222  22.87798  1.000 32.59019 ? 270  GLY   A CA   1 
ATOM   1874 C  C    . GLY   A 1 265 ? -5.96222  -8.81026  22.49084  1.000 26.81135 ? 270  GLY   A C    1 
ATOM   1875 O  O    . GLY   A 1 265 ? -7.09323  -8.82520  22.98083  1.000 30.29332 ? 270  GLY   A O    1 
ATOM   1876 N  N    . GLY   A 1 266 ? -5.58020  -7.88436  21.61675  1.000 29.46260 ? 271  GLY   A N    1 
ATOM   1877 C  CA   . GLY   A 1 266 ? -6.56919  -7.03042  20.98364  1.000 30.63650 ? 271  GLY   A CA   1 
ATOM   1878 C  C    . GLY   A 1 266 ? -7.54318  -7.83551  20.13971  1.000 33.48005 ? 271  GLY   A C    1 
ATOM   1879 O  O    . GLY   A 1 266 ? -7.28118  -8.97756  19.75184  1.000 30.38056 ? 271  GLY   A O    1 
ATOM   1880 N  N    . LYS   A 1 267 ? -8.69517  -7.23654  19.85263  1.000 25.56649 ? 272  LYS   A N    1 
ATOM   1881 C  CA   . LYS   A 1 267 ? -9.74716  -7.93462  19.10669  1.000 29.83794 ? 272  LYS   A CA   1 
ATOM   1882 C  C    . LYS   A 1 267 ? -9.53414  -7.66678  17.62366  1.000 26.47701 ? 272  LYS   A C    1 
ATOM   1883 O  O    . LYS   A 1 267 ? -9.86313  -6.58584  17.12454  1.000 27.19039 ? 272  LYS   A O    1 
ATOM   1884 C  CB   . LYS   A 1 267 ? -11.12917 -7.48756  19.57361  1.000 32.16238 ? 272  LYS   A CB   1 
ATOM   1885 C  CG   . LYS   A 1 267 ? -11.45119 -7.92341  20.98966  1.000 29.54169 ? 272  LYS   A CG   1 
ATOM   1886 C  CD   . LYS   A 1 267 ? -11.26420 -9.42339  21.11583  1.000 35.61321 ? 272  LYS   A CD   1 
ATOM   1887 C  CE   . LYS   A 1 267 ? -11.70223 -9.95024  22.46788  1.000 42.91373 ? 272  LYS   A CE   1 
ATOM   1888 N  NZ   . LYS   A 1 267 ? -10.65324 -9.74013  23.48587  1.000 43.51708 ? 272  LYS   A NZ   1 
ATOM   1889 N  N    . TRP   A 1 268 ? -8.95613  -8.64287  16.91178  1.000 24.56184 ? 273  TRP   A N    1 
ATOM   1890 C  CA   . TRP   A 1 268 ? -8.62611  -8.46702  15.50476  1.000 22.79746 ? 273  TRP   A CA   1 
ATOM   1891 C  C    . TRP   A 1 268 ? -9.40210  -9.44312  14.63686  1.000 25.60808 ? 273  TRP   A C    1 
ATOM   1892 O  O    . TRP   A 1 268 ? -9.92211  -10.46306 15.10496  1.000 24.09179 ? 273  TRP   A O    1 
ATOM   1893 C  CB   . TRP   A 1 268 ? -7.12710  -8.68006  15.20981  1.000 27.51875 ? 273  TRP   A CB   1 
ATOM   1894 C  CG   . TRP   A 1 268 ? -6.19612  -8.18895  16.25377  1.000 32.02071 ? 273  TRP   A CG   1 
ATOM   1895 C  CD1  . TRP   A 1 268 ? -5.31413  -8.94287  16.98687  1.000 26.54872 ? 273  TRP   A CD1  1 
ATOM   1896 C  CD2  . TRP   A 1 268 ? -6.03712  -6.83490  16.69862  1.000 26.13914 ? 273  TRP   A CD2  1 
ATOM   1897 N  NE1  . TRP   A 1 268 ? -4.62315  -8.13878  17.85679  1.000 25.06092 ? 273  TRP   A NE1  1 
ATOM   1898 C  CE2  . TRP   A 1 268 ? -5.04614  -6.84179  17.70364  1.000 25.86008 ? 273  TRP   A CE2  1 
ATOM   1899 C  CE3  . TRP   A 1 268 ? -6.63811  -5.62194  16.35048  1.000 28.46230 ? 273  TRP   A CE3  1 
ATOM   1900 C  CZ2  . TRP   A 1 268 ? -4.64114  -5.67772  18.36452  1.000 29.22356 ? 273  TRP   A CZ2  1 
ATOM   1901 C  CZ3  . TRP   A 1 268 ? -6.22612  -4.46287  16.99936  1.000 30.62312 ? 273  TRP   A CZ3  1 
ATOM   1902 C  CH2  . TRP   A 1 268 ? -5.23913  -4.50376  18.00038  1.000 31.72646 ? 273  TRP   A CH2  1 
ATOM   1903 N  N    . ILE   A 1 269 ? -9.44508  -9.11126  13.34882  1.000 24.64749 ? 274  ILE   A N    1 
ATOM   1904 C  CA   . ILE   A 1 269 ? -9.78906  -10.03937 12.28392  1.000 26.39742 ? 274  ILE   A CA   1 
ATOM   1905 C  C    . ILE   A 1 269 ? -8.50905  -10.33046 11.50597  1.000 21.61381 ? 274  ILE   A C    1 
ATOM   1906 O  O    . ILE   A 1 269 ? -7.76204  -9.40550  11.16588  1.000 24.69180 ? 274  ILE   A O    1 
ATOM   1907 C  CB   . ILE   A 1 269 ? -10.88405 -9.45847  11.36884  1.000 24.22969 ? 274  ILE   A CB   1 
ATOM   1908 C  CG1  . ILE   A 1 269 ? -12.17606 -9.19938  12.16879  1.000 24.57007 ? 274  ILE   A CG1  1 
ATOM   1909 C  CG2  . ILE   A 1 269 ? -11.13703 -10.38660 10.20293  1.000 20.85835 ? 274  ILE   A CG2  1 
ATOM   1910 C  CD1  . ILE   A 1 269 ? -12.82807 -10.44632 12.71091  1.000 22.97820 ? 274  ILE   A CD1  1 
ATOM   1911 N  N    . VAL   A 1 270 ? -8.25805  -11.60650 11.22012  1.000 25.43792 ? 275  VAL   A N    1 
ATOM   1912 C  CA   . VAL   A 1 270 ? -7.04004  -12.04958 10.54218  1.000 21.24101 ? 275  VAL   A CA   1 
ATOM   1913 C  C    . VAL   A 1 270 ? -7.41303  -12.83671 9.29426   1.000 22.23343 ? 275  VAL   A C    1 
ATOM   1914 O  O    . VAL   A 1 270 ? -8.23803  -13.75570 9.35335   1.000 25.44752 ? 275  VAL   A O    1 
ATOM   1915 C  CB   . VAL   A 1 270 ? -6.17306  -12.92648 11.46129  1.000 23.56635 ? 275  VAL   A CB   1 
ATOM   1916 C  CG1  . VAL   A 1 270 ? -4.96305  -13.43257 10.71037  1.000 23.37826 ? 275  VAL   A CG1  1 
ATOM   1917 C  CG2  . VAL   A 1 270 ? -5.77108  -12.15434 12.68422  1.000 19.77362 ? 275  VAL   A CG2  1 
ATOM   1918 N  N    . SER   A 1 271 ? -6.75801  -12.52384 8.17824   1.000 22.91995 ? 276  SER   A N    1 
ATOM   1919 C  CA   . SER   A 1 271 ? -6.98499  -13.29497 6.97232   1.000 19.47326 ? 276  SER   A CA   1 
ATOM   1920 C  C    . SER   A 1 271 ? -5.74398  -13.26207 6.09334   1.000 20.35599 ? 276  SER   A C    1 
ATOM   1921 O  O    . SER   A 1 271 ? -4.99397  -12.28308 6.08624   1.000 24.91109 ? 276  SER   A O    1 
ATOM   1922 C  CB   . SER   A 1 271 ? -8.20398  -12.76005 6.19924   1.000 22.59061 ? 276  SER   A CB   1 
ATOM   1923 O  OG   . SER   A 1 271 ? -8.32596  -13.37919 4.92431   1.000 23.61881 ? 276  SER   A OG   1 
ATOM   1924 N  N    . GLY   A 1 272 ? -5.54097  -14.34516 5.34946   1.000 23.07883 ? 277  GLY   A N    1 
ATOM   1925 C  CA   . GLY   A 1 272 ? -4.61295  -14.33728 4.24047   1.000 20.52382 ? 277  GLY   A CA   1 
ATOM   1926 C  C    . GLY   A 1 272 ? -5.14193  -13.50141 3.08337   1.000 17.89130 ? 277  GLY   A C    1 
ATOM   1927 O  O    . GLY   A 1 272 ? -6.23593  -12.93840 3.10929   1.000 20.77567 ? 277  GLY   A O    1 
ATOM   1928 N  N    . SER   A 1 273 ? -4.33991  -13.45553 2.02538   1.000 20.89075 ? 278  SER   A N    1 
ATOM   1929 C  CA   . SER   A 1 273 ? -4.57989  -12.54165 0.92328   1.000 20.37361 ? 278  SER   A CA   1 
ATOM   1930 C  C    . SER   A 1 273 ? -3.82387  -13.04978 -0.28965  1.000 22.34135 ? 278  SER   A C    1 
ATOM   1931 O  O    . SER   A 1 273 ? -2.77088  -13.68877 -0.15657  1.000 22.30156 ? 278  SER   A O    1 
ATOM   1932 C  CB   . SER   A 1 273 ? -4.13189  -11.11261 1.26713   1.000 21.64623 ? 278  SER   A CB   1 
ATOM   1933 O  OG   . SER   A 1 273 ? -4.38487  -10.23873 0.17503   1.000 25.81866 ? 278  SER   A OG   1 
ATOM   1934 N  N    . GLU   A 1 274 ? -4.34585  -12.72891 -1.47170  1.000 21.00564 ? 279  GLU   A N    1 
ATOM   1935 C  CA   . GLU   A 1 274 ? -3.71684  -13.18005 -2.70464  1.000 18.66658 ? 279  GLU   A CA   1 
ATOM   1936 C  C    . GLU   A 1 274 ? -2.56683  -12.28610 -3.14872  1.000 22.66069 ? 279  GLU   A C    1 
ATOM   1937 O  O    . GLU   A 1 274 ? -1.93881  -12.57922 -4.17368  1.000 22.15489 ? 279  GLU   A O    1 
ATOM   1938 C  CB   . GLU   A 1 274 ? -4.76682  -13.30717 -3.80864  1.000 21.21565 ? 279  GLU   A CB   1 
ATOM   1939 C  CG   . GLU   A 1 274 ? -5.72583  -14.49214 -3.56153  1.000 23.42615 ? 279  GLU   A CG   1 
ATOM   1940 C  CD   . GLU   A 1 274 ? -7.07882  -14.34721 -4.26056  1.000 26.34160 ? 279  GLU   A CD   1 
ATOM   1941 O  OE1  . GLU   A 1 274 ? -7.25380  -13.40030 -5.05867  1.000 24.00339 ? 279  GLU   A OE1  1 
ATOM   1942 O  OE2  . GLU   A 1 274 ? -7.96182  -15.19118 -4.00848  1.000 20.09664 ? 279  GLU   A OE2  1 
ATOM   1943 N  N    . ASP   A 1 275 ? -2.27683  -11.21003 -2.41683  1.000 23.60082 ? 280  ASP   A N    1 
ATOM   1944 C  CA   . ASP   A 1 275 ? -1.02483  -10.47905 -2.58189  1.000 24.59294 ? 280  ASP   A CA   1 
ATOM   1945 C  C    . ASP   A 1 275 ? 0.07215   -10.99095 -1.63282  1.000 24.38136 ? 280  ASP   A C    1 
ATOM   1946 O  O    . ASP   A 1 275 ? 1.07315   -10.30193 -1.42388  1.000 24.01870 ? 280  ASP   A O    1 
ATOM   1947 C  CB   . ASP   A 1 275 ? -1.25783  -8.96803  -2.40206  1.000 19.06561 ? 280  ASP   A CB   1 
ATOM   1948 C  CG   . ASP   A 1 275 ? -1.75085  -8.61087  -1.02911  1.000 24.84010 ? 280  ASP   A CG   1 
ATOM   1949 O  OD1  . ASP   A 1 275 ? -1.89786  -9.54278  -0.20801  1.000 25.43096 ? 280  ASP   A OD1  1 
ATOM   1950 O  OD2  . ASP   A 1 275 ? -2.00585  -7.40784  -0.76025  1.000 26.93737 ? 280  ASP   A OD2  1 
ATOM   1951 N  N    . ASN   A 1 276 ? -0.10286  -12.18588 -1.06169  1.000 24.92148 ? 281  ASN   A N    1 
ATOM   1952 C  CA   . ASN   A 1 276 ? 0.90013   -12.90080 -0.27560  1.000 23.55122 ? 281  ASN   A CA   1 
ATOM   1953 C  C    . ASN   A 1 276 ? 1.12411   -12.31565 1.11134   1.000 22.38405 ? 281  ASN   A C    1 
ATOM   1954 O  O    . ASN   A 1 276 ? 2.12709   -12.65158 1.75840   1.000 25.31279 ? 281  ASN   A O    1 
ATOM   1955 C  CB   . ASN   A 1 276 ? 2.26214   -12.98788 -0.97656  1.000 20.69101 ? 281  ASN   A CB   1 
ATOM   1956 C  CG   . ASN   A 1 276 ? 2.15516   -13.41704 -2.43252  1.000 26.71585 ? 281  ASN   A CG   1 
ATOM   1957 O  OD1  . ASN   A 1 276 ? 1.17216   -14.03309 -2.85747  1.000 23.41782 ? 281  ASN   A OD1  1 
ATOM   1958 N  ND2  . ASN   A 1 276 ? 3.18817   -13.09913 -3.20554  1.000 23.72797 ? 281  ASN   A ND2  1 
ATOM   1959 N  N    . LEU   A 1 277 ? 0.21310   -11.49259 1.61724   1.000 23.18776 ? 282  LEU   A N    1 
ATOM   1960 C  CA   . LEU   A 1 277 ? 0.33508   -10.93544 2.95518   1.000 24.01620 ? 282  LEU   A CA   1 
ATOM   1961 C  C    . LEU   A 1 277 ? -0.71594  -11.52833 3.88923   1.000 23.25153 ? 282  LEU   A C    1 
ATOM   1962 O  O    . LEU   A 1 277 ? -1.77293  -12.00138 3.45526   1.000 22.26350 ? 282  LEU   A O    1 
ATOM   1963 C  CB   . LEU   A 1 277 ? 0.18209   -9.40944  2.92201   1.000 23.73651 ? 282  LEU   A CB   1 
ATOM   1964 C  CG   . LEU   A 1 277 ? 1.02611   -8.63556  1.90693   1.000 26.32171 ? 282  LEU   A CG   1 
ATOM   1965 C  CD1  . LEU   A 1 277 ? 0.60411   -7.17256  1.91577   1.000 24.46165 ? 282  LEU   A CD1  1 
ATOM   1966 C  CD2  . LEU   A 1 277 ? 2.51410   -8.77253  2.24397   1.000 27.65279 ? 282  LEU   A CD2  1 
ATOM   1967 N  N    . VAL   A 1 278 ? -0.42096  -11.48619 5.18923   1.000 22.11632 ? 283  VAL   A N    1 
ATOM   1968 C  CA   . VAL   A 1 278 ? -1.45197  -11.63708 6.21123   1.000 23.94892 ? 283  VAL   A CA   1 
ATOM   1969 C  C    . VAL   A 1 278 ? -1.98897  -10.25204 6.53607   1.000 26.88712 ? 283  VAL   A C    1 
ATOM   1970 O  O    . VAL   A 1 278 ? -1.21397  -9.35200  6.87098   1.000 24.26609 ? 283  VAL   A O    1 
ATOM   1971 C  CB   . VAL   A 1 278 ? -0.90100  -12.30494 7.48131   1.000 22.30848 ? 283  VAL   A CB   1 
ATOM   1972 C  CG1  . VAL   A 1 278 ? -2.01601  -12.44482 8.52631   1.000 23.42456 ? 283  VAL   A CG1  1 
ATOM   1973 C  CG2  . VAL   A 1 278 ? -0.26400  -13.65198 7.15947   1.000 22.35264 ? 283  VAL   A CG2  1 
ATOM   1974 N  N    . TYR   A 1 279 ? -3.30797  -10.08104 6.45503   1.000 23.56954 ? 284  TYR   A N    1 
ATOM   1975 C  CA   . TYR   A 1 279 ? -3.96197  -8.83999  6.85588   1.000 25.44753 ? 284  TYR   A CA   1 
ATOM   1976 C  C    . TYR   A 1 279 ? -4.55300  -8.97684  8.25088   1.000 23.68988 ? 284  TYR   A C    1 
ATOM   1977 O  O    . TYR   A 1 279 ? -5.13000  -10.01280 8.60199   1.000 23.90365 ? 284  TYR   A O    1 
ATOM   1978 C  CB   . TYR   A 1 279 ? -5.07296  -8.45210  5.87982   1.000 22.19069 ? 284  TYR   A CB   1 
ATOM   1979 C  CG   . TYR   A 1 279 ? -4.55793  -7.82024  4.62276   1.000 20.07048 ? 284  TYR   A CG   1 
ATOM   1980 C  CD1  . TYR   A 1 279 ? -3.86592  -8.57835  3.66985   1.000 22.38047 ? 284  TYR   A CD1  1 
ATOM   1981 C  CD2  . TYR   A 1 279 ? -4.73692  -6.45227  4.38160   1.000 25.58103 ? 284  TYR   A CD2  1 
ATOM   1982 C  CE1  . TYR   A 1 279 ? -3.38290  -7.98748  2.49979   1.000 21.50238 ? 284  TYR   A CE1  1 
ATOM   1983 C  CE2  . TYR   A 1 279 ? -4.24590  -5.84540  3.22054   1.000 18.14050 ? 284  TYR   A CE2  1 
ATOM   1984 C  CZ   . TYR   A 1 279 ? -3.57989  -6.61450  2.28764   1.000 23.06804 ? 284  TYR   A CZ   1 
ATOM   1985 O  OH   . TYR   A 1 279 ? -3.11987  -6.02663  1.13258   1.000 25.80760 ? 284  TYR   A OH   1 
ATOM   1986 N  N    . ILE   A 1 280 ? -4.39700  -7.93275  9.04977   1.000 21.65896 ? 285  ILE   A N    1 
ATOM   1987 C  CA   . ILE   A 1 280 ? -5.00402  -7.87960  10.37076  1.000 23.76312 ? 285  ILE   A CA   1 
ATOM   1988 C  C    . ILE   A 1 280 ? -5.77202  -6.56859  10.47360  1.000 24.65495 ? 285  ILE   A C    1 
ATOM   1989 O  O    . ILE   A 1 280 ? -5.22901  -5.50563  10.15349  1.000 24.19658 ? 285  ILE   A O    1 
ATOM   1990 C  CB   . ILE   A 1 280 ? -3.95404  -8.00748  11.49279  1.000 20.26569 ? 285  ILE   A CB   1 
ATOM   1991 C  CG1  . ILE   A 1 280 ? -3.07504  -9.24051  11.24394  1.000 24.11692 ? 285  ILE   A CG1  1 
ATOM   1992 C  CG2  . ILE   A 1 280 ? -4.65207  -8.11533  12.84779  1.000 22.07005 ? 285  ILE   A CG2  1 
ATOM   1993 C  CD1  . ILE   A 1 280 ? -2.02106  -9.51540  12.33398  1.000 25.63084 ? 285  ILE   A CD1  1 
ATOM   1994 N  N    . TRP   A 1 281 ? -7.03503  -6.65354  10.89359  1.000 26.22282 ? 286  TRP   A N    1 
ATOM   1995 C  CA   . TRP   A 1 281 ? -7.92503  -5.51052  11.01945  1.000 27.76059 ? 286  TRP   A CA   1 
ATOM   1996 C  C    . TRP   A 1 281 ? -8.38205  -5.35336  12.46142  1.000 27.34315 ? 286  TRP   A C    1 
ATOM   1997 O  O    . TRP   A 1 281 ? -8.55906  -6.34028  13.19253  1.000 24.89082 ? 286  TRP   A O    1 
ATOM   1998 C  CB   . TRP   A 1 281 ? -9.19501  -5.65861  10.17144  1.000 26.39458 ? 286  TRP   A CB   1 
ATOM   1999 C  CG   . TRP   A 1 281 ? -9.10199  -5.65078  8.67144   1.000 26.47353 ? 286  TRP   A CG   1 
ATOM   2000 C  CD1  . TRP   A 1 281 ? -9.30497  -4.57887  7.84532   1.000 26.15087 ? 286  TRP   A CD1  1 
ATOM   2001 C  CD2  . TRP   A 1 281 ? -8.88498  -6.78487  7.80857   1.000 26.57865 ? 286  TRP   A CD2  1 
ATOM   2002 N  NE1  . TRP   A 1 281 ? -9.20295  -4.96901  6.52437   1.000 26.44816 ? 286  TRP   A NE1  1 
ATOM   2003 C  CE2  . TRP   A 1 281 ? -8.94796  -6.31602  6.47552   1.000 25.92985 ? 286  TRP   A CE2  1 
ATOM   2004 C  CE3  . TRP   A 1 281 ? -8.63499  -8.14785  8.03273   1.000 21.95852 ? 286  TRP   A CE3  1 
ATOM   2005 C  CZ2  . TRP   A 1 281 ? -8.75694  -7.16514  5.36562   1.000 27.50970 ? 286  TRP   A CZ2  1 
ATOM   2006 C  CZ3  . TRP   A 1 281 ? -8.44797  -8.99197  6.92982   1.000 24.75104 ? 286  TRP   A CZ3  1 
ATOM   2007 C  CH2  . TRP   A 1 281 ? -8.51495  -8.49711  5.61477   1.000 25.69704 ? 286  TRP   A CH2  1 
ATOM   2008 N  N    . ASN   A 1 282 ? -8.61505  -4.10231  12.85628  1.000 28.47553 ? 287  ASN   A N    1 
ATOM   2009 C  CA   . ASN   A 1 282 ? -9.32507  -3.83017  14.10224  1.000 25.99408 ? 287  ASN   A CA   1 
ATOM   2010 C  C    . ASN   A 1 282 ? -10.78607 -4.23419  13.92626  1.000 25.60691 ? 287  ASN   A C    1 
ATOM   2011 O  O    . ASN   A 1 282 ? -11.48005 -3.71628  13.04419  1.000 30.90966 ? 287  ASN   A O    1 
ATOM   2012 C  CB   . ASN   A 1 282 ? -9.19707  -2.35313  14.47608  1.000 25.64484 ? 287  ASN   A CB   1 
ATOM   2013 C  CG   . ASN   A 1 282 ? -9.93309  -2.01199  15.76203  1.000 32.94536 ? 287  ASN   A CG   1 
ATOM   2014 O  OD1  . ASN   A 1 282 ? -11.08309 -2.41296  15.96705  1.000 30.49343 ? 287  ASN   A OD1  1 
ATOM   2015 N  ND2  . ASN   A 1 282 ? -9.27210  -1.27289  16.63596  1.000 32.89340 ? 287  ASN   A ND2  1 
ATOM   2016 N  N    . LEU   A 1 283 ? -11.25408 -5.17510  14.74736  1.000 26.24572 ? 288  LEU   A N    1 
ATOM   2017 C  CA   . LEU   A 1 283 ? -12.59508 -5.71411  14.54040  1.000 29.64935 ? 288  LEU   A CA   1 
ATOM   2018 C  C    . LEU   A 1 283 ? -13.64708 -4.61111  14.58226  1.000 33.82829 ? 288  LEU   A C    1 
ATOM   2019 O  O    . LEU   A 1 283 ? -14.55007 -4.56820  13.73824  1.000 29.30745 ? 288  LEU   A O    1 
ATOM   2020 C  CB   . LEU   A 1 283 ? -12.89410 -6.79700  15.58351  1.000 28.69574 ? 288  LEU   A CB   1 
ATOM   2021 C  CG   . LEU   A 1 283 ? -14.19810 -7.59201  15.39158  1.000 34.08192 ? 288  LEU   A CG   1 
ATOM   2022 C  CD1  . LEU   A 1 283 ? -14.17112 -8.93993  16.11573  1.000 30.62209 ? 288  LEU   A CD1  1 
ATOM   2023 C  CD2  . LEU   A 1 283 ? -15.41111 -6.79096  15.85747  1.000 36.52015 ? 288  LEU   A CD2  1 
ATOM   2024 N  N    . GLN   A 1 284 ? -13.53409 -3.70000  15.54816  1.000 34.10251 ? 289  GLN   A N    1 
ATOM   2025 C  CA   . GLN   A 1 284 ? -14.55309 -2.67897  15.76303  1.000 34.36858 ? 289  GLN   A CA   1 
ATOM   2026 C  C    . GLN   A 1 284 ? -14.48407 -1.57909  14.71491  1.000 31.46546 ? 289  GLN   A C    1 
ATOM   2027 O  O    . GLN   A 1 284 ? -15.51506 -1.17714  14.16685  1.000 30.34409 ? 289  GLN   A O    1 
ATOM   2028 C  CB   . GLN   A 1 284 ? -14.40611 -2.08782  17.16597  1.000 36.93634 ? 289  GLN   A CB   1 
ATOM   2029 C  CG   . GLN   A 1 284 ? -14.87213 -3.02869  18.26306  1.000 41.76967 ? 289  GLN   A CG   1 
ATOM   2030 C  CD   . GLN   A 1 284 ? -16.30913 -3.49071  18.06509  1.000 53.61881 ? 289  GLN   A CD   1 
ATOM   2031 O  OE1  . GLN   A 1 284 ? -17.12612 -2.78277  17.46000  1.000 50.55026 ? 289  GLN   A OE1  1 
ATOM   2032 N  NE2  . GLN   A 1 284 ? -16.62314 -4.68565  18.56922  1.000 47.74447 ? 289  GLN   A NE2  1 
ATOM   2033 N  N    . THR   A 1 285 ? -13.27906 -1.08112  14.42387  1.000 31.37852 ? 290  THR   A N    1 
ATOM   2034 C  CA   . THR   A 1 285 ? -13.12405 0.05978   13.53275  1.000 33.85767 ? 290  THR   A CA   1 
ATOM   2035 C  C    . THR   A 1 285 ? -12.97602 -0.32739  12.06879  1.000 35.44693 ? 290  THR   A C    1 
ATOM   2036 O  O    . THR   A 1 285 ? -13.13801 0.53352   11.19670  1.000 27.10737 ? 290  THR   A O    1 
ATOM   2037 C  CB   . THR   A 1 285 ? -11.90205 0.88782   13.93068  1.000 35.85547 ? 290  THR   A CB   1 
ATOM   2038 O  OG1  . THR   A 1 285 ? -10.71204 0.22076   13.49277  1.000 31.70369 ? 290  THR   A OG1  1 
ATOM   2039 C  CG2  . THR   A 1 285 ? -11.85607 1.05898   15.43566  1.000 39.83519 ? 290  THR   A CG2  1 
ATOM   2040 N  N    . LYS   A 1 286 ? -12.63702 -1.58142  11.77594  1.000 33.64933 ? 291  LYS   A N    1 
ATOM   2041 C  CA   . LYS   A 1 286 ? -12.47000 -2.06657  10.41299  1.000 27.62926 ? 291  LYS   A CA   1 
ATOM   2042 C  C    . LYS   A 1 286 ? -11.19799 -1.54865  9.76396   1.000 33.46581 ? 291  LYS   A C    1 
ATOM   2043 O  O    . LYS   A 1 286 ? -10.98097 -1.78078  8.57299   1.000 31.46690 ? 291  LYS   A O    1 
ATOM   2044 C  CB   . LYS   A 1 286 ? -13.68299 -1.70566  9.55094   1.000 25.56303 ? 291  LYS   A CB   1 
ATOM   2045 C  CG   . LYS   A 1 286 ? -14.99300 -2.24159  10.13397  1.000 32.73265 ? 291  LYS   A CG   1 
ATOM   2046 C  CD   . LYS   A 1 286 ? -16.20899 -1.66467  9.42489   1.000 31.50701 ? 291  LYS   A CD   1 
ATOM   2047 C  CE   . LYS   A 1 286 ? -16.38399 -0.18263  9.73372   1.000 43.27382 ? 291  LYS   A CE   1 
ATOM   2048 N  NZ   . LYS   A 1 286 ? -17.42497 0.43628   8.85964   1.000 36.03128 ? 291  LYS   A NZ   1 
ATOM   2049 N  N    . GLU   A 1 287 ? -10.34500 -0.86157  10.51290  1.000 29.47130 ? 292  GLU   A N    1 
ATOM   2050 C  CA   . GLU   A 1 287 ? -9.08799  -0.35563  9.97186   1.000 29.02282 ? 292  GLU   A CA   1 
ATOM   2051 C  C    . GLU   A 1 287 ? -8.04499  -1.46764  9.90400   1.000 27.54617 ? 292  GLU   A C    1 
ATOM   2052 O  O    . GLU   A 1 287 ? -7.94001  -2.28754  10.81509  1.000 27.66973 ? 292  GLU   A O    1 
ATOM   2053 C  CB   . GLU   A 1 287 ? -8.57200  0.77946   10.85674  1.000 38.12056 ? 292  GLU   A CB   1 
ATOM   2054 C  CG   . GLU   A 1 287 ? -7.77098  1.83838   10.13264  1.000 55.29428 ? 292  GLU   A CG   1 
ATOM   2055 C  CD   . GLU   A 1 287 ? -8.64697  2.71729   9.26653   1.000 61.39822 ? 292  GLU   A CD   1 
ATOM   2056 O  OE1  . GLU   A 1 287 ? -9.61997  3.28935   9.80645   1.000 62.22821 ? 292  GLU   A OE1  1 
ATOM   2057 O  OE2  . GLU   A 1 287 ? -8.37595  2.82615   8.04752   1.000 62.19048 ? 292  GLU   A OE2  1 
ATOM   2058 N  N    . ILE   A 1 288 ? -7.24898  -1.47276  8.83701   1.000 28.91772 ? 293  ILE   A N    1 
ATOM   2059 C  CA   . ILE   A 1 288 ? -6.11998  -2.39378  8.76213   1.000 30.62685 ? 293  ILE   A CA   1 
ATOM   2060 C  C    . ILE   A 1 288 ? -5.07299  -1.95167  9.77710   1.000 31.43913 ? 293  ILE   A C    1 
ATOM   2061 O  O    . ILE   A 1 288 ? -4.61499  -0.80467  9.75298   1.000 30.65309 ? 293  ILE   A O    1 
ATOM   2062 C  CB   . ILE   A 1 288 ? -5.53496  -2.43693  7.34515   1.000 27.71456 ? 293  ILE   A CB   1 
ATOM   2063 C  CG1  . ILE   A 1 288 ? -6.56094  -2.98904  6.34719   1.000 24.52248 ? 293  ILE   A CG1  1 
ATOM   2064 C  CG2  . ILE   A 1 288 ? -4.24296  -3.25394  7.33026   1.000 28.55903 ? 293  ILE   A CG2  1 
ATOM   2065 C  CD1  . ILE   A 1 288 ? -6.07292  -2.94820  4.88619   1.000 25.06542 ? 293  ILE   A CD1  1 
ATOM   2066 N  N    . VAL   A 1 289 ? -4.70001  -2.84757  10.68920  1.000 27.24064 ? 294  VAL   A N    1 
ATOM   2067 C  CA   . VAL   A 1 289 ? -3.69603  -2.51446  11.69418  1.000 28.38632 ? 294  VAL   A CA   1 
ATOM   2068 C  C    . VAL   A 1 289 ? -2.34402  -3.16950  11.43128  1.000 28.44760 ? 294  VAL   A C    1 
ATOM   2069 O  O    . VAL   A 1 289 ? -1.33503  -2.69344  11.97124  1.000 29.32206 ? 294  VAL   A O    1 
ATOM   2070 C  CB   . VAL   A 1 289 ? -4.17805  -2.84830  13.12021  1.000 27.09387 ? 294  VAL   A CB   1 
ATOM   2071 C  CG1  . VAL   A 1 289 ? -5.37505  -1.96226  13.50010  1.000 26.74921 ? 294  VAL   A CG1  1 
ATOM   2072 C  CG2  . VAL   A 1 289 ? -4.49506  -4.33929  13.26037  1.000 27.24125 ? 294  VAL   A CG2  1 
ATOM   2073 N  N    . GLN   A 1 290 ? -2.27702  -4.22458  10.62440  1.000 24.40265 ? 295  GLN   A N    1 
ATOM   2074 C  CA   . GLN   A 1 290 ? -0.97901  -4.78263  10.27648  1.000 24.17556 ? 295  GLN   A CA   1 
ATOM   2075 C  C    . GLN   A 1 290 ? -1.11199  -5.60477  9.00757   1.000 28.13611 ? 295  GLN   A C    1 
ATOM   2076 O  O    . GLN   A 1 290 ? -2.16499  -6.18379  8.73361   1.000 26.77974 ? 295  GLN   A O    1 
ATOM   2077 C  CB   . GLN   A 1 290 ? -0.40703  -5.64650  11.41558  1.000 29.67971 ? 295  GLN   A CB   1 
ATOM   2078 C  CG   . GLN   A 1 290 ? 1.07596   -5.40748  11.68958  1.000 29.93824 ? 295  GLN   A CG   1 
ATOM   2079 C  CD   . GLN   A 1 290 ? 1.69794   -6.39837  12.67570  1.000 29.73655 ? 295  GLN   A CD   1 
ATOM   2080 O  OE1  . GLN   A 1 290 ? 1.01193   -7.00628  13.50575  1.000 27.15932 ? 295  GLN   A OE1  1 
ATOM   2081 N  NE2  . GLN   A 1 290 ? 3.01194   -6.57539  12.57074  1.000 26.73999 ? 295  GLN   A NE2  1 
ATOM   2082 N  N    . LYS   A 1 291 ? -0.02398  -5.63886  8.23959   1.000 26.44814 ? 296  LYS   A N    1 
ATOM   2083 C  CA   . LYS   A 1 291 ? 0.13203   -6.54098  7.10769   1.000 24.97581 ? 296  LYS   A CA   1 
ATOM   2084 C  C    . LYS   A 1 291 ? 1.44603   -7.28197  7.29279   1.000 29.84587 ? 296  LYS   A C    1 
ATOM   2085 O  O    . LYS   A 1 291 ? 2.49403   -6.64896  7.41474   1.000 30.91640 ? 296  LYS   A O    1 
ATOM   2086 C  CB   . LYS   A 1 291 ? 0.11506   -5.76713  5.78660   1.000 30.61838 ? 296  LYS   A CB   1 
ATOM   2087 C  CG   . LYS   A 1 291 ? -1.26394  -5.16516  5.48352   1.000 26.22711 ? 296  LYS   A CG   1 
ATOM   2088 C  CD   . LYS   A 1 291 ? -1.16192  -3.80522  4.88837   1.000 38.07486 ? 296  LYS   A CD   1 
ATOM   2089 C  CE   . LYS   A 1 291 ? -0.82890  -3.85538  3.42838   1.000 40.62940 ? 296  LYS   A CE   1 
ATOM   2090 N  NZ   . LYS   A 1 291 ? -0.95689  -2.47745  2.86622   1.000 48.85359 ? 296  LYS   A NZ   1 
ATOM   2091 N  N    . LEU   A 1 292 ? 1.39702   -8.60996  7.33094   1.000 24.50913 ? 297  LEU   A N    1 
ATOM   2092 C  CA   . LEU   A 1 292 ? 2.58901   -9.40894  7.59305   1.000 24.77355 ? 297  LEU   A CA   1 
ATOM   2093 C  C    . LEU   A 1 292 ? 3.21503   -9.84909  6.27010   1.000 29.21375 ? 297  LEU   A C    1 
ATOM   2094 O  O    . LEU   A 1 292 ? 2.58104   -10.55717 5.47717   1.000 25.84888 ? 297  LEU   A O    1 
ATOM   2095 C  CB   . LEU   A 1 292 ? 2.25700   -10.62084 8.46517   1.000 22.05600 ? 297  LEU   A CB   1 
ATOM   2096 C  CG   . LEU   A 1 292 ? 1.41398   -10.33370 9.71513   1.000 25.48887 ? 297  LEU   A CG   1 
ATOM   2097 C  CD1  . LEU   A 1 292 ? 1.30196   -11.56660 10.58626  1.000 22.81388 ? 297  LEU   A CD1  1 
ATOM   2098 C  CD2  . LEU   A 1 292 ? 1.99497   -9.16261  10.51601  1.000 26.38547 ? 297  LEU   A CD2  1 
ATOM   2099 N  N    . GLN   A 1 293 ? 4.46504   -9.45012  6.04608   1.000 23.98358 ? 298  GLN   A N    1 
ATOM   2100 C  CA   . GLN   A 1 293 ? 5.16906   -9.76025  4.80813   1.000 24.40371 ? 298  GLN   A CA   1 
ATOM   2101 C  C    . GLN   A 1 293 ? 6.14505   -10.91824 4.99227   1.000 27.99264 ? 298  GLN   A C    1 
ATOM   2102 O  O    . GLN   A 1 293 ? 6.82703   -11.02213 6.01929   1.000 25.23770 ? 298  GLN   A O    1 
ATOM   2103 C  CB   . GLN   A 1 293 ? 5.92507   -8.53632  4.28900   1.000 30.99487 ? 298  GLN   A CB   1 
ATOM   2104 C  CG   . GLN   A 1 293 ? 6.78309   -8.86445  3.08505   1.000 38.06570 ? 298  GLN   A CG   1 
ATOM   2105 C  CD   . GLN   A 1 293 ? 7.37110   -7.63653  2.41593   1.000 47.58563 ? 298  GLN   A CD   1 
ATOM   2106 O  OE1  . GLN   A 1 293 ? 7.57910   -6.59946  3.04581   1.000 46.32422 ? 298  GLN   A OE1  1 
ATOM   2107 N  NE2  . GLN   A 1 293 ? 7.62312   -7.74867  1.11694   1.000 56.92145 ? 298  GLN   A NE2  1 
ATOM   2108 N  N    . GLY   A 1 294 ? 6.22506   -11.77535 3.98236   1.000 24.73623 ? 299  GLY   A N    1 
ATOM   2109 C  CA   . GLY   A 1 294 ? 7.21206   -12.83835 4.02050   1.000 31.40877 ? 299  GLY   A CA   1 
ATOM   2110 C  C    . GLY   A 1 294 ? 6.90707   -14.00645 3.11162   1.000 24.12531 ? 299  GLY   A C    1 
ATOM   2111 O  O    . GLY   A 1 294 ? 7.81807   -14.61551 2.55070   1.000 21.80945 ? 299  GLY   A O    1 
ATOM   2112 N  N    . HIS   A 1 295 ? 5.63207   -14.34346 2.95764   1.000 22.13164 ? 300  HIS   A N    1 
ATOM   2113 C  CA   . HIS   A 1 295 ? 5.28008   -15.42556 2.05775   1.000 22.54093 ? 300  HIS   A CA   1 
ATOM   2114 C  C    . HIS   A 1 295 ? 5.51010   -14.99972 0.61371   1.000 19.76893 ? 300  HIS   A C    1 
ATOM   2115 O  O    . HIS   A 1 295 ? 5.52911   -13.80976 0.29158   1.000 23.47175 ? 300  HIS   A O    1 
ATOM   2116 C  CB   . HIS   A 1 295 ? 3.82107   -15.84653 2.26778   1.000 21.26293 ? 300  HIS   A CB   1 
ATOM   2117 C  CG   . HIS   A 1 295 ? 3.59405   -16.62339 3.52586   1.000 20.12729 ? 300  HIS   A CG   1 
ATOM   2118 N  ND1  . HIS   A 1 295 ? 4.05604   -17.91237 3.69701   1.000 19.86951 ? 300  HIS   A ND1  1 
ATOM   2119 C  CD2  . HIS   A 1 295 ? 2.93103   -16.30526 4.66381   1.000 20.20070 ? 300  HIS   A CD2  1 
ATOM   2120 C  CE1  . HIS   A 1 295 ? 3.69202   -18.35324 4.88905   1.000 21.83056 ? 300  HIS   A CE1  1 
ATOM   2121 N  NE2  . HIS   A 1 295 ? 3.00302   -17.39917 5.49493   1.000 22.56858 ? 300  HIS   A NE2  1 
ATOM   2122 N  N    . THR   A 1 296 ? 5.69711   -15.98982 -0.25918  1.000 21.34592 ? 301  THR   A N    1 
ATOM   2123 C  CA   . THR   A 1 296 ? 5.94814   -15.75197 -1.67720  1.000 22.51471 ? 301  THR   A CA   1 
ATOM   2124 C  C    . THR   A 1 296 ? 4.81415   -16.25307 -2.57316  1.000 23.03996 ? 301  THR   A C    1 
ATOM   2125 O  O    . THR   A 1 296 ? 4.96717   -16.27821 -3.80316  1.000 20.68314 ? 301  THR   A O    1 
ATOM   2126 C  CB   . THR   A 1 296 ? 7.25714   -16.40903 -2.10211  1.000 22.75910 ? 301  THR   A CB   1 
ATOM   2127 O  OG1  . THR   A 1 296 ? 7.11614   -17.82701 -1.99995  1.000 24.05864 ? 301  THR   A OG1  1 
ATOM   2128 C  CG2  . THR   A 1 296 ? 8.41613   -15.94793 -1.20214  1.000 20.03376 ? 301  THR   A CG2  1 
ATOM   2129 N  N    . ASP   A 1 297 ? 3.69314   -16.66200 -1.98814  1.000 21.49667 ? 302  ASP   A N    1 
ATOM   2130 C  CA   . ASP   A 1 297 ? 2.51715   -17.08408 -2.75211  1.000 22.87934 ? 302  ASP   A CA   1 
ATOM   2131 C  C    . ASP   A 1 297 ? 1.28614   -16.78498 -1.91016  1.000 22.06924 ? 302  ASP   A C    1 
ATOM   2132 O  O    . ASP   A 1 297 ? 1.38512   -16.32186 -0.76921  1.000 20.87187 ? 302  ASP   A O    1 
ATOM   2133 C  CB   . ASP   A 1 297 ? 2.58115   -18.57512 -3.12794  1.000 22.52420 ? 302  ASP   A CB   1 
ATOM   2134 C  CG   . ASP   A 1 297 ? 1.70717   -18.91625 -4.33092  1.000 25.96209 ? 302  ASP   A CG   1 
ATOM   2135 O  OD1  . ASP   A 1 297 ? 0.94818   -18.03530 -4.77703  1.000 24.64453 ? 302  ASP   A OD1  1 
ATOM   2136 O  OD2  . ASP   A 1 297 ? 1.78517   -20.06031 -4.83779  1.000 24.96954 ? 302  ASP   A OD2  1 
ATOM   2137 N  N    . VAL   A 1 298 ? 0.11215   -17.04704 -2.49015  1.000 21.28315 ? 303  VAL   A N    1 
ATOM   2138 C  CA   . VAL   A 1 298 ? -1.13986  -16.75796 -1.79920  1.000 21.61427 ? 303  VAL   A CA   1 
ATOM   2139 C  C    . VAL   A 1 298 ? -1.08289  -17.31481 -0.39314  1.000 21.86426 ? 303  VAL   A C    1 
ATOM   2140 O  O    . VAL   A 1 298 ? -0.73690  -18.48178 -0.18901  1.000 23.26251 ? 303  VAL   A O    1 
ATOM   2141 C  CB   . VAL   A 1 298 ? -2.32685  -17.37104 -2.56615  1.000 20.03758 ? 303  VAL   A CB   1 
ATOM   2142 C  CG1  . VAL   A 1 298 ? -3.63987  -17.09095 -1.80521  1.000 19.55515 ? 303  VAL   A CG1  1 
ATOM   2143 C  CG2  . VAL   A 1 298 ? -2.37583  -16.84920 -4.00521  1.000 21.91926 ? 303  VAL   A CG2  1 
ATOM   2144 N  N    . VAL   A 1 299 ? -1.43890  -16.49470 0.58776   1.000 19.32746 ? 304  VAL   A N    1 
ATOM   2145 C  CA   . VAL   A 1 299 ? -1.57892  -16.96654 1.95881   1.000 19.63664 ? 304  VAL   A CA   1 
ATOM   2146 C  C    . VAL   A 1 299 ? -3.01193  -17.48052 2.08685   1.000 23.53697 ? 304  VAL   A C    1 
ATOM   2147 O  O    . VAL   A 1 299 ? -3.95293  -16.70850 2.29275   1.000 23.40199 ? 304  VAL   A O    1 
ATOM   2148 C  CB   . VAL   A 1 299 ? -1.26094  -15.87043 2.97370   1.000 19.97623 ? 304  VAL   A CB   1 
ATOM   2149 C  CG1  . VAL   A 1 299 ? -1.51796  -16.36528 4.38175   1.000 21.55606 ? 304  VAL   A CG1  1 
ATOM   2150 C  CG2  . VAL   A 1 299 ? 0.20507   -15.40646 2.80767   1.000 16.22823 ? 304  VAL   A CG2  1 
ATOM   2151 N  N    . ILE   A 1 300 ? -3.18693  -18.79054 1.94099   1.000 19.16546 ? 305  ILE   A N    1 
ATOM   2152 C  CA   . ILE   A 1 300 ? -4.54193  -19.31554 1.86103   1.000 19.55349 ? 305  ILE   A CA   1 
ATOM   2153 C  C    . ILE   A 1 300 ? -5.09496  -19.71739 3.22406   1.000 23.50711 ? 305  ILE   A C    1 
ATOM   2154 O  O    . ILE   A 1 300 ? -6.31996  -19.84237 3.37006   1.000 20.43805 ? 305  ILE   A O    1 
ATOM   2155 C  CB   . ILE   A 1 300 ? -4.59592  -20.49065 0.87415   1.000 22.79051 ? 305  ILE   A CB   1 
ATOM   2156 C  CG1  . ILE   A 1 300 ? -6.01991  -20.62071 0.31915   1.000 20.77075 ? 305  ILE   A CG1  1 
ATOM   2157 C  CG2  . ILE   A 1 300 ? -4.06594  -21.78258 1.54431   1.000 22.93293 ? 305  ILE   A CG2  1 
ATOM   2158 C  CD1  . ILE   A 1 300 ? -6.18490  -21.70582 -0.70474  1.000 24.51885 ? 305  ILE   A CD1  1 
ATOM   2159 N  N    . SER   A 1 301 ? -4.24197  -19.89628 4.23509   1.000 17.54524 ? 306  SER   A N    1 
ATOM   2160 C  CA   . SER   A 1 301 ? -4.69999  -20.30414 5.55713   1.000 19.82823 ? 306  SER   A CA   1 
ATOM   2161 C  C    . SER   A 1 301 ? -3.99601  -19.48602 6.63005   1.000 19.10656 ? 306  SER   A C    1 
ATOM   2162 O  O    . SER   A 1 301 ? -2.80301  -19.19904 6.52104   1.000 21.74535 ? 306  SER   A O    1 
ATOM   2163 C  CB   . SER   A 1 301 ? -4.43800  -21.80011 5.79830   1.000 18.31378 ? 306  SER   A CB   1 
ATOM   2164 O  OG   . SER   A 1 301 ? -4.81803  -22.18196 7.11534   1.000 19.40734 ? 306  SER   A OG   1 
ATOM   2165 N  N    . THR   A 1 302 ? -4.75102  -19.10690 7.65700   1.000 17.66388 ? 307  THR   A N    1 
ATOM   2166 C  CA   . THR   A 1 302 ? -4.20304  -18.50177 8.85594   1.000 20.32828 ? 307  THR   A CA   1 
ATOM   2167 C  C    . THR   A 1 302 ? -4.90706  -19.12464 10.04200  1.000 23.66818 ? 307  THR   A C    1 
ATOM   2168 O  O    . THR   A 1 302 ? -6.03406  -19.60765 9.92503   1.000 21.77251 ? 307  THR   A O    1 
ATOM   2169 C  CB   . THR   A 1 302 ? -4.39704  -16.98277 8.88777   1.000 21.92559 ? 307  THR   A CB   1 
ATOM   2170 O  OG1  . THR   A 1 302 ? -5.79203  -16.68578 8.77872   1.000 23.30905 ? 307  THR   A OG1  1 
ATOM   2171 C  CG2  . THR   A 1 302 ? -3.63801  -16.29590 7.73071   1.000 26.18008 ? 307  THR   A CG2  1 
ATOM   2172 N  N    . ALA   A 1 303 ? -4.23108  -19.13152 11.18501  1.000 23.66140 ? 308  ALA   A N    1 
ATOM   2173 C  CA   . ALA   A 1 303 ? -4.80510  -19.67138 12.40806  1.000 22.42292 ? 308  ALA   A CA   1 
ATOM   2174 C  C    . ALA   A 1 303 ? -4.27912  -18.85225 13.57498  1.000 22.67001 ? 308  ALA   A C    1 
ATOM   2175 O  O    . ALA   A 1 303 ? -3.16711  -18.32226 13.51494  1.000 23.09804 ? 308  ALA   A O    1 
ATOM   2176 C  CB   . ALA   A 1 303 ? -4.45511  -21.15436 12.59523  1.000 21.59720 ? 308  ALA   A CB   1 
ATOM   2177 N  N    . CYS   A 1 304 ? -5.08213  -18.75413 14.63596  1.000 22.58892 ? 309  CYS   A N    1 
ATOM   2178 C  CA   . CYS   A 1 304 ? -4.74215  -17.96000 15.81587  1.000 22.81139 ? 309  CYS   A CA   1 
ATOM   2179 C  C    . CYS   A 1 304 ? -4.63717  -18.87887 17.02398  1.000 23.92067 ? 309  CYS   A C    1 
ATOM   2180 O  O    . CYS   A 1 304 ? -5.52918  -19.69584 17.27905  1.000 24.39296 ? 309  CYS   A O    1 
ATOM   2181 C  CB   . CYS   A 1 304 ? -5.77715  -16.86397 16.07174  1.000 23.48165 ? 309  CYS   A CB   1 
ATOM   2182 S  SG   . CYS   A 1 304 ? -5.95012  -15.66512 14.74160  1.000 25.59522 ? 309  CYS   A SG   1 
ATOM   2183 N  N    . HIS   A 1 305 ? -3.54618  -18.75379 17.75498  1.000 25.51954 ? 310  HIS   A N    1 
ATOM   2184 C  CA   . HIS   A 1 305 ? -3.30720  -19.63867 18.87908  1.000 24.33958 ? 310  HIS   A CA   1 
ATOM   2185 C  C    . HIS   A 1 305 ? -4.39522  -19.44755 19.93704  1.000 23.20368 ? 310  HIS   A C    1 
ATOM   2186 O  O    . HIS   A 1 305 ? -4.87422  -18.32652 20.14191  1.000 24.77881 ? 310  HIS   A O    1 
ATOM   2187 C  CB   . HIS   A 1 305 ? -1.91921  -19.34661 19.45507  1.000 25.01262 ? 310  HIS   A CB   1 
ATOM   2188 C  CG   . HIS   A 1 305 ? -1.46923  -20.33450 20.47719  1.000 26.12662 ? 310  HIS   A CG   1 
ATOM   2189 N  ND1  . HIS   A 1 305 ? -1.83525  -20.24835 21.80317  1.000 27.10973 ? 310  HIS   A ND1  1 
ATOM   2190 C  CD2  . HIS   A 1 305 ? -0.67823  -21.42551 20.37232  1.000 25.58296 ? 310  HIS   A CD2  1 
ATOM   2191 C  CE1  . HIS   A 1 305 ? -1.29927  -21.25428 22.47029  1.000 25.14151 ? 310  HIS   A CE1  1 
ATOM   2192 N  NE2  . HIS   A 1 305 ? -0.58626  -21.97838 21.62738  1.000 23.67214 ? 310  HIS   A NE2  1 
ATOM   2193 N  N    . PRO   A 1 306 ? -4.82224  -20.51347 20.61815  1.000 25.70144 ? 311  PRO   A N    1 
ATOM   2194 C  CA   . PRO   A 1 306 ? -5.94725  -20.37836 21.56412  1.000 26.87288 ? 311  PRO   A CA   1 
ATOM   2195 C  C    . PRO   A 1 306 ? -5.64527  -19.53123 22.79903  1.000 32.11360 ? 311  PRO   A C    1 
ATOM   2196 O  O    . PRO   A 1 306 ? -6.59127  -19.02016 23.40896  1.000 31.20909 ? 311  PRO   A O    1 
ATOM   2197 C  CB   . PRO   A 1 306 ? -6.25526  -21.82832 21.95428  1.000 29.40101 ? 311  PRO   A CB   1 
ATOM   2198 C  CG   . PRO   A 1 306 ? -4.96626  -22.56735 21.70938  1.000 26.27010 ? 311  PRO   A CG   1 
ATOM   2199 C  CD   . PRO   A 1 306 ? -4.38024  -21.91149 20.48132  1.000 22.62327 ? 311  PRO   A CD   1 
ATOM   2200 N  N    . THR   A 1 307 ? -4.38427  -19.37119 23.20303  1.000 27.65063 ? 312  THR   A N    1 
ATOM   2201 C  CA   . THR   A 1 307 ? -4.12229  -18.63005 24.43896  1.000 31.43442 ? 312  THR   A CA   1 
ATOM   2202 C  C    . THR   A 1 307 ? -3.06628  -17.53807 24.28385  1.000 30.35190 ? 312  THR   A C    1 
ATOM   2203 O  O    . THR   A 1 307 ? -3.13729  -16.51300 24.96774  1.000 29.97974 ? 312  THR   A O    1 
ATOM   2204 C  CB   . THR   A 1 307 ? -3.72231  -19.58693 25.57407  1.000 27.53994 ? 312  THR   A CB   1 
ATOM   2205 O  OG1  . THR   A 1 307 ? -2.54631  -20.33197 25.22017  1.000 27.60497 ? 312  THR   A OG1  1 
ATOM   2206 C  CG2  . THR   A 1 307 ? -4.86832  -20.56489 25.89416  1.000 28.94211 ? 312  THR   A CG2  1 
ATOM   2207 N  N    . GLU   A 1 308 ? -2.08227  -17.72617 23.41089  1.000 25.51996 ? 313  GLU   A N    1 
ATOM   2208 C  CA   . GLU   A 1 308 ? -1.06626  -16.70520 23.18979  1.000 24.28900 ? 313  GLU   A CA   1 
ATOM   2209 C  C    . GLU   A 1 308 ? -1.34524  -15.92234 21.91070  1.000 26.66883 ? 313  GLU   A C    1 
ATOM   2210 O  O    . GLU   A 1 308 ? -2.08623  -16.36444 21.02674  1.000 26.36044 ? 313  GLU   A O    1 
ATOM   2211 C  CB   . GLU   A 1 308 ? 0.32874   -17.32422 23.10388  1.000 28.24513 ? 313  GLU   A CB   1 
ATOM   2212 C  CG   . GLU   A 1 308 ? 0.55772   -18.42711 24.08301  1.000 30.10000 ? 313  GLU   A CG   1 
ATOM   2213 C  CD   . GLU   A 1 308 ? 0.31470   -17.97495 25.49496  1.000 37.05821 ? 313  GLU   A CD   1 
ATOM   2214 O  OE1  . GLU   A 1 308 ? 0.82769   -16.90291 25.86284  1.000 34.20843 ? 313  GLU   A OE1  1 
ATOM   2215 O  OE2  . GLU   A 1 308 ? -0.41832  -18.67587 26.22702  1.000 39.01162 ? 313  GLU   A OE2  1 
ATOM   2216 N  N    . ASN   A 1 309 ? -0.73423  -14.74135 21.82158  1.000 27.64483 ? 314  ASN   A N    1 
ATOM   2217 C  CA   . ASN   A 1 309 ? -0.80921  -13.91349 20.61649  1.000 30.58475 ? 314  ASN   A CA   1 
ATOM   2218 C  C    . ASN   A 1 309 ? 0.15380   -14.46461 19.56356  1.000 26.12624 ? 314  ASN   A C    1 
ATOM   2219 O  O    . ASN   A 1 309 ? 1.20881   -13.89464 19.27152  1.000 24.61249 ? 314  ASN   A O    1 
ATOM   2220 C  CB   . ASN   A 1 309 ? -0.48021  -12.46345 20.93733  1.000 26.19325 ? 314  ASN   A CB   1 
ATOM   2221 C  CG   . ASN   A 1 309 ? -1.33023  -11.90833 22.03926  1.000 31.41582 ? 314  ASN   A CG   1 
ATOM   2222 O  OD1  . ASN   A 1 309 ? -2.50423  -12.25231 22.16828  1.000 29.13915 ? 314  ASN   A OD1  1 
ATOM   2223 N  ND2  . ASN   A 1 309 ? -0.74224  -11.03924 22.85217  1.000 32.32609 ? 314  ASN   A ND2  1 
ATOM   2224 N  N    . ILE   A 1 310 ? -0.23219  -15.60367 18.99268  1.000 23.11161 ? 315  ILE   A N    1 
ATOM   2225 C  CA   . ILE   A 1 310 ? 0.55982   -16.29678 17.98177  1.000 23.48822 ? 315  ILE   A CA   1 
ATOM   2226 C  C    . ILE   A 1 310 ? -0.34316  -16.54691 16.78479  1.000 26.49302 ? 315  ILE   A C    1 
ATOM   2227 O  O    . ILE   A 1 310 ? -1.49016  -16.98189 16.94982  1.000 23.40033 ? 315  ILE   A O    1 
ATOM   2228 C  CB   . ILE   A 1 310 ? 1.14681   -17.62573 18.50193  1.000 23.40750 ? 315  ILE   A CB   1 
ATOM   2229 C  CG1  . ILE   A 1 310 ? 2.13579   -17.38560 19.64692  1.000 28.52872 ? 315  ILE   A CG1  1 
ATOM   2230 C  CG2  . ILE   A 1 310 ? 1.84982   -18.37085 17.38002  1.000 26.83723 ? 315  ILE   A CG2  1 
ATOM   2231 C  CD1  . ILE   A 1 310 ? 2.69578   -18.67554 20.26307  1.000 24.93340 ? 315  ILE   A CD1  1 
ATOM   2232 N  N    . ILE   A 1 311 ? 0.16886   -16.27105 15.59176  1.000 23.15278 ? 316  ILE   A N    1 
ATOM   2233 C  CA   . ILE   A 1 311 ? -0.53212  -16.53618 14.33978  1.000 24.96998 ? 316  ILE   A CA   1 
ATOM   2234 C  C    . ILE   A 1 311 ? 0.28289   -17.53627 13.53891  1.000 23.48122 ? 316  ILE   A C    1 
ATOM   2235 O  O    . ILE   A 1 311 ? 1.51189   -17.43328 13.48191  1.000 25.39592 ? 316  ILE   A O    1 
ATOM   2236 C  CB   . ILE   A 1 311 ? -0.74810  -15.24627 13.51864  1.000 26.65588 ? 316  ILE   A CB   1 
ATOM   2237 C  CG1  . ILE   A 1 311 ? -1.88211  -14.41320 14.11253  1.000 21.91059 ? 316  ILE   A CG1  1 
ATOM   2238 C  CG2  . ILE   A 1 311 ? -1.05608  -15.57843 12.06667  1.000 23.30370 ? 316  ILE   A CG2  1 
ATOM   2239 C  CD1  . ILE   A 1 311 ? -2.00809  -13.04927 13.47737  1.000 20.76348 ? 316  ILE   A CD1  1 
ATOM   2240 N  N    . ALA   A 1 312 ? -0.39711  -18.50634 12.92800  1.000 22.34616 ? 317  ALA   A N    1 
ATOM   2241 C  CA   . ALA   A 1 312 ? 0.20491   -19.33945 11.89810  1.000 25.39267 ? 317  ALA   A CA   1 
ATOM   2242 C  C    . ALA   A 1 312 ? -0.38207  -18.98260 10.54006  1.000 24.86884 ? 317  ALA   A C    1 
ATOM   2243 O  O    . ALA   A 1 312 ? -1.59307  -18.76161 10.41501  1.000 20.86017 ? 317  ALA   A O    1 
ATOM   2244 C  CB   . ALA   A 1 312 ? -0.00510  -20.83342 12.16927  1.000 22.12480 ? 317  ALA   A CB   1 
ATOM   2245 N  N    . SER   A 1 313 ? 0.47795   -18.92872 9.52506   1.000 19.58614 ? 318  SER   A N    1 
ATOM   2246 C  CA   . SER   A 1 313 ? 0.04397   -18.69387 8.15403   1.000 22.75155 ? 318  SER   A CA   1 
ATOM   2247 C  C    . SER   A 1 313 ? 0.64298   -19.76597 7.25516   1.000 22.92950 ? 318  SER   A C    1 
ATOM   2248 O  O    . SER   A 1 313 ? 1.69797   -20.32794 7.55624   1.000 23.28025 ? 318  SER   A O    1 
ATOM   2249 C  CB   . SER   A 1 313 ? 0.46298   -17.29892 7.67988   1.000 21.49312 ? 318  SER   A CB   1 
ATOM   2250 O  OG   . SER   A 1 313 ? 1.87398   -17.15991 7.79789   1.000 22.35890 ? 318  SER   A OG   1 
ATOM   2251 N  N    . ALA   A 1 314 ? -0.03300  -20.05609 6.14518   1.000 19.52797 ? 319  ALA   A N    1 
ATOM   2252 C  CA   . ALA   A 1 314 ? 0.45801   -21.05619 5.20530   1.000 21.62270 ? 319  ALA   A CA   1 
ATOM   2253 C  C    . ALA   A 1 314 ? 0.12003   -20.62335 3.79124   1.000 25.29979 ? 319  ALA   A C    1 
ATOM   2254 O  O    . ALA   A 1 314 ? -0.93896  -20.03237 3.55316   1.000 19.21164 ? 319  ALA   A O    1 
ATOM   2255 C  CB   . ALA   A 1 314 ? -0.14500  -22.43116 5.46644   1.000 21.19454 ? 319  ALA   A CB   1 
ATOM   2256 N  N    . ALA   A 1 315 ? 1.01205   -20.94946 2.85029   1.000 18.28806 ? 320  ALA   A N    1 
ATOM   2257 C  CA   . ALA   A 1 315 ? 0.93107   -20.40961 1.49523   1.000 24.81896 ? 320  ALA   A CA   1 
ATOM   2258 C  C    . ALA   A 1 315 ? 0.91308   -21.53072 0.46336   1.000 21.87298 ? 320  ALA   A C    1 
ATOM   2259 O  O    . ALA   A 1 315 ? 1.20907   -22.69669 0.75249   1.000 22.69568 ? 320  ALA   A O    1 
ATOM   2260 C  CB   . ALA   A 1 315 ? 2.09408   -19.43264 1.20514   1.000 23.31460 ? 320  ALA   A CB   1 
ATOM   2261 N  N    . LEU   A 1 316 ? 0.57410   -21.14885 -0.76769  1.000 22.29162 ? 321  LEU   A N    1 
ATOM   2262 C  CA   . LEU   A 1 316 ? 0.31112   -22.11097 -1.83259  1.000 22.21032 ? 321  LEU   A CA   1 
ATOM   2263 C  C    . LEU   A 1 316 ? 1.58513   -22.61105 -2.51951  1.000 22.91608 ? 321  LEU   A C    1 
ATOM   2264 O  O    . LEU   A 1 316 ? 2.68912   -22.49700 -1.97751  1.000 22.71128 ? 321  LEU   A O    1 
ATOM   2265 C  CB   . LEU   A 1 316 ? -0.65386  -21.49708 -2.86067  1.000 18.53907 ? 321  LEU   A CB   1 
ATOM   2266 C  CG   . LEU   A 1 316 ? -2.08887  -21.28402 -2.35372  1.000 21.07472 ? 321  LEU   A CG   1 
ATOM   2267 C  CD1  . LEU   A 1 316 ? -2.98385  -20.77814 -3.49179  1.000 23.59513 ? 321  LEU   A CD1  1 
ATOM   2268 C  CD2  . LEU   A 1 316 ? -2.66889  -22.59895 -1.74958  1.000 19.13059 ? 321  LEU   A CD2  1 
ATOM   2269 N  N    . GLU   A 1 317 ? 1.42214   -23.18218 -3.71245  1.000 21.91796 ? 322  GLU   A N    1 
ATOM   2270 C  CA   . GLU   A 1 317 ? 2.42415   -24.08225 -4.28734  1.000 26.75584 ? 322  GLU   A CA   1 
ATOM   2271 C  C    . GLU   A 1 317 ? 3.77015   -23.40328 -4.51339  1.000 27.80735 ? 322  GLU   A C    1 
ATOM   2272 O  O    . GLU   A 1 317 ? 4.80515   -24.06828 -4.47030  1.000 24.47861 ? 322  GLU   A O    1 
ATOM   2273 C  CB   . GLU   A 1 317 ? 1.90617   -24.64539 -5.61428  1.000 24.61652 ? 322  GLU   A CB   1 
ATOM   2274 C  CG   . GLU   A 1 317 ? 2.79117   -25.69147 -6.25915  1.000 33.64984 ? 322  GLU   A CG   1 
ATOM   2275 C  CD   . GLU   A 1 317 ? 2.56116   -27.08441 -5.69600  1.000 35.91173 ? 322  GLU   A CD   1 
ATOM   2276 O  OE1  . GLU   A 1 317 ? 1.62115   -27.26931 -4.88200  1.000 32.65194 ? 322  GLU   A OE1  1 
ATOM   2277 O  OE2  . GLU   A 1 317 ? 3.32016   -28.00245 -6.07889  1.000 39.55457 ? 322  GLU   A OE2  1 
ATOM   2278 N  N    . ASN   A 1 318 ? 3.78616   -22.10531 -4.79953  1.000 24.20118 ? 323  ASN   A N    1 
ATOM   2279 C  CA   . ASN   A 1 318 ? 5.05617   -21.44435 -5.06959  1.000 26.48574 ? 323  ASN   A CA   1 
ATOM   2280 C  C    . ASN   A 1 318 ? 5.77215   -21.02221 -3.79962  1.000 29.01998 ? 323  ASN   A C    1 
ATOM   2281 O  O    . ASN   A 1 318 ? 6.80016   -20.34422 -3.87268  1.000 30.99010 ? 323  ASN   A O    1 
ATOM   2282 C  CB   . ASN   A 1 318 ? 4.84919   -20.22444 -5.96772  1.000 23.78865 ? 323  ASN   A CB   1 
ATOM   2283 C  CG   . ASN   A 1 318 ? 4.22921   -20.58459 -7.29769  1.000 38.54404 ? 323  ASN   A CG   1 
ATOM   2284 O  OD1  . ASN   A 1 318 ? 4.56321   -21.60866 -7.89158  1.000 39.75318 ? 323  ASN   A OD1  1 
ATOM   2285 N  ND2  . ASN   A 1 318 ? 3.31922   -19.74664 -7.77180  1.000 36.88096 ? 323  ASN   A ND2  1 
ATOM   2286 N  N    . ASP   A 1 319 ? 5.25713   -21.40908 -2.64059  1.000 22.59699 ? 324  ASP   A N    1 
ATOM   2287 C  CA   . ASP   A 1 319 ? 5.87011   -21.00694 -1.38762  1.000 23.43999 ? 324  ASP   A CA   1 
ATOM   2288 C  C    . ASP   A 1 319 ? 6.11910   -22.25985 -0.55648  1.000 25.25598 ? 324  ASP   A C    1 
ATOM   2289 O  O    . ASP   A 1 319 ? 7.26709   -22.55682 -0.21343  1.000 24.84661 ? 324  ASP   A O    1 
ATOM   2290 C  CB   . ASP   A 1 319 ? 4.97211   -19.97186 -0.68875  1.000 20.46451 ? 324  ASP   A CB   1 
ATOM   2291 C  CG   . ASP   A 1 319 ? 5.46709   -19.59471 0.70622   1.000 23.76286 ? 324  ASP   A CG   1 
ATOM   2292 O  OD1  . ASP   A 1 319 ? 5.88107   -20.48963 1.47332   1.000 21.94495 ? 324  ASP   A OD1  1 
ATOM   2293 O  OD2  . ASP   A 1 319 ? 5.41208   -18.39367 1.04208   1.000 24.09602 ? 324  ASP   A OD2  1 
ATOM   2294 N  N    . LYS   A 1 320 ? 5.05509   -23.00881 -0.24041  1.000 20.48141 ? 325  LYS   A N    1 
ATOM   2295 C  CA   . LYS   A 1 320 ? 5.10707   -24.30774 0.43173   1.000 23.38621 ? 325  LYS   A CA   1 
ATOM   2296 C  C    . LYS   A 1 320 ? 5.50005   -24.22858 1.90173   1.000 21.61316 ? 325  LYS   A C    1 
ATOM   2297 O  O    . LYS   A 1 320 ? 5.70704   -25.28251 2.53085   1.000 24.51567 ? 325  LYS   A O    1 
ATOM   2298 C  CB   . LYS   A 1 320 ? 6.06908   -25.28882 -0.26115  1.000 19.96127 ? 325  LYS   A CB   1 
ATOM   2299 C  CG   . LYS   A 1 320 ? 5.83310   -25.46298 -1.75113  1.000 26.48959 ? 325  LYS   A CG   1 
ATOM   2300 C  CD   . LYS   A 1 320 ? 6.82711   -26.48505 -2.33100  1.000 23.76699 ? 325  LYS   A CD   1 
ATOM   2301 C  CE   . LYS   A 1 320 ? 6.57513   -26.75521 -3.80098  1.000 24.28197 ? 325  LYS   A CE   1 
ATOM   2302 N  NZ   . LYS   A 1 320 ? 7.38213   -27.92027 -4.27883  1.000 28.05825 ? 325  LYS   A NZ   1 
ATOM   2303 N  N    . THR   A 1 321 ? 5.58904   -23.03951 2.48660   1.000 21.02747 ? 326  THR   A N    1 
ATOM   2304 C  CA   . THR   A 1 321 ? 6.01702   -22.93836 3.87359   1.000 20.18341 ? 326  THR   A CA   1 
ATOM   2305 C  C    . THR   A 1 321 ? 4.90501   -22.42326 4.78652   1.000 25.74219 ? 326  THR   A C    1 
ATOM   2306 O  O    . THR   A 1 321 ? 3.92902   -21.79730 4.35743   1.000 19.68353 ? 326  THR   A O    1 
ATOM   2307 C  CB   . THR   A 1 321 ? 7.26002   -22.04135 4.01051   1.000 22.54933 ? 326  THR   A CB   1 
ATOM   2308 O  OG1  . THR   A 1 321 ? 6.90503   -20.67137 3.81436   1.000 19.72126 ? 326  THR   A OG1  1 
