data_9B9T
# 
_entry.id   9B9T 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9B9T         pdb_00009b9t 10.2210/pdb9b9t/pdb 
WWPDB D_1000282942 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2024-11-06 
2 'Structure model' 1 1 2024-12-04 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_CSD'          
4  2 'Structure model' '_citation.journal_id_ISSN'         
5  2 'Structure model' '_citation.journal_volume'          
6  2 'Structure model' '_citation.page_first'              
7  2 'Structure model' '_citation.page_last'               
8  2 'Structure model' '_citation.pdbx_database_id_DOI'    
9  2 'Structure model' '_citation.pdbx_database_id_PubMed' 
10 2 'Structure model' '_citation.title'                   
11 2 'Structure model' '_citation.year'                    
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9B9T 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-03 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              mvedadi@oicr.on.ca 
_pdbx_contact_author.name_first         Masoud 
_pdbx_contact_author.name_last          Vedadi 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0574-0169 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Mabanglo, M.F.' 1 0000-0003-4671-4159 
'Wilson, B.J.'   2 0009-0003-1132-8095 
'Krausser, C.'   3 0009-0004-4576-5258 
'Hoffer, L.'     4 0000-0003-1906-7128 
'Al-awar, R.'    5 0000-0002-4185-055X 
'Vedadi, M.'     6 0000-0002-0574-0169 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            15 
_citation.language                  ? 
_citation.page_first                10165 
_citation.page_last                 10165 
_citation.title                     
'Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-024-54500-x 
_citation.pdbx_database_id_PubMed   39580491 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Mabanglo, M.F.'       1  ?                   
primary 'Wilson, B.'           2  ?                   
primary 'Noureldin, M.'        3  ?                   
primary 'Kimani, S.W.'         4  0000-0002-6960-3833 
primary 'Mamai, A.'            5  ?                   
primary 'Krausser, C.'         6  ?                   
primary 'Gonzalez-Alvarez, H.' 7  ?                   
primary 'Srivastava, S.'       8  ?                   
primary 'Mohammed, M.'         9  ?                   
primary 'Hoffer, L.'           10 0000-0003-1906-7128 
primary 'Chan, M.'             11 ?                   
primary 'Avrumutsoae, J.'      12 ?                   
primary 'Li, A.S.M.'           13 ?                   
primary 'Hajian, T.'           14 ?                   
primary 'Tucker, S.'           15 ?                   
primary 'Green, S.'            16 0000-0002-2960-9683 
primary 'Szewczyk, M.'         17 ?                   
primary 'Barsyte-Lovejoy, D.'  18 0000-0002-6560-9621 
primary 'Santhakumar, V.'      19 0000-0002-7001-557X 
primary 'Ackloo, S.'           20 0000-0002-9696-1839 
primary 'Loppnau, P.'          21 ?                   
primary 'Li, Y.'               22 0000-0002-9512-5265 
primary 'Seitova, A.'          23 ?                   
primary 'Kiyota, T.'           24 0000-0001-6313-3482 
primary 'Wang, J.G.'           25 ?                   
primary 'Prive, G.G.'          26 ?                   
primary 'Kuntz, D.A.'          27 0000-0003-3584-4804 
primary 'Patel, B.'            28 ?                   
primary 'Rathod, V.'           29 ?                   
primary 'Vala, A.'             30 ?                   
primary 'Rout, B.'             31 ?                   
primary 'Aman, A.'             32 0000-0002-0275-205X 
primary 'Poda, G.'             33 ?                   
primary 'Uehling, D.'          34 ?                   
primary 'Ramnauth, J.'         35 ?                   
primary 'Halabelian, L.'       36 0000-0003-4361-3619 
primary 'Marcellus, R.'        37 ?                   
primary 'Al-Awar, R.'          38 ?                   
primary 'Vedadi, M.'           39 0000-0002-0574-0169 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'WD repeat-containing protein 5' 36433.207 1   ?        ? ?                    ? 
2 polymer     man 'DDB1- and CUL4-associated factor 1' 38298.820 1   2.7.11.1 ? 'residues 1080-1390' ? 
3 non-polymer syn 
;N-{(1P)-5'-[(17-{(4P)-4-[(2P)-4-{[(1R)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]carbamoyl}-3-(4-chloro-2-fluorophenyl)-1H-pyrrol-2-yl]-1H-pyrazol-1-yl}-16-oxo-3,6,9,12-tetraoxa-15-azaheptadecan-1-yl)carbamoyl]-2'-fluoro-4-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl][1,1'-biphenyl]-3-yl}-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
;
1309.144  1   ?        ? ?                    ? 
4 water       nat water 18.015    540 ?        ? ?                    ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 'BMP2-induced 3-kb gene protein'                                                                
2 'HIV-1 Vpr-binding protein,VprBP,Serine/threonine-protein kinase VPRBP,Vpr-interacting protein' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;MHHHHHHSSGRENLYFQGTQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG
HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK
TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK
GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDK
TIKLWKSDC
;
;MHHHHHHSSGRENLYFQGTQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG
HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK
TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK
GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDK
TIKLWKSDC
;
A ? 
2 'polypeptide(L)' no no 
;MGSSHHHHHHSSGRENLYFQGSSRASAFRPISVFREANEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYN
CHNSAITHLEPSRDGSLLLTSATWSQPLSALWGMKSVFDMKHSFTEDHYVEFSKHSQDRVIGTKGDIAHIYDIQTGNKLL
TLFNPDLANNYKRNCATFNPTDDLVLNDGVLWDVRSAQAIHKFDKFNMNISGVFHPNGLEVIINTEIWDLRTFHLLHTVP
ALDQCRVVFNHTGTVMYGAMLQADDEDDLMEERMKSPFGSSFRTFNATDYKPIATIDVKRNIFDLCTDTKDCYLAVIENQ
GSMDALNMDTVCRLYEVG
;
;MGSSHHHHHHSSGRENLYFQGSSRASAFRPISVFREANEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYN
CHNSAITHLEPSRDGSLLLTSATWSQPLSALWGMKSVFDMKHSFTEDHYVEFSKHSQDRVIGTKGDIAHIYDIQTGNKLL
TLFNPDLANNYKRNCATFNPTDDLVLNDGVLWDVRSAQAIHKFDKFNMNISGVFHPNGLEVIINTEIWDLRTFHLLHTVP
ALDQCRVVFNHTGTVMYGAMLQADDEDDLMEERMKSPFGSSFRTFNATDYKPIATIDVKRNIFDLCTDTKDCYLAVIENQ
GSMDALNMDTVCRLYEVG
;
B ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 
;N-{(1P)-5'-[(17-{(4P)-4-[(2P)-4-{[(1R)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]carbamoyl}-3-(4-chloro-2-fluorophenyl)-1H-pyrrol-2-yl]-1H-pyrazol-1-yl}-16-oxo-3,6,9,12-tetraoxa-15-azaheptadecan-1-yl)carbamoyl]-2'-fluoro-4-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl][1,1'-biphenyl]-3-yl}-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
;
A1ANM 
4 water HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   HIS n 
1 3   HIS n 
1 4   HIS n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   SER n 
1 9   SER n 
1 10  GLY n 
1 11  ARG n 
1 12  GLU n 
1 13  ASN n 
1 14  LEU n 
1 15  TYR n 
1 16  PHE n 
1 17  GLN n 
1 18  GLY n 
1 19  THR n 
1 20  GLN n 
1 21  SER n 
1 22  LYS n 
1 23  PRO n 
1 24  THR n 
1 25  PRO n 
1 26  VAL n 
1 27  LYS n 
1 28  PRO n 
1 29  ASN n 
1 30  TYR n 
1 31  ALA n 
1 32  LEU n 
1 33  LYS n 
1 34  PHE n 
1 35  THR n 
1 36  LEU n 
1 37  ALA n 
1 38  GLY n 
1 39  HIS n 
1 40  THR n 
1 41  LYS n 
1 42  ALA n 
1 43  VAL n 
1 44  SER n 
1 45  SER n 
1 46  VAL n 
1 47  LYS n 
1 48  PHE n 
1 49  SER n 
1 50  PRO n 
1 51  ASN n 
1 52  GLY n 
1 53  GLU n 
1 54  TRP n 
1 55  LEU n 
1 56  ALA n 
1 57  SER n 
1 58  SER n 
1 59  SER n 
1 60  ALA n 
1 61  ASP n 
1 62  LYS n 
1 63  LEU n 
1 64  ILE n 
1 65  LYS n 
1 66  ILE n 
1 67  TRP n 
1 68  GLY n 
1 69  ALA n 
1 70  TYR n 
1 71  ASP n 
1 72  GLY n 
1 73  LYS n 
1 74  PHE n 
1 75  GLU n 
1 76  LYS n 
1 77  THR n 
1 78  ILE n 
1 79  SER n 
1 80  GLY n 
1 81  HIS n 
1 82  LYS n 
1 83  LEU n 
1 84  GLY n 
1 85  ILE n 
1 86  SER n 
1 87  ASP n 
1 88  VAL n 
1 89  ALA n 
1 90  TRP n 
1 91  SER n 
1 92  SER n 
1 93  ASP n 
1 94  SER n 
1 95  ASN n 
1 96  LEU n 
1 97  LEU n 
1 98  VAL n 
1 99  SER n 
1 100 ALA n 
1 101 SER n 
1 102 ASP n 
1 103 ASP n 
1 104 LYS n 
1 105 THR n 
1 106 LEU n 
1 107 LYS n 
1 108 ILE n 
1 109 TRP n 
1 110 ASP n 
1 111 VAL n 
1 112 SER n 
1 113 SER n 
1 114 GLY n 
1 115 LYS n 
1 116 CYS n 
1 117 LEU n 
1 118 LYS n 
1 119 THR n 
1 120 LEU n 
1 121 LYS n 
1 122 GLY n 
1 123 HIS n 
1 124 SER n 
1 125 ASN n 
1 126 TYR n 
1 127 VAL n 
1 128 PHE n 
1 129 CYS n 
1 130 CYS n 
1 131 ASN n 
1 132 PHE n 
1 133 ASN n 
1 134 PRO n 
1 135 GLN n 
1 136 SER n 
1 137 ASN n 
1 138 LEU n 
1 139 ILE n 
1 140 VAL n 
1 141 SER n 
1 142 GLY n 
1 143 SER n 
1 144 PHE n 
1 145 ASP n 
1 146 GLU n 
1 147 SER n 
1 148 VAL n 
1 149 ARG n 
1 150 ILE n 
1 151 TRP n 
1 152 ASP n 
1 153 VAL n 
1 154 LYS n 
1 155 THR n 
1 156 GLY n 
1 157 LYS n 
1 158 CYS n 
1 159 LEU n 
1 160 LYS n 
1 161 THR n 
1 162 LEU n 
1 163 PRO n 
1 164 ALA n 
1 165 HIS n 
1 166 SER n 
1 167 ASP n 
1 168 PRO n 
1 169 VAL n 
1 170 SER n 
1 171 ALA n 
1 172 VAL n 
1 173 HIS n 
1 174 PHE n 
1 175 ASN n 
1 176 ARG n 
1 177 ASP n 
1 178 GLY n 
1 179 SER n 
1 180 LEU n 
1 181 ILE n 
1 182 VAL n 
1 183 SER n 
1 184 SER n 
1 185 SER n 
1 186 TYR n 
1 187 ASP n 
1 188 GLY n 
1 189 LEU n 
1 190 CYS n 
1 191 ARG n 
1 192 ILE n 
1 193 TRP n 
1 194 ASP n 
1 195 THR n 
1 196 ALA n 
1 197 SER n 
1 198 GLY n 
1 199 GLN n 
1 200 CYS n 
1 201 LEU n 
1 202 LYS n 
1 203 THR n 
1 204 LEU n 
1 205 ILE n 
1 206 ASP n 
1 207 ASP n 
1 208 ASP n 
1 209 ASN n 
1 210 PRO n 
1 211 PRO n 
1 212 VAL n 
1 213 SER n 
1 214 PHE n 
1 215 VAL n 
1 216 LYS n 
1 217 PHE n 
1 218 SER n 
1 219 PRO n 
1 220 ASN n 
1 221 GLY n 
1 222 LYS n 
1 223 TYR n 
1 224 ILE n 
1 225 LEU n 
1 226 ALA n 
1 227 ALA n 
1 228 THR n 
1 229 LEU n 
1 230 ASP n 
1 231 ASN n 
1 232 THR n 
1 233 LEU n 
1 234 LYS n 
1 235 LEU n 
1 236 TRP n 
1 237 ASP n 
1 238 TYR n 
1 239 SER n 
1 240 LYS n 
1 241 GLY n 
1 242 LYS n 
1 243 CYS n 
1 244 LEU n 
1 245 LYS n 
1 246 THR n 
1 247 TYR n 
1 248 THR n 
1 249 GLY n 
1 250 HIS n 
1 251 LYS n 
1 252 ASN n 
1 253 GLU n 
1 254 LYS n 
1 255 TYR n 
1 256 CYS n 
1 257 ILE n 
1 258 PHE n 
1 259 ALA n 
1 260 ASN n 
1 261 PHE n 
1 262 SER n 
1 263 VAL n 
1 264 THR n 
1 265 GLY n 
1 266 GLY n 
1 267 LYS n 
1 268 TRP n 
1 269 ILE n 
1 270 VAL n 
1 271 SER n 
1 272 GLY n 
1 273 SER n 
1 274 GLU n 
1 275 ASP n 
1 276 ASN n 
1 277 LEU n 
1 278 VAL n 
1 279 TYR n 
1 280 ILE n 
1 281 TRP n 
1 282 ASN n 
1 283 LEU n 
1 284 GLN n 
1 285 THR n 
1 286 LYS n 
1 287 GLU n 
1 288 ILE n 
1 289 VAL n 
1 290 GLN n 
1 291 LYS n 
1 292 LEU n 
1 293 GLN n 
1 294 GLY n 
1 295 HIS n 
1 296 THR n 
1 297 ASP n 
1 298 VAL n 
1 299 VAL n 
1 300 ILE n 
1 301 SER n 
1 302 THR n 
1 303 ALA n 
1 304 CYS n 
1 305 HIS n 
1 306 PRO n 
1 307 THR n 
1 308 GLU n 
1 309 ASN n 
1 310 ILE n 
1 311 ILE n 
1 312 ALA n 
1 313 SER n 
1 314 ALA n 
1 315 ALA n 
1 316 LEU n 
1 317 GLU n 
1 318 ASN n 
1 319 ASP n 
1 320 LYS n 
1 321 THR n 
1 322 ILE n 
1 323 LYS n 
1 324 LEU n 
1 325 TRP n 
1 326 LYS n 
1 327 SER n 
1 328 ASP n 
1 329 CYS n 
2 1   MET n 
2 2   GLY n 
2 3   SER n 
2 4   SER n 
2 5   HIS n 
2 6   HIS n 
2 7   HIS n 
2 8   HIS n 
2 9   HIS n 
2 10  HIS n 
2 11  SER n 
2 12  SER n 
2 13  GLY n 
2 14  ARG n 
2 15  GLU n 
2 16  ASN n 
2 17  LEU n 
2 18  TYR n 
2 19  PHE n 
2 20  GLN n 
2 21  GLY n 
2 22  SER n 
2 23  SER n 
2 24  ARG n 
2 25  ALA n 
2 26  SER n 
2 27  ALA n 
2 28  PHE n 
2 29  ARG n 
2 30  PRO n 
2 31  ILE n 
2 32  SER n 
2 33  VAL n 
2 34  PHE n 
2 35  ARG n 
2 36  GLU n 
2 37  ALA n 
2 38  ASN n 
2 39  GLU n 
2 40  ASP n 
2 41  GLU n 
2 42  SER n 
2 43  GLY n 
2 44  PHE n 
2 45  THR n 
2 46  CYS n 
2 47  CYS n 
2 48  ALA n 
2 49  PHE n 
2 50  SER n 
2 51  ALA n 
2 52  ARG n 
2 53  GLU n 
2 54  ARG n 
2 55  PHE n 
2 56  LEU n 
2 57  MET n 
2 58  LEU n 
2 59  GLY n 
2 60  THR n 
2 61  CYS n 
2 62  THR n 
2 63  GLY n 
2 64  GLN n 
2 65  LEU n 
2 66  LYS n 
2 67  LEU n 
2 68  TYR n 
2 69  ASN n 
2 70  VAL n 
2 71  PHE n 
2 72  SER n 
2 73  GLY n 
2 74  GLN n 
2 75  GLU n 
2 76  GLU n 
2 77  ALA n 
2 78  SER n 
2 79  TYR n 
2 80  ASN n 
2 81  CYS n 
2 82  HIS n 
2 83  ASN n 
2 84  SER n 
2 85  ALA n 
2 86  ILE n 
2 87  THR n 
2 88  HIS n 
2 89  LEU n 
2 90  GLU n 
2 91  PRO n 
2 92  SER n 
2 93  ARG n 
2 94  ASP n 
2 95  GLY n 
2 96  SER n 
2 97  LEU n 
2 98  LEU n 
2 99  LEU n 
2 100 THR n 
2 101 SER n 
2 102 ALA n 
2 103 THR n 
2 104 TRP n 
2 105 SER n 
2 106 GLN n 
2 107 PRO n 
2 108 LEU n 
2 109 SER n 
2 110 ALA n 
2 111 LEU n 
2 112 TRP n 
2 113 GLY n 
2 114 MET n 
2 115 LYS n 
2 116 SER n 
2 117 VAL n 
2 118 PHE n 
2 119 ASP n 
2 120 MET n 
2 121 LYS n 
2 122 HIS n 
2 123 SER n 
2 124 PHE n 
2 125 THR n 
2 126 GLU n 
2 127 ASP n 
2 128 HIS n 
2 129 TYR n 
2 130 VAL n 
2 131 GLU n 
2 132 PHE n 
2 133 SER n 
2 134 LYS n 
2 135 HIS n 
2 136 SER n 
2 137 GLN n 
2 138 ASP n 
2 139 ARG n 
2 140 VAL n 
2 141 ILE n 
2 142 GLY n 
2 143 THR n 
2 144 LYS n 
2 145 GLY n 
2 146 ASP n 
2 147 ILE n 
2 148 ALA n 
2 149 HIS n 
2 150 ILE n 
2 151 TYR n 
2 152 ASP n 
2 153 ILE n 
2 154 GLN n 
2 155 THR n 
2 156 GLY n 
2 157 ASN n 
2 158 LYS n 
2 159 LEU n 
2 160 LEU n 
2 161 THR n 
2 162 LEU n 
2 163 PHE n 
2 164 ASN n 
2 165 PRO n 
2 166 ASP n 
2 167 LEU n 
2 168 ALA n 
2 169 ASN n 
2 170 ASN n 
2 171 TYR n 
2 172 LYS n 
2 173 ARG n 
2 174 ASN n 
2 175 CYS n 
2 176 ALA n 
2 177 THR n 
2 178 PHE n 
2 179 ASN n 
2 180 PRO n 
2 181 THR n 
2 182 ASP n 
2 183 ASP n 
2 184 LEU n 
2 185 VAL n 
2 186 LEU n 
2 187 ASN n 
2 188 ASP n 
2 189 GLY n 
2 190 VAL n 
2 191 LEU n 
2 192 TRP n 
2 193 ASP n 
2 194 VAL n 
2 195 ARG n 
2 196 SER n 
2 197 ALA n 
2 198 GLN n 
2 199 ALA n 
2 200 ILE n 
2 201 HIS n 
2 202 LYS n 
2 203 PHE n 
2 204 ASP n 
2 205 LYS n 
2 206 PHE n 
2 207 ASN n 
2 208 MET n 
2 209 ASN n 
2 210 ILE n 
2 211 SER n 
2 212 GLY n 
2 213 VAL n 
2 214 PHE n 
2 215 HIS n 
2 216 PRO n 
2 217 ASN n 
2 218 GLY n 
2 219 LEU n 
2 220 GLU n 
2 221 VAL n 
2 222 ILE n 
2 223 ILE n 
2 224 ASN n 
2 225 THR n 
2 226 GLU n 
2 227 ILE n 
2 228 TRP n 
2 229 ASP n 
2 230 LEU n 
2 231 ARG n 
2 232 THR n 
2 233 PHE n 
2 234 HIS n 
2 235 LEU n 
2 236 LEU n 
2 237 HIS n 
2 238 THR n 
2 239 VAL n 
2 240 PRO n 
2 241 ALA n 
2 242 LEU n 
2 243 ASP n 
2 244 GLN n 
2 245 CYS n 
2 246 ARG n 
2 247 VAL n 
2 248 VAL n 
2 249 PHE n 
2 250 ASN n 
2 251 HIS n 
2 252 THR n 
2 253 GLY n 
2 254 THR n 
2 255 VAL n 
2 256 MET n 
2 257 TYR n 
2 258 GLY n 
2 259 ALA n 
2 260 MET n 
2 261 LEU n 
2 262 GLN n 
2 263 ALA n 
2 264 ASP n 
2 265 ASP n 
2 266 GLU n 
2 267 ASP n 
2 268 ASP n 
2 269 LEU n 
2 270 MET n 
2 271 GLU n 
2 272 GLU n 
2 273 ARG n 
2 274 MET n 
2 275 LYS n 
2 276 SER n 
2 277 PRO n 
2 278 PHE n 
2 279 GLY n 
2 280 SER n 
2 281 SER n 
2 282 PHE n 
2 283 ARG n 
2 284 THR n 
2 285 PHE n 
2 286 ASN n 
2 287 ALA n 
2 288 THR n 
2 289 ASP n 
2 290 TYR n 
2 291 LYS n 
2 292 PRO n 
2 293 ILE n 
2 294 ALA n 
2 295 THR n 
2 296 ILE n 
2 297 ASP n 
2 298 VAL n 
2 299 LYS n 
2 300 ARG n 
2 301 ASN n 
2 302 ILE n 
2 303 PHE n 
2 304 ASP n 
2 305 LEU n 
2 306 CYS n 
2 307 THR n 
2 308 ASP n 
2 309 THR n 
2 310 LYS n 
2 311 ASP n 
2 312 CYS n 
2 313 TYR n 
2 314 LEU n 
2 315 ALA n 
2 316 VAL n 
2 317 ILE n 
2 318 GLU n 
2 319 ASN n 
2 320 GLN n 
2 321 GLY n 
2 322 SER n 
2 323 MET n 
2 324 ASP n 
2 325 ALA n 
2 326 LEU n 
2 327 ASN n 
2 328 MET n 
2 329 ASP n 
2 330 THR n 
2 331 VAL n 
2 332 CYS n 
2 333 ARG n 
2 334 LEU n 
2 335 TYR n 
2 336 GLU n 
2 337 VAL n 
2 338 GLY n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 329 human ? 'WDR5, BIG3'                  ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
;Escherichia coli 'BL21-Gold(DE3)pLysS AG'
;
866768 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 338 human ? 'DCAF1, KIAA0800, RIP, VPRBP' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Spodoptera frugiperda'                     7108   ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1ANM non-polymer         . 
;N-{(1P)-5'-[(17-{(4P)-4-[(2P)-4-{[(1R)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]carbamoyl}-3-(4-chloro-2-fluorophenyl)-1H-pyrrol-2-yl]-1H-pyrazol-1-yl}-16-oxo-3,6,9,12-tetraoxa-15-azaheptadecan-1-yl)carbamoyl]-2'-fluoro-4-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl][1,1'-biphenyl]-3-yl}-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
;
OICR-40407 'C62 H65 Cl2 F6 N11 O10' 1309.144 
ALA   'L-peptide linking' y ALANINE ?          'C3 H7 N O2'             89.093   
ARG   'L-peptide linking' y ARGININE ?          'C6 H15 N4 O2 1'         175.209  
ASN   'L-peptide linking' y ASPARAGINE ?          'C4 H8 N2 O3'            132.118  
ASP   'L-peptide linking' y 'ASPARTIC ACID' ?          'C4 H7 N O4'             133.103  
CYS   'L-peptide linking' y CYSTEINE ?          'C3 H7 N O2 S'           121.158  
GLN   'L-peptide linking' y GLUTAMINE ?          'C5 H10 N2 O3'           146.144  
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ?          'C5 H9 N O4'             147.129  
GLY   'peptide linking'   y GLYCINE ?          'C2 H5 N O2'             75.067   
HIS   'L-peptide linking' y HISTIDINE ?          'C6 H10 N3 O2 1'         156.162  
HOH   non-polymer         . WATER ?          'H2 O'                   18.015   
ILE   'L-peptide linking' y ISOLEUCINE ?          'C6 H13 N O2'            131.173  
LEU   'L-peptide linking' y LEUCINE ?          'C6 H13 N O2'            131.173  
LYS   'L-peptide linking' y LYSINE ?          'C6 H15 N2 O2 1'         147.195  
MET   'L-peptide linking' y METHIONINE ?          'C5 H11 N O2 S'          149.211  
PHE   'L-peptide linking' y PHENYLALANINE ?          'C9 H11 N O2'            165.189  
PRO   'L-peptide linking' y PROLINE ?          'C5 H9 N O2'             115.130  
SER   'L-peptide linking' y SERINE ?          'C3 H7 N O3'             105.093  
THR   'L-peptide linking' y THREONINE ?          'C4 H9 N O3'             119.119  
TRP   'L-peptide linking' y TRYPTOPHAN ?          'C11 H12 N2 O2'          204.225  
TYR   'L-peptide linking' y TYROSINE ?          'C9 H11 N O3'            181.189  
VAL   'L-peptide linking' y VALINE ?          'C5 H11 N O2'            117.146  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   6    ?    ?   ?   A . n 
A 1 2   HIS 2   7    ?    ?   ?   A . n 
A 1 3   HIS 3   8    ?    ?   ?   A . n 
A 1 4   HIS 4   9    ?    ?   ?   A . n 
A 1 5   HIS 5   10   ?    ?   ?   A . n 
A 1 6   HIS 6   11   ?    ?   ?   A . n 
A 1 7   HIS 7   12   ?    ?   ?   A . n 
A 1 8   SER 8   13   ?    ?   ?   A . n 
A 1 9   SER 9   14   ?    ?   ?   A . n 
A 1 10  GLY 10  15   ?    ?   ?   A . n 
A 1 11  ARG 11  16   ?    ?   ?   A . n 
A 1 12  GLU 12  17   ?    ?   ?   A . n 
A 1 13  ASN 13  18   ?    ?   ?   A . n 
A 1 14  LEU 14  19   ?    ?   ?   A . n 
A 1 15  TYR 15  20   ?    ?   ?   A . n 
A 1 16  PHE 16  21   ?    ?   ?   A . n 
A 1 17  GLN 17  22   ?    ?   ?   A . n 
A 1 18  GLY 18  23   ?    ?   ?   A . n 
A 1 19  THR 19  24   ?    ?   ?   A . n 
A 1 20  GLN 20  25   ?    ?   ?   A . n 
A 1 21  SER 21  26   ?    ?   ?   A . n 
A 1 22  LYS 22  27   ?    ?   ?   A . n 
A 1 23  PRO 23  28   ?    ?   ?   A . n 
A 1 24  THR 24  29   ?    ?   ?   A . n 
A 1 25  PRO 25  30   30   PRO PRO A . n 
A 1 26  VAL 26  31   31   VAL VAL A . n 
A 1 27  LYS 27  32   32   LYS LYS A . n 
A 1 28  PRO 28  33   33   PRO PRO A . n 
A 1 29  ASN 29  34   34   ASN ASN A . n 
A 1 30  TYR 30  35   35   TYR TYR A . n 
A 1 31  ALA 31  36   36   ALA ALA A . n 
A 1 32  LEU 32  37   37   LEU LEU A . n 
A 1 33  LYS 33  38   38   LYS LYS A . n 
A 1 34  PHE 34  39   39   PHE PHE A . n 
A 1 35  THR 35  40   40   THR THR A . n 
A 1 36  LEU 36  41   41   LEU LEU A . n 
A 1 37  ALA 37  42   42   ALA ALA A . n 
A 1 38  GLY 38  43   43   GLY GLY A . n 
A 1 39  HIS 39  44   44   HIS HIS A . n 
A 1 40  THR 40  45   45   THR THR A . n 
A 1 41  LYS 41  46   46   LYS LYS A . n 
A 1 42  ALA 42  47   47   ALA ALA A . n 
A 1 43  VAL 43  48   48   VAL VAL A . n 
A 1 44  SER 44  49   49   SER SER A . n 
A 1 45  SER 45  50   50   SER SER A . n 
A 1 46  VAL 46  51   51   VAL VAL A . n 
A 1 47  LYS 47  52   52   LYS LYS A . n 
A 1 48  PHE 48  53   53   PHE PHE A . n 
A 1 49  SER 49  54   54   SER SER A . n 
A 1 50  PRO 50  55   55   PRO PRO A . n 
A 1 51  ASN 51  56   56   ASN ASN A . n 
A 1 52  GLY 52  57   57   GLY GLY A . n 
A 1 53  GLU 53  58   58   GLU GLU A . n 
A 1 54  TRP 54  59   59   TRP TRP A . n 
A 1 55  LEU 55  60   60   LEU LEU A . n 
A 1 56  ALA 56  61   61   ALA ALA A . n 
A 1 57  SER 57  62   62   SER SER A . n 
A 1 58  SER 58  63   63   SER SER A . n 
A 1 59  SER 59  64   64   SER SER A . n 
A 1 60  ALA 60  65   65   ALA ALA A . n 
A 1 61  ASP 61  66   66   ASP ASP A . n 
A 1 62  LYS 62  67   67   LYS LYS A . n 
A 1 63  LEU 63  68   68   LEU LEU A . n 
A 1 64  ILE 64  69   69   ILE ILE A . n 
A 1 65  LYS 65  70   70   LYS LYS A . n 
A 1 66  ILE 66  71   71   ILE ILE A . n 
A 1 67  TRP 67  72   72   TRP TRP A . n 
A 1 68  GLY 68  73   73   GLY GLY A . n 
A 1 69  ALA 69  74   74   ALA ALA A . n 
A 1 70  TYR 70  75   75   TYR TYR A . n 
A 1 71  ASP 71  76   76   ASP ASP A . n 
A 1 72  GLY 72  77   77   GLY GLY A . n 
A 1 73  LYS 73  78   78   LYS LYS A . n 
A 1 74  PHE 74  79   79   PHE PHE A . n 
A 1 75  GLU 75  80   80   GLU GLU A . n 
A 1 76  LYS 76  81   81   LYS LYS A . n 
A 1 77  THR 77  82   82   THR THR A . n 
A 1 78  ILE 78  83   83   ILE ILE A . n 
A 1 79  SER 79  84   84   SER SER A . n 
A 1 80  GLY 80  85   85   GLY GLY A . n 
A 1 81  HIS 81  86   86   HIS HIS A . n 
A 1 82  LYS 82  87   87   LYS LYS A . n 
A 1 83  LEU 83  88   88   LEU LEU A . n 
A 1 84  GLY 84  89   89   GLY GLY A . n 
A 1 85  ILE 85  90   90   ILE ILE A . n 
A 1 86  SER 86  91   91   SER SER A . n 
A 1 87  ASP 87  92   92   ASP ASP A . n 
A 1 88  VAL 88  93   93   VAL VAL A . n 
A 1 89  ALA 89  94   94   ALA ALA A . n 
A 1 90  TRP 90  95   95   TRP TRP A . n 
A 1 91  SER 91  96   96   SER SER A . n 
A 1 92  SER 92  97   97   SER SER A . n 
A 1 93  ASP 93  98   98   ASP ASP A . n 
A 1 94  SER 94  99   99   SER SER A . n 
A 1 95  ASN 95  100  100  ASN ASN A . n 
A 1 96  LEU 96  101  101  LEU LEU A . n 
A 1 97  LEU 97  102  102  LEU LEU A . n 
A 1 98  VAL 98  103  103  VAL VAL A . n 
A 1 99  SER 99  104  104  SER SER A . n 
A 1 100 ALA 100 105  105  ALA ALA A . n 
A 1 101 SER 101 106  106  SER SER A . n 
A 1 102 ASP 102 107  107  ASP ASP A . n 
A 1 103 ASP 103 108  108  ASP ASP A . n 
A 1 104 LYS 104 109  109  LYS LYS A . n 
A 1 105 THR 105 110  110  THR THR A . n 
A 1 106 LEU 106 111  111  LEU LEU A . n 
A 1 107 LYS 107 112  112  LYS LYS A . n 
A 1 108 ILE 108 113  113  ILE ILE A . n 
A 1 109 TRP 109 114  114  TRP TRP A . n 
A 1 110 ASP 110 115  115  ASP ASP A . n 
A 1 111 VAL 111 116  116  VAL VAL A . n 
A 1 112 SER 112 117  117  SER SER A . n 
A 1 113 SER 113 118  118  SER SER A . n 
A 1 114 GLY 114 119  119  GLY GLY A . n 
A 1 115 LYS 115 120  120  LYS LYS A . n 
A 1 116 CYS 116 121  121  CYS CYS A . n 
A 1 117 LEU 117 122  122  LEU LEU A . n 
A 1 118 LYS 118 123  123  LYS LYS A . n 
A 1 119 THR 119 124  124  THR THR A . n 
A 1 120 LEU 120 125  125  LEU LEU A . n 
A 1 121 LYS 121 126  126  LYS LYS A . n 
A 1 122 GLY 122 127  127  GLY GLY A . n 
A 1 123 HIS 123 128  128  HIS HIS A . n 
A 1 124 SER 124 129  129  SER SER A . n 
A 1 125 ASN 125 130  130  ASN ASN A . n 
A 1 126 TYR 126 131  131  TYR TYR A . n 
A 1 127 VAL 127 132  132  VAL VAL A . n 
A 1 128 PHE 128 133  133  PHE PHE A . n 
A 1 129 CYS 129 134  134  CYS CYS A . n 
A 1 130 CYS 130 135  135  CYS CYS A . n 
A 1 131 ASN 131 136  136  ASN ASN A . n 
A 1 132 PHE 132 137  137  PHE PHE A . n 
A 1 133 ASN 133 138  138  ASN ASN A . n 
A 1 134 PRO 134 139  139  PRO PRO A . n 
A 1 135 GLN 135 140  140  GLN GLN A . n 
A 1 136 SER 136 141  141  SER SER A . n 
A 1 137 ASN 137 142  142  ASN ASN A . n 
A 1 138 LEU 138 143  143  LEU LEU A . n 
A 1 139 ILE 139 144  144  ILE ILE A . n 
A 1 140 VAL 140 145  145  VAL VAL A . n 
A 1 141 SER 141 146  146  SER SER A . n 
A 1 142 GLY 142 147  147  GLY GLY A . n 
A 1 143 SER 143 148  148  SER SER A . n 
A 1 144 PHE 144 149  149  PHE PHE A . n 
A 1 145 ASP 145 150  150  ASP ASP A . n 
A 1 146 GLU 146 151  151  GLU GLU A . n 
A 1 147 SER 147 152  152  SER SER A . n 
A 1 148 VAL 148 153  153  VAL VAL A . n 
A 1 149 ARG 149 154  154  ARG ARG A . n 
A 1 150 ILE 150 155  155  ILE ILE A . n 
A 1 151 TRP 151 156  156  TRP TRP A . n 
A 1 152 ASP 152 157  157  ASP ASP A . n 
A 1 153 VAL 153 158  158  VAL VAL A . n 
A 1 154 LYS 154 159  159  LYS LYS A . n 
A 1 155 THR 155 160  160  THR THR A . n 
A 1 156 GLY 156 161  161  GLY GLY A . n 
A 1 157 LYS 157 162  162  LYS LYS A . n 
A 1 158 CYS 158 163  163  CYS CYS A . n 
A 1 159 LEU 159 164  164  LEU LEU A . n 
A 1 160 LYS 160 165  165  LYS LYS A . n 
A 1 161 THR 161 166  166  THR THR A . n 
A 1 162 LEU 162 167  167  LEU LEU A . n 
A 1 163 PRO 163 168  168  PRO PRO A . n 
A 1 164 ALA 164 169  169  ALA ALA A . n 
A 1 165 HIS 165 170  170  HIS HIS A . n 
A 1 166 SER 166 171  171  SER SER A . n 
A 1 167 ASP 167 172  172  ASP ASP A . n 
A 1 168 PRO 168 173  173  PRO PRO A . n 
A 1 169 VAL 169 174  174  VAL VAL A . n 
A 1 170 SER 170 175  175  SER SER A . n 
A 1 171 ALA 171 176  176  ALA ALA A . n 
A 1 172 VAL 172 177  177  VAL VAL A . n 
A 1 173 HIS 173 178  178  HIS HIS A . n 
A 1 174 PHE 174 179  179  PHE PHE A . n 
A 1 175 ASN 175 180  180  ASN ASN A . n 
A 1 176 ARG 176 181  181  ARG ARG A . n 
A 1 177 ASP 177 182  182  ASP ASP A . n 
A 1 178 GLY 178 183  183  GLY GLY A . n 
A 1 179 SER 179 184  184  SER SER A . n 
A 1 180 LEU 180 185  185  LEU LEU A . n 
A 1 181 ILE 181 186  186  ILE ILE A . n 
A 1 182 VAL 182 187  187  VAL VAL A . n 
A 1 183 SER 183 188  188  SER SER A . n 
A 1 184 SER 184 189  189  SER SER A . n 
A 1 185 SER 185 190  190  SER SER A . n 
A 1 186 TYR 186 191  191  TYR TYR A . n 
A 1 187 ASP 187 192  192  ASP ASP A . n 
A 1 188 GLY 188 193  193  GLY GLY A . n 
A 1 189 LEU 189 194  194  LEU LEU A . n 
A 1 190 CYS 190 195  195  CYS CYS A . n 
A 1 191 ARG 191 196  196  ARG ARG A . n 
A 1 192 ILE 192 197  197  ILE ILE A . n 
A 1 193 TRP 193 198  198  TRP TRP A . n 
A 1 194 ASP 194 199  199  ASP ASP A . n 
A 1 195 THR 195 200  200  THR THR A . n 
A 1 196 ALA 196 201  201  ALA ALA A . n 
A 1 197 SER 197 202  202  SER SER A . n 
A 1 198 GLY 198 203  203  GLY GLY A . n 
A 1 199 GLN 199 204  204  GLN GLN A . n 
A 1 200 CYS 200 205  205  CYS CYS A . n 
A 1 201 LEU 201 206  206  LEU LEU A . n 
A 1 202 LYS 202 207  207  LYS LYS A . n 
A 1 203 THR 203 208  208  THR THR A . n 
A 1 204 LEU 204 209  209  LEU LEU A . n 
A 1 205 ILE 205 210  210  ILE ILE A . n 
A 1 206 ASP 206 211  211  ASP ASP A . n 
A 1 207 ASP 207 212  212  ASP ASP A . n 
A 1 208 ASP 208 213  213  ASP ASP A . n 
A 1 209 ASN 209 214  214  ASN ASN A . n 
A 1 210 PRO 210 215  215  PRO PRO A . n 
A 1 211 PRO 211 216  216  PRO PRO A . n 
A 1 212 VAL 212 217  217  VAL VAL A . n 
A 1 213 SER 213 218  218  SER SER A . n 
A 1 214 PHE 214 219  219  PHE PHE A . n 
A 1 215 VAL 215 220  220  VAL VAL A . n 
A 1 216 LYS 216 221  221  LYS LYS A . n 
A 1 217 PHE 217 222  222  PHE PHE A . n 
A 1 218 SER 218 223  223  SER SER A . n 
A 1 219 PRO 219 224  224  PRO PRO A . n 
A 1 220 ASN 220 225  225  ASN ASN A . n 
A 1 221 GLY 221 226  226  GLY GLY A . n 
A 1 222 LYS 222 227  227  LYS LYS A . n 
A 1 223 TYR 223 228  228  TYR TYR A . n 
A 1 224 ILE 224 229  229  ILE ILE A . n 
A 1 225 LEU 225 230  230  LEU LEU A . n 
A 1 226 ALA 226 231  231  ALA ALA A . n 
A 1 227 ALA 227 232  232  ALA ALA A . n 
A 1 228 THR 228 233  233  THR THR A . n 
A 1 229 LEU 229 234  234  LEU LEU A . n 
A 1 230 ASP 230 235  235  ASP ASP A . n 
A 1 231 ASN 231 236  236  ASN ASN A . n 
A 1 232 THR 232 237  237  THR THR A . n 
A 1 233 LEU 233 238  238  LEU LEU A . n 
A 1 234 LYS 234 239  239  LYS LYS A . n 
A 1 235 LEU 235 240  240  LEU LEU A . n 
A 1 236 TRP 236 241  241  TRP TRP A . n 
A 1 237 ASP 237 242  242  ASP ASP A . n 
A 1 238 TYR 238 243  243  TYR TYR A . n 
A 1 239 SER 239 244  244  SER SER A . n 
A 1 240 LYS 240 245  245  LYS LYS A . n 
A 1 241 GLY 241 246  246  GLY GLY A . n 
A 1 242 LYS 242 247  247  LYS LYS A . n 
A 1 243 CYS 243 248  248  CYS CYS A . n 
A 1 244 LEU 244 249  249  LEU LEU A . n 
A 1 245 LYS 245 250  250  LYS LYS A . n 
A 1 246 THR 246 251  251  THR THR A . n 
A 1 247 TYR 247 252  252  TYR TYR A . n 
A 1 248 THR 248 253  253  THR THR A . n 
A 1 249 GLY 249 254  254  GLY GLY A . n 
A 1 250 HIS 250 255  255  HIS HIS A . n 
A 1 251 LYS 251 256  256  LYS LYS A . n 
A 1 252 ASN 252 257  257  ASN ASN A . n 
A 1 253 GLU 253 258  258  GLU GLU A . n 
A 1 254 LYS 254 259  259  LYS LYS A . n 
A 1 255 TYR 255 260  260  TYR TYR A . n 
A 1 256 CYS 256 261  261  CYS CYS A . n 
A 1 257 ILE 257 262  262  ILE ILE A . n 
A 1 258 PHE 258 263  263  PHE PHE A . n 
A 1 259 ALA 259 264  264  ALA ALA A . n 
A 1 260 ASN 260 265  265  ASN ASN A . n 
A 1 261 PHE 261 266  266  PHE PHE A . n 
A 1 262 SER 262 267  267  SER SER A . n 
A 1 263 VAL 263 268  268  VAL VAL A . n 
A 1 264 THR 264 269  269  THR THR A . n 
A 1 265 GLY 265 270  270  GLY GLY A . n 
A 1 266 GLY 266 271  271  GLY GLY A . n 
A 1 267 LYS 267 272  272  LYS LYS A . n 
A 1 268 TRP 268 273  273  TRP TRP A . n 
A 1 269 ILE 269 274  274  ILE ILE A . n 
A 1 270 VAL 270 275  275  VAL VAL A . n 
A 1 271 SER 271 276  276  SER SER A . n 
A 1 272 GLY 272 277  277  GLY GLY A . n 
A 1 273 SER 273 278  278  SER SER A . n 
A 1 274 GLU 274 279  279  GLU GLU A . n 
A 1 275 ASP 275 280  280  ASP ASP A . n 
A 1 276 ASN 276 281  281  ASN ASN A . n 
A 1 277 LEU 277 282  282  LEU LEU A . n 
A 1 278 VAL 278 283  283  VAL VAL A . n 
A 1 279 TYR 279 284  284  TYR TYR A . n 
A 1 280 ILE 280 285  285  ILE ILE A . n 
A 1 281 TRP 281 286  286  TRP TRP A . n 
A 1 282 ASN 282 287  287  ASN ASN A . n 
A 1 283 LEU 283 288  288  LEU LEU A . n 
A 1 284 GLN 284 289  289  GLN GLN A . n 
A 1 285 THR 285 290  290  THR THR A . n 
A 1 286 LYS 286 291  291  LYS LYS A . n 
A 1 287 GLU 287 292  292  GLU GLU A . n 
A 1 288 ILE 288 293  293  ILE ILE A . n 
A 1 289 VAL 289 294  294  VAL VAL A . n 
A 1 290 GLN 290 295  295  GLN GLN A . n 
A 1 291 LYS 291 296  296  LYS LYS A . n 
A 1 292 LEU 292 297  297  LEU LEU A . n 
A 1 293 GLN 293 298  298  GLN GLN A . n 
A 1 294 GLY 294 299  299  GLY GLY A . n 
A 1 295 HIS 295 300  300  HIS HIS A . n 
A 1 296 THR 296 301  301  THR THR A . n 
A 1 297 ASP 297 302  302  ASP ASP A . n 
A 1 298 VAL 298 303  303  VAL VAL A . n 
A 1 299 VAL 299 304  304  VAL VAL A . n 
A 1 300 ILE 300 305  305  ILE ILE A . n 
A 1 301 SER 301 306  306  SER SER A . n 
A 1 302 THR 302 307  307  THR THR A . n 
A 1 303 ALA 303 308  308  ALA ALA A . n 
A 1 304 CYS 304 309  309  CYS CYS A . n 
A 1 305 HIS 305 310  310  HIS HIS A . n 
A 1 306 PRO 306 311  311  PRO PRO A . n 
A 1 307 THR 307 312  312  THR THR A . n 
A 1 308 GLU 308 313  313  GLU GLU A . n 
A 1 309 ASN 309 314  314  ASN ASN A . n 
A 1 310 ILE 310 315  315  ILE ILE A . n 
A 1 311 ILE 311 316  316  ILE ILE A . n 
A 1 312 ALA 312 317  317  ALA ALA A . n 
A 1 313 SER 313 318  318  SER SER A . n 
A 1 314 ALA 314 319  319  ALA ALA A . n 
A 1 315 ALA 315 320  320  ALA ALA A . n 
A 1 316 LEU 316 321  321  LEU LEU A . n 
A 1 317 GLU 317 322  322  GLU GLU A . n 
A 1 318 ASN 318 323  323  ASN ASN A . n 
A 1 319 ASP 319 324  324  ASP ASP A . n 
A 1 320 LYS 320 325  325  LYS LYS A . n 
A 1 321 THR 321 326  326  THR THR A . n 
A 1 322 ILE 322 327  327  ILE ILE A . n 
A 1 323 LYS 323 328  328  LYS LYS A . n 
A 1 324 LEU 324 329  329  LEU LEU A . n 
A 1 325 TRP 325 330  330  TRP TRP A . n 
A 1 326 LYS 326 331  331  LYS LYS A . n 
A 1 327 SER 327 332  332  SER SER A . n 
A 1 328 ASP 328 333  333  ASP ASP A . n 
A 1 329 CYS 329 334  334  CYS CYS A . n 
B 2 1   MET 1   1053 ?    ?   ?   B . n 
B 2 2   GLY 2   1054 ?    ?   ?   B . n 
B 2 3   SER 3   1055 ?    ?   ?   B . n 
B 2 4   SER 4   1056 ?    ?   ?   B . n 
B 2 5   HIS 5   1057 ?    ?   ?   B . n 
B 2 6   HIS 6   1058 ?    ?   ?   B . n 
B 2 7   HIS 7   1059 ?    ?   ?   B . n 
B 2 8   HIS 8   1060 ?    ?   ?   B . n 
B 2 9   HIS 9   1061 ?    ?   ?   B . n 
B 2 10  HIS 10  1062 ?    ?   ?   B . n 
B 2 11  SER 11  1063 ?    ?   ?   B . n 
B 2 12  SER 12  1064 ?    ?   ?   B . n 
B 2 13  GLY 13  1065 ?    ?   ?   B . n 
B 2 14  ARG 14  1066 ?    ?   ?   B . n 
B 2 15  GLU 15  1067 ?    ?   ?   B . n 
B 2 16  ASN 16  1068 ?    ?   ?   B . n 
B 2 17  LEU 17  1069 ?    ?   ?   B . n 
B 2 18  TYR 18  1070 ?    ?   ?   B . n 
B 2 19  PHE 19  1071 ?    ?   ?   B . n 
B 2 20  GLN 20  1072 ?    ?   ?   B . n 
B 2 21  GLY 21  1073 ?    ?   ?   B . n 
B 2 22  SER 22  1074 ?    ?   ?   B . n 
B 2 23  SER 23  1075 ?    ?   ?   B . n 
B 2 24  ARG 24  1076 ?    ?   ?   B . n 
B 2 25  ALA 25  1077 ?    ?   ?   B . n 
B 2 26  SER 26  1078 ?    ?   ?   B . n 
B 2 27  ALA 27  1079 1079 ALA ALA B . n 
B 2 28  PHE 28  1080 1080 PHE PHE B . n 
B 2 29  ARG 29  1081 1081 ARG ARG B . n 
B 2 30  PRO 30  1082 1082 PRO PRO B . n 
B 2 31  ILE 31  1083 1083 ILE ILE B . n 
B 2 32  SER 32  1084 1084 SER SER B . n 
B 2 33  VAL 33  1085 1085 VAL VAL B . n 
B 2 34  PHE 34  1086 1086 PHE PHE B . n 
B 2 35  ARG 35  1087 1087 ARG ARG B . n 
B 2 36  GLU 36  1088 1088 GLU GLU B . n 
B 2 37  ALA 37  1089 1089 ALA ALA B . n 
B 2 38  ASN 38  1090 1090 ASN ASN B . n 
B 2 39  GLU 39  1091 1091 GLU GLU B . n 
B 2 40  ASP 40  1092 1092 ASP ASP B . n 
B 2 41  GLU 41  1093 1093 GLU GLU B . n 
B 2 42  SER 42  1094 1094 SER SER B . n 
B 2 43  GLY 43  1095 1095 GLY GLY B . n 
B 2 44  PHE 44  1096 1096 PHE PHE B . n 
B 2 45  THR 45  1097 1097 THR THR B . n 
B 2 46  CYS 46  1098 1098 CYS CYS B . n 
B 2 47  CYS 47  1099 1099 CYS CYS B . n 
B 2 48  ALA 48  1100 1100 ALA ALA B . n 
B 2 49  PHE 49  1101 1101 PHE PHE B . n 
B 2 50  SER 50  1102 1102 SER SER B . n 
B 2 51  ALA 51  1103 1103 ALA ALA B . n 
B 2 52  ARG 52  1104 1104 ARG ARG B . n 
B 2 53  GLU 53  1105 1105 GLU GLU B . n 
B 2 54  ARG 54  1106 1106 ARG ARG B . n 
B 2 55  PHE 55  1107 1107 PHE PHE B . n 
B 2 56  LEU 56  1108 1108 LEU LEU B . n 
B 2 57  MET 57  1109 1109 MET MET B . n 
B 2 58  LEU 58  1110 1110 LEU LEU B . n 
B 2 59  GLY 59  1111 1111 GLY GLY B . n 
B 2 60  THR 60  1112 1112 THR THR B . n 
B 2 61  CYS 61  1113 1113 CYS CYS B . n 
B 2 62  THR 62  1114 1114 THR THR B . n 
B 2 63  GLY 63  1115 1115 GLY GLY B . n 
B 2 64  GLN 64  1116 1116 GLN GLN B . n 
B 2 65  LEU 65  1117 1117 LEU LEU B . n 
B 2 66  LYS 66  1118 1118 LYS LYS B . n 
B 2 67  LEU 67  1119 1119 LEU LEU B . n 
B 2 68  TYR 68  1120 1120 TYR TYR B . n 
B 2 69  ASN 69  1121 1121 ASN ASN B . n 
B 2 70  VAL 70  1122 1122 VAL VAL B . n 
B 2 71  PHE 71  1123 1123 PHE PHE B . n 
B 2 72  SER 72  1124 1124 SER SER B . n 
B 2 73  GLY 73  1125 1125 GLY GLY B . n 
B 2 74  GLN 74  1126 1126 GLN GLN B . n 
B 2 75  GLU 75  1127 1127 GLU GLU B . n 
B 2 76  GLU 76  1128 1128 GLU GLU B . n 
B 2 77  ALA 77  1129 1129 ALA ALA B . n 
B 2 78  SER 78  1130 1130 SER SER B . n 
B 2 79  TYR 79  1131 1131 TYR TYR B . n 
B 2 80  ASN 80  1132 1132 ASN ASN B . n 
B 2 81  CYS 81  1133 1133 CYS CYS B . n 
B 2 82  HIS 82  1134 1134 HIS HIS B . n 
B 2 83  ASN 83  1135 1135 ASN ASN B . n 
B 2 84  SER 84  1136 1136 SER SER B . n 
B 2 85  ALA 85  1137 1137 ALA ALA B . n 
B 2 86  ILE 86  1138 1138 ILE ILE B . n 
B 2 87  THR 87  1139 1139 THR THR B . n 
B 2 88  HIS 88  1140 1140 HIS HIS B . n 
B 2 89  LEU 89  1141 1141 LEU LEU B . n 
B 2 90  GLU 90  1142 1142 GLU GLU B . n 
B 2 91  PRO 91  1143 1143 PRO PRO B . n 
B 2 92  SER 92  1144 1144 SER SER B . n 
B 2 93  ARG 93  1145 1145 ARG ARG B . n 
B 2 94  ASP 94  1146 1146 ASP ASP B . n 
B 2 95  GLY 95  1147 1147 GLY GLY B . n 
B 2 96  SER 96  1148 1148 SER SER B . n 
B 2 97  LEU 97  1149 1149 LEU LEU B . n 
B 2 98  LEU 98  1150 1150 LEU LEU B . n 
B 2 99  LEU 99  1151 1151 LEU LEU B . n 
B 2 100 THR 100 1152 1152 THR THR B . n 
B 2 101 SER 101 1153 1153 SER SER B . n 
B 2 102 ALA 102 1154 1154 ALA ALA B . n 
B 2 103 THR 103 1155 1155 THR THR B . n 
B 2 104 TRP 104 1156 1156 TRP TRP B . n 
B 2 105 SER 105 1157 1157 SER SER B . n 
B 2 106 GLN 106 1158 1158 GLN GLN B . n 
B 2 107 PRO 107 1159 1159 PRO PRO B . n 
B 2 108 LEU 108 1160 1160 LEU LEU B . n 
B 2 109 SER 109 1161 1161 SER SER B . n 
B 2 110 ALA 110 1162 1162 ALA ALA B . n 
B 2 111 LEU 111 1163 1163 LEU LEU B . n 
B 2 112 TRP 112 1164 1164 TRP TRP B . n 
B 2 113 GLY 113 1165 1165 GLY GLY B . n 
B 2 114 MET 114 1166 1166 MET MET B . n 
B 2 115 LYS 115 1167 1167 LYS LYS B . n 
B 2 116 SER 116 1168 1168 SER SER B . n 
B 2 117 VAL 117 1169 1169 VAL VAL B . n 
B 2 118 PHE 118 1170 1170 PHE PHE B . n 
B 2 119 ASP 119 1171 1171 ASP ASP B . n 
B 2 120 MET 120 1172 1172 MET MET B . n 
B 2 121 LYS 121 1173 1173 LYS LYS B . n 
B 2 122 HIS 122 1174 1174 HIS HIS B . n 
B 2 123 SER 123 1175 1175 SER SER B . n 
B 2 124 PHE 124 1176 1176 PHE PHE B . n 
B 2 125 THR 125 1177 1177 THR THR B . n 
B 2 126 GLU 126 1178 1178 GLU GLU B . n 
B 2 127 ASP 127 1179 1179 ASP ASP B . n 
B 2 128 HIS 128 1180 1180 HIS HIS B . n 
B 2 129 TYR 129 1181 1181 TYR TYR B . n 
B 2 130 VAL 130 1182 1182 VAL VAL B . n 
B 2 131 GLU 131 1183 1183 GLU GLU B . n 
B 2 132 PHE 132 1184 1184 PHE PHE B . n 
B 2 133 SER 133 1185 1185 SER SER B . n 
B 2 134 LYS 134 1186 1186 LYS LYS B . n 
B 2 135 HIS 135 1187 1187 HIS HIS B . n 
B 2 136 SER 136 1188 1188 SER SER B . n 
B 2 137 GLN 137 1189 1189 GLN GLN B . n 
B 2 138 ASP 138 1190 1190 ASP ASP B . n 
B 2 139 ARG 139 1191 1191 ARG ARG B . n 
B 2 140 VAL 140 1192 1192 VAL VAL B . n 
B 2 141 ILE 141 1193 1193 ILE ILE B . n 
B 2 142 GLY 142 1194 1194 GLY GLY B . n 
B 2 143 THR 143 1195 1195 THR THR B . n 
B 2 144 LYS 144 1196 1196 LYS LYS B . n 
B 2 145 GLY 145 1197 1197 GLY GLY B . n 
B 2 146 ASP 146 1198 1198 ASP ASP B . n 
B 2 147 ILE 147 1199 1199 ILE ILE B . n 
B 2 148 ALA 148 1200 1200 ALA ALA B . n 
B 2 149 HIS 149 1201 1201 HIS HIS B . n 
B 2 150 ILE 150 1202 1202 ILE ILE B . n 
B 2 151 TYR 151 1203 1203 TYR TYR B . n 
B 2 152 ASP 152 1204 1204 ASP ASP B . n 
B 2 153 ILE 153 1205 1205 ILE ILE B . n 
B 2 154 GLN 154 1206 1206 GLN GLN B . n 
B 2 155 THR 155 1207 1207 THR THR B . n 
B 2 156 GLY 156 1208 1208 GLY GLY B . n 
B 2 157 ASN 157 1209 1209 ASN ASN B . n 
B 2 158 LYS 158 1210 1210 LYS LYS B . n 
B 2 159 LEU 159 1211 1211 LEU LEU B . n 
B 2 160 LEU 160 1212 1212 LEU LEU B . n 
B 2 161 THR 161 1213 1213 THR THR B . n 
B 2 162 LEU 162 1214 1214 LEU LEU B . n 
B 2 163 PHE 163 1215 1215 PHE PHE B . n 
B 2 164 ASN 164 1216 1216 ASN ASN B . n 
B 2 165 PRO 165 1217 1217 PRO PRO B . n 
B 2 166 ASP 166 1218 1218 ASP ASP B . n 
B 2 167 LEU 167 1219 1219 LEU LEU B . n 
B 2 168 ALA 168 1220 1220 ALA ALA B . n 
B 2 169 ASN 169 1221 1221 ASN ASN B . n 
B 2 170 ASN 170 1222 1222 ASN ASN B . n 
B 2 171 TYR 171 1223 1223 TYR TYR B . n 
B 2 172 LYS 172 1224 1224 LYS LYS B . n 
B 2 173 ARG 173 1225 1225 ARG ARG B . n 
B 2 174 ASN 174 1226 1226 ASN ASN B . n 
B 2 175 CYS 175 1227 1227 CYS CYS B . n 
B 2 176 ALA 176 1228 1228 ALA ALA B . n 
B 2 177 THR 177 1229 1229 THR THR B . n 
B 2 178 PHE 178 1230 1230 PHE PHE B . n 
B 2 179 ASN 179 1231 1231 ASN ASN B . n 
B 2 180 PRO 180 1232 1232 PRO PRO B . n 
B 2 181 THR 181 1233 1233 THR THR B . n 
B 2 182 ASP 182 1234 1234 ASP ASP B . n 
B 2 183 ASP 183 1235 1235 ASP ASP B . n 
B 2 184 LEU 184 1236 1236 LEU LEU B . n 
B 2 185 VAL 185 1237 1237 VAL VAL B . n 
B 2 186 LEU 186 1238 1238 LEU LEU B . n 
B 2 187 ASN 187 1239 1239 ASN ASN B . n 
B 2 188 ASP 188 1240 1240 ASP ASP B . n 
B 2 189 GLY 189 1241 1241 GLY GLY B . n 
B 2 190 VAL 190 1242 1242 VAL VAL B . n 
B 2 191 LEU 191 1243 1243 LEU LEU B . n 
B 2 192 TRP 192 1244 1244 TRP TRP B . n 
B 2 193 ASP 193 1245 1245 ASP ASP B . n 
B 2 194 VAL 194 1246 1246 VAL VAL B . n 
B 2 195 ARG 195 1247 1247 ARG ARG B . n 
B 2 196 SER 196 1248 1248 SER SER B . n 
B 2 197 ALA 197 1249 1249 ALA ALA B . n 
B 2 198 GLN 198 1250 1250 GLN GLN B . n 
B 2 199 ALA 199 1251 1251 ALA ALA B . n 
B 2 200 ILE 200 1252 1252 ILE ILE B . n 
B 2 201 HIS 201 1253 1253 HIS HIS B . n 
B 2 202 LYS 202 1254 1254 LYS LYS B . n 
B 2 203 PHE 203 1255 1255 PHE PHE B . n 
B 2 204 ASP 204 1256 1256 ASP ASP B . n 
B 2 205 LYS 205 1257 1257 LYS LYS B . n 
B 2 206 PHE 206 1258 1258 PHE PHE B . n 
B 2 207 ASN 207 1259 1259 ASN ASN B . n 
B 2 208 MET 208 1260 1260 MET MET B . n 
B 2 209 ASN 209 1261 1261 ASN ASN B . n 
B 2 210 ILE 210 1262 1262 ILE ILE B . n 
B 2 211 SER 211 1263 1263 SER SER B . n 
B 2 212 GLY 212 1264 1264 GLY GLY B . n 
B 2 213 VAL 213 1265 1265 VAL VAL B . n 
B 2 214 PHE 214 1266 1266 PHE PHE B . n 
B 2 215 HIS 215 1267 1267 HIS HIS B . n 
B 2 216 PRO 216 1268 1268 PRO PRO B . n 
B 2 217 ASN 217 1269 1269 ASN ASN B . n 
B 2 218 GLY 218 1270 1270 GLY GLY B . n 
B 2 219 LEU 219 1271 1271 LEU LEU B . n 
B 2 220 GLU 220 1272 1272 GLU GLU B . n 
B 2 221 VAL 221 1273 1273 VAL VAL B . n 
B 2 222 ILE 222 1274 1274 ILE ILE B . n 
B 2 223 ILE 223 1275 1275 ILE ILE B . n 
B 2 224 ASN 224 1276 1276 ASN ASN B . n 
B 2 225 THR 225 1277 1277 THR THR B . n 
B 2 226 GLU 226 1278 1278 GLU GLU B . n 
B 2 227 ILE 227 1279 1279 ILE ILE B . n 
B 2 228 TRP 228 1280 1280 TRP TRP B . n 
B 2 229 ASP 229 1281 1281 ASP ASP B . n 
B 2 230 LEU 230 1282 1282 LEU LEU B . n 
B 2 231 ARG 231 1283 1283 ARG ARG B . n 
B 2 232 THR 232 1284 1284 THR THR B . n 
B 2 233 PHE 233 1285 1285 PHE PHE B . n 
B 2 234 HIS 234 1286 1286 HIS HIS B . n 
B 2 235 LEU 235 1287 1287 LEU LEU B . n 
B 2 236 LEU 236 1288 1288 LEU LEU B . n 
B 2 237 HIS 237 1289 1289 HIS HIS B . n 
B 2 238 THR 238 1290 1290 THR THR B . n 
B 2 239 VAL 239 1291 1291 VAL VAL B . n 
B 2 240 PRO 240 1292 1292 PRO PRO B . n 
B 2 241 ALA 241 1293 1293 ALA ALA B . n 
B 2 242 LEU 242 1294 1294 LEU LEU B . n 
B 2 243 ASP 243 1295 1295 ASP ASP B . n 
B 2 244 GLN 244 1296 1296 GLN GLN B . n 
B 2 245 CYS 245 1297 1297 CYS CYS B . n 
B 2 246 ARG 246 1298 1298 ARG ARG B . n 
B 2 247 VAL 247 1299 1299 VAL VAL B . n 
B 2 248 VAL 248 1300 1300 VAL VAL B . n 
B 2 249 PHE 249 1301 1301 PHE PHE B . n 
B 2 250 ASN 250 1302 1302 ASN ASN B . n 
B 2 251 HIS 251 1303 1303 HIS HIS B . n 
B 2 252 THR 252 1304 1304 THR THR B . n 
B 2 253 GLY 253 1305 1305 GLY GLY B . n 
B 2 254 THR 254 1306 1306 THR THR B . n 
B 2 255 VAL 255 1307 1307 VAL VAL B . n 
B 2 256 MET 256 1308 1308 MET MET B . n 
B 2 257 TYR 257 1309 1309 TYR TYR B . n 
B 2 258 GLY 258 1310 1310 GLY GLY B . n 
B 2 259 ALA 259 1311 1311 ALA ALA B . n 
B 2 260 MET 260 1312 1312 MET MET B . n 
B 2 261 LEU 261 1313 1313 LEU LEU B . n 
B 2 262 GLN 262 1314 1314 GLN GLN B . n 
B 2 263 ALA 263 1315 1315 ALA ALA B . n 
B 2 264 ASP 264 1316 1316 ASP ASP B . n 
B 2 265 ASP 265 1317 ?    ?   ?   B . n 
B 2 266 GLU 266 1318 ?    ?   ?   B . n 
B 2 267 ASP 267 1319 ?    ?   ?   B . n 
B 2 268 ASP 268 1320 ?    ?   ?   B . n 
B 2 269 LEU 269 1321 1321 LEU LEU B . n 
B 2 270 MET 270 1322 1322 MET MET B . n 
B 2 271 GLU 271 1323 1323 GLU GLU B . n 
B 2 272 GLU 272 1324 1324 GLU GLU B . n 
B 2 273 ARG 273 1325 1325 ARG ARG B . n 
B 2 274 MET 274 1326 1326 MET MET B . n 
B 2 275 LYS 275 1327 1327 LYS LYS B . n 
B 2 276 SER 276 1328 1328 SER SER B . n 
B 2 277 PRO 277 1329 1329 PRO PRO B . n 
B 2 278 PHE 278 1330 1330 PHE PHE B . n 
B 2 279 GLY 279 1331 1331 GLY GLY B . n 
B 2 280 SER 280 1332 1332 SER SER B . n 
B 2 281 SER 281 1333 1333 SER SER B . n 
B 2 282 PHE 282 1334 1334 PHE PHE B . n 
B 2 283 ARG 283 1335 1335 ARG ARG B . n 
B 2 284 THR 284 1336 1336 THR THR B . n 
B 2 285 PHE 285 1337 1337 PHE PHE B . n 
B 2 286 ASN 286 1338 1338 ASN ASN B . n 
B 2 287 ALA 287 1339 1339 ALA ALA B . n 
B 2 288 THR 288 1340 1340 THR THR B . n 
B 2 289 ASP 289 1341 1341 ASP ASP B . n 
B 2 290 TYR 290 1342 1342 TYR TYR B . n 
B 2 291 LYS 291 1343 1343 LYS LYS B . n 
B 2 292 PRO 292 1344 1344 PRO PRO B . n 
B 2 293 ILE 293 1345 1345 ILE ILE B . n 
B 2 294 ALA 294 1346 1346 ALA ALA B . n 
B 2 295 THR 295 1347 1347 THR THR B . n 
B 2 296 ILE 296 1348 1348 ILE ILE B . n 
B 2 297 ASP 297 1349 1349 ASP ASP B . n 
B 2 298 VAL 298 1350 1350 VAL VAL B . n 
B 2 299 LYS 299 1351 1351 LYS LYS B . n 
B 2 300 ARG 300 1352 1352 ARG ARG B . n 
B 2 301 ASN 301 1353 1353 ASN ASN B . n 
B 2 302 ILE 302 1354 1354 ILE ILE B . n 
B 2 303 PHE 303 1355 1355 PHE PHE B . n 
B 2 304 ASP 304 1356 1356 ASP ASP B . n 
B 2 305 LEU 305 1357 1357 LEU LEU B . n 
B 2 306 CYS 306 1358 1358 CYS CYS B . n 
B 2 307 THR 307 1359 1359 THR THR B . n 
B 2 308 ASP 308 1360 1360 ASP ASP B . n 
B 2 309 THR 309 1361 1361 THR THR B . n 
B 2 310 LYS 310 1362 1362 LYS LYS B . n 
B 2 311 ASP 311 1363 1363 ASP ASP B . n 
B 2 312 CYS 312 1364 1364 CYS CYS B . n 
B 2 313 TYR 313 1365 1365 TYR TYR B . n 
B 2 314 LEU 314 1366 1366 LEU LEU B . n 
B 2 315 ALA 315 1367 1367 ALA ALA B . n 
B 2 316 VAL 316 1368 1368 VAL VAL B . n 
B 2 317 ILE 317 1369 1369 ILE ILE B . n 
B 2 318 GLU 318 1370 1370 GLU GLU B . n 
B 2 319 ASN 319 1371 1371 ASN ASN B . n 
B 2 320 GLN 320 1372 1372 GLN GLN B . n 
B 2 321 GLY 321 1373 1373 GLY GLY B . n 
B 2 322 SER 322 1374 ?    ?   ?   B . n 
B 2 323 MET 323 1375 ?    ?   ?   B . n 
B 2 324 ASP 324 1376 ?    ?   ?   B . n 
B 2 325 ALA 325 1377 ?    ?   ?   B . n 
B 2 326 LEU 326 1378 ?    ?   ?   B . n 
B 2 327 ASN 327 1379 1379 ASN ASN B . n 
B 2 328 MET 328 1380 1380 MET MET B . n 
B 2 329 ASP 329 1381 1381 ASP ASP B . n 
B 2 330 THR 330 1382 1382 THR THR B . n 
B 2 331 VAL 331 1383 1383 VAL VAL B . n 
B 2 332 CYS 332 1384 1384 CYS CYS B . n 
B 2 333 ARG 333 1385 1385 ARG ARG B . n 
B 2 334 LEU 334 1386 1386 LEU LEU B . n 
B 2 335 TYR 335 1387 1387 TYR TYR B . n 
B 2 336 GLU 336 1388 1388 GLU GLU B . n 
B 2 337 VAL 337 1389 1389 VAL VAL B . n 
B 2 338 GLY 338 1390 1390 GLY GLY B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1ANM 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1ANM 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 A1ANM 1   1401 1401 A1ANM UNK A . 
D 4 HOH   1   1501 194  HOH   HOH A . 
D 4 HOH   2   1502 490  HOH   HOH A . 
D 4 HOH   3   1503 222  HOH   HOH A . 
D 4 HOH   4   1504 537  HOH   HOH A . 
D 4 HOH   5   1505 340  HOH   HOH A . 
D 4 HOH   6   1506 241  HOH   HOH A . 
D 4 HOH   7   1507 350  HOH   HOH A . 
D 4 HOH   8   1508 43   HOH   HOH A . 
D 4 HOH   9   1509 280  HOH   HOH A . 
D 4 HOH   10  1510 310  HOH   HOH A . 
D 4 HOH   11  1511 203  HOH   HOH A . 
D 4 HOH   12  1512 335  HOH   HOH A . 
D 4 HOH   13  1513 577  HOH   HOH A . 
D 4 HOH   14  1514 34   HOH   HOH A . 
D 4 HOH   15  1515 158  HOH   HOH A . 
D 4 HOH   16  1516 97   HOH   HOH A . 
D 4 HOH   17  1517 599  HOH   HOH A . 
D 4 HOH   18  1518 111  HOH   HOH A . 
D 4 HOH   19  1519 109  HOH   HOH A . 
D 4 HOH   20  1520 217  HOH   HOH A . 
D 4 HOH   21  1521 507  HOH   HOH A . 
D 4 HOH   22  1522 142  HOH   HOH A . 
D 4 HOH   23  1523 242  HOH   HOH A . 
D 4 HOH   24  1524 10   HOH   HOH A . 
D 4 HOH   25  1525 533  HOH   HOH A . 
D 4 HOH   26  1526 44   HOH   HOH A . 
D 4 HOH   27  1527 70   HOH   HOH A . 
D 4 HOH   28  1528 488  HOH   HOH A . 
D 4 HOH   29  1529 87   HOH   HOH A . 
D 4 HOH   30  1530 397  HOH   HOH A . 
D 4 HOH   31  1531 220  HOH   HOH A . 
D 4 HOH   32  1532 441  HOH   HOH A . 
D 4 HOH   33  1533 54   HOH   HOH A . 
D 4 HOH   34  1534 169  HOH   HOH A . 
D 4 HOH   35  1535 407  HOH   HOH A . 
D 4 HOH   36  1536 202  HOH   HOH A . 
D 4 HOH   37  1537 422  HOH   HOH A . 
D 4 HOH   38  1538 348  HOH   HOH A . 
D 4 HOH   39  1539 13   HOH   HOH A . 
D 4 HOH   40  1540 91   HOH   HOH A . 
D 4 HOH   41  1541 2    HOH   HOH A . 
D 4 HOH   42  1542 387  HOH   HOH A . 
D 4 HOH   43  1543 333  HOH   HOH A . 
D 4 HOH   44  1544 170  HOH   HOH A . 
D 4 HOH   45  1545 388  HOH   HOH A . 
D 4 HOH   46  1546 195  HOH   HOH A . 
D 4 HOH   47  1547 269  HOH   HOH A . 
D 4 HOH   48  1548 595  HOH   HOH A . 
D 4 HOH   49  1549 53   HOH   HOH A . 
D 4 HOH   50  1550 185  HOH   HOH A . 
D 4 HOH   51  1551 55   HOH   HOH A . 
D 4 HOH   52  1552 86   HOH   HOH A . 
D 4 HOH   53  1553 237  HOH   HOH A . 
D 4 HOH   54  1554 33   HOH   HOH A . 
D 4 HOH   55  1555 113  HOH   HOH A . 
D 4 HOH   56  1556 22   HOH   HOH A . 
D 4 HOH   57  1557 96   HOH   HOH A . 
D 4 HOH   58  1558 444  HOH   HOH A . 
D 4 HOH   59  1559 128  HOH   HOH A . 
D 4 HOH   60  1560 16   HOH   HOH A . 
D 4 HOH   61  1561 275  HOH   HOH A . 
D 4 HOH   62  1562 265  HOH   HOH A . 
D 4 HOH   63  1563 286  HOH   HOH A . 
D 4 HOH   64  1564 57   HOH   HOH A . 
D 4 HOH   65  1565 432  HOH   HOH A . 
D 4 HOH   66  1566 130  HOH   HOH A . 
D 4 HOH   67  1567 1    HOH   HOH A . 
D 4 HOH   68  1568 306  HOH   HOH A . 
D 4 HOH   69  1569 6    HOH   HOH A . 
D 4 HOH   70  1570 298  HOH   HOH A . 
D 4 HOH   71  1571 132  HOH   HOH A . 
D 4 HOH   72  1572 93   HOH   HOH A . 
D 4 HOH   73  1573 31   HOH   HOH A . 
D 4 HOH   74  1574 105  HOH   HOH A . 
D 4 HOH   75  1575 76   HOH   HOH A . 
D 4 HOH   76  1576 365  HOH   HOH A . 
D 4 HOH   77  1577 411  HOH   HOH A . 
D 4 HOH   78  1578 436  HOH   HOH A . 
D 4 HOH   79  1579 50   HOH   HOH A . 
D 4 HOH   80  1580 439  HOH   HOH A . 
D 4 HOH   81  1581 492  HOH   HOH A . 
D 4 HOH   82  1582 64   HOH   HOH A . 
D 4 HOH   83  1583 60   HOH   HOH A . 
D 4 HOH   84  1584 224  HOH   HOH A . 
D 4 HOH   85  1585 320  HOH   HOH A . 
D 4 HOH   86  1586 229  HOH   HOH A . 
D 4 HOH   87  1587 196  HOH   HOH A . 
D 4 HOH   88  1588 23   HOH   HOH A . 
D 4 HOH   89  1589 254  HOH   HOH A . 
D 4 HOH   90  1590 15   HOH   HOH A . 
D 4 HOH   91  1591 104  HOH   HOH A . 
D 4 HOH   92  1592 346  HOH   HOH A . 
D 4 HOH   93  1593 230  HOH   HOH A . 
D 4 HOH   94  1594 342  HOH   HOH A . 
D 4 HOH   95  1595 165  HOH   HOH A . 
D 4 HOH   96  1596 157  HOH   HOH A . 
D 4 HOH   97  1597 56   HOH   HOH A . 
D 4 HOH   98  1598 46   HOH   HOH A . 
D 4 HOH   99  1599 232  HOH   HOH A . 
D 4 HOH   100 1600 520  HOH   HOH A . 
D 4 HOH   101 1601 207  HOH   HOH A . 
D 4 HOH   102 1602 18   HOH   HOH A . 
D 4 HOH   103 1603 244  HOH   HOH A . 
D 4 HOH   104 1604 92   HOH   HOH A . 
D 4 HOH   105 1605 566  HOH   HOH A . 
D 4 HOH   106 1606 49   HOH   HOH A . 
D 4 HOH   107 1607 126  HOH   HOH A . 
D 4 HOH   108 1608 219  HOH   HOH A . 
D 4 HOH   109 1609 153  HOH   HOH A . 
D 4 HOH   110 1610 145  HOH   HOH A . 
D 4 HOH   111 1611 546  HOH   HOH A . 
D 4 HOH   112 1612 159  HOH   HOH A . 
D 4 HOH   113 1613 401  HOH   HOH A . 
D 4 HOH   114 1614 28   HOH   HOH A . 
D 4 HOH   115 1615 141  HOH   HOH A . 
D 4 HOH   116 1616 161  HOH   HOH A . 
D 4 HOH   117 1617 124  HOH   HOH A . 
D 4 HOH   118 1618 134  HOH   HOH A . 
D 4 HOH   119 1619 283  HOH   HOH A . 
D 4 HOH   120 1620 552  HOH   HOH A . 
D 4 HOH   121 1621 66   HOH   HOH A . 
D 4 HOH   122 1622 129  HOH   HOH A . 
D 4 HOH   123 1623 14   HOH   HOH A . 
D 4 HOH   124 1624 568  HOH   HOH A . 
D 4 HOH   125 1625 589  HOH   HOH A . 
D 4 HOH   126 1626 38   HOH   HOH A . 
D 4 HOH   127 1627 75   HOH   HOH A . 
D 4 HOH   128 1628 337  HOH   HOH A . 
D 4 HOH   129 1629 519  HOH   HOH A . 
D 4 HOH   130 1630 127  HOH   HOH A . 
D 4 HOH   131 1631 106  HOH   HOH A . 
D 4 HOH   132 1632 45   HOH   HOH A . 
D 4 HOH   133 1633 344  HOH   HOH A . 
D 4 HOH   134 1634 187  HOH   HOH A . 
D 4 HOH   135 1635 20   HOH   HOH A . 
D 4 HOH   136 1636 110  HOH   HOH A . 
D 4 HOH   137 1637 479  HOH   HOH A . 
D 4 HOH   138 1638 359  HOH   HOH A . 
D 4 HOH   139 1639 100  HOH   HOH A . 
D 4 HOH   140 1640 256  HOH   HOH A . 
D 4 HOH   141 1641 378  HOH   HOH A . 
D 4 HOH   142 1642 259  HOH   HOH A . 
D 4 HOH   143 1643 197  HOH   HOH A . 
D 4 HOH   144 1644 227  HOH   HOH A . 
D 4 HOH   145 1645 557  HOH   HOH A . 
D 4 HOH   146 1646 512  HOH   HOH A . 
D 4 HOH   147 1647 65   HOH   HOH A . 
D 4 HOH   148 1648 278  HOH   HOH A . 
D 4 HOH   149 1649 290  HOH   HOH A . 
D 4 HOH   150 1650 281  HOH   HOH A . 
D 4 HOH   151 1651 412  HOH   HOH A . 
D 4 HOH   152 1652 392  HOH   HOH A . 
D 4 HOH   153 1653 140  HOH   HOH A . 
D 4 HOH   154 1654 547  HOH   HOH A . 
D 4 HOH   155 1655 95   HOH   HOH A . 
D 4 HOH   156 1656 215  HOH   HOH A . 
D 4 HOH   157 1657 200  HOH   HOH A . 
D 4 HOH   158 1658 367  HOH   HOH A . 
D 4 HOH   159 1659 154  HOH   HOH A . 
D 4 HOH   160 1660 277  HOH   HOH A . 
D 4 HOH   161 1661 515  HOH   HOH A . 
D 4 HOH   162 1662 162  HOH   HOH A . 
D 4 HOH   163 1663 358  HOH   HOH A . 
D 4 HOH   164 1664 364  HOH   HOH A . 
D 4 HOH   165 1665 292  HOH   HOH A . 
D 4 HOH   166 1666 29   HOH   HOH A . 
D 4 HOH   167 1667 361  HOH   HOH A . 
D 4 HOH   168 1668 218  HOH   HOH A . 
D 4 HOH   169 1669 213  HOH   HOH A . 
D 4 HOH   170 1670 522  HOH   HOH A . 
D 4 HOH   171 1671 602  HOH   HOH A . 
D 4 HOH   172 1672 464  HOH   HOH A . 
D 4 HOH   173 1673 591  HOH   HOH A . 
D 4 HOH   174 1674 445  HOH   HOH A . 
D 4 HOH   175 1675 112  HOH   HOH A . 
D 4 HOH   176 1676 314  HOH   HOH A . 
D 4 HOH   177 1677 318  HOH   HOH A . 
D 4 HOH   178 1678 300  HOH   HOH A . 
D 4 HOH   179 1679 59   HOH   HOH A . 
D 4 HOH   180 1680 355  HOH   HOH A . 
D 4 HOH   181 1681 390  HOH   HOH A . 
D 4 HOH   182 1682 442  HOH   HOH A . 
D 4 HOH   183 1683 328  HOH   HOH A . 
D 4 HOH   184 1684 324  HOH   HOH A . 
D 4 HOH   185 1685 379  HOH   HOH A . 
D 4 HOH   186 1686 452  HOH   HOH A . 
D 4 HOH   187 1687 338  HOH   HOH A . 
D 4 HOH   188 1688 466  HOH   HOH A . 
D 4 HOH   189 1689 190  HOH   HOH A . 
D 4 HOH   190 1690 312  HOH   HOH A . 
D 4 HOH   191 1691 73   HOH   HOH A . 
D 4 HOH   192 1692 500  HOH   HOH A . 
D 4 HOH   193 1693 517  HOH   HOH A . 
D 4 HOH   194 1694 114  HOH   HOH A . 
D 4 HOH   195 1695 294  HOH   HOH A . 
D 4 HOH   196 1696 446  HOH   HOH A . 
D 4 HOH   197 1697 582  HOH   HOH A . 
D 4 HOH   198 1698 597  HOH   HOH A . 
D 4 HOH   199 1699 433  HOH   HOH A . 
D 4 HOH   200 1700 72   HOH   HOH A . 
D 4 HOH   201 1701 504  HOH   HOH A . 
D 4 HOH   202 1702 534  HOH   HOH A . 
D 4 HOH   203 1703 427  HOH   HOH A . 
D 4 HOH   204 1704 349  HOH   HOH A . 
D 4 HOH   205 1705 549  HOH   HOH A . 
D 4 HOH   206 1706 240  HOH   HOH A . 
D 4 HOH   207 1707 181  HOH   HOH A . 
D 4 HOH   208 1708 417  HOH   HOH A . 
D 4 HOH   209 1709 545  HOH   HOH A . 
D 4 HOH   210 1710 251  HOH   HOH A . 
D 4 HOH   211 1711 543  HOH   HOH A . 
D 4 HOH   212 1712 368  HOH   HOH A . 
D 4 HOH   213 1713 516  HOH   HOH A . 
D 4 HOH   214 1714 386  HOH   HOH A . 
D 4 HOH   215 1715 354  HOH   HOH A . 
D 4 HOH   216 1716 289  HOH   HOH A . 
D 4 HOH   217 1717 143  HOH   HOH A . 
D 4 HOH   218 1718 363  HOH   HOH A . 
D 4 HOH   219 1719 179  HOH   HOH A . 
D 4 HOH   220 1720 382  HOH   HOH A . 
D 4 HOH   221 1721 252  HOH   HOH A . 
D 4 HOH   222 1722 581  HOH   HOH A . 
D 4 HOH   223 1723 332  HOH   HOH A . 
D 4 HOH   224 1724 258  HOH   HOH A . 
D 4 HOH   225 1725 226  HOH   HOH A . 
D 4 HOH   226 1726 383  HOH   HOH A . 
D 4 HOH   227 1727 447  HOH   HOH A . 
D 4 HOH   228 1728 146  HOH   HOH A . 
D 4 HOH   229 1729 419  HOH   HOH A . 
D 4 HOH   230 1730 559  HOH   HOH A . 
D 4 HOH   231 1731 234  HOH   HOH A . 
D 4 HOH   232 1732 192  HOH   HOH A . 
D 4 HOH   233 1733 483  HOH   HOH A . 
D 4 HOH   234 1734 561  HOH   HOH A . 
D 4 HOH   235 1735 341  HOH   HOH A . 
D 4 HOH   236 1736 400  HOH   HOH A . 
D 4 HOH   237 1737 139  HOH   HOH A . 
D 4 HOH   238 1738 212  HOH   HOH A . 
D 4 HOH   239 1739 564  HOH   HOH A . 
D 4 HOH   240 1740 539  HOH   HOH A . 
D 4 HOH   241 1741 323  HOH   HOH A . 
D 4 HOH   242 1742 270  HOH   HOH A . 
D 4 HOH   243 1743 247  HOH   HOH A . 
D 4 HOH   244 1744 331  HOH   HOH A . 
D 4 HOH   245 1745 467  HOH   HOH A . 
D 4 HOH   246 1746 360  HOH   HOH A . 
D 4 HOH   247 1747 505  HOH   HOH A . 
D 4 HOH   248 1748 465  HOH   HOH A . 
D 4 HOH   249 1749 491  HOH   HOH A . 
D 4 HOH   250 1750 497  HOH   HOH A . 
D 4 HOH   251 1751 588  HOH   HOH A . 
D 4 HOH   252 1752 528  HOH   HOH A . 
E 4 HOH   1   1401 456  HOH   HOH B . 
E 4 HOH   2   1402 156  HOH   HOH B . 