ATOM   2309 C  CG2  . THR   A 1 321 ? 8.29704   -22.41347 2.97357   1.000 25.20217 ? 326  THR   A CG2  1 
ATOM   2310 N  N    . ILE   A 1 322 ? 5.07599   -22.72412 6.06856   1.000 24.88314 ? 327  ILE   A N    1 
ATOM   2311 C  CA   . ILE   A 1 322 ? 4.23197   -22.23999 7.15149   1.000 24.43581 ? 327  ILE   A CA   1 
ATOM   2312 C  C    . ILE   A 1 322 ? 5.05696   -21.24491 7.94739   1.000 25.45803 ? 327  ILE   A C    1 
ATOM   2313 O  O    . ILE   A 1 322 ? 6.26496   -21.44289 8.12843   1.000 21.60107 ? 327  ILE   A O    1 
ATOM   2314 C  CB   . ILE   A 1 322 ? 3.77195   -23.41689 8.03861   1.000 21.59497 ? 327  ILE   A CB   1 
ATOM   2315 C  CG1  . ILE   A 1 322 ? 2.94196   -24.40698 7.21071   1.000 23.47435 ? 327  ILE   A CG1  1 
ATOM   2316 C  CG2  . ILE   A 1 322 ? 3.02794   -22.91675 9.27154   1.000 23.94069 ? 327  ILE   A CG2  1 
ATOM   2317 C  CD1  . ILE   A 1 322 ? 3.01695   -25.84593 7.68987   1.000 22.37345 ? 327  ILE   A CD1  1 
ATOM   2318 N  N    . LYS   A 1 323 ? 4.41796   -20.17985 8.42826   1.000 21.83582 ? 328  LYS   A N    1 
ATOM   2319 C  CA   . LYS   A 1 323 ? 5.11795   -19.18777 9.23017   1.000 24.83681 ? 328  LYS   A CA   1 
ATOM   2320 C  C    . LYS   A 1 323 ? 4.39193   -18.95862 10.54513  1.000 27.15342 ? 328  LYS   A C    1 
ATOM   2321 O  O    . LYS   A 1 323 ? 3.15793   -18.92261 10.59610  1.000 25.76327 ? 328  LYS   A O    1 
ATOM   2322 C  CB   . LYS   A 1 323 ? 5.29597   -17.87085 8.45002   1.000 19.84693 ? 328  LYS   A CB   1 
ATOM   2323 C  CG   . LYS   A 1 323 ? 6.26399   -18.04399 7.25106   1.000 17.38388 ? 328  LYS   A CG   1 
ATOM   2324 C  CD   . LYS   A 1 323 ? 6.40801   -16.77308 6.41392   1.000 20.29854 ? 328  LYS   A CD   1 
ATOM   2325 C  CE   . LYS   A 1 323 ? 7.26002   -17.03922 5.15996   1.000 19.04029 ? 328  LYS   A CE   1 
ATOM   2326 N  NZ   . LYS   A 1 323 ? 8.72202   -17.17319 5.50000   1.000 22.41656 ? 328  LYS   A NZ   1 
ATOM   2327 N  N    . LEU   A 1 324 ? 5.17391   -18.84150 11.61313  1.000 22.08927 ? 329  LEU   A N    1 
ATOM   2328 C  CA   . LEU   A 1 324 ? 4.67989   -18.56335 12.95009  1.000 21.87615 ? 329  LEU   A CA   1 
ATOM   2329 C  C    . LEU   A 1 324 ? 5.08189   -17.14731 13.32694  1.000 26.39821 ? 329  LEU   A C    1 
ATOM   2330 O  O    . LEU   A 1 324 ? 6.25290   -16.76933 13.18592  1.000 24.97938 ? 329  LEU   A O    1 
ATOM   2331 C  CB   . LEU   A 1 324 ? 5.23087   -19.57624 13.96221  1.000 21.04954 ? 329  LEU   A CB   1 
ATOM   2332 C  CG   . LEU   A 1 324 ? 4.67487   -20.99126 13.75736  1.000 23.78813 ? 329  LEU   A CG   1 
ATOM   2333 C  CD1  . LEU   A 1 324 ? 5.39685   -22.04217 14.62949  1.000 20.85457 ? 329  LEU   A CD1  1 
ATOM   2334 C  CD2  . LEU   A 1 324 ? 3.18887   -20.98323 14.05733  1.000 25.58506 ? 329  LEU   A CD2  1 
ATOM   2335 N  N    . TRP   A 1 325 ? 4.11589   -16.37326 13.80684  1.000 23.58287 ? 330  TRP   A N    1 
ATOM   2336 C  CA   . TRP   A 1 325 ? 4.30589   -14.96622 14.12069  1.000 23.60403 ? 330  TRP   A CA   1 
ATOM   2337 C  C    . TRP   A 1 325 ? 3.85187   -14.72206 15.54765  1.000 24.21353 ? 330  TRP   A C    1 
ATOM   2338 O  O    . TRP   A 1 325 ? 2.90886   -15.35701 16.02571  1.000 27.81321 ? 330  TRP   A O    1 
ATOM   2339 C  CB   . TRP   A 1 325 ? 3.50091   -14.05632 13.18657  1.000 22.23011 ? 330  TRP   A CB   1 
ATOM   2340 C  CG   . TRP   A 1 325 ? 3.50393   -14.45148 11.74562  1.000 25.42771 ? 330  TRP   A CG   1 
ATOM   2341 C  CD1  . TRP   A 1 325 ? 2.83493   -15.50454 11.17672  1.000 23.51584 ? 330  TRP   A CD1  1 
ATOM   2342 C  CD2  . TRP   A 1 325 ? 4.16495   -13.76960 10.67555  1.000 25.13799 ? 330  TRP   A CD2  1 
ATOM   2343 N  NE1  . TRP   A 1 325 ? 3.05596   -15.52369 9.81473   1.000 22.15520 ? 330  TRP   A NE1  1 
ATOM   2344 C  CE2  . TRP   A 1 325 ? 3.86896   -14.47173 9.48362   1.000 24.09909 ? 330  TRP   A CE2  1 
ATOM   2345 C  CE3  . TRP   A 1 325 ? 4.98895   -12.64261 10.60944  1.000 26.39577 ? 330  TRP   A CE3  1 
ATOM   2346 C  CZ2  . TRP   A 1 325 ? 4.36399   -14.08287 8.24759   1.000 25.04365 ? 330  TRP   A CZ2  1 
ATOM   2347 C  CZ3  . TRP   A 1 325 ? 5.48097   -12.25175 9.37041   1.000 23.55256 ? 330  TRP   A CZ3  1 
ATOM   2348 C  CH2  . TRP   A 1 325 ? 5.17299   -12.97188 8.21048   1.000 26.09516 ? 330  TRP   A CH2  1 
ATOM   2349 N  N    . LYS   A 1 326 ? 4.50786   -13.77799 16.21556  1.000 25.20582 ? 331  LYS   A N    1 
ATOM   2350 C  CA   . LYS   A 1 326 ? 4.26684   -13.52884 17.62853  1.000 28.09173 ? 331  LYS   A CA   1 
ATOM   2351 C  C    . LYS   A 1 326 ? 4.10984   -12.03281 17.85836  1.000 21.60096 ? 331  LYS   A C    1 
ATOM   2352 O  O    . LYS   A 1 326 ? 4.87085   -11.22787 17.31428  1.000 24.96174 ? 331  LYS   A O    1 
ATOM   2353 C  CB   . LYS   A 1 326 ? 5.41782   -14.10875 18.47561  1.000 28.95426 ? 331  LYS   A CB   1 
ATOM   2354 C  CG   . LYS   A 1 326 ? 5.44480   -13.64859 19.92156  1.000 32.75109 ? 331  LYS   A CG   1 
ATOM   2355 C  CD   . LYS   A 1 326 ? 4.48679   -14.43349 20.77763  1.000 31.44877 ? 331  LYS   A CD   1 
ATOM   2356 C  CE   . LYS   A 1 326 ? 4.36777   -13.81633 22.17356  1.000 39.02445 ? 331  LYS   A CE   1 
ATOM   2357 N  NZ   . LYS   A 1 326 ? 5.56375   -14.09925 22.99861  1.000 33.74722 ? 331  LYS   A NZ   1 
ATOM   2358 N  N    . SER   A 1 327 ? 3.11083   -11.66272 18.65730  1.000 27.76199 ? 332  SER   A N    1 
ATOM   2359 C  CA   . SER   A 1 327 ? 2.81683   -10.26368 18.94614  1.000 28.60017 ? 332  SER   A CA   1 
ATOM   2360 C  C    . SER   A 1 327 ? 2.73581   -10.04552 20.45112  1.000 28.80608 ? 332  SER   A C    1 
ATOM   2361 O  O    . SER   A 1 327 ? 2.39179   -10.95443 21.20621  1.000 25.81762 ? 332  SER   A O    1 
ATOM   2362 C  CB   . SER   A 1 327 ? 1.48984   -9.82475  18.30007  1.000 27.91762 ? 332  SER   A CB   1 
ATOM   2363 O  OG   . SER   A 1 327 ? 1.14884   -8.49671  18.65592  1.000 28.20651 ? 332  SER   A OG   1 
ATOM   2364 N  N    . ASP   A 1 328 ? 3.03680   -8.81847  20.87999  1.000 30.65978 ? 333  ASP   A N    1 
ATOM   2365 C  CA   . ASP   A 1 328 ? 2.90678   -8.46732  22.28595  1.000 30.91235 ? 333  ASP   A CA   1 
ATOM   2366 C  C    . ASP   A 1 328 ? 1.46578   -8.17127  22.68989  1.000 36.86212 ? 333  ASP   A C    1 
ATOM   2367 O  O    . ASP   A 1 328 ? 1.17376   -8.12913  23.88888  1.000 35.51974 ? 333  ASP   A O    1 
ATOM   2368 C  CB   . ASP   A 1 328 ? 3.79578   -7.25828  22.60883  1.000 30.84608 ? 333  ASP   A CB   1 
ATOM   2369 C  CG   . ASP   A 1 328 ? 5.27378   -7.54731  22.39988  1.000 32.02770 ? 333  ASP   A CG   1 
ATOM   2370 O  OD1  . ASP   A 1 328 ? 5.73577   -8.62527  22.82901  1.000 32.78200 ? 333  ASP   A OD1  1 
ATOM   2371 O  OD2  . ASP   A 1 328 ? 5.97380   -6.71338  21.78380  1.000 36.25642 ? 333  ASP   A OD2  1 
ATOM   2372 N  N    . CYS   A 1 329 ? 0.56579   -7.96937  21.72885  1.000 32.49601 ? 334  CYS   A N    1 
ATOM   2373 C  CA   . CYS   A 1 329 ? -0.85121  -7.72533  22.01480  1.000 36.79257 ? 334  CYS   A CA   1 
ATOM   2374 C  C    . CYS   A 1 329 ? -1.74519  -8.16146  20.85084  1.000 37.02314 ? 334  CYS   A C    1 
ATOM   2375 O  O    . CYS   A 1 329 ? -1.28218  -8.77657  19.88391  1.000 36.81145 ? 334  CYS   A O    1 
ATOM   2376 C  CB   . CYS   A 1 329 ? -1.09421  -6.24930  22.31364  1.000 32.80825 ? 334  CYS   A CB   1 
ATOM   2377 S  SG   . CYS   A 1 329 ? -0.88318  -5.17046  20.87652  1.000 42.24598 ? 334  CYS   A SG   1 
ATOM   2378 O  OXT  . CYS   A 1 329 ? -2.95519  -7.91145  20.84879  1.000 38.31879 ? 334  CYS   A OXT  1 
ATOM   2379 N  N    . PHE   B 2 28  ? 4.61218   -20.18687 -42.55753 1.000 36.71084 ? 1080 PHE   B N    1 
ATOM   2380 C  CA   . PHE   B 2 28  ? 3.84204   -19.51716 -41.51045 1.000 47.60303 ? 1080 PHE   B CA   1 
ATOM   2381 C  C    . PHE   B 2 28  ? 4.48185   -18.19716 -41.08016 1.000 40.08644 ? 1080 PHE   B C    1 
ATOM   2382 O  O    . PHE   B 2 28  ? 5.17279   -18.12927 -40.06311 1.000 42.43161 ? 1080 PHE   B O    1 
ATOM   2383 C  CB   . PHE   B 2 28  ? 3.67009   -20.44841 -40.30463 1.000 39.75591 ? 1080 PHE   B CB   1 
ATOM   2384 C  CG   . PHE   B 2 28  ? 2.91226   -21.70244 -40.63091 1.000 47.67370 ? 1080 PHE   B CG   1 
ATOM   2385 C  CD1  . PHE   B 2 28  ? 1.52926   -21.68659 -40.71598 1.000 43.53845 ? 1080 PHE   B CD1  1 
ATOM   2386 C  CD2  . PHE   B 2 28  ? 3.58241   -22.88631 -40.89510 1.000 52.36763 ? 1080 PHE   B CD2  1 
ATOM   2387 C  CE1  . PHE   B 2 28  ? 0.82742   -22.83162 -41.03924 1.000 43.82895 ? 1080 PHE   B CE1  1 
ATOM   2388 C  CE2  . PHE   B 2 28  ? 2.88457   -24.04033 -41.21935 1.000 46.50169 ? 1080 PHE   B CE2  1 
ATOM   2389 C  CZ   . PHE   B 2 28  ? 1.50757   -24.01148 -41.29242 1.000 46.58223 ? 1080 PHE   B CZ   1 
ATOM   2390 N  N    . ARG   B 2 29  ? 4.22677   -17.15205 -41.85798 1.000 43.63560 ? 1081 ARG   B N    1 
ATOM   2391 C  CA   . ARG   B 2 29  ? 4.79359   -15.83303 -41.58570 1.000 39.46508 ? 1081 ARG   B CA   1 
ATOM   2392 C  C    . ARG   B 2 29  ? 3.98745   -15.12233 -40.50261 1.000 30.95554 ? 1081 ARG   B C    1 
ATOM   2393 O  O    . ARG   B 2 29  ? 2.76744   -14.96745 -40.64965 1.000 33.16112 ? 1081 ARG   B O    1 
ATOM   2394 C  CB   . ARG   B 2 29  ? 4.80656   -14.98679 -42.86154 1.000 39.31641 ? 1081 ARG   B CB   1 
ATOM   2395 C  CG   . ARG   B 2 29  ? 5.43038   -13.59574 -42.69924 1.000 42.86188 ? 1081 ARG   B CG   1 
ATOM   2396 C  CD   . ARG   B 2 29  ? 5.65237   -12.93246 -44.05610 1.000 43.59125 ? 1081 ARG   B CD   1 
ATOM   2397 N  NE   . ARG   B 2 29  ? 4.39839   -12.73847 -44.77514 1.000 49.42537 ? 1081 ARG   B NE   1 
ATOM   2398 C  CZ   . ARG   B 2 29  ? 3.70425   -11.60756 -44.79096 1.000 59.39347 ? 1081 ARG   B CZ   1 
ATOM   2399 N  NH1  . ARG   B 2 29  ? 4.13208   -10.52362 -44.15873 1.000 61.96415 ? 1081 ARG   B NH1  1 
ATOM   2400 N  NH2  . ARG   B 2 29  ? 2.55128   -11.56057 -45.45601 1.000 55.76052 ? 1081 ARG   B NH2  1 
ATOM   2401 N  N    . PRO   B 2 30  ? 4.62833   -14.67446 -39.42149 1.000 33.83296 ? 1082 PRO   B N    1 
ATOM   2402 C  CA   . PRO   B 2 30  ? 3.93018   -13.86173 -38.41337 1.000 34.73038 ? 1082 PRO   B CA   1 
ATOM   2403 C  C    . PRO   B 2 30  ? 3.36106   -12.58669 -39.01616 1.000 32.34204 ? 1082 PRO   B C    1 
ATOM   2404 O  O    . PRO   B 2 30  ? 4.04801   -11.84847 -39.72399 1.000 35.26900 ? 1082 PRO   B O    1 
ATOM   2405 C  CB   . PRO   B 2 30  ? 5.02308   -13.54379 -37.38725 1.000 41.14719 ? 1082 PRO   B CB   1 
ATOM   2406 C  CG   . PRO   B 2 30  ? 6.08222   -14.57962 -37.60939 1.000 38.34072 ? 1082 PRO   B CG   1 
ATOM   2407 C  CD   . PRO   B 2 30  ? 6.03634   -14.91535 -39.07346 1.000 36.63481 ? 1082 PRO   B CD   1 
ATOM   2408 N  N    . ILE   B 2 31  ? 2.09401   -12.32190 -38.70318 1.000 28.84197 ? 1083 ILE   B N    1 
ATOM   2409 C  CA   . ILE   B 2 31  ? 1.34090   -11.21789 -39.27601 1.000 26.86575 ? 1083 ILE   B CA   1 
ATOM   2410 C  C    . ILE   B 2 31  ? 0.93572   -10.20414 -38.21585 1.000 33.50814 ? 1083 ILE   B C    1 
ATOM   2411 O  O    . ILE   B 2 31  ? 0.91959   -8.99409  -38.47062 1.000 27.66388 ? 1083 ILE   B O    1 
ATOM   2412 C  CB   . ILE   B 2 31  ? 0.09001   -11.74590 -40.01818 1.000 31.21788 ? 1083 ILE   B CB   1 
ATOM   2413 C  CG1  . ILE   B 2 31  ? 0.49917   -12.48561 -41.28730 1.000 43.44221 ? 1083 ILE   B CG1  1 
ATOM   2414 C  CG2  . ILE   B 2 31  ? -0.87811  -10.62896 -40.31602 1.000 37.19755 ? 1083 ILE   B CG2  1 
ATOM   2415 C  CD1  . ILE   B 2 31  ? 1.46912   -11.70333 -42.14110 1.000 41.84763 ? 1083 ILE   B CD1  1 
ATOM   2416 N  N    . SER   B 2 32  ? 0.58872   -10.67840 -37.02595 1.000 32.08684 ? 1084 SER   B N    1 
ATOM   2417 C  CA   . SER   B 2 32  ? 0.09055   -9.82366  -35.96482 1.000 28.21386 ? 1084 SER   B CA   1 
ATOM   2418 C  C    . SER   B 2 32  ? 0.25957   -10.57389 -34.65495 1.000 27.76461 ? 1084 SER   B C    1 
ATOM   2419 O  O    . SER   B 2 32  ? 0.34572   -11.80488 -34.63718 1.000 25.31817 ? 1084 SER   B O    1 
ATOM   2420 C  CB   . SER   B 2 32  ? -1.37148  -9.44579  -36.21283 1.000 25.19878 ? 1084 SER   B CB   1 
ATOM   2421 O  OG   . SER   B 2 32  ? -1.85564  -8.61905  -35.18070 1.000 27.53187 ? 1084 SER   B OG   1 
ATOM   2422 N  N    . VAL   B 2 33  ? 0.35342   -9.81809  -33.56380 1.000 25.96692 ? 1085 VAL   B N    1 
ATOM   2423 C  CA   . VAL   B 2 33  ? 0.36942   -10.38834 -32.22391 1.000 22.87532 ? 1085 VAL   B CA   1 
ATOM   2424 C  C    . VAL   B 2 33  ? -0.39874  -9.44860  -31.31277 1.000 28.38035 ? 1085 VAL   B C    1 
ATOM   2425 O  O    . VAL   B 2 33  ? -0.38288  -8.22956  -31.50654 1.000 23.71237 ? 1085 VAL   B O    1 
ATOM   2426 C  CB   . VAL   B 2 33  ? 1.81142   -10.60426 -31.70687 1.000 29.50928 ? 1085 VAL   B CB   1 
ATOM   2427 C  CG1  . VAL   B 2 33  ? 2.52024   -9.24821  -31.52158 1.000 24.77586 ? 1085 VAL   B CG1  1 
ATOM   2428 C  CG2  . VAL   B 2 33  ? 1.80144   -11.38550 -30.41402 1.000 25.50465 ? 1085 VAL   B CG2  1 
ATOM   2429 N  N    . PHE   B 2 34  ? -1.08573  -10.01187 -30.31492 1.000 23.90841 ? 1086 PHE   B N    1 
ATOM   2430 C  CA   . PHE   B 2 34  ? -1.72089  -9.13514  -29.34279 1.000 25.61770 ? 1086 PHE   B CA   1 
ATOM   2431 C  C    . PHE   B 2 34  ? -1.96587  -9.89141  -28.05194 1.000 29.14684 ? 1086 PHE   B C    1 
ATOM   2432 O  O    . PHE   B 2 34  ? -2.06672  -11.11942 -28.04518 1.000 26.22504 ? 1086 PHE   B O    1 
ATOM   2433 C  CB   . PHE   B 2 34  ? -3.01994  -8.51719  -29.87874 1.000 22.66273 ? 1086 PHE   B CB   1 
ATOM   2434 C  CG   . PHE   B 2 34  ? -4.06679  -9.50624  -30.32498 1.000 26.73385 ? 1086 PHE   B CG   1 
ATOM   2435 C  CD1  . PHE   B 2 34  ? -4.05366  -10.01899 -31.60808 1.000 22.93640 ? 1086 PHE   B CD1  1 
ATOM   2436 C  CD2  . PHE   B 2 34  ? -5.12680  -9.84852  -29.48611 1.000 25.92679 ? 1086 PHE   B CD2  1 
ATOM   2437 C  CE1  . PHE   B 2 34  ? -5.03453  -10.90503 -32.03930 1.000 26.95572 ? 1086 PHE   B CE1  1 
ATOM   2438 C  CE2  . PHE   B 2 34  ? -6.11167  -10.72056 -29.90933 1.000 24.52989 ? 1086 PHE   B CE2  1 
ATOM   2439 C  CZ   . PHE   B 2 34  ? -6.06253  -11.25831 -31.19442 1.000 22.57809 ? 1086 PHE   B CZ   1 
ATOM   2440 N  N    . ARG   B 2 35  ? -2.00302  -9.14662  -26.95680 1.000 24.51024 ? 1087 ARG   B N    1 
ATOM   2441 C  CA   . ARG   B 2 35  ? -2.32102  -9.71091  -25.65593 1.000 23.23958 ? 1087 ARG   B CA   1 
ATOM   2442 C  C    . ARG   B 2 35  ? -3.65911  -9.16015  -25.20090 1.000 25.16328 ? 1087 ARG   B C    1 
ATOM   2443 O  O    . ARG   B 2 35  ? -4.24118  -8.28210  -25.84676 1.000 25.89905 ? 1087 ARG   B O    1 
ATOM   2444 C  CB   . ARG   B 2 35  ? -1.21711  -9.42496  -24.62781 1.000 33.09505 ? 1087 ARG   B CB   1 
ATOM   2445 C  CG   . ARG   B 2 35  ? -0.79329  -7.98694  -24.49852 1.000 30.32031 ? 1087 ARG   B CG   1 
ATOM   2446 C  CD   . ARG   B 2 35  ? 0.34264   -7.87499  -23.47644 1.000 32.64289 ? 1087 ARG   B CD   1 
ATOM   2447 N  NE   . ARG   B 2 35  ? -0.14840  -8.12931  -22.12651 1.000 31.27917 ? 1087 ARG   B NE   1 
ATOM   2448 C  CZ   . ARG   B 2 35  ? 0.50363   -8.82340  -21.20361 1.000 35.02282 ? 1087 ARG   B CZ   1 
ATOM   2449 N  NH1  . ARG   B 2 35  ? 1.69970   -9.33221  -21.44064 1.000 40.47377 ? 1087 ARG   B NH1  1 
ATOM   2450 N  NH2  . ARG   B 2 35  ? -0.06541  -9.02170  -20.01468 1.000 30.19566 ? 1087 ARG   B NH2  1 
ATOM   2451 N  N    . GLU   B 2 36  ? -4.16410  -9.71042  -24.09903 1.000 26.26650 ? 1088 GLU   B N    1 
ATOM   2452 C  CA   . GLU   B 2 36  ? -5.47718  -9.30567  -23.62402 1.000 27.03088 ? 1088 GLU   B CA   1 
ATOM   2453 C  C    . GLU   B 2 36  ? -5.43438  -7.87777  -23.09475 1.000 25.16551 ? 1088 GLU   B C    1 
ATOM   2454 O  O    . GLU   B 2 36  ? -4.58647  -7.53382  -22.26764 1.000 29.92049 ? 1088 GLU   B O    1 
ATOM   2455 C  CB   . GLU   B 2 36  ? -5.97212  -10.25594 -22.53423 1.000 28.17597 ? 1088 GLU   B CB   1 
ATOM   2456 C  CG   . GLU   B 2 36  ? -7.38819  -9.92520  -22.07124 1.000 30.05674 ? 1088 GLU   B CG   1 
ATOM   2457 C  CD   . GLU   B 2 36  ? -7.88213  -10.87146 -20.99545 1.000 33.76433 ? 1088 GLU   B CD   1 
ATOM   2458 O  OE1  . GLU   B 2 36  ? -7.05307  -11.60447 -20.40954 1.000 30.85594 ? 1088 GLU   B OE1  1 
ATOM   2459 O  OE2  . GLU   B 2 36  ? -9.10215  -10.87866 -20.73852 1.000 36.60465 ? 1088 GLU   B OE2  1 
ATOM   2460 N  N    . ALA   B 2 37  ? -6.37446  -7.05680  -23.54965 1.000 26.60729 ? 1089 ALA   B N    1 
ATOM   2461 C  CA   . ALA   B 2 37  ? -6.44165  -5.67389  -23.10139 1.000 33.45807 ? 1089 ALA   B CA   1 
ATOM   2462 C  C    . ALA   B 2 37  ? -6.79774  -5.59521  -21.62239 1.000 40.15357 ? 1089 ALA   B C    1 
ATOM   2463 O  O    . ALA   B 2 37  ? -7.53267  -6.42740  -21.09459 1.000 43.78549 ? 1089 ALA   B O    1 
ATOM   2464 C  CB   . ALA   B 2 37  ? -7.47470  -4.89886  -23.91730 1.000 30.31183 ? 1089 ALA   B CB   1 
ATOM   2465 N  N    . ASN   B 2 38  ? -6.26990  -4.57528  -20.94917 1.000 51.92006 ? 1090 ASN   B N    1 
ATOM   2466 C  CA   . ASN   B 2 38  ? -6.66502  -4.16858  -19.60512 1.000 58.35268 ? 1090 ASN   B CA   1 
ATOM   2467 C  C    . ASN   B 2 38  ? -6.10297  -5.08272  -18.51326 1.000 66.34517 ? 1090 ASN   B C    1 
ATOM   2468 O  O    . ASN   B 2 38  ? -6.14108  -4.70494  -17.34119 1.000 71.16506 ? 1090 ASN   B O    1 
ATOM   2469 C  CB   . ASN   B 2 38  ? -8.19604  -4.10480  -19.42919 1.000 62.10829 ? 1090 ASN   B CB   1 
ATOM   2470 C  CG   . ASN   B 2 38  ? -8.87809  -3.27168  -20.50307 1.000 66.42059 ? 1090 ASN   B CG   1 
ATOM   2471 O  OD1  . ASN   B 2 38  ? -8.40420  -2.18655  -20.85884 1.000 60.54447 ? 1090 ASN   B OD1  1 
ATOM   2472 N  ND2  . ASN   B 2 38  ? -10.00300 -3.77672  -21.02422 1.000 48.54750 ? 1090 ASN   B ND2  1 
ATOM   2473 N  N    . GLU   B 2 39  ? -5.60081  -6.26759  -18.84246 1.000 57.61523 ? 1091 GLU   B N    1 
ATOM   2474 C  CA   . GLU   B 2 39  ? -5.26774  -7.26974  -17.84063 1.000 56.63524 ? 1091 GLU   B CA   1 
ATOM   2475 C  C    . GLU   B 2 39  ? -3.76375  -7.32560  -17.62156 1.000 56.28898 ? 1091 GLU   B C    1 
ATOM   2476 O  O    . GLU   B 2 39  ? -2.98170  -7.26532  -18.57350 1.000 60.78995 ? 1091 GLU   B O    1 
ATOM   2477 C  CB   . GLU   B 2 39  ? -5.79155  -8.64473  -18.26092 1.000 50.06658 ? 1091 GLU   B CB   1 
ATOM   2478 C  CG   . GLU   B 2 39  ? -7.30153  -8.69087  -18.47701 1.000 48.95955 ? 1091 GLU   B CG   1 
ATOM   2479 C  CD   . GLU   B 2 39  ? -8.08462  -8.57421  -17.17903 1.000 65.03740 ? 1091 GLU   B CD   1 
ATOM   2480 O  OE1  . GLU   B 2 39  ? -7.44871  -8.31633  -16.12894 1.000 62.42151 ? 1091 GLU   B OE1  1 
ATOM   2481 O  OE2  . GLU   B 2 39  ? -9.33260  -8.74835  -17.21513 1.000 65.35289 ? 1091 GLU   B OE2  1 
ATOM   2482 N  N    . ASP   B 2 40  ? -3.36380  -7.44079  -16.35256 1.000 64.13853 ? 1092 ASP   B N    1 
ATOM   2483 C  CA   . ASP   B 2 40  ? -1.94181  -7.48268  -16.02949 1.000 59.83625 ? 1092 ASP   B CA   1 
ATOM   2484 C  C    . ASP   B 2 40  ? -1.31063  -8.78651  -16.49570 1.000 55.87079 ? 1092 ASP   B C    1 
ATOM   2485 O  O    . ASP   B 2 40  ? -0.19260  -8.79328  -17.02664 1.000 54.50061 ? 1092 ASP   B O    1 
ATOM   2486 C  CB   . ASP   B 2 40  ? -1.74992  -7.28594  -14.52544 1.000 65.03615 ? 1092 ASP   B CB   1 
ATOM   2487 C  CG   . ASP   B 2 40  ? -0.63806  -6.30786  -14.20719 1.000 77.99579 ? 1092 ASP   B CG   1 
ATOM   2488 O  OD1  . ASP   B 2 40  ? -0.41413  -5.37968  -15.01601 1.000 73.86901 ? 1092 ASP   B OD1  1 
ATOM   2489 O  OD2  . ASP   B 2 40  ? -0.00010  -6.45899  -13.13719 1.000 77.85162 ? 1092 ASP   B OD2  1 
ATOM   2490 N  N    . GLU   B 2 41  ? -2.00351  -9.89864  -16.29495 1.000 46.53103 ? 1093 GLU   B N    1 
ATOM   2491 C  CA   . GLU   B 2 41  ? -1.62032  -11.18148 -16.86417 1.000 46.20590 ? 1093 GLU   B CA   1 
ATOM   2492 C  C    . GLU   B 2 41  ? -2.64022  -11.52440 -17.94029 1.000 39.74643 ? 1093 GLU   B C    1 
ATOM   2493 O  O    . GLU   B 2 41  ? -3.83622  -11.62760 -17.65437 1.000 38.75561 ? 1093 GLU   B O    1 
ATOM   2494 C  CB   . GLU   B 2 41  ? -1.56725  -12.25868 -15.78537 1.000 50.63031 ? 1093 GLU   B CB   1 
ATOM   2495 C  CG   . GLU   B 2 41  ? -0.89037  -11.79984 -14.50625 1.000 54.72813 ? 1093 GLU   B CG   1 
ATOM   2496 C  CD   . GLU   B 2 41  ? -1.18732  -12.71210 -13.33343 1.000 71.12029 ? 1093 GLU   B CD   1 
ATOM   2497 O  OE1  . GLU   B 2 41  ? -2.21139  -12.47535 -12.65444 1.000 59.62662 ? 1093 GLU   B OE1  1 
ATOM   2498 O  OE2  . GLU   B 2 41  ? -0.40122  -13.66204 -13.10157 1.000 71.62073 ? 1093 GLU   B OE2  1 
ATOM   2499 N  N    . SER   B 2 42  ? -2.16713  -11.66511 -19.17429 1.000 30.53383 ? 1094 SER   B N    1 
ATOM   2500 C  CA   . SER   B 2 42  ? -3.05704  -11.90001 -20.30238 1.000 30.39153 ? 1094 SER   B CA   1 
ATOM   2501 C  C    . SER   B 2 42  ? -3.62588  -13.31209 -20.21268 1.000 27.45725 ? 1094 SER   B C    1 
ATOM   2502 O  O    . SER   B 2 42  ? -2.88177  -14.27404 -20.01082 1.000 27.81941 ? 1094 SER   B O    1 
ATOM   2503 C  CB   . SER   B 2 42  ? -2.29200  -11.70267 -21.61130 1.000 27.87769 ? 1094 SER   B CB   1 
ATOM   2504 O  OG   . SER   B 2 42  ? -3.12391  -11.89755 -22.73839 1.000 29.14295 ? 1094 SER   B OG   1 
ATOM   2505 N  N    . GLY   B 2 43  ? -4.94185  -13.44023 -20.35878 1.000 29.21371 ? 1095 GLY   B N    1 
ATOM   2506 C  CA   . GLY   B 2 43  ? -5.58071  -14.71836 -20.08405 1.000 29.21346 ? 1095 GLY   B CA   1 
ATOM   2507 C  C    . GLY   B 2 43  ? -6.34257  -15.37123 -21.22422 1.000 26.54240 ? 1095 GLY   B C    1 
ATOM   2508 O  O    . GLY   B 2 43  ? -7.30050  -16.10540 -20.97241 1.000 26.98807 ? 1095 GLY   B O    1 
ATOM   2509 N  N    . PHE   B 2 44  ? -5.96053  -15.11495 -22.47315 1.000 22.97031 ? 1096 PHE   B N    1 
ATOM   2510 C  CA   . PHE   B 2 44  ? -6.54438  -15.86581 -23.58332 1.000 21.02122 ? 1096 PHE   B CA   1 
ATOM   2511 C  C    . PHE   B 2 44  ? -6.30121  -17.35982 -23.37959 1.000 21.63257 ? 1096 PHE   B C    1 
ATOM   2512 O  O    . PHE   B 2 44  ? -5.19118  -17.77075 -23.03761 1.000 22.81254 ? 1096 PHE   B O    1 
ATOM   2513 C  CB   . PHE   B 2 44  ? -5.92236  -15.44748 -24.91521 1.000 21.18318 ? 1096 PHE   B CB   1 
ATOM   2514 C  CG   . PHE   B 2 44  ? -6.18151  -14.02544 -25.31595 1.000 26.88871 ? 1096 PHE   B CG   1 
ATOM   2515 C  CD1  . PHE   B 2 44  ? -7.38560  -13.40464 -25.02890 1.000 26.66421 ? 1096 PHE   B CD1  1 
ATOM   2516 C  CD2  . PHE   B 2 44  ? -5.21756  -13.32219 -26.02377 1.000 26.59504 ? 1096 PHE   B CD2  1 
ATOM   2517 C  CE1  . PHE   B 2 44  ? -7.61874  -12.08959 -25.42867 1.000 28.73976 ? 1096 PHE   B CE1  1 
ATOM   2518 C  CE2  . PHE   B 2 44  ? -5.43870  -12.00614 -26.42253 1.000 23.89210 ? 1096 PHE   B CE2  1 
ATOM   2519 C  CZ   . PHE   B 2 44  ? -6.63279  -11.39334 -26.12548 1.000 25.28071 ? 1096 PHE   B CZ   1 
ATOM   2520 N  N    . THR   B 2 45  ? -7.34010  -18.17891 -23.59780 1.000 20.18115 ? 1097 THR   B N    1 
ATOM   2521 C  CA   . THR   B 2 45  ? -7.21493  -19.63491 -23.51007 1.000 22.05113 ? 1097 THR   B CA   1 
ATOM   2522 C  C    . THR   B 2 45  ? -7.58877  -20.38271 -24.78123 1.000 21.99613 ? 1097 THR   B C    1 
ATOM   2523 O  O    . THR   B 2 45  ? -7.09462  -21.49461 -24.99041 1.000 24.82866 ? 1097 THR   B O    1 
ATOM   2524 C  CB   . THR   B 2 45  ? -8.08292  -20.19423 -22.36722 1.000 22.91647 ? 1097 THR   B CB   1 
ATOM   2525 O  OG1  . THR   B 2 45  ? -9.42397  -19.70937 -22.51120 1.000 24.96798 ? 1097 THR   B OG1  1 
ATOM   2526 C  CG2  . THR   B 2 45  ? -7.53105  -19.75741 -21.02811 1.000 22.31672 ? 1097 THR   B CG2  1 
ATOM   2527 N  N    . CYS   B 2 46  ? -8.45579  -19.82666 -25.62217 1.000 22.53217 ? 1098 CYS   B N    1 
ATOM   2528 C  CA   . CYS   B 2 46  ? -8.92464  -20.52649 -26.80933 1.000 24.54593 ? 1098 CYS   B CA   1 
ATOM   2529 C  C    . CYS   B 2 46  ? -9.43671  -19.49437 -27.80216 1.000 22.78535 ? 1098 CYS   B C    1 
ATOM   2530 O  O    . CYS   B 2 46  ? -9.68087  -18.34547 -27.43696 1.000 25.69838 ? 1098 CYS   B O    1 
ATOM   2531 C  CB   . CYS   B 2 46  ? -10.01653 -21.54569 -26.45058 1.000 29.03408 ? 1098 CYS   B CB   1 
ATOM   2532 S  SG   . CYS   B 2 46  ? -11.42567 -20.82203 -25.55952 1.000 29.26056 ? 1098 CYS   B SG   1 
ATOM   2533 N  N    . CYS   B 2 47  ? -9.60159  -19.90615 -29.06325 1.000 25.34102 ? 1099 CYS   B N    1 
ATOM   2534 C  CA   . CYS   B 2 47  ? -9.98166  -18.92100 -30.07709 1.000 25.86355 ? 1099 CYS   B CA   1 
ATOM   2535 C  C    . CYS   B 2 47  ? -10.63251 -19.59086 -31.27825 1.000 28.28125 ? 1099 CYS   B C    1 
ATOM   2536 O  O    . CYS   B 2 47  ? -10.45135 -20.78379 -31.53446 1.000 24.63061 ? 1099 CYS   B O    1 
ATOM   2537 C  CB   . CYS   B 2 47  ? -8.76473  -18.10177 -30.53286 1.000 25.93889 ? 1099 CYS   B CB   1 
ATOM   2538 S  SG   . CYS   B 2 47  ? -7.49157  -19.14149 -31.21699 1.000 29.07231 ? 1099 CYS   B SG   1 
ATOM   2539 N  N    . ALA   B 2 48  ? -11.38557 -18.77981 -32.02213 1.000 26.27819 ? 1100 ALA   B N    1 
ATOM   2540 C  CA   . ALA   B 2 48  ? -12.01045 -19.16465 -33.27924 1.000 31.56857 ? 1100 ALA   B CA   1 
ATOM   2541 C  C    . ALA   B 2 48  ? -12.31657 -17.88454 -34.04602 1.000 29.11125 ? 1100 ALA   B C    1 
ATOM   2542 O  O    . ALA   B 2 48  ? -12.68572 -16.87370 -33.44285 1.000 26.34283 ? 1100 ALA   B O    1 
ATOM   2543 C  CB   . ALA   B 2 48  ? -13.29837 -19.97485 -33.05246 1.000 28.49541 ? 1100 ALA   B CB   1 
ATOM   2544 N  N    . PHE   B 2 49  ? -12.14449 -17.91927 -35.36501 1.000 25.46942 ? 1101 PHE   B N    1 
ATOM   2545 C  CA   . PHE   B 2 49  ? -12.50659 -16.75416 -36.15681 1.000 31.98662 ? 1101 PHE   B CA   1 
ATOM   2546 C  C    . PHE   B 2 49  ? -14.01261 -16.58835 -36.13986 1.000 32.67353 ? 1101 PHE   B C    1 
ATOM   2547 O  O    . PHE   B 2 49  ? -14.75949 -17.56543 -36.19909 1.000 30.84268 ? 1101 PHE   B O    1 
ATOM   2548 C  CB   . PHE   B 2 49  ? -12.01750 -16.88283 -37.59881 1.000 29.78673 ? 1101 PHE   B CB   1 
ATOM   2549 C  CG   . PHE   B 2 49  ? -10.54051 -16.70062 -37.75070 1.000 30.99033 ? 1101 PHE   B CG   1 
ATOM   2550 C  CD1  . PHE   B 2 49  ? -10.00265 -15.44052 -37.96243 1.000 30.09110 ? 1101 PHE   B CD1  1 
ATOM   2551 C  CD2  . PHE   B 2 49  ? -9.68238  -17.78853 -37.66285 1.000 27.96965 ? 1101 PHE   B CD2  1 
ATOM   2552 C  CE1  . PHE   B 2 49  ? -8.62867  -15.27432 -38.10732 1.000 28.39160 ? 1101 PHE   B CE1  1 
ATOM   2553 C  CE2  . PHE   B 2 49  ? -8.31339  -17.63434 -37.80975 1.000 33.47627 ? 1101 PHE   B CE2  1 
ATOM   2554 C  CZ   . PHE   B 2 49  ? -7.78554  -16.37423 -38.02548 1.000 33.51808 ? 1101 PHE   B CZ   1 
ATOM   2555 N  N    . SER   B 2 50  ? -14.46377 -15.34842 -36.03565 1.000 31.58275 ? 1102 SER   B N    1 
ATOM   2556 C  CA   . SER   B 2 50  ? -15.89379 -15.13958 -36.15769 1.000 38.73236 ? 1102 SER   B CA   1 
ATOM   2557 C  C    . SER   B 2 50  ? -16.26973 -14.98934 -37.62768 1.000 39.73211 ? 1102 SER   B C    1 
ATOM   2558 O  O    . SER   B 2 50  ? -15.41569 -14.86907 -38.50861 1.000 37.77213 ? 1102 SER   B O    1 
ATOM   2559 C  CB   . SER   B 2 50  ? -16.34298 -13.92178 -35.35549 1.000 43.25087 ? 1102 SER   B CB   1 
ATOM   2560 O  OG   . SER   B 2 50  ? -16.05709 -12.72462 -36.04124 1.000 41.94824 ? 1102 SER   B OG   1 
ATOM   2561 N  N    . ALA   B 2 51  ? -17.57871 -15.01045 -37.88376 1.000 43.80157 ? 1103 ALA   B N    1 
ATOM   2562 C  CA   . ALA   B 2 51  ? -18.07066 -14.82026 -39.24275 1.000 41.82150 ? 1103 ALA   B CA   1 
ATOM   2563 C  C    . ALA   B 2 51  ? -17.73980 -13.43012 -39.76347 1.000 45.27438 ? 1103 ALA   B C    1 
ATOM   2564 O  O    . ALA   B 2 51  ? -17.64676 -13.22888 -40.97843 1.000 43.83493 ? 1103 ALA   B O    1 
ATOM   2565 C  CB   . ALA   B 2 51  ? -19.57863 -15.05843 -39.29388 1.000 41.85722 ? 1103 ALA   B CB   1 
ATOM   2566 N  N    . ARG   B 2 52  ? -17.57397 -12.46427 -38.86728 1.000 46.14194 ? 1104 ARG   B N    1 
ATOM   2567 C  CA   . ARG   B 2 52  ? -17.15611 -11.11315 -39.23300 1.000 49.94171 ? 1104 ARG   B CA   1 
ATOM   2568 C  C    . ARG   B 2 52  ? -15.64710 -11.13592 -39.44392 1.000 47.49227 ? 1104 ARG   B C    1 
ATOM   2569 O  O    . ARG   B 2 52  ? -14.86415 -11.09301 -38.48987 1.000 47.81801 ? 1104 ARG   B O    1 
ATOM   2570 C  CB   . ARG   B 2 52  ? -17.57329 -10.12440 -38.15084 1.000 50.57903 ? 1104 ARG   B CB   1 
ATOM   2571 C  CG   . ARG   B 2 52  ? -17.24745 -8.67431  -38.43954 1.000 56.89439 ? 1104 ARG   B CG   1 
ATOM   2572 C  CD   . ARG   B 2 52  ? -18.38559 -7.77754  -37.97744 1.000 61.67726 ? 1104 ARG   B CD   1 
ATOM   2573 N  NE   . ARG   B 2 52  ? -17.92077 -6.47056  -37.52616 1.000 62.29793 ? 1104 ARG   B NE   1 
ATOM   2574 C  CZ   . ARG   B 2 52  ? -17.85388 -6.09680  -36.25309 1.000 67.40710 ? 1104 ARG   B CZ   1 
ATOM   2575 N  NH1  . ARG   B 2 52  ? -18.22384 -6.90803  -35.27226 1.000 62.48954 ? 1104 ARG   B NH1  1 
ATOM   2576 N  NH2  . ARG   B 2 52  ? -17.41405 -4.87380  -35.95683 1.000 61.91483 ? 1104 ARG   B NH2  1 
ATOM   2577 N  N    . GLU   B 2 53  ? -15.22302 -11.22564 -40.69792 1.000 50.81940 ? 1105 GLU   B N    1 
ATOM   2578 C  CA   . GLU   B 2 53  ? -13.79998 -11.38341 -40.94987 1.000 56.20510 ? 1105 GLU   B CA   1 
ATOM   2579 C  C    . GLU   B 2 53  ? -13.03116 -10.18243 -40.39660 1.000 54.11096 ? 1105 GLU   B C    1 
ATOM   2580 O  O    . GLU   B 2 53  ? -13.56130 -9.07151  -40.28042 1.000 49.70337 ? 1105 GLU   B O    1 
ATOM   2581 C  CB   . GLU   B 2 53  ? -13.54188 -11.58010 -42.44489 1.000 68.49719 ? 1105 GLU   B CB   1 
ATOM   2582 C  CG   . GLU   B 2 53  ? -13.07299 -10.35190 -43.19163 1.000 63.44146 ? 1105 GLU   B CG   1 
ATOM   2583 C  CD   . GLU   B 2 53  ? -12.46987 -10.71858 -44.53667 1.000 78.58520 ? 1105 GLU   B CD   1 
ATOM   2584 O  OE1  . GLU   B 2 53  ? -11.26883 -11.07142 -44.57067 1.000 75.72934 ? 1105 GLU   B OE1  1 
ATOM   2585 O  OE2  . GLU   B 2 53  ? -13.20282 -10.68447 -45.54970 1.000 82.19263 ? 1105 GLU   B OE2  1 
ATOM   2586 N  N    . ARG   B 2 54  ? -11.77515 -10.43134 -40.02758 1.000 45.25809 ? 1106 ARG   B N    1 
ATOM   2587 C  CA   . ARG   B 2 54  ? -10.86130 -9.54337  -39.31236 1.000 41.00632 ? 1106 ARG   B CA   1 
ATOM   2588 C  C    . ARG   B 2 54  ? -11.04637 -9.64467  -37.80039 1.000 38.33716 ? 1106 ARG   B C    1 
ATOM   2589 O  O    . ARG   B 2 54  ? -10.23448 -9.08972  -37.05524 1.000 34.84737 ? 1106 ARG   B O    1 
ATOM   2590 C  CB   . ARG   B 2 54  ? -10.96845 -8.06730  -39.74309 1.000 50.88914 ? 1106 ARG   B CB   1 
ATOM   2591 C  CG   . ARG   B 2 54  ? -10.29842 -7.76196  -41.10599 1.000 61.90733 ? 1106 ARG   B CG   1 
ATOM   2592 C  CD   . ARG   B 2 54  ? -10.30058 -6.26189  -41.47671 1.000 58.18943 ? 1106 ARG   B CD   1 
ATOM   2593 N  NE   . ARG   B 2 54  ? -9.02267  -5.60178  -41.22152 1.000 56.60650 ? 1106 ARG   B NE   1 
ATOM   2594 C  CZ   . ARG   B 2 54  ? -7.96462  -5.65750  -42.02447 1.000 58.77938 ? 1106 ARG   B CZ   1 
ATOM   2595 N  NH1  . ARG   B 2 54  ? -7.98548  -6.34929  -43.15260 1.000 58.53316 ? 1106 ARG   B NH1  1 
ATOM   2596 N  NH2  . ARG   B 2 54  ? -6.84972  -5.01143  -41.68129 1.000 56.16380 ? 1106 ARG   B NH2  1 
ATOM   2597 N  N    . PHE   B 2 55  ? -12.06331 -10.36489 -37.32158 1.000 31.37188 ? 1107 PHE   B N    1 
ATOM   2598 C  CA   . PHE   B 2 55  ? -12.31437 -10.49219 -35.89462 1.000 34.26552 ? 1107 PHE   B CA   1 
ATOM   2599 C  C    . PHE   B 2 55  ? -12.16622 -11.93426 -35.43688 1.000 34.57683 ? 1107 PHE   B C    1 
ATOM   2600 O  O    . PHE   B 2 55  ? -12.52506 -12.87617 -36.15308 1.000 32.24520 ? 1107 PHE   B O    1 
ATOM   2601 C  CB   . PHE   B 2 55  ? -13.69045 -9.94542  -35.54359 1.000 34.28380 ? 1107 PHE   B CB   1 
ATOM   2602 C  CG   . PHE   B 2 55  ? -13.79062 -8.46639  -35.76232 1.000 34.68267 ? 1107 PHE   B CG   1 
ATOM   2603 C  CD1  . PHE   B 2 55  ? -13.33878 -7.58352  -34.79913 1.000 37.90495 ? 1107 PHE   B CD1  1 
ATOM   2604 C  CD2  . PHE   B 2 55  ? -14.26062 -7.96022  -36.96025 1.000 42.65700 ? 1107 PHE   B CD2  1 
ATOM   2605 C  CE1  . PHE   B 2 55  ? -13.40194 -6.21549  -35.00487 1.000 43.81110 ? 1107 PHE   B CE1  1 
ATOM   2606 C  CE2  . PHE   B 2 55  ? -14.32377 -6.59719  -37.17299 1.000 47.79932 ? 1107 PHE   B CE2  1 
ATOM   2607 C  CZ   . PHE   B 2 55  ? -13.89793 -5.72533  -36.19480 1.000 46.02377 ? 1107 PHE   B CZ   1 
ATOM   2608 N  N    . LEU   B 2 56  ? -11.59526 -12.08441 -34.24488 1.000 29.26662 ? 1108 LEU   B N    1 
ATOM   2609 C  CA   . LEU   B 2 56  ? -11.35814 -13.36850 -33.60811 1.000 30.14187 ? 1108 LEU   B CA   1 
ATOM   2610 C  C    . LEU   B 2 56  ? -12.09621 -13.38185 -32.27615 1.000 27.90524 ? 1108 LEU   B C    1 
ATOM   2611 O  O    . LEU   B 2 56  ? -12.08537 -12.38398 -31.54896 1.000 28.06681 ? 1108 LEU   B O    1 
ATOM   2612 C  CB   . LEU   B 2 56  ? -9.85813  -13.59036 -33.38207 1.000 27.70987 ? 1108 LEU   B CB   1 
ATOM   2613 C  CG   . LEU   B 2 56  ? -9.39599  -14.95041 -32.86630 1.000 26.89396 ? 1108 LEU   B CG   1 
ATOM   2614 C  CD1  . LEU   B 2 56  ? -9.54480  -15.98721 -33.99051 1.000 28.42879 ? 1108 LEU   B CD1  1 
ATOM   2615 C  CD2  . LEU   B 2 56  ? -7.95303  -14.86933 -32.35821 1.000 24.98145 ? 1108 LEU   B CD2  1 
ATOM   2616 N  N    . MET   B 2 57  ? -12.74809 -14.49698 -31.96340 1.000 24.60182 ? 1109 MET   B N    1 
ATOM   2617 C  CA   . MET   B 2 57  ? -13.34714 -14.68531 -30.64547 1.000 25.63968 ? 1109 MET   B CA   1 
ATOM   2618 C  C    . MET   B 2 57  ? -12.35810 -15.43835 -29.76856 1.000 27.32233 ? 1109 MET   B C    1 
ATOM   2619 O  O    . MET   B 2 57  ? -11.79095 -16.44520 -30.20272 1.000 24.47511 ? 1109 MET   B O    1 
ATOM   2620 C  CB   . MET   B 2 57  ? -14.65204 -15.47845 -30.73769 1.000 26.79691 ? 1109 MET   B CB   1 
ATOM   2621 C  CG   . MET   B 2 57  ? -15.66005 -14.94538 -31.73964 1.000 43.70934 ? 1109 MET   B CG   1 
ATOM   2622 S  SD   . MET   B 2 57  ? -16.80086 -16.24742 -32.28195 1.000 47.68755 ? 1109 MET   B SD   1 
ATOM   2623 C  CE   . MET   B 2 57  ? -17.93394 -16.24782 -30.91001 1.000 46.27683 ? 1109 MET   B CE   1 
ATOM   2624 N  N    . LEU   B 2 58  ? -12.15022 -14.96356 -28.54246 1.000 24.98933 ? 1110 LEU   B N    1 
ATOM   2625 C  CA   . LEU   B 2 58  ? -11.23819 -15.64062 -27.63553 1.000 24.85554 ? 1110 LEU   B CA   1 
ATOM   2626 C  C    . LEU   B 2 58  ? -11.91723 -15.88395 -26.29862 1.000 25.16384 ? 1110 LEU   B C    1 
ATOM   2627 O  O    . LEU   B 2 58  ? -12.57937 -14.99614 -25.76048 1.000 26.19916 ? 1110 LEU   B O    1 
ATOM   2628 C  CB   . LEU   B 2 58  ? -9.94730  -14.83850 -27.41331 1.000 26.54898 ? 1110 LEU   B CB   1 
ATOM   2629 C  CG   . LEU   B 2 58  ? -9.17127  -14.47517 -28.68320 1.000 26.08840 ? 1110 LEU   B CG   1 
ATOM   2630 C  CD1  . LEU   B 2 58  ? -9.46643  -13.02813 -29.08694 1.000 25.24306 ? 1110 LEU   B CD1  1 
ATOM   2631 C  CD2  . LEU   B 2 58  ? -7.68126  -14.69702 -28.50316 1.000 23.94816 ? 1110 LEU   B CD2  1 
ATOM   2632 N  N    . GLY   B 2 59  ? -11.73312 -17.08103 -25.75883 1.000 23.49900 ? 1111 GLY   B N    1 
ATOM   2633 C  CA   . GLY   B 2 59  ? -12.10816 -17.33634 -24.38890 1.000 21.52711 ? 1111 GLY   B CA   1 
ATOM   2634 C  C    . GLY   B 2 59  ? -10.97125 -17.00237 -23.45878 1.000 26.71028 ? 1111 GLY   B C    1 
ATOM   2635 O  O    . GLY   B 2 59  ? -9.81023  -16.94916 -23.87170 1.000 26.00978 ? 1111 GLY   B O    1 
ATOM   2636 N  N    . THR   B 2 60  ? -11.30135 -16.76165 -22.19075 1.000 24.99408 ? 1112 THR   B N    1 
ATOM   2637 C  CA   . THR   B 2 60  ? -10.28845 -16.33671 -21.23261 1.000 21.94675 ? 1112 THR   B CA   1 
ATOM   2638 C  C    . THR   B 2 60  ? -10.36942 -17.16796 -19.96377 1.000 26.84674 ? 1112 THR   B C    1 
ATOM   2639 O  O    . THR   B 2 60  ? -11.35835 -17.85213 -19.69496 1.000 24.36093 ? 1112 THR   B O    1 
ATOM   2640 C  CB   . THR   B 2 60  ? -10.43565 -14.85980 -20.85034 1.000 25.16197 ? 1112 THR   B CB   1 
ATOM   2641 O  OG1  . THR   B 2 60  ? -11.47972 -14.74211 -19.88038 1.000 22.47678 ? 1112 THR   B OG1  1 
ATOM   2642 C  CG2  . THR   B 2 60  ? -10.76469 -14.01261 -22.06620 1.000 22.72462 ? 1112 THR   B CG2  1 
ATOM   2643 N  N    . CYS   B 2 61  ? -9.31748  -17.04799 -19.15669 1.000 25.25198 ? 1113 CYS   B N    1 
ATOM   2644 C  CA   . CYS   B 2 61  ? -9.21245  -17.81521 -17.92883 1.000 27.47765 ? 1113 CYS   B CA   1 
ATOM   2645 C  C    . CYS   B 2 61  ? -10.20456 -17.37253 -16.86480 1.000 25.65300 ? 1113 CYS   B C    1 
ATOM   2646 O  O    . CYS   B 2 61  ? -10.32154 -18.05373 -15.84494 1.000 28.62243 ? 1113 CYS   B O    1 
ATOM   2647 C  CB   . CYS   B 2 61  ? -7.79749  -17.72514 -17.37274 1.000 32.16788 ? 1113 CYS   B CB   1 
ATOM   2648 S  SG   . CYS   B 2 61  ? -7.40272  -16.07118 -16.92141 1.000 37.49593 ? 1113 CYS   B SG   1 
ATOM   2649 N  N    . THR   B 2 62  ? -10.93069 -16.27358 -17.06964 1.000 28.06760 ? 1114 THR   B N    1 
ATOM   2650 C  CA   . THR   B 2 62  ? -11.97879 -15.87788 -16.13662 1.000 26.68784 ? 1114 THR   B CA   1 
ATOM   2651 C  C    . THR   B 2 62  ? -13.37472 -16.16895 -16.66975 1.000 29.93718 ? 1114 THR   B C    1 
ATOM   2652 O  O    . THR   B 2 62  ? -14.35182 -15.62517 -16.14770 1.000 30.18804 ? 1114 THR   B O    1 
ATOM   2653 C  CB   . THR   B 2 62  ? -11.87399 -14.39693 -15.79133 1.000 26.98242 ? 1114 THR   B CB   1 
ATOM   2654 O  OG1  . THR   B 2 62  ? -12.02401 -13.62973 -16.98620 1.000 31.77987 ? 1114 THR   B OG1  1 
ATOM   2655 C  CG2  . THR   B 2 62  ? -10.52706 -14.08889 -15.14520 1.000 35.56404 ? 1114 THR   B CG2  1 
ATOM   2656 N  N    . GLY   B 2 63  ? -13.49157 -16.98777 -17.70691 1.000 23.38188 ? 1115 GLY   B N    1 
ATOM   2657 C  CA   . GLY   B 2 63  ? -14.80450 -17.32983 -18.22005 1.000 23.50162 ? 1115 GLY   B CA   1 
ATOM   2658 C  C    . GLY   B 2 63  ? -15.44357 -16.30174 -19.11789 1.000 25.53515 ? 1115 GLY   B C    1 
ATOM   2659 O  O    . GLY   B 2 63  ? -16.64755 -16.38984 -19.38497 1.000 23.33129 ? 1115 GLY   B O    1 
ATOM   2660 N  N    . GLN   B 2 64  ? -14.64066 -15.37955 -19.61267 1.000 26.62744 ? 1116 GLN   B N    1 
ATOM   2661 C  CA   . GLN   B 2 64  ? -15.17773 -14.35644 -20.52750 1.000 24.00251 ? 1116 GLN   B CA   1 
ATOM   2662 C  C    . GLN   B 2 64  ? -14.94861 -14.71514 -21.99756 1.000 22.86254 ? 1116 GLN   B C    1 
ATOM   2663 O  O    . GLN   B 2 64  ? -14.00750 -15.45097 -22.28465 1.000 24.40475 ? 1116 GLN   B O    1 
ATOM   2664 C  CB   . GLN   B 2 64  ? -14.56892 -12.98742 -20.22621 1.000 29.71372 ? 1116 GLN   B CB   1 
ATOM   2665 C  CG   . GLN   B 2 64  ? -14.97606 -12.40873 -18.87813 1.000 37.31303 ? 1116 GLN   B CG   1 
ATOM   2666 C  CD   . GLN   B 2 64  ? -14.30324 -11.08870 -18.57784 1.000 60.96586 ? 1116 GLN   B CD   1 
ATOM   2667 O  OE1  . GLN   B 2 64  ? -13.22225 -10.78047 -19.09072 1.000 58.33264 ? 1116 GLN   B OE1  1 
ATOM   2668 N  NE2  . GLN   B 2 64  ? -14.93638 -10.29594 -17.72572 1.000 75.71524 ? 1116 GLN   B NE2  1 
ATOM   2669 N  N    . LEU   B 2 65  ? -15.83962 -14.25308 -22.85952 1.000 26.17645 ? 1117 LEU   B N    1 
ATOM   2670 C  CA   . LEU   B 2 65  ? -15.70953 -14.36779 -24.30254 1.000 29.86023 ? 1117 LEU   B CA   1 
ATOM   2671 C  C    . LEU   B 2 65  ? -15.44967 -12.96866 -24.84626 1.000 29.44434 ? 1117 LEU   B C    1 
ATOM   2672 O  O    . LEU   B 2 65  ? -16.23979 -12.05380 -24.59513 1.000 25.47438 ? 1117 LEU   B O    1 
ATOM   2673 C  CB   . LEU   B 2 65  ? -16.98242 -14.96984 -24.90172 1.000 28.71860 ? 1117 LEU   B CB   1 
ATOM   2674 C  CG   . LEU   B 2 65  ? -17.02729 -15.39456 -26.37780 1.000 37.71081 ? 1117 LEU   B CG   1 
ATOM   2675 C  CD1  . LEU   B 2 65  ? -17.17338 -14.20940 -27.30259 1.000 38.81797 ? 1117 LEU   B CD1  1 
ATOM   2676 C  CD2  . LEU   B 2 65  ? -15.80017 -16.21634 -26.73589 1.000 29.77441 ? 1117 LEU   B CD2  1 
ATOM   2677 N  N    . LYS   B 2 66  ? -14.33665 -12.78739 -25.55116 1.000 24.89885 ? 1118 LYS   B N    1 
ATOM   2678 C  CA   . LYS   B 2 66  ? -13.97278 -11.46925 -26.05989 1.000 24.92984 ? 1118 LYS   B CA   1 
ATOM   2679 C  C    . LYS   B 2 66  ? -13.79870 -11.51094 -27.57489 1.000 29.40532 ? 1118 LYS   B C    1 
ATOM   2680 O  O    . LYS   B 2 66  ? -13.43054 -12.54079 -28.14707 1.000 29.01726 ? 1118 LYS   B O    1 
ATOM   2681 C  CB   . LYS   B 2 66  ? -12.69388 -10.94822 -25.39273 1.000 26.80192 ? 1118 LYS   B CB   1 
ATOM   2682 C  CG   . LYS   B 2 66  ? -12.85099 -10.70752 -23.90669 1.000 32.79722 ? 1118 LYS   B CG   1 
ATOM   2683 C  CD   . LYS   B 2 66  ? -11.66011 -9.98948  -23.32649 1.000 32.84550 ? 1118 LYS   B CD   1 
ATOM   2684 C  CE   . LYS   B 2 66  ? -11.94324 -9.54379  -21.90142 1.000 36.58317 ? 1118 LYS   B CE   1 
ATOM   2685 N  NZ   . LYS   B 2 66  ? -10.73435 -8.92876  -21.27324 1.000 36.41339 ? 1118 LYS   B NZ   1 
ATOM   2686 N  N    . LEU   B 2 67  ? -14.10380 -10.38786 -28.21370 1.000 28.91151 ? 1119 LEU   B N    1 
ATOM   2687 C  CA   . LEU   B 2 67  ? -13.96774 -10.21457 -29.65366 1.000 29.16101 ? 1119 LEU   B CA   1 
ATOM   2688 C  C    . LEU   B 2 67  ? -12.82485 -9.24538  -29.91041 1.000 28.54120 ? 1119 LEU   B C    1 
ATOM   2689 O  O    . LEU   B 2 67  ? -12.79601 -8.15049  -29.33820 1.000 26.98647 ? 1119 LEU   B O    1 
ATOM   2690 C  CB   . LEU   B 2 67  ? -15.25777 -9.67061  -30.27162 1.000 28.42480 ? 1119 LEU   B CB   1 
ATOM   2691 C  CG   . LEU   B 2 67  ? -16.17761 -10.67759 -30.94686 1.000 46.74352 ? 1119 LEU   B CG   1 
ATOM   2692 C  CD1  . LEU   B 2 67  ? -15.55149 -11.14527 -32.25492 1.000 38.11227 ? 1119 LEU   B CD1  1 
ATOM   2693 C  CD2  . LEU   B 2 67  ? -16.45152 -11.85180 -30.01410 1.000 43.94792 ? 1119 LEU   B CD2  1 
ATOM   2694 N  N    . TYR   B 2 68  ? -11.88875 -9.64711  -30.75944 1.000 26.55157 ? 1120 TYR   B N    1 
ATOM   2695 C  CA   . TYR   B 2 68  ? -10.71783 -8.83391  -31.04322 1.000 26.78978 ? 1120 TYR   B CA   1 
ATOM   2696 C  C    . TYR   B 2 68  ? -10.55577 -8.66861  -32.54718 1.000 29.84003 ? 1120 TYR   B C    1 
ATOM   2697 O  O    . TYR   B 2 68  ? -10.76862 -9.61249  -33.31937 1.000 28.37301 ? 1120 TYR   B O    1 
ATOM   2698 C  CB   . TYR   B 2 68  ? -9.42579  -9.45187  -30.44527 1.000 24.81382 ? 1120 TYR   B CB   1 
ATOM   2699 C  CG   . TYR   B 2 68  ? -9.16992  -9.06811  -29.00918 1.000 28.52468 ? 1120 TYR   B CG   1 
ATOM   2700 C  CD1  . TYR   B 2 68  ? -9.87590  -9.66539  -27.97133 1.000 22.66017 ? 1120 TYR   B CD1  1 
ATOM   2701 C  CD2  . TYR   B 2 68  ? -8.20605  -8.10205  -28.68194 1.000 26.51608 ? 1120 TYR   B CD2  1 
ATOM   2702 C  CE1  . TYR   B 2 68  ? -9.64502  -9.31161  -26.64325 1.000 24.96496 ? 1120 TYR   B CE1  1 
ATOM   2703 C  CE2  . TYR   B 2 68  ? -7.97417  -7.74427  -27.36286 1.000 27.03954 ? 1120 TYR   B CE2  1 
ATOM   2704 C  CZ   . TYR   B 2 68  ? -8.69815  -8.34255  -26.34702 1.000 28.30630 ? 1120 TYR   B CZ   1 
ATOM   2705 O  OH   . TYR   B 2 68  ? -8.46926  -7.98577  -25.03294 1.000 29.36507 ? 1120 TYR   B OH   1 
ATOM   2706 N  N    . ASN   B 2 69  ? -10.18690 -7.45749  -32.94793 1.000 27.69162 ? 1121 ASN   B N    1 
ATOM   2707 C  CA   . ASN   B 2 69  ? -9.63185  -7.23317  -34.27486 1.000 28.99520 ? 1121 ASN   B CA   1 
ATOM   2708 C  C    . ASN   B 2 69  ? -8.25977  -7.88899  -34.33991 1.000 27.78086 ? 1121 ASN   B C    1 
ATOM   2709 O  O    . ASN   B 2 69  ? -7.34486  -7.48501  -33.61078 1.000 28.79319 ? 1121 ASN   B O    1 
ATOM   2710 C  CB   . ASN   B 2 69  ? -9.52602  -5.73110  -34.55157 1.000 29.24782 ? 1121 ASN   B CB   1 
ATOM   2711 C  CG   . ASN   B 2 69  ? -9.10298  -5.43678  -35.97149 1.000 31.78312 ? 1121 ASN   B CG   1 
ATOM   2712 O  OD1  . ASN   B 2 69  ? -8.07489  -5.93057  -36.44053 1.000 27.41089 ? 1121 ASN   B OD1  1 
ATOM   2713 N  ND2  . ASN   B 2 69  ? -9.91304  -4.66175  -36.68039 1.000 33.08802 ? 1121 ASN   B ND2  1 
ATOM   2714 N  N    . VAL   B 2 70  ? -8.10560  -8.90281  -35.20009 1.000 27.87501 ? 1122 VAL   B N    1 
ATOM   2715 C  CA   . VAL   B 2 70  ? -6.84951  -9.65766  -35.17816 1.000 27.27028 ? 1122 VAL   B CA   1 
ATOM   2716 C  C    . VAL   B 2 70  ? -5.67058  -8.86541  -35.71695 1.000 28.56399 ? 1122 VAL   B C    1 
ATOM   2717 O  O    . VAL   B 2 70  ? -4.52355  -9.20733  -35.41695 1.000 30.61171 ? 1122 VAL   B O    1 
ATOM   2718 C  CB   . VAL   B 2 70  ? -6.92931  -10.97552 -35.96842 1.000 31.33034 ? 1122 VAL   B CB   1 
ATOM   2719 C  CG1  . VAL   B 2 70  ? -7.93823  -11.89076 -35.35865 1.000 32.77885 ? 1122 VAL   B CG1  1 
ATOM   2720 C  CG2  . VAL   B 2 70  ? -7.22626  -10.69928 -37.43338 1.000 30.17941 ? 1122 VAL   B CG2  1 
ATOM   2721 N  N    . PHE   B 2 71  ? -5.90266  -7.82429  -36.51377 1.000 31.96994 ? 1123 PHE   B N    1 
ATOM   2722 C  CA   . PHE   B 2 71  ? -4.78772  -7.05905  -37.06056 1.000 29.74651 ? 1123 PHE   B CA   1 
ATOM   2723 C  C    . PHE   B 2 71  ? -4.34091  -5.92617  -36.14532 1.000 31.75120 ? 1123 PHE   B C    1 
ATOM   2724 O  O    . PHE   B 2 71  ? -3.13395  -5.70005  -35.99622 1.000 34.25766 ? 1123 PHE   B O    1 
ATOM   2725 C  CB   . PHE   B 2 71  ? -5.16171  -6.51884  -38.43748 1.000 27.63804 ? 1123 PHE   B CB   1 
ATOM   2726 C  CG   . PHE   B 2 71  ? -5.52653  -7.59970  -39.40270 1.000 32.83167 ? 1123 PHE   B CG   1 
ATOM   2727 C  CD1  . PHE   B 2 71  ? -4.54140  -8.37947  -39.99080 1.000 33.40090 ? 1123 PHE   B CD1  1 
ATOM   2728 C  CD2  . PHE   B 2 71  ? -6.85048  -7.86881  -39.68883 1.000 37.73204 ? 1123 PHE   B CD2  1 
ATOM   2729 C  CE1  . PHE   B 2 71  ? -4.87323  -9.39334  -40.86601 1.000 33.98306 ? 1123 PHE   B CE1  1 
ATOM   2730 C  CE2  . PHE   B 2 71  ? -7.19631  -8.87668  -40.56804 1.000 40.76169 ? 1123 PHE   B CE2  1 
ATOM   2731 C  CZ   . PHE   B 2 71  ? -6.21019  -9.63945  -41.15813 1.000 33.95651 ? 1123 PHE   B CZ   1 
ATOM   2732 N  N    . SER   B 2 72  ? -5.27803  -5.22140  -35.50724 1.000 31.94392 ? 1124 SER   B N    1 
ATOM   2733 C  CA   . SER   B 2 72  ? -4.90121  -4.13053  -34.61301 1.000 31.63493 ? 1124 SER   B CA   1 
ATOM   2734 C  C    . SER   B 2 72  ? -4.66924  -4.57777  -33.17809 1.000 33.64712 ? 1124 SER   B C    1 
ATOM   2735 O  O    . SER   B 2 72  ? -3.93336  -3.90982  -32.44892 1.000 30.83298 ? 1124 SER   B O    1 
ATOM   2736 C  CB   . SER   B 2 72  ? -5.97635  -3.04466  -34.60887 1.000 29.48423 ? 1124 SER   B CB   1 
ATOM   2737 O  OG   . SER   B 2 72  ? -7.16832  -3.52592  -34.00702 1.000 31.17826 ? 1124 SER   B OG   1 
ATOM   2738 N  N    . GLY   B 2 73  ? -5.26312  -5.68992  -32.75633 1.000 29.89853 ? 1125 GLY   B N    1 
ATOM   2739 C  CA   . GLY   B 2 73  ? -5.21815  -6.08218  -31.36340 1.000 25.79154 ? 1125 GLY   B CA   1 
ATOM   2740 C  C    . GLY   B 2 73  ? -6.26728  -5.41847  -30.51133 1.000 26.81225 ? 1125 GLY   B C    1 
ATOM   2741 O  O    . GLY   B 2 73  ? -6.21433  -5.53169  -29.28135 1.000 28.12245 ? 1125 GLY   B O    1 
ATOM   2742 N  N    . GLN   B 2 74  ? -7.21133  -4.71747  -31.12925 1.000 27.43591 ? 1126 GLN   B N    1 
ATOM   2743 C  CA   . GLN   B 2 74  ? -8.22446  -3.97073  -30.40816 1.000 29.38626 ? 1126 GLN   B CA   1 
ATOM   2744 C  C    . GLN   B 2 74  ? -9.32238  -4.90196  -29.90640 1.000 27.28957 ? 1126 GLN   B C    1 
ATOM   2745 O  O    . GLN   B 2 74  ? -9.92424  -5.64188  -30.68757 1.000 28.87389 ? 1126 GLN   B O    1 
ATOM   2746 C  CB   . GLN   B 2 74  ? -8.83754  -2.91163  -31.32500 1.000 30.14141 ? 1126 GLN   B CB   1 
ATOM   2747 C  CG   . GLN   B 2 74  ? -9.92967  -2.11889  -30.66391 1.000 38.56630 ? 1126 GLN   B CG   1 
ATOM   2748 C  CD   . GLN   B 2 74  ? -9.38484  -1.21802  -29.58971 1.000 43.01345 ? 1126 GLN   B CD   1 
ATOM   2749 O  OE1  . GLN   B 2 74  ? -8.68494  -0.24588  -29.88649 1.000 48.00538 ? 1126 GLN   B OE1  1 
ATOM   2750 N  NE2  . GLN   B 2 74  ? -9.68187  -1.53930  -28.32678 1.000 42.18158 ? 1126 GLN   B NE2  1 
ATOM   2751 N  N    . GLU   B 2 75  ? -9.60445  -4.83623  -28.61140 1.000 29.54684 ? 1127 GLU   B N    1 
ATOM   2752 C  CA   . GLU   B 2 75  ? -10.76440 -5.53048  -28.06760 1.000 35.63118 ? 1127 GLU   B CA   1 
ATOM   2753 C  C    . GLU   B 2 75  ? -12.04246 -4.82055  -28.50353 1.000 32.24418 ? 1127 GLU   B C    1 
ATOM   2754 O  O    . GLU   B 2 75  ? -12.18462 -3.60960  -28.32231 1.000 37.10498 ? 1127 GLU   B O    1 
ATOM   2755 C  CB   . GLU   B 2 75  ? -10.67047 -5.59675  -26.54860 1.000 29.29086 ? 1127 GLU   B CB   1 
ATOM   2756 C  CG   . GLU   B 2 75  ? -11.84042 -6.30902  -25.90380 1.000 31.21616 ? 1127 GLU   B CG   1 
ATOM   2757 C  CD   . GLU   B 2 75  ? -11.69149 -6.41528  -24.40881 1.000 32.90781 ? 1127 GLU   B CD   1 
ATOM   2758 O  OE1  . GLU   B 2 75  ? -10.62446 -6.88024  -23.94284 1.000 31.35509 ? 1127 GLU   B OE1  1 
ATOM   2759 O  OE2  . GLU   B 2 75  ? -12.64757 -6.03653  -23.69980 1.000 37.09574 ? 1127 GLU   B OE2  1 
ATOM   2760 N  N    . GLU   B 2 76  ? -12.96334 -5.56755  -29.09872 1.000 30.69914 ? 1128 GLU   B N    1 
ATOM   2761 C  CA   . GLU   B 2 76  ? -14.20338 -4.99861  -29.60268 1.000 33.06371 ? 1128 GLU   B CA   1 
ATOM   2762 C  C    . GLU   B 2 76  ? -15.40040 -5.25492  -28.70780 1.000 38.16274 ? 1128 GLU   B C    1 
ATOM   2763 O  O    . GLU   B 2 76  ? -16.35349 -4.47603  -28.73570 1.000 40.86196 ? 1128 GLU   B O    1 
ATOM   2764 C  CB   . GLU   B 2 76  ? -14.52024 -5.55638  -30.99181 1.000 33.65650 ? 1128 GLU   B CB   1 
ATOM   2765 C  CG   . GLU   B 2 76  ? -13.64724 -5.00807  -32.09966 1.000 46.62289 ? 1128 GLU   B CG   1 
ATOM   2766 C  CD   . GLU   B 2 76  ? -13.93540 -3.56104  -32.41640 1.000 46.48903 ? 1128 GLU   B CD   1 
ATOM   2767 O  OE1  . GLU   B 2 76  ? -15.11143 -3.24313  -32.70940 1.000 57.11884 ? 1128 GLU   B OE1  1 
ATOM   2768 O  OE2  . GLU   B 2 76  ? -12.98050 -2.75194  -32.36719 1.000 52.54140 ? 1128 GLU   B OE2  1 
ATOM   2769 N  N    . ALA   B 2 77  ? -15.39331 -6.33007  -27.92900 1.000 32.05537 ? 1129 ALA   B N    1 
ATOM   2770 C  CA   . ALA   B 2 77  ? -16.54731 -6.67636  -27.11113 1.000 32.68343 ? 1129 ALA   B CA   1 
ATOM   2771 C  C    . ALA   B 2 77  ? -16.09624 -7.70450  -26.09630 1.000 31.41763 ? 1129 ALA   B C    1 
ATOM   2772 O  O    . ALA   B 2 77  ? -15.10814 -8.41534  -26.30938 1.000 29.56225 ? 1129 ALA   B O    1 
ATOM   2773 C  CB   . ALA   B 2 77  ? -17.70820 -7.22335  -27.95329 1.000 27.90076 ? 1129 ALA   B CB   1 
ATOM   2774 N  N    . SER   B 2 78  ? -16.83129 -7.77380  -24.99435 1.000 30.84156 ? 1130 SER   B N    1 
ATOM   2775 C  CA   . SER   B 2 78  ? -16.54324 -8.71097  -23.92151 1.000 31.54742 ? 1130 SER   B CA   1 
ATOM   2776 C  C    . SER   B 2 78  ? -17.85821 -9.19424  -23.33568 1.000 33.33383 ? 1130 SER   B C    1 
ATOM   2777 O  O    . SER   B 2 78  ? -18.76832 -8.39239  -23.12357 1.000 32.42699 ? 1130 SER   B O    1 
ATOM   2778 C  CB   . SER   B 2 78  ? -15.69237 -8.06207  -22.83034 1.000 30.02472 ? 1130 SER   B CB   1 
ATOM   2779 O  OG   . SER   B 2 78  ? -15.47432 -8.98424  -21.78551 1.000 33.31182 ? 1130 SER   B OG   1 
ATOM   2780 N  N    . TYR   B 2 79  ? -17.96406 -10.50229 -23.10293 1.000 28.01155 ? 1131 TYR   B N    1 
ATOM   2781 C  CA   . TYR   B 2 79  ? -19.17202 -11.10255 -22.54811 1.000 26.97515 ? 1131 TYR   B CA   1 
ATOM   2782 C  C    . TYR   B 2 79  ? -18.77796 -12.09270 -21.46327 1.000 29.29333 ? 1131 TYR   B C    1 
ATOM   2783 O  O    . TYR   B 2 79  ? -17.75087 -12.77256 -21.57535 1.000 31.17837 ? 1131 TYR   B O    1 
ATOM   2784 C  CB   . TYR   B 2 79  ? -20.00587 -11.81545 -23.62229 1.000 25.97955 ? 1131 TYR   B CB   1 
ATOM   2785 C  CG   . TYR   B 2 79  ? -20.26391 -10.99224 -24.86615 1.000 34.44395 ? 1131 TYR   B CG   1 
ATOM   2786 C  CD1  . TYR   B 2 79  ? -21.32101 -10.08936 -24.92103 1.000 37.63084 ? 1131 TYR   B CD1  1 
ATOM   2787 C  CD2  . TYR   B 2 79  ? -19.45183 -11.11993 -25.99213 1.000 38.93059 ? 1131 TYR   B CD2  1 
ATOM   2788 C  CE1  . TYR   B 2 79  ? -21.56004 -9.33117  -26.06790 1.000 43.08548 ? 1131 TYR   B CE1  1 
ATOM   2789 C  CE2  . TYR   B 2 79  ? -19.67986 -10.36774 -27.13200 1.000 34.11560 ? 1131 TYR   B CE2  1 
ATOM   2790 C  CZ   . TYR   B 2 79  ? -20.73697 -9.47886  -27.16689 1.000 39.96438 ? 1131 TYR   B CZ   1 
ATOM   2791 O  OH   . TYR   B 2 79  ? -20.96900 -8.73668  -28.30276 1.000 45.88008 ? 1131 TYR   B OH   1 
ATOM   2792 N  N    . ASN   B 2 80  ? -19.67200 -12.18500 -20.46234 1.000 29.46826 ? 1132 ASN   B N    1 
ATOM   2793 C  CA   . ASN   B 2 80  ? -19.53095 -13.12020 -19.31351 1.000 30.14363 ? 1132 ASN   B CA   1 
ATOM   2794 C  C    . ASN   B 2 80  ? -20.22877 -14.43123 -19.61779 1.000 33.62012 ? 1132 ASN   B C    1 
ATOM   2795 O  O    . ASN   B 2 80  ? -21.46077 -14.46239 -19.58687 1.000 36.36142 ? 1132 ASN   B O    1 
ATOM   2796 C  CB   . ASN   B 2 80  ? -20.03409 -12.52751 -18.00442 1.000 36.12554 ? 1132 ASN   B CB   1 
ATOM   2797 C  CG   . ASN   B 2 80  ? -19.10725 -11.44149 -17.51217 1.000 52.11046 ? 1132 ASN   B CG   1 
ATOM   2798 O  OD1  . ASN   B 2 80  ? -17.92424 -11.41428 -17.87710 1.000 57.07737 ? 1132 ASN   B OD1  1 
ATOM   2799 N  ND2  . ASN   B 2 80  ? -19.61041 -10.55071 -16.67103 1.000 63.69876 ? 1132 ASN   B ND2  1 
ATOM   2800 N  N    . CYS   B 2 81  ? -19.43463 -15.45108 -19.88994 1.000 24.41024 ? 1133 CYS   B N    1 
ATOM   2801 C  CA   . CYS   B 2 81  ? -20.08946 -16.69909 -20.26421 1.000 23.87227 ? 1133 CYS   B CA   1 
ATOM   2802 C  C    . CYS   B 2 81  ? -20.08239 -17.75130 -19.16641 1.000 22.05796 ? 1133 CYS   B C    1 
ATOM   2803 O  O    . CYS   B 2 81  ? -21.05931 -18.49144 -19.03861 1.000 23.13834 ? 1133 CYS   B O    1 
ATOM   2804 C  CB   . CYS   B 2 81  ? -19.44032 -17.27977 -21.52329 1.000 22.89871 ? 1133 CYS   B CB   1 
ATOM   2805 S  SG   . CYS   B 2 81  ? -19.75537 -16.26354 -22.97311 1.000 27.11369 ? 1133 CYS   B SG   1 
ATOM   2806 N  N    . HIS   B 2 82  ? -19.00542 -17.86431 -18.39538 1.000 23.07896 ? 1134 HIS   B N    1 
ATOM   2807 C  CA   . HIS   B 2 82  ? -18.87834 -18.94848 -17.43057 1.000 25.38425 ? 1134 HIS   B CA   1 
ATOM   2808 C  C    . HIS   B 2 82  ? -18.21347 -18.43664 -16.16244 1.000 25.17067 ? 1134 HIS   B C    1 
ATOM   2809 O  O    . HIS   B 2 82  ? -17.54760 -17.39956 -16.15621 1.000 25.20628 ? 1134 HIS   B O    1 
ATOM   2810 C  CB   . HIS   B 2 82  ? -18.06617 -20.12927 -17.99775 1.000 20.91807 ? 1134 HIS   B CB   1 
ATOM   2811 C  CG   . HIS   B 2 82  ? -18.76502 -20.87515 -19.09993 1.000 19.71680 ? 1134 HIS   B CG   1 
ATOM   2812 N  ND1  . HIS   B 2 82  ? -19.66190 -21.89530 -18.85817 1.000 19.41654 ? 1134 HIS   B ND1  1 
ATOM   2813 C  CD2  . HIS   B 2 82  ? -18.69496 -20.75089 -20.44690 1.000 20.07153 ? 1134 HIS   B CD2  1 
ATOM   2814 C  CE1  . HIS   B 2 82  ? -20.11578 -22.36414 -20.00829 1.000 22.04203 ? 1134 HIS   B CE1  1 
ATOM   2815 N  NE2  . HIS   B 2 82  ? -19.53681 -21.69189 -20.98813 1.000 19.78387 ? 1134 HIS   B NE2  1 
ATOM   2816 N  N    . ASN   B 2 83  ? -18.39544 -19.19586 -15.08459 1.000 25.73576 ? 1135 ASN   B N    1 
ATOM   2817 C  CA   . ASN   B 2 83  ? -17.79355 -18.89103 -13.79350 1.000 27.14948 ? 1135 ASN   B CA   1 
ATOM   2818 C  C    . ASN   B 2 83  ? -16.46947 -19.60891 -13.58757 1.000 29.26646 ? 1135 ASN   B C    1 
ATOM   2819 O  O    . ASN   B 2 83  ? -16.02051 -19.76007 -12.44657 1.000 27.38434 ? 1135 ASN   B O    1 
ATOM   2820 C  CB   . ASN   B 2 83  ? -18.76956 -19.24636 -12.67362 1.000 25.06026 ? 1135 ASN   B CB   1 
ATOM   2821 C  CG   . ASN   B 2 83  ? -19.98167 -18.35751 -12.67952 1.000 35.67066 ? 1135 ASN   B CG   1 
ATOM   2822 O  OD1  . ASN   B 2 83  ? -19.91179 -17.20742 -13.10430 1.000 29.59119 ? 1135 ASN   B OD1  1 
ATOM   2823 N  ND2  . ASN   B 2 83  ? -21.10863 -18.88174 -12.21068 1.000 34.95125 ? 1135 ASN   B ND2  1 
ATOM   2824 N  N    . SER   B 2 84  ? -15.84136 -20.05863 -14.66262 1.000 23.83468 ? 1136 SER   B N    1 
ATOM   2825 C  CA   . SER   B 2 84  ? -14.51329 -20.64248 -14.59666 1.000 25.06266 ? 1136 SER   B CA   1 
ATOM   2826 C  C    . SER   B 2 84  ? -13.92823 -20.50915 -15.98760 1.000 24.39314 ? 1136 SER   B C    1 
ATOM   2827 O  O    . SER   B 2 84  ? -14.61323 -20.09705 -16.92256 1.000 23.40595 ? 1136 SER   B O    1 
ATOM   2828 C  CB   . SER   B 2 84  ? -14.55414 -22.10158 -14.11593 1.000 24.80681 ? 1136 SER   B CB   1 
ATOM   2829 O  OG   . SER   B 2 84  ? -15.42200 -22.86953 -14.93813 1.000 23.59346 ? 1136 SER   B OG   1 
ATOM   2830 N  N    . ALA   B 2 85  ? -12.64918 -20.84097 -16.11159 1.000 21.17197 ? 1137 ALA   B N    1 
ATOM   2831 C  CA   . ALA   B 2 85  ? -11.93714 -20.59565 -17.35751 1.000 22.46482 ? 1137 ALA   B CA   1 
ATOM   2832 C  C    . ALA   B 2 85  ? -12.60199 -21.29950 -18.53968 1.000 24.70209 ? 1137 ALA   B C    1 
ATOM   2833 O  O    . ALA   B 2 85  ? -13.02286 -22.45457 -18.44692 1.000 21.29463 ? 1137 ALA   B O    1 
ATOM   2834 C  CB   . ALA   B 2 85  ? -10.48709 -21.06049 -17.23552 1.000 25.31127 ? 1137 ALA   B CB   1 
ATOM   2835 N  N    . ILE   B 2 86  ? -12.70402 -20.58930 -19.66155 1.000 24.54169 ? 1138 ILE   B N    1 
ATOM   2836 C  CA   A ILE   B 2 86  ? -13.14387 -21.23313 -20.88969 0.543 22.97018 ? 1138 ILE   B CA   1 
ATOM   2837 C  CA   B ILE   B 2 86  ? -13.13788 -21.21812 -20.90369 0.457 22.97737 ? 1138 ILE   B CA   1 
ATOM   2838 C  C    . ILE   B 2 86  ? -12.03374 -22.14089 -21.39380 1.000 27.15863 ? 1138 ILE   B C    1 
ATOM   2839 O  O    . ILE   B 2 86  ? -10.85478 -21.75674 -21.42567 1.000 26.72191 ? 1138 ILE   B O    1 
ATOM   2840 C  CB   A ILE   B 2 86  ? -13.55094 -20.18898 -21.93952 0.543 23.21526 ? 1138 ILE   B CB   1 
ATOM   2841 C  CB   B ILE   B 2 86  ? -13.47895 -20.15896 -21.96051 0.457 23.20175 ? 1138 ILE   B CB   1 
ATOM   2842 C  CG1  A ILE   B 2 86  ? -14.73407 -19.36622 -21.41743 0.543 25.90557 ? 1138 ILE   B CG1  1 
ATOM   2843 C  CG1  B ILE   B 2 86  ? -14.34212 -19.05218 -21.35335 0.457 26.06308 ? 1138 ILE   B CG1  1 
ATOM   2844 C  CG2  A ILE   B 2 86  ? -13.91179 -20.87677 -23.25267 0.543 22.08348 ? 1138 ILE   B CG2  1 
ATOM   2845 C  CG2  B ILE   B 2 86  ? -14.18880 -20.80883 -23.14967 0.457 21.87611 ? 1138 ILE   B CG2  1 
ATOM   2846 C  CD1  A ILE   B 2 86  ? -15.32614 -18.40910 -22.43328 0.543 22.77817 ? 1138 ILE   B CD1  1 
ATOM   2847 C  CD1  B ILE   B 2 86  ? -15.79508 -19.43339 -21.17650 0.457 24.10281 ? 1138 ILE   B CD1  1 
ATOM   2848 N  N    . THR   B 2 87  ? -12.39657 -23.36787 -21.75706 1.000 22.57493 ? 1139 THR   B N    1 
ATOM   2849 C  CA   . THR   B 2 87  ? -11.41642 -24.31365 -22.27418 1.000 21.21238 ? 1139 THR   B CA   1 
ATOM   2850 C  C    . THR   B 2 87  ? -11.45033 -24.43537 -23.78721 1.000 24.41942 ? 1139 THR   B C    1 
ATOM   2851 O  O    . THR   B 2 87  ? -10.41226 -24.70813 -24.40120 1.000 28.58693 ? 1139 THR   B O    1 
ATOM   2852 C  CB   . THR   B 2 87  ? -11.65429 -25.70479 -21.68946 1.000 24.37819 ? 1139 THR   B CB   1 
ATOM   2853 O  OG1  . THR   B 2 87  ? -13.02023 -26.07091 -21.92760 1.000 21.97847 ? 1139 THR   B OG1  1 
ATOM   2854 C  CG2  . THR   B 2 87  ? -11.34836 -25.73804 -20.18645 1.000 27.07698 ? 1139 THR   B CG2  1 
ATOM   2855 N  N    . HIS   B 2 88  ? -12.61232 -24.24240 -24.39923 1.000 20.81389 ? 1140 HIS   B N    1 
ATOM   2856 C  CA   . HIS   B 2 88  ? -12.78220 -24.56815 -25.80630 1.000 22.97686 ? 1140 HIS   B CA   1 
ATOM   2857 C  C    . HIS   B 2 88  ? -14.05526 -23.89822 -26.28625 1.000 23.27373 ? 1140 HIS   B C    1 
ATOM   2858 O  O    . HIS   B 2 88  ? -14.98632 -23.68848 -25.50126 1.000 23.50546 ? 1140 HIS   B O    1 
ATOM   2859 C  CB   . HIS   B 2 88  ? -12.84501 -26.09212 -25.99460 1.000 28.17225 ? 1140 HIS   B CB   1 
ATOM   2860 C  CG   . HIS   B 2 88  ? -13.06087 -26.53088 -27.40969 1.000 30.22403 ? 1140 HIS   B CG   1 
ATOM   2861 N  ND1  . HIS   B 2 88  ? -14.31282 -26.78394 -27.92681 1.000 29.59084 ? 1140 HIS   B ND1  1 
ATOM   2862 C  CD2  . HIS   B 2 88  ? -12.18079 -26.79459 -28.40669 1.000 31.82253 ? 1140 HIS   B CD2  1 
ATOM   2863 C  CE1  . HIS   B 2 88  ? -14.19870 -27.16769 -29.18687 1.000 26.25254 ? 1140 HIS   B CE1  1 
ATOM   2864 N  NE2  . HIS   B 2 88  ? -12.91668 -27.18047 -29.50381 1.000 30.81972 ? 1140 HIS   B NE2  1 
ATOM   2865 N  N    . LEU   B 2 89  ? -14.08023 -23.54098 -27.57118 1.000 19.78957 ? 1141 LEU   B N    1 
ATOM   2866 C  CA   . LEU   B 2 89  ? -15.27727 -22.93801 -28.14613 1.000 21.58526 ? 1141 LEU   B CA   1 
ATOM   2867 C  C    . LEU   B 2 89  ? -15.38215 -23.30175 -29.62221 1.000 26.27687 ? 1141 LEU   B C    1 
ATOM   2868 O  O    . LEU   B 2 89  ? -14.41406 -23.73251 -30.24823 1.000 24.80316 ? 1141 LEU   B O    1 
ATOM   2869 C  CB   . LEU   B 2 89  ? -15.29247 -21.41305 -27.94284 1.000 26.04259 ? 1141 LEU   B CB   1 
ATOM   2870 C  CG   . LEU   B 2 89  ? -14.10654 -20.59782 -28.43463 1.000 32.27149 ? 1141 LEU   B CG   1 
ATOM   2871 C  CD1  . LEU   B 2 89  ? -14.17448 -20.45054 -29.93460 1.000 31.18710 ? 1141 LEU   B CD1  1 
ATOM   2872 C  CD2  . LEU   B 2 89  ? -14.09275 -19.23294 -27.76137 1.000 32.77476 ? 1141 LEU   B CD2  1 
ATOM   2873 N  N    . GLU   B 2 90  ? -16.58814 -23.13779 -30.17024 1.000 23.49608 ? 1142 GLU   B N    1 
ATOM   2874 C  CA   . GLU   B 2 90  ? -16.82803 -23.42855 -31.57931 1.000 25.27136 ? 1142 GLU   B CA   1 
ATOM   2875 C  C    . GLU   B 2 90  ? -17.96410 -22.57059 -32.10621 1.000 27.03716 ? 1142 GLU   B C    1 
ATOM   2876 O  O    . GLU   B 2 90  ? -19.09711 -22.68182 -31.62529 1.000 26.40006 ? 1142 GLU   B O    1 
ATOM   2877 C  CB   . GLU   B 2 90  ? -17.17783 -24.90055 -31.81161 1.000 24.25441 ? 1142 GLU   B CB   1 
ATOM   2878 C  CG   . GLU   B 2 90  ? -17.27871 -25.23329 -33.29667 1.000 22.60484 ? 1142 GLU   B CG   1 
ATOM   2879 C  CD   . GLU   B 2 90  ? -17.92853 -26.58431 -33.57596 1.000 28.86579 ? 1142 GLU   B CD   1 
ATOM   2880 O  OE1  . GLU   B 2 90  ? -18.22449 -27.32853 -32.63012 1.000 23.88085 ? 1142 GLU   B OE1  1 
ATOM   2881 O  OE2  . GLU   B 2 90  ? -18.16143 -26.89812 -34.76104 1.000 28.95915 ? 1142 GLU   B OE2  1 
ATOM   2882 N  N    . PRO   B 2 91  ? -17.71115 -21.71738 -33.09003 1.000 27.53864 ? 1143 PRO   B N    1 
ATOM   2883 C  CA   . PRO   B 2 91  ? -18.80221 -20.96739 -33.71095 1.000 27.22617 ? 1143 PRO   B CA   1 
ATOM   2884 C  C    . PRO   B 2 91  ? -19.46105 -21.79127 -34.79914 1.000 30.10681 ? 1143 PRO   B C    1 
ATOM   2885 O  O    . PRO   B 2 91  ? -18.83091 -22.64407 -35.42327 1.000 31.23836 ? 1143 PRO   B O    1 
ATOM   2886 C  CB   . PRO   B 2 91  ? -18.09333 -19.74120 -34.29268 1.000 29.12175 ? 1143 PRO   B CB   1 
ATOM   2887 C  CG   . PRO   B 2 91  ? -16.72825 -20.22597 -34.59970 1.000 34.29641 ? 1143 PRO   B CG   1 
ATOM   2888 C  CD   . PRO   B 2 91  ? -16.39217 -21.30812 -33.60188 1.000 27.07991 ? 1143 PRO   B CD   1 
ATOM   2889 N  N    . SER   B 2 92  ? -20.75907 -21.55839 -34.99217 1.000 27.24589 ? 1144 SER   B N    1 
ATOM   2890 C  CA   . SER   B 2 92  ? -21.42793 -22.19726 -36.10833 1.000 24.78481 ? 1144 SER   B CA   1 
ATOM   2891 C  C    . SER   B 2 92  ? -20.96894 -21.54396 -37.41118 1.000 27.90800 ? 1144 SER   B C    1 
ATOM   2892 O  O    . SER   B 2 92  ? -20.47908 -20.40989 -37.42694 1.000 31.75022 ? 1144 SER   B O    1 
ATOM   2893 C  CB   . SER   B 2 92  ? -22.94795 -22.11147 -35.95639 1.000 24.58225 ? 1144 SER   B CB   1 
ATOM   2894 O  OG   . SER   B 2 92  ? -23.43410 -20.78451 -36.08017 1.000 27.75801 ? 1144 SER   B OG   1 
ATOM   2895 N  N    . ARG   B 2 93  ? -21.11879 -22.27177 -38.51632 1.000 29.57467 ? 1145 ARG   B N    1 
ATOM   2896 C  CA   . ARG   B 2 93  ? -20.63679 -21.72447 -39.78519 1.000 37.05743 ? 1145 ARG   B CA   1 
ATOM   2897 C  C    . ARG   B 2 93  ? -21.42492 -20.48948 -40.20800 1.000 35.18518 ? 1145 ARG   B C    1 
ATOM   2898 O  O    . ARG   B 2 93  ? -20.85699 -19.58030 -40.82080 1.000 36.17481 ? 1145 ARG   B O    1 
ATOM   2899 C  CB   . ARG   B 2 93  ? -20.67360 -22.78827 -40.87840 1.000 32.05487 ? 1145 ARG   B CB   1 
ATOM   2900 C  CG   . ARG   B 2 93  ? -19.54748 -23.80016 -40.73953 1.000 38.17113 ? 1145 ARG   B CG   1 
ATOM   2901 C  CD   . ARG   B 2 93  ? -19.39131 -24.63890 -41.98668 1.000 40.07533 ? 1145 ARG   B CD   1 
ATOM   2902 N  NE   . ARG   B 2 93  ? -20.64021 -25.28798 -42.35787 1.000 37.13768 ? 1145 ARG   B NE   1 
ATOM   2903 C  CZ   . ARG   B 2 93  ? -21.04310 -26.45612 -41.87811 1.000 37.14265 ? 1145 ARG   B CZ   1 
ATOM   2904 N  NH1  . ARG   B 2 93  ? -20.32907 -27.11421 -40.98020 1.000 34.16844 ? 1145 ARG   B NH1  1 
ATOM   2905 N  NH2  . ARG   B 2 93  ? -22.19201 -26.96818 -42.30727 1.000 34.47912 ? 1145 ARG   B NH2  1 
ATOM   2906 N  N    . ASP   B 2 94  ? -22.71294 -20.41470 -39.87906 1.000 34.54022 ? 1146 ASP   B N    1 
ATOM   2907 C  CA   . ASP   B 2 94  ? -23.50206 -19.26872 -40.31489 1.000 40.91026 ? 1146 ASP   B CA   1 
ATOM   2908 C  C    . ASP   B 2 94  ? -23.35626 -18.05587 -39.40265 1.000 36.76894 ? 1146 ASP   B C    1 
ATOM   2909 O  O    . ASP   B 2 94  ? -24.03937 -17.05191 -39.62650 1.000 37.31232 ? 1146 ASP   B O    1 
ATOM   2910 C  CB   . ASP   B 2 94  ? -24.97800 -19.66387 -40.44204 1.000 33.91115 ? 1146 ASP   B CB   1 
ATOM   2911 C  CG   . ASP   B 2 94  ? -25.63104 -19.95720 -39.11013 1.000 42.24700 ? 1146 ASP   B CG   1 
ATOM   2912 O  OD1  . ASP   B 2 94  ? -24.99712 -19.73633 -38.05106 1.000 37.49985 ? 1146 ASP   B OD1  1 
ATOM   2913 O  OD2  . ASP   B 2 94  ? -26.79098 -20.41934 -39.12828 1.000 42.70494 ? 1146 ASP   B OD2  1 
ATOM   2914 N  N    . GLY   B 2 95  ? -22.49830 -18.12296 -38.38361 1.000 39.84978 ? 1147 GLY   B N    1 
ATOM   2915 C  CA   . GLY   B 2 95  ? -22.26549 -16.99910 -37.49739 1.000 39.97700 ? 1147 GLY   B CA   1 
ATOM   2916 C  C    . GLY   B 2 95  ? -23.34058 -16.72543 -36.46140 1.000 38.26060 ? 1147 GLY   B C    1 
ATOM   2917 O  O    . GLY   B 2 95  ? -23.18874 -15.78656 -35.67121 1.000 36.82485 ? 1147 GLY   B O    1 
ATOM   2918 N  N    . SER   B 2 96  ? -24.41448 -17.50956 -36.41960 1.000 37.83689 ? 1148 SER   B N    1 
ATOM   2919 C  CA   . SER   B 2 96  ? -25.50257 -17.20387 -35.50160 1.000 41.36075 ? 1148 SER   B CA   1 
ATOM   2920 C  C    . SER   B 2 96  ? -25.33257 -17.81511 -34.10971 1.000 31.60884 ? 1148 SER   B C    1 
ATOM   2921 O  O    . SER   B 2 96  ? -25.99268 -17.36137 -33.16866 1.000 31.70879 ? 1148 SER   B O    1 
ATOM   2922 C  CB   . SER   B 2 96  ? -26.82848 -17.66592 -36.10376 1.000 36.87039 ? 1148 SER   B CB   1 
ATOM   2923 O  OG   . SER   B 2 96  ? -26.75730 -19.02684 -36.47602 1.000 40.02427 ? 1148 SER   B OG   1 
ATOM   2924 N  N    . LEU   B 2 97  ? -24.47446 -18.81804 -33.94185 1.000 28.35742 ? 1149 LEU   B N    1 
ATOM   2925 C  CA   . LEU   B 2 97  ? -24.43144 -19.56427 -32.68999 1.000 27.13475 ? 1149 LEU   B CA   1 
ATOM   2926 C  C    . LEU   B 2 97  ? -22.98943 -19.82017 -32.28396 1.000 30.66859 ? 1149 LEU   B C    1 
ATOM   2927 O  O    . LEU   B 2 97  ? -22.09337 -19.88090 -33.13092 1.000 26.96865 ? 1149 LEU   B O    1 
ATOM   2928 C  CB   . LEU   B 2 97  ? -25.18127 -20.90134 -32.80929 1.000 25.52025 ? 1149 LEU   B CB   1 
ATOM   2929 C  CG   . LEU   B 2 97  ? -26.67726 -20.80946 -33.12135 1.000 28.18595 ? 1149 LEU   B CG   1 
ATOM   2930 C  CD1  . LEU   B 2 97  ? -27.23707 -22.16746 -33.52764 1.000 26.64801 ? 1149 LEU   B CD1  1 
ATOM   2931 C  CD2  . LEU   B 2 97  ? -27.42639 -20.26178 -31.91629 1.000 27.73120 ? 1149 LEU   B CD2  1 
ATOM   2932 N  N    . LEU   B 2 98  ? -22.77948 -19.99639 -30.97498 1.000 24.84118 ? 1150 LEU   B N    1 
ATOM   2933 C  CA   . LEU   B 2 98  ? -21.45147 -20.27534 -30.43196 1.000 24.35610 ? 1150 LEU   B CA   1 
ATOM   2934 C  C    . LEU   B 2 98  ? -21.54641 -21.27156 -29.28116 1.000 25.98374 ? 1150 LEU   B C    1 
ATOM   2935 O  O    . LEU   B 2 98  ? -22.36448 -21.10284 -28.37217 1.000 22.81192 ? 1150 LEU   B O    1 
ATOM   2936 C  CB   . LEU   B 2 98  ? -20.77466 -18.98334 -29.95768 1.000 27.01070 ? 1150 LEU   B CB   1 
ATOM   2937 C  CG   . LEU   B 2 98  ? -19.47967 -19.18333 -29.16865 1.000 24.82195 ? 1150 LEU   B CG   1 
ATOM   2938 C  CD1  . LEU   B 2 98  ? -18.30259 -19.48702 -30.08464 1.000 23.08303 ? 1150 LEU   B CD1  1 
ATOM   2939 C  CD2  . LEU   B 2 98  ? -19.18787 -17.96847 -28.28141 1.000 25.62028 ? 1150 LEU   B CD2  1 
ATOM   2940 N  N    . LEU   B 2 99  ? -20.71129 -22.30846 -29.31831 1.000 25.33194 ? 1151 LEU   B N    1 
ATOM   2941 C  CA   . LEU   B 2 99  ? -20.58423 -23.24065 -28.20748 1.000 21.97069 ? 1151 LEU   B CA   1 
ATOM   2942 C  C    . LEU   B 2 99  ? -19.38032 -22.85966 -27.36034 1.000 23.92530 ? 1151 LEU   B C    1 
ATOM   2943 O  O    . LEU   B 2 99  ? -18.32234 -22.50843 -27.89322 1.000 22.53759 ? 1151 LEU   B O    1 
ATOM   2944 C  CB   . LEU   B 2 99  ? -20.42603 -24.67754 -28.70274 1.000 21.72724 ? 1151 LEU   B CB   1 
ATOM   2945 C  CG   . LEU   B 2 99  ? -21.66992 -25.33257 -29.31093 1.000 23.36748 ? 1151 LEU   B CG   1 
ATOM   2946 C  CD1  . LEU   B 2 99  ? -21.29172 -26.64139 -30.02516 1.000 21.76439 ? 1151 LEU   B CD1  1 
ATOM   2947 C  CD2  . LEU   B 2 99  ? -22.71495 -25.58490 -28.23304 1.000 19.25467 ? 1151 LEU   B CD2  1 
ATOM   2948 N  N    . THR   B 2 100 ? -19.54539 -22.92393 -26.04036 1.000 20.09846 ? 1152 THR   B N    1 
ATOM   2949 C  CA   . THR   B 2 100 ? -18.44346 -22.71697 -25.11226 1.000 22.09581 ? 1152 THR   B CA   1 
ATOM   2950 C  C    . THR   B 2 100 ? -18.41838 -23.86316 -24.11348 1.000 23.18003 ? 1152 THR   B C    1 
ATOM   2951 O  O    . THR   B 2 100 ? -19.45032 -24.46034 -23.80465 1.000 19.64994 ? 1152 THR   B O    1 
ATOM   2952 C  CB   . THR   B 2 100 ? -18.55767 -21.37413 -24.34401 1.000 22.34951 ? 1152 THR   B CB   1 
ATOM   2953 O  OG1  . THR   B 2 100 ? -19.83371 -21.30041 -23.69207 1.000 22.62223 ? 1152 THR   B OG1  1 
ATOM   2954 C  CG2  . THR   B 2 100 ? -18.37977 -20.17093 -25.28778 1.000 23.43716 ? 1152 THR   B CG2  1 
ATOM   2955 N  N    . SER   B 2 101 ? -17.22737 -24.14311 -23.59847 1.000 21.81578 ? 1153 SER   B N    1 
ATOM   2956 C  CA   . SER   B 2 101 ? -17.02732 -25.08529 -22.51063 1.000 21.53401 ? 1153 SER   B CA   1 
ATOM   2957 C  C    . SER   B 2 101 ? -16.10645 -24.45438 -21.47146 1.000 24.59168 ? 1153 SER   B C    1 
ATOM   2958 O  O    . SER   B 2 101 ? -15.14652 -23.75019 -21.81828 1.000 23.79701 ? 1153 SER   B O    1 
ATOM   2959 C  CB   . SER   B 2 101 ? -16.43513 -26.40512 -23.01985 1.000 20.29517 ? 1153 SER   B CB   1 
ATOM   2960 O  OG   . SER   B 2 101 ? -17.33300 -27.01906 -23.93701 1.000 21.00416 ? 1153 SER   B OG   1 
ATOM   2961 N  N    . ALA   B 2 102 ? -16.40349 -24.70365 -20.20053 1.000 18.79572 ? 1154 ALA   B N    1 
ATOM   2962 C  CA   . ALA   B 2 102 ? -15.65562 -24.14777 -19.08638 1.000 22.50517 ? 1154 ALA   B CA   1 
ATOM   2963 C  C    . ALA   B 2 102 ? -14.86452 -25.26081 -18.40255 1.000 25.85187 ? 1154 ALA   B C    1 
ATOM   2964 O  O    . ALA   B 2 102 ? -14.80836 -26.39071 -18.88376 1.000 34.37905 ? 1154 ALA   B O    1 
ATOM   2965 C  CB   . ALA   B 2 102 ? -16.60976 -23.43407 -18.12630 1.000 21.90112 ? 1154 ALA   B CB   1 
ATOM   2966 N  N    A THR   B 2 103 ? -14.27162 -24.93895 -17.25445 0.620 21.43594 ? 1155 THR   B N    1 
ATOM   2967 N  N    B THR   B 2 103 ? -14.23962 -24.94094 -17.27145 0.380 21.51342 ? 1155 THR   B N    1 
ATOM   2968 C  CA   A THR   B 2 103 ? -13.35955 -25.85697 -16.58158 0.620 26.52833 ? 1155 THR   B CA   1 
ATOM   2969 C  CA   B THR   B 2 103 ? -13.38854 -25.92496 -16.60859 0.380 26.47905 ? 1155 THR   B CA   1 
ATOM   2970 C  C    A THR   B 2 103 ? -14.06950 -26.71925 -15.53678 0.620 24.07779 ? 1155 THR   B C    1 
ATOM   2971 C  C    B THR   B 2 103 ? -14.15449 -26.74425 -15.57279 0.380 24.06188 ? 1155 THR   B C    1 
ATOM   2972 O  O    A THR   B 2 103 ? -14.03934 -27.94923 -15.61701 0.620 24.89591 ? 1155 THR   B O    1 
ATOM   2973 O  O    B THR   B 2 103 ? -14.24934 -27.96924 -15.69303 0.380 24.87970 ? 1155 THR   B O    1 
ATOM   2974 C  CB   A THR   B 2 103 ? -12.21568 -25.06495 -15.94537 0.620 25.36111 ? 1155 THR   B CB   1 
ATOM   2975 C  CB   B THR   B 2 103 ? -12.18065 -25.23794 -15.96640 0.380 25.34110 ? 1155 THR   B CB   1 
ATOM   2976 O  OG1  A THR   B 2 103 ? -11.56472 -24.28268 -16.95818 0.620 27.25175 ? 1155 THR   B OG1  1 
ATOM   2977 O  OG1  B THR   B 2 103 ? -12.63083 -24.19716 -15.09223 0.380 24.56085 ? 1155 THR   B OG1  1 
ATOM   2978 C  CG2  A THR   B 2 103 ? -11.20860 -25.99794 -15.32549 0.620 22.52424 ? 1155 THR   B CG2  1 
ATOM   2979 C  CG2  B THR   B 2 103 ? -11.28667 -24.64363 -17.04424 0.380 26.69886 ? 1155 THR   B CG2  1 
ATOM   2980 N  N    . TRP   B 2 104 ? -14.71163 -26.08951 -14.55370 1.000 21.96674 ? 1156 TRP   B N    1 
ATOM   2981 C  CA   . TRP   B 2 104 ? -15.33660 -26.82380 -13.45187 1.000 23.29776 ? 1156 TRP   B CA   1 
ATOM   2982 C  C    . TRP   B 2 104 ? -16.72868 -26.32604 -13.06585 1.000 24.01006 ? 1156 TRP   B C    1 
ATOM   2983 O  O    . TRP   B 2 104 ? -17.49062 -27.10124 -12.47704 1.000 27.01887 ? 1156 TRP   B O    1 
ATOM   2984 C  CB   . TRP   B 2 104 ? -14.42867 -26.79092 -12.20581 1.000 24.24623 ? 1156 TRP   B CB   1 
ATOM   2985 C  CG   . TRP   B 2 104 ? -14.25087 -25.41201 -11.63054 1.000 25.88435 ? 1156 TRP   B CG   1 
ATOM   2986 C  CD1  . TRP   B 2 104 ? -13.19796 -24.55984 -11.83832 1.000 23.73516 ? 1156 TRP   B CD1  1 
ATOM   2987 C  CD2  . TRP   B 2 104 ? -15.16800 -24.71228 -10.77146 1.000 23.11600 ? 1156 TRP   B CD2  1 
ATOM   2988 N  NE1  . TRP   B 2 104 ? -13.40114 -23.38200 -11.15611 1.000 24.46159 ? 1156 TRP   B NE1  1 
ATOM   2989 C  CE2  . TRP   B 2 104 ? -14.60217 -23.45227 -10.49319 1.000 27.62124 ? 1156 TRP   B CE2  1 
ATOM   2990 C  CE3  . TRP   B 2 104 ? -16.40099 -25.03854 -10.19859 1.000 21.80664 ? 1156 TRP   B CE3  1 
ATOM   2991 C  CZ2  . TRP   B 2 104 ? -15.23433 -22.50850 -9.67205  1.000 27.41967 ? 1156 TRP   B CZ2  1 
ATOM   2992 C  CZ3  . TRP   B 2 104 ? -17.03315 -24.09277 -9.38344  1.000 25.69614 ? 1156 TRP   B CZ3  1 
ATOM   2993 C  CH2  . TRP   B 2 104 ? -16.44732 -22.84975 -9.12918  1.000 25.39497 ? 1156 TRP   B CH2  1 
ATOM   2994 N  N    . SER   B 2 105 ? -17.09581 -25.08903 -13.37564 1.000 24.14513 ? 1157 SER   B N    1 
ATOM   2995 C  CA   . SER   B 2 105 ? -18.37390 -24.55226 -12.93960 1.000 25.64325 ? 1157 SER   B CA   1 
ATOM   2996 C  C    . SER   B 2 105 ? -19.48880 -25.01523 -13.86275 1.000 28.70133 ? 1157 SER   B C    1 
ATOM   2997 O  O    . SER   B 2 105 ? -19.30171 -25.14497 -15.07677 1.000 26.33542 ? 1157 SER   B O    1 
ATOM   2998 C  CB   . SER   B 2 105 ? -18.32909 -23.02527 -12.90431 1.000 24.61433 ? 1157 SER   B CB   1 
ATOM   2999 O  OG   . SER   B 2 105 ? -17.89009 -22.51198 -14.15119 1.000 25.85587 ? 1157 SER   B OG   1 
ATOM   3000 N  N    . GLN   B 2 106 ? -20.64880 -25.26748 -13.28186 1.000 21.43399 ? 1158 GLN   B N    1 
ATOM   3001 C  CA   . GLN   B 2 106 ? -21.80071 -25.61747 -14.08699 1.000 25.14724 ? 1158 GLN   B CA   1 
ATOM   3002 C  C    . GLN   B 2 106 ? -22.58484 -24.36050 -14.42880 1.000 23.21413 ? 1158 GLN   B C    1 
ATOM   3003 O  O    . GLN   B 2 106 ? -22.66400 -23.44466 -13.61063 1.000 25.55574 ? 1158 GLN   B O    1 
ATOM   3004 C  CB   . GLN   B 2 106 ? -22.70363 -26.60772 -13.34023 1.000 26.76276 ? 1158 GLN   B CB   1 
ATOM   3005 C  CG   . GLN   B 2 106 ? -21.97549 -27.92569 -13.01444 1.000 26.91925 ? 1158 GLN   B CG   1 
ATOM   3006 C  CD   . GLN   B 2 106 ? -22.86639 -28.98092 -12.38669 1.000 29.75081 ? 1158 GLN   B CD   1 
ATOM   3007 O  OE1  . GLN   B 2 106 ? -23.84947 -28.66316 -11.74368 1.000 32.74460 ? 1158 GLN   B OE1  1 
ATOM   3008 N  NE2  . GLN   B 2 106 ? -22.53123 -30.24684 -12.59691 1.000 27.75260 ? 1158 GLN   B NE2  1 
ATOM   3009 N  N    . PRO   B 2 107 ? -23.17379 -24.30534 -15.63182 1.000 25.94069 ? 1159 PRO   B N    1 
ATOM   3010 C  CA   . PRO   B 2 107 ? -23.15560 -25.34914 -16.66802 1.000 21.93168 ? 1159 PRO   B CA   1 
ATOM   3011 C  C    . PRO   B 2 107 ? -21.77056 -25.45285 -17.30796 1.000 24.21888 ? 1159 PRO   B C    1 
ATOM   3012 O  O    . PRO   B 2 107 ? -21.16566 -24.42672 -17.61073 1.000 19.66397 ? 1159 PRO   B O    1 
ATOM   3013 C  CB   . PRO   B 2 107 ? -24.22261 -24.86909 -17.66398 1.000 25.01594 ? 1159 PRO   B CB   1 
ATOM   3014 C  CG   . PRO   B 2 107 ? -24.22480 -23.36211 -17.51670 1.000 23.29424 ? 1159 PRO   B CG   1 
ATOM   3015 C  CD   . PRO   B 2 107 ? -23.94591 -23.11936 -16.04764 1.000 23.74041 ? 1159 PRO   B CD   1 
ATOM   3016 N  N    . LEU   B 2 108 ? -21.26939 -26.67175 -17.53816 1.000 22.45816 ? 1160 LEU   B N    1 
ATOM   3017 C  CA   . LEU   B 2 108 ? -19.93434 -26.83348 -18.10112 1.000 21.99266 ? 1160 LEU   B CA   1 
ATOM   3018 C  C    . LEU   B 2 108 ? -19.86331 -26.42019 -19.56404 1.000 21.27246 ? 1160 LEU   B C    1 
ATOM   3019 O  O    . LEU   B 2 108 ? -18.79534 -26.02098 -20.03391 1.000 25.50014 ? 1160 LEU   B O    1 
ATOM   3020 C  CB   . LEU   B 2 108 ? -19.47018 -28.27346 -17.92537 1.000 24.61735 ? 1160 LEU   B CB   1 
ATOM   3021 C  CG   . LEU   B 2 108 ? -19.00022 -28.55267 -16.48939 1.000 26.76511 ? 1160 LEU   B CG   1 
ATOM   3022 C  CD1  . LEU   B 2 108 ? -18.77205 -30.03168 -16.29766 1.000 25.27906 ? 1160 LEU   B CD1  1 
ATOM   3023 C  CD2  . LEU   B 2 108 ? -17.72734 -27.75758 -16.15418 1.000 28.18846 ? 1160 LEU   B CD2  1 
ATOM   3024 N  N    . SER   B 2 109 ? -20.97127 -26.48719 -20.29311 1.000 21.78341 ? 1161 SER   B N    1 
ATOM   3025 C  CA   . SER   B 2 109 ? -21.00425 -26.01494 -21.67402 1.000 19.24289 ? 1161 SER   B CA   1 
ATOM   3026 C  C    . SER   B 2 109 ? -22.27433 -25.21305 -21.89794 1.000 21.05381 ? 1161 SER   B C    1 
ATOM   3027 O  O    . SER   B 2 109 ? -23.27435 -25.38330 -21.19403 1.000 22.52903 ? 1161 SER   B O    1 
ATOM   3028 C  CB   . SER   B 2 109 ? -20.92705 -27.17374 -22.67024 1.000 18.37094 ? 1161 SER   B CB   1 
ATOM   3029 O  OG   . SER   B 2 109 ? -19.64198 -27.77759 -22.61428 1.000 24.32949 ? 1161 SER   B OG   1 
ATOM   3030 N  N    . ALA   B 2 110 ? -22.23439 -24.32985 -22.89377 1.000 21.96210 ? 1162 ALA   B N    1 
ATOM   3031 C  CA   . ALA   B 2 110 ? -23.40847 -23.52994 -23.21269 1.000 19.64842 ? 1162 ALA   B CA   1 
ATOM   3032 C  C    . ALA   B 2 110 ? -23.44243 -23.20266 -24.70263 1.000 24.72116 ? 1162 ALA   B C    1 
ATOM   3033 O  O    . ALA   B 2 110 ? -22.42638 -23.27240 -25.40458 1.000 23.58472 ? 1162 ALA   B O    1 
ATOM   3034 C  CB   . ALA   B 2 110 ? -23.43967 -22.24110 -22.37144 1.000 19.01531 ? 1162 ALA   B CB   1 
ATOM   3035 N  N    . LEU   B 2 111 ? -24.64144 -22.85572 -25.16962 1.000 24.19834 ? 1163 LEU   B N    1 
ATOM   3036 C  CA   . LEU   B 2 111 ? -24.90142 -22.43349 -26.54356 1.000 23.59903 ? 1163 LEU   B CA   1 
ATOM   3037 C  C    . LEU   B 2 111 ? -25.38360 -20.98955 -26.51731 1.000 23.81436 ? 1163 LEU   B C    1 
ATOM   3038 O  O    . LEU   B 2 111 ? -26.35168 -20.66580 -25.81730 1.000 25.67262 ? 1163 LEU   B O    1 
ATOM   3039 C  CB   . LEU   B 2 111 ? -25.93927 -23.34749 -27.21079 1.000 18.85733 ? 1163 LEU   B CB   1 
ATOM   3040 C  CG   . LEU   B 2 111 ? -26.39024 -22.97028 -28.61574 1.000 24.70401 ? 1163 LEU   B CG   1 
ATOM   3041 C  CD1  . LEU   B 2 111 ? -25.22217 -23.14195 -29.60071 1.000 24.54159 ? 1163 LEU   B CD1  1 
ATOM   3042 C  CD2  . LEU   B 2 111 ? -27.60312 -23.79535 -29.04596 1.000 23.82363 ? 1163 LEU   B CD2  1 
ATOM   3043 N  N    . TRP   B 2 112 ? -24.70866 -20.12233 -27.26711 1.000 24.31164 ? 1164 TRP   B N    1 
ATOM   3044 C  CA   . TRP   B 2 112 ? -24.98084 -18.69537 -27.25086 1.000 25.88987 ? 1164 TRP   B CA   1 
ATOM   3045 C  C    . TRP   B 2 112 ? -25.49982 -18.24217 -28.60580 1.000 30.28110 ? 1164 TRP   B C    1 
ATOM   3046 O  O    . TRP   B 2 112 ? -25.00971 -18.68692 -29.64786 1.000 28.09403 ? 1164 TRP   B O    1 
ATOM   3047 C  CB   . TRP   B 2 112 ? -23.72396 -17.89728 -26.88664 1.000 23.11474 ? 1164 TRP   B CB   1 
ATOM   3048 C  CG   . TRP   B 2 112 ? -23.08596 -18.41244 -25.64870 1.000 25.45700 ? 1164 TRP   B CG   1 
ATOM   3049 C  CD1  . TRP   B 2 112 ? -22.15984 -19.40934 -25.56184 1.000 25.64876 ? 1164 TRP   B CD1  1 
ATOM   3050 C  CD2  . TRP   B 2 112 ? -23.34908 -17.98572 -24.30663 1.000 24.33566 ? 1164 TRP   B CD2  1 
ATOM   3051 N  NE1  . TRP   B 2 112 ? -21.81189 -19.61655 -24.24186 1.000 21.43140 ? 1164 TRP   B NE1  1 
ATOM   3052 C  CE2  . TRP   B 2 112 ? -22.53404 -18.75879 -23.45274 1.000 23.37450 ? 1164 TRP   B CE2  1 
ATOM   3053 C  CE3  . TRP   B 2 112 ? -24.19623 -17.01793 -23.74150 1.000 25.63736 ? 1164 TRP   B CE3  1 
ATOM   3054 C  CZ2  . TRP   B 2 112 ? -22.54013 -18.60005 -22.05471 1.000 20.14707 ? 1164 TRP   B CZ2  1 
ATOM   3055 C  CZ3  . TRP   B 2 112 ? -24.19633 -16.85719 -22.35947 1.000 22.27408 ? 1164 TRP   B CZ3  1 
ATOM   3056 C  CH2  . TRP   B 2 112 ? -23.36628 -17.63825 -21.53457 1.000 21.03017 ? 1164 TRP   B CH2  1 
ATOM   3057 N  N    . GLY   B 2 113 ? -26.50193 -17.36530 -28.58369 1.000 33.32742 ? 1165 GLY   B N    1 
ATOM   3058 C  CA   . GLY   B 2 113 ? -26.97294 -16.71613 -29.79459 1.000 29.06287 ? 1165 GLY   B CA   1 
ATOM   3059 C  C    . GLY   B 2 113 ? -26.16408 -15.45799 -30.02631 1.000 34.56909 ? 1165 GLY   B C    1 
ATOM   3060 O  O    . GLY   B 2 113 ? -25.92723 -14.68013 -29.09815 1.000 38.86066 ? 1165 GLY   B O    1 
ATOM   3061 N  N    . MET   B 2 114 ? -25.72704 -15.26670 -31.26625 1.000 39.75718 ? 1166 MET   B N    1 
ATOM   3062 C  CA   . MET   B 2 114 ? -24.92816 -14.10154 -31.60699 1.000 45.93331 ? 1166 MET   B CA   1 
ATOM   3063 C  C    . MET   B 2 114 ? -25.62723 -13.13544 -32.55784 1.000 50.51304 ? 1166 MET   B C    1 
ATOM   3064 O  O    . MET   B 2 114 ? -25.16636 -12.00036 -32.70360 1.000 62.66065 ? 1166 MET   B O    1 
ATOM   3065 C  CB   . MET   B 2 114 ? -23.58407 -14.55726 -32.18500 1.000 43.46708 ? 1166 MET   B CB   1 
ATOM   3066 C  CG   . MET   B 2 114 ? -22.81603 -15.38436 -31.16711 1.000 41.34708 ? 1166 MET   B CG   1 
ATOM   3067 S  SD   . MET   B 2 114 ? -21.04403 -15.32111 -31.37001 1.000 46.27405 ? 1166 MET   B SD   1 
ATOM   3068 C  CE   . MET   B 2 114 ? -20.81981 -16.45282 -32.74121 1.000 40.14544 ? 1166 MET   B CE   1 
ATOM   3069 N  N    . LYS   B 2 115 ? -26.73415 -13.53446 -33.17798 1.000 50.34554 ? 1167 LYS   B N    1 
ATOM   3070 C  CA   . LYS   B 2 115 ? -27.54522 -12.58942 -33.93384 1.000 61.55675 ? 1167 LYS   B CA   1 
ATOM   3071 C  C    . LYS   B 2 115 ? -27.96541 -11.43464 -33.03465 1.000 64.49880 ? 1167 LYS   B C    1 
ATOM   3072 O  O    . LYS   B 2 115 ? -28.51544 -11.64691 -31.95172 1.000 67.54946 ? 1167 LYS   B O    1 
ATOM   3073 C  CB   . LYS   B 2 115 ? -28.78910 -13.27646 -34.50404 1.000 62.16002 ? 1167 LYS   B CB   1 
ATOM   3074 C  CG   . LYS   B 2 115 ? -28.55792 -14.24121 -35.65521 1.000 66.55353 ? 1167 LYS   B CG   1 
ATOM   3075 C  CD   . LYS   B 2 115 ? -29.89083 -14.84829 -36.09540 1.000 70.51405 ? 1167 LYS   B CD   1 
ATOM   3076 C  CE   . LYS   B 2 115 ? -29.73765 -15.76105 -37.30056 1.000 82.78406 ? 1167 LYS   B CE   1 
ATOM   3077 N  NZ   . LYS   B 2 115 ? -31.03355 -16.41514 -37.66576 1.000 85.97034 ? 1167 LYS   B NZ   1 
ATOM   3078 N  N    . SER   B 2 116 ? -27.71253 -10.20852 -33.49140 1.000 60.29598 ? 1168 SER   B N    1 
ATOM   3079 C  CA   . SER   B 2 116 ? -28.03372 -9.01871  -32.71019 1.000 69.02689 ? 1168 SER   B CA   1 
ATOM   3080 C  C    . SER   B 2 116 ? -27.47578 -9.12991  -31.29419 1.000 64.64659 ? 1168 SER   B C    1 
ATOM   3081 O  O    . SER   B 2 116 ? -26.26882 -8.96780  -31.08409 1.000 72.64569 ? 1168 SER   B O    1 
ATOM   3082 C  CB   . SER   B 2 116 ? -29.54875 -8.79090  -32.67023 1.000 67.00002 ? 1168 SER   B CB   1 
ATOM   3083 O  OG   . SER   B 2 116 ? -30.21565 -9.86910  -32.03747 1.000 74.90522 ? 1168 SER   B OG   1 
ATOM   3084 N  N    . VAL   B 2 117 ? -28.33880 -9.42120  -30.32229 1.000 56.80059 ? 1169 VAL   B N    1 
ATOM   3085 C  CA   . VAL   B 2 117 ? -27.91687 -9.49341  -28.92728 1.000 58.11672 ? 1169 VAL   B CA   1 
ATOM   3086 C  C    . VAL   B 2 117 ? -27.21572 -10.82137 -28.66549 1.000 57.54136 ? 1169 VAL   B C    1 
ATOM   3087 O  O    . VAL   B 2 117 ? -27.59456 -11.86932 -29.20671 1.000 56.52475 ? 1169 VAL   B O    1 
ATOM   3088 C  CB   . VAL   B 2 117 ? -29.11894 -9.29773  -27.98931 1.000 50.19161 ? 1169 VAL   B CB   1 
ATOM   3089 C  CG1  . VAL   B 2 117 ? -29.69910 -7.90577  -28.15608 1.000 57.43931 ? 1169 VAL   B CG1  1 
ATOM   3090 C  CG2  . VAL   B 2 117 ? -30.17780 -10.34181 -28.27556 1.000 62.26908 ? 1169 VAL   B CG2  1 
ATOM   3091 N  N    . PHE   B 2 118 ? -26.17077 -10.76840 -27.84342 1.000 43.58443 ? 1170 PHE   B N    1 
ATOM   3092 C  CA   . PHE   B 2 118 ? -25.45365 -11.95240 -27.39561 1.000 40.48594 ? 1170 PHE   B CA   1 
ATOM   3093 C  C    . PHE   B 2 118 ? -26.10866 -12.46172 -26.11974 1.000 39.39881 ? 1170 PHE   B C    1 
ATOM   3094 O  O    . PHE   B 2 118 ? -26.12680 -11.75791 -25.10661 1.000 40.82721 ? 1170 PHE   B O    1 
ATOM   3095 C  CB   . PHE   B 2 118 ? -23.98971 -11.61927 -27.14047 1.000 36.63456 ? 1170 PHE   B CB   1 
ATOM   3096 C  CG   . PHE   B 2 118 ? -23.14958 -12.80624 -26.74865 1.000 33.34479 ? 1170 PHE   B CG   1 
ATOM   3097 C  CD1  . PHE   B 2 118 ? -23.06661 -13.20548 -25.43072 1.000 31.73475 ? 1170 PHE   B CD1  1 
ATOM   3098 C  CD2  . PHE   B 2 118 ? -22.41645 -13.49897 -27.70174 1.000 36.65832 ? 1170 PHE   B CD2  1 
ATOM   3099 C  CE1  . PHE   B 2 118 ? -22.27649 -14.28845 -25.06988 1.000 34.87117 ? 1170 PHE   B CE1  1 
ATOM   3100 C  CE2  . PHE   B 2 118 ? -21.61934 -14.57594 -27.34890 1.000 39.96315 ? 1170 PHE   B CE2  1 
ATOM   3101 C  CZ   . PHE   B 2 118 ? -21.55036 -14.97118 -26.02897 1.000 27.39336 ? 1170 PHE   B CZ   1 
ATOM   3102 N  N    . ASP   B 2 119 ? -26.64051 -13.67777 -26.16700 1.000 35.92115 ? 1171 ASP   B N    1 
ATOM   3103 C  CA   . ASP   B 2 119 ? -27.36951 -14.21208 -25.02814 1.000 39.55910 ? 1171 ASP   B CA   1 
ATOM   3104 C  C    . ASP   B 2 119 ? -27.27832 -15.73106 -25.05442 1.000 35.90509 ? 1171 ASP   B C    1 
ATOM   3105 O  O    . ASP   B 2 119 ? -26.92419 -16.33683 -26.06852 1.000 29.30337 ? 1171 ASP   B O    1 
ATOM   3106 C  CB   . ASP   B 2 119 ? -28.83256 -13.76125 -25.04713 1.000 39.36531 ? 1171 ASP   B CB   1 
ATOM   3107 C  CG   . ASP   B 2 119 ? -29.59043 -14.31812 -26.23828 1.000 45.04289 ? 1171 ASP   B CG   1 
ATOM   3108 O  OD1  . ASP   B 2 119 ? -28.94533 -14.68485 -27.25331 1.000 48.60979 ? 1171 ASP   B OD1  1 
ATOM   3109 O  OD2  . ASP   B 2 119 ? -30.83442 -14.39329 -26.16136 1.000 66.95097 ? 1171 ASP   B OD2  1 
ATOM   3110 N  N    . MET   B 2 120 ? -27.60531 -16.34331 -23.92456 1.000 29.11403 ? 1172 MET   B N    1 
ATOM   3111 C  CA   . MET   B 2 120 ? -27.59713 -17.79333 -23.84283 1.000 31.76239 ? 1172 MET   B CA   1 
ATOM   3112 C  C    . MET   B 2 120 ? -28.86403 -18.37837 -24.45901 1.000 34.96883 ? 1172 MET   B C    1 
ATOM   3113 O  O    . MET   B 2 120 ? -29.97610 -17.96056 -24.12899 1.000 32.92815 ? 1172 MET   B O    1 
ATOM   3114 C  CB   . MET   B 2 120 ? -27.47116 -18.24159 -22.39091 1.000 25.22072 ? 1172 MET   B CB   1 
ATOM   3115 C  CG   . MET   B 2 120 ? -27.54698 -19.74862 -22.25620 1.000 32.96116 ? 1172 MET   B CG   1 
ATOM   3116 S  SD   . MET   B 2 120 ? -27.55001 -20.27395 -20.55129 1.000 35.20909 ? 1172 MET   B SD   1 
ATOM   3117 C  CE   . MET   B 2 120 ? -25.85607 -19.96183 -20.06014 1.000 35.03245 ? 1172 MET   B CE   1 
ATOM   3118 N  N    . LYS   B 2 121 ? -28.69686 -19.35818 -25.34918 1.000 25.51021 ? 1173 LYS   B N    1 
ATOM   3119 C  CA   . LYS   B 2 121 ? -29.83774 -20.11322 -25.85139 1.000 29.47704 ? 1173 LYS   B CA   1 
ATOM   3120 C  C    . LYS   B 2 121 ? -30.12064 -21.32642 -24.98063 1.000 29.87701 ? 1173 LYS   B C    1 
ATOM   3121 O  O    . LYS   B 2 121 ? -31.26664 -21.55364 -24.57574 1.000 27.84642 ? 1173 LYS   B O    1 
ATOM   3122 C  CB   . LYS   B 2 121 ? -29.60161 -20.56692 -27.29946 1.000 30.88450 ? 1173 LYS   B CB   1 
ATOM   3123 C  CG   . LYS   B 2 121 ? -29.47369 -19.44171 -28.31024 1.000 37.75560 ? 1173 LYS   B CG   1 
ATOM   3124 C  CD   . LYS   B 2 121 ? -30.77178 -18.66785 -28.40417 1.000 46.46940 ? 1173 LYS   B CD   1 
ATOM   3125 C  CE   . LYS   B 2 121 ? -30.79983 -17.74363 -29.61699 1.000 46.04140 ? 1173 LYS   B CE   1 
ATOM   3126 N  NZ   . LYS   B 2 121 ? -32.07092 -16.95778 -29.65091 1.000 55.02532 ? 1173 LYS   B NZ   1 
ATOM   3127 N  N    . HIS   B 2 122 ? -29.08556 -22.11935 -24.69973 1.000 27.80304 ? 1174 HIS   B N    1 
ATOM   3128 C  CA   . HIS   B 2 122 ? -29.22845 -23.36151 -23.94397 1.000 27.31374 ? 1174 HIS   B CA   1 
ATOM   3129 C  C    . HIS   B 2 122 ? -27.97146 -23.60251 -23.13095 1.000 27.80708 ? 1174 HIS   B C    1 
ATOM   3130 O  O    . HIS   B 2 122 ? -26.89651 -23.08632 -23.44279 1.000 23.96582 ? 1174 HIS   B O    1 
ATOM   3131 C  CB   . HIS   B 2 122 ? -29.46125 -24.57537 -24.84921 1.000 25.30651 ? 1174 HIS   B CB   1 
ATOM   3132 C  CG   . HIS   B 2 122 ? -30.74622 -24.51438 -25.60727 1.000 26.69243 ? 1174 HIS   B CG   1 
ATOM   3133 N  ND1  . HIS   B 2 122 ? -31.97126 -24.48665 -24.98033 1.000 25.48711 ? 1174 HIS   B ND1  1 
ATOM   3134 C  CD2  . HIS   B 2 122 ? -30.99916 -24.44316 -26.93627 1.000 30.77603 ? 1174 HIS   B CD2  1 
ATOM   3135 C  CE1  . HIS   B 2 122 ? -32.92622 -24.41159 -25.89037 1.000 30.20684 ? 1174 HIS   B CE1  1 
ATOM   3136 N  NE2  . HIS   B 2 122 ? -32.36316 -24.37630 -27.08633 1.000 30.62444 ? 1174 HIS   B NE2  1 
ATOM   3137 N  N    . SER   B 2 123 ? -28.10442 -24.42372 -22.10011 1.000 23.41256 ? 1175 SER   B N    1 
ATOM   3138 C  CA   . SER   B 2 123 ? -26.95042 -24.79873 -21.30112 1.000 24.33422 ? 1175 SER   B CA   1 
ATOM   3139 C  C    . SER   B 2 123 ? -26.91524 -26.31075 -21.16240 1.000 26.82867 ? 1175 SER   B C    1 
ATOM   3140 O  O    . SER   B 2 123 ? -27.95216 -26.97688 -21.16558 1.000 25.24346 ? 1175 SER   B O    1 
ATOM   3141 C  CB   . SER   B 2 123 ? -26.98557 -24.12599 -19.92499 1.000 25.01918 ? 1175 SER   B CB   1 
ATOM   3142 O  OG   . SER   B 2 123 ? -28.11556 -24.56727 -19.19314 1.000 26.64851 ? 1175 SER   B OG   1 
ATOM   3143 N  N    . PHE   B 2 124 ? -25.70918 -26.84863 -21.05144 1.000 23.70823 ? 1176 PHE   B N    1 
ATOM   3144 C  CA   . PHE   B 2 124 ? -25.49201 -28.28662 -20.95970 1.000 28.27611 ? 1176 PHE   B CA   1 
ATOM   3145 C  C    . PHE   B 2 124 ? -24.70706 -28.49576 -19.67469 1.000 28.24888 ? 1176 PHE   B C    1 
ATOM   3146 O  O    . PHE   B 2 124 ? -23.50009 -28.23863 -19.62158 1.000 26.67916 ? 1176 PHE   B O    1 
ATOM   3147 C  CB   . PHE   B 2 124 ? -24.76988 -28.80629 -22.20476 1.000 24.49045 ? 1176 PHE   B CB   1 
ATOM   3148 C  CG   . PHE   B 2 124 ? -25.35287 -28.28512 -23.48669 1.000 22.49492 ? 1176 PHE   B CG   1 
ATOM   3149 C  CD1  . PHE   B 2 124 ? -26.57179 -28.74919 -23.94484 1.000 22.88298 ? 1176 PHE   B CD1  1 
ATOM   3150 C  CD2  . PHE   B 2 124 ? -24.70496 -27.29391 -24.20447 1.000 23.19503 ? 1176 PHE   B CD2  1 
ATOM   3151 C  CE1  . PHE   B 2 124 ? -27.13179 -28.24703 -25.11878 1.000 26.88804 ? 1176 PHE   B CE1  1 
ATOM   3152 C  CE2  . PHE   B 2 124 ? -25.24295 -26.78575 -25.37440 1.000 24.83618 ? 1176 PHE   B CE2  1 
ATOM   3153 C  CZ   . PHE   B 2 124 ? -26.46287 -27.26681 -25.83756 1.000 22.59151 ? 1176 PHE   B CZ   1 
ATOM   3154 N  N    . THR   B 2 125 ? -25.40706 -28.95505 -18.63882 1.000 24.79902 ? 1177 THR   B N    1 
ATOM   3155 C  CA   . THR   B 2 125 ? -24.92715 -28.79525 -17.26876 1.000 26.14098 ? 1177 THR   B CA   1 
ATOM   3156 C  C    . THR   B 2 125 ? -23.62607 -29.53913 -17.03483 1.000 24.60868 ? 1177 THR   B C    1 
ATOM   3157 O  O    . THR   B 2 125 ? -22.66917 -28.98312 -16.47568 1.000 24.51242 ? 1177 THR   B O    1 
ATOM   3158 C  CB   . THR   B 2 125 ? -26.00714 -29.27956 -16.29791 1.000 29.01562 ? 1177 THR   B CB   1 
ATOM   3159 O  OG1  . THR   B 2 125 ? -27.17723 -28.46067 -16.45582 1.000 26.30889 ? 1177 THR   B OG1  1 
ATOM   3160 C  CG2  . THR   B 2 125 ? -25.49923 -29.25277 -14.84688 1.000 30.52658 ? 1177 THR   B CG2  1 
ATOM   3161 N  N    . GLU   B 2 126 ? -23.56690 -30.80105 -17.45207 1.000 21.26572 ? 1178 GLU   B N    1 
ATOM   3162 C  CA   . GLU   B 2 126 ? -22.46481 -31.68098 -17.10617 1.000 21.54284 ? 1178 GLU   B CA   1 
ATOM   3163 C  C    . GLU   B 2 126 ? -21.55170 -32.02164 -18.27519 1.000 22.33026 ? 1178 GLU   B C    1 
ATOM   3164 O  O    . GLU   B 2 126 ? -20.57062 -32.74456 -18.07127 1.000 25.08347 ? 1178 GLU   B O    1 
ATOM   3165 C  CB   . GLU   B 2 126 ? -23.00268 -32.97916 -16.49645 1.000 28.33837 ? 1178 GLU   B CB   1 
ATOM   3166 C  CG   . GLU   B 2 126 ? -23.76778 -32.75049 -15.20845 1.000 32.72390 ? 1178 GLU   B CG   1 
ATOM   3167 C  CD   . GLU   B 2 126 ? -24.25566 -34.04467 -14.57272 1.000 46.13711 ? 1178 GLU   B CD   1 
ATOM   3168 O  OE1  . GLU   B 2 126 ? -24.69351 -34.95359 -15.31491 1.000 48.52767 ? 1178 GLU   B OE1  1 
ATOM   3169 O  OE2  . GLU   B 2 126 ? -24.19771 -34.14290 -13.32773 1.000 53.01789 ? 1178 GLU   B OE2  1 
ATOM   3170 N  N    . ASP   B 2 127 ? -21.83470 -31.53145 -19.48211 1.000 21.62913 ? 1179 ASP   B N    1 
ATOM   3171 C  CA   . ASP   B 2 127 ? -20.98660 -31.83513 -20.63812 1.000 21.84005 ? 1179 ASP   B CA   1 
ATOM   3172 C  C    . ASP   B 2 127 ? -19.78071 -30.89999 -20.61588 1.000 22.45638 ? 1179 ASP   B C    1 
ATOM   3173 O  O    . ASP   B 2 127 ? -19.92985 -29.68097 -20.77566 1.000 18.76645 ? 1179 ASP   B O    1 
ATOM   3174 C  CB   . ASP   B 2 127 ? -21.77654 -31.68598 -21.93414 1.000 24.40586 ? 1179 ASP   B CB   1 
ATOM   3175 C  CG   . ASP   B 2 127 ? -23.01443 -32.57712 -21.97337 1.000 28.54606 ? 1179 ASP   B CG   1 
ATOM   3176 O  OD1  . ASP   B 2 127 ? -22.86528 -33.79107 -22.14259 1.000 30.70731 ? 1179 ASP   B OD1  1 
ATOM   3177 O  OD2  . ASP   B 2 127 ? -24.14650 -32.07029 -21.81434 1.000 35.49372 ? 1179 ASP   B OD2  1 
ATOM   3178 N  N    . HIS   B 2 128 ? -18.59466 -31.45689 -20.37992 1.000 22.24853 ? 1180 HIS   B N    1 