E 4 HOH   3   1403 245  HOH   HOH B . 
E 4 HOH   4   1404 279  HOH   HOH B . 
E 4 HOH   5   1405 147  HOH   HOH B . 
E 4 HOH   6   1406 371  HOH   HOH B . 
E 4 HOH   7   1407 562  HOH   HOH B . 
E 4 HOH   8   1408 609  HOH   HOH B . 
E 4 HOH   9   1409 370  HOH   HOH B . 
E 4 HOH   10  1410 544  HOH   HOH B . 
E 4 HOH   11  1411 11   HOH   HOH B . 
E 4 HOH   12  1412 120  HOH   HOH B . 
E 4 HOH   13  1413 61   HOH   HOH B . 
E 4 HOH   14  1414 303  HOH   HOH B . 
E 4 HOH   15  1415 71   HOH   HOH B . 
E 4 HOH   16  1416 514  HOH   HOH B . 
E 4 HOH   17  1417 8    HOH   HOH B . 
E 4 HOH   18  1418 184  HOH   HOH B . 
E 4 HOH   19  1419 7    HOH   HOH B . 
E 4 HOH   20  1420 454  HOH   HOH B . 
E 4 HOH   21  1421 186  HOH   HOH B . 
E 4 HOH   22  1422 406  HOH   HOH B . 
E 4 HOH   23  1423 583  HOH   HOH B . 
E 4 HOH   24  1424 250  HOH   HOH B . 
E 4 HOH   25  1425 339  HOH   HOH B . 
E 4 HOH   26  1426 216  HOH   HOH B . 
E 4 HOH   27  1427 81   HOH   HOH B . 
E 4 HOH   28  1428 189  HOH   HOH B . 
E 4 HOH   29  1429 295  HOH   HOH B . 
E 4 HOH   30  1430 36   HOH   HOH B . 
E 4 HOH   31  1431 531  HOH   HOH B . 
E 4 HOH   32  1432 263  HOH   HOH B . 
E 4 HOH   33  1433 214  HOH   HOH B . 
E 4 HOH   34  1434 243  HOH   HOH B . 
E 4 HOH   35  1435 607  HOH   HOH B . 
E 4 HOH   36  1436 5    HOH   HOH B . 
E 4 HOH   37  1437 102  HOH   HOH B . 
E 4 HOH   38  1438 478  HOH   HOH B . 
E 4 HOH   39  1439 380  HOH   HOH B . 
E 4 HOH   40  1440 352  HOH   HOH B . 
E 4 HOH   41  1441 137  HOH   HOH B . 
E 4 HOH   42  1442 77   HOH   HOH B . 
E 4 HOH   43  1443 334  HOH   HOH B . 
E 4 HOH   44  1444 311  HOH   HOH B . 
E 4 HOH   45  1445 83   HOH   HOH B . 
E 4 HOH   46  1446 150  HOH   HOH B . 
E 4 HOH   47  1447 131  HOH   HOH B . 
E 4 HOH   48  1448 82   HOH   HOH B . 
E 4 HOH   49  1449 133  HOH   HOH B . 
E 4 HOH   50  1450 168  HOH   HOH B . 
E 4 HOH   51  1451 174  HOH   HOH B . 
E 4 HOH   52  1452 3    HOH   HOH B . 
E 4 HOH   53  1453 32   HOH   HOH B . 
E 4 HOH   54  1454 489  HOH   HOH B . 
E 4 HOH   55  1455 25   HOH   HOH B . 
E 4 HOH   56  1456 62   HOH   HOH B . 
E 4 HOH   57  1457 287  HOH   HOH B . 
E 4 HOH   58  1458 253  HOH   HOH B . 
E 4 HOH   59  1459 600  HOH   HOH B . 
E 4 HOH   60  1460 449  HOH   HOH B . 
E 4 HOH   61  1461 19   HOH   HOH B . 
E 4 HOH   62  1462 69   HOH   HOH B . 
E 4 HOH   63  1463 9    HOH   HOH B . 
E 4 HOH   64  1464 554  HOH   HOH B . 
E 4 HOH   65  1465 115  HOH   HOH B . 
E 4 HOH   66  1466 39   HOH   HOH B . 
E 4 HOH   67  1467 225  HOH   HOH B . 
E 4 HOH   68  1468 74   HOH   HOH B . 
E 4 HOH   69  1469 415  HOH   HOH B . 
E 4 HOH   70  1470 47   HOH   HOH B . 
E 4 HOH   71  1471 273  HOH   HOH B . 
E 4 HOH   72  1472 4    HOH   HOH B . 
E 4 HOH   73  1473 257  HOH   HOH B . 
E 4 HOH   74  1474 37   HOH   HOH B . 
E 4 HOH   75  1475 21   HOH   HOH B . 
E 4 HOH   76  1476 151  HOH   HOH B . 
E 4 HOH   77  1477 35   HOH   HOH B . 
E 4 HOH   78  1478 26   HOH   HOH B . 
E 4 HOH   79  1479 199  HOH   HOH B . 
E 4 HOH   80  1480 570  HOH   HOH B . 
E 4 HOH   81  1481 85   HOH   HOH B . 
E 4 HOH   82  1482 52   HOH   HOH B . 
E 4 HOH   83  1483 79   HOH   HOH B . 
E 4 HOH   84  1484 481  HOH   HOH B . 
E 4 HOH   85  1485 17   HOH   HOH B . 
E 4 HOH   86  1486 499  HOH   HOH B . 
E 4 HOH   87  1487 117  HOH   HOH B . 
E 4 HOH   88  1488 495  HOH   HOH B . 
E 4 HOH   89  1489 175  HOH   HOH B . 
E 4 HOH   90  1490 267  HOH   HOH B . 
E 4 HOH   91  1491 288  HOH   HOH B . 
E 4 HOH   92  1492 556  HOH   HOH B . 
E 4 HOH   93  1493 121  HOH   HOH B . 
E 4 HOH   94  1494 90   HOH   HOH B . 
E 4 HOH   95  1495 248  HOH   HOH B . 
E 4 HOH   96  1496 152  HOH   HOH B . 
E 4 HOH   97  1497 27   HOH   HOH B . 
E 4 HOH   98  1498 123  HOH   HOH B . 
E 4 HOH   99  1499 423  HOH   HOH B . 
E 4 HOH   100 1500 233  HOH   HOH B . 
E 4 HOH   101 1501 366  HOH   HOH B . 
E 4 HOH   102 1502 459  HOH   HOH B . 
E 4 HOH   103 1503 261  HOH   HOH B . 
E 4 HOH   104 1504 135  HOH   HOH B . 
E 4 HOH   105 1505 262  HOH   HOH B . 
E 4 HOH   106 1506 462  HOH   HOH B . 
E 4 HOH   107 1507 173  HOH   HOH B . 
E 4 HOH   108 1508 182  HOH   HOH B . 
E 4 HOH   109 1509 12   HOH   HOH B . 
E 4 HOH   110 1510 384  HOH   HOH B . 
E 4 HOH   111 1511 98   HOH   HOH B . 
E 4 HOH   112 1512 480  HOH   HOH B . 
E 4 HOH   113 1513 201  HOH   HOH B . 
E 4 HOH   114 1514 271  HOH   HOH B . 
E 4 HOH   115 1515 518  HOH   HOH B . 
E 4 HOH   116 1516 571  HOH   HOH B . 
E 4 HOH   117 1517 89   HOH   HOH B . 
E 4 HOH   118 1518 125  HOH   HOH B . 
E 4 HOH   119 1519 166  HOH   HOH B . 
E 4 HOH   120 1520 24   HOH   HOH B . 
E 4 HOH   121 1521 438  HOH   HOH B . 
E 4 HOH   122 1522 484  HOH   HOH B . 
E 4 HOH   123 1523 235  HOH   HOH B . 
E 4 HOH   124 1524 191  HOH   HOH B . 
E 4 HOH   125 1525 68   HOH   HOH B . 
E 4 HOH   126 1526 297  HOH   HOH B . 
E 4 HOH   127 1527 305  HOH   HOH B . 
E 4 HOH   128 1528 209  HOH   HOH B . 
E 4 HOH   129 1529 249  HOH   HOH B . 
E 4 HOH   130 1530 605  HOH   HOH B . 
E 4 HOH   131 1531 138  HOH   HOH B . 
E 4 HOH   132 1532 608  HOH   HOH B . 
E 4 HOH   133 1533 210  HOH   HOH B . 
E 4 HOH   134 1534 413  HOH   HOH B . 
E 4 HOH   135 1535 144  HOH   HOH B . 
E 4 HOH   136 1536 472  HOH   HOH B . 
E 4 HOH   137 1537 373  HOH   HOH B . 
E 4 HOH   138 1538 149  HOH   HOH B . 
E 4 HOH   139 1539 498  HOH   HOH B . 
E 4 HOH   140 1540 206  HOH   HOH B . 
E 4 HOH   141 1541 385  HOH   HOH B . 
E 4 HOH   142 1542 108  HOH   HOH B . 
E 4 HOH   143 1543 48   HOH   HOH B . 
E 4 HOH   144 1544 58   HOH   HOH B . 
E 4 HOH   145 1545 266  HOH   HOH B . 
E 4 HOH   146 1546 572  HOH   HOH B . 
E 4 HOH   147 1547 319  HOH   HOH B . 
E 4 HOH   148 1548 101  HOH   HOH B . 
E 4 HOH   149 1549 410  HOH   HOH B . 
E 4 HOH   150 1550 567  HOH   HOH B . 
E 4 HOH   151 1551 40   HOH   HOH B . 
E 4 HOH   152 1552 509  HOH   HOH B . 
E 4 HOH   153 1553 524  HOH   HOH B . 
E 4 HOH   154 1554 389  HOH   HOH B . 
E 4 HOH   155 1555 560  HOH   HOH B . 
E 4 HOH   156 1556 41   HOH   HOH B . 
E 4 HOH   157 1557 94   HOH   HOH B . 
E 4 HOH   158 1558 193  HOH   HOH B . 
E 4 HOH   159 1559 601  HOH   HOH B . 
E 4 HOH   160 1560 221  HOH   HOH B . 
E 4 HOH   161 1561 521  HOH   HOH B . 
E 4 HOH   162 1562 42   HOH   HOH B . 
E 4 HOH   163 1563 330  HOH   HOH B . 
E 4 HOH   164 1564 474  HOH   HOH B . 
E 4 HOH   165 1565 510  HOH   HOH B . 
E 4 HOH   166 1566 356  HOH   HOH B . 
E 4 HOH   167 1567 255  HOH   HOH B . 
E 4 HOH   168 1568 426  HOH   HOH B . 
E 4 HOH   169 1569 532  HOH   HOH B . 
E 4 HOH   170 1570 308  HOH   HOH B . 
E 4 HOH   171 1571 343  HOH   HOH B . 
E 4 HOH   172 1572 573  HOH   HOH B . 
E 4 HOH   173 1573 511  HOH   HOH B . 
E 4 HOH   174 1574 610  HOH   HOH B . 
E 4 HOH   175 1575 420  HOH   HOH B . 
E 4 HOH   176 1576 526  HOH   HOH B . 
E 4 HOH   177 1577 322  HOH   HOH B . 
E 4 HOH   178 1578 205  HOH   HOH B . 
E 4 HOH   179 1579 301  HOH   HOH B . 
E 4 HOH   180 1580 377  HOH   HOH B . 
E 4 HOH   181 1581 351  HOH   HOH B . 
E 4 HOH   182 1582 163  HOH   HOH B . 
E 4 HOH   183 1583 586  HOH   HOH B . 
E 4 HOH   184 1584 327  HOH   HOH B . 
E 4 HOH   185 1585 155  HOH   HOH B . 
E 4 HOH   186 1586 80   HOH   HOH B . 
E 4 HOH   187 1587 208  HOH   HOH B . 
E 4 HOH   188 1588 302  HOH   HOH B . 
E 4 HOH   189 1589 180  HOH   HOH B . 
E 4 HOH   190 1590 336  HOH   HOH B . 
E 4 HOH   191 1591 107  HOH   HOH B . 
E 4 HOH   192 1592 67   HOH   HOH B . 
E 4 HOH   193 1593 231  HOH   HOH B . 
E 4 HOH   194 1594 136  HOH   HOH B . 
E 4 HOH   195 1595 538  HOH   HOH B . 
E 4 HOH   196 1596 236  HOH   HOH B . 
E 4 HOH   197 1597 171  HOH   HOH B . 
E 4 HOH   198 1598 398  HOH   HOH B . 
E 4 HOH   199 1599 574  HOH   HOH B . 
E 4 HOH   200 1600 485  HOH   HOH B . 
E 4 HOH   201 1601 396  HOH   HOH B . 
E 4 HOH   202 1602 299  HOH   HOH B . 
E 4 HOH   203 1603 315  HOH   HOH B . 
E 4 HOH   204 1604 51   HOH   HOH B . 
E 4 HOH   205 1605 357  HOH   HOH B . 
E 4 HOH   206 1606 529  HOH   HOH B . 
E 4 HOH   207 1607 593  HOH   HOH B . 
E 4 HOH   208 1608 403  HOH   HOH B . 
E 4 HOH   209 1609 457  HOH   HOH B . 
E 4 HOH   210 1610 578  HOH   HOH B . 
E 4 HOH   211 1611 596  HOH   HOH B . 
E 4 HOH   212 1612 606  HOH   HOH B . 
E 4 HOH   213 1613 321  HOH   HOH B . 
E 4 HOH   214 1614 565  HOH   HOH B . 
E 4 HOH   215 1615 551  HOH   HOH B . 
E 4 HOH   216 1616 304  HOH   HOH B . 
E 4 HOH   217 1617 178  HOH   HOH B . 
E 4 HOH   218 1618 30   HOH   HOH B . 
E 4 HOH   219 1619 223  HOH   HOH B . 
E 4 HOH   220 1620 282  HOH   HOH B . 
E 4 HOH   221 1621 450  HOH   HOH B . 
E 4 HOH   222 1622 347  HOH   HOH B . 
E 4 HOH   223 1623 211  HOH   HOH B . 
E 4 HOH   224 1624 584  HOH   HOH B . 
E 4 HOH   225 1625 473  HOH   HOH B . 
E 4 HOH   226 1626 418  HOH   HOH B . 
E 4 HOH   227 1627 563  HOH   HOH B . 
E 4 HOH   228 1628 260  HOH   HOH B . 
E 4 HOH   229 1629 611  HOH   HOH B . 
E 4 HOH   230 1630 475  HOH   HOH B . 
E 4 HOH   231 1631 587  HOH   HOH B . 
E 4 HOH   232 1632 176  HOH   HOH B . 
E 4 HOH   233 1633 326  HOH   HOH B . 
E 4 HOH   234 1634 416  HOH   HOH B . 
E 4 HOH   235 1635 506  HOH   HOH B . 
E 4 HOH   236 1636 313  HOH   HOH B . 
E 4 HOH   237 1637 451  HOH   HOH B . 
E 4 HOH   238 1638 541  HOH   HOH B . 
E 4 HOH   239 1639 435  HOH   HOH B . 
E 4 HOH   240 1640 575  HOH   HOH B . 
E 4 HOH   241 1641 160  HOH   HOH B . 
E 4 HOH   242 1642 536  HOH   HOH B . 
E 4 HOH   243 1643 116  HOH   HOH B . 
E 4 HOH   244 1644 540  HOH   HOH B . 
E 4 HOH   245 1645 291  HOH   HOH B . 
E 4 HOH   246 1646 122  HOH   HOH B . 
E 4 HOH   247 1647 501  HOH   HOH B . 
E 4 HOH   248 1648 405  HOH   HOH B . 
E 4 HOH   249 1649 372  HOH   HOH B . 
E 4 HOH   250 1650 284  HOH   HOH B . 
E 4 HOH   251 1651 440  HOH   HOH B . 
E 4 HOH   252 1652 274  HOH   HOH B . 
E 4 HOH   253 1653 598  HOH   HOH B . 
E 4 HOH   254 1654 486  HOH   HOH B . 
E 4 HOH   255 1655 285  HOH   HOH B . 
E 4 HOH   256 1656 309  HOH   HOH B . 
E 4 HOH   257 1657 482  HOH   HOH B . 
E 4 HOH   258 1658 542  HOH   HOH B . 
E 4 HOH   259 1659 448  HOH   HOH B . 
E 4 HOH   260 1660 296  HOH   HOH B . 
E 4 HOH   261 1661 402  HOH   HOH B . 
E 4 HOH   262 1662 569  HOH   HOH B . 
E 4 HOH   263 1663 535  HOH   HOH B . 
E 4 HOH   264 1664 239  HOH   HOH B . 
E 4 HOH   265 1665 188  HOH   HOH B . 
E 4 HOH   266 1666 424  HOH   HOH B . 
E 4 HOH   267 1667 553  HOH   HOH B . 
E 4 HOH   268 1668 508  HOH   HOH B . 
E 4 HOH   269 1669 590  HOH   HOH B . 
E 4 HOH   270 1670 429  HOH   HOH B . 
E 4 HOH   271 1671 434  HOH   HOH B . 
E 4 HOH   272 1672 276  HOH   HOH B . 
E 4 HOH   273 1673 502  HOH   HOH B . 
E 4 HOH   274 1674 476  HOH   HOH B . 
E 4 HOH   275 1675 550  HOH   HOH B . 
E 4 HOH   276 1676 585  HOH   HOH B . 
E 4 HOH   277 1677 503  HOH   HOH B . 
E 4 HOH   278 1678 399  HOH   HOH B . 
E 4 HOH   279 1679 428  HOH   HOH B . 
E 4 HOH   280 1680 393  HOH   HOH B . 
E 4 HOH   281 1681 580  HOH   HOH B . 
E 4 HOH   282 1682 375  HOH   HOH B . 
E 4 HOH   283 1683 576  HOH   HOH B . 
E 4 HOH   284 1684 548  HOH   HOH B . 
E 4 HOH   285 1685 374  HOH   HOH B . 
E 4 HOH   286 1686 579  HOH   HOH B . 
E 4 HOH   287 1687 353  HOH   HOH B . 
E 4 HOH   288 1688 381  HOH   HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX    ? ? ? 1.21_5207 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS       ? ? ? .         2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? pointless ? ? ? .         3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER    ? ? ? .         4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9B9T 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     79.863 
_cell.length_a_esd                 ? 
_cell.length_b                     83.714 
_cell.length_b_esd                 ? 
_cell.length_c                     130.126 
_cell.length_c_esd                 ? 
_cell.volume                       869977.046 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9B9T 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9B9T 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.91 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          57.74 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M sodium acetate trihydrate, pH 4.6, 2.0 M sodium formate' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            294 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 S 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-02-14 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.1808 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'CLSI BEAMLINE 08B1-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.1808 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   08B1-1 
_diffrn_source.pdbx_synchrotron_site       CLSI 
# 
_reflns.B_iso_Wilson_estimate                          32.12 
_reflns.entry_id                                       9B9T 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.05 
_reflns.d_resolution_low                               43.21 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     55308 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.07 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                2.0 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          14.33 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   1 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.05 
_reflns_shell.d_res_low                                     2.09 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2779 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.999 
_reflns_shell.pdbx_CC_star                                  1 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               36.04 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9B9T 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.05 
_refine.ls_d_res_low                             43.21 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     54931 
_refine.ls_number_reflns_R_free                  2650 
_refine.ls_number_reflns_R_work                  52279 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.06 
_refine.ls_percent_reflns_R_free                 4.82 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1862 
_refine.ls_R_factor_R_free                       0.1962 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1857 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.33 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 20.6490 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2105 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.05 
_refine_hist.d_res_low                        43.21 
_refine_hist.number_atoms_solvent             540 
_refine_hist.number_atoms_total               5408 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4777 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         91 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0080  ? 4900 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.1021  ? 6646 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0851  ? 744  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0219  ? 843  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 13.9797 ? 1750 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.05 2.09  . . 128 2416 88.94  . . . . 0.4289 . . . . . . . . . . . 0.4310 
'X-RAY DIFFRACTION' 2.09 2.13  . . 134 2755 99.97  . . . . 0.2472 . . . . . . . . . . . 0.2788 
'X-RAY DIFFRACTION' 2.13 2.17  . . 131 2746 100.00 . . . . 0.2303 . . . . . . . . . . . 0.2840 
'X-RAY DIFFRACTION' 2.17 2.22  . . 133 2754 99.97  . . . . 0.2282 . . . . . . . . . . . 0.2170 
'X-RAY DIFFRACTION' 2.22 2.27  . . 104 2661 95.71  . . . . 0.3011 . . . . . . . . . . . 0.3471 
'X-RAY DIFFRACTION' 2.27 2.33  . . 127 2753 100.00 . . . . 0.2156 . . . . . . . . . . . 0.2343 
'X-RAY DIFFRACTION' 2.33 2.39  . . 166 2717 100.00 . . . . 0.2112 . . . . . . . . . . . 0.2382 
'X-RAY DIFFRACTION' 2.39 2.46  . . 155 2762 99.97  . . . . 0.2124 . . . . . . . . . . . 0.2717 
'X-RAY DIFFRACTION' 2.46 2.54  . . 152 2718 100.00 . . . . 0.2173 . . . . . . . . . . . 0.2244 
'X-RAY DIFFRACTION' 2.54 2.63  . . 141 2752 100.00 . . . . 0.2057 . . . . . . . . . . . 0.2501 
'X-RAY DIFFRACTION' 2.63 2.73  . . 151 2702 98.69  . . . . 0.2152 . . . . . . . . . . . 0.2280 
'X-RAY DIFFRACTION' 2.74 2.86  . . 139 2779 99.93  . . . . 0.1931 . . . . . . . . . . . 0.2246 
'X-RAY DIFFRACTION' 2.86 3.01  . . 142 2762 100.00 . . . . 0.1975 . . . . . . . . . . . 0.1942 
'X-RAY DIFFRACTION' 3.01 3.20  . . 141 2793 100.00 . . . . 0.1892 . . . . . . . . . . . 0.2081 
'X-RAY DIFFRACTION' 3.20 3.45  . . 119 2789 99.69  . . . . 0.1706 . . . . . . . . . . . 0.1655 
'X-RAY DIFFRACTION' 3.45 3.79  . . 131 2817 99.86  . . . . 0.1558 . . . . . . . . . . . 0.1506 
'X-RAY DIFFRACTION' 3.79 4.34  . . 142 2800 99.66  . . . . 0.1463 . . . . . . . . . . . 0.1445 
'X-RAY DIFFRACTION' 4.34 5.47  . . 158 2842 99.97  . . . . 0.1388 . . . . . . . . . . . 0.1418 
'X-RAY DIFFRACTION' 5.47 43.21 . . 156 2963 99.62  . . . . 0.1797 . . . . . . . . . . . 0.1854 
# 
_struct.entry_id                     9B9T 
_struct.title                        'Crystal structure of the ternary complex of DCAF1 and WDR5 with PROTAC, OICR-40407' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9B9T 
_struct_keywords.text            'E3 ligase, adaptor, PROTAC, WDR, ternary complex, PROTEIN BINDING' 
_struct_keywords.pdbx_keywords   'PROTEIN BINDING' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP WDR5_HUMAN  P61964 ? 1 
;TQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV
SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDG
SLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIF
ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
;
24   
2 UNP DCAF1_HUMAN Q9Y4B6 ? 2 
;FRPISVFREANEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSATWSQP
LSALWGMKSVFDMKHSFTEDHYVEFSKHSQDRVIGTKGDIAHIYDIQTGNKLLTLFNPDLANNYKRNCATFNPTDDLVLN
DGVLWDVRSAQAIHKFDKFNMNISGVFHPNGLEVIINTEIWDLRTFHLLHTVPALDQCRVVFNHTGTVMYGAMLQADDED
DLMEERMKSPFGSSFRTFNATDYKPIATIDVKRNIFDLCTDTKDCYLAVIENQGSMDALNMDTVCRLYEVG
;
1080 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9B9T A 19 ? 329 ? P61964 24   ? 334  ? 24   334  
2 2 9B9T B 28 ? 338 ? Q9Y4B6 1080 ? 1390 ? 1080 1390 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9B9T MET A 1  ? UNP P61964 ? ? 'initiating methionine' 6    1  
1 9B9T HIS A 2  ? UNP P61964 ? ? 'expression tag'        7    2  
1 9B9T HIS A 3  ? UNP P61964 ? ? 'expression tag'        8    3  
1 9B9T HIS A 4  ? UNP P61964 ? ? 'expression tag'        9    4  
1 9B9T HIS A 5  ? UNP P61964 ? ? 'expression tag'        10   5  
1 9B9T HIS A 6  ? UNP P61964 ? ? 'expression tag'        11   6  
1 9B9T HIS A 7  ? UNP P61964 ? ? 'expression tag'        12   7  
1 9B9T SER A 8  ? UNP P61964 ? ? 'expression tag'        13   8  
1 9B9T SER A 9  ? UNP P61964 ? ? 'expression tag'        14   9  
1 9B9T GLY A 10 ? UNP P61964 ? ? 'expression tag'        15   10 
1 9B9T ARG A 11 ? UNP P61964 ? ? 'expression tag'        16   11 
1 9B9T GLU A 12 ? UNP P61964 ? ? 'expression tag'        17   12 
1 9B9T ASN A 13 ? UNP P61964 ? ? 'expression tag'        18   13 
1 9B9T LEU A 14 ? UNP P61964 ? ? 'expression tag'        19   14 
1 9B9T TYR A 15 ? UNP P61964 ? ? 'expression tag'        20   15 
1 9B9T PHE A 16 ? UNP P61964 ? ? 'expression tag'        21   16 
1 9B9T GLN A 17 ? UNP P61964 ? ? 'expression tag'        22   17 
1 9B9T GLY A 18 ? UNP P61964 ? ? 'expression tag'        23   18 
2 9B9T MET B 1  ? UNP Q9Y4B6 ? ? 'initiating methionine' 1053 19 
2 9B9T GLY B 2  ? UNP Q9Y4B6 ? ? 'expression tag'        1054 20 
2 9B9T SER B 3  ? UNP Q9Y4B6 ? ? 'expression tag'        1055 21 
2 9B9T SER B 4  ? UNP Q9Y4B6 ? ? 'expression tag'        1056 22 
2 9B9T HIS B 5  ? UNP Q9Y4B6 ? ? 'expression tag'        1057 23 
2 9B9T HIS B 6  ? UNP Q9Y4B6 ? ? 'expression tag'        1058 24 
2 9B9T HIS B 7  ? UNP Q9Y4B6 ? ? 'expression tag'        1059 25 
2 9B9T HIS B 8  ? UNP Q9Y4B6 ? ? 'expression tag'        1060 26 
2 9B9T HIS B 9  ? UNP Q9Y4B6 ? ? 'expression tag'        1061 27 
2 9B9T HIS B 10 ? UNP Q9Y4B6 ? ? 'expression tag'        1062 28 
2 9B9T SER B 11 ? UNP Q9Y4B6 ? ? 'expression tag'        1063 29 
2 9B9T SER B 12 ? UNP Q9Y4B6 ? ? 'expression tag'        1064 30 
2 9B9T GLY B 13 ? UNP Q9Y4B6 ? ? 'expression tag'        1065 31 
2 9B9T ARG B 14 ? UNP Q9Y4B6 ? ? 'expression tag'        1066 32 
2 9B9T GLU B 15 ? UNP Q9Y4B6 ? ? 'expression tag'        1067 33 
2 9B9T ASN B 16 ? UNP Q9Y4B6 ? ? 'expression tag'        1068 34 
2 9B9T LEU B 17 ? UNP Q9Y4B6 ? ? 'expression tag'        1069 35 
2 9B9T TYR B 18 ? UNP Q9Y4B6 ? ? 'expression tag'        1070 36 
2 9B9T PHE B 19 ? UNP Q9Y4B6 ? ? 'expression tag'        1071 37 
2 9B9T GLN B 20 ? UNP Q9Y4B6 ? ? 'expression tag'        1072 38 
2 9B9T GLY B 21 ? UNP Q9Y4B6 ? ? 'expression tag'        1073 39 
2 9B9T SER B 22 ? UNP Q9Y4B6 ? ? 'expression tag'        1074 40 
2 9B9T SER B 23 ? UNP Q9Y4B6 ? ? 'expression tag'        1075 41 
2 9B9T ARG B 24 ? UNP Q9Y4B6 ? ? 'expression tag'        1076 42 
2 9B9T ALA B 25 ? UNP Q9Y4B6 ? ? 'expression tag'        1077 43 
2 9B9T SER B 26 ? UNP Q9Y4B6 ? ? 'expression tag'        1078 44 
2 9B9T ALA B 27 ? UNP Q9Y4B6 ? ? 'expression tag'        1079 45 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
_struct_conf.conf_type_id            HELX_P 
_struct_conf.id                      HELX_P1 
_struct_conf.pdbx_PDB_helix_id       AA1 
_struct_conf.beg_label_comp_id       PRO 
_struct_conf.beg_label_asym_id       B 
_struct_conf.beg_label_seq_id        240 
_struct_conf.pdbx_beg_PDB_ins_code   ? 
_struct_conf.end_label_comp_id       ASP 
_struct_conf.end_label_asym_id       B 
_struct_conf.end_label_seq_id        243 
_struct_conf.pdbx_end_PDB_ins_code   ? 
_struct_conf.beg_auth_comp_id        PRO 
_struct_conf.beg_auth_asym_id        B 
_struct_conf.beg_auth_seq_id         1292 
_struct_conf.end_auth_comp_id        ASP 
_struct_conf.end_auth_asym_id        B 
_struct_conf.end_auth_seq_id         1295 
_struct_conf.pdbx_PDB_helix_class    5 
_struct_conf.details                 ? 
_struct_conf.pdbx_PDB_helix_length   4 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          GLN 
_struct_mon_prot_cis.label_seq_id           106 
_struct_mon_prot_cis.label_asym_id          B 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           GLN 
_struct_mon_prot_cis.auth_seq_id            1158 
_struct_mon_prot_cis.auth_asym_id           B 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    107 
_struct_mon_prot_cis.pdbx_label_asym_id_2   B 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     1159 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    B 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       0.24 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 4 ? 
AA3 ? 4 ? 
AA4 ? 4 ? 
AA5 ? 4 ? 
AA6 ? 4 ? 
AA7 ? 4 ? 
AA8 ? 4 ? 
AA9 ? 4 ? 
AB1 ? 4 ? 
AB2 ? 4 ? 
AB3 ? 4 ? 
AB4 ? 4 ? 
AB5 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
AA8 3 4 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AA9 2 3 ? anti-parallel 
AA9 3 4 ? anti-parallel 
AB1 1 2 ? anti-parallel 
AB1 2 3 ? anti-parallel 
AB1 3 4 ? anti-parallel 
AB2 1 2 ? anti-parallel 
AB2 2 3 ? anti-parallel 
AB2 3 4 ? anti-parallel 
AB3 1 2 ? anti-parallel 
AB3 2 3 ? anti-parallel 
AB3 3 4 ? anti-parallel 
AB4 1 2 ? anti-parallel 
AB4 2 3 ? anti-parallel 
AB4 3 4 ? anti-parallel 
AB5 1 2 ? anti-parallel 
AB5 2 3 ? anti-parallel 
AB5 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 31  ? LEU A 36  ? ALA A 36   LEU A 41   
AA1 2 ILE A 322 ? LYS A 326 ? ILE A 327  LYS A 331  
AA1 3 ILE A 310 ? ALA A 315 ? ILE A 315  ALA A 320  
AA1 4 VAL A 299 ? CYS A 304 ? VAL A 304  CYS A 309  
AA2 1 VAL A 43  ? PHE A 48  ? VAL A 48   PHE A 53   
AA2 2 TRP A 54  ? SER A 59  ? TRP A 59   SER A 64   
AA2 3 ILE A 64  ? GLY A 68  ? ILE A 69   GLY A 73   
AA2 4 PHE A 74  ? ILE A 78  ? PHE A 79   ILE A 83   
AA3 1 ILE A 85  ? TRP A 90  ? ILE A 90   TRP A 95   
AA3 2 LEU A 96  ? SER A 101 ? LEU A 101  SER A 106  
AA3 3 LEU A 106 ? ASP A 110 ? LEU A 111  ASP A 115  
AA3 4 LYS A 115 ? LEU A 120 ? LYS A 120  LEU A 125  
AA4 1 VAL A 127 ? PHE A 132 ? VAL A 132  PHE A 137  
AA4 2 LEU A 138 ? SER A 143 ? LEU A 143  SER A 148  
AA4 3 VAL A 148 ? ASP A 152 ? VAL A 153  ASP A 157  
AA4 4 CYS A 158 ? LEU A 162 ? CYS A 163  LEU A 167  
AA5 1 VAL A 169 ? PHE A 174 ? VAL A 174  PHE A 179  
AA5 2 LEU A 180 ? SER A 185 ? LEU A 185  SER A 190  
AA5 3 CYS A 190 ? ASP A 194 ? CYS A 195  ASP A 199  
AA5 4 CYS A 200 ? LEU A 204 ? CYS A 205  LEU A 209  
AA6 1 VAL A 212 ? PHE A 217 ? VAL A 217  PHE A 222  
AA6 2 ILE A 224 ? THR A 228 ? ILE A 229  THR A 233  
AA6 3 THR A 232 ? ASP A 237 ? THR A 237  ASP A 242  
AA6 4 LYS A 242 ? TYR A 247 ? LYS A 247  TYR A 252  
AA7 1 ALA A 259 ? SER A 262 ? ALA A 264  SER A 267  
AA7 2 TRP A 268 ? SER A 271 ? TRP A 273  SER A 276  
AA7 3 VAL A 278 ? ASN A 282 ? VAL A 283  ASN A 287  
AA7 4 ILE A 288 ? LEU A 292 ? ILE A 293  LEU A 297  
AA8 1 PHE B 28  ? ARG B 35  ? PHE B 1080 ARG B 1087 
AA8 2 THR B 330 ? VAL B 337 ? THR B 1382 VAL B 1389 
AA8 3 TYR B 313 ? ASN B 319 ? TYR B 1365 ASN B 1371 
AA8 4 ILE B 302 ? THR B 307 ? ILE B 1354 THR B 1359 
AA9 1 PHE B 44  ? PHE B 49  ? PHE B 1096 PHE B 1101 
AA9 2 PHE B 55  ? THR B 60  ? PHE B 1107 THR B 1112 
AA9 3 GLN B 64  ? ASN B 69  ? GLN B 1116 ASN B 1121 
AA9 4 GLU B 75  ? ASN B 80  ? GLU B 1127 ASN B 1132 
AB1 1 HIS B 88  ? PRO B 91  ? HIS B 1140 PRO B 1143 
AB1 2 LEU B 97  ? SER B 101 ? LEU B 1149 SER B 1153 
AB1 3 SER B 109 ? GLY B 113 ? SER B 1161 GLY B 1165 
AB1 4 ASP B 119 ? PHE B 124 ? ASP B 1171 PHE B 1176 
AB2 1 TYR B 129 ? PHE B 132 ? TYR B 1181 PHE B 1184 
AB2 2 ARG B 139 ? LYS B 144 ? ARG B 1191 LYS B 1196 
AB2 3 ILE B 147 ? ASP B 152 ? ILE B 1199 ASP B 1204 
AB2 4 LYS B 158 ? LEU B 162 ? LYS B 1210 LEU B 1214 
AB3 1 THR B 177 ? PHE B 178 ? THR B 1229 PHE B 1230 
AB3 2 LEU B 184 ? ASN B 187 ? LEU B 1236 ASN B 1239 
AB3 3 VAL B 190 ? ASP B 193 ? VAL B 1242 ASP B 1245 
AB3 4 GLN B 198 ? LYS B 202 ? GLN B 1250 LYS B 1254 
AB4 1 VAL B 213 ? PHE B 214 ? VAL B 1265 PHE B 1266 
AB4 2 GLU B 220 ? ILE B 223 ? GLU B 1272 ILE B 1275 
AB4 3 GLU B 226 ? ASP B 229 ? GLU B 1278 ASP B 1281 
AB4 4 LEU B 235 ? THR B 238 ? LEU B 1287 THR B 1290 
AB5 1 CYS B 245 ? PHE B 249 ? CYS B 1297 PHE B 1301 
AB5 2 VAL B 255 ? LEU B 261 ? VAL B 1307 LEU B 1313 
AB5 3 PHE B 278 ? ASN B 286 ? PHE B 1330 ASN B 1338 
AB5 4 PRO B 292 ? ASP B 297 ? PRO B 1344 ASP B 1349 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N LEU A 36  ? N LEU A 41   O ILE A 322 ? O ILE A 327  
AA1 2 3 O LYS A 323 ? O LYS A 328  N SER A 313 ? N SER A 318  
AA1 3 4 O ALA A 314 ? O ALA A 319  N SER A 301 ? N SER A 306  
AA2 1 2 N LYS A 47  ? N LYS A 52   O ALA A 56  ? O ALA A 61   
AA2 2 3 N LEU A 55  ? N LEU A 60   O TRP A 67  ? O TRP A 72   
AA2 3 4 N ILE A 64  ? N ILE A 69   O ILE A 78  ? O ILE A 83   
AA3 1 2 N ASP A 87  ? N ASP A 92   O ALA A 100 ? O ALA A 105  
AA3 2 3 N LEU A 97  ? N LEU A 102  O TRP A 109 ? O TRP A 114  
AA3 3 4 N LEU A 106 ? N LEU A 111  O LEU A 120 ? O LEU A 125  
AA4 1 2 N ASN A 131 ? N ASN A 136  O VAL A 140 ? O VAL A 145  
AA4 2 3 N ILE A 139 ? N ILE A 144  O TRP A 151 ? O TRP A 156  
AA4 3 4 N VAL A 148 ? N VAL A 153  O LEU A 162 ? O LEU A 167  
AA5 1 2 N HIS A 173 ? N HIS A 178  O VAL A 182 ? O VAL A 187  
AA5 2 3 N ILE A 181 ? N ILE A 186  O TRP A 193 ? O TRP A 198  
AA5 3 4 N ILE A 192 ? N ILE A 197  O LEU A 201 ? O LEU A 206  
AA6 1 2 N LYS A 216 ? N LYS A 221  O LEU A 225 ? O LEU A 230  
AA6 2 3 N ILE A 224 ? N ILE A 229  O TRP A 236 ? O TRP A 241  
AA6 3 4 N ASP A 237 ? N ASP A 242  O LYS A 242 ? O LYS A 247  
AA7 1 2 N SER A 262 ? N SER A 267  O TRP A 268 ? O TRP A 273  
AA7 2 3 N SER A 271 ? N SER A 276  O TYR A 279 ? O TYR A 284  
AA7 3 4 N VAL A 278 ? N VAL A 283  O LEU A 292 ? O LEU A 297  
AA8 1 2 N PHE B 34  ? N PHE B 1086 O CYS B 332 ? O CYS B 1384 
AA8 2 3 O VAL B 331 ? O VAL B 1383 N GLU B 318 ? N GLU B 1370 
AA8 3 4 O ILE B 317 ? O ILE B 1369 N PHE B 303 ? N PHE B 1355 
AA9 1 2 N ALA B 48  ? N ALA B 1100 O MET B 57  ? O MET B 1109 
AA9 2 3 N LEU B 58  ? N LEU B 1110 O LYS B 66  ? O LYS B 1118 
AA9 3 4 N LEU B 67  ? N LEU B 1119 O GLU B 76  ? O GLU B 1128 
AB1 1 2 N GLU B 90  ? N GLU B 1142 O LEU B 99  ? O LEU B 1151 
AB1 2 3 N LEU B 98  ? N LEU B 1150 O TRP B 112 ? O TRP B 1164 
AB1 3 4 N GLY B 113 ? N GLY B 1165 O ASP B 119 ? O ASP B 1171 
AB2 1 2 N GLU B 131 ? N GLU B 1183 O ILE B 141 ? O ILE B 1193 
AB2 2 3 N GLY B 142 ? N GLY B 1194 O HIS B 149 ? O HIS B 1201 
AB2 3 4 N ILE B 150 ? N ILE B 1202 O LEU B 159 ? O LEU B 1211 
AB3 1 2 N THR B 177 ? N THR B 1229 O LEU B 186 ? O LEU B 1238 
AB3 2 3 N VAL B 185 ? N VAL B 1237 O TRP B 192 ? O TRP B 1244 
AB3 3 4 N ASP B 193 ? N ASP B 1245 O GLN B 198 ? O GLN B 1250 
AB4 1 2 N VAL B 213 ? N VAL B 1265 O ILE B 222 ? O ILE B 1274 
AB4 2 3 N ILE B 223 ? N ILE B 1275 O GLU B 226 ? O GLU B 1278 
AB4 3 4 N ILE B 227 ? N ILE B 1279 O LEU B 236 ? O LEU B 1288 
AB5 1 2 N VAL B 248 ? N VAL B 1300 O TYR B 257 ? O TYR B 1309 
AB5 2 3 N GLY B 258 ? N GLY B 1310 O ARG B 283 ? O ARG B 1335 
AB5 3 4 N PHE B 282 ? N PHE B 1334 O ILE B 296 ? O ILE B 1348 
# 
_pdbx_entry_details.entry_id                   9B9T 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 O A HOH 1553 ? ? O A HOH 1733 ? ? 1.95 
2  1 O B HOH 1573 ? ? O B HOH 1655 ? ? 2.02 
3  1 O A HOH 1719 ? ? O A HOH 1723 ? ? 2.03 
4  1 O B HOH 1509 ? ? O B HOH 1649 ? ? 2.04 
5  1 O B GLU 1324 ? ? O B HOH 1401 ? ? 2.05 
6  1 O B HOH 1423 ? ? O B HOH 1529 ? ? 2.07 
7  1 O B HOH 1559 ? ? O B HOH 1612 ? ? 2.12 
8  1 O B HOH 1565 ? ? O B HOH 1648 ? ? 2.13 
9  1 O A HOH 1595 ? ? O A HOH 1661 ? ? 2.13 
10 1 O A HOH 1714 ? ? O A HOH 1722 ? ? 2.15 
11 1 O B HOH 1424 ? ? O B HOH 1437 ? ? 2.17 
12 1 O A HOH 1656 ? ? O A HOH 1710 ? ? 2.18 
13 1 O B HOH 1558 ? ? O B HOH 1638 ? ? 2.18 
14 1 O B HOH 1519 ? ? O B HOH 1586 ? ? 2.19 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 CB B GLU 1105 ? ? CA B GLU 1105 ? ? C  B GLU 1105 ? ? 95.75  110.40 -14.65 2.00 N 
2 1 N  B GLU 1105 ? ? CA B GLU 1105 ? ? C  B GLU 1105 ? ? 153.10 111.00 42.10  2.70 N 
3 1 N  B ARG 1106 ? ? CA B ARG 1106 ? ? CB B ARG 1106 ? ? 94.91  110.60 -15.69 1.80 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 LYS A 109  ? ? 80.82   6.41    
2  1 GLU A 151  ? ? 81.56   4.10    
3  1 ASP A 192  ? ? -69.84  2.73    
4  1 ASP A 211  ? ? -109.20 -135.48 
5  1 LEU A 234  ? ? -76.00  35.42   
6  1 ASN A 257  ? ? -158.90 88.81   
7  1 LYS A 259  ? ? -131.45 -43.72  
8  1 ASP A 324  ? ? -130.96 -59.48  
9  1 GLU B 1105 ? ? -32.80  -30.05  
10 1 ALA B 1154 ? ? -107.27 -155.33 
11 1 SER B 1168 ? ? 48.65   -121.11 
12 1 ASN B 1276 ? ? 62.51   -126.77 
13 1 ALA B 1315 ? ? 88.74   134.86  
14 1 MET B 1322 ? ? -49.60  -0.37   
15 1 ASP B 1381 ? ? -161.29 85.54   
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG A 181  ? ? 0.192 'SIDE CHAIN' 
2 1 ARG B 1104 ? ? 0.118 'SIDE CHAIN' 
3 1 ARG B 1283 ? ? 0.278 'SIDE CHAIN' 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1751 ? 6.01  . 
2 1 O ? A HOH 1752 ? 9.43  . 
3 1 O ? B HOH 1685 ? 5.85  . 
4 1 O ? B HOH 1686 ? 6.97  . 
5 1 O ? B HOH 1687 ? 12.26 . 
6 1 O ? B HOH 1688 ? 14.10 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 6    ? A MET 1   
2  1 Y 1 A HIS 7    ? A HIS 2   
3  1 Y 1 A HIS 8    ? A HIS 3   
4  1 Y 1 A HIS 9    ? A HIS 4   
5  1 Y 1 A HIS 10   ? A HIS 5   
6  1 Y 1 A HIS 11   ? A HIS 6   
7  1 Y 1 A HIS 12   ? A HIS 7   
8  1 Y 1 A SER 13   ? A SER 8   
9  1 Y 1 A SER 14   ? A SER 9   
10 1 Y 1 A GLY 15   ? A GLY 10  
11 1 Y 1 A ARG 16   ? A ARG 11  
12 1 Y 1 A GLU 17   ? A GLU 12  
13 1 Y 1 A ASN 18   ? A ASN 13  
14 1 Y 1 A LEU 19   ? A LEU 14  
15 1 Y 1 A TYR 20   ? A TYR 15  
16 1 Y 1 A PHE 21   ? A PHE 16  
17 1 Y 1 A GLN 22   ? A GLN 17  
18 1 Y 1 A GLY 23   ? A GLY 18  
19 1 Y 1 A THR 24   ? A THR 19  
20 1 Y 1 A GLN 25   ? A GLN 20  
21 1 Y 1 A SER 26   ? A SER 21  
22 1 Y 1 A LYS 27   ? A LYS 22  
23 1 Y 1 A PRO 28   ? A PRO 23  
24 1 Y 1 A THR 29   ? A THR 24  
25 1 Y 1 B MET 1053 ? B MET 1   
26 1 Y 1 B GLY 1054 ? B GLY 2   
27 1 Y 1 B SER 1055 ? B SER 3   
28 1 Y 1 B SER 1056 ? B SER 4   
29 1 Y 1 B HIS 1057 ? B HIS 5   
30 1 Y 1 B HIS 1058 ? B HIS 6   
31 1 Y 1 B HIS 1059 ? B HIS 7   
32 1 Y 1 B HIS 1060 ? B HIS 8   
33 1 Y 1 B HIS 1061 ? B HIS 9   
34 1 Y 1 B HIS 1062 ? B HIS 10  
35 1 Y 1 B SER 1063 ? B SER 11  
36 1 Y 1 B SER 1064 ? B SER 12  
37 1 Y 1 B GLY 1065 ? B GLY 13  
38 1 Y 1 B ARG 1066 ? B ARG 14  
39 1 Y 1 B GLU 1067 ? B GLU 15  
40 1 Y 1 B ASN 1068 ? B ASN 16  
41 1 Y 1 B LEU 1069 ? B LEU 17  
42 1 Y 1 B TYR 1070 ? B TYR 18  
43 1 Y 1 B PHE 1071 ? B PHE 19  
44 1 Y 1 B GLN 1072 ? B GLN 20  
45 1 Y 1 B GLY 1073 ? B GLY 21  
46 1 Y 1 B SER 1074 ? B SER 22  
47 1 Y 1 B SER 1075 ? B SER 23  
48 1 Y 1 B ARG 1076 ? B ARG 24  
49 1 Y 1 B ALA 1077 ? B ALA 25  
50 1 Y 1 B SER 1078 ? B SER 26  
51 1 Y 1 B ASP 1317 ? B ASP 265 
52 1 Y 1 B GLU 1318 ? B GLU 266 
53 1 Y 1 B ASP 1319 ? B ASP 267 
54 1 Y 1 B ASP 1320 ? B ASP 268 
55 1 Y 1 B SER 1374 ? B SER 322 
56 1 Y 1 B MET 1375 ? B MET 323 
57 1 Y 1 B ASP 1376 ? B ASP 324 
58 1 Y 1 B ALA 1377 ? B ALA 325 
59 1 Y 1 B LEU 1378 ? B LEU 326 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1ANM C01  C  N N 1   
A1ANM C03  C  N S 2   
A1ANM C04  C  N N 3   
A1ANM C06  C  Y N 4   
A1ANM C07  C  Y N 5   
A1ANM C08  C  Y N 6   
A1ANM C09  C  Y N 7   
A1ANM C10  C  Y N 8   
A1ANM C11  C  Y N 9   
A1ANM C13  C  Y N 10  
A1ANM C14  C  Y N 11  
A1ANM C15  C  Y N 12  
A1ANM C16  C  N N 13  
A1ANM C19  C  N N 14  
A1ANM C20  C  N N 15  
A1ANM C22  C  N N 16  
A1ANM C23  C  N N 17  
A1ANM C25  C  N N 18  
A1ANM C26  C  N N 19  
A1ANM C28  C  N N 20  
A1ANM C29  C  N N 21  
A1ANM C31  C  N N 22  
A1ANM C32  C  N N 23  
A1ANM C34  C  N N 24  
A1ANM C36  C  N N 25  
A1ANM C38  C  Y N 26  
A1ANM C39  C  Y N 27  
A1ANM C40  C  Y N 28  
A1ANM C42  C  Y N 29  
A1ANM C43  C  Y N 30  
A1ANM C44  C  N N 31  
A1ANM C47  C  N S 32  
A1ANM C48  C  N N 33  
A1ANM C49  C  N N 34  
A1ANM C52  C  Y N 35  
A1ANM C53  C  Y N 36  
A1ANM C54  C  Y N 37  
A1ANM C56  C  Y N 38  
A1ANM C58  C  Y N 39  
A1ANM C59  C  Y N 40  
A1ANM C60  C  Y N 41  
A1ANM C61  C  Y N 42  
A1ANM C62  C  Y N 43  
A1ANM C63  C  Y N 44  
A1ANM C64  C  Y N 45  
A1ANM C66  C  Y N 46  
A1ANM C67  C  Y N 47  
A1ANM C69  C  Y N 48  
A1ANM C71  C  Y N 49  
A1ANM C72  C  Y N 50  
A1ANM C73  C  Y N 51  
A1ANM C75  C  N N 52  
A1ANM C77  C  N N 53  
A1ANM C78  C  N N 54  
A1ANM C79  C  N N 55  
A1ANM C83  C  N N 56  
A1ANM C84  C  N N 57  
A1ANM C87  C  N N 58  
A1ANM C88  C  N N 59  
A1ANM C89  C  N R 60  
A1ANM C90  C  N N 61  
A1ANM C91  C  N N 62  
A1ANM F12  F  N N 63  
A1ANM F57  F  N N 64  
A1ANM F68  F  N N 65  
A1ANM F80  F  N N 66  
A1ANM F81  F  N N 67  
A1ANM F82  F  N N 68  
A1ANM N02  N  N N 69  
A1ANM N05  N  N N 70  
A1ANM N18  N  N N 71  
A1ANM N33  N  N N 72  
A1ANM N37  N  Y N 73  
A1ANM N41  N  Y N 74  
A1ANM N46  N  N N 75  
A1ANM N51  N  N N 76  
A1ANM N70  N  Y N 77  
A1ANM N74  N  N N 78  
A1ANM N86  N  N N 79  
A1ANM O17  O  N N 80  
A1ANM O21  O  N N 81  
A1ANM O24  O  N N 82  
A1ANM O27  O  N N 83  
A1ANM O30  O  N N 84  
A1ANM O35  O  N N 85  
A1ANM O45  O  N N 86  
A1ANM O50  O  N N 87  
A1ANM O76  O  N N 88  
A1ANM O85  O  N N 89  
A1ANM CL55 CL N N 90  
A1ANM CL65 CL N N 91  
A1ANM H012 H  N N 92  
A1ANM H011 H  N N 93  
A1ANM H013 H  N N 94  
A1ANM H031 H  N N 95  
A1ANM H042 H  N N 96  
A1ANM H041 H  N N 97  
A1ANM H071 H  N N 98  
A1ANM H081 H  N N 99  
A1ANM H131 H  N N 100 
A1ANM H141 H  N N 101 
A1ANM H191 H  N N 102 
A1ANM H192 H  N N 103 
A1ANM H202 H  N N 104 
A1ANM H201 H  N N 105 
A1ANM H222 H  N N 106 
A1ANM H221 H  N N 107 
A1ANM H231 H  N N 108 
A1ANM H232 H  N N 109 
A1ANM H251 H  N N 110 
A1ANM H252 H  N N 111 
A1ANM H262 H  N N 112 
A1ANM H261 H  N N 113 
A1ANM H282 H  N N 114 
A1ANM H281 H  N N 115 
A1ANM H292 H  N N 116 
A1ANM H291 H  N N 117 
A1ANM H311 H  N N 118 
A1ANM H312 H  N N 119 
A1ANM H322 H  N N 120 
A1ANM H321 H  N N 121 
A1ANM H361 H  N N 122 
A1ANM H362 H  N N 123 
A1ANM H381 H  N N 124 
A1ANM H421 H  N N 125 
A1ANM H471 H  N N 126 
A1ANM H481 H  N N 127 
A1ANM H482 H  N N 128 
A1ANM H531 H  N N 129 
A1ANM H581 H  N N 130 
A1ANM H591 H  N N 131 
A1ANM H621 H  N N 132 
A1ANM H631 H  N N 133 
A1ANM H661 H  N N 134 
A1ANM H691 H  N N 135 
A1ANM H711 H  N N 136 
A1ANM H721 H  N N 137 
A1ANM H831 H  N N 138 
A1ANM H871 H  N N 139 
A1ANM H881 H  N N 140 
A1ANM H882 H  N N 141 
A1ANM H891 H  N N 142 
A1ANM H901 H  N N 143 
A1ANM H903 H  N N 144 
A1ANM H902 H  N N 145 
A1ANM H911 H  N N 146 
A1ANM H912 H  N N 147 
A1ANM H913 H  N N 148 
A1ANM H181 H  N N 149 
A1ANM H331 H  N N 150 
A1ANM H411 H  N N 151 
A1ANM H461 H  N N 152 
A1ANM H511 H  N N 153 
A1ANM H512 H  N N 154 
A1ANM H741 H  N N 155 
A1ANM H861 H  N N 156 
ALA   N    N  N N 157 
ALA   CA   C  N S 158 
ALA   C    C  N N 159 
ALA   O    O  N N 160 
ALA   CB   C  N N 161 
ALA   OXT  O  N N 162 
ALA   H    H  N N 163 
ALA   H2   H  N N 164 
ALA   HA   H  N N 165 
ALA   HB1  H  N N 166 
ALA   HB2  H  N N 167 
ALA   HB3  H  N N 168 
ALA   HXT  H  N N 169 
ARG   N    N  N N 170 
ARG   CA   C  N S 171 
ARG   C    C  N N 172 
ARG   O    O  N N 173 
ARG   CB   C  N N 174 
ARG   CG   C  N N 175 
ARG   CD   C  N N 176 
ARG   NE   N  N N 177 
ARG   CZ   C  N N 178 
ARG   NH1  N  N N 179 
ARG   NH2  N  N N 180 
ARG   OXT  O  N N 181 
ARG   H    H  N N 182 
ARG   H2   H  N N 183 
ARG   HA   H  N N 184 
ARG   HB2  H  N N 185 
ARG   HB3  H  N N 186 
ARG   HG2  H  N N 187 
ARG   HG3  H  N N 188 
ARG   HD2  H  N N 189 
ARG   HD3  H  N N 190 
ARG   HE   H  N N 191 
ARG   HH11 H  N N 192 
ARG   HH12 H  N N 193 
ARG   HH21 H  N N 194 
ARG   HH22 H  N N 195 
ARG   HXT  H  N N 196 
ASN   N    N  N N 197 
ASN   CA   C  N S 198 
ASN   C    C  N N 199 
ASN   O    O  N N 200 
ASN   CB   C  N N 201 
ASN   CG   C  N N 202 
ASN   OD1  O  N N 203 
ASN   ND2  N  N N 204 
ASN   OXT  O  N N 205 
ASN   H    H  N N 206 
ASN   H2   H  N N 207 
ASN   HA   H  N N 208 
ASN   HB2  H  N N 209 
ASN   HB3  H  N N 210 
ASN   HD21 H  N N 211 
ASN   HD22 H  N N 212 
ASN   HXT  H  N N 213 
ASP   N    N  N N 214 
ASP   CA   C  N S 215 
ASP   C    C  N N 216 
ASP   O    O  N N 217 
ASP   CB   C  N N 218 
ASP   CG   C  N N 219 
ASP   OD1  O  N N 220 
ASP   OD2  O  N N 221 
ASP   OXT  O  N N 222 
ASP   H    H  N N 223 
ASP   H2   H  N N 224 
ASP   HA   H  N N 225 
ASP   HB2  H  N N 226 
ASP   HB3  H  N N 227 
ASP   HD2  H  N N 228 
ASP   HXT  H  N N 229 
CYS   N    N  N N 230 
CYS   CA   C  N R 231 
CYS   C    C  N N 232 
CYS   O    O  N N 233 
CYS   CB   C  N N 234 
CYS   SG   S  N N 235 
CYS   OXT  O  N N 236 
CYS   H    H  N N 237 
CYS   H2   H  N N 238 
CYS   HA   H  N N 239 
CYS   HB2  H  N N 240 
CYS   HB3  H  N N 241 
CYS   HG   H  N N 242 
CYS   HXT  H  N N 243 
GLN   N    N  N N 244 
GLN   CA   C  N S 245 
GLN   C    C  N N 246 
GLN   O    O  N N 247 
GLN   CB   C  N N 248 
GLN   CG   C  N N 249 
GLN   CD   C  N N 250 
GLN   OE1  O  N N 251 
GLN   NE2  N  N N 252 
GLN   OXT  O  N N 253 
GLN   H    H  N N 254 
GLN   H2   H  N N 255 
GLN   HA   H  N N 256 
GLN   HB2  H  N N 257 
GLN   HB3  H  N N 258 
GLN   HG2  H  N N 259 
GLN   HG3  H  N N 260 
GLN   HE21 H  N N 261 
GLN   HE22 H  N N 262 
GLN   HXT  H  N N 263 
GLU   N    N  N N 264 
GLU   CA   C  N S 265 
GLU   C    C  N N 266 
GLU   O    O  N N 267 
GLU   CB   C  N N 268 
GLU   CG   C  N N 269 
GLU   CD   C  N N 270 
GLU   OE1  O  N N 271 
GLU   OE2  O  N N 272 
GLU   OXT  O  N N 273 
GLU   H    H  N N 274 
GLU   H2   H  N N 275 
GLU   HA   H  N N 276 
GLU   HB2  H  N N 277 
GLU   HB3  H  N N 278 
GLU   HG2  H  N N 279 
GLU   HG3  H  N N 280 
GLU   HE2  H  N N 281 
GLU   HXT  H  N N 282 
GLY   N    N  N N 283 
GLY   CA   C  N N 284 
GLY   C    C  N N 285 
GLY   O    O  N N 286 
GLY   OXT  O  N N 287 
GLY   H    H  N N 288 
GLY   H2   H  N N 289 
GLY   HA2  H  N N 290 
GLY   HA3  H  N N 291 
GLY   HXT  H  N N 292 
HIS   N    N  N N 293 
HIS   CA   C  N S 294 
HIS   C    C  N N 295 
HIS   O    O  N N 296 
HIS   CB   C  N N 297 
HIS   CG   C  Y N 298 
HIS   ND1  N  Y N 299 
HIS   CD2  C  Y N 300 
HIS   CE1  C  Y N 301 
HIS   NE2  N  Y N 302 
HIS   OXT  O  N N 303 
HIS   H    H  N N 304 
HIS   H2   H  N N 305 
HIS   HA   H  N N 306 
HIS   HB2  H  N N 307 
HIS   HB3  H  N N 308 
HIS   HD1  H  N N 309 
HIS   HD2  H  N N 310 
HIS   HE1  H  N N 311 
HIS   HE2  H  N N 312 
HIS   HXT  H  N N 313 
HOH   O    O  N N 314 
HOH   H1   H  N N 315 
HOH   H2   H  N N 316 
ILE   N    N  N N 317 
ILE   CA   C  N S 318 
ILE   C    C  N N 319 
ILE   O    O  N N 320 
ILE   CB   C  N S 321 
ILE   CG1  C  N N 322 
ILE   CG2  C  N N 323 
ILE   CD1  C  N N 324 
ILE   OXT  O  N N 325 
ILE   H    H  N N 326 
ILE   H2   H  N N 327 
ILE   HA   H  N N 328 
ILE   HB   H  N N 329 
ILE   HG12 H  N N 330 
ILE   HG13 H  N N 331 
ILE   HG21 H  N N 332 
ILE   HG22 H  N N 333 
ILE   HG23 H  N N 334 
ILE   HD11 H  N N 335 
ILE   HD12 H  N N 336 
ILE   HD13 H  N N 337 
ILE   HXT  H  N N 338 
LEU   N    N  N N 339 
LEU   CA   C  N S 340 
LEU   C    C  N N 341 
LEU   O    O  N N 342 
LEU   CB   C  N N 343 
LEU   CG   C  N N 344 
LEU   CD1  C  N N 345 
LEU   CD2  C  N N 346 
LEU   OXT  O  N N 347 
LEU   H    H  N N 348 
LEU   H2   H  N N 349 
LEU   HA   H  N N 350 
LEU   HB2  H  N N 351 
LEU   HB3  H  N N 352 
LEU   HG   H  N N 353 
LEU   HD11 H  N N 354 
LEU   HD12 H  N N 355 
LEU   HD13 H  N N 356 
LEU   HD21 H  N N 357 
LEU   HD22 H  N N 358 
LEU   HD23 H  N N 359 
LEU   HXT  H  N N 360 
LYS   N    N  N N 361 
LYS   CA   C  N S 362 
LYS   C    C  N N 363 
LYS   O    O  N N 364 
LYS   CB   C  N N 365 
LYS   CG   C  N N 366 
LYS   CD   C  N N 367 
LYS   CE   C  N N 368 
LYS   NZ   N  N N 369 
LYS   OXT  O  N N 370 
LYS   H    H  N N 371 
LYS   H2   H  N N 372 
LYS   HA   H  N N 373 
LYS   HB2  H  N N 374 
LYS   HB3  H  N N 375 
LYS   HG2  H  N N 376 
LYS   HG3  H  N N 377 
LYS   HD2  H  N N 378 
LYS   HD3  H  N N 379 
LYS   HE2  H  N N 380 
LYS   HE3  H  N N 381 
LYS   HZ1  H  N N 382 
LYS   HZ2  H  N N 383 
LYS   HZ3  H  N N 384 
LYS   HXT  H  N N 385 
MET   N    N  N N 386 
MET   CA   C  N S 387 
MET   C    C  N N 388 
MET   O    O  N N 389 
MET   CB   C  N N 390 
MET   CG   C  N N 391 
MET   SD   S  N N 392 
MET   CE   C  N N 393 
MET   OXT  O  N N 394 
MET   H    H  N N 395 
MET   H2   H  N N 396 
MET   HA   H  N N 397 
MET   HB2  H  N N 398 
MET   HB3  H  N N 399 
MET   HG2  H  N N 400 
MET   HG3  H  N N 401 
MET   HE1  H  N N 402 
MET   HE2  H  N N 403 
MET   HE3  H  N N 404 
MET   HXT  H  N N 405 
PHE   N    N  N N 406 
PHE   CA   C  N S 407 
PHE   C    C  N N 408 
PHE   O    O  N N 409 
PHE   CB   C  N N 410 
PHE   CG   C  Y N 411 
PHE   CD1  C  Y N 412 
PHE   CD2  C  Y N 413 
PHE   CE1  C  Y N 414 
PHE   CE2  C  Y N 415 
PHE   CZ   C  Y N 416 
PHE   OXT  O  N N 417 
PHE   H    H  N N 418 
PHE   H2   H  N N 419 
PHE   HA   H  N N 420 
PHE   HB2  H  N N 421 
PHE   HB3  H  N N 422 
PHE   HD1  H  N N 423 
PHE   HD2  H  N N 424 
PHE   HE1  H  N N 425 
PHE   HE2  H  N N 426 
PHE   HZ   H  N N 427 
PHE   HXT  H  N N 428 
PRO   N    N  N N 429 
PRO   CA   C  N S 430 
PRO   C    C  N N 431 
PRO   O    O  N N 432 
PRO   CB   C  N N 433 
PRO   CG   C  N N 434 
PRO   CD   C  N N 435 
PRO   OXT  O  N N 436 
PRO   H    H  N N 437 
PRO   HA   H  N N 438 
PRO   HB2  H  N N 439 
PRO   HB3  H  N N 440 
PRO   HG2  H  N N 441 
PRO   HG3  H  N N 442 
PRO   HD2  H  N N 443 
PRO   HD3  H  N N 444 
PRO   HXT  H  N N 445 
SER   N    N  N N 446 
SER   CA   C  N S 447 
SER   C    C  N N 448 
SER   O    O  N N 449 
SER   CB   C  N N 450 
SER   OG   O  N N 451 
SER   OXT  O  N N 452 
SER   H    H  N N 453 
SER   H2   H  N N 454 
SER   HA   H  N N 455 
SER   HB2  H  N N 456 
SER   HB3  H  N N 457 
SER   HG   H  N N 458 
SER   HXT  H  N N 459 
THR   N    N  N N 460 
THR   CA   C  N S 461 
THR   C    C  N N 462 
THR   O    O  N N 463 
THR   CB   C  N R 464 
THR   OG1  O  N N 465 
THR   CG2  C  N N 466 
THR   OXT  O  N N 467 
THR   H    H  N N 468 
THR   H2   H  N N 469 
THR   HA   H  N N 470 
THR   HB   H  N N 471 
THR   HG1  H  N N 472 
THR   HG21 H  N N 473 
THR   HG22 H  N N 474 
THR   HG23 H  N N 475 
THR   HXT  H  N N 476 
TRP   N    N  N N 477 
TRP   CA   C  N S 478 
TRP   C    C  N N 479 
TRP   O    O  N N 480 
TRP   CB   C  N N 481 
TRP   CG   C  Y N 482 
TRP   CD1  C  Y N 483 
TRP   CD2  C  Y N 484 
TRP   NE1  N  Y N 485 
TRP   CE2  C  Y N 486 
TRP   CE3  C  Y N 487 
TRP   CZ2  C  Y N 488 
TRP   CZ3  C  Y N 489 
TRP   CH2  C  Y N 490 
TRP   OXT  O  N N 491 
TRP   H    H  N N 492 
TRP   H2   H  N N 493 
TRP   HA   H  N N 494 
TRP   HB2  H  N N 495 
TRP   HB3  H  N N 496 
TRP   HD1  H  N N 497 
TRP   HE1  H  N N 498 
TRP   HE3  H  N N 499 
TRP   HZ2  H  N N 500 
TRP   HZ3  H  N N 501 
TRP   HH2  H  N N 502 
TRP   HXT  H  N N 503 
TYR   N    N  N N 504 
TYR   CA   C  N S 505 
TYR   C    C  N N 506 
TYR   O    O  N N 507 
TYR   CB   C  N N 508 
TYR   CG   C  Y N 509 
TYR   CD1  C  Y N 510 
TYR   CD2  C  Y N 511 
TYR   CE1  C  Y N 512 
TYR   CE2  C  Y N 513 
TYR   CZ   C  Y N 514 
TYR   OH   O  N N 515 
TYR   OXT  O  N N 516 
TYR   H    H  N N 517 
TYR   H2   H  N N 518 
TYR   HA   H  N N 519 
TYR   HB2  H  N N 520 
TYR   HB3  H  N N 521 
TYR   HD1  H  N N 522 
TYR   HD2  H  N N 523 
TYR   HE1  H  N N 524 
TYR   HE2  H  N N 525 
TYR   HH   H  N N 526 
TYR   HXT  H  N N 527 
VAL   N    N  N N 528 
VAL   CA   C  N S 529 
VAL   C    C  N N 530 
VAL   O    O  N N 531 
VAL   CB   C  N N 532 
VAL   CG1  C  N N 533 
VAL   CG2  C  N N 534 
VAL   OXT  O  N N 535 
VAL   H    H  N N 536 
VAL   H2   H  N N 537 
VAL   HA   H  N N 538 
VAL   HB   H  N N 539 
VAL   HG11 H  N N 540 
VAL   HG12 H  N N 541 
VAL   HG13 H  N N 542 
VAL   HG21 H  N N 543 
VAL   HG22 H  N N 544 
VAL   HG23 H  N N 545 
VAL   HXT  H  N N 546 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1ANM N02  C01  sing N N 1   
A1ANM C03  N02  sing N N 2   
A1ANM N05  C04  sing N N 3   
A1ANM C07  C06  doub Y N 4   
A1ANM C08  C07  sing Y N 5   
A1ANM C09  C08  doub Y N 6   
A1ANM C11  C10  doub Y N 7   
A1ANM F12  C11  sing N N 8   
A1ANM C13  C11  sing Y N 9   
A1ANM C14  C13  doub Y N 10  
A1ANM C15  C14  sing Y N 11  
A1ANM O17  C16  doub N N 12  
A1ANM N18  C16  sing N N 13  
A1ANM C19  N18  sing N N 14  
A1ANM C20  C19  sing N N 15  
A1ANM O21  C20  sing N N 16  
A1ANM C22  O21  sing N N 17  
A1ANM C23  C22  sing N N 18  
A1ANM O24  C23  sing N N 19  
A1ANM C25  O24  sing N N 20  
A1ANM C26  C25  sing N N 21  
A1ANM O27  C26  sing N N 22  
A1ANM C28  O27  sing N N 23  
A1ANM C29  C28  sing N N 24  
A1ANM O30  C29  sing N N 25  
A1ANM C31  O30  sing N N 26  
A1ANM C32  C31  sing N N 27  
A1ANM N33  C32  sing N N 28  
A1ANM C34  N33  sing N N 29  
A1ANM O35  C34  doub N N 30  
A1ANM C36  C34  sing N N 31  
A1ANM N37  C36  sing N N 32  
A1ANM C38  N37  sing Y N 33  
A1ANM C39  C38  doub Y N 34  
A1ANM N41  C40  sing Y N 35  
A1ANM C42  N41  sing Y N 36  
A1ANM C43  C42  doub Y N 37  
A1ANM O45  C44  doub N N 38  
A1ANM N46  C44  sing N N 39  
A1ANM C47  N46  sing N N 40  
A1ANM C49  C48  sing N N 41  
A1ANM O50  C49  doub N N 42  
A1ANM N51  C49  sing N N 43  
A1ANM C48  C47  sing N N 44  
A1ANM C52  C47  sing N N 45  
A1ANM C53  C52  doub Y N 46  
A1ANM C54  C53  sing Y N 47  
A1ANM CL55 C54  sing N N 48  
A1ANM C56  C54  doub Y N 49  
A1ANM F57  C56  sing N N 50  
A1ANM C58  C56  sing Y N 51  
A1ANM C59  C58  doub Y N 52  
A1ANM C44  C43  sing N N 53  
A1ANM C60  C43  sing Y N 54  
A1ANM C61  C60  sing N N 55  
A1ANM C62  C61  doub Y N 56  
A1ANM C63  C62  sing Y N 57  
A1ANM C64  C63  doub Y N 58  
A1ANM CL65 C64  sing N N 59  
A1ANM C66  C64  sing Y N 60  
A1ANM C67  C66  doub Y N 61  
A1ANM F68  C67  sing N N 62  
A1ANM C40  C39  sing N N 63  
A1ANM C69  C39  sing Y N 64  
A1ANM N70  C69  doub Y N 65  
A1ANM C16  C15  sing N N 66  
A1ANM C71  C15  doub Y N 67  
A1ANM C10  C09  sing N N 68  
A1ANM C72  C09  sing Y N 69  
A1ANM C73  C72  doub Y N 70  
A1ANM N74  C73  sing N N 71  
A1ANM C75  N74  sing N N 72  
A1ANM O76  C75  doub N N 73  
A1ANM C77  C75  sing N N 74  
A1ANM F80  C79  sing N N 75  
A1ANM F81  C79  sing N N 76  
A1ANM F82  C79  sing N N 77  
A1ANM C79  C78  sing N N 78  
A1ANM C83  C78  doub N N 79  
A1ANM C84  C83  sing N N 80  
A1ANM O85  C84  doub N N 81  
A1ANM N86  C84  sing N N 82  
A1ANM C78  C77  sing N N 83  
A1ANM C87  C77  doub N N 84  
A1ANM C06  N05  sing N N 85  
A1ANM C88  N05  sing N N 86  
A1ANM C89  C88  sing N N 87  
A1ANM C90  C89  sing N N 88  
A1ANM C04  C03  sing N N 89  
A1ANM C91  C03  sing N N 90  
A1ANM N02  C89  sing N N 91  
A1ANM C06  C73  sing Y N 92  
A1ANM C10  C71  sing Y N 93  
A1ANM N37  N70  sing Y N 94  
A1ANM C40  C60  doub Y N 95  
A1ANM C52  C59  sing Y N 96  
A1ANM C61  C67  sing Y N 97  
A1ANM N86  C87  sing N N 98  
A1ANM C01  H012 sing N N 99  
A1ANM C01  H011 sing N N 100 
A1ANM C01  H013 sing N N 101 
A1ANM C03  H031 sing N N 102 
A1ANM C04  H042 sing N N 103 
A1ANM C04  H041 sing N N 104 
A1ANM C07  H071 sing N N 105 
A1ANM C08  H081 sing N N 106 
A1ANM C13  H131 sing N N 107 
A1ANM C14  H141 sing N N 108 
A1ANM C19  H191 sing N N 109 
A1ANM C19  H192 sing N N 110 
A1ANM C20  H202 sing N N 111 
A1ANM C20  H201 sing N N 112 
A1ANM C22  H222 sing N N 113 
A1ANM C22  H221 sing N N 114 
A1ANM C23  H231 sing N N 115 
A1ANM C23  H232 sing N N 116 
A1ANM C25  H251 sing N N 117 
A1ANM C25  H252 sing N N 118 
A1ANM C26  H262 sing N N 119 
A1ANM C26  H261 sing N N 120 
A1ANM C28  H282 sing N N 121 
A1ANM C28  H281 sing N N 122 
A1ANM C29  H292 sing N N 123 
A1ANM C29  H291 sing N N 124 
A1ANM C31  H311 sing N N 125 
A1ANM C31  H312 sing N N 126 
A1ANM C32  H322 sing N N 127 
A1ANM C32  H321 sing N N 128 
A1ANM C36  H361 sing N N 129 
A1ANM C36  H362 sing N N 130 
A1ANM C38  H381 sing N N 131 
A1ANM C42  H421 sing N N 132 
A1ANM C47  H471 sing N N 133 
A1ANM C48  H481 sing N N 134 
A1ANM C48  H482 sing N N 135 
A1ANM C53  H531 sing N N 136 
A1ANM C58  H581 sing N N 137 
A1ANM C59  H591 sing N N 138 
A1ANM C62  H621 sing N N 139 
A1ANM C63  H631 sing N N 140 
A1ANM C66  H661 sing N N 141 
A1ANM C69  H691 sing N N 142 
A1ANM C71  H711 sing N N 143 
A1ANM C72  H721 sing N N 144 
A1ANM C83  H831 sing N N 145 
A1ANM C87  H871 sing N N 146 
A1ANM C88  H881 sing N N 147 
A1ANM C88  H882 sing N N 148 
A1ANM C89  H891 sing N N 149 
A1ANM C90  H901 sing N N 150 
A1ANM C90  H903 sing N N 151 
A1ANM C90  H902 sing N N 152 
A1ANM C91  H911 sing N N 153 
A1ANM C91  H912 sing N N 154 
A1ANM C91  H913 sing N N 155 
A1ANM N18  H181 sing N N 156 
A1ANM N33  H331 sing N N 157 
A1ANM N41  H411 sing N N 158 
A1ANM N46  H461 sing N N 159 
A1ANM N51  H511 sing N N 160 
A1ANM N51  H512 sing N N 161 
A1ANM N74  H741 sing N N 162 
A1ANM N86  H861 sing N N 163 
ALA   N    CA   sing N N 164 
ALA   N    H    sing N N 165 
ALA   N    H2   sing N N 166 
ALA   CA   C    sing N N 167 
ALA   CA   CB   sing N N 168 
ALA   CA   HA   sing N N 169 
ALA   C    O    doub N N 170 
ALA   C    OXT  sing N N 171 
ALA   CB   HB1  sing N N 172 
ALA   CB   HB2  sing N N 173 
ALA   CB   HB3  sing N N 174 
ALA   OXT  HXT  sing N N 175 
ARG   N    CA   sing N N 176 
ARG   N    H    sing N N 177 
ARG   N    H2   sing N N 178 
ARG   CA   C    sing N N 179 
ARG   CA   CB   sing N N 180 
ARG   CA   HA   sing N N 181 
ARG   C    O    doub N N 182 
ARG   C    OXT  sing N N 183 
ARG   CB   CG   sing N N 184 
ARG   CB   HB2  sing N N 185 
ARG   CB   HB3  sing N N 186 
ARG   CG   CD   sing N N 187 
ARG   CG   HG2  sing N N 188 
ARG   CG   HG3  sing N N 189 
ARG   CD   NE   sing N N 190 
ARG   CD   HD2  sing N N 191 
ARG   CD   HD3  sing N N 192 
ARG   NE   CZ   sing N N 193 
ARG   NE   HE   sing N N 194 
ARG   CZ   NH1  sing N N 195 
ARG   CZ   NH2  doub N N 196 
ARG   NH1  HH11 sing N N 197 
ARG   NH1  HH12 sing N N 198 
ARG   NH2  HH21 sing N N 199 
ARG   NH2  HH22 sing N N 200 
ARG   OXT  HXT  sing N N 201 
ASN   N    CA   sing N N 202 
ASN   N    H    sing N N 203 
ASN   N    H2   sing N N 204 
ASN   CA   C    sing N N 205 
ASN   CA   CB   sing N N 206 
ASN   CA   HA   sing N N 207 
ASN   C    O    doub N N 208 
ASN   C    OXT  sing N N 209 
ASN   CB   CG   sing N N 210 
ASN   CB   HB2  sing N N 211 
ASN   CB   HB3  sing N N 212 
ASN   CG   OD1  doub N N 213 
ASN   CG   ND2  sing N N 214 
ASN   ND2  HD21 sing N N 215 
ASN   ND2  HD22 sing N N 216 
ASN   OXT  HXT  sing N N 217 
ASP   N    CA   sing N N 218 
ASP   N    H    sing N N 219 
ASP   N    H2   sing N N 220 
ASP   CA   C    sing N N 221 
ASP   CA   CB   sing N N 222 
ASP   CA   HA   sing N N 223 
ASP   C    O    doub N N 224 
ASP   C    OXT  sing N N 225 
ASP   CB   CG   sing N N 226 
ASP   CB   HB2  sing N N 227 
ASP   CB   HB3  sing N N 228 
ASP   CG   OD1  doub N N 229 
ASP   CG   OD2  sing N N 230 
ASP   OD2  HD2  sing N N 231 
ASP   OXT  HXT  sing N N 232 
CYS   N    CA   sing N N 233 
CYS   N    H    sing N N 234 
CYS   N    H2   sing N N 235 
CYS   CA   C    sing N N 236 
CYS   CA   CB   sing N N 237 
CYS   CA   HA   sing N N 238 
CYS   C    O    doub N N 239 
CYS   C    OXT  sing N N 240 
CYS   CB   SG   sing N N 241 
CYS   CB   HB2  sing N N 242 
CYS   CB   HB3  sing N N 243 
CYS   SG   HG   sing N N 244 
CYS   OXT  HXT  sing N N 245 
GLN   N    CA   sing N N 246 
GLN   N    H    sing N N 247 
GLN   N    H2   sing N N 248 
GLN   CA   C    sing N N 249 
GLN   CA   CB   sing N N 250 
GLN   CA   HA   sing N N 251 
GLN   C    O    doub N N 252 
GLN   C    OXT  sing N N 253 
GLN   CB   CG   sing N N 254 
GLN   CB   HB2  sing N N 255 
GLN   CB   HB3  sing N N 256 
GLN   CG   CD   sing N N 257 
GLN   CG   HG2  sing N N 258 
GLN   CG   HG3  sing N N 259 
GLN   CD   OE1  doub N N 260 
GLN   CD   NE2  sing N N 261 
GLN   NE2  HE21 sing N N 262 
GLN   NE2  HE22 sing N N 263 
GLN   OXT  HXT  sing N N 264 
GLU   N    CA   sing N N 265 
GLU   N    H    sing N N 266 
GLU   N    H2   sing N N 267 
GLU   CA   C    sing N N 268 
GLU   CA   CB   sing N N 269 
GLU   CA   HA   sing N N 270 
GLU   C    O    doub N N 271 
GLU   C    OXT  sing N N 272 
GLU   CB   CG   sing N N 273 
GLU   CB   HB2  sing N N 274 
GLU   CB   HB3  sing N N 275 
GLU   CG   CD   sing N N 276 
GLU   CG   HG2  sing N N 277 
GLU   CG   HG3  sing N N 278 
GLU   CD   OE1  doub N N 279 
GLU   CD   OE2  sing N N 280 
GLU   OE2  HE2  sing N N 281 
GLU   OXT  HXT  sing N N 282 
GLY   N    CA   sing N N 283 
GLY   N    H    sing N N 284 
GLY   N    H2   sing N N 285 
GLY   CA   C    sing N N 286 
GLY   CA   HA2  sing N N 287 
GLY   CA   HA3  sing N N 288 
GLY   C    O    doub N N 289 
GLY   C    OXT  sing N N 290 
GLY   OXT  HXT  sing N N 291 
HIS   N    CA   sing N N 292 
HIS   N    H    sing N N 293 
HIS   N    H2   sing N N 294 
HIS   CA   C    sing N N 295 
HIS   CA   CB   sing N N 296 
HIS   CA   HA   sing N N 297 
HIS   C    O    doub N N 298 
HIS   C    OXT  sing N N 299 
HIS   CB   CG   sing N N 300 
HIS   CB   HB2  sing N N 301 
HIS   CB   HB3  sing N N 302 
HIS   CG   ND1  sing Y N 303 
HIS   CG   CD2  doub Y N 304 
HIS   ND1  CE1  doub Y N 305 
HIS   ND1  HD1  sing N N 306 
HIS   CD2  NE2  sing Y N 307 
HIS   CD2  HD2  sing N N 308 
HIS   CE1  NE2  sing Y N 309 
HIS   CE1  HE1  sing N N 310 
HIS   NE2  HE2  sing N N 311 
HIS   OXT  HXT  sing N N 312 
HOH   O    H1   sing N N 313 
HOH   O    H2   sing N N 314 
ILE   N    CA   sing N N 315 
ILE   N    H    sing N N 316 
ILE   N    H2   sing N N 317 
ILE   CA   C    sing N N 318 
ILE   CA   CB   sing N N 319 
ILE   CA   HA   sing N N 320 
ILE   C    O    doub N N 321 
ILE   C    OXT  sing N N 322 
ILE   CB   CG1  sing N N 323 
ILE   CB   CG2  sing N N 324 
ILE   CB   HB   sing N N 325 
ILE   CG1  CD1  sing N N 326 
ILE   CG1  HG12 sing N N 327 
ILE   CG1  HG13 sing N N 328 
ILE   CG2  HG21 sing N N 329 
ILE   CG2  HG22 sing N N 330 
ILE   CG2  HG23 sing N N 331 
ILE   CD1  HD11 sing N N 332 
ILE   CD1  HD12 sing N N 333 
ILE   CD1  HD13 sing N N 334 
ILE   OXT  HXT  sing N N 335 
LEU   N    CA   sing N N 336 
LEU   N    H    sing N N 337 
LEU   N    H2   sing N N 338 
LEU   CA   C    sing N N 339 
LEU   CA   CB   sing N N 340 
LEU   CA   HA   sing N N 341 
LEU   C    O    doub N N 342 
LEU   C    OXT  sing N N 343 
LEU   CB   CG   sing N N 344 
LEU   CB   HB2  sing N N 345 
LEU   CB   HB3  sing N N 346 
LEU   CG   CD1  sing N N 347 
LEU   CG   CD2  sing N N 348 
LEU   CG   HG   sing N N 349 
LEU   CD1  HD11 sing N N 350 
LEU   CD1  HD12 sing N N 351 
LEU   CD1  HD13 sing N N 352 
LEU   CD2  HD21 sing N N 353 
LEU   CD2  HD22 sing N N 354 
LEU   CD2  HD23 sing N N 355 
LEU   OXT  HXT  sing N N 356 
LYS   N    CA   sing N N 357 
LYS   N    H    sing N N 358 
LYS   N    H2   sing N N 359 
LYS   CA   C    sing N N 360 
LYS   CA   CB   sing N N 361 
LYS   CA   HA   sing N N 362 
LYS   C    O    doub N N 363 
LYS   C    OXT  sing N N 364 
LYS   CB   CG   sing N N 365 
LYS   CB   HB2  sing N N 366 
LYS   CB   HB3  sing N N 367 
LYS   CG   CD   sing N N 368 
LYS   CG   HG2  sing N N 369 
LYS   CG   HG3  sing N N 370 
LYS   CD   CE   sing N N 371 
LYS   CD   HD2  sing N N 372 
LYS   CD   HD3  sing N N 373 
LYS   CE   NZ   sing N N 374 
LYS   CE   HE2  sing N N 375 
LYS   CE   HE3  sing N N 376 
LYS   NZ   HZ1  sing N N 377 
LYS   NZ   HZ2  sing N N 378 
LYS   NZ   HZ3  sing N N 379 
LYS   OXT  HXT  sing N N 380 
MET   N    CA   sing N N 381 
MET   N    H    sing N N 382 
MET   N    H2   sing N N 383 
MET   CA   C    sing N N 384 
MET   CA   CB   sing N N 385 
MET   CA   HA   sing N N 386 
MET   C    O    doub N N 387 
MET   C    OXT  sing N N 388 
MET   CB   CG   sing N N 389 
MET   CB   HB2  sing N N 390 
MET   CB   HB3  sing N N 391 
MET   CG   SD   sing N N 392 
MET   CG   HG2  sing N N 393 
MET   CG   HG3  sing N N 394 
MET   SD   CE   sing N N 395 
MET   CE   HE1  sing N N 396 
MET   CE   HE2  sing N N 397 
MET   CE   HE3  sing N N 398 
MET   OXT  HXT  sing N N 399 
PHE   N    CA   sing N N 400 
PHE   N    H    sing N N 401 
PHE   N    H2   sing N N 402 
PHE   CA   C    sing N N 403 
PHE   CA   CB   sing N N 404 
PHE   CA   HA   sing N N 405 
PHE   C    O    doub N N 406 
PHE   C    OXT  sing N N 407 
PHE   CB   CG   sing N N 408 
PHE   CB   HB2  sing N N 409 
PHE   CB   HB3  sing N N 410 
PHE   CG   CD1  doub Y N 411 
PHE   CG   CD2  sing Y N 412 
PHE   CD1  CE1  sing Y N 413 
PHE   CD1  HD1  sing N N 414 
PHE   CD2  CE2  doub Y N 415 
PHE   CD2  HD2  sing N N 416 
PHE   CE1  CZ   doub Y N 417 
PHE   CE1  HE1  sing N N 418 
PHE   CE2  CZ   sing Y N 419 
PHE   CE2  HE2  sing N N 420 
PHE   CZ   HZ   sing N N 421 
PHE   OXT  HXT  sing N N 422 
PRO   N    CA   sing N N 423 
PRO   N    CD   sing N N 424 
PRO   N    H    sing N N 425 
PRO   CA   C    sing N N 426 
PRO   CA   CB   sing N N 427 
PRO   CA   HA   sing N N 428 
PRO   C    O    doub N N 429 
PRO   C    OXT  sing N N 430 
PRO   CB   CG   sing N N 431 
PRO   CB   HB2  sing N N 432 
PRO   CB   HB3  sing N N 433 
PRO   CG   CD   sing N N 434 
PRO   CG   HG2  sing N N 435 
PRO   CG   HG3  sing N N 436 
PRO   CD   HD2  sing N N 437 
PRO   CD   HD3  sing N N 438 
PRO   OXT  HXT  sing N N 439 
SER   N    CA   sing N N 440 
SER   N    H    sing N N 441 
SER   N    H2   sing N N 442 
SER   CA   C    sing N N 443 
SER   CA   CB   sing N N 444 
SER   CA   HA   sing N N 445 
SER   C    O    doub N N 446 
SER   C    OXT  sing N N 447 
SER   CB   OG   sing N N 448 
SER   CB   HB2  sing N N 449 
SER   CB   HB3  sing N N 450 
SER   OG   HG   sing N N 451 
SER   OXT  HXT  sing N N 452 
THR   N    CA   sing N N 453 
THR   N    H    sing N N 454 
THR   N    H2   sing N N 455 
THR   CA   C    sing N N 456 
THR   CA   CB   sing N N 457 
THR   CA   HA   sing N N 458 
THR   C    O    doub N N 459 
THR   C    OXT  sing N N 460 
THR   CB   OG1  sing N N 461 
THR   CB   CG2  sing N N 462 
THR   CB   HB   sing N N 463 
THR   OG1  HG1  sing N N 464 
THR   CG2  HG21 sing N N 465 
THR   CG2  HG22 sing N N 466 
THR   CG2  HG23 sing N N 467 
THR   OXT  HXT  sing N N 468 
TRP   N    CA   sing N N 469 
TRP   N    H    sing N N 470 
TRP   N    H2   sing N N 471 
TRP   CA   C    sing N N 472 
TRP   CA   CB   sing N N 473 
TRP   CA   HA   sing N N 474 
TRP   C    O    doub N N 475 
TRP   C    OXT  sing N N 476 
TRP   CB   CG   sing N N 477 
TRP   CB   HB2  sing N N 478 
TRP   CB   HB3  sing N N 479 
TRP   CG   CD1  doub Y N 480 
TRP   CG   CD2  sing Y N 481 
TRP   CD1  NE1  sing Y N 482 
TRP   CD1  HD1  sing N N 483 
TRP   CD2  CE2  doub Y N 484 
TRP   CD2  CE3  sing Y N 485 
TRP   NE1  CE2  sing Y N 486 
TRP   NE1  HE1  sing N N 487 
TRP   CE2  CZ2  sing Y N 488 
TRP   CE3  CZ3  doub Y N 489 
TRP   CE3  HE3  sing N N 490 
TRP   CZ2  CH2  doub Y N 491 
TRP   CZ2  HZ2  sing N N 492 
TRP   CZ3  CH2  sing Y N 493 
TRP   CZ3  HZ3  sing N N 494 
TRP   CH2  HH2  sing N N 495 
TRP   OXT  HXT  sing N N 496 
TYR   N    CA   sing N N 497 
TYR   N    H    sing N N 498 
TYR   N    H2   sing N N 499 
TYR   CA   C    sing N N 500 
TYR   CA   CB   sing N N 501 
TYR   CA   HA   sing N N 502 
TYR   C    O    doub N N 503 
TYR   C    OXT  sing N N 504 
TYR   CB   CG   sing N N 505 
TYR   CB   HB2  sing N N 506 
TYR   CB   HB3  sing N N 507 
TYR   CG   CD1  doub Y N 508 
TYR   CG   CD2  sing Y N 509 
TYR   CD1  CE1  sing Y N 510 
TYR   CD1  HD1  sing N N 511 
TYR   CD2  CE2  doub Y N 512 
TYR   CD2  HD2  sing N N 513 
TYR   CE1  CZ   doub Y N 514 
TYR   CE1  HE1  sing N N 515 
TYR   CE2  CZ   sing Y N 516 
TYR   CE2  HE2  sing N N 517 
TYR   CZ   OH   sing N N 518 
TYR   OH   HH   sing N N 519 
TYR   OXT  HXT  sing N N 520 
VAL   N    CA   sing N N 521 
VAL   N    H    sing N N 522 
VAL   N    H2   sing N N 523 
VAL   CA   C    sing N N 524 
VAL   CA   CB   sing N N 525 
VAL   CA   HA   sing N N 526 
VAL   C    O    doub N N 527 
VAL   C    OXT  sing N N 528 
VAL   CB   CG1  sing N N 529 
VAL   CB   CG2  sing N N 530 
VAL   CB   HB   sing N N 531 
VAL   CG1  HG11 sing N N 532 
VAL   CG1  HG12 sing N N 533 
VAL   CG1  HG13 sing N N 534 
VAL   CG2  HG21 sing N N 535 
VAL   CG2  HG22 sing N N 536 
VAL   CG2  HG23 sing N N 537 
VAL   OXT  HXT  sing N N 538 
# 
_pdbx_audit_support.funding_organization   'Ontario Institute for Cancer Research' 
_pdbx_audit_support.country                Canada 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
loop_
_pdbx_initial_refinement_model.id 
_pdbx_initial_refinement_model.entity_id_list 
_pdbx_initial_refinement_model.type 
_pdbx_initial_refinement_model.source_name 
_pdbx_initial_refinement_model.accession_code 
_pdbx_initial_refinement_model.details 
1 ? 'experimental model' PDB 8F8E ? 