ATOM   3179 C  CA   . HIS   B 2 128 ? -17.38176 -30.64574 -20.34870 1.000 22.39552 ? 1180 HIS   B CA   1 
ATOM   3180 C  C    . HIS   B 2 128 ? -16.82071 -30.38441 -21.74062 1.000 22.96406 ? 1180 HIS   B C    1 
ATOM   3181 O  O    . HIS   B 2 128 ? -15.83679 -29.65627 -21.87143 1.000 23.73761 ? 1180 HIS   B O    1 
ATOM   3182 C  CB   . HIS   B 2 128 ? -16.30372 -31.31178 -19.47877 1.000 24.76839 ? 1180 HIS   B CB   1 
ATOM   3183 C  CG   . HIS   B 2 128 ? -16.12053 -32.77370 -19.75904 1.000 28.69044 ? 1180 HIS   B CG   1 
ATOM   3184 N  ND1  . HIS   B 2 128 ? -15.40941 -33.24641 -20.84409 1.000 30.43843 ? 1180 HIS   B ND1  1 
ATOM   3185 C  CD2  . HIS   B 2 128 ? -16.58543 -33.87088 -19.10927 1.000 29.86794 ? 1180 HIS   B CD2  1 
ATOM   3186 C  CE1  . HIS   B 2 128 ? -15.43425 -34.56941 -20.84434 1.000 25.90200 ? 1180 HIS   B CE1  1 
ATOM   3187 N  NE2  . HIS   B 2 128 ? -16.14326 -34.97270 -19.80245 1.000 28.48202 ? 1180 HIS   B NE2  1 
ATOM   3188 N  N    . TYR   B 2 129 ? -17.41859 -30.95129 -22.78376 1.000 21.08197 ? 1181 TYR   B N    1 
ATOM   3189 C  CA   . TYR   B 2 129 ? -16.96854 -30.69198 -24.14569 1.000 21.98792 ? 1181 TYR   B CA   1 
ATOM   3190 C  C    . TYR   B 2 129 ? -18.17948 -30.82295 -25.05478 1.000 22.34384 ? 1181 TYR   B C    1 
ATOM   3191 O  O    . TYR   B 2 129 ? -19.00538 -31.71709 -24.84899 1.000 22.98807 ? 1181 TYR   B O    1 
ATOM   3192 C  CB   . TYR   B 2 129 ? -15.85740 -31.67276 -24.55781 1.000 22.98116 ? 1181 TYR   B CB   1 
ATOM   3193 C  CG   . TYR   B 2 129 ? -15.37335 -31.50644 -25.97976 1.000 23.08047 ? 1181 TYR   B CG   1 
ATOM   3194 C  CD1  . TYR   B 2 129 ? -14.34144 -30.63125 -26.28253 1.000 22.60478 ? 1181 TYR   B CD1  1 
ATOM   3195 C  CD2  . TYR   B 2 129 ? -15.94920 -32.22531 -27.02492 1.000 25.68894 ? 1181 TYR   B CD2  1 
ATOM   3196 C  CE1  . TYR   B 2 129 ? -13.89739 -30.46295 -27.58748 1.000 25.10636 ? 1181 TYR   B CE1  1 
ATOM   3197 C  CE2  . TYR   B 2 129 ? -15.50015 -32.07100 -28.34487 1.000 26.88133 ? 1181 TYR   B CE2  1 
ATOM   3198 C  CZ   . TYR   B 2 129 ? -14.47224 -31.18183 -28.61165 1.000 29.81955 ? 1181 TYR   B CZ   1 
ATOM   3199 O  OH   . TYR   B 2 129 ? -14.00919 -31.01553 -29.90359 1.000 25.57639 ? 1181 TYR   B OH   1 
ATOM   3200 N  N    . VAL   B 2 130 ? -18.28853 -29.92978 -26.04462 1.000 21.77400 ? 1182 VAL   B N    1 
ATOM   3201 C  CA   . VAL   B 2 130 ? -19.40148 -29.92874 -26.98968 1.000 22.12783 ? 1182 VAL   B CA   1 
ATOM   3202 C  C    . VAL   B 2 130 ? -18.88845 -29.58241 -28.38058 1.000 23.11276 ? 1182 VAL   B C    1 
ATOM   3203 O  O    . VAL   B 2 130 ? -17.90553 -28.85126 -28.53239 1.000 24.66461 ? 1182 VAL   B O    1 
ATOM   3204 C  CB   . VAL   B 2 130 ? -20.51863 -28.92895 -26.58555 1.000 21.58698 ? 1182 VAL   B CB   1 
ATOM   3205 C  CG1  . VAL   B 2 130 ? -21.36262 -29.48327 -25.44870 1.000 18.45726 ? 1182 VAL   B CG1  1 
ATOM   3206 C  CG2  . VAL   B 2 130 ? -19.90081 -27.60395 -26.19026 1.000 21.36498 ? 1182 VAL   B CG2  1 
ATOM   3207 N  N    . GLU   B 2 131 ? -19.57333 -30.11430 -29.40472 1.000 23.03391 ? 1183 GLU   B N    1 
ATOM   3208 C  CA   . GLU   B 2 131 ? -19.34730 -29.76001 -30.80364 1.000 26.19251 ? 1183 GLU   B CA   1 
ATOM   3209 C  C    . GLU   B 2 131 ? -20.68627 -29.65304 -31.50269 1.000 23.43307 ? 1183 GLU   B C    1 
ATOM   3210 O  O    . GLU   B 2 131 ? -21.64921 -30.30523 -31.10487 1.000 24.91509 ? 1183 GLU   B O    1 
ATOM   3211 C  CB   . GLU   B 2 131 ? -18.53413 -30.81076 -31.57880 1.000 27.44384 ? 1183 GLU   B CB   1 
ATOM   3212 C  CG   . GLU   B 2 131 ? -17.20611 -31.20171 -30.99080 1.000 24.70967 ? 1183 GLU   B CG   1 
ATOM   3213 C  CD   . GLU   B 2 131 ? -16.47494 -32.20446 -31.87995 1.000 26.62538 ? 1183 GLU   B CD   1 
ATOM   3214 O  OE1  . GLU   B 2 131 ? -17.10682 -32.80536 -32.80310 1.000 22.78418 ? 1183 GLU   B OE1  1 
ATOM   3215 O  OE2  . GLU   B 2 131 ? -15.26693 -32.39135 -31.65092 1.000 23.86592 ? 1183 GLU   B OE2  1 
ATOM   3216 N  N    . PHE   B 2 132 ? -20.73531 -28.85184 -32.56855 1.000 24.06218 ? 1184 PHE   B N    1 
ATOM   3217 C  CA   . PHE   B 2 132 ? -21.88726 -28.87982 -33.46361 1.000 26.20518 ? 1184 PHE   B CA   1 
ATOM   3218 C  C    . PHE   B 2 132 ? -21.87506 -30.13765 -34.32485 1.000 24.64499 ? 1184 PHE   B C    1 
ATOM   3219 O  O    . PHE   B 2 132 ? -20.82097 -30.71247 -34.59790 1.000 25.25578 ? 1184 PHE   B O    1 
ATOM   3220 C  CB   . PHE   B 2 132 ? -21.88836 -27.66164 -34.39238 1.000 23.68018 ? 1184 PHE   B CB   1 
ATOM   3221 C  CG   . PHE   B 2 132 ? -22.24555 -26.37381 -33.71116 1.000 23.54919 ? 1184 PHE   B CG   1 
ATOM   3222 C  CD1  . PHE   B 2 132 ? -23.54160 -26.15906 -33.24219 1.000 24.72250 ? 1184 PHE   B CD1  1 
ATOM   3223 C  CD2  . PHE   B 2 132 ? -21.29868 -25.36673 -33.55892 1.000 23.19798 ? 1184 PHE   B CD2  1 
ATOM   3224 C  CE1  . PHE   B 2 132 ? -23.88779 -24.94422 -32.61098 1.000 23.15927 ? 1184 PHE   B CE1  1 
ATOM   3225 C  CE2  . PHE   B 2 132 ? -21.63686 -24.14788 -32.93971 1.000 27.69652 ? 1184 PHE   B CE2  1 
ATOM   3226 C  CZ   . PHE   B 2 132 ? -22.92592 -23.94413 -32.46374 1.000 22.44688 ? 1184 PHE   B CZ   1 
ATOM   3227 N  N    . SER   B 2 133 ? -23.06098 -30.55971 -34.77199 1.000 27.46674 ? 1185 SER   B N    1 
ATOM   3228 C  CA   . SER   B 2 133 ? -23.09381 -31.48850 -35.89217 1.000 29.25868 ? 1185 SER   B CA   1 
ATOM   3229 C  C    . SER   B 2 133 ? -22.45383 -30.80020 -37.09701 1.000 30.94944 ? 1185 SER   B C    1 
ATOM   3230 O  O    . SER   B 2 133 ? -22.30098 -29.57717 -37.13077 1.000 26.40348 ? 1185 SER   B O    1 
ATOM   3231 C  CB   . SER   B 2 133 ? -24.52474 -31.94862 -36.19534 1.000 28.30614 ? 1185 SER   B CB   1 
ATOM   3232 O  OG   . SER   B 2 133 ? -25.40886 -30.84870 -36.36218 1.000 27.50051 ? 1185 SER   B OG   1 
ATOM   3233 N  N    . LYS   B 2 134 ? -22.07968 -31.59896 -38.09614 1.000 26.15968 ? 1186 LYS   B N    1 
ATOM   3234 C  CA   A LYS   B 2 134 ? -21.16767 -31.16465 -39.15201 0.391 29.45752 ? 1186 LYS   B CA   1 
ATOM   3235 C  CA   B LYS   B 2 134 ? -21.17668 -31.12566 -39.13600 0.609 29.42972 ? 1186 LYS   B CA   1 
ATOM   3236 C  C    . LYS   B 2 134 ? -21.87765 -30.76850 -40.44197 1.000 35.04202 ? 1186 LYS   B C    1 
ATOM   3237 O  O    . LYS   B 2 134 ? -21.60175 -29.70936 -41.00775 1.000 33.86323 ? 1186 LYS   B O    1 
ATOM   3238 C  CB   A LYS   B 2 134 ? -20.15252 -32.27447 -39.44716 0.391 28.46537 ? 1186 LYS   B CB   1 
ATOM   3239 C  CB   B LYS   B 2 134 ? -20.08654 -32.16948 -39.38114 0.609 28.42170 ? 1186 LYS   B CB   1 
ATOM   3240 C  CG   A LYS   B 2 134 ? -19.33153 -32.73060 -38.24520 0.391 29.36545 ? 1186 LYS   B CG   1 
ATOM   3241 C  CG   B LYS   B 2 134 ? -19.15358 -32.34059 -38.18712 0.609 29.17279 ? 1186 LYS   B CG   1 
ATOM   3242 C  CD   A LYS   B 2 134 ? -18.23767 -31.73453 -37.91195 0.391 28.20446 ? 1186 LYS   B CD   1 
ATOM   3243 C  CD   B LYS   B 2 134 ? -18.03345 -33.30339 -38.50924 0.609 27.25773 ? 1186 LYS   B CD   1 
ATOM   3244 C  CE   A LYS   B 2 134 ? -17.33167 -32.24663 -36.79200 0.391 27.27130 ? 1186 LYS   B CE   1 
ATOM   3245 C  CE   B LYS   B 2 134 ? -16.85852 -33.15643 -37.54615 0.609 29.53800 ? 1186 LYS   B CE   1 
ATOM   3246 N  NZ   A LYS   B 2 134 ? -16.58250 -33.48147 -37.16619 0.391 29.12595 ? 1186 LYS   B NZ   1 
ATOM   3247 N  NZ   B LYS   B 2 134 ? -17.15053 -33.67472 -36.18526 0.609 28.45643 ? 1186 LYS   B NZ   1 
ATOM   3248 N  N    . HIS   B 2 135 ? -22.77252 -31.61451 -40.94218 1.000 34.73652 ? 1187 HIS   B N    1 
ATOM   3249 C  CA   . HIS   B 2 135 ? -23.41349 -31.28435 -42.21415 1.000 35.12262 ? 1187 HIS   B CA   1 
ATOM   3250 C  C    . HIS   B 2 135 ? -24.45664 -30.19452 -42.00300 1.000 38.87329 ? 1187 HIS   B C    1 
ATOM   3251 O  O    . HIS   B 2 135 ? -24.25476 -29.03142 -42.36477 1.000 42.56020 ? 1187 HIS   B O    1 
ATOM   3252 C  CB   . HIS   B 2 135 ? -24.04831 -32.52431 -42.84742 1.000 41.08292 ? 1187 HIS   B CB   1 
ATOM   3253 C  CG   . HIS   B 2 135 ? -24.68227 -32.24313 -44.17240 1.000 44.14574 ? 1187 HIS   B CG   1 
ATOM   3254 N  ND1  . HIS   B 2 135 ? -23.94424 -31.96583 -45.30231 1.000 50.00706 ? 1187 HIS   B ND1  1 
ATOM   3255 C  CD2  . HIS   B 2 135 ? -25.98326 -32.14122 -44.53545 1.000 47.91642 ? 1187 HIS   B CD2  1 
ATOM   3256 C  CE1  . HIS   B 2 135 ? -24.76321 -31.73274 -46.31331 1.000 43.91762 ? 1187 HIS   B CE1  1 
ATOM   3257 N  NE2  . HIS   B 2 135 ? -26.00523 -31.82797 -45.87239 1.000 51.18302 ? 1187 HIS   B NE2  1 
ATOM   3258 N  N    . SER   B 2 136 ? -25.57762 -30.56676 -41.41513 1.000 35.88215 ? 1188 SER   B N    1 
ATOM   3259 C  CA   . SER   B 2 136 ? -26.59476 -29.62497 -40.99801 1.000 38.63447 ? 1188 SER   B CA   1 
ATOM   3260 C  C    . SER   B 2 136 ? -26.35588 -29.32422 -39.52294 1.000 34.93735 ? 1188 SER   B C    1 
ATOM   3261 O  O    . SER   B 2 136 ? -26.40081 -30.23138 -38.68511 1.000 38.60281 ? 1188 SER   B O    1 
ATOM   3262 C  CB   . SER   B 2 136 ? -27.98367 -30.21309 -41.23720 1.000 38.02973 ? 1188 SER   B CB   1 
ATOM   3263 O  OG   . SER   B 2 136 ? -28.98681 -29.27027 -40.93707 1.000 52.10948 ? 1188 SER   B OG   1 
ATOM   3264 N  N    . GLN   B 2 137 ? -26.08005 -28.06824 -39.20669 1.000 31.30749 ? 1189 GLN   B N    1 
ATOM   3265 C  CA   . GLN   B 2 137 ? -25.68616 -27.71245 -37.84260 1.000 30.88542 ? 1189 GLN   B CA   1 
ATOM   3266 C  C    . GLN   B 2 137 ? -26.91624 -27.45477 -36.96962 1.000 31.27312 ? 1189 GLN   B C    1 
ATOM   3267 O  O    . GLN   B 2 137 ? -27.14240 -26.36589 -36.45542 1.000 34.08203 ? 1189 GLN   B O    1 
ATOM   3268 C  CB   . GLN   B 2 137 ? -24.74731 -26.51433 -37.86532 1.000 31.53787 ? 1189 GLN   B CB   1 
ATOM   3269 C  CG   . GLN   B 2 137 ? -23.48123 -26.79103 -38.65931 1.000 29.16308 ? 1189 GLN   B CG   1 
ATOM   3270 C  CD   . GLN   B 2 137 ? -22.30936 -25.94897 -38.19308 1.000 27.26716 ? 1189 GLN   B CD   1 
ATOM   3271 O  OE1  . GLN   B 2 137 ? -22.31250 -24.72495 -38.33585 1.000 30.45962 ? 1189 GLN   B OE1  1 
ATOM   3272 N  NE2  . GLN   B 2 137 ? -21.30331 -26.60096 -37.62215 1.000 30.58478 ? 1189 GLN   B NE2  1 
ATOM   3273 N  N    . ASP   B 2 138 ? -27.71012 -28.50690 -36.79486 1.000 27.90782 ? 1190 ASP   B N    1 
ATOM   3274 C  CA   . ASP   B 2 138 ? -28.93718 -28.42619 -36.01991 1.000 29.81868 ? 1190 ASP   B CA   1 
ATOM   3275 C  C    . ASP   B 2 138 ? -28.85515 -29.22143 -34.72706 1.000 26.38905 ? 1190 ASP   B C    1 
ATOM   3276 O  O    . ASP   B 2 138 ? -29.85118 -29.30768 -34.00513 1.000 30.85316 ? 1190 ASP   B O    1 
ATOM   3277 C  CB   . ASP   B 2 138 ? -30.12507 -28.91618 -36.85907 1.000 33.55616 ? 1190 ASP   B CB   1 
ATOM   3278 C  CG   . ASP   B 2 138 ? -29.96087 -30.35407 -37.30433 1.000 35.94768 ? 1190 ASP   B CG   1 
ATOM   3279 O  OD1  . ASP   B 2 138 ? -28.88882 -30.93400 -37.02938 1.000 35.14725 ? 1190 ASP   B OD1  1 
ATOM   3280 O  OD2  . ASP   B 2 138 ? -30.89077 -30.90507 -37.92449 1.000 43.06422 ? 1190 ASP   B OD2  1 
ATOM   3281 N  N    . ARG   B 2 139 ? -27.70409 -29.81634 -34.41911 1.000 25.81029 ? 1191 ARG   B N    1 
ATOM   3282 C  CA   . ARG   B 2 139 ? -27.56307 -30.56956 -33.18724 1.000 25.85893 ? 1191 ARG   B CA   1 
ATOM   3283 C  C    . ARG   B 2 139 ? -26.23215 -30.23352 -32.52811 1.000 27.76214 ? 1191 ARG   B C    1 
ATOM   3284 O  O    . ARG   B 2 139 ? -25.30317 -29.73029 -33.15996 1.000 26.08069 ? 1191 ARG   B O    1 
ATOM   3285 C  CB   . ARG   B 2 139 ? -27.70187 -32.07953 -33.43853 1.000 30.51110 ? 1191 ARG   B CB   1 
ATOM   3286 C  CG   . ARG   B 2 139 ? -29.17381 -32.52369 -33.55470 1.000 30.15334 ? 1191 ARG   B CG   1 
ATOM   3287 C  CD   . ARG   B 2 139 ? -29.29361 -33.95461 -34.03397 1.000 38.56048 ? 1191 ARG   B CD   1 
ATOM   3288 N  NE   . ARG   B 2 139 ? -28.84652 -34.08930 -35.41698 1.000 46.52560 ? 1191 ARG   B NE   1 
ATOM   3289 C  CZ   . ARG   B 2 139 ? -28.55435 -35.24415 -36.01118 1.000 51.50527 ? 1191 ARG   B CZ   1 
ATOM   3290 N  NH1  . ARG   B 2 139 ? -28.59424 -36.39328 -35.35140 1.000 49.94281 ? 1191 ARG   B NH1  1 
ATOM   3291 N  NH2  . ARG   B 2 139 ? -28.21528 -35.24486 -37.29916 1.000 40.41010 ? 1191 ARG   B NH2  1 
ATOM   3292 N  N    . VAL   B 2 140 ? -26.17118 -30.49776 -31.22415 1.000 21.99382 ? 1192 VAL   B N    1 
ATOM   3293 C  CA   . VAL   B 2 140 ? -24.96425 -30.34976 -30.42506 1.000 22.15204 ? 1192 VAL   B CA   1 
ATOM   3294 C  C    . VAL   B 2 140 ? -24.65911 -31.71684 -29.84830 1.000 24.19564 ? 1192 VAL   B C    1 
ATOM   3295 O  O    . VAL   B 2 140 ? -25.57405 -32.41103 -29.39248 1.000 24.53945 ? 1192 VAL   B O    1 
ATOM   3296 C  CB   . VAL   B 2 140 ? -25.15043 -29.31500 -29.29287 1.000 22.75987 ? 1192 VAL   B CB   1 
ATOM   3297 C  CG1  . VAL   B 2 140 ? -23.98548 -29.38704 -28.31482 1.000 20.96541 ? 1192 VAL   B CG1  1 
ATOM   3298 C  CG2  . VAL   B 2 140 ? -25.34657 -27.90792 -29.86562 1.000 21.32265 ? 1192 VAL   B CG2  1 
ATOM   3299 N  N    . ILE   B 2 141 ? -23.39106 -32.12368 -29.87531 1.000 21.88175 ? 1193 ILE   B N    1 
ATOM   3300 C  CA   . ILE   B 2 141 ? -23.01194 -33.37375 -29.22452 1.000 22.17156 ? 1193 ILE   B CA   1 
ATOM   3301 C  C    . ILE   B 2 141 ? -22.08205 -33.04186 -28.07241 1.000 23.80452 ? 1193 ILE   B C    1 
ATOM   3302 O  O    . ILE   B 2 141 ? -21.05712 -32.37670 -28.26223 1.000 25.04303 ? 1193 ILE   B O    1 
ATOM   3303 C  CB   . ILE   B 2 141 ? -22.36977 -34.39149 -30.18168 1.000 22.41827 ? 1193 ILE   B CB   1 
ATOM   3304 C  CG1  . ILE   B 2 141 ? -22.10765 -35.68361 -29.40091 1.000 21.49479 ? 1193 ILE   B CG1  1 
ATOM   3305 C  CG2  . ILE   B 2 141 ? -21.07880 -33.84922 -30.79951 1.000 23.13265 ? 1193 ILE   B CG2  1 
ATOM   3306 C  CD1  . ILE   B 2 141 ? -21.83845 -36.91041 -30.27013 1.000 22.59993 ? 1193 ILE   B CD1  1 
ATOM   3307 N  N    . GLY   B 2 142 ? -22.45205 -33.49613 -26.87952 1.000 23.68561 ? 1194 GLY   B N    1 
ATOM   3308 C  CA   . GLY   B 2 142 ? -21.67615 -33.22826 -25.68442 1.000 20.46303 ? 1194 GLY   B CA   1 
ATOM   3309 C  C    . GLY   B 2 142 ? -21.03503 -34.48529 -25.13563 1.000 21.38073 ? 1194 GLY   B C    1 
ATOM   3310 O  O    . GLY   B 2 142 ? -21.46888 -35.60128 -25.44486 1.000 23.43445 ? 1194 GLY   B O    1 
ATOM   3311 N  N    . THR   B 2 143 ? -19.98909 -34.31831 -24.33854 1.000 21.33137 ? 1195 THR   B N    1 
ATOM   3312 C  CA   . THR   B 2 143 ? -19.29099 -35.42734 -23.71171 1.000 21.61154 ? 1195 THR   B CA   1 
ATOM   3313 C  C    . THR   B 2 143 ? -19.29610 -35.21863 -22.20767 1.000 24.92759 ? 1195 THR   B C    1 
ATOM   3314 O  O    . THR   B 2 143 ? -18.94226 -34.13367 -21.72445 1.000 20.75914 ? 1195 THR   B O    1 
ATOM   3315 C  CB   . THR   B 2 143 ? -17.85195 -35.54407 -24.20065 1.000 24.23064 ? 1195 THR   B CB   1 
ATOM   3316 O  OG1  . THR   B 2 143 ? -17.84986 -35.61580 -25.62967 1.000 25.29083 ? 1195 THR   B OG1  1 
ATOM   3317 C  CG2  . THR   B 2 143 ? -17.18483 -36.80811 -23.59886 1.000 20.51378 ? 1195 THR   B CG2  1 
ATOM   3318 N  N    . LYS   B 2 144 ? -19.70301 -36.25681 -21.48189 1.000 22.84957 ? 1196 LYS   B N    1 
ATOM   3319 C  CA   . LYS   B 2 144 ? -19.57708 -36.32207 -20.02689 1.000 25.98220 ? 1196 LYS   B CA   1 
ATOM   3320 C  C    . LYS   B 2 144 ? -18.84194 -37.62004 -19.70610 1.000 22.37975 ? 1196 LYS   B C    1 
ATOM   3321 O  O    . LYS   B 2 144 ? -19.45681 -38.69113 -19.66533 1.000 28.31050 ? 1196 LYS   B O    1 
ATOM   3322 C  CB   . LYS   B 2 144 ? -20.92913 -36.28337 -19.33196 1.000 24.20808 ? 1196 LYS   B CB   1 
ATOM   3323 C  CG   . LYS   B 2 144 ? -20.79222 -36.22064 -17.80194 1.000 27.46438 ? 1196 LYS   B CG   1 
ATOM   3324 C  CD   . LYS   B 2 144 ? -21.99818 -36.84891 -17.13612 1.000 33.20616 ? 1196 LYS   B CD   1 
ATOM   3325 C  CE   . LYS   B 2 144 ? -21.89826 -36.79219 -15.62611 1.000 39.84697 ? 1196 LYS   B CE   1 
ATOM   3326 N  NZ   . LYS   B 2 144 ? -23.16524 -37.29745 -15.03227 1.000 50.34749 ? 1196 LYS   B NZ   1 
ATOM   3327 N  N    . GLY   B 2 145 ? -17.54197 -37.51693 -19.48701 1.000 20.86087 ? 1197 GLY   B N    1 
ATOM   3328 C  CA   . GLY   B 2 145 ? -16.74184 -38.70088 -19.22519 1.000 26.51728 ? 1197 GLY   B CA   1 
ATOM   3329 C  C    . GLY   B 2 145 ? -16.83766 -39.64067 -20.40637 1.000 27.53152 ? 1197 GLY   B C    1 
ATOM   3330 O  O    . GLY   B 2 145 ? -16.48564 -39.28041 -21.53428 1.000 27.44393 ? 1197 GLY   B O    1 
ATOM   3331 N  N    . ASP   B 2 146 ? -17.34952 -40.85077 -20.17163 1.000 25.95136 ? 1198 ASP   B N    1 
ATOM   3332 C  CA   . ASP   B 2 146 ? -17.43134 -41.86759 -21.21383 1.000 27.65053 ? 1198 ASP   B CA   1 
ATOM   3333 C  C    . ASP   B 2 146 ? -18.68531 -41.75658 -22.07187 1.000 28.04480 ? 1198 ASP   B C    1 
ATOM   3334 O  O    . ASP   B 2 146 ? -18.83216 -42.53042 -23.02703 1.000 28.51386 ? 1198 ASP   B O    1 
ATOM   3335 C  CB   . ASP   B 2 146 ? -17.39321 -43.26470 -20.59709 1.000 28.48937 ? 1198 ASP   B CB   1 
ATOM   3336 C  CG   . ASP   B 2 146 ? -16.12321 -43.54069 -19.83707 1.000 29.89500 ? 1198 ASP   B CG   1 
ATOM   3337 O  OD1  . ASP   B 2 146 ? -15.06827 -42.91151 -20.11489 1.000 31.14466 ? 1198 ASP   B OD1  1 
ATOM   3338 O  OD2  . ASP   B 2 146 ? -16.18215 -44.41786 -18.95724 1.000 33.34000 ? 1198 ASP   B OD2  1 
ATOM   3339 N  N    . ILE   B 2 147 ? -19.58944 -40.83375 -21.74975 1.000 22.57557 ? 1199 ILE   B N    1 
ATOM   3340 C  CA   . ILE   B 2 147 ? -20.94741 -40.80981 -22.28582 1.000 21.08816 ? 1199 ILE   B CA   1 
ATOM   3341 C  C    . ILE   B 2 147 ? -21.10250 -39.67964 -23.29161 1.000 28.14781 ? 1199 ILE   B C    1 
ATOM   3342 O  O    . ILE   B 2 147 ? -20.61664 -38.56463 -23.06637 1.000 27.94843 ? 1199 ILE   B O    1 
ATOM   3343 C  CB   . ILE   B 2 147 ? -21.96850 -40.62815 -21.14784 1.000 27.12950 ? 1199 ILE   B CB   1 
ATOM   3344 C  CG1  . ILE   B 2 147 ? -21.79242 -41.73233 -20.10304 1.000 28.22684 ? 1199 ILE   B CG1  1 
ATOM   3345 C  CG2  . ILE   B 2 147 ? -23.36547 -40.57321 -21.72090 1.000 26.02428 ? 1199 ILE   B CG2  1 
ATOM   3346 C  CD1  . ILE   B 2 147 ? -22.49253 -41.43566 -18.79302 1.000 33.23611 ? 1199 ILE   B CD1  1 
ATOM   3347 N  N    . ALA   B 2 148 ? -21.82640 -39.95253 -24.37470 1.000 21.90880 ? 1200 ALA   B N    1 
ATOM   3348 C  CA   . ALA   B 2 148 ? -22.14347 -38.95737 -25.38753 1.000 22.76872 ? 1200 ALA   B CA   1 
ATOM   3349 C  C    . ALA   B 2 148 ? -23.59853 -38.53257 -25.26653 1.000 24.73543 ? 1200 ALA   B C    1 
ATOM   3350 O  O    . ALA   B 2 148 ? -24.48744 -39.36872 -25.08474 1.000 24.03697 ? 1200 ALA   B O    1 
ATOM   3351 C  CB   . ALA   B 2 148 ? -21.89033 -39.50708 -26.79562 1.000 22.01451 ? 1200 ALA   B CB   1 
ATOM   3352 N  N    . HIS   B 2 149 ? -23.83668 -37.23058 -25.36830 1.000 23.13878 ? 1201 HIS   B N    1 
ATOM   3353 C  CA   . HIS   B 2 149 ? -25.18275 -36.66475 -25.36526 1.000 25.17277 ? 1201 HIS   B CA   1 
ATOM   3354 C  C    . HIS   B 2 149 ? -25.39477 -35.89153 -26.65713 1.000 24.49685 ? 1201 HIS   B C    1 
ATOM   3355 O  O    . HIS   B 2 149 ? -24.51884 -35.13134 -27.08194 1.000 26.42887 ? 1201 HIS   B O    1 
ATOM   3356 C  CB   . HIS   B 2 149 ? -25.40893 -35.72100 -24.17410 1.000 25.41737 ? 1201 HIS   B CB   1 
ATOM   3357 C  CG   . HIS   B 2 149 ? -25.30692 -36.38824 -22.83722 1.000 27.19053 ? 1201 HIS   B CG   1 
ATOM   3358 N  ND1  . HIS   B 2 149 ? -24.60205 -35.83835 -21.79008 1.000 24.04248 ? 1201 HIS   B ND1  1 
ATOM   3359 C  CD2  . HIS   B 2 149 ? -25.83081 -37.54939 -22.37147 1.000 26.08153 ? 1201 HIS   B CD2  1 
ATOM   3360 C  CE1  . HIS   B 2 149 ? -24.68601 -36.63656 -20.73623 1.000 27.81683 ? 1201 HIS   B CE1  1 
ATOM   3361 N  NE2  . HIS   B 2 149 ? -25.42886 -37.67959 -21.06247 1.000 24.68926 ? 1201 HIS   B NE2  1 
ATOM   3362 N  N    . ILE   B 2 150 ? -26.55272 -36.08055 -27.28123 1.000 22.31793 ? 1202 ILE   B N    1 
ATOM   3363 C  CA   . ILE   B 2 150 ? -26.91174 -35.34637 -28.48711 1.000 23.50158 ? 1202 ILE   B CA   1 
ATOM   3364 C  C    . ILE   B 2 150 ? -28.13486 -34.49757 -28.18801 1.000 24.14120 ? 1202 ILE   B C    1 
ATOM   3365 O  O    . ILE   B 2 150 ? -29.15282 -35.02179 -27.72417 1.000 26.28227 ? 1202 ILE   B O    1 
ATOM   3366 C  CB   . ILE   B 2 150 ? -27.17356 -36.28818 -29.67330 1.000 26.41788 ? 1202 ILE   B CB   1 
ATOM   3367 C  CG1  . ILE   B 2 150 ? -25.89545 -37.05895 -30.03038 1.000 25.85201 ? 1202 ILE   B CG1  1 
ATOM   3368 C  CG2  . ILE   B 2 150 ? -27.68859 -35.50201 -30.86918 1.000 28.23058 ? 1202 ILE   B CG2  1 
ATOM   3369 C  CD1  . ILE   B 2 150 ? -26.08427 -38.00875 -31.20657 1.000 30.89674 ? 1202 ILE   B CD1  1 
ATOM   3370 N  N    . TYR   B 2 151 ? -28.03701 -33.19451 -28.46876 1.000 23.96096 ? 1203 TYR   B N    1 
ATOM   3371 C  CA   . TYR   B 2 151 ? -29.09514 -32.23669 -28.18264 1.000 24.96697 ? 1203 TYR   B CA   1 
ATOM   3372 C  C    . TYR   B 2 151 ? -29.59615 -31.58151 -29.45854 1.000 24.46302 ? 1203 TYR   B C    1 
ATOM   3373 O  O    . TYR   B 2 151 ? -28.84312 -31.37824 -30.41246 1.000 24.35840 ? 1203 TYR   B O    1 
ATOM   3374 C  CB   . TYR   B 2 151 ? -28.61733 -31.11781 -27.23640 1.000 23.26602 ? 1203 TYR   B CB   1 
ATOM   3375 C  CG   . TYR   B 2 151 ? -28.03133 -31.61198 -25.95146 1.000 25.79174 ? 1203 TYR   B CG   1 
ATOM   3376 C  CD1  . TYR   B 2 151 ? -28.84336 -31.88429 -24.85256 1.000 22.77231 ? 1203 TYR   B CD1  1 
ATOM   3377 C  CD2  . TYR   B 2 151 ? -26.66232 -31.81684 -25.83143 1.000 25.50616 ? 1203 TYR   B CD2  1 
ATOM   3378 C  CE1  . TYR   B 2 151 ? -28.29437 -32.34345 -23.67062 1.000 26.67093 ? 1203 TYR   B CE1  1 
ATOM   3379 C  CE2  . TYR   B 2 151 ? -26.11032 -32.27999 -24.65649 1.000 21.88633 ? 1203 TYR   B CE2  1 
ATOM   3380 C  CZ   . TYR   B 2 151 ? -26.92235 -32.53830 -23.58258 1.000 24.06563 ? 1203 TYR   B CZ   1 
ATOM   3381 O  OH   . TYR   B 2 151 ? -26.35936 -33.00645 -22.41364 1.000 23.65710 ? 1203 TYR   B OH   1 
ATOM   3382 N  N    . ASP   B 2 152 ? -30.86619 -31.20767 -29.43754 1.000 26.89985 ? 1204 ASP   B N    1 
ATOM   3383 C  CA   . ASP   B 2 152 ? -31.44824 -30.38954 -30.49042 1.000 26.78818 ? 1204 ASP   B CA   1 
ATOM   3384 C  C    . ASP   B 2 152 ? -31.15443 -28.91556 -30.22912 1.000 30.58814 ? 1204 ASP   B C    1 
ATOM   3385 O  O    . ASP   B 2 152 ? -31.34655 -28.41779 -29.11604 1.000 28.77742 ? 1204 ASP   B O    1 
ATOM   3386 C  CB   . ASP   B 2 152 ? -32.95620 -30.62071 -30.56354 1.000 27.18632 ? 1204 ASP   B CB   1 
ATOM   3387 C  CG   . ASP   B 2 152 ? -33.61725 -29.78059 -31.62842 1.000 33.57046 ? 1204 ASP   B CG   1 
ATOM   3388 O  OD1  . ASP   B 2 152 ? -33.39115 -30.05734 -32.81946 1.000 39.06155 ? 1204 ASP   B OD1  1 
ATOM   3389 O  OD2  . ASP   B 2 152 ? -34.34638 -28.83475 -31.27628 1.000 36.04755 ? 1204 ASP   B OD2  1 
ATOM   3390 N  N    . ILE   B 2 153 ? -30.71546 -28.20531 -31.26497 1.000 23.95905 ? 1205 ILE   B N    1 
ATOM   3391 C  CA   . ILE   B 2 153 ? -30.32264 -26.81730 -31.06568 1.000 29.55887 ? 1205 ILE   B CA   1 
ATOM   3392 C  C    . ILE   B 2 153 ? -31.52577 -25.94350 -30.74258 1.000 32.47963 ? 1205 ILE   B C    1 
ATOM   3393 O  O    . ILE   B 2 153 ? -31.41192 -24.96963 -29.98839 1.000 31.98160 ? 1205 ILE   B O    1 
ATOM   3394 C  CB   . ILE   B 2 153 ? -29.57564 -26.29197 -32.29854 1.000 32.92855 ? 1205 ILE   B CB   1 
ATOM   3395 C  CG1  . ILE   B 2 153 ? -28.10559 -26.70380 -32.25354 1.000 28.12389 ? 1205 ILE   B CG1  1 
ATOM   3396 C  CG2  . ILE   B 2 153 ? -29.73082 -24.77897 -32.40926 1.000 33.59918 ? 1205 ILE   B CG2  1 
ATOM   3397 C  CD1  . ILE   B 2 153 ? -27.32860 -26.14149 -33.40939 1.000 28.23846 ? 1205 ILE   B CD1  1 
ATOM   3398 N  N    . GLN   B 2 154 ? -32.68470 -26.23853 -31.33370 1.000 27.87726 ? 1206 GLN   B N    1 
ATOM   3399 C  CA   . GLN   B 2 154 ? -33.83382 -25.35871 -31.13560 1.000 35.66081 ? 1206 GLN   B CA   1 
ATOM   3400 C  C    . GLN   B 2 154 ? -34.42187 -25.52705 -29.74166 1.000 31.70167 ? 1206 GLN   B C    1 
ATOM   3401 O  O    . GLN   B 2 154 ? -34.57703 -24.54821 -29.00048 1.000 32.62615 ? 1206 GLN   B O    1 
ATOM   3402 C  CB   . GLN   B 2 154 ? -34.89273 -25.60764 -32.21170 1.000 37.95475 ? 1206 GLN   B CB   1 
ATOM   3403 C  CG   . GLN   B 2 154 ? -34.49972 -25.07633 -33.59458 1.000 45.45100 ? 1206 GLN   B CG   1 
ATOM   3404 C  CD   . GLN   B 2 154 ? -34.10190 -23.59528 -33.58028 1.000 65.39197 ? 1206 GLN   B CD   1 
ATOM   3405 O  OE1  . GLN   B 2 154 ? -34.73703 -22.76649 -32.91216 1.000 68.64842 ? 1206 GLN   B OE1  1 
ATOM   3406 N  NE2  . GLN   B 2 154 ? -33.03790 -23.26101 -34.31516 1.000 57.73293 ? 1206 GLN   B NE2  1 
ATOM   3407 N  N    . THR   B 2 155 ? -34.74874 -26.76016 -29.36291 1.000 28.26121 ? 1207 THR   B N    1 
ATOM   3408 C  CA   . THR   B 2 155 ? -35.36778 -27.01148 -28.06699 1.000 33.36376 ? 1207 THR   B CA   1 
ATOM   3409 C  C    . THR   B 2 155 ? -34.37282 -27.21257 -26.93598 1.000 33.47339 ? 1207 THR   B C    1 
ATOM   3410 O  O    . THR   B 2 155 ? -34.76389 -27.11684 -25.76598 1.000 30.90940 ? 1207 THR   B O    1 
ATOM   3411 C  CB   . THR   B 2 155 ? -36.25963 -28.24958 -28.12828 1.000 29.61881 ? 1207 THR   B CB   1 
ATOM   3412 O  OG1  . THR   B 2 155 ? -35.45247 -29.40843 -28.36745 1.000 31.23926 ? 1207 THR   B OG1  1 
ATOM   3413 C  CG2  . THR   B 2 155 ? -37.27958 -28.10549 -29.23430 1.000 33.85615 ? 1207 THR   B CG2  1 
ATOM   3414 N  N    . GLY   B 2 156 ? -33.10577 -27.50136 -27.24596 1.000 31.22372 ? 1208 GLY   B N    1 
ATOM   3415 C  CA   . GLY   B 2 156 ? -32.17277 -27.90144 -26.21499 1.000 28.09321 ? 1208 GLY   B CA   1 
ATOM   3416 C  C    . GLY   B 2 156 ? -32.41264 -29.27458 -25.62826 1.000 29.18506 ? 1208 GLY   B C    1 
ATOM   3417 O  O    . GLY   B 2 156 ? -31.63863 -29.69465 -24.76130 1.000 23.94877 ? 1208 GLY   B O    1 
ATOM   3418 N  N    . ASN   B 2 157 ? -33.45253 -29.98962 -26.06645 1.000 28.39385 ? 1209 ASN   B N    1 
ATOM   3419 C  CA   . ASN   B 2 157 ? -33.75140 -31.30676 -25.50872 1.000 28.81336 ? 1209 ASN   B CA   1 
ATOM   3420 C  C    . ASN   B 2 157 ? -32.64326 -32.29357 -25.81984 1.000 26.34975 ? 1209 ASN   B C    1 
ATOM   3421 O  O    . ASN   B 2 157 ? -32.05420 -32.26430 -26.89881 1.000 27.65741 ? 1209 ASN   B O    1 
ATOM   3422 C  CB   . ASN   B 2 157 ? -35.05930 -31.86482 -26.07489 1.000 27.74193 ? 1209 ASN   B CB   1 
ATOM   3423 C  CG   . ASN   B 2 157 ? -36.25742 -31.01703 -25.71880 1.000 35.50601 ? 1209 ASN   B CG   1 
ATOM   3424 O  OD1  . ASN   B 2 157 ? -36.16158 -30.08117 -24.92862 1.000 35.34297 ? 1209 ASN   B OD1  1 
ATOM   3425 N  ND2  . ASN   B 2 157 ? -37.39735 -31.34706 -26.30192 1.000 34.35561 ? 1209 ASN   B ND2  1 
ATOM   3426 N  N    . LYS   B 2 158 ? -32.38520 -33.19272 -24.87800 1.000 23.43695 ? 1210 LYS   B N    1 
ATOM   3427 C  CA   . LYS   B 2 158 ? -31.50605 -34.32356 -25.12516 1.000 26.30721 ? 1210 LYS   B CA   1 
ATOM   3428 C  C    . LYS   B 2 158 ? -32.23188 -35.32848 -26.01239 1.000 32.87784 ? 1210 LYS   B C    1 
ATOM   3429 O  O    . LYS   B 2 158 ? -33.23483 -35.92368 -25.60356 1.000 30.04428 ? 1210 LYS   B O    1 
ATOM   3430 C  CB   . LYS   B 2 158 ? -31.07504 -34.95976 -23.80526 1.000 27.68605 ? 1210 LYS   B CB   1 
ATOM   3431 C  CG   . LYS   B 2 158 ? -30.25588 -36.23263 -23.99346 1.000 30.56587 ? 1210 LYS   B CG   1 
ATOM   3432 C  CD   . LYS   B 2 158 ? -29.34491 -36.51373 -22.82446 1.000 30.45018 ? 1210 LYS   B CD   1 
ATOM   3433 C  CE   . LYS   B 2 158 ? -30.08896 -36.67707 -21.51853 1.000 39.10345 ? 1210 LYS   B CE   1 
ATOM   3434 N  NZ   . LYS   B 2 158 ? -29.10203 -36.61717 -20.38547 1.000 43.33797 ? 1210 LYS   B NZ   1 
ATOM   3435 N  N    . LEU   B 2 159 ? -31.73379 -35.51219 -27.23640 1.000 29.79689 ? 1211 LEU   B N    1 
ATOM   3436 C  CA   . LEU   B 2 159 ? -32.34862 -36.46009 -28.15861 1.000 28.83946 ? 1211 LEU   B CA   1 
ATOM   3437 C  C    . LEU   B 2 159 ? -31.85046 -37.87808 -27.91285 1.000 32.51402 ? 1211 LEU   B C    1 
ATOM   3438 O  O    . LEU   B 2 159 ? -32.61134 -38.84115 -28.05008 1.000 31.83068 ? 1211 LEU   B O    1 
ATOM   3439 C  CB   . LEU   B 2 159 ? -32.06960 -36.04679 -29.60452 1.000 27.78245 ? 1211 LEU   B CB   1 
ATOM   3440 C  CG   . LEU   B 2 159 ? -32.48474 -34.64176 -30.02828 1.000 29.85626 ? 1211 LEU   B CG   1 
ATOM   3441 C  CD1  . LEU   B 2 159 ? -32.06970 -34.35643 -31.46520 1.000 31.42085 ? 1211 LEU   B CD1  1 
ATOM   3442 C  CD2  . LEU   B 2 159 ? -33.98678 -34.44297 -29.85132 1.000 38.43215 ? 1211 LEU   B CD2  1 
ATOM   3443 N  N    . LEU   B 2 160 ? -30.58247 -38.02899 -27.54281 1.000 25.79849 ? 1212 LEU   B N    1 
ATOM   3444 C  CA   . LEU   B 2 160 ? -29.96331 -39.34293 -27.46403 1.000 28.71624 ? 1212 LEU   B CA   1 
ATOM   3445 C  C    . LEU   B 2 160 ? -28.86637 -39.34000 -26.41597 1.000 27.79485 ? 1212 LEU   B C    1 
ATOM   3446 O  O    . LEU   B 2 160 ? -28.14850 -38.35094 -26.26074 1.000 30.01131 ? 1212 LEU   B O    1 
ATOM   3447 C  CB   . LEU   B 2 160 ? -29.34819 -39.74260 -28.81207 1.000 27.41185 ? 1212 LEU   B CB   1 
ATOM   3448 C  CG   . LEU   B 2 160 ? -30.18404 -40.51652 -29.81326 1.000 41.58924 ? 1212 LEU   B CG   1 
ATOM   3449 C  CD1  . LEU   B 2 160 ? -29.33994 -40.74418 -31.06826 1.000 40.37993 ? 1212 LEU   B CD1  1 
ATOM   3450 C  CD2  . LEU   B 2 160 ? -30.64291 -41.84469 -29.20654 1.000 42.37743 ? 1212 LEU   B CD2  1 
ATOM   3451 N  N    . THR   B 2 161 ? -28.72327 -40.46111 -25.72417 1.000 27.21883 ? 1213 THR   B N    1 
ATOM   3452 C  CA   . THR   B 2 161 ? -27.53528 -40.74511 -24.94016 1.000 29.00189 ? 1213 THR   B CA   1 
ATOM   3453 C  C    . THR   B 2 161 ? -26.89609 -41.98893 -25.53236 1.000 34.76154 ? 1213 THR   B C    1 
ATOM   3454 O  O    . THR   B 2 161 ? -27.56796 -43.00798 -25.70059 1.000 33.11843 ? 1213 THR   B O    1 
ATOM   3455 C  CB   . THR   B 2 161 ? -27.86233 -40.97043 -23.46322 1.000 30.70476 ? 1213 THR   B CB   1 
ATOM   3456 O  OG1  . THR   B 2 161 ? -28.35051 -39.75560 -22.88302 1.000 29.80354 ? 1213 THR   B OG1  1 
ATOM   3457 C  CG2  . THR   B 2 161 ? -26.62231 -41.43542 -22.70924 1.000 31.05687 ? 1213 THR   B CG2  1 
ATOM   3458 N  N    . LEU   B 2 162 ? -25.61509 -41.90271 -25.86228 1.000 30.07617 ? 1214 LEU   B N    1 
ATOM   3459 C  CA   . LEU   B 2 162 ? -24.87492 -43.03051 -26.41445 1.000 32.51085 ? 1214 LEU   B CA   1 
ATOM   3460 C  C    . LEU   B 2 162 ? -23.85092 -43.47558 -25.38548 1.000 29.40895 ? 1214 LEU   B C    1 
ATOM   3461 O  O    . LEU   B 2 162 ? -22.89502 -42.74552 -25.09629 1.000 30.89423 ? 1214 LEU   B O    1 
ATOM   3462 C  CB   . LEU   B 2 162 ? -24.20189 -42.66118 -27.73534 1.000 28.43056 ? 1214 LEU   B CB   1 
ATOM   3463 C  CG   . LEU   B 2 162 ? -25.14590 -42.12809 -28.81329 1.000 32.42581 ? 1214 LEU   B CG   1 
ATOM   3464 C  CD1  . LEU   B 2 162 ? -24.40386 -41.84876 -30.10220 1.000 26.57859 ? 1214 LEU   B CD1  1 
ATOM   3465 C  CD2  . LEU   B 2 162 ? -26.29577 -43.09919 -29.04654 1.000 34.65592 ? 1214 LEU   B CD2  1 
ATOM   3466 N  N    . PHE   B 2 163 ? -24.04680 -44.67371 -24.84171 1.000 26.79302 ? 1215 PHE   B N    1 
ATOM   3467 C  CA   . PHE   B 2 163 ? -23.09678 -45.26077 -23.91377 1.000 26.39418 ? 1215 PHE   B CA   1 
ATOM   3468 C  C    . PHE   B 2 163 ? -23.39761 -46.74283 -23.77707 1.000 32.25647 ? 1215 PHE   B C    1 
ATOM   3469 O  O    . PHE   B 2 163 ? -24.55757 -47.14200 -23.65221 1.000 34.03599 ? 1215 PHE   B O    1 
ATOM   3470 C  CB   . PHE   B 2 163 ? -23.15494 -44.59503 -22.53965 1.000 28.56504 ? 1215 PHE   B CB   1 
ATOM   3471 C  CG   . PHE   B 2 163 ? -22.31691 -45.28313 -21.50974 1.000 33.03626 ? 1215 PHE   B CG   1 
ATOM   3472 C  CD1  . PHE   B 2 163 ? -20.93990 -45.27994 -21.60666 1.000 25.92846 ? 1215 PHE   B CD1  1 
ATOM   3473 C  CD2  . PHE   B 2 163 ? -22.90089 -45.93040 -20.44289 1.000 37.93929 ? 1215 PHE   B CD2  1 
ATOM   3474 C  CE1  . PHE   B 2 163 ? -20.16188 -45.90802 -20.66674 1.000 31.90091 ? 1215 PHE   B CE1  1 
ATOM   3475 C  CE2  . PHE   B 2 163 ? -22.12286 -46.56449 -19.48897 1.000 37.35304 ? 1215 PHE   B CE2  1 
ATOM   3476 C  CZ   . PHE   B 2 163 ? -20.75386 -46.55530 -19.60289 1.000 35.80851 ? 1215 PHE   B CZ   1 
ATOM   3477 N  N    . ASN   B 2 164 ? -22.35251 -47.54070 -23.80216 1.000 30.71029 ? 1216 ASN   B N    1 
ATOM   3478 C  CA   . ASN   B 2 164 ? -22.45335 -48.96376 -23.55144 1.000 30.18160 ? 1216 ASN   B CA   1 
ATOM   3479 C  C    . ASN   B 2 164 ? -21.28735 -49.37078 -22.67145 1.000 32.60684 ? 1216 ASN   B C    1 
ATOM   3480 O  O    . ASN   B 2 164 ? -20.13633 -49.35856 -23.12739 1.000 30.21261 ? 1216 ASN   B O    1 
ATOM   3481 C  CB   . ASN   B 2 164 ? -22.43218 -49.75751 -24.85059 1.000 37.13569 ? 1216 ASN   B CB   1 
ATOM   3482 C  CG   . ASN   B 2 164 ? -22.55801 -51.24657 -24.61288 1.000 41.89823 ? 1216 ASN   B CG   1 
ATOM   3483 O  OD1  . ASN   B 2 164 ? -22.00100 -51.78668 -23.65095 1.000 43.42179 ? 1216 ASN   B OD1  1 
ATOM   3484 N  ND2  . ASN   B 2 164 ? -23.31089 -51.91550 -25.47804 1.000 42.70738 ? 1216 ASN   B ND2  1 
ATOM   3485 N  N    . PRO   B 2 165 ? -21.54237 -49.76205 -21.42054 1.000 37.81106 ? 1217 PRO   B N    1 
ATOM   3486 C  CA   . PRO   B 2 165 ? -20.42439 -50.01809 -20.50253 1.000 37.58400 ? 1217 PRO   B CA   1 
ATOM   3487 C  C    . PRO   B 2 165 ? -19.57522 -51.20691 -20.91371 1.000 36.66941 ? 1217 PRO   B C    1 
ATOM   3488 O  O    . PRO   B 2 165 ? -18.38323 -51.24382 -20.58665 1.000 39.04229 ? 1217 PRO   B O    1 
ATOM   3489 C  CB   . PRO   B 2 165 ? -21.12043 -50.25543 -19.15461 1.000 38.36297 ? 1217 PRO   B CB   1 
ATOM   3490 C  CG   . PRO   B 2 165 ? -22.62242 -50.23155 -19.44769 1.000 41.81140 ? 1217 PRO   B CG   1 
ATOM   3491 C  CD   . PRO   B 2 165 ? -22.80933 -50.30530 -20.91471 1.000 41.58617 ? 1217 PRO   B CD   1 
ATOM   3492 N  N    . ASP   B 2 166 ? -20.14206 -52.17184 -21.63492 1.000 39.44686 ? 1218 ASP   B N    1 
ATOM   3493 C  CA   . ASP   B 2 166 ? -19.34790 -53.30866 -22.08209 1.000 39.52118 ? 1218 ASP   B CA   1 
ATOM   3494 C  C    . ASP   B 2 166 ? -18.39189 -52.92233 -23.19897 1.000 43.01934 ? 1218 ASP   B C    1 
ATOM   3495 O  O    . ASP   B 2 166 ? -17.30481 -53.50318 -23.30502 1.000 47.56476 ? 1218 ASP   B O    1 
ATOM   3496 C  CB   . ASP   B 2 166 ? -20.26374 -54.44068 -22.53135 1.000 44.85392 ? 1218 ASP   B CB   1 
ATOM   3497 C  CG   . ASP   B 2 166 ? -21.21374 -54.88201 -21.43549 1.000 47.17132 ? 1218 ASP   B CG   1 
ATOM   3498 O  OD1  . ASP   B 2 166 ? -20.82582 -54.80218 -20.24645 1.000 51.40076 ? 1218 ASP   B OD1  1 
ATOM   3499 O  OD2  . ASP   B 2 166 ? -22.35068 -55.29108 -21.75963 1.000 60.20154 ? 1218 ASP   B OD2  1 
ATOM   3500 N  N    . LEU   B 2 167 ? -18.75996 -51.94922 -24.03080 1.000 39.18210 ? 1219 LEU   B N    1 
ATOM   3501 C  CA   . LEU   B 2 167 ? -17.89995 -51.54990 -25.13668 1.000 39.47302 ? 1219 LEU   B CA   1 
ATOM   3502 C  C    . LEU   B 2 167 ? -16.94711 -50.41085 -24.78641 1.000 35.71905 ? 1219 LEU   B C    1 
ATOM   3503 O  O    . LEU   B 2 167 ? -16.00610 -50.15360 -25.54431 1.000 37.92526 ? 1219 LEU   B O    1 
ATOM   3504 C  CB   . LEU   B 2 167 ? -18.75093 -51.15078 -26.34965 1.000 40.43837 ? 1219 LEU   B CB   1 
ATOM   3505 C  CG   . LEU   B 2 167 ? -19.55076 -52.26975 -27.02391 1.000 36.44156 ? 1219 LEU   B CG   1 
ATOM   3506 C  CD1  . LEU   B 2 167 ? -20.34676 -51.72763 -28.17985 1.000 37.47672 ? 1219 LEU   B CD1  1 
ATOM   3507 C  CD2  . LEU   B 2 167 ? -18.63760 -53.39355 -27.49907 1.000 37.64717 ? 1219 LEU   B CD2  1 
ATOM   3508 N  N    . ALA   B 2 168 ? -17.14325 -49.74309 -23.65630 1.000 35.39273 ? 1220 ALA   B N    1 
ATOM   3509 C  CA   . ALA   B 2 168 ? -16.36841 -48.54705 -23.35803 1.000 33.54111 ? 1220 ALA   B CA   1 
ATOM   3510 C  C    . ALA   B 2 168 ? -14.87138 -48.84087 -23.35400 1.000 32.71334 ? 1220 ALA   B C    1 
ATOM   3511 O  O    . ALA   B 2 168 ? -14.41926 -49.92489 -22.96918 1.000 35.43366 ? 1220 ALA   B O    1 
ATOM   3512 C  CB   . ALA   B 2 168 ? -16.78856 -47.96636 -22.00494 1.000 28.91408 ? 1220 ALA   B CB   1 
ATOM   3513 N  N    . ASN   B 2 169 ? -14.09947 -47.84869 -23.78977 1.000 24.86284 ? 1221 ASN   B N    1 
ATOM   3514 C  CA   . ASN   B 2 169 ? -12.65548 -47.84555 -23.63070 1.000 24.54173 ? 1221 ASN   B CA   1 
ATOM   3515 C  C    . ASN   B 2 169 ? -12.19565 -46.98571 -22.46151 1.000 25.95205 ? 1221 ASN   B C    1 
ATOM   3516 O  O    . ASN   B 2 169 ? -11.03666 -47.09465 -22.04847 1.000 24.24434 ? 1221 ASN   B O    1 
ATOM   3517 C  CB   . ASN   B 2 169 ? -11.98247 -47.35822 -24.92257 1.000 31.37403 ? 1221 ASN   B CB   1 
ATOM   3518 C  CG   . ASN   B 2 169 ? -12.02428 -48.39602 -26.02376 1.000 29.04122 ? 1221 ASN   B CG   1 
ATOM   3519 O  OD1  . ASN   B 2 169 ? -11.58016 -49.52000 -25.83195 1.000 32.44302 ? 1221 ASN   B OD1  1 
ATOM   3520 N  ND2  . ASN   B 2 169 ? -12.57927 -48.02987 -27.17773 1.000 28.36040 ? 1221 ASN   B ND2  1 
ATOM   3521 N  N    . ASN   B 2 170 ? -13.07278 -46.12692 -21.93039 1.000 27.86882 ? 1222 ASN   B N    1 
ATOM   3522 C  CA   . ASN   B 2 170 ? -12.74295 -45.27110 -20.78721 1.000 27.32835 ? 1222 ASN   B CA   1 
ATOM   3523 C  C    . ASN   B 2 170 ? -11.58005 -44.33390 -21.09997 1.000 27.68670 ? 1222 ASN   B C    1 
ATOM   3524 O  O    . ASN   B 2 170 ? -10.72312 -44.09395 -20.25288 1.000 27.01200 ? 1222 ASN   B O    1 
ATOM   3525 C  CB   . ASN   B 2 170 ? -12.41692 -46.10129 -19.53435 1.000 29.47032 ? 1222 ASN   B CB   1 
ATOM   3526 C  CG   . ASN   B 2 170 ? -13.35978 -47.29144 -19.34063 1.000 32.66339 ? 1222 ASN   B CG   1 
ATOM   3527 O  OD1  . ASN   B 2 170 ? -12.91665 -48.43342 -19.20782 1.000 39.63674 ? 1222 ASN   B OD1  1 
ATOM   3528 N  ND2  . ASN   B 2 170 ? -14.65882 -47.02261 -19.31365 1.000 33.47933 ? 1222 ASN   B ND2  1 
ATOM   3529 N  N    . TYR   B 2 171 ? -11.53505 -43.79466 -22.31987 1.000 25.76498 ? 1223 TYR   B N    1 
ATOM   3530 C  CA   . TYR   B 2 171 ? -10.47015 -42.84447 -22.64163 1.000 25.04362 ? 1223 TYR   B CA   1 
ATOM   3531 C  C    . TYR   B 2 171 ? -10.53934 -41.63965 -21.70641 1.000 23.42291 ? 1223 TYR   B C    1 
ATOM   3532 O  O    . TYR   B 2 171 ? -11.60742 -41.06782 -21.49436 1.000 23.85134 ? 1223 TYR   B O    1 
ATOM   3533 C  CB   . TYR   B 2 171 ? -10.57412 -42.38021 -24.09555 1.000 24.07049 ? 1223 TYR   B CB   1 
ATOM   3534 C  CG   . TYR   B 2 171 ? -10.11294 -43.40596 -25.10972 1.000 23.35657 ? 1223 TYR   B CG   1 
ATOM   3535 C  CD1  . TYR   B 2 171 ? -8.78589  -43.81679 -25.15872 1.000 23.98579 ? 1223 TYR   B CD1  1 
ATOM   3536 C  CD2  . TYR   B 2 171 ? -10.99783 -43.92589 -26.04386 1.000 23.39500 ? 1223 TYR   B CD2  1 
ATOM   3537 C  CE1  . TYR   B 2 171 ? -8.35172  -44.75656 -26.11088 1.000 23.55051 ? 1223 TYR   B CE1  1 
ATOM   3538 C  CE2  . TYR   B 2 171 ? -10.57966 -44.86666 -26.99702 1.000 24.31580 ? 1223 TYR   B CE2  1 
ATOM   3539 C  CZ   . TYR   B 2 171 ? -9.26161  -45.27149 -27.02102 1.000 25.94854 ? 1223 TYR   B CZ   1 
ATOM   3540 O  OH   . TYR   B 2 171 ? -8.85645  -46.18727 -27.96118 1.000 28.66098 ? 1223 TYR   B OH   1 
ATOM   3541 N  N    . LYS   B 2 172 ? -9.39042  -41.24462 -21.15927 1.000 23.70673 ? 1224 LYS   B N    1 
ATOM   3542 C  CA   . LYS   B 2 172 ? -9.40960  -40.19481 -20.14207 1.000 28.71355 ? 1224 LYS   B CA   1 
ATOM   3543 C  C    . LYS   B 2 172 ? -9.75574  -38.82974 -20.72183 1.000 28.36505 ? 1224 LYS   B C    1 
ATOM   3544 O  O    . LYS   B 2 172 ? -10.31988 -37.99695 -20.00771 1.000 25.15492 ? 1224 LYS   B O    1 
ATOM   3545 C  CB   . LYS   B 2 172 ? -8.07265  -40.13479 -19.40699 1.000 24.81152 ? 1224 LYS   B CB   1 
ATOM   3546 C  CG   . LYS   B 2 172 ? -7.84355  -41.37892 -18.57521 1.000 31.27252 ? 1224 LYS   B CG   1 
ATOM   3547 C  CD   . LYS   B 2 172 ? -6.60760  -41.29193 -17.68813 1.000 36.15861 ? 1224 LYS   B CD   1 
ATOM   3548 C  CE   . LYS   B 2 172 ? -6.49250  -42.56108 -16.83336 1.000 53.18486 ? 1224 LYS   B CE   1 
ATOM   3549 N  NZ   . LYS   B 2 172 ? -5.19852  -42.66506 -16.10331 1.000 61.62407 ? 1224 LYS   B NZ   1 
ATOM   3550 N  N    . ARG   B 2 173 ? -9.44270  -38.57047 -21.99577 1.000 21.71329 ? 1225 ARG   B N    1 
ATOM   3551 C  CA   . ARG   B 2 173 ? -9.83782  -37.32339 -22.65055 1.000 22.09695 ? 1225 ARG   B CA   1 
ATOM   3552 C  C    . ARG   B 2 173 ? -10.83572 -37.59930 -23.76966 1.000 26.80889 ? 1225 ARG   B C    1 
ATOM   3553 O  O    . ARG   B 2 173 ? -10.76274 -36.99709 -24.84054 1.000 20.00191 ? 1225 ARG   B O    1 
ATOM   3554 C  CB   . ARG   B 2 173 ? -8.63288  -36.56714 -23.21335 1.000 24.58435 ? 1225 ARG   B CB   1 
ATOM   3555 C  CG   . ARG   B 2 173 ? -7.41994  -36.46716 -22.30326 1.000 30.57838 ? 1225 ARG   B CG   1 
ATOM   3556 C  CD   . ARG   B 2 173 ? -7.55813  -35.41138 -21.22807 1.000 38.55802 ? 1225 ARG   B CD   1 
ATOM   3557 N  NE   . ARG   B 2 173 ? -7.77427  -34.04532 -21.71182 1.000 45.50876 ? 1225 ARG   B NE   1 
ATOM   3558 C  CZ   . ARG   B 2 173 ? -6.83138  -33.11318 -21.82660 1.000 47.27514 ? 1225 ARG   B CZ   1 
ATOM   3559 N  NH1  . ARG   B 2 173 ? -5.54635  -33.39805 -21.66558 1.000 40.55446 ? 1225 ARG   B NH1  1 
ATOM   3560 N  NH2  . ARG   B 2 173 ? -7.18851  -31.85817 -22.09738 1.000 40.76424 ? 1225 ARG   B NH2  1 
ATOM   3561 N  N    . ASN   B 2 174 ? -11.75162 -38.54146 -23.53689 1.000 21.38557 ? 1226 ASN   B N    1 
ATOM   3562 C  CA   . ASN   B 2 174 ? -12.77253 -38.85839 -24.52000 1.000 21.66807 ? 1226 ASN   B CA   1 
ATOM   3563 C  C    . ASN   B 2 174 ? -13.47066 -37.59139 -24.99180 1.000 23.24700 ? 1226 ASN   B C    1 
ATOM   3564 O  O    . ASN   B 2 174 ? -13.79581 -36.71658 -24.18865 1.000 24.16349 ? 1226 ASN   B O    1 
ATOM   3565 C  CB   . ASN   B 2 174 ? -13.79544 -39.82063 -23.91124 1.000 20.78430 ? 1226 ASN   B CB   1 
ATOM   3566 C  CG   . ASN   B 2 174 ? -14.90235 -40.15559 -24.86936 1.000 25.05314 ? 1226 ASN   B CG   1 
ATOM   3567 O  OD1  . ASN   B 2 174 ? -14.64626 -40.39333 -26.04640 1.000 23.72476 ? 1226 ASN   B OD1  1 
ATOM   3568 N  ND2  . ASN   B 2 174 ? -16.15338 -40.16683 -24.37843 1.000 22.22171 ? 1226 ASN   B ND2  1 
ATOM   3569 N  N    . CYS   B 2 175 ? -13.67060 -37.48617 -26.30679 1.000 22.01469 ? 1227 CYS   B N    1 
ATOM   3570 C  CA   . CYS   B 2 175 ? -14.48669 -36.43615 -26.91364 1.000 22.32727 ? 1227 CYS   B CA   1 
ATOM   3571 C  C    . CYS   B 2 175 ? -15.37956 -37.07906 -27.96181 1.000 26.06965 ? 1227 CYS   B C    1 
ATOM   3572 O  O    . CYS   B 2 175 ? -14.87844 -37.60481 -28.96088 1.000 23.81352 ? 1227 CYS   B O    1 
ATOM   3573 C  CB   . CYS   B 2 175 ? -13.63079 -35.33592 -27.56938 1.000 22.26546 ? 1227 CYS   B CB   1 
ATOM   3574 S  SG   . CYS   B 2 175 ? -12.80699 -34.26004 -26.40014 1.000 29.32946 ? 1227 CYS   B SG   1 
ATOM   3575 N  N    . ALA   B 2 176 ? -16.68858 -37.02326 -27.74687 1.000 22.41230 ? 1228 ALA   B N    1 
ATOM   3576 C  CA   . ALA   B 2 176 ? -17.64646 -37.52320 -28.71402 1.000 19.27605 ? 1228 ALA   B CA   1 
ATOM   3577 C  C    . ALA   B 2 176 ? -17.78052 -36.54699 -29.87784 1.000 22.70913 ? 1228 ALA   B C    1 
ATOM   3578 O  O    . ALA   B 2 176 ? -17.70868 -35.33002 -29.70161 1.000 22.17168 ? 1228 ALA   B O    1 
ATOM   3579 C  CB   . ALA   B 2 176 ? -19.00847 -37.74449 -28.04613 1.000 20.47398 ? 1228 ALA   B CB   1 
ATOM   3580 N  N    . THR   B 2 177 ? -17.99239 -37.08879 -31.08295 1.000 21.00800 ? 1229 THR   B N    1 
ATOM   3581 C  CA   . THR   B 2 177 ? -17.93242 -36.26556 -32.28879 1.000 21.39440 ? 1229 THR   B CA   1 
ATOM   3582 C  C    . THR   B 2 177 ? -18.77728 -36.90645 -33.39096 1.000 23.41077 ? 1229 THR   B C    1 
ATOM   3583 O  O    . THR   B 2 177 ? -18.85213 -38.13544 -33.47820 1.000 23.48022 ? 1229 THR   B O    1 
ATOM   3584 C  CB   . THR   B 2 177 ? -16.47242 -36.09529 -32.74568 1.000 21.12245 ? 1229 THR   B CB   1 
ATOM   3585 O  OG1  . THR   B 2 177 ? -16.41046 -35.21707 -33.87851 1.000 23.11423 ? 1229 THR   B OG1  1 
ATOM   3586 C  CG2  . THR   B 2 177 ? -15.88323 -37.44415 -33.12991 1.000 23.47709 ? 1229 THR   B CG2  1 
ATOM   3587 N  N    . PHE   B 2 178 ? -19.43834 -36.07538 -34.19884 1.000 21.70027 ? 1230 PHE   B N    1 
ATOM   3588 C  CA   . PHE   B 2 178 ? -20.17622 -36.53425 -35.37597 1.000 25.39690 ? 1230 PHE   B CA   1 
ATOM   3589 C  C    . PHE   B 2 178 ? -19.22913 -36.73491 -36.55695 1.000 26.57214 ? 1230 PHE   B C    1 
ATOM   3590 O  O    . PHE   B 2 178 ? -18.20421 -36.06676 -36.65977 1.000 22.84157 ? 1230 PHE   B O    1 
ATOM   3591 C  CB   . PHE   B 2 178 ? -21.21633 -35.49929 -35.80983 1.000 22.80377 ? 1230 PHE   B CB   1 
ATOM   3592 C  CG   . PHE   B 2 178 ? -22.50336 -35.52859 -35.04390 1.000 27.20746 ? 1230 PHE   B CG   1 
ATOM   3593 C  CD1  . PHE   B 2 178 ? -23.45823 -36.50466 -35.30214 1.000 23.04226 ? 1230 PHE   B CD1  1 
ATOM   3594 C  CD2  . PHE   B 2 178 ? -22.79954 -34.52780 -34.12373 1.000 25.80665 ? 1230 PHE   B CD2  1 
ATOM   3595 C  CE1  . PHE   B 2 178 ? -24.66527 -36.50994 -34.62421 1.000 28.18842 ? 1230 PHE   B CE1  1 
ATOM   3596 C  CE2  . PHE   B 2 178 ? -24.01257 -34.52908 -33.43780 1.000 28.28450 ? 1230 PHE   B CE2  1 
ATOM   3597 C  CZ   . PHE   B 2 178 ? -24.94644 -35.51814 -33.69603 1.000 27.50254 ? 1230 PHE   B CZ   1 
ATOM   3598 N  N    . ASN   B 2 179 ? -19.60998 -37.62078 -37.48914 1.000 24.58063 ? 1231 ASN   B N    1 
ATOM   3599 C  CA   . ASN   B 2 179 ? -18.91289 -37.70645 -38.77212 1.000 26.76986 ? 1231 ASN   B CA   1 
ATOM   3600 C  C    . ASN   B 2 179 ? -19.43598 -36.61534 -39.69894 1.000 27.04493 ? 1231 ASN   B C    1 
ATOM   3601 O  O    . ASN   B 2 179 ? -20.41008 -35.93352 -39.38387 1.000 24.67146 ? 1231 ASN   B O    1 
ATOM   3602 C  CB   . ASN   B 2 179 ? -19.09469 -39.09936 -39.38439 1.000 28.44220 ? 1231 ASN   B CB   1 
ATOM   3603 C  CG   . ASN   B 2 179 ? -20.49863 -39.31842 -39.96351 1.000 30.69887 ? 1231 ASN   B CG   1 
ATOM   3604 O  OD1  . ASN   B 2 179 ? -21.48173 -38.76563 -39.47746 1.000 28.80857 ? 1231 ASN   B OD1  1 
ATOM   3605 N  ND2  . ASN   B 2 179 ? -20.58748 -40.13523 -41.01267 1.000 29.28297 ? 1231 ASN   B ND2  1 
ATOM   3606 N  N    . PRO   B 2 180 ? -18.80594 -36.41404 -40.86187 1.000 27.74527 ? 1232 PRO   B N    1 
ATOM   3607 C  CA   . PRO   B 2 180 ? -19.18503 -35.25593 -41.69467 1.000 28.56212 ? 1232 PRO   B CA   1 
ATOM   3608 C  C    . PRO   B 2 180 ? -20.64902 -35.22203 -42.11174 1.000 30.75798 ? 1232 PRO   B C    1 
ATOM   3609 O  O    . PRO   B 2 180 ? -21.19914 -34.12806 -42.29457 1.000 30.26016 ? 1232 PRO   B O    1 
ATOM   3610 C  CB   . PRO   B 2 180 ? -18.24795 -35.37859 -42.90264 1.000 28.52256 ? 1232 PRO   B CB   1 
ATOM   3611 C  CG   . PRO   B 2 180 ? -17.03890 -36.04855 -42.34770 1.000 28.68654 ? 1232 PRO   B CG   1 
ATOM   3612 C  CD   . PRO   B 2 180 ? -17.56184 -37.04480 -41.33992 1.000 29.86348 ? 1232 PRO   B CD   1 
ATOM   3613 N  N    . THR   B 2 181 ? -21.31087 -36.36508 -42.26600 1.000 22.94158 ? 1233 THR   B N    1 
ATOM   3614 C  CA   . THR   B 2 181 ? -22.71285 -36.36418 -42.66407 1.000 28.22270 ? 1233 THR   B CA   1 
ATOM   3615 C  C    . THR   B 2 181 ? -23.66489 -36.56952 -41.48516 1.000 33.13345 ? 1233 THR   B C    1 
ATOM   3616 O  O    . THR   B 2 181 ? -24.87486 -36.71863 -41.69226 1.000 32.43262 ? 1233 THR   B O    1 
ATOM   3617 C  CB   . THR   B 2 181 ? -22.95766 -37.41500 -43.75628 1.000 36.77238 ? 1233 THR   B CB   1 
ATOM   3618 O  OG1  . THR   B 2 181 ? -22.25953 -38.62998 -43.43848 1.000 35.77100 ? 1233 THR   B OG1  1 
ATOM   3619 C  CG2  . THR   B 2 181 ? -22.46065 -36.89469 -45.09616 1.000 33.91094 ? 1233 THR   B CG2  1 
ATOM   3620 N  N    . ASP   B 2 182 ? -23.15496 -36.54369 -40.25713 1.000 30.86481 ? 1234 ASP   B N    1 
ATOM   3621 C  CA   . ASP   B 2 182 ? -23.95002 -36.54602 -39.02717 1.000 32.49265 ? 1234 ASP   B CA   1 
ATOM   3622 C  C    . ASP   B 2 182 ? -24.70488 -37.84515 -38.78746 1.000 30.03329 ? 1234 ASP   B C    1 
ATOM   3623 O  O    . ASP   B 2 182 ? -25.50192 -37.91343 -37.84252 1.000 34.81920 ? 1234 ASP   B O    1 
ATOM   3624 C  CB   . ASP   B 2 182 ? -24.95317 -35.38914 -38.99701 1.000 32.23338 ? 1234 ASP   B CB   1 
ATOM   3625 C  CG   . ASP   B 2 182 ? -24.28432 -34.03504 -39.13272 1.000 35.91155 ? 1234 ASP   B CG   1 
ATOM   3626 O  OD1  . ASP   B 2 182 ? -23.18037 -33.86101 -38.57363 1.000 39.97263 ? 1234 ASP   B OD1  1 
ATOM   3627 O  OD2  . ASP   B 2 182 ? -24.85739 -33.15098 -39.80158 1.000 39.20507 ? 1234 ASP   B OD2  1 
ATOM   3628 N  N    . ASP   B 2 183 ? -24.48271 -38.87697 -39.60564 1.000 33.29389 ? 1235 ASP   B N    1 
ATOM   3629 C  CA   . ASP   B 2 183 ? -25.15856 -40.15908 -39.44792 1.000 31.37480 ? 1235 ASP   B CA   1 
ATOM   3630 C  C    . ASP   B 2 183 ? -24.42349 -41.11017 -38.51706 1.000 27.42723 ? 1235 ASP   B C    1 
ATOM   3631 O  O    . ASP   B 2 183 ? -25.00939 -42.11732 -38.10528 1.000 32.71731 ? 1235 ASP   B O    1 
ATOM   3632 C  CB   . ASP   B 2 183 ? -25.33840 -40.84185 -40.81606 1.000 35.78893 ? 1235 ASP   B CB   1 
ATOM   3633 C  CG   . ASP   B 2 183 ? -24.01334 -41.00954 -41.56902 1.000 37.51484 ? 1235 ASP   B CG   1 
ATOM   3634 O  OD1  . ASP   B 2 183 ? -23.33945 -39.99141 -41.83679 1.000 38.31586 ? 1235 ASP   B OD1  1 
ATOM   3635 O  OD2  . ASP   B 2 183 ? -23.64118 -42.16244 -41.88822 1.000 41.49265 ? 1235 ASP   B OD2  1 
ATOM   3636 N  N    . LEU   B 2 184 ? -23.16255 -40.83108 -38.19894 1.000 23.86831 ? 1236 LEU   B N    1 
ATOM   3637 C  CA   . LEU   B 2 184 ? -22.36449 -41.65015 -37.30005 1.000 25.74800 ? 1236 LEU   B CA   1 
ATOM   3638 C  C    . LEU   B 2 184 ? -21.79966 -40.79429 -36.17586 1.000 24.50814 ? 1236 LEU   B C    1 
ATOM   3639 O  O    . LEU   B 2 184 ? -21.60680 -39.58724 -36.32762 1.000 25.78520 ? 1236 LEU   B O    1 
ATOM   3640 C  CB   . LEU   B 2 184 ? -21.19537 -42.32287 -38.02612 1.000 22.57160 ? 1236 LEU   B CB   1 
ATOM   3641 C  CG   . LEU   B 2 184 ? -21.56920 -43.17168 -39.24730 1.000 28.63087 ? 1236 LEU   B CG   1 
ATOM   3642 C  CD1  . LEU   B 2 184 ? -20.31509 -43.80642 -39.83335 1.000 31.14602 ? 1236 LEU   B CD1  1 
ATOM   3643 C  CD2  . LEU   B 2 184 ? -22.56109 -44.23688 -38.85455 1.000 29.78225 ? 1236 LEU   B CD2  1 
ATOM   3644 N  N    . VAL   B 2 185 ? -21.52364 -41.43747 -35.04797 1.000 23.15842 ? 1237 VAL   B N    1 
ATOM   3645 C  CA   . VAL   B 2 185 ? -20.83978 -40.79260 -33.93781 1.000 25.05354 ? 1237 VAL   B CA   1 
ATOM   3646 C  C    . VAL   B 2 185 ? -19.67070 -41.66453 -33.52791 1.000 24.91607 ? 1237 VAL   B C    1 
ATOM   3647 O  O    . VAL   B 2 185 ? -19.78555 -42.89355 -33.49215 1.000 24.93538 ? 1237 VAL   B O    1 
ATOM   3648 C  CB   . VAL   B 2 185 ? -21.77888 -40.55994 -32.73581 1.000 26.30097 ? 1237 VAL   B CB   1 
ATOM   3649 C  CG1  . VAL   B 2 185 ? -20.97495 -40.50209 -31.41976 1.000 20.11412 ? 1237 VAL   B CG1  1 
ATOM   3650 C  CG2  . VAL   B 2 185 ? -22.57002 -39.28600 -32.94762 1.000 22.55732 ? 1237 VAL   B CG2  1 
ATOM   3651 N  N    . LEU   B 2 186 ? -18.54479 -41.03045 -33.23373 1.000 21.86431 ? 1238 LEU   B N    1 
ATOM   3652 C  CA   . LEU   B 2 186 ? -17.43575 -41.68144 -32.56179 1.000 22.53039 ? 1238 LEU   B CA   1 
ATOM   3653 C  C    . LEU   B 2 186 ? -17.45788 -41.21572 -31.10970 1.000 24.84699 ? 1238 LEU   B C    1 
ATOM   3654 O  O    . LEU   B 2 186 ? -17.40305 -40.00876 -30.84647 1.000 21.85071 ? 1238 LEU   B O    1 
ATOM   3655 C  CB   . LEU   B 2 186 ? -16.11075 -41.32715 -33.23665 1.000 21.66626 ? 1238 LEU   B CB   1 
ATOM   3656 C  CG   . LEU   B 2 186 ? -14.94665 -42.28505 -33.06477 1.000 30.49195 ? 1238 LEU   B CG   1 
ATOM   3657 C  CD1  . LEU   B 2 186 ? -15.37645 -43.70103 -33.42606 1.000 32.67677 ? 1238 LEU   B CD1  1 
ATOM   3658 C  CD2  . LEU   B 2 186 ? -13.77566 -41.81074 -33.94462 1.000 26.88391 ? 1238 LEU   B CD2  1 
ATOM   3659 N  N    . ASN   B 2 187 ? -17.59482 -42.15991 -30.18089 1.000 24.27745 ? 1239 ASN   B N    1 
ATOM   3660 C  CA   . ASN   B 2 187 ? -17.57593 -41.86018 -28.75083 1.000 23.02789 ? 1239 ASN   B CA   1 
ATOM   3661 C  C    . ASN   B 2 187 ? -16.76184 -42.91822 -28.02599 1.000 21.69821 ? 1239 ASN   B C    1 
ATOM   3662 O  O    . ASN   B 2 187 ? -17.10570 -44.10425 -28.06523 1.000 24.70388 ? 1239 ASN   B O    1 
ATOM   3663 C  CB   . ASN   B 2 187 ? -18.98697 -41.80247 -28.14590 1.000 23.06914 ? 1239 ASN   B CB   1 
ATOM   3664 C  CG   . ASN   B 2 187 ? -18.94609 -41.47774 -26.65683 1.000 24.65564 ? 1239 ASN   B CG   1 
ATOM   3665 O  OD1  . ASN   B 2 187 ? -18.33424 -40.48674 -26.26661 1.000 22.74005 ? 1239 ASN   B OD1  1 
ATOM   3666 N  ND2  . ASN   B 2 187 ? -19.53003 -42.33597 -25.82403 1.000 21.33328 ? 1239 ASN   B ND2  1 
ATOM   3667 N  N    . ASP   B 2 188 ? -15.68293 -42.49221 -27.37385 1.000 19.45293 ? 1240 ASP   B N    1 
ATOM   3668 C  CA   . ASP   B 2 188 ? -14.86787 -43.37827 -26.55597 1.000 23.79231 ? 1240 ASP   B CA   1 
ATOM   3669 C  C    . ASP   B 2 188 ? -14.31468 -44.55004 -27.37016 1.000 25.68503 ? 1240 ASP   B C    1 
ATOM   3670 O  O    . ASP   B 2 188 ? -14.19057 -45.67312 -26.87937 1.000 26.55473 ? 1240 ASP   B O    1 
ATOM   3671 C  CB   . ASP   B 2 188 ? -15.67587 -43.88359 -25.36011 1.000 25.26655 ? 1240 ASP   B CB   1 
ATOM   3672 C  CG   . ASP   B 2 188 ? -14.79488 -44.34970 -24.22315 1.000 25.44600 ? 1240 ASP   B CG   1 
ATOM   3673 O  OD1  . ASP   B 2 188 ? -13.65094 -43.83958 -24.10499 1.000 25.20735 ? 1240 ASP   B OD1  1 
ATOM   3674 O  OD2  . ASP   B 2 188 ? -15.24881 -45.23390 -23.46034 1.000 26.88070 ? 1240 ASP   B OD2  1 
ATOM   3675 N  N    . GLY   B 2 189 ? -13.96864 -44.29076 -28.62709 1.000 27.41189 ? 1241 GLY   B N    1 
ATOM   3676 C  CA   . GLY   B 2 189 ? -13.47447 -45.34854 -29.48927 1.000 29.32755 ? 1241 GLY   B CA   1 
ATOM   3677 C  C    . GLY   B 2 189 ? -14.52732 -46.31558 -29.98851 1.000 26.22934 ? 1241 GLY   B C    1 
ATOM   3678 O  O    . GLY   B 2 189 ? -14.17217 -47.37743 -30.51169 1.000 27.63380 ? 1241 GLY   B O    1 
ATOM   3679 N  N    . VAL   B 2 190 ? -15.80737 -45.98876 -29.84052 1.000 21.77134 ? 1242 VAL   B N    1 
ATOM   3680 C  CA   . VAL   B 2 190 ? -16.90024 -46.82580 -30.30873 1.000 25.29263 ? 1242 VAL   B CA   1 
ATOM   3681 C  C    . VAL   B 2 190 ? -17.63828 -46.06269 -31.39963 1.000 27.47708 ? 1242 VAL   B C    1 
ATOM   3682 O  O    . VAL   B 2 190 ? -17.96143 -44.87976 -31.23242 1.000 25.99561 ? 1242 VAL   B O    1 
ATOM   3683 C  CB   . VAL   B 2 190 ? -17.84826 -47.21814 -29.15586 1.000 27.30789 ? 1242 VAL   B CB   1 
ATOM   3684 C  CG1  . VAL   B 2 190 ? -18.96212 -48.12818 -29.65009 1.000 27.52555 ? 1242 VAL   B CG1  1 
ATOM   3685 C  CG2  . VAL   B 2 190 ? -17.07024 -47.88925 -28.03394 1.000 27.67066 ? 1242 VAL   B CG2  1 
ATOM   3686 N  N    . LEU   B 2 191 ? -17.89113 -46.73251 -32.52177 1.000 22.38093 ? 1243 LEU   B N    1 
ATOM   3687 C  CA   . LEU   B 2 191 ? -18.61115 -46.12839 -33.63069 1.000 23.76849 ? 1243 LEU   B CA   1 
ATOM   3688 C  C    . LEU   B 2 191 ? -20.09612 -46.42359 -33.48183 1.000 28.18531 ? 1243 LEU   B C    1 
ATOM   3689 O  O    . LEU   B 2 191 ? -20.48999 -47.58367 -33.33107 1.000 27.52771 ? 1243 LEU   B O    1 
ATOM   3690 C  CB   . LEU   B 2 191 ? -18.08001 -46.67007 -34.95977 1.000 23.83755 ? 1243 LEU   B CB   1 
ATOM   3691 C  CG   . LEU   B 2 191 ? -18.63901 -46.08089 -36.25169 1.000 28.99208 ? 1243 LEU   B CG   1 
ATOM   3692 C  CD1  . LEU   B 2 191 ? -18.32519 -44.58383 -36.38639 1.000 25.91741 ? 1243 LEU   B CD1  1 
ATOM   3693 C  CD2  . LEU   B 2 191 ? -18.07185 -46.86760 -37.45280 1.000 29.08194 ? 1243 LEU   B CD2  1 
ATOM   3694 N  N    . TRP   B 2 192 ? -20.91425 -45.37469 -33.50368 1.000 22.69816 ? 1244 TRP   B N    1 
ATOM   3695 C  CA   . TRP   B 2 192 ? -22.34824 -45.50390 -33.30778 1.000 26.35847 ? 1244 TRP   B CA   1 
ATOM   3696 C  C    . TRP   B 2 192 ? -23.10122 -45.10076 -34.56474 1.000 31.24208 ? 1244 TRP   B C    1 
ATOM   3697 O  O    . TRP   B 2 192 ? -22.78931 -44.08560 -35.19654 1.000 27.59041 ? 1244 TRP   B O    1 
ATOM   3698 C  CB   . TRP   B 2 192 ? -22.84741 -44.64718 -32.14264 1.000 25.33858 ? 1244 TRP   B CB   1 
ATOM   3699 C  CG   . TRP   B 2 192 ? -22.35543 -45.09138 -30.78470 1.000 26.66013 ? 1244 TRP   B CG   1 
ATOM   3700 C  CD1  . TRP   B 2 192 ? -21.14049 -44.82534 -30.22859 1.000 26.64469 ? 1244 TRP   B CD1  1 
ATOM   3701 C  CD2  . TRP   B 2 192 ? -23.08239 -45.86065 -29.81289 1.000 27.34945 ? 1244 TRP   B CD2  1 
ATOM   3702 N  NE1  . TRP   B 2 192 ? -21.05649 -45.38856 -28.97069 1.000 24.76467 ? 1244 TRP   B NE1  1 
ATOM   3703 C  CE2  . TRP   B 2 192 ? -22.23743 -46.02476 -28.69387 1.000 28.12446 ? 1244 TRP   B CE2  1 
ATOM   3704 C  CE3  . TRP   B 2 192 ? -24.36132 -46.42281 -29.77906 1.000 30.81139 ? 1244 TRP   B CE3  1 
ATOM   3705 C  CZ2  . TRP   B 2 192 ? -22.62540 -46.74302 -27.56103 1.000 28.92254 ? 1244 TRP   B CZ2  1 
ATOM   3706 C  CZ3  . TRP   B 2 192 ? -24.74930 -47.12608 -28.64522 1.000 30.82865 ? 1244 TRP   B CZ3  1 
ATOM   3707 C  CH2  . TRP   B 2 192 ? -23.88234 -47.28218 -27.55620 1.000 32.09130 ? 1244 TRP   B CH2  1 
ATOM   3708 N  N    . ASP   B 2 193 ? -24.11711 -45.88982 -34.90195 1.000 29.61239 ? 1245 ASP   B N    1 
ATOM   3709 C  CA   . ASP   B 2 193 ? -25.10510 -45.48275 -35.88893 1.000 29.16281 ? 1245 ASP   B CA   1 
ATOM   3710 C  C    . ASP   B 2 193 ? -26.14925 -44.61401 -35.20182 1.000 28.85313 ? 1245 ASP   B C    1 
ATOM   3711 O  O    . ASP   B 2 193 ? -26.83824 -45.07326 -34.28294 1.000 31.18892 ? 1245 ASP   B O    1 
ATOM   3712 C  CB   . ASP   B 2 193 ? -25.76592 -46.69971 -36.53419 1.000 27.78136 ? 1245 ASP   B CB   1 
ATOM   3713 C  CG   . ASP   B 2 193 ? -26.83691 -46.30565 -37.52218 1.000 29.11823 ? 1245 ASP   B CG   1 
ATOM   3714 O  OD1  . ASP   B 2 193 ? -26.46591 -45.86640 -38.62507 1.000 41.23957 ? 1245 ASP   B OD1  1 
ATOM   3715 O  OD2  . ASP   B 2 193 ? -28.04392 -46.38186 -37.18425 1.000 39.46662 ? 1245 ASP   B OD2  1 
ATOM   3716 N  N    . VAL   B 2 194 ? -26.26938 -43.36094 -35.64059 1.000 27.94654 ? 1246 VAL   B N    1 
ATOM   3717 C  CA   . VAL   B 2 194 ? -27.10453 -42.40218 -34.91945 1.000 28.65633 ? 1246 VAL   B CA   1 
ATOM   3718 C  C    . VAL   B 2 194 ? -28.58748 -42.73833 -35.07860 1.000 35.43556 ? 1246 VAL   B C    1 
ATOM   3719 O  O    . VAL   B 2 194 ? -29.34353 -42.76560 -34.09864 1.000 29.66117 ? 1246 VAL   B O    1 
ATOM   3720 C  CB   . VAL   B 2 194 ? -26.79768 -40.97305 -35.39017 1.000 31.04212 ? 1246 VAL   B CB   1 
ATOM   3721 C  CG1  . VAL   B 2 194 ? -27.83683 -40.00828 -34.83704 1.000 33.23587 ? 1246 VAL   B CG1  1 
ATOM   3722 C  CG2  . VAL   B 2 194 ? -25.38075 -40.56496 -34.97001 1.000 25.88812 ? 1246 VAL   B CG2  1 
ATOM   3723 N  N    . ARG   B 2 195 ? -29.02639 -42.98315 -36.31367 1.000 29.72031 ? 1247 ARG   B N    1 
ATOM   3724 C  CA   . ARG   B 2 195 ? -30.44934 -43.21327 -36.56079 1.000 33.79145 ? 1247 ARG   B CA   1 
ATOM   3725 C  C    . ARG   B 2 195 ? -30.98025 -44.36350 -35.71903 1.000 32.31036 ? 1247 ARG   B C    1 
ATOM   3726 O  O    . ARG   B 2 195 ? -32.09529 -44.29173 -35.19508 1.000 32.59356 ? 1247 ARG   B O    1 
ATOM   3727 C  CB   . ARG   B 2 195 ? -30.69323 -43.47902 -38.04985 1.000 33.62680 ? 1247 ARG   B CB   1 
ATOM   3728 C  CG   . ARG   B 2 195 ? -32.14317 -43.83714 -38.38200 1.000 45.76282 ? 1247 ARG   B CG   1 
ATOM   3729 C  CD   . ARG   B 2 195 ? -32.52413 -43.54291 -39.83696 1.000 49.89429 ? 1247 ARG   B CD   1 
ATOM   3730 N  NE   . ARG   B 2 195 ? -33.95209 -43.76104 -40.05708 1.000 53.20966 ? 1247 ARG   B NE   1 
ATOM   3731 C  CZ   . ARG   B 2 195 ? -34.57104 -43.61090 -41.22309 1.000 61.03431 ? 1247 ARG   B CZ   1 
ATOM   3732 N  NH1  . ARG   B 2 195 ? -33.91403 -43.23461 -42.31298 1.000 54.38923 ? 1247 ARG   B NH1  1 
ATOM   3733 N  NH2  . ARG   B 2 195 ? -35.88101 -43.85004 -41.30320 1.000 54.52576 ? 1247 ARG   B NH2  1 
ATOM   3734 N  N    . SER   B 2 196 ? -30.20613 -45.43543 -35.57519 1.000 31.06510 ? 1248 SER   B N    1 
ATOM   3735 C  CA   . SER   B 2 196 ? -30.64603 -46.57263 -34.78243 1.000 36.54590 ? 1248 SER   B CA   1 
ATOM   3736 C  C    . SER   B 2 196 ? -30.14211 -46.53084 -33.34840 1.000 36.42633 ? 1248 SER   B C    1 
ATOM   3737 O  O    . SER   B 2 196 ? -30.54805 -47.37705 -32.54558 1.000 33.60199 ? 1248 SER   B O    1 
ATOM   3738 C  CB   . SER   B 2 196 ? -30.19684 -47.88746 -35.43466 1.000 38.32382 ? 1248 SER   B CB   1 
ATOM   3739 O  OG   . SER   B 2 196 ? -28.81982 -48.12933 -35.22763 1.000 39.00083 ? 1248 SER   B OG   1 
ATOM   3740 N  N    . ALA   B 2 197 ? -29.26525 -45.58580 -33.00517 1.000 35.90830 ? 1249 ALA   B N    1 
ATOM   3741 C  CA   . ALA   B 2 197 ? -28.67333 -45.53398 -31.67113 1.000 32.40458 ? 1249 ALA   B CA   1 
ATOM   3742 C  C    . ALA   B 2 197 ? -28.01019 -46.85997 -31.30334 1.000 32.79516 ? 1249 ALA   B C    1 
ATOM   3743 O  O    . ALA   B 2 197 ? -28.07619 -47.31019 -30.16143 1.000 34.99414 ? 1249 ALA   B O    1 
ATOM   3744 C  CB   . ALA   B 2 197 ? -29.71843 -45.13831 -30.62211 1.000 37.22417 ? 1249 ALA   B CB   1 
ATOM   3745 N  N    . GLN   B 2 198 ? -27.34906 -47.48771 -32.27143 1.000 32.85259 ? 1250 GLN   B N    1 
ATOM   3746 C  CA   . GLN   B 2 198 ? -26.68391 -48.76667 -32.05263 1.000 38.54914 ? 1250 GLN   B CA   1 
ATOM   3747 C  C    . GLN   B 2 198 ? -25.17991 -48.65444 -32.27553 1.000 31.53058 ? 1250 GLN   B C    1 
ATOM   3748 O  O    . GLN   B 2 198 ? -24.72294 -48.02020 -33.23738 1.000 36.21127 ? 1250 GLN   B O    1 
ATOM   3749 C  CB   . GLN   B 2 198 ? -27.25273 -49.85756 -32.98287 1.000 36.18115 ? 1250 GLN   B CB   1 
ATOM   3750 C  CG   . GLN   B 2 198 ? -28.65769 -50.33480 -32.62804 1.000 43.42687 ? 1250 GLN   B CG   1 
ATOM   3751 C  CD   . GLN   B 2 198 ? -28.75870 -50.87608 -31.20014 1.000 50.30606 ? 1250 GLN   B CD   1 
ATOM   3752 O  OE1  . GLN   B 2 198 ? -29.75077 -50.64533 -30.50015 1.000 57.84697 ? 1250 GLN   B OE1  1 
ATOM   3753 N  NE2  . GLN   B 2 198 ? -27.73064 -51.60304 -30.76822 1.000 60.21463 ? 1250 GLN   B NE2  1 
ATOM   3754 N  N    . ALA   B 2 199 ? -24.40889 -49.27852 -31.38260 1.000 30.00928 ? 1251 ALA   B N    1 
ATOM   3755 C  CA   . ALA   B 2 199 ? -22.97286 -49.38330 -31.58555 1.000 30.94792 ? 1251 ALA   B CA   1 
ATOM   3756 C  C    . ALA   B 2 199 ? -22.71068 -50.36806 -32.71272 1.000 40.89622 ? 1251 ALA   B C    1 
ATOM   3757 O  O    . ALA   B 2 199 ? -23.19054 -51.50412 -32.67496 1.000 38.00207 ? 1251 ALA   B O    1 
ATOM   3758 C  CB   . ALA   B 2 199 ? -22.27188 -49.84246 -30.30960 1.000 27.72302 ? 1251 ALA   B CB   1 
ATOM   3759 N  N    . ILE   B 2 200 ? -21.96368 -49.93878 -33.72360 1.000 32.41954 ? 1252 ILE   B N    1 
ATOM   3760 C  CA   . ILE   B 2 200 ? -21.66151 -50.81453 -34.84575 1.000 36.34606 ? 1252 ILE   B CA   1 
ATOM   3761 C  C    . ILE   B 2 200 ? -20.23145 -51.32836 -34.83077 1.000 33.98315 ? 1252 ILE   B C    1 
ATOM   3762 O  O    . ILE   B 2 200 ? -19.93729 -52.30119 -35.54193 1.000 32.83632 ? 1252 ILE   B O    1 
ATOM   3763 C  CB   . ILE   B 2 200 ? -21.97852 -50.13531 -36.19363 1.000 35.08043 ? 1252 ILE   B CB   1 
ATOM   3764 C  CG1  . ILE   B 2 200 ? -21.28668 -48.78920 -36.32334 1.000 37.97816 ? 1252 ILE   B CG1  1 
ATOM   3765 C  CG2  . ILE   B 2 200 ? -23.46454 -49.94446 -36.34968 1.000 45.55057 ? 1252 ILE   B CG2  1 
ATOM   3766 C  CD1  . ILE   B 2 200 ? -21.43068 -48.18296 -37.71624 1.000 40.48648 ? 1252 ILE   B CD1  1 
ATOM   3767 N  N    . HIS   B 2 201 ? -19.33856 -50.74040 -34.03961 1.000 29.37501 ? 1253 HIS   B N    1 
ATOM   3768 C  CA   . HIS   B 2 201 ? -17.97250 -51.23924 -34.01063 1.000 25.54094 ? 1253 HIS   B CA   1 
ATOM   3769 C  C    . HIS   B 2 201 ? -17.22165 -50.58536 -32.85646 1.000 28.63720 ? 1253 HIS   B C    1 
ATOM   3770 O  O    . HIS   B 2 201 ? -17.32681 -49.37341 -32.65424 1.000 28.70485 ? 1253 HIS   B O    1 
ATOM   3771 C  CB   . HIS   B 2 201 ? -17.26347 -50.94990 -35.34553 1.000 29.40873 ? 1253 HIS   B CB   1 
ATOM   3772 C  CG   . HIS   B 2 201 ? -15.88239 -51.52471 -35.43757 1.000 35.42927 ? 1253 HIS   B CG   1 
ATOM   3773 N  ND1  . HIS   B 2 201 ? -15.64321 -52.82961 -35.81180 1.000 41.14820 ? 1253 HIS   B ND1  1 
ATOM   3774 C  CD2  . HIS   B 2 201 ? -14.66847 -50.97561 -35.19840 1.000 31.59545 ? 1253 HIS   B CD2  1 
ATOM   3775 C  CE1  . HIS   B 2 201 ? -14.34319 -53.05845 -35.80377 1.000 37.94197 ? 1253 HIS   B CE1  1 
ATOM   3776 N  NE2  . HIS   B 2 201 ? -13.72834 -51.95045 -35.43353 1.000 33.17985 ? 1253 HIS   B NE2  1 
ATOM   3777 N  N    . LYS   B 2 202 ? -16.45859 -51.38141 -32.11757 1.000 24.57314 ? 1254 LYS   B N    1 
ATOM   3778 C  CA   . LYS   B 2 202 ? -15.54971 -50.86049 -31.10342 1.000 30.88720 ? 1254 LYS   B CA   1 
ATOM   3779 C  C    . LYS   B 2 202 ? -14.12167 -50.98922 -31.60237 1.000 30.68428 ? 1254 LYS   B C    1 
ATOM   3780 O  O    . LYS   B 2 202 ? -13.67851 -52.09010 -31.93855 1.000 31.83652 ? 1254 LYS   B O    1 
ATOM   3781 C  CB   . LYS   B 2 202 ? -15.69069 -51.60276 -29.77857 1.000 31.67411 ? 1254 LYS   B CB   1 
ATOM   3782 C  CG   . LYS   B 2 202 ? -14.57479 -51.26281 -28.78645 1.000 29.40943 ? 1254 LYS   B CG   1 
ATOM   3783 C  CD   . LYS   B 2 202 ? -14.67875 -52.08606 -27.51861 1.000 39.99832 ? 1254 LYS   B CD   1 
ATOM   3784 C  CE   . LYS   B 2 202 ? -13.39681 -51.97706 -26.70152 1.000 34.81825 ? 1254 LYS   B CE   1 
ATOM   3785 N  NZ   . LYS   B 2 202 ? -13.32774 -53.04724 -25.67471 1.000 52.55147 ? 1254 LYS   B NZ   1 
ATOM   3786 N  N    . PHE   B 2 203 ? -13.39880 -49.87713 -31.64212 1.000 27.21168 ? 1255 PHE   B N    1 
ATOM   3787 C  CA   . PHE   B 2 203 ? -11.98377 -49.93189 -31.97105 1.000 23.71941 ? 1255 PHE   B CA   1 
ATOM   3788 C  C    . PHE   B 2 203 ? -11.18181 -50.23303 -30.71707 1.000 29.94447 ? 1255 PHE   B C    1 
ATOM   3789 O  O    . PHE   B 2 203 ? -11.46493 -49.69127 -29.64398 1.000 28.41766 ? 1255 PHE   B O    1 
ATOM   3790 C  CB   . PHE   B 2 203 ? -11.52090 -48.62072 -32.60278 1.000 22.44869 ? 1255 PHE   B CB   1 
ATOM   3791 C  CG   . PHE   B 2 203 ? -12.17186 -48.33555 -33.91476 1.000 24.36721 ? 1255 PHE   B CG   1 
ATOM   3792 C  CD1  . PHE   B 2 203 ? -11.61874 -48.80526 -35.09482 1.000 28.89587 ? 1255 PHE   B CD1  1 
ATOM   3793 C  CD2  . PHE   B 2 203 ? -13.35695 -47.61468 -33.97069 1.000 24.69104 ? 1255 PHE   B CD2  1 
ATOM   3794 C  CE1  . PHE   B 2 203 ? -12.23571 -48.55210 -36.31981 1.000 26.70146 ? 1255 PHE   B CE1  1 
ATOM   3795 C  CE2  . PHE   B 2 203 ? -13.97291 -47.35253 -35.18567 1.000 29.42003 ? 1255 PHE   B CE2  1 
ATOM   3796 C  CZ   . PHE   B 2 203 ? -13.40979 -47.82723 -36.36473 1.000 29.01268 ? 1255 PHE   B CZ   1 
ATOM   3797 N  N    . ASP   B 2 204 ? -10.18469 -51.10788 -30.85618 1.000 26.78630 ? 1256 ASP   B N    1 
ATOM   3798 C  CA   . ASP   B 2 204 ? -9.35271  -51.49200 -29.72120 1.000 27.63785 ? 1256 ASP   B CA   1 
ATOM   3799 C  C    . ASP   B 2 204 ? -8.62089  -50.28702 -29.13694 1.000 28.56260 ? 1256 ASP   B C    1 
ATOM   3800 O  O    . ASP   B 2 204 ? -8.29596  -49.32285 -29.83474 1.000 26.77636 ? 1256 ASP   B O    1 
ATOM   3801 C  CB   . ASP   B 2 204 ? -8.32456  -52.54879 -30.13035 1.000 31.67484 ? 1256 ASP   B CB   1 
ATOM   3802 C  CG   . ASP   B 2 204 ? -8.96237  -53.87280 -30.52563 1.000 37.56109 ? 1256 ASP   B CG   1 
ATOM   3803 O  OD1  . ASP   B 2 204 ? -10.02336 -54.22103 -29.97876 1.000 36.43445 ? 1256 ASP   B OD1  1 
ATOM   3804 O  OD2  . ASP   B 2 204 ? -8.40324  -54.55456 -31.39973 1.000 37.14803 ? 1256 ASP   B OD2  1 
ATOM   3805 N  N    . LYS   B 2 205 ? -8.32594  -50.37723 -27.84094 1.000 27.58084 ? 1257 LYS   B N    1 
ATOM   3806 C  CA   . LYS   B 2 205 ? -7.71312  -49.28929 -27.08970 1.000 29.97208 ? 1257 LYS   B CA   1 
ATOM   3807 C  C    . LYS   B 2 205 ? -6.19710  -49.43410 -27.12064 1.000 26.96626 ? 1257 LYS   B C    1 
ATOM   3808 O  O    . LYS   B 2 205 ? -5.65801  -50.41513 -26.60580 1.000 28.52645 ? 1257 LYS   B O    1 
ATOM   3809 C  CB   . LYS   B 2 205 ? -8.22219  -49.30263 -25.65073 1.000 31.03413 ? 1257 LYS   B CB   1 
ATOM   3810 C  CG   . LYS   B 2 205 ? -7.58037  -48.27272 -24.73450 1.000 28.94943 ? 1257 LYS   B CG   1 
ATOM   3811 C  CD   . LYS   B 2 205 ? -8.25944  -48.30006 -23.36054 1.000 27.52491 ? 1257 LYS   B CD   1 
ATOM   3812 C  CE   . LYS   B 2 205 ? -7.67262  -47.25517 -22.42031 1.000 30.71931 ? 1257 LYS   B CE   1 
ATOM   3813 N  NZ   . LYS   B 2 205 ? -8.43269  -47.22451 -21.12235 1.000 25.99123 ? 1257 LYS   B NZ   1 
ATOM   3814 N  N    . PHE   B 2 206 ? -5.51019  -48.45091 -27.71142 1.000 25.66252 ? 1258 PHE   B N    1 
ATOM   3815 C  CA   . PHE   B 2 206 ? -4.05418  -48.46571 -27.78735 1.000 25.56342 ? 1258 PHE   B CA   1 
ATOM   3816 C  C    . PHE   B 2 206 ? -3.40736  -47.24876 -27.13408 1.000 26.11748 ? 1258 PHE   B C    1 
ATOM   3817 O  O    . PHE   B 2 206 ? -2.21638  -47.01257 -27.34497 1.000 26.64012 ? 1258 PHE   B O    1 
ATOM   3818 C  CB   . PHE   B 2 206 ? -3.59509  -48.57838 -29.24534 1.000 25.38827 ? 1258 PHE   B CB   1 
ATOM   3819 C  CG   . PHE   B 2 206 ? -3.96989  -49.88531 -29.88961 1.000 28.64742 ? 1258 PHE   B CG   1 
ATOM   3820 C  CD1  . PHE   B 2 206 ? -3.36577  -51.06731 -29.48080 1.000 30.54881 ? 1258 PHE   B CD1  1 
ATOM   3821 C  CD2  . PHE   B 2 206 ? -4.92183  -49.93523 -30.89867 1.000 27.07044 ? 1258 PHE   B CD2  1 
ATOM   3822 C  CE1  . PHE   B 2 206 ? -3.71559  -52.28125 -30.04805 1.000 28.22702 ? 1258 PHE   B CE1  1 
ATOM   3823 C  CE2  . PHE   B 2 206 ? -5.26665  -51.14516 -31.49492 1.000 25.74444 ? 1258 PHE   B CE2  1 
ATOM   3824 C  CZ   . PHE   B 2 206 ? -4.66253  -52.32317 -31.06411 1.000 27.49842 ? 1258 PHE   B CZ   1 
ATOM   3825 N  N    . ASN   B 2 207 ? -4.15950  -46.46400 -26.36497 1.000 25.21711 ? 1259 ASN   B N    1 
ATOM   3826 C  CA   . ASN   B 2 207 ? -3.58968  -45.36907 -25.58873 1.000 23.40710 ? 1259 ASN   B CA   1 
ATOM   3827 C  C    . ASN   B 2 207 ? -4.59578  -45.02540 -24.50172 1.000 25.13586 ? 1259 ASN   B C    1 
ATOM   3828 O  O    . ASN   B 2 207 ? -5.73672  -45.50054 -24.51788 1.000 25.18353 ? 1259 ASN   B O    1 
ATOM   3829 C  CB   . ASN   B 2 207 ? -3.25978  -44.15087 -26.46649 1.000 24.50399 ? 1259 ASN   B CB   1 
ATOM   3830 C  CG   . ASN   B 2 207 ? -4.44489  -43.18898 -26.61937 1.000 25.02673 ? 1259 ASN   B CG   1 
ATOM   3831 O  OD1  . ASN   B 2 207 ? -4.41105  -42.06708 -26.10216 1.000 22.01832 ? 1259 ASN   B OD1  1 
ATOM   3832 N  ND2  . ASN   B 2 207 ? -5.48379  -43.61597 -27.35751 1.000 21.53131 ? 1259 ASN   B ND2  1 
ATOM   3833 N  N    . MET   B 2 208 ? -4.16493  -44.19853 -23.54354 1.000 26.80835 ? 1260 MET   B N    1 
ATOM   3834 C  CA   . MET   B 2 208 ? -4.98903  -43.93285 -22.36354 1.000 29.44905 ? 1260 MET   B CA   1 
ATOM   3835 C  C    . MET   B 2 208 ? -5.96016  -42.76094 -22.50937 1.000 24.32271 ? 1260 MET   B C    1 
ATOM   3836 O  O    . MET   B 2 208 ? -6.91422  -42.67721 -21.72941 1.000 25.26058 ? 1260 MET   B O    1 
ATOM   3837 C  CB   . MET   B 2 208 ? -4.09512  -43.68398 -21.13744 1.000 26.88467 ? 1260 MET   B CB   1 
ATOM   3838 C  CG   . MET   B 2 208 ? -3.35000  -44.94198 -20.63964 1.000 32.17765 ? 1260 MET   B CG   1 
ATOM   3839 S  SD   . MET   B 2 208 ? -4.39983  -46.41716 -20.37698 1.000 46.07636 ? 1260 MET   B SD   1 
ATOM   3840 C  CE   . MET   B 2 208 ? -5.24397  -46.00955 -18.84495 1.000 51.67152 ? 1260 MET   B CE   1 
ATOM   3841 N  N    . ASN   B 2 209 ? -5.77722  -41.88474 -23.49720 1.000 23.84892 ? 1261 ASN   B N    1 
ATOM   3842 C  CA   . ASN   B 2 209 ? -6.41238  -40.56982 -23.44598 1.000 23.16931 ? 1261 ASN   B CA   1 
ATOM   3843 C  C    . ASN   B 2 209 ? -7.26636  -40.20770 -24.65396 1.000 23.61628 ? 1261 ASN   B C    1 
ATOM   3844 O  O    . ASN   B 2 209 ? -8.37043  -39.68886 -24.48692 1.000 23.87636 ? 1261 ASN   B O    1 
ATOM   3845 C  CB   . ASN   B 2 209 ? -5.33552  -39.50373 -23.26372 1.000 23.52332 ? 1261 ASN   B CB   1 
ATOM   3846 C  CG   . ASN   B 2 209 ? -4.52956  -39.72387 -22.00272 1.000 28.77516 ? 1261 ASN   B CG   1 
ATOM   3847 O  OD1  . ASN   B 2 209 ? -5.10160  -39.85814 -20.91178 1.000 32.11468 ? 1261 ASN   B OD1  1 
ATOM   3848 N  ND2  . ASN   B 2 209 ? -3.20054  -39.81068 -22.14266 1.000 24.50336 ? 1261 ASN   B ND2  1 
ATOM   3849 N  N    . ILE   B 2 210 ? -6.76126  -40.45541 -25.85698 1.000 24.89463 ? 1262 ILE   B N    1 
ATOM   3850 C  CA   . ILE   B 2 210 ? -7.34626  -39.93225 -27.08591 1.000 25.10037 ? 1262 ILE   B CA   1 
ATOM   3851 C  C    . ILE   B 2 210 ? -8.34711  -40.93426 -27.64516 1.000 28.15471 ? 1262 ILE   B C    1 
ATOM   3852 O  O    . ILE   B 2 210 ? -8.00995  -42.10118 -27.87536 1.000 25.03131 ? 1262 ILE   B O    1 
ATOM   3853 C  CB   . ILE   B 2 210 ? -6.24524  -39.62592 -28.11279 1.000 21.40827 ? 1262 ILE   B CB   1 
ATOM   3854 C  CG1  . ILE   B 2 210 ? -5.27040  -38.60491 -27.52555 1.000 27.46032 ? 1262 ILE   B CG1  1 
ATOM   3855 C  CG2  . ILE   B 2 210 ? -6.86823  -39.13674 -29.44174 1.000 23.11840 ? 1262 ILE   B CG2  1 
ATOM   3856 C  CD1  . ILE   B 2 210 ? -5.89358  -37.23903 -27.28732 1.000 27.66341 ? 1262 ILE   B CD1  1 
ATOM   3857 N  N    . SER   B 2 211 ? -9.57015  -40.47137 -27.89413 1.000 24.18107 ? 1263 SER   B N    1 
ATOM   3858 C  CA   . SER   B 2 211 ? -10.62602 -41.33140 -28.39335 1.000 21.60487 ? 1263 SER   B CA   1 
ATOM   3859 C  C    . SER   B 2 211 ? -10.84094 -41.25014 -29.90635 1.000 24.86316 ? 1263 SER   B C    1 
ATOM   3860 O  O    . SER   B 2 211 ? -11.54181 -42.10612 -30.45155 1.000 25.27859 ? 1263 SER   B O    1 
ATOM   3861 C  CB   . SER   B 2 211 ? -11.94210 -41.00770 -27.67636 1.000 25.00813 ? 1263 SER   B CB   1 
ATOM   3862 O  OG   . SER   B 2 211 ? -12.37924 -39.70469 -28.01314 1.000 25.00415 ? 1263 SER   B OG   1 
ATOM   3863 N  N    . GLY   B 2 212 ? -10.31503 -40.23595 -30.58913 1.000 24.99459 ? 1264 GLY   B N    1 
ATOM   3864 C  CA   . GLY   B 2 212 ? -10.28995 -40.22467 -32.04113 1.000 26.58123 ? 1264 GLY   B CA   1 
ATOM   3865 C  C    . GLY   B 2 212 ? -11.33203 -39.31068 -32.67601 1.000 24.59241 ? 1264 GLY   B C    1 
ATOM   3866 O  O    . GLY   B 2 212 ? -12.30412 -38.87491 -32.05598 1.000 25.54468 ? 1264 GLY   B O    1 
ATOM   3867 N  N    . VAL   B 2 213 ? -11.12999 -39.05941 -33.97395 1.000 21.60968 ? 1265 VAL   B N    1 
ATOM   3868 C  CA   . VAL   B 2 213 ? -11.98106 -38.17636 -34.76383 1.000 20.68951 ? 1265 VAL   B CA   1 
ATOM   3869 C  C    . VAL   B 2 213 ? -12.18891 -38.77013 -36.15296 1.000 27.08845 ? 1265 VAL   B C    1 
ATOM   3870 O  O    . VAL   B 2 213 ? -11.43778 -39.63895 -36.60108 1.000 23.33462 ? 1265 VAL   B O    1 
ATOM   3871 C  CB   . VAL   B 2 213 ? -11.36222 -36.77426 -34.91453 1.000 24.96999 ? 1265 VAL   B CB   1 
ATOM   3872 C  CG1  . VAL   B 2 213 ? -11.14137 -36.12549 -33.54140 1.000 24.44017 ? 1265 VAL   B CG1  1 
ATOM   3873 C  CG2  . VAL   B 2 213 ? -10.05816 -36.87495 -35.69948 1.000 24.48138 ? 1265 VAL   B CG2  1 
ATOM   3874 N  N    . PHE   B 2 214 ? -13.20993 -38.26812 -36.84492 1.000 21.55851 ? 1266 PHE   B N    1 
ATOM   3875 C  CA   . PHE   B 2 214 ? -13.43081 -38.61188 -38.23799 1.000 22.17946 ? 1266 PHE   B CA   1 
ATOM   3876 C  C    . PHE   B 2 214 ? -12.54187 -37.77760 -39.15279 1.000 30.98730 ? 1266 PHE   B C    1 
ATOM   3877 O  O    . PHE   B 2 214 ? -12.37202 -36.57162 -38.94955 1.000 25.56724 ? 1266 PHE   B O    1 
ATOM   3878 C  CB   . PHE   B 2 214 ? -14.88982 -38.38799 -38.61803 1.000 21.70643 ? 1266 PHE   B CB   1 
ATOM   3879 C  CG   . PHE   B 2 214 ? -15.83574 -39.33923 -37.96326 1.000 25.90043 ? 1266 PHE   B CG   1 
ATOM   3880 C  CD1  . PHE   B 2 214 ? -16.02156 -40.62015 -38.47451 1.000 24.74499 ? 1266 PHE   B CD1  1 
ATOM   3881 C  CD2  . PHE   B 2 214 ? -16.53885 -38.96053 -36.83523 1.000 23.36992 ? 1266 PHE   B CD2  1 
ATOM   3882 C  CE1  . PHE   B 2 214 ? -16.89448 -41.49737 -37.86973 1.000 26.74857 ? 1266 PHE   B CE1  1 
ATOM   3883 C  CE2  . PHE   B 2 214 ? -17.41078 -39.82575 -36.21544 1.000 25.30840 ? 1266 PHE   B CE2  1 
ATOM   3884 C  CZ   . PHE   B 2 214 ? -17.59759 -41.10667 -36.73569 1.000 28.06004 ? 1266 PHE   B CZ   1 
ATOM   3885 N  N    . HIS   B 2 215 ? -11.97273 -38.42434 -40.16788 1.000 23.51631 ? 1267 HIS   B N    1 
ATOM   3886 C  CA   . HIS   B 2 215 ? -11.35276 -37.67106 -41.25570 1.000 25.54737 ? 1267 HIS   B CA   1 
ATOM   3887 C  C    . HIS   B 2 215 ? -12.44981 -36.97204 -42.05963 1.000 23.96137 ? 1267 HIS   B C    1 
ATOM   3888 O  O    . HIS   B 2 215 ? -13.55873 -37.50215 -42.18679 1.000 26.31522 ? 1267 HIS   B O    1 
ATOM   3889 C  CB   . HIS   B 2 215 ? -10.53560 -38.62079 -42.13784 1.000 27.43669 ? 1267 HIS   B CB   1 
ATOM   3890 C  CG   . HIS   B 2 215 ? -9.72262  -37.94549 -43.20267 1.000 27.02850 ? 1267 HIS   B CG   1 
ATOM   3891 N  ND1  . HIS   B 2 215 ? -10.29365 -37.26736 -44.26057 1.000 27.18115 ? 1267 HIS   B ND1  1 
ATOM   3892 C  CD2  . HIS   B 2 215 ? -8.38162  -37.89929 -43.40358 1.000 23.66822 ? 1267 HIS   B CD2  1 
ATOM   3893 C  CE1  . HIS   B 2 215 ? -9.33866  -36.80910 -45.05143 1.000 31.23076 ? 1267 HIS   B CE1  1 
ATOM   3894 N  NE2  . HIS   B 2 215 ? -8.17064  -37.18005 -44.55644 1.000 28.64573 ? 1267 HIS   B NE2  1 
ATOM   3895 N  N    . PRO   B 2 216 ? -12.19893 -35.76291 -42.57339 1.000 27.18014 ? 1268 PRO   B N    1 
ATOM   3896 C  CA   . PRO   B 2 216 ? -13.25397 -35.06990 -43.33631 1.000 31.31960 ? 1268 PRO   B CA   1 
ATOM   3897 C  C    . PRO   B 2 216 ? -13.71681 -35.81772 -44.58248 1.000 28.89773 ? 1268 PRO   B C    1 
ATOM   3898 O  O    . PRO   B 2 216 ? -14.79882 -35.51175 -45.09148 1.000 27.73004 ? 1268 PRO   B O    1 
ATOM   3899 C  CB   . PRO   B 2 216 ? -12.61611 -33.71275 -43.68802 1.000 29.77652 ? 1268 PRO   B CB   1 
ATOM   3900 C  CG   . PRO   B 2 216 ? -11.17312 -33.84964 -43.36597 1.000 32.91879 ? 1268 PRO   B CG   1 
ATOM   3901 C  CD   . PRO   B 2 216 ? -11.06505 -34.87383 -42.28116 1.000 26.41097 ? 1268 PRO   B CD   1 
ATOM   3902 N  N    . ASN   B 2 217 ? -12.95766 -36.80253 -45.08163 1.000 25.74041 ? 1269 ASN   B N    1 
ATOM   3903 C  CA   . ASN   B 2 217 ? -13.42651 -37.57237 -46.23580 1.000 32.10875 ? 1269 ASN   B CA   1 
ATOM   3904 C  C    . ASN   B 2 217 ? -14.54140 -38.55457 -45.88504 1.000 33.43119 ? 1269 ASN   B C    1 
ATOM   3905 O  O    . ASN   B 2 217 ? -15.16029 -39.12148 -46.79318 1.000 32.14264 ? 1269 ASN   B O    1 
ATOM   3906 C  CB   . ASN   B 2 217 ? -12.25538 -38.31110 -46.90187 1.000 29.94895 ? 1269 ASN   B CB   1 
ATOM   3907 C  CG   . ASN   B 2 217 ? -11.62730 -39.38920 -46.00704 1.000 35.09504 ? 1269 ASN   B CG   1 
ATOM   3908 O  OD1  . ASN   B 2 217 ? -12.25428 -39.91045 -45.07617 1.000 31.00471 ? 1269 ASN   B OD1  1 
ATOM   3909 N  ND2  . ASN   B 2 217 ? -10.37524 -39.73899 -46.31004 1.000 31.35174 ? 1269 ASN   B ND2  1 
ATOM   3910 N  N    . GLY   B 2 218 ? -14.82845 -38.75985 -44.60210 1.000 29.09855 ? 1270 GLY   B N    1 
ATOM   3911 C  CA   . GLY   B 2 218 ? -15.92037 -39.61706 -44.21332 1.000 27.87520 ? 1270 GLY   B CA   1 
ATOM   3912 C  C    . GLY   B 2 218 ? -15.63418 -41.09901 -44.29258 1.000 28.83539 ? 1270 GLY   B C    1 
ATOM   3913 O  O    . GLY   B 2 218 ? -16.54610 -41.89517 -44.03778 1.000 31.16434 ? 1270 GLY   B O    1 
ATOM   3914 N  N    . LEU   B 2 219 ? -14.40411 -41.50279 -44.62759 1.000 29.43169 ? 1271 LEU   B N    1 
ATOM   3915 C  CA   . LEU   B 2 219 ? -14.10993 -42.91171 -44.87684 1.000 31.47414 ? 1271 LEU   B CA   1 
ATOM   3916 C  C    . LEU   B 2 219 ? -13.02191 -43.48775 -43.97789 1.000 28.04552 ? 1271 LEU   B C    1 
ATOM   3917 O  O    . LEU   B 2 219 ? -12.75176 -44.69770 -44.05711 1.000 27.22571 ? 1271 LEU   B O    1 
ATOM   3918 C  CB   . LEU   B 2 219 ? -13.73682 -43.11739 -46.35986 1.000 35.20640 ? 1271 LEU   B CB   1 
ATOM   3919 C  CG   . LEU   B 2 219 ? -14.91979 -42.91134 -47.33989 1.000 38.49511 ? 1271 LEU   B CG   1 
ATOM   3920 C  CD1  . LEU   B 2 219 ? -14.52069 -43.13802 -48.80491 1.000 39.98710 ? 1271 LEU   B CD1  1 
ATOM   3921 C  CD2  . LEU   B 2 219 ? -16.13271 -43.78356 -46.97212 1.000 36.97927 ? 1271 LEU   B CD2  1 
ATOM   3922 N  N    . GLU   B 2 220 ? -12.42505 -42.67484 -43.10471 1.000 26.89255 ? 1272 GLU   B N    1 
ATOM   3923 C  CA   . GLU   B 2 220 ? -11.37005 -43.08789 -42.18273 1.000 26.33984 ? 1272 GLU   B CA   1 
ATOM   3924 C  C    . GLU   B 2 220 ? -11.59821 -42.43217 -40.82762 1.000 24.32948 ? 1272 GLU   B C    1 
ATOM   3925 O  O    . GLU   B 2 220 ? -12.18634 -41.35126 -40.73844 1.000 23.27513 ? 1272 GLU   B O    1 
ATOM   3926 C  CB   . GLU   B 2 220 ? -9.96708  -42.64463 -42.63957 1.000 25.95856 ? 1272 GLU   B CB   1 
ATOM   3927 C  CG   . GLU   B 2 220 ? -9.54596  -43.05432 -44.00362 1.000 41.76926 ? 1272 GLU   B CG   1 
ATOM   3928 C  CD   . GLU   B 2 220 ? -8.52304  -42.09709 -44.58438 1.000 32.20297 ? 1272 GLU   B CD   1 
ATOM   3929 O  OE1  . GLU   B 2 220 ? -7.54513  -41.72510 -43.89226 1.000 32.27511 ? 1272 GLU   B OE1  1 
ATOM   3930 O  OE2  . GLU   B 2 220 ? -8.71303  -41.69489 -45.73832 1.000 47.79625 ? 1272 GLU   B OE2  1 
ATOM   3931 N  N    . VAL   B 2 221 ? -11.12918 -43.08831 -39.76771 1.000 23.66606 ? 1273 VAL   B N    1 
ATOM   3932 C  CA   . VAL   B 2 221 ? -11.06733 -42.45655 -38.45459 1.000 26.05475 ? 1273 VAL   B CA   1 
ATOM   3933 C  C    . VAL   B 2 221 ? -9.62136  -42.40946 -38.00350 1.000 29.17973 ? 1273 VAL   B C    1 
ATOM   3934 O  O    . VAL   B 2 221 ? -8.82824  -43.32031 -38.28763 1.000 27.88177 ? 1273 VAL   B O    1 
ATOM   3935 C  CB   . VAL   B 2 221 ? -11.94431 -43.14486 -37.39077 1.000 27.34161 ? 1273 VAL   B CB   1 
ATOM   3936 C  CG1  . VAL   B 2 221 ? -13.39932 -42.92398 -37.71881 1.000 23.59179 ? 1273 VAL   B CG1  1 
ATOM   3937 C  CG2  . VAL   B 2 221 ? -11.59113 -44.63585 -37.24003 1.000 23.98634 ? 1273 VAL   B CG2  1 
ATOM   3938 N  N    . ILE   B 2 222 ? -9.28353  -41.32255 -37.32328 1.000 22.70168 ? 1274 ILE   B N    1 
ATOM   3939 C  CA   . ILE   B 2 222 ? -7.95659  -41.07449 -36.78416 1.000 24.18453 ? 1274 ILE   B CA   1 
ATOM   3940 C  C    . ILE   B 2 222 ? -8.06466  -41.20479 -35.27319 1.000 26.88404 ? 1274 ILE   B C    1 
ATOM   3941 O  O    . ILE   B 2 222 ? -8.63180  -40.32598 -34.61306 1.000 24.68614 ? 1274 ILE   B O    1 
ATOM   3942 C  CB   . ILE   B 2 222 ? -7.44874  -39.67836 -37.17287 1.000 19.90784 ? 1274 ILE   B CB   1 
ATOM   3943 C  CG1  . ILE   B 2 222 ? -7.52768  -39.49808 -38.69284 1.000 26.66741 ? 1274 ILE   B CG1  1 
ATOM   3944 C  CG2  . ILE   B 2 222 ? -6.03780  -39.46928 -36.64575 1.000 24.29635 ? 1274 ILE   B CG2  1 
ATOM   3945 C  CD1  . ILE   B 2 222 ? -7.88583  -38.10004 -39.12760 1.000 28.18497 ? 1274 ILE   B CD1  1 
ATOM   3946 N  N    . ILE   B 2 223 ? -7.53356  -42.28383 -34.71737 1.000 23.37207 ? 1275 ILE   B N    1 
ATOM   3947 C  CA   . ILE   B 2 223 ? -7.64660  -42.57111 -33.29043 1.000 23.89392 ? 1275 ILE   B CA   1 
ATOM   3948 C  C    . ILE   B 2 223 ? -6.21962  -42.63804 -32.76536 1.000 21.24677 ? 1275 ILE   B C    1 
ATOM   3949 O  O    . ILE   B 2 223 ? -5.56649  -43.68495 -32.79552 1.000 23.83082 ? 1275 ILE   B O    1 
ATOM   3950 C  CB   . ILE   B 2 223 ? -8.41846  -43.86226 -33.00971 1.000 25.79459 ? 1275 ILE   B CB   1 
ATOM   3951 C  CG1  . ILE   B 2 223 ? -9.78743  -43.80830 -33.69178 1.000 27.03752 ? 1275 ILE   B CG1  1 
ATOM   3952 C  CG2  . ILE   B 2 223 ? -8.58551  -44.07956 -31.51076 1.000 24.00194 ? 1275 ILE   B CG2  1 
ATOM   3953 C  CD1  . ILE   B 2 223 ? -10.66929 -45.03046 -33.40306 1.000 24.55891 ? 1275 ILE   B CD1  1 
ATOM   3954 N  N    . ASN   B 2 224 ? -5.72078  -41.50007 -32.28712 1.000 22.43812 ? 1276 ASN   B N    1 
ATOM   3955 C  CA   . ASN   B 2 224 ? -4.34683  -41.37899 -31.80002 1.000 22.57894 ? 1276 ASN   B CA   1 
ATOM   3956 C  C    . ASN   B 2 224 ? -3.43072  -41.73966 -32.96304 1.000 24.82368 ? 1276 ASN   B C    1 
ATOM   3957 O  O    . ASN   B 2 224 ? -3.55774  -41.11947 -34.03493 1.000 24.18221 ? 1276 ASN   B O    1 
ATOM   3958 C  CB   . ASN   B 2 224 ? -4.16879  -42.21621 -30.53117 1.000 20.31040 ? 1276 ASN   B CB   1 
ATOM   3959 C  CG   . ASN   B 2 224 ? -2.99690  -41.73723 -29.69302 1.000 26.47908 ? 1276 ASN   B CG   1 
ATOM   3960 O  OD1  . ASN   B 2 224 ? -2.89006  -40.54427 -29.39979 1.000 23.29348 ? 1276 ASN   B OD1  1 
ATOM   3961 N  ND2  . ASN   B 2 224 ? -2.09781  -42.65018 -29.33514 1.000 24.77210 ? 1276 ASN   B ND2  1 
ATOM   3962 N  N    . THR   B 2 225 ? -2.54361  -42.72258 -32.83018 1.000 24.28840 ? 1277 THR   B N    1 
ATOM   3963 C  CA   . THR   B 2 225 ? -1.60650  -43.09526 -33.89020 1.000 25.38945 ? 1277 THR   B CA   1 
ATOM   3964 C  C    . THR   B 2 225 ? -2.19733  -44.03414 -34.94141 1.000 25.79590 ? 1277 THR   B C    1 
ATOM   3965 O  O    . THR   B 2 225 ? -1.47424  -44.40987 -35.87044 1.000 26.10086 ? 1277 THR   B O    1 
ATOM   3966 C  CB   . THR   B 2 225 ? -0.37046  -43.75523 -33.27826 1.000 21.78239 ? 1277 THR   B CB   1 
ATOM   3967 O  OG1  . THR   B 2 225 ? -0.79037  -44.83344 -32.43348 1.000 26.63677 ? 1277 THR   B OG1  1 
ATOM   3968 C  CG2  . THR   B 2 225 ? 0.39838   -42.76430 -32.42303 1.000 24.93257 ? 1277 THR   B CG2  1 
ATOM   3969 N  N    . GLU   B 2 226 ? -3.46529  -44.42631 -34.83255 1.000 23.79150 ? 1278 GLU   B N    1 
ATOM   3970 C  CA   . GLU   B 2 226 ? -4.05212  -45.42722 -35.71677 1.000 25.76223 ? 1278 GLU   B CA   1 
ATOM   3971 C  C    . GLU   B 2 226 ? -5.02315  -44.76515 -36.68470 1.000 26.84161 ? 1278 GLU   B C    1 
ATOM   3972 O  O    . GLU   B 2 226 ? -5.93226  -44.04334 -36.25961 1.000 25.21974 ? 1278 GLU   B O    1 
ATOM   3973 C  CB   . GLU   B 2 226 ? -4.78103  -46.51646 -34.91402 1.000 24.11838 ? 1278 GLU   B CB   1 
ATOM   3974 C  CG   . GLU   B 2 226 ? -3.87893  -47.58546 -34.29617 1.000 24.66670 ? 1278 GLU   B CG   1 
ATOM   3975 C  CD   . GLU   B 2 226 ? -2.92406  -47.01654 -33.25701 1.000 23.50889 ? 1278 GLU   B CD   1 
ATOM   3976 O  OE1  . GLU   B 2 226 ? -3.37416  -46.71281 -32.12198 1.000 24.44118 ? 1278 GLU   B OE1  1 
ATOM   3977 O  OE2  . GLU   B 2 226 ? -1.73106  -46.85934 -33.58792 1.000 25.39191 ? 1278 GLU   B OE2  1 
ATOM   3978 N  N    . ILE   B 2 227 ? -4.83905  -45.01689 -37.97574 1.000 23.88571 ? 1279 ILE   B N    1 
ATOM   3979 C  CA   . ILE   B 2 227 ? -5.81304  -44.62981 -38.99572 1.000 21.59203 ? 1279 ILE   B CA   1 
ATOM   3980 C  C    . ILE   B 2 227 ? -6.55686  -45.89282 -39.40800 1.000 25.49311 ? 1279 ILE   B C    1 
ATOM   3981 O  O    . ILE   B 2 227 ? -5.96772  -46.79064 -40.01813 1.000 26.27797 ? 1279 ILE   B O    1 
ATOM   3982 C  CB   . ILE   B 2 227 ? -5.15905  -43.98450 -40.22056 1.000 25.01176 ? 1279 ILE   B CB   1 
ATOM   3983 C  CG1  . ILE   B 2 227 ? -4.08120  -42.96844 -39.83231 1.000 32.21144 ? 1279 ILE   B CG1  1 
ATOM   3984 C  CG2  . ILE   B 2 227 ? -6.23508  -43.38347 -41.09650 1.000 26.30363 ? 1279 ILE   B CG2  1 
ATOM   3985 C  CD1  . ILE   B 2 227 ? -4.49937  -41.98969 -38.76915 1.000 31.08277 ? 1279 ILE   B CD1  1 
ATOM   3986 N  N    . TRP   B 2 228 ? -7.84787  -45.96404 -39.10308 1.000 25.25046 ? 1280 TRP   B N    1 
ATOM   3987 C  CA   . TRP   B 2 228 ? -8.65971  -47.13208 -39.43434 1.000 21.87356 ? 1280 TRP   B CA   1 
ATOM   3988 C  C    . TRP   B 2 228 ? -9.55768  -46.83796 -40.63234 1.000 29.28371 ? 1280 TRP   B C    1 
ATOM   3989 O  O    . TRP   B 2 228 ? -10.14281 -45.75901 -40.73016 1.000 24.84048 ? 1280 TRP   B O    1 
ATOM   3990 C  CB   . TRP   B 2 228 ? -9.53572  -47.55941 -38.25347 1.000 21.08079 ? 1280 TRP   B CB   1 
ATOM   3991 C  CG   . TRP   B 2 228 ? -8.80675  -47.90456 -36.98850 1.000 23.96511 ? 1280 TRP   B CG   1 
ATOM   3992 C  CD1  . TRP   B 2 228 ? -8.73590  -47.14576 -35.85135 1.000 27.26272 ? 1280 TRP   B CD1  1 
ATOM   3993 C  CD2  . TRP   B 2 228 ? -8.08762  -49.11552 -36.70669 1.000 28.42761 ? 1280 TRP   B CD2  1 
ATOM   3994 N  NE1  . TRP   B 2 228 ? -8.00788  -47.79986 -34.88743 1.000 25.02527 ? 1280 TRP   B NE1  1 
ATOM   3995 C  CE2  . TRP   B 2 228 ? -7.59070  -49.00871 -35.38664 1.000 27.49490 ? 1280 TRP   B CE2  1 
ATOM   3996 C  CE3  . TRP   B 2 228 ? -7.80544  -50.27635 -37.44089 1.000 28.07497 ? 1280 TRP   B CE3  1 
ATOM   3997 C  CZ2  . TRP   B 2 228 ? -6.83661  -50.01773 -34.78979 1.000 29.25237 ? 1280 TRP   B CZ2  1 
ATOM   3998 C  CZ3  . TRP   B 2 228 ? -7.04935  -51.27737 -36.84604 1.000 30.59726 ? 1280 TRP   B CZ3  1 
ATOM   3999 C  CH2  . TRP   B 2 228 ? -6.57443  -51.13956 -35.53399 1.000 36.01507 ? 1280 TRP   B CH2  1 
ATOM   4000 N  N    . ASP   B 2 229 ? -9.68051  -47.81280 -41.52953 1.000 25.48266 ? 1281 ASP   B N    1 
ATOM   4001 C  CA   . ASP   B 2 229 ? -10.57546 -47.70270 -42.67456 1.000 32.37460 ? 1281 ASP   B CA   1 
ATOM   4002 C  C    . ASP   B 2 229 ? -12.00846 -47.97896 -42.22469 1.000 26.06007 ? 1281 ASP   B C    1 
ATOM   4003 O  O    . ASP   B 2 229 ? -12.27836 -49.01511 -41.60290 1.000 29.05074 ? 1281 ASP   B O    1 
ATOM   4004 C  CB   . ASP   B 2 229 ? -10.14028 -48.70044 -43.75672 1.000 28.16571 ? 1281 ASP   B CB   1 
ATOM   4005 C  CG   . ASP   B 2 229 ? -10.76624 -48.42826 -45.12770 1.000 32.86377 ? 1281 ASP   B CG   1 
ATOM   4006 O  OD1  . ASP   B 2 229 ? -11.85831 -47.82837 -45.21965 1.000 27.70057 ? 1281 ASP   B OD1  1 
ATOM   4007 O  OD2  . ASP   B 2 229 ? -10.14414 -48.83399 -46.13275 1.000 37.36181 ? 1281 ASP   B OD2  1 
ATOM   4008 N  N    . LEU   B 2 230 ? -12.92855 -47.05501 -42.52156 1.000 23.75174 ? 1282 LEU   B N    1 
ATOM   4009 C  CA   . LEU   B 2 230 ? -14.33554 -47.28625 -42.19268 1.000 24.38499 ? 1282 LEU   B CA   1 
ATOM   4010 C  C    . LEU   B 2 230 ? -15.03437 -48.24815 -43.15290 1.000 28.18726 ? 1282 LEU   B C    1 
ATOM   4011 O  O    . LEU   B 2 230 ? -16.14633 -48.69634 -42.85605 1.000 30.24776 ? 1282 LEU   B O    1 
ATOM   4012 C  CB   . LEU   B 2 230 ? -15.12370 -45.97135 -42.16948 1.000 29.61028 ? 1282 LEU   B CB   1 
ATOM   4013 C  CG   . LEU   B 2 230 ? -14.90988 -45.07355 -40.95029 1.000 28.26751 ? 1282 LEU   B CG   1 
ATOM   4014 C  CD1  . LEU   B 2 230 ? -15.76702 -43.82864 -41.05411 1.000 26.79514 ? 1282 LEU   B CD1  1 
ATOM   4015 C  CD2  . LEU   B 2 230 ? -15.19685 -45.84083 -39.66445 1.000 27.60659 ? 1282 LEU   B CD2  1 
ATOM   4016 N  N    . ARG   B 2 231 ? -14.43427 -48.55186 -44.29693 1.000 27.79449 ? 1283 ARG   B N    1 
ATOM   4017 C  CA   . ARG   B 2 231 ? -15.02210 -49.53976 -45.23114 1.000 29.18007 ? 1283 ARG   B CA   1 
ATOM   4018 C  C    . ARG   B 2 231 ? -14.74295 -50.96581 -44.76340 1.000 32.20976 ? 1283 ARG   B C    1 
ATOM   4019 O  O    . ARG   B 2 231 ? -15.58883 -51.83287 -45.00261 1.000 32.68781 ? 1283 ARG   B O    1 
ATOM   4020 C  CB   . ARG   B 2 231 ? -14.34704 -49.46942 -46.60009 1.000 31.80013 ? 1283 ARG   B CB   1 
ATOM   4021 C  CG   . ARG   B 2 231 ? -14.30416 -48.14527 -47.34184 1.000 37.70916 ? 1283 ARG   B CG   1 
ATOM   4022 C  CD   . ARG   B 2 231 ? -13.10110 -48.20595 -48.26379 1.000 41.72305 ? 1283 ARG   B CD   1 
ATOM   4023 N  NE   . ARG   B 2 231 ? -12.88421 -46.95279 -48.98854 1.000 46.08792 ? 1283 ARG   B NE   1 
ATOM   4024 C  CZ   . ARG   B 2 231 ? -12.14836 -45.95378 -48.53431 1.000 49.51436 ? 1283 ARG   B CZ   1 
ATOM   4025 N  NH1  . ARG   B 2 231 ? -11.76543 -45.93297 -47.27229 1.000 44.43067 ? 1283 ARG   B NH1  1 
ATOM   4026 N  NH2  . ARG   B 2 231 ? -11.80043 -44.97659 -49.34811 1.000 49.67690 ? 1283 ARG   B NH2  1 
ATOM   4027 N  N    . THR   B 2 232 ? -13.61996 -51.18080 -44.09438 1.000 33.05400 ? 1284 THR   B N    1 
ATOM   4028 C  CA   . THR   B 2 232 ? -13.15582 -52.52081 -43.73561 1.000 36.07691 ? 1284 THR   B CA   1 
ATOM   4029 C  C    . THR   B 2 232 ? -12.68388 -52.65902 -42.29961 1.000 31.08565 ? 1284 THR   B C    1 
ATOM   4030 O  O    . THR   B 2 232 ? -12.51777 -53.79509 -41.83381 1.000 29.80198 ? 1284 THR   B O    1 
ATOM   4031 C  CB   . THR   B 2 232 ? -11.99072 -52.93550 -44.63562 1.000 33.98952 ? 1284 THR   B CB   1 
ATOM   4032 O  OG1  . THR   B 2 232 ? -10.90884 -52.02641 -44.42139 1.000 31.41816 ? 1284 THR   B OG1  1 
ATOM   4033 C  CG2  . THR   B 2 232 ? -12.40465 -52.89127 -46.10364 1.000 32.26833 ? 1284 THR   B CG2  1 
ATOM   4034 N  N    . PHE   B 2 233 ? -12.42305 -51.56013 -41.59638 1.000 31.23080 ? 1285 PHE   B N    1 
ATOM   4035 C  CA   . PHE   B 2 233 ? -11.80512 -51.57430 -40.27235 1.000 29.55881 ? 1285 PHE   B CA   1 
ATOM   4036 C  C    . PHE   B 2 233 ? -10.37706 -52.09212 -40.29337 1.000 31.06485 ? 1285 PHE   B C    1 
ATOM   4037 O  O    . PHE   B 2 233 ? -9.84407  -52.45926 -39.24441 1.000 33.44553 ? 1285 PHE   B O    1 
ATOM   4038 C  CB   . PHE   B 2 233 ? -12.65108 -52.37459 -39.28355 1.000 34.67435 ? 1285 PHE   B CB   1 
ATOM   4039 C  CG   . PHE   B 2 233 ? -14.04315 -51.87278 -39.19353 1.000 36.31465 ? 1285 PHE   B CG   1 
ATOM   4040 C  CD1  . PHE   B 2 233 ? -14.28032 -50.52985 -38.94329 1.000 34.13540 ? 1285 PHE   B CD1  1 
ATOM   4041 C  CD2  . PHE   B 2 233 ? -15.11603 -52.70986 -39.43175 1.000 38.39426 ? 1285 PHE   B CD2  1 
ATOM   4042 C  CE1  . PHE   B 2 233 ? -15.56439 -50.04102 -38.88427 1.000 34.58398 ? 1285 PHE   B CE1  1 
ATOM   4043 C  CE2  . PHE   B 2 233 ? -16.41309 -52.21903 -39.37873 1.000 41.41595 ? 1285 PHE   B CE2  1 
ATOM   4044 C  CZ   . PHE   B 2 233 ? -16.63227 -50.88511 -39.10249 1.000 33.72797 ? 1285 PHE   B CZ   1 
ATOM   4045 N  N    . HIS   B 2 234 ? -9.73699  -52.11082 -41.46334 1.000 31.11973 ? 1286 HIS   B N    1 
ATOM   4046 C  CA   . HIS   B 2 234 ? -8.30696  -52.38564 -41.53332 1.000 29.84499 ? 1286 HIS   B CA   1 
ATOM   4047 C  C    . HIS   B 2 234 ? -7.50613  -51.17262 -41.08004 1.000 28.97898 ? 1286 HIS   B C    1 
ATOM   4048 O  O    . HIS   B 2 234 ? -7.95826  -50.02866 -41.19185 1.000 29.18674 ? 1286 HIS   B O    1 