2 ? 'experimental model' PDB 2GNQ ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9B9T 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.012521 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.011945 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.007685 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
CL ? ? 9.50761 7.44341 ? ? 1.04373  23.83732 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F  ? ? 4.90428 4.07044 ? ? 12.99538 1.63651  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N    . PRO   A 1 25  ? -5.37199  4.29745   19.45162  1.000 89.60349  ? 30   PRO   A N    1 
ATOM   2    C  CA   . PRO   A 1 25  ? -5.78110  2.95152   19.03052  1.000 86.89205  ? 30   PRO   A CA   1 
ATOM   3    C  C    . PRO   A 1 25  ? -4.62820  1.93240   19.07050  1.000 77.50357  ? 30   PRO   A C    1 
ATOM   4    O  O    . PRO   A 1 25  ? -3.67216  2.04536   18.30054  1.000 70.25500  ? 30   PRO   A O    1 
ATOM   5    C  CB   . PRO   A 1 25  ? -6.27002  3.17566   17.59051  1.000 86.28819  ? 30   PRO   A CB   1 
ATOM   6    C  CG   . PRO   A 1 25  ? -5.44989  4.32961   17.10362  1.000 87.23030  ? 30   PRO   A CG   1 
ATOM   7    C  CD   . PRO   A 1 25  ? -5.24385  5.22251   18.30968  1.000 91.92336  ? 30   PRO   A CD   1 
ATOM   8    N  N    . VAL   A 1 26  ? -4.72433  0.94336   19.95843  1.000 70.10321  ? 31   VAL   A N    1 
ATOM   9    C  CA   . VAL   A 1 26  ? -3.67043  -0.05575  20.07841  1.000 63.25998  ? 31   VAL   A CA   1 
ATOM   10   C  C    . VAL   A 1 26  ? -3.58246  -0.87968  18.79636  1.000 63.67464  ? 31   VAL   A C    1 
ATOM   11   O  O    . VAL   A 1 26  ? -4.59947  -1.20754  18.17030  1.000 59.09981  ? 31   VAL   A O    1 
ATOM   12   C  CB   . VAL   A 1 26  ? -3.92257  -0.94080  21.31334  1.000 66.23697  ? 31   VAL   A CB   1 
ATOM   13   C  CG1  . VAL   A 1 26  ? -5.33662  -1.53767  21.27925  1.000 68.78817  ? 31   VAL   A CG1  1 
ATOM   14   C  CG2  . VAL   A 1 26  ? -2.86767  -2.02291  21.41632  1.000 63.27337  ? 31   VAL   A CG2  1 
ATOM   15   N  N    . LYS   A 1 27  ? -2.35148  -1.18877  18.37839  1.000 54.23772  ? 32   LYS   A N    1 
ATOM   16   C  CA   . LYS   A 1 27  ? -2.05952  -2.03573  17.23634  1.000 46.32843  ? 32   LYS   A CA   1 
ATOM   17   C  C    . LYS   A 1 27  ? -1.21765  -3.22284  17.68030  1.000 47.85444  ? 32   LYS   A C    1 
ATOM   18   O  O    . LYS   A 1 27  ? -0.40067  -3.09098  18.60034  1.000 43.40910  ? 32   LYS   A O    1 
ATOM   19   C  CB   . LYS   A 1 27  ? -1.29240  -1.29074  16.13942  1.000 46.32386  ? 32   LYS   A CB   1 
ATOM   20   C  CG   . LYS   A 1 27  ? -2.13529  -0.50359  15.15344  1.000 53.34575  ? 32   LYS   A CG   1 
ATOM   21   C  CD   . LYS   A 1 27  ? -1.22819  0.11939   14.08151  1.000 59.03395  ? 32   LYS   A CD   1 
ATOM   22   C  CE   . LYS   A 1 27  ? -2.00107  0.94853   13.05253  1.000 60.43997  ? 32   LYS   A CE   1 
ATOM   23   N  NZ   . LYS   A 1 27  ? -2.30895  2.33653   13.52161  1.000 62.52160  ? 32   LYS   A NZ   1 
ATOM   24   N  N    . PRO   A 1 28  ? -1.37774  -4.38478  17.04822  1.000 40.08515  ? 33   PRO   A N    1 
ATOM   25   C  CA   . PRO   A 1 28  ? -0.47686  -5.51089  17.31919  1.000 38.00174  ? 33   PRO   A CA   1 
ATOM   26   C  C    . PRO   A 1 28  ? 0.86419   -5.30198  16.62425  1.000 32.99575  ? 33   PRO   A C    1 
ATOM   27   O  O    . PRO   A 1 28  ? 1.02330   -4.45094  15.75031  1.000 32.46122  ? 33   PRO   A O    1 
ATOM   28   C  CB   . PRO   A 1 28  ? -1.23295  -6.71478  16.74008  1.000 38.35178  ? 33   PRO   A CB   1 
ATOM   29   C  CG   . PRO   A 1 28  ? -1.98685  -6.12763  15.56409  1.000 36.80332  ? 33   PRO   A CG   1 
ATOM   30   C  CD   . PRO   A 1 28  ? -2.38073  -4.71762  16.01716  1.000 39.77909  ? 33   PRO   A CD   1 
ATOM   31   N  N    . ASN   A 1 29  ? 1.84710   -6.08710  17.03924  1.000 35.15892  ? 34   ASN   A N    1 
ATOM   32   C  CA   . ASN   A 1 29  ? 3.18213   -6.02019  16.45129  1.000 35.11131  ? 34   ASN   A CA   1 
ATOM   33   C  C    . ASN   A 1 29  ? 3.65800   -7.41121  16.11322  1.000 36.64826  ? 34   ASN   A C    1 
ATOM   34   O  O    . ASN   A 1 29  ? 4.71994   -7.85235  16.55424  1.000 39.60501  ? 34   ASN   A O    1 
ATOM   35   C  CB   . ASN   A 1 29  ? 4.18516   -5.33235  17.37937  1.000 34.60706  ? 34   ASN   A CB   1 
ATOM   36   C  CG   . ASN   A 1 29  ? 4.30304   -6.02944  18.74034  1.000 36.45501  ? 34   ASN   A CG   1 
ATOM   37   O  OD1  . ASN   A 1 29  ? 3.48994   -6.89339  19.08725  1.000 41.22181  ? 34   ASN   A OD1  1 
ATOM   38   N  ND2  . ASN   A 1 29  ? 5.30404   -5.65259  19.51140  1.000 37.68114  ? 34   ASN   A ND2  1 
ATOM   39   N  N    . TYR   A 1 30  ? 2.85496   -8.14209  15.33415  1.000 33.35353  ? 35   TYR   A N    1 
ATOM   40   C  CA   . TYR   A 1 30  ? 3.24784   -9.49410  14.94808  1.000 33.85048  ? 35   TYR   A CA   1 
ATOM   41   C  C    . TYR   A 1 30  ? 4.57488   -9.46418  14.19613  1.000 30.01936  ? 35   TYR   A C    1 
ATOM   42   O  O    . TYR   A 1 30  ? 4.76899   -8.65915  13.28619  1.000 37.13502  ? 35   TYR   A O    1 
ATOM   43   C  CB   . TYR   A 1 30  ? 2.15381   -10.14894 14.09899  1.000 30.41459  ? 35   TYR   A CB   1 
ATOM   44   C  CG   . TYR   A 1 30  ? 1.08972   -10.75889 14.95392  1.000 30.11291  ? 35   TYR   A CG   1 
ATOM   45   C  CD1  . TYR   A 1 30  ? 1.29158   -11.99295 15.56685  1.000 27.75303  ? 35   TYR   A CD1  1 
ATOM   46   C  CD2  . TYR   A 1 30  ? -0.08022  -10.06680 15.23192  1.000 28.93050  ? 35   TYR   A CD2  1 
ATOM   47   C  CE1  . TYR   A 1 30  ? 0.32049   -12.55191 16.38677  1.000 27.57576  ? 35   TYR   A CE1  1 
ATOM   48   C  CE2  . TYR   A 1 30  ? -1.06131  -10.61075 16.06184  1.000 30.35227  ? 35   TYR   A CE2  1 
ATOM   49   C  CZ   . TYR   A 1 30  ? -0.86245  -11.85281 16.62577  1.000 28.65938  ? 35   TYR   A CZ   1 
ATOM   50   O  OH   . TYR   A 1 30  ? -1.84153  -12.39676 17.45370  1.000 28.72326  ? 35   TYR   A OH   1 
ATOM   51   N  N    . ALA   A 1 31  ? 5.49478   -10.34130 14.59611  1.000 31.38628  ? 36   ALA   A N    1 
ATOM   52   C  CA   . ALA   A 1 31  ? 6.80079   -10.43539 13.97515  1.000 29.27817  ? 36   ALA   A CA   1 
ATOM   53   C  C    . ALA   A 1 31  ? 7.13866   -11.89840 13.73507  1.000 31.23017  ? 36   ALA   A C    1 
ATOM   54   O  O    . ALA   A 1 31  ? 6.74354   -12.77841 14.50200  1.000 30.47831  ? 36   ALA   A O    1 
ATOM   55   C  CB   . ALA   A 1 31  ? 7.88082   -9.78255  14.84424  1.000 36.32029  ? 36   ALA   A CB   1 
ATOM   56   N  N    . LEU   A 1 32  ? 7.86767   -12.14541 12.65709  1.000 31.43201  ? 37   LEU   A N    1 
ATOM   57   C  CA   . LEU   A 1 32  ? 8.14056   -13.50441 12.22801  1.000 31.08186  ? 37   LEU   A CA   1 
ATOM   58   C  C    . LEU   A 1 32  ? 9.10145   -14.19856 13.19400  1.000 38.17671  ? 37   LEU   A C    1 
ATOM   59   O  O    . LEU   A 1 32  ? 10.20149  -13.70168 13.46008  1.000 32.36877  ? 37   LEU   A O    1 
ATOM   60   C  CB   . LEU   A 1 32  ? 8.73061   -13.48138 10.82704  1.000 27.66291  ? 37   LEU   A CB   1 
ATOM   61   C  CG   . LEU   A 1 32  ? 9.07050   -14.85337 10.28096  1.000 30.53974  ? 37   LEU   A CG   1 
ATOM   62   C  CD1  . LEU   A 1 32  ? 7.79243   -15.66324 10.13686  1.000 31.41552  ? 37   LEU   A CD1  1 
ATOM   63   C  CD2  . LEU   A 1 32  ? 9.75357   -14.69736 8.95400   1.000 30.72932  ? 37   LEU   A CD2  1 
ATOM   64   N  N    . LYS   A 1 33  ? 8.69232   -15.35855 13.70492  1.000 32.51402  ? 38   LYS   A N    1 
ATOM   65   C  CA   . LYS   A 1 33  ? 9.50821   -16.14569 14.62190  1.000 34.89819  ? 38   LYS   A CA   1 
ATOM   66   C  C    . LYS   A 1 33  ? 10.07711  -17.40971 13.99784  1.000 36.00531  ? 38   LYS   A C    1 
ATOM   67   O  O    . LYS   A 1 33  ? 11.24307  -17.73283 14.22886  1.000 36.74165  ? 38   LYS   A O    1 
ATOM   68   C  CB   . LYS   A 1 33  ? 8.68713   -16.52469 15.86084  1.000 29.02080  ? 38   LYS   A CB   1 
ATOM   69   C  CG   . LYS   A 1 33  ? 8.02222   -15.35766 16.51489  1.000 34.65346  ? 38   LYS   A CG   1 
ATOM   70   C  CD   . LYS   A 1 33  ? 8.55418   -15.13980 17.91592  1.000 41.71526  ? 38   LYS   A CD   1 
ATOM   71   C  CE   . LYS   A 1 33  ? 10.01722  -14.76795 17.91700  1.000 40.77272  ? 38   LYS   A CE   1 
ATOM   72   N  NZ   . LYS   A 1 33  ? 10.43120  -14.43007 19.30304  1.000 41.92876  ? 38   LYS   A NZ   1 
ATOM   73   N  N    . PHE   A 1 34  ? 9.29107   -18.14658 13.21676  1.000 35.23461  ? 39   PHE   A N    1 
ATOM   74   C  CA   . PHE   A 1 34  ? 9.79598   -19.35359 12.57371  1.000 33.42304  ? 39   PHE   A CA   1 
ATOM   75   C  C    . PHE   A 1 34  ? 9.15701   -19.51744 11.20167  1.000 33.07080  ? 39   PHE   A C    1 
ATOM   76   O  O    . PHE   A 1 34  ? 8.00806   -19.11732 10.98365  1.000 33.41088  ? 39   PHE   A O    1 
ATOM   77   C  CB   . PHE   A 1 34  ? 9.50382   -20.60461 13.40762  1.000 36.24254  ? 39   PHE   A CB   1 
ATOM   78   C  CG   . PHE   A 1 34  ? 10.02478  -20.53275 14.80964  1.000 39.25190  ? 39   PHE   A CG   1 
ATOM   79   C  CD1  . PHE   A 1 34  ? 11.38475  -20.70990 15.06368  1.000 39.14906  ? 39   PHE   A CD1  1 
ATOM   80   C  CD2  . PHE   A 1 34  ? 9.16176   -20.30273 15.87462  1.000 35.74441  ? 39   PHE   A CD2  1 
ATOM   81   C  CE1  . PHE   A 1 34  ? 11.87271  -20.64603 16.33670  1.000 36.47436  ? 39   PHE   A CE1  1 
ATOM   82   C  CE2  . PHE   A 1 34  ? 9.64771   -20.25086 17.16764  1.000 38.63138  ? 39   PHE   A CE2  1 
ATOM   83   C  CZ   . PHE   A 1 34  ? 11.00769  -20.42701 17.39868  1.000 37.03602  ? 39   PHE   A CZ   1 
ATOM   84   N  N    . THR   A 1 35  ? 9.90599   -20.13946 10.29066  1.000 32.37227  ? 40   THR   A N    1 
ATOM   85   C  CA   . THR   A 1 35  ? 9.39899   -20.59033 9.00161   1.000 31.58364  ? 40   THR   A CA   1 
ATOM   86   C  C    . THR   A 1 35  ? 9.51085   -22.10633 8.96152   1.000 35.77382  ? 40   THR   A C    1 
ATOM   87   O  O    . THR   A 1 35  ? 10.59879  -22.65245 9.14753   1.000 34.47781  ? 40   THR   A O    1 
ATOM   88   C  CB   . THR   A 1 35  ? 10.17810  -19.94533 7.85468   1.000 30.59740  ? 40   THR   A CB   1 
ATOM   89   O  OG1  . THR   A 1 35  ? 9.98323   -18.53531 7.92476   1.000 29.47757  ? 40   THR   A OG1  1 
ATOM   90   C  CG2  . THR   A 1 35  ? 9.69410   -20.45420 6.51763   1.000 28.41881  ? 40   THR   A CG2  1 
ATOM   91   N  N    . LEU   A 1 36  ? 8.39079   -22.77921 8.73644   1.000 27.98106  ? 41   LEU   A N    1 
ATOM   92   C  CA   . LEU   A 1 36  ? 8.30965   -24.22821 8.82034   1.000 30.96824  ? 41   LEU   A CA   1 
ATOM   93   C  C    . LEU   A 1 36  ? 8.34465   -24.77212 7.40431   1.000 33.21835  ? 41   LEU   A C    1 
ATOM   94   O  O    . LEU   A 1 36  ? 7.38769   -24.59598 6.64429   1.000 31.13461  ? 41   LEU   A O    1 
ATOM   95   C  CB   . LEU   A 1 36  ? 7.04457   -24.67213 9.54827   1.000 29.34407  ? 41   LEU   A CB   1 
ATOM   96   C  CG   . LEU   A 1 36  ? 7.02153   -24.55923 11.07427  1.000 38.31357  ? 41   LEU   A CG   1 
ATOM   97   C  CD1  . LEU   A 1 36  ? 7.60964   -23.23231 11.54938  1.000 37.51222  ? 41   LEU   A CD1  1 
ATOM   98   C  CD2  . LEU   A 1 36  ? 5.58549   -24.76212 11.60021  1.000 27.30991  ? 41   LEU   A CD2  1 
ATOM   99   N  N    . ALA   A 1 37  ? 9.44660   -25.42321 7.04631   1.000 33.26207  ? 42   ALA   A N    1 
ATOM   100  C  CA   . ALA   A 1 37  ? 9.62159   -26.01214 5.73128   1.000 29.83032  ? 42   ALA   A CA   1 
ATOM   101  C  C    . ALA   A 1 37  ? 9.52644   -27.53214 5.82818   1.000 35.38946  ? 42   ALA   A C    1 
ATOM   102  O  O    . ALA   A 1 37  ? 9.88834   -28.13524 6.84516   1.000 36.75222  ? 42   ALA   A O    1 
ATOM   103  C  CB   . ALA   A 1 37  ? 10.95965  -25.58723 5.12736   1.000 35.10360  ? 42   ALA   A CB   1 
ATOM   104  N  N    . GLY   A 1 38  ? 9.03542   -28.15802 4.76312   1.000 30.90615  ? 43   GLY   A N    1 
ATOM   105  C  CA   . GLY   A 1 38  ? 8.82328   -29.58701 4.83703   1.000 30.73379  ? 43   GLY   A CA   1 
ATOM   106  C  C    . GLY   A 1 38  ? 7.81926   -30.12085 3.84095   1.000 36.30456  ? 43   GLY   A C    1 
ATOM   107  O  O    . GLY   A 1 38  ? 8.06618   -31.15983 3.22190   1.000 31.20997  ? 43   GLY   A O    1 
ATOM   108  N  N    . HIS   A 1 39  ? 6.67833   -29.45073 3.69095   1.000 32.14560  ? 44   HIS   A N    1 
ATOM   109  C  CA   . HIS   A 1 39  ? 5.75033   -29.86057 2.65389   1.000 31.79342  ? 44   HIS   A CA   1 
ATOM   110  C  C    . HIS   A 1 39  ? 6.36641   -29.60155 1.28593   1.000 27.11835  ? 44   HIS   A C    1 
ATOM   111  O  O    . HIS   A 1 39  ? 7.11451   -28.64161 1.09102   1.000 30.34384  ? 44   HIS   A O    1 
ATOM   112  C  CB   . HIS   A 1 39  ? 4.41540   -29.12545 2.79789   1.000 28.11857  ? 44   HIS   A CB   1 
ATOM   113  C  CG   . HIS   A 1 39  ? 3.56430   -29.64444 3.91382   1.000 24.72105  ? 44   HIS   A CG   1 
ATOM   114  N  ND1  . HIS   A 1 39  ? 2.93619   -30.87037 3.86272   1.000 24.88973  ? 44   HIS   A ND1  1 
ATOM   115  C  CD2  . HIS   A 1 39  ? 3.24731   -29.10848 5.11384   1.000 24.58897  ? 44   HIS   A CD2  1 
ATOM   116  C  CE1  . HIS   A 1 39  ? 2.27113   -31.06738 4.98568   1.000 28.16925  ? 44   HIS   A CE1  1 
ATOM   117  N  NE2  . HIS   A 1 39  ? 2.43620   -30.00845 5.75976   1.000 27.45709  ? 44   HIS   A NE2  1 
ATOM   118  N  N    . THR   A 1 40  ? 6.05636   -30.47546 0.33086   1.000 28.39625  ? 45   THR   A N    1 
ATOM   119  C  CA   . THR   A 1 40  ? 6.62242   -30.36043 -1.01311  1.000 37.97989  ? 45   THR   A CA   1 
ATOM   120  C  C    . THR   A 1 40  ? 5.61751   -29.83326 -2.04111  1.000 32.88448  ? 45   THR   A C    1 
ATOM   121  O  O    . THR   A 1 40  ? 5.91656   -29.82622 -3.24510  1.000 30.14205  ? 45   THR   A O    1 
ATOM   122  C  CB   . THR   A 1 40  ? 7.18331   -31.71145 -1.46617  1.000 33.79100  ? 45   THR   A CB   1 
ATOM   123  O  OG1  . THR   A 1 40  ? 6.13821   -32.69335 -1.44527  1.000 32.32784  ? 45   THR   A OG1  1 
ATOM   124  C  CG2  . THR   A 1 40  ? 8.32923   -32.16262 -0.53815  1.000 34.84598  ? 45   THR   A CG2  1 
ATOM   125  N  N    . LYS   A 1 41  ? 4.42954   -29.41418 -1.59213  1.000 32.28434  ? 46   LYS   A N    1 
ATOM   126  C  CA   . LYS   A 1 41  ? 3.42963   -28.75503 -2.42313  1.000 32.71819  ? 46   LYS   A CA   1 
ATOM   127  C  C    . LYS   A 1 41  ? 2.74770   -27.68501 -1.57809  1.000 30.82526  ? 46   LYS   A C    1 
ATOM   128  O  O    . LYS   A 1 41  ? 3.07868   -27.49512 -0.40206  1.000 28.35797  ? 46   LYS   A O    1 
ATOM   129  C  CB   . LYS   A 1 41  ? 2.42456   -29.76789 -2.99223  1.000 34.15955  ? 46   LYS   A CB   1 
ATOM   130  C  CG   . LYS   A 1 41  ? 3.08248   -30.88791 -3.80627  1.000 36.13742  ? 46   LYS   A CG   1 
ATOM   131  C  CD   . LYS   A 1 41  ? 2.08344   -31.65975 -4.67336  1.000 40.43021  ? 46   LYS   A CD   1 
ATOM   132  C  CE   . LYS   A 1 41  ? 1.58256   -30.79463 -5.83033  1.000 49.57191  ? 46   LYS   A CE   1 
ATOM   133  N  NZ   . LYS   A 1 41  ? 2.68265   -30.29268 -6.71925  1.000 52.04259  ? 46   LYS   A NZ   1 
ATOM   134  N  N    . ALA   A 1 42  ? 1.81580   -26.95588 -2.19707  1.000 27.42655  ? 47   ALA   A N    1 
ATOM   135  C  CA   . ALA   A 1 42  ? 1.00087   -25.97385 -1.48404  1.000 28.30533  ? 47   ALA   A CA   1 
ATOM   136  C  C    . ALA   A 1 42  ? 0.58276   -26.49090 -0.11209  1.000 27.51267  ? 47   ALA   A C    1 
ATOM   137  O  O    . ALA   A 1 42  ? 0.17665   -27.65287 0.04082   1.000 27.82945  ? 47   ALA   A O    1 
ATOM   138  C  CB   . ALA   A 1 42  ? -0.25107  -25.64768 -2.30407  1.000 27.26346  ? 47   ALA   A CB   1 
ATOM   139  N  N    . VAL   A 1 43  ? 0.66181   -25.61897 0.88897   1.000 24.15528  ? 48   VAL   A N    1 
ATOM   140  C  CA   . VAL   A 1 43  ? 0.07773   -25.90599 2.19693   1.000 26.08755  ? 48   VAL   A CA   1 
ATOM   141  C  C    . VAL   A 1 43  ? -1.34921  -25.36086 2.23091   1.000 27.18526  ? 48   VAL   A C    1 
ATOM   142  O  O    . VAL   A 1 43  ? -1.57109  -24.15582 2.06297   1.000 30.82958  ? 48   VAL   A O    1 
ATOM   143  C  CB   . VAL   A 1 43  ? 0.93075   -25.30915 3.32400   1.000 27.04202  ? 48   VAL   A CB   1 
ATOM   144  C  CG1  . VAL   A 1 43  ? 0.38665   -25.77118 4.67595   1.000 22.57884  ? 48   VAL   A CG1  1 
ATOM   145  C  CG2  . VAL   A 1 43  ? 2.39571   -25.73228 3.13502   1.000 30.22873  ? 48   VAL   A CG2  1 
ATOM   146  N  N    . SER   A 1 44  ? -2.31331  -26.24678 2.45681   1.000 27.73725  ? 49   SER   A N    1 
ATOM   147  C  CA   . SER   A 1 44  ? -3.71527  -25.86763 2.38178   1.000 27.17758  ? 49   SER   A CA   1 
ATOM   148  C  C    . SER   A 1 44  ? -4.28327  -25.36966 3.69779   1.000 25.06347  ? 49   SER   A C    1 
ATOM   149  O  O    . SER   A 1 44  ? -5.13418  -24.47558 3.68682   1.000 25.39476  ? 49   SER   A O    1 
ATOM   150  C  CB   . SER   A 1 44  ? -4.55237  -27.05952 1.90068   1.000 28.38448  ? 49   SER   A CB   1 
ATOM   151  O  OG   . SER   A 1 44  ? -4.31651  -28.20860 2.72361   1.000 28.71605  ? 49   SER   A OG   1 
ATOM   152  N  N    . SER   A 1 45  ? -3.85037  -25.88878 4.84578   1.000 26.24881  ? 50   SER   A N    1 
ATOM   153  C  CA   . SER   A 1 45  ? -4.54338  -25.54479 6.08077   1.000 28.27309  ? 50   SER   A CA   1 
ATOM   154  C  C    . SER   A 1 45  ? -3.60544  -25.74195 7.26880   1.000 30.49274  ? 50   SER   A C    1 
ATOM   155  O  O    . SER   A 1 45  ? -2.91855  -26.76303 7.35976   1.000 29.80693  ? 50   SER   A O    1 
ATOM   156  C  CB   . SER   A 1 45  ? -5.83047  -26.39267 6.20767   1.000 24.43914  ? 50   SER   A CB   1 
ATOM   157  O  OG   . SER   A 1 45  ? -6.70246  -25.88765 7.21167   1.000 26.55593  ? 50   SER   A OG   1 
ATOM   158  N  N    . VAL   A 1 46  ? -3.56438  -24.75701 8.16086   1.000 27.54101  ? 51   VAL   A N    1 
ATOM   159  C  CA   . VAL   A 1 46  ? -2.83644  -24.85716 9.42088   1.000 25.45217  ? 51   VAL   A CA   1 
ATOM   160  C  C    . VAL   A 1 46  ? -3.82546  -24.63214 10.55886  1.000 32.36562  ? 51   VAL   A C    1 
ATOM   161  O  O    . VAL   A 1 46  ? -4.68837  -23.74605 10.48988  1.000 30.70049  ? 51   VAL   A O    1 
ATOM   162  C  CB   . VAL   A 1 46  ? -1.65434  -23.86228 9.49499   1.000 28.42330  ? 51   VAL   A CB   1 
ATOM   163  C  CG1  . VAL   A 1 46  ? -0.55635  -24.27033 8.52800   1.000 24.95825  ? 51   VAL   A CG1  1 
ATOM   164  C  CG2  . VAL   A 1 46  ? -2.10419  -22.41722 9.20806   1.000 23.27255  ? 51   VAL   A CG2  1 
ATOM   165  N  N    . LYS   A 1 47  ? -3.70658  -25.45022 11.60381  1.000 27.88846  ? 52   LYS   A N    1 
ATOM   166  C  CA   . LYS   A 1 47  ? -4.62662  -25.42620 12.73378  1.000 30.89003  ? 52   LYS   A CA   1 
ATOM   167  C  C    . LYS   A 1 47  ? -3.84569  -25.66135 14.02179  1.000 32.43350  ? 52   LYS   A C    1 
ATOM   168  O  O    . LYS   A 1 47  ? -3.05179  -26.60244 14.09776  1.000 32.50799  ? 52   LYS   A O    1 
ATOM   169  C  CB   . LYS   A 1 47  ? -5.72472  -26.50408 12.57967  1.000 26.69201  ? 52   LYS   A CB   1 
ATOM   170  C  CG   . LYS   A 1 47  ? -6.59966  -26.39292 11.32164  1.000 26.72563  ? 52   LYS   A CG   1 
ATOM   171  C  CD   . LYS   A 1 47  ? -7.61156  -25.26583 11.43667  1.000 26.06724  ? 52   LYS   A CD   1 
ATOM   172  C  CE   . LYS   A 1 47  ? -8.42349  -25.09967 10.14465  1.000 26.05388  ? 52   LYS   A CE   1 
ATOM   173  N  NZ   . LYS   A 1 47  ? -9.40159  -26.23656 9.97954   1.000 27.14994  ? 52   LYS   A NZ   1 
ATOM   174  N  N    . PHE   A 1 48  ? -4.06165  -24.81640 15.02884  1.000 31.03393  ? 53   PHE   A N    1 
ATOM   175  C  CA   . PHE   A 1 48  ? -3.48672  -25.06054 16.35384  1.000 30.72185  ? 53   PHE   A CA   1 
ATOM   176  C  C    . PHE   A 1 48  ? -4.33785  -26.05850 17.13275  1.000 33.83144  ? 53   PHE   A C    1 
ATOM   177  O  O    . PHE   A 1 48  ? -5.56884  -26.00838 17.09770  1.000 30.15034  ? 53   PHE   A O    1 
ATOM   178  C  CB   . PHE   A 1 48  ? -3.38263  -23.75960 17.15393  1.000 27.50960  ? 53   PHE   A CB   1 
ATOM   179  C  CG   . PHE   A 1 48  ? -2.31852  -22.82667 16.66103  1.000 30.43189  ? 53   PHE   A CG   1 
ATOM   180  C  CD1  . PHE   A 1 48  ? -0.97955  -23.07881 16.92206  1.000 28.95243  ? 53   PHE   A CD1  1 
ATOM   181  C  CD2  . PHE   A 1 48  ? -2.64638  -21.69159 15.95909  1.000 29.08950  ? 53   PHE   A CD2  1 
ATOM   182  C  CE1  . PHE   A 1 48  ? 0.00155   -22.22088 16.47315  1.000 27.99968  ? 53   PHE   A CE1  1 
ATOM   183  C  CE2  . PHE   A 1 48  ? -1.65628  -20.82366 15.50518  1.000 31.49874  ? 53   PHE   A CE2  1 
ATOM   184  C  CZ   . PHE   A 1 48  ? -0.33331  -21.09280 15.76121  1.000 26.96704  ? 53   PHE   A CZ   1 
ATOM   185  N  N    . SER   A 1 49  ? -3.68396  -26.97361 17.83772  1.000 32.36909  ? 54   SER   A N    1 
ATOM   186  C  CA   . SER   A 1 49  ? -4.44408  -27.88559 18.66263  1.000 34.31596  ? 54   SER   A CA   1 
ATOM   187  C  C    . SER   A 1 49  ? -5.15305  -27.08659 19.75165  1.000 31.99681  ? 54   SER   A C    1 
ATOM   188  O  O    . SER   A 1 49  ? -4.65296  -26.05166 20.20374  1.000 30.97094  ? 54   SER   A O    1 
ATOM   189  C  CB   . SER   A 1 49  ? -3.54621  -28.95771 19.28260  1.000 32.80416  ? 54   SER   A CB   1 
ATOM   190  O  OG   . SER   A 1 49  ? -2.46518  -28.35986 19.96967  1.000 34.08488  ? 54   SER   A OG   1 
ATOM   191  N  N    . PRO   A 1 50  ? -6.33211  -27.53050 20.17458  1.000 32.73566  ? 55   PRO   A N    1 
ATOM   192  C  CA   . PRO   A 1 50  ? -7.03508  -26.81150 21.25260  1.000 35.62885  ? 55   PRO   A CA   1 
ATOM   193  C  C    . PRO   A 1 50  ? -6.20511  -26.65766 22.53164  1.000 42.77234  ? 55   PRO   A C    1 
ATOM   194  O  O    . PRO   A 1 50  ? -6.38404  -25.67269 23.26669  1.000 34.10835  ? 55   PRO   A O    1 
ATOM   195  C  CB   . PRO   A 1 50  ? -8.28817  -27.67539 21.48250  1.000 38.44728  ? 55   PRO   A CB   1 
ATOM   196  C  CG   . PRO   A 1 50  ? -8.48719  -28.40129 20.17244  1.000 37.66381  ? 55   PRO   A CG   1 
ATOM   197  C  CD   . PRO   A 1 50  ? -7.11819  -28.64339 19.60748  1.000 33.55670  ? 55   PRO   A CD   1 
ATOM   198  N  N    . ASN   A 1 51  ? -5.29921  -27.59577 22.82661  1.000 37.59550  ? 56   ASN   A N    1 
ATOM   199  C  CA   . ASN   A 1 51  ? -4.49025  -27.45792 24.03265  1.000 40.66096  ? 56   ASN   A CA   1 
ATOM   200  C  C    . ASN   A 1 51  ? -3.28115  -26.55803 23.82476  1.000 38.62543  ? 56   ASN   A C    1 
ATOM   201  O  O    . ASN   A 1 51  ? -2.46817  -26.40816 24.74780  1.000 37.57847  ? 56   ASN   A O    1 
ATOM   202  C  CB   . ASN   A 1 51  ? -4.05340  -28.83800 24.54958  1.000 35.39287  ? 56   ASN   A CB   1 
ATOM   203  C  CG   . ASN   A 1 51  ? -3.10243  -29.54703 23.60658  1.000 37.77211  ? 56   ASN   A CG   1 
ATOM   204  O  OD1  . ASN   A 1 51  ? -2.52634  -28.93403 22.70464  1.000 38.91700  ? 56   ASN   A OD1  1 
ATOM   205  N  ND2  . ASN   A 1 51  ? -2.93457  -30.84606 23.80950  1.000 40.01268  ? 56   ASN   A ND2  1 
ATOM   206  N  N    . GLY   A 1 52  ? -3.13905  -25.94797 22.64580  1.000 30.89739  ? 57   GLY   A N    1 
ATOM   207  C  CA   . GLY   A 1 52  ? -2.10894  -24.96505 22.44090  1.000 36.44302  ? 57   GLY   A CA   1 
ATOM   208  C  C    . GLY   A 1 52  ? -0.72999  -25.51617 22.15892  1.000 35.90490  ? 57   GLY   A C    1 
ATOM   209  O  O    . GLY   A 1 52  ? 0.17610   -24.73624 21.84000  1.000 35.52728  ? 57   GLY   A O    1 
ATOM   210  N  N    . GLU   A 1 53  ? -0.54412  -26.82819 22.23184  1.000 34.74929  ? 58   GLU   A N    1 
ATOM   211  C  CA   . GLU   A 1 53  ? 0.79583   -27.39431 22.09986  1.000 34.89372  ? 58   GLU   A CA   1 
ATOM   212  C  C    . GLU   A 1 53  ? 1.23587   -27.58026 20.65086  1.000 39.40296  ? 58   GLU   A C    1 
ATOM   213  O  O    . GLU   A 1 53  ? 2.43889   -27.51036 20.36591  1.000 34.32324  ? 58   GLU   A O    1 
ATOM   214  C  CB   . GLU   A 1 53  ? 0.86767   -28.73837 22.84478  1.000 38.61764  ? 58   GLU   A CB   1 
ATOM   215  C  CG   . GLU   A 1 53  ? 0.91763   -28.59147 24.37079  1.000 45.42054  ? 58   GLU   A CG   1 
ATOM   216  C  CD   . GLU   A 1 53  ? 2.14569   -27.80262 24.83888  1.000 44.39891  ? 58   GLU   A CD   1 
ATOM   217  O  OE1  . GLU   A 1 53  ? 3.27767   -28.14670 24.43391  1.000 56.62976  ? 58   GLU   A OE1  1 
ATOM   218  O  OE2  . GLU   A 1 53  ? 1.97575   -26.82965 25.60094  1.000 51.82500  ? 58   GLU   A OE2  1 
ATOM   219  N  N    . TRP   A 1 54  ? 0.30488   -27.82212 19.72481  1.000 34.25707  ? 59   TRP   A N    1 
ATOM   220  C  CA   . TRP   A 1 54  ? 0.67188   -28.31107 18.40280  1.000 33.30148  ? 59   TRP   A CA   1 
ATOM   221  C  C    . TRP   A 1 54  ? 0.05501   -27.47694 17.28683  1.000 33.28318  ? 59   TRP   A C    1 
ATOM   222  O  O    . TRP   A 1 54  ? -1.01394  -26.86684 17.44482  1.000 31.39421  ? 59   TRP   A O    1 
ATOM   223  C  CB   . TRP   A 1 54  ? 0.24475   -29.78502 18.23469  1.000 36.53729  ? 59   TRP   A CB   1 
ATOM   224  C  CG   . TRP   A 1 54  ? 0.85362   -30.68314 19.27965  1.000 38.30062  ? 59   TRP   A CG   1 
ATOM   225  C  CD1  . TRP   A 1 54  ? 0.19552   -31.33414 20.29659  1.000 40.17207  ? 59   TRP   A CD1  1 
ATOM   226  C  CD2  . TRP   A 1 54  ? 2.24158   -31.01429 19.42169  1.000 36.98545  ? 59   TRP   A CD2  1 
ATOM   227  N  NE1  . TRP   A 1 54  ? 1.09542   -32.05228 21.05458  1.000 43.89202  ? 59   TRP   A NE1  1 
ATOM   228  C  CE2  . TRP   A 1 54  ? 2.35646   -31.86737 20.54164  1.000 48.11844  ? 59   TRP   A CE2  1 
ATOM   229  C  CE3  . TRP   A 1 54  ? 3.40164   -30.67235 18.71175  1.000 41.13357  ? 59   TRP   A CE3  1 
ATOM   230  C  CZ2  . TRP   A 1 54  ? 3.58339   -32.38651 20.96165  1.000 50.26644  ? 59   TRP   A CZ2  1 
ATOM   231  C  CZ3  . TRP   A 1 54  ? 4.62558   -31.18150 19.13077  1.000 44.76508  ? 59   TRP   A CZ3  1 
ATOM   232  C  CH2  . TRP   A 1 54  ? 4.70445   -32.03458 20.24672  1.000 48.74494  ? 59   TRP   A CH2  1 
ATOM   233  N  N    . LEU   A 1 55  ? 0.75105   -27.46793 16.15185  1.000 35.56839  ? 60   LEU   A N    1 
ATOM   234  C  CA   . LEU   A 1 55  ? 0.22615   -26.96280 14.88286  1.000 28.20092  ? 60   LEU   A CA   1 
ATOM   235  C  C    . LEU   A 1 55  ? 0.16007   -28.12574 13.90279  1.000 31.01704  ? 60   LEU   A C    1 
ATOM   236  O  O    . LEU   A 1 55  ? 1.17202   -28.79082 13.65879  1.000 32.73941  ? 60   LEU   A O    1 
ATOM   237  C  CB   . LEU   A 1 55  ? 1.09728   -25.83685 14.30597  1.000 31.50069  ? 60   LEU   A CB   1 
ATOM   238  C  CG   . LEU   A 1 55  ? 0.46540   -25.11271 13.08899  1.000 32.07521  ? 60   LEU   A CG   1 
ATOM   239  C  CD1  . LEU   A 1 55  ? -0.60353  -24.13064 13.56901  1.000 31.24585  ? 60   LEU   A CD1  1 
ATOM   240  C  CD2  . LEU   A 1 55  ? 1.49250   -24.40076 12.24407  1.000 29.27706  ? 60   LEU   A CD2  1 
ATOM   241  N  N    . ALA   A 1 56  ? -1.02393  -28.38659 13.35573  1.000 27.06406  ? 61   ALA   A N    1 
ATOM   242  C  CA   . ALA   A 1 56  ? -1.17199  -29.38251 12.30166  1.000 30.93727  ? 61   ALA   A CA   1 
ATOM   243  C  C    . ALA   A 1 56  ? -1.32787  -28.68241 10.95470  1.000 29.49508  ? 61   ALA   A C    1 
ATOM   244  O  O    . ALA   A 1 56  ? -1.99276  -27.64333 10.85174  1.000 28.92943  ? 61   ALA   A O    1 
ATOM   245  C  CB   . ALA   A 1 56  ? -2.36809  -30.29941 12.58056  1.000 29.65207  ? 61   ALA   A CB   1 
ATOM   246  N  N    . SER   A 1 57  ? -0.69688  -29.24040 9.92969   1.000 28.05803  ? 62   SER   A N    1 
ATOM   247  C  CA   . SER   A 1 57  ? -0.76678  -28.68831 8.58272   1.000 27.26457  ? 62   SER   A CA   1 
ATOM   248  C  C    . SER   A 1 57  ? -1.12685  -29.79521 7.59863   1.000 31.76565  ? 62   SER   A C    1 
ATOM   249  O  O    . SER   A 1 57  ? -0.67597  -30.93627 7.74158   1.000 30.39894  ? 62   SER   A O    1 
ATOM   250  C  CB   . SER   A 1 57  ? 0.55130   -28.02841 8.15881   1.000 28.80584  ? 62   SER   A CB   1 
ATOM   251  O  OG   . SER   A 1 57  ? 1.60221   -28.97851 8.13779   1.000 27.89815  ? 62   SER   A OG   1 
ATOM   252  N  N    . SER   A 1 58  ? -1.94278  -29.44607 6.60063   1.000 27.50639  ? 63   SER   A N    1 
ATOM   253  C  CA   . SER   A 1 58  ? -2.28882  -30.33597 5.50456   1.000 26.17063  ? 63   SER   A CA   1 
ATOM   254  C  C    . SER   A 1 58  ? -1.74971  -29.71794 4.22862   1.000 23.85149  ? 63   SER   A C    1 
ATOM   255  O  O    . SER   A 1 58  ? -1.50159  -28.51196 4.16770   1.000 26.45488  ? 63   SER   A O    1 
ATOM   256  C  CB   . SER   A 1 58  ? -3.81684  -30.56481 5.39748   1.000 27.38234  ? 63   SER   A CB   1 
ATOM   257  O  OG   . SER   A 1 58  ? -4.51771  -29.34373 5.19153   1.000 26.00709  ? 63   SER   A OG   1 
ATOM   258  N  N    . SER   A 1 59  ? -1.56576  -30.54890 3.20557   1.000 29.55266  ? 64   SER   A N    1 
ATOM   259  C  CA   . SER   A 1 59  ? -0.91666  -30.07288 1.99163   1.000 26.97197  ? 64   SER   A CA   1 
ATOM   260  C  C    . SER   A 1 59  ? -1.46569  -30.78875 0.76356   1.000 29.97945  ? 64   SER   A C    1 
ATOM   261  O  O    . SER   A 1 59  ? -2.03780  -31.88670 0.83947   1.000 27.24806  ? 64   SER   A O    1 
ATOM   262  C  CB   . SER   A 1 59  ? 0.60832   -30.25303 2.04967   1.000 28.29697  ? 64   SER   A CB   1 
ATOM   263  O  OG   . SER   A 1 59  ? 1.21139   -29.95901 0.80071   1.000 26.38243  ? 64   SER   A OG   1 
ATOM   264  N  N    . ALA   A 1 60  ? -1.28558  -30.12470 -0.37939  1.000 25.76829  ? 65   ALA   A N    1 
ATOM   265  C  CA   . ALA   A 1 60  ? -1.50159  -30.77860 -1.66344  1.000 28.26990  ? 65   ALA   A CA   1 
ATOM   266  C  C    . ALA   A 1 60  ? -0.58571  -31.99367 -1.82948  1.000 33.31569  ? 65   ALA   A C    1 
ATOM   267  O  O    . ALA   A 1 60  ? -0.85376  -32.86260 -2.67455  1.000 30.33685  ? 65   ALA   A O    1 
ATOM   268  C  CB   . ALA   A 1 60  ? -1.27845  -29.76655 -2.79237  1.000 26.28007  ? 65   ALA   A CB   1 
ATOM   269  N  N    . ASP   A 1 61  ? 0.46525   -32.09183 -1.01445  1.000 26.86303  ? 66   ASP   A N    1 
ATOM   270  C  CA   . ASP   A 1 61  ? 1.37715   -33.22691 -1.11149  1.000 31.86625  ? 66   ASP   A CA   1 
ATOM   271  C  C    . ASP   A 1 61  ? 0.81800   -34.46890 -0.44559  1.000 31.02227  ? 66   ASP   A C    1 
ATOM   272  O  O    . ASP   A 1 61  ? 1.55190   -35.43798 -0.27662  1.000 30.62947  ? 66   ASP   A O    1 
ATOM   273  C  CB   . ASP   A 1 61  ? 2.75816   -32.87408 -0.52741  1.000 29.91320  ? 66   ASP   A CB   1 
ATOM   274  C  CG   . ASP   A 1 61  ? 2.75511   -32.75018 0.99360   1.000 30.88676  ? 66   ASP   A CG   1 
ATOM   275  O  OD1  . ASP   A 1 61  ? 1.75905   -33.13712 1.65153   1.000 32.42329  ? 66   ASP   A OD1  1 
ATOM   276  O  OD2  . ASP   A 1 61  ? 3.76714   -32.26531 1.54267   1.000 30.17514  ? 66   ASP   A OD2  1 
ATOM   277  N  N    . LYS   A 1 62  ? -0.45701  -34.45380 -0.06363  1.000 30.26950  ? 67   LYS   A N    1 
ATOM   278  C  CA   . LYS   A 1 62  ? -1.17014  -35.59076 0.49127   1.000 32.70007  ? 67   LYS   A CA   1 
ATOM   279  C  C    . LYS   A 1 62  ? -0.80623  -35.87289 1.94426   1.000 32.84638  ? 67   LYS   A C    1 
ATOM   280  O  O    . LYS   A 1 62  ? -1.23535  -36.91388 2.48618   1.000 29.75867  ? 67   LYS   A O    1 
ATOM   281  C  CB   . LYS   A 1 62  ? -0.91924  -36.86374 -0.32180  1.000 32.48171  ? 67   LYS   A CB   1 
ATOM   282  C  CG   . LYS   A 1 62  ? -1.08616  -36.69163 -1.80280  1.000 32.18394  ? 67   LYS   A CG   1 
ATOM   283  C  CD   . LYS   A 1 62  ? -0.85326  -38.00160 -2.52987  1.000 36.01968  ? 67   LYS   A CD   1 
ATOM   284  C  CE   . LYS   A 1 62  ? -0.56118  -37.74054 -3.99284  1.000 43.74610  ? 67   LYS   A CE   1 
ATOM   285  N  NZ   . LYS   A 1 62  ? -1.19125  -38.76742 -4.87393  1.000 48.02867  ? 67   LYS   A NZ   1 
ATOM   286  N  N    . LEU   A 1 63  ? -0.02517  -35.01001 2.58835   1.000 31.39371  ? 68   LEU   A N    1 
ATOM   287  C  CA   . LEU   A 1 63  ? 0.49676   -35.28814 3.91635   1.000 32.33304  ? 68   LEU   A CA   1 
ATOM   288  C  C    . LEU   A 1 63  ? -0.07719  -34.32815 4.94039   1.000 32.37677  ? 68   LEU   A C    1 
ATOM   289  O  O    . LEU   A 1 63  ? -0.39707  -33.17810 4.63645   1.000 30.07605  ? 68   LEU   A O    1 
ATOM   290  C  CB   . LEU   A 1 63  ? 2.02276   -35.18129 3.95942   1.000 33.15997  ? 68   LEU   A CB   1 
ATOM   291  C  CG   . LEU   A 1 63  ? 2.78472   -36.06030 2.97639   1.000 33.66253  ? 68   LEU   A CG   1 
ATOM   292  C  CD1  . LEU   A 1 63  ? 4.28773   -35.87146 3.20646   1.000 35.50088  ? 68   LEU   A CD1  1 
ATOM   293  C  CD2  . LEU   A 1 63  ? 2.38157   -37.52728 3.15828   1.000 32.70217  ? 68   LEU   A CD2  1 
ATOM   294  N  N    . ILE   A 1 64  ? -0.18628  -34.81422 6.16636   1.000 29.66497  ? 69   ILE   A N    1 
ATOM   295  C  CA   . ILE   A 1 64  ? -0.42525  -33.98827 7.33340   1.000 27.42096  ? 69   ILE   A CA   1 
ATOM   296  C  C    . ILE   A 1 64  ? 0.87673   -33.95544 8.11145   1.000 31.06357  ? 69   ILE   A C    1 
ATOM   297  O  O    . ILE   A 1 64  ? 1.55062   -34.98451 8.23141   1.000 33.02275  ? 69   ILE   A O    1 
ATOM   298  C  CB   . ILE   A 1 64  ? -1.56434  -34.56521 8.19932   1.000 28.55730  ? 69   ILE   A CB   1 
ATOM   299  C  CG1  . ILE   A 1 64  ? -2.88630  -34.51403 7.42527   1.000 29.20982  ? 69   ILE   A CG1  1 
ATOM   300  C  CG2  . ILE   A 1 64  ? -1.63532  -33.82729 9.55836   1.000 26.75079  ? 69   ILE   A CG2  1 
ATOM   301  C  CD1  . ILE   A 1 64  ? -3.99341  -35.34296 8.04018   1.000 31.73076  ? 69   ILE   A CD1  1 
ATOM   302  N  N    . LYS   A 1 65  ? 1.23582   -32.78751 8.63354   1.000 27.18371  ? 70   LYS   A N    1 
ATOM   303  C  CA   . LYS   A 1 65  ? 2.41180   -32.67768 9.48859   1.000 30.46330  ? 70   LYS   A CA   1 
ATOM   304  C  C    . LYS   A 1 65  ? 2.05082   -31.98672 10.79162  1.000 37.76555  ? 70   LYS   A C    1 
ATOM   305  O  O    . LYS   A 1 65  ? 1.18790   -31.09864 10.82864  1.000 33.38404  ? 70   LYS   A O    1 
ATOM   306  C  CB   . LYS   A 1 65  ? 3.54090   -31.92974 8.80168   1.000 28.39338  ? 70   LYS   A CB   1 
ATOM   307  C  CG   . LYS   A 1 65  ? 4.05887   -32.65172 7.56765   1.000 29.69530  ? 70   LYS   A CG   1 
ATOM   308  C  CD   . LYS   A 1 65  ? 5.25097   -31.91879 6.96874   1.000 28.32169  ? 70   LYS   A CD   1 
ATOM   309  C  CE   . LYS   A 1 65  ? 5.85794   -32.69078 5.78572   1.000 31.80701  ? 70   LYS   A CE   1 
ATOM   310  N  NZ   . LYS   A 1 65  ? 6.67581   -33.85989 6.22568   1.000 30.46595  ? 70   LYS   A NZ   1 
ATOM   311  N  N    . ILE   A 1 66  ? 2.72073   -32.41686 11.86262  1.000 32.08601  ? 71   ILE   A N    1 
ATOM   312  C  CA   . ILE   A 1 66  ? 2.52774   -31.87592 13.19564  1.000 33.70252  ? 71   ILE   A CA   1 
ATOM   313  C  C    . ILE   A 1 66  ? 3.79979   -31.13807 13.58574  1.000 32.62264  ? 71   ILE   A C    1 
ATOM   314  O  O    . ILE   A 1 66  ? 4.90275   -31.66617 13.41875  1.000 34.13440  ? 71   ILE   A O    1 
ATOM   315  C  CB   . ILE   A 1 66  ? 2.20459   -32.98495 14.21356  1.000 36.83383  ? 71   ILE   A CB   1 
ATOM   316  C  CG1  . ILE   A 1 66  ? 1.04152   -33.85181 13.72946  1.000 33.00052  ? 71   ILE   A CG1  1 
ATOM   317  C  CG2  . ILE   A 1 66  ? 1.93160   -32.37701 15.59059  1.000 35.10076  ? 71   ILE   A CG2  1 
ATOM   318  C  CD1  . ILE   A 1 66  ? -0.25140  -33.09167 13.52446  1.000 32.98585  ? 71   ILE   A CD1  1 
ATOM   319  N  N    . TRP   A 1 67  ? 3.64589   -29.92509 14.09781  1.000 32.81413  ? 72   TRP   A N    1 
ATOM   320  C  CA   . TRP   A 1 67  ? 4.77796   -29.10522 14.49690  1.000 32.10912  ? 72   TRP   A CA   1 
ATOM   321  C  C    . TRP   A 1 67  ? 4.54995   -28.59329 15.90793  1.000 32.73330  ? 72   TRP   A C    1 
ATOM   322  O  O    . TRP   A 1 67  ? 3.41094   -28.49021 16.38289  1.000 35.28127  ? 72   TRP   A O    1 
ATOM   323  C  CB   . TRP   A 1 67  ? 4.98411   -27.91918 13.55598  1.000 30.59502  ? 72   TRP   A CB   1 
ATOM   324  C  CG   . TRP   A 1 67  ? 4.74313   -28.23207 12.09996  1.000 31.50097  ? 72   TRP   A CG   1 
ATOM   325  C  CD1  . TRP   A 1 67  ? 3.53113   -28.46391 11.50190  1.000 30.66372  ? 72   TRP   A CD1  1 
ATOM   326  C  CD2  . TRP   A 1 67  ? 5.72716   -28.32010 11.05699  1.000 32.90793  ? 72   TRP   A CD2  1 
ATOM   327  N  NE1  . TRP   A 1 67  ? 3.70516   -28.69584 10.15189  1.000 31.19032  ? 72   TRP   A NE1  1 
ATOM   328  C  CE2  . TRP   A 1 67  ? 5.04018   -28.61596 9.85394   1.000 30.83724  ? 72   TRP   A CE2  1 
ATOM   329  C  CE3  . TRP   A 1 67  ? 7.12218   -28.18623 11.02005  1.000 32.11398  ? 72   TRP   A CE3  1 
ATOM   330  C  CZ2  . TRP   A 1 67  ? 5.69821   -28.76394 8.63496   1.000 32.02596  ? 72   TRP   A CZ2  1 
ATOM   331  C  CZ3  . TRP   A 1 67  ? 7.77721   -28.34122 9.80306   1.000 30.95517  ? 72   TRP   A CZ3  1 
ATOM   332  C  CH2  . TRP   A 1 67  ? 7.06423   -28.62208 8.62602   1.000 31.34751  ? 72   TRP   A CH2  1 
ATOM   333  N  N    . GLY   A 1 68  ? 5.65096   -28.24944 16.57099  1.000 35.06873  ? 73   GLY   A N    1 
ATOM   334  C  CA   . GLY   A 1 68  ? 5.56697   -27.64051 17.89002  1.000 35.26789  ? 73   GLY   A CA   1 
ATOM   335  C  C    . GLY   A 1 68  ? 5.13411   -26.19046 17.77510  1.000 31.64703  ? 73   GLY   A C    1 
ATOM   336  O  O    . GLY   A 1 68  ? 5.74822   -25.40448 17.04317  1.000 30.98695  ? 73   GLY   A O    1 
ATOM   337  N  N    . ALA   A 1 69  ? 4.06212   -25.83440 18.49408  1.000 33.14564  ? 74   ALA   A N    1 
ATOM   338  C  CA   . ALA   A 1 69  ? 3.45626   -24.51533 18.29414  1.000 29.73948  ? 74   ALA   A CA   1 
ATOM   339  C  C    . ALA   A 1 69  ? 4.35035   -23.38745 18.79625  1.000 38.68529  ? 74   ALA   A C    1 
ATOM   340  O  O    . ALA   A 1 69  ? 4.33148   -22.28941 18.22731  1.000 38.19897  ? 74   ALA   A O    1 
ATOM   341  C  CB   . ALA   A 1 69  ? 2.08324   -24.44324 18.97509  1.000 31.61488  ? 74   ALA   A CB   1 
ATOM   342  N  N    . TYR   A 1 70  ? 5.15828   -23.64259 19.83526  1.000 35.00557  ? 75   TYR   A N    1 
ATOM   343  C  CA   . TYR   A 1 70  ? 5.98436   -22.59171 20.40936  1.000 37.32022  ? 75   TYR   A CA   1 
ATOM   344  C  C    . TYR   A 1 70  ? 7.39439   -22.54981 19.84041  1.000 35.89814  ? 75   TYR   A C    1 
ATOM   345  O  O    . TYR   A 1 70  ? 8.01849   -21.48687 19.84850  1.000 44.33328  ? 75   TYR   A O    1 
ATOM   346  C  CB   . TYR   A 1 70  ? 6.03529   -22.75581 21.92935  1.000 34.58264  ? 75   TYR   A CB   1 
ATOM   347  C  CG   . TYR   A 1 70  ? 4.66626   -22.80772 22.53829  1.000 33.38874  ? 75   TYR   A CG   1 
ATOM   348  C  CD1  . TYR   A 1 70  ? 3.88037   -21.66165 22.60934  1.000 38.09926  ? 75   TYR   A CD1  1 
ATOM   349  C  CD2  . TYR   A 1 70  ? 4.14513   -23.99570 23.03120  1.000 33.61399  ? 75   TYR   A CD2  1 
ATOM   350  C  CE1  . TYR   A 1 70  ? 2.60935   -21.69556 23.16829  1.000 36.47441  ? 75   TYR   A CE1  1 
ATOM   351  C  CE2  . TYR   A 1 70  ? 2.86710   -24.04561 23.58515  1.000 37.12115  ? 75   TYR   A CE2  1 
ATOM   352  C  CZ   . TYR   A 1 70  ? 2.10421   -22.88454 23.65619  1.000 37.95208  ? 75   TYR   A CZ   1 
ATOM   353  O  OH   . TYR   A 1 70  ? 0.83219   -22.91045 24.21314  1.000 42.38464  ? 75   TYR   A OH   1 
ATOM   354  N  N    . ASP   A 1 71  ? 7.91830   -23.66883 19.34236  1.000 34.14279  ? 76   ASP   A N    1 
ATOM   355  C  CA   . ASP   A 1 71  ? 9.25532   -23.70193 18.76141  1.000 33.49306  ? 76   ASP   A CA   1 
ATOM   356  C  C    . ASP   A 1 71  ? 9.26535   -23.97283 17.26640  1.000 37.53195  ? 76   ASP   A C    1 
ATOM   357  O  O    . ASP   A 1 71  ? 10.33438  -23.90790 16.64944  1.000 35.74999  ? 76   ASP   A O    1 
ATOM   358  C  CB   . ASP   A 1 71  ? 10.11419  -24.76905 19.46638  1.000 37.92546  ? 76   ASP   A CB   1 
ATOM   359  C  CG   . ASP   A 1 71  ? 9.49105   -26.16199 19.42127  1.000 43.64418  ? 76   ASP   A CG   1 
ATOM   360  O  OD1  . ASP   A 1 71  ? 8.53306   -26.38185 18.64222  1.000 43.13992  ? 76   ASP   A OD1  1 
ATOM   361  O  OD2  . ASP   A 1 71  ? 9.95894   -27.04908 20.17323  1.000 44.22005  ? 76   ASP   A OD2  1 
ATOM   362  N  N    . GLY   A 1 72  ? 8.12134   -24.29368 16.66933  1.000 37.35979  ? 77   GLY   A N    1 
ATOM   363  C  CA   . GLY   A 1 72  ? 8.10636   -24.60259 15.25331  1.000 39.56031  ? 77   GLY   A CA   1 
ATOM   364  C  C    . GLY   A 1 72  ? 8.80525   -25.88464 14.85926  1.000 43.13250  ? 77   GLY   A C    1 
ATOM   365  O  O    . GLY   A 1 72  ? 9.03928   -26.10358 13.66625  1.000 39.25016  ? 77   GLY   A O    1 
ATOM   366  N  N    . LYS   A 1 73  ? 9.13313   -26.74473 15.81722  1.000 40.85671  ? 78   LYS   A N    1 
ATOM   367  C  CA   . LYS   A 1 73  ? 9.91903   -27.94079 15.54417  1.000 41.01503  ? 78   LYS   A CA   1 
ATOM   368  C  C    . LYS   A 1 73  ? 9.03295   -29.01666 14.93607  1.000 35.30357  ? 78   LYS   A C    1 
ATOM   369  O  O    . LYS   A 1 73  ? 7.97390   -29.33260 15.48801  1.000 35.97659  ? 78   LYS   A O    1 
ATOM   370  C  CB   . LYS   A 1 73  ? 10.54493  -28.44093 16.84916  1.000 44.55335  ? 78   LYS   A CB   1 
ATOM   371  C  CG   . LYS   A 1 73  ? 11.33881  -29.74400 16.77611  1.000 47.87438  ? 78   LYS   A CG   1 
ATOM   372  C  CD   . LYS   A 1 73  ? 11.97572  -30.04615 18.15812  1.000 43.93596  ? 78   LYS   A CD   1 
ATOM   373  C  CE   . LYS   A 1 73  ? 12.91061  -31.25624 18.12308  1.000 56.05055  ? 78   LYS   A CE   1 
ATOM   374  N  NZ   . LYS   A 1 73  ? 12.19647  -32.56619 18.34497  1.000 62.57673  ? 78   LYS   A NZ   1 
ATOM   375  N  N    . PHE   A 1 74  ? 9.46194   -29.57563 13.80305  1.000 33.50157  ? 79   PHE   A N    1 
ATOM   376  C  CA   . PHE   A 1 74  ? 8.75685   -30.71253 13.21395  1.000 33.93884  ? 79   PHE   A CA   1 
ATOM   377  C  C    . PHE   A 1 74  ? 8.62670   -31.85958 14.21888  1.000 39.24163  ? 79   PHE   A C    1 
ATOM   378  O  O    . PHE   A 1 74  ? 9.54464   -32.15572 14.98689  1.000 44.00163  ? 79   PHE   A O    1 
ATOM   379  C  CB   . PHE   A 1 74  ? 9.46585   -31.19852 11.93595  1.000 33.68765  ? 79   PHE   A CB   1 
ATOM   380  C  CG   . PHE   A 1 74  ? 8.85775   -32.46742 11.33085  1.000 37.66539  ? 79   PHE   A CG   1 
ATOM   381  C  CD1  . PHE   A 1 74  ? 7.69378   -32.41226 10.56381  1.000 37.91649  ? 79   PHE   A CD1  1 
ATOM   382  C  CD2  . PHE   A 1 74  ? 9.45062   -33.71149 11.53079  1.000 40.78643  ? 79   PHE   A CD2  1 
ATOM   383  C  CE1  . PHE   A 1 74  ? 7.13269   -33.57617 10.01471  1.000 38.06093  ? 79   PHE   A CE1  1 
ATOM   384  C  CE2  . PHE   A 1 74  ? 8.89153   -34.87140 10.98170  1.000 42.06390  ? 79   PHE   A CE2  1 
ATOM   385  C  CZ   . PHE   A 1 74  ? 7.73256   -34.79924 10.22366  1.000 39.30592  ? 79   PHE   A CZ   1 
ATOM   386  N  N    . GLU   A 1 75  ? 7.46364   -32.50147 14.22179  1.000 34.68459  ? 80   GLU   A N    1 
ATOM   387  C  CA   . GLU   A 1 75  ? 7.19949   -33.61750 15.12371  1.000 40.25402  ? 80   GLU   A CA   1 
ATOM   388  C  C    . GLU   A 1 75  ? 6.97940   -34.91043 14.35362  1.000 41.45338  ? 80   GLU   A C    1 
ATOM   389  O  O    . GLU   A 1 75  ? 7.67529   -35.89751 14.61259  1.000 42.42002  ? 80   GLU   A O    1 
ATOM   390  C  CB   . GLU   A 1 75  ? 5.99649   -33.29244 16.01669  1.000 37.36324  ? 80   GLU   A CB   1 
ATOM   391  C  CG   . GLU   A 1 75  ? 5.32335   -34.50141 16.65758  1.000 47.11216  ? 80   GLU   A CG   1 
ATOM   392  C  CD   . GLU   A 1 75  ? 5.93426   -34.88055 17.99958  1.000 56.64351  ? 80   GLU   A CD   1 
ATOM   393  O  OE1  . GLU   A 1 75  ? 7.11029   -34.51169 18.25965  1.000 52.20374  ? 80   GLU   A OE1  1 
ATOM   394  O  OE2  . GLU   A 1 75  ? 5.22617   -35.54354 18.79551  1.000 60.29646  ? 80   GLU   A OE2  1 
ATOM   395  N  N    . LYS   A 1 76  ? 6.03843   -34.94828 13.41158  1.000 38.56518  ? 81   LYS   A N    1 
ATOM   396  C  CA   . LYS   A 1 76  ? 5.77234   -36.18721 12.70250  1.000 33.95990  ? 81   LYS   A CA   1 
ATOM   397  C  C    . LYS   A 1 76  ? 4.97641   -35.87705 11.45248  1.000 38.47518  ? 81   LYS   A C    1 
ATOM   398  O  O    . LYS   A 1 76  ? 4.35452   -34.81298 11.32853  1.000 35.11813  ? 81   LYS   A O    1 
ATOM   399  C  CB   . LYS   A 1 76  ? 5.01220   -37.18819 13.57740  1.000 32.82462  ? 81   LYS   A CB   1 
ATOM   400  C  CG   . LYS   A 1 76  ? 3.55723   -36.81706 13.79037  1.000 36.74939  ? 81   LYS   A CG   1 
ATOM   401  C  CD   . LYS   A 1 76  ? 2.75810   -37.94702 14.44627  1.000 39.36184  ? 81   LYS   A CD   1 
ATOM   402  C  CE   . LYS   A 1 76  ? 3.15303   -38.12215 15.90427  1.000 40.81993  ? 81   LYS   A CE   1 
ATOM   403  N  NZ   . LYS   A 1 76  ? 2.43289   -39.28212 16.50617  1.000 42.57880  ? 81   LYS   A NZ   1 
ATOM   404  N  N    . THR   A 1 77  ? 5.00935   -36.83200 10.53143  1.000 34.93822  ? 82   THR   A N    1 
ATOM   405  C  CA   . THR   A 1 77  ? 4.21140   -36.81884 9.32040   1.000 35.65958  ? 82   THR   A CA   1 
ATOM   406  C  C    . THR   A 1 77  ? 3.14629   -37.89874 9.42029   1.000 39.46012  ? 82   THR   A C    1 
ATOM   407  O  O    . THR   A 1 77  ? 3.39817   -38.99180 9.94323   1.000 36.86653  ? 82   THR   A O    1 
ATOM   408  C  CB   . THR   A 1 77  ? 5.07643   -37.06085 8.09041   1.000 31.70324  ? 82   THR   A CB   1 
ATOM   409  O  OG1  . THR   A 1 77  ? 6.07553   -36.03794 7.99652   1.000 32.74959  ? 82   THR   A OG1  1 
ATOM   410  C  CG2  . THR   A 1 77  ? 4.20647   -37.07369 6.84538   1.000 36.53891  ? 82   THR   A CG2  1 
ATOM   411  N  N    . ILE   A 1 78  ? 1.95234   -37.58260 8.93626   1.000 35.19567  ? 83   ILE   A N    1 
ATOM   412  C  CA   . ILE   A 1 78  ? 0.82425   -38.50049 8.95516   1.000 32.34472  ? 83   ILE   A CA   1 
ATOM   413  C  C    . ILE   A 1 78  ? 0.34929   -38.66935 7.52013   1.000 35.47741  ? 83   ILE   A C    1 
ATOM   414  O  O    . ILE   A 1 78  ? 0.08241   -37.68028 6.82519   1.000 36.84572  ? 83   ILE   A O    1 
ATOM   415  C  CB   . ILE   A 1 78  ? -0.29673  -37.99344 9.88115   1.000 34.71702  ? 83   ILE   A CB   1 
ATOM   416  C  CG1  . ILE   A 1 78  ? 0.19421   -38.03358 11.32917  1.000 35.99336  ? 83   ILE   A CG1  1 
ATOM   417  C  CG2  . ILE   A 1 78  ? -1.55981  -38.82531 9.71905   1.000 31.69291  ? 83   ILE   A CG2  1 
ATOM   418  C  CD1  . ILE   A 1 78  ? -0.66576  -37.27156 12.30618  1.000 32.14898  ? 83   ILE   A CD1  1 
ATOM   419  N  N    . SER   A 1 79  ? 0.27019   -39.91432 7.06705   1.000 36.77327  ? 84   SER   A N    1 
ATOM   420  C  CA   . SER   A 1 79  ? 0.05021   -40.17821 5.65503   1.000 38.68401  ? 84   SER   A CA   1 
ATOM   421  C  C    . SER   A 1 79  ? -1.02688  -41.23609 5.48792   1.000 39.59592  ? 84   SER   A C    1 
ATOM   422  O  O    . SER   A 1 79  ? -1.30499  -42.02612 6.39686   1.000 38.80090  ? 84   SER   A O    1 
ATOM   423  C  CB   . SER   A 1 79  ? 1.34520   -40.62629 4.97305   1.000 40.38323  ? 84   SER   A CB   1 
ATOM   424  O  OG   . SER   A 1 79  ? 1.77406   -41.84737 5.54999   1.000 43.99532  ? 84   SER   A OG   1 
ATOM   425  N  N    . GLY   A 1 80  ? -1.61384  -41.25396 4.29590   1.000 37.74234  ? 85   GLY   A N    1 
ATOM   426  C  CA   . GLY   A 1 80  ? -2.68492  -42.17884 3.97680   1.000 36.90420  ? 85   GLY   A CA   1 
ATOM   427  C  C    . GLY   A 1 80  ? -3.62283  -41.70567 2.87579   1.000 36.41419  ? 85   GLY   A C    1 
ATOM   428  O  O    . GLY   A 1 80  ? -4.09688  -42.52458 2.08572   1.000 34.16855  ? 85   GLY   A O    1 
ATOM   429  N  N    . HIS   A 1 81  ? -3.92470  -40.40264 2.81586   1.000 33.94033  ? 86   HIS   A N    1 
ATOM   430  C  CA   . HIS   A 1 81  ? -4.73661  -39.89149 1.71386   1.000 32.69733  ? 86   HIS   A CA   1 
ATOM   431  C  C    . HIS   A 1 81  ? -4.03258  -40.13748 0.38687   1.000 34.62835  ? 86   HIS   A C    1 
ATOM   432  O  O    . HIS   A 1 81  ? -2.80357  -40.09559 0.29192   1.000 33.23329  ? 86   HIS   A O    1 
ATOM   433  C  CB   . HIS   A 1 81  ? -5.03047  -38.39848 1.88595   1.000 26.21264  ? 86   HIS   A CB   1 
ATOM   434  C  CG   . HIS   A 1 81  ? -6.16948  -38.12442 2.81792   1.000 30.08760  ? 86   HIS   A CG   1 
ATOM   435  N  ND1  . HIS   A 1 81  ? -7.44951  -38.58528 2.58384   1.000 31.44984  ? 86   HIS   A ND1  1 
ATOM   436  C  CD2  . HIS   A 1 81  ? -6.22146  -37.45749 3.99496   1.000 30.35700  ? 86   HIS   A CD2  1 
ATOM   437  C  CE1  . HIS   A 1 81  ? -8.24151  -38.20327 3.57484   1.000 31.74108  ? 86   HIS   A CE1  1 
ATOM   438  N  NE2  . HIS   A 1 81  ? -7.52148  -37.51339 4.44191   1.000 31.23443  ? 86   HIS   A NE2  1 
ATOM   439  N  N    . LYS   A 1 82  ? -4.83357  -40.37734 -0.65117  1.000 32.30598  ? 87   LYS   A N    1 
ATOM   440  C  CA   . LYS   A 1 82  ? -4.28555  -40.72731 -1.95017  1.000 36.98978  ? 87   LYS   A CA   1 
ATOM   441  C  C    . LYS   A 1 82  ? -4.10740  -39.52227 -2.85409  1.000 33.71230  ? 87   LYS   A C    1 
ATOM   442  O  O    . LYS   A 1 82  ? -3.38337  -39.62228 -3.84907  1.000 36.47016  ? 87   LYS   A O    1 
ATOM   443  C  CB   . LYS   A 1 82  ? -5.18063  -41.77218 -2.62427  1.000 38.23585  ? 87   LYS   A CB   1 
ATOM   444  C  CG   . LYS   A 1 82  ? -5.31078  -43.07721 -1.82936  1.000 41.62259  ? 87   LYS   A CG   1 
ATOM   445  C  CD   . LYS   A 1 82  ? -6.36885  -44.01307 -2.43346  1.000 55.27704  ? 87   LYS   A CD   1 
ATOM   446  C  CE   . LYS   A 1 82  ? -5.99984  -44.44202 -3.85847  1.000 60.05806  ? 87   LYS   A CE   1 
ATOM   447  N  NZ   . LYS   A 1 82  ? -7.09377  -44.16685 -4.84850  1.000 59.83227  ? 87   LYS   A NZ   1 
ATOM   448  N  N    . LEU   A 1 83  ? -4.73930  -38.39423 -2.52504  1.000 33.96608  ? 88   LEU   A N    1 
ATOM   449  C  CA   . LEU   A 1 83  ? -4.59915  -37.15319 -3.27096  1.000 34.01505  ? 88   LEU   A CA   1 
ATOM   450  C  C    . LEU   A 1 83  ? -4.45708  -36.00227 -2.27088  1.000 32.26503  ? 88   LEU   A C    1 
ATOM   451  O  O    . LEU   A 1 83  ? -4.43514  -36.21435 -1.05789  1.000 33.42554  ? 88   LEU   A O    1 
ATOM   452  C  CB   . LEU   A 1 83  ? -5.79709  -36.92102 -4.21799  1.000 35.17603  ? 88   LEU   A CB   1 
ATOM   453  C  CG   . LEU   A 1 83  ? -6.06214  -37.88592 -5.39106  1.000 39.97284  ? 88   LEU   A CG   1 
ATOM   454  C  CD1  . LEU   A 1 83  ? -7.39709  -37.57275 -6.07509  1.000 36.71216  ? 88   LEU   A CD1  1 
ATOM   455  C  CD2  . LEU   A 1 83  ? -4.91910  -37.85796 -6.41802  1.000 36.68607  ? 88   LEU   A CD2  1 
ATOM   456  N  N    . GLY   A 1 84  ? -4.37994  -34.77524 -2.79880  1.000 30.15717  ? 89   GLY   A N    1 
ATOM   457  C  CA   . GLY   A 1 84  ? -4.23185  -33.57031 -2.00272  1.000 30.35685  ? 89   GLY   A CA   1 
ATOM   458  C  C    . GLY   A 1 84  ? -5.22989  -33.47728 -0.86275  1.000 32.03262  ? 89   GLY   A C    1 
ATOM   459  O  O    . GLY   A 1 84  ? -6.35193  -33.99517 -0.94283  1.000 30.72847  ? 89   GLY   A O    1 
ATOM   460  N  N    . ILE   A 1 85  ? -4.80587  -32.84239 0.22530   1.000 26.25236  ? 90   ILE   A N    1 
ATOM   461  C  CA   . ILE   A 1 85  ? -5.66588  -32.53538 1.35629   1.000 31.00508  ? 90   ILE   A CA   1 
ATOM   462  C  C    . ILE   A 1 85  ? -5.91073  -31.03536 1.35638   1.000 30.67371  ? 90   ILE   A C    1 
ATOM   463  O  O    . ILE   A 1 85  ? -4.95565  -30.25244 1.26946   1.000 29.56158  ? 90   ILE   A O    1 
ATOM   464  C  CB   . ILE   A 1 85  ? -5.01897  -32.98153 2.67429   1.000 27.88425  ? 90   ILE   A CB   1 
ATOM   465  C  CG1  . ILE   A 1 85  ? -4.60711  -34.45056 2.57121   1.000 33.10474  ? 90   ILE   A CG1  1 
ATOM   466  C  CG2  . ILE   A 1 85  ? -5.97999  -32.72151 3.84727   1.000 28.48918  ? 90   ILE   A CG2  1 
ATOM   467  C  CD1  . ILE   A 1 85  ? -3.67420  -34.89372 3.68822   1.000 30.12928  ? 90   ILE   A CD1  1 
ATOM   468  N  N    . SER   A 1 86  ? -7.17770  -30.62024 1.45435   1.000 26.08162  ? 91   SER   A N    1 
ATOM   469  C  CA   . SER   A 1 86  ? -7.40556  -29.18322 1.54043   1.000 30.07021  ? 91   SER   A CA   1 
ATOM   470  C  C    . SER   A 1 86  ? -7.74157  -28.70828 2.95045   1.000 26.61655  ? 91   SER   A C    1 
ATOM   471  O  O    . SER   A 1 86  ? -7.70146  -27.50230 3.19953   1.000 28.70103  ? 91   SER   A O    1 
ATOM   472  C  CB   . SER   A 1 86  ? -8.46848  -28.73205 0.50942   1.000 35.72514  ? 91   SER   A CB   1 
ATOM   473  O  OG   . SER   A 1 86  ? -9.79951  -28.91295 0.88136   1.000 31.94575  ? 91   SER   A OG   1 
ATOM   474  N  N    . ASP   A 1 87  ? -7.97269  -29.60832 3.91239   1.000 27.46691  ? 92   ASP   A N    1 
ATOM   475  C  CA   . ASP   A 1 87  ? -8.30369  -29.09437 5.23041   1.000 23.44964  ? 92   ASP   A CA   1 
ATOM   476  C  C    . ASP   A 1 87  ? -8.04284  -30.15946 6.28035   1.000 27.14956  ? 92   ASP   A C    1 
ATOM   477  O  O    . ASP   A 1 87  ? -8.09894  -31.35744 6.00727   1.000 28.29450  ? 92   ASP   A O    1 
ATOM   478  C  CB   . ASP   A 1 87  ? -9.76665  -28.63023 5.28538   1.000 25.46039  ? 92   ASP   A CB   1 
ATOM   479  C  CG   . ASP   A 1 87  ? -10.05761 -27.72927 6.45943   1.000 26.66603  ? 92   ASP   A CG   1 
ATOM   480  O  OD1  . ASP   A 1 87  ? -9.10057  -27.16241 7.05350   1.000 25.42633  ? 92   ASP   A OD1  1 
ATOM   481  O  OD2  . ASP   A 1 87  ? -11.26160 -27.59118 6.78639   1.000 28.56271  ? 92   ASP   A OD2  1 
ATOM   482  N  N    . VAL   A 1 88  ? -7.78284  -29.69956 7.49639   1.000 28.39214  ? 93   VAL   A N    1 
ATOM   483  C  CA   . VAL   A 1 88  ? -7.57097  -30.58765 8.62634   1.000 31.41297  ? 93   VAL   A CA   1 
ATOM   484  C  C    . VAL   A 1 88  ? -8.11194  -29.87068 9.85636   1.000 29.29418  ? 93   VAL   A C    1 
ATOM   485  O  O    . VAL   A 1 88  ? -8.18182  -28.63567 9.89644   1.000 25.35482  ? 93   VAL   A O    1 
ATOM   486  C  CB   . VAL   A 1 88  ? -6.07501  -30.95981 8.77837   1.000 28.30118  ? 93   VAL   A CB   1 
ATOM   487  C  CG1  . VAL   A 1 88  ? -5.26391  -29.72991 9.22448   1.000 29.22630  ? 93   VAL   A CG1  1 
ATOM   488  C  CG2  . VAL   A 1 88  ? -5.92015  -32.07288 9.76031   1.000 32.57242  ? 93   VAL   A CG2  1 
ATOM   489  N  N    . ALA   A 1 89  ? -8.49906  -30.65370 10.86630  1.000 30.11738  ? 94   ALA   A N    1 
ATOM   490  C  CA   . ALA   A 1 89  ? -9.15105  -30.09071 12.04131  1.000 30.28108  ? 94   ALA   A CA   1 
ATOM   491  C  C    . ALA   A 1 89  ? -8.91618  -30.98781 13.25326  1.000 31.67123  ? 94   ALA   A C    1 
ATOM   492  O  O    . ALA   A 1 89  ? -8.84230  -32.21681 13.13119  1.000 34.37701  ? 94   ALA   A O    1 
ATOM   493  C  CB   . ALA   A 1 89  ? -10.66002 -29.90155 11.79027  1.000 24.20172  ? 94   ALA   A CB   1 
ATOM   494  N  N    . TRP   A 1 90  ? -8.83616  -30.35089 14.42531  1.000 30.07818  ? 95   TRP   A N    1 
ATOM   495  C  CA   . TRP   A 1 90  ? -8.56828  -31.02100 15.69328  1.000 31.71183  ? 95   TRP   A CA   1 
ATOM   496  C  C    . TRP   A 1 90  ? -9.86634  -31.34992 16.41621  1.000 38.18412  ? 95   TRP   A C    1 
ATOM   497  O  O    . TRP   A 1 90  ? -10.82726 -30.57282 16.36922  1.000 34.83710  ? 95   TRP   A O    1 
ATOM   498  C  CB   . TRP   A 1 90  ? -7.73522  -30.12914 16.61636  1.000 29.05980  ? 95   TRP   A CB   1 
ATOM   499  C  CG   . TRP   A 1 90  ? -6.31318  -29.87925 16.19443  1.000 31.85998  ? 95   TRP   A CG   1 
ATOM   500  C  CD1  . TRP   A 1 90  ? -5.84605  -28.82925 15.43952  1.000 30.29056  ? 95   TRP   A CD1  1 
ATOM   501  C  CD2  . TRP   A 1 90  ? -5.16227  -30.67738 16.52143  1.000 33.91552  ? 95   TRP   A CD2  1 
ATOM   502  N  NE1  . TRP   A 1 90  ? -4.47806  -28.93037 15.28156  1.000 30.47106  ? 95   TRP   A NE1  1 
ATOM   503  C  CE2  . TRP   A 1 90  ? -4.03819  -30.05746 15.92751  1.000 31.63336  ? 95   TRP   A CE2  1 
ATOM   504  C  CE3  . TRP   A 1 90  ? -4.97442  -31.85945 17.25336  1.000 31.83620  ? 95   TRP   A CE3  1 
ATOM   505  C  CZ2  . TRP   A 1 90  ? -2.74725  -30.57359 16.04952  1.000 31.46812  ? 95   TRP   A CZ2  1 
ATOM   506  C  CZ3  . TRP   A 1 90  ? -3.68447  -32.36558 17.37838  1.000 31.56620  ? 95   TRP   A CZ3  1 
ATOM   507  C  CH2  . TRP   A 1 90  ? -2.59339  -31.72665 16.76746  1.000 34.42006  ? 95   TRP   A CH2  1 
ATOM   508  N  N    . SER   A 1 91  ? -9.87847  -32.48696 17.10613  1.000 39.17604  ? 96   SER   A N    1 
ATOM   509  C  CA   . SER   A 1 91  ? -10.93253 -32.74192 18.08308  1.000 37.58647  ? 96   SER   A CA   1 
ATOM   510  C  C    . SER   A 1 91  ? -10.69050 -31.91702 19.34914  1.000 36.02645  ? 96   SER   A C    1 
ATOM   511  O  O    . SER   A 1 91  ? -9.58447  -31.44415 19.60821  1.000 36.54546  ? 96   SER   A O    1 
ATOM   512  C  CB   . SER   A 1 91  ? -11.00969 -34.23393 18.43098  1.000 37.62135  ? 96   SER   A CB   1 
ATOM   513  O  OG   . SER   A 1 91  ? -9.78876  -34.68009 19.00200  1.000 37.12367  ? 96   SER   A OG   1 