ATOM   4049 C  CB   . HIS   B 2 234 ? -7.87183  -52.74131 -42.95736 1.000 31.67544 ? 1286 HIS   B CB   1 
ATOM   4050 C  CG   . HIS   B 2 234 ? -8.38165  -54.06528 -43.44264 1.000 35.16068 ? 1286 HIS   B CG   1 
ATOM   4051 N  ND1  . HIS   B 2 234 ? -7.92251  -54.65601 -44.60173 1.000 40.74258 ? 1286 HIS   B ND1  1 
ATOM   4052 C  CD2  . HIS   B 2 234 ? -9.30357  -54.91349 -42.92785 1.000 32.73029 ? 1286 HIS   B CD2  1 
ATOM   4053 C  CE1  . HIS   B 2 234 ? -8.54336  -55.80805 -44.77998 1.000 37.79662 ? 1286 HIS   B CE1  1 
ATOM   4054 N  NE2  . HIS   B 2 234 ? -9.38639  -55.98834 -43.77806 1.000 37.78873 ? 1286 HIS   B NE2  1 
ATOM   4055 N  N    . LEU   B 2 235 ? -6.29312  -51.43257 -40.58703 1.000 27.77341 ? 1287 LEU   B N    1 
ATOM   4056 C  CA   . LEU   B 2 235 ? -5.35327  -50.36952 -40.25378 1.000 28.24326 ? 1287 LEU   B CA   1 
ATOM   4057 C  C    . LEU   B 2 235 ? -4.72126  -49.85520 -41.54064 1.000 33.82551 ? 1287 LEU   B C    1 
ATOM   4058 O  O    . LEU   B 2 235 ? -3.93014  -50.56398 -42.17474 1.000 33.64939 ? 1287 LEU   B O    1 
ATOM   4059 C  CB   . LEU   B 2 235 ? -4.28226  -50.87657 -39.29081 1.000 26.30045 ? 1287 LEU   B CB   1 
ATOM   4060 C  CG   . LEU   B 2 235 ? -3.31642  -49.80755 -38.77356 1.000 30.02237 ? 1287 LEU   B CG   1 
ATOM   4061 C  CD1  . LEU   B 2 235 ? -4.08159  -48.77181 -37.90840 1.000 26.35440 ? 1287 LEU   B CD1  1 
ATOM   4062 C  CD2  . LEU   B 2 235 ? -2.16639  -50.43056 -37.98961 1.000 25.17754 ? 1287 LEU   B CD2  1 
ATOM   4063 N  N    . LEU   B 2 236 ? -5.05539  -48.61517 -41.91343 1.000 27.68238 ? 1288 LEU   B N    1 
ATOM   4064 C  CA   . LEU   B 2 236 ? -4.47441  -47.97287 -43.09328 1.000 29.75065 ? 1288 LEU   B CA   1 
ATOM   4065 C  C    . LEU   B 2 236 ? -3.10450  -47.36076 -42.81009 1.000 28.38089 ? 1288 LEU   B C    1 
ATOM   4066 O  O    . LEU   B 2 236 ? -2.21945  -47.39749 -43.67404 1.000 28.87005 ? 1288 LEU   B O    1 
ATOM   4067 C  CB   . LEU   B 2 236 ? -5.41151  -46.88089 -43.61612 1.000 25.71711 ? 1288 LEU   B CB   1 
ATOM   4068 C  CG   . LEU   B 2 236 ? -6.77143  -47.34296 -44.14128 1.000 31.60189 ? 1288 LEU   B CG   1 
ATOM   4069 C  CD1  . LEU   B 2 236 ? -7.60555  -46.14998 -44.57410 1.000 28.50099 ? 1288 LEU   B CD1  1 
ATOM   4070 C  CD2  . LEU   B 2 236 ? -6.60025  -48.32772 -45.28946 1.000 31.07949 ? 1288 LEU   B CD2  1 
ATOM   4071 N  N    . HIS   B 2 237 ? -2.92464  -46.73196 -41.64696 1.000 27.17769 ? 1289 HIS   B N    1 
ATOM   4072 C  CA   . HIS   B 2 237 ? -1.66974  -46.04386 -41.37476 1.000 27.61171 ? 1289 HIS   B CA   1 
ATOM   4073 C  C    . HIS   B 2 237 ? -1.32981  -46.13009 -39.89976 1.000 25.66784 ? 1289 HIS   B C    1 
ATOM   4074 O  O    . HIS   B 2 237 ? -2.21585  -46.16436 -39.03981 1.000 25.58136 ? 1289 HIS   B O    1 
ATOM   4075 C  CB   . HIS   B 2 237 ? -1.70290  -44.56179 -41.76948 1.000 25.57732 ? 1289 HIS   B CB   1 
ATOM   4076 C  CG   . HIS   B 2 237 ? -1.97985  -44.31855 -43.21745 1.000 31.49268 ? 1289 HIS   B CG   1 
ATOM   4077 N  ND1  . HIS   B 2 237 ? -0.99379  -44.35524 -44.17840 1.000 35.62127 ? 1289 HIS   B ND1  1 
ATOM   4078 C  CD2  . HIS   B 2 237 ? -3.13185  -44.02456 -43.86946 1.000 32.69190 ? 1289 HIS   B CD2  1 
ATOM   4079 C  CE1  . HIS   B 2 237 ? -1.52576  -44.09309 -45.35938 1.000 35.11194 ? 1289 HIS   B CE1  1 
ATOM   4080 N  NE2  . HIS   B 2 237 ? -2.81979  -43.88827 -45.20041 1.000 35.05004 ? 1289 HIS   B NE2  1 
ATOM   4081 N  N    . THR   B 2 238 ? -0.03182  -46.15599 -39.62569 1.000 21.13097 ? 1290 THR   B N    1 
ATOM   4082 C  CA   . THR   B 2 238 ? 0.52308   -45.91517 -38.30061 1.000 26.87922 ? 1290 THR   B CA   1 
ATOM   4083 C  C    . THR   B 2 238 ? 1.22292   -44.56707 -38.35632 1.000 28.24126 ? 1290 THR   B C    1 
ATOM   4084 O  O    . THR   B 2 238 ? 2.13694   -44.37581 -39.16124 1.000 26.15217 ? 1290 THR   B O    1 
ATOM   4085 C  CB   . THR   B 2 238 ? 1.51219   -47.01613 -37.89677 1.000 31.33664 ? 1290 THR   B CB   1 
ATOM   4086 O  OG1  . THR   B 2 238 ? 0.82634   -48.26923 -37.76804 1.000 26.83484 ? 1290 THR   B OG1  1 
ATOM   4087 C  CG2  . THR   B 2 238 ? 2.18808   -46.67429 -36.58367 1.000 27.50886 ? 1290 THR   B CG2  1 
ATOM   4088 N  N    . VAL   B 2 239 ? 0.78876   -43.62828 -37.52717 1.000 24.89444 ? 1291 VAL   B N    1 
ATOM   4089 C  CA   . VAL   B 2 239 ? 1.35760   -42.28320 -37.59388 1.000 26.22033 ? 1291 VAL   B CA   1 
ATOM   4090 C  C    . VAL   B 2 239 ? 1.87548   -41.91540 -36.21279 1.000 25.59722 ? 1291 VAL   B C    1 
ATOM   4091 O  O    . VAL   B 2 239 ? 1.15836   -41.27364 -35.42970 1.000 25.23553 ? 1291 VAL   B O    1 
ATOM   4092 C  CB   . VAL   B 2 239 ? 0.34050   -41.25323 -38.10074 1.000 27.96413 ? 1291 VAL   B CB   1 
ATOM   4093 C  CG1  . VAL   B 2 239 ? 1.04135   -39.89610 -38.32345 1.000 27.69835 ? 1291 VAL   B CG1  1 
ATOM   4094 C  CG2  . VAL   B 2 239 ? -0.33337  -41.75807 -39.38288 1.000 25.35552 ? 1291 VAL   B CG2  1 
ATOM   4095 N  N    . PRO   B 2 240 ? 3.10451   -42.30931 -35.87279 1.000 27.16820 ? 1292 PRO   B N    1 
ATOM   4096 C  CA   . PRO   B 2 240 ? 3.57441   -42.13252 -34.49073 1.000 26.76270 ? 1292 PRO   B CA   1 
ATOM   4097 C  C    . PRO   B 2 240 ? 3.48821   -40.69862 -34.02647 1.000 30.93531 ? 1292 PRO   B C    1 
ATOM   4098 O  O    . PRO   B 2 240 ? 3.21512   -40.44987 -32.84344 1.000 26.15776 ? 1292 PRO   B O    1 
ATOM   4099 C  CB   . PRO   B 2 240 ? 5.02748   -42.62433 -34.55375 1.000 29.13512 ? 1292 PRO   B CB   1 
ATOM   4100 C  CG   . PRO   B 2 240 ? 5.02366   -43.60812 -35.67793 1.000 25.32039 ? 1292 PRO   B CG   1 
ATOM   4101 C  CD   . PRO   B 2 240 ? 4.09964   -43.00003 -36.70987 1.000 27.53643 ? 1292 PRO   B CD   1 
ATOM   4102 N  N    . ALA   B 2 241 ? 3.69715   -39.74342 -34.93928 1.000 29.68107 ? 1293 ALA   B N    1 
ATOM   4103 C  CA   . ALA   B 2 241 ? 3.71395   -38.33449 -34.56401 1.000 33.91850 ? 1293 ALA   B CA   1 
ATOM   4104 C  C    . ALA   B 2 241 ? 2.36786   -37.83075 -34.06599 1.000 28.53753 ? 1293 ALA   B C    1 
ATOM   4105 O  O    . ALA   B 2 241 ? 2.32570   -36.75286 -33.46579 1.000 30.93357 ? 1293 ALA   B O    1 
ATOM   4106 C  CB   . ALA   B 2 241 ? 4.17991   -37.47921 -35.74282 1.000 30.85055 ? 1293 ALA   B CB   1 
ATOM   4107 N  N    . LEU   B 2 242 ? 1.27497   -38.56784 -34.28919 1.000 23.82131 ? 1294 LEU   B N    1 
ATOM   4108 C  CA   . LEU   B 2 242 ? -0.04511  -38.13008 -33.85117 1.000 25.20703 ? 1294 LEU   B CA   1 
ATOM   4109 C  C    . LEU   B 2 242 ? -0.36414  -38.52739 -32.41727 1.000 24.81926 ? 1294 LEU   B C    1 
ATOM   4110 O  O    . LEU   B 2 242 ? -1.49219  -38.29161 -31.95928 1.000 25.60490 ? 1294 LEU   B O    1 
ATOM   4111 C  CB   . LEU   B 2 242 ? -1.12799  -38.67804 -34.78434 1.000 23.29192 ? 1294 LEU   B CB   1 
ATOM   4112 C  CG   . LEU   B 2 242 ? -1.13800  -38.02178 -36.16321 1.000 29.46901 ? 1294 LEU   B CG   1 
ATOM   4113 C  CD1  . LEU   B 2 242 ? -2.22787  -38.63774 -37.04939 1.000 26.29862 ? 1294 LEU   B CD1  1 
ATOM   4114 C  CD2  . LEU   B 2 242 ? -1.33219  -36.50883 -36.01794 1.000 33.41216 ? 1294 LEU   B CD2  1 
ATOM   4115 N  N    . ASP   B 2 243 ? 0.59089   -39.11341 -31.70233 1.000 23.82574 ? 1295 ASP   B N    1 
ATOM   4116 C  CA   . ASP   B 2 243 ? 0.33888   -39.59569 -30.35043 1.000 23.07683 ? 1295 ASP   B CA   1 
ATOM   4117 C  C    . ASP   B 2 243 ? -0.01831  -38.43291 -29.42923 1.000 26.66505 ? 1295 ASP   B C    1 
ATOM   4118 O  O    . ASP   B 2 243 ? 0.71256   -37.43784 -29.34400 1.000 28.16050 ? 1295 ASP   B O    1 
ATOM   4119 C  CB   . ASP   B 2 243 ? 1.56994   -40.35164 -29.82351 1.000 25.49768 ? 1295 ASP   B CB   1 
ATOM   4120 C  CG   . ASP   B 2 243 ? 1.37793   -40.89094 -28.40662 1.000 27.77329 ? 1295 ASP   B CG   1 
ATOM   4121 O  OD1  . ASP   B 2 243 ? 0.30298   -41.46512 -28.10679 1.000 25.35730 ? 1295 ASP   B OD1  1 
ATOM   4122 O  OD2  . ASP   B 2 243 ? 2.30687   -40.74698 -27.58854 1.000 31.32972 ? 1295 ASP   B OD2  1 
ATOM   4123 N  N    . GLN   B 2 244 ? -1.14934  -38.56018 -28.73832 1.000 24.90278 ? 1296 GLN   B N    1 
ATOM   4124 C  CA   . GLN   B 2 244 ? -1.59451  -37.55842 -27.77515 1.000 29.19617 ? 1296 GLN   B CA   1 
ATOM   4125 C  C    . GLN   B 2 244 ? -1.89764  -36.21333 -28.43791 1.000 28.59978 ? 1296 GLN   B C    1 
ATOM   4126 O  O    . GLN   B 2 244 ? -1.85380  -35.16444 -27.79471 1.000 27.67736 ? 1296 GLN   B O    1 
ATOM   4127 C  CB   . GLN   B 2 244 ? -0.56459  -37.39550 -26.65706 1.000 28.48813 ? 1296 GLN   B CB   1 
ATOM   4128 C  CG   . GLN   B 2 244 ? -0.26547  -38.71460 -25.94030 1.000 29.05237 ? 1296 GLN   B CG   1 
ATOM   4129 C  CD   . GLN   B 2 244 ? -1.53140  -39.47382 -25.57751 1.000 28.57446 ? 1296 GLN   B CD   1 
ATOM   4130 O  OE1  . GLN   B 2 244 ? -2.34550  -39.01808 -24.76247 1.000 26.36088 ? 1296 GLN   B OE1  1 
ATOM   4131 N  NE2  . GLN   B 2 244 ? -1.71422  -40.63273 -26.19874 1.000 27.70805 ? 1296 GLN   B NE2  1 
ATOM   4132 N  N    . CYS   B 2 245 ? -2.24157  -36.23213 -29.72094 1.000 22.23470 ? 1297 CYS   B N    1 
ATOM   4133 C  CA   . CYS   B 2 245 ? -2.49267  -35.01902 -30.47572 1.000 25.96121 ? 1297 CYS   B CA   1 
ATOM   4134 C  C    . CYS   B 2 245 ? -3.98270  -34.76217 -30.63875 1.000 26.14479 ? 1297 CYS   B C    1 
ATOM   4135 O  O    . CYS   B 2 245 ? -4.79158  -35.68624 -30.75997 1.000 22.95873 ? 1297 CYS   B O    1 
ATOM   4136 C  CB   . CYS   B 2 245 ? -1.86159  -35.09368 -31.86170 1.000 27.07465 ? 1297 CYS   B CB   1 
ATOM   4137 S  SG   . CYS   B 2 245 ? -0.08061  -34.88345 -31.89556 1.000 26.76085 ? 1297 CYS   B SG   1 
ATOM   4138 N  N    . ARG   B 2 246 ? -4.32885  -33.48521 -30.64853 1.000 21.25097 ? 1298 ARG   B N    1 
ATOM   4139 C  CA   . ARG   B 2 246 ? -5.57388  -32.99325 -31.20250 1.000 21.73252 ? 1298 ARG   B CA   1 
ATOM   4140 C  C    . ARG   B 2 246 ? -5.27686  -32.49695 -32.61039 1.000 22.37744 ? 1298 ARG   B C    1 
ATOM   4141 O  O    . ARG   B 2 246 ? -4.16690  -32.04876 -32.89625 1.000 25.63153 ? 1298 ARG   B O    1 
ATOM   4142 C  CB   . ARG   B 2 246 ? -6.14607  -31.87049 -30.33032 1.000 21.77533 ? 1298 ARG   B CB   1 
ATOM   4143 C  CG   . ARG   B 2 246 ? -6.63608  -32.37481 -28.94845 1.000 24.30301 ? 1298 ARG   B CG   1 
ATOM   4144 C  CD   . ARG   B 2 246 ? -8.03700  -32.96596 -29.03063 1.000 23.02449 ? 1298 ARG   B CD   1 
ATOM   4145 N  NE   . ARG   B 2 246 ? -9.01711  -31.93203 -29.33449 1.000 21.20718 ? 1298 ARG   B NE   1 
ATOM   4146 C  CZ   . ARG   B 2 246 ? -10.29407 -32.14413 -29.62760 1.000 25.19011 ? 1298 ARG   B CZ   1 
ATOM   4147 N  NH1  . ARG   B 2 246 ? -10.80592 -33.36418 -29.65286 1.000 24.55632 ? 1298 ARG   B NH1  1 
ATOM   4148 N  NH2  . ARG   B 2 246 ? -11.08018 -31.10017 -29.90045 1.000 21.16464 ? 1298 ARG   B NH2  1 
ATOM   4149 N  N    . VAL   B 2 247 ? -6.25881  -32.59091 -33.49247 1.000 21.85610 ? 1299 VAL   B N    1 
ATOM   4150 C  CA   . VAL   B 2 247 ? -6.03577  -32.25361 -34.89239 1.000 23.74720 ? 1299 VAL   B CA   1 
ATOM   4151 C  C    . VAL   B 2 247 ? -7.14185  -31.34365 -35.40128 1.000 29.57897 ? 1299 VAL   B C    1 
ATOM   4152 O  O    . VAL   B 2 247 ? -8.27588  -31.36088 -34.90734 1.000 27.45943 ? 1299 VAL   B O    1 
ATOM   4153 C  CB   . VAL   B 2 247 ? -5.93657  -33.51543 -35.78462 1.000 27.97259 ? 1299 VAL   B CB   1 
ATOM   4154 C  CG1  . VAL   B 2 247 ? -4.81948  -34.43839 -35.29074 1.000 24.49631 ? 1299 VAL   B CG1  1 
ATOM   4155 C  CG2  . VAL   B 2 247 ? -7.26748  -34.25359 -35.82783 1.000 25.79734 ? 1299 VAL   B CG2  1 
ATOM   4156 N  N    . VAL   B 2 248 ? -6.81189  -30.56042 -36.42311 1.000 29.14794 ? 1300 VAL   B N    1 
ATOM   4157 C  CA   . VAL   B 2 248 ? -7.81394  -29.83840 -37.18803 1.000 25.02745 ? 1300 VAL   B CA   1 
ATOM   4158 C  C    . VAL   B 2 248 ? -7.36686  -29.80907 -38.64300 1.000 28.66236 ? 1300 VAL   B C    1 
ATOM   4159 O  O    . VAL   B 2 248 ? -6.16885  -29.81886 -38.94394 1.000 29.68604 ? 1300 VAL   B O    1 
ATOM   4160 C  CB   . VAL   B 2 248 ? -8.03514  -28.41753 -36.62177 1.000 28.83044 ? 1300 VAL   B CB   1 
ATOM   4161 C  CG1  . VAL   B 2 248 ? -6.74524  -27.64237 -36.65556 1.000 31.13866 ? 1300 VAL   B CG1  1 
ATOM   4162 C  CG2  . VAL   B 2 248 ? -9.12419  -27.69352 -37.39170 1.000 36.57841 ? 1300 VAL   B CG2  1 
ATOM   4163 N  N    . PHE   B 2 249 ? -8.33981  -29.81301 -39.54905 1.000 26.98726 ? 1301 PHE   B N    1 
ATOM   4164 C  CA   . PHE   B 2 249 ? -8.07774  -29.81171 -40.98304 1.000 33.71981 ? 1301 PHE   B CA   1 
ATOM   4165 C  C    . PHE   B 2 249 ? -8.33887  -28.43063 -41.56779 1.000 32.33471 ? 1301 PHE   B C    1 
ATOM   4166 O  O    . PHE   B 2 249 ? -9.20699  -27.69483 -41.09170 1.000 26.33576 ? 1301 PHE   B O    1 
ATOM   4167 C  CB   . PHE   B 2 249 ? -8.96357  -30.84468 -41.69728 1.000 28.29332 ? 1301 PHE   B CB   1 
ATOM   4168 C  CG   . PHE   B 2 249 ? -8.63742  -32.27771 -41.32854 1.000 27.36988 ? 1301 PHE   B CG   1 
ATOM   4169 C  CD1  . PHE   B 2 249 ? -9.12041  -32.83100 -40.14967 1.000 27.76729 ? 1301 PHE   B CD1  1 
ATOM   4170 C  CD2  . PHE   B 2 249 ? -7.84928  -33.05746 -42.15964 1.000 30.52248 ? 1301 PHE   B CD2  1 
ATOM   4171 C  CE1  . PHE   B 2 249 ? -8.82727  -34.13002 -39.80990 1.000 29.27698 ? 1301 PHE   B CE1  1 
ATOM   4172 C  CE2  . PHE   B 2 249 ? -7.53914  -34.36849 -41.82387 1.000 26.86542 ? 1301 PHE   B CE2  1 
ATOM   4173 C  CZ   . PHE   B 2 249 ? -8.02513  -34.90277 -40.64700 1.000 30.56403 ? 1301 PHE   B CZ   1 
ATOM   4174 N  N    . ASN   B 2 250 ? -7.57886  -28.07834 -42.60668 1.000 29.71726 ? 1302 ASN   B N    1 
ATOM   4175 C  CA   . ASN   B 2 250 ? -7.98595  -26.94724 -43.42249 1.000 34.40935 ? 1302 ASN   B CA   1 
ATOM   4176 C  C    . ASN   B 2 250 ? -9.33588  -27.25928 -44.06763 1.000 35.81187 ? 1302 ASN   B C    1 
ATOM   4177 O  O    . ASN   B 2 250 ? -9.83375  -28.38935 -44.02487 1.000 38.17549 ? 1302 ASN   B O    1 
ATOM   4178 C  CB   . ASN   B 2 250 ? -6.91894  -26.60691 -44.46937 1.000 31.88071 ? 1302 ASN   B CB   1 
ATOM   4179 C  CG   . ASN   B 2 250 ? -6.71975  -27.70869 -45.50557 1.000 35.83282 ? 1302 ASN   B CG   1 
ATOM   4180 O  OD1  . ASN   B 2 250 ? -7.49663  -28.65577 -45.58879 1.000 40.30447 ? 1302 ASN   B OD1  1 
ATOM   4181 N  ND2  . ASN   B 2 250 ? -5.67172  -27.57041 -46.31349 1.000 39.26987 ? 1302 ASN   B ND2  1 
ATOM   4182 N  N    . HIS   B 2 251 ? -9.94597  -26.23624 -44.66147 1.000 35.99061 ? 1303 HIS   B N    1 
ATOM   4183 C  CA   . HIS   B 2 251 ? -11.33093 -26.37733 -45.09057 1.000 41.35775 ? 1303 HIS   B CA   1 
ATOM   4184 C  C    . HIS   B 2 251 ? -11.47177 -27.13810 -46.39872 1.000 39.58128 ? 1303 HIS   B C    1 
ATOM   4185 O  O    . HIS   B 2 251 ? -12.56969 -27.60418 -46.71187 1.000 41.44094 ? 1303 HIS   B O    1 
ATOM   4186 C  CB   . HIS   B 2 251 ? -11.99010 -24.99840 -45.17334 1.000 36.74874 ? 1303 HIS   B CB   1 
ATOM   4187 C  CG   . HIS   B 2 251 ? -12.15825 -24.35467 -43.83023 1.000 42.74112 ? 1303 HIS   B CG   1 
ATOM   4188 N  ND1  . HIS   B 2 251 ? -11.10435 -23.79767 -43.13607 1.000 44.13312 ? 1303 HIS   B ND1  1 
ATOM   4189 C  CD2  . HIS   B 2 251 ? -13.23931 -24.23395 -43.02527 1.000 41.47429 ? 1303 HIS   B CD2  1 
ATOM   4190 C  CE1  . HIS   B 2 251 ? -11.53347 -23.33795 -41.97400 1.000 39.11624 ? 1303 HIS   B CE1  1 
ATOM   4191 N  NE2  . HIS   B 2 251 ? -12.82745 -23.58812 -41.88312 1.000 44.48579 ? 1303 HIS   B NE2  1 
ATOM   4192 N  N    . THR   B 2 252 ? -10.38771 -27.30683 -47.14869 1.000 38.71260 ? 1304 THR   B N    1 
ATOM   4193 C  CA   . THR   B 2 252 ? -10.44154 -28.20162 -48.29686 1.000 42.85997 ? 1304 THR   B CA   1 
ATOM   4194 C  C    . THR   B 2 252 ? -10.20638 -29.66166 -47.92113 1.000 45.29489 ? 1304 THR   B C    1 
ATOM   4195 O  O    . THR   B 2 252 ? -10.46223 -30.54154 -48.74431 1.000 43.96981 ? 1304 THR   B O    1 
ATOM   4196 C  CB   . THR   B 2 252 ? -9.41553  -27.77729 -49.34973 1.000 36.19980 ? 1304 THR   B CB   1 
ATOM   4197 O  OG1  . THR   B 2 252 ? -8.10957  -27.72025 -48.75665 1.000 43.48816 ? 1304 THR   B OG1  1 
ATOM   4198 C  CG2  . THR   B 2 252 ? -9.78166  -26.41823 -49.93049 1.000 40.05867 ? 1304 THR   B CG2  1 
ATOM   4199 N  N    . GLY   B 2 253 ? -9.72241  -29.93783 -46.71315 1.000 42.42921 ? 1305 GLY   B N    1 
ATOM   4200 C  CA   . GLY   B 2 253 ? -9.44427  -31.30287 -46.32040 1.000 35.75812 ? 1305 GLY   B CA   1 
ATOM   4201 C  C    . GLY   B 2 253 ? -8.13517  -31.85361 -46.82843 1.000 38.35286 ? 1305 GLY   B C    1 
ATOM   4202 O  O    . GLY   B 2 253 ? -7.97202  -33.07458 -46.88465 1.000 40.81506 ? 1305 GLY   B O    1 
ATOM   4203 N  N    . THR   B 2 254 ? -7.18526  -30.99243 -47.19521 1.000 34.03387 ? 1306 THR   B N    1 
ATOM   4204 C  CA   . THR   B 2 254 ? -5.91717  -31.44917 -47.74723 1.000 35.56799 ? 1306 THR   B CA   1 
ATOM   4205 C  C    . THR   B 2 254 ? -4.76423  -31.37122 -46.76515 1.000 31.32643 ? 1306 THR   B C    1 
ATOM   4206 O  O    . THR   B 2 254 ? -3.72414  -31.99204 -47.00322 1.000 33.20771 ? 1306 THR   B O    1 
ATOM   4207 C  CB   . THR   B 2 254 ? -5.54020  -30.63289 -48.98706 1.000 40.60428 ? 1306 THR   B CB   1 
ATOM   4208 O  OG1  . THR   B 2 254 ? -5.50939  -29.23895 -48.65179 1.000 39.82215 ? 1306 THR   B OG1  1 
ATOM   4209 C  CG2  . THR   B 2 254 ? -6.53011  -30.88380 -50.09916 1.000 38.39349 ? 1306 THR   B CG2  1 
ATOM   4210 N  N    . VAL   B 2 255 ? -4.90938  -30.61844 -45.68602 1.000 31.46277 ? 1307 VAL   B N    1 
ATOM   4211 C  CA   . VAL   B 2 255 ? -3.85945  -30.48650 -44.69294 1.000 28.72091 ? 1307 VAL   B CA   1 
ATOM   4212 C  C    . VAL   B 2 255 ? -4.46050  -30.70683 -43.31601 1.000 30.10499 ? 1307 VAL   B C    1 
ATOM   4213 O  O    . VAL   B 2 255 ? -5.60156  -30.31202 -43.05300 1.000 31.33621 ? 1307 VAL   B O    1 
ATOM   4214 C  CB   . VAL   B 2 255 ? -3.17362  -29.11440 -44.77564 1.000 34.18144 ? 1307 VAL   B CB   1 
ATOM   4215 C  CG1  . VAL   B 2 255 ? -2.14769  -28.98548 -43.66056 1.000 35.29963 ? 1307 VAL   B CG1  1 
ATOM   4216 C  CG2  . VAL   B 2 255 ? -2.52256  -28.95506 -46.13758 1.000 36.91756 ? 1307 VAL   B CG2  1 
ATOM   4217 N  N    . MET   B 2 256 ? -3.69247  -31.35590 -42.44909 1.000 28.57585 ? 1308 MET   B N    1 
ATOM   4218 C  CA   . MET   B 2 256 ? -4.08851  -31.63521 -41.07817 1.000 31.21803 ? 1308 MET   B CA   1 
ATOM   4219 C  C    . MET   B 2 256 ? -3.06364  -31.00326 -40.14899 1.000 30.50351 ? 1308 MET   B C    1 
ATOM   4220 O  O    . MET   B 2 256 ? -1.85960  -31.24508 -40.29597 1.000 31.70381 ? 1308 MET   B O    1 
ATOM   4221 C  CB   . MET   B 2 256 ? -4.17734  -33.14627 -40.82146 1.000 31.20797 ? 1308 MET   B CB   1 
ATOM   4222 C  CG   . MET   B 2 256 ? -4.86737  -33.49560 -39.50956 1.000 32.29089 ? 1308 MET   B CG   1 
ATOM   4223 S  SD   . MET   B 2 256 ? -4.86117  -35.27068 -39.09290 1.000 33.60267 ? 1308 MET   B SD   1 
ATOM   4224 C  CE   . MET   B 2 256 ? -3.10113  -35.60546 -39.08386 1.000 31.51344 ? 1308 MET   B CE   1 
ATOM   4225 N  N    . TYR   B 2 257 ? -3.53479  -30.18349 -39.21086 1.000 30.13310 ? 1309 TYR   B N    1 
ATOM   4226 C  CA   . TYR   B 2 257 ? -2.68391  -29.66859 -38.14272 1.000 32.17310 ? 1309 TYR   B CA   1 
ATOM   4227 C  C    . TYR   B 2 257 ? -2.80086  -30.57283 -36.92690 1.000 32.54585 ? 1309 TYR   B C    1 
ATOM   4228 O  O    . TYR   B 2 257 ? -3.89583  -31.01903 -36.58104 1.000 30.22619 ? 1309 TYR   B O    1 
ATOM   4229 C  CB   . TYR   B 2 257 ? -3.08210  -28.24571 -37.75047 1.000 33.52227 ? 1309 TYR   B CB   1 
ATOM   4230 C  CG   . TYR   B 2 257 ? -2.95517  -27.24249 -38.86528 1.000 32.65558 ? 1309 TYR   B CG   1 
ATOM   4231 C  CD1  . TYR   B 2 257 ? -3.88311  -27.19941 -39.89632 1.000 33.77974 ? 1309 TYR   B CD1  1 
ATOM   4232 C  CD2  . TYR   B 2 257 ? -1.90628  -26.33136 -38.88305 1.000 36.09329 ? 1309 TYR   B CD2  1 
ATOM   4233 C  CE1  . TYR   B 2 257 ? -3.76717  -26.27320 -40.91414 1.000 36.40874 ? 1309 TYR   B CE1  1 
ATOM   4234 C  CE2  . TYR   B 2 257 ? -1.77933  -25.41015 -39.89487 1.000 36.20673 ? 1309 TYR   B CE2  1 
ATOM   4235 C  CZ   . TYR   B 2 257 ? -2.70628  -25.38607 -40.90491 1.000 36.95465 ? 1309 TYR   B CZ   1 
ATOM   4236 O  OH   . TYR   B 2 257 ? -2.57534  -24.46786 -41.91473 1.000 39.25566 ? 1309 TYR   B OH   1 
ATOM   4237 N  N    . GLY   B 2 258 ? -1.67287  -30.83882 -36.28189 1.000 27.17891 ? 1310 GLY   B N    1 
ATOM   4238 C  CA   . GLY   B 2 258 ? -1.68984  -31.63005 -35.07204 1.000 26.48145 ? 1310 GLY   B CA   1 
ATOM   4239 C  C    . GLY   B 2 258 ? -0.76096  -31.06313 -34.02588 1.000 31.30776 ? 1310 GLY   B C    1 
ATOM   4240 O  O    . GLY   B 2 258 ? 0.34800   -30.62194 -34.34773 1.000 35.58374 ? 1310 GLY   B O    1 
ATOM   4241 N  N    . ALA   B 2 259 ? -1.20303  -31.03542 -32.77390 1.000 28.00875 ? 1311 ALA   B N    1 
ATOM   4242 C  CA   . ALA   B 2 259 ? -0.35615  -30.57753 -31.67976 1.000 31.76583 ? 1311 ALA   B CA   1 
ATOM   4243 C  C    . ALA   B 2 259 ? -0.51510  -31.53677 -30.51395 1.000 29.12443 ? 1311 ALA   B C    1 
ATOM   4244 O  O    . ALA   B 2 259 ? -1.62105  -32.00896 -30.23610 1.000 23.05840 ? 1311 ALA   B O    1 
ATOM   4245 C  CB   . ALA   B 2 259 ? -0.70635  -29.15065 -31.24451 1.000 30.51790 ? 1311 ALA   B CB   1 
ATOM   4246 N  N    . MET   B 2 260 ? 0.58990   -31.82876 -29.84395 1.000 25.86330 ? 1312 MET   B N    1 
ATOM   4247 C  CA   . MET   B 2 260 ? 0.60997   -32.82896 -28.79114 1.000 26.24601 ? 1312 MET   B CA   1 
ATOM   4248 C  C    . MET   B 2 260 ? 0.20182   -32.22926 -27.45205 1.000 27.67311 ? 1312 MET   B C    1 
ATOM   4249 O  O    . MET   B 2 260 ? 0.74467   -31.20327 -27.02982 1.000 27.35123 ? 1312 MET   B O    1 
ATOM   4250 C  CB   . MET   B 2 260 ? 1.99904   -33.44781 -28.67718 1.000 22.41012 ? 1312 MET   B CB   1 
ATOM   4251 C  CG   . MET   B 2 260 ? 2.09610   -34.43501 -27.53336 1.000 29.70005 ? 1312 MET   B CG   1 
ATOM   4252 S  SD   . MET   B 2 260 ? 3.68820   -35.28583 -27.49743 1.000 34.18078 ? 1312 MET   B SD   1 
ATOM   4253 C  CE   . MET   B 2 260 ? 3.12939   -36.96495 -27.20478 1.000 37.05328 ? 1312 MET   B CE   1 
ATOM   4254 N  N    . LEU   B 2 261 ? -0.75814  -32.87250 -26.79022 1.000 26.65648 ? 1313 LEU   B N    1 
ATOM   4255 C  CA   . LEU   B 2 261 ? -1.06525  -32.52680 -25.41217 1.000 27.56804 ? 1313 LEU   B CA   1 
ATOM   4256 C  C    . LEU   B 2 261 ? 0.17972   -32.66281 -24.54013 1.000 32.16160 ? 1313 LEU   B C    1 
ATOM   4257 O  O    . LEU   B 2 261 ? 1.04883   -33.50866 -24.78224 1.000 31.92206 ? 1313 LEU   B O    1 
ATOM   4258 C  CB   . LEU   B 2 261 ? -2.17817  -33.42503 -24.88240 1.000 26.41047 ? 1313 LEU   B CB   1 
ATOM   4259 C  CG   . LEU   B 2 261 ? -3.52316  -33.19107 -25.56643 1.000 29.77987 ? 1313 LEU   B CG   1 
ATOM   4260 C  CD1  . LEU   B 2 261 ? -4.49304  -34.33124 -25.29670 1.000 27.90055 ? 1313 LEU   B CD1  1 
ATOM   4261 C  CD2  . LEU   B 2 261 ? -4.11335  -31.85623 -25.11621 1.000 26.55398 ? 1313 LEU   B CD2  1 
ATOM   4262 N  N    . GLN   B 2 262 ? 0.27056   -31.81099 -23.51896 1.000 33.24004 ? 1314 GLN   B N    1 
ATOM   4263 C  CA   . GLN   B 2 262 ? 1.27452   -32.00207 -22.47794 1.000 40.27861 ? 1314 GLN   B CA   1 
ATOM   4264 C  C    . GLN   B 2 262 ? 0.81561   -33.11730 -21.55018 1.000 43.87294 ? 1314 GLN   B C    1 
ATOM   4265 O  O    . GLN   B 2 262 ? -0.32242  -33.10553 -21.07224 1.000 50.29940 ? 1314 GLN   B O    1 
ATOM   4266 C  CB   . GLN   B 2 262 ? 1.49632   -30.71619 -21.68669 1.000 42.47835 ? 1314 GLN   B CB   1 
ATOM   4267 C  CG   . GLN   B 2 262 ? 2.34024   -29.69795 -22.41145 1.000 43.21324 ? 1314 GLN   B CG   1 
ATOM   4268 C  CD   . GLN   B 2 262 ? 3.02707   -28.74105 -21.45423 1.000 52.46945 ? 1314 GLN   B CD   1 
ATOM   4269 O  OE1  . GLN   B 2 262 ? 4.25606   -28.69891 -21.37916 1.000 56.42985 ? 1314 GLN   B OE1  1 
ATOM   4270 N  NE2  . GLN   B 2 262 ? 2.23394   -27.96828 -20.71513 1.000 54.07305 ? 1314 GLN   B NE2  1 
ATOM   4271 N  N    . ALA   B 2 263 ? 1.69771   -34.08424 -21.30032 1.000 58.62423 ? 1315 ALA   B N    1 
ATOM   4272 C  CA   . ALA   B 2 263 ? 1.30383   -35.32241 -20.63057 1.000 59.12448 ? 1315 ALA   B CA   1 
ATOM   4273 C  C    . ALA   B 2 263 ? 1.01672   -35.12173 -19.14755 1.000 69.60947 ? 1315 ALA   B C    1 
ATOM   4274 O  O    . ALA   B 2 263 ? 0.34658   -34.15888 -18.75640 1.000 74.57352 ? 1315 ALA   B O    1 
ATOM   4275 C  CB   . ALA   B 2 263 ? 2.38997   -36.38525 -20.80471 1.000 59.73767 ? 1315 ALA   B CB   1 
ATOM   4276 N  N    . ASP   B 2 264 ? 1.50079   -36.03983 -18.32070 1.000 76.92041 ? 1316 ASP   B N    1 
ATOM   4277 C  CA   . ASP   B 2 264 ? 1.38070   -35.92311 -16.87468 1.000 80.90007 ? 1316 ASP   B CA   1 
ATOM   4278 C  C    . ASP   B 2 264 ? 2.75269   -36.11707 -16.24664 1.000 81.44048 ? 1316 ASP   B C    1 
ATOM   4279 O  O    . ASP   B 2 264 ? 3.72076   -36.41481 -16.94865 1.000 77.42827 ? 1316 ASP   B O    1 
ATOM   4280 C  CB   . ASP   B 2 264 ? 0.37979   -36.94434 -16.31993 1.000 78.95102 ? 1316 ASP   B CB   1 
ATOM   4281 C  CG   . ASP   B 2 264 ? 0.80498   -38.38224 -16.57318 1.000 89.44244 ? 1316 ASP   B CG   1 
ATOM   4282 O  OD1  . ASP   B 2 264 ? 1.64900   -38.90428 -15.81123 1.000 93.26334 ? 1316 ASP   B OD1  1 
ATOM   4283 O  OD2  . ASP   B 2 264 ? 0.28711   -38.99512 -17.53132 1.000 83.06351 ? 1316 ASP   B OD2  1 
ATOM   4284 N  N    . LYS   B 2 275 ? -1.07458  -25.85958 -15.96691 1.000 46.39995 ? 1327 LYS   B N    1 
ATOM   4285 C  CA   . LYS   B 2 275 ? -0.20647  -26.22427 -17.08793 1.000 49.68660 ? 1327 LYS   B CA   1 
ATOM   4286 C  C    . LYS   B 2 275 ? -0.88342  -26.06909 -18.46994 1.000 39.94614 ? 1327 LYS   B C    1 
ATOM   4287 O  O    . LYS   B 2 275 ? -2.08238  -26.30821 -18.60905 1.000 38.89512 ? 1327 LYS   B O    1 
ATOM   4288 C  CB   . LYS   B 2 275 ? 0.28669   -27.65624 -16.91018 1.000 48.42133 ? 1327 LYS   B CB   1 
ATOM   4289 C  CG   . LYS   B 2 275 ? 1.48378   -27.97893 -17.76417 1.000 57.73539 ? 1327 LYS   B CG   1 
ATOM   4290 C  CD   . LYS   B 2 275 ? 2.26089   -29.16194 -17.21635 1.000 66.48220 ? 1327 LYS   B CD   1 
ATOM   4291 C  CE   . LYS   B 2 275 ? 1.65108   -30.49594 -17.62764 1.000 65.29009 ? 1327 LYS   B CE   1 
ATOM   4292 N  NZ   . LYS   B 2 275 ? 2.70221   -31.55980 -17.66978 1.000 69.31569 ? 1327 LYS   B NZ   1 
ATOM   4293 N  N    . SER   B 2 276 ? -0.10541  -25.67380 -19.48482 1.000 39.97589 ? 1328 SER   B N    1 
ATOM   4294 C  CA   . SER   B 2 276 ? -0.65336  -25.46062 -20.82181 1.000 38.79404 ? 1328 SER   B CA   1 
ATOM   4295 C  C    . SER   B 2 276 ? -1.26818  -26.74859 -21.37309 1.000 31.15231 ? 1328 SER   B C    1 
ATOM   4296 O  O    . SER   B 2 276 ? -0.75306  -27.84057 -21.13327 1.000 31.60533 ? 1328 SER   B O    1 
ATOM   4297 C  CB   . SER   B 2 276 ? 0.43163   -24.97730 -21.78166 1.000 29.69417 ? 1328 SER   B CB   1 
ATOM   4298 O  OG   . SER   B 2 276 ? 0.72845   -23.61031 -21.56939 1.000 46.43924 ? 1328 SER   B OG   1 
ATOM   4299 N  N    . PRO   B 2 277 ? -2.35015  -26.64857 -22.14313 1.000 28.42971 ? 1329 PRO   B N    1 
ATOM   4300 C  CA   . PRO   B 2 277 ? -2.89996  -27.87152 -22.75339 1.000 25.86878 ? 1329 PRO   B CA   1 
ATOM   4301 C  C    . PRO   B 2 277 ? -1.93883  -28.52822 -23.72646 1.000 28.97486 ? 1329 PRO   B C    1 
ATOM   4302 O  O    . PRO   B 2 277 ? -1.81268  -29.75721 -23.72769 1.000 28.13547 ? 1329 PRO   B O    1 
ATOM   4303 C  CB   . PRO   B 2 277 ? -4.18399  -27.39055 -23.44537 1.000 31.27305 ? 1329 PRO   B CB   1 
ATOM   4304 C  CG   . PRO   B 2 277 ? -4.08816  -25.91153 -23.51209 1.000 30.67789 ? 1329 PRO   B CG   1 
ATOM   4305 C  CD   . PRO   B 2 277 ? -3.17828  -25.46162 -22.40895 1.000 28.52237 ? 1329 PRO   B CD   1 
ATOM   4306 N  N    . PHE   B 2 278 ? -1.23188  -27.75198 -24.54028 1.000 24.71031 ? 1330 PHE   B N    1 
ATOM   4307 C  CA   . PHE   B 2 278 ? -0.35376  -28.32369 -25.54834 1.000 22.28609 ? 1330 PHE   B CA   1 
ATOM   4308 C  C    . PHE   B 2 278 ? 1.10218   -27.95156 -25.27919 1.000 31.66266 ? 1330 PHE   B C    1 
ATOM   4309 O  O    . PHE   B 2 278 ? 1.41303   -27.09668 -24.44701 1.000 30.84753 ? 1330 PHE   B O    1 
ATOM   4310 C  CB   . PHE   B 2 278 ? -0.77874  -27.87147 -26.95128 1.000 24.63531 ? 1330 PHE   B CB   1 
ATOM   4311 C  CG   . PHE   B 2 278 ? -2.17067  -28.29057 -27.31343 1.000 28.28320 ? 1330 PHE   B CG   1 
ATOM   4312 C  CD1  . PHE   B 2 278 ? -2.41448  -29.54550 -27.86768 1.000 24.28476 ? 1330 PHE   B CD1  1 
ATOM   4313 C  CD2  . PHE   B 2 278 ? -3.24678  -27.45075 -27.07233 1.000 22.05938 ? 1330 PHE   B CD2  1 
ATOM   4314 C  CE1  . PHE   B 2 278 ? -3.71142  -29.94660 -28.18483 1.000 24.70494 ? 1330 PHE   B CE1  1 
ATOM   4315 C  CE2  . PHE   B 2 278 ? -4.54372  -27.83685 -27.38747 1.000 24.24794 ? 1330 PHE   B CE2  1 
ATOM   4316 C  CZ   . PHE   B 2 278 ? -4.78253  -29.09177 -27.94072 1.000 22.19608 ? 1330 PHE   B CZ   1 
ATOM   4317 N  N    . GLY   B 2 279 ? 1.99730   -28.63632 -25.98827 1.000 29.08716 ? 1331 GLY   B N    1 
ATOM   4318 C  CA   . GLY   B 2 279 ? 3.40126   -28.27714 -26.02013 1.000 33.37628 ? 1331 GLY   B CA   1 
ATOM   4319 C  C    . GLY   B 2 279 ? 3.64516   -27.06894 -26.90588 1.000 35.53996 ? 1331 GLY   B C    1 
ATOM   4320 O  O    . GLY   B 2 279 ? 2.72410   -26.33998 -27.28180 1.000 28.34334 ? 1331 GLY   B O    1 
ATOM   4321 N  N    . SER   B 2 280 ? 4.91516   -26.86072 -27.25178 1.000 34.74777 ? 1332 SER   B N    1 
ATOM   4322 C  CA   . SER   B 2 280 ? 5.31605   -25.64854 -27.95552 1.000 33.10598 ? 1332 SER   B CA   1 
ATOM   4323 C  C    . SER   B 2 280 ? 5.37115   -25.81625 -29.46455 1.000 36.95946 ? 1332 SER   B C    1 
ATOM   4324 O  O    . SER   B 2 280 ? 5.73807   -24.86607 -30.16235 1.000 37.28571 ? 1332 SER   B O    1 
ATOM   4325 C  CB   . SER   B 2 280 ? 6.67496   -25.15647 -27.44236 1.000 35.90037 ? 1332 SER   B CB   1 
ATOM   4326 O  OG   . SER   B 2 280 ? 7.66309   -26.16433 -27.57749 1.000 40.10340 ? 1332 SER   B OG   1 
ATOM   4327 N  N    . SER   B 2 281 ? 4.99132   -26.98020 -29.98779 1.000 28.33166 ? 1333 SER   B N    1 
ATOM   4328 C  CA   . SER   B 2 281 ? 5.06643   -27.23392 -31.41584 1.000 28.76406 ? 1333 SER   B CA   1 
ATOM   4329 C  C    . SER   B 2 281 ? 3.74652   -27.78098 -31.93901 1.000 34.15786 ? 1333 SER   B C    1 
ATOM   4330 O  O    . SER   B 2 281 ? 2.99156   -28.43621 -31.21618 1.000 34.20503 ? 1333 SER   B O    1 
ATOM   4331 C  CB   . SER   B 2 281 ? 6.18857   -28.22972 -31.73997 1.000 37.85823 ? 1333 SER   B CB   1 
ATOM   4332 O  OG   . SER   B 2 281 ? 5.92669   -29.47287 -31.11121 1.000 44.59958 ? 1333 SER   B OG   1 
ATOM   4333 N  N    . PHE   B 2 282 ? 3.47856   -27.50577 -33.21198 1.000 32.68158 ? 1334 PHE   B N    1 
ATOM   4334 C  CA   . PHE   B 2 282 ? 2.44969   -28.21976 -33.94817 1.000 35.32261 ? 1334 PHE   B CA   1 
ATOM   4335 C  C    . PHE   B 2 282 ? 3.05381   -28.68044 -35.26222 1.000 38.93877 ? 1334 PHE   B C    1 
ATOM   4336 O  O    . PHE   B 2 282 ? 4.14078   -28.24823 -35.65108 1.000 40.03961 ? 1334 PHE   B O    1 
ATOM   4337 C  CB   . PHE   B 2 282 ? 1.19259   -27.36187 -34.17707 1.000 31.07079 ? 1334 PHE   B CB   1 
ATOM   4338 C  CG   . PHE   B 2 282 ? 1.42149   -26.14368 -35.02683 1.000 36.83897 ? 1334 PHE   B CG   1 
ATOM   4339 C  CD1  . PHE   B 2 282 ? 1.79031   -24.94274 -34.45358 1.000 38.10907 ? 1334 PHE   B CD1  1 
ATOM   4340 C  CD2  . PHE   B 2 282 ? 1.24757   -26.19844 -36.40785 1.000 39.85071 ? 1334 PHE   B CD2  1 
ATOM   4341 C  CE1  . PHE   B 2 282 ? 2.00122   -23.82357 -35.23336 1.000 35.21412 ? 1334 PHE   B CE1  1 
ATOM   4342 C  CE2  . PHE   B 2 282 ? 1.45248   -25.07326 -37.19763 1.000 39.24778 ? 1334 PHE   B CE2  1 
ATOM   4343 C  CZ   . PHE   B 2 282 ? 1.83130   -23.88633 -36.60738 1.000 38.67468 ? 1334 PHE   B CZ   1 
ATOM   4344 N  N    . ARG   B 2 283 ? 2.33996   -29.56539 -35.95243 1.000 30.45998 ? 1335 ARG   B N    1 
ATOM   4345 C  CA   . ARG   B 2 283 ? 2.83710   -30.15910 -37.18351 1.000 37.05337 ? 1335 ARG   B CA   1 
ATOM   4346 C  C    . ARG   B 2 283 ? 1.72016   -30.21804 -38.21058 1.000 37.33109 ? 1335 ARG   B C    1 
ATOM   4347 O  O    . ARG   B 2 283 ? 0.55117   -30.42425 -37.86469 1.000 31.83761 ? 1335 ARG   B O    1 
ATOM   4348 C  CB   . ARG   B 2 283 ? 3.40226   -31.56608 -36.92475 1.000 37.43856 ? 1335 ARG   B CB   1 
ATOM   4349 C  CG   . ARG   B 2 283 ? 4.43320   -31.58016 -35.81169 1.000 47.49217 ? 1335 ARG   B CG   1 
ATOM   4350 C  CD   . ARG   B 2 283 ? 4.95535   -32.97116 -35.50193 1.000 53.09140 ? 1335 ARG   B CD   1 
ATOM   4351 N  NE   . ARG   B 2 283 ? 5.42150   -33.65788 -36.69803 1.000 55.96850 ? 1335 ARG   B NE   1 
ATOM   4352 C  CZ   . ARG   B 2 283 ? 6.35461   -34.59876 -36.69816 1.000 60.29085 ? 1335 ARG   B CZ   1 
ATOM   4353 N  NH1  . ARG   B 2 283 ? 6.98460   -34.94790 -35.58519 1.000 61.49809 ? 1335 ARG   B NH1  1 
ATOM   4354 N  NH2  . ARG   B 2 283 ? 6.66475   -35.20451 -37.84426 1.000 56.59617 ? 1335 ARG   B NH2  1 
ATOM   4355 N  N    . THR   B 2 284 ? 2.08221   -30.01876 -39.47053 1.000 30.76232 ? 1336 THR   B N    1 
ATOM   4356 C  CA   . THR   B 2 284 ? 1.14629   -30.21267 -40.56061 1.000 28.77598 ? 1336 THR   B CA   1 
ATOM   4357 C  C    . THR   B 2 284 ? 1.44049   -31.53350 -41.26185 1.000 32.49512 ? 1336 THR   B C    1 
ATOM   4358 O  O    . THR   B 2 284 ? 2.58355   -31.99935 -41.30787 1.000 32.44790 ? 1336 THR   B O    1 
ATOM   4359 C  CB   . THR   B 2 284 ? 1.21920   -29.06047 -41.55539 1.000 37.08057 ? 1336 THR   B CB   1 
ATOM   4360 O  OG1  . THR   B 2 284 ? 2.57521   -28.91022 -41.99329 1.000 39.92407 ? 1336 THR   B OG1  1 
ATOM   4361 C  CG2  . THR   B 2 284 ? 0.76001   -27.76965 -40.89217 1.000 36.34390 ? 1336 THR   B CG2  1 
ATOM   4362 N  N    . PHE   B 2 285 ? 0.39059   -32.13552 -41.80402 1.000 29.48785 ? 1337 PHE   B N    1 
ATOM   4363 C  CA   . PHE   B 2 285 ? 0.47978   -33.41038 -42.48925 1.000 34.26064 ? 1337 PHE   B CA   1 
ATOM   4364 C  C    . PHE   B 2 285 ? -0.32816  -33.34024 -43.76929 1.000 36.47126 ? 1337 PHE   B C    1 
ATOM   4365 O  O    . PHE   B 2 285 ? -1.38723  -32.70536 -43.81822 1.000 35.59517 ? 1337 PHE   B O    1 
ATOM   4366 C  CB   . PHE   B 2 285 ? -0.07512  -34.56261 -41.65150 1.000 30.75560 ? 1337 PHE   B CB   1 
ATOM   4367 C  CG   . PHE   B 2 285 ? 0.58083   -34.73078 -40.32850 1.000 30.30353 ? 1337 PHE   B CG   1 
ATOM   4368 C  CD1  . PHE   B 2 285 ? 0.21267   -33.94403 -39.25637 1.000 31.98742 ? 1337 PHE   B CD1  1 
ATOM   4369 C  CD2  . PHE   B 2 285 ? 1.53894   -35.70670 -40.14363 1.000 34.25992 ? 1337 PHE   B CD2  1 
ATOM   4370 C  CE1  . PHE   B 2 285 ? 0.81263   -34.10819 -38.02937 1.000 33.97491 ? 1337 PHE   B CE1  1 
ATOM   4371 C  CE2  . PHE   B 2 285 ? 2.13989   -35.88086 -38.91463 1.000 33.13383 ? 1337 PHE   B CE2  1 
ATOM   4372 C  CZ   . PHE   B 2 285 ? 1.77774   -35.08210 -37.85950 1.000 37.18215 ? 1337 PHE   B CZ   1 
ATOM   4373 N  N    . ASN   B 2 286 ? 0.15398   -34.03199 -44.79339 1.000 34.42839 ? 1338 ASN   B N    1 
ATOM   4374 C  CA   . ASN   B 2 286 ? -0.68292  -34.30487 -45.94949 1.000 33.92821 ? 1338 ASN   B CA   1 
ATOM   4375 C  C    . ASN   B 2 286 ? -1.90785  -35.10411 -45.50470 1.000 33.64671 ? 1338 ASN   B C    1 
ATOM   4376 O  O    . ASN   B 2 286 ? -1.77775  -36.18320 -44.91690 1.000 33.02743 ? 1338 ASN   B O    1 
ATOM   4377 C  CB   . ASN   B 2 286 ? 0.12623   -35.06457 -47.00459 1.000 36.46366 ? 1338 ASN   B CB   1 
ATOM   4378 C  CG   . ASN   B 2 286 ? -0.59568  -35.18041 -48.32865 1.000 39.81478 ? 1338 ASN   B CG   1 
ATOM   4379 O  OD1  . ASN   B 2 286 ? -1.79164  -35.47555 -48.38477 1.000 43.04595 ? 1338 ASN   B OD1  1 
ATOM   4380 N  ND2  . ASN   B 2 286 ? 0.13235   -34.95012 -49.41556 1.000 49.87705 ? 1338 ASN   B ND2  1 
ATOM   4381 N  N    . ALA   B 2 287 ? -3.10190  -34.56920 -45.76967 1.000 28.66434 ? 1339 ALA   B N    1 
ATOM   4382 C  CA   . ALA   B 2 287 ? -4.31884  -35.21544 -45.28186 1.000 39.98257 ? 1339 ALA   B CA   1 
ATOM   4383 C  C    . ALA   B 2 287 ? -4.66865  -36.49634 -46.03512 1.000 39.64633 ? 1339 ALA   B C    1 
ATOM   4384 O  O    . ALA   B 2 287 ? -5.52658  -37.25053 -45.56931 1.000 37.06166 ? 1339 ALA   B O    1 
ATOM   4385 C  CB   . ALA   B 2 287 ? -5.49596  -34.24257 -45.34774 1.000 35.29326 ? 1339 ALA   B CB   1 
ATOM   4386 N  N    . THR   B 2 288 ? -4.03455  -36.76605 -47.17513 1.000 34.02874 ? 1340 THR   B N    1 
ATOM   4387 C  CA   . THR   B 2 288 ? -4.31636  -37.97894 -47.93538 1.000 34.56118 ? 1340 THR   B CA   1 
ATOM   4388 C  C    . THR   B 2 288 ? -3.46124  -39.16092 -47.49256 1.000 36.08580 ? 1340 THR   B C    1 
ATOM   4389 O  O    . THR   B 2 288 ? -3.97112  -40.27701 -47.35079 1.000 41.57528 ? 1340 THR   B O    1 
ATOM   4390 C  CB   . THR   B 2 288 ? -4.09331  -37.73663 -49.43032 1.000 39.18176 ? 1340 THR   B CB   1 
ATOM   4391 O  OG1  . THR   B 2 288 ? -4.95941  -36.69565 -49.88217 1.000 38.05013 ? 1340 THR   B OG1  1 
ATOM   4392 C  CG2  . THR   B 2 288 ? -4.40012  -38.99252 -50.20257 1.000 40.64307 ? 1340 THR   B CG2  1 
ATOM   4393 N  N    . ASP   B 2 289 ? -2.16728  -38.94580 -47.27044 1.000 33.44846 ? 1341 ASP   B N    1 
ATOM   4394 C  CA   . ASP   B 2 289 ? -1.24917  -40.02675 -46.94860 1.000 35.18288 ? 1341 ASP   B CA   1 
ATOM   4395 C  C    . ASP   B 2 289 ? -0.57126  -39.83292 -45.60053 1.000 38.30916 ? 1341 ASP   B C    1 
ATOM   4396 O  O    . ASP   B 2 289 ? 0.30981   -40.62088 -45.24463 1.000 35.94909 ? 1341 ASP   B O    1 
ATOM   4397 C  CB   . ASP   B 2 289 ? -0.19409  -40.16641 -48.05657 1.000 44.08276 ? 1341 ASP   B CB   1 
ATOM   4398 C  CG   . ASP   B 2 289 ? 0.59777   -38.88928 -48.27728 1.000 44.48494 ? 1341 ASP   B CG   1 
ATOM   4399 O  OD1  . ASP   B 2 289 ? 0.54361   -37.98945 -47.40612 1.000 45.13875 ? 1341 ASP   B OD1  1 
ATOM   4400 O  OD2  . ASP   B 2 289 ? 1.26781   -38.77300 -49.32923 1.000 55.05319 ? 1341 ASP   B OD2  1 
ATOM   4401 N  N    . TYR   B 2 290 ? -0.95743  -38.80711 -44.84335 1.000 33.05424 ? 1342 TYR   B N    1 
ATOM   4402 C  CA   . TYR   B 2 290 ? -0.43354  -38.54230 -43.50427 1.000 30.32582 ? 1342 TYR   B CA   1 
ATOM   4403 C  C    . TYR   B 2 290 ? 1.07444   -38.32212 -43.47815 1.000 33.01321 ? 1342 TYR   B C    1 
ATOM   4404 O  O    . TYR   B 2 290 ? 1.68338   -38.36525 -42.40413 1.000 33.94825 ? 1342 TYR   B O    1 
ATOM   4405 C  CB   . TYR   B 2 290 ? -0.81845  -39.66154 -42.51751 1.000 27.98670 ? 1342 TYR   B CB   1 
ATOM   4406 C  CG   . TYR   B 2 290 ? -2.32344  -39.79675 -42.36261 1.000 30.96145 ? 1342 TYR   B CG   1 
ATOM   4407 C  CD1  . TYR   B 2 290 ? -3.02359  -39.00901 -41.45750 1.000 31.05598 ? 1342 TYR   B CD1  1 
ATOM   4408 C  CD2  . TYR   B 2 290 ? -3.04029  -40.68869 -43.15082 1.000 33.76453 ? 1342 TYR   B CD2  1 
ATOM   4409 C  CE1  . TYR   B 2 290 ? -4.40258  -39.11520 -41.33260 1.000 30.55783 ? 1342 TYR   B CE1  1 
ATOM   4410 C  CE2  . TYR   B 2 290 ? -4.40429  -40.80788 -43.03292 1.000 31.55906 ? 1342 TYR   B CE2  1 
ATOM   4411 C  CZ   . TYR   B 2 290 ? -5.08443  -40.01913 -42.12081 1.000 32.46846 ? 1342 TYR   B CZ   1 
ATOM   4412 O  OH   . TYR   B 2 290 ? -6.45142  -40.13832 -42.00590 1.000 31.40146 ? 1342 TYR   B OH   1 
ATOM   4413 N  N    . LYS   B 2 291 ? 1.70247   -38.07183 -44.61807 1.000 32.83073 ? 1343 LYS   B N    1 
ATOM   4414 C  CA   . LYS   B 2 291 ? 3.12643   -37.76766 -44.58793 1.000 40.79475 ? 1343 LYS   B CA   1 
ATOM   4415 C  C    . LYS   B 2 291 ? 3.33923   -36.34974 -44.05865 1.000 38.61872 ? 1343 LYS   B C    1 
ATOM   4416 O  O    . LYS   B 2 291 ? 2.57513   -35.43977 -44.39352 1.000 37.81994 ? 1343 LYS   B O    1 
ATOM   4417 C  CB   . LYS   B 2 291 ? 3.74852   -37.91633 -45.97593 1.000 41.00497 ? 1343 LYS   B CB   1 
ATOM   4418 C  CG   . LYS   B 2 291 ? 3.99972   -39.36722 -46.39919 1.000 47.51500 ? 1343 LYS   B CG   1 
ATOM   4419 C  CD   . LYS   B 2 291 ? 4.49681   -39.44988 -47.83918 1.000 52.03742 ? 1343 LYS   B CD   1 
ATOM   4420 C  CE   . LYS   B 2 291 ? 4.52301   -40.88878 -48.35145 1.000 61.10447 ? 1343 LYS   B CE   1 
ATOM   4421 N  NZ   . LYS   B 2 291 ? 5.55508   -41.73078 -47.68355 1.000 65.16958 ? 1343 LYS   B NZ   1 
ATOM   4422 N  N    . PRO   B 2 292 ? 4.35816   -36.12877 -43.23156 1.000 39.79021 ? 1344 PRO   B N    1 
ATOM   4423 C  CA   . PRO   B 2 292 ? 4.54596   -34.79986 -42.64330 1.000 41.66590 ? 1344 PRO   B CA   1 
ATOM   4424 C  C    . PRO   B 2 292 ? 4.85889   -33.75562 -43.70108 1.000 42.78462 ? 1344 PRO   B C    1 
ATOM   4425 O  O    . PRO   B 2 292 ? 5.44398   -34.04835 -44.74611 1.000 37.09292 ? 1344 PRO   B O    1 
ATOM   4426 C  CB   . PRO   B 2 292 ? 5.72193   -34.99790 -41.68327 1.000 39.81736 ? 1344 PRO   B CB   1 
ATOM   4427 C  CG   . PRO   B 2 292 ? 6.40411   -36.19972 -42.17146 1.000 46.42809 ? 1344 PRO   B CG   1 
ATOM   4428 C  CD   . PRO   B 2 292 ? 5.34024   -37.09175 -42.71869 1.000 41.91256 ? 1344 PRO   B CD   1 
ATOM   4429 N  N    . ILE   B 2 293 ? 4.42973   -32.52773 -43.42687 1.000 35.69818 ? 1345 ILE   B N    1 
ATOM   4430 C  CA   . ILE   B 2 293 ? 4.75063   -31.37153 -44.25064 1.000 38.99601 ? 1345 ILE   B CA   1 
ATOM   4431 C  C    . ILE   B 2 293 ? 5.71048   -30.46555 -43.50241 1.000 48.17723 ? 1345 ILE   B C    1 
ATOM   4432 O  O    . ILE   B 2 293 ? 6.85848   -30.27434 -43.91532 1.000 44.73766 ? 1345 ILE   B O    1 
ATOM   4433 C  CB   . ILE   B 2 293 ? 3.47756   -30.59761 -44.65056 1.000 40.53893 ? 1345 ILE   B CB   1 
ATOM   4434 C  CG1  . ILE   B 2 293 ? 2.55971   -31.47056 -45.49378 1.000 39.19737 ? 1345 ILE   B CG1  1 
ATOM   4435 C  CG2  . ILE   B 2 293 ? 3.84744   -29.31443 -45.37630 1.000 35.48934 ? 1345 ILE   B CG2  1 
ATOM   4436 C  CD1  . ILE   B 2 293 ? 1.23065   -30.80867 -45.77972 1.000 40.00091 ? 1345 ILE   B CD1  1 
ATOM   4437 N  N    . ALA   B 2 294 ? 5.25935   -29.90382 -42.37933 1.000 43.35118 ? 1346 ALA   B N    1 
ATOM   4438 C  CA   . ALA   B 2 294 ? 6.06419   -28.96687 -41.61611 1.000 43.94254 ? 1346 ALA   B CA   1 
ATOM   4439 C  C    . ALA   B 2 294 ? 5.96215   -29.26316 -40.12517 1.000 44.05495 ? 1346 ALA   B C    1 
ATOM   4440 O  O    . ALA   B 2 294 ? 4.95319   -29.78438 -39.63833 1.000 37.84033 ? 1346 ALA   B O    1 
ATOM   4441 C  CB   . ALA   B 2 294 ? 5.63503   -27.52687 -41.89686 1.000 38.89704 ? 1346 ALA   B CB   1 
ATOM   4442 N  N    . THR   B 2 295 ? 7.03107   -28.93817 -39.40805 1.000 37.29690 ? 1347 THR   B N    1 
ATOM   4443 C  CA   . THR   B 2 295 ? 7.04399   -28.94144 -37.95205 1.000 36.65145 ? 1347 THR   B CA   1 
ATOM   4444 C  C    . THR   B 2 295 ? 7.37980   -27.53349 -37.48877 1.000 44.60548 ? 1347 THR   B C    1 
ATOM   4445 O  O    . THR   B 2 295 ? 8.44575   -27.01329 -37.83161 1.000 39.44829 ? 1347 THR   B O    1 
ATOM   4446 C  CB   . THR   B 2 295 ? 8.06208   -29.93542 -37.40919 1.000 43.99451 ? 1347 THR   B CB   1 
ATOM   4447 O  OG1  . THR   B 2 295 ? 7.68427   -31.25539 -37.80646 1.000 38.21072 ? 1347 THR   B OG1  1 
ATOM   4448 C  CG2  . THR   B 2 295 ? 8.12099   -29.84870 -35.88917 1.000 43.20920 ? 1347 THR   B CG2  1 
ATOM   4449 N  N    . ILE   B 2 296 ? 6.47868   -26.92374 -36.71970 1.000 41.39900 ? 1348 ILE   B N    1 
ATOM   4450 C  CA   . ILE   B 2 296 ? 6.60449   -25.53181 -36.29443 1.000 36.45544 ? 1348 ILE   B CA   1 
ATOM   4451 C  C    . ILE   B 2 296 ? 6.73940   -25.49508 -34.78142 1.000 43.52821 ? 1348 ILE   B C    1 
ATOM   4452 O  O    . ILE   B 2 296 ? 5.81141   -25.88233 -34.06054 1.000 42.45555 ? 1348 ILE   B O    1 
ATOM   4453 C  CB   . ILE   B 2 296 ? 5.39741   -24.69487 -36.73834 1.000 39.84261 ? 1348 ILE   B CB   1 
ATOM   4454 C  CG1  . ILE   B 2 296 ? 5.13351   -24.89862 -38.23039 1.000 42.85480 ? 1348 ILE   B CG1  1 
ATOM   4455 C  CG2  . ILE   B 2 296 ? 5.60821   -23.23092 -36.36405 1.000 38.79860 ? 1348 ILE   B CG2  1 
ATOM   4456 C  CD1  . ILE   B 2 296 ? 6.38155   -24.82731 -39.07931 1.000 48.56712 ? 1348 ILE   B CD1  1 
ATOM   4457 N  N    . ASP   B 2 297 ? 7.87331   -25.00203 -34.29826 1.000 34.38394 ? 1349 ASP   B N    1 
ATOM   4458 C  CA   . ASP   B 2 297 ? 8.10822   -24.87727 -32.86423 1.000 41.99897 ? 1349 ASP   B CA   1 
ATOM   4459 C  C    . ASP   B 2 297 ? 8.09202   -23.39334 -32.51295 1.000 45.65529 ? 1349 ASP   B C    1 
ATOM   4460 O  O    . ASP   B 2 297 ? 9.07895   -22.68618 -32.73676 1.000 45.29563 ? 1349 ASP   B O    1 
ATOM   4461 C  CB   . ASP   B 2 297 ? 9.42928   -25.52719 -32.46728 1.000 43.24503 ? 1349 ASP   B CB   1 
ATOM   4462 C  CG   . ASP   B 2 297 ? 9.75118   -25.35443 -30.98823 1.000 53.90645 ? 1349 ASP   B CG   1 
ATOM   4463 O  OD1  . ASP   B 2 297 ? 8.83410   -25.03769 -30.19722 1.000 49.02102 ? 1349 ASP   B OD1  1 
ATOM   4464 O  OD2  . ASP   B 2 297 ? 10.93318  -25.52435 -30.61520 1.000 65.91881 ? 1349 ASP   B OD2  1 
ATOM   4465 N  N    . VAL   B 2 298 ? 6.97093   -22.91758 -31.95592 1.000 37.86837 ? 1350 VAL   B N    1 
ATOM   4466 C  CA   . VAL   B 2 298 ? 6.86874   -21.50266 -31.59666 1.000 38.83550 ? 1350 VAL   B CA   1 
ATOM   4467 C  C    . VAL   B 2 298 ? 7.57563   -21.17382 -30.29656 1.000 41.71938 ? 1350 VAL   B C    1 
ATOM   4468 O  O    . VAL   B 2 298 ? 7.53646   -20.01491 -29.85934 1.000 39.83362 ? 1350 VAL   B O    1 
ATOM   4469 C  CB   . VAL   B 2 298 ? 5.40368   -21.03386 -31.49165 1.000 41.50909 ? 1350 VAL   B CB   1 
ATOM   4470 C  CG1  . VAL   B 2 298 ? 4.68478   -21.27170 -32.80573 1.000 38.76718 ? 1350 VAL   B CG1  1 
ATOM   4471 C  CG2  . VAL   B 2 298 ? 4.68870   -21.72617 -30.32482 1.000 33.41175 ? 1350 VAL   B CG2  1 
ATOM   4472 N  N    . LYS   B 2 299 ? 8.21371   -22.15586 -29.65971 1.000 38.06575 ? 1351 LYS   B N    1 
ATOM   4473 C  CA   . LYS   B 2 299 ? 9.02663   -21.96699 -28.46263 1.000 41.32889 ? 1351 LYS   B CA   1 
ATOM   4474 C  C    . LYS   B 2 299 ? 8.22450   -21.46831 -27.27058 1.000 48.96544 ? 1351 LYS   B C    1 
ATOM   4475 O  O    . LYS   B 2 299 ? 8.80740   -21.13844 -26.23048 1.000 48.17175 ? 1351 LYS   B O    1 
ATOM   4476 C  CB   . LYS   B 2 299 ? 10.19953  -21.01980 -28.73739 1.000 52.04263 ? 1351 LYS   B CB   1 
ATOM   4477 C  CG   . LYS   B 2 299 ? 11.11664  -21.48647 -29.86942 1.000 50.33690 ? 1351 LYS   B CG   1 
ATOM   4478 C  CD   . LYS   B 2 299 ? 11.53981  -22.95345 -29.69568 1.000 57.09321 ? 1351 LYS   B CD   1 
ATOM   4479 C  CE   . LYS   B 2 299 ? 12.33977  -23.18160 -28.41168 1.000 60.86521 ? 1351 LYS   B CE   1 
ATOM   4480 N  NZ   . LYS   B 2 299 ? 11.84588  -24.37380 -27.64993 1.000 62.37035 ? 1351 LYS   B NZ   1 
ATOM   4481 N  N    . ARG   B 2 300 ? 6.90250   -21.39145 -27.40263 1.000 38.00161 ? 1352 ARG   B N    1 
ATOM   4482 C  CA   . ARG   B 2 300 ? 5.99841   -21.12077 -26.29863 1.000 34.76426 ? 1352 ARG   B CA   1 
ATOM   4483 C  C    . ARG   B 2 300 ? 4.93354   -22.21490 -26.27790 1.000 34.03341 ? 1352 ARG   B C    1 
ATOM   4484 O  O    . ARG   B 2 300 ? 4.54566   -22.74075 -27.32502 1.000 31.61267 ? 1352 ARG   B O    1 