ATOM   514  N  N    . SER   A 1 92  ? -11.75551 -31.72497 20.13411  1.000 36.72046  ? 97   SER   A N    1 
ATOM   515  C  CA   . SER   A 1 92  ? -11.66447 -30.83805 21.29317  1.000 39.53457  ? 97   SER   A CA   1 
ATOM   516  C  C    . SER   A 1 92  ? -10.57355 -31.26322 22.26718  1.000 34.14933  ? 97   SER   A C    1 
ATOM   517  O  O    . SER   A 1 92  ? -9.95549  -30.41132 22.92426  1.000 36.97654  ? 97   SER   A O    1 
ATOM   518  C  CB   . SER   A 1 92  ? -13.01149 -30.77897 22.02312  1.000 43.09714  ? 97   SER   A CB   1 
ATOM   519  O  OG   . SER   A 1 92  ? -14.06643 -30.46281 21.11910  1.000 48.04612  ? 97   SER   A OG   1 
ATOM   520  N  N    . ASP   A 1 93  ? -10.32868 -32.56425 22.40211  1.000 36.79211  ? 98   ASP   A N    1 
ATOM   521  C  CA   . ASP   A 1 93  ? -9.33576  -33.02741 23.36612  1.000 41.32743  ? 98   ASP   A CA   1 
ATOM   522  C  C    . ASP   A 1 93  ? -7.92575  -33.11451 22.77717  1.000 43.43041  ? 98   ASP   A C    1 
ATOM   523  O  O    . ASP   A 1 93  ? -7.03983  -33.70663 23.40316  1.000 39.41107  ? 98   ASP   A O    1 
ATOM   524  C  CB   . ASP   A 1 93  ? -9.75292  -34.37841 23.97102  1.000 38.11401  ? 98   ASP   A CB   1 
ATOM   525  C  CG   . ASP   A 1 93  ? -9.73899  -35.52834 22.95495  1.000 45.78031  ? 98   ASP   A CG   1 
ATOM   526  O  OD1  . ASP   A 1 93  ? -9.50292  -35.29029 21.74297  1.000 43.91235  ? 98   ASP   A OD1  1 
ATOM   527  O  OD2  . ASP   A 1 93  ? -9.97812  -36.68535 23.37887  1.000 47.05607  ? 98   ASP   A OD2  1 
ATOM   528  N  N    . SER   A 1 94  ? -7.69565  -32.53346 21.59821  1.000 34.90601  ? 99   SER   A N    1 
ATOM   529  C  CA   . SER   A 1 94  ? -6.38762  -32.48654 20.94627  1.000 37.23145  ? 99   SER   A CA   1 
ATOM   530  C  C    . SER   A 1 94  ? -5.82574  -33.86158 20.63420  1.000 36.40791  ? 99   SER   A C    1 
ATOM   531  O  O    . SER   A 1 94  ? -4.63174  -33.97767 20.31824  1.000 37.87652  ? 99   SER   A O    1 
ATOM   532  C  CB   . SER   A 1 94  ? -5.36957  -31.69269 21.77435  1.000 32.68749  ? 99   SER   A CB   1 
ATOM   533  O  OG   . SER   A 1 94  ? -5.82746  -30.38067 22.03842  1.000 34.90133  ? 99   SER   A OG   1 
ATOM   534  N  N    . ASN   A 1 95  ? -6.64684  -34.90550 20.68710  1.000 37.08703  ? 100  ASN   A N    1 
ATOM   535  C  CA   . ASN   A 1 95  ? -6.11096  -36.22053 20.39304  1.000 41.92342  ? 100  ASN   A CA   1 
ATOM   536  C  C    . ASN   A 1 95  ? -6.38595  -36.68342 18.97000  1.000 43.39668  ? 100  ASN   A C    1 
ATOM   537  O  O    . ASN   A 1 95  ? -5.60401  -37.48546 18.44398  1.000 40.05819  ? 100  ASN   A O    1 
ATOM   538  C  CB   . ASN   A 1 95  ? -6.64510  -37.23855 21.40196  1.000 46.34200  ? 100  ASN   A CB   1 
ATOM   539  C  CG   . ASN   A 1 95  ? -5.98813  -37.08370 22.77199  1.000 50.45846  ? 100  ASN   A CG   1 
ATOM   540  O  OD1  . ASN   A 1 95  ? -4.77312  -36.86682 22.86605  1.000 45.23598  ? 100  ASN   A OD1  1 
ATOM   541  N  ND2  . ASN   A 1 95  ? -6.79118  -37.16568 23.83496  1.000 50.01964  ? 100  ASN   A ND2  1 
ATOM   542  N  N    . LEU   A 1 96  ? -7.45388  -36.19227 18.32599  1.000 34.35592  ? 101  LEU   A N    1 
ATOM   543  C  CA   . LEU   A 1 96  ? -7.82487  -36.65115 16.99395  1.000 36.46371  ? 101  LEU   A CA   1 
ATOM   544  C  C    . LEU   A 1 96  ? -7.66173  -35.54510 15.95803  1.000 39.02842  ? 101  LEU   A C    1 
ATOM   545  O  O    . LEU   A 1 96  ? -7.74262  -34.34712 16.26810  1.000 33.34304  ? 101  LEU   A O    1 
ATOM   546  C  CB   . LEU   A 1 96  ? -9.27592  -37.15101 16.95086  1.000 36.29141  ? 101  LEU   A CB   1 
ATOM   547  C  CG   . LEU   A 1 96  ? -9.76206  -38.22603 17.93478  1.000 39.23687  ? 101  LEU   A CG   1 
ATOM   548  C  CD1  . LEU   A 1 96  ? -11.26107 -38.41987 17.77371  1.000 37.40242  ? 101  LEU   A CD1  1 
ATOM   549  C  CD2  . LEU   A 1 96  ? -9.04218  -39.55608 17.75872  1.000 37.05934  ? 101  LEU   A CD2  1 
ATOM   550  N  N    . LEU   A 1 97  ? -7.44372  -35.97605 14.71601  1.000 34.09227  ? 102  LEU   A N    1 
ATOM   551  C  CA   . LEU   A 1 97  ? -7.52959  -35.12297 13.54306  1.000 33.53850  ? 102  LEU   A CA   1 
ATOM   552  C  C    . LEU   A 1 97  ? -8.55561  -35.69581 12.58398  1.000 34.29860  ? 102  LEU   A C    1 
ATOM   553  O  O    . LEU   A 1 97  ? -8.74073  -36.91278 12.50190  1.000 33.06022  ? 102  LEU   A O    1 
ATOM   554  C  CB   . LEU   A 1 97  ? -6.19255  -35.00205 12.81612  1.000 34.66175  ? 102  LEU   A CB   1 
ATOM   555  C  CG   . LEU   A 1 97  ? -5.15950  -34.13319 13.52221  1.000 38.13109  ? 102  LEU   A CG   1 
ATOM   556  C  CD1  . LEU   A 1 97  ? -3.81748  -34.27528 12.82025  1.000 34.48240  ? 102  LEU   A CD1  1 
ATOM   557  C  CD2  . LEU   A 1 97  ? -5.64036  -32.68515 13.53228  1.000 37.86613  ? 102  LEU   A CD2  1 
ATOM   558  N  N    . VAL   A 1 98  ? -9.22350  -34.80870 11.86301  1.000 28.46815  ? 103  VAL   A N    1 
ATOM   559  C  CA   . VAL   A 1 98  ? -9.94349  -35.18055 10.65796  1.000 30.21585  ? 103  VAL   A CA   1 
ATOM   560  C  C    . VAL   A 1 98  ? -9.36137  -34.35554 9.52404   1.000 33.06739  ? 103  VAL   A C    1 
ATOM   561  O  O    . VAL   A 1 98  ? -8.94626  -33.21059 9.72712   1.000 32.11663  ? 103  VAL   A O    1 
ATOM   562  C  CB   . VAL   A 1 98  ? -11.47248 -34.98441 10.79092  1.000 29.02932  ? 103  VAL   A CB   1 
ATOM   563  C  CG1  . VAL   A 1 98  ? -11.85534 -33.49939 11.01199  1.000 29.17298  ? 103  VAL   A CG1  1 
ATOM   564  C  CG2  . VAL   A 1 98  ? -12.19649 -35.59326 9.58785   1.000 31.43087  ? 103  VAL   A CG2  1 
ATOM   565  N  N    . SER   A 1 99  ? -9.28638  -34.96247 8.34700   1.000 31.45193  ? 104  SER   A N    1 
ATOM   566  C  CA   . SER   A 1 99  ? -8.76027  -34.32544 7.15506   1.000 31.03014  ? 104  SER   A CA   1 
ATOM   567  C  C    . SER   A 1 99  ? -9.73025  -34.52328 5.99601   1.000 30.21457  ? 104  SER   A C    1 
ATOM   568  O  O    . SER   A 1 99  ? -10.43234 -35.53320 5.91292   1.000 28.71563  ? 104  SER   A O    1 
ATOM   569  C  CB   . SER   A 1 99  ? -7.39832  -34.91155 6.79007   1.000 30.53914  ? 104  SER   A CB   1 
ATOM   570  O  OG   . SER   A 1 99  ? -7.49245  -36.32154 6.69598   1.000 27.72777  ? 104  SER   A OG   1 
ATOM   571  N  N    . ALA   A 1 100 ? -9.75212  -33.55422 5.09107   1.000 31.69129  ? 105  ALA   A N    1 
ATOM   572  C  CA   . ALA   A 1 100 ? -10.64708 -33.57806 3.93804   1.000 28.95181  ? 105  ALA   A CA   1 
ATOM   573  C  C    . ALA   A 1 100 ? -9.78603  -33.56806 2.69007   1.000 27.57879  ? 105  ALA   A C    1 
ATOM   574  O  O    . ALA   A 1 100 ? -8.93494  -32.68714 2.54116   1.000 25.67666  ? 105  ALA   A O    1 
ATOM   575  C  CB   . ALA   A 1 100 ? -11.59296 -32.37297 3.94808   1.000 26.80775  ? 105  ALA   A CB   1 
ATOM   576  N  N    . SER   A 1 101 ? -10.01209 -34.52699 1.79000   1.000 27.11130  ? 106  SER   A N    1 
ATOM   577  C  CA   . SER   A 1 101 ? -9.07907  -34.77401 0.69702   1.000 28.77851  ? 106  SER   A CA   1 
ATOM   578  C  C    . SER   A 1 101 ? -9.76902  -34.75985 -0.67101  1.000 29.79206  ? 106  SER   A C    1 
ATOM   579  O  O    . SER   A 1 101 ? -10.96404 -35.05473 -0.80307  1.000 28.96427  ? 106  SER   A O    1 
ATOM   580  C  CB   . SER   A 1 101 ? -8.35321  -36.11909 0.90796   1.000 27.39843  ? 106  SER   A CB   1 
ATOM   581  O  OG   . SER   A 1 101 ? -7.55820  -36.45110 -0.20303  1.000 30.82489  ? 106  SER   A OG   1 
ATOM   582  N  N    . ASP   A 1 102 ? -8.96995  -34.48787 -1.68896  1.000 29.26730  ? 107  ASP   A N    1 
ATOM   583  C  CA   . ASP   A 1 102 ? -9.49490  -34.52573 -3.06698  1.000 31.88113  ? 107  ASP   A CA   1 
ATOM   584  C  C    . ASP   A 1 102 ? -9.76303  -35.97868 -3.46508  1.000 33.21327  ? 107  ASP   A C    1 
ATOM   585  O  O    . ASP   A 1 102 ? -10.44501 -36.18755 -4.47612  1.000 30.02457  ? 107  ASP   A O    1 
ATOM   586  C  CB   . ASP   A 1 102 ? -8.54680  -33.76877 -3.97090  1.000 33.90002  ? 107  ASP   A CB   1 
ATOM   587  C  CG   . ASP   A 1 102 ? -8.30667  -32.32081 -3.57980  1.000 38.51195  ? 107  ASP   A CG   1 
ATOM   588  O  OD1  . ASP   A 1 102 ? -9.29261  -31.60773 -3.33779  1.000 43.08039  ? 107  ASP   A OD1  1 
ATOM   589  O  OD2  . ASP   A 1 102 ? -7.13663  -31.91793 -3.52273  1.000 42.53374  ? 107  ASP   A OD2  1 
ATOM   590  N  N    . ASP   A 1 103 ? -9.26215  -36.93778 -2.68612  1.000 27.93008  ? 108  ASP   A N    1 
ATOM   591  C  CA   . ASP   A 1 103 ? -9.57528  -38.32573 -2.98722  1.000 29.89101  ? 108  ASP   A CA   1 
ATOM   592  C  C    . ASP   A 1 103 ? -11.01133 -38.68461 -2.60030  1.000 33.65393  ? 108  ASP   A C    1 
ATOM   593  O  O    . ASP   A 1 103 ? -11.37844 -39.85558 -2.61039  1.000 33.54767  ? 108  ASP   A O    1 
ATOM   594  C  CB   . ASP   A 1 103 ? -8.57239  -39.25787 -2.29324  1.000 28.98104  ? 108  ASP   A CB   1 
ATOM   595  C  CG   . ASP   A 1 103 ? -8.69045  -39.23295 -0.77325  1.000 32.58666  ? 108  ASP   A CG   1 
ATOM   596  O  OD1  . ASP   A 1 103 ? -9.73443  -38.78889 -0.22826  1.000 32.49007  ? 108  ASP   A OD1  1 
ATOM   597  O  OD2  . ASP   A 1 103 ? -7.72652  -39.68409 -0.11524  1.000 35.92943  ? 108  ASP   A OD2  1 
ATOM   598  N  N    . LYS   A 1 104 ? -11.81925 -37.70556 -2.22427  1.000 33.49498  ? 109  LYS   A N    1 
ATOM   599  C  CA   . LYS   A 1 104 ? -13.25727 -37.86243 -1.98233  1.000 32.84318  ? 109  LYS   A CA   1 
ATOM   600  C  C    . LYS   A 1 104 ? -13.54438 -38.44349 -0.60238  1.000 30.36267  ? 109  LYS   A C    1 
ATOM   601  O  O    . LYS   A 1 104 ? -14.72842 -38.70440 -0.27744  1.000 32.30918  ? 109  LYS   A O    1 
ATOM   602  C  CB   . LYS   A 1 104 ? -13.94131 -38.72130 -3.05341  1.000 32.50235  ? 109  LYS   A CB   1 
ATOM   603  C  CG   . LYS   A 1 104 ? -13.63922 -38.28324 -4.49837  1.000 32.56140  ? 109  LYS   A CG   1 
ATOM   604  C  CD   . LYS   A 1 104 ? -14.44126 -39.12710 -5.50946  1.000 34.83629  ? 109  LYS   A CD   1 
ATOM   605  C  CE   . LYS   A 1 104 ? -14.12916 -38.66104 -6.92642  1.000 48.51383  ? 109  LYS   A CE   1 
ATOM   606  N  NZ   . LYS   A 1 104 ? -14.90919 -39.39590 -7.96149  1.000 55.52569  ? 109  LYS   A NZ   1 
ATOM   607  N  N    . THR   A 1 105 ? -12.53643 -38.61364 0.24665   1.000 30.42964  ? 110  THR   A N    1 
ATOM   608  C  CA   . THR   A 1 105 ? -12.77753 -39.09970 1.59661   1.000 27.68015  ? 110  THR   A CA   1 
ATOM   609  C  C    . THR   A 1 105 ? -12.35146 -38.06281 2.63069   1.000 34.87272  ? 110  THR   A C    1 
ATOM   610  O  O    . THR   A 1 105 ? -11.61036 -37.12086 2.33778   1.000 34.48856  ? 110  THR   A O    1 
ATOM   611  C  CB   . THR   A 1 105 ? -12.01366 -40.41780 1.86655   1.000 34.37911  ? 110  THR   A CB   1 
ATOM   612  O  OG1  . THR   A 1 105 ? -10.61564 -40.13294 2.01562   1.000 35.70914  ? 110  THR   A OG1  1 
ATOM   613  C  CG2  . THR   A 1 105 ? -12.20772 -41.41270 0.71648   1.000 30.92806  ? 110  THR   A CG2  1 
ATOM   614  N  N    . LEU   A 1 106 ? -12.84453 -38.24284 3.85166   1.000 29.73622  ? 111  LEU   A N    1 
ATOM   615  C  CA   . LEU   A 1 106 ? -12.17152 -37.71098 5.01772   1.000 29.28338  ? 111  LEU   A CA   1 
ATOM   616  C  C    . LEU   A 1 106 ? -11.55366 -38.87509 5.77967   1.000 32.87222  ? 111  LEU   A C    1 
ATOM   617  O  O    . LEU   A 1 106 ? -11.94377 -40.04004 5.60858   1.000 35.45140  ? 111  LEU   A O    1 
ATOM   618  C  CB   . LEU   A 1 106 ? -13.13248 -36.93594 5.92173   1.000 29.29304  ? 111  LEU   A CB   1 
ATOM   619  C  CG   . LEU   A 1 106 ? -13.99635 -35.87681 5.23176   1.000 30.92786  ? 111  LEU   A CG   1 
ATOM   620  C  CD1  . LEU   A 1 106 ? -15.34239 -36.45966 4.77868   1.000 30.39282  ? 111  LEU   A CD1  1 
ATOM   621  C  CD2  . LEU   A 1 106 ? -14.17327 -34.66085 6.14083   1.000 25.95344  ? 111  LEU   A CD2  1 
ATOM   622  N  N    . LYS   A 1 107 ? -10.58766 -38.55123 6.62772   1.000 32.32483  ? 112  LYS   A N    1 
ATOM   623  C  CA   . LYS   A 1 107 ? -9.94779  -39.55235 7.46069   1.000 32.98276  ? 112  LYS   A CA   1 
ATOM   624  C  C    . LYS   A 1 107 ? -9.87680  -39.03644 8.88172   1.000 35.58594  ? 112  LYS   A C    1 
ATOM   625  O  O    . LYS   A 1 107 ? -9.57369  -37.85549 9.10681   1.000 33.93465  ? 112  LYS   A O    1 
ATOM   626  C  CB   . LYS   A 1 107 ? -8.55181  -39.90745 6.93072   1.000 33.94069  ? 112  LYS   A CB   1 
ATOM   627  C  CG   . LYS   A 1 107 ? -8.63986  -40.92037 5.79765   1.000 32.12974  ? 112  LYS   A CG   1 
ATOM   628  C  CD   . LYS   A 1 107 ? -7.29187  -41.22046 5.17468   1.000 33.67814  ? 112  LYS   A CD   1 
ATOM   629  C  CE   . LYS   A 1 107 ? -7.42192  -42.18238 3.97962   1.000 37.80795  ? 112  LYS   A CE   1 
ATOM   630  N  NZ   . LYS   A 1 107 ? -7.93806  -43.54635 4.37351   1.000 36.50940  ? 112  LYS   A NZ   1 
ATOM   631  N  N    . ILE   A 1 108 ? -10.20992 -39.91947 9.83565   1.000 32.18907  ? 113  ILE   A N    1 
ATOM   632  C  CA   . ILE   A 1 108 ? -10.03195 -39.64658 11.25668  1.000 32.50436  ? 113  ILE   A CA   1 
ATOM   633  C  C    . ILE   A 1 108 ? -8.73103  -40.30173 11.68069  1.000 34.69706  ? 113  ILE   A C    1 
ATOM   634  O  O    . ILE   A 1 108 ? -8.48813  -41.47374 11.36262  1.000 36.66481  ? 113  ILE   A O    1 
ATOM   635  C  CB   . ILE   A 1 108 ? -11.21903 -40.15952 12.09460  1.000 35.68208  ? 113  ILE   A CB   1 
ATOM   636  C  CG1  . ILE   A 1 108 ? -12.55596 -39.68635 11.49358  1.000 36.08634  ? 113  ILE   A CG1  1 
ATOM   637  C  CG2  . ILE   A 1 108 ? -11.10004 -39.66962 13.54764  1.000 33.83332  ? 113  ILE   A CG2  1 
ATOM   638  C  CD1  . ILE   A 1 108 ? -13.81103 -40.12328 12.32050  1.000 35.17616  ? 113  ILE   A CD1  1 
ATOM   639  N  N    . TRP   A 1 109 ? -7.88198  -39.53686 12.37177  1.000 34.33693  ? 114  TRP   A N    1 
ATOM   640  C  CA   . TRP   A 1 109 ? -6.53103  -39.94701 12.72779  1.000 34.69114  ? 114  TRP   A CA   1 
ATOM   641  C  C    . TRP   A 1 109 ? -6.33508  -39.85913 14.23380  1.000 35.38683  ? 114  TRP   A C    1 
ATOM   642  O  O    . TRP   A 1 109 ? -6.75601  -38.88812 14.86485  1.000 31.68230  ? 114  TRP   A O    1 
ATOM   643  C  CB   . TRP   A 1 109 ? -5.46092  -39.05707 12.07189  1.000 33.67070  ? 114  TRP   A CB   1 
ATOM   644  C  CG   . TRP   A 1 109 ? -5.57784  -38.84197 10.59290  1.000 34.46754  ? 114  TRP   A CG   1 
ATOM   645  C  CD1  . TRP   A 1 109 ? -6.28872  -37.85286 9.94993   1.000 34.39689  ? 114  TRP   A CD1  1 
ATOM   646  C  CD2  . TRP   A 1 109 ? -4.91888  -39.58897 9.56288   1.000 39.91888  ? 114  TRP   A CD2  1 
ATOM   647  N  NE1  . TRP   A 1 109 ? -6.13768  -37.96979 8.58693   1.000 34.05045  ? 114  TRP   A NE1  1 
ATOM   648  C  CE2  . TRP   A 1 109 ? -5.29477  -39.01785 8.32090   1.000 32.22085  ? 114  TRP   A CE2  1 
ATOM   649  C  CE3  . TRP   A 1 109 ? -4.06098  -40.69705 9.56784   1.000 37.19722  ? 114  TRP   A CE3  1 
ATOM   650  C  CZ2  . TRP   A 1 109 ? -4.84178  -39.51782 7.09988   1.000 35.15846  ? 114  TRP   A CZ2  1 
ATOM   651  C  CZ3  . TRP   A 1 109 ? -3.60499  -41.19202 8.34782   1.000 36.74995  ? 114  TRP   A CZ3  1 
ATOM   652  C  CH2  . TRP   A 1 109 ? -4.00288  -40.60491 7.13285   1.000 36.72818  ? 114  TRP   A CH2  1 
ATOM   653  N  N    . ASP   A 1 110 ? -5.66320  -40.85823 14.79977  1.000 39.64213  ? 115  ASP   A N    1 
ATOM   654  C  CA   . ASP   A 1 110 ? -5.13024  -40.74936 16.14979  1.000 37.88981  ? 115  ASP   A CA   1 
ATOM   655  C  C    . ASP   A 1 110 ? -3.75917  -40.10449 16.03789  1.000 38.80953  ? 115  ASP   A C    1 
ATOM   656  O  O    . ASP   A 1 110 ? -2.84521  -40.68954 15.44888  1.000 42.25948  ? 115  ASP   A O    1 
ATOM   657  C  CB   . ASP   A 1 110 ? -5.03140  -42.11042 16.84371  1.000 44.21751  ? 115  ASP   A CB   1 
ATOM   658  C  CG   . ASP   A 1 110 ? -4.28244  -42.03057 18.19075  1.000 46.10777  ? 115  ASP   A CG   1 
ATOM   659  O  OD1  . ASP   A 1 110 ? -4.93045  -41.74058 19.22774  1.000 52.08855  ? 115  ASP   A OD1  1 
ATOM   660  O  OD2  . ASP   A 1 110 ? -3.04446  -42.22369 18.19778  1.000 48.53162  ? 115  ASP   A OD2  1 
ATOM   661  N  N    . VAL   A 1 111 ? -3.61108  -38.91154 16.61197  1.000 37.52617  ? 116  VAL   A N    1 
ATOM   662  C  CA   . VAL   A 1 111 ? -2.41599  -38.12064 16.33606  1.000 40.70491  ? 116  VAL   A CA   1 
ATOM   663  C  C    . VAL   A 1 111 ? -1.18708  -38.75880 16.97907  1.000 42.64572  ? 116  VAL   A C    1 
ATOM   664  O  O    . VAL   A 1 111 ? -0.13407  -38.88586 16.34110  1.000 37.64944  ? 116  VAL   A O    1 
ATOM   665  C  CB   . VAL   A 1 111 ? -2.60987  -36.65965 16.78715  1.000 40.98641  ? 116  VAL   A CB   1 
ATOM   666  C  CG1  . VAL   A 1 111 ? -2.93892  -36.58871 18.26314  1.000 44.97318  ? 116  VAL   A CG1  1 
ATOM   667  C  CG2  . VAL   A 1 111 ? -1.35177  -35.84075 16.47925  1.000 38.93407  ? 116  VAL   A CG2  1 
ATOM   668  N  N    . SER   A 1 112 ? -1.29817  -39.18087 18.24604  1.000 42.63559  ? 117  SER   A N    1 
ATOM   669  C  CA   . SER   A 1 112 ? -0.10824  -39.70303 18.91805  1.000 45.55052  ? 117  SER   A CA   1 
ATOM   670  C  C    . SER   A 1 112 ? 0.41266   -40.96103 18.22299  1.000 42.96119  ? 117  SER   A C    1 
ATOM   671  O  O    . SER   A 1 112 ? 1.62964   -41.16715 18.14902  1.000 49.69485  ? 117  SER   A O    1 
ATOM   672  C  CB   . SER   A 1 112 ? -0.39632  -39.95609 20.40402  1.000 43.49537  ? 117  SER   A CB   1 
ATOM   673  O  OG   . SER   A 1 112 ? -1.41642  -40.92100 20.59192  1.000 52.40654  ? 117  SER   A OG   1 
ATOM   674  N  N    . SER   A 1 113 ? -0.47840  -41.78391 17.66291  1.000 41.68216  ? 118  SER   A N    1 
ATOM   675  C  CA   . SER   A 1 113 ? -0.05549  -42.98291 16.94885  1.000 44.47866  ? 118  SER   A CA   1 
ATOM   676  C  C    . SER   A 1 113 ? 0.13759   -42.76183 15.45887  1.000 45.40578  ? 118  SER   A C    1 
ATOM   677  O  O    . SER   A 1 113 ? 0.85554   -43.54286 14.82585  1.000 46.37066  ? 118  SER   A O    1 
ATOM   678  C  CB   . SER   A 1 113 ? -1.06860  -44.11382 17.14274  1.000 45.36104  ? 118  SER   A CB   1 
ATOM   679  O  OG   . SER   A 1 113 ? -2.21155  -43.92966 16.31570  1.000 47.76410  ? 118  SER   A OG   1 
ATOM   680  N  N    . GLY   A 1 114 ? -0.48529  -41.73673 14.88191  1.000 44.71282  ? 119  GLY   A N    1 
ATOM   681  C  CA   . GLY   A 1 114 ? -0.42121  -41.52365 13.45292  1.000 39.60020  ? 119  GLY   A CA   1 
ATOM   682  C  C    . GLY   A 1 114 ? -1.32727  -42.41451 12.62683  1.000 44.90278  ? 119  GLY   A C    1 
ATOM   683  O  O    . GLY   A 1 114 ? -1.28021  -42.34344 11.39684  1.000 43.51262  ? 119  GLY   A O    1 
ATOM   684  N  N    . LYS   A 1 115 ? -2.15937  -43.24247 13.25175  1.000 41.79488  ? 120  LYS   A N    1 
ATOM   685  C  CA   . LYS   A 1 115 ? -2.91544  -44.24735 12.52166  1.000 41.08622  ? 120  LYS   A CA   1 
ATOM   686  C  C    . LYS   A 1 115 ? -4.28337  -43.73119 12.07964  1.000 41.29861  ? 120  LYS   A C    1 
ATOM   687  O  O    . LYS   A 1 115 ? -4.93332  -42.94417 12.77266  1.000 35.60553  ? 120  LYS   A O    1 
ATOM   688  C  CB   . LYS   A 1 115 ? -3.08660  -45.50239 13.38057  1.000 47.33730  ? 120  LYS   A CB   1 
ATOM   689  C  CG   . LYS   A 1 115 ? -1.79968  -46.32552 13.52557  1.000 54.55707  ? 120  LYS   A CG   1 
ATOM   690  C  CD   . LYS   A 1 115 ? -1.91683  -47.38458 14.63050  1.000 63.82812  ? 120  LYS   A CD   1 
ATOM   691  C  CE   . LYS   A 1 115 ? -0.76492  -48.38969 14.57748  1.000 64.41729  ? 120  LYS   A CE   1 
ATOM   692  N  NZ   . LYS   A 1 115 ? -1.21607  -49.76067 14.97338  1.000 71.77309  ? 120  LYS   A NZ   1 
ATOM   693  N  N    . CYS   A 1 116 ? -4.72838  -44.21207 10.91759  1.000 36.99003  ? 121  CYS   A N    1 
ATOM   694  C  CA   . CYS   A 1 116 ? -6.05032  -43.86591 10.40856  1.000 40.11272  ? 121  CYS   A CA   1 
ATOM   695  C  C    . CYS   A 1 116 ? -7.10243  -44.72285 11.10547  1.000 39.51636  ? 121  CYS   A C    1 
ATOM   696  O  O    . CYS   A 1 116 ? -7.11655  -45.94784 10.96039  1.000 40.47382  ? 121  CYS   A O    1 
ATOM   697  C  CB   . CYS   A 1 116 ? -6.10328  -44.04481 8.89355   1.000 38.55518  ? 121  CYS   A CB   1 
ATOM   698  S  SG   . CYS   A 1 116 ? -7.73523  -43.73661 8.22351   1.000 41.14587  ? 121  CYS   A SG   1 
ATOM   699  N  N    . LEU   A 1 117 ? -7.98240  -44.07782 11.86648  1.000 35.46172  ? 122  LEU   A N    1 
ATOM   700  C  CA   . LEU   A 1 117 ? -9.01150  -44.80976 12.59739  1.000 40.81485  ? 122  LEU   A CA   1 
ATOM   701  C  C    . LEU   A 1 117 ? -10.21750 -45.11459 11.71833  1.000 42.78275  ? 122  LEU   A C    1 
ATOM   702  O  O    . LEU   A 1 117 ? -10.81460 -46.19154 11.82224  1.000 39.85562  ? 122  LEU   A O    1 
ATOM   703  C  CB   . LEU   A 1 117 ? -9.44347  -44.01380 13.82842  1.000 34.53271  ? 122  LEU   A CB   1 
ATOM   704  C  CG   . LEU   A 1 117 ? -8.30447  -43.62097 14.78249  1.000 39.71644  ? 122  LEU   A CG   1 
ATOM   705  C  CD1  . LEU   A 1 117 ? -8.84244  -42.89199 16.01852  1.000 39.62278  ? 122  LEU   A CD1  1 
ATOM   706  C  CD2  . LEU   A 1 117 ? -7.48160  -44.84907 15.17845  1.000 40.41714  ? 122  LEU   A CD2  1 
ATOM   707  N  N    . LYS   A 1 118 ? -10.59837 -44.17450 10.85837  1.000 40.08840  ? 123  LYS   A N    1 
ATOM   708  C  CA   . LYS   A 1 118 ? -11.75236 -44.35833 9.99032   1.000 40.55237  ? 123  LYS   A CA   1 
ATOM   709  C  C    . LYS   A 1 118 ? -11.50223 -43.58728 8.71037   1.000 36.25289  ? 123  LYS   A C    1 
ATOM   710  O  O    . LYS   A 1 118 ? -10.86913 -42.52834 8.73346   1.000 36.33842  ? 123  LYS   A O    1 
ATOM   711  C  CB   . LYS   A 1 118 ? -13.04233 -43.85125 10.64630  1.000 41.07030  ? 123  LYS   A CB   1 
ATOM   712  C  CG   . LYS   A 1 118 ? -13.50345 -44.60428 11.88623  1.000 45.50695  ? 123  LYS   A CG   1 
ATOM   713  C  CD   . LYS   A 1 118 ? -14.33356 -45.82418 11.49013  1.000 48.38800  ? 123  LYS   A CD   1 
ATOM   714  C  CE   . LYS   A 1 118 ? -14.97466 -46.46419 12.70606  1.000 46.62401  ? 123  LYS   A CE   1 
ATOM   715  N  NZ   . LYS   A 1 118 ? -13.94573 -46.68636 13.75809  1.000 51.80122  ? 123  LYS   A NZ   1 
ATOM   716  N  N    . THR   A 1 119 ? -12.01024 -44.11816 7.60132   1.000 36.35838  ? 124  THR   A N    1 
ATOM   717  C  CA   . THR   A 1 119 ? -12.10412 -43.39107 6.34536   1.000 36.37585  ? 124  THR   A CA   1 
ATOM   718  C  C    . THR   A 1 119 ? -13.58609 -43.16191 6.06232   1.000 44.10099  ? 124  THR   A C    1 
ATOM   719  O  O    . THR   A 1 119 ? -14.36518 -44.12483 5.99023   1.000 40.03494  ? 124  THR   A O    1 
ATOM   720  C  CB   . THR   A 1 119 ? -11.43316 -44.16906 5.21734   1.000 36.21972  ? 124  THR   A CB   1 
ATOM   721  O  OG1  . THR   A 1 119 ? -10.04018 -44.31522 5.51438   1.000 32.72123  ? 124  THR   A OG1  1 
ATOM   722  C  CG2  . THR   A 1 119 ? -11.58703 -43.43596 3.86838   1.000 34.15270  ? 124  THR   A CG2  1 
ATOM   723  N  N    . LEU   A 1 120 ? -13.98496 -41.89086 5.94439   1.000 40.12886  ? 125  LEU   A N    1 
ATOM   724  C  CA   . LEU   A 1 120 ? -15.39092 -41.52871 5.72936   1.000 36.40765  ? 125  LEU   A CA   1 
ATOM   725  C  C    . LEU   A 1 120 ? -15.63085 -41.41059 4.22735   1.000 38.35302  ? 125  LEU   A C    1 
ATOM   726  O  O    . LEU   A 1 120 ? -15.08574 -40.51360 3.56643   1.000 38.17943  ? 125  LEU   A O    1 
ATOM   727  C  CB   . LEU   A 1 120 ? -15.75682 -40.22672 6.44342   1.000 36.72672  ? 125  LEU   A CB   1 
ATOM   728  C  CG   . LEU   A 1 120 ? -15.22185 -40.00386 7.86646   1.000 36.54561  ? 125  LEU   A CG   1 
ATOM   729  C  CD1  . LEU   A 1 120 ? -15.92176 -38.82184 8.54351   1.000 34.04804  ? 125  LEU   A CD1  1 
ATOM   730  C  CD2  . LEU   A 1 120 ? -15.32001 -41.26591 8.72037   1.000 39.02400  ? 125  LEU   A CD2  1 
ATOM   731  N  N    . LYS   A 1 121 ? -16.42892 -42.32348 3.69127   1.000 37.72171  ? 126  LYS   A N    1 
ATOM   732  C  CA   . LYS   A 1 121 ? -16.70987 -42.39336 2.26625   1.000 36.81759  ? 126  LYS   A CA   1 
ATOM   733  C  C    . LYS   A 1 121 ? -18.18684 -42.12121 2.04321   1.000 39.54579  ? 126  LYS   A C    1 
ATOM   734  O  O    . LYS   A 1 121 ? -19.02891 -42.53118 2.84615   1.000 40.44178  ? 126  LYS   A O    1 
ATOM   735  C  CB   . LYS   A 1 121 ? -16.33098 -43.74537 1.69618   1.000 34.51010  ? 126  LYS   A CB   1 
ATOM   736  C  CG   . LYS   A 1 121 ? -14.89203 -44.13252 1.95321   1.000 43.25423  ? 126  LYS   A CG   1 
ATOM   737  C  CD   . LYS   A 1 121 ? -14.46210 -45.22650 0.98016   1.000 44.14551  ? 126  LYS   A CD   1 
ATOM   738  C  CE   . LYS   A 1 121 ? -13.31220 -46.07065 1.54615   1.000 52.48846  ? 126  LYS   A CE   1 
ATOM   739  N  NZ   . LYS   A 1 121 ? -12.42722 -46.65967 0.47615   1.000 62.75231  ? 126  LYS   A NZ   1 
ATOM   740  N  N    . GLY   A 1 122 ? -18.49473 -41.42311 0.95124   1.000 36.02603  ? 127  GLY   A N    1 
ATOM   741  C  CA   . GLY   A 1 122 ? -19.85568 -41.00496 0.69622   1.000 33.82390  ? 127  GLY   A CA   1 
ATOM   742  C  C    . GLY   A 1 122 ? -19.92553 -39.79190 -0.20671  1.000 37.00102  ? 127  GLY   A C    1 
ATOM   743  O  O    . GLY   A 1 122 ? -20.80849 -39.72676 -1.06374  1.000 33.90222  ? 127  GLY   A O    1 
ATOM   744  N  N    . HIS   A 1 123 ? -19.02844 -38.81700 -0.02361  1.000 35.83454  ? 128  HIS   A N    1 
ATOM   745  C  CA   . HIS   A 1 123 ? -18.93929 -37.71894 -0.97754  1.000 36.05743  ? 128  HIS   A CA   1 
ATOM   746  C  C    . HIS   A 1 123 ? -18.61229 -38.25489 -2.36356  1.000 35.69145  ? 128  HIS   A C    1 
ATOM   747  O  O    . HIS   A 1 123 ? -17.84838 -39.21295 -2.51259  1.000 33.32439  ? 128  HIS   A O    1 
ATOM   748  C  CB   . HIS   A 1 123 ? -17.88621 -36.70407 -0.53744  1.000 32.64212  ? 128  HIS   A CB   1 
ATOM   749  C  CG   . HIS   A 1 123 ? -18.37616 -35.77109 0.51860   1.000 29.10687  ? 128  HIS   A CG   1 
ATOM   750  N  ND1  . HIS   A 1 123 ? -19.52408 -35.02097 0.36561   1.000 28.80044  ? 128  HIS   A ND1  1 
ATOM   751  C  CD2  . HIS   A 1 123 ? -17.89218 -35.47522 1.74464   1.000 27.42172  ? 128  HIS   A CD2  1 
ATOM   752  C  CE1  . HIS   A 1 123 ? -19.72205 -34.29702 1.45265   1.000 28.68301  ? 128  HIS   A CE1  1 
ATOM   753  N  NE2  . HIS   A 1 123 ? -18.74511 -34.55317 2.30467   1.000 28.13209  ? 128  HIS   A NE2  1 
ATOM   754  N  N    . SER   A 1 124 ? -19.20920 -37.64277 -3.38455  1.000 31.86546  ? 129  SER   A N    1 
ATOM   755  C  CA   . SER   A 1 124 ? -18.96718 -38.04970 -4.75656  1.000 34.06509  ? 129  SER   A CA   1 
ATOM   756  C  C    . SER   A 1 124 ? -17.89408 -37.22176 -5.45147  1.000 31.09576  ? 129  SER   A C    1 
ATOM   757  O  O    . SER   A 1 124 ? -17.61806 -37.46572 -6.62547  1.000 31.55942  ? 129  SER   A O    1 
ATOM   758  C  CB   . SER   A 1 124 ? -20.27315 -38.00053 -5.56261  1.000 34.51097  ? 129  SER   A CB   1 
ATOM   759  O  OG   . SER   A 1 124 ? -20.92203 -36.74947 -5.42655  1.000 39.40542  ? 129  SER   A OG   1 
ATOM   760  N  N    . ASN   A 1 125 ? -17.26701 -36.26987 -4.76139  1.000 33.01901  ? 130  ASN   A N    1 
ATOM   761  C  CA   . ASN   A 1 125 ? -16.17091 -35.50994 -5.35330  1.000 32.38526  ? 130  ASN   A CA   1 
ATOM   762  C  C    . ASN   A 1 125 ? -15.33190 -34.92209 -4.22123  1.000 33.40991  ? 130  ASN   A C    1 
ATOM   763  O  O    . ASN   A 1 125 ? -15.54797 -35.23414 -3.04625  1.000 28.18725  ? 130  ASN   A O    1 
ATOM   764  C  CB   . ASN   A 1 125 ? -16.69377 -34.43183 -6.31425  1.000 30.51463  ? 130  ASN   A CB   1 
ATOM   765  C  CG   . ASN   A 1 125 ? -15.78571 -34.25984 -7.51920  1.000 33.95585  ? 130  ASN   A CG   1 
ATOM   766  O  OD1  . ASN   A 1 125 ? -14.56872 -34.36697 -7.39316  1.000 32.93902  ? 130  ASN   A OD1  1 
ATOM   767  N  ND2  . ASN   A 1 125 ? -16.37364 -34.02071 -8.69921  1.000 33.90767  ? 130  ASN   A ND2  1 
ATOM   768  N  N    . TYR   A 1 126 ? -14.38580 -34.03716 -4.58014  1.000 28.04658  ? 131  TYR   A N    1 
ATOM   769  C  CA   . TYR   A 1 126 ? -13.41079 -33.54432 -3.61007  1.000 30.02513  ? 131  TYR   A CA   1 
ATOM   770  C  C    . TYR   A 1 126 ? -14.09879 -33.03033 -2.35506  1.000 28.11394  ? 131  TYR   A C    1 
ATOM   771  O  O    . TYR   A 1 126 ? -15.09671 -32.30823 -2.42805  1.000 26.58517  ? 131  TYR   A O    1 
ATOM   772  C  CB   . TYR   A 1 126 ? -12.56666 -32.41036 -4.18996  1.000 30.29460  ? 131  TYR   A CB   1 
ATOM   773  C  CG   . TYR   A 1 126 ? -12.29861 -32.47629 -5.66596  1.000 31.30697  ? 131  TYR   A CG   1 
ATOM   774  C  CD1  . TYR   A 1 126 ? -11.31667 -33.31936 -6.18697  1.000 35.33047  ? 131  TYR   A CD1  1 
ATOM   775  C  CD2  . TYR   A 1 126 ? -13.00349 -31.66117 -6.54793  1.000 33.69567  ? 131  TYR   A CD2  1 
ATOM   776  C  CE1  . TYR   A 1 126 ? -11.04762 -33.36030 -7.56597  1.000 40.39416  ? 131  TYR   A CE1  1 
ATOM   777  C  CE2  . TYR   A 1 126 ? -12.74245 -31.69711 -7.91793  1.000 41.35419  ? 131  TYR   A CE2  1 
ATOM   778  C  CZ   . TYR   A 1 126 ? -11.76851 -32.55117 -8.41794  1.000 40.33114  ? 131  TYR   A CZ   1 
ATOM   779  O  OH   . TYR   A 1 126 ? -11.52546 -32.57811 -9.76894  1.000 44.42135  ? 131  TYR   A OH   1 
ATOM   780  N  N    . VAL   A 1 127 ? -13.52386 -33.37846 -1.20406  1.000 25.53768  ? 132  VAL   A N    1 
ATOM   781  C  CA   . VAL   A 1 127 ? -13.95887 -32.89350 0.09495   1.000 25.85209  ? 132  VAL   A CA   1 
ATOM   782  C  C    . VAL   A 1 127 ? -13.07576 -31.71060 0.46306   1.000 27.46843  ? 132  VAL   A C    1 
ATOM   783  O  O    . VAL   A 1 127 ? -11.85778 -31.85373 0.58710   1.000 26.89046  ? 132  VAL   A O    1 
ATOM   784  C  CB   . VAL   A 1 127 ? -13.88101 -34.00257 1.15389   1.000 25.46852  ? 132  VAL   A CB   1 
ATOM   785  C  CG1  . VAL   A 1 127 ? -14.61802 -33.57858 2.41988   1.000 24.38164  ? 132  VAL   A CG1  1 
ATOM   786  C  CG2  . VAL   A 1 127 ? -14.42612 -35.31148 0.57878   1.000 28.53468  ? 132  VAL   A CG2  1 
ATOM   787  N  N    . PHE   A 1 128 ? -13.68166 -30.54256 0.64911   1.000 26.61328  ? 133  PHE   A N    1 
ATOM   788  C  CA   . PHE   A 1 128 ? -12.92754 -29.30964 0.80422   1.000 27.19224  ? 133  PHE   A CA   1 
ATOM   789  C  C    . PHE   A 1 128 ? -12.76556 -28.86075 2.24525   1.000 28.69142  ? 133  PHE   A C    1 
ATOM   790  O  O    . PHE   A 1 128 ? -11.81050 -28.14186 2.54733   1.000 27.44528  ? 133  PHE   A O    1 
ATOM   791  C  CB   . PHE   A 1 128 ? -13.60040 -28.17653 0.02226   1.000 25.80445  ? 133  PHE   A CB   1 
ATOM   792  C  CG   . PHE   A 1 128 ? -13.42036 -28.27745 -1.45974  1.000 24.63836  ? 133  PHE   A CG   1 
ATOM   793  C  CD1  . PHE   A 1 128 ? -12.29640 -28.86653 -1.99273  1.000 25.66140  ? 133  PHE   A CD1  1 
ATOM   794  C  CD2  . PHE   A 1 128 ? -14.37728 -27.76030 -2.32374  1.000 27.38270  ? 133  PHE   A CD2  1 
ATOM   795  C  CE1  . PHE   A 1 128 ? -12.12135 -28.92746 -3.36273  1.000 28.66405  ? 133  PHE   A CE1  1 
ATOM   796  C  CE2  . PHE   A 1 128 ? -14.20423 -27.82623 -3.69274  1.000 27.52038  ? 133  PHE   A CE2  1 
ATOM   797  C  CZ   . PHE   A 1 128 ? -13.08227 -28.41931 -4.21273  1.000 27.14200  ? 133  PHE   A CZ   1 
ATOM   798  N  N    . CYS   A 1 129 ? -13.67663 -29.23571 3.14219   1.000 25.87211  ? 134  CYS   A N    1 
ATOM   799  C  CA   . CYS   A 1 129 ? -13.68062 -28.61980 4.45623   1.000 25.58205  ? 134  CYS   A CA   1 
ATOM   800  C  C    . CYS   A 1 129 ? -14.20475 -29.62481 5.47715   1.000 27.62240  ? 134  CYS   A C    1 
ATOM   801  O  O    . CYS   A 1 129 ? -14.98783 -30.51871 5.14606   1.000 23.84225  ? 134  CYS   A O    1 
ATOM   802  C  CB   . CYS   A 1 129 ? -14.51549 -27.32871 4.43328   1.000 23.86480  ? 134  CYS   A CB   1 
ATOM   803  S  SG   . CYS   A 1 129 ? -16.14947 -27.47950 3.53721   1.000 27.16386  ? 134  CYS   A SG   1 
ATOM   804  N  N    . CYS   A 1 130 ? -13.74279 -29.49093 6.72117   1.000 27.59627  ? 135  CYS   A N    1 
ATOM   805  C  CA   . CYS   A 1 130 ? -14.16292 -30.43996 7.74710   1.000 30.26938  ? 135  CYS   A CA   1 
ATOM   806  C  C    . CYS   A 1 130 ? -13.97291 -29.82306 9.12615   1.000 30.56626  ? 135  CYS   A C    1 
ATOM   807  O  O    . CYS   A 1 130 ? -13.17683 -28.89815 9.31623   1.000 25.79869  ? 135  CYS   A O    1 
ATOM   808  C  CB   . CYS   A 1 130 ? -13.38504 -31.75303 7.64205   1.000 30.03707  ? 135  CYS   A CB   1 
ATOM   809  S  SG   . CYS   A 1 130 ? -11.59102 -31.47220 7.67513   1.000 27.76998  ? 135  CYS   A SG   1 
ATOM   810  N  N    . ASN   A 1 131 ? -14.70500 -30.37205 10.09308  1.000 28.95730  ? 136  ASN   A N    1 
ATOM   811  C  CA   . ASN   A 1 131 ? -14.64901 -29.90814 11.47311  1.000 31.72474  ? 136  ASN   A CA   1 
ATOM   812  C  C    . ASN   A 1 131 ? -15.33214 -30.94213 12.36602  1.000 33.72908  ? 136  ASN   A C    1 
ATOM   813  O  O    . ASN   A 1 131 ? -16.30419 -31.59101 11.94795  1.000 29.60284  ? 136  ASN   A O    1 
ATOM   814  C  CB   . ASN   A 1 131 ? -15.34188 -28.54609 11.63517  1.000 31.72242  ? 136  ASN   A CB   1 
ATOM   815  C  CG   . ASN   A 1 131 ? -14.37578 -27.40919 11.76428  1.000 35.57205  ? 136  ASN   A CG   1 
ATOM   816  O  OD1  . ASN   A 1 131 ? -13.39181 -27.50133 12.49431  1.000 34.41607  ? 136  ASN   A OD1  1 
ATOM   817  N  ND2  . ASN   A 1 131 ? -14.64364 -26.31012 11.03934  1.000 33.54431  ? 136  ASN   A ND2  1 
ATOM   818  N  N    . PHE   A 1 132 ? -14.80620 -31.08526 13.58503  1.000 35.48326  ? 137  PHE   A N    1 
ATOM   819  C  CA   . PHE   A 1 132 ? -15.48231 -31.79426 14.67096  1.000 32.05102  ? 137  PHE   A CA   1 
ATOM   820  C  C    . PHE   A 1 132 ? -16.52325 -30.88120 15.31298  1.000 32.78615  ? 137  PHE   A C    1 
ATOM   821  O  O    . PHE   A 1 132 ? -16.36113 -29.66222 15.33306  1.000 30.33539  ? 137  PHE   A O    1 
ATOM   822  C  CB   . PHE   A 1 132 ? -14.48939 -32.20343 15.76098  1.000 30.94024  ? 137  PHE   A CB   1 
ATOM   823  C  CG   . PHE   A 1 132 ? -13.61150 -33.38149 15.41494  1.000 31.47202  ? 137  PHE   A CG   1 
ATOM   824  C  CD1  . PHE   A 1 132 ? -14.03463 -34.68047 15.67984  1.000 32.80958  ? 137  PHE   A CD1  1 
ATOM   825  C  CD2  . PHE   A 1 132 ? -12.33446 -33.18658 14.89700  1.000 29.33130  ? 137  PHE   A CD2  1 
ATOM   826  C  CE1  . PHE   A 1 132 ? -13.20573 -35.76853 15.38780  1.000 35.22200  ? 137  PHE   A CE1  1 
ATOM   827  C  CE2  . PHE   A 1 132 ? -11.50255 -34.25965 14.61096  1.000 31.53884  ? 137  PHE   A CE2  1 
ATOM   828  C  CZ   . PHE   A 1 132 ? -11.93268 -35.55262 14.85086  1.000 30.16337  ? 137  PHE   A CZ   1 
ATOM   829  N  N    . ASN   A 1 133 ? -17.59233 -31.47413 15.86290  1.000 29.08316  ? 138  ASN   A N    1 
ATOM   830  C  CA   . ASN   A 1 133 ? -18.37628 -30.67112 16.79692  1.000 35.99196  ? 138  ASN   A CA   1 
ATOM   831  C  C    . ASN   A 1 133 ? -17.66333 -30.60127 18.14996  1.000 34.47607  ? 138  ASN   A C    1 
ATOM   832  O  O    . ASN   A 1 133 ? -16.75542 -31.38538 18.42194  1.000 37.24254  ? 138  ASN   A O    1 
ATOM   833  C  CB   . ASN   A 1 133 ? -19.79434 -31.22299 16.96384  1.000 31.12627  ? 138  ASN   A CB   1 
ATOM   834  C  CG   . ASN   A 1 133 ? -19.83150 -32.63102 17.53375  1.000 35.83892  ? 138  ASN   A CG   1 
ATOM   835  O  OD1  . ASN   A 1 133 ? -18.81457 -33.33412 17.60974  1.000 34.54143  ? 138  ASN   A OD1  1 
ATOM   836  N  ND2  . ASN   A 1 133 ? -21.04056 -33.07093 17.90467  1.000 31.65966  ? 138  ASN   A ND2  1 
ATOM   837  N  N    . PRO   A 1 134 ? -18.02527 -29.63729 19.00100  1.000 35.07887  ? 139  PRO   A N    1 
ATOM   838  C  CA   . PRO   A 1 134 ? -17.34831 -29.53944 20.30203  1.000 37.02103  ? 139  PRO   A CA   1 
ATOM   839  C  C    . PRO   A 1 134 ? -17.47246 -30.81848 21.11495  1.000 38.99283  ? 139  PRO   A C    1 
ATOM   840  O  O    . PRO   A 1 134 ? -16.53653 -31.18261 21.83496  1.000 37.51766  ? 139  PRO   A O    1 
ATOM   841  C  CB   . PRO   A 1 134 ? -18.05622 -28.35941 20.98308  1.000 42.59772  ? 139  PRO   A CB   1 
ATOM   842  C  CG   . PRO   A 1 134 ? -18.64310 -27.55728 19.84811  1.000 37.87976  ? 139  PRO   A CG   1 
ATOM   843  C  CD   . PRO   A 1 134 ? -19.03516 -28.57618 18.81803  1.000 35.82838  ? 139  PRO   A CD   1 
ATOM   844  N  N    . GLN   A 1 135 ? -18.59153 -31.53836 20.98886  1.000 32.24838  ? 140  GLN   A N    1 
ATOM   845  C  CA   . GLN   A 1 135 ? -18.72868 -32.80839 21.68878  1.000 36.43971  ? 140  GLN   A CA   1 
ATOM   846  C  C    . GLN   A 1 135 ? -17.81676 -33.89644 21.11474  1.000 43.48361  ? 140  GLN   A C    1 
ATOM   847  O  O    . GLN   A 1 135 ? -17.63089 -34.92950 21.76869  1.000 41.91849  ? 140  GLN   A O    1 
ATOM   848  C  CB   . GLN   A 1 135 ? -20.20372 -33.25724 21.67069  1.000 41.33441  ? 140  GLN   A CB   1 
ATOM   849  C  CG   . GLN   A 1 135 ? -21.17166 -32.31720 22.44771  1.000 41.09708  ? 140  GLN   A CG   1 
ATOM   850  C  CD   . GLN   A 1 135 ? -21.46850 -30.96013 21.73079  1.000 47.62056  ? 140  GLN   A CD   1 
ATOM   851  O  OE1  . GLN   A 1 135 ? -21.16744 -30.76708 20.52681  1.000 35.98149  ? 140  GLN   A OE1  1 
ATOM   852  N  NE2  . GLN   A 1 135 ? -22.06244 -30.02012 22.48383  1.000 45.11852  ? 140  GLN   A NE2  1 
ATOM   853  N  N    . SER   A 1 136 ? -17.25570 -33.69242 19.91478  1.000 31.27753  ? 141  SER   A N    1 
ATOM   854  C  CA   . SER   A 1 136 ? -16.30676 -34.61147 19.28576  1.000 33.92198  ? 141  SER   A CA   1 
ATOM   855  C  C    . SER   A 1 136 ? -16.92588 -35.94539 18.90265  1.000 37.92770  ? 141  SER   A C    1 
ATOM   856  O  O    . SER   A 1 136 ? -16.19796 -36.92345 18.66061  1.000 34.50181  ? 141  SER   A O    1 
ATOM   857  C  CB   . SER   A 1 136 ? -15.09282 -34.87265 20.18079  1.000 42.16547  ? 141  SER   A CB   1 
ATOM   858  O  OG   . SER   A 1 136 ? -14.52072 -33.65773 20.60588  1.000 51.89628  ? 141  SER   A OG   1 
ATOM   859  N  N    . ASN   A 1 137 ? -18.25288 -36.04026 18.86459  1.000 33.02749  ? 142  ASN   A N    1 
ATOM   860  C  CA   . ASN   A 1 137 ? -18.87798 -37.25017 18.36349  1.000 31.19916  ? 142  ASN   A CA   1 
ATOM   861  C  C    . ASN   A 1 137 ? -19.40091 -37.08203 16.94748  1.000 33.54366  ? 142  ASN   A C    1 
ATOM   862  O  O    . ASN   A 1 137 ? -19.96498 -38.02894 16.40540  1.000 30.93631  ? 142  ASN   A O    1 
ATOM   863  C  CB   . ASN   A 1 137 ? -20.01606 -37.72411 19.29942  1.000 32.69535  ? 142  ASN   A CB   1 
ATOM   864  C  CG   . ASN   A 1 137 ? -21.02697 -36.61904 19.63545  1.000 38.22631  ? 142  ASN   A CG   1 
ATOM   865  O  OD1  . ASN   A 1 137 ? -21.19185 -35.66297 18.88350  1.000 38.76647  ? 142  ASN   A OD1  1 
ATOM   866  N  ND2  . ASN   A 1 137 ? -21.71203 -36.75604 20.78142  1.000 33.74896  ? 142  ASN   A ND2  1 
ATOM   867  N  N    . LEU   A 1 138 ? -19.24878 -35.90800 16.34056  1.000 33.12201  ? 143  LEU   A N    1 
ATOM   868  C  CA   . LEU   A 1 138 ? -19.68170 -35.70487 14.96756  1.000 32.41615  ? 143  LEU   A CA   1 
ATOM   869  C  C    . LEU   A 1 138 ? -18.58461 -35.00693 14.17464  1.000 33.17767  ? 143  LEU   A C    1 
ATOM   870  O  O    . LEU   A 1 138 ? -17.82855 -34.18704 14.70372  1.000 29.65985  ? 143  LEU   A O    1 
ATOM   871  C  CB   . LEU   A 1 138 ? -20.95962 -34.84375 14.89356  1.000 34.09954  ? 143  LEU   A CB   1 
ATOM   872  C  CG   . LEU   A 1 138 ? -22.29368 -35.28065 15.50149  1.000 35.18994  ? 143  LEU   A CG   1 
ATOM   873  C  CD1  . LEU   A 1 138 ? -23.33757 -34.18854 15.22751  1.000 32.43610  ? 143  LEU   A CD1  1 
ATOM   874  C  CD2  . LEU   A 1 138 ? -22.73679 -36.61457 14.92439  1.000 30.48656  ? 143  LEU   A CD2  1 
ATOM   875  N  N    . ILE   A 1 139 ? -18.53059 -35.31385 12.88263  1.000 36.64976  ? 144  ILE   A N    1 
ATOM   876  C  CA   . ILE   A 1 139 ? -17.75047 -34.53287 11.93271  1.000 34.83689  ? 144  ILE   A CA   1 
ATOM   877  C  C    . ILE   A 1 139 ? -18.69538 -33.98971 10.86770  1.000 33.08270  ? 144  ILE   A C    1 
ATOM   878  O  O    . ILE   A 1 139 ? -19.60943 -34.69760 10.42062  1.000 33.80035  ? 144  ILE   A O    1 
ATOM   879  C  CB   . ILE   A 1 139 ? -16.61153 -35.37194 11.31570  1.000 36.49145  ? 144  ILE   A CB   1 
ATOM   880  C  CG1  . ILE   A 1 139 ? -15.47659 -35.51212 12.34673  1.000 31.12331  ? 144  ILE   A CG1  1 
ATOM   881  C  CG2  . ILE   A 1 139 ? -16.11242 -34.73891 9.98675   1.000 31.94764  ? 144  ILE   A CG2  1 
ATOM   882  C  CD1  . ILE   A 1 139 ? -14.40467 -36.50820 11.95171  1.000 35.37985  ? 144  ILE   A CD1  1 
ATOM   883  N  N    . VAL   A 1 140 ? -18.50024 -32.71871 10.50179  1.000 28.38270  ? 145  VAL   A N    1 
ATOM   884  C  CA   . VAL   A 1 140 ? -19.19314 -32.08457 9.38680   1.000 29.22462  ? 145  VAL   A CA   1 
ATOM   885  C  C    . VAL   A 1 140 ? -18.17908 -31.89660 8.26285   1.000 30.29515  ? 145  VAL   A C    1 
ATOM   886  O  O    . VAL   A 1 140 ? -16.99706 -31.62073 8.51692   1.000 29.31564  ? 145  VAL   A O    1 
ATOM   887  C  CB   . VAL   A 1 140 ? -19.84603 -30.74553 9.79686   1.000 28.81565  ? 145  VAL   A CB   1 
ATOM   888  C  CG1  . VAL   A 1 140 ? -18.80494 -29.71466 10.21397  1.000 27.21810  ? 145  VAL   A CG1  1 
ATOM   889  C  CG2  . VAL   A 1 140 ? -20.71793 -30.21738 8.68386   1.000 29.97552  ? 145  VAL   A CG2  1 
ATOM   890  N  N    . SER   A 1 141 ? -18.62205 -32.12748 7.02782   1.000 27.39688  ? 146  SER   A N    1 
ATOM   891  C  CA   . SER   A 1 141 ? -17.77800 -32.02949 5.84686   1.000 29.11598  ? 146  SER   A CA   1 
ATOM   892  C  C    . SER   A 1 141 ? -18.53989 -31.28734 4.76288   1.000 31.31310  ? 146  SER   A C    1 
ATOM   893  O  O    . SER   A 1 141 ? -19.77589 -31.31322 4.72583   1.000 29.70069  ? 146  SER   A O    1 
ATOM   894  C  CB   . SER   A 1 141 ? -17.34811 -33.40849 5.30379   1.000 27.97367  ? 146  SER   A CB   1 
ATOM   895  O  OG   . SER   A 1 141 ? -18.47817 -34.17936 4.90470   1.000 27.60067  ? 146  SER   A OG   1 
ATOM   896  N  N    . GLY   A 1 142 ? -17.78679 -30.63336 3.88495   1.000 23.79111  ? 147  GLY   A N    1 
ATOM   897  C  CA   . GLY   A 1 142 ? -18.35368 -29.98923 2.71597   1.000 23.35574  ? 147  GLY   A CA   1 
ATOM   898  C  C    . GLY   A 1 142 ? -17.52567 -30.33324 1.49498   1.000 23.35138  ? 147  GLY   A C    1 
ATOM   899  O  O    . GLY   A 1 142 ? -16.31970 -30.56536 1.58401   1.000 23.55721  ? 147  GLY   A O    1 
ATOM   900  N  N    . SER   A 1 143 ? -18.18863 -30.35310 0.33795   1.000 23.92346  ? 148  SER   A N    1 
ATOM   901  C  CA   . SER   A 1 143 ? -17.59164 -30.96708 -0.84406  1.000 25.22744  ? 148  SER   A CA   1 
ATOM   902  C  C    . SER   A 1 143 ? -17.91552 -30.16597 -2.10003  1.000 25.12637  ? 148  SER   A C    1 
ATOM   903  O  O    . SER   A 1 143 ? -18.89144 -29.40587 -2.16902  1.000 25.00473  ? 148  SER   A O    1 
ATOM   904  C  CB   . SER   A 1 143 ? -18.06578 -32.42803 -0.98917  1.000 24.37815  ? 148  SER   A CB   1 
ATOM   905  O  OG   . SER   A 1 143 ? -17.77379 -32.99098 -2.25620  1.000 27.15203  ? 148  SER   A OG   1 
ATOM   906  N  N    . PHE   A 1 144 ? -17.04250 -30.34900 -3.09000  1.000 25.66402  ? 149  PHE   A N    1 
ATOM   907  C  CA   . PHE   A 1 144 ? -17.32341 -29.93988 -4.45799  1.000 26.33413  ? 149  PHE   A CA   1 
ATOM   908  C  C    . PHE   A 1 144 ? -18.67044 -30.50072 -4.92508  1.000 29.11942  ? 149  PHE   A C    1 
ATOM   909  O  O    . PHE   A 1 144 ? -19.35735 -29.88560 -5.76006  1.000 26.51061  ? 149  PHE   A O    1 
ATOM   910  C  CB   . PHE   A 1 144 ? -16.16942 -30.41594 -5.34698  1.000 25.23164  ? 149  PHE   A CB   1 
ATOM   911  C  CG   . PHE   A 1 144 ? -16.26632 -29.97684 -6.78795  1.000 25.66033  ? 149  PHE   A CG   1 
ATOM   912  C  CD1  . PHE   A 1 144 ? -15.70919 -28.76887 -7.19985  1.000 28.55812  ? 149  PHE   A CD1  1 
ATOM   913  C  CD2  . PHE   A 1 144 ? -16.87136 -30.78772 -7.73103  1.000 26.88732  ? 149  PHE   A CD2  1 
ATOM   914  C  CE1  . PHE   A 1 144 ? -15.77210 -28.35778 -8.52483  1.000 28.04298  ? 149  PHE   A CE1  1 
ATOM   915  C  CE2  . PHE   A 1 144 ? -16.94427 -30.39163 -9.07800  1.000 31.21308  ? 149  PHE   A CE2  1 
ATOM   916  C  CZ   . PHE   A 1 144 ? -16.39014 -29.17266 -9.46891  1.000 28.77708  ? 149  PHE   A CZ   1 
ATOM   917  N  N    . ASP   A 1 145 ? -19.09057 -31.63272 -4.36116  1.000 28.45254  ? 150  ASP   A N    1 
ATOM   918  C  CA   . ASP   A 1 145 ? -20.35062 -32.24257 -4.75925  1.000 27.73233  ? 150  ASP   A CA   1 
ATOM   919  C  C    . ASP   A 1 145 ? -21.56356 -31.48748 -4.24525  1.000 28.76658  ? 150  ASP   A C    1 
ATOM   920  O  O    . ASP   A 1 145 ? -22.68660 -31.92836 -4.49432  1.000 32.61964  ? 150  ASP   A O    1 
ATOM   921  C  CB   . ASP   A 1 145 ? -20.39278 -33.70959 -4.32234  1.000 29.63318  ? 150  ASP   A CB   1 
ATOM   922  C  CG   . ASP   A 1 145 ? -20.61685 -33.90166 -2.81636  1.000 30.80041  ? 150  ASP   A CG   1 
ATOM   923  O  OD1  . ASP   A 1 145 ? -20.96779 -32.94268 -2.06932  1.000 26.39564  ? 150  ASP   A OD1  1 
ATOM   924  O  OD2  . ASP   A 1 145 ? -20.43098 -35.05671 -2.38643  1.000 29.57702  ? 150  ASP   A OD2  1 
ATOM   925  N  N    . GLU   A 1 146 ? -21.37148 -30.35654 -3.56617  1.000 25.81374  ? 151  GLU   A N    1 
ATOM   926  C  CA   . GLU   A 1 146 ? -22.39540 -29.40147 -3.21815  1.000 28.10199  ? 151  GLU   A CA   1 
ATOM   927  C  C    . GLU   A 1 146 ? -23.15149 -29.85347 -1.97121  1.000 32.22758  ? 151  GLU   A C    1 
ATOM   928  O  O    . GLU   A 1 146 ? -24.10744 -29.18440 -1.56820  1.000 27.73927  ? 151  GLU   A O    1 
ATOM   929  C  CB   . GLU   A 1 146 ? -23.37233 -29.15030 -4.38617  1.000 28.80095  ? 151  GLU   A CB   1 
ATOM   930  C  CG   . GLU   A 1 146 ? -22.61427 -28.98429 -5.71513  1.000 27.44094  ? 151  GLU   A CG   1 
ATOM   931  C  CD   . GLU   A 1 146 ? -23.45317 -28.45713 -6.87113  1.000 32.16157  ? 151  GLU   A CD   1 
ATOM   932  O  OE1  . GLU   A 1 146 ? -24.68917 -28.40002 -6.75717  1.000 31.69146  ? 151  GLU   A OE1  1 
ATOM   933  O  OE2  . GLU   A 1 146 ? -22.85410 -28.10113 -7.90608  1.000 33.76591  ? 151  GLU   A OE2  1 
ATOM   934  N  N    . SER   A 1 147 ? -22.75262 -30.95255 -1.34026  1.000 26.56617  ? 152  SER   A N    1 
ATOM   935  C  CA   . SER   A 1 147 ? -23.42771 -31.41956 -0.14331  1.000 30.19273  ? 152  SER   A CA   1 
ATOM   936  C  C    . SER   A 1 147 ? -22.61773 -31.08772 1.10374   1.000 29.91743  ? 152  SER   A C    1 
ATOM   937  O  O    . SER   A 1 147 ? -21.41270 -30.81883 1.05380   1.000 28.16389  ? 152  SER   A O    1 
ATOM   938  C  CB   . SER   A 1 147 ? -23.68586 -32.92953 -0.19742  1.000 30.75038  ? 152  SER   A CB   1 
ATOM   939  O  OG   . SER   A 1 147 ? -22.49594 -33.65166 0.00358   1.000 27.79595  ? 152  SER   A OG   1 
ATOM   940  N  N    . VAL   A 1 148 ? -23.32677 -31.08772 2.22571   1.000 27.92021  ? 153  VAL   A N    1 
ATOM   941  C  CA   . VAL   A 1 148 ? -22.74882 -31.08386 3.55873   1.000 29.80187  ? 153  VAL   A CA   1 
ATOM   942  C  C    . VAL   A 1 148 ? -23.14997 -32.39586 4.20863   1.000 34.75871  ? 153  VAL   A C    1 
ATOM   943  O  O    . VAL   A 1 148 ? -24.33501 -32.76774 4.19257   1.000 31.14370  ? 153  VAL   A O    1 
ATOM   944  C  CB   . VAL   A 1 148 ? -23.23474 -29.88986 4.39379   1.000 28.22878  ? 153  VAL   A CB   1 
ATOM   945  C  CG1  . VAL   A 1 148 ? -22.82381 -30.06899 5.84379   1.000 29.10010  ? 153  VAL   A CG1  1 
ATOM   946  C  CG2  . VAL   A 1 148 ? -22.69059 -28.58388 3.81989   1.000 28.97403  ? 153  VAL   A CG2  1 
ATOM   947  N  N    . ARG   A 1 149 ? -22.16606 -33.10599 4.75363   1.000 30.05110  ? 154  ARG   A N    1 
ATOM   948  C  CA   . ARG   A 1 149 ? -22.39321 -34.39901 5.36554   1.000 30.41220  ? 154  ARG   A CA   1 
ATOM   949  C  C    . ARG   A 1 149 ? -22.02426 -34.35314 6.84155   1.000 31.65865  ? 154  ARG   A C    1 
ATOM   950  O  O    . ARG   A 1 149 ? -21.05921 -33.68625 7.23463   1.000 29.64400  ? 154  ARG   A O    1 
ATOM   951  C  CB   . ARG   A 1 149 ? -21.58829 -35.48604 4.65050   1.000 32.19856  ? 154  ARG   A CB   1 
ATOM   952  C  CG   . ARG   A 1 149 ? -22.23829 -35.98890 3.38544   1.000 33.72912  ? 154  ARG   A CG   1 
ATOM   953  C  CD   . ARG   A 1 149 ? -21.39938 -37.08994 2.77941   1.000 35.27286  ? 154  ARG   A CD   1 
ATOM   954  N  NE   . ARG   A 1 149 ? -22.23144 -38.05882 2.07731   1.000 43.71162  ? 154  ARG   A NE   1 
ATOM   955  C  CZ   . ARG   A 1 149 ? -22.71038 -37.86869 0.85531   1.000 45.20746  ? 154  ARG   A CZ   1 
ATOM   956  N  NH1  . ARG   A 1 149 ? -22.45924 -36.75267 0.18239   1.000 41.62677  ? 154  ARG   A NH1  1 
ATOM   957  N  NH2  . ARG   A 1 149 ? -23.45645 -38.81758 0.29522   1.000 43.57454  ? 154  ARG   A NH2  1 
ATOM   958  N  N    . ILE   A 1 150 ? -22.79237 -35.07711 7.65648   1.000 33.76188  ? 155  ILE   A N    1 
ATOM   959  C  CA   . ILE   A 1 150 ? -22.53843 -35.21523 9.08948   1.000 34.60700  ? 155  ILE   A CA   1 
ATOM   960  C  C    . ILE   A 1 150 ? -22.27059 -36.68827 9.35840   1.000 34.88448  ? 155  ILE   A C    1 
ATOM   961  O  O    . ILE   A 1 150 ? -23.06966 -37.55017 8.97031   1.000 36.52635  ? 155  ILE   A O    1 
ATOM   962  C  CB   . ILE   A 1 150 ? -23.71942 -34.70317 9.93847   1.000 33.07421  ? 155  ILE   A CB   1 
ATOM   963  C  CG1  . ILE   A 1 150 ? -24.05226 -33.25111 9.57755   1.000 35.81895  ? 155  ILE   A CG1  1 
ATOM   964  C  CG2  . ILE   A 1 150 ? -23.41449 -34.85029 11.43347  1.000 36.91230  ? 155  ILE   A CG2  1 
ATOM   965  C  CD1  . ILE   A 1 150 ? -25.38124 -32.75302 10.18053  1.000 37.18426  ? 155  ILE   A CD1  1 
ATOM   966  N  N    . TRP   A 1 151 ? -21.14164 -36.97542 10.00242  1.000 34.09150  ? 156  TRP   A N    1 
ATOM   967  C  CA   . TRP   A 1 151 ? -20.62377 -38.33148 10.10736  1.000 34.16871  ? 156  TRP   A CA   1 
ATOM   968  C  C    . TRP   A 1 151 ? -20.55487 -38.75158 11.56633  1.000 37.69499  ? 156  TRP   A C    1 
ATOM   969  O  O    . TRP   A 1 151 ? -20.32482 -37.92365 12.45539  1.000 29.59853  ? 156  TRP   A O    1 
ATOM   970  C  CB   . TRP   A 1 151 ? -19.21676 -38.44358 9.51340   1.000 33.30652  ? 156  TRP   A CB   1 
ATOM   971  C  CG   . TRP   A 1 151 ? -19.09166 -37.91150 8.12144   1.000 32.40392  ? 156  TRP   A CG   1 
ATOM   972  C  CD1  . TRP   A 1 151 ? -18.97652 -36.59449 7.74353   1.000 32.43143  ? 156  TRP   A CD1  1 
ATOM   973  C  CD2  . TRP   A 1 151 ? -19.03869 -38.68243 6.91440   1.000 33.35825  ? 156  TRP   A CD2  1 
ATOM   974  N  NE1  . TRP   A 1 151 ? -18.86046 -36.50641 6.37554   1.000 31.69437  ? 156  TRP   A NE1  1 
ATOM   975  C  CE2  . TRP   A 1 151 ? -18.89656 -37.76838 5.84146   1.000 34.42574  ? 156  TRP   A CE2  1 
ATOM   976  C  CE3  . TRP   A 1 151 ? -19.11581 -40.05041 6.63431   1.000 33.38175  ? 156  TRP   A CE3  1 
ATOM   977  C  CZ2  . TRP   A 1 151 ? -18.82255 -38.18730 4.50743   1.000 35.08860  ? 156  TRP   A CZ2  1 
ATOM   978  C  CZ3  . TRP   A 1 151 ? -19.03280 -40.47233 5.30728   1.000 40.18622  ? 156  TRP   A CZ3  1 
ATOM   979  C  CH2  . TRP   A 1 151 ? -18.88767 -39.54028 4.25635   1.000 39.02974  ? 156  TRP   A CH2  1 
ATOM   980  N  N    . ASP   A 1 152 ? -20.71401 -40.05457 11.79225  1.000 36.70087  ? 157  ASP   A N    1 
ATOM   981  C  CA   . ASP   A 1 152 ? -20.51011 -40.63668 13.11822  1.000 38.97729  ? 157  ASP   A CA   1 
ATOM   982  C  C    . ASP   A 1 152 ? -19.01615 -40.91184 13.32526  1.000 32.06926  ? 157  ASP   A C    1 
ATOM   983  O  O    . ASP   A 1 152 ? -18.44821 -41.81185 12.69822  1.000 36.48377  ? 157  ASP   A O    1 
ATOM   984  C  CB   . ASP   A 1 152 ? -21.34924 -41.90561 13.27311  1.000 38.02879  ? 157  ASP   A CB   1 
ATOM   985  C  CG   . ASP   A 1 152 ? -21.46034 -42.35669 14.72307  1.000 43.70018  ? 157  ASP   A CG   1 
ATOM   986  O  OD1  . ASP   A 1 152 ? -20.44236 -42.26283 15.45612  1.000 38.06821  ? 157  ASP   A OD1  1 
ATOM   987  O  OD2  . ASP   A 1 152 ? -22.57040 -42.78360 15.13100  1.000 41.45469  ? 157  ASP   A OD2  1 
ATOM   988  N  N    . VAL   A 1 153 ? -18.39110 -40.12395 14.20333  1.000 29.32889  ? 158  VAL   A N    1 
ATOM   989  C  CA   . VAL   A 1 153 ? -16.97013 -40.24711 14.52038  1.000 36.46547  ? 158  VAL   A CA   1 
ATOM   990  C  C    . VAL   A 1 153 ? -16.61028 -41.68117 14.87030  1.000 41.66663  ? 158  VAL   A C    1 
ATOM   991  O  O    . VAL   A 1 153 ? -15.58731 -42.20624 14.40831  1.000 42.84926  ? 158  VAL   A O    1 
ATOM   992  C  CB   . VAL   A 1 153 ? -16.60108 -39.28922 15.67345  1.000 35.48899  ? 158  VAL   A CB   1 
ATOM   993  C  CG1  . VAL   A 1 153 ? -15.24114 -39.64839 16.25448  1.000 34.69906  ? 158  VAL   A CG1  1 
ATOM   994  C  CG2  . VAL   A 1 153 ? -16.62592 -37.82019 15.20954  1.000 35.08222  ? 158  VAL   A CG2  1 
ATOM   995  N  N    . LYS   A 1 154 ? -17.41837 -42.29914 15.73123  1.000 35.30403  ? 159  LYS   A N    1 
ATOM   996  C  CA   . LYS   A 1 154 ? -17.07752 -43.64221 16.26216  1.000 35.91852  ? 159  LYS   A CA   1 
ATOM   997  C  C    . LYS   A 1 154 ? -17.35759 -44.74812 15.23808  1.000 40.52430  ? 159  LYS   A C    1 
ATOM   998  O  O    . LYS   A 1 154 ? -16.55168 -45.67819 15.16905  1.000 47.27785  ? 159  LYS   A O    1 
ATOM   999  C  CB   . LYS   A 1 154 ? -17.83959 -43.82422 17.57712  1.000 38.86768  ? 159  LYS   A CB   1 
ATOM   1000 C  CG   . LYS   A 1 154 ? -17.21857 -43.12835 18.77019  1.000 39.15476  ? 159  LYS   A CG   1 
ATOM   1001 C  CD   . LYS   A 1 154 ? -15.86464 -43.73051 19.12120  1.000 49.35767  ? 159  LYS   A CD   1 
ATOM   1002 C  CE   . LYS   A 1 154 ? -15.08059 -42.87864 20.06128  1.000 49.81351  ? 159  LYS   A CE   1 
ATOM   1003 N  NZ   . LYS   A 1 154 ? -13.71765 -43.39078 20.21530  1.000 57.27204  ? 159  LYS   A NZ   1 
ATOM   1004 N  N    . THR   A 1 155 ? -18.45856 -44.65996 14.50704  1.000 33.76292  ? 160  THR   A N    1 
ATOM   1005 C  CA   . THR   A 1 155 ? -18.75962 -45.66787 13.50797  1.000 41.64775  ? 160  THR   A CA   1 
ATOM   1006 C  C    . THR   A 1 155 ? -18.18153 -45.32284 12.14601  1.000 40.29273  ? 160  THR   A C    1 
ATOM   1007 O  O    . THR   A 1 155 ? -18.03959 -46.22180 11.30796  1.000 47.29829  ? 160  THR   A O    1 
ATOM   1008 C  CB   . THR   A 1 155 ? -20.27463 -45.85372 13.37990  1.000 44.29475  ? 160  THR   A CB   1 
ATOM   1009 O  OG1  . THR   A 1 155 ? -20.84649 -44.71162 12.71595  1.000 44.13882  ? 160  THR   A OG1  1 
ATOM   1010 C  CG2  . THR   A 1 155 ? -20.90570 -46.00374 14.75586  1.000 42.04040  ? 160  THR   A CG2  1 
ATOM   1011 N  N    . GLY   A 1 156 ? -17.84640 -44.04886 11.91110  1.000 41.78928  ? 161  GLY   A N    1 
ATOM   1012 C  CA   . GLY   A 1 156 ? -17.39531 -43.61982 10.59815  1.000 42.99345  ? 161  GLY   A CA   1 
ATOM   1013 C  C    . GLY   A 1 156 ? -18.48927 -43.60765 9.56211   1.000 41.36520  ? 161  GLY   A C    1 
ATOM   1014 O  O    . GLY   A 1 156 ? -18.20521 -43.53560 8.36512   1.000 44.62441  ? 161  GLY   A O    1 
ATOM   1015 N  N    . LYS   A 1 157 ? -19.74029 -43.67256 9.99506   1.000 38.79233  ? 162  LYS   A N    1 
ATOM   1016 C  CA   . LYS   A 1 157 ? -20.87726 -43.71439 9.09001   1.000 46.83989  ? 162  LYS   A CA   1 
ATOM   1017 C  C    . LYS   A 1 157 ? -21.44212 -42.31332 8.88608   1.000 43.24356  ? 162  LYS   A C    1 
ATOM   1018 O  O    . LYS   A 1 157 ? -21.42907 -41.47338 9.79613   1.000 35.11507  ? 162  LYS   A O    1 
ATOM   1019 C  CB   . LYS   A 1 157 ? -21.97037 -44.65532 9.62791   1.000 46.96189  ? 162  LYS   A CB   1 
ATOM   1020 C  CG   . LYS   A 1 157 ? -21.54352 -46.13836 9.63783   1.000 53.92142  ? 162  LYS   A CG   1 
ATOM   1021 C  CD   . LYS   A 1 157 ? -22.64163 -47.08428 10.14473  1.000 62.07700  ? 162  LYS   A CD   1 
ATOM   1022 C  CE   . LYS   A 1 157 ? -22.35173 -47.59040 11.57271  1.000 63.86042  ? 162  LYS   A CE   1 
ATOM   1023 N  NZ   . LYS   A 1 157 ? -23.07487 -48.85335 11.93460  1.000 62.79485  ? 162  LYS   A NZ   1 
ATOM   1024 N  N    . CYS   A 1 158 ? -21.93605 -42.06920 7.67507   1.000 32.93683  ? 163  CYS   A N    1 
ATOM   1025 C  CA   . CYS   A 1 158 ? -22.60891 -40.81011 7.40213   1.000 35.16490  ? 163  CYS   A CA   1 
ATOM   1026 C  C    . CYS   A 1 158 ? -23.99694 -40.83102 8.05007   1.000 37.77574  ? 163  CYS   A C    1 
ATOM   1027 O  O    . CYS   A 1 158 ? -24.84601 -41.65392 7.69799   1.000 38.88076  ? 163  CYS   A O    1 
ATOM   1028 C  CB   . CYS   A 1 158 ? -22.70383 -40.58101 5.89314   1.000 35.30624  ? 163  CYS   A CB   1 
ATOM   1029 S  SG   . CYS   A 1 158 ? -23.48566 -39.01091 5.43621   1.000 37.40273  ? 163  CYS   A SG   1 
ATOM   1030 N  N    . LEU   A 1 159 ? -24.22789 -39.94106 9.01012   1.000 35.25664  ? 164  LEU   A N    1 
ATOM   1031 C  CA   . LEU   A 1 159 ? -25.55291 -39.86797 9.62007   1.000 35.94442  ? 164  LEU   A CA   1 