ATOM   4485 C  CB   . ARG   B 2 300 ? 5.33724   -19.72982 -26.43641 1.000 29.76708 ? 1352 ARG   B CB   1 
ATOM   4486 C  CG   . ARG   B 2 300 ? 6.29709   -18.54472 -26.35713 1.000 31.26479 ? 1352 ARG   B CG   1 
ATOM   4487 C  CD   . ARG   B 2 300 ? 5.61396   -17.23273 -26.77892 1.000 30.82802 ? 1352 ARG   B CD   1 
ATOM   4488 N  NE   . ARG   B 2 300 ? 5.43003   -17.16948 -28.22392 1.000 33.88588 ? 1352 ARG   B NE   1 
ATOM   4489 C  CZ   . ARG   B 2 300 ? 6.37603   -16.79120 -29.07479 1.000 42.64290 ? 1352 ARG   B CZ   1 
ATOM   4490 N  NH1  . ARG   B 2 300 ? 7.56596   -16.39313 -28.65165 1.000 37.07384 ? 1352 ARG   B NH1  1 
ATOM   4491 N  NH2  . ARG   B 2 300 ? 6.12710   -16.82298 -30.38481 1.000 33.73400 ? 1352 ARG   B NH2  1 
ATOM   4492 N  N    . ASN   B 2 301 ? 4.46652   -22.56919 -25.08599 1.000 29.05700 ? 1353 ASN   B N    1 
ATOM   4493 C  CA   . ASN   B 2 301 ? 3.43564   -23.59433 -24.99424 1.000 31.16467 ? 1353 ASN   B CA   1 
ATOM   4494 C  C    . ASN   B 2 301 ? 2.13861   -23.08037 -25.59621 1.000 31.46229 ? 1353 ASN   B C    1 
ATOM   4495 O  O    . ASN   B 2 301 ? 1.80346   -21.89844 -25.47301 1.000 29.71920 ? 1353 ASN   B O    1 
ATOM   4496 C  CB   . ASN   B 2 301 ? 3.22661   -24.01963 -23.54833 1.000 27.16056 ? 1353 ASN   B CB   1 
ATOM   4497 C  CG   . ASN   B 2 301 ? 4.38768   -24.83058 -23.02442 1.000 40.27584 ? 1353 ASN   B CG   1 
ATOM   4498 O  OD1  . ASN   B 2 301 ? 4.96082   -25.64038 -23.74654 1.000 43.24549 ? 1353 ASN   B OD1  1 
ATOM   4499 N  ND2  . ASN   B 2 301 ? 4.76258   -24.59777 -21.78336 1.000 44.11828 ? 1353 ASN   B ND2  1 
ATOM   4500 N  N    . ILE   B 2 302 ? 1.40075   -23.98334 -26.24842 1.000 25.56956 ? 1354 ILE   B N    1 
ATOM   4501 C  CA   . ILE   B 2 302 ? 0.22175   -23.62334 -27.02542 1.000 26.06110 ? 1354 ILE   B CA   1 
ATOM   4502 C  C    . ILE   B 2 302 ? -1.04225  -23.93964 -26.23855 1.000 25.34162 ? 1354 ILE   B C    1 
ATOM   4503 O  O    . ILE   B 2 302 ? -1.13516  -24.98078 -25.57675 1.000 26.15411 ? 1354 ILE   B O    1 
ATOM   4504 C  CB   . ILE   B 2 302 ? 0.23191   -24.34308 -28.38455 1.000 26.29314 ? 1354 ILE   B CB   1 
ATOM   4505 C  CG1  . ILE   B 2 302 ? 1.42890   -23.85478 -29.21440 1.000 25.79596 ? 1354 ILE   B CG1  1 
ATOM   4506 C  CG2  . ILE   B 2 302 ? -1.07808  -24.11410 -29.11758 1.000 22.17937 ? 1354 ILE   B CG2  1 
ATOM   4507 C  CD1  . ILE   B 2 302 ? 1.75307   -24.71551 -30.39654 1.000 25.61527 ? 1354 ILE   B CD1  1 
ATOM   4508 N  N    . PHE   B 2 303 ? -2.01536  -23.03074 -26.30943 1.000 21.84304 ? 1355 PHE   B N    1 
ATOM   4509 C  CA   . PHE   B 2 303 ? -3.33737  -23.21802 -25.71554 1.000 21.41404 ? 1355 PHE   B CA   1 
ATOM   4510 C  C    . PHE   B 2 303 ? -4.40627  -23.58696 -26.73566 1.000 23.52937 ? 1355 PHE   B C    1 
ATOM   4511 O  O    . PHE   B 2 303 ? -5.34220  -24.32413 -26.40485 1.000 25.40867 ? 1355 PHE   B O    1 
ATOM   4512 C  CB   . PHE   B 2 303 ? -3.77857  -21.93821 -24.99232 1.000 22.41535 ? 1355 PHE   B CB   1 
ATOM   4513 C  CG   . PHE   B 2 303 ? -3.36765  -21.88143 -23.54928 1.000 20.97518 ? 1355 PHE   B CG   1 
ATOM   4514 C  CD1  . PHE   B 2 303 ? -2.05770  -21.61234 -23.19916 1.000 24.75007 ? 1355 PHE   B CD1  1 
ATOM   4515 C  CD2  . PHE   B 2 303 ? -4.29368  -22.11073 -22.54338 1.000 21.49665 ? 1355 PHE   B CD2  1 
ATOM   4516 C  CE1  . PHE   B 2 303 ? -1.68078  -21.56154 -21.87413 1.000 25.91562 ? 1355 PHE   B CE1  1 
ATOM   4517 C  CE2  . PHE   B 2 303 ? -3.92576  -22.05794 -21.22435 1.000 24.06576 ? 1355 PHE   B CE2  1 
ATOM   4518 C  CZ   . PHE   B 2 303 ? -2.61781  -21.78284 -20.88523 1.000 27.19773 ? 1355 PHE   B CZ   1 
ATOM   4519 N  N    . ASP   B 2 304 ? -4.29926  -23.08371 -27.96156 1.000 23.97369 ? 1356 ASP   B N    1 
ATOM   4520 C  CA   . ASP   B 2 304 ? -5.31218  -23.33164 -28.97466 1.000 25.62218 ? 1356 ASP   B CA   1 
ATOM   4521 C  C    . ASP   B 2 304 ? -4.76416  -22.87032 -30.31755 1.000 26.83043 ? 1356 ASP   B C    1 
ATOM   4522 O  O    . ASP   B 2 304 ? -3.78625  -22.11819 -30.37935 1.000 23.53661 ? 1356 ASP   B O    1 
ATOM   4523 C  CB   . ASP   B 2 304 ? -6.61529  -22.59986 -28.64260 1.000 21.58217 ? 1356 ASP   B CB   1 
ATOM   4524 C  CG   . ASP   B 2 304 ? -7.83417  -23.26390 -29.25079 1.000 23.76441 ? 1356 ASP   B CG   1 
ATOM   4525 O  OD1  . ASP   B 2 304 ? -7.71301  -24.37278 -29.81199 1.000 25.54115 ? 1356 ASP   B OD1  1 
ATOM   4526 O  OD2  . ASP   B 2 304 ? -8.92825  -22.67205 -29.16174 1.000 25.02317 ? 1356 ASP   B OD2  1 
ATOM   4527 N  N    . LEU   B 2 305 ? -5.39405  -23.34820 -31.39067 1.000 22.59153 ? 1357 LEU   B N    1 
ATOM   4528 C  CA   . LEU   B 2 305 ? -5.15404  -22.77792 -32.70555 1.000 24.87875 ? 1357 LEU   B CA   1 
ATOM   4529 C  C    . LEU   B 2 305 ? -6.36697  -23.01790 -33.58666 1.000 30.51767 ? 1357 LEU   B C    1 
ATOM   4530 O  O    . LEU   B 2 305 ? -7.18687  -23.90605 -33.32988 1.000 31.58120 ? 1357 LEU   B O    1 
ATOM   4531 C  CB   . LEU   B 2 305 ? -3.87894  -23.33264 -33.35459 1.000 31.29867 ? 1357 LEU   B CB   1 
ATOM   4532 C  CG   . LEU   B 2 305 ? -3.69974  -24.71250 -33.98084 1.000 36.04297 ? 1357 LEU   B CG   1 
ATOM   4533 C  CD1  . LEU   B 2 305 ? -4.50065  -24.88736 -35.24991 1.000 38.95857 ? 1357 LEU   B CD1  1 
ATOM   4534 C  CD2  . LEU   B 2 305 ? -2.21870  -24.88626 -34.29279 1.000 37.53928 ? 1357 LEU   B CD2  1 
ATOM   4535 N  N    . CYS   B 2 306 ? -6.47901  -22.19972 -34.62551 1.000 24.48549 ? 1358 CYS   B N    1 
ATOM   4536 C  CA   . CYS   B 2 306 ? -7.62095  -22.26369 -35.52059 1.000 25.37890 ? 1358 CYS   B CA   1 
ATOM   4537 C  C    . CYS   B 2 306 ? -7.21896  -21.60539 -36.82644 1.000 30.08585 ? 1358 CYS   B C    1 
ATOM   4538 O  O    . CYS   B 2 306 ? -6.19704  -20.91425 -36.90026 1.000 29.04467 ? 1358 CYS   B O    1 
ATOM   4539 C  CB   . CYS   B 2 306 ? -8.85807  -21.58695 -34.90853 1.000 25.90247 ? 1358 CYS   B CB   1 
ATOM   4540 S  SG   . CYS   B 2 306 ? -8.68330  -19.78498 -34.64918 1.000 29.66607 ? 1358 CYS   B SG   1 
ATOM   4541 N  N    . THR   B 2 307 ? -7.99987  -21.87529 -37.86854 1.000 32.80385 ? 1359 THR   B N    1 
ATOM   4542 C  CA   . THR   B 2 307 ? -7.80788  -21.24902 -39.17141 1.000 34.42937 ? 1359 THR   B CA   1 
ATOM   4543 C  C    . THR   B 2 307 ? -9.12693  -20.64010 -39.61836 1.000 30.28567 ? 1359 THR   B C    1 
ATOM   4544 O  O    . THR   B 2 307 ? -10.19192 -20.97933 -39.09549 1.000 28.99624 ? 1359 THR   B O    1 
ATOM   4545 C  CB   . THR   B 2 307 ? -7.31670  -22.23476 -40.24757 1.000 31.31848 ? 1359 THR   B CB   1 
ATOM   4546 O  OG1  . THR   B 2 307 ? -8.28356  -23.28485 -40.40882 1.000 40.13070 ? 1359 THR   B OG1  1 
ATOM   4547 C  CG2  . THR   B 2 307 ? -5.97165  -22.82367 -39.86060 1.000 43.90834 ? 1359 THR   B CG2  1 
ATOM   4548 N  N    . ASP   B 2 308 ? -9.03799  -19.72590 -40.58319 1.000 32.66688 ? 1360 ASP   B N    1 
ATOM   4549 C  CA   . ASP   B 2 308 ? -10.20704 -19.05994 -41.13312 1.000 33.37537 ? 1360 ASP   B CA   1 
ATOM   4550 C  C    . ASP   B 2 308 ? -10.79088 -19.90180 -42.26731 1.000 35.43461 ? 1360 ASP   B C    1 
ATOM   4551 O  O    . ASP   B 2 308 ? -10.15773 -20.82563 -42.78145 1.000 34.19371 ? 1360 ASP   B O    1 
ATOM   4552 C  CB   . ASP   B 2 308 ? -9.85819  -17.64181 -41.60984 1.000 30.68288 ? 1360 ASP   B CB   1 
ATOM   4553 C  CG   . ASP   B 2 308 ? -8.79713  -17.61747 -42.72977 1.000 34.57039 ? 1360 ASP   B CG   1 
ATOM   4554 O  OD1  . ASP   B 2 308 ? -7.78304  -18.34136 -42.64486 1.000 38.74107 ? 1360 ASP   B OD1  1 
ATOM   4555 O  OD2  . ASP   B 2 308 ? -8.97217  -16.85131 -43.69864 1.000 41.70837 ? 1360 ASP   B OD2  1 
ATOM   4556 N  N    . THR   B 2 309 ? -12.01989 -19.56687 -42.66132 1.000 36.21244 ? 1361 THR   B N    1 
ATOM   4557 C  CA   . THR   B 2 309 ? -12.72274 -20.38877 -43.64351 1.000 35.97278 ? 1361 THR   B CA   1 
ATOM   4558 C  C    . THR   B 2 309 ? -11.94166 -20.50543 -44.94549 1.000 39.28353 ? 1361 THR   B C    1 
ATOM   4559 O  O    . THR   B 2 309 ? -12.03349 -21.52631 -45.63669 1.000 42.21701 ? 1361 THR   B O    1 
ATOM   4560 C  CB   . THR   B 2 309 ? -14.10380 -19.80689 -43.91248 1.000 37.75902 ? 1361 THR   B CB   1 
ATOM   4561 O  OG1  . THR   B 2 309 ? -13.94893 -18.47678 -44.41322 1.000 47.93511 ? 1361 THR   B OG1  1 
ATOM   4562 C  CG2  . THR   B 2 309 ? -14.91387 -19.76023 -42.63351 1.000 37.71092 ? 1361 THR   B CG2  1 
ATOM   4563 N  N    . LYS   B 2 310 ? -11.17576 -19.47727 -45.29326 1.000 36.16545 ? 1362 LYS   B N    1 
ATOM   4564 C  CA   . LYS   B 2 310 ? -10.38770 -19.45695 -46.51721 1.000 41.65178 ? 1362 LYS   B CA   1 
ATOM   4565 C  C    . LYS   B 2 310 ? -8.98864  -20.02181 -46.33224 1.000 37.41481 ? 1362 LYS   B C    1 
ATOM   4566 O  O    . LYS   B 2 310 ? -8.23758  -20.10754 -47.30421 1.000 36.93904 ? 1362 LYS   B O    1 
ATOM   4567 C  CB   . LYS   B 2 310 ? -10.28784 -18.02483 -47.05293 1.000 45.57349 ? 1362 LYS   B CB   1 
ATOM   4568 C  CG   . LYS   B 2 310 ? -11.61189 -17.42691 -47.48889 1.000 44.21319 ? 1362 LYS   B CG   1 
ATOM   4569 C  CD   . LYS   B 2 310 ? -11.61109 -15.90895 -47.30960 1.000 59.93230 ? 1362 LYS   B CD   1 
ATOM   4570 C  CE   . LYS   B 2 310 ? -12.73513 -15.24493 -48.10454 1.000 69.42526 ? 1362 LYS   B CE   1 
ATOM   4571 N  NZ   . LYS   B 2 310 ? -14.07307 -15.84515 -47.81573 1.000 70.83824 ? 1362 LYS   B NZ   1 
ATOM   4572 N  N    . ASP   B 2 311 ? -8.61066  -20.39600 -45.11429 1.000 34.60487 ? 1363 ASP   B N    1 
ATOM   4573 C  CA   . ASP   B 2 311 ? -7.27661  -20.93388 -44.86732 1.000 34.12483 ? 1363 ASP   B CA   1 
ATOM   4574 C  C    . ASP   B 2 311 ? -6.17971  -19.94767 -45.25407 1.000 34.23731 ? 1363 ASP   B C    1 
ATOM   4575 O  O    . ASP   B 2 311 ? -5.10263  -20.34846 -45.70209 1.000 32.68415 ? 1363 ASP   B O    1 
ATOM   4576 C  CB   . ASP   B 2 311 ? -7.07741  -22.25772 -45.60656 1.000 34.58220 ? 1363 ASP   B CB   1 
ATOM   4577 C  CG   . ASP   B 2 311 ? -7.99330  -23.33992 -45.09181 1.000 45.81871 ? 1363 ASP   B CG   1 
ATOM   4578 O  OD1  . ASP   B 2 311 ? -7.97834  -23.57716 -43.85986 1.000 38.98955 ? 1363 ASP   B OD1  1 
ATOM   4579 O  OD2  . ASP   B 2 311 ? -8.73019  -23.93386 -45.91796 1.000 51.93580 ? 1363 ASP   B OD2  1 
ATOM   4580 N  N    . CYS   B 2 312 ? -6.44287  -18.64874 -45.09084 1.000 36.72603 ? 1364 CYS   B N    1 
ATOM   4581 C  CA   . CYS   B 2 312 ? -5.38899  -17.65557 -45.26460 1.000 32.58829 ? 1364 CYS   B CA   1 
ATOM   4582 C  C    . CYS   B 2 312 ? -4.55707  -17.50471 -44.00552 1.000 33.58377 ? 1364 CYS   B C    1 
ATOM   4583 O  O    . CYS   B 2 312 ? -3.36211  -17.19855 -44.08540 1.000 36.63601 ? 1364 CYS   B O    1 
ATOM   4584 C  CB   . CYS   B 2 312 ? -5.98813  -16.29558 -45.64337 1.000 37.69133 ? 1364 CYS   B CB   1 
ATOM   4585 S  SG   . CYS   B 2 312 ? -6.97105  -16.30741 -47.16443 1.000 51.72251 ? 1364 CYS   B SG   1 
ATOM   4586 N  N    . TYR   B 2 313 ? -5.16211  -17.75200 -42.84460 1.000 33.66879 ? 1365 TYR   B N    1 
ATOM   4587 C  CA   . TYR   B 2 313 ? -4.57822  -17.39817 -41.56650 1.000 32.55318 ? 1365 TYR   B CA   1 
ATOM   4588 C  C    . TYR   B 2 313 ? -4.66513  -18.55337 -40.58773 1.000 37.20057 ? 1365 TYR   B C    1 
ATOM   4589 O  O    . TYR   B 2 313 ? -5.60703  -19.35148 -40.60593 1.000 33.66246 ? 1365 TYR   B O    1 
ATOM   4590 C  CB   . TYR   B 2 313 ? -5.27440  -16.18637 -40.95631 1.000 39.55176 ? 1365 TYR   B CB   1 
ATOM   4591 C  CG   . TYR   B 2 313 ? -5.13851  -14.94020 -41.79207 1.000 38.25861 ? 1365 TYR   B CG   1 
ATOM   4592 C  CD1  . TYR   B 2 313 ? -3.89357  -14.34601 -41.98989 1.000 38.32445 ? 1365 TYR   B CD1  1 
ATOM   4593 C  CD2  . TYR   B 2 313 ? -6.24854  -14.35822 -42.39302 1.000 41.66687 ? 1365 TYR   B CD2  1 
ATOM   4594 C  CE1  . TYR   B 2 313 ? -3.76166  -13.20485 -42.75667 1.000 40.12455 ? 1365 TYR   B CE1  1 
ATOM   4595 C  CE2  . TYR   B 2 313 ? -6.12564  -13.20906 -43.16480 1.000 45.33342 ? 1365 TYR   B CE2  1 
ATOM   4596 C  CZ   . TYR   B 2 313 ? -4.87970  -12.63688 -43.34062 1.000 45.20300 ? 1365 TYR   B CZ   1 
ATOM   4597 O  OH   . TYR   B 2 313 ? -4.75080  -11.49771 -44.11140 1.000 46.40896 ? 1365 TYR   B OH   1 
ATOM   4598 N  N    . LEU   B 2 314 ? -3.66417  -18.61741 -39.72268 1.000 30.57612 ? 1366 LEU   B N    1 
ATOM   4599 C  CA   . LEU   B 2 314 ? -3.67213  -19.47963 -38.55585 1.000 31.56459 ? 1366 LEU   B CA   1 
ATOM   4600 C  C    . LEU   B 2 314 ? -3.56130  -18.58085 -37.33367 1.000 34.28344 ? 1366 LEU   B C    1 
ATOM   4601 O  O    . LEU   B 2 314 ? -2.65141  -17.74975 -37.25847 1.000 29.05485 ? 1366 LEU   B O    1 
ATOM   4602 C  CB   . LEU   B 2 314 ? -2.50800  -20.46648 -38.62697 1.000 28.71655 ? 1366 LEU   B CB   1 
ATOM   4603 C  CG   . LEU   B 2 314 ? -2.27994  -21.48766 -37.52415 1.000 32.69181 ? 1366 LEU   B CG   1 
ATOM   4604 C  CD1  . LEU   B 2 314 ? -3.37681  -22.53879 -37.56041 1.000 37.65180 ? 1366 LEU   B CD1  1 
ATOM   4605 C  CD2  . LEU   B 2 314 ? -0.91385  -22.13546 -37.69320 1.000 34.31801 ? 1366 LEU   B CD2  1 
ATOM   4606 N  N    . ALA   B 2 315 ? -4.49234  -18.71014 -36.39675 1.000 25.34085 ? 1367 ALA   B N    1 
ATOM   4607 C  CA   . ALA   B 2 315 ? -4.36449  -18.01437 -35.12261 1.000 23.32209 ? 1367 ALA   B CA   1 
ATOM   4608 C  C    . ALA   B 2 315 ? -3.96943  -19.02352 -34.05678 1.000 24.60421 ? 1367 ALA   B C    1 
ATOM   4609 O  O    . ALA   B 2 315 ? -4.56630  -20.10461 -33.97201 1.000 24.94248 ? 1367 ALA   B O    1 
ATOM   4610 C  CB   . ALA   B 2 315 ? -5.66260  -17.30160 -34.73754 1.000 23.20236 ? 1367 ALA   B CB   1 
ATOM   4611 N  N    . VAL   B 2 316 ? -2.98252  -18.66655 -33.24266 1.000 24.01903 ? 1368 VAL   B N    1 
ATOM   4612 C  CA   . VAL   B 2 316 ? -2.45247  -19.54668 -32.20479 1.000 22.38880 ? 1368 VAL   B CA   1 
ATOM   4613 C  C    . VAL   B 2 316 ? -2.38363  -18.77492 -30.89164 1.000 26.92079 ? 1368 VAL   B C    1 
ATOM   4614 O  O    . VAL   B 2 316 ? -1.89877  -17.63987 -30.85940 1.000 26.77251 ? 1368 VAL   B O    1 
ATOM   4615 C  CB   . VAL   B 2 316 ? -1.06138  -20.08644 -32.58482 1.000 22.83224 ? 1368 VAL   B CB   1 
ATOM   4616 C  CG1  . VAL   B 2 316 ? -0.56331  -21.08758 -31.53398 1.000 21.20092 ? 1368 VAL   B CG1  1 
ATOM   4617 C  CG2  . VAL   B 2 316 ? -1.08623  -20.70218 -33.98794 1.000 25.93295 ? 1368 VAL   B CG2  1 
ATOM   4618 N  N    . ILE   B 2 317 ? -2.86662  -19.38119 -29.80879 1.000 23.09633 ? 1369 ILE   B N    1 
ATOM   4619 C  CA   . ILE   B 2 317 ? -2.70576  -18.80242 -28.47867 1.000 20.99391 ? 1369 ILE   B CA   1 
ATOM   4620 C  C    . ILE   B 2 317 ? -1.43272  -19.37738 -27.87871 1.000 25.81583 ? 1369 ILE   B C    1 
ATOM   4621 O  O    . ILE   B 2 317 ? -1.32358  -20.59340 -27.69093 1.000 26.13602 ? 1369 ILE   B O    1 
ATOM   4622 C  CB   . ILE   B 2 317 ? -3.91177  -19.08674 -27.57479 1.000 22.17312 ? 1369 ILE   B CB   1 
ATOM   4623 C  CG1  . ILE   B 2 317 ? -5.22479  -18.64377 -28.23077 1.000 26.44203 ? 1369 ILE   B CG1  1 
ATOM   4624 C  CG2  . ILE   B 2 317 ? -3.72493  -18.40097 -26.22765 1.000 21.64022 ? 1369 ILE   B CG2  1 
ATOM   4625 C  CD1  . ILE   B 2 317 ? -5.23494  -17.20169 -28.65950 1.000 27.32082 ? 1369 ILE   B CD1  1 
ATOM   4626 N  N    . GLU   B 2 318 ? -0.48284  -18.50132 -27.56249 1.000 24.70718 ? 1370 GLU   B N    1 
ATOM   4627 C  CA   . GLU   B 2 318 ? 0.84718   -18.88324 -27.11449 1.000 23.97346 ? 1370 GLU   B CA   1 
ATOM   4628 C  C    . GLU   B 2 318 ? 1.12703   -18.25847 -25.76036 1.000 26.57517 ? 1370 GLU   B C    1 
ATOM   4629 O  O    . GLU   B 2 318 ? 0.85887   -17.07254 -25.53815 1.000 27.08044 ? 1370 GLU   B O    1 
ATOM   4630 C  CB   . GLU   B 2 318 ? 1.91118   -18.44692 -28.12635 1.000 26.86098 ? 1370 GLU   B CB   1 
ATOM   4631 C  CG   . GLU   B 2 318 ? 1.61132   -18.94669 -29.54646 1.000 27.42033 ? 1370 GLU   B CG   1 
ATOM   4632 C  CD   . GLU   B 2 318 ? 2.64032   -18.49637 -30.57032 1.000 31.60777 ? 1370 GLU   B CD   1 
ATOM   4633 O  OE1  . GLU   B 2 318 ? 3.66622   -17.90432 -30.17515 1.000 34.21617 ? 1370 GLU   B OE1  1 
ATOM   4634 O  OE2  . GLU   B 2 318 ? 2.42041   -18.73617 -31.77338 1.000 33.24174 ? 1370 GLU   B OE2  1 
ATOM   4635 N  N    . ASN   B 2 319 ? 1.68308   -19.05757 -24.86148 1.000 25.70841 ? 1371 ASN   B N    1 
ATOM   4636 C  CA   . ASN   B 2 319 ? 1.94895   -18.61679 -23.50638 1.000 26.43860 ? 1371 ASN   B CA   1 
ATOM   4637 C  C    . ASN   B 2 319 ? 3.36988   -18.06364 -23.41020 1.000 27.88797 ? 1371 ASN   B C    1 
ATOM   4638 O  O    . ASN   B 2 319 ? 4.33698   -18.79347 -23.64228 1.000 30.31921 ? 1371 ASN   B O    1 
ATOM   4639 C  CB   . ASN   B 2 319 ? 1.75004   -19.78000 -22.54261 1.000 32.03509 ? 1371 ASN   B CB   1 
ATOM   4640 C  CG   . ASN   B 2 319 ? 1.91591   -19.37525 -21.10352 1.000 35.50285 ? 1371 ASN   B CG   1 
ATOM   4641 O  OD1  . ASN   B 2 319 ? 1.82175   -18.19233 -20.76131 1.000 30.62222 ? 1371 ASN   B OD1  1 
ATOM   4642 N  ND2  . ASN   B 2 319 ? 2.16298   -20.35938 -20.24470 1.000 37.25303 ? 1371 ASN   B ND2  1 
ATOM   4643 N  N    . GLN   B 2 320 ? 3.48870   -16.76968 -23.07495 1.000 28.71445 ? 1372 GLN   B N    1 
ATOM   4644 C  CA   . GLN   B 2 320 ? 4.78961   -16.15658 -22.79876 1.000 31.69607 ? 1372 GLN   B CA   1 
ATOM   4645 C  C    . GLN   B 2 320 ? 5.34258   -16.53477 -21.43980 1.000 31.80584 ? 1372 GLN   B C    1 
ATOM   4646 O  O    . GLN   B 2 320 ? 6.54955   -16.38966 -21.21371 1.000 36.99948 ? 1372 GLN   B O    1 
ATOM   4647 C  CB   . GLN   B 2 320 ? 4.71442   -14.63259 -22.79848 1.000 27.50968 ? 1372 GLN   B CB   1 
ATOM   4648 C  CG   . GLN   B 2 320 ? 4.16041   -14.00243 -24.00039 1.000 37.72032 ? 1372 GLN   B CG   1 
ATOM   4649 C  CD   . GLN   B 2 320 ? 4.56924   -12.54837 -24.05809 1.000 35.95981 ? 1372 GLN   B CD   1 
ATOM   4650 O  OE1  . GLN   B 2 320 ? 3.99910   -11.69857 -23.37096 1.000 35.41154 ? 1372 GLN   B OE1  1 
ATOM   4651 N  NE2  . GLN   B 2 320 ? 5.58925   -12.26009 -24.86098 1.000 33.21392 ? 1372 GLN   B NE2  1 
ATOM   4652 N  N    . GLY   B 2 321 ? 4.47458   -16.94305 -20.51593 1.000 31.38031 ? 1373 GLY   B N    1 
ATOM   4653 C  CA   . GLY   B 2 321 ? 4.85655   -17.27526 -19.15497 1.000 34.83841 ? 1373 GLY   B CA   1 
ATOM   4654 C  C    . GLY   B 2 321 ? 6.13364   -18.08013 -19.02905 1.000 38.21469 ? 1373 GLY   B C    1 
ATOM   4655 O  O    . GLY   B 2 321 ? 6.31380   -19.10798 -19.69323 1.000 32.18429 ? 1373 GLY   B O    1 
ATOM   4656 N  N    . SER   B 2 322 ? 7.02554   -17.62718 -18.14692 1.000 36.58251 ? 1374 SER   B N    1 
ATOM   4657 C  CA   . SER   B 2 322 ? 8.35260   -18.22204 -18.05196 1.000 36.16643 ? 1374 SER   B CA   1 
ATOM   4658 C  C    . SER   B 2 322 ? 8.33673   -19.59117 -17.38222 1.000 41.93693 ? 1374 SER   B C    1 
ATOM   4659 O  O    . SER   B 2 322 ? 9.30883   -20.34303 -17.51431 1.000 37.32676 ? 1374 SER   B O    1 
ATOM   4660 C  CB   . SER   B 2 322 ? 9.27945   -17.26907 -17.29973 1.000 33.52358 ? 1374 SER   B CB   1 
ATOM   4661 O  OG   . SER   B 2 322 ? 8.63432   -16.78437 -16.12467 1.000 41.12089 ? 1374 SER   B OG   1 
ATOM   4662 N  N    . MET   B 2 323 ? 7.26974   -19.92543 -16.66534 1.000 33.42702 ? 1375 MET   B N    1 
ATOM   4663 C  CA   . MET   B 2 323 ? 7.10986   -21.22158 -16.02159 1.000 42.40981 ? 1375 MET   B CA   1 
ATOM   4664 C  C    . MET   B 2 323 ? 5.82397   -21.88064 -16.50079 1.000 44.29017 ? 1375 MET   B C    1 
ATOM   4665 O  O    . MET   B 2 323 ? 5.04899   -22.43688 -15.71793 1.000 41.89350 ? 1375 MET   B O    1 
ATOM   4666 C  CB   . MET   B 2 323 ? 7.11476   -21.08186 -14.49956 1.000 40.30394 ? 1375 MET   B CB   1 
ATOM   4667 C  CG   . MET   B 2 323 ? 7.22288   -22.39499 -13.74381 1.000 48.01257 ? 1375 MET   B CG   1 
ATOM   4668 S  SD   . MET   B 2 323 ? 8.85898   -23.14176 -13.94586 1.000 46.93413 ? 1375 MET   B SD   1 
ATOM   4669 C  CE   . MET   B 2 323 ? 9.88979   -21.95179 -13.11558 1.000 39.20972 ? 1375 MET   B CE   1 
ATOM   4670 N  N    . ASP   B 2 324 ? 5.57403   -21.79243 -17.80178 1.000 46.86216 ? 1376 ASP   B N    1 
ATOM   4671 C  CA   . ASP   B 2 324 ? 4.37213   -22.36146 -18.42295 1.000 48.78322 ? 1376 ASP   B CA   1 
ATOM   4672 C  C    . ASP   B 2 324 ? 3.14802   -21.74473 -17.74290 1.000 51.00062 ? 1376 ASP   B C    1 
ATOM   4673 O  O    . ASP   B 2 324 ? 3.05886   -20.50576 -17.66468 1.000 49.61008 ? 1376 ASP   B O    1 
ATOM   4674 C  CB   . ASP   B 2 324 ? 4.45131   -23.88745 -18.38524 1.000 52.06567 ? 1376 ASP   B CB   1 
ATOM   4675 C  CG   . ASP   B 2 324 ? 3.41844   -24.53441 -19.29042 1.000 56.76908 ? 1376 ASP   B CG   1 
ATOM   4676 O  OD1  . ASP   B 2 324 ? 2.98841   -23.84728 -20.25031 1.000 52.21999 ? 1376 ASP   B OD1  1 
ATOM   4677 O  OD2  . ASP   B 2 324 ? 3.03357   -25.70150 -19.04066 1.000 48.92627 ? 1376 ASP   B OD2  1 
ATOM   4678 N  N    . ALA   B 2 325 ? 2.19909   -22.54095 -17.23411 1.000 50.72200 ? 1377 ALA   B N    1 
ATOM   4679 C  CA   . ALA   B 2 325 ? 0.89600   -22.03718 -16.80908 1.000 51.85392 ? 1377 ALA   B CA   1 
ATOM   4680 C  C    . ALA   B 2 325 ? 0.85787   -21.58746 -15.35600 1.000 53.34727 ? 1377 ALA   B C    1 
ATOM   4681 O  O    . ALA   B 2 325 ? -0.18322  -21.08868 -14.90596 1.000 46.09206 ? 1377 ALA   B O    1 
ATOM   4682 C  CB   . ALA   B 2 325 ? -0.19286  -23.09327 -17.05034 1.000 52.81687 ? 1377 ALA   B CB   1 
ATOM   4683 N  N    . LEU   B 2 326 ? 1.95285   -21.75147 -14.60697 1.000 52.17307 ? 1378 LEU   B N    1 
ATOM   4684 C  CA   . LEU   B 2 326 ? 2.03770   -21.11471 -13.29785 1.000 56.29434 ? 1378 LEU   B CA   1 
ATOM   4685 C  C    . LEU   B 2 326 ? 1.74552   -19.62472 -13.41658 1.000 53.76692 ? 1378 LEU   B C    1 
ATOM   4686 O  O    . LEU   B 2 326 ? 0.76143   -19.11395 -12.86654 1.000 53.86133 ? 1378 LEU   B O    1 
ATOM   4687 C  CB   . LEU   B 2 326 ? 3.41769   -21.33966 -12.68881 1.000 57.00328 ? 1378 LEU   B CB   1 
ATOM   4688 C  CG   . LEU   B 2 326 ? 3.56780   -22.58280 -11.82104 1.000 60.67647 ? 1378 LEU   B CG   1 
ATOM   4689 C  CD1  . LEU   B 2 326 ? 4.00799   -23.78859 -12.64124 1.000 59.87356 ? 1378 LEU   B CD1  1 
ATOM   4690 C  CD2  . LEU   B 2 326 ? 4.55070   -22.28389 -10.71093 1.000 47.56696 ? 1378 LEU   B CD2  1 
ATOM   4691 N  N    . ASN   B 2 327 ? 2.59948   -18.91848 -14.15040 1.000 52.53565 ? 1379 ASN   B N    1 
ATOM   4692 C  CA   . ASN   B 2 327 ? 2.37732   -17.51345 -14.47115 1.000 46.89837 ? 1379 ASN   B CA   1 
ATOM   4693 C  C    . ASN   B 2 327 ? 1.92039   -17.41223 -15.92415 1.000 46.25093 ? 1379 ASN   B C    1 
ATOM   4694 O  O    . ASN   B 2 327 ? 2.65339   -16.99997 -16.82804 1.000 42.43697 ? 1379 ASN   B O    1 
ATOM   4695 C  CB   . ASN   B 2 327 ? 3.64621   -16.70834 -14.21293 1.000 42.64443 ? 1379 ASN   B CB   1 
ATOM   4696 C  CG   . ASN   B 2 327 ? 4.81831   -17.17503 -15.07595 1.000 44.23264 ? 1379 ASN   B CG   1 
ATOM   4697 O  OD1  . ASN   B 2 327 ? 4.81148   -18.29093 -15.61416 1.000 43.43886 ? 1379 ASN   B OD1  1 
ATOM   4698 N  ND2  . ASN   B 2 327 ? 5.83122   -16.32389 -15.20573 1.000 39.46018 ? 1379 ASN   B ND2  1 
ATOM   4699 N  N    . MET   B 2 328 ? 0.68545   -17.84534 -16.14430 1.000 42.15806 ? 1380 MET   B N    1 
ATOM   4700 C  CA   . MET   B 2 328 ? 0.11152   -17.78315 -17.47832 1.000 39.12421 ? 1380 MET   B CA   1 
ATOM   4701 C  C    . MET   B 2 328 ? 0.08937   -16.34706 -17.99305 1.000 30.88523 ? 1380 MET   B C    1 
ATOM   4702 O  O    . MET   B 2 328 ? -0.35878  -15.43524 -17.30190 1.000 30.70905 ? 1380 MET   B O    1 
ATOM   4703 C  CB   . MET   B 2 328 ? -1.30041  -18.34833 -17.46050 1.000 38.76415 ? 1380 MET   B CB   1 
ATOM   4704 C  CG   . MET   B 2 328 ? -1.89232  -18.50414 -18.83057 1.000 35.29613 ? 1380 MET   B CG   1 
ATOM   4705 S  SD   . MET   B 2 328 ? -3.59527  -18.99239 -18.61875 1.000 35.68277 ? 1380 MET   B SD   1 
ATOM   4706 C  CE   . MET   B 2 328 ? -4.39230  -18.13623 -19.96463 1.000 28.81052 ? 1380 MET   B CE   1 
ATOM   4707 N  N    . ASP   B 2 329 ? 0.56242   -16.15277 -19.22399 1.000 29.49636 ? 1381 ASP   B N    1 
ATOM   4708 C  CA   . ASP   B 2 329 ? 0.58929   -14.82465 -19.83274 1.000 31.74074 ? 1381 ASP   B CA   1 
ATOM   4709 C  C    . ASP   B 2 329 ? 0.53139   -14.99137 -21.34777 1.000 28.60272 ? 1381 ASP   B C    1 
ATOM   4710 O  O    . ASP   B 2 329 ? 1.56243   -15.00012 -22.02172 1.000 28.97502 ? 1381 ASP   B O    1 
ATOM   4711 C  CB   . ASP   B 2 329 ? 1.84317   -14.06758 -19.40353 1.000 30.46563 ? 1381 ASP   B CB   1 
ATOM   4712 C  CG   . ASP   B 2 329 ? 1.85102   -12.62249 -19.87425 1.000 36.68427 ? 1381 ASP   B CG   1 
ATOM   4713 O  OD1  . ASP   B 2 329 ? 0.78094   -11.97962 -19.85219 1.000 29.77441 ? 1381 ASP   B OD1  1 
ATOM   4714 O  OD2  . ASP   B 2 329 ? 2.92798   -12.13628 -20.26610 1.000 37.32276 ? 1381 ASP   B OD2  1 
ATOM   4715 N  N    . THR   B 2 330 ? -0.66756  -15.18142 -21.88187 1.000 24.79834 ? 1382 THR   B N    1 
ATOM   4716 C  CA   . THR   B 2 330 ? -0.77543  -15.64417 -23.25597 1.000 24.42773 ? 1382 THR   B CA   1 
ATOM   4717 C  C    . THR   B 2 330 ? -0.89752  -14.48400 -24.23875 1.000 27.04330 ? 1382 THR   B C    1 
ATOM   4718 O  O    . THR   B 2 330 ? -1.42066  -13.41512 -23.91958 1.000 26.21479 ? 1382 THR   B O    1 
ATOM   4719 C  CB   . THR   B 2 330 ? -1.97330  -16.58228 -23.43721 1.000 23.54179 ? 1382 THR   B CB   1 
ATOM   4720 O  OG1  . THR   B 2 330 ? -3.15741  -15.99853 -22.87116 1.000 26.83722 ? 1382 THR   B OG1  1 
ATOM   4721 C  CG2  . THR   B 2 330 ? -1.68817  -17.94737 -22.80945 1.000 24.33244 ? 1382 THR   B CG2  1 
ATOM   4722 N  N    . VAL   B 2 331 ? -0.41342  -14.71771 -25.45477 1.000 22.12379 ? 1383 VAL   B N    1 
ATOM   4723 C  CA   . VAL   B 2 331 ? -0.66647  -13.82553 -26.57562 1.000 24.79706 ? 1383 VAL   B CA   1 
ATOM   4724 C  C    . VAL   B 2 331 ? -1.32931  -14.64240 -27.67081 1.000 29.09089 ? 1383 VAL   B C    1 
ATOM   4725 O  O    . VAL   B 2 331 ? -1.25516  -15.87439 -27.69204 1.000 26.48744 ? 1383 VAL   B O    1 
ATOM   4726 C  CB   . VAL   B 2 331 ? 0.61148   -13.15027 -27.10842 1.000 24.46974 ? 1383 VAL   B CB   1 
ATOM   4727 C  CG1  . VAL   B 2 331 ? 1.31032   -12.38140 -25.99224 1.000 26.00535 ? 1383 VAL   B CG1  1 
ATOM   4728 C  CG2  . VAL   B 2 331 ? 1.53964   -14.19005 -27.69957 1.000 27.39901 ? 1383 VAL   B CG2  1 
ATOM   4729 N  N    . CYS   B 2 332 ? -1.99135  -13.93531 -28.57471 1.000 26.89014 ? 1384 CYS   B N    1 
ATOM   4730 C  CA   . CYS   B 2 332 ? -2.50221  -14.49914 -29.81284 1.000 24.08329 ? 1384 CYS   B CA   1 
ATOM   4731 C  C    . CYS   B 2 332 ? -1.59820  -14.04982 -30.94971 1.000 28.66971 ? 1384 CYS   B C    1 
ATOM   4732 O  O    . CYS   B 2 332 ? -1.41034  -12.84576 -31.15447 1.000 26.83638 ? 1384 CYS   B O    1 
ATOM   4733 C  CB   . CYS   B 2 332 ? -3.93725  -14.04827 -30.07384 1.000 23.79748 ? 1384 CYS   B CB   1 
ATOM   4734 S  SG   . CYS   B 2 332 ? -4.54609  -14.64804 -31.65798 1.000 26.93447 ? 1384 CYS   B SG   1 
ATOM   4735 N  N    . ARG   B 2 333 ? -1.03105  -15.01361 -31.67086 1.000 22.90070 ? 1385 ARG   B N    1 
ATOM   4736 C  CA   . ARG   B 2 333 ? -0.23901  -14.74929 -32.86277 1.000 30.02235 ? 1385 ARG   B CA   1 
ATOM   4737 C  C    . ARG   B 2 333 ? -1.04190  -15.16516 -34.08389 1.000 31.29741 ? 1385 ARG   B C    1 
ATOM   4738 O  O    . ARG   B 2 333 ? -1.61776  -16.26222 -34.11813 1.000 30.17999 ? 1385 ARG   B O    1 
ATOM   4739 C  CB   . ARG   B 2 333 ? 1.10607   -15.48813 -32.83283 1.000 29.70222 ? 1385 ARG   B CB   1 
ATOM   4740 C  CG   . ARG   B 2 333 ? 2.22794   -14.69913 -32.13262 1.000 36.43060 ? 1385 ARG   B CG   1 
ATOM   4741 C  CD   . ARG   B 2 333 ? 3.65502   -15.20089 -32.46164 1.000 31.45149 ? 1385 ARG   B CD   1 
ATOM   4742 N  NE   . ARG   B 2 333 ? 4.62687   -14.19785 -32.03740 1.000 43.14297 ? 1385 ARG   B NE   1 
ATOM   4743 C  CZ   . ARG   B 2 333 ? 4.84677   -13.89007 -30.76533 1.000 48.49641 ? 1385 ARG   B CZ   1 
ATOM   4744 N  NH1  . ARG   B 2 333 ? 4.25779   -14.55532 -29.77949 1.000 47.43055 ? 1385 ARG   B NH1  1 
ATOM   4745 N  NH2  . ARG   B 2 333 ? 5.66363   -12.88102 -30.47009 1.000 35.97499 ? 1385 ARG   B NH2  1 
ATOM   4746 N  N    . LEU   B 2 334 ? -1.08695  -14.27898 -35.06872 1.000 25.08667 ? 1386 LEU   B N    1 
ATOM   4747 C  CA   . LEU   B 2 334 ? -1.70585  -14.54281 -36.35481 1.000 29.01984 ? 1386 LEU   B CA   1 
ATOM   4748 C  C    . LEU   B 2 334 ? -0.61076  -14.82248 -37.37280 1.000 31.30755 ? 1386 LEU   B C    1 
ATOM   4749 O  O    . LEU   B 2 334 ? 0.31015   -14.01534 -37.53960 1.000 28.58304 ? 1386 LEU   B O    1 
ATOM   4750 C  CB   . LEU   B 2 334 ? -2.54597  -13.35383 -36.79663 1.000 30.62434 ? 1386 LEU   B CB   1 
ATOM   4751 C  CG   . LEU   B 2 334 ? -3.38088  -13.56469 -38.04771 1.000 31.89181 ? 1386 LEU   B CG   1 
ATOM   4752 C  CD1  . LEU   B 2 334 ? -4.55778  -14.49689 -37.75695 1.000 29.33857 ? 1386 LEU   B CD1  1 
ATOM   4753 C  CD2  . LEU   B 2 334 ? -3.84901  -12.20565 -38.55648 1.000 31.66208 ? 1386 LEU   B CD2  1 
ATOM   4754 N  N    . TYR   B 2 335 ? -0.70258  -15.97237 -38.03202 1.000 25.33050 ? 1387 TYR   B N    1 
ATOM   4755 C  CA   . TYR   B 2 335 ? 0.27652   -16.40007 -39.00905 1.000 29.20117 ? 1387 TYR   B CA   1 
ATOM   4756 C  C    . TYR   B 2 335 ? -0.37739  -16.47889 -40.37810 1.000 35.78359 ? 1387 TYR   B C    1 
ATOM   4757 O  O    . TYR   B 2 335 ? -1.56135  -16.80901 -40.51023 1.000 30.29836 ? 1387 TYR   B O    1 
ATOM   4758 C  CB   . TYR   B 2 335 ? 0.87167   -17.76006 -38.66228 1.000 29.78666 ? 1387 TYR   B CB   1 
ATOM   4759 C  CG   . TYR   B 2 335 ? 1.60160   -17.80222 -37.35724 1.000 32.57217 ? 1387 TYR   B CG   1 
ATOM   4760 C  CD1  . TYR   B 2 335 ? 2.92154   -17.36807 -37.26409 1.000 30.91916 ? 1387 TYR   B CD1  1 
ATOM   4761 C  CD2  . TYR   B 2 335 ? 0.98360   -18.29351 -36.21137 1.000 27.64945 ? 1387 TYR   B CD2  1 
ATOM   4762 C  CE1  . TYR   B 2 335 ? 3.60649   -17.42122 -36.06006 1.000 35.42130 ? 1387 TYR   B CE1  1 
ATOM   4763 C  CE2  . TYR   B 2 335 ? 1.65454   -18.33966 -34.99734 1.000 29.88592 ? 1387 TYR   B CE2  1 
ATOM   4764 C  CZ   . TYR   B 2 335 ? 2.96948   -17.90851 -34.92419 1.000 33.01154 ? 1387 TYR   B CZ   1 
ATOM   4765 O  OH   . TYR   B 2 335 ? 3.64942   -17.95565 -33.72116 1.000 27.36628 ? 1387 TYR   B OH   1 
ATOM   4766 N  N    . GLU   B 2 336 ? 0.41062   -16.15860 -41.39000 1.000 34.87683 ? 1388 GLU   B N    1 
ATOM   4767 C  CA   . GLU   B 2 336 ? -0.03728  -16.32940 -42.75706 1.000 38.73462 ? 1388 GLU   B CA   1 
ATOM   4768 C  C    . GLU   B 2 336 ? 0.21391   -17.76629 -43.18131 1.000 34.99382 ? 1388 GLU   B C    1 
ATOM   4769 O  O    . GLU   B 2 336 ? 1.31397   -18.29519 -42.98935 1.000 35.03769 ? 1388 GLU   B O    1 
ATOM   4770 C  CB   . GLU   B 2 336 ? 0.69265   -15.35313 -43.66883 1.000 41.20585 ? 1388 GLU   B CB   1 
ATOM   4771 C  CG   . GLU   B 2 336 ? 0.18372   -15.30893 -45.08285 1.000 48.47972 ? 1388 GLU   B CG   1 
ATOM   4772 C  CD   . GLU   B 2 336 ? 0.97464   -14.31668 -45.90462 1.000 56.31281 ? 1388 GLU   B CD   1 
ATOM   4773 O  OE1  . GLU   B 2 336 ? 2.07671   -14.68646 -46.36763 1.000 52.13119 ? 1388 GLU   B OE1  1 
ATOM   4774 O  OE2  . GLU   B 2 336 ? 0.51451   -13.16171 -46.04643 1.000 60.47059 ? 1388 GLU   B OE2  1 
ATOM   4775 N  N    . VAL   B 2 337 ? -0.81798  -18.41131 -43.70949 1.000 35.94142 ? 1389 VAL   B N    1 
ATOM   4776 C  CA   . VAL   B 2 337 ? -0.67179  -19.75719 -44.24074 1.000 43.06650 ? 1389 VAL   B CA   1 
ATOM   4777 C  C    . VAL   B 2 337 ? -0.18572  -19.65086 -45.69269 1.000 46.70454 ? 1389 VAL   B C    1 
ATOM   4778 O  O    . VAL   B 2 337 ? -0.93572  -19.27778 -46.59466 1.000 47.19328 ? 1389 VAL   B O    1 
ATOM   4779 C  CB   . VAL   B 2 337 ? -1.98369  -20.54737 -44.14996 1.000 40.93803 ? 1389 VAL   B CB   1 
ATOM   4780 C  CG1  . VAL   B 2 337 ? -1.75350  -21.99627 -44.53022 1.000 48.61632 ? 1389 VAL   B CG1  1 
ATOM   4781 C  CG2  . VAL   B 2 337 ? -2.55678  -20.45870 -42.75297 1.000 38.70987 ? 1389 VAL   B CG2  1 
ATOM   4782 N  N    . GLY   B 2 338 ? 1.06534   -20.00166 -45.93969 1.000 46.64999 ? 1390 GLY   B N    1 
ATOM   4783 C  CA   . GLY   B 2 338 ? 1.59742   -20.07534 -47.29467 1.000 59.37479 ? 1390 GLY   B CA   1 
ATOM   4784 C  C    . GLY   B 2 338 ? 1.07461   -21.30727 -48.02594 1.000 75.17354 ? 1390 GLY   B C    1 
ATOM   4785 O  O    . GLY   B 2 338 ? 0.76770   -22.31641 -47.43414 1.000 68.86092 ? 1390 GLY   B O    1 
ATOM   4786 O  OXT  . GLY   B 2 338 ? 0.95068   -21.30805 -49.25094 1.000 91.86806 ? 1390 GLY   B OXT  1 
HETATM 4787 C  C18  . A1ANN C 3 .   ? -6.23826  -23.09341 -9.62467  1.000 61.14062 ? 1401 A1ANN A C18  1 
HETATM 4788 C  C19  . A1ANN C 3 .   ? -7.82123  -23.17455 -9.91477  1.000 70.61895 ? 1401 A1ANN A C19  1 
HETATM 4789 C  C21  . A1ANN C 3 .   ? -8.58443  -22.56605 -7.73470  1.000 50.73336 ? 1401 A1ANN A C21  1 
HETATM 4790 C  C22  . A1ANN C 3 .   ? -9.97747  -22.03814 -8.17267  1.000 55.97379 ? 1401 A1ANN A C22  1 
HETATM 4791 C  C01  . A1ANN C 3 .   ? -7.93508  -27.59742 -21.27661 1.000 36.47642 ? 1401 A1ANN A C01  1 
HETATM 4792 C  C03  . A1ANN C 3 .   ? -7.91129  -26.88487 -18.89048 1.000 40.05741 ? 1401 A1ANN A C03  1 
HETATM 4793 C  C04  . A1ANN C 3 .   ? -6.64538  -26.55086 -18.09735 1.000 41.86552 ? 1401 A1ANN A C04  1 
HETATM 4794 C  C06  . A1ANN C 3 .   ? -4.92759  -24.94969 -17.86895 1.000 52.15950 ? 1401 A1ANN A C06  1 
HETATM 4795 C  C07  . A1ANN C 3 .   ? -4.34871  -23.64152 -18.43667 1.000 43.41944 ? 1401 A1ANN A C07  1 
HETATM 4796 C  C09  . A1ANN C 3 .   ? -6.06493  -22.02880 -18.03546 1.000 57.85760 ? 1401 A1ANN A C09  1 
HETATM 4797 C  C10  . A1ANN C 3 .   ? -6.39413  -20.85302 -17.10625 1.000 51.31920 ? 1401 A1ANN A C10  1 
HETATM 4798 C  C12  . A1ANN C 3 .   ? -6.74430  -20.48350 -14.77620 1.000 55.82644 ? 1401 A1ANN A C12  1 
HETATM 4799 C  C13  . A1ANN C 3 .   ? -7.23228  -21.22280 -13.50537 1.000 64.26193 ? 1401 A1ANN A C13  1 
HETATM 4800 C  C15  . A1ANN C 3 .   ? -5.12718  -22.22363 -13.05644 1.000 70.76337 ? 1401 A1ANN A C15  1 
HETATM 4801 C  C16  . A1ANN C 3 .   ? -4.96427  -22.14791 -11.48542 1.000 67.47810 ? 1401 A1ANN A C16  1 
HETATM 4802 C  C24  . A1ANN C 3 .   ? -11.57824 -24.10643 -7.66915  1.000 38.83051 ? 1401 A1ANN A C24  1 
HETATM 4803 C  C26  . A1ANN C 3 .   ? -12.62427 -24.40376 -6.58926  1.000 32.26678 ? 1401 A1ANN A C26  1 
HETATM 4804 C  C27  . A1ANN C 3 .   ? -13.96624 -24.48287 -6.90835  1.000 25.79982 ? 1401 A1ANN A C27  1 
HETATM 4805 C  C28  . A1ANN C 3 .   ? -14.87027 -24.70017 -5.88344  1.000 24.95494 ? 1401 A1ANN A C28  1 
HETATM 4806 C  C29  . A1ANN C 3 .   ? -14.43833 -24.80737 -4.57544  1.000 18.35021 ? 1401 A1ANN A C29  1 
HETATM 4807 C  C31  . A1ANN C 3 .   ? -13.08535 -24.70826 -4.26435  1.000 20.40479 ? 1401 A1ANN A C31  1 
HETATM 4808 C  C32  . A1ANN C 3 .   ? -12.57741 -24.80744 -2.98334  1.000 21.12148 ? 1401 A1ANN A C32  1 
HETATM 4809 C  C33  . A1ANN C 3 .   ? -13.16455 -24.20872 -1.88426  1.000 22.23740 ? 1401 A1ANN A C33  1 
HETATM 4810 C  C34  . A1ANN C 3 .   ? -11.41634 -25.52033 -2.80141  1.000 19.52954 ? 1401 A1ANN A C34  1 
HETATM 4811 C  C35  . A1ANN C 3 .   ? -10.84039 -25.63150 -1.54940  1.000 20.33769 ? 1401 A1ANN A C35  1 
HETATM 4812 C  C37  . A1ANN C 3 .   ? -8.40230  -26.12410 -2.09136  1.000 22.25927 ? 1401 A1ANN A C37  1 
HETATM 4813 C  C39  . A1ANN C 3 .   ? -7.32717  -27.20499 -1.97551  1.000 20.45510 ? 1401 A1ANN A C39  1 
HETATM 4814 C  C40  . A1ANN C 3 .   ? -5.97521  -26.99087 -1.72339  1.000 24.37329 ? 1401 A1ANN A C40  1 
HETATM 4815 C  C41  . A1ANN C 3 .   ? -5.11408  -28.08678 -1.66755  1.000 24.43105 ? 1401 A1ANN A C41  1 
HETATM 4816 C  C42  . A1ANN C 3 .   ? -5.59092  -29.37880 -1.87682  1.000 26.64384 ? 1401 A1ANN A C42  1 
HETATM 4817 C  C44  . A1ANN C 3 .   ? -6.93588  -29.58691 -2.14093  1.000 25.93235 ? 1401 A1ANN A C44  1 
HETATM 4818 C  C45  . A1ANN C 3 .   ? -7.79201  -28.49501 -2.18977  1.000 23.61387 ? 1401 A1ANN A C45  1 
HETATM 4819 C  C46  . A1ANN C 3 .   ? -5.42740  -25.56185 -1.48409  1.000 24.73818 ? 1401 A1ANN A C46  1 
HETATM 4820 C  C50  . A1ANN C 3 .   ? -11.43852 -25.05778 -0.44532  1.000 20.23958 ? 1401 A1ANN A C50  1 
HETATM 4821 C  C52  . A1ANN C 3 .   ? -11.53368 -24.89927 2.07470   1.000 18.06940 ? 1401 A1ANN A C52  1 
HETATM 4822 C  C53  . A1ANN C 3 .   ? -10.65872 -25.13140 3.34971   1.000 17.53258 ? 1401 A1ANN A C53  1 
HETATM 4823 C  C54  . A1ANN C 3 .   ? -11.55083 -24.80275 4.61572   1.000 19.87457 ? 1401 A1ANN A C54  1 
HETATM 4824 C  C56  . A1ANN C 3 .   ? -8.81384  -24.60738 4.40890   1.000 21.23655 ? 1401 A1ANN A C56  1 
HETATM 4825 C  C57  . A1ANN C 3 .   ? -8.76573  -24.53096 2.22492   1.000 20.19623 ? 1401 A1ANN A C57  1 
HETATM 4826 C  C58  . A1ANN C 3 .   ? -7.64886  -23.41681 2.15619   1.000 17.45818 ? 1401 A1ANN A C58  1 
HETATM 4827 C  C59  . A1ANN C 3 .   ? -9.59368  -24.38581 0.92390   1.000 18.64786 ? 1401 A1ANN A C59  1 
HETATM 4828 C  C60  . A1ANN C 3 .   ? -12.59760 -24.32589 -0.62125  1.000 16.94358 ? 1401 A1ANN A C60  1 
HETATM 4829 C  C61  . A1ANN C 3 .   ? -12.18433 -24.49096 -5.28126  1.000 24.13150 ? 1401 A1ANN A C61  1 
HETATM 4830 C  C63  . A1ANN C 3 .   ? -7.53607  -27.10412 -22.58850 1.000 34.95676 ? 1401 A1ANN A C63  1 
HETATM 4831 C  C64  . A1ANN C 3 .   ? -8.13495  -27.54699 -23.66561 1.000 25.84496 ? 1401 A1ANN A C64  1 
HETATM 4832 C  C65  . A1ANN C 3 .   ? -8.12689  -27.38270 -25.18258 1.000 26.54809 ? 1401 A1ANN A C65  1 
HETATM 4833 C  C67  . A1ANN C 3 .   ? -7.92292  -26.32333 -27.04437 1.000 26.05811 ? 1401 A1ANN A C67  1 
HETATM 4834 C  C68  . A1ANN C 3 .   ? -8.19774  -27.64430 -27.35764 1.000 25.86114 ? 1401 A1ANN A C68  1 
HETATM 4835 C  C69  . A1ANN C 3 .   ? -8.29260  -28.18704 -28.78374 1.000 28.54224 ? 1401 A1ANN A C69  1 
HETATM 4836 C  C72  . A1ANN C 3 .   ? -8.18351  -27.80957 -31.19767 1.000 31.50350 ? 1401 A1ANN A C72  1 
HETATM 4837 C  C73  . A1ANN C 3 .   ? -6.76447  -27.97731 -31.69462 1.000 32.20454 ? 1401 A1ANN A C73  1 
HETATM 4838 C  C74  . A1ANN C 3 .   ? -5.72158  -27.33530 -31.02944 1.000 29.29295 ? 1401 A1ANN A C74  1 
HETATM 4839 C  C75  . A1ANN C 3 .   ? -4.43054  -27.49106 -31.48440 1.000 25.61842 ? 1401 A1ANN A C75  1 
HETATM 4840 C  C77  . A1ANN C 3 .   ? -4.18338  -28.28282 -32.59854 1.000 26.46786 ? 1401 A1ANN A C77  1 
HETATM 4841 C  C79  . A1ANN C 3 .   ? -5.22327  -28.91382 -33.25571 1.000 26.58363 ? 1401 A1ANN A C79  1 
HETATM 4842 C  C80  . A1ANN C 3 .   ? -6.51931  -28.76607 -32.80276 1.000 27.56579 ? 1401 A1ANN A C80  1 
HETATM 4843 C  C81  . A1ANN C 3 .   ? -8.92358  -26.82950 -32.08452 1.000 35.93801 ? 1401 A1ANN A C81  1 
HETATM 4844 C  C82  . A1ANN C 3 .   ? -10.40262 -26.67974 -31.72957 1.000 43.10668 ? 1401 A1ANN A C82  1 
HETATM 4845 C  C85  . A1ANN C 3 .   ? -8.31672  -28.33854 -26.16577 1.000 26.40177 ? 1401 A1ANN A C85  1 
HETATM 4846 C  C86  . A1ANN C 3 .   ? -8.58357  -29.68660 -26.01204 1.000 24.44195 ? 1401 A1ANN A C86  1 
HETATM 4847 C  C87  . A1ANN C 3 .   ? -7.60749  -30.51758 -25.49815 1.000 22.33630 ? 1401 A1ANN A C87  1 
HETATM 4848 C  C88  . A1ANN C 3 .   ? -7.85834  -31.86964 -25.34742 1.000 24.59491 ? 1401 A1ANN A C88  1 
HETATM 4849 C  C89  . A1ANN C 3 .   ? -9.08825  -32.39772 -25.71558 1.000 29.81753 ? 1401 A1ANN A C89  1 
HETATM 4850 C  C91  . A1ANN C 3 .   ? -10.06332 -31.56974 -26.23648 1.000 24.41544 ? 1401 A1ANN A C91  1 
HETATM 4851 C  C92  . A1ANN C 3 .   ? -9.81648  -30.21868 -26.39221 1.000 25.60658 ? 1401 A1ANN A C92  1 
HETATM 4852 F  F30  . A1ANN C 3 .   ? -15.34935 -25.01966 -3.59553  1.000 22.68442 ? 1401 A1ANN A F30  1 
HETATM 4853 F  F43  . A1ANN C 3 .   ? -4.76179  -30.44671 -1.82798  1.000 25.76798 ? 1401 A1ANN A F43  1 
HETATM 4854 F  F47  . A1ANN C 3 .   ? -4.16142  -25.61879 -0.99503  1.000 23.85136 ? 1401 A1ANN A F47  1 
HETATM 4855 F  F48  . A1ANN C 3 .   ? -6.24253  -24.94912 -0.59002  1.000 26.00459 ? 1401 A1ANN A F48  1 
HETATM 4856 F  F49  . A1ANN C 3 .   ? -5.42842  -24.86463 -2.65096  1.000 25.11439 ? 1401 A1ANN A F49  1 
HETATM 4857 F  F78  . A1ANN C 3 .   ? -2.92134  -28.43758 -33.05650 1.000 33.25624 ? 1401 A1ANN A F78  1 
HETATM 4858 F  F93  . A1ANN C 3 .   ? -10.78955 -29.42570 -26.91111 1.000 25.83190 ? 1401 A1ANN A F93  1 
HETATM 4859 N  N02  . A1ANN C 3 .   ? -7.64424  -26.72156 -20.31143 1.000 37.89361 ? 1401 A1ANN A N02  1 
HETATM 4860 N  N23  . A1ANN C 3 .   ? -11.00742 -22.77441 -7.41887  1.000 45.90616 ? 1401 A1ANN A N23  1 
HETATM 4861 N  N36  . A1ANN C 3 .   ? -9.65529  -26.45637 -1.48049  1.000 20.51082 ? 1401 A1ANN A N36  1 
HETATM 4862 N  N51  . A1ANN C 3 .   ? -10.80158 -25.17595 0.84369   1.000 18.59965 ? 1401 A1ANN A N51  1 
HETATM 4863 N  N55  . A1ANN C 3 .   ? -9.52781  -24.36127 3.36591   1.000 20.09854 ? 1401 A1ANN A N55  1 
HETATM 4864 N  N66  . A1ANN C 3 .   ? -7.89000  -26.21057 -25.74235 1.000 24.22470 ? 1401 A1ANN A N66  1 
HETATM 4865 N  N71  . A1ANN C 3 .   ? -8.12865  -27.25882 -29.86556 1.000 32.55898 ? 1401 A1ANN A N71  1 
HETATM 4866 N  N84  . A1ANN C 3 .   ? -10.94380 -25.35385 -31.48835 1.000 43.42189 ? 1401 A1ANN A N84  1 
HETATM 4867 O  O05  . A1ANN C 3 .   ? -6.14551  -25.28772 -18.52408 1.000 55.95826 ? 1401 A1ANN A O05  1 
HETATM 4868 O  O08  . A1ANN C 3 .   ? -4.76989  -22.50371 -17.69948 1.000 60.14455 ? 1401 A1ANN A O08  1 
HETATM 4869 O  O11  . A1ANN C 3 .   ? -6.82913  -21.38430 -15.86538 1.000 53.35255 ? 1401 A1ANN A O11  1 
HETATM 4870 O  O14  . A1ANN C 3 .   ? -6.49314  -22.41874 -13.35756 1.000 72.27568 ? 1401 A1ANN A O14  1 
HETATM 4871 O  O17  . A1ANN C 3 .   ? -5.55816  -23.35209 -10.89168 1.000 65.97805 ? 1401 A1ANN A O17  1 
HETATM 4872 O  O20  . A1ANN C 3 .   ? -8.47724  -23.63886 -8.70389  1.000 62.16141 ? 1401 A1ANN A O20  1 
HETATM 4873 O  O25  . A1ANN C 3 .   ? -11.32211 -24.82623 -8.56327  1.000 36.28344 ? 1401 A1ANN A O25  1 
HETATM 4874 O  O38  . A1ANN C 3 .   ? -8.25739  -25.11897 -2.68516  1.000 20.07641 ? 1401 A1ANN A O38  1 
HETATM 4875 O  O62  . A1ANN C 3 .   ? -8.44696  -28.68552 -21.08185 1.000 39.32393 ? 1401 A1ANN A O62  1 
HETATM 4876 O  O70  . A1ANN C 3 .   ? -8.44945  -29.32202 -29.01897 1.000 27.13734 ? 1401 A1ANN A O70  1 
HETATM 4877 O  O83  . A1ANN C 3 .   ? -11.08551 -27.63984 -31.63379 1.000 50.14846 ? 1401 A1ANN A O83  1 
HETATM 4878 CL CL76 . A1ANN C 3 .   ? -3.09068  -26.67806 -30.64918 1.000 29.96968 ? 1401 A1ANN A CL76 1 
HETATM 4879 CL CL90 . A1ANN C 3 .   ? -9.42005  -34.14079 -25.52993 1.000 31.35033 ? 1401 A1ANN A CL90 1 
HETATM 4880 O  O    . HOH   D 4 .   ? -8.32500  -11.44000 -9.32200  1.000 49.52492 ? 1501 HOH   A O    1 
HETATM 4881 O  O    . HOH   D 4 .   ? -22.95600 -36.39000 -0.54300  1.000 39.35292 ? 1502 HOH   A O    1 
HETATM 4882 O  O    . HOH   D 4 .   ? -26.45800 -7.51300  16.67200  1.000 51.94998 ? 1503 HOH   A O    1 
HETATM 4883 O  O    . HOH   D 4 .   ? -15.86700 0.87100   7.06500   1.000 51.85094 ? 1504 HOH   A O    1 
HETATM 4884 O  O    . HOH   D 4 .   ? -19.86400 -40.50800 17.65700  1.000 35.63720 ? 1505 HOH   A O    1 
HETATM 4885 O  O    . HOH   D 4 .   ? -24.22000 -41.49800 2.67200   1.000 52.32912 ? 1506 HOH   A O    1 
HETATM 4886 O  O    . HOH   D 4 .   ? 12.21900  -27.03000 21.33100  1.000 31.70250 ? 1507 HOH   A O    1 
HETATM 4887 O  O    . HOH   D 4 .   ? -0.27200  -25.05000 25.36700  1.000 29.23370 ? 1508 HOH   A O    1 
HETATM 4888 O  O    . HOH   D 4 .   ? 10.60400  -25.90000 11.89200  1.000 37.09006 ? 1509 HOH   A O    1 
HETATM 4889 O  O    . HOH   D 4 .   ? -17.46600 -24.84000 22.12000  1.000 42.68310 ? 1510 HOH   A O    1 
HETATM 4890 O  O    . HOH   D 4 .   ? 9.948     -32.770   2.939     1.000 28.06123 ? 1511 HOH   A O    1 
HETATM 4891 O  O    . HOH   D 4 .   ? 7.850     -7.910    20.621    1.000 46.18880 ? 1512 HOH   A O    1 
HETATM 4892 O  O    . HOH   D 4 .   ? -12.54700 -19.56100 -7.42500  1.000 23.80164 ? 1513 HOH   A O    1 
HETATM 4893 O  O    . HOH   D 4 .   ? -21.12000 -35.58400 -7.67200  1.000 39.30213 ? 1514 HOH   A O    1 
HETATM 4894 O  O    . HOH   D 4 .   ? 2.840     -15.873   24.737    1.000 32.34376 ? 1515 HOH   A O    1 
HETATM 4895 O  O    . HOH   D 4 .   ? -2.74100  -37.13500 21.69800  1.000 46.88505 ? 1516 HOH   A O    1 
HETATM 4896 O  O    . HOH   D 4 .   ? -14.36000 -1.07400  3.06800   1.000 40.90549 ? 1517 HOH   A O    1 
HETATM 4897 O  O    . HOH   D 4 .   ? -14.48500 -18.22800 15.90200  1.000 40.53692 ? 1518 HOH   A O    1 
HETATM 4898 O  O    . HOH   D 4 .   ? -5.21700  -33.68600 -5.13100  1.000 37.76764 ? 1519 HOH   A O    1 
HETATM 4899 O  O    . HOH   D 4 .   ? -10.50400 -5.55700  -0.30300  1.000 32.44804 ? 1520 HOH   A O    1 
HETATM 4900 O  O    . HOH   D 4 .   ? -8.19600  -10.27400 24.80000  1.000 45.38263 ? 1521 HOH   A O    1 
HETATM 4901 O  O    . HOH   D 4 .   ? 8.18200   -37.31100 7.68400   1.000 43.58374 ? 1522 HOH   A O    1 
HETATM 4902 O  O    . HOH   D 4 .   ? -26.01400 -21.99700 -8.20100  1.000 26.48082 ? 1523 HOH   A O    1 
HETATM 4903 O  O    . HOH   D 4 .   ? -15.09100 -5.53900  -4.19600  1.000 47.72473 ? 1524 HOH   A O    1 
HETATM 4904 O  O    . HOH   D 4 .   ? -14.38100 -1.47300  5.55500   1.000 38.72416 ? 1525 HOH   A O    1 
HETATM 4905 O  O    . HOH   D 4 .   ? -20.26500 -22.71600 -9.61000  1.000 41.97353 ? 1526 HOH   A O    1 
HETATM 4906 O  O    . HOH   D 4 .   ? -21.84500 -43.06300 3.24500   1.000 37.17514 ? 1527 HOH   A O    1 
HETATM 4907 O  O    . HOH   D 4 .   ? 7.45200   -35.63700 4.41100   1.000 36.77967 ? 1528 HOH   A O    1 
HETATM 4908 O  O    . HOH   D 4 .   ? 5.69500   -20.34800 17.75400  1.000 26.73052 ? 1529 HOH   A O    1 
HETATM 4909 O  O    . HOH   D 4 .   ? -26.89200 -13.60300 15.75800  1.000 40.92077 ? 1530 HOH   A O    1 
HETATM 4910 O  O    . HOH   D 4 .   ? -2.81700  -22.92900 25.36100  1.000 34.58115 ? 1531 HOH   A O    1 
HETATM 4911 O  O    . HOH   D 4 .   ? -19.42500 -8.09400  -5.16600  1.000 40.74263 ? 1532 HOH   A O    1 
HETATM 4912 O  O    . HOH   D 4 .   ? 1.36500   -28.86500 -8.88600  1.000 68.26587 ? 1533 HOH   A O    1 
HETATM 4913 O  O    . HOH   D 4 .   ? -12.28300 -26.20400 8.92400   1.000 21.15621 ? 1534 HOH   A O    1 
HETATM 4914 O  O    . HOH   D 4 .   ? 4.87900   -11.57600 1.50000   1.000 24.07369 ? 1535 HOH   A O    1 
HETATM 4915 O  O    . HOH   D 4 .   ? 5.84500   -14.24200 -5.21100  1.000 22.48873 ? 1536 HOH   A O    1 
HETATM 4916 O  O    . HOH   D 4 .   ? 5.79100   -10.89500 21.50700  1.000 34.90404 ? 1537 HOH   A O    1 
HETATM 4917 O  O    . HOH   D 4 .   ? -10.38100 -0.88500  1.33600   1.000 44.58767 ? 1538 HOH   A O    1 
HETATM 4918 O  O    . HOH   D 4 .   ? 5.62600   -34.08100 0.86900   1.000 32.29129 ? 1539 HOH   A O    1 
HETATM 4919 O  O    . HOH   D 4 .   ? 4.43300   -27.97400 22.07000  1.000 37.31740 ? 1540 HOH   A O    1 