ATOM   1032 C  C    . LEU   A 1 159 ? -26.53380 -39.10582 8.73708   1.000 44.34037  ? 164  LEU   A C    1 
ATOM   1033 O  O    . LEU   A 1 159 ? -27.70083 -39.50370 8.62301   1.000 36.31638  ? 164  LEU   A O    1 
ATOM   1034 C  CB   . LEU   A 1 159 ? -25.46989 -39.21106 10.99712  1.000 32.73832  ? 164  LEU   A CB   1 
ATOM   1035 C  CG   . LEU   A 1 159 ? -24.70201 -39.97420 12.08110  1.000 40.41649  ? 164  LEU   A CG   1 
ATOM   1036 C  CD1  . LEU   A 1 159 ? -24.53098 -39.12630 13.34316  1.000 37.15052  ? 164  LEU   A CD1  1 
ATOM   1037 C  CD2  . LEU   A 1 159 ? -25.40515 -41.29416 12.40199  1.000 43.26207  ? 164  LEU   A CD2  1 
ATOM   1038 N  N    . LYS   A 1 160 ? -26.08267 -38.01482 8.10617   1.000 34.57293  ? 165  LYS   A N    1 
ATOM   1039 C  CA   . LYS   A 1 160 ? -26.95155 -37.16169 7.30519   1.000 40.13766  ? 165  LYS   A CA   1 
ATOM   1040 C  C    . LYS   A 1 160 ? -26.20046 -36.62968 6.09425   1.000 43.07443  ? 165  LYS   A C    1 
ATOM   1041 O  O    . LYS   A 1 160 ? -25.01243 -36.29380 6.18132   1.000 38.89333  ? 165  LYS   A O    1 
ATOM   1042 C  CB   . LYS   A 1 160 ? -27.50347 -35.98668 8.13124   1.000 43.35273  ? 165  LYS   A CB   1 
ATOM   1043 C  CG   . LYS   A 1 160 ? -28.44956 -36.41266 9.24218   1.000 47.43626  ? 165  LYS   A CG   1 
ATOM   1044 C  CD   . LYS   A 1 160 ? -29.72747 -35.59254 9.21718   1.000 53.87435  ? 165  LYS   A CD   1 
ATOM   1045 C  CE   . LYS   A 1 160 ? -29.64240 -34.40961 10.18726  1.000 50.10009  ? 165  LYS   A CE   1 
ATOM   1046 N  NZ   . LYS   A 1 160 ? -29.64850 -34.86669 11.61823  1.000 51.87279  ? 165  LYS   A NZ   1 
ATOM   1047 N  N    . THR   A 1 161 ? -26.89741 -36.56154 4.96223   1.000 34.06260  ? 166  THR   A N    1 
ATOM   1048 C  CA   . THR   A 1 161 ? -26.41029 -35.85852 3.78329   1.000 35.26805  ? 166  THR   A CA   1 
ATOM   1049 C  C    . THR   A 1 161 ? -27.33017 -34.65941 3.57833   1.000 42.84143  ? 166  THR   A C    1 
ATOM   1050 O  O    . THR   A 1 161 ? -28.52918 -34.82228 3.32428   1.000 43.85856  ? 166  THR   A O    1 
ATOM   1051 C  CB   . THR   A 1 161 ? -26.39034 -36.76944 2.55924   1.000 36.87385  ? 166  THR   A CB   1 
ATOM   1052 O  OG1  . THR   A 1 161 ? -25.55146 -37.90654 2.82220   1.000 38.09942  ? 166  THR   A OG1  1 
ATOM   1053 C  CG2  . THR   A 1 161 ? -25.87422 -36.01341 1.33030   1.000 36.16096  ? 166  THR   A CG2  1 
ATOM   1054 N  N    . LEU   A 1 162 ? -26.78406 -33.46048 3.71843   1.000 37.57125  ? 167  LEU   A N    1 
ATOM   1055 C  CA   . LEU   A 1 162 ? -27.63194 -32.29038 3.49047   1.000 35.87231  ? 167  LEU   A CA   1 
ATOM   1056 C  C    . LEU   A 1 162 ? -27.48483 -31.80230 2.04851   1.000 35.47747  ? 167  LEU   A C    1 
ATOM   1057 O  O    . LEU   A 1 162 ? -26.36080 -31.60838 1.57956   1.000 36.31733  ? 167  LEU   A O    1 
ATOM   1058 C  CB   . LEU   A 1 162 ? -27.27586 -31.15847 4.44056   1.000 32.28126  ? 167  LEU   A CB   1 
ATOM   1059 C  CG   . LEU   A 1 162 ? -27.03295 -31.52759 5.90954   1.000 35.63994  ? 167  LEU   A CG   1 
ATOM   1060 C  CD1  . LEU   A 1 162 ? -26.63286 -30.28468 6.69164   1.000 31.59271  ? 167  LEU   A CD1  1 
ATOM   1061 C  CD2  . LEU   A 1 162 ? -28.27804 -32.15851 6.52245   1.000 37.59588  ? 167  LEU   A CD2  1 
ATOM   1062 N  N    . PRO   A 1 163 ? -28.57979 -31.59415 1.31748   1.000 38.72204  ? 168  PRO   A N    1 
ATOM   1063 C  CA   . PRO   A 1 163 ? -28.46667 -30.96608 -0.01148  1.000 38.55214  ? 168  PRO   A CA   1 
ATOM   1064 C  C    . PRO   A 1 163 ? -28.25654 -29.46711 0.17262   1.000 37.32549  ? 168  PRO   A C    1 
ATOM   1065 O  O    . PRO   A 1 163 ? -29.15445 -28.62801 -0.03336  1.000 34.85012  ? 168  PRO   A O    1 
ATOM   1066 C  CB   . PRO   A 1 163 ? -29.81168 -31.31191 -0.65155  1.000 44.63114  ? 168  PRO   A CB   1 
ATOM   1067 C  CG   . PRO   A 1 163 ? -30.77372 -31.18489 0.52642   1.000 41.66111  ? 168  PRO   A CG   1 
ATOM   1068 C  CD   . PRO   A 1 163 ? -29.98981 -31.72104 1.73342   1.000 37.90643  ? 168  PRO   A CD   1 
ATOM   1069 N  N    . ALA   A 1 164 ? -27.04352 -29.11126 0.60769   1.000 31.70333  ? 169  ALA   A N    1 
ATOM   1070 C  CA   . ALA   A 1 164 ? -26.85742 -27.82831 1.25878   1.000 30.57741  ? 169  ALA   A CA   1 
ATOM   1071 C  C    . ALA   A 1 164 ? -26.91527 -26.67925 0.26485   1.000 29.08407  ? 169  ALA   A C    1 
ATOM   1072 O  O    . ALA   A 1 164 ? -27.44818 -25.60721 0.58190   1.000 27.96366  ? 169  ALA   A O    1 
ATOM   1073 C  CB   . ALA   A 1 164 ? -25.52745 -27.81849 2.01683   1.000 28.71027  ? 169  ALA   A CB   1 
ATOM   1074 N  N    . HIS   A 1 165 ? -26.36424 -26.87522 -0.92914  1.000 28.49113  ? 170  HIS   A N    1 
ATOM   1075 C  CA   . HIS   A 1 165 ? -26.06710 -25.75220 -1.80106  1.000 30.88681  ? 170  HIS   A CA   1 
ATOM   1076 C  C    . HIS   A 1 165 ? -26.20209 -26.19309 -3.25009  1.000 26.47087  ? 170  HIS   A C    1 
ATOM   1077 O  O    . HIS   A 1 165 ? -26.28219 -27.38207 -3.54817  1.000 26.86857  ? 170  HIS   A O    1 
ATOM   1078 C  CB   . HIS   A 1 165 ? -24.65906 -25.20435 -1.51897  1.000 24.81229  ? 170  HIS   A CB   1 
ATOM   1079 C  CG   . HIS   A 1 165 ? -24.53604 -24.48245 -0.20992  1.000 22.74570  ? 170  HIS   A CG   1 
ATOM   1080 N  ND1  . HIS   A 1 165 ? -24.96092 -23.17742 -0.03185  1.000 25.66741  ? 170  HIS   A ND1  1 
ATOM   1081 C  CD2  . HIS   A 1 165 ? -24.00812 -24.87057 0.97908   1.000 25.59034  ? 170  HIS   A CD2  1 
ATOM   1082 C  CE1  . HIS   A 1 165 ? -24.69893 -22.79852 1.21118   1.000 25.37070  ? 170  HIS   A CE1  1 
ATOM   1083 N  NE2  . HIS   A 1 165 ? -24.11805 -23.80662 1.84214   1.000 25.63211  ? 170  HIS   A NE2  1 
ATOM   1084 N  N    . SER   A 1 166 ? -26.19596 -25.21604 -4.15903  1.000 26.86327  ? 171  SER   A N    1 
ATOM   1085 C  CA   . SER   A 1 166 ? -26.24993 -25.49794 -5.59305  1.000 24.95680  ? 171  SER   A CA   1 
ATOM   1086 C  C    . SER   A 1 166 ? -24.90588 -25.26803 -6.28998  1.000 27.15751  ? 171  SER   A C    1 
ATOM   1087 O  O    . SER   A 1 166 ? -24.86283 -25.22796 -7.52698  1.000 26.96907  ? 171  SER   A O    1 
ATOM   1088 C  CB   . SER   A 1 166 ? -27.34782 -24.65679 -6.24804  1.000 28.24346  ? 171  SER   A CB   1 
ATOM   1089 O  OG   . SER   A 1 166 ? -27.17370 -23.27383 -5.96894  1.000 27.15719  ? 171  SER   A OG   1 
ATOM   1090 N  N    . ASP   A 1 167 ? -23.82190 -25.13118 -5.52793  1.000 25.73665  ? 172  ASP   A N    1 
ATOM   1091 C  CA   . ASP   A 1 167 ? -22.45987 -25.03728 -6.04288  1.000 28.02752  ? 172  ASP   A CA   1 
ATOM   1092 C  C    . ASP   A 1 167 ? -21.52896 -25.59544 -4.98388  1.000 23.18771  ? 172  ASP   A C    1 
ATOM   1093 O  O    . ASP   A 1 167 ? -21.95303 -25.85247 -3.84991  1.000 25.85627  ? 172  ASP   A O    1 
ATOM   1094 C  CB   . ASP   A 1 167 ? -22.07372 -23.58830 -6.38177  1.000 24.97787  ? 172  ASP   A CB   1 
ATOM   1095 C  CG   . ASP   A 1 167 ? -22.64662 -23.11716 -7.70576  1.000 27.00780  ? 172  ASP   A CG   1 
ATOM   1096 O  OD1  . ASP   A 1 167 ? -22.46965 -23.81511 -8.72280  1.000 34.34956  ? 172  ASP   A OD1  1 
ATOM   1097 O  OD2  . ASP   A 1 167 ? -23.28052 -22.05410 -7.72572  1.000 30.90378  ? 172  ASP   A OD2  1 
ATOM   1098 N  N    . PRO   A 1 168 ? -20.24797 -25.79254 -5.30384  1.000 28.39684  ? 173  PRO   A N    1 
ATOM   1099 C  CA   . PRO   A 1 168 ? -19.31707 -26.38370 -4.32684  1.000 24.51472  ? 173  PRO   A CA   1 
ATOM   1100 C  C    . PRO   A 1 168 ? -19.34605 -25.69078 -2.96180  1.000 25.67995  ? 173  PRO   A C    1 
ATOM   1101 O  O    . PRO   A 1 168 ? -19.55994 -24.47877 -2.85073  1.000 22.26892  ? 173  PRO   A O    1 
ATOM   1102 C  CB   . PRO   A 1 168 ? -17.94602 -26.22979 -5.00378  1.000 24.36670  ? 173  PRO   A CB   1 
ATOM   1103 C  CG   . PRO   A 1 168 ? -18.27598 -26.31566 -6.51580  1.000 22.50888  ? 173  PRO   A CG   1 
ATOM   1104 C  CD   . PRO   A 1 168 ? -19.62790 -25.60152 -6.63580  1.000 24.56308  ? 173  PRO   A CD   1 
ATOM   1105 N  N    . VAL   A 1 169 ? -19.11517 -26.47787 -1.90884  1.000 25.74409  ? 174  VAL   A N    1 
ATOM   1106 C  CA   . VAL   A 1 169 ? -19.12317 -25.98195 -0.52681  1.000 24.45477  ? 174  VAL   A CA   1 
ATOM   1107 C  C    . VAL   A 1 169 ? -17.69116 -25.67312 -0.09974  1.000 25.91064  ? 174  VAL   A C    1 
ATOM   1108 O  O    . VAL   A 1 169 ? -16.79723 -26.52520 -0.22175  1.000 24.85498  ? 174  VAL   A O    1 
ATOM   1109 C  CB   . VAL   A 1 169 ? -19.77431 -27.00195 0.42810   1.000 24.00942  ? 174  VAL   A CB   1 
ATOM   1110 C  CG1  . VAL   A 1 169 ? -19.91530 -26.40903 1.83213   1.000 26.19004  ? 174  VAL   A CG1  1 
ATOM   1111 C  CG2  . VAL   A 1 169 ? -21.13233 -27.42079 -0.10498  1.000 24.87824  ? 174  VAL   A CG2  1 
ATOM   1112 N  N    . SER   A 1 170 ? -17.47206 -24.46517 0.42435   1.000 22.79147  ? 175  SER   A N    1 
ATOM   1113 C  CA   . SER   A 1 170 ? -16.11402 -24.00432 0.70043   1.000 24.83217  ? 175  SER   A CA   1 
ATOM   1114 C  C    . SER   A 1 170 ? -15.71409 -24.07046 2.18144   1.000 24.36720  ? 175  SER   A C    1 
ATOM   1115 O  O    . SER   A 1 170 ? -14.50510 -24.06959 2.49549   1.000 23.84984  ? 175  SER   A O    1 
ATOM   1116 C  CB   . SER   A 1 170 ? -15.95587 -22.56331 0.19253   1.000 25.07663  ? 175  SER   A CB   1 
ATOM   1117 O  OG   . SER   A 1 170 ? -16.94780 -21.69025 0.74854   1.000 21.71957  ? 175  SER   A OG   1 
ATOM   1118 N  N    . ALA   A 1 171 ? -16.68213 -24.12842 3.09640   1.000 23.36664  ? 176  ALA   A N    1 
ATOM   1119 C  CA   . ALA   A 1 171 ? -16.38318 -24.15654 4.52341   1.000 26.27477  ? 176  ALA   A CA   1 
ATOM   1120 C  C    . ALA   A 1 171 ? -17.58727 -24.70047 5.29233   1.000 28.00523  ? 176  ALA   A C    1 
ATOM   1121 O  O    . ALA   A 1 171 ? -18.73724 -24.55733 4.86130   1.000 24.85995  ? 176  ALA   A O    1 
ATOM   1122 C  CB   . ALA   A 1 171 ? -16.00007 -22.76461 5.04451   1.000 21.24483  ? 176  ALA   A CB   1 
ATOM   1123 N  N    . VAL   A 1 172 ? -17.30037 -25.33357 6.43030   1.000 24.76474  ? 177  VAL   A N    1 
ATOM   1124 C  CA   . VAL   A 1 172 ? -18.33145 -25.83653 7.33323   1.000 26.99397  ? 177  VAL   A CA   1 
ATOM   1125 C  C    . VAL   A 1 172 ? -17.78450 -25.71867 8.74226   1.000 30.07256  ? 177  VAL   A C    1 
ATOM   1126 O  O    . VAL   A 1 172 ? -16.58452 -25.87480 8.97229   1.000 27.31996  ? 177  VAL   A O    1 
ATOM   1127 C  CB   . VAL   A 1 172 ? -18.73658 -27.29247 7.02412   1.000 26.13311  ? 177  VAL   A CB   1 
ATOM   1128 C  CG1  . VAL   A 1 172 ? -19.46054 -27.37131 5.67109   1.000 25.09208  ? 177  VAL   A CG1  1 
ATOM   1129 C  CG2  . VAL   A 1 172 ? -17.50868 -28.21759 7.06311   1.000 25.54551  ? 177  VAL   A CG2  1 
ATOM   1130 N  N    . HIS   A 1 173 ? -18.66750 -25.42364 9.68724   1.000 27.61513  ? 178  HIS   A N    1 
ATOM   1131 C  CA   . HIS   A 1 173 ? -18.23552 -25.09877 11.04528  1.000 32.27844  ? 178  HIS   A CA   1 
ATOM   1132 C  C    . HIS   A 1 173 ? -19.41658 -25.27271 11.99622  1.000 33.11710  ? 178  HIS   A C    1 
ATOM   1133 O  O    . HIS   A 1 173 ? -20.53152 -24.81359 11.69621  1.000 30.47157  ? 178  HIS   A O    1 
ATOM   1134 C  CB   . HIS   A 1 173 ? -17.69139 -23.66683 11.12139  1.000 28.09475  ? 178  HIS   A CB   1 
ATOM   1135 C  CG   . HIS   A 1 173 ? -17.01740 -23.32997 12.42044  1.000 34.77604  ? 178  HIS   A CG   1 
ATOM   1136 N  ND1  . HIS   A 1 173 ? -17.28532 -22.16899 13.11950  1.000 33.71151  ? 178  HIS   A ND1  1 
ATOM   1137 C  CD2  . HIS   A 1 173 ? -16.07350 -23.99011 13.13943  1.000 33.91537  ? 178  HIS   A CD2  1 
ATOM   1138 C  CE1  . HIS   A 1 173 ? -16.54336 -22.13213 14.21453  1.000 34.07527  ? 178  HIS   A CE1  1 
ATOM   1139 N  NE2  . HIS   A 1 173 ? -15.80246 -23.22421 14.25049  1.000 34.52976  ? 178  HIS   A NE2  1 
ATOM   1140 N  N    . PHE   A 1 174 ? -19.17469 -25.95281 13.12019  1.000 30.81930  ? 179  PHE   A N    1 
ATOM   1141 C  CA   . PHE   A 1 174 ? -20.12673 -26.00378 14.22915  1.000 35.02534  ? 179  PHE   A CA   1 
ATOM   1142 C  C    . PHE   A 1 174 ? -20.01764 -24.73985 15.07424  1.000 35.37814  ? 179  PHE   A C    1 
ATOM   1143 O  O    . PHE   A 1 174 ? -18.93659 -24.15296 15.21131  1.000 31.34814  ? 179  PHE   A O    1 
ATOM   1144 C  CB   . PHE   A 1 174 ? -19.87189 -27.22087 15.13008  1.000 30.70848  ? 179  PHE   A CB   1 
ATOM   1145 C  CG   . PHE   A 1 174 ? -20.31199 -28.54079 14.53298  1.000 31.90431  ? 179  PHE   A CG   1 
ATOM   1146 C  CD1  . PHE   A 1 174 ? -21.64103 -28.93666 14.59791  1.000 26.97382  ? 179  PHE   A CD1  1 
ATOM   1147 C  CD2  . PHE   A 1 174 ? -19.38805 -29.38584 13.94397  1.000 26.93339  ? 179  PHE   A CD2  1 
ATOM   1148 C  CE1  . PHE   A 1 174 ? -22.04413 -30.15759 14.07782  1.000 31.38390  ? 179  PHE   A CE1  1 
ATOM   1149 C  CE2  . PHE   A 1 174 ? -19.77315 -30.60677 13.40688  1.000 32.61552  ? 179  PHE   A CE2  1 
ATOM   1150 C  CZ   . PHE   A 1 174 ? -21.11019 -30.99864 13.46780  1.000 29.70282  ? 179  PHE   A CZ   1 
ATOM   1151 N  N    . ASN   A 1 175 ? -21.15262 -24.32177 15.64522  1.000 29.52191  ? 180  ASN   A N    1 
ATOM   1152 C  CA   . ASN   A 1 175 ? -21.15056 -23.25284 16.63229  1.000 33.30756  ? 180  ASN   A CA   1 
ATOM   1153 C  C    . ASN   A 1 175 ? -20.70066 -23.81596 17.98627  1.000 37.97311  ? 180  ASN   A C    1 
ATOM   1154 O  O    . ASN   A 1 175 ? -20.50479 -25.02399 18.14720  1.000 31.94217  ? 180  ASN   A O    1 
ATOM   1155 C  CB   . ASN   A 1 175 ? -22.52250 -22.59071 16.72528  1.000 35.96988  ? 180  ASN   A CB   1 
ATOM   1156 C  CG   . ASN   A 1 175 ? -23.56161 -23.46765 17.44418  1.000 35.38769  ? 180  ASN   A CG   1 
ATOM   1157 O  OD1  . ASN   A 1 175 ? -23.46873 -24.70066 17.44911  1.000 33.43392  ? 180  ASN   A OD1  1 
ATOM   1158 N  ND2  . ASN   A 1 175 ? -24.56857 -22.82259 18.03818  1.000 34.72681  ? 180  ASN   A ND2  1 
ATOM   1159 N  N    . ARG   A 1 176 ? -20.47561 -22.92005 18.95533  1.000 39.07822  ? 181  ARG   A N    1 
ATOM   1160 C  CA   . ARG   A 1 176 ? -19.85770 -23.27319 20.26833  1.000 43.57815  ? 181  ARG   A CA   1 
ATOM   1161 C  C    . ARG   A 1 176 ? -20.52084 -24.45117 20.99323  1.000 43.56795  ? 181  ARG   A C    1 
ATOM   1162 O  O    . ARG   A 1 176 ? -19.81794 -25.18728 21.68521  1.000 41.90293  ? 181  ARG   A O    1 
ATOM   1163 C  CB   . ARG   A 1 176 ? -19.87961 -22.04025 21.17541  1.000 38.29872  ? 181  ARG   A CB   1 
ATOM   1164 C  CG   . ARG   A 1 176 ? -21.20454 -21.29512 21.21341  1.000 51.85858  ? 181  ARG   A CG   1 
ATOM   1165 C  CD   . ARG   A 1 176 ? -21.37251 -20.47518 22.48245  1.000 61.28444  ? 181  ARG   A CD   1 
ATOM   1166 N  NE   . ARG   A 1 176 ? -20.26056 -20.64635 23.42248  1.000 61.74076  ? 181  ARG   A NE   1 
ATOM   1167 C  CZ   . ARG   A 1 176 ? -19.57348 -19.64945 23.96157  1.000 72.57393  ? 181  ARG   A CZ   1 
ATOM   1168 N  NH1  . ARG   A 1 176 ? -20.19840 -18.56742 24.38862  1.000 64.82857  ? 181  ARG   A NH1  1 
ATOM   1169 N  NH2  . ARG   A 1 176 ? -18.25950 -19.73859 24.07462  1.000 69.62207  ? 181  ARG   A NH2  1 
ATOM   1170 N  N    . ASP   A 1 177 ? -21.82985 -24.56704 20.88318  1.000 36.78648  ? 182  ASP   A N    1 
ATOM   1171 C  CA   . ASP   A 1 177 ? -22.50398 -25.65302 21.59408  1.000 36.85705  ? 182  ASP   A CA   1 
ATOM   1172 C  C    . ASP   A 1 177 ? -22.92205 -26.78892 20.67000  1.000 39.12499  ? 182  ASP   A C    1 
ATOM   1173 O  O    . ASP   A 1 177 ? -23.62016 -27.71588 21.11191  1.000 36.83788  ? 182  ASP   A O    1 
ATOM   1174 C  CB   . ASP   A 1 177 ? -23.71296 -25.13195 22.39107  1.000 39.99731  ? 182  ASP   A CB   1 
ATOM   1175 C  CG   . ASP   A 1 177 ? -24.84787 -24.59378 21.50006  1.000 44.85797  ? 182  ASP   A CG   1 
ATOM   1176 O  OD1  . ASP   A 1 177 ? -24.86385 -24.84470 20.26804  1.000 43.39559  ? 182  ASP   A OD1  1 
ATOM   1177 O  OD2  . ASP   A 1 177 ? -25.74383 -23.91073 22.05007  1.000 44.42571  ? 182  ASP   A OD2  1 
ATOM   1178 N  N    . GLY   A 1 178 ? -22.52300 -26.73688 19.39001  1.000 37.62812  ? 183  GLY   A N    1 
ATOM   1179 C  CA   . GLY   A 1 178 ? -22.74307 -27.81880 18.45594  1.000 32.02279  ? 183  GLY   A CA   1 
ATOM   1180 C  C    . GLY   A 1 178 ? -24.15807 -27.97063 17.94987  1.000 30.67925  ? 183  GLY   A C    1 
ATOM   1181 O  O    . GLY   A 1 178 ? -24.42113 -28.90755 17.18581  1.000 31.97911  ? 183  GLY   A O    1 
ATOM   1182 N  N    . SER   A 1 179 ? -25.08500 -27.09256 18.34789  1.000 35.31613  ? 184  SER   A N    1 
ATOM   1183 C  CA   . SER   A 1 179 ? -26.46399 -27.20140 17.87384  1.000 37.73674  ? 184  SER   A CA   1 
ATOM   1184 C  C    . SER   A 1 179 ? -26.63488 -26.66229 16.45986  1.000 35.16578  ? 184  SER   A C    1 
ATOM   1185 O  O    . SER   A 1 179 ? -27.63989 -26.97915 15.80580  1.000 34.11982  ? 184  SER   A O    1 
ATOM   1186 C  CB   . SER   A 1 179 ? -27.41995 -26.45736 18.81885  1.000 33.78357  ? 184  SER   A CB   1 
ATOM   1187 O  OG   . SER   A 1 179 ? -27.05882 -25.08841 18.92995  1.000 37.03587  ? 184  SER   A OG   1 
ATOM   1188 N  N    . LEU   A 1 180 ? -25.69178 -25.85235 15.98295  1.000 31.22559  ? 185  LEU   A N    1 
ATOM   1189 C  CA   . LEU   A 1 180 ? -25.75568 -25.24626 14.66199  1.000 34.87258  ? 185  LEU   A CA   1 
ATOM   1190 C  C    . LEU   A 1 180 ? -24.52268 -25.61833 13.84401  1.000 35.87157  ? 185  LEU   A C    1 
ATOM   1191 O  O    . LEU   A 1 180 ? -23.42272 -25.80547 14.38804  1.000 31.78288  ? 185  LEU   A O    1 
ATOM   1192 C  CB   . LEU   A 1 180 ? -25.85953 -23.72226 14.76108  1.000 33.29737  ? 185  LEU   A CB   1 
ATOM   1193 C  CG   . LEU   A 1 180 ? -27.10851 -23.22119 15.49306  1.000 32.56678  ? 185  LEU   A CG   1 
ATOM   1194 C  CD1  . LEU   A 1 180 ? -27.12537 -21.70019 15.61616  1.000 25.76149  ? 185  LEU   A CD1  1 
ATOM   1195 C  CD2  . LEU   A 1 180 ? -28.35753 -23.72302 14.78698  1.000 31.15237  ? 185  LEU   A CD2  1 
ATOM   1196 N  N    . ILE   A 1 181 ? -24.72964 -25.74123 12.53299  1.000 31.26005  ? 186  ILE   A N    1 
ATOM   1197 C  CA   . ILE   A 1 181 ? -23.66361 -25.78527 11.53503  1.000 31.64237  ? 186  ILE   A CA   1 
ATOM   1198 C  C    . ILE   A 1 181 ? -23.86746 -24.60619 10.59010  1.000 32.12048  ? 186  ILE   A C    1 
ATOM   1199 O  O    . ILE   A 1 181 ? -25.00042 -24.32506 10.18207  1.000 34.95421  ? 186  ILE   A O    1 
ATOM   1200 C  CB   . ILE   A 1 181 ? -23.67771 -27.11222 10.74595  1.000 29.67923  ? 186  ILE   A CB   1 
ATOM   1201 C  CG1  . ILE   A 1 181 ? -23.31686 -28.29431 11.64989  1.000 26.79676  ? 186  ILE   A CG1  1 
ATOM   1202 C  CG2  . ILE   A 1 181 ? -22.74765 -27.02923 9.50199   1.000 27.00194  ? 186  ILE   A CG2  1 
ATOM   1203 C  CD1  . ILE   A 1 181 ? -23.85597 -29.60923 11.13578  1.000 28.14055  ? 186  ILE   A CD1  1 
ATOM   1204 N  N    . VAL   A 1 182 ? -22.78338 -23.90828 10.25018  1.000 30.59350  ? 187  VAL   A N    1 
ATOM   1205 C  CA   . VAL   A 1 182 ? -22.81524 -22.92221 9.17224   1.000 29.76787  ? 187  VAL   A CA   1 
ATOM   1206 C  C    . VAL   A 1 182 ? -22.00925 -23.48121 8.00824   1.000 31.42404  ? 187  VAL   A C    1 
ATOM   1207 O  O    . VAL   A 1 182 ? -20.97932 -24.13332 8.21724   1.000 29.58442  ? 187  VAL   A O    1 
ATOM   1208 C  CB   . VAL   A 1 182 ? -22.27012 -21.55029 9.60135   1.000 29.53587  ? 187  VAL   A CB   1 
ATOM   1209 C  CG1  . VAL   A 1 182 ? -20.79215 -21.64245 9.95340   1.000 29.79249  ? 187  VAL   A CG1  1 
ATOM   1210 C  CG2  . VAL   A 1 182 ? -22.52098 -20.51919 8.49541   1.000 26.77124  ? 187  VAL   A CG2  1 
ATOM   1211 N  N    . SER   A 1 183 ? -22.48618 -23.23209 6.78624   1.000 29.55838  ? 188  SER   A N    1 
ATOM   1212 C  CA   . SER   A 1 183 ? -21.80017 -23.62908 5.55524   1.000 23.97087  ? 188  SER   A CA   1 
ATOM   1213 C  C    . SER   A 1 183 ? -21.77602 -22.45402 4.58131   1.000 26.94762  ? 188  SER   A C    1 
ATOM   1214 O  O    . SER   A 1 183 ? -22.64594 -21.57794 4.61633   1.000 28.94665  ? 188  SER   A O    1 
ATOM   1215 C  CB   . SER   A 1 183 ? -22.48726 -24.83197 4.89914   1.000 24.30947  ? 188  SER   A CB   1 
ATOM   1216 O  OG   . SER   A 1 183 ? -23.78821 -24.45981 4.45411   1.000 25.48966  ? 188  SER   A OG   1 
ATOM   1217 N  N    . SER   A 1 184 ? -20.76199 -22.42506 3.71635   1.000 24.89531  ? 189  SER   A N    1 
ATOM   1218 C  CA   . SER   A 1 184 ? -20.63685 -21.38001 2.70442   1.000 25.03447  ? 189  SER   A CA   1 
ATOM   1219 C  C    . SER   A 1 184 ? -20.40586 -22.04195 1.35739   1.000 22.56529  ? 189  SER   A C    1 
ATOM   1220 O  O    . SER   A 1 184 ? -19.85996 -23.14800 1.28134   1.000 25.37093  ? 189  SER   A O    1 
ATOM   1221 C  CB   . SER   A 1 184 ? -19.48676 -20.40014 3.01653   1.000 21.73823  ? 189  SER   A CB   1 
ATOM   1222 O  OG   . SER   A 1 184 ? -18.25484 -21.11427 3.11453   1.000 20.58127  ? 189  SER   A OG   1 
ATOM   1223 N  N    . SER   A 1 185 ? -20.82675 -21.36984 0.29142   1.000 22.95675  ? 190  SER   A N    1 
ATOM   1224 C  CA   . SER   A 1 185 ? -20.78076 -21.99776 -1.02062  1.000 24.55460  ? 190  SER   A CA   1 
ATOM   1225 C  C    . SER   A 1 185 ? -20.49662 -20.97472 -2.10855  1.000 23.44700  ? 190  SER   A C    1 
ATOM   1226 O  O    . SER   A 1 185 ? -20.80451 -19.78970 -1.97148  1.000 22.36725  ? 190  SER   A O    1 
ATOM   1227 C  CB   . SER   A 1 185 ? -22.09982 -22.72261 -1.33072  1.000 24.63872  ? 190  SER   A CB   1 
ATOM   1228 O  OG   . SER   A 1 185 ? -22.12382 -23.17453 -2.67775  1.000 26.19086  ? 190  SER   A OG   1 
ATOM   1229 N  N    . TYR   A 1 186 ? -19.94063 -21.47371 -3.22056  1.000 22.02490  ? 191  TYR   A N    1 
ATOM   1230 C  CA   . TYR   A 1 186 ? -19.86251 -20.70364 -4.45251  1.000 22.50399  ? 191  TYR   A CA   1 
ATOM   1231 C  C    . TYR   A 1 186 ? -21.22445 -20.25047 -4.95353  1.000 25.77820  ? 191  TYR   A C    1 
ATOM   1232 O  O    . TYR   A 1 186 ? -21.28732 -19.33141 -5.78347  1.000 24.61668  ? 191  TYR   A O    1 
ATOM   1233 C  CB   . TYR   A 1 186 ? -19.15655 -21.53664 -5.53453  1.000 24.61681  ? 191  TYR   A CB   1 
ATOM   1234 C  CG   . TYR   A 1 186 ? -17.65254 -21.37879 -5.47046  1.000 24.36300  ? 191  TYR   A CG   1 
ATOM   1235 C  CD1  . TYR   A 1 186 ? -16.92563 -21.91192 -4.40547  1.000 24.37935  ? 191  TYR   A CD1  1 
ATOM   1236 C  CD2  . TYR   A 1 186 ? -16.96243 -20.65279 -6.44239  1.000 25.66864  ? 191  TYR   A CD2  1 
ATOM   1237 C  CE1  . TYR   A 1 186 ? -15.53262 -21.75806 -4.33241  1.000 25.25538  ? 191  TYR   A CE1  1 
ATOM   1238 C  CE2  . TYR   A 1 186 ? -15.58241 -20.49093 -6.37533  1.000 25.32667  ? 191  TYR   A CE2  1 
ATOM   1239 C  CZ   . TYR   A 1 186 ? -14.87851 -21.05106 -5.32834  1.000 23.83377  ? 191  TYR   A CZ   1 
ATOM   1240 O  OH   . TYR   A 1 186 ? -13.51449 -20.87420 -5.24727  1.000 29.43083  ? 191  TYR   A OH   1 
ATOM   1241 N  N    . ASP   A 1 187 ? -22.31952 -20.85740 -4.46961  1.000 22.13171  ? 192  ASP   A N    1 
ATOM   1242 C  CA   . ASP   A 1 187 ? -23.64146 -20.35524 -4.85763  1.000 27.17293  ? 192  ASP   A CA   1 
ATOM   1243 C  C    . ASP   A 1 187 ? -23.95735 -18.99425 -4.24755  1.000 28.71311  ? 192  ASP   A C    1 
ATOM   1244 O  O    . ASP   A 1 187 ? -25.04529 -18.46613 -4.47756  1.000 28.13305  ? 192  ASP   A O    1 
ATOM   1245 C  CB   . ASP   A 1 187 ? -24.74757 -21.38116 -4.51173  1.000 24.75702  ? 192  ASP   A CB   1 
ATOM   1246 C  CG   . ASP   A 1 187 ? -25.00265 -21.55123 -2.99575  1.000 26.56041  ? 192  ASP   A CG   1 
ATOM   1247 O  OD1  . ASP   A 1 187 ? -24.49760 -20.76633 -2.15169  1.000 27.31473  ? 192  ASP   A OD1  1 
ATOM   1248 O  OD2  . ASP   A 1 187 ? -25.75275 -22.51118 -2.65884  1.000 27.94839  ? 192  ASP   A OD2  1 
ATOM   1249 N  N    . GLY   A 1 188 ? -23.02732 -18.39939 -3.50748  1.000 26.57973  ? 193  GLY   A N    1 
ATOM   1250 C  CA   . GLY   A 1 188 ? -23.22321 -17.08040 -2.95841  1.000 24.34416  ? 193  GLY   A CA   1 
ATOM   1251 C  C    . GLY   A 1 188 ? -23.94426 -17.04142 -1.62443  1.000 26.19273  ? 193  GLY   A C    1 
ATOM   1252 O  O    . GLY   A 1 188 ? -24.16117 -15.95143 -1.10037  1.000 24.70845  ? 193  GLY   A O    1 
ATOM   1253 N  N    . LEU   A 1 189 ? -24.31039 -18.18442 -1.06152  1.000 25.07498  ? 194  LEU   A N    1 
ATOM   1254 C  CA   . LEU   A 1 189 ? -25.08544 -18.24042 0.16645   1.000 25.95602  ? 194  LEU   A CA   1 
ATOM   1255 C  C    . LEU   A 1 189 ? -24.24954 -18.73157 1.33245   1.000 27.19589  ? 194  LEU   A C    1 
ATOM   1256 O  O    . LEU   A 1 189 ? -23.32961 -19.53565 1.16144   1.000 25.63621  ? 194  LEU   A O    1 
ATOM   1257 C  CB   . LEU   A 1 189 ? -26.27453 -19.19629 0.03835   1.000 27.72124  ? 194  LEU   A CB   1 
ATOM   1258 C  CG   . LEU   A 1 189 ? -27.16047 -19.02313 -1.18168  1.000 24.88568  ? 194  LEU   A CG   1 
ATOM   1259 C  CD1  . LEU   A 1 189 ? -28.24258 -20.11203 -1.16779  1.000 29.44847  ? 194  LEU   A CD1  1 
ATOM   1260 C  CD2  . LEU   A 1 189 ? -27.75433 -17.62308 -1.15961  1.000 25.32696  ? 194  LEU   A CD2  1 
ATOM   1261 N  N    . CYS   A 1 190 ? -24.54853 -18.20162 2.51147   1.000 26.71072  ? 195  CYS   A N    1 
ATOM   1262 C  CA   . CYS   A 1 190 ? -24.26464 -18.88272 3.76544   1.000 28.06949  ? 195  CYS   A CA   1 
ATOM   1263 C  C    . CYS   A 1 190 ? -25.55972 -19.49263 4.27835   1.000 29.90823  ? 195  CYS   A C    1 
ATOM   1264 O  O    . CYS   A 1 190 ? -26.63166 -18.88052 4.17835   1.000 29.94361  ? 195  CYS   A O    1 
ATOM   1265 C  CB   . CYS   A 1 190 ? -23.69859 -17.92885 4.81652   1.000 32.53345  ? 195  CYS   A CB   1 
ATOM   1266 S  SG   . CYS   A 1 190 ? -22.06651 -17.28698 4.44163   1.000 34.62853  ? 195  CYS   A SG   1 
ATOM   1267 N  N    . ARG   A 1 191 ? -25.46286 -20.70867 4.80428   1.000 25.10097  ? 196  ARG   A N    1 
ATOM   1268 C  CA   . ARG   A 1 191 ? -26.63295 -21.37859 5.34120   1.000 30.68856  ? 196  ARG   A CA   1 
ATOM   1269 C  C    . ARG   A 1 191 ? -26.33605 -21.92271 6.73217   1.000 31.81925  ? 196  ARG   A C    1 
ATOM   1270 O  O    . ARG   A 1 191 ? -25.22011 -22.37083 7.00419   1.000 29.50165  ? 196  ARG   A O    1 
ATOM   1271 C  CB   . ARG   A 1 191 ? -27.11402 -22.48849 4.38211   1.000 29.24320  ? 196  ARG   A CB   1 
ATOM   1272 C  CG   . ARG   A 1 191 ? -28.00592 -21.89433 3.26511   1.000 30.58294  ? 196  ARG   A CG   1 
ATOM   1273 C  CD   . ARG   A 1 191 ? -28.51998 -22.89622 2.24703   1.000 26.66028  ? 196  ARG   A CD   1 
ATOM   1274 N  NE   . ARG   A 1 191 ? -29.51688 -22.22707 1.42003   1.000 28.37120  ? 196  ARG   A NE   1 
ATOM   1275 C  CZ   . ARG   A 1 191 ? -29.92688 -22.64795 0.23099   1.000 27.74141  ? 196  ARG   A CZ   1 
ATOM   1276 N  NH1  . ARG   A 1 191 ? -29.43396 -23.73896 -0.32706  1.000 24.12364  ? 196  ARG   A NH1  1 
ATOM   1277 N  NH2  . ARG   A 1 191 ? -30.85678 -21.95182 -0.41100  1.000 24.35450  ? 196  ARG   A NH2  1 
ATOM   1278 N  N    . ILE   A 1 192 ? -27.32908 -21.84167 7.62314   1.000 29.21543  ? 197  ILE   A N    1 
ATOM   1279 C  CA   . ILE   A 1 192 ? -27.23118 -22.38576 8.97911   1.000 30.40588  ? 197  ILE   A CA   1 
ATOM   1280 C  C    . ILE   A 1 192 ? -28.11230 -23.62068 9.05600   1.000 31.47762  ? 197  ILE   A C    1 
ATOM   1281 O  O    . ILE   A 1 192 ? -29.25629 -23.61554 8.57795   1.000 38.18357  ? 197  ILE   A O    1 
ATOM   1282 C  CB   . ILE   A 1 192 ? -27.66012 -21.36679 10.05916  1.000 29.86280  ? 197  ILE   A CB   1 
ATOM   1283 C  CG1  . ILE   A 1 192 ? -26.88899 -20.04986 9.95327   1.000 31.42155  ? 197  ILE   A CG1  1 
ATOM   1284 C  CG2  . ILE   A 1 192 ? -27.49924 -21.96989 11.44313  1.000 29.88482  ? 197  ILE   A CG2  1 
ATOM   1285 C  CD1  . ILE   A 1 192 ? -25.47402 -20.15102 10.33332  1.000 37.47984  ? 197  ILE   A CD1  1 
ATOM   1286 N  N    . TRP   A 1 193 ? -27.59143 -24.67277 9.67495   1.000 31.85267  ? 198  TRP   A N    1 
ATOM   1287 C  CA   . TRP   A 1 193 ? -28.28056 -25.94471 9.77585   1.000 33.32583  ? 198  TRP   A CA   1 
ATOM   1288 C  C    . TRP   A 1 193 ? -28.45665 -26.34379 11.23581  1.000 37.46183  ? 198  TRP   A C    1 
ATOM   1289 O  O    . TRP   A 1 193 ? -27.55067 -26.15693 12.05986  1.000 31.99171  ? 198  TRP   A O    1 
ATOM   1290 C  CB   . TRP   A 1 193 ? -27.51064 -27.02774 9.03081   1.000 34.09470  ? 198  TRP   A CB   1 
ATOM   1291 C  CG   . TRP   A 1 193 ? -27.19454 -26.58668 7.63585   1.000 35.26428  ? 198  TRP   A CG   1 
ATOM   1292 C  CD1  . TRP   A 1 193 ? -26.11545 -25.84376 7.22993   1.000 30.82105  ? 198  TRP   A CD1  1 
ATOM   1293 C  CD2  . TRP   A 1 193 ? -27.97952 -26.83753 6.45880   1.000 35.76433  ? 198  TRP   A CD2  1 
ATOM   1294 N  NE1  . TRP   A 1 193 ? -26.18138 -25.61767 5.86995   1.000 33.95445  ? 198  TRP   A NE1  1 
ATOM   1295 C  CE2  . TRP   A 1 193 ? -27.30542 -26.22153 5.36887   1.000 31.85080  ? 198  TRP   A CE2  1 
ATOM   1296 C  CE3  . TRP   A 1 193 ? -29.18158 -27.52440 6.21571   1.000 32.05581  ? 198  TRP   A CE3  1 
ATOM   1297 C  CZ2  . TRP   A 1 193 ? -27.79437 -26.26940 4.05784   1.000 32.74090  ? 198  TRP   A CZ2  1 
ATOM   1298 C  CZ3  . TRP   A 1 193 ? -29.66353 -27.57927 4.90969   1.000 34.53582  ? 198  TRP   A CZ3  1 
ATOM   1299 C  CH2  . TRP   A 1 193 ? -28.96943 -26.94927 3.84576   1.000 34.80916  ? 198  TRP   A CH2  1 
ATOM   1300 N  N    . ASP   A 1 194 ? -29.63672 -26.88469 11.54673  1.000 38.63046  ? 199  ASP   A N    1 
ATOM   1301 C  CA   . ASP   A 1 194 ? -29.86983 -27.51475 12.84169  1.000 35.57143  ? 199  ASP   A CA   1 
ATOM   1302 C  C    . ASP   A 1 194 ? -29.17696 -28.87182 12.84763  1.000 35.87605  ? 199  ASP   A C    1 
ATOM   1303 O  O    . ASP   A 1 194 ? -29.54802 -29.75873 12.07056  1.000 32.77098  ? 199  ASP   A O    1 
ATOM   1304 C  CB   . ASP   A 1 194 ? -31.37085 -27.67062 13.10262  1.000 41.88467  ? 199  ASP   A CB   1 
ATOM   1305 C  CG   . ASP   A 1 194 ? -31.65797 -28.37568 14.42256  1.000 35.88845  ? 199  ASP   A CG   1 
ATOM   1306 O  OD1  . ASP   A 1 194 ? -31.65809 -29.62868 14.45849  1.000 38.99999  ? 199  ASP   A OD1  1 
ATOM   1307 O  OD2  . ASP   A 1 194 ? -31.82794 -27.66672 15.42460  1.000 43.38431  ? 199  ASP   A OD2  1 
ATOM   1308 N  N    . THR   A 1 195 ? -28.17201 -29.03097 13.71666  1.000 34.02169  ? 200  THR   A N    1 
ATOM   1309 C  CA   . THR   A 1 195 ? -27.38313 -30.26205 13.70961  1.000 32.40417  ? 200  THR   A CA   1 
ATOM   1310 C  C    . THR   A 1 195 ? -28.26925 -31.48497 13.87750  1.000 38.58538  ? 200  THR   A C    1 
ATOM   1311 O  O    . THR   A 1 195 ? -28.12032 -32.48294 13.15844  1.000 41.29390  ? 200  THR   A O    1 
ATOM   1312 C  CB   . THR   A 1 195 ? -26.34517 -30.24522 14.82565  1.000 33.23340  ? 200  THR   A CB   1 
ATOM   1313 O  OG1  . THR   A 1 195 ? -25.54405 -29.06129 14.72175  1.000 30.66775  ? 200  THR   A OG1  1 
ATOM   1314 C  CG2  . THR   A 1 195 ? -25.46429 -31.51230 14.73160  1.000 31.92295  ? 200  THR   A CG2  1 
ATOM   1315 N  N    . ALA   A 1 196 ? -29.17229 -31.43894 14.85747  1.000 38.23205  ? 201  ALA   A N    1 
ATOM   1316 C  CA   . ALA   A 1 196 ? -29.96841 -32.61689 15.17836  1.000 41.70395  ? 201  ALA   A CA   1 
ATOM   1317 C  C    . ALA   A 1 196 ? -30.88640 -32.99173 14.02130  1.000 38.74670  ? 201  ALA   A C    1 
ATOM   1318 O  O    . ALA   A 1 196 ? -30.90250 -34.14570 13.56923  1.000 42.75470  ? 201  ALA   A O    1 
ATOM   1319 C  CB   . ALA   A 1 196 ? -30.76844 -32.36689 16.46135  1.000 37.23570  ? 201  ALA   A CB   1 
ATOM   1320 N  N    . SER   A 1 197 ? -31.64829 -32.02162 13.51234  1.000 39.14604  ? 202  SER   A N    1 
ATOM   1321 C  CA   . SER   A 1 197 ? -32.66128 -32.31046 12.51028  1.000 37.40953  ? 202  SER   A CA   1 
ATOM   1322 C  C    . SER   A 1 197 ? -32.13822 -32.25442 11.08330  1.000 39.21058  ? 202  SER   A C    1 
ATOM   1323 O  O    . SER   A 1 197 ? -32.73025 -32.89131 10.20124  1.000 41.41720  ? 202  SER   A O    1 
ATOM   1324 C  CB   . SER   A 1 197 ? -33.83419 -31.33335 12.65130  1.000 41.62801  ? 202  SER   A CB   1 
ATOM   1325 O  OG   . SER   A 1 197 ? -33.50505 -30.05835 12.12439  1.000 38.48085  ? 202  SER   A OG   1 
ATOM   1326 N  N    . GLY   A 1 198 ? -31.06314 -31.50951 10.82539  1.000 38.02123  ? 203  GLY   A N    1 
ATOM   1327 C  CA   . GLY   A 1 198 ? -30.61507 -31.30446 9.45942   1.000 38.04632  ? 203  GLY   A CA   1 
ATOM   1328 C  C    . GLY   A 1 198 ? -31.36893 -30.23634 8.70846   1.000 40.74342  ? 203  GLY   A C    1 
ATOM   1329 O  O    . GLY   A 1 198 ? -31.06287 -29.99030 7.52949   1.000 40.03402  ? 203  GLY   A O    1 
ATOM   1330 N  N    . GLN   A 1 199 ? -32.33690 -29.58629 9.34546   1.000 41.39070  ? 204  GLN   A N    1 
ATOM   1331 C  CA   . GLN   A 1 199 ? -33.12677 -28.55617 8.68250   1.000 41.29435  ? 204  GLN   A CA   1 
ATOM   1332 C  C    . GLN   A 1 199 ? -32.30264 -27.28124 8.54161   1.000 38.30066  ? 204  GLN   A C    1 
ATOM   1333 O  O    . GLN   A 1 199 ? -31.63663 -26.84337 9.48766   1.000 36.85244  ? 204  GLN   A O    1 
ATOM   1334 C  CB   . GLN   A 1 199 ? -34.42377 -28.26409 9.45147   1.000 37.64232  ? 204  GLN   A CB   1 
ATOM   1335 C  CG   . GLN   A 1 199 ? -35.60485 -29.23196 9.13736   1.000 50.59813  ? 204  GLN   A CG   1 
ATOM   1336 C  CD   . GLN   A 1 199 ? -35.69084 -29.68486 7.65733   1.000 62.38479  ? 204  GLN   A CD   1 
ATOM   1337 O  OE1  . GLN   A 1 199 ? -35.95373 -28.87977 6.73637   1.000 54.69464  ? 204  GLN   A OE1  1 
ATOM   1338 N  NE2  . GLN   A 1 199 ? -35.47896 -30.98786 7.43425   1.000 62.65302  ? 204  GLN   A NE2  1 
ATOM   1339 N  N    . CYS   A 1 200 ? -32.35154 -26.68716 7.35564   1.000 34.85713  ? 205  CYS   A N    1 
ATOM   1340 C  CA   . CYS   A 1 200 ? -31.79840 -25.35621 7.18875   1.000 34.51431  ? 205  CYS   A CA   1 
ATOM   1341 C  C    . CYS   A 1 200 ? -32.60334 -24.34718 8.00878   1.000 32.27827  ? 205  CYS   A C    1 
ATOM   1342 O  O    . CYS   A 1 200 ? -33.83132 -24.25205 7.87874   1.000 35.39141  ? 205  CYS   A O    1 
ATOM   1343 C  CB   . CYS   A 1 200 ? -31.78031 -24.97212 5.71077   1.000 29.95081  ? 205  CYS   A CB   1 
ATOM   1344 S  SG   . CYS   A 1 200 ? -31.04414 -23.36417 5.45990   1.000 30.84358  ? 205  CYS   A SG   1 
ATOM   1345 N  N    . LEU   A 1 201 ? -31.90629 -23.58730 8.85486   1.000 33.79038  ? 206  LEU   A N    1 
ATOM   1346 C  CA   . LEU   A 1 201 ? -32.53723 -22.61529 9.72689   1.000 30.27944  ? 206  LEU   A CA   1 
ATOM   1347 C  C    . LEU   A 1 201 ? -32.29008 -21.17529 9.30899   1.000 34.40008  ? 206  LEU   A C    1 
ATOM   1348 O  O    . LEU   A 1 201 ? -32.91201 -20.26727 9.86903   1.000 33.95776  ? 206  LEU   A O    1 
ATOM   1349 C  CB   . LEU   A 1 201 ? -32.03931 -22.80343 11.16290  1.000 35.22865  ? 206  LEU   A CB   1 
ATOM   1350 C  CG   . LEU   A 1 201 ? -32.34046 -24.19744 11.71280  1.000 42.24909  ? 206  LEU   A CG   1 
ATOM   1351 C  CD1  . LEU   A 1 201 ? -31.83853 -24.33858 13.15381  1.000 42.69988  ? 206  LEU   A CD1  1 
ATOM   1352 C  CD2  . LEU   A 1 201 ? -33.84348 -24.44229 11.63273  1.000 42.33369  ? 206  LEU   A CD2  1 
ATOM   1353 N  N    . LYS   A 1 202 ? -31.38902 -20.93132 8.36804   1.000 32.81237  ? 207  LYS   A N    1 
ATOM   1354 C  CA   . LYS   A 1 202 ? -31.14487 -19.56932 7.92414   1.000 29.80102  ? 207  LYS   A CA   1 
ATOM   1355 C  C    . LYS   A 1 202 ? -30.43782 -19.62030 6.57616   1.000 32.15570  ? 207  LYS   A C    1 
ATOM   1356 O  O    . LYS   A 1 202 ? -29.62090 -20.51037 6.33714   1.000 27.79961  ? 207  LYS   A O    1 
ATOM   1357 C  CB   . LYS   A 1 202 ? -30.30583 -18.79646 8.95322   1.000 31.61410  ? 207  LYS   A CB   1 
ATOM   1358 C  CG   . LYS   A 1 202 ? -30.21968 -17.29646 8.69632   1.000 31.19462  ? 207  LYS   A CG   1 
ATOM   1359 C  CD   . LYS   A 1 202 ? -31.46963 -16.58137 9.19431   1.000 38.91371  ? 207  LYS   A CD   1 
ATOM   1360 C  CE   . LYS   A 1 202 ? -31.43147 -15.09435 8.81541   1.000 49.80544  ? 207  LYS   A CE   1 
ATOM   1361 N  NZ   . LYS   A 1 202 ? -32.62941 -14.29826 9.27941   1.000 47.87694  ? 207  LYS   A NZ   1 
ATOM   1362 N  N    . THR   A 1 203 ? -30.78470 -18.68421 5.69121   1.000 30.18897  ? 208  THR   A N    1 
ATOM   1363 C  CA   . THR   A 1 203 ? -30.03063 -18.45121 4.47025   1.000 31.19842  ? 208  THR   A CA   1 
ATOM   1364 C  C    . THR   A 1 203 ? -29.62049 -16.98625 4.48936   1.000 31.11335  ? 208  THR   A C    1 
ATOM   1365 O  O    . THR   A 1 203 ? -30.48240 -16.09717 4.53638   1.000 31.12060  ? 208  THR   A O    1 
ATOM   1366 C  CB   . THR   A 1 203 ? -30.83562 -18.81205 3.20720   1.000 27.49073  ? 208  THR   A CB   1 
ATOM   1367 O  OG1  . THR   A 1 203 ? -30.98975 -20.23403 3.11410   1.000 30.98613  ? 208  THR   A OG1  1 
ATOM   1368 C  CG2  . THR   A 1 203 ? -30.13552 -18.29804 1.92526   1.000 28.45947  ? 208  THR   A CG2  1 
ATOM   1369 N  N    . LEU   A 1 204 ? -28.31146 -16.73938 4.47942   1.000 30.91459  ? 209  LEU   A N    1 
ATOM   1370 C  CA   . LEU   A 1 204 ? -27.76933 -15.38743 4.52853   1.000 30.88517  ? 209  LEU   A CA   1 
ATOM   1371 C  C    . LEU   A 1 204 ? -27.33924 -14.99439 3.12957   1.000 32.96712  ? 209  LEU   A C    1 
ATOM   1372 O  O    . LEU   A 1 204 ? -26.53729 -15.69242 2.50356   1.000 28.79581  ? 209  LEU   A O    1 
ATOM   1373 C  CB   . LEU   A 1 204 ? -26.57936 -15.29361 5.48358   1.000 35.03518  ? 209  LEU   A CB   1 
ATOM   1374 C  CG   . LEU   A 1 204 ? -26.85146 -15.74267 6.91754   1.000 41.86695  ? 209  LEU   A CG   1 
ATOM   1375 C  CD1  . LEU   A 1 204 ? -25.55449 -15.78885 7.74059   1.000 50.46513  ? 209  LEU   A CD1  1 
ATOM   1376 C  CD2  . LEU   A 1 204 ? -27.90040 -14.84161 7.58156   1.000 43.88372  ? 209  LEU   A CD2  1 
ATOM   1377 N  N    . ILE   A 1 205 ? -27.86912 -13.88430 2.64562   1.000 32.65888  ? 210  ILE   A N    1 
ATOM   1378 C  CA   . ILE   A 1 205 ? -27.42901 -13.28627 1.38967   1.000 37.39327  ? 210  ILE   A CA   1 
ATOM   1379 C  C    . ILE   A 1 205 ? -27.56487 -11.78326 1.56576   1.000 43.26254  ? 210  ILE   A C    1 
ATOM   1380 O  O    . ILE   A 1 205 ? -28.47085 -11.32022 2.26176   1.000 50.63750  ? 210  ILE   A O    1 
ATOM   1381 C  CB   . ILE   A 1 205 ? -28.25402 -13.83011 0.18961   1.000 42.67419  ? 210  ILE   A CB   1 
ATOM   1382 C  CG1  . ILE   A 1 205 ? -27.71792 -13.33208 -1.15134  1.000 45.56968  ? 210  ILE   A CG1  1 
ATOM   1383 C  CG2  . ILE   A 1 205 ? -29.73299 -13.46797 0.29757   1.000 39.53759  ? 210  ILE   A CG2  1 
ATOM   1384 C  CD1  . ILE   A 1 205 ? -28.28794 -14.07495 -2.33141  1.000 48.44494  ? 210  ILE   A CD1  1 
ATOM   1385 N  N    . ASP   A 1 206 ? -26.64377 -11.01632 0.98685   1.000 42.50026  ? 211  ASP   A N    1 
ATOM   1386 C  CA   . ASP   A 1 206 ? -26.74964 -9.56432  1.10893   1.000 52.70956  ? 211  ASP   A CA   1 
ATOM   1387 C  C    . ASP   A 1 206 ? -27.13952 -8.92619  -0.22404  1.000 56.99830  ? 211  ASP   A C    1 
ATOM   1388 O  O    . ASP   A 1 206 ? -28.04555 -9.41806  -0.90511  1.000 54.96845  ? 211  ASP   A O    1 
ATOM   1389 C  CB   . ASP   A 1 206 ? -25.44460 -8.97048  1.64902   1.000 49.76316  ? 211  ASP   A CB   1 
ATOM   1390 C  CG   . ASP   A 1 206 ? -24.24660 -9.30454  0.78605   1.000 61.04060  ? 211  ASP   A CG   1 
ATOM   1391 O  OD1  . ASP   A 1 206 ? -24.45059 -9.71445  -0.38399  1.000 62.56511  ? 211  ASP   A OD1  1 
ATOM   1392 O  OD2  . ASP   A 1 206 ? -23.09360 -9.16468  1.27710   1.000 59.79960  ? 211  ASP   A OD2  1 
ATOM   1393 N  N    . ASP   A 1 207 ? -26.47540 -7.82823  -0.60095  1.000 55.64707  ? 212  ASP   A N    1 
ATOM   1394 C  CA   . ASP   A 1 207 ? -26.86028 -7.05412  -1.77891  1.000 59.55665  ? 212  ASP   A CA   1 
ATOM   1395 C  C    . ASP   A 1 207 ? -26.47930 -7.72508  -3.09094  1.000 59.31979  ? 212  ASP   A C    1 
ATOM   1396 O  O    . ASP   A 1 207 ? -27.07523 -7.41195  -4.13094  1.000 63.50039  ? 212  ASP   A O    1 
ATOM   1397 C  CB   . ASP   A 1 207 ? -26.22315 -5.66819  -1.71380  1.000 60.59782  ? 212  ASP   A CB   1 
ATOM   1398 C  CG   . ASP   A 1 207 ? -24.81518 -5.71336  -1.14575  1.000 70.51262  ? 212  ASP   A CG   1 
ATOM   1399 O  OD1  . ASP   A 1 207 ? -23.99223 -6.50541  -1.66677  1.000 70.48626  ? 212  ASP   A OD1  1 
ATOM   1400 O  OD2  . ASP   A 1 207 ? -24.53314 -4.97445  -0.17069  1.000 77.14055  ? 212  ASP   A OD2  1 
ATOM   1401 N  N    . ASP   A 1 208 ? -25.50039 -8.62217  -3.06696  1.000 54.70428  ? 213  ASP   A N    1 
ATOM   1402 C  CA   . ASP   A 1 208 ? -25.09942 -9.37714  -4.23699  1.000 53.54357  ? 213  ASP   A CA   1 
ATOM   1403 C  C    . ASP   A 1 208 ? -24.78557 -10.79520 -3.77207  1.000 54.94505  ? 213  ASP   A C    1 
ATOM   1404 O  O    . ASP   A 1 208 ? -24.85165 -11.09927 -2.57109  1.000 47.38510  ? 213  ASP   A O    1 
ATOM   1405 C  CB   . ASP   A 1 208 ? -23.91132 -8.70421  -4.92790  1.000 55.71831  ? 213  ASP   A CB   1 
ATOM   1406 C  CG   . ASP   A 1 208 ? -24.29417 -7.41813  -5.61484  1.000 78.55965  ? 213  ASP   A CG   1 
ATOM   1407 O  OD1  . ASP   A 1 208 ? -25.51014 -7.17700  -5.81087  1.000 89.76783  ? 213  ASP   A OD1  1 
ATOM   1408 O  OD2  . ASP   A 1 208 ? -23.37808 -6.64720  -5.96775  1.000 76.58448  ? 213  ASP   A OD2  1 
ATOM   1409 N  N    . ASN   A 1 209 ? -24.45662 -11.68717 -4.71111  1.000 38.15621  ? 214  ASN   A N    1 
ATOM   1410 C  CA   . ASN   A 1 209 ? -24.09377 -13.06023 -4.34819  1.000 40.69615  ? 214  ASN   A CA   1 
ATOM   1411 C  C    . ASN   A 1 209 ? -22.81279 -13.52531 -5.05417  1.000 33.75345  ? 214  ASN   A C    1 
ATOM   1412 O  O    . ASN   A 1 209 ? -22.79686 -14.54527 -5.74823  1.000 34.90934  ? 214  ASN   A O    1 
ATOM   1413 C  CB   . ASN   A 1 209 ? -25.26885 -14.01510 -4.59629  1.000 41.36729  ? 214  ASN   A CB   1 
ATOM   1414 C  CG   . ASN   A 1 209 ? -25.46483 -14.34799 -6.04532  1.000 49.21659  ? 214  ASN   A CG   1 
ATOM   1415 O  OD1  . ASN   A 1 209 ? -25.59471 -13.46392 -6.88827  1.000 55.71343  ? 214  ASN   A OD1  1 
ATOM   1416 N  ND2  . ASN   A 1 209 ? -25.46194 -15.65297 -6.35840  1.000 53.97735  ? 214  ASN   A ND2  1 
ATOM   1417 N  N    . PRO   A 1 210 ? -21.70073 -12.81743 -4.84708  1.000 33.22668  ? 215  PRO   A N    1 
ATOM   1418 C  CA   . PRO   A 1 210 ? -20.40277 -13.40454 -5.17907  1.000 32.01032  ? 215  PRO   A CA   1 
ATOM   1419 C  C    . PRO   A 1 210 ? -20.19393 -14.69261 -4.40514  1.000 26.07904  ? 215  PRO   A C    1 
ATOM   1420 O  O    . PRO   A 1 210 ? -20.79599 -14.89861 -3.33718  1.000 25.08906  ? 215  PRO   A O    1 
ATOM   1421 C  CB   . PRO   A 1 210 ? -19.40968 -12.32566 -4.72796  1.000 32.63196  ? 215  PRO   A CB   1 
ATOM   1422 C  CG   . PRO   A 1 210 ? -20.10966 -11.66067 -3.57895  1.000 28.68770  ? 215  PRO   A CG   1 
ATOM   1423 C  CD   . PRO   A 1 210 ? -21.56164 -11.59950 -4.02800  1.000 30.69820  ? 215  PRO   A CD   1 
ATOM   1424 N  N    . PRO   A 1 211 ? -19.37999 -15.59865 -4.93217  1.000 25.89539  ? 216  PRO   A N    1 
ATOM   1425 C  CA   . PRO   A 1 211 ? -19.06214 -16.82573 -4.18923  1.000 26.51462  ? 216  PRO   A CA   1 
ATOM   1426 C  C    . PRO   A 1 211 ? -18.65017 -16.54086 -2.75220  1.000 23.42204  ? 216  PRO   A C    1 
ATOM   1427 O  O    . PRO   A 1 211 ? -17.86709 -15.62595 -2.48111  1.000 23.05368  ? 216  PRO   A O    1 
ATOM   1428 C  CB   . PRO   A 1 211 ? -17.90617 -17.42279 -4.99622  1.000 24.37584  ? 216  PRO   A CB   1 
ATOM   1429 C  CG   . PRO   A 1 211 ? -18.22007 -16.97467 -6.44321  1.000 25.02839  ? 216  PRO   A CG   1 
ATOM   1430 C  CD   . PRO   A 1 211 ? -18.81394 -15.59362 -6.29614  1.000 27.33076  ? 216  PRO   A CD   1 
ATOM   1431 N  N    . VAL   A 1 212 ? -19.20528 -17.31486 -1.82027  1.000 21.17926  ? 217  VAL   A N    1 
ATOM   1432 C  CA   . VAL   A 1 212 ? -18.80732 -17.23899 -0.41725  1.000 22.02141  ? 217  VAL   A CA   1 
ATOM   1433 C  C    . VAL   A 1 212 ? -17.69143 -18.27011 -0.24027  1.000 24.65705  ? 217  VAL   A C    1 
ATOM   1434 O  O    . VAL   A 1 212 ? -17.92755 -19.47908 -0.31235  1.000 25.03831  ? 217  VAL   A O    1 
ATOM   1435 C  CB   . VAL   A 1 212 ? -19.97739 -17.49294 0.53869   1.000 23.59328  ? 217  VAL   A CB   1 
ATOM   1436 C  CG1  . VAL   A 1 212 ? -19.53341 -17.23007 1.97773   1.000 18.85085  ? 217  VAL   A CG1  1 
ATOM   1437 C  CG2  . VAL   A 1 212 ? -21.16528 -16.57680 0.18470   1.000 26.33039  ? 217  VAL   A CG2  1 
ATOM   1438 N  N    . SER   A 1 213 ? -16.46339 -17.77924 -0.06619  1.000 24.04414  ? 218  SER   A N    1 
ATOM   1439 C  CA   . SER   A 1 213 ? -15.24747 -18.58536 -0.10120  1.000 21.42222  ? 218  SER   A CA   1 
ATOM   1440 C  C    . SER   A 1 213 ? -14.83057 -19.08248 1.27679   1.000 22.31052  ? 218  SER   A C    1 
ATOM   1441 O  O    . SER   A 1 213 ? -13.98766 -19.98157 1.37576   1.000 21.98227  ? 218  SER   A O    1 
ATOM   1442 C  CB   . SER   A 1 213 ? -14.12036 -17.75543 -0.72710  1.000 21.97554  ? 218  SER   A CB   1 
ATOM   1443 O  OG   . SER   A 1 213 ? -14.01027 -16.51648 -0.06202  1.000 21.48456  ? 218  SER   A OG   1 
ATOM   1444 N  N    . PHE   A 1 214 ? -15.43856 -18.55049 2.33480   1.000 21.06406  ? 219  PHE   A N    1 
ATOM   1445 C  CA   . PHE   A 1 214 ? -15.10865 -18.94961 3.69279   1.000 24.08439  ? 219  PHE   A CA   1 
ATOM   1446 C  C    . PHE   A 1 214 ? -16.20264 -18.48056 4.63577   1.000 25.01481  ? 219  PHE   A C    1 
ATOM   1447 O  O    . PHE   A 1 214 ? -16.81053 -17.42849 4.42182   1.000 23.47225  ? 219  PHE   A O    1 
ATOM   1448 C  CB   . PHE   A 1 214 ? -13.77361 -18.36477 4.14887   1.000 20.79738  ? 219  PHE   A CB   1 
ATOM   1449 C  CG   . PHE   A 1 214 ? -13.51968 -18.56988 5.58387   1.000 24.09741  ? 219  PHE   A CG   1 
ATOM   1450 C  CD1  . PHE   A 1 214 ? -13.13582 -19.82295 6.05081   1.000 27.08188  ? 219  PHE   A CD1  1 
ATOM   1451 C  CD2  . PHE   A 1 214 ? -13.70962 -17.54392 6.48093   1.000 29.01454  ? 219  PHE   A CD2  1 
ATOM   1452 C  CE1  . PHE   A 1 214 ? -12.92189 -20.04605 7.39480   1.000 27.71483  ? 219  PHE   A CE1  1 
ATOM   1453 C  CE2  . PHE   A 1 214 ? -13.49469 -17.74303 7.83092   1.000 28.52707  ? 219  PHE   A CE2  1 
ATOM   1454 C  CZ   . PHE   A 1 214 ? -13.10783 -19.00309 8.29186   1.000 30.39780  ? 219  PHE   A CZ   1 
ATOM   1455 N  N    . VAL   A 1 215 ? -16.41275 -19.24261 5.70972   1.000 21.20248  ? 220  VAL   A N    1 
ATOM   1456 C  CA   . VAL   A 1 215 ? -17.30075 -18.79459 6.78071   1.000 26.52274  ? 220  VAL   A CA   1 
ATOM   1457 C  C    . VAL   A 1 215 ? -16.94587 -19.54770 8.04568   1.000 25.91149  ? 220  VAL   A C    1 
ATOM   1458 O  O    . VAL   A 1 215 ? -16.42598 -20.66675 7.98863   1.000 27.20813  ? 220  VAL   A O    1 
ATOM   1459 C  CB   . VAL   A 1 215 ? -18.79276 -19.00042 6.40964   1.000 23.90038  ? 220  VAL   A CB   1 
ATOM   1460 C  CG1  . VAL   A 1 215 ? -19.15290 -20.46839 6.44354   1.000 23.58899  ? 220  VAL   A CG1  1 
ATOM   1461 C  CG2  . VAL   A 1 215 ? -19.68271 -18.20239 7.34966   1.000 30.45052  ? 220  VAL   A CG2  1 
ATOM   1462 N  N    . LYS   A 1 216 ? -17.22685 -18.92475 9.19871   1.000 29.31259  ? 221  LYS   A N    1 
ATOM   1463 C  CA   . LYS   A 1 216 ? -17.14497 -19.59384 10.49467  1.000 27.18056  ? 221  LYS   A CA   1 
ATOM   1464 C  C    . LYS   A 1 216 ? -17.88093 -18.75483 11.53769  1.000 30.30614  ? 221  LYS   A C    1 
ATOM   1465 O  O    . LYS   A 1 216 ? -18.04280 -17.53581 11.38576  1.000 33.44325  ? 221  LYS   A O    1 
ATOM   1466 C  CB   . LYS   A 1 216 ? -15.69001 -19.82001 10.93371  1.000 26.22434  ? 221  LYS   A CB   1 
ATOM   1467 C  CG   . LYS   A 1 216 ? -15.16292 -18.65911 11.73880  1.000 31.59654  ? 221  LYS   A CG   1 
ATOM   1468 C  CD   . LYS   A 1 216 ? -13.65794 -18.70527 11.92586  1.000 36.60236  ? 221  LYS   A CD   1 
ATOM   1469 C  CE   . LYS   A 1 216 ? -13.20609 -20.00435 12.55879  1.000 38.97660  ? 221  LYS   A CE   1 
ATOM   1470 N  NZ   . LYS   A 1 216 ? -11.74109 -19.91351 12.84185  1.000 46.19372  ? 221  LYS   A NZ   1 
ATOM   1471 N  N    . PHE   A 1 217 ? -18.31703 -19.43086 12.60463  1.000 26.64868  ? 222  PHE   A N    1 
ATOM   1472 C  CA   . PHE   A 1 217 ? -18.92501 -18.76887 13.75865  1.000 34.60551  ? 222  PHE   A CA   1 
ATOM   1473 C  C    . PHE   A 1 217 ? -17.88597 -17.99602 14.55974  1.000 35.97587  ? 222  PHE   A C    1 
ATOM   1474 O  O    . PHE   A 1 217 ? -16.74902 -18.44914 14.72875  1.000 33.77257  ? 222  PHE   A O    1 
ATOM   1475 C  CB   . PHE   A 1 217 ? -19.58215 -19.79787 14.68956  1.000 26.85238  ? 222  PHE   A CB   1 
ATOM   1476 C  CG   . PHE   A 1 217 ? -20.88618 -20.32971 14.18448  1.000 30.23853  ? 222  PHE   A CG   1 
ATOM   1477 C  CD1  . PHE   A 1 217 ? -22.01310 -19.51360 14.15849  1.000 30.41083  ? 222  PHE   A CD1  1 
ATOM   1478 C  CD2  . PHE   A 1 217 ? -20.99129 -21.65467 13.75739  1.000 29.96189  ? 222  PHE   A CD2  1 
ATOM   1479 C  CE1  . PHE   A 1 217 ? -23.23213 -19.99945 13.70841  1.000 30.77397  ? 222  PHE   A CE1  1 
ATOM   1480 C  CE2  . PHE   A 1 217 ? -22.20332 -22.16352 13.30331  1.000 28.60919  ? 222  PHE   A CE2  1 
ATOM   1481 C  CZ   . PHE   A 1 217 ? -23.33124 -21.33541 13.27632  1.000 34.22651  ? 222  PHE   A CZ   1 
ATOM   1482 N  N    . SER   A 1 218 ? -18.30188 -16.85102 15.10480  1.000 35.81645  ? 223  SER   A N    1 
ATOM   1483 C  CA   . SER   A 1 218 ? -17.47185 -16.14916 16.08087  1.000 44.47130  ? 223  SER   A CA   1 
ATOM   1484 C  C    . SER   A 1 218 ? -17.29797 -16.97926 17.36183  1.000 45.46854  ? 223  SER   A C    1 
ATOM   1485 O  O    . SER   A 1 218 ? -18.09307 -17.88320 17.65474  1.000 41.46765  ? 223  SER   A O    1 
ATOM   1486 C  CB   . SER   A 1 218 ? -18.06773 -14.78112 16.43094  1.000 42.77099  ? 223  SER   A CB   1 
ATOM   1487 O  OG   . SER   A 1 218 ? -19.28577 -14.92205 17.14088  1.000 41.35125  ? 223  SER   A OG   1 
ATOM   1488 N  N    . PRO   A 1 219 ? -16.24598 -16.69141 18.13788  1.000 47.26510  ? 224  PRO   A N    1 
ATOM   1489 C  CA   . PRO   A 1 219 ? -16.03010 -17.43951 19.38885  1.000 50.31346  ? 224  PRO   A CA   1 
ATOM   1490 C  C    . PRO   A 1 219 ? -17.22713 -17.46045 20.32780  1.000 48.92810  ? 224  PRO   A C    1 
ATOM   1491 O  O    . PRO   A 1 219 ? -17.47826 -18.49646 20.95072  1.000 50.86146  ? 224  PRO   A O    1 
ATOM   1492 C  CB   . PRO   A 1 219 ? -14.82905 -16.72066 20.00194  1.000 51.32762  ? 224  PRO   A CB   1 
ATOM   1493 C  CG   . PRO   A 1 219 ? -14.04396 -16.29166 18.78899  1.000 49.59685  ? 224  PRO   A CG   1 
ATOM   1494 C  CD   . PRO   A 1 219 ? -15.07588 -15.86850 17.77698  1.000 42.18094  ? 224  PRO   A CD   1 
ATOM   1495 N  N    . ASN   A 1 220 ? -17.97003 -16.36139 20.45184  1.000 51.82079  ? 225  ASN   A N    1 
ATOM   1496 C  CA   . ASN   A 1 220 ? -19.15206 -16.31932 21.30680  1.000 54.19470  ? 225  ASN   A CA   1 
ATOM   1497 C  C    . ASN   A 1 220 ? -20.40809 -16.88216 20.63471  1.000 54.77231  ? 225  ASN   A C    1 
ATOM   1498 O  O    . ASN   A 1 220 ? -21.48411 -16.84809 21.24368  1.000 54.24741  ? 225  ASN   A O    1 
ATOM   1499 C  CB   . ASN   A 1 220 ? -19.40694 -14.88033 21.76988  1.000 50.75019  ? 225  ASN   A CB   1 
ATOM   1500 C  CG   . ASN   A 1 220 ? -20.18182 -14.05819 20.74490  1.000 58.70272  ? 225  ASN   A CG   1 
ATOM   1501 O  OD1  . ASN   A 1 220 ? -20.13580 -14.32112 19.54289  1.000 57.11768  ? 225  ASN   A OD1  1 
ATOM   1502 N  ND2  . ASN   A 1 220 ? -20.90974 -13.05615 21.22494  1.000 64.32417  ? 225  ASN   A ND2  1 
ATOM   1503 N  N    . GLY   A 1 221 ? -20.30309 -17.39109 19.40269  1.000 51.73056  ? 226  GLY   A N    1 
ATOM   1504 C  CA   . GLY   A 1 221 ? -21.42513 -17.99894 18.71761  1.000 45.43228  ? 226  GLY   A CA   1 
ATOM   1505 C  C    . GLY   A 1 221 ? -22.45001 -17.04181 18.15663  1.000 47.68292  ? 226  GLY   A C    1 
ATOM   1506 O  O    . GLY   A 1 221 ? -23.33803 -17.48567 17.41457  1.000 49.90745  ? 226  GLY   A O    1 
ATOM   1507 N  N    . LYS   A 1 222 ? -22.35190 -15.74283 18.45871  1.000 48.13913  ? 227  LYS   A N    1 
ATOM   1508 C  CA   . LYS   A 1 222 ? -23.37879 -14.77471 18.08173  1.000 53.38063  ? 227  LYS   A CA   1 
ATOM   1509 C  C    . LYS   A 1 222 ? -23.27369 -14.31463 16.63477  1.000 54.33652  ? 227  LYS   A C    1 
ATOM   1510 O  O    . LYS   A 1 222 ? -24.28763 -13.89449 16.05275  1.000 52.70376  ? 227  LYS   A O    1 
ATOM   1511 C  CB   . LYS   A 1 222 ? -23.31370 -13.54777 19.00081  1.000 59.62741  ? 227  LYS   A CB   1 
ATOM   1512 C  CG   . LYS   A 1 222 ? -23.80578 -13.82482 20.43078  1.000 67.39416  ? 227  LYS   A CG   1 
ATOM   1513 C  CD   . LYS   A 1 222 ? -23.89569 -12.54786 21.26585  1.000 72.88064  ? 227  LYS   A CD   1 
ATOM   1514 C  CE   . LYS   A 1 222 ? -24.71976 -12.75986 22.53581  1.000 78.58613  ? 227  LYS   A CE   1 
ATOM   1515 N  NZ   . LYS   A 1 222 ? -24.26291 -13.93496 23.33875  1.000 79.07834  ? 227  LYS   A NZ   1 
ATOM   1516 N  N    . TYR   A 1 223 ? -22.08667 -14.38471 16.03981  1.000 48.50354  ? 228  TYR   A N    1 
ATOM   1517 C  CA   . TYR   A 1 223 ? -21.85757 -13.82765 14.71885  1.000 43.06221  ? 228  TYR   A CA   1 
ATOM   1518 C  C    . TYR   A 1 223 ? -21.28464 -14.88464 13.78681  1.000 39.78604  ? 228  TYR   A C    1 
ATOM   1519 O  O    . TYR   A 1 223 ? -20.89376 -15.98671 14.19175  1.000 37.12007  ? 228  TYR   A O    1 
ATOM   1520 C  CB   . TYR   A 1 223 ? -20.90645 -12.62874 14.77296  1.000 42.06484  ? 228  TYR   A CB   1 
ATOM   1521 C  CG   . TYR   A 1 223 ? -21.26040 -11.63578 15.84501  1.000 47.66679  ? 228  TYR   A CG   1 
ATOM   1522 C  CD1  . TYR   A 1 223 ? -22.42732 -10.88666 15.76801  1.000 49.75755  ? 228  TYR   A CD1  1 
ATOM   1523 C  CD2  . TYR   A 1 223 ? -20.43242 -11.45593 16.94405  1.000 54.68868  ? 228  TYR   A CD2  1 
ATOM   1524 C  CE1  . TYR   A 1 223 ? -22.75927 -9.97569  16.75506  1.000 55.80305  ? 228  TYR   A CE1  1 
ATOM   1525 C  CE2  . TYR   A 1 223 ? -20.75037 -10.54496 17.93810  1.000 60.90974  ? 228  TYR   A CE2  1 
ATOM   1526 C  CZ   . TYR   A 1 223 ? -21.91730 -9.80784  17.83910  1.000 57.82474  ? 228  TYR   A CZ   1 
ATOM   1527 O  OH   . TYR   A 1 223 ? -22.23825 -8.90187  18.82315  1.000 66.07963  ? 228  TYR   A OH   1 
ATOM   1528 N  N    . ILE   A 1 224 ? -21.27255 -14.55656 12.50183  1.000 40.41597  ? 229  ILE   A N    1 
ATOM   1529 C  CA   . ILE   A 1 224 ? -20.48459 -15.32258 11.55181  1.000 34.32027  ? 229  ILE   A CA   1 
ATOM   1530 C  C    . ILE   A 1 224 ? -19.58247 -14.34662 10.82391  1.000 31.27997  ? 229  ILE   A C    1 
ATOM   1531 O  O    . ILE   A 1 224 ? -19.90235 -13.16258 10.66697  1.000 32.48778  ? 229  ILE   A O    1 
ATOM   1532 C  CB   . ILE   A 1 224 ? -21.35064 -16.14444 10.56672  1.000 32.70352  ? 229  ILE   A CB   1 
ATOM   1533 C  CG1  . ILE   A 1 224 ? -22.34452 -15.23329 9.83874   1.000 38.86595  ? 229  ILE   A CG1  1 
ATOM   1534 C  CG2  . ILE   A 1 224 ? -22.04878 -17.29941 11.31263  1.000 33.50523  ? 229  ILE   A CG2  1 
ATOM   1535 C  CD1  . ILE   A 1 224 ? -22.34548 -15.41920 8.35173   1.000 42.27226  ? 229  ILE   A CD1  1 
ATOM   1536 N  N    . LEU   A 1 225 ? -18.43050 -14.85071 10.41092  1.000 29.97016  ? 230  LEU   A N    1 
ATOM   1537 C  CA   . LEU   A 1 225 ? -17.47340 -14.11775 9.59200   1.000 28.31668  ? 230  LEU   A CA   1 
ATOM   1538 C  C    . LEU   A 1 225 ? -17.41842 -14.80867 8.23496   1.000 30.24740  ? 230  LEU   A C    1 
ATOM   1539 O  O    . LEU   A 1 225 ? -17.13353 -16.01369 8.16989   1.000 28.59706  ? 230  LEU   A O    1 
ATOM   1540 C  CB   . LEU   A 1 225 ? -16.10843 -14.10193 10.27105  1.000 33.17209  ? 230  LEU   A CB   1 
ATOM   1541 C  CG   . LEU   A 1 225 ? -14.96533 -13.42499 9.52614   1.000 28.43030  ? 230  LEU   A CG   1 
ATOM   1542 C  CD1  . LEU   A 1 225 ? -15.20718 -11.93696 9.36022   1.000 28.38661  ? 230  LEU   A CD1  1 
ATOM   1543 C  CD2  . LEU   A 1 225 ? -13.67339 -13.71016 10.26317  1.000 28.58783  ? 230  LEU   A CD2  1 
ATOM   1544 N  N    . ALA   A 1 226 ? -17.73330 -14.07257 7.16199   1.000 27.78101  ? 231  ALA   A N    1 
ATOM   1545 C  CA   . ALA   A 1 226 ? -17.83231 -14.68948 5.83995   1.000 31.06785  ? 231  ALA   A CA   1 
ATOM   1546 C  C    . ALA   A 1 226 ? -16.96420 -13.94250 4.84803   1.000 28.25794  ? 231  ALA   A C    1 
ATOM   1547 O  O    . ALA   A 1 226 ? -17.00508 -12.71249 4.78911   1.000 29.68907  ? 231  ALA   A O    1 
ATOM   1548 C  CB   . ALA   A 1 226 ? -19.28830 -14.72631 5.31989   1.000 26.24027  ? 231  ALA   A CB   1 
ATOM   1549 N  N    . ALA   A 1 227 ? -16.20625 -14.68353 4.05101   1.000 26.48169  ? 232  ALA   A N    1 
ATOM   1550 C  CA   . ALA   A 1 227 ? -15.41115 -14.09154 2.99008   1.000 29.17371  ? 232  ALA   A CA   1 
ATOM   1551 C  C    . ALA   A 1 227 ? -16.10512 -14.32338 1.65604   1.000 22.77691  ? 232  ALA   A C    1 
ATOM   1552 O  O    . ALA   A 1 227 ? -16.63222 -15.41032 1.40395   1.000 24.46677  ? 232  ALA   A O    1 
ATOM   1553 C  CB   . ALA   A 1 227 ? -14.00521 -14.68767 2.96510   1.000 19.75793  ? 232  ALA   A CB   1 
ATOM   1554 N  N    . THR   A 1 228 ? -16.09999 -13.30733 0.79910   1.000 25.71787  ? 233  THR   A N    1 
ATOM   1555 C  CA   . THR   A 1 228 ? -16.59595 -13.45720 -0.56393  1.000 28.05591  ? 233  THR   A CA   1 
ATOM   1556 C  C    . THR   A 1 228 ? -15.48888 -13.10624 -1.56286  1.000 29.23880  ? 233  THR   A C    1 
ATOM   1557 O  O    . THR   A 1 228 ? -14.57582 -12.32735 -1.25978  1.000 25.08165  ? 233  THR   A O    1 
ATOM   1558 C  CB   . THR   A 1 228 ? -17.85486 -12.58706 -0.79492  1.000 29.84562  ? 233  THR   A CB   1 
ATOM   1559 O  OG1  . THR   A 1 228 ? -17.68076 -11.31912 -0.15583  1.000 29.72168  ? 233  THR   A OG1  1 
ATOM   1560 C  CG2  . THR   A 1 228 ? -19.08795 -13.25198 -0.18701  1.000 25.02675  ? 233  THR   A CG2  1 
ATOM   1561 N  N    . LEU   A 1 229 ? -15.55889 -13.71116 -2.75590  1.000 24.83803  ? 234  LEU   A N    1 
ATOM   1562 C  CA   . LEU   A 1 229 ? -14.52784 -13.51520 -3.77385  1.000 24.71387  ? 234  LEU   A CA   1 
ATOM   1563 C  C    . LEU   A 1 229 ? -14.64068 -12.16914 -4.46777  1.000 28.39576  ? 234  LEU   A C    1 
ATOM   1564 O  O    . LEU   A 1 229 ? -14.36162 -12.05109 -5.65575  1.000 27.55265  ? 234  LEU   A O    1 
ATOM   1565 C  CB   . LEU   A 1 229 ? -14.55791 -14.66713 -4.77892  1.000 21.68790  ? 234  LEU   A CB   1 
ATOM   1566 C  CG   . LEU   A 1 229 ? -14.20307 -16.01221 -4.10700  1.000 24.17133  ? 234  LEU   A CG   1 
ATOM   1567 C  CD1  . LEU   A 1 229 ? -14.10514 -17.14215 -5.09406  1.000 22.75355  ? 234  LEU   A CD1  1 
ATOM   1568 C  CD2  . LEU   A 1 229 ? -12.89908 -15.89338 -3.30294  1.000 25.22958  ? 234  LEU   A CD2  1 
ATOM   1569 N  N    . ASP   A 1 230 ? -15.04061 -11.14115 -3.72072  1.000 29.03863  ? 235  ASP   A N    1 
ATOM   1570 C  CA   . ASP   A 1 230 ? -15.01046 -9.75513  -4.15263  1.000 33.30381  ? 235  ASP   A CA   1 
ATOM   1571 C  C    . ASP   A 1 230 ? -14.10441 -8.94127  -3.22955  1.000 33.16977  ? 235  ASP   A C    1 
ATOM   1572 O  O    . ASP   A 1 230 ? -14.34530 -7.75226  -2.99348  1.000 30.16564  ? 235  ASP   A O    1 
ATOM   1573 C  CB   . ASP   A 1 230 ? -16.42440 -9.15499  -4.19065  1.000 24.41925  ? 235  ASP   A CB   1 
ATOM   1574 C  CG   . ASP   A 1 230 ? -17.10345 -9.22100  -2.84668  1.000 31.31121  ? 235  ASP   A CG   1 
ATOM   1575 O  OD1  . ASP   A 1 230 ? -16.47254 -9.74713  -1.88369  1.000 31.71156  ? 235  ASP   A OD1  1 
ATOM   1576 O  OD2  . ASP   A 1 230 ? -18.27041 -8.77590  -2.74169  1.000 35.65799  ? 235  ASP   A OD2  1 
ATOM   1577 N  N    . ASN   A 1 231 ? -13.07349 -9.58541  -2.67555  1.000 30.99642  ? 236  ASN   A N    1 
ATOM   1578 C  CA   . ASN   A 1 231 ? -12.11046 -8.91956  -1.78147  1.000 27.29623  ? 236  ASN   A CA   1 
ATOM   1579 C  C    . ASN   A 1 231 ? -12.76846 -8.38757  -0.51746  1.000 28.83615  ? 236  ASN   A C    1 
ATOM   1580 O  O    . ASN   A 1 231 ? -12.42937 -7.30664  -0.03638  1.000 30.69281  ? 236  ASN   A O    1 
ATOM   1581 C  CB   . ASN   A 1 231 ? -11.38433 -7.78158  -2.49637  1.000 29.25194  ? 236  ASN   A CB   1 
ATOM   1582 C  CG   . ASN   A 1 231 ? -10.98031 -8.14453  -3.88538  1.000 32.39087  ? 236  ASN   A CG   1 
ATOM   1583 O  OD1  . ASN   A 1 231 ? -10.06838 -8.95561  -4.08439  1.000 35.36544  ? 236  ASN   A OD1  1 
ATOM   1584 N  ND2  . ASN   A 1 231 ? -11.64521 -7.54741  -4.87237  1.000 31.50950  ? 236  ASN   A ND2  1 
ATOM   1585 N  N    . THR   A 1 232 ? -13.69256 -9.15052  0.05946   1.000 28.46888  ? 237  THR   A N    1 
ATOM   1586 C  CA   . THR   A 1 232 ? -14.43955 -8.61952  1.18646   1.000 26.37066  ? 237  THR   A CA   1 
ATOM   1587 C  C    . THR   A 1 232 ? -14.66469 -9.66656  2.26739   1.000 28.71061  ? 237  THR   A C    1 
ATOM   1588 O  O    . THR   A 1 232 ? -14.99779 -10.81851 1.96930   1.000 28.29300  ? 237  THR   A O    1 
ATOM   1589 C  CB   . THR   A 1 232 ? -15.81248 -8.08636  0.74144   1.000 33.51074  ? 237  THR   A CB   1 
ATOM   1590 O  OG1  . THR   A 1 232 ? -15.65535 -7.19430  -0.36250  1.000 34.98838  ? 237  THR   A OG1  1 
ATOM   1591 C  CG2  . THR   A 1 232 ? -16.47645 -7.37236  1.88546   1.000 34.67835  ? 237  THR   A CG2  1 
ATOM   1592 N  N    . LEU   A 1 233 ? -14.48970 -9.24266  3.51942   1.000 26.65838  ? 238  LEU   A N    1 
ATOM   1593 C  CA   A LEU   A 1 233 ? -14.91082 -10.01069 4.68336   0.746 28.77692  ? 238  LEU   A CA   1 
ATOM   1594 C  CA   B LEU   A 1 233 ? -14.90282 -10.00169 4.69436   0.254 28.78008  ? 238  LEU   A CA   1 
ATOM   1595 C  C    . LEU   A 1 233 ? -16.07677 -9.29462  5.35336   1.000 29.96110  ? 238  LEU   A C    1 
ATOM   1596 O  O    . LEU   A 1 233 ? -16.11065 -8.06362  5.41943   1.000 30.73454  ? 238  LEU   A O    1 
ATOM   1597 C  CB   A LEU   A 1 233 ? -13.76187 -10.18287 5.68439   0.746 28.44818  ? 238  LEU   A CB   1 
ATOM   1598 C  CB   B LEU   A 1 233 ? -13.77287 -10.13987 5.72039   0.254 28.49461  ? 238  LEU   A CB   1 
ATOM   1599 C  CG   A LEU   A 1 233 ? -12.77996 -11.29194 5.30736   0.746 29.79942  ? 238  LEU   A CG   1 
ATOM   1600 C  CG   B LEU   A 1 233 ? -12.71196 -11.21496 5.51036   0.254 29.68308  ? 238  LEU   A CG   1 
ATOM   1601 C  CD1  A LEU   A 1 233 ? -11.42096 -10.98011 5.89943   0.746 30.79065  ? 238  LEU   A CD1  1 
ATOM   1602 C  CD1  B LEU   A 1 233 ? -11.78488 -10.78398 4.41443   0.254 29.48510  ? 238  LEU   A CD1  1 
ATOM   1603 C  CD2  A LEU   A 1 233 ? -13.29411 -12.65192 5.79725   0.746 25.21188  ? 238  LEU   A CD2  1 
ATOM   1604 C  CD2  B LEU   A 1 233 ? -11.94304 -11.46911 6.79938   0.254 28.33700  ? 238  LEU   A CD2  1 
ATOM   1605 N  N    . LYS   A 1 234 ? -17.01987 -10.06456 5.87227   1.000 29.98122  ? 239  LYS   A N    1 
ATOM   1606 C  CA   . LYS   A 1 234 ? -18.18983 -9.45649  6.48227   1.000 35.64081  ? 239  LYS   A CA   1 
ATOM   1607 C  C    . LYS   A 1 234 ? -18.51495 -10.17454 7.77421   1.000 30.97371  ? 239  LYS   A C    1 
ATOM   1608 O  O    . LYS   A 1 234 ? -18.53307 -11.40654 7.81113   1.000 33.66829  ? 239  LYS   A O    1 
ATOM   1609 C  CB   . LYS   A 1 234 ? -19.38980 -9.48231  5.52322   1.000 31.11139  ? 239  LYS   A CB   1 
ATOM   1610 C  CG   . LYS   A 1 234 ? -19.29865 -8.41725  4.45229   1.000 32.98861  ? 239  LYS   A CG   1 
ATOM   1611 C  CD   . LYS   A 1 234 ? -20.54262 -8.42507  3.53924   1.000 43.45794  ? 239  LYS   A CD   1 
ATOM   1612 C  CE   . LYS   A 1 234 ? -20.53146 -7.20701  2.61232   1.000 41.92429  ? 239  LYS   A CE   1 
ATOM   1613 N  NZ   . LYS   A 1 234 ? -21.31044 -7.45686  1.35727   1.000 47.07905  ? 239  LYS   A NZ   1 
ATOM   1614 N  N    . LEU   A 1 235 ? -18.76491 -9.39058  8.82125   1.000 32.61095  ? 240  LEU   A N    1 
ATOM   1615 C  CA   . LEU   A 1 235 ? -19.26501 -9.89061  10.08420  1.000 32.52793  ? 240  LEU   A CA   1 
ATOM   1616 C  C    . LEU   A 1 235 ? -20.78500 -9.74546  10.12315  1.000 37.96257  ? 240  LEU   A C    1 
ATOM   1617 O  O    . LEU   A 1 235 ? -21.31688 -8.64240  9.94520   1.000 36.80229  ? 240  LEU   A O    1 
ATOM   1618 C  CB   . LEU   A 1 235 ? -18.61698 -9.13174  11.24727  1.000 35.80175  ? 240  LEU   A CB   1 
ATOM   1619 C  CG   . LEU   A 1 235 ? -18.95509 -9.67980  12.63722  1.000 37.64936  ? 240  LEU   A CG   1 
ATOM   1620 C  CD1  . LEU   A 1 235 ? -18.35723 -11.05687 12.85516  1.000 35.66896  ? 240  LEU   A CD1  1 
ATOM   1621 C  CD2  . LEU   A 1 235 ? -18.46403 -8.70591  13.69830  1.000 40.59405  ? 240  LEU   A CD2  1 
ATOM   1622 N  N    . TRP   A 1 236 ? -21.47111 -10.85341 10.38605  1.000 35.33468  ? 241  TRP   A N    1 
ATOM   1623 C  CA   . TRP   A 1 236 ? -22.91112 -10.96626 10.22199  1.000 42.55343  ? 241  TRP   A CA   1 
ATOM   1624 C  C    . TRP   A 1 236 ? -23.55920 -11.28128 11.55795  1.000 40.49298  ? 241  TRP   A C    1 
ATOM   1625 O  O    . TRP   A 1 236 ? -23.11432 -12.19137 12.27191  1.000 36.11513  ? 241  TRP   A O    1 
ATOM   1626 C  CB   . TRP   A 1 236 ? -23.26719 -12.07216 9.21891   1.000 41.18086  ? 241  TRP   A CB   1 
ATOM   1627 C  CG   . TRP   A 1 236 ? -23.17609 -11.66708 7.78094   1.000 46.34922  ? 241  TRP   A CG   1 
ATOM   1628 C  CD1  . TRP   A 1 236 ? -22.05206 -11.61414 7.00598   1.000 45.74313  ? 241  TRP   A CD1  1 
ATOM   1629 C  CD2  . TRP   A 1 236 ? -24.26402 -11.27492 6.93492   1.000 48.27026  ? 241  TRP   A CD2  1 
ATOM   1630 N  NE1  . TRP   A 1 236 ? -22.37097 -11.19503 5.73500   1.000 40.15758  ? 241  TRP   A NE1  1 
ATOM   1631 C  CE2  . TRP   A 1 236 ? -23.72395 -10.98290 5.66596   1.000 48.74026  ? 241  TRP   A CE2  1 
ATOM   1632 C  CE3  . TRP   A 1 236 ? -25.64602 -11.14180 7.12988   1.000 52.43796  ? 241  TRP   A CE3  1 
ATOM   1633 C  CZ2  . TRP   A 1 236 ? -24.51987 -10.56475 4.59396   1.000 54.06407  ? 241  TRP   A CZ2  1 
ATOM   1634 C  CZ3  . TRP   A 1 236 ? -26.43494 -10.72866 6.06587   1.000 52.37687  ? 241  TRP   A CZ3  1 
ATOM   1635 C  CH2  . TRP   A 1 236 ? -25.86786 -10.44163 4.81591   1.000 54.79576  ? 241  TRP   A CH2  1 
ATOM   1636 N  N    . ASP   A 1 237 ? -24.61714 -10.54120 11.88395  1.000 43.21681  ? 242  ASP   A N    1 
ATOM   1637 C  CA   . ASP   A 1 237 ? -25.59922 -11.01117 12.85989  1.000 44.94397  ? 242  ASP   A CA   1 
ATOM   1638 C  C    . ASP   A 1 237 ? -26.53629 -11.95303 12.11279  1.000 47.17818  ? 242  ASP   A C    1 
ATOM   1639 O  O    . ASP   A 1 237 ? -27.47422 -11.51190 11.44478  1.000 46.01189  ? 242  ASP   A O    1 
ATOM   1640 C  CB   . ASP   A 1 237 ? -26.36313 -9.84713  13.47793  1.000 50.05615  ? 242  ASP   A CB   1 
ATOM   1641 C  CG   . ASP   A 1 237 ? -27.28722 -10.28511 14.61187  1.000 53.60910  ? 242  ASP   A CG   1 
ATOM   1642 O  OD1  . ASP   A 1 237 ? -27.60334 -11.49709 14.72078  1.000 50.78492  ? 242  ASP   A OD1  1 
ATOM   1643 O  OD2  . ASP   A 1 237 ? -27.69317 -9.41312  15.40791  1.000 62.75430  ? 242  ASP   A OD2  1 
ATOM   1644 N  N    . TYR   A 1 238 ? -26.27342 -13.25806 12.20172  1.000 46.98257  ? 243  TYR   A N    1 
ATOM   1645 C  CA   . TYR   A 1 238 ? -27.03948 -14.19293 11.38463  1.000 50.02706  ? 243  TYR   A CA   1 
ATOM   1646 C  C    . TYR   A 1 238 ? -28.45152 -14.39183 11.92557  1.000 54.41357  ? 243  TYR   A C    1 
ATOM   1647 O  O    . TYR   A 1 238 ? -29.36452 -14.72769 11.16051  1.000 57.16952  ? 243  TYR   A O    1 
ATOM   1648 C  CB   . TYR   A 1 238 ? -26.31560 -15.53300 11.27257  1.000 41.94626  ? 243  TYR   A CB   1 
ATOM   1649 C  CG   . TYR   A 1 238 ? -26.11872 -16.21610 12.58654  1.000 44.00135  ? 243  TYR   A CG   1 
ATOM   1650 C  CD1  . TYR   A 1 238 ? -27.10582 -17.02704 13.12245  1.000 45.44655  ? 243  TYR   A CD1  1 
ATOM   1651 C  CD2  . TYR   A 1 238 ? -24.94873 -16.03526 13.31060  1.000 45.36466  ? 243  TYR   A CD2  1 
ATOM   1652 C  CE1  . TYR   A 1 238 ? -26.93293 -17.65313 14.34142  1.000 48.70810  ? 243  TYR   A CE1  1 
ATOM   1653 C  CE2  . TYR   A 1 238 ? -24.76184 -16.65235 14.52956  1.000 47.68480  ? 243  TYR   A CE2  1 
ATOM   1654 C  CZ   . TYR   A 1 238 ? -25.75693 -17.46229 15.04247  1.000 52.31310  ? 243  TYR   A CZ   1 
ATOM   1655 O  OH   . TYR   A 1 238 ? -25.56504 -18.08938 16.25344  1.000 55.17854  ? 243  TYR   A OH   1 
ATOM   1656 N  N    . SER   A 1 239 ? -28.66055 -14.19589 13.22857  1.000 53.57380  ? 244  SER   A N    1 
ATOM   1657 C  CA   . SER   A 1 239 ? -30.02856 -14.14279 13.73952  1.000 52.71267  ? 244  SER   A CA   1 
ATOM   1658 C  C    . SER   A 1 239 ? -30.82943 -13.06567 13.01456  1.000 55.27265  ? 244  SER   A C    1 
ATOM   1659 O  O    . SER   A 1 239 ? -31.85343 -13.35053 12.37850  1.000 56.78565  ? 244  SER   A O    1 
ATOM   1660 C  CB   . SER   A 1 239 ? -30.02559 -13.89589 15.24954  1.000 52.18335  ? 244  SER   A CB   1 
ATOM   1661 O  OG   . SER   A 1 239 ? -29.69674 -15.08296 15.95047  1.000 63.95605  ? 244  SER   A OG   1 
ATOM   1662 N  N    . LYS   A 1 240 ? -30.36431 -11.82272 13.07565  1.000 54.45043  ? 245  LYS   A N    1 
ATOM   1663 C  CA   . LYS   A 1 240 ? -31.07918 -10.71861 12.45470  1.000 54.81854  ? 245  LYS   A CA   1 
ATOM   1664 C  C    . LYS   A 1 240 ? -30.80611 -10.58854 10.96272  1.000 57.43401  ? 245  LYS   A C    1 
ATOM   1665 O  O    . LYS   A 1 240 ? -31.38600 -9.70244  10.32375  1.000 57.96467  ? 245  LYS   A O    1 
ATOM   1666 C  CB   . LYS   A 1 240 ? -30.73308 -9.40069  13.16579  1.000 60.11706  ? 245  LYS   A CB   1 
ATOM   1667 C  CG   . LYS   A 1 240 ? -31.34712 -9.28471  14.55678  1.000 64.85245  ? 245  LYS   A CG   1 
ATOM   1668 C  CD   . LYS   A 1 240 ? -32.78317 -9.80457  14.52069  1.000 74.43149  ? 245  LYS   A CD   1 
ATOM   1669 C  CE   . LYS   A 1 240 ? -33.54619 -9.50658  15.80068  1.000 76.82208  ? 245  LYS   A CE   1 
ATOM   1670 N  NZ   . LYS   A 1 240 ? -34.98115 -9.18842  15.50064  1.000 74.40303  ? 245  LYS   A NZ   1 
ATOM   1671 N  N    . GLY   A 1 241 ? -29.95117 -11.43459 10.39069  1.000 58.50877  ? 246  GLY   A N    1 
ATOM   1672 C  CA   . GLY   A 1 241 ? -29.58310 -11.29054 8.98472   1.000 45.17269  ? 246  GLY   A CA   1 
ATOM   1673 C  C    . GLY   A 1 241 ? -29.01196 -9.93257  8.63482   1.000 48.04839  ? 246  GLY   A C    1 
ATOM   1674 O  O    . GLY   A 1 241 ? -29.31686 -9.38247  7.56485   1.000 53.29166  ? 246  GLY   A O    1 
ATOM   1675 N  N    . LYS   A 1 242 ? -28.18194 -9.37370  9.51289   1.000 50.80513  ? 247  LYS   A N    1 
ATOM   1676 C  CA   . LYS   A 1 242 ? -27.59780 -8.05775  9.30200   1.000 52.01191  ? 247  LYS   A CA   1 
ATOM   1677 C  C    . LYS   A 1 242 ? -26.08481 -8.17589  9.23105   1.000 50.85290  ? 247  LYS   A C    1 
ATOM   1678 O  O    . LYS   A 1 242 ? -25.46991 -8.90300  10.01902  1.000 44.44173  ? 247  LYS   A O    1 
ATOM   1679 C  CB   . LYS   A 1 242 ? -27.98875 -7.08178  10.42904  1.000 50.69182  ? 247  LYS   A CB   1 
ATOM   1680 C  CG   . LYS   A 1 242 ? -29.46877 -7.13866  10.79898  1.000 65.40949  ? 247  LYS   A CG   1 
ATOM   1681 C  CD   . LYS   A 1 242 ? -30.03865 -5.75463  11.12905  1.000 76.83644  ? 247  LYS   A CD   1 
ATOM   1682 C  CE   . LYS   A 1 242 ? -31.57065 -5.77648  11.17299  1.000 75.29173  ? 247  LYS   A CE   1 
ATOM   1683 N  NZ   . LYS   A 1 242 ? -32.15653 -4.43444  11.45205  1.000 81.28093  ? 247  LYS   A NZ   1 
ATOM   1684 N  N    . CYS   A 1 243 ? -25.49771 -7.47089  8.27311   1.000 49.54006  ? 248  CYS   A N    1 
ATOM   1685 C  CA   . CYS   A 1 243 ? -24.05269 -7.33402  8.22118   1.000 47.72297  ? 248  CYS   A CA   1 
ATOM   1686 C  C    . CYS   A 1 243 ? -23.64561 -6.18612  9.13226   1.000 42.68532  ? 248  CYS   A C    1 
ATOM   1687 O  O    . CYS   A 1 243 ? -24.05549 -5.04607  8.90732   1.000 49.43224  ? 248  CYS   A O    1 
ATOM   1688 C  CB   . CYS   A 1 243 ? -23.58361 -7.09498  6.78721   1.000 47.85302  ? 248  CYS   A CB   1 
ATOM   1689 S  SG   . CYS   A 1 243 ? -21.88155 -6.50114  6.65431   1.000 45.50052  ? 248  CYS   A SG   1 
ATOM   1690 N  N    . LEU   A 1 244 ? -22.83968 -6.48426  10.15128  1.000 38.38662  ? 249  LEU   A N    1 
ATOM   1691 C  CA   . LEU   A 1 244 ? -22.40662 -5.50137  11.14235  1.000 37.33088  ? 249  LEU   A CA   1 
ATOM   1692 C  C    . LEU   A 1 244 ? -21.07954 -4.83048  10.79545  1.000 41.37696  ? 249  LEU   A C    1 
ATOM   1693 O  O    . LEU   A 1 244 ? -20.87244 -3.65952  11.13453  1.000 42.49483  ? 249  LEU   A O    1 
ATOM   1694 C  CB   . LEU   A 1 244 ? -22.26574 -6.16447  12.51032  1.000 36.72764  ? 249  LEU   A CB   1 
ATOM   1695 C  CG   . LEU   A 1 244 ? -23.46684 -6.97438  12.99622  1.000 43.17692  ? 249  LEU   A CG   1 
ATOM   1696 C  CD1  . LEU   A 1 244 ? -23.14096 -7.78749  14.25818  1.000 42.06315  ? 249  LEU   A CD1  1 
ATOM   1697 C  CD2  . LEU   A 1 244 ? -24.63676 -6.04628  13.24324  1.000 38.84093  ? 249  LEU   A CD2  1 
ATOM   1698 N  N    . LYS   A 1 245 ? -20.15959 -5.54653  10.16744  1.000 35.32323  ? 250  LYS   A N    1 
ATOM   1699 C  CA   . LYS   A 1 245 ? -18.83353 -5.02564  9.89152   1.000 36.37809  ? 250  LYS   A CA   1 
ATOM   1700 C  C    . LYS   A 1 245 ? -18.38553 -5.53460  8.53450   1.000 36.44557  ? 250  LYS   A C    1 
ATOM   1701 O  O    . LYS   A 1 245 ? -18.71562 -6.65754  8.14242   1.000 31.91877  ? 250  LYS   A O    1 
ATOM   1702 C  CB   . LYS   A 1 245 ? -17.81261 -5.44780  10.97253  1.000 35.22922  ? 250  LYS   A CB   1 
ATOM   1703 C  CG   . LYS   A 1 245 ? -18.19463 -5.05586  12.39554  1.000 37.43145  ? 250  LYS   A CG   1 
ATOM   1704 C  CD   . LYS   A 1 245 ? -18.03349 -3.55589  12.65264  1.000 38.78508  ? 250  LYS   A CD   1 
ATOM   1705 C  CE   . LYS   A 1 245 ? -18.42151 -3.23294  14.09865  1.000 49.07000  ? 250  LYS   A CE   1 
ATOM   1706 N  NZ   . LYS   A 1 245 ? -18.32938 -1.77097  14.40974  1.000 52.37259  ? 250  LYS   A NZ   1 
ATOM   1707 N  N    . THR   A 1 246 ? -17.62942 -4.69162  7.83059   1.000 35.16472  ? 251  THR   A N    1 
ATOM   1708 C  CA   . THR   A 1 246 ? -17.05240 -5.00960  6.53159   1.000 39.99768  ? 251  THR   A CA   1 
ATOM   1709 C  C    . THR   A 1 246 ? -15.56337 -4.70575  6.57966   1.000 36.31579  ? 251  THR   A C    1 
ATOM   1710 O  O    . THR   A 1 246 ? -15.17728 -3.60981  6.98175   1.000 38.41107  ? 251  THR   A O    1 
ATOM   1711 C  CB   . THR   A 1 246 ? -17.72828 -4.19446  5.41561   1.000 34.81062  ? 251  THR   A CB   1 
ATOM   1712 O  OG1  . THR   A 1 246 ? -19.10131 -4.58832  5.30854   1.000 42.12215  ? 251  THR   A OG1  1 
ATOM   1713 C  CG2  . THR   A 1 246 ? -17.03725 -4.42645  4.09463   1.000 38.91742  ? 251  THR   A CG2  1 
ATOM   1714 N  N    . TYR   A 1 247 ? -14.73145 -5.67180  6.18163   1.000 36.25582  ? 252  TYR   A N    1 
ATOM   1715 C  CA   . TYR   A 1 247 ? -13.28043 -5.50594  6.16570   1.000 29.49169  ? 252  TYR   A CA   1 
ATOM   1716 C  C    . TYR   A 1 247 ? -12.77739 -5.65790  4.73771   1.000 32.41133  ? 252  TYR   A C    1 
ATOM   1717 O  O    . TYR   A 1 247 ? -13.11646 -6.62983  4.05364   1.000 33.63518  ? 252  TYR   A O    1 
ATOM   1718 C  CB   . TYR   A 1 247 ? -12.58457 -6.52007  7.09766   1.000 27.89372  ? 252  TYR   A CB   1 
ATOM   1719 C  CG   . TYR   A 1 247 ? -13.25863 -6.62909  8.44963   1.000 30.38609  ? 252  TYR   A CG   1 
ATOM   1720 C  CD1  . TYR   A 1 247 ? -12.92459 -5.76019  9.48970   1.000 30.54792  ? 252  TYR   A CD1  1 
ATOM   1721 C  CD2  . TYR   A 1 247 ? -14.24173 -7.58201  8.67753   1.000 30.23105  ? 252  TYR   A CD2  1 
ATOM   1722 C  CE1  . TYR   A 1 247 ? -13.55264 -5.83720  10.73067  1.000 28.16459  ? 252  TYR   A CE1  1 
ATOM   1723 C  CE2  . TYR   A 1 247 ? -14.87979 -7.66902  9.91150   1.000 32.71078  ? 252  TYR   A CE2  1 
ATOM   1724 C  CZ   . TYR   A 1 247 ? -14.52274 -6.79112  10.93757  1.000 34.18705  ? 252  TYR   A CZ   1 
ATOM   1725 O  OH   . TYR   A 1 247 ? -15.15680 -6.88214  12.15854  1.000 32.03090  ? 252  TYR   A OH   1 
ATOM   1726 N  N    . THR   A 1 248 ? -11.96229 -4.70395  4.29780   1.000 29.85348  ? 253  THR   A N    1 
ATOM   1727 C  CA   . THR   A 1 248 ? -11.42923 -4.68492  2.95382   1.000 35.73932  ? 253  THR   A CA   1 
ATOM   1728 C  C    . THR   A 1 248 ? -9.98719  -4.20606  2.99991   1.000 30.40900  ? 253  THR   A C    1 
ATOM   1729 O  O    . THR   A 1 248 ? -9.45219  -3.86818  4.05895   1.000 33.24339  ? 253  THR   A O    1 
ATOM   1730 C  CB   . THR   A 1 248 ? -12.25211 -3.75878  2.03785   1.000 35.64269  ? 253  THR   A CB   1 
ATOM   1731 O  OG1  . THR   A 1 248 ? -12.28700 -2.44682  2.62393   1.000 39.67791  ? 253  THR   A OG1  1 
ATOM   1732 C  CG2  . THR   A 1 248 ? -13.66215 -4.26864  1.88776   1.000 34.20309  ? 253  THR   A CG2  1 
ATOM   1733 N  N    . GLY   A 1 249 ? -9.38913  -4.11205  1.80894   1.000 29.29858  ? 254  GLY   A N    1 
ATOM   1734 C  CA   . GLY   A 1 249 ? -8.00009  -3.74917  1.62501   1.000 33.62892  ? 254  GLY   A CA   1 
ATOM   1735 C  C    . GLY   A 1 249 ? -7.13418  -4.87922  1.09397   1.000 31.93775  ? 254  GLY   A C    1 
ATOM   1736 O  O    . GLY   A 1 249 ? -6.11413  -4.61028  0.43503   1.000 32.33211  ? 254  GLY   A O    1 
ATOM   1737 N  N    . HIS   A 1 250 ? -7.51031  -6.13820  1.37188   1.000 30.75542  ? 255  HIS   A N    1 
ATOM   1738 C  CA   . HIS   A 1 250 ? -6.74041  -7.28225  0.90384   1.000 32.78381  ? 255  HIS   A CA   1 
ATOM   1739 C  C    . HIS   A 1 250 ? -7.19739  -7.70112  -0.49721  1.000 35.25373  ? 255  HIS   A C    1 
ATOM   1740 O  O    . HIS   A 1 250 ? -8.11632  -7.11499  -1.07720  1.000 33.89252  ? 255  HIS   A O    1 
ATOM   1741 C  CB   . HIS   A 1 250 ? -6.87756  -8.43630  1.88776   1.000 28.58981  ? 255  HIS   A CB   1 
ATOM   1742 C  CG   . HIS   A 1 250 ? -8.27461  -8.94717  1.99567   1.000 33.05208  ? 255  HIS   A CG   1 
ATOM   1743 N  ND1  . HIS   A 1 250 ? -9.34754  -8.12108  2.26569   1.000 30.69153  ? 255  HIS   A ND1  1 
ATOM   1744 C  CD2  . HIS   A 1 250 ? -8.77473  -10.19911 1.88658   1.000 32.69527  ? 255  HIS   A CD2  1 
ATOM   1745 C  CE1  . HIS   A 1 250 ? -10.45161 -8.84398  2.31060   1.000 32.81303  ? 255  HIS   A CE1  1 
ATOM   1746 N  NE2  . HIS   A 1 250 ? -10.13173 -10.10899 2.08753   1.000 33.52855  ? 255  HIS   A NE2  1 
ATOM   1747 N  N    . LYS   A 1 251 ? -6.56048  -8.74414  -1.04525  1.000 29.79633  ? 256  LYS   A N    1 
ATOM   1748 C  CA   . LYS   A 1 251 ? -6.90848  -9.31303  -2.34930  1.000 29.71409  ? 256  LYS   A CA   1 
ATOM   1749 C  C    . LYS   A 1 251 ? -7.51662  -10.70198 -2.15441  1.000 33.20339  ? 256  LYS   A C    1 
ATOM   1750 O  O    . LYS   A 1 251 ? -6.88373  -11.60108 -1.58244  1.000 26.85974  ? 256  LYS   A O    1 
ATOM   1751 C  CB   . LYS   A 1 251 ? -5.68445  -9.40109  -3.27126  1.000 33.74186  ? 256  LYS   A CB   1 
ATOM   1752 C  CG   . LYS   A 1 251 ? -4.95732  -8.09615  -3.43815  1.000 46.73711  ? 256  LYS   A CG   1 
ATOM   1753 C  CD   . LYS   A 1 251 ? -5.69519  -7.14002  -4.39011  1.000 58.43157  ? 256  LYS   A CD   1 
ATOM   1754 C  CE   . LYS   A 1 251 ? -5.06206  -5.73908  -4.38500  1.000 60.00284  ? 256  LYS   A CE   1 
ATOM   1755 N  NZ   . LYS   A 1 251 ? -6.02397  -4.70402  -3.89897  1.000 61.20650  ? 256  LYS   A NZ   1 
ATOM   1756 N  N    . ASN   A 1 252 ? -8.73462  -10.89183 -2.64147  1.000 26.98119  ? 257  ASN   A N    1 
ATOM   1757 C  CA   . ASN   A 1 252 ? -9.34076  -12.20778 -2.52357  1.000 26.97729  ? 257  ASN   A CA   1 
ATOM   1758 C  C    . ASN   A 1 252 ? -10.44373 -12.30961 -3.58062  1.000 26.57995  ? 257  ASN   A C    1 
ATOM   1759 O  O    . ASN   A 1 252 ? -11.60571 -12.00251 -3.30964  1.000 26.41342  ? 257  ASN   A O    1 
ATOM   1760 C  CB   . ASN   A 1 252 ? -9.86983  -12.45082 -1.12861  1.000 25.67925  ? 257  ASN   A CB   1 
ATOM   1761 C  CG   . ASN   A 1 252 ? -10.27298 -13.88579 -0.91371  1.000 24.22600  ? 257  ASN   A CG   1 
ATOM   1762 O  OD1  . ASN   A 1 252 ? -9.88204  -14.77778 -1.67475  1.000 26.77499  ? 257  ASN   A OD1  1 
ATOM   1763 N  ND2  . ASN   A 1 252 ? -11.06504 -14.12178 0.11624   1.000 23.39636  ? 257  ASN   A ND2  1 
ATOM   1764 N  N    . GLU   A 1 253 ? -10.05672 -12.75857 -4.76263  1.000 21.80071  ? 258  GLU   A N    1 
ATOM   1765 C  CA   . GLU   A 1 253 ? -10.97871 -13.00441 -5.84568  1.000 27.05828  ? 258  GLU   A CA   1 
ATOM   1766 C  C    . GLU   A 1 253 ? -10.91483 -14.42438 -6.36677  1.000 26.79852  ? 258  GLU   A C    1 
ATOM   1767 O  O    . GLU   A 1 253 ? -11.72083 -14.77425 -7.22382  1.000 27.67322  ? 258  GLU   A O    1 
ATOM   1768 C  CB   . GLU   A 1 253 ? -10.71857 -12.03336 -7.01061  1.000 26.69728  ? 258  GLU   A CB   1 
ATOM   1769 C  CG   . GLU   A 1 253 ? -10.98444 -10.59836 -6.62753  1.000 32.60811  ? 258  GLU   A CG   1 
ATOM   1770 C  CD   . GLU   A 1 253 ? -10.74630 -9.60731  -7.78046  1.000 40.27068  ? 258  GLU   A CD   1 
ATOM   1771 O  OE1  . GLU   A 1 253 ? -9.94930  -9.90933  -8.70645  1.000 37.85672  ? 258  GLU   A OE1  1 
ATOM   1772 O  OE2  . GLU   A 1 253 ? -11.34020 -8.51826  -7.73642  1.000 34.49652  ? 258  GLU   A OE2  1 
ATOM   1773 N  N    . LYS   A 1 254 ? -10.00492 -15.23750 -5.89179  1.000 27.15265  ? 259  LYS   A N    1 
ATOM   1774 C  CA   . LYS   A 1 254 ? -9.91903  -16.54247 -6.51387  1.000 25.86289  ? 259  LYS   A CA   1 
ATOM   1775 C  C    . LYS   A 1 254 ? -9.88618  -17.69554 -5.52594  1.000 29.72335  ? 259  LYS   A C    1 
ATOM   1776 O  O    . LYS   A 1 254 ? -10.56226 -18.70446 -5.75503  1.000 29.58821  ? 259  LYS   A O    1 
ATOM   1777 C  CB   . LYS   A 1 254 ? -8.68000  -16.59554 -7.41982  1.000 31.78033  ? 259  LYS   A CB   1 
ATOM   1778 C  CG   . LYS   A 1 254 ? -8.50110  -17.93951 -8.14990  1.000 31.84185  ? 259  LYS   A CG   1 
ATOM   1779 C  CD   . LYS   A 1 254 ? -7.27705  -17.85357 -9.09385  1.000 35.69587  ? 259  LYS   A CD   1 
ATOM   1780 C  CE   . LYS   A 1 254 ? -7.18913  -19.01051 -10.07992 1.000 44.31544  ? 259  LYS   A CE   1 
ATOM   1781 N  NZ   . LYS   A 1 254 ? -6.66928  -20.26860 -9.46998  1.000 48.08143  ? 259  LYS   A NZ   1 
ATOM   1782 N  N    . TYR   A 1 255 ? -9.11321  -17.58968 -4.44790  1.000 26.45718  ? 260  TYR   A N    1 
ATOM   1783 C  CA   . TYR   A 1 255 ? -8.86635  -18.71376 -3.54996  1.000 26.93542  ? 260  TYR   A CA   1 
ATOM   1784 C  C    . TYR   A 1 255 ? -9.77439  -18.67375 -2.32899  1.000 27.62957  ? 260  TYR   A C    1 
ATOM   1785 O  O    . TYR   A 1 255 ? -10.21331 -17.61173 -1.88594  1.000 25.36125  ? 260  TYR   A O    1 
ATOM   1786 C  CB   . TYR   A 1 255 ? -7.41237  -18.72693 -3.08691  1.000 24.03781  ? 260  TYR   A CB   1 
ATOM   1787 C  CG   . TYR   A 1 255 ? -6.52236  -19.05795 -4.24089  1.000 28.43614  ? 260  TYR   A CG   1 
ATOM   1788 C  CD1  . TYR   A 1 255 ? -6.41247  -20.36993 -4.67697  1.000 28.40525  ? 260  TYR   A CD1  1 
ATOM   1789 C  CD2  . TYR   A 1 255 ? -5.84723  -18.06597 -4.93581  1.000 28.74744  ? 260  TYR   A CD2  1 
ATOM   1790 C  CE1  . TYR   A 1 255 ? -5.63146  -20.69694 -5.76196  1.000 32.58988  ? 260  TYR   A CE1  1 
ATOM   1791 C  CE2  . TYR   A 1 255 ? -5.04922  -18.37598 -6.02280  1.000 31.54536  ? 260  TYR   A CE2  1 
ATOM   1792 C  CZ   . TYR   A 1 255 ? -4.94933  -19.69396 -6.42888  1.000 32.11219  ? 260  TYR   A CZ   1 
ATOM   1793 O  OH   . TYR   A 1 255 ? -4.17933  -20.03697 -7.49987  1.000 38.13637  ? 260  TYR   A OH   1 
ATOM   1794 N  N    . CYS   A 1 256 ? -10.01953 -19.85076 -1.76808  1.000 25.39947  ? 261  CYS   A N    1 
ATOM   1795 C  CA   . CYS   A 1 256 ? -10.81258 -19.94576 -0.55511  1.000 23.04375  ? 261  CYS   A CA   1 
ATOM   1796 C  C    . CYS   A 1 256 ? -9.87161  -19.80093 0.62993   1.000 20.98312  ? 261  CYS   A C    1 
ATOM   1797 O  O    . CYS   A 1 256 ? -9.32573  -20.77101 1.14589   1.000 23.57698  ? 261  CYS   A O    1 
ATOM   1798 C  CB   . CYS   A 1 256 ? -11.61871 -21.23268 -0.55723  1.000 24.32214  ? 261  CYS   A CB   1 
ATOM   1799 S  SG   . CYS   A 1 256 ? -12.97464 -21.06147 -1.79827  1.000 23.47620  ? 261  CYS   A SG   1 
ATOM   1800 N  N    . ILE   A 1 257 ? -9.71351  -18.55597 1.06302   1.000 27.79222  ? 262  ILE   A N    1 
ATOM   1801 C  CA   . ILE   A 1 257 ? -8.77951  -18.16813 2.11208   1.000 23.55674  ? 262  ILE   A CA   1 
ATOM   1802 C  C    . ILE   A 1 257 ? -9.48657  -18.23014 3.46004   1.000 27.03919  ? 262  ILE   A C    1 
ATOM   1803 O  O    . ILE   A 1 257 ? -10.56852 -17.65105 3.63704   1.000 27.96765  ? 262  ILE   A O    1 
ATOM   1804 C  CB   . ILE   A 1 257 ? -8.23936  -16.76116 1.84518   1.000 20.98220  ? 262  ILE   A CB   1 
ATOM   1805 C  CG1  . ILE   A 1 257 ? -7.63830  -16.69313 0.44021   1.000 24.73964  ? 262  ILE   A CG1  1 
ATOM   1806 C  CG2  . ILE   A 1 257 ? -7.18037  -16.37733 2.87925   1.000 24.65482  ? 262  ILE   A CG2  1 
ATOM   1807 C  CD1  . ILE   A 1 257 ? -6.87017  -15.39119 0.18132   1.000 23.19146  ? 262  ILE   A CD1  1 
ATOM   1808 N  N    . PHE   A 1 258 ? -8.86567  -18.92126 4.41002   1.000 23.24601  ? 263  PHE   A N    1 
ATOM   1809 C  CA   . PHE   A 1 258 ? -9.37974  -19.07730 5.76500   1.000 23.99517  ? 263  PHE   A CA   1 
ATOM   1810 C  C    . PHE   A 1 258 ? -9.09865  -17.82038 6.58209   1.000 31.54588  ? 263  PHE   A C    1 
ATOM   1811 O  O    . PHE   A 1 258 ? -7.99559  -17.27048 6.53616   1.000 37.82826  ? 263  PHE   A O    1 
ATOM   1812 C  CB   . PHE   A 1 258 ? -8.70588  -20.29640 6.40794   1.000 29.09840  ? 263  PHE   A CB   1 
ATOM   1813 C  CG   . PHE   A 1 258 ? -9.49799  -20.96239 7.48287   1.000 24.06172  ? 263  PHE   A CG   1 
ATOM   1814 C  CD1  . PHE   A 1 258 ? -9.46799  -20.48948 8.78890   1.000 24.20162  ? 263  PHE   A CD1  1 
ATOM   1815 C  CD2  . PHE   A 1 258 ? -10.21509 -22.11231 7.20677   1.000 25.45578  ? 263  PHE   A CD2  1 
ATOM   1816 C  CE1  . PHE   A 1 258 ? -10.18009 -21.12647 9.80284   1.000 27.89343  ? 263  PHE   A CE1  1 
ATOM   1817 C  CE2  . PHE   A 1 258 ? -10.92519 -22.76530 8.21670   1.000 29.44694  ? 263  PHE   A CE2  1 
ATOM   1818 C  CZ   . PHE   A 1 258 ? -10.91819 -22.25938 9.51674   1.000 27.04074  ? 263  PHE   A CZ   1 
ATOM   1819 N  N    . ALA   A 1 259 ? -10.08763 -17.36933 7.34508   1.000 30.28612  ? 264  ALA   A N    1 
ATOM   1820 C  CA   . ALA   A 1 259 ? -9.93855  -16.18839 8.18916   1.000 27.91306  ? 264  ALA   A CA   1 
ATOM   1821 C  C    . ALA   A 1 259 ? -10.22564 -16.56946 9.63812   1.000 29.57193  ? 264  ALA   A C    1 
ATOM   1822 O  O    . ALA   A 1 259 ? -10.67876 -17.68143 9.93503   1.000 27.03284  ? 264  ALA   A O    1 
ATOM   1823 C  CB   . ALA   A 1 259 ? -10.86842 -15.05128 7.72719   1.000 24.01912  ? 264  ALA   A CB   1 
ATOM   1824 N  N    . ASN   A 1 260 ? -9.96259  -15.63754 10.55519  1.000 29.07385  ? 265  ASN   A N    1 
ATOM   1825 C  CA   . ASN   A 1 260 ? -10.08867 -15.95162 11.97416  1.000 28.58794  ? 265  ASN   A CA   1 
ATOM   1826 C  C    . ASN   A 1 260 ? -10.43358 -14.71664 12.77623  1.000 29.71599  ? 265  ASN   A C    1 
ATOM   1827 O  O    . ASN   A 1 260 ? -10.11846 -13.59264 12.38731  1.000 30.25260  ? 265  ASN   A O    1 
ATOM   1828 C  CB   . ASN   A 1 260 ? -8.79175  -16.51878 12.55018  1.000 30.52151  ? 265  ASN   A CB   1 
ATOM   1829 C  CG   . ASN   A 1 260 ? -8.34484  -17.74978 11.83912  1.000 33.82091  ? 265  ASN   A CG   1 
ATOM   1830 O  OD1  . ASN   A 1 260 ? -7.50780  -17.68580 10.94415  1.000 34.83646  ? 265  ASN   A OD1  1 
ATOM   1831 N  ND2  . ASN   A 1 260 ? -8.92096  -18.88475 12.21102  1.000 34.15816  ? 265  ASN   A ND2  1 
ATOM   1832 N  N    . PHE   A 1 261 ? -11.03865 -14.96265 13.93719  1.000 30.96765  ? 266  PHE   A N    1 
ATOM   1833 C  CA   . PHE   A 1 261 ? -11.08460 -14.00671 15.03625  1.000 30.34276  ? 266  PHE   A CA   1 
ATOM   1834 C  C    . PHE   A 1 261 ? -9.84365  -14.21089 15.89828  1.000 34.50330  ? 266  PHE   A C    1 
ATOM   1835 O  O    . PHE   A 1 261 ? -9.55578  -15.33494 16.32722  1.000 32.77225  ? 266  PHE   A O    1 
ATOM   1836 C  CB   . PHE   A 1 261 ? -12.33665 -14.20865 15.90119  1.000 29.17396  ? 266  PHE   A CB   1 
ATOM   1837 C  CG   . PHE   A 1 261 ? -13.63761 -14.05747 15.15915  1.000 38.61543  ? 266  PHE   A CG   1 
ATOM   1838 C  CD1  . PHE   A 1 261 ? -14.19969 -15.13438 14.47606  1.000 30.15277  ? 266  PHE   A CD1  1 
ATOM   1839 C  CD2  . PHE   A 1 261 ? -14.31749 -12.83841 15.16820  1.000 38.53811  ? 266  PHE   A CD2  1 
ATOM   1840 C  CE1  . PHE   A 1 261 ? -15.39865 -14.99222 13.80102  1.000 30.45051  ? 266  PHE   A CE1  1 
ATOM   1841 C  CE2  . PHE   A 1 261 ? -15.51445 -12.69025 14.47916  1.000 34.56675  ? 266  PHE   A CE2  1 
ATOM   1842 C  CZ   . PHE   A 1 261 ? -16.05453 -13.77115 13.80008  1.000 32.36803  ? 266  PHE   A CZ   1 
ATOM   1843 N  N    . SER   A 1 262 ? -9.10556  -13.14298 16.14338  1.000 30.31435  ? 267  SER   A N    1 
ATOM   1844 C  CA   . SER   A 1 262 ? -8.01560  -13.19014 17.10042  1.000 31.52130  ? 267  SER   A CA   1 
ATOM   1845 C  C    . SER   A 1 262 ? -8.52159  -12.57317 18.39944  1.000 34.92293  ? 267  SER   A C    1 
ATOM   1846 O  O    . SER   A 1 262 ? -8.96347  -11.41913 18.41249  1.000 35.67165  ? 267  SER   A O    1 
ATOM   1847 C  CB   . SER   A 1 262 ? -6.79750  -12.44523 16.57451  1.000 30.59846  ? 267  SER   A CB   1 
ATOM   1848 O  OG   . SER   A 1 262 ? -5.79254  -12.45139 17.55555  1.000 34.67959  ? 267  SER   A OG   1 
ATOM   1849 N  N    . VAL   A 1 263 ? -8.50870  -13.36024 19.47439  1.000 33.68861  ? 268  VAL   A N    1 
ATOM   1850 C  CA   . VAL   A 1 263 ? -9.10271  -12.94527 20.73739  1.000 37.81584  ? 268  VAL   A CA   1 
ATOM   1851 C  C    . VAL   A 1 263 ? -8.14376  -13.04143 21.91842  1.000 38.58961  ? 268  VAL   A C    1 
ATOM   1852 O  O    . VAL   A 1 263 ? -8.52377  -12.67447 23.03643  1.000 43.28540  ? 268  VAL   A O    1 
ATOM   1853 C  CB   . VAL   A 1 263 ? -10.37680 -13.75716 21.03229  1.000 37.66774  ? 268  VAL   A CB   1 
ATOM   1854 C  CG1  . VAL   A 1 263 ? -11.39874 -13.56699 19.90627  1.000 38.82303  ? 268  VAL   A CG1  1 
ATOM   1855 C  CG2  . VAL   A 1 263 ? -10.02795 -15.21820 21.20421  1.000 32.58921  ? 268  VAL   A CG2  1 
ATOM   1856 N  N    . THR   A 1 264 ? -6.91481  -13.53654 21.72844  1.000 35.89874  ? 269  THR   A N    1 
ATOM   1857 C  CA   . THR   A 1 264 ? -6.04287  -13.71370 22.88846  1.000 36.39845  ? 269  THR   A CA   1 
ATOM   1858 C  C    . THR   A 1 264 ? -5.56976  -12.37878 23.44656  1.000 35.55633  ? 269  THR   A C    1 
ATOM   1859 O  O    . THR   A 1 264 ? -5.30479  -12.27788 24.64958  1.000 39.01094  ? 269  THR   A O    1 
ATOM   1860 C  CB   . THR   A 1 264 ? -4.83594  -14.59479 22.54645  1.000 33.45570  ? 269  THR   A CB   1 
ATOM   1861 O  OG1  . THR   A 1 264 ? -4.18085  -14.07478 21.38251  1.000 34.19287  ? 269  THR   A OG1  1 
ATOM   1862 C  CG2  . THR   A 1 264 ? -5.27007  -16.02574 22.31434  1.000 30.93541  ? 269  THR   A CG2  1 
ATOM   1863 N  N    . GLY   A 1 265 ? -5.44063  -11.36174 22.59463  1.000 33.94579  ? 270  GLY   A N    1 
ATOM   1864 C  CA   . GLY   A 1 265 ? -5.01351  -10.04081 23.01373  1.000 36.08153  ? 270  GLY   A CA   1 
ATOM   1865 C  C    . GLY   A 1 265 ? -6.02040  -9.00168  22.57576  1.000 34.10465  ? 270  GLY   A C    1 
ATOM   1866 O  O    . GLY   A 1 265 ? -7.17342  -9.02660  23.01771  1.000 38.73579  ? 270  GLY   A O    1 
ATOM   1867 N  N    . GLY   A 1 266 ? -5.61328  -8.08767  21.70483  1.000 37.11454  ? 271  GLY   A N    1 
ATOM   1868 C  CA   . GLY   A 1 266 ? -6.57817  -7.25553  21.01285  1.000 38.30913  ? 271  GLY   A CA   1 
ATOM   1869 C  C    . GLY   A 1 266 ? -7.58722  -8.08638  20.23975  1.000 41.03323  ? 271  GLY   A C    1 
ATOM   1870 O  O    . GLY   A 1 266 ? -7.38832  -9.27138  19.96969  1.000 34.53322  ? 271  GLY   A O    1 
ATOM   1871 N  N    . LYS   A 1 267 ? -8.71415  -7.46025  19.89775  1.000 34.91006  ? 272  LYS   A N    1 
ATOM   1872 C  CA   . LYS   A 1 267 ? -9.77518  -8.14910  19.16467  1.000 37.88456  ? 272  LYS   A CA   1 
ATOM   1873 C  C    . LYS   A 1 267 ? -9.56310  -7.82903  17.69170  1.000 34.15651  ? 272  LYS   A C    1 
ATOM   1874 O  O    . LYS   A 1 267 ? -9.86097  -6.72097  17.23375  1.000 35.99500  ? 272  LYS   A O    1 
ATOM   1875 C  CB   . LYS   A 1 267 ? -11.15416 -7.74300  19.66964  1.000 38.51745  ? 272  LYS   A CB   1 
ATOM   1876 C  CG   . LYS   A 1 267 ? -11.37525 -8.05907  21.14161  1.000 38.13865  ? 272  LYS   A CG   1 
ATOM   1877 C  CD   . LYS   A 1 267 ? -11.18941 -9.54911  21.45653  1.000 37.20164  ? 272  LYS   A CD   1 
ATOM   1878 C  CE   . LYS   A 1 267 ? -11.23549 -9.78920  22.96351  1.000 46.14789  ? 272  LYS   A CE   1 
ATOM   1879 N  NZ   . LYS   A 1 267 ? -11.57664 -11.20119 23.31641  1.000 52.85925  ? 272  LYS   A NZ   1 
ATOM   1880 N  N    . TRP   A 1 268 ? -8.99416  -8.78704  16.96066  1.000 32.81867  ? 273  TRP   A N    1 
ATOM   1881 C  CA   . TRP   A 1 268 ? -8.64309  -8.58998  15.56468  1.000 31.00101  ? 273  TRP   A CA   1 
ATOM   1882 C  C    . TRP   A 1 268 ? -9.41115  -9.56185  14.68359  1.000 33.00468  ? 273  TRP   A C    1 
ATOM   1883 O  O    . TRP   A 1 268 ? -9.95927  -10.57183 15.14651  1.000 31.45684  ? 273  TRP   A O    1 
ATOM   1884 C  CB   . TRP   A 1 268 ? -7.14910  -8.80611  15.28773  1.000 30.94233  ? 273  TRP   A CB   1 
ATOM   1885 C  CG   . TRP   A 1 268 ? -6.21109  -8.30127  16.34879  1.000 38.08489  ? 273  TRP   A CG   1 
ATOM   1886 C  CD1  . TRP   A 1 268 ? -5.33819  -9.04240  17.08478  1.000 31.84180  ? 273  TRP   A CD1  1 
ATOM   1887 C  CD2  . TRP   A 1 268 ? -6.04198  -6.94031  16.77089  1.000 35.70413  ? 273  TRP   A CD2  1 
ATOM   1888 N  NE1  . TRP   A 1 268 ? -4.63915  -8.23152  17.94286  1.000 36.29697  ? 273  TRP   A NE1  1 
ATOM   1889 C  CE2  . TRP   A 1 268 ? -5.05501  -6.93847  17.77892  1.000 34.29708  ? 273  TRP   A CE2  1 
ATOM   1890 C  CE3  . TRP   A 1 268 ? -6.63584  -5.73123  16.40394  1.000 34.52012  ? 273  TRP   A CE3  1 
ATOM   1891 C  CZ2  . TRP   A 1 268 ? -4.64093  -5.77255  18.42001  1.000 35.10557  ? 273  TRP   A CZ2  1 
ATOM   1892 C  CZ3  . TRP   A 1 268 ? -6.22476  -4.57131  17.03503  1.000 37.74370  ? 273  TRP   A CZ3  1 
ATOM   1893 C  CH2  . TRP   A 1 268 ? -5.23580  -4.60147  18.04106  1.000 41.07029  ? 273  TRP   A CH2  1 
ATOM   1894 N  N    . ILE   A 1 269 ? -9.44107  -9.21777  13.40161  1.000 33.65873  ? 274  ILE   A N    1 
ATOM   1895 C  CA   . ILE   A 1 269 ? -9.79412  -10.12767 12.32754  1.000 32.36961  ? 274  ILE   A CA   1 
ATOM   1896 C  C    . ILE   A 1 269 ? -8.51411  -10.38674 11.55157  1.000 29.28228  ? 274  ILE   A C    1 
ATOM   1897 O  O    . ILE   A 1 269 ? -7.73501  -9.46380  11.30066  1.000 28.24871  ? 274  ILE   A O    1 
ATOM   1898 C  CB   . ILE   A 1 269 ? -10.91003 -9.54750  11.43154  1.000 29.77134  ? 274  ILE   A CB   1 
ATOM   1899 C  CG1  . ILE   A 1 269 ? -12.19404 -9.32843  12.24250  1.000 29.54990  ? 274  ILE   A CG1  1 
ATOM   1900 C  CG2  . ILE   A 1 269 ? -11.17107 -10.45240 10.24347  1.000 28.13814  ? 274  ILE   A CG2  1 
ATOM   1901 C  CD1  . ILE   A 1 269 ? -12.89318 -10.59639 12.70540  1.000 29.77972  ? 274  ILE   A CD1  1 
ATOM   1902 N  N    . VAL   A 1 270 ? -8.26822  -11.64775 11.22450  1.000 31.27936  ? 275  VAL   A N    1 
ATOM   1903 C  CA   . VAL   A 1 270 ? -7.03224  -12.06783 10.57253  1.000 26.99525  ? 275  VAL   A CA   1 
ATOM   1904 C  C    . VAL   A 1 270 ? -7.38427  -12.84471 9.31646   1.000 28.21030  ? 275  VAL   A C    1 
ATOM   1905 O  O    . VAL   A 1 270 ? -8.21236  -13.75864 9.36237   1.000 29.29197  ? 275  VAL   A O    1 
ATOM   1906 C  CB   . VAL   A 1 270 ? -6.17136  -12.95297 11.49850  1.000 27.49251  ? 275  VAL   A CB   1 
ATOM   1907 C  CG1  . VAL   A 1 270 ? -4.92238  -13.44604 10.76152  1.000 24.78420  ? 275  VAL   A CG1  1 
ATOM   1908 C  CG2  . VAL   A 1 270 ? -5.82834  -12.22608 12.80356  1.000 23.77352  ? 275  VAL   A CG2  1 
ATOM   1909 N  N    . SER   A 1 271 ? -6.72319  -12.53071 8.20751   1.000 23.45110  ? 276  SER   A N    1 
ATOM   1910 C  CA   . SER   A 1 271 ? -6.92723  -13.34561 7.02445   1.000 28.75012  ? 276  SER   A CA   1 
ATOM   1911 C  C    . SER   A 1 271 ? -5.69119  -13.28468 6.14950   1.000 26.10499  ? 276  SER   A C    1 
ATOM   1912 O  O    . SER   A 1 271 ? -4.93810  -12.31076 6.19059   1.000 30.56264  ? 276  SER   A O    1 
ATOM   1913 C  CB   . SER   A 1 271 ? -8.17015  -12.88244 6.23943   1.000 25.55701  ? 276  SER   A CB   1 
ATOM   1914 O  OG   . SER   A 1 271 ? -8.25817  -13.51536 4.97639   1.000 25.42436  ? 276  SER   A OG   1 
ATOM   1915 N  N    . GLY   A 1 272 ? -5.49026  -14.34565 5.36944   1.000 27.76180  ? 277  GLY   A N    1 
ATOM   1916 C  CA   . GLY   A 1 272 ? -4.56122  -14.31867 4.26148   1.000 24.87822  ? 277  GLY   A CA   1 
ATOM   1917 C  C    . GLY   A 1 272 ? -5.11609  -13.45655 3.13551   1.000 27.31744  ? 277  GLY   A C    1 
ATOM   1918 O  O    . GLY   A 1 272 ? -6.18804  -12.86045 3.22151   1.000 27.33162  ? 277  GLY   A O    1 
ATOM   1919 N  N    . SER   A 1 273 ? -4.36305  -13.41255 2.04854   1.000 24.49440  ? 278  SER   A N    1 
ATOM   1920 C  CA   . SER   A 1 273 ? -4.58091  -12.45446 0.98559   1.000 25.82969  ? 278  SER   A CA   1 
ATOM   1921 C  C    . SER   A 1 273 ? -3.81191  -12.92446 -0.23941  1.000 26.36901  ? 278  SER   A C    1 
ATOM   1922 O  O    . SER   A 1 273 ? -2.73797  -13.51757 -0.11840  1.000 26.80777  ? 278  SER   A O    1 
ATOM   1923 C  CB   . SER   A 1 273 ? -4.11379  -11.05353 1.38270   1.000 25.75253  ? 278  SER   A CB   1 
ATOM   1924 O  OG   . SER   A 1 273 ? -4.33866  -10.16844 0.30975   1.000 29.58735  ? 278  SER   A OG   1 
ATOM   1925 N  N    . GLU   A 1 274 ? -4.36384  -12.64633 -1.41341  1.000 25.49150  ? 279  GLU   A N    1 
ATOM   1926 C  CA   . GLU   A 1 274 ? -3.74584  -13.10932 -2.64942  1.000 25.36688  ? 279  GLU   A CA   1 
ATOM   1927 C  C    . GLU   A 1 274 ? -2.57974  -12.23140 -3.09032  1.000 26.15848  ? 279  GLU   A C    1 
ATOM   1928 O  O    . GLU   A 1 274 ? -1.94473  -12.54640 -4.10531  1.000 26.87035  ? 279  GLU   A O    1 
ATOM   1929 C  CB   . GLU   A 1 274 ? -4.79881  -13.21514 -3.74746  1.000 26.26461  ? 279  GLU   A CB   1 
ATOM   1930 C  CG   . GLU   A 1 274 ? -5.78493  -14.38206 -3.50857  1.000 29.20379  ? 279  GLU   A CG   1 
ATOM   1931 C  CD   . GLU   A 1 274 ? -7.11589  -14.25189 -4.26962  1.000 28.46907  ? 279  GLU   A CD   1 
ATOM   1932 O  OE1  . GLU   A 1 274 ? -7.32276  -13.24182 -4.98356  1.000 30.09207  ? 279  GLU   A OE1  1 
ATOM   1933 O  OE2  . GLU   A 1 274 ? -7.96898  -15.16481 -4.13971  1.000 27.79454  ? 279  GLU   A OE2  1 
ATOM   1934 N  N    . ASP   A 1 275 ? -2.28766  -11.14547 -2.36624  1.000 25.99062  ? 280  ASP   A N    1 
ATOM   1935 C  CA   . ASP   A 1 275 ? -1.03358  -10.42059 -2.53214  1.000 31.83304  ? 280  ASP   A CA   1 
ATOM   1936 C  C    . ASP   A 1 275 ? 0.04633   -10.91475 -1.58113  1.000 29.02830  ? 280  ASP   A C    1 
ATOM   1937 O  O    . ASP   A 1 275 ? 1.02540   -10.19786 -1.36305  1.000 29.64473  ? 280  ASP   A O    1 
ATOM   1938 C  CB   . ASP   A 1 275 ? -1.23444  -8.90458  -2.35906  1.000 23.99025  ? 280  ASP   A CB   1 
ATOM   1939 C  CG   . ASP   A 1 275 ? -1.73046  -8.52462  -0.98005  1.000 29.50556  ? 280  ASP   A CG   1 
ATOM   1940 O  OD1  . ASP   A 1 275 ? -1.83758  -9.40066  -0.09111  1.000 33.55867  ? 280  ASP   A OD1  1 
ATOM   1941 O  OD2  . ASP   A 1 275 ? -2.04835  -7.33860  -0.78099  1.000 33.16905  ? 280  ASP   A OD2  1 
ATOM   1942 N  N    . ASN   A 1 276 ? -0.11980  -12.11277 -1.00422  1.000 28.47650  ? 281  ASN   A N    1 
ATOM   1943 C  CA   . ASN   A 1 276 ? 0.90810   -12.82192 -0.23722  1.000 30.65622  ? 281  ASN   A CA   1 
ATOM   1944 C  C    . ASN   A 1 276 ? 1.13110   -12.24903 1.15582   1.000 31.31872  ? 281  ASN   A C    1 
ATOM   1945 O  O    . ASN   A 1 276 ? 2.12704   -12.58517 1.80084   1.000 32.60527  ? 281  ASN   A O    1 
ATOM   1946 C  CB   . ASN   A 1 276 ? 2.25112   -12.86600 -0.97817  1.000 28.58876  ? 281  ASN   A CB   1 
ATOM   1947 C  CG   . ASN   A 1 276 ? 2.12113   -13.37790 -2.39821  1.000 34.35537  ? 281  ASN   A CG   1 
ATOM   1948 O  OD1  . ASN   A 1 276 ? 1.10708   -13.98778 -2.78029  1.000 33.38463  ? 281  ASN   A OD1  1 
ATOM   1949 N  ND2  . ASN   A 1 276 ? 3.15518   -13.13795 -3.19716  1.000 31.47709  ? 281  ASN   A ND2  1 
ATOM   1950 N  N    . LEU   A 1 277 ? 0.21916   -11.41897 1.65984   1.000 28.99194  ? 282  LEU   A N    1 
ATOM   1951 C  CA   . LEU   A 1 277 ? 0.32317   -10.82906 2.98088   1.000 29.01746  ? 282  LEU   A CA   1 
ATOM   1952 C  C    . LEU   A 1 277 ? -0.71193  -11.43802 3.91280   1.000 32.21515  ? 282  LEU   A C    1 
ATOM   1953 O  O    . LEU   A 1 277 ? -1.77395  -11.87789 3.47274   1.000 27.08386  ? 282  LEU   A O    1 
ATOM   1954 C  CB   . LEU   A 1 277 ? 0.09132   -9.32004  2.92697   1.000 29.32845  ? 282  LEU   A CB   1 
ATOM   1955 C  CG   . LEU   A 1 277 ? 0.89643   -8.58505  1.86505   1.000 29.09231  ? 282  LEU   A CG   1 
ATOM   1956 C  CD1  . LEU   A 1 277 ? 0.49557   -7.10901  1.83812   1.000 28.20593  ? 282  LEU   A CD1  1 
ATOM   1957 C  CD2  . LEU   A 1 277 ? 2.38040   -8.75421  2.17309   1.000 30.86622  ? 282  LEU   A CD2  1 
ATOM   1958 N  N    . VAL   A 1 278 ? -0.39698  -11.45713 5.20882   1.000 25.81921  ? 283  VAL   A N    1 
ATOM   1959 C  CA   . VAL   A 1 278 ? -1.41303  -11.61710 6.23177   1.000 28.18651  ? 283  VAL   A CA   1 
ATOM   1960 C  C    . VAL   A 1 278 ? -1.95891  -10.23907 6.56683   1.000 32.81070  ? 283  VAL   A C    1 
ATOM   1961 O  O    . VAL   A 1 278 ? -1.19283  -9.31316  6.83692   1.000 30.89552  ? 283  VAL   A O    1 
ATOM   1962 C  CB   . VAL   A 1 278 ? -0.84414  -12.28823 7.48575   1.000 28.07108  ? 283  VAL   A CB   1 
ATOM   1963 C  CG1  . VAL   A 1 278 ? -1.94820  -12.46119 8.50869   1.000 24.49117  ? 283  VAL   A CG1  1 
ATOM   1964 C  CG2  . VAL   A 1 278 ? -0.19826  -13.61127 7.12769   1.000 30.25846  ? 283  VAL   A CG2  1 
ATOM   1965 N  N    . TYR   A 1 279 ? -3.27690  -10.10294 6.56079   1.000 30.95720  ? 284  TYR   A N    1 
ATOM   1966 C  CA   . TYR   A 1 279 ? -3.93579  -8.86490  6.93784   1.000 29.20189  ? 284  TYR   A CA   1 
ATOM   1967 C  C    . TYR   A 1 279 ? -4.51386  -9.01993  8.33381   1.000 29.34500  ? 284  TYR   A C    1 
ATOM   1968 O  O    . TYR   A 1 279 ? -5.01798  -10.08691 8.70673   1.000 30.32229  ? 284  TYR   A O    1 
ATOM   1969 C  CB   . TYR   A 1 279 ? -5.04672  -8.48473  5.94383   1.000 28.75667  ? 284  TYR   A CB   1 
ATOM   1970 C  CG   . TYR   A 1 279 ? -4.53460  -7.82670  4.67089   1.000 26.01646  ? 284  TYR   A CG   1 
ATOM   1971 C  CD1  . TYR   A 1 279 ? -3.83964  -8.55771  3.71987   1.000 27.50372  ? 284  TYR   A CD1  1 
ATOM   1972 C  CD2  . TYR   A 1 279 ? -4.74346  -6.45966  4.42896   1.000 28.80505  ? 284  TYR   A CD2  1 
ATOM   1973 C  CE1  . TYR   A 1 279 ? -3.36053  -7.95168  2.55192   1.000 26.85202  ? 284  TYR   A CE1  1 
ATOM   1974 C  CE2  . TYR   A 1 279 ? -4.25536  -5.83864  3.26902   1.000 26.72148  ? 284  TYR   A CE2  1 
ATOM   1975 C  CZ   . TYR   A 1 279 ? -3.56339  -6.58865  2.34000   1.000 27.32269  ? 284  TYR   A CZ   1 
ATOM   1976 O  OH   . TYR   A 1 279 ? -3.07829  -5.99062  1.18406   1.000 29.41364  ? 284  TYR   A OH   1 
ATOM   1977 N  N    . ILE   A 1 280 ? -4.41978  -7.96199  9.11688   1.000 29.01180  ? 285  ILE   A N    1 
ATOM   1978 C  CA   . ILE   A 1 280 ? -5.03083  -7.93301  10.43686  1.000 31.08503  ? 285  ILE   A CA   1 
ATOM   1979 C  C    . ILE   A 1 280 ? -5.82071  -6.64094  10.53991  1.000 31.32053  ? 285  ILE   A C    1 
ATOM   1980 O  O    . ILE   A 1 280 ? -5.28560  -5.56598  10.25400  1.000 29.12850  ? 285  ILE   A O    1 
ATOM   1981 C  CB   . ILE   A 1 280 ? -3.98188  -8.02319  11.55990  1.000 25.73128  ? 285  ILE   A CB   1 
ATOM   1982 C  CG1  . ILE   A 1 280 ? -3.05399  -9.21126  11.29086  1.000 27.91633  ? 285  ILE   A CG1  1 
ATOM   1983 C  CG2  . ILE   A 1 280 ? -4.67195  -8.16620  12.92486  1.000 26.12210  ? 285  ILE   A CG2  1 
ATOM   1984 C  CD1  . ILE   A 1 280 ? -2.05805  -9.45443  12.40388  1.000 28.36689  ? 285  ILE   A CD1  1 
ATOM   1985 N  N    . TRP   A 1 281 ? -7.09074  -6.75184  10.92986  1.000 31.04107  ? 286  TRP   A N    1 
ATOM   1986 C  CA   . TRP   A 1 281 ? -7.98463  -5.61677  11.07089  1.000 33.29679  ? 286  TRP   A CA   1 
ATOM   1987 C  C    . TRP   A 1 281 ? -8.40867  -5.48382  12.52189  1.000 31.72923  ? 286  TRP   A C    1 
ATOM   1988 O  O    . TRP   A 1 281 ? -8.51180  -6.47685  13.25782  1.000 31.96097  ? 286  TRP   A O    1 
ATOM   1989 C  CB   . TRP   A 1 281 ? -9.27261  -5.75259  10.23384  1.000 31.87144  ? 286  TRP   A CB   1 
ATOM   1990 C  CG   . TRP   A 1 281 ? -9.14556  -5.75251  8.74684   1.000 30.75738  ? 286  TRP   A CG   1 
ATOM   1991 C  CD1  . TRP   A 1 281 ? -9.31442  -4.67844  7.90390   1.000 31.79193  ? 286  TRP   A CD1  1 
ATOM   1992 C  CD2  . TRP   A 1 281 ? -8.86763  -6.88848  7.90178   1.000 31.03598  ? 286  TRP   A CD2  1 
ATOM   1993 N  NE1  . TRP   A 1 281 ? -9.15041  -5.07837  6.58788   1.000 34.37583  ? 286  TRP   A NE1  1 
ATOM   1994 C  CE2  . TRP   A 1 281 ? -8.87754  -6.42740  6.56181   1.000 34.10056  ? 286  TRP   A CE2  1 
ATOM   1995 C  CE3  . TRP   A 1 281 ? -8.61678  -8.25052  8.14971   1.000 32.62468  ? 286  TRP   A CE3  1 
ATOM   1996 C  CZ2  . TRP   A 1 281 ? -8.64158  -7.27535  5.47677   1.000 29.91346  ? 286  TRP   A CZ2  1 
ATOM   1997 C  CZ3  . TRP   A 1 281 ? -8.38682  -9.09148  7.07866   1.000 28.70330  ? 286  TRP   A CZ3  1 
ATOM   1998 C  CH2  . TRP   A 1 281 ? -8.40372  -8.60039  5.74569   1.000 28.90628  ? 286  TRP   A CH2  1 
ATOM   1999 N  N    . ASN   A 1 282 ? -8.67957  -4.24281  12.90695  1.000 36.04838  ? 287  ASN   A N    1 
ATOM   2000 C  CA   . ASN   A 1 282 ? -9.41059  -3.96982  14.13694  1.000 34.75439  ? 287  ASN   A CA   1 
ATOM   2001 C  C    . ASN   A 1 282 ? -10.86063 -4.42867  13.97586  1.000 34.26824  ? 287  ASN   A C    1 
ATOM   2002 O  O    . ASN   A 1 282 ? -11.57155 -3.94554  13.08886  1.000 38.13611  ? 287  ASN   A O    1 
ATOM   2003 C  CB   . ASN   A 1 282 ? -9.32545  -2.47385  14.43804  1.000 38.19096  ? 287  ASN   A CB   1 
ATOM   2004 C  CG   . ASN   A 1 282 ? -9.98047  -2.10287  15.73204  1.000 40.33491  ? 287  ASN   A CG   1 
ATOM   2005 O  OD1  . ASN   A 1 282 ? -11.06153 -2.59578  16.06697  1.000 40.44223  ? 287  ASN   A OD1  1 
ATOM   2006 N  ND2  . ASN   A 1 282 ? -9.32941  -1.22498  16.48412  1.000 41.24469  ? 287  ASN   A ND2  1 
ATOM   2007 N  N    . LEU   A 1 283 ? -11.31575 -5.36268  14.81878  1.000 33.41777  ? 288  LEU   A N    1 
ATOM   2008 C  CA   . LEU   A 1 283 ? -12.64879 -5.91953  14.59670  1.000 36.55660  ? 288  LEU   A CA   1 
ATOM   2009 C  C    . LEU   A 1 283 ? -13.71969 -4.83244  14.69873  1.000 41.55959  ? 288  LEU   A C    1 
ATOM   2010 O  O    . LEU   A 1 283 ? -14.64066 -4.77430  13.87369  1.000 36.69497  ? 288  LEU   A O    1 
ATOM   2011 C  CB   . LEU   A 1 283 ? -12.92594 -7.06457  15.57862  1.000 35.76471  ? 288  LEU   A CB   1 
ATOM   2012 C  CG   . LEU   A 1 283 ? -14.24401 -7.83743  15.42652  1.000 40.13057  ? 288  LEU   A CG   1 
ATOM   2013 C  CD1  . LEU   A 1 283 ? -14.15417 -9.23448  16.04343  1.000 37.71490  ? 288  LEU   A CD1  1 
ATOM   2014 C  CD2  . LEU   A 1 283 ? -15.42896 -7.08336  16.05252  1.000 41.39944  ? 288  LEU   A CD2  1 
ATOM   2015 N  N    . GLN   A 1 284 ? -13.60564 -3.95151  15.69379  1.000 40.52386  ? 289  GLN   A N    1 
ATOM   2016 C  CA   . GLN   A 1 284 ? -14.64356 -2.95242  15.90781  1.000 40.39653  ? 289  GLN   A CA   1 
ATOM   2017 C  C    . GLN   A 1 284 ? -14.58341 -1.83136  14.88288  1.000 41.17170  ? 289  GLN   A C    1 
ATOM   2018 O  O    . GLN   A 1 284 ? -15.62435 -1.41523  14.36587  1.000 41.26430  ? 289  GLN   A O    1 
ATOM   2019 C  CB   . GLN   A 1 284 ? -14.54055 -2.38352  17.31985  1.000 44.99793  ? 289  GLN   A CB   1 
ATOM   2020 C  CG   . GLN   A 1 284 ? -14.95869 -3.37555  18.39077  1.000 44.18423  ? 289  GLN   A CG   1 
ATOM   2021 C  CD   . GLN   A 1 284 ? -16.37873 -3.88740  18.19668  1.000 49.15021  ? 289  GLN   A CD   1 
ATOM   2022 O  OE1  . GLN   A 1 284 ? -16.73786 -4.96339  18.69160  1.000 55.09259  ? 289  GLN   A OE1  1 
ATOM   2023 N  NE2  . GLN   A 1 284 ? -17.19763 -3.11827  17.47670  1.000 53.03319  ? 289  GLN   A NE2  1 
ATOM   2024 N  N    . THR   A 1 285 ? -13.38935 -1.34546  14.55696  1.000 38.74805  ? 290  THR   A N    1 
ATOM   2025 C  CA   . THR   A 1 285 ? -13.25620 -0.18542  13.68904  1.000 38.11109  ? 290  THR   A CA   1 
ATOM   2026 C  C    . THR   A 1 285 ? -13.01818 -0.52935  12.22102  1.000 42.43289  ? 290  THR   A C    1 
ATOM   2027 O  O    . THR   A 1 285 ? -13.08506 0.37171   11.36608  1.000 36.38159  ? 290  THR   A O    1 
ATOM   2028 C  CB   . THR   A 1 285 ? -12.10814 0.69644   14.17014  1.000 41.86353  ? 290  THR   A CB   1 
ATOM   2029 O  OG1  . THR   A 1 285 ? -10.87816 0.22136   13.60215  1.000 42.47355  ? 290  THR   A OG1  1 
ATOM   2030 C  CG2  . THR   A 1 285 ? -12.03220 0.64634   15.68513  1.000 42.44500  ? 290  THR   A CG2  1 
ATOM   2031 N  N    . LYS   A 1 286 ? -12.70629 -1.78336  11.89896  1.000 40.44257  ? 291  LYS   A N    1 
ATOM   2032 C  CA   . LYS   A 1 286 ? -12.56328 -2.23329  10.51793  1.000 40.76450  ? 291  LYS   A CA   1 
ATOM   2033 C  C    . LYS   A 1 286 ? -11.31820 -1.68336  9.83602   1.000 35.90018  ? 291  LYS   A C    1 
ATOM   2034 O  O    . LYS   A 1 286 ? -11.11818 -1.94331  8.64401   1.000 39.55291  ? 291  LYS   A O    1 
ATOM   2035 C  CB   . LYS   A 1 286 ? -13.79021 -1.86211  9.66091   1.000 39.59255  ? 291  LYS   A CB   1 
ATOM   2036 C  CG   . LYS   A 1 286 ? -15.11028 -2.31302  10.27383  1.000 42.49243  ? 291  LYS   A CG   1 
ATOM   2037 C  CD   . LYS   A 1 286 ? -16.29920 -1.77686  9.49882   1.000 42.61485  ? 291  LYS   A CD   1 
ATOM   2038 C  CE   . LYS   A 1 286 ? -16.37405 -0.25386  9.56791   1.000 50.50054  ? 291  LYS   A CE   1 
ATOM   2039 N  NZ   . LYS   A 1 286 ? -17.68498 0.24731   9.02989   1.000 47.91278  ? 291  LYS   A NZ   1 
ATOM   2040 N  N    . GLU   A 1 287 ? -10.48315 -0.91649  10.52510  1.000 37.41907  ? 292  GLU   A N    1 
ATOM   2041 C  CA   . GLU   A 1 287 ? -9.26608  -0.44757  9.87717   1.000 37.47724  ? 292  GLU   A CA   1 
ATOM   2042 C  C    . GLU   A 1 287 ? -8.18219  -1.51868  9.94314   1.000 35.42887  ? 292  GLU   A C    1 
ATOM   2043 O  O    . GLU   A 1 287 ? -8.10530  -2.30774  10.88910  1.000 34.30508  ? 292  GLU   A O    1 
ATOM   2044 C  CB   . GLU   A 1 287 ? -8.77298  0.83834   10.52927  1.000 42.77898  ? 292  GLU   A CB   1 
ATOM   2045 C  CG   . GLU   A 1 287 ? -8.43006  0.64322   11.97827  1.000 48.41883  ? 292  GLU   A CG   1 
ATOM   2046 C  CD   . GLU   A 1 287 ? -8.61597  1.91219   12.80034  1.000 59.45927  ? 292  GLU   A CD   1 
ATOM   2047 O  OE1  . GLU   A 1 287 ? -8.93284  2.95926   12.18840  1.000 66.69928  ? 292  GLU   A OE1  1 
ATOM   2048 O  OE2  . GLU   A 1 287 ? -8.44502  1.85209   14.04935  1.000 55.54868  ? 292  GLU   A OE2  1 
ATOM   2049 N  N    . ILE   A 1 288 ? -7.34815  -1.54369  8.91317   1.000 32.69012  ? 293  ILE   A N    1 
ATOM   2050 C  CA   . ILE   A 1 288 ? -6.21724  -2.45680  8.86116   1.000 37.94128  ? 293  ILE   A CA   1 
ATOM   2051 C  C    . ILE   A 1 288 ? -5.20224  -2.03796  9.91823   1.000 38.91225  ? 293  ILE   A C    1 
ATOM   2052 O  O    . ILE   A 1 288 ? -4.69313  -0.91101  9.89432   1.000 38.52947  ? 293  ILE   A O    1 
ATOM   2053 C  CB   . ILE   A 1 288 ? -5.58919  -2.44977  7.46018   1.000 33.83247  ? 293  ILE   A CB   1 
ATOM   2054 C  CG1  . ILE   A 1 288 ? -6.59220  -2.96361  6.41011   1.000 29.26028  ? 293  ILE   A CG1  1 
ATOM   2055 C  CG2  . ILE   A 1 288 ? -4.28026  -3.24690  7.45718   1.000 30.47769  ? 293  ILE   A CG2  1 
ATOM   2056 C  CD1  . ILE   A 1 288 ? -6.05413  -2.87757  4.98314   1.000 29.76461  ? 293  ILE   A CD1  1 
ATOM   2057 N  N    . VAL   A 1 289 ? -4.87436  -2.94505  10.84118  1.000 35.59310  ? 294  VAL   A N    1 
ATOM   2058 C  CA   . VAL   A 1 289 ? -3.90137  -2.60321  11.87324  1.000 35.06640  ? 294  VAL   A CA   1 
ATOM   2059 C  C    . VAL   A 1 289 ? -2.51342  -3.20933  11.63925  1.000 35.85125  ? 294  VAL   A C    1 
ATOM   2060 O  O    . VAL   A 1 289 ? -1.53439  -2.71647  12.22232  1.000 36.79992  ? 294  VAL   A O    1 
ATOM   2061 C  CB   . VAL   A 1 289 ? -4.42146  -2.98625  13.27520  1.000 36.54550  ? 294  VAL   A CB   1 
ATOM   2062 C  CG1  . VAL   A 1 289 ? -5.67839  -2.18015  13.61020  1.000 35.89198  ? 294  VAL   A CG1  1 
ATOM   2063 C  CG2  . VAL   A 1 289 ? -4.68061  -4.48723  13.36609  1.000 34.45292  ? 294  VAL   A CG2  1 
ATOM   2064 N  N    . GLN   A 1 290 ? -2.39249  -4.24429  10.80719  1.000 33.93408  ? 295  GLN   A N    1 
ATOM   2065 C  CA   . GLN   A 1 290 ? -1.07052  -4.74640  10.45921  1.000 33.09513  ? 295  GLN   A CA   1 
ATOM   2066 C  C    . GLN   A 1 290 ? -1.17156  -5.59531  9.20815   1.000 35.35405  ? 295  GLN   A C    1 
ATOM   2067 O  O    . GLN   A 1 290 ? -2.19161  -6.25420  8.95407   1.000 30.38719  ? 295  GLN   A O    1 