HETATM 4920 O  O    . HOH   D 4 .   ? -11.04400 -26.19000 12.62700  1.000 26.41387 ? 1541 HOH   A O    1 
HETATM 4921 O  O    . HOH   D 4 .   ? -17.53000 -12.46600 19.44400  1.000 48.39558 ? 1542 HOH   A O    1 
HETATM 4922 O  O    . HOH   D 4 .   ? -32.834   -27.179   17.842    1.000 43.75694 ? 1543 HOH   A O    1 
HETATM 4923 O  O    . HOH   D 4 .   ? -9.96700  -31.38100 -1.25500  1.000 28.65853 ? 1544 HOH   A O    1 
HETATM 4924 O  O    . HOH   D 4 .   ? 3.15300   -13.01000 4.17300   1.000 25.02840 ? 1545 HOH   A O    1 
HETATM 4925 O  O    . HOH   D 4 .   ? -4.44300  -15.88000 19.22400  1.000 25.11308 ? 1546 HOH   A O    1 
HETATM 4926 O  O    . HOH   D 4 .   ? -28.204   -21.873   -3.965    1.000 20.21084 ? 1547 HOH   A O    1 
HETATM 4927 O  O    . HOH   D 4 .   ? -9.45200  -17.84100 16.68800  1.000 38.30030 ? 1548 HOH   A O    1 
HETATM 4928 O  O    . HOH   D 4 .   ? 8.11400   -26.81500 2.49800   1.000 29.32565 ? 1549 HOH   A O    1 
HETATM 4929 O  O    . HOH   D 4 .   ? -37.51900 -26.47500 7.17800   1.000 48.57722 ? 1550 HOH   A O    1 
HETATM 4930 O  O    . HOH   D 4 .   ? -13.36900 -42.68600 15.46000  1.000 32.42436 ? 1551 HOH   A O    1 
HETATM 4931 O  O    . HOH   D 4 .   ? -11.80300 -16.46900 1.24000   1.000 19.03344 ? 1552 HOH   A O    1 
HETATM 4932 O  O    . HOH   D 4 .   ? -22.59900 -13.70800 -1.63800  1.000 24.41499 ? 1553 HOH   A O    1 
HETATM 4933 O  O    . HOH   D 4 .   ? -7.26700  -23.27000 7.33100   1.000 20.49177 ? 1554 HOH   A O    1 
HETATM 4934 O  O    . HOH   D 4 .   ? -23.38500 -31.02500 17.94800  1.000 25.32275 ? 1555 HOH   A O    1 
HETATM 4935 O  O    . HOH   D 4 .   ? 11.59800  -17.76400 9.66300   1.000 26.74943 ? 1556 HOH   A O    1 
HETATM 4936 O  O    . HOH   D 4 .   ? -26.64400 -27.96600 -8.60400  1.000 34.83833 ? 1557 HOH   A O    1 
HETATM 4937 O  O    . HOH   D 4 .   ? 9.06800   -19.15700 3.38600   1.000 27.35625 ? 1558 HOH   A O    1 
HETATM 4938 O  O    . HOH   D 4 .   ? -34.96400 -27.80900 13.37300  1.000 43.66202 ? 1559 HOH   A O    1 
HETATM 4939 O  O    . HOH   D 4 .   ? 9.92900   -14.79500 5.26000   1.000 32.53848 ? 1560 HOH   A O    1 
HETATM 4940 O  O    . HOH   D 4 .   ? -3.94100  -14.31000 17.01800  1.000 26.02206 ? 1561 HOH   A O    1 
HETATM 4941 O  O    . HOH   D 4 .   ? -7.16100  -21.82300 17.27400  1.000 38.11864 ? 1562 HOH   A O    1 
HETATM 4942 O  O    . HOH   D 4 .   ? -5.57500  -11.04500 19.84000  1.000 25.00751 ? 1563 HOH   A O    1 
HETATM 4943 O  O    . HOH   D 4 .   ? -16.67100 -14.00900 20.11500  1.000 42.15287 ? 1564 HOH   A O    1 
HETATM 4944 O  O    . HOH   D 4 .   ? 7.84700   -30.93900 18.20700  1.000 35.04640 ? 1565 HOH   A O    1 
HETATM 4945 O  O    . HOH   D 4 .   ? -3.14500  -10.41600 18.82500  1.000 29.10215 ? 1566 HOH   A O    1 
HETATM 4946 O  O    . HOH   D 4 .   ? -13.41900 -36.57400 -8.59300  1.000 43.90699 ? 1567 HOH   A O    1 
HETATM 4947 O  O    . HOH   D 4 .   ? 3.93800   -17.03900 -6.17700  1.000 28.86637 ? 1568 HOH   A O    1 
HETATM 4948 O  O    . HOH   D 4 .   ? -22.70600 -17.00800 -6.64100  1.000 29.80891 ? 1569 HOH   A O    1 
HETATM 4949 O  O    . HOH   D 4 .   ? -0.07000  -17.81400 -7.27000  1.000 36.95859 ? 1570 HOH   A O    1 
HETATM 4950 O  O    . HOH   D 4 .   ? 9.628     -29.396   -3.987    1.000 30.19322 ? 1571 HOH   A O    1 
HETATM 4951 O  O    . HOH   D 4 .   ? -11.25400 -12.89100 2.46000   1.000 37.50491 ? 1572 HOH   A O    1 
HETATM 4952 O  O    . HOH   D 4 .   ? -16.69300 -40.78400 -0.58000  1.000 29.12703 ? 1573 HOH   A O    1 
HETATM 4953 O  O    . HOH   D 4 .   ? 11.068    -11.571   14.675    1.000 29.54094 ? 1574 HOH   A O    1 
HETATM 4954 O  O    . HOH   D 4 .   ? 0.37900   -42.09300 9.57100   1.000 34.28158 ? 1575 HOH   A O    1 
HETATM 4955 O  O    . HOH   D 4 .   ? -18.16100 -44.15200 6.00800   1.000 39.74293 ? 1576 HOH   A O    1 
HETATM 4956 O  O    . HOH   D 4 .   ? -22.21300 -43.55400 18.02900  1.000 33.40564 ? 1577 HOH   A O    1 
HETATM 4957 O  O    . HOH   D 4 .   ? -10.99300 -21.49500 -5.01800  1.000 28.93880 ? 1578 HOH   A O    1 
HETATM 4958 O  O    . HOH   D 4 .   ? -1.05800  -39.77600 2.19300   1.000 25.36011 ? 1579 HOH   A O    1 
HETATM 4959 O  O    . HOH   D 4 .   ? 5.64300   -33.93000 -3.87700  1.000 41.03479 ? 1580 HOH   A O    1 
HETATM 4960 O  O    . HOH   D 4 .   ? -20.50700 -29.01100 -8.32700  1.000 24.47092 ? 1581 HOH   A O    1 
HETATM 4961 O  O    . HOH   D 4 .   ? -0.11000  -21.21700 -6.42900  1.000 33.77049 ? 1582 HOH   A O    1 
HETATM 4962 O  O    . HOH   D 4 .   ? 0.86500   -14.72600 -5.48400  1.000 34.97459 ? 1583 HOH   A O    1 
HETATM 4963 O  O    . HOH   D 4 .   ? 5.42600   -11.99000 -2.08800  1.000 31.66847 ? 1584 HOH   A O    1 
HETATM 4964 O  O    . HOH   D 4 .   ? -3.93800  -38.97100 20.13000  1.000 35.18715 ? 1585 HOH   A O    1 
HETATM 4965 O  O    . HOH   D 4 .   ? -9.85000  -26.08100 -10.50600 1.000 50.39277 ? 1586 HOH   A O    1 
HETATM 4966 O  O    . HOH   D 4 .   ? -23.08200 -20.59900 -9.93400  1.000 37.27313 ? 1587 HOH   A O    1 
HETATM 4967 O  O    . HOH   D 4 .   ? -10.47800 -21.79800 3.59400   1.000 19.11980 ? 1588 HOH   A O    1 
HETATM 4968 O  O    . HOH   D 4 .   ? -7.75800  0.26200   6.77200   1.000 37.97261 ? 1589 HOH   A O    1 
HETATM 4969 O  O    . HOH   D 4 .   ? -11.72800 -17.61400 14.87300  1.000 28.44464 ? 1590 HOH   A O    1 
HETATM 4970 O  O    . HOH   D 4 .   ? -5.19700  -24.12600 25.42800  1.000 29.32705 ? 1591 HOH   A O    1 
HETATM 4971 O  O    . HOH   D 4 .   ? 6.608     -24.727   -6.440    1.000 26.85142 ? 1592 HOH   A O    1 
HETATM 4972 O  O    . HOH   D 4 .   ? 6.70300   -38.86000 11.22300  1.000 35.87993 ? 1593 HOH   A O    1 
HETATM 4973 O  O    . HOH   D 4 .   ? -11.69100 -2.31700  5.96700   1.000 29.35432 ? 1594 HOH   A O    1 
HETATM 4974 O  O    . HOH   D 4 .   ? -10.01200 -37.04700 26.20900  1.000 37.82504 ? 1595 HOH   A O    1 
HETATM 4975 O  O    . HOH   D 4 .   ? -14.14900 -13.71800 -8.09000  1.000 45.01110 ? 1596 HOH   A O    1 
HETATM 4976 O  O    . HOH   D 4 .   ? -7.62100  -30.23600 24.19700  1.000 32.36276 ? 1597 HOH   A O    1 
HETATM 4977 O  O    . HOH   D 4 .   ? -13.08800 -21.88500 3.22700   1.000 17.55087 ? 1598 HOH   A O    1 
HETATM 4978 O  O    . HOH   D 4 .   ? -11.70500 -4.29600  17.89400  1.000 34.34267 ? 1599 HOH   A O    1 
HETATM 4979 O  O    . HOH   D 4 .   ? -7.30100  -15.69600 19.36400  1.000 27.19959 ? 1600 HOH   A O    1 
HETATM 4980 O  O    . HOH   D 4 .   ? -31.72000 -31.18900 5.20500   1.000 31.85387 ? 1601 HOH   A O    1 
HETATM 4981 O  O    . HOH   D 4 .   ? -7.84300  -19.76900 14.61500  1.000 29.25510 ? 1602 HOH   A O    1 
HETATM 4982 O  O    . HOH   D 4 .   ? -24.60000 -19.75300 18.36300  1.000 44.74465 ? 1603 HOH   A O    1 
HETATM 4983 O  O    . HOH   D 4 .   ? 10.238    -15.884   2.059     1.000 31.85825 ? 1604 HOH   A O    1 
HETATM 4984 O  O    . HOH   D 4 .   ? -27.692   -19.244   -4.955    1.000 22.78184 ? 1605 HOH   A O    1 
HETATM 4985 O  O    . HOH   D 4 .   ? -16.88700 -38.75400 1.91300   1.000 24.20982 ? 1606 HOH   A O    1 
HETATM 4986 O  O    . HOH   D 4 .   ? -14.96100 -22.63900 9.04200   1.000 22.75896 ? 1607 HOH   A O    1 
HETATM 4987 O  O    . HOH   D 4 .   ? 13.33400  -19.43900 13.21900  1.000 31.45468 ? 1608 HOH   A O    1 
HETATM 4988 O  O    . HOH   D 4 .   ? -3.30500  -45.59200 9.38300   1.000 36.81781 ? 1609 HOH   A O    1 
HETATM 4989 O  O    . HOH   D 4 .   ? -12.95000 -29.16300 14.80600  1.000 27.10064 ? 1610 HOH   A O    1 
HETATM 4990 O  O    . HOH   D 4 .   ? -16.71100 -26.81000 14.49900  1.000 25.73043 ? 1611 HOH   A O    1 
HETATM 4991 O  O    . HOH   D 4 .   ? 12.73300  -22.53000 7.44900   1.000 26.03442 ? 1612 HOH   A O    1 
HETATM 4992 O  O    . HOH   D 4 .   ? -7.04100  -22.22500 9.97500   1.000 21.06883 ? 1613 HOH   A O    1 
HETATM 4993 O  O    . HOH   D 4 .   ? -7.99000  -25.57200 15.68400  1.000 31.75693 ? 1614 HOH   A O    1 
HETATM 4994 O  O    . HOH   D 4 .   ? -11.09300 -37.65200 -6.82100  1.000 34.97631 ? 1615 HOH   A O    1 
HETATM 4995 O  O    . HOH   D 4 .   ? 11.68900  -28.80000 12.56400  1.000 34.39648 ? 1616 HOH   A O    1 
HETATM 4996 O  O    . HOH   D 4 .   ? -7.09500  -24.16500 -21.32400 1.000 31.99615 ? 1617 HOH   A O    1 
HETATM 4997 O  O    . HOH   D 4 .   ? -26.80700 -29.93700 -5.38900  1.000 27.83329 ? 1618 HOH   A O    1 
HETATM 4998 O  O    . HOH   D 4 .   ? 2.15500   -17.45400 28.27400  1.000 39.89000 ? 1619 HOH   A O    1 
HETATM 4999 O  O    . HOH   D 4 .   ? -10.23300 -0.14900  19.02500  1.000 47.43970 ? 1620 HOH   A O    1 
HETATM 5000 O  O    . HOH   D 4 .   ? -25.33600 -17.54000 -7.88300  1.000 41.63244 ? 1621 HOH   A O    1 
HETATM 5001 O  O    . HOH   D 4 .   ? -7.34800  -24.99900 -5.34600  1.000 39.20841 ? 1622 HOH   A O    1 
HETATM 5002 O  O    . HOH   D 4 .   ? -24.23200 -14.25300 1.21100   1.000 38.50422 ? 1623 HOH   A O    1 
HETATM 5003 O  O    . HOH   D 4 .   ? -19.22900 -20.42300 18.11000  1.000 32.41856 ? 1624 HOH   A O    1 
HETATM 5004 O  O    . HOH   D 4 .   ? -27.43800 -6.42600  6.35000   1.000 39.78727 ? 1625 HOH   A O    1 
HETATM 5005 O  O    . HOH   D 4 .   ? -13.69100 -23.54900 11.24100  1.000 30.25954 ? 1626 HOH   A O    1 
HETATM 5006 O  O    . HOH   D 4 .   ? 8.55600   -9.96600  11.06900  1.000 33.64600 ? 1627 HOH   A O    1 
HETATM 5007 O  O    . HOH   D 4 .   ? -8.82300  -24.01500 23.23400  1.000 34.23873 ? 1628 HOH   A O    1 
HETATM 5008 O  O    . HOH   D 4 .   ? 5.76600   -26.85900 4.87000   1.000 24.65365 ? 1629 HOH   A O    1 
HETATM 5009 O  O    . HOH   D 4 .   ? -25.88300 -14.33600 -9.08400  1.000 52.87922 ? 1630 HOH   A O    1 
HETATM 5010 O  O    . HOH   D 4 .   ? 6.03200   -27.70100 -6.80300  1.000 34.39224 ? 1631 HOH   A O    1 
HETATM 5011 O  O    . HOH   D 4 .   ? -9.17400  -27.52000 14.24000  1.000 22.37332 ? 1632 HOH   A O    1 
HETATM 5012 O  O    . HOH   D 4 .   ? -2.99300  -38.40600 4.53500   1.000 28.64789 ? 1633 HOH   A O    1 
HETATM 5013 O  O    . HOH   D 4 .   ? -3.51600  -41.65500 -5.87500  1.000 51.31542 ? 1634 HOH   A O    1 
HETATM 5014 O  O    . HOH   D 4 .   ? -12.79800 -41.92300 18.01900  1.000 41.70143 ? 1635 HOH   A O    1 
HETATM 5015 O  O    . HOH   D 4 .   ? -10.01000 -46.74000 7.34700   1.000 33.42550 ? 1636 HOH   A O    1 
HETATM 5016 O  O    . HOH   D 4 .   ? -19.51700 -33.31200 -8.29400  1.000 32.89070 ? 1637 HOH   A O    1 
HETATM 5017 O  O    . HOH   D 4 .   ? 12.22800  -32.18200 14.63100  1.000 36.90602 ? 1638 HOH   A O    1 
HETATM 5018 O  O    . HOH   D 4 .   ? -4.39900  -32.12100 26.26900  1.000 45.03407 ? 1639 HOH   A O    1 
HETATM 5019 O  O    . HOH   D 4 .   ? -26.970   -34.874   13.637    1.000 38.38973 ? 1640 HOH   A O    1 
HETATM 5020 O  O    . HOH   D 4 .   ? -19.83800 -9.35600  -0.40600  1.000 34.74398 ? 1641 HOH   A O    1 
HETATM 5021 O  O    . HOH   D 4 .   ? 12.61000  -20.54300 10.84100  1.000 32.86716 ? 1642 HOH   A O    1 
HETATM 5022 O  O    . HOH   D 4 .   ? -18.32200 -11.19700 2.74800   1.000 21.48511 ? 1643 HOH   A O    1 
HETATM 5023 O  O    . HOH   D 4 .   ? 0.91600   -13.79400 23.95000  1.000 29.07147 ? 1644 HOH   A O    1 
HETATM 5024 O  O    . HOH   D 4 .   ? -21.11600 -19.37700 -8.69300  1.000 37.91439 ? 1645 HOH   A O    1 
HETATM 5025 O  O    . HOH   D 4 .   ? 11.08600  -26.44400 9.13400   1.000 31.75316 ? 1646 HOH   A O    1 
HETATM 5026 O  O    . HOH   D 4 .   ? -33.70800 -30.34300 16.49600  1.000 34.83793 ? 1647 HOH   A O    1 
HETATM 5027 O  O    . HOH   D 4 .   ? 6.22400   -8.40300  10.77600  1.000 38.37165 ? 1648 HOH   A O    1 
HETATM 5028 O  O    . HOH   D 4 .   ? 0.42000   -44.32700 4.42300   1.000 46.65434 ? 1649 HOH   A O    1 
HETATM 5029 O  O    . HOH   D 4 .   ? -9.40600  -22.37500 -2.94100  1.000 19.48785 ? 1650 HOH   A O    1 
HETATM 5030 O  O    . HOH   D 4 .   ? -1.78600  -14.27600 -6.50100  1.000 39.69872 ? 1651 HOH   A O    1 
HETATM 5031 O  O    . HOH   D 4 .   ? 1.23300   -21.02900 26.53800  1.000 46.01970 ? 1652 HOH   A O    1 
HETATM 5032 O  O    . HOH   D 4 .   ? -3.16900  -44.46700 6.98200   1.000 34.55967 ? 1653 HOH   A O    1 
HETATM 5033 O  O    . HOH   D 4 .   ? -10.74400 -14.73600 4.07800   1.000 26.82248 ? 1654 HOH   A O    1 
HETATM 5034 O  O    . HOH   D 4 .   ? -12.42100 -11.70300 1.04400   1.000 33.86682 ? 1655 HOH   A O    1 
HETATM 5035 O  O    . HOH   D 4 .   ? -10.92000 -35.49400 -10.46800 1.000 50.39302 ? 1656 HOH   A O    1 
HETATM 5036 O  O    . HOH   D 4 .   ? -29.62800 -28.80000 16.86700  1.000 32.39475 ? 1657 HOH   A O    1 
HETATM 5037 O  O    . HOH   D 4 .   ? -14.28700 -10.24700 -7.92700  1.000 43.24188 ? 1658 HOH   A O    1 
HETATM 5038 O  O    . HOH   D 4 .   ? -8.14800  -42.23200 20.16200  1.000 43.52397 ? 1659 HOH   A O    1 
HETATM 5039 O  O    . HOH   D 4 .   ? -14.46300 3.12700   11.42600  1.000 52.25174 ? 1660 HOH   A O    1 
HETATM 5040 O  O    . HOH   D 4 .   ? -5.42300  -44.58900 5.48000   1.000 39.27129 ? 1661 HOH   A O    1 
HETATM 5041 O  O    . HOH   D 4 .   ? -17.69300 -22.44800 17.48700  1.000 33.47509 ? 1662 HOH   A O    1 
HETATM 5042 O  O    . HOH   D 4 .   ? 8.88400   -32.64200 7.25800   1.000 30.36731 ? 1663 HOH   A O    1 
HETATM 5043 O  O    . HOH   D 4 .   ? -11.68600 -10.85400 17.45000  1.000 27.79140 ? 1664 HOH   A O    1 
HETATM 5044 O  O    . HOH   D 4 .   ? -14.46600 -25.05600 7.24900   1.000 23.93131 ? 1665 HOH   A O    1 
HETATM 5045 O  O    . HOH   D 4 .   ? -11.23700 -27.46200 23.73900  1.000 38.60077 ? 1666 HOH   A O    1 
HETATM 5046 O  O    . HOH   D 4 .   ? -10.35800 -38.76500 21.88000  1.000 44.93706 ? 1667 HOH   A O    1 
HETATM 5047 O  O    . HOH   D 4 .   ? -23.80600 -32.94500 -6.96800  1.000 41.55961 ? 1668 HOH   A O    1 
HETATM 5048 O  O    . HOH   D 4 .   ? 1.92800   -3.50400  8.84100   1.000 34.61664 ? 1669 HOH   A O    1 
HETATM 5049 O  O    . HOH   D 4 .   ? -21.56000 -43.90000 5.71100   1.000 43.47840 ? 1670 HOH   A O    1 
HETATM 5050 O  O    . HOH   D 4 .   ? -29.74500 -37.60300 5.03200   1.000 40.65850 ? 1671 HOH   A O    1 
HETATM 5051 O  O    . HOH   D 4 .   ? -12.51500 -34.41700 21.99300  1.000 38.24706 ? 1672 HOH   A O    1 
HETATM 5052 O  O    . HOH   D 4 .   ? -6.57900  -23.10400 14.79200  1.000 26.18731 ? 1673 HOH   A O    1 
HETATM 5053 O  O    . HOH   D 4 .   ? -29.09100 -28.67600 -3.28800  1.000 36.09460 ? 1674 HOH   A O    1 
HETATM 5054 O  O    . HOH   D 4 .   ? -26.84700 -30.13800 -2.76100  1.000 27.59564 ? 1675 HOH   A O    1 
HETATM 5055 O  O    . HOH   D 4 .   ? -23.99500 -44.51200 12.98000  1.000 46.87234 ? 1676 HOH   A O    1 
HETATM 5056 O  O    . HOH   D 4 .   ? -8.72100  -30.60500 -18.80700 1.000 52.92919 ? 1677 HOH   A O    1 
HETATM 5057 O  O    . HOH   D 4 .   ? -35.15100 -15.74200 9.22300   1.000 49.95669 ? 1678 HOH   A O    1 
HETATM 5058 O  O    . HOH   D 4 .   ? -31.20000 -11.11300 5.99800   1.000 45.06895 ? 1679 HOH   A O    1 
HETATM 5059 O  O    . HOH   D 4 .   ? 5.75400   -7.85100  8.24300   1.000 36.52786 ? 1680 HOH   A O    1 
HETATM 5060 O  O    . HOH   D 4 .   ? -3.16700  -43.61500 21.12700  1.000 50.30971 ? 1681 HOH   A O    1 
HETATM 5061 O  O    . HOH   D 4 .   ? 13.06900  -23.87200 17.80300  1.000 38.71064 ? 1682 HOH   A O    1 
HETATM 5062 O  O    . HOH   D 4 .   ? 8.17500   -29.48600 20.37100  1.000 44.05368 ? 1683 HOH   A O    1 
HETATM 5063 O  O    . HOH   D 4 .   ? -13.53000 -46.79600 8.37900   1.000 32.04532 ? 1684 HOH   A O    1 
HETATM 5064 O  O    . HOH   D 4 .   ? -9.11400  -4.32700  20.68100  1.000 36.80614 ? 1685 HOH   A O    1 
HETATM 5065 O  O    . HOH   D 4 .   ? 6.20000   -26.24200 20.96100  1.000 29.90579 ? 1686 HOH   A O    1 
HETATM 5066 O  O    . HOH   D 4 .   ? -2.71600  -32.27700 -5.01900  1.000 36.73812 ? 1687 HOH   A O    1 
HETATM 5067 O  O    . HOH   D 4 .   ? -29.47400 -39.47300 11.49700  1.000 45.69575 ? 1688 HOH   A O    1 
HETATM 5068 O  O    . HOH   D 4 .   ? -19.50800 -0.12200  11.96800  1.000 47.46399 ? 1689 HOH   A O    1 
HETATM 5069 O  O    . HOH   D 4 .   ? -12.12300 -27.78100 -9.23100  1.000 43.39953 ? 1690 HOH   A O    1 
HETATM 5070 O  O    . HOH   D 4 .   ? -14.83000 -33.46200 -10.95900 1.000 41.16490 ? 1691 HOH   A O    1 
HETATM 5071 O  O    . HOH   D 4 .   ? -4.89800  -1.88200  1.51100   1.000 47.02015 ? 1692 HOH   A O    1 
HETATM 5072 O  O    . HOH   D 4 .   ? -1.86300  -33.15400 22.59900  1.000 45.80165 ? 1693 HOH   A O    1 
HETATM 5073 O  O    . HOH   D 4 .   ? -0.85000  -9.07400  -6.15200  1.000 53.07590 ? 1694 HOH   A O    1 
HETATM 5074 O  O    . HOH   D 4 .   ? -19.48600 -1.72700  7.83400   1.000 44.10630 ? 1695 HOH   A O    1 
HETATM 5075 O  O    . HOH   D 4 .   ? -29.68200 -8.41800  3.67200   1.000 48.19063 ? 1696 HOH   A O    1 
HETATM 5076 O  O    . HOH   D 4 .   ? -9.68500  -0.76700  4.78400   1.000 38.66610 ? 1697 HOH   A O    1 
HETATM 5077 O  O    . HOH   D 4 .   ? -27.07900 -39.76700 4.83700   1.000 44.45701 ? 1698 HOH   A O    1 
HETATM 5078 O  O    . HOH   D 4 .   ? 3.71400   -13.10300 -6.33000  1.000 38.00664 ? 1699 HOH   A O    1 
HETATM 5079 O  O    . HOH   D 4 .   ? -31.34300 -33.65400 4.84300   1.000 44.70959 ? 1700 HOH   A O    1 
HETATM 5080 O  O    . HOH   D 4 .   ? -8.13300  -18.69000 18.79400  1.000 46.22455 ? 1701 HOH   A O    1 
HETATM 5081 O  O    . HOH   D 4 .   ? -7.18200  -23.68800 18.85600  1.000 34.13452 ? 1702 HOH   A O    1 
HETATM 5082 O  O    . HOH   D 4 .   ? -1.73600  -27.64000 27.60000  1.000 54.34171 ? 1703 HOH   A O    1 
HETATM 5083 O  O    . HOH   D 4 .   ? -8.02400  -21.90900 12.44900  1.000 25.86643 ? 1704 HOH   A O    1 
HETATM 5084 O  O    . HOH   D 4 .   ? -1.34300  -23.63700 -5.31800  1.000 32.30940 ? 1705 HOH   A O    1 
HETATM 5085 O  O    . HOH   D 4 .   ? -1.22000  -19.36600 -7.26000  1.000 52.58144 ? 1706 HOH   A O    1 
HETATM 5086 O  O    . HOH   D 4 .   ? -16.99900 -12.65000 -7.71100  1.000 46.41099 ? 1707 HOH   A O    1 
HETATM 5087 O  O    . HOH   D 4 .   ? -12.67700 -28.43600 18.40200  1.000 47.37180 ? 1708 HOH   A O    1 
HETATM 5088 O  O    . HOH   D 4 .   ? -7.91000  -36.10700 27.06800  1.000 46.33863 ? 1709 HOH   A O    1 
HETATM 5089 O  O    . HOH   D 4 .   ? 13.132    -15.087   12.500    1.000 40.13635 ? 1710 HOH   A O    1 
HETATM 5090 O  O    . HOH   D 4 .   ? -20.03400 -27.04700 24.34600  1.000 49.42948 ? 1711 HOH   A O    1 
HETATM 5091 O  O    . HOH   D 4 .   ? 5.26300   -9.60700  -0.38400  1.000 36.38515 ? 1712 HOH   A O    1 
HETATM 5092 O  O    . HOH   D 4 .   ? -19.29700 -6.52600  17.63400  1.000 55.76920 ? 1713 HOH   A O    1 
HETATM 5093 O  O    . HOH   D 4 .   ? 10.61500  -31.11000 8.39200   1.000 40.52914 ? 1714 HOH   A O    1 
HETATM 5094 O  O    . HOH   D 4 .   ? 11.72300  -23.96300 12.10200  1.000 45.00571 ? 1715 HOH   A O    1 
HETATM 5095 O  O    . HOH   D 4 .   ? -5.88800  -25.00500 -6.93400  1.000 64.34453 ? 1716 HOH   A O    1 
HETATM 5096 O  O    . HOH   D 4 .   ? -34.15900 -15.91700 14.08000  1.000 52.90924 ? 1717 HOH   A O    1 
HETATM 5097 O  O    . HOH   D 4 .   ? -10.78700 -40.21900 -6.63200  1.000 46.08722 ? 1718 HOH   A O    1 
HETATM 5098 O  O    . HOH   D 4 .   ? -22.20500 -12.02400 -8.33900  1.000 56.46229 ? 1719 HOH   A O    1 
HETATM 5099 O  O    . HOH   D 4 .   ? -12.58500 -40.13900 22.67100  1.000 55.95024 ? 1720 HOH   A O    1 
HETATM 5100 O  O    . HOH   D 4 .   ? -12.52800 -29.55800 -10.81900 1.000 47.12097 ? 1721 HOH   A O    1 
HETATM 5101 O  O    . HOH   D 4 .   ? -7.54500  -27.80800 25.85800  1.000 40.85704 ? 1722 HOH   A O    1 
HETATM 5102 O  O    . HOH   D 4 .   ? 7.11900   -34.77900 2.51500   1.000 46.89417 ? 1723 HOH   A O    1 
HETATM 5103 O  O    . HOH   D 4 .   ? -11.86200 -27.36200 -35.18600 1.000 47.88208 ? 1724 HOH   A O    1 
HETATM 5104 O  O    . HOH   D 4 .   ? -13.93000 -26.48800 -33.64100 1.000 43.10679 ? 1725 HOH   A O    1 
HETATM 5105 O  O    . HOH   D 4 .   ? 11.84000  -29.30800 9.70800   1.000 46.94571 ? 1726 HOH   A O    1 
HETATM 5106 O  O    . HOH   D 4 .   ? -28.55800 -28.67400 -6.83000  1.000 35.15264 ? 1727 HOH   A O    1 
HETATM 5107 O  O    . HOH   D 4 .   ? -19.17400 -42.00900 -4.60600  1.000 49.46514 ? 1728 HOH   A O    1 
HETATM 5108 O  O    . HOH   D 4 .   ? -14.12500 -30.95400 -11.96800 1.000 48.80795 ? 1729 HOH   A O    1 
HETATM 5109 O  O    . HOH   D 4 .   ? 10.036    -10.581   3.972     1.000 40.88910 ? 1730 HOH   A O    1 
HETATM 5110 O  O    . HOH   D 4 .   ? -1.63900  -24.03100 27.75000  1.000 45.67755 ? 1731 HOH   A O    1 
HETATM 5111 O  O    . HOH   D 4 .   ? 9.107     -9.628    21.170    1.000 49.24227 ? 1732 HOH   A O    1 
HETATM 5112 O  O    . HOH   D 4 .   ? -19.86400 -46.32800 2.97300   1.000 53.54195 ? 1733 HOH   A O    1 
HETATM 5113 O  O    . HOH   D 4 .   ? -5.98700  -26.99800 -9.45700  1.000 59.03658 ? 1734 HOH   A O    1 
HETATM 5114 O  O    . HOH   D 4 .   ? -15.45200 -15.74900 -8.41600  1.000 45.50339 ? 1735 HOH   A O    1 
HETATM 5115 O  O    . HOH   D 4 .   ? -13.02900 -45.01700 16.13300  1.000 46.03112 ? 1736 HOH   A O    1 
HETATM 5116 O  O    . HOH   D 4 .   ? 13.75900  -25.89600 19.44800  1.000 39.75749 ? 1737 HOH   A O    1 
HETATM 5117 O  O    . HOH   D 4 .   ? -17.36800 -8.52200  19.54300  1.000 49.35991 ? 1738 HOH   A O    1 
HETATM 5118 O  O    . HOH   D 4 .   ? 7.166     -12.483   -3.555    1.000 26.52171 ? 1739 HOH   A O    1 
HETATM 5119 O  O    . HOH   D 4 .   ? -14.08100 -17.76400 -8.87200  1.000 37.80085 ? 1740 HOH   A O    1 
HETATM 5120 O  O    . HOH   D 4 .   ? 1.65500   -36.57700 20.25900  1.000 53.24467 ? 1741 HOH   A O    1 
HETATM 5121 O  O    . HOH   D 4 .   ? 3.25800   -35.15200 -3.96400  1.000 41.90448 ? 1742 HOH   A O    1 
HETATM 5122 O  O    . HOH   D 4 .   ? -34.50300 -33.06800 16.38500  1.000 47.21481 ? 1743 HOH   A O    1 
HETATM 5123 O  O    . HOH   D 4 .   ? -14.83000 -8.25600  19.95200  1.000 41.33204 ? 1744 HOH   A O    1 
HETATM 5124 O  O    . HOH   D 4 .   ? -10.71900 -42.64500 19.71100  1.000 46.56174 ? 1745 HOH   A O    1 
HETATM 5125 O  O    . HOH   D 4 .   ? 3.04000   -4.04500  2.70900   1.000 45.73004 ? 1746 HOH   A O    1 
HETATM 5126 O  O    . HOH   D 4 .   ? -6.11100  -42.04700 -6.51400  1.000 53.79632 ? 1747 HOH   A O    1 
HETATM 5127 O  O    . HOH   D 4 .   ? 6.82400   -38.67200 4.58100   1.000 38.12829 ? 1748 HOH   A O    1 
HETATM 5128 O  O    . HOH   D 4 .   ? -9.34900  -23.99400 20.21900  1.000 39.55699 ? 1749 HOH   A O    1 
HETATM 5129 O  O    . HOH   D 4 .   ? -16.41500 -11.49500 18.14400  1.000 38.31270 ? 1750 HOH   A O    1 
HETATM 5130 O  O    . HOH   D 4 .   ? -29.075   -6.355    -8.169    1.000 51.06042 ? 1751 HOH   A O    1 
HETATM 5131 O  O    . HOH   D 4 .   ? 1.36400   -40.51000 0.92300   1.000 31.94239 ? 1752 HOH   A O    1 
HETATM 5132 O  O    . HOH   D 4 .   ? -18.04000 -6.36900  -6.71400  1.000 49.08612 ? 1753 HOH   A O    1 
HETATM 5133 O  O    . HOH   D 4 .   ? -3.95700  -24.73400 -5.72800  1.000 49.83864 ? 1754 HOH   A O    1 
HETATM 5134 O  O    . HOH   D 4 .   ? -9.81400  -21.73000 16.34400  1.000 50.72201 ? 1755 HOH   A O    1 
HETATM 5135 O  O    . HOH   D 4 .   ? 0.14900   -50.06400 20.29000  1.000 63.71981 ? 1756 HOH   A O    1 
HETATM 5136 O  O    . HOH   D 4 .   ? -14.00000 -11.02500 19.12700  1.000 35.24806 ? 1757 HOH   A O    1 
HETATM 5137 O  O    . HOH   D 4 .   ? -30.35300 0.99600   -0.10000  1.000 66.92410 ? 1758 HOH   A O    1 
HETATM 5138 O  O    . HOH   E 4 .   ? -35.297   -42.360   -43.843   1.000 59.13039 ? 1401 HOH   B O    1 
HETATM 5139 O  O    . HOH   E 4 .   ? -31.67400 -15.90100 -27.64400 1.000 53.14432 ? 1402 HOH   B O    1 
HETATM 5140 O  O    . HOH   E 4 .   ? -35.91600 -22.12800 -31.05800 1.000 56.36493 ? 1403 HOH   B O    1 
HETATM 5141 O  O    . HOH   E 4 .   ? -15.01700 -52.89300 -23.52100 1.000 46.74541 ? 1404 HOH   B O    1 
HETATM 5142 O  O    . HOH   E 4 .   ? -7.77400  -53.74000 -33.55600 1.000 37.33751 ? 1405 HOH   B O    1 
HETATM 5143 O  O    . HOH   E 4 .   ? -14.21300 -28.16800 -20.39200 1.000 36.78168 ? 1406 HOH   B O    1 
HETATM 5144 O  O    . HOH   E 4 .   ? -16.42600 -27.28900 -26.15900 1.000 40.57518 ? 1407 HOH   B O    1 
HETATM 5145 O  O    . HOH   E 4 .   ? 2.48800   -40.58300 -50.54200 1.000 57.16276 ? 1408 HOH   B O    1 
HETATM 5146 O  O    . HOH   E 4 .   ? -8.95500  -51.26700 -45.79900 1.000 33.09354 ? 1409 HOH   B O    1 
HETATM 5147 O  O    . HOH   E 4 .   ? -25.66500 -51.01300 -29.46100 1.000 39.05377 ? 1410 HOH   B O    1 
HETATM 5148 O  O    . HOH   E 4 .   ? -32.69400 -28.07200 -34.19700 1.000 43.11541 ? 1411 HOH   B O    1 
HETATM 5149 O  O    . HOH   E 4 .   ? -13.91400 -40.68600 -19.86800 1.000 38.34387 ? 1412 HOH   B O    1 
HETATM 5150 O  O    . HOH   E 4 .   ? -6.76000  -40.11200 -46.07800 1.000 35.88948 ? 1413 HOH   B O    1 
HETATM 5151 O  O    . HOH   E 4 .   ? -4.32000  -9.73700  -15.27000 1.000 48.19919 ? 1414 HOH   B O    1 
HETATM 5152 O  O    . HOH   E 4 .   ? -19.25500 -33.20600 -15.94500 1.000 27.19511 ? 1415 HOH   B O    1 
HETATM 5153 O  O    . HOH   E 4 .   ? 6.412     -10.954   -40.060   1.000 37.40237 ? 1416 HOH   B O    1 
HETATM 5154 O  O    . HOH   E 4 .   ? -9.02400  -1.90100  -34.68200 1.000 37.07733 ? 1417 HOH   B O    1 
HETATM 5155 O  O    . HOH   E 4 .   ? -31.59300 -42.94700 -43.38100 1.000 51.98519 ? 1418 HOH   B O    1 
HETATM 5156 O  O    . HOH   E 4 .   ? -23.01400 -20.93200 -13.19000 1.000 47.34906 ? 1419 HOH   B O    1 
HETATM 5157 O  O    . HOH   E 4 .   ? -10.40200 -46.97700 -29.86400 1.000 25.54463 ? 1420 HOH   B O    1 
HETATM 5158 O  O    . HOH   E 4 .   ? -26.03200 -29.71300 -10.86700 1.000 48.40708 ? 1421 HOH   B O    1 
HETATM 5159 O  O    . HOH   E 4 .   ? -14.00100 -43.91800 -17.67400 1.000 49.21510 ? 1422 HOH   B O    1 
HETATM 5160 O  O    . HOH   E 4 .   ? -0.86600  -48.31500 -35.80900 1.000 28.03652 ? 1423 HOH   B O    1 
HETATM 5161 O  O    . HOH   E 4 .   ? -5.038    -2.619    -16.265   1.000 62.04797 ? 1424 HOH   B O    1 
HETATM 5162 O  O    . HOH   E 4 .   ? -10.48500 -12.17500 -18.96600 1.000 31.58052 ? 1425 HOH   B O    1 
HETATM 5163 O  O    . HOH   E 4 .   ? -18.72900 -29.50600 -35.58800 1.000 29.09386 ? 1426 HOH   B O    1 
HETATM 5164 O  O    . HOH   E 4 .   ? -8.01700  -44.83100 -20.15200 1.000 29.11472 ? 1427 HOH   B O    1 
HETATM 5165 O  O    . HOH   E 4 .   ? -16.30700 -27.91100 -30.94600 1.000 37.06299 ? 1428 HOH   B O    1 
HETATM 5166 O  O    . HOH   E 4 .   ? -12.80600 -36.68700 -30.69900 1.000 31.45377 ? 1429 HOH   B O    1 
HETATM 5167 O  O    . HOH   E 4 .   ? -27.68200 -33.07400 -38.67800 1.000 47.79081 ? 1430 HOH   B O    1 
HETATM 5168 O  O    . HOH   E 4 .   ? -14.03400 -39.92400 -30.04800 1.000 29.25269 ? 1431 HOH   B O    1 
HETATM 5169 O  O    . HOH   E 4 .   ? -14.77200 -4.85000  -24.71700 1.000 37.17472 ? 1432 HOH   B O    1 
HETATM 5170 O  O    . HOH   E 4 .   ? -27.50900 -24.23200 -16.64600 1.000 33.28222 ? 1433 HOH   B O    1 
HETATM 5171 O  O    . HOH   E 4 .   ? -13.21500 -34.03100 -31.36100 1.000 25.06064 ? 1434 HOH   B O    1 
HETATM 5172 O  O    . HOH   E 4 .   ? -2.62100  -45.44900 -29.92400 1.000 25.28273 ? 1435 HOH   B O    1 
HETATM 5173 O  O    . HOH   E 4 .   ? -15.79200 -51.77300 -20.81100 1.000 49.40493 ? 1436 HOH   B O    1 
HETATM 5174 O  O    . HOH   E 4 .   ? -18.94200 -16.05000 -35.85700 1.000 40.25002 ? 1437 HOH   B O    1 
HETATM 5175 O  O    . HOH   E 4 .   ? -22.91800 -19.81000 -17.67700 1.000 33.62231 ? 1438 HOH   B O    1 
HETATM 5176 O  O    . HOH   E 4 .   ? -2.42500  -31.58900 -21.64400 1.000 38.72780 ? 1439 HOH   B O    1 
HETATM 5177 O  O    . HOH   E 4 .   ? -8.57000  -3.91500  -39.22000 1.000 57.81555 ? 1440 HOH   B O    1 
HETATM 5178 O  O    . HOH   E 4 .   ? -16.01600 -33.17900 -44.68300 1.000 36.76064 ? 1441 HOH   B O    1 
HETATM 5179 O  O    . HOH   E 4 .   ? -4.70000  -24.25400 -43.50700 1.000 40.10250 ? 1442 HOH   B O    1 
HETATM 5180 O  O    . HOH   E 4 .   ? -17.60700 -29.76400 -12.60000 1.000 32.34375 ? 1443 HOH   B O    1 
HETATM 5181 O  O    . HOH   E 4 .   ? -11.42300 -23.63100 -29.17000 1.000 28.55187 ? 1444 HOH   B O    1 
HETATM 5182 O  O    . HOH   E 4 .   ? 4.582     -45.291   -39.736   1.000 37.38844 ? 1445 HOH   B O    1 
HETATM 5183 O  O    . HOH   E 4 .   ? -9.01100  -47.77500 -48.31100 1.000 39.41586 ? 1446 HOH   B O    1 
HETATM 5184 O  O    . HOH   E 4 .   ? -3.89900  -34.22300 -49.45300 1.000 49.99846 ? 1447 HOH   B O    1 
HETATM 5185 O  O    . HOH   E 4 .   ? 2.86800   -36.76500 -30.78200 1.000 30.64433 ? 1448 HOH   B O    1 
HETATM 5186 O  O    . HOH   E 4 .   ? -18.81200 -33.99700 -27.65300 1.000 21.48253 ? 1449 HOH   B O    1 
HETATM 5187 O  O    . HOH   E 4 .   ? 2.92400   -31.20700 -31.01300 1.000 41.70755 ? 1450 HOH   B O    1 
HETATM 5188 O  O    . HOH   E 4 .   ? -10.51200 -30.02200 -34.23100 1.000 44.88574 ? 1451 HOH   B O    1 
HETATM 5189 O  O    . HOH   E 4 .   ? -5.95700  -46.14700 -31.58700 1.000 24.58568 ? 1452 HOH   B O    1 
HETATM 5190 O  O    . HOH   E 4 .   ? -13.10200 -6.46600  -21.07200 1.000 44.35033 ? 1453 HOH   B O    1 
HETATM 5191 O  O    . HOH   E 4 .   ? -14.36000 -37.33400 -21.61900 1.000 28.45191 ? 1454 HOH   B O    1 
HETATM 5192 O  O    . HOH   E 4 .   ? -17.95100 -45.28100 -23.38900 1.000 26.27316 ? 1455 HOH   B O    1 
HETATM 5193 O  O    . HOH   E 4 .   ? -13.06200 -34.20400 -37.83900 1.000 40.33952 ? 1456 HOH   B O    1 
HETATM 5194 O  O    . HOH   E 4 .   ? -4.867    -5.837    -26.829   1.000 30.67664 ? 1457 HOH   B O    1 
HETATM 5195 O  O    . HOH   E 4 .   ? -27.48300 -43.02200 -38.75400 1.000 36.28912 ? 1458 HOH   B O    1 
HETATM 5196 O  O    . HOH   E 4 .   ? -23.93200 -14.80100 -18.51800 1.000 45.06369 ? 1459 HOH   B O    1 
HETATM 5197 O  O    . HOH   E 4 .   ? -24.19400 -22.93000 -39.14100 1.000 31.25061 ? 1460 HOH   B O    1 
HETATM 5198 O  O    . HOH   E 4 .   ? -33.51300 -20.67000 -25.84600 1.000 37.32331 ? 1461 HOH   B O    1 
HETATM 5199 O  O    . HOH   E 4 .   ? -18.23500 -48.09100 -41.20100 1.000 34.14253 ? 1462 HOH   B O    1 
HETATM 5200 O  O    . HOH   E 4 .   ? -19.36300 -33.15300 -34.31000 1.000 24.60571 ? 1463 HOH   B O    1 
HETATM 5201 O  O    . HOH   E 4 .   ? -14.48400 -40.22100 -41.71200 1.000 38.04547 ? 1464 HOH   B O    1 
HETATM 5202 O  O    . HOH   E 4 .   ? -20.78900 -25.67800 -10.57500 1.000 32.05927 ? 1465 HOH   B O    1 
HETATM 5203 O  O    . HOH   E 4 .   ? -6.29200  -45.93000 -28.89700 1.000 23.32657 ? 1466 HOH   B O    1 
HETATM 5204 O  O    . HOH   E 4 .   ? -7.90000  -3.18700  -27.04100 1.000 38.57974 ? 1467 HOH   B O    1 
HETATM 5205 O  O    . HOH   E 4 .   ? -8.13800  -47.63100 -32.00500 1.000 28.50149 ? 1468 HOH   B O    1 
HETATM 5206 O  O    . HOH   E 4 .   ? -26.19600 -26.23500 -15.15100 1.000 37.04260 ? 1469 HOH   B O    1 
HETATM 5207 O  O    . HOH   E 4 .   ? -25.64400 -9.17900  -24.23000 1.000 51.56673 ? 1470 HOH   B O    1 
HETATM 5208 O  O    . HOH   E 4 .   ? -18.29900 -41.64000 -17.69100 1.000 30.05713 ? 1471 HOH   B O    1 
HETATM 5209 O  O    . HOH   E 4 .   ? 5.93100   -13.56000 -27.28700 1.000 40.66797 ? 1472 HOH   B O    1 
HETATM 5210 O  O    . HOH   E 4 .   ? -6.97800  -38.93900 -32.86800 1.000 22.43744 ? 1473 HOH   B O    1 
HETATM 5211 O  O    . HOH   E 4 .   ? 0.86300   -36.06400 -23.71100 1.000 41.40242 ? 1474 HOH   B O    1 
HETATM 5212 O  O    . HOH   E 4 .   ? -19.36600 -45.27400 -26.77000 1.000 26.81910 ? 1475 HOH   B O    1 
HETATM 5213 O  O    . HOH   E 4 .   ? -16.65900 -19.01100 -9.84700  1.000 34.51462 ? 1476 HOH   B O    1 
HETATM 5214 O  O    . HOH   E 4 .   ? -2.506    -47.885   -46.398   1.000 36.06921 ? 1477 HOH   B O    1 
HETATM 5215 O  O    . HOH   E 4 .   ? -10.08200 -37.76100 -27.42800 1.000 26.07838 ? 1478 HOH   B O    1 
HETATM 5216 O  O    . HOH   E 4 .   ? -19.10400 -25.04100 -36.82700 1.000 30.60389 ? 1479 HOH   B O    1 
HETATM 5217 O  O    . HOH   E 4 .   ? -28.24400 -39.28200 -20.13400 1.000 43.24610 ? 1480 HOH   B O    1 
HETATM 5218 O  O    . HOH   E 4 .   ? -19.59300 -38.88200 -44.23100 1.000 36.79083 ? 1481 HOH   B O    1 
HETATM 5219 O  O    . HOH   E 4 .   ? 1.400     -46.362   -42.017   1.000 35.40675 ? 1482 HOH   B O    1 
HETATM 5220 O  O    . HOH   E 4 .   ? -7.75600  -23.98400 -23.90500 1.000 25.56351 ? 1483 HOH   B O    1 
HETATM 5221 O  O    . HOH   E 4 .   ? -1.47400  -43.44500 -23.67000 1.000 32.01954 ? 1484 HOH   B O    1 
HETATM 5222 O  O    . HOH   E 4 .   ? -15.83400 -26.58700 -36.29200 1.000 37.50923 ? 1485 HOH   B O    1 
HETATM 5223 O  O    . HOH   E 4 .   ? -21.36100 -21.65100 -11.83600 1.000 42.28503 ? 1486 HOH   B O    1 
HETATM 5224 O  O    . HOH   E 4 .   ? -14.66900 -35.92100 -35.97000 1.000 24.97769 ? 1487 HOH   B O    1 
HETATM 5225 O  O    . HOH   E 4 .   ? -25.39900 -32.27800 -18.99000 1.000 33.87996 ? 1488 HOH   B O    1 
HETATM 5226 O  O    . HOH   E 4 .   ? -19.95800 -22.28000 -16.08100 1.000 25.61344 ? 1489 HOH   B O    1 
HETATM 5227 O  O    . HOH   E 4 .   ? -31.43200 -22.14900 -30.03300 1.000 35.59039 ? 1490 HOH   B O    1 
HETATM 5228 O  O    . HOH   E 4 .   ? -10.94400 -52.36300 -35.67900 1.000 39.05441 ? 1491 HOH   B O    1 
HETATM 5229 O  O    . HOH   E 4 .   ? -36.20800 -22.32500 -28.38000 1.000 51.81446 ? 1492 HOH   B O    1 
HETATM 5230 O  O    . HOH   E 4 .   ? -11.58600 -2.88300  -35.25600 1.000 43.44362 ? 1493 HOH   B O    1 
HETATM 5231 O  O    . HOH   E 4 .   ? -12.84500 -36.78500 -19.62000 1.000 42.35448 ? 1494 HOH   B O    1 
HETATM 5232 O  O    . HOH   E 4 .   ? -35.95700 -35.90400 -26.41700 1.000 43.22919 ? 1495 HOH   B O    1 
HETATM 5233 O  O    . HOH   E 4 .   ? -1.80200  -36.81900 -23.04600 1.000 38.11433 ? 1496 HOH   B O    1 
HETATM 5234 O  O    . HOH   E 4 .   ? 4.64800   -40.06000 -37.60500 1.000 32.39140 ? 1497 HOH   B O    1 
HETATM 5235 O  O    . HOH   E 4 .   ? -19.92400 -31.78700 -43.31500 1.000 40.33047 ? 1498 HOH   B O    1 
HETATM 5236 O  O    . HOH   E 4 .   ? -14.79600 -32.71900 -34.86400 1.000 26.72051 ? 1499 HOH   B O    1 
HETATM 5237 O  O    . HOH   E 4 .   ? 2.03400   -41.00600 -24.74800 1.000 43.48254 ? 1500 HOH   B O    1 
HETATM 5238 O  O    . HOH   E 4 .   ? -9.55600  -24.99400 -34.52600 1.000 37.64413 ? 1501 HOH   B O    1 
HETATM 5239 O  O    . HOH   E 4 .   ? -8.57700  -33.84400 -32.35600 1.000 24.00674 ? 1502 HOH   B O    1 
HETATM 5240 O  O    . HOH   E 4 .   ? 2.66700   -29.62600 -28.62400 1.000 37.42075 ? 1503 HOH   B O    1 
HETATM 5241 O  O    . HOH   E 4 .   ? 5.28000   -21.28800 -22.54000 1.000 41.53996 ? 1504 HOH   B O    1 
HETATM 5242 O  O    . HOH   E 4 .   ? -11.16200 -29.97600 -38.96600 1.000 32.90950 ? 1505 HOH   B O    1 
HETATM 5243 O  O    . HOH   E 4 .   ? -6.86700  -49.41300 -20.05600 1.000 44.12600 ? 1506 HOH   B O    1 
HETATM 5244 O  O    . HOH   E 4 .   ? -18.87500 -5.73200  -24.80900 1.000 42.16060 ? 1507 HOH   B O    1 
HETATM 5245 O  O    . HOH   E 4 .   ? -26.03800 -39.47200 -18.87100 1.000 35.73277 ? 1508 HOH   B O    1 
HETATM 5246 O  O    . HOH   E 4 .   ? -10.64100 -49.70100 -20.47500 1.000 48.97877 ? 1509 HOH   B O    1 
HETATM 5247 O  O    . HOH   E 4 .   ? -19.57700 -47.00400 -24.72200 1.000 27.62614 ? 1510 HOH   B O    1 
HETATM 5248 O  O    . HOH   E 4 .   ? -11.82000 -20.44300 -36.75300 1.000 30.63002 ? 1511 HOH   B O    1 
HETATM 5249 O  O    . HOH   E 4 .   ? -5.13300  -6.61700  -43.59900 1.000 58.93530 ? 1512 HOH   B O    1 
HETATM 5250 O  O    . HOH   E 4 .   ? -8.75300  -22.78900 -19.71400 1.000 31.52723 ? 1513 HOH   B O    1 
HETATM 5251 O  O    . HOH   E 4 .   ? -20.04200 -39.78300 -17.04100 1.000 44.89884 ? 1514 HOH   B O    1 
HETATM 5252 O  O    . HOH   E 4 .   ? -16.96000 -36.15400 -46.91900 1.000 35.93302 ? 1515 HOH   B O    1 
HETATM 5253 O  O    . HOH   E 4 .   ? -12.05000 -30.26600 -43.81800 1.000 36.62487 ? 1516 HOH   B O    1 
HETATM 5254 O  O    . HOH   E 4 .   ? -26.43100 -26.01100 -41.23900 1.000 40.42705 ? 1517 HOH   B O    1 
HETATM 5255 O  O    . HOH   E 4 .   ? -26.81700 -45.81300 -25.43500 1.000 35.23623 ? 1518 HOH   B O    1 
HETATM 5256 O  O    . HOH   E 4 .   ? -31.07300 -42.19000 -25.69200 1.000 38.55580 ? 1519 HOH   B O    1 
HETATM 5257 O  O    . HOH   E 4 .   ? 11.505    -19.628   -19.300   1.000 48.08738 ? 1520 HOH   B O    1 
HETATM 5258 O  O    . HOH   E 4 .   ? -20.92600 -18.24900 -35.25600 1.000 42.35098 ? 1521 HOH   B O    1 
HETATM 5259 O  O    . HOH   E 4 .   ? 6.80600   -28.99200 -26.59700 1.000 46.12331 ? 1522 HOH   B O    1 
HETATM 5260 O  O    . HOH   E 4 .   ? -10.92300 -18.69300 -13.05400 1.000 52.99908 ? 1523 HOH   B O    1 
HETATM 5261 O  O    . HOH   E 4 .   ? -12.98100 -13.32400 -39.06100 1.000 45.44270 ? 1524 HOH   B O    1 
HETATM 5262 O  O    . HOH   E 4 .   ? -4.39000  -38.17900 -32.43500 1.000 32.34786 ? 1525 HOH   B O    1 
HETATM 5263 O  O    . HOH   E 4 .   ? -8.60100  -13.01700 -18.34500 1.000 39.15767 ? 1526 HOH   B O    1 
HETATM 5264 O  O    . HOH   E 4 .   ? -9.25200  -52.92100 -26.68300 1.000 38.16275 ? 1527 HOH   B O    1 
HETATM 5265 O  O    . HOH   E 4 .   ? -13.37300 -18.96500 -11.38400 1.000 45.73652 ? 1528 HOH   B O    1 
HETATM 5266 O  O    . HOH   E 4 .   ? -14.83500 -16.44600 -13.32800 1.000 36.73407 ? 1529 HOH   B O    1 
HETATM 5267 O  O    . HOH   E 4 .   ? -8.62000  -24.22000 -16.51500 1.000 52.91497 ? 1530 HOH   B O    1 
HETATM 5268 O  O    . HOH   E 4 .   ? -7.58500  -36.46100 -31.45700 1.000 27.33868 ? 1531 HOH   B O    1 
HETATM 5269 O  O    . HOH   E 4 .   ? -24.59200 -47.35500 -40.41100 1.000 44.35010 ? 1532 HOH   B O    1 
HETATM 5270 O  O    . HOH   E 4 .   ? -31.25800 -39.83400 -23.57600 1.000 39.23021 ? 1533 HOH   B O    1 
HETATM 5271 O  O    . HOH   E 4 .   ? -5.50700  -42.95300 -46.13900 1.000 43.84593 ? 1534 HOH   B O    1 
HETATM 5272 O  O    . HOH   E 4 .   ? -36.63600 -31.91900 -29.50600 1.000 42.84554 ? 1535 HOH   B O    1 
HETATM 5273 O  O    . HOH   E 4 .   ? -27.91800 -30.46300 -19.29400 1.000 33.24733 ? 1536 HOH   B O    1 
HETATM 5274 O  O    . HOH   E 4 .   ? -24.93200 -8.07300  -27.37500 1.000 46.21119 ? 1537 HOH   B O    1 
HETATM 5275 O  O    . HOH   E 4 .   ? -3.68000  -27.31000 -50.06800 1.000 54.34601 ? 1538 HOH   B O    1 
HETATM 5276 O  O    . HOH   E 4 .   ? -13.50800 -28.57900 -23.52800 1.000 32.87427 ? 1539 HOH   B O    1 
HETATM 5277 O  O    . HOH   E 4 .   ? 2.09600   -26.65700 -43.94400 1.000 42.15805 ? 1540 HOH   B O    1 
HETATM 5278 O  O    . HOH   E 4 .   ? -6.79800  -12.09900 -17.24400 1.000 49.28060 ? 1541 HOH   B O    1 
HETATM 5279 O  O    . HOH   E 4 .   ? -18.05100 -26.20200 -39.20700 1.000 38.15806 ? 1542 HOH   B O    1 
HETATM 5280 O  O    . HOH   E 4 .   ? -2.78700  -29.27100 -19.39200 1.000 48.95905 ? 1543 HOH   B O    1 
HETATM 5281 O  O    . HOH   E 4 .   ? 4.762     -9.722    -20.019   1.000 44.25011 ? 1544 HOH   B O    1 
HETATM 5282 O  O    . HOH   E 4 .   ? -11.09000 -21.93200 -13.73600 1.000 36.56955 ? 1545 HOH   B O    1 
HETATM 5283 O  O    . HOH   E 4 .   ? -28.04700 -33.32900 -19.89600 1.000 60.70166 ? 1546 HOH   B O    1 
HETATM 5284 O  O    . HOH   E 4 .   ? -9.84300  -36.25800 -29.74800 1.000 27.58226 ? 1547 HOH   B O    1 
HETATM 5285 O  O    . HOH   E 4 .   ? 6.38700   -28.71500 -23.60400 1.000 55.59257 ? 1548 HOH   B O    1 
HETATM 5286 O  O    . HOH   E 4 .   ? 3.224     -46.511   -41.099   1.000 54.10016 ? 1549 HOH   B O    1 
HETATM 5287 O  O    . HOH   E 4 .   ? -32.599   -22.801   -22.091   1.000 41.76747 ? 1550 HOH   B O    1 
HETATM 5288 O  O    . HOH   E 4 .   ? -5.27800  -29.86800 -20.69500 1.000 49.13436 ? 1551 HOH   B O    1 
HETATM 5289 O  O    . HOH   E 4 .   ? -24.01100 -53.97200 -19.50400 1.000 59.08447 ? 1552 HOH   B O    1 
HETATM 5290 O  O    . HOH   E 4 .   ? -10.00100 -24.10300 -37.07800 1.000 26.67772 ? 1553 HOH   B O    1 
HETATM 5291 O  O    . HOH   E 4 .   ? -20.38600 -32.06200 -13.91200 1.000 39.34562 ? 1554 HOH   B O    1 
HETATM 5292 O  O    . HOH   E 4 .   ? -19.52400 -27.44200 -10.14100 1.000 33.29262 ? 1555 HOH   B O    1 
HETATM 5293 O  O    . HOH   E 4 .   ? -21.25400 -20.45200 -15.11000 1.000 31.37488 ? 1556 HOH   B O    1 
HETATM 5294 O  O    . HOH   E 4 .   ? -2.22300  -43.35300 -48.23900 1.000 52.98817 ? 1557 HOH   B O    1 
HETATM 5295 O  O    . HOH   E 4 .   ? -9.70300  -52.36800 -33.70000 1.000 34.88674 ? 1558 HOH   B O    1 
HETATM 5296 O  O    . HOH   E 4 .   ? 3.65200   -31.96800 -25.67500 1.000 39.63657 ? 1559 HOH   B O    1 
HETATM 5297 O  O    . HOH   E 4 .   ? -14.07300 -2.70800  -25.95300 1.000 48.16937 ? 1560 HOH   B O    1 
HETATM 5298 O  O    . HOH   E 4 .   ? -19.270   -41.721   -45.649   1.000 45.67577 ? 1561 HOH   B O    1 
HETATM 5299 O  O    . HOH   E 4 .   ? -6.56400  -52.57100 -46.56600 1.000 49.94613 ? 1562 HOH   B O    1 
HETATM 5300 O  O    . HOH   E 4 .   ? -27.45400 -46.00200 -23.03300 1.000 49.09032 ? 1563 HOH   B O    1 
HETATM 5301 O  O    . HOH   E 4 .   ? -4.24600  -2.72300  -22.55200 1.000 48.38530 ? 1564 HOH   B O    1 
HETATM 5302 O  O    . HOH   E 4 .   ? -11.01700 -51.64300 -23.52200 1.000 50.29968 ? 1565 HOH   B O    1 
HETATM 5303 O  O    . HOH   E 4 .   ? -16.95500 -49.12100 -18.58400 1.000 43.91300 ? 1566 HOH   B O    1 
HETATM 5304 O  O    . HOH   E 4 .   ? -4.14400  -24.76000 -45.90200 1.000 41.60887 ? 1567 HOH   B O    1 
HETATM 5305 O  O    . HOH   E 4 .   ? -25.95100 -35.16600 -18.30000 1.000 51.36799 ? 1568 HOH   B O    1 
HETATM 5306 O  O    . HOH   E 4 .   ? -33.73000 -21.42200 -28.62400 1.000 42.94985 ? 1569 HOH   B O    1 
HETATM 5307 O  O    . HOH   E 4 .   ? -11.49600 -20.80000 -10.55700 1.000 47.76082 ? 1570 HOH   B O    1 
HETATM 5308 O  O    . HOH   E 4 .   ? -28.44900 -47.21400 -26.85400 1.000 53.56448 ? 1571 HOH   B O    1 
HETATM 5309 O  O    . HOH   E 4 .   ? -26.04000 -50.27400 -26.46300 1.000 49.17683 ? 1572 HOH   B O    1 
HETATM 5310 O  O    . HOH   E 4 .   ? -5.22000  -14.29900 -16.14700 1.000 49.20448 ? 1573 HOH   B O    1 
HETATM 5311 O  O    . HOH   E 4 .   ? -18.08000 -54.56700 -37.39400 1.000 50.96662 ? 1574 HOH   B O    1 
HETATM 5312 O  O    . HOH   E 4 .   ? 7.95400   -38.12400 -36.31700 1.000 57.47758 ? 1575 HOH   B O    1 
HETATM 5313 O  O    . HOH   E 4 .   ? -29.47100 -30.97900 -17.00900 1.000 36.47634 ? 1576 HOH   B O    1 
HETATM 5314 O  O    . HOH   E 4 .   ? -19.37100 -31.61300 -12.11400 1.000 39.08289 ? 1577 HOH   B O    1 
HETATM 5315 O  O    . HOH   E 4 .   ? -11.629   -46.284   -52.568   1.000 46.84296 ? 1578 HOH   B O    1 
HETATM 5316 O  O    . HOH   E 4 .   ? -11.63400 -34.71300 -47.53900 1.000 51.02731 ? 1579 HOH   B O    1 
HETATM 5317 O  O    . HOH   E 4 .   ? -18.57700 -28.71600 -38.39900 1.000 38.31973 ? 1580 HOH   B O    1 
HETATM 5318 O  O    . HOH   E 4 .   ? 3.35300   -8.64600  -18.41400 1.000 41.52715 ? 1581 HOH   B O    1 
HETATM 5319 O  O    . HOH   E 4 .   ? -11.10900 -32.64200 -33.09900 1.000 29.19082 ? 1582 HOH   B O    1 
HETATM 5320 O  O    . HOH   E 4 .   ? -13.07000 -32.42800 -47.26000 1.000 49.79175 ? 1583 HOH   B O    1 
HETATM 5321 O  O    . HOH   E 4 .   ? -21.86600 -16.51100 -15.98700 1.000 47.75938 ? 1584 HOH   B O    1 
HETATM 5322 O  O    . HOH   E 4 .   ? -14.75100 -28.69000 -32.59000 1.000 40.04675 ? 1585 HOH   B O    1 
HETATM 5323 O  O    . HOH   E 4 .   ? 4.90000   -31.18000 -28.07300 1.000 42.76951 ? 1586 HOH   B O    1 
HETATM 5324 O  O    . HOH   E 4 .   ? -16.89000 -15.48400 -11.83900 1.000 57.76113 ? 1587 HOH   B O    1 
HETATM 5325 O  O    . HOH   E 4 .   ? -23.44500 -20.69800 -43.56400 1.000 50.48550 ? 1588 HOH   B O    1 
HETATM 5326 O  O    . HOH   E 4 .   ? -20.69400 -31.36800 -9.48900  1.000 34.86635 ? 1589 HOH   B O    1 
HETATM 5327 O  O    . HOH   E 4 .   ? -23.63200 -31.55300 -9.21700  1.000 46.94778 ? 1590 HOH   B O    1 
HETATM 5328 O  O    . HOH   E 4 .   ? -15.83300 -30.10700 -35.13700 1.000 37.11398 ? 1591 HOH   B O    1 
HETATM 5329 O  O    . HOH   E 4 .   ? -33.43500 -18.04900 -25.68900 1.000 49.98355 ? 1592 HOH   B O    1 
HETATM 5330 O  O    . HOH   E 4 .   ? -17.95900 -16.15400 -10.02200 1.000 40.66362 ? 1593 HOH   B O    1 
HETATM 5331 O  O    . HOH   E 4 .   ? 3.41700   -32.19500 -32.71700 1.000 49.89295 ? 1594 HOH   B O    1 
HETATM 5332 O  O    . HOH   E 4 .   ? -13.25800 -39.25500 -17.78700 1.000 49.04864 ? 1595 HOH   B O    1 
HETATM 5333 O  O    . HOH   E 4 .   ? -18.787   -37.729   -46.502   1.000 31.73131 ? 1596 HOH   B O    1 
HETATM 5334 O  O    . HOH   E 4 .   ? 4.73400   -34.78400 -31.08500 1.000 46.30168 ? 1597 HOH   B O    1 
HETATM 5335 O  O    . HOH   E 4 .   ? -20.93500 -6.02000  -25.41300 1.000 57.19007 ? 1598 HOH   B O    1 
HETATM 5336 O  O    . HOH   E 4 .   ? -9.82400  -10.07500 -13.41700 1.000 54.93419 ? 1599 HOH   B O    1 
HETATM 5337 O  O    . HOH   E 4 .   ? -4.59500  -46.39500 -47.79100 1.000 40.80032 ? 1600 HOH   B O    1 
HETATM 5338 O  O    . HOH   E 4 .   ? -35.99300 -22.08800 -26.06000 1.000 42.50436 ? 1601 HOH   B O    1 
HETATM 5339 O  O    . HOH   E 4 .   ? -6.69600  -1.90200  -25.55000 1.000 46.10500 ? 1602 HOH   B O    1 
HETATM 5340 O  O    . HOH   E 4 .   ? -27.72800 -32.01800 -13.28400 1.000 52.03573 ? 1603 HOH   B O    1 
HETATM 5341 O  O    . HOH   E 4 .   ? -35.81500 -23.55500 -23.72000 1.000 37.11960 ? 1604 HOH   B O    1 
HETATM 5342 O  O    . HOH   E 4 .   ? -25.36300 -20.25200 -13.80900 1.000 42.31207 ? 1605 HOH   B O    1 
HETATM 5343 O  O    . HOH   E 4 .   ? -30.24500 -33.27800 -18.09100 1.000 56.33550 ? 1606 HOH   B O    1 
HETATM 5344 O  O    . HOH   E 4 .   ? -24.56300 -23.37400 -42.27300 1.000 46.47263 ? 1607 HOH   B O    1 
HETATM 5345 O  O    . HOH   E 4 .   ? 5.29900   -38.01400 -29.96800 1.000 43.90287 ? 1608 HOH   B O    1 
HETATM 5346 O  O    . HOH   E 4 .   ? -12.41400 -33.33100 -35.77800 1.000 50.22792 ? 1609 HOH   B O    1 
HETATM 5347 O  O    . HOH   E 4 .   ? -13.48300 -56.14800 -37.74100 1.000 52.76466 ? 1610 HOH   B O    1 
HETATM 5348 O  O    . HOH   E 4 .   ? -18.75200 -33.78800 -46.21600 1.000 48.10337 ? 1611 HOH   B O    1 
HETATM 5349 O  O    . HOH   E 4 .   ? -12.60300 -16.82200 -12.16600 1.000 51.41160 ? 1612 HOH   B O    1 
HETATM 5350 O  O    . HOH   E 4 .   ? -16.75200 -32.54400 -42.05300 1.000 38.39472 ? 1613 HOH   B O    1 
HETATM 5351 O  O    . HOH   E 4 .   ? -25.11200 -19.12700 -16.74300 1.000 35.70646 ? 1614 HOH   B O    1 
HETATM 5352 O  O    . HOH   E 4 .   ? -16.37400 -32.28200 -15.88500 1.000 35.95902 ? 1615 HOH   B O    1 
HETATM 5353 O  O    . HOH   E 4 .   ? 2.90700   -38.13600 -23.56600 1.000 47.85136 ? 1616 HOH   B O    1 
HETATM 5354 O  O    . HOH   E 4 .   ? 4.42200   -25.33900 -44.91200 1.000 55.47889 ? 1617 HOH   B O    1 
# 