ATOM   2068 C  CB   . GLN   A 1 290 ? -0.44565  -5.56453  11.59818  1.000 33.75349  ? 295  GLN   A CB   1 
ATOM   2069 C  CG   . GLN   A 1 290 ? 1.05637   -5.33569  11.76426  1.000 36.92062  ? 295  GLN   A CG   1 
ATOM   2070 C  CD   . GLN   A 1 290 ? 1.72724   -6.30981  12.73722  1.000 37.06435  ? 295  GLN   A CD   1 
ATOM   2071 O  OE1  . GLN   A 1 290 ? 1.07815   -6.89481  13.61016  1.000 30.80756  ? 295  GLN   A OE1  1 
ATOM   2072 N  NE2  . GLN   A 1 290 ? 3.03723   -6.48693  12.57626  1.000 34.50210  ? 295  GLN   A NE2  1 
ATOM   2073 N  N    . LYS   A 1 291 ? -0.09553  -5.56737  8.42920   1.000 32.20804  ? 296  LYS   A N    1 
ATOM   2074 C  CA   . LYS   A 1 291 ? 0.07543   -6.43731  7.27515   1.000 32.53736  ? 296  LYS   A CA   1 
ATOM   2075 C  C    . LYS   A 1 291 ? 1.41836   -7.14145  7.39816   1.000 37.74436  ? 296  LYS   A C    1 
ATOM   2076 O  O    . LYS   A 1 291 ? 2.45542   -6.48056  7.50124   1.000 35.36250  ? 296  LYS   A O    1 
ATOM   2077 C  CB   . LYS   A 1 291 ? -0.01744  -5.62622  5.98620   1.000 37.86586  ? 296  LYS   A CB   1 
ATOM   2078 C  CG   . LYS   A 1 291 ? -1.45739  -5.19906  5.70117   1.000 35.49207  ? 296  LYS   A CG   1 
ATOM   2079 C  CD   . LYS   A 1 291 ? -1.53823  -3.91101  4.94425   1.000 41.12811  ? 296  LYS   A CD   1 
ATOM   2080 C  CE   . LYS   A 1 291 ? -0.84119  -3.97699  3.61427   1.000 38.15156  ? 296  LYS   A CE   1 
ATOM   2081 N  NZ   . LYS   A 1 291 ? -0.91903  -2.63394  2.96735   1.000 49.78185  ? 296  LYS   A NZ   1 
ATOM   2082 N  N    . LEU   A 1 292 ? 1.39823   -8.47745  7.40207   1.000 35.21502  ? 297  LEU   A N    1 
ATOM   2083 C  CA   . LEU   A 1 292 ? 2.57514   -9.29558  7.69006   1.000 33.71862  ? 297  LEU   A CA   1 
ATOM   2084 C  C    . LEU   A 1 292 ? 3.18314   -9.76956  6.37806   1.000 34.41398  ? 297  LEU   A C    1 
ATOM   2085 O  O    . LEU   A 1 292 ? 2.53910   -10.49645 5.60999   1.000 31.62802  ? 297  LEU   A O    1 
ATOM   2086 C  CB   . LEU   A 1 292 ? 2.22299   -10.49560 8.57198   1.000 26.57206  ? 297  LEU   A CB   1 
ATOM   2087 C  CG   . LEU   A 1 292 ? 1.44597   -10.20561 9.86096   1.000 31.07636  ? 297  LEU   A CG   1 
ATOM   2088 C  CD1  . LEU   A 1 292 ? 1.26481   -11.44764 10.73088  1.000 27.99179  ? 297  LEU   A CD1  1 
ATOM   2089 C  CD2  . LEU   A 1 292 ? 2.11105   -9.08172  10.67606  1.000 31.02667  ? 297  LEU   A CD2  1 
ATOM   2090 N  N    . GLN   A 1 293 ? 4.42719   -9.37866  6.13013   1.000 30.15241  ? 298  GLN   A N    1 
ATOM   2091 C  CA   . GLN   A 1 293 ? 5.08921   -9.67965  4.87214   1.000 32.91234  ? 298  GLN   A CA   1 
ATOM   2092 C  C    . GLN   A 1 293 ? 6.12710   -10.78776 5.03711   1.000 35.64452  ? 298  GLN   A C    1 
ATOM   2093 O  O    . GLN   A 1 293 ? 6.79405   -10.89289 6.07012   1.000 36.53683  ? 298  GLN   A O    1 
ATOM   2094 C  CB   . GLN   A 1 293 ? 5.75035   -8.43168  4.31824   1.000 37.65591  ? 298  GLN   A CB   1 
ATOM   2095 C  CG   . GLN   A 1 293 ? 6.56437   -8.69468  3.07225   1.000 47.81514  ? 298  GLN   A CG   1 
ATOM   2096 C  CD   . GLN   A 1 293 ? 7.55349   -7.58376  2.84336   1.000 54.08697  ? 298  GLN   A CD   1 
ATOM   2097 O  OE1  . GLN   A 1 293 ? 8.75347   -7.83187  2.69739   1.000 57.18530  ? 298  GLN   A OE1  1 
ATOM   2098 N  NE2  . GLN   A 1 293 ? 7.06361   -6.33871  2.85542   1.000 58.40529  ? 298  GLN   A NE2  1 
ATOM   2099 N  N    . GLY   A 1 294 ? 6.27506   -11.60571 3.99906   1.000 31.50964  ? 299  GLY   A N    1 
ATOM   2100 C  CA   . GLY   A 1 294 ? 7.23195   -12.69081 4.07903   1.000 34.56438  ? 299  GLY   A CA   1 
ATOM   2101 C  C    . GLY   A 1 294 ? 6.93587   -13.82072 3.12095   1.000 35.09333  ? 299  GLY   A C    1 
ATOM   2102 O  O    . GLY   A 1 294 ? 7.84484   -14.36476 2.48395   1.000 30.60246  ? 299  GLY   A O    1 
ATOM   2103 N  N    . HIS   A 1 295 ? 5.66384   -14.18158 2.99187   1.000 27.98333  ? 300  HIS   A N    1 
ATOM   2104 C  CA   . HIS   A 1 295 ? 5.33277   -15.27350 2.10179   1.000 26.27903  ? 300  HIS   A CA   1 
ATOM   2105 C  C    . HIS   A 1 295 ? 5.58687   -14.86943 0.65183   1.000 25.59149  ? 300  HIS   A C    1 
ATOM   2106 O  O    . HIS   A 1 295 ? 5.63799   -13.68541 0.29990   1.000 29.87064  ? 300  HIS   A O    1 
ATOM   2107 C  CB   . HIS   A 1 295 ? 3.87972   -15.70537 2.30871   1.000 27.95771  ? 300  HIS   A CB   1 
ATOM   2108 C  CG   . HIS   A 1 295 ? 3.67659   -16.54243 3.53165   1.000 25.66607  ? 300  HIS   A CG   1 
ATOM   2109 N  ND1  . HIS   A 1 295 ? 4.16646   -17.82648 3.64159   1.000 27.60481  ? 300  HIS   A ND1  1 
ATOM   2110 C  CD2  . HIS   A 1 295 ? 3.02557   -16.28544 4.69164   1.000 27.99258  ? 300  HIS   A CD2  1 
ATOM   2111 C  CE1  . HIS   A 1 295 ? 3.82037   -18.32852 4.81454   1.000 25.85201  ? 300  HIS   A CE1  1 
ATOM   2112 N  NE2  . HIS   A 1 295 ? 3.13043   -17.41249 5.47458   1.000 27.06232  ? 300  HIS   A NE2  1 
ATOM   2113 N  N    . THR   A 1 296 ? 5.73380   -15.87739 -0.19823  1.000 25.86694  ? 301  THR   A N    1 
ATOM   2114 C  CA   . THR   A 1 296 ? 6.00787   -15.65333 -1.61320  1.000 29.02386  ? 301  THR   A CA   1 
ATOM   2115 C  C    . THR   A 1 296 ? 4.88686   -16.16316 -2.50728  1.000 27.79048  ? 301  THR   A C    1 
ATOM   2116 O  O    . THR   A 1 296 ? 5.07189   -16.27311 -3.72228  1.000 30.06821  ? 301  THR   A O    1 
ATOM   2117 C  CB   . THR   A 1 296 ? 7.32582   -16.32843 -2.01720  1.000 30.07204  ? 301  THR   A CB   1 
ATOM   2118 O  OG1  . THR   A 1 296 ? 7.20568   -17.75843 -1.85029  1.000 32.09164  ? 301  THR   A OG1  1 
ATOM   2119 C  CG2  . THR   A 1 296 ? 8.47285   -15.78360 -1.16712  1.000 27.72308  ? 301  THR   A CG2  1 
ATOM   2120 N  N    . ASP   A 1 297 ? 3.73581   -16.50109 -1.94134  1.000 29.43355  ? 302  ASP   A N    1 
ATOM   2121 C  CA   . ASP   A 1 297 ? 2.58579   -16.95293 -2.71642  1.000 28.71211  ? 302  ASP   A CA   1 
ATOM   2122 C  C    . ASP   A 1 297 ? 1.34978   -16.70786 -1.85645  1.000 30.62887  ? 302  ASP   A C    1 
ATOM   2123 O  O    . ASP   A 1 297 ? 1.44378   -16.28794 -0.69742  1.000 28.71872  ? 302  ASP   A O    1 
ATOM   2124 C  CB   . ASP   A 1 297 ? 2.71966   -18.43191 -3.12950  1.000 28.13323  ? 302  ASP   A CB   1 
ATOM   2125 C  CG   . ASP   A 1 297 ? 1.83467   -18.80875 -4.32256  1.000 31.10929  ? 302  ASP   A CG   1 
ATOM   2126 O  OD1  . ASP   A 1 297 ? 1.04077   -17.95565 -4.77654  1.000 32.19506  ? 302  ASP   A OD1  1 
ATOM   2127 O  OD2  . ASP   A 1 297 ? 1.92358   -19.96973 -4.79863  1.000 29.81237  ? 302  ASP   A OD2  1 
ATOM   2128 N  N    . VAL   A 1 298 ? 0.18578   -16.94871 -2.45051  1.000 27.90888  ? 303  VAL   A N    1 
ATOM   2129 C  CA   . VAL   A 1 298 ? -1.06922  -16.66263 -1.76754  1.000 25.69021  ? 303  VAL   A CA   1 
ATOM   2130 C  C    . VAL   A 1 298 ? -1.01533  -17.22072 -0.36057  1.000 26.54192  ? 303  VAL   A C    1 
ATOM   2131 O  O    . VAL   A 1 298 ? -0.68145  -18.38977 -0.15363  1.000 25.34889  ? 303  VAL   A O    1 
ATOM   2132 C  CB   . VAL   A 1 298 ? -2.24825  -17.26547 -2.54762  1.000 28.12037  ? 303  VAL   A CB   1 
ATOM   2133 C  CG1  . VAL   A 1 298 ? -3.55725  -16.98839 -1.79065  1.000 22.64109  ? 303  VAL   A CG1  1 
ATOM   2134 C  CG2  . VAL   A 1 298 ? -2.27714  -16.71137 -4.02459  1.000 25.13246  ? 303  VAL   A CG2  1 
ATOM   2135 N  N    . VAL   A 1 299 ? -1.34028  -16.38275 0.61547   1.000 22.61076  ? 304  VAL   A N    1 
ATOM   2136 C  CA   . VAL   A 1 299 ? -1.51738  -16.85182 1.97943   1.000 24.62493  ? 304  VAL   A CA   1 
ATOM   2137 C  C    . VAL   A 1 299 ? -2.95043  -17.36569 2.07635   1.000 29.80288  ? 304  VAL   A C    1 
ATOM   2138 O  O    . VAL   A 1 299 ? -3.89136  -16.58661 2.23736   1.000 27.08115  ? 304  VAL   A O    1 
ATOM   2139 C  CB   . VAL   A 1 299 ? -1.22031  -15.75692 2.99651   1.000 29.14950  ? 304  VAL   A CB   1 
ATOM   2140 C  CG1  . VAL   A 1 299 ? -1.47741  -16.26298 4.38947   1.000 24.89814  ? 304  VAL   A CG1  1 
ATOM   2141 C  CG2  . VAL   A 1 299 ? 0.23874   -15.28605 2.81260   1.000 24.05342  ? 304  VAL   A CG2  1 
ATOM   2142 N  N    . ILE   A 1 300 ? -3.11956  -18.68767 1.94326   1.000 24.16482  ? 305  ILE   A N    1 
ATOM   2143 C  CA   . ILE   A 1 300 ? -4.44761  -19.26453 1.85417   1.000 22.16975  ? 305  ILE   A CA   1 
ATOM   2144 C  C    . ILE   A 1 300 ? -4.97270  -19.73156 3.20112   1.000 29.66693  ? 305  ILE   A C    1 
ATOM   2145 O  O    . ILE   A 1 300 ? -6.18373  -19.96545 3.32206   1.000 27.53128  ? 305  ILE   A O    1 
ATOM   2146 C  CB   . ILE   A 1 300 ? -4.46368  -20.40846 0.82110   1.000 26.48585  ? 305  ILE   A CB   1 
ATOM   2147 C  CG1  . ILE   A 1 300 ? -5.89468  -20.57729 0.28003   1.000 27.13336  ? 305  ILE   A CG1  1 
ATOM   2148 C  CG2  . ILE   A 1 300 ? -3.90083  -21.71556 1.43304   1.000 24.39378  ? 305  ILE   A CG2  1 
ATOM   2149 C  CD1  . ILE   A 1 300 ? -6.00872  -21.47720 -0.92203  1.000 27.64589  ? 305  ILE   A CD1  1 
ATOM   2150 N  N    . SER   A 1 301 ? -4.11875  -19.83071 4.22915   1.000 25.87194  ? 306  SER   A N    1 
ATOM   2151 C  CA   . SER   A 1 301 ? -4.56685  -20.30075 5.52710   1.000 24.39192  ? 306  SER   A CA   1 
ATOM   2152 C  C    . SER   A 1 301 ? -3.87481  -19.50489 6.62218   1.000 28.43914  ? 306  SER   A C    1 
ATOM   2153 O  O    . SER   A 1 301 ? -2.69078  -19.17499 6.50724   1.000 27.74674  ? 306  SER   A O    1 
ATOM   2154 C  CB   . SER   A 1 301 ? -4.30600  -21.80979 5.71702   1.000 22.67932  ? 306  SER   A CB   1 
ATOM   2155 O  OG   . SER   A 1 301 ? -4.79609  -22.22282 6.99797   1.000 26.51082  ? 306  SER   A OG   1 
ATOM   2156 N  N    . THR   A 1 302 ? -4.65282  -19.14587 7.64017   1.000 24.57127  ? 307  THR   A N    1 
ATOM   2157 C  CA   . THR   A 1 302 ? -4.15181  -18.55500 8.86523   1.000 25.98676  ? 307  THR   A CA   1 
ATOM   2158 C  C    . THR   A 1 302 ? -4.88191  -19.20700 10.02516  1.000 29.28074  ? 307  THR   A C    1 
ATOM   2159 O  O    . THR   A 1 302 ? -5.98496  -19.74588 9.86708   1.000 29.01391  ? 307  THR   A O    1 
ATOM   2160 C  CB   . THR   A 1 302 ? -4.36066  -17.04298 8.91431   1.000 28.00404  ? 307  THR   A CB   1 
ATOM   2161 O  OG1  . THR   A 1 302 ? -5.75462  -16.74984 8.73528   1.000 28.66669  ? 307  THR   A OG1  1 
ATOM   2162 C  CG2  . THR   A 1 302 ? -3.55955  -16.34799 7.84039   1.000 26.85500  ? 307  THR   A CG2  1 
ATOM   2163 N  N    . ALA   A 1 303 ? -4.24195  -19.16214 11.19019  1.000 28.59527  ? 308  ALA   A N    1 
ATOM   2164 C  CA   . ALA   A 1 303 ? -4.78105  -19.72916 12.41413  1.000 27.16110  ? 308  ALA   A CA   1 
ATOM   2165 C  C    . ALA   A 1 303 ? -4.26902  -18.89628 13.57620  1.000 30.03954  ? 308  ALA   A C    1 
ATOM   2166 O  O    . ALA   A 1 303 ? -3.15296  -18.37139 13.52928  1.000 27.67851  ? 308  ALA   A O    1 
ATOM   2167 C  CB   . ALA   A 1 303 ? -4.38220  -21.20121 12.59405  1.000 28.05540  ? 308  ALA   A CB   1 
ATOM   2168 N  N    . CYS   A 1 304 ? -5.08105  -18.78427 14.62118  1.000 29.63484  ? 309  CYS   A N    1 
ATOM   2169 C  CA   . CYS   A 1 304 ? -4.71202  -18.02438 15.81024  1.000 29.85717  ? 309  CYS   A CA   1 
ATOM   2170 C  C    . CYS   A 1 304 ? -4.55315  -18.96747 16.99719  1.000 31.22991  ? 309  CYS   A C    1 
ATOM   2171 O  O    . CYS   A 1 304 ? -5.40625  -19.82640 17.24110  1.000 29.23279  ? 309  CYS   A O    1 
ATOM   2172 C  CB   . CYS   A 1 304 ? -5.74992  -16.94930 16.11127  1.000 27.86989  ? 309  CYS   A CB   1 
ATOM   2173 S  SG   . CYS   A 1 304 ? -5.92776  -15.74720 14.79034  1.000 33.43857  ? 309  CYS   A SG   1 
ATOM   2174 N  N    . HIS   A 1 305 ? -3.47917  -18.79262 17.74024  1.000 32.30245  ? 310  HIS   A N    1 
ATOM   2175 C  CA   . HIS   A 1 305 ? -3.21329  -19.69972 18.83019  1.000 28.37186  ? 310  HIS   A CA   1 
ATOM   2176 C  C    . HIS   A 1 305 ? -4.28332  -19.55268 19.91816  1.000 35.89190  ? 310  HIS   A C    1 
ATOM   2177 O  O    . HIS   A 1 305 ? -4.80822  -18.45665 20.15121  1.000 32.66258  ? 310  HIS   A O    1 
ATOM   2178 C  CB   . HIS   A 1 305 ? -1.82629  -19.43789 19.39326  1.000 32.72823  ? 310  HIS   A CB   1 
ATOM   2179 C  CG   . HIS   A 1 305 ? -1.41143  -20.43499 20.42221  1.000 36.37063  ? 310  HIS   A CG   1 
ATOM   2180 N  ND1  . HIS   A 1 305 ? -1.82947  -20.36304 21.73520  1.000 35.23165  ? 310  HIS   A ND1  1 
ATOM   2181 C  CD2  . HIS   A 1 305 ? -0.63353  -21.53906 20.33117  1.000 31.80938  ? 310  HIS   A CD2  1 
ATOM   2182 C  CE1  . HIS   A 1 305 ? -1.32959  -21.38313 22.40516  1.000 35.39493  ? 310  HIS   A CE1  1 
ATOM   2183 N  NE2  . HIS   A 1 305 ? -0.60063  -22.11114 21.57814  1.000 31.30932  ? 310  HIS   A NE2  1 
ATOM   2184 N  N    . PRO   A 1 306 ? -4.64445  -20.65369 20.58708  1.000 32.32401  ? 311  PRO   A N    1 
ATOM   2185 C  CA   . PRO   A 1 306 ? -5.79848  -20.60763 21.50304  1.000 38.92718  ? 311  PRO   A CA   1 
ATOM   2186 C  C    . PRO   A 1 306 ? -5.57545  -19.76774 22.75810  1.000 37.21544  ? 311  PRO   A C    1 
ATOM   2187 O  O    . PRO   A 1 306 ? -6.56443  -19.35868 23.38408  1.000 39.45140  ? 311  PRO   A O    1 
ATOM   2188 C  CB   . PRO   A 1 306 ? -6.03264  -22.08963 21.84893  1.000 36.64968  ? 311  PRO   A CB   1 
ATOM   2189 C  CG   . PRO   A 1 306 ? -4.70970  -22.75975 21.59694  1.000 34.36338  ? 311  PRO   A CG   1 
ATOM   2190 C  CD   . PRO   A 1 306 ? -4.11258  -22.01973 20.43201  1.000 29.69849  ? 311  PRO   A CD   1 
ATOM   2191 N  N    . THR   A 1 307 ? -4.32444  -19.48288 23.14216  1.000 37.69023  ? 312  THR   A N    1 
ATOM   2192 C  CA   . THR   A 1 307 ? -4.07341  -18.71798 24.36622  1.000 38.02702  ? 312  THR   A CA   1 
ATOM   2193 C  C    . THR   A 1 307 ? -3.01130  -17.63508 24.23233  1.000 35.23288  ? 312  THR   A C    1 
ATOM   2194 O  O    . THR   A 1 307 ? -3.10223  -16.63811 24.95039  1.000 37.96702  ? 312  THR   A O    1 
ATOM   2195 C  CB   . THR   A 1 307 ? -3.67354  -19.65109 25.53118  1.000 35.87322  ? 312  THR   A CB   1 
ATOM   2196 O  OG1  . THR   A 1 307 ? -2.50860  -20.40419 25.17917  1.000 35.51579  ? 312  THR   A OG1  1 
ATOM   2197 C  CG2  . THR   A 1 307 ? -4.81465  -20.59601 25.89707  1.000 36.32513  ? 312  THR   A CG2  1 
ATOM   2198 N  N    . GLU   A 1 308 ? -2.01228  -17.78112 23.36736  1.000 35.74514  ? 313  GLU   A N    1 
ATOM   2199 C  CA   . GLU   A 1 308 ? -1.00117  -16.75821 23.16046  1.000 31.72404  ? 313  GLU   A CA   1 
ATOM   2200 C  C    . GLU   A 1 308 ? -1.27905  -15.98510 21.87750  1.000 32.50682  ? 313  GLU   A C    1 
ATOM   2201 O  O    . GLU   A 1 308 ? -1.98806  -16.45197 20.98244  1.000 34.21807  ? 313  GLU   A O    1 
ATOM   2202 C  CB   . GLU   A 1 308 ? 0.39277   -17.37834 23.09147  1.000 36.12167  ? 313  GLU   A CB   1 
ATOM   2203 C  CG   . GLU   A 1 308 ? 0.60962   -18.49042 24.08441  1.000 36.36025  ? 313  GLU   A CG   1 
ATOM   2204 C  CD   . GLU   A 1 308 ? 0.31361   -18.06048 25.51243  1.000 47.22402  ? 313  GLU   A CD   1 
ATOM   2205 O  OE1  . GLU   A 1 308 ? 0.72370   -16.94555 25.91951  1.000 44.41718  ? 313  GLU   A OE1  1 
ATOM   2206 O  OE2  . GLU   A 1 308 ? -0.34549  -18.84646 26.22735  1.000 47.97494  ? 313  GLU   A OE2  1 
ATOM   2207 N  N    . ASN   A 1 309 ? -0.70493  -14.78715 21.78959  1.000 35.19217  ? 314  ASN   A N    1 
ATOM   2208 C  CA   . ASN   A 1 309 ? -0.83780  -13.96806 20.58264  1.000 34.56451  ? 314  ASN   A CA   1 
ATOM   2209 C  C    . ASN   A 1 309 ? 0.11518   -14.50608 19.51964  1.000 28.79394  ? 314  ASN   A C    1 
ATOM   2210 O  O    . ASN   A 1 309 ? 1.13226   -13.89916 19.18272  1.000 33.35658  ? 314  ASN   A O    1 
ATOM   2211 C  CB   . ASN   A 1 309 ? -0.54567  -12.50511 20.87574  1.000 33.42091  ? 314  ASN   A CB   1 
ATOM   2212 C  CG   . ASN   A 1 309 ? -1.34767  -11.97310 22.02975  1.000 38.49054  ? 314  ASN   A CG   1 
ATOM   2213 O  OD1  . ASN   A 1 309 ? -2.50871  -12.33900 22.22168  1.000 33.23788  ? 314  ASN   A OD1  1 
ATOM   2214 N  ND2  . ASN   A 1 309 ? -0.73661  -11.08921 22.81083  1.000 40.82975  ? 314  ASN   A ND2  1 
ATOM   2215 N  N    . ILE   A 1 310 ? -0.22391  -15.68102 18.99456  1.000 29.98891  ? 315  ILE   A N    1 
ATOM   2216 C  CA   . ILE   A 1 310 ? 0.57807   -16.33203 17.96455  1.000 31.82015  ? 315  ILE   A CA   1 
ATOM   2217 C  C    . ILE   A 1 310 ? -0.31091  -16.59687 16.76650  1.000 27.41887  ? 315  ILE   A C    1 
ATOM   2218 O  O    . ILE   A 1 310 ? -1.43797  -17.07177 16.92242  1.000 31.49580  ? 315  ILE   A O    1 
ATOM   2219 C  CB   . ILE   A 1 310 ? 1.23092   -17.64613 18.44249  1.000 29.99233  ? 315  ILE   A CB   1 
ATOM   2220 C  CG1  . ILE   A 1 310 ? 2.24690   -17.37029 19.55854  1.000 32.54068  ? 315  ILE   A CG1  1 
ATOM   2221 C  CG2  . ILE   A 1 310 ? 1.94490   -18.31212 17.28247  1.000 28.02131  ? 315  ILE   A CG2  1 
ATOM   2222 C  CD1  . ILE   A 1 310 ? 2.77776   -18.62639 20.23149  1.000 28.52030  ? 315  ILE   A CD1  1 
ATOM   2223 N  N    . ILE   A 1 311 ? 0.20516   -16.29585 15.57753  1.000 29.36023  ? 316  ILE   A N    1 
ATOM   2224 C  CA   . ILE   A 1 311 ? -0.47982  -16.53570 14.31049  1.000 29.65748  ? 316  ILE   A CA   1 
ATOM   2225 C  C    . ILE   A 1 311 ? 0.35112   -17.49573 13.46746  1.000 29.00156  ? 316  ILE   A C    1 
ATOM   2226 O  O    . ILE   A 1 311 ? 1.57114   -17.33384 13.35052  1.000 29.22147  ? 316  ILE   A O    1 
ATOM   2227 C  CB   . ILE   A 1 311 ? -0.71566  -15.22663 13.53157  1.000 29.27579  ? 316  ILE   A CB   1 
ATOM   2228 C  CG1  . ILE   A 1 311 ? -1.84260  -14.39356 14.16958  1.000 24.54269  ? 316  ILE   A CG1  1 
ATOM   2229 C  CG2  . ILE   A 1 311 ? -1.00463  -15.54751 12.06654  1.000 24.25125  ? 316  ILE   A CG2  1 
ATOM   2230 C  CD1  . ILE   A 1 311 ? -1.99044  -13.02150 13.51966  1.000 26.04196  ? 316  ILE   A CD1  1 
ATOM   2231 N  N    . ALA   A 1 312 ? -0.30395  -18.49063 12.87538  1.000 25.87420  ? 317  ALA   A N    1 
ATOM   2232 C  CA   . ALA   A 1 312 ? 0.29901   -19.30462 11.82735  1.000 29.41344  ? 317  ALA   A CA   1 
ATOM   2233 C  C    . ALA   A 1 312 ? -0.30490  -18.91848 10.48335  1.000 25.27292  ? 317  ALA   A C    1 
ATOM   2234 O  O    . ALA   A 1 312 ? -1.52288  -18.72835 10.36432  1.000 27.09085  ? 317  ALA   A O    1 
ATOM   2235 C  CB   . ALA   A 1 312 ? 0.09885   -20.81561 12.06725  1.000 21.97507  ? 317  ALA   A CB   1 
ATOM   2236 N  N    . SER   A 1 313 ? 0.54915   -18.78350 9.48239   1.000 26.71023  ? 318  SER   A N    1 
ATOM   2237 C  CA   . SER   A 1 313 ? 0.10022   -18.60937 8.11038   1.000 27.08322  ? 318  SER   A CA   1 
ATOM   2238 C  C    . SER   A 1 313 ? 0.71215   -19.68637 7.22434   1.000 31.22091  ? 318  SER   A C    1 
ATOM   2239 O  O    . SER   A 1 313 ? 1.81309   -20.17949 7.49635   1.000 29.22587  ? 318  SER   A O    1 
ATOM   2240 C  CB   . SER   A 1 313 ? 0.47337   -17.22737 7.58849   1.000 27.68737  ? 318  SER   A CB   1 
ATOM   2241 O  OG   . SER   A 1 313 ? 1.84039   -16.96452 7.82555   1.000 31.05512  ? 318  SER   A OG   1 
ATOM   2242 N  N    . ALA   A 1 314 ? -0.00785  -20.05223 6.16229   1.000 25.47552  ? 319  ALA   A N    1 
ATOM   2243 C  CA   . ALA   A 1 314 ? 0.48909   -21.01922 5.19025   1.000 26.25636  ? 319  ALA   A CA   1 
ATOM   2244 C  C    . ALA   A 1 314 ? 0.18419   -20.54210 3.77827   1.000 26.96685  ? 319  ALA   A C    1 
ATOM   2245 O  O    . ALA   A 1 314 ? -0.86674  -19.93798 3.52626   1.000 24.10817  ? 319  ALA   A O    1 
ATOM   2246 C  CB   . ALA   A 1 314 ? -0.11905  -22.39217 5.41114   1.000 22.39985  ? 319  ALA   A CB   1 
ATOM   2247 N  N    . ALA   A 1 315 ? 1.09320   -20.85913 2.84728   1.000 26.66387  ? 320  ALA   A N    1 
ATOM   2248 C  CA   . ALA   A 1 315 ? 1.03730   -20.32404 1.49131   1.000 24.88167  ? 320  ALA   A CA   1 
ATOM   2249 C  C    . ALA   A 1 315 ? 1.04223   -21.44298 0.45224   1.000 27.54471  ? 320  ALA   A C    1 
ATOM   2250 O  O    . ALA   A 1 315 ? 1.34511   -22.61102 0.73318   1.000 27.86275  ? 320  ALA   A O    1 
ATOM   2251 C  CB   . ALA   A 1 315 ? 2.19641   -19.34814 1.23442   1.000 27.47388  ? 320  ALA   A CB   1 
ATOM   2252 N  N    . LEU   A 1 316 ? 0.70132   -21.05287 -0.77675  1.000 27.84542  ? 321  LEU   A N    1 
ATOM   2253 C  CA   . LEU   A 1 316 ? 0.46027   -21.99477 -1.87581  1.000 28.44370  ? 321  LEU   A CA   1 
ATOM   2254 C  C    . LEU   A 1 316 ? 1.73924   -22.50786 -2.54380  1.000 26.98062  ? 321  LEU   A C    1 
ATOM   2255 O  O    . LEU   A 1 316 ? 2.83624   -22.38300 -2.00075  1.000 26.03638  ? 321  LEU   A O    1 
ATOM   2256 C  CB   . LEU   A 1 316 ? -0.46463  -21.35262 -2.93181  1.000 27.68260  ? 321  LEU   A CB   1 
ATOM   2257 C  CG   . LEU   A 1 316 ? -1.90862  -21.10951 -2.44985  1.000 23.05697  ? 321  LEU   A CG   1 
ATOM   2258 C  CD1  . LEU   A 1 316 ? -2.77053  -20.55935 -3.59585  1.000 28.07246  ? 321  LEU   A CD1  1 
ATOM   2259 C  CD2  . LEU   A 1 316 ? -2.48177  -22.41548 -1.90895  1.000 21.52888  ? 321  LEU   A CD2  1 
ATOM   2260 N  N    . GLU   A 1 317 ? 1.57823   -23.08576 -3.73484  1.000 27.21623  ? 322  GLU   A N    1 
ATOM   2261 C  CA   . GLU   A 1 317 ? 2.58117   -23.95582 -4.34786  1.000 34.16880  ? 322  GLU   A CA   1 
ATOM   2262 C  C    . GLU   A 1 317 ? 3.94224   -23.28894 -4.52376  1.000 30.71192  ? 322  GLU   A C    1 
ATOM   2263 O  O    . GLU   A 1 317 ? 4.96518   -23.98005 -4.50277  1.000 35.50973  ? 322  GLU   A O    1 
ATOM   2264 C  CB   . GLU   A 1 317 ? 2.07118   -24.43169 -5.71091  1.000 36.83296  ? 322  GLU   A CB   1 
ATOM   2265 C  CG   . GLU   A 1 317 ? 2.81108   -25.62872 -6.29895  1.000 45.97319  ? 322  GLU   A CG   1 
ATOM   2266 C  CD   . GLU   A 1 317 ? 2.41693   -26.95573 -5.64005  1.000 51.53854  ? 322  GLU   A CD   1 
ATOM   2267 O  OE1  . GLU   A 1 317 ? 1.40790   -26.98068 -4.86009  1.000 45.21167  ? 322  GLU   A OE1  1 
ATOM   2268 O  OE2  . GLU   A 1 317 ? 3.11784   -27.96878 -5.91709  1.000 50.07537  ? 322  GLU   A OE2  1 
ATOM   2269 N  N    . ASN   A 1 318 ? 3.98738   -21.97493 -4.75268  1.000 30.38840  ? 323  ASN   A N    1 
ATOM   2270 C  CA   . ASN   A 1 318 ? 5.24846   -21.26904 -4.97559  1.000 35.24218  ? 323  ASN   A CA   1 
ATOM   2271 C  C    . ASN   A 1 318 ? 5.86746   -20.74419 -3.67953  1.000 32.48899  ? 323  ASN   A C    1 
ATOM   2272 O  O    . ASN   A 1 318 ? 6.75954   -19.89127 -3.72344  1.000 29.73021  ? 323  ASN   A O    1 
ATOM   2273 C  CB   . ASN   A 1 318 ? 5.06461   -20.10696 -5.95252  1.000 29.71564  ? 323  ASN   A CB   1 
ATOM   2274 C  CG   . ASN   A 1 318 ? 4.60061   -20.55683 -7.30157  1.000 38.57287  ? 323  ASN   A CG   1 
ATOM   2275 O  OD1  . ASN   A 1 318 ? 4.91652   -21.66184 -7.74662  1.000 38.47133  ? 323  ASN   A OD1  1 
ATOM   2276 N  ND2  . ASN   A 1 318 ? 3.83972   -19.70472 -7.97354  1.000 38.50050  ? 323  ASN   A ND2  1 
ATOM   2277 N  N    . ASP   A 1 319 ? 5.40137   -21.22521 -2.52958  1.000 28.77774  ? 324  ASP   A N    1 
ATOM   2278 C  CA   . ASP   A 1 319 ? 5.97236   -20.83135 -1.25453  1.000 28.95540  ? 324  ASP   A CA   1 
ATOM   2279 C  C    . ASP   A 1 319 ? 6.24020   -22.10942 -0.46360  1.000 30.44631  ? 324  ASP   A C    1 
ATOM   2280 O  O    . ASP   A 1 319 ? 7.39616   -22.41256 -0.14258  1.000 33.66722  ? 324  ASP   A O    1 
ATOM   2281 C  CB   . ASP   A 1 319 ? 5.01943   -19.86030 -0.54351  1.000 26.23543  ? 324  ASP   A CB   1 
ATOM   2282 C  CG   . ASP   A 1 319 ? 5.50041   -19.46043 0.82654   1.000 27.37091  ? 324  ASP   A CG   1 
ATOM   2283 O  OD1  . ASP   A 1 319 ? 5.89529   -20.36452 1.61249   1.000 31.59571  ? 324  ASP   A OD1  1 
ATOM   2284 O  OD2  . ASP   A 1 319 ? 5.46352   -18.24745 1.12561   1.000 30.45285  ? 324  ASP   A OD2  1 
ATOM   2285 N  N    . LYS   A 1 320 ? 5.18912   -22.89934 -0.19969  1.000 29.51908  ? 325  LYS   A N    1 
ATOM   2286 C  CA   . LYS   A 1 320 ? 5.26596   -24.21939 0.43823   1.000 33.56753  ? 325  LYS   A CA   1 
ATOM   2287 C  C    . LYS   A 1 320 ? 5.66191   -24.17052 1.91225   1.000 27.20285  ? 325  LYS   A C    1 
ATOM   2288 O  O    . LYS   A 1 320 ? 5.89479   -25.22758 2.51619   1.000 28.46942  ? 325  LYS   A O    1 
ATOM   2289 C  CB   . LYS   A 1 320 ? 6.24490   -25.15544 -0.28879  1.000 30.34812  ? 325  LYS   A CB   1 
ATOM   2290 C  CG   . LYS   A 1 320 ? 5.97194   -25.33232 -1.76381  1.000 30.24169  ? 325  LYS   A CG   1 
ATOM   2291 C  CD   . LYS   A 1 320 ? 6.81385   -26.47336 -2.32285  1.000 31.95244  ? 325  LYS   A CD   1 
ATOM   2292 C  CE   . LYS   A 1 320 ? 6.64889   -26.62425 -3.83487  1.000 31.52634  ? 325  LYS   A CE   1 
ATOM   2293 N  NZ   . LYS   A 1 320 ? 7.40180   -27.79429 -4.38792  1.000 30.94503  ? 325  LYS   A NZ   1 
ATOM   2294 N  N    . THR   A 1 321 ? 5.72900   -22.99556 2.52132   1.000 26.92856  ? 326  THR   A N    1 
ATOM   2295 C  CA   . THR   A 1 321 ? 6.13096   -22.89369 3.91334   1.000 26.77375  ? 326  THR   A CA   1 
ATOM   2296 C  C    . THR   A 1 321 ? 4.99198   -22.38063 4.78733   1.000 32.18265  ? 326  THR   A C    1 
ATOM   2297 O  O    . THR   A 1 321 ? 4.05406   -21.72651 4.32034   1.000 27.18052  ? 326  THR   A O    1 
ATOM   2298 C  CB   . THR   A 1 321 ? 7.35004   -21.97882 4.06945   1.000 30.32045  ? 326  THR   A CB   1 
ATOM   2299 O  OG1  . THR   A 1 321 ? 6.98119   -20.61177 3.84752   1.000 26.51881  ? 326  THR   A OG1  1 
ATOM   2300 C  CG2  . THR   A 1 321 ? 8.44604   -22.36786 3.08147   1.000 30.73713  ? 326  THR   A CG2  1 
ATOM   2301 N  N    . ILE   A 1 322 ? 5.08690   -22.73272 6.06731   1.000 30.74488  ? 327  ILE   A N    1 
ATOM   2302 C  CA   . ILE   A 1 322 ? 4.25490   -22.21371 7.14232   1.000 29.01304  ? 327  ILE   A CA   1 
ATOM   2303 C  C    . ILE   A 1 322 ? 5.07598   -21.18284 7.89541   1.000 33.37958  ? 327  ILE   A C    1 
ATOM   2304 O  O    . ILE   A 1 322 ? 6.29996   -21.31296 8.01745   1.000 30.40043  ? 327  ILE   A O    1 
ATOM   2305 C  CB   . ILE   A 1 322 ? 3.81376   -23.35373 8.08623   1.000 32.02164  ? 327  ILE   A CB   1 
ATOM   2306 C  CG1  . ILE   A 1 322 ? 2.99569   -24.40160 7.32513   1.000 27.10804  ? 327  ILE   A CG1  1 
ATOM   2307 C  CG2  . ILE   A 1 322 ? 3.08777   -22.78673 9.28924   1.000 25.30317  ? 327  ILE   A CG2  1 
ATOM   2308 C  CD1  . ILE   A 1 322 ? 3.15553   -25.82565 7.83705   1.000 27.82622  ? 327  ILE   A CD1  1 
ATOM   2309 N  N    . LYS   A 1 323 ? 4.42306   -20.14580 8.40945   1.000 26.46334  ? 328  LYS   A N    1 
ATOM   2310 C  CA   . LYS   A 1 323 ? 5.14012   -19.15192 9.20154   1.000 31.03513  ? 328  LYS   A CA   1 
ATOM   2311 C  C    . LYS   A 1 323 ? 4.43010   -18.90394 10.52153  1.000 31.13835  ? 328  LYS   A C    1 
ATOM   2312 O  O    . LYS   A 1 323 ? 3.19110   -18.88182 10.58949  1.000 30.36678  ? 328  LYS   A O    1 
ATOM   2313 C  CB   . LYS   A 1 323 ? 5.31728   -17.83889 8.43263   1.000 25.47770  ? 328  LYS   A CB   1 
ATOM   2314 C  CG   . LYS   A 1 323 ? 6.34731   -17.94992 7.30666   1.000 26.71442  ? 328  LYS   A CG   1 
ATOM   2315 C  CD   . LYS   A 1 323 ? 6.43947   -16.66188 6.48475   1.000 29.91415  ? 328  LYS   A CD   1 
ATOM   2316 C  CE   . LYS   A 1 323 ? 7.21049   -16.91587 5.18176   1.000 32.67202  ? 328  LYS   A CE   1 
ATOM   2317 N  NZ   . LYS   A 1 323 ? 8.69948   -16.98403 5.41881   1.000 33.23878  ? 328  LYS   A NZ   1 
ATOM   2318 N  N    . LEU   A 1 324 ? 5.22608   -18.72308 11.56557  1.000 29.32749  ? 329  LEU   A N    1 
ATOM   2319 C  CA   . LEU   A 1 324 ? 4.72205   -18.47512 12.90457  1.000 29.40050  ? 329  LEU   A CA   1 
ATOM   2320 C  C    . LEU   A 1 324 ? 5.11717   -17.06818 13.31267  1.000 32.11886  ? 329  LEU   A C    1 
ATOM   2321 O  O    . LEU   A 1 324 ? 6.28121   -16.68628 13.16974  1.000 30.41433  ? 329  LEU   A O    1 
ATOM   2322 C  CB   . LEU   A 1 324 ? 5.26891   -19.50323 13.90152  1.000 30.85744  ? 329  LEU   A CB   1 
ATOM   2323 C  CG   . LEU   A 1 324 ? 4.72878   -20.92917 13.75541  1.000 34.53612  ? 329  LEU   A CG   1 
ATOM   2324 C  CD1  . LEU   A 1 324 ? 5.52165   -21.91230 14.62138  1.000 33.14883  ? 329  LEU   A CD1  1 
ATOM   2325 C  CD2  . LEU   A 1 324 ? 3.25076   -20.96905 14.13336  1.000 31.06030  ? 329  LEU   A CD2  1 
ATOM   2326 N  N    . TRP   A 1 325 ? 4.14723   -16.30512 13.81268  1.000 26.95122  ? 330  TRP   A N    1 
ATOM   2327 C  CA   . TRP   A 1 325 ? 4.32535   -14.90416 14.15578  1.000 26.79341  ? 330  TRP   A CA   1 
ATOM   2328 C  C    . TRP   A 1 325 ? 3.82032   -14.67620 15.57177  1.000 29.27647  ? 330  TRP   A C    1 
ATOM   2329 O  O    . TRP   A 1 325 ? 2.84224   -15.29313 16.00970  1.000 28.85552  ? 330  TRP   A O    1 
ATOM   2330 C  CB   . TRP   A 1 325 ? 3.56248   -13.96802 13.20481  1.000 26.30587  ? 330  TRP   A CB   1 
ATOM   2331 C  CG   . TRP   A 1 325 ? 3.55649   -14.35693 11.76578  1.000 31.27681  ? 330  TRP   A CG   1 
ATOM   2332 C  CD1  . TRP   A 1 325 ? 2.89341   -15.41883 11.19769  1.000 29.20429  ? 330  TRP   A CD1  1 
ATOM   2333 C  CD2  . TRP   A 1 325 ? 4.21960   -13.67793 10.68685  1.000 28.20823  ? 330  TRP   A CD2  1 
ATOM   2334 N  NE1  . TRP   A 1 325 ? 3.10646   -15.43577 9.83370   1.000 25.75894  ? 330  TRP   A NE1  1 
ATOM   2335 C  CE2  . TRP   A 1 325 ? 3.90858   -14.37782 9.49480   1.000 28.04971  ? 330  TRP   A CE2  1 
ATOM   2336 C  CE3  . TRP   A 1 325 ? 5.03271   -12.54400 10.61195  1.000 32.63868  ? 330  TRP   A CE3  1 
ATOM   2337 C  CZ2  . TRP   A 1 325 ? 4.39466   -13.98179 8.23984   1.000 30.29250  ? 330  TRP   A CZ2  1 
ATOM   2338 C  CZ3  . TRP   A 1 325 ? 5.50580   -12.14797 9.35600   1.000 31.11554  ? 330  TRP   A CZ3  1 
ATOM   2339 C  CH2  . TRP   A 1 325 ? 5.19577   -12.86987 8.19894   1.000 30.70067  ? 330  TRP   A CH2  1 
ATOM   2340 N  N    . LYS   A 1 326 ? 4.47238   -13.76530 16.27586  1.000 31.40864  ? 331  LYS   A N    1 
ATOM   2341 C  CA   . LYS   A 1 326 ? 4.15535   -13.53536 17.67386  1.000 30.93900  ? 331  LYS   A CA   1 
ATOM   2342 C  C    . LYS   A 1 326 ? 4.05648   -12.04037 17.90895  1.000 29.97942  ? 331  LYS   A C    1 
ATOM   2343 O  O    . LYS   A 1 326 ? 4.83858   -11.26041 17.35203  1.000 28.50548  ? 331  LYS   A O    1 
ATOM   2344 C  CB   . LYS   A 1 326 ? 5.20425   -14.15952 18.61586  1.000 32.53129  ? 331  LYS   A CB   1 
ATOM   2345 C  CG   . LYS   A 1 326 ? 5.01824   -13.75460 20.09288  1.000 33.20598  ? 331  LYS   A CG   1 
ATOM   2346 C  CD   . LYS   A 1 326 ? 4.97608   -14.97365 21.00980  1.000 36.79064  ? 331  LYS   A CD   1 
ATOM   2347 C  CE   . LYS   A 1 326 ? 5.49706   -14.68079 22.42984  1.000 39.48766  ? 331  LYS   A CE   1 
ATOM   2348 N  NZ   . LYS   A 1 326 ? 5.05316   -13.36678 22.95790  1.000 42.23185  ? 331  LYS   A NZ   1 
ATOM   2349 N  N    . SER   A 1 327 ? 3.07349   -11.65332 18.71894  1.000 28.74508  ? 332  SER   A N    1 
ATOM   2350 C  CA   . SER   A 1 327 ? 2.79062   -10.25531 19.00501  1.000 32.97855  ? 332  SER   A CA   1 
ATOM   2351 C  C    . SER   A 1 327 ? 2.68058   -10.05240 20.51002  1.000 32.04794  ? 332  SER   A C    1 
ATOM   2352 O  O    . SER   A 1 327 ? 2.31046   -10.96641 21.24695  1.000 31.03994  ? 332  SER   A O    1 
ATOM   2353 C  CB   . SER   A 1 327 ? 1.48169   -9.81114  18.30799  1.000 33.99602  ? 332  SER   A CB   1 
ATOM   2354 O  OG   . SER   A 1 327 ? 1.15081   -8.46613  18.60206  1.000 37.26044  ? 332  SER   A OG   1 
ATOM   2355 N  N    . ASP   A 1 328 ? 2.98468   -8.83245  20.95811  1.000 38.84073  ? 333  ASP   A N    1 
ATOM   2356 C  CA   . ASP   A 1 328 ? 2.86566   -8.51253  22.37712  1.000 35.30409  ? 333  ASP   A CA   1 
ATOM   2357 C  C    . ASP   A 1 328 ? 1.43367   -8.22942  22.80909  1.000 41.16143  ? 333  ASP   A C    1 
ATOM   2358 O  O    . ASP   A 1 328 ? 1.15462   -8.23647  24.01308  1.000 40.99868  ? 333  ASP   A O    1 
ATOM   2359 C  CB   . ASP   A 1 328 ? 3.74976   -7.31464  22.71523  1.000 35.67027  ? 333  ASP   A CB   1 
ATOM   2360 C  CG   . ASP   A 1 328 ? 5.21174   -7.60577  22.47927  1.000 35.24630  ? 333  ASP   A CG   1 
ATOM   2361 O  OD1  . ASP   A 1 328 ? 5.66462   -8.69084  22.91422  1.000 35.39169  ? 333  ASP   A OD1  1 
ATOM   2362 O  OD2  . ASP   A 1 328 ? 5.87785   -6.78879  21.81835  1.000 39.89309  ? 333  ASP   A OD2  1 
ATOM   2363 N  N    . CYS   A 1 329 ? 0.52373   -7.97427  21.86407  1.000 39.22474  ? 334  CYS   A N    1 
ATOM   2364 C  CA   . CYS   A 1 329 ? -0.87826  -7.69316  22.20203  1.000 42.63072  ? 334  CYS   A CA   1 
ATOM   2365 C  C    . CYS   A 1 329 ? -1.82127  -8.23400  21.12696  1.000 45.05767  ? 334  CYS   A C    1 
ATOM   2366 O  O    . CYS   A 1 329 ? -1.38529  -8.86998  20.15394  1.000 42.15824  ? 334  CYS   A O    1 
ATOM   2367 C  CB   . CYS   A 1 329 ? -1.10412  -6.19015  22.38812  1.000 40.39499  ? 334  CYS   A CB   1 
ATOM   2368 S  SG   . CYS   A 1 329 ? -0.72996  -5.16309  20.94120  1.000 48.02508  ? 334  CYS   A SG   1 
ATOM   2369 O  OXT  . CYS   A 1 329 ? -3.04025  -8.05688  21.20993  1.000 47.60291  ? 334  CYS   A OXT  1 
ATOM   2370 N  N    . ALA   B 2 27  ? 7.06467   -20.87908 -43.94044 1.000 56.11932  ? 1079 ALA   B N    1 
ATOM   2371 C  CA   . ALA   B 2 27  ? 5.72462   -21.37201 -44.26235 1.000 58.73784  ? 1079 ALA   B CA   1 
ATOM   2372 C  C    . ALA   B 2 27  ? 4.66070   -20.67986 -43.40837 1.000 59.27245  ? 1079 ALA   B C    1 
ATOM   2373 O  O    . ALA   B 2 27  ? 3.48269   -20.63981 -43.78333 1.000 59.19194  ? 1079 ALA   B O    1 
ATOM   2374 C  CB   . ALA   B 2 27  ? 5.64952   -22.88599 -44.07423 1.000 51.25409  ? 1079 ALA   B CB   1 
ATOM   2375 N  N    . PHE   B 2 28  ? 5.08578   -20.14580 -42.26143 1.000 53.03199  ? 1080 PHE   B N    1 
ATOM   2376 C  CA   . PHE   B 2 28  ? 4.21187   -19.41567 -41.33945 1.000 49.42371  ? 1080 PHE   B CA   1 
ATOM   2377 C  C    . PHE   B 2 28  ? 4.90598   -18.10669 -40.98058 1.000 45.33724  ? 1080 PHE   B C    1 
ATOM   2378 O  O    . PHE   B 2 28  ? 5.77101   -18.06868 -40.09462 1.000 49.97613  ? 1080 PHE   B O    1 
ATOM   2379 C  CB   . PHE   B 2 28  ? 3.88785   -20.25355 -40.09938 1.000 43.84612  ? 1080 PHE   B CB   1 
ATOM   2380 C  CG   . PHE   B 2 28  ? 3.13475   -21.51052 -40.42225 1.000 46.00635  ? 1080 PHE   B CG   1 
ATOM   2381 C  CD1  . PHE   B 2 28  ? 1.77074   -21.47144 -40.65320 1.000 46.40285  ? 1080 PHE   B CD1  1 
ATOM   2382 C  CD2  . PHE   B 2 28  ? 3.79966   -22.72057 -40.55418 1.000 51.14328  ? 1080 PHE   B CD2  1 
ATOM   2383 C  CE1  . PHE   B 2 28  ? 1.07465   -22.62141 -40.98709 1.000 47.76384  ? 1080 PHE   B CE1  1 
ATOM   2384 C  CE2  . PHE   B 2 28  ? 3.11556   -23.87955 -40.88506 1.000 49.46621  ? 1080 PHE   B CE2  1 
ATOM   2385 C  CZ   . PHE   B 2 28  ? 1.74856   -23.83047 -41.10302 1.000 47.93794  ? 1080 PHE   B CZ   1 
ATOM   2386 N  N    . ARG   B 2 29  ? 4.52903   -17.04172 -41.68165 1.000 41.59093  ? 1081 ARG   B N    1 
ATOM   2387 C  CA   . ARG   B 2 29  ? 5.13913   -15.73774 -41.47078 1.000 46.43117  ? 1081 ARG   B CA   1 
ATOM   2388 C  C    . ARG   B 2 29  ? 4.36922   -14.97760 -40.39781 1.000 39.41076  ? 1081 ARG   B C    1 
ATOM   2389 O  O    . ARG   B 2 29  ? 3.15523   -14.77153 -40.54578 1.000 39.79816  ? 1081 ARG   B O    1 
ATOM   2390 C  CB   . ARG   B 2 29  ? 5.15614   -14.92885 -42.76084 1.000 47.69317  ? 1081 ARG   B CB   1 
ATOM   2391 C  CG   . ARG   B 2 29  ? 5.77725   -13.54088 -42.60198 1.000 47.94444  ? 1081 ARG   B CG   1 
ATOM   2392 C  CD   . ARG   B 2 29  ? 5.96125   -12.85800 -43.95304 1.000 47.36310  ? 1081 ARG   B CD   1 
ATOM   2393 N  NE   . ARG   B 2 29  ? 4.68825   -12.52496 -44.58502 1.000 48.72027  ? 1081 ARG   B NE   1 
ATOM   2394 C  CZ   . ARG   B 2 29  ? 4.08334   -11.34491 -44.48709 1.000 58.74295  ? 1081 ARG   B CZ   1 
ATOM   2395 N  NH1  . ARG   B 2 29  ? 4.59944   -10.36089 -43.76018 1.000 55.97361  ? 1081 ARG   B NH1  1 
ATOM   2396 N  NH2  . ARG   B 2 29  ? 2.93333   -11.14787 -45.13306 1.000 52.56942  ? 1081 ARG   B NH2  1 
ATOM   2397 N  N    . PRO   B 2 30  ? 5.01729   -14.54757 -39.32487 1.000 42.70941  ? 1082 PRO   B N    1 
ATOM   2398 C  CA   . PRO   B 2 30  ? 4.33039   -13.72644 -38.32091 1.000 38.04997  ? 1082 PRO   B CA   1 
ATOM   2399 C  C    . PRO   B 2 30  ? 3.71045   -12.49744 -38.96498 1.000 39.36354  ? 1082 PRO   B C    1 
ATOM   2400 O  O    . PRO   B 2 30  ? 4.34247   -11.80455 -39.76606 1.000 45.68575  ? 1082 PRO   B O    1 
ATOM   2401 C  CB   . PRO   B 2 30  ? 5.44145   -13.35644 -37.33298 1.000 43.80677  ? 1082 PRO   B CB   1 
ATOM   2402 C  CG   . PRO   B 2 30  ? 6.46936   -14.46353 -37.49193 1.000 43.36310  ? 1082 PRO   B CG   1 
ATOM   2403 C  CD   . PRO   B 2 30  ? 6.39428   -14.82964 -38.95890 1.000 41.05236  ? 1082 PRO   B CD   1 
ATOM   2404 N  N    . ILE   B 2 31  ? 2.44848   -12.24433 -38.63396 1.000 37.83796  ? 1083 ILE   B N    1 
ATOM   2405 C  CA   . ILE   B 2 31  ? 1.68954   -11.13731 -39.19702 1.000 33.75005  ? 1083 ILE   B CA   1 
ATOM   2406 C  C    . ILE   B 2 31  ? 1.26065   -10.14320 -38.12408 1.000 35.47047  ? 1083 ILE   B C    1 
ATOM   2407 O  O    . ILE   B 2 31  ? 1.24673   -8.93122  -38.35818 1.000 36.84932  ? 1083 ILE   B O    1 
ATOM   2408 C  CB   . ILE   B 2 31  ? 0.45848   -11.66129 -39.97293 1.000 35.86375  ? 1083 ILE   B CB   1 
ATOM   2409 C  CG1  . ILE   B 2 31  ? 0.90938   -12.34342 -41.25590 1.000 45.35191  ? 1083 ILE   B CG1  1 
ATOM   2410 C  CG2  . ILE   B 2 31  ? -0.52545  -10.54024 -40.27299 1.000 41.05619  ? 1083 ILE   B CG2  1 
ATOM   2411 C  CD1  . ILE   B 2 31  ? 2.01241   -11.58656 -41.96800 1.000 44.82874  ? 1083 ILE   B CD1  1 
ATOM   2412 N  N    . SER   B 2 32  ? 0.92566   -10.63308 -36.93403 1.000 33.07962  ? 1084 SER   B N    1 
ATOM   2413 C  CA   . SER   B 2 32  ? 0.38876   -9.79996  -35.87508 1.000 33.22792  ? 1084 SER   B CA   1 
ATOM   2414 C  C    . SER   B 2 32  ? 0.53475   -10.55186 -34.55902 1.000 33.00472  ? 1084 SER   B C    1 
ATOM   2415 O  O    . SER   B 2 32  ? 0.60966   -11.78587 -34.52893 1.000 28.39351  ? 1084 SER   B O    1 
ATOM   2416 C  CB   . SER   B 2 32  ? -1.07623  -9.44987  -36.14005 1.000 23.22965  ? 1084 SER   B CB   1 
ATOM   2417 O  OG   . SER   B 2 32  ? -1.53213  -8.55976  -35.16911 1.000 27.45582  ? 1084 SER   B OG   1 
ATOM   2418 N  N    . VAL   B 2 33  ? 0.58384   -9.78978  -33.47109 1.000 28.98513  ? 1085 VAL   B N    1 
ATOM   2419 C  CA   . VAL   B 2 33  ? 0.59985   -10.37268 -32.13404 1.000 26.95102  ? 1085 VAL   B CA   1 
ATOM   2420 C  C    . VAL   B 2 33  ? -0.15405  -9.42855  -31.21409 1.000 31.64487  ? 1085 VAL   B C    1 
ATOM   2421 O  O    . VAL   B 2 33  ? -0.12897  -8.20757  -31.40319 1.000 26.62748  ? 1085 VAL   B O    1 
ATOM   2422 C  CB   . VAL   B 2 33  ? 2.03785   -10.63074 -31.62907 1.000 29.54788  ? 1085 VAL   B CB   1 
ATOM   2423 C  CG1  . VAL   B 2 33  ? 2.81895   -9.28979  -31.48121 1.000 26.98071  ? 1085 VAL   B CG1  1 
ATOM   2424 C  CG2  . VAL   B 2 33  ? 2.01084   -11.41164 -30.31701 1.000 27.49697  ? 1085 VAL   B CG2  1 
ATOM   2425 N  N    . PHE   B 2 34  ? -0.84405  -10.00042 -30.21802 1.000 30.77911  ? 1086 PHE   B N    1 
ATOM   2426 C  CA   . PHE   B 2 34  ? -1.51196  -9.16130  -29.23706 1.000 29.14589  ? 1086 PHE   B CA   1 
ATOM   2427 C  C    . PHE   B 2 34  ? -1.79497  -9.95417  -27.97199 1.000 32.70525  ? 1086 PHE   B C    1 
ATOM   2428 O  O    . PHE   B 2 34  ? -1.97706  -11.17616 -27.99689 1.000 26.16703  ? 1086 PHE   B O    1 
ATOM   2429 C  CB   . PHE   B 2 34  ? -2.80193  -8.54525  -29.79106 1.000 23.50723  ? 1086 PHE   B CB   1 
ATOM   2430 C  CG   . PHE   B 2 34  ? -3.82502  -9.54821  -30.26895 1.000 29.67952  ? 1086 PHE   B CG   1 
ATOM   2431 C  CD1  . PHE   B 2 34  ? -3.79611  -10.02932 -31.57591 1.000 30.46793  ? 1086 PHE   B CD1  1 
ATOM   2432 C  CD2  . PHE   B 2 34  ? -4.84902  -9.96907  -29.42488 1.000 28.96034  ? 1086 PHE   B CD2  1 
ATOM   2433 C  CE1  . PHE   B 2 34  ? -4.76319  -10.93328 -32.02781 1.000 28.81681  ? 1086 PHE   B CE1  1 
ATOM   2434 C  CE2  . PHE   B 2 34  ? -5.81610  -10.85603 -29.85477 1.000 22.64640  ? 1086 PHE   B CE2  1 
ATOM   2435 C  CZ   . PHE   B 2 34  ? -5.78119  -11.34914 -31.15874 1.000 26.77377  ? 1086 PHE   B CZ   1 
ATOM   2436 N  N    . ARG   B 2 35  ? -1.80888  -9.24009  -26.86404 1.000 29.67236  ? 1087 ARG   B N    1 
ATOM   2437 C  CA   . ARG   B 2 35  ? -2.13788  -9.82096  -25.57499 1.000 29.77295  ? 1087 ARG   B CA   1 
ATOM   2438 C  C    . ARG   B 2 35  ? -3.48782  -9.27883  -25.13298 1.000 31.56915  ? 1087 ARG   B C    1 
ATOM   2439 O  O    . ARG   B 2 35  ? -4.07678  -8.43484  -25.80603 1.000 29.04583  ? 1087 ARG   B O    1 
ATOM   2440 C  CB   . ARG   B 2 35  ? -1.04282  -9.52096  -24.55305 1.000 32.49126  ? 1087 ARG   B CB   1 
ATOM   2441 C  CG   . ARG   B 2 35  ? -0.78670  -8.05396  -24.31917 1.000 32.80997  ? 1087 ARG   B CG   1 
ATOM   2442 C  CD   . ARG   B 2 35  ? 0.52334   -7.88599  -23.54724 1.000 35.95632  ? 1087 ARG   B CD   1 
ATOM   2443 N  NE   . ARG   B 2 35  ? 0.53333   -8.61389  -22.28318 1.000 34.76075  ? 1087 ARG   B NE   1 
ATOM   2444 C  CZ   . ARG   B 2 35  ? -0.10560  -8.22276  -21.19619 1.000 39.45470  ? 1087 ARG   B CZ   1 
ATOM   2445 N  NH1  . ARG   B 2 35  ? -0.91953  -7.17870  -21.21724 1.000 46.39706  ? 1087 ARG   B NH1  1 
ATOM   2446 N  NH2  . ARG   B 2 35  ? 0.07139   -8.89568  -20.06114 1.000 36.06374  ? 1087 ARG   B NH2  1 
ATOM   2447 N  N    . GLU   B 2 36  ? -4.01182  -9.80970  -24.01992 1.000 28.73475  ? 1088 GLU   B N    1 
ATOM   2448 C  CA   . GLU   B 2 36  ? -5.34478  -9.41257  -23.58890 1.000 31.20424  ? 1088 GLU   B CA   1 
ATOM   2449 C  C    . GLU   B 2 36  ? -5.31165  -8.00253  -23.02602 1.000 28.84914  ? 1088 GLU   B C    1 
ATOM   2450 O  O    . GLU   B 2 36  ? -4.44360  -7.66753  -22.21908 1.000 33.63837  ? 1088 GLU   B O    1 
ATOM   2451 C  CB   . GLU   B 2 36  ? -5.89781  -10.37045 -22.53881 1.000 31.35181  ? 1088 GLU   B CB   1 
ATOM   2452 C  CG   . GLU   B 2 36  ? -7.24376  -9.93131  -22.01680 1.000 31.44354  ? 1088 GLU   B CG   1 
ATOM   2453 C  CD   . GLU   B 2 36  ? -7.83079  -10.93419 -21.03470 1.000 35.36301  ? 1088 GLU   B CD   1 
ATOM   2454 O  OE1  . GLU   B 2 36  ? -7.06884  -11.76720 -20.49266 1.000 35.23977  ? 1088 GLU   B OE1  1 
ATOM   2455 O  OE2  . GLU   B 2 36  ? -9.05378  -10.88708 -20.81366 1.000 36.06539  ? 1088 GLU   B OE2  1 
ATOM   2456 N  N    . ALA   B 2 37  ? -6.26861  -7.18849  -23.43805 1.000 28.97171  ? 1089 ALA   B N    1 
ATOM   2457 C  CA   . ALA   B 2 37  ? -6.32049  -5.81145  -22.97315 1.000 38.00125  ? 1089 ALA   B CA   1 
ATOM   2458 C  C    . ALA   B 2 37  ? -6.78344  -5.74630  -21.52114 1.000 43.45098  ? 1089 ALA   B C    1 
ATOM   2459 O  O    . ALA   B 2 37  ? -7.63148  -6.52921  -21.08705 1.000 46.73076  ? 1089 ALA   B O    1 
ATOM   2460 C  CB   . ALA   B 2 37  ? -7.26247  -4.99345  -23.85619 1.000 32.24719  ? 1089 ALA   B CB   1 
ATOM   2461 N  N    . ASN   B 2 38  ? -6.21934  -4.80228  -20.76224 1.000 53.12354  ? 1090 ASN   B N    1 
ATOM   2462 C  CA   . ASN   B 2 38  ? -6.72227  -4.47714  -19.42025 1.000 57.91319  ? 1090 ASN   B CA   1 
ATOM   2463 C  C    . ASN   B 2 38  ? -6.49632  -5.62508  -18.43516 1.000 57.93304  ? 1090 ASN   B C    1 
ATOM   2464 O  O    . ASN   B 2 38  ? -7.38131  -5.95095  -17.64311 1.000 59.23569  ? 1090 ASN   B O    1 
ATOM   2465 C  CB   . ASN   B 2 38  ? -8.21425  -4.12204  -19.45322 1.000 53.85526  ? 1090 ASN   B CB   1 
ATOM   2466 C  CG   . ASN   B 2 38  ? -8.55621  -3.10410  -20.52629 1.000 60.28360  ? 1090 ASN   B CG   1 
ATOM   2467 O  OD1  . ASN   B 2 38  ? -7.87514  -2.08416  -20.67039 1.000 60.33224  ? 1090 ASN   B OD1  1 
ATOM   2468 N  ND2  . ASN   B 2 38  ? -9.62326  -3.37608  -21.29023 1.000 51.74813  ? 1090 ASN   B ND2  1 
ATOM   2469 N  N    . GLU   B 2 39  ? -5.32636  -6.25617  -18.48016 1.000 49.27282  ? 1091 GLU   B N    1 
ATOM   2470 C  CA   . GLU   B 2 39  ? -5.09642  -7.39212  -17.59907 1.000 54.46969  ? 1091 GLU   B CA   1 
ATOM   2471 C  C    . GLU   B 2 39  ? -3.61841  -7.48820  -17.26412 1.000 54.98207  ? 1091 GLU   B C    1 
ATOM   2472 O  O    . GLU   B 2 39  ? -2.77444  -7.45733  -18.16615 1.000 52.30548  ? 1091 GLU   B O    1 
ATOM   2473 C  CB   . GLU   B 2 39  ? -5.59553  -8.69613  -18.23995 1.000 49.51858  ? 1091 GLU   B CB   1 
ATOM   2474 C  CG   . GLU   B 2 39  ? -7.11354  -8.73904  -18.44090 1.000 46.80880  ? 1091 GLU   B CG   1 
ATOM   2475 C  CD   . GLU   B 2 39  ? -7.87050  -8.78088  -17.12786 1.000 57.07878  ? 1091 GLU   B CD   1 
ATOM   2476 O  OE1  . GLU   B 2 39  ? -7.20047  -8.86284  -16.07388 1.000 62.18246  ? 1091 GLU   B OE1  1 
ATOM   2477 O  OE2  . GLU   B 2 39  ? -9.12850  -8.73179  -17.14582 1.000 53.77479  ? 1091 GLU   B OE2  1 
ATOM   2478 N  N    . ASP   B 2 40  ? -3.31137  -7.59512  -15.96712 1.000 59.13451  ? 1092 ASP   B N    1 
ATOM   2479 C  CA   . ASP   B 2 40  ? -1.93137  -7.79918  -15.54015 1.000 60.72421  ? 1092 ASP   B CA   1 
ATOM   2480 C  C    . ASP   B 2 40  ? -1.29548  -8.93929  -16.31709 1.000 53.49408  ? 1092 ASP   B C    1 
ATOM   2481 O  O    . ASP   B 2 40  ? -0.31149  -8.75542  -17.03714 1.000 53.80632  ? 1092 ASP   B O    1 
ATOM   2482 C  CB   . ASP   B 2 40  ? -1.88134  -8.08707  -14.03513 1.000 61.75281  ? 1092 ASP   B CB   1 
ATOM   2483 C  CG   . ASP   B 2 40  ? -2.10322  -6.84298  -13.18522 1.000 75.27451  ? 1092 ASP   B CG   1 
ATOM   2484 O  OD1  . ASP   B 2 40  ? -2.52816  -5.80400  -13.74429 1.000 79.17565  ? 1092 ASP   B OD1  1 
ATOM   2485 O  OD2  . ASP   B 2 40  ? -1.84518  -6.90890  -11.95823 1.000 80.97308  ? 1092 ASP   B OD2  1 
ATOM   2486 N  N    . GLU   B 2 41  ? -1.84456  -10.13724 -16.16597 1.000 50.04795  ? 1093 GLU   B N    1 
ATOM   2487 C  CA   . GLU   B 2 41  ? -1.41567  -11.30333 -16.91490 1.000 47.77261  ? 1093 GLU   B CA   1 
ATOM   2488 C  C    . GLU   B 2 41  ? -2.47673  -11.59333 -17.96783 1.000 42.10634  ? 1093 GLU   B C    1 
ATOM   2489 O  O    . GLU   B 2 41  ? -3.67272  -11.60522 -17.65979 1.000 38.62115  ? 1093 GLU   B O    1 
ATOM   2490 C  CB   . GLU   B 2 41  ? -1.21773  -12.50127 -15.98681 1.000 51.35593  ? 1093 GLU   B CB   1 
ATOM   2491 C  CG   . GLU   B 2 41  ? -0.36066  -12.21723 -14.74086 1.000 57.76197  ? 1093 GLU   B CG   1 
ATOM   2492 C  CD   . GLU   B 2 41  ? 1.13731   -12.41936 -14.97490 1.000 65.98129  ? 1093 GLU   B CD   1 
ATOM   2493 O  OE1  . GLU   B 2 41  ? 1.50624   -12.97647 -16.03887 1.000 65.23367  ? 1093 GLU   B OE1  1 
ATOM   2494 O  OE2  . GLU   B 2 41  ? 1.94537   -12.02435 -14.09396 1.000 67.94781  ? 1093 GLU   B OE2  1 
ATOM   2495 N  N    . SER   B 2 42  ? -2.04279  -11.80446 -19.20083 1.000 34.92352  ? 1094 SER   B N    1 
ATOM   2496 C  CA   . SER   B 2 42  ? -2.96685  -11.99448 -20.31279 1.000 34.51419  ? 1094 SER   B CA   1 
ATOM   2497 C  C    . SER   B 2 42  ? -3.56994  -13.39443 -20.23965 1.000 29.87675  ? 1094 SER   B C    1 
ATOM   2498 O  O    . SER   B 2 42  ? -2.84501  -14.37647 -20.07460 1.000 29.71443  ? 1094 SER   B O    1 
ATOM   2499 C  CB   . SER   B 2 42  ? -2.23388  -11.77864 -21.64283 1.000 29.23023  ? 1094 SER   B CB   1 
ATOM   2500 O  OG   . SER   B 2 42  ? -3.09493  -12.02167 -22.73478 1.000 28.09903  ? 1094 SER   B OG   1 
ATOM   2501 N  N    . GLY   B 2 43  ? -4.89095  -13.48535 -20.35960 1.000 32.06734  ? 1095 GLY   B N    1 
ATOM   2502 C  CA   . GLY   B 2 43  ? -5.54004  -14.75628 -20.08548 1.000 33.37657  ? 1095 GLY   B CA   1 
ATOM   2503 C  C    . GLY   B 2 43  ? -6.25513  -15.46532 -21.22039 1.000 28.36112  ? 1095 GLY   B C    1 
ATOM   2504 O  O    . GLY   B 2 43  ? -7.19517  -16.22023 -20.95530 1.000 27.46323  ? 1095 GLY   B O    1 
ATOM   2505 N  N    . PHE   B 2 44  ? -5.84916  -15.22945 -22.47243 1.000 24.97384  ? 1096 PHE   B N    1 
ATOM   2506 C  CA   . PHE   B 2 44  ? -6.40825  -15.97150 -23.60335 1.000 25.37571  ? 1096 PHE   B CA   1 
ATOM   2507 C  C    . PHE   B 2 44  ? -6.19635  -17.47350 -23.41524 1.000 25.51250  ? 1096 PHE   B C    1 
ATOM   2508 O  O    . PHE   B 2 44  ? -5.09037  -17.90355 -23.08524 1.000 23.48599  ? 1096 PHE   B O    1 
ATOM   2509 C  CB   . PHE   B 2 44  ? -5.74127  -15.54065 -24.91141 1.000 25.47981  ? 1096 PHE   B CB   1 
ATOM   2510 C  CG   . PHE   B 2 44  ? -6.02318  -14.11566 -25.33151 1.000 25.37404  ? 1096 PHE   B CG   1 
ATOM   2511 C  CD1  . PHE   B 2 44  ? -7.25313  -13.52755 -25.09451 1.000 25.57463  ? 1096 PHE   B CD1  1 
ATOM   2512 C  CD2  . PHE   B 2 44  ? -5.05215  -13.38678 -26.00960 1.000 27.03421  ? 1096 PHE   B CD2  1 
ATOM   2513 C  CE1  . PHE   B 2 44  ? -7.50705  -12.23257 -25.52060 1.000 27.91321  ? 1096 PHE   B CE1  1 
ATOM   2514 C  CE2  . PHE   B 2 44  ? -5.29907  -12.08180 -26.43870 1.000 25.02665  ? 1096 PHE   B CE2  1 
ATOM   2515 C  CZ   . PHE   B 2 44  ? -6.51302  -11.51069 -26.19570 1.000 25.45593  ? 1096 PHE   B CZ   1 
ATOM   2516 N  N    . THR   B 2 45  ? -7.24542  -18.28144 -23.66314 1.000 24.73209  ? 1097 THR   B N    1 
ATOM   2517 C  CA   . THR   B 2 45  ? -7.10052  -19.74244 -23.59302 1.000 28.50995  ? 1097 THR   B CA   1 
ATOM   2518 C  C    . THR   B 2 45  ? -7.46662  -20.48752 -24.87395 1.000 24.71094  ? 1097 THR   B C    1 
ATOM   2519 O  O    . THR   B 2 45  ? -6.97071  -21.59057 -25.09288 1.000 24.36256  ? 1097 THR   B O    1 
ATOM   2520 C  CB   . THR   B 2 45  ? -7.95552  -20.32329 -22.45295 1.000 25.77423  ? 1097 THR   B CB   1 
ATOM   2521 O  OG1  . THR   B 2 45  ? -9.30250  -19.87121 -22.61294 1.000 26.72538  ? 1097 THR   B OG1  1 
ATOM   2522 C  CG2  . THR   B 2 45  ? -7.42644  -19.85822 -21.10100 1.000 23.15974  ? 1097 THR   B CG2  1 
ATOM   2523 N  N    . CYS   B 2 46  ? -8.32261  -19.93752 -25.71897 1.000 21.42486  ? 1098 CYS   B N    1 
ATOM   2524 C  CA   . CYS   B 2 46  ? -8.73571  -20.66559 -26.90489 1.000 23.73284  ? 1098 CYS   B CA   1 
ATOM   2525 C  C    . CYS   B 2 46  ? -9.26367  -19.65263 -27.90295 1.000 27.42887  ? 1098 CYS   B C    1 
ATOM   2526 O  O    . CYS   B 2 46  ? -9.57157  -18.51458 -27.54303 1.000 27.16948  ? 1098 CYS   B O    1 
ATOM   2527 C  CB   . CYS   B 2 46  ? -9.77877  -21.74249 -26.57877 1.000 25.68801  ? 1098 CYS   B CB   1 
ATOM   2528 S  SG   . CYS   B 2 46  ? -11.19769 -21.05931 -25.66577 1.000 28.89287  ? 1098 CYS   B SG   1 
ATOM   2529 N  N    . CYS   B 2 47  ? -9.34875  -20.06372 -29.16792 1.000 26.99813  ? 1099 CYS   B N    1 
ATOM   2530 C  CA   . CYS   B 2 47  ? -9.73571  -19.10978 -30.19998 1.000 25.37132  ? 1099 CYS   B CA   1 
ATOM   2531 C  C    . CYS   B 2 47  ? -10.42881 -19.81682 -31.35290 1.000 24.75805  ? 1099 CYS   B C    1 
ATOM   2532 O  O    . CYS   B 2 47  ? -10.25490 -21.01685 -31.57481 1.000 28.12395  ? 1099 CYS   B O    1 
ATOM   2533 C  CB   . CYS   B 2 47  ? -8.52168  -18.32891 -30.72609 1.000 25.37272  ? 1099 CYS   B CB   1 
ATOM   2534 S  SG   . CYS   B 2 47  ? -7.17677  -19.41804 -31.19505 1.000 32.11248  ? 1099 CYS   B SG   1 
ATOM   2535 N  N    . ALA   B 2 48  ? -11.22677 -19.03582 -32.07493 1.000 23.81846  ? 1100 ALA   B N    1 
ATOM   2536 C  CA   . ALA   B 2 48  ? -11.78885 -19.38588 -33.37289 1.000 28.07294  ? 1100 ALA   B CA   1 
ATOM   2537 C  C    . ALA   B 2 48  ? -12.08178 -18.07691 -34.08798 1.000 31.30005  ? 1100 ALA   B C    1 
ATOM   2538 O  O    . ALA   B 2 48  ? -12.48668 -17.10183 -33.44404 1.000 28.59413  ? 1100 ALA   B O    1 
ATOM   2539 C  CB   . ALA   B 2 48  ? -13.07790 -20.20878 -33.25077 1.000 21.59000  ? 1100 ALA   B CB   1 
ATOM   2540 N  N    . PHE   B 2 49  ? -11.87682 -18.04303 -35.40199 1.000 24.14270  ? 1101 PHE   B N    1 
ATOM   2541 C  CA   . PHE   B 2 49  ? -12.29776 -16.85606 -36.13407 1.000 30.13135  ? 1101 PHE   B CA   1 
ATOM   2542 C  C    . PHE   B 2 49  ? -13.80975 -16.74895 -36.11302 1.000 30.32395  ? 1101 PHE   B C    1 
ATOM   2543 O  O    . PHE   B 2 49  ? -14.52583 -17.75390 -36.14492 1.000 30.49953  ? 1101 PHE   B O    1 
ATOM   2544 C  CB   . PHE   B 2 49  ? -11.80182 -16.88721 -37.58408 1.000 25.02384  ? 1101 PHE   B CB   1 
ATOM   2545 C  CG   . PHE   B 2 49  ? -10.33280 -16.66233 -37.70115 1.000 27.58941  ? 1101 PHE   B CG   1 
ATOM   2546 C  CD1  . PHE   B 2 49  ? -9.45688  -17.72038 -37.59810 1.000 26.61200  ? 1101 PHE   B CD1  1 
ATOM   2547 C  CD2  . PHE   B 2 49  ? -9.83372  -15.38538 -37.85727 1.000 31.57202  ? 1101 PHE   B CD2  1 
ATOM   2548 C  CE1  . PHE   B 2 49  ? -8.09187  -17.52449 -37.69717 1.000 29.49342  ? 1101 PHE   B CE1  1 
ATOM   2549 C  CE2  . PHE   B 2 49  ? -8.46471  -15.17348 -37.96334 1.000 31.39911  ? 1101 PHE   B CE2  1 
ATOM   2550 C  CZ   . PHE   B 2 49  ? -7.59878  -16.24254 -37.87728 1.000 29.81800  ? 1101 PHE   B CZ   1 
ATOM   2551 N  N    . SER   B 2 50  ? -14.30266 -15.52591 -36.07510 1.000 35.74932  ? 1102 SER   B N    1 
ATOM   2552 C  CA   . SER   B 2 50  ? -15.73866 -15.37882 -36.24406 1.000 45.62359  ? 1102 SER   B CA   1 
ATOM   2553 C  C    . SER   B 2 50  ? -16.08370 -15.26791 -37.72606 1.000 42.70745  ? 1102 SER   B C    1 
ATOM   2554 O  O    . SER   B 2 50  ? -15.21273 -15.17604 -38.59510 1.000 43.13921  ? 1102 SER   B O    1 
ATOM   2555 C  CB   . SER   B 2 50  ? -16.26154 -14.16472 -35.47914 1.000 44.55238  ? 1102 SER   B CB   1 
ATOM   2556 O  OG   . SER   B 2 50  ? -15.82248 -12.97880 -36.09125 1.000 44.45468  ? 1102 SER   B OG   1 
ATOM   2557 N  N    . ALA   B 2 51  ? -17.38572 -15.30284 -38.00701 1.000 45.83738  ? 1103 ALA   B N    1 
ATOM   2558 C  CA   . ALA   B 2 51  ? -17.86075 -15.10591 -39.37501 1.000 48.94066  ? 1103 ALA   B CA   1 
ATOM   2559 C  C    . ALA   B 2 51  ? -17.38467 -13.76499 -39.93213 1.000 54.75105  ? 1103 ALA   B C    1 
ATOM   2560 O  O    . ALA   B 2 51  ? -16.84171 -13.69612 -41.04016 1.000 58.76679  ? 1103 ALA   B O    1 
ATOM   2561 C  CB   . ALA   B 2 51  ? -19.38776 -15.20081 -39.41095 1.000 45.39621  ? 1103 ALA   B CB   1 
ATOM   2562 N  N    . ARG   B 2 52  ? -17.50257 -12.74592 -39.07521 1.000 54.96443  ? 1104 ARG   B N    1 
ATOM   2563 C  CA   . ARG   B 2 52  ? -17.04148 -11.38498 -39.42433 1.000 57.39854  ? 1104 ARG   B CA   1 
ATOM   2564 C  C    . ARG   B 2 52  ? -15.51949 -11.40109 -39.47938 1.000 55.38598  ? 1104 ARG   B C    1 
ATOM   2565 O  O    . ARG   B 2 52  ? -14.85245 -11.44006 -38.43041 1.000 53.72103  ? 1104 ARG   B O    1 
ATOM   2566 C  CB   . ARG   B 2 52  ? -17.50137 -10.37086 -38.37540 1.000 58.50745  ? 1104 ARG   B CB   1 
ATOM   2567 C  CG   . ARG   B 2 52  ? -17.29628 -8.91191  -38.75652 1.000 65.36180  ? 1104 ARG   B CG   1 
ATOM   2568 C  CD   . ARG   B 2 52  ? -17.90218 -7.96578  -37.72957 1.000 68.38207  ? 1104 ARG   B CD   1 
ATOM   2569 N  NE   . ARG   B 2 52  ? -17.77309 -6.56082  -38.13569 1.000 79.33985  ? 1104 ARG   B NE   1 
ATOM   2570 C  CZ   . ARG   B 2 52  ? -17.53899 -5.54378  -37.31578 1.000 76.30334  ? 1104 ARG   B CZ   1 
ATOM   2571 N  NH1  . ARG   B 2 52  ? -17.86495 -5.62865  -36.03776 1.000 70.24986  ? 1104 ARG   B NH1  1 
ATOM   2572 N  NH2  . ARG   B 2 52  ? -16.97092 -4.44385  -37.77688 1.000 74.18022  ? 1104 ARG   B NH2  1 
ATOM   2573 N  N    . GLU   B 2 53  ? -15.00453 -11.38023 -40.69040 1.000 61.27912  ? 1105 GLU   B N    1 
ATOM   2574 C  CA   . GLU   B 2 53  ? -13.53454 -11.44134 -40.84945 1.000 69.23563  ? 1105 GLU   B CA   1 
ATOM   2575 C  C    . GLU   B 2 53  ? -12.10150 -11.14741 -40.40453 1.000 68.70550  ? 1105 GLU   B C    1 
ATOM   2576 O  O    . GLU   B 2 53  ? -11.21557 -11.98350 -40.66949 1.000 67.52261  ? 1105 GLU   B O    1 
ATOM   2577 C  CB   . GLU   B 2 53  ? -13.26758 -11.27548 -42.34447 1.000 71.80825  ? 1105 GLU   B CB   1 
ATOM   2578 C  CG   . GLU   B 2 53  ? -13.64350 -9.89950  -42.88057 1.000 66.22886  ? 1105 GLU   B CG   1 
ATOM   2579 C  CD   . GLU   B 2 53  ? -13.11653 -9.66965  -44.28161 1.000 83.17624  ? 1105 GLU   B CD   1 
ATOM   2580 O  OE1  . GLU   B 2 53  ? -13.20963 -10.60870 -45.10053 1.000 87.82364  ? 1105 GLU   B OE1  1 
ATOM   2581 O  OE2  . GLU   B 2 53  ? -12.61146 -8.56270  -44.55471 1.000 89.30417  ? 1105 GLU   B OE2  1 
ATOM   2582 N  N    . ARG   B 2 54  ? -11.92140 -10.03337 -39.69862 1.000 56.19905  ? 1106 ARG   B N    1 
ATOM   2583 C  CA   . ARG   B 2 54  ? -10.61735 -9.58243  -39.23270 1.000 53.61495  ? 1106 ARG   B CA   1 
ATOM   2584 C  C    . ARG   B 2 54  ? -10.78830 -9.75830  -37.71768 1.000 43.11702  ? 1106 ARG   B C    1 
ATOM   2585 O  O    . ARG   B 2 54  ? -9.94124  -9.26830  -36.95875 1.000 36.27353  ? 1106 ARG   B O    1 
ATOM   2586 C  CB   . ARG   B 2 54  ? -10.84925 -8.10244  -39.60281 1.000 56.29328  ? 1106 ARG   B CB   1 
ATOM   2587 C  CG   . ARG   B 2 54  ? -10.66728 -7.79257  -41.10284 1.000 66.84140  ? 1106 ARG   B CG   1 
ATOM   2588 C  CD   . ARG   B 2 54  ? -10.63219 -6.28460  -41.41696 1.000 62.72453  ? 1106 ARG   B CD   1 
ATOM   2589 N  NE   . ARG   B 2 54  ? -9.46212  -5.62164  -40.84506 1.000 67.91682  ? 1106 ARG   B NE   1 
ATOM   2590 C  CZ   . ARG   B 2 54  ? -9.51001  -4.60957  -39.98314 1.000 67.42961  ? 1106 ARG   B CZ   1 
ATOM   2591 N  NH1  . ARG   B 2 54  ? -10.66196 -4.07145  -39.61014 1.000 61.37249  ? 1106 ARG   B NH1  1 
ATOM   2592 N  NH2  . ARG   B 2 54  ? -8.37296  -4.12361  -39.48422 1.000 59.78220  ? 1106 ARG   B NH2  1 
ATOM   2593 N  N    . PHE   B 2 55  ? -11.83234 -10.48819 -37.31159 1.000 40.02268  ? 1107 PHE   B N    1 
ATOM   2594 C  CA   . PHE   B 2 55  ? -12.14630 -10.63205 -35.86457 1.000 37.95316  ? 1107 PHE   B CA   1 
ATOM   2595 C  C    . PHE   B 2 55  ? -12.02039 -12.07202 -35.39346 1.000 36.91275  ? 1107 PHE   B C    1 
ATOM   2596 O  O    . PHE   B 2 55  ? -12.50048 -12.99904 -36.06137 1.000 34.91678  ? 1107 PHE   B O    1 
ATOM   2597 C  CB   . PHE   B 2 55  ? -13.52725 -10.06093 -35.54156 1.000 40.28720  ? 1107 PHE   B CB   1 
ATOM   2598 C  CG   . PHE   B 2 55  ? -13.63915 -8.58394  -35.87767 1.000 41.60022  ? 1107 PHE   B CG   1 
ATOM   2599 C  CD1  . PHE   B 2 55  ? -12.98406 -7.63293  -35.11177 1.000 43.13419  ? 1107 PHE   B CD1  1 
ATOM   2600 C  CD2  . PHE   B 2 55  ? -14.37516 -8.15898  -36.97468 1.000 51.49261  ? 1107 PHE   B CD2  1 
ATOM   2601 C  CE1  . PHE   B 2 55  ? -13.07497 -6.28895  -35.42888 1.000 48.71326  ? 1107 PHE   B CE1  1 
ATOM   2602 C  CE2  . PHE   B 2 55  ? -14.46408 -6.81300  -37.28279 1.000 54.91746  ? 1107 PHE   B CE2  1 
ATOM   2603 C  CZ   . PHE   B 2 55  ? -13.81498 -5.88298  -36.50988 1.000 49.42544  ? 1107 PHE   B CZ   1 
ATOM   2604 N  N    . LEU   B 2 56  ? -11.38136 -12.23798 -34.23847 1.000 33.33792  ? 1108 LEU   B N    1 
ATOM   2605 C  CA   . LEU   B 2 56  ? -11.19144 -13.57494 -33.65837 1.000 29.47736  ? 1108 LEU   B CA   1 
ATOM   2606 C  C    . LEU   B 2 56  ? -11.86539 -13.60379 -32.29134 1.000 29.55827  ? 1108 LEU   B C    1 
ATOM   2607 O  O    . LEU   B 2 56  ? -11.73529 -12.63374 -31.53742 1.000 28.96945  ? 1108 LEU   B O    1 
ATOM   2608 C  CB   . LEU   B 2 56  ? -9.69845  -13.83004 -33.51940 1.000 31.22866  ? 1108 LEU   B CB   1 
ATOM   2609 C  CG   . LEU   B 2 56  ? -9.27753  -15.19503 -32.97531 1.000 28.64788  ? 1108 LEU   B CG   1 
ATOM   2610 C  CD1  . LEU   B 2 56  ? -9.17164  -16.17313 -34.12223 1.000 27.52167  ? 1108 LEU   B CD1  1 
ATOM   2611 C  CD2  . LEU   B 2 56  ? -7.93549  -15.04707 -32.29837 1.000 27.96518  ? 1108 LEU   B CD2  1 
ATOM   2612 N  N    . MET   B 2 57  ? -12.58646 -14.67172 -32.02723 1.000 28.46538  ? 1109 MET   B N    1 
ATOM   2613 C  CA   . MET   B 2 57  ? -13.18342 -14.86357 -30.71019 1.000 31.40130  ? 1109 MET   B CA   1 
ATOM   2614 C  C    . MET   B 2 57  ? -12.18945 -15.60157 -29.82917 1.000 26.76941  ? 1109 MET   B C    1 
ATOM   2615 O  O    . MET   B 2 57  ? -11.60953 -16.60365 -30.25011 1.000 28.65536  ? 1109 MET   B O    1 
ATOM   2616 C  CB   . MET   B 2 57  ? -14.48548 -15.64848 -30.80509 1.000 30.15712  ? 1109 MET   B CB   1 
ATOM   2617 C  CG   . MET   B 2 57  ? -15.43948 -15.08449 -31.82410 1.000 38.67147  ? 1109 MET   B CG   1 
ATOM   2618 S  SD   . MET   B 2 57  ? -16.72358 -16.28644 -32.27396 1.000 46.11858  ? 1109 MET   B SD   1 
ATOM   2619 C  CE   . MET   B 2 57  ? -17.99551 -15.80425 -31.12195 1.000 44.89819  ? 1109 MET   B CE   1 
ATOM   2620 N  N    . LEU   B 2 58  ? -11.98337 -15.10249 -28.61822 1.000 27.55831  ? 1110 LEU   B N    1 
ATOM   2621 C  CA   . LEU   B 2 58  ? -11.08538 -15.75548 -27.68520 1.000 25.33380  ? 1110 LEU   B CA   1 
ATOM   2622 C  C    . LEU   B 2 58  ? -11.80135 -16.00032 -26.36515 1.000 28.39050  ? 1110 LEU   B C    1 
ATOM   2623 O  O    . LEU   B 2 58  ? -12.50127 -15.12123 -25.85120 1.000 25.07270  ? 1110 LEU   B O    1 
ATOM   2624 C  CB   . LEU   B 2 58  ? -9.81831  -14.93255 -27.43531 1.000 23.10623  ? 1110 LEU   B CB   1 
ATOM   2625 C  CG   . LEU   B 2 58  ? -8.97233  -14.61171 -28.66936 1.000 29.42765  ? 1110 LEU   B CG   1 
ATOM   2626 C  CD1  . LEU   B 2 58  ? -9.23324  -13.15473 -29.11147 1.000 25.39618  ? 1110 LEU   B CD1  1 
ATOM   2627 C  CD2  . LEU   B 2 58  ? -7.49134  -14.85980 -28.40240 1.000 24.67617  ? 1110 LEU   B CD2  1 
ATOM   2628 N  N    . GLY   B 2 59  ? -11.62542 -17.20029 -25.82606 1.000 24.57593  ? 1111 GLY   B N    1 
ATOM   2629 C  CA   . GLY   B 2 59  ? -11.98639 -17.45516 -24.44603 1.000 24.22472  ? 1111 GLY   B CA   1 
ATOM   2630 C  C    . GLY   B 2 59  ? -10.85933 -17.08017 -23.53110 1.000 24.22794  ? 1111 GLY   B C    1 
ATOM   2631 O  O    . GLY   B 2 59  ? -9.71234  -17.03229 -23.97015 1.000 26.02902  ? 1111 GLY   B O    1 
ATOM   2632 N  N    . THR   B 2 60  ? -11.18426 -16.80404 -22.26411 1.000 25.86948  ? 1112 THR   B N    1 
ATOM   2633 C  CA   . THR   B 2 60  ? -10.16020 -16.44804 -21.28918 1.000 26.12865  ? 1112 THR   B CA   1 
ATOM   2634 C  C    . THR   B 2 60  ? -10.27222 -17.30093 -20.03110 1.000 28.48286  ? 1112 THR   B C    1 
ATOM   2635 O  O    . THR   B 2 60  ? -11.27326 -17.98984 -19.78001 1.000 25.37814  ? 1112 THR   B O    1 
ATOM   2636 C  CB   . THR   B 2 60  ? -10.25108 -14.98100 -20.87029 1.000 29.12739  ? 1112 THR   B CB   1 
ATOM   2637 O  OG1  . THR   B 2 60  ? -11.33804 -14.85585 -19.93926 1.000 28.14886  ? 1112 THR   B OG1  1 
ATOM   2638 C  CG2  . THR   B 2 60  ? -10.47106 -14.09008 -22.06435 1.000 21.69243  ? 1112 THR   B CG2  1 
ATOM   2639 N  N    . CYS   B 2 61  ? -9.22118  -17.21594 -19.21115 1.000 25.73252  ? 1113 CYS   B N    1 
ATOM   2640 C  CA   . CYS   B 2 61  ? -9.14820  -17.98685 -17.98209 1.000 29.50543  ? 1113 CYS   B CA   1 
ATOM   2641 C  C    . CYS   B 2 61  ? -10.13512 -17.50770 -16.92509 1.000 24.81729  ? 1113 CYS   B C    1 
ATOM   2642 O  O    . CYS   B 2 61  ? -10.28214 -18.18161 -15.90203 1.000 32.31649  ? 1113 CYS   B O    1 
ATOM   2643 C  CB   . CYS   B 2 61  ? -7.72017  -17.96791 -17.42414 1.000 34.13347  ? 1113 CYS   B CB   1 
ATOM   2644 S  SG   . CYS   B 2 61  ? -7.11904  -16.33892 -16.97229 1.000 38.16976  ? 1113 CYS   B SG   1 
ATOM   2645 N  N    . THR   B 2 62  ? -10.83905 -16.39766 -17.14616 1.000 28.06039  ? 1114 THR   B N    1 
ATOM   2646 C  CA   . THR   B 2 62  ? -11.85698 -15.94452 -16.20716 1.000 29.94082  ? 1114 THR   B CA   1 
ATOM   2647 C  C    . THR   B 2 62  ? -13.27302 -16.20645 -16.71108 1.000 32.65297  ? 1114 THR   B C    1 
ATOM   2648 O  O    . THR   B 2 62  ? -14.22696 -15.62334 -16.18710 1.000 36.21789  ? 1114 THR   B O    1 
ATOM   2649 C  CB   . THR   B 2 62  ? -11.68487 -14.45450 -15.90128 1.000 31.53526  ? 1114 THR   B CB   1 
ATOM   2650 O  OG1  . THR   B 2 62  ? -11.89085 -13.69958 -17.09133 1.000 38.81734  ? 1114 THR   B OG1  1 
ATOM   2651 C  CG2  . THR   B 2 62  ? -10.28983 -14.18056 -15.37435 1.000 35.56611  ? 1114 THR   B CG2  1 
ATOM   2652 N  N    . GLY   B 2 63  ? -13.43212 -17.05852 -17.71301 1.000 27.07322  ? 1115 GLY   B N    1 
ATOM   2653 C  CA   . GLY   B 2 63  ? -14.76416 -17.37746 -18.18594 1.000 23.74778  ? 1115 GLY   B CA   1 
ATOM   2654 C  C    . GLY   B 2 63  ? -15.36512 -16.36449 -19.12900 1.000 28.30807  ? 1115 GLY   B C    1 
ATOM   2655 O  O    . GLY   B 2 63  ? -16.57213 -16.42743 -19.41295 1.000 28.56571  ? 1115 GLY   B O    1 
ATOM   2656 N  N    . GLN   B 2 64  ? -14.56507 -15.44259 -19.63710 1.000 27.95399  ? 1116 GLN   B N    1 
ATOM   2657 C  CA   . GLN   B 2 64  ? -15.04503 -14.42663 -20.54716 1.000 26.83234  ? 1116 GLN   B CA   1 
ATOM   2658 C  C    . GLN   B 2 64  ? -14.81511 -14.82576 -21.99514 1.000 28.36796  ? 1116 GLN   B C    1 
ATOM   2659 O  O    . GLN   B 2 64  ? -13.85417 -15.51986 -22.32412 1.000 26.53620  ? 1116 GLN   B O    1 
ATOM   2660 C  CB   . GLN   B 2 64  ? -14.34692 -13.10466 -20.27529 1.000 36.96411  ? 1116 GLN   B CB   1 
ATOM   2661 C  CG   . GLN   B 2 64  ? -14.50784 -12.63753 -18.85432 1.000 33.70691  ? 1116 GLN   B CG   1 
ATOM   2662 C  CD   . GLN   B 2 64  ? -14.25073 -11.15655 -18.78045 1.000 50.06543  ? 1116 GLN   B CD   1 
ATOM   2663 O  OE1  . GLN   B 2 64  ? -13.10970 -10.71563 -18.77552 1.000 54.15500  ? 1116 GLN   B OE1  1 
ATOM   2664 N  NE2  . GLN   B 2 64  ? -15.31467 -10.36947 -18.76947 1.000 55.89707  ? 1116 GLN   B NE2  1 
ATOM   2665 N  N    . LEU   B 2 65  ? -15.71711 -14.37576 -22.85214 1.000 26.14458  ? 1117 LEU   B N    1 
ATOM   2666 C  CA   . LEU   B 2 65  ? -15.56317 -14.45089 -24.29714 1.000 28.37474  ? 1117 LEU   B CA   1 
ATOM   2667 C  C    . LEU   B 2 65  ? -15.26508 -13.05795 -24.82626 1.000 31.05314  ? 1117 LEU   B C    1 
ATOM   2668 O  O    . LEU   B 2 65  ? -16.00300 -12.11487 -24.53331 1.000 29.29258  ? 1117 LEU   B O    1 
ATOM   2669 C  CB   . LEU   B 2 65  ? -16.82423 -14.98985 -24.97405 1.000 26.16458  ? 1117 LEU   B CB   1 
ATOM   2670 C  CG   . LEU   B 2 65  ? -16.71228 -14.89098 -26.50507 1.000 34.15550  ? 1117 LEU   B CG   1 
ATOM   2671 C  CD1  . LEU   B 2 65  ? -16.06339 -16.13907 -27.07299 1.000 35.64638  ? 1117 LEU   B CD1  1 
ATOM   2672 C  CD2  . LEU   B 2 65  ? -18.05028 -14.62893 -27.13604 1.000 30.93795  ? 1117 LEU   B CD2  1 
ATOM   2673 N  N    . LYS   B 2 66  ? -14.20310 -12.92709 -25.61531 1.000 27.65836  ? 1118 LYS   B N    1 
ATOM   2674 C  CA   . LYS   B 2 66  ? -13.81203 -11.62516 -26.14543 1.000 30.09518  ? 1118 LYS   B CA   1 
ATOM   2675 C  C    . LYS   B 2 66  ? -13.63709 -11.68829 -27.65543 1.000 31.32864  ? 1118 LYS   B C    1 
ATOM   2676 O  O    . LYS   B 2 66  ? -13.24118 -12.71437 -28.21536 1.000 32.26441  ? 1118 LYS   B O    1 
ATOM   2677 C  CB   . LYS   B 2 66  ? -12.54897 -11.11820 -25.47651 1.000 29.03455  ? 1118 LYS   B CB   1 
ATOM   2678 C  CG   . LYS   B 2 66  ? -12.81488 -10.70807 -24.02554 1.000 34.03429  ? 1118 LYS   B CG   1 
ATOM   2679 C  CD   . LYS   B 2 66  ? -11.57982 -10.22810 -23.31262 1.000 37.17143  ? 1118 LYS   B CD   1 
ATOM   2680 C  CE   . LYS   B 2 66  ? -11.95473 -9.48097  -22.04366 1.000 36.06074  ? 1118 LYS   B CE   1 
ATOM   2681 N  NZ   . LYS   B 2 66  ? -10.74667 -9.03000  -21.31674 1.000 43.49016  ? 1118 LYS   B NZ   1 
ATOM   2682 N  N    . LEU   B 2 67  ? -13.99703 -10.58432 -28.30650 1.000 27.86972  ? 1119 LEU   B N    1 
ATOM   2683 C  CA   . LEU   B 2 67  ? -13.82207 -10.39444 -29.73952 1.000 30.21128  ? 1119 LEU   B CA   1 
ATOM   2684 C  C    . LEU   B 2 67  ? -12.68000 -9.40954  -29.93864 1.000 33.43703  ? 1119 LEU   B C    1 
ATOM   2685 O  O    . LEU   B 2 67  ? -12.66490 -8.34749  -29.30673 1.000 31.41501  ? 1119 LEU   B O    1 
ATOM   2686 C  CB   . LEU   B 2 67  ? -15.10705 -9.86640  -30.37952 1.000 27.09888  ? 1119 LEU   B CB   1 
ATOM   2687 C  CG   . LEU   B 2 67  ? -15.94415 -10.85141 -31.19641 1.000 44.11804  ? 1119 LEU   B CG   1 
ATOM   2688 C  CD1  . LEU   B 2 67  ? -15.22322 -11.20856 -32.48841 1.000 38.90336  ? 1119 LEU   B CD1  1 
ATOM   2689 C  CD2  . LEU   B 2 67  ? -16.25921 -12.12332 -30.39230 1.000 45.37467  ? 1119 LEU   B CD2  1 
ATOM   2690 N  N    . TYR   B 2 68  ? -11.71706 -9.77468  -30.77665 1.000 27.00939  ? 1120 TYR   B N    1 
ATOM   2691 C  CA   . TYR   B 2 68  ? -10.53001 -8.97278  -31.01175 1.000 29.93409  ? 1120 TYR   B CA   1 
ATOM   2692 C  C    . TYR   B 2 68  ? -10.32405 -8.80892  -32.50577 1.000 32.41315  ? 1120 TYR   B C    1 
ATOM   2693 O  O    . TYR   B 2 68  ? -10.53715 -9.74596  -33.28169 1.000 27.40061  ? 1120 TYR   B O    1 
ATOM   2694 C  CB   . TYR   B 2 68  ? -9.25803  -9.60383  -30.41675 1.000 29.12450  ? 1120 TYR   B CB   1 
ATOM   2695 C  CG   . TYR   B 2 68  ? -8.97295  -9.16974  -29.00579 1.000 29.62295  ? 1120 TYR   B CG   1 
ATOM   2696 C  CD1  . TYR   B 2 68  ? -9.70095  -9.68460  -27.95073 1.000 27.73957  ? 1120 TYR   B CD1  1 
ATOM   2697 C  CD2  . TYR   B 2 68  ? -7.96987  -8.23179  -28.72190 1.000 30.10819  ? 1120 TYR   B CD2  1 
ATOM   2698 C  CE1  . TYR   B 2 68  ? -9.45888  -9.28951  -26.63677 1.000 29.13776  ? 1120 TYR   B CE1  1 
ATOM   2699 C  CE2  . TYR   B 2 68  ? -7.71380  -7.82470  -27.38695 1.000 29.67770  ? 1120 TYR   B CE2  1 
ATOM   2700 C  CZ   . TYR   B 2 68  ? -8.46980  -8.36256  -26.35788 1.000 29.16094  ? 1120 TYR   B CZ   1 
ATOM   2701 O  OH   . TYR   B 2 68  ? -8.26873  -7.99547  -25.04591 1.000 33.35517  ? 1120 TYR   B OH   1 
ATOM   2702 N  N    . ASN   B 2 69  ? -9.91098  -7.60798  -32.89488 1.000 33.02356  ? 1121 ASN   B N    1 
ATOM   2703 C  CA   . ASN   B 2 69  ? -9.39301  -7.37812  -34.23392 1.000 29.76994  ? 1121 ASN   B CA   1 
ATOM   2704 C  C    . ASN   B 2 69  ? -8.01306  -7.99723  -34.32392 1.000 29.32308  ? 1121 ASN   B C    1 
ATOM   2705 O  O    . ASN   B 2 69  ? -7.09600  -7.56224  -33.61599 1.000 29.25888  ? 1121 ASN   B O    1 
ATOM   2706 C  CB   . ASN   B 2 69  ? -9.31891  -5.88015  -34.52004 1.000 32.06448  ? 1121 ASN   B CB   1 
ATOM   2707 C  CG   . ASN   B 2 69  ? -8.91794  -5.58929  -35.95508 1.000 36.72291  ? 1121 ASN   B CG   1 
ATOM   2708 O  OD1  . ASN   B 2 69  ? -7.81898  -5.95241  -36.39409 1.000 32.24516  ? 1121 ASN   B OD1  1 
ATOM   2709 N  ND2  . ASN   B 2 69  ? -9.81392  -4.94729  -36.69710 1.000 38.35771  ? 1121 ASN   B ND2  1 
ATOM   2710 N  N    . VAL   B 2 70  ? -7.85116  -9.01931  -35.16985 1.000 30.17559  ? 1122 VAL   B N    1 
ATOM   2711 C  CA   . VAL   B 2 70  ? -6.58621  -9.76140  -35.14883 1.000 30.93102  ? 1122 VAL   B CA   1 
ATOM   2712 C  C    . VAL   B 2 70  ? -5.41517  -8.92752  -35.64794 1.000 32.23110  ? 1122 VAL   B C    1 
ATOM   2713 O  O    . VAL   B 2 70  ? -4.26218  -9.23758  -35.31896 1.000 30.13066  ? 1122 VAL   B O    1 
ATOM   2714 C  CB   . VAL   B 2 70  ? -6.67334  -11.06345 -35.96873 1.000 31.00750  ? 1122 VAL   B CB   1 
ATOM   2715 C  CG1  . VAL   B 2 70  ? -7.61538  -12.05833 -35.30161 1.000 31.17254  ? 1122 VAL   B CG1  1 
ATOM   2716 C  CG2  . VAL   B 2 70  ? -7.10637  -10.77254 -37.41973 1.000 29.70320  ? 1122 VAL   B CG2  1 
ATOM   2717 N  N    . PHE   B 2 71  ? -5.66912  -7.88056  -36.44001 1.000 27.04848  ? 1123 PHE   B N    1 
ATOM   2718 C  CA   . PHE   B 2 71  ? -4.57009  -7.10769  -37.02211 1.000 31.78819  ? 1123 PHE   B CA   1 
ATOM   2719 C  C    . PHE   B 2 71  ? -4.10197  -5.96065  -36.12622 1.000 30.43520  ? 1123 PHE   B C    1 
ATOM   2720 O  O    . PHE   B 2 71  ? -2.88795  -5.76773  -35.94728 1.000 33.03171  ? 1123 PHE   B O    1 
ATOM   2721 C  CB   . PHE   B 2 71  ? -4.98210  -6.58677  -38.40514 1.000 31.93784  ? 1123 PHE   B CB   1 
ATOM   2722 C  CG   . PHE   B 2 71  ? -5.31821  -7.69382  -39.37104 1.000 35.48008  ? 1123 PHE   B CG   1 
ATOM   2723 C  CD1  . PHE   B 2 71  ? -4.30829  -8.50294  -39.90501 1.000 38.12729  ? 1123 PHE   B CD1  1 
ATOM   2724 C  CD2  . PHE   B 2 71  ? -6.63925  -7.96375  -39.70597 1.000 36.29315  ? 1123 PHE   B CD2  1 
ATOM   2725 C  CE1  . PHE   B 2 71  ? -4.61640  -9.55098  -40.77792 1.000 31.84041  ? 1123 PHE   B CE1  1 
ATOM   2726 C  CE2  . PHE   B 2 71  ? -6.95635  -9.00280  -40.57588 1.000 37.24041  ? 1123 PHE   B CE2  1 
ATOM   2727 C  CZ   . PHE   B 2 71  ? -5.94743  -9.78791  -41.11885 1.000 35.82946  ? 1123 PHE   B CZ   1 
ATOM   2728 N  N    . SER   B 2 72  ? -5.03090  -5.21154  -35.53825 1.000 32.21775  ? 1124 SER   B N    1 
ATOM   2729 C  CA   . SER   B 2 72  ? -4.65079  -4.14949  -34.61035 1.000 31.26759  ? 1124 SER   B CA   1 
ATOM   2730 C  C    . SER   B 2 72  ? -4.43877  -4.64540  -33.19531 1.000 35.54104  ? 1124 SER   B C    1 
ATOM   2731 O  O    . SER   B 2 72  ? -3.67870  -4.03139  -32.44039 1.000 34.29413  ? 1124 SER   B O    1 
ATOM   2732 C  CB   . SER   B 2 72  ? -5.72671  -3.06941  -34.57539 1.000 29.10329  ? 1124 SER   B CB   1 
ATOM   2733 O  OG   . SER   B 2 72  ? -6.92073  -3.58228  -34.01431 1.000 37.58526  ? 1124 SER   B OG   1 
ATOM   2734 N  N    . GLY   B 2 73  ? -5.10384  -5.73332  -32.80920 1.000 31.36641  ? 1125 GLY   B N    1 
ATOM   2735 C  CA   . GLY   B 2 73  ? -5.09482  -6.16221  -31.42817 1.000 30.23258  ? 1125 GLY   B CA   1 
ATOM   2736 C  C    . GLY   B 2 73  ? -6.12874  -5.48707  -30.56419 1.000 29.69427  ? 1125 GLY   B C    1 
ATOM   2737 O  O    . GLY   B 2 73  ? -6.05671  -5.60397  -29.33818 1.000 32.17746  ? 1125 GLY   B O    1 
ATOM   2738 N  N    . GLN   B 2 74  ? -7.07771  -4.78405  -31.16721 1.000 27.53578  ? 1126 GLN   B N    1 
ATOM   2739 C  CA   . GLN   B 2 74  ? -8.10563  -4.06691  -30.43323 1.000 31.23541  ? 1126 GLN   B CA   1 
ATOM   2740 C  C    . GLN   B 2 74  ? -9.16868  -5.02480  -29.91712 1.000 32.09664  ? 1126 GLN   B C    1 
ATOM   2741 O  O    . GLN   B 2 74  ? -9.78177  -5.76081  -30.69804 1.000 32.16858  ? 1126 GLN   B O    1 
ATOM   2742 C  CB   . GLN   B 2 74  ? -8.75959  -3.02994  -31.35029 1.000 33.29886  ? 1126 GLN   B CB   1 
ATOM   2743 C  CG   . GLN   B 2 74  ? -9.89151  -2.27180  -30.70131 1.000 36.67362  ? 1126 GLN   B CG   1 
ATOM   2744 C  CD   . GLN   B 2 74  ? -9.39640  -1.29676  -29.64540 1.000 37.58826  ? 1126 GLN   B CD   1 
ATOM   2745 O  OE1  . GLN   B 2 74  ? -8.50836  -0.48784  -29.89950 1.000 43.87434  ? 1126 GLN   B OE1  1 
ATOM   2746 N  NE2  . GLN   B 2 74  ? -9.95837  -1.38462  -28.44638 1.000 40.96502  ? 1126 GLN   B NE2  1 
ATOM   2747 N  N    . GLU   B 2 75  ? -9.41463  -4.98767  -28.61511 1.000 31.41466  ? 1127 GLU   B N    1 
ATOM   2748 C  CA   . GLU   B 2 75  ? -10.56966 -5.67155  -28.05201 1.000 34.15872  ? 1127 GLU   B CA   1 
ATOM   2749 C  C    . GLU   B 2 75  ? -11.85263 -4.98349  -28.51402 1.000 32.01101  ? 1127 GLU   B C    1 
ATOM   2750 O  O    . GLU   B 2 75  ? -12.01154 -3.77847  -28.34311 1.000 34.16170  ? 1127 GLU   B O    1 
ATOM   2751 C  CB   . GLU   B 2 75  ? -10.48361 -5.69143  -26.53102 1.000 32.77665  ? 1127 GLU   B CB   1 
ATOM   2752 C  CG   . GLU   B 2 75  ? -11.63465 -6.45930  -25.92691 1.000 33.56597  ? 1127 GLU   B CG   1 
ATOM   2753 C  CD   . GLU   B 2 75  ? -11.50760 -6.63019  -24.44191 1.000 29.93722  ? 1127 GLU   B CD   1 
ATOM   2754 O  OE1  . GLU   B 2 75  ? -10.45362 -7.12323  -23.98290 1.000 34.28488  ? 1127 GLU   B OE1  1 
ATOM   2755 O  OE2  . GLU   B 2 75  ? -12.47555 -6.27507  -23.73590 1.000 38.02529  ? 1127 GLU   B OE2  1 
ATOM   2756 N  N    . GLU   B 2 76  ? -12.75771 -5.73947  -29.12193 1.000 34.38820  ? 1128 GLU   B N    1 
ATOM   2757 C  CA   . GLU   B 2 76  ? -13.97769 -5.18543  -29.69393 1.000 29.42250  ? 1128 GLU   B CA   1 
ATOM   2758 C  C    . GLU   B 2 76  ? -15.21268 -5.44427  -28.86087 1.000 33.71584  ? 1128 GLU   B C    1 
ATOM   2759 O  O    . GLU   B 2 76  ? -16.19463 -4.71721  -28.99489 1.000 38.86106  ? 1128 GLU   B O    1 
ATOM   2760 C  CB   . GLU   B 2 76  ? -14.23478 -5.76052  -31.08888 1.000 35.58288  ? 1128 GLU   B CB   1 
ATOM   2761 C  CG   . GLU   B 2 76  ? -13.26578 -5.26668  -32.16795 1.000 43.84190  ? 1128 GLU   B CG   1 
ATOM   2762 C  CD   . GLU   B 2 76  ? -13.38668 -3.77869  -32.40706 1.000 47.75333  ? 1128 GLU   B CD   1 
ATOM   2763 O  OE1  . GLU   B 2 76  ? -14.53165 -3.27161  -32.46806 1.000 50.69514  ? 1128 GLU   B OE1  1 
ATOM   2764 O  OE2  . GLU   B 2 76  ? -12.32964 -3.11977  -32.51915 1.000 52.64963  ? 1128 GLU   B OE2  1 
ATOM   2765 N  N    . ALA   B 2 77  ? -15.21972 -6.49421  -28.05278 1.000 32.05230  ? 1129 ALA   B N    1 
ATOM   2766 C  CA   . ALA   B 2 77  ? -16.38172 -6.82606  -27.24472 1.000 35.44817  ? 1129 ALA   B CA   1 
ATOM   2767 C  C    . ALA   B 2 77  ? -15.92575 -7.82701  -26.19865 1.000 34.01896  ? 1129 ALA   B C    1 
ATOM   2768 O  O    . ALA   B 2 77  ? -14.88781 -8.47910  -26.35664 1.000 28.61166  ? 1129 ALA   B O    1 
ATOM   2769 C  CB   . ALA   B 2 77  ? -17.52979 -7.39405  -28.08663 1.000 35.29344  ? 1129 ALA   B CB   1 
ATOM   2770 N  N    . SER   B 2 78  ? -16.71272 -7.92587  -25.13262 1.000 35.46432  ? 1130 SER   B N    1 
ATOM   2771 C  CA   . SER   B 2 78  ? -16.40675 -8.79480  -24.00456 1.000 34.12615  ? 1130 SER   B CA   1 
ATOM   2772 C  C    . SER   B 2 78  ? -17.71676 -9.23566  -23.38048 1.000 36.60726  ? 1130 SER   B C    1 
ATOM   2773 O  O    . SER   B 2 78  ? -18.59469 -8.40458  -23.14851 1.000 35.11483  ? 1130 SER   B O    1 
ATOM   2774 C  CB   . SER   B 2 78  ? -15.55166 -8.07378  -22.96565 1.000 34.12381  ? 1130 SER   B CB   1 
ATOM   2775 O  OG   . SER   B 2 78  ? -15.28468 -8.92072  -21.86659 1.000 37.87438  ? 1130 SER   B OG   1 
ATOM   2776 N  N    . TYR   B 2 79  ? -17.85184 -10.53363 -23.13537 1.000 32.56516  ? 1131 TYR   B N    1 
ATOM   2777 C  CA   . TYR   B 2 79  ? -19.04186 -11.10650 -22.52928 1.000 32.24725  ? 1131 TYR   B CA   1 
ATOM   2778 C  C    . TYR   B 2 79  ? -18.60089 -12.07444 -21.45222 1.000 29.41323  ? 1131 TYR   B C    1 
ATOM   2779 O  O    . TYR   B 2 79  ? -17.60395 -12.78453 -21.61820 1.000 30.61767  ? 1131 TYR   B O    1 
ATOM   2780 C  CB   . TYR   B 2 79  ? -19.91095 -11.83752 -23.55819 1.000 29.74364  ? 1131 TYR   B CB   1 
ATOM   2781 C  CG   . TYR   B 2 79  ? -20.12894 -11.06460 -24.83725 1.000 40.57667  ? 1131 TYR   B CG   1 
ATOM   2782 C  CD1  . TYR   B 2 79  ? -21.19188 -10.16953 -24.95828 1.000 42.31022  ? 1131 TYR   B CD1  1 
ATOM   2783 C  CD2  . TYR   B 2 79  ? -19.26499 -11.21975 -25.93027 1.000 42.25513  ? 1131 TYR   B CD2  1 
ATOM   2784 C  CE1  . TYR   B 2 79  ? -21.39687 -9.44861  -26.13533 1.000 42.23907  ? 1131 TYR   B CE1  1 
ATOM   2785 C  CE2  . TYR   B 2 79  ? -19.46698 -10.50883 -27.11331 1.000 39.70050  ? 1131 TYR   B CE2  1 
ATOM   2786 C  CZ   . TYR   B 2 79  ? -20.53592 -9.62176  -27.20435 1.000 43.10732  ? 1131 TYR   B CZ   1 
ATOM   2787 O  OH   . TYR   B 2 79  ? -20.75791 -8.90983  -28.36639 1.000 50.32914  ? 1131 TYR   B OH   1 
ATOM   2788 N  N    . ASN   B 2 80  ? -19.33385 -12.09930 -20.34319 1.000 31.00155  ? 1132 ASN   B N    1 
ATOM   2789 C  CA   . ASN   B 2 80  ? -19.07789 -13.07424 -19.29513 1.000 37.84777  ? 1132 ASN   B CA   1 
ATOM   2790 C  C    . ASN   B 2 80  ? -19.91199 -14.30920 -19.60000 1.000 37.57167  ? 1132 ASN   B C    1 
ATOM   2791 O  O    . ASN   B 2 80  ? -21.14698 -14.23412 -19.64896 1.000 43.17192  ? 1132 ASN   B O    1 
ATOM   2792 C  CB   . ASN   B 2 80  ? -19.40080 -12.53110 -17.90416 1.000 37.15146  ? 1132 ASN   B CB   1 
ATOM   2793 C  CG   . ASN   B 2 80  ? -18.95783 -13.49605 -16.78310 1.000 51.14137  ? 1132 ASN   B CG   1 
ATOM   2794 O  OD1  . ASN   B 2 80  ? -17.79286 -13.92313 -16.72410 1.000 45.36759  ? 1132 ASN   B OD1  1 
ATOM   2795 N  ND2  . ASN   B 2 80  ? -19.90783 -13.87891 -15.92003 1.000 58.32993  ? 1132 ASN   B ND2  1 
ATOM   2796 N  N    . CYS   B 2 81  ? -19.23908 -15.43027 -19.84793 1.000 32.36445  ? 1133 CYS   B N    1 
ATOM   2797 C  CA   . CYS   B 2 81  ? -19.92018 -16.66025 -20.23181 1.000 27.55704  ? 1133 CYS   B CA   1 
ATOM   2798 C  C    . CYS   B 2 81  ? -19.96222 -17.71116 -19.13773 1.000 24.42368  ? 1133 CYS   B C    1 
ATOM   2799 O  O    . CYS   B 2 81  ? -20.97826 -18.37208 -18.98064 1.000 26.72597  ? 1133 CYS   B O    1 
ATOM   2800 C  CB   . CYS   B 2 81  ? -19.26327 -17.25940 -21.48379 1.000 27.16171  ? 1133 CYS   B CB   1 
ATOM   2801 S  SG   . CYS   B 2 81  ? -19.60025 -16.26849 -22.94685 1.000 27.89826  ? 1133 CYS   B SG   1 
ATOM   2802 N  N    . HIS   B 2 82  ? -18.88521 -17.91318 -18.39775 1.000 28.12226  ? 1134 HIS   B N    1 
ATOM   2803 C  CA   . HIS   B 2 82  ? -18.83825 -18.98311 -17.41467 1.000 26.26444  ? 1134 HIS   B CA   1 
ATOM   2804 C  C    . HIS   B 2 82  ? -18.14417 -18.46606 -16.16573 1.000 28.34172  ? 1134 HIS   B C    1 
ATOM   2805 O  O    . HIS   B 2 82  ? -17.43609 -17.46211 -16.19884 1.000 28.77003  ? 1134 HIS   B O    1 
ATOM   2806 C  CB   . HIS   B 2 82  ? -18.09036 -20.22720 -17.92559 1.000 23.94382  ? 1134 HIS   B CB   1 
ATOM   2807 C  CG   . HIS   B 2 82  ? -18.75945 -20.91124 -19.08052 1.000 22.65571  ? 1134 HIS   B CG   1 
ATOM   2808 N  ND1  . HIS   B 2 82  ? -19.70751 -21.89716 -18.91240 1.000 25.04423  ? 1134 HIS   B ND1  1 
ATOM   2809 C  CD2  . HIS   B 2 82  ? -18.60248 -20.76836 -20.41853 1.000 23.09515  ? 1134 HIS   B CD2  1 
ATOM   2810 C  CE1  . HIS   B 2 82  ? -20.12058 -22.32323 -20.09536 1.000 24.02078  ? 1134 HIS   B CE1  1 
ATOM   2811 N  NE2  . HIS   B 2 82  ? -19.45257 -21.66635 -21.02743 1.000 23.24211  ? 1134 HIS   B NE2  1 
ATOM   2812 N  N    . ASN   B 2 83  ? -18.34918 -19.18996 -15.06567 1.000 24.79467  ? 1135 ASN   B N    1 
ATOM   2813 C  CA   . ASN   B 2 83  ? -17.70911 -18.91890 -13.79271 1.000 27.75721  ? 1135 ASN   B CA   1 
ATOM   2814 C  C    . ASN   B 2 83  ? -16.42516 -19.70698 -13.61169 1.000 29.03962  ? 1135 ASN   B C    1 
ATOM   2815 O  O    . ASN   B 2 83  ? -16.02614 -19.95392 -12.46869 1.000 27.73751  ? 1135 ASN   B O    1 
ATOM   2816 C  CB   . ASN   B 2 83  ? -18.67410 -19.23074 -12.64365 1.000 28.48604  ? 1135 ASN   B CB   1 
ATOM   2817 C  CG   . ASN   B 2 83  ? -19.85102 -18.27065 -12.59669 1.000 32.05642  ? 1135 ASN   B CG   1 
ATOM   2818 O  OD1  . ASN   B 2 83  ? -19.72295 -17.11469 -12.96078 1.000 31.61497  ? 1135 ASN   B OD1  1 
ATOM   2819 N  ND2  . ASN   B 2 83  ? -20.99604 -18.74453 -12.12161 1.000 34.06090  ? 1135 ASN   B ND2  1 
ATOM   2820 N  N    . SER   B 2 84  ? -15.81024 -20.17011 -14.70368 1.000 23.87327  ? 1136 SER   B N    1 
ATOM   2821 C  CA   . SER   B 2 84  ? -14.47828 -20.75420 -14.64968 1.000 26.07164  ? 1136 SER   B CA   1 
ATOM   2822 C  C    . SER   B 2 84  ? -13.85331 -20.57236 -16.01972 1.000 25.57269  ? 1136 SER   B C    1 
ATOM   2823 O  O    . SER   B 2 84  ? -14.48731 -20.06338 -16.94574 1.000 26.32974  ? 1136 SER   B O    1 
ATOM   2824 C  CB   . SER   B 2 84  ? -14.50637 -22.22817 -14.20256 1.000 27.03008  ? 1136 SER   B CB   1 
ATOM   2825 O  OG   . SER   B 2 84  ? -15.33745 -23.00417 -15.05147 1.000 22.18547  ? 1136 SER   B OG   1 
ATOM   2826 N  N    . ALA   B 2 85  ? -12.60235 -20.99446 -16.15573 1.000 21.48689  ? 1137 ALA   B N    1 
ATOM   2827 C  CA   . ALA   B 2 85  ? -11.87237 -20.69961 -17.38478 1.000 25.38530  ? 1137 ALA   B CA   1 
ATOM   2828 C  C    . ALA   B 2 85  ? -12.50846 -21.38666 -18.59270 1.000 27.16380  ? 1137 ALA   B C    1 
ATOM   2829 O  O    . ALA   B 2 85  ? -12.93355 -22.54662 -18.52859 1.000 23.98532  ? 1137 ALA   B O    1 
ATOM   2830 C  CB   . ALA   B 2 85  ? -10.41440 -21.13270 -17.25280 1.000 21.90411  ? 1137 ALA   B CB   1 
ATOM   2831 N  N    . ILE   B 2 86  ? -12.58445 -20.65574 -19.70276 1.000 24.05964  ? 1138 ILE   B N    1 
ATOM   2832 C  CA   A ILE   B 2 86  ? -13.02954 -21.25981 -20.94869 0.396 25.51726  ? 1138 ILE   B CA   1 
ATOM   2833 C  CA   B ILE   B 2 86  ? -13.02854 -21.25681 -20.95169 0.604 25.62760  ? 1138 ILE   B CA   1 
ATOM   2834 C  C    . ILE   B 2 86  ? -11.95062 -22.20892 -21.43966 1.000 25.87311  ? 1138 ILE   B C    1 
ATOM   2835 O  O    . ILE   B 2 86  ? -10.76660 -21.85501 -21.48273 1.000 25.02154  ? 1138 ILE   B O    1 
ATOM   2836 C  CB   A ILE   B 2 86  ? -13.34550 -20.18287 -21.99377 0.396 26.95371  ? 1138 ILE   B CB   1 
ATOM   2837 C  CB   B ILE   B 2 86  ? -13.32950 -20.17787 -22.00077 0.604 27.07126  ? 1138 ILE   B CB   1 
ATOM   2838 C  CG1  A ILE   B 2 86  ? -14.49142 -19.29275 -21.51180 0.396 27.16401  ? 1138 ILE   B CG1  1 
ATOM   2839 C  CG1  B ILE   B 2 86  ? -14.31540 -19.14375 -21.44981 0.604 27.16499  ? 1138 ILE   B CG1  1 
ATOM   2840 C  CG2  A ILE   B 2 86  ? -13.68159 -20.82395 -23.33370 0.396 25.20702  ? 1138 ILE   B CG2  1 
ATOM   2841 C  CG2  B ILE   B 2 86  ? -13.87259 -20.81493 -23.27570 0.604 25.16610  ? 1138 ILE   B CG2  1 
ATOM   2842 C  CD1  A ILE   B 2 86  ? -14.92038 -18.25179 -22.51986 0.396 25.26461  ? 1138 ILE   B CD1  1 
ATOM   2843 C  CD1  B ILE   B 2 86  ? -15.76544 -19.61165 -21.42273 0.604 25.24687  ? 1138 ILE   B CD1  1 
ATOM   2844 N  N    . THR   B 2 87  ? -12.34573 -23.43392 -21.77955 1.000 26.47712  ? 1139 THR   B N    1 
ATOM   2845 C  CA   . THR   B 2 87  ? -11.38781 -24.39603 -22.31050 1.000 24.40746  ? 1139 THR   B CA   1 
ATOM   2846 C  C    . THR   B 2 87  ? -11.45788 -24.50515 -23.82649 1.000 27.05530  ? 1139 THR   B C    1 
ATOM   2847 O  O    . THR   B 2 87  ? -10.43092 -24.74127 -24.47251 1.000 28.71016  ? 1139 THR   B O    1 
ATOM   2848 C  CB   . THR   B 2 87  ? -11.63189 -25.78097 -21.70039 1.000 24.36479  ? 1139 THR   B CB   1 
ATOM   2849 O  OG1  . THR   B 2 87  ? -13.02192 -26.09588 -21.80931 1.000 23.85343  ? 1139 THR   B OG1  1 
ATOM   2850 C  CG2  . THR   B 2 87  ? -11.22584 -25.82288 -20.24240 1.000 29.46614  ? 1139 THR   B CG2  1 
ATOM   2851 N  N    . HIS   B 2 88  ? -12.63588 -24.31111 -24.40847 1.000 24.88215  ? 1140 HIS   B N    1 
ATOM   2852 C  CA   . HIS   B 2 88  ? -12.81895 -24.60021 -25.82144 1.000 24.52199  ? 1140 HIS   B CA   1 
ATOM   2853 C  C    . HIS   B 2 88  ? -14.09792 -23.92015 -26.28044 1.000 25.14550  ? 1140 HIS   B C    1 
ATOM   2854 O  O    . HIS   B 2 88  ? -15.02588 -23.72402 -25.48743 1.000 24.08248  ? 1140 HIS   B O    1 
ATOM   2855 C  CB   . HIS   B 2 88  ? -12.88407 -26.11722 -26.03831 1.000 27.06037  ? 1140 HIS   B CB   1 
ATOM   2856 C  CG   . HIS   B 2 88  ? -12.92015 -26.52533 -27.47228 1.000 27.98834  ? 1140 HIS   B CG   1 
ATOM   2857 N  ND1  . HIS   B 2 88  ? -14.09819 -26.71230 -28.16622 1.000 27.37602  ? 1140 HIS   B ND1  1 
ATOM   2858 C  CD2  . HIS   B 2 88  ? -11.91820 -26.80647 -28.34029 1.000 25.51401  ? 1140 HIS   B CD2  1 
ATOM   2859 C  CE1  . HIS   B 2 88  ? -13.81726 -27.07742 -29.40420 1.000 30.51138  ? 1140 HIS   B CE1  1 
ATOM   2860 N  NE2  . HIS   B 2 88  ? -12.50327 -27.14152 -29.53625 1.000 25.41218  ? 1140 HIS   B NE2  1 
ATOM   2861 N  N    . LEU   B 2 89  ? -14.12694 -23.52425 -27.55447 1.000 24.99668  ? 1141 LEU   B N    1 
ATOM   2862 C  CA   . LEU   B 2 89  ? -15.30191 -22.86721 -28.10849 1.000 24.90868  ? 1141 LEU   B CA   1 
ATOM   2863 C  C    . LEU   B 2 89  ? -15.40899 -23.19432 -29.58946 1.000 27.11834  ? 1141 LEU   B C    1 
ATOM   2864 O  O    . LEU   B 2 89  ? -14.44804 -23.63244 -30.21845 1.000 25.95530  ? 1141 LEU   B O    1 
ATOM   2865 C  CB   . LEU   B 2 89  ? -15.27479 -21.34619 -27.87361 1.000 27.57684  ? 1141 LEU   B CB   1 
ATOM   2866 C  CG   . LEU   B 2 89  ? -14.07676 -20.59032 -28.41171 1.000 28.55266  ? 1141 LEU   B CG   1 
ATOM   2867 C  CD1  . LEU   B 2 89  ? -14.23380 -20.40743 -29.90172 1.000 29.50161  ? 1141 LEU   B CD1  1 
ATOM   2868 C  CD2  . LEU   B 2 89  ? -13.98163 -19.24727 -27.71182 1.000 29.62242  ? 1141 LEU   B CD2  1 
ATOM   2869 N  N    . GLU   B 2 90  ? -16.61299 -23.00927 -30.13143 1.000 25.20509  ? 1142 GLU   B N    1 
ATOM   2870 C  CA   . GLU   B 2 90  ? -16.84106 -23.29737 -31.53940 1.000 25.11592  ? 1142 GLU   B CA   1 
ATOM   2871 C  C    . GLU   B 2 90  ? -17.99202 -22.44933 -32.05442 1.000 28.15140  ? 1142 GLU   B C    1 
ATOM   2872 O  O    . GLU   B 2 90  ? -19.12201 -22.57521 -31.56337 1.000 23.92401  ? 1142 GLU   B O    1 
ATOM   2873 C  CB   . GLU   B 2 90  ? -17.16018 -24.77836 -31.77427 1.000 26.22750  ? 1142 GLU   B CB   1 
ATOM   2874 C  CG   . GLU   B 2 90  ? -17.31226 -25.11247 -33.25324 1.000 24.39051  ? 1142 GLU   B CG   1 
ATOM   2875 C  CD   . GLU   B 2 90  ? -17.93237 -26.49745 -33.52810 1.000 28.85133  ? 1142 GLU   B CD   1 
ATOM   2876 O  OE1  . GLU   B 2 90  ? -18.30039 -27.23535 -32.58303 1.000 25.50968  ? 1142 GLU   B OE1  1 
ATOM   2877 O  OE2  . GLU   B 2 90  ? -18.05343 -26.84553 -34.72207 1.000 33.11931  ? 1142 GLU   B OE2  1 
ATOM   2878 N  N    . PRO   B 2 91  ? -17.75599 -21.57542 -33.02550 1.000 29.10216  ? 1143 PRO   B N    1 
ATOM   2879 C  CA   . PRO   B 2 91  ? -18.86696 -20.84939 -33.64952 1.000 27.51873  ? 1143 PRO   B CA   1 
ATOM   2880 C  C    . PRO   B 2 91  ? -19.52606 -21.70143 -34.71943 1.000 28.70154  ? 1143 PRO   B C    1 
ATOM   2881 O  O    . PRO   B 2 91  ? -18.89015 -22.57052 -35.31738 1.000 30.27375  ? 1143 PRO   B O    1 
ATOM   2882 C  CB   . PRO   B 2 91  ? -18.18389 -19.62349 -34.26364 1.000 27.46288  ? 1143 PRO   B CB   1 
ATOM   2883 C  CG   . PRO   B 2 91  ? -16.79894 -20.11361 -34.59465 1.000 33.59247  ? 1143 PRO   B CG   1 
ATOM   2884 C  CD   . PRO   B 2 91  ? -16.44398 -21.18356 -33.57058 1.000 23.40947  ? 1143 PRO   B CD   1 
ATOM   2885 N  N    . SER   B 2 92  ? -20.82405 -21.46235 -34.93440 1.000 27.44935  ? 1144 SER   B N    1 
ATOM   2886 C  CA   . SER   B 2 92  ? -21.52814 -22.10239 -36.03932 1.000 26.18142  ? 1144 SER   B CA   1 
ATOM   2887 C  C    . SER   B 2 92  ? -21.09314 -21.46452 -37.35639 1.000 29.16164  ? 1144 SER   B C    1 
ATOM   2888 O  O    . SER   B 2 92  ? -20.64806 -20.31456 -37.39050 1.000 31.42450  ? 1144 SER   B O    1 
ATOM   2889 C  CB   . SER   B 2 92  ? -23.04812 -21.99126 -35.86628 1.000 28.17336  ? 1144 SER   B CB   1 
ATOM   2890 O  OG   . SER   B 2 92  ? -23.53403 -20.65224 -35.96937 1.000 28.35375  ? 1144 SER   B OG   1 
ATOM   2891 N  N    . ARG   B 2 93  ? -21.20223 -22.22660 -38.44933 1.000 31.48668  ? 1145 ARG   B N    1 
ATOM   2892 C  CA   . ARG   B 2 93  ? -20.72624 -21.70474 -39.73938 1.000 35.93717  ? 1145 ARG   B CA   1 
ATOM   2893 C  C    . ARG   B 2 93  ? -21.49817 -20.45872 -40.18145 1.000 35.08815  ? 1145 ARG   B C    1 
ATOM   2894 O  O    . ARG   B 2 93  ? -20.93913 -19.58881 -40.85054 1.000 33.19163  ? 1145 ARG   B O    1 
ATOM   2895 C  CB   . ARG   B 2 93  ? -20.80136 -22.77882 -40.82630 1.000 31.69740  ? 1145 ARG   B CB   1 
ATOM   2896 C  CG   . ARG   B 2 93  ? -19.65243 -23.80090 -40.78626 1.000 36.29403  ? 1145 ARG   B CG   1 
ATOM   2897 C  CD   . ARG   B 2 93  ? -19.58154 -24.66800 -42.07319 1.000 33.07169  ? 1145 ARG   B CD   1 
ATOM   2898 N  NE   . ARG   B 2 93  ? -20.82560 -25.37494 -42.35609 1.000 37.22504  ? 1145 ARG   B NE   1 
ATOM   2899 C  CZ   . ARG   B 2 93  ? -21.16067 -26.55287 -41.84298 1.000 39.40419  ? 1145 ARG   B CZ   1 
ATOM   2900 N  NH1  . ARG   B 2 93  ? -20.35468 -27.20186 -41.01396 1.000 36.54623  ? 1145 ARG   B NH1  1 
ATOM   2901 N  NH2  . ARG   B 2 93  ? -22.33572 -27.09381 -42.16490 1.000 33.79599  ? 1145 ARG   B NH2  1 
ATOM   2902 N  N    . ASP   B 2 94  ? -22.76114 -20.33659 -39.80142 1.000 32.58177  ? 1146 ASP   B N    1 
ATOM   2903 C  CA   . ASP   B 2 94  ? -23.55808 -19.20257 -40.23848 1.000 39.74964  ? 1146 ASP   B CA   1 
ATOM   2904 C  C    . ASP   B 2 94  ? -23.44896 -17.98651 -39.31558 1.000 38.62473  ? 1146 ASP   B C    1 
ATOM   2905 O  O    . ASP   B 2 94  ? -24.15189 -16.99747 -39.54263 1.000 39.68459  ? 1146 ASP   B O    1 
ATOM   2906 C  CB   . ASP   B 2 94  ? -25.02511 -19.62948 -40.38839 1.000 35.78859  ? 1146 ASP   B CB   1 
ATOM   2907 C  CG   . ASP   B 2 94  ? -25.68409 -19.94132 -39.06635 1.000 39.07494  ? 1146 ASP   B CG   1 
ATOM   2908 O  OD1  . ASP   B 2 94  ? -25.05704 -19.73029 -38.00239 1.000 39.42492  ? 1146 ASP   B OD1  1 
ATOM   2909 O  OD2  . ASP   B 2 94  ? -26.84512 -20.39624 -39.09727 1.000 42.86410  ? 1146 ASP   B OD2  1 
ATOM   2910 N  N    . GLY   B 2 95  ? -22.60092 -18.03049 -38.28961 1.000 38.75302  ? 1147 GLY   B N    1 
ATOM   2911 C  CA   . GLY   B 2 95  ? -22.38581 -16.87543 -37.42971 1.000 38.31687  ? 1147 GLY   B CA   1 
ATOM   2912 C  C    . GLY   B 2 95  ? -23.47375 -16.58727 -36.41169 1.000 35.21879  ? 1147 GLY   B C    1 
ATOM   2913 O  O    . GLY   B 2 95  ? -23.36065 -15.60622 -35.66377 1.000 35.23941  ? 1147 GLY   B O    1 
ATOM   2914 N  N    . SER   B 2 96  ? -24.51881 -17.39619 -36.34459 1.000 33.45711  ? 1148 SER   B N    1 
ATOM   2915 C  CA   . SER   B 2 96  ? -25.61675 -17.09204 -35.44157 1.000 39.82667  ? 1148 SER   B CA   1 
ATOM   2916 C  C    . SER   B 2 96  ? -25.46075 -17.70994 -34.04853 1.000 35.33022  ? 1148 SER   B C    1 
ATOM   2917 O  O    . SER   B 2 96  ? -26.17869 -17.30582 -33.12954 1.000 37.09491  ? 1148 SER   B O    1 
ATOM   2918 C  CB   . SER   B 2 96  ? -26.93481 -17.56000 -36.06749 1.000 36.01002  ? 1148 SER   B CB   1 
ATOM   2919 O  OG   . SER   B 2 96  ? -26.91692 -18.96102 -36.28438 1.000 41.49917  ? 1148 SER   B OG   1 
ATOM   2920 N  N    . LEU   B 2 97  ? -24.55681 -18.67400 -33.86949 1.000 32.60359  ? 1149 LEU   B N    1 
ATOM   2921 C  CA   . LEU   B 2 97  ? -24.52483 -19.47190 -32.65242 1.000 30.48968  ? 1149 LEU   B CA   1 
ATOM   2922 C  C    . LEU   B 2 97  ? -23.08783 -19.73197 -32.22246 1.000 31.28939  ? 1149 LEU   B C    1 
ATOM   2923 O  O    . LEU   B 2 97  ? -22.15886 -19.74610 -33.03849 1.000 26.87414  ? 1149 LEU   B O    1 
ATOM   2924 C  CB   . LEU   B 2 97  ? -25.24393 -20.80786 -32.83829 1.000 28.25255  ? 1149 LEU   B CB   1 
ATOM   2925 C  CG   . LEU   B 2 97  ? -26.73894 -20.75278 -33.11924 1.000 30.85518  ? 1149 LEU   B CG   1 
ATOM   2926 C  CD1  . LEU   B 2 97  ? -27.23105 -22.16376 -33.38812 1.000 30.17394  ? 1149 LEU   B CD1  1 
ATOM   2927 C  CD2  . LEU   B 2 97  ? -27.46785 -20.14263 -31.92427 1.000 32.54627  ? 1149 LEU   B CD2  1 
ATOM   2928 N  N    . LEU   B 2 98  ? -22.91980 -19.96788 -30.92244 1.000 27.77279  ? 1150 LEU   B N    1 
ATOM   2929 C  CA   . LEU   B 2 98  ? -21.60580 -20.25493 -30.36447 1.000 27.06299  ? 1150 LEU   B CA   1 
ATOM   2930 C  C    . LEU   B 2 98  ? -21.72683 -21.26783 -29.23938 1.000 27.86122  ? 1150 LEU   B C    1 
ATOM   2931 O  O    . LEU   B 2 98  ? -22.58279 -21.12770 -28.35936 1.000 27.41806  ? 1150 LEU   B O    1 
ATOM   2932 C  CB   . LEU   B 2 98  ? -20.93469 -18.96694 -29.85459 1.000 27.09185  ? 1150 LEU   B CB   1 
ATOM   2933 C  CG   . LEU   B 2 98  ? -19.57768 -19.15298 -29.17663 1.000 28.25616  ? 1150 LEU   B CG   1 
ATOM   2934 C  CD1  . LEU   B 2 98  ? -18.46973 -19.41414 -30.19865 1.000 26.30987  ? 1150 LEU   B CD1  1 
ATOM   2935 C  CD2  . LEU   B 2 98  ? -19.25356 -17.93694 -28.30773 1.000 29.00063  ? 1150 LEU   B CD2  1 
ATOM   2936 N  N    . LEU   B 2 99  ? -20.84491 -22.26590 -29.25533 1.000 24.78148  ? 1151 LEU   B N    1 
ATOM   2937 C  CA   . LEU   B 2 99  ? -20.67993 -23.18582 -28.13927 1.000 25.02777  ? 1151 LEU   B CA   1 
ATOM   2938 C  C    . LEU   B 2 99  ? -19.47187 -22.77084 -27.31634 1.000 24.09195  ? 1151 LEU   B C    1 
ATOM   2939 O  O    . LEU   B 2 99  ? -18.43687 -22.37296 -27.86141 1.000 24.45223  ? 1151 LEU   B O    1 
ATOM   2940 C  CB   . LEU   B 2 99  ? -20.49606 -24.62987 -28.63816 1.000 25.10731  ? 1151 LEU   B CB   1 
ATOM   2941 C  CG   . LEU   B 2 99  ? -21.72813 -25.27384 -29.28207 1.000 24.10453  ? 1151 LEU   B CG   1 
ATOM   2942 C  CD1  . LEU   B 2 99  ? -21.32325 -26.56193 -30.04298 1.000 24.45206  ? 1151 LEU   B CD1  1 
ATOM   2943 C  CD2  . LEU   B 2 99  ? -22.75411 -25.58368 -28.20700 1.000 23.46945  ? 1151 LEU   B CD2  1 
ATOM   2944 N  N    . THR   B 2 100 ? -19.60384 -22.87873 -26.00333 1.000 23.51959  ? 1152 THR   B N    1 
ATOM   2945 C  CA   . THR   B 2 100 ? -18.48379 -22.69474 -25.09839 1.000 19.85535  ? 1152 THR   B CA   1 
ATOM   2946 C  C    . THR   B 2 100 ? -18.43784 -23.84167 -24.10630 1.000 23.99791  ? 1152 THR   B C    1 
ATOM   2947 O  O    . THR   B 2 100 ? -19.46987 -24.40956 -23.73621 1.000 22.75588  ? 1152 THR   B O    1 
ATOM   2948 C  CB   . THR   B 2 100 ? -18.57967 -21.36867 -24.31149 1.000 22.08675  ? 1152 THR   B CB   1 
ATOM   2949 O  OG1  . THR   B 2 100 ? -19.83764 -21.31553 -23.63845 1.000 23.61876  ? 1152 THR   B OG1  1 
ATOM   2950 C  CG2  . THR   B 2 100 ? -18.45861 -20.14575 -25.24959 1.000 22.84365  ? 1152 THR   B CG2  1 
ATOM   2951 N  N    . SER   B 2 101 ? -17.23184 -24.13872 -23.64332 1.000 19.89368  ? 1153 SER   B N    1 
ATOM   2952 C  CA   . SER   B 2 101 ? -17.03087 -25.05464 -22.53325 1.000 22.02837  ? 1153 SER   B CA   1 
ATOM   2953 C  C    . SER   B 2 101 ? -16.11678 -24.37963 -21.52334 1.000 26.73697  ? 1153 SER   B C    1 
ATOM   2954 O  O    . SER   B 2 101 ? -15.18675 -23.65573 -21.90143 1.000 26.79281  ? 1153 SER   B O    1 
ATOM   2955 C  CB   . SER   B 2 101 ? -16.42398 -26.37072 -23.00217 1.000 21.94178  ? 1153 SER   B CB   1 
ATOM   2956 O  OG   . SER   B 2 101 ? -17.28606 -26.96974 -23.96009 1.000 27.63718  ? 1153 SER   B OG   1 
ATOM   2957 N  N    . ALA   B 2 102 ? -16.38576 -24.60751 -20.24031 1.000 24.08554  ? 1154 ALA   B N    1 
ATOM   2958 C  CA   . ALA   B 2 102 ? -15.60968 -24.05148 -19.15038 1.000 26.02569  ? 1154 ALA   B CA   1 
ATOM   2959 C  C    . ALA   B 2 102 ? -14.77173 -25.16249 -18.51432 1.000 25.43546  ? 1154 ALA   B C    1 
ATOM   2960 O  O    . ALA   B 2 102 ? -14.44683 -26.15256 -19.18526 1.000 28.04013  ? 1154 ALA   B O    1 
ATOM   2961 C  CB   . ALA   B 2 102 ? -16.54459 -23.33333 -18.17940 1.000 22.22188  ? 1154 ALA   B CB   1 
ATOM   2962 N  N    . THR   B 2 103 ? -14.40168 -24.99741 -17.24835 1.000 23.88296  ? 1155 THR   B N    1 
ATOM   2963 C  CA   . THR   B 2 103 ? -13.45672 -25.91043 -16.61731 1.000 24.10638  ? 1155 THR   B CA   1 
ATOM   2964 C  C    . THR   B 2 103 ? -14.11674 -26.77830 -15.55222 1.000 30.55150  ? 1155 THR   B C    1 
ATOM   2965 O  O    . THR   B 2 103 ? -14.11884 -28.00831 -15.66512 1.000 27.87317  ? 1155 THR   B O    1 
ATOM   2966 C  CB   . THR   B 2 103 ? -12.29164 -25.10547 -16.03442 1.000 29.19910  ? 1155 THR   B CB   1 
ATOM   2967 O  OG1  . THR   B 2 103 ? -11.60363 -24.45261 -17.11449 1.000 28.95753  ? 1155 THR   B OG1  1 
ATOM   2968 C  CG2  . THR   B 2 103 ? -11.30668 -26.02249 -15.31638 1.000 33.03391  ? 1155 THR   B CG2  1 
ATOM   2969 N  N    . TRP   B 2 104 ? -14.72166 -26.16918 -14.53424 1.000 24.75638  ? 1156 TRP   B N    1 
ATOM   2970 C  CA   . TRP   B 2 104 ? -15.31868 -26.92705 -13.45016 1.000 28.62206  ? 1156 TRP   B CA   1 
ATOM   2971 C  C    . TRP   B 2 104 ? -16.70263 -26.44392 -13.07215 1.000 28.98730  ? 1156 TRP   B C    1 
ATOM   2972 O  O    . TRP   B 2 104 ? -17.43866 -27.20781 -12.43807 1.000 30.02223  ? 1156 TRP   B O    1 
ATOM   2973 C  CB   . TRP   B 2 104 ? -14.41163 -26.89601 -12.20620 1.000 28.74403  ? 1156 TRP   B CB   1 
ATOM   2974 C  CG   . TRP   B 2 104 ? -14.15152 -25.49899 -11.70332 1.000 30.30554  ? 1156 TRP   B CG   1 
ATOM   2975 C  CD1  . TRP   B 2 104 ? -13.06147 -24.71609 -11.97342 1.000 29.27642  ? 1156 TRP   B CD1  1 
ATOM   2976 C  CD2  . TRP   B 2 104 ? -15.00543 -24.71886 -10.85135 1.000 24.94640  ? 1156 TRP   B CD2  1 
ATOM   2977 N  NE1  . TRP   B 2 104 ? -13.18036 -23.49503 -11.33351 1.000 30.88227  ? 1156 TRP   B NE1  1 
ATOM   2978 C  CE2  . TRP   B 2 104 ? -14.36133 -23.47989 -10.63447 1.000 31.16793  ? 1156 TRP   B CE2  1 
ATOM   2979 C  CE3  . TRP   B 2 104 ? -16.24542 -24.95473 -10.24429 1.000 26.80356  ? 1156 TRP   B CE3  1 
ATOM   2980 C  CZ2  . TRP   B 2 104 ? -14.92723 -22.46779 -9.84653  1.000 31.54344  ? 1156 TRP   B CZ2  1 
ATOM   2981 C  CZ3  . TRP   B 2 104 ? -16.79732 -23.95762 -9.45735  1.000 29.92905  ? 1156 TRP   B CZ3  1 
ATOM   2982 C  CH2  . TRP   B 2 104 ? -16.13823 -22.72666 -9.26447  1.000 26.48269  ? 1156 TRP   B CH2  1 
ATOM   2983 N  N    . SER   B 2 105 ? -17.09356 -25.23092 -13.46423 1.000 26.00398  ? 1157 SER   B N    1 
ATOM   2984 C  CA   . SER   B 2 105 ? -18.31850 -24.60979 -12.98024 1.000 27.69076  ? 1157 SER   B CA   1 
ATOM   2985 C  C    . SER   B 2 105 ? -19.48756 -25.01778 -13.86617 1.000 26.10728  ? 1157 SER   B C    1 
ATOM   2986 O  O    . SER   B 2 105 ? -19.33761 -25.17189 -15.08016 1.000 25.26868  ? 1157 SER   B O    1 
ATOM   2987 C  CB   . SER   B 2 105 ? -18.18239 -23.07980 -12.96437 1.000 26.01308  ? 1157 SER   B CB   1 
ATOM   2988 O  OG   . SER   B 2 105 ? -17.76339 -22.57293 -14.24842 1.000 26.61459  ? 1157 SER   B OG   1 
ATOM   2989 N  N    . GLN   B 2 106 ? -20.65355 -25.18265 -13.25211 1.000 24.83607  ? 1158 GLN   B N    1 
ATOM   2990 C  CA   . GLN   B 2 106 ? -21.83060 -25.52962 -14.03404 1.000 25.66363  ? 1158 GLN   B CA   1 
ATOM   2991 C  C    . GLN   B 2 106 ? -22.63152 -24.28259 -14.35711 1.000 26.41484  ? 1158 GLN   B C    1 
ATOM   2992 O  O    . GLN   B 2 106 ? -22.73443 -23.38552 -13.52618 1.000 26.63758  ? 1158 GLN   B O    1 
ATOM   2993 C  CB   . GLN   B 2 106 ? -22.72165 -26.52550 -13.28493 1.000 25.50541  ? 1158 GLN   B CB   1 
ATOM   2994 C  CG   . GLN   B 2 106 ? -22.08274 -27.88453 -13.13785 1.000 24.98209  ? 1158 GLN   B CG   1 
ATOM   2995 C  CD   . GLN   B 2 106 ? -22.95978 -28.88841 -12.37974 1.000 33.59217  ? 1158 GLN   B CD   1 
ATOM   2996 O  OE1  . GLN   B 2 106 ? -23.85573 -28.51229 -11.61973 1.000 41.73417  ? 1158 GLN   B OE1  1 
ATOM   2997 N  NE2  . GLN   B 2 106 ? -22.70688 -30.16745 -12.60464 1.000 34.34385  ? 1158 GLN   B NE2  1 
ATOM   2998 N  N    . PRO   B 2 107 ? -23.21356 -24.21464 -15.55110 1.000 26.56188  ? 1159 PRO   B N    1 
ATOM   2999 C  CA   . PRO   B 2 107 ? -23.16667 -25.23773 -16.60602 1.000 22.69684  ? 1159 PRO   B CA   1 
ATOM   3000 C  C    . PRO   B 2 107 ? -21.77570 -25.36188 -17.24806 1.000 24.17826  ? 1159 PRO   B C    1 
ATOM   3001 O  O    . PRO   B 2 107 ? -21.16864 -24.35095 -17.56316 1.000 20.74754  ? 1159 PRO   B O    1 
ATOM   3002 C  CB   . PRO   B 2 107 ? -24.21067 -24.74273 -17.61302 1.000 24.06546  ? 1159 PRO   B CB   1 
ATOM   3003 C  CG   . PRO   B 2 107 ? -24.26156 -23.24071 -17.41414 1.000 24.82529  ? 1159 PRO   B CG   1 
ATOM   3004 C  CD   . PRO   B 2 107 ? -24.02749 -23.04661 -15.93216 1.000 26.93301  ? 1159 PRO   B CD   1 
ATOM   3005 N  N    . LEU   B 2 108 ? -21.27480 -26.58593 -17.45998 1.000 26.04117  ? 1160 LEU   B N    1 
ATOM   3006 C  CA   . LEU   B 2 108 ? -19.94183 -26.76408 -18.03901 1.000 22.91589  ? 1160 LEU   B CA   1 
ATOM   3007 C  C    . LEU   B 2 108 ? -19.86485 -26.28820 -19.48605 1.000 22.92217  ? 1160 LEU   B C    1 
ATOM   3008 O  O    . LEU   B 2 108 ? -18.80883 -25.82431 -19.91713 1.000 25.33163  ? 1160 LEU   B O    1 
ATOM   3009 C  CB   . LEU   B 2 108 ? -19.51993 -28.22110 -17.93391 1.000 23.28719  ? 1160 LEU   B CB   1 
ATOM   3010 C  CG   . LEU   B 2 108 ? -19.09391 -28.59002 -16.50090 1.000 26.68327  ? 1160 LEU   B CG   1 
ATOM   3011 C  CD1  . LEU   B 2 108 ? -19.00801 -30.06101 -16.35078 1.000 27.02423  ? 1160 LEU   B CD1  1 
ATOM   3012 C  CD2  . LEU   B 2 108 ? -17.74885 -27.91008 -16.11500 1.000 26.05593  ? 1160 LEU   B CD2  1 
ATOM   3013 N  N    . SER   B 2 109 ? -20.94588 -26.38018 -20.24101 1.000 22.60182  ? 1161 SER   B N    1 
ATOM   3014 C  CA   . SER   B 2 109 ? -20.96690 -25.91629 -21.61904 1.000 22.49310  ? 1161 SER   B CA   1 
ATOM   3015 C  C    . SER   B 2 109 ? -22.26185 -25.16321 -21.87406 1.000 25.25906  ? 1161 SER   B C    1 
ATOM   3016 O  O    . SER   B 2 109 ? -23.27185 -25.39209 -21.20300 1.000 24.54343  ? 1161 SER   B O    1 
ATOM   3017 C  CB   . SER   B 2 109 ? -20.84102 -27.07537 -22.60395 1.000 19.96540  ? 1161 SER   B CB   1 
ATOM   3018 O  OG   . SER   B 2 109 ? -19.59406 -27.71045 -22.43895 1.000 26.05711  ? 1161 SER   B OG   1 
ATOM   3019 N  N    . ALA   B 2 110 ? -22.22382 -24.26229 -22.85213 1.000 22.53344  ? 1162 ALA   B N    1 
ATOM   3020 C  CA   . ALA   B 2 110 ? -23.38978 -23.46323 -23.17815 1.000 25.33239  ? 1162 ALA   B CA   1 
ATOM   3021 C  C    . ALA   B 2 110 ? -23.43581 -23.18835 -24.67817 1.000 28.95982  ? 1162 ALA   B C    1 
ATOM   3022 O  O    . ALA   B 2 110 ? -22.42484 -23.25948 -25.38820 1.000 26.97928  ? 1162 ALA   B O    1 
ATOM   3023 C  CB   . ALA   B 2 110 ? -23.39865 -22.15717 -22.37825 1.000 22.77018  ? 1162 ALA   B CB   1 
ATOM   3024 N  N    . LEU   B 2 111 ? -24.64081 -22.87830 -25.14515 1.000 25.99624  ? 1163 LEU   B N    1 
ATOM   3025 C  CA   . LEU   B 2 111 ? -24.91582 -22.43239 -26.50318 1.000 25.98503  ? 1163 LEU   B CA   1 
ATOM   3026 C  C    . LEU   B 2 111 ? -25.41172 -20.99235 -26.44627 1.000 29.01915  ? 1163 LEU   B C    1 
ATOM   3027 O  O    . LEU   B 2 111 ? -26.37667 -20.69222 -25.72826 1.000 27.22785  ? 1163 LEU   B O    1 
ATOM   3028 C  CB   . LEU   B 2 111 ? -25.96791 -23.32736 -27.15907 1.000 24.07910  ? 1163 LEU   B CB   1 
ATOM   3029 C  CG   . LEU   B 2 111 ? -26.42593 -22.89844 -28.55409 1.000 30.99584  ? 1163 LEU   B CG   1 
ATOM   3030 C  CD1  . LEU   B 2 111 ? -25.27697 -23.04960 -29.55911 1.000 26.10497  ? 1163 LEU   B CD1  1 
ATOM   3031 C  CD2  . LEU   B 2 111 ? -27.62400 -23.71739 -28.96998 1.000 28.98362  ? 1163 LEU   B CD2  1 
ATOM   3032 N  N    . TRP   B 2 112 ? -24.75668 -20.11145 -27.19637 1.000 25.96479  ? 1164 TRP   B N    1 
ATOM   3033 C  CA   . TRP   B 2 112 ? -25.03957 -18.67943 -27.16547 1.000 29.52850  ? 1164 TRP   B CA   1 
ATOM   3034 C  C    . TRP   B 2 112 ? -25.59359 -18.19449 -28.49749 1.000 31.59092  ? 1164 TRP   B C    1 
ATOM   3035 O  O    . TRP   B 2 112 ? -25.09065 -18.56462 -29.56248 1.000 32.50429  ? 1164 TRP   B O    1 
ATOM   3036 C  CB   . TRP   B 2 112 ? -23.77550 -17.88550 -26.84658 1.000 25.88041  ? 1164 TRP   B CB   1 
ATOM   3037 C  CG   . TRP   B 2 112 ? -23.11050 -18.38145 -25.63656 1.000 26.40054  ? 1164 TRP   B CG   1 
ATOM   3038 C  CD1  . TRP   B 2 112 ? -22.17657 -19.36151 -25.55952 1.000 25.81439  ? 1164 TRP   B CD1  1 
ATOM   3039 C  CD2  . TRP   B 2 112 ? -23.34942 -17.93333 -24.29959 1.000 28.79264  ? 1164 TRP   B CD2  1 
ATOM   3040 N  NE1  . TRP   B 2 112 ? -21.79953 -19.55443 -24.24152 1.000 28.42922  ? 1164 TRP   B NE1  1 
ATOM   3041 C  CE2  . TRP   B 2 112 ? -22.51744 -18.68832 -23.45056 1.000 27.48098  ? 1164 TRP   B CE2  1 
ATOM   3042 C  CE3  . TRP   B 2 112 ? -24.19133 -16.96022 -23.73564 1.000 27.05044  ? 1164 TRP   B CE3  1 
ATOM   3043 C  CZ2  . TRP   B 2 112 ? -22.48638 -18.49121 -22.06557 1.000 25.94200  ? 1164 TRP   B CZ2  1 
ATOM   3044 C  CZ3  . TRP   B 2 112 ? -24.16927 -16.78311 -22.36965 1.000 29.29815  ? 1164 TRP   B CZ3  1 
ATOM   3045 C  CH2  . TRP   B 2 112 ? -23.32029 -17.54111 -21.54962 1.000 25.77673  ? 1164 TRP   B CH2  1 
ATOM   3046 N  N    . GLY   B 2 113 ? -26.61152 -17.33842 -28.42352 1.000 33.17402  ? 1165 GLY   B N    1 
ATOM   3047 C  CA   . GLY   B 2 113 ? -27.12252 -16.66847 -29.60555 1.000 31.58206  ? 1165 GLY   B CA   1 
ATOM   3048 C  C    . GLY   B 2 113 ? -26.28144 -15.43955 -29.87468 1.000 37.88297  ? 1165 GLY   B C    1 
ATOM   3049 O  O    . GLY   B 2 113 ? -26.05534 -14.61450 -28.98275 1.000 39.33753  ? 1165 GLY   B O    1 
ATOM   3050 N  N    . MET   B 2 114 ? -25.79547 -15.31869 -31.10371 1.000 42.43248  ? 1166 MET   B N    1 
ATOM   3051 C  CA   . MET   B 2 114 ? -24.94740 -14.18877 -31.44283 1.000 45.81698  ? 1166 MET   B CA   1 
ATOM   3052 C  C    . MET   B 2 114 ? -25.65735 -13.12679 -32.26789 1.000 49.47384  ? 1166 MET   B C    1 
ATOM   3053 O  O    . MET   B 2 114 ? -25.22727 -11.96882 -32.25199 1.000 60.55941  ? 1166 MET   B O    1 
ATOM   3054 C  CB   . MET   B 2 114 ? -23.69946 -14.68792 -32.16983 1.000 41.53380  ? 1166 MET   B CB   1 
ATOM   3055 C  CG   . MET   B 2 114 ? -22.95151 -15.68491 -31.32278 1.000 41.58954  ? 1166 MET   B CG   1 
ATOM   3056 S  SD   . MET   B 2 114 ? -21.20248 -15.37904 -31.31387 1.000 48.24944  ? 1166 MET   B SD   1 
ATOM   3057 C  CE   . MET   B 2 114 ? -20.75460 -16.30018 -32.76081 1.000 36.94913  ? 1166 MET   B CE   1 
ATOM   3058 N  N    . LYS   B 2 115 ? -26.73940 -13.48376 -32.95682 1.000 52.04211  ? 1167 LYS   B N    1 
ATOM   3059 C  CA   . LYS   B 2 115 ? -27.55736 -12.47876 -33.62787 1.000 55.02480  ? 1167 LYS   B CA   1 
ATOM   3060 C  C    . LYS   B 2 115 ? -28.06325 -11.45364 -32.61593 1.000 60.89767  ? 1167 LYS   B C    1 
ATOM   3061 O  O    . LYS   B 2 115 ? -28.49823 -11.80152 -31.51289 1.000 61.62864  ? 1167 LYS   B O    1 
ATOM   3062 C  CB   . LYS   B 2 115 ? -28.73243 -13.14573 -34.35478 1.000 56.66858  ? 1167 LYS   B CB   1 
ATOM   3063 C  CG   . LYS   B 2 115 ? -28.33553 -13.82986 -35.66374 1.000 57.53878  ? 1167 LYS   B CG   1 
ATOM   3064 C  CD   . LYS   B 2 115 ? -29.51360 -14.52283 -36.35664 1.000 60.48498  ? 1167 LYS   B CD   1 
ATOM   3065 C  CE   . LYS   B 2 115 ? -30.07665 -15.66073 -35.51253 1.000 61.38100  ? 1167 LYS   B CE   1 
ATOM   3066 N  NZ   . LYS   B 2 115 ? -31.01274 -16.52172 -36.29543 1.000 63.69060  ? 1167 LYS   B NZ   1 
ATOM   3067 N  N    . SER   B 2 116 ? -27.99117 -10.17568 -32.99504 1.000 60.28177  ? 1168 SER   B N    1 
ATOM   3068 C  CA   . SER   B 2 116 ? -28.34505 -9.07558  -32.10111 1.000 62.36136  ? 1168 SER   B CA   1 
ATOM   3069 C  C    . SER   B 2 116 ? -27.67602 -9.22352  -30.73512 1.000 60.07255  ? 1168 SER   B C    1 
ATOM   3070 O  O    . SER   B 2 116 ? -26.44402 -9.27360  -30.64216 1.000 64.95236  ? 1168 SER   B O    1 
ATOM   3071 C  CB   . SER   B 2 116 ? -29.87204 -8.96546  -31.95407 1.000 65.51724  ? 1168 SER   B CB   1 
ATOM   3072 O  OG   . SER   B 2 116 ? -30.49413 -10.23040 -31.77794 1.000 64.60355  ? 1168 SER   B OG   1 
ATOM   3073 N  N    . VAL   B 2 117 ? -28.47898 -9.29138  -29.67209 1.000 59.69844  ? 1169 VAL   B N    1 
ATOM   3074 C  CA   . VAL   B 2 117 ? -27.93894 -9.35231  -28.32110 1.000 55.39761  ? 1169 VAL   B CA   1 
ATOM   3075 C  C    . VAL   B 2 117 ? -27.31703 -10.71934 -28.07002 1.000 54.74206  ? 1169 VAL   B C    1 
ATOM   3076 O  O    . VAL   B 2 117 ? -27.96311 -11.76130 -28.23291 1.000 50.18720  ? 1169 VAL   B O    1 
ATOM   3077 C  CB   . VAL   B 2 117 ? -29.03488 -9.05015  -27.29209 1.000 54.57720  ? 1169 VAL   B CB   1 
ATOM   3078 C  CG1  . VAL   B 2 117 ? -29.22077 -7.54613  -27.15020 1.000 61.47381  ? 1169 VAL   B CG1  1 
ATOM   3079 C  CG2  . VAL   B 2 117 ? -30.33795 -9.72009  -27.71299 1.000 62.41461  ? 1169 VAL   B CG2  1 
ATOM   3080 N  N    . PHE   B 2 118 ? -26.05202 -10.71640 -27.66606 1.000 49.93249  ? 1170 PHE   B N    1 
ATOM   3081 C  CA   . PHE   B 2 118 ? -25.39109 -11.92341 -27.20499 1.000 41.69238  ? 1170 PHE   B CA   1 
ATOM   3082 C  C    . PHE   B 2 118 ? -26.08708 -12.44326 -25.95692 1.000 38.60932  ? 1170 PHE   B C    1 
ATOM   3083 O  O    . PHE   B 2 118 ? -26.10799 -11.76618 -24.92998 1.000 40.01274  ? 1170 PHE   B O    1 
ATOM   3084 C  CB   . PHE   B 2 118 ? -23.93005 -11.61449 -26.91107 1.000 37.95141  ? 1170 PHE   B CB   1 
ATOM   3085 C  CG   . PHE   B 2 118 ? -23.11713 -12.82252 -26.56900 1.000 37.82081  ? 1170 PHE   B CG   1 
ATOM   3086 C  CD1  . PHE   B 2 118 ? -22.51722 -13.57364 -27.57396 1.000 37.99899  ? 1170 PHE   B CD1  1 
ATOM   3087 C  CD2  . PHE   B 2 118 ? -22.95311 -13.21043 -25.24798 1.000 32.51846  ? 1170 PHE   B CD2  1 
ATOM   3088 C  CE1  . PHE   B 2 118 ? -21.76229 -14.69667 -27.26690 1.000 38.44429  ? 1170 PHE   B CE1  1 
ATOM   3089 C  CE2  . PHE   B 2 118 ? -22.20718 -14.33046 -24.92991 1.000 33.52550  ? 1170 PHE   B CE2  1 
ATOM   3090 C  CZ   . PHE   B 2 118 ? -21.61127 -15.08458 -25.93788 1.000 30.06690  ? 1170 PHE   B CZ   1 
ATOM   3091 N  N    . ASP   B 2 119 ? -26.65517 -13.64422 -26.03081 1.000 36.78513  ? 1171 ASP   B N    1 
ATOM   3092 C  CA   . ASP   B 2 119 ? -27.34117 -14.18908 -24.87074 1.000 39.88043  ? 1171 ASP   B CA   1 
ATOM   3093 C  C    . ASP   B 2 119 ? -27.29728 -15.71209 -24.92362 1.000 36.61859  ? 1171 ASP   B C    1 
ATOM   3094 O  O    . ASP   B 2 119 ? -27.06536 -16.31019 -25.97658 1.000 33.65285  ? 1171 ASP   B O    1 
ATOM   3095 C  CB   . ASP   B 2 119 ? -28.78813 -13.68297 -24.79873 1.000 41.98300  ? 1171 ASP   B CB   1 
ATOM   3096 C  CG   . ASP   B 2 119 ? -29.63321 -14.19400 -25.94966 1.000 49.70418  ? 1171 ASP   B CG   1 
ATOM   3097 O  OD1  . ASP   B 2 119 ? -29.07026 -14.43713 -27.04666 1.000 48.15100  ? 1171 ASP   B OD1  1 
ATOM   3098 O  OD2  . ASP   B 2 119 ? -30.85321 -14.38290 -25.75660 1.000 64.30384  ? 1171 ASP   B OD2  1 
ATOM   3099 N  N    . MET   B 2 120 ? -27.51528 -16.33598 -23.77257 1.000 32.02792  ? 1172 MET   B N    1 
ATOM   3100 C  CA   . MET   B 2 120 ? -27.48639 -17.78898 -23.68745 1.000 30.40888  ? 1172 MET   B CA   1 
ATOM   3101 C  C    . MET   B 2 120 ? -28.79445 -18.36693 -24.22036 1.000 34.58302  ? 1172 MET   B C    1 
ATOM   3102 O  O    . MET   B 2 120 ? -29.86840 -18.01281 -23.73635 1.000 37.20914  ? 1172 MET   B O    1 
ATOM   3103 C  CB   . MET   B 2 120 ? -27.24137 -18.22788 -22.24643 1.000 26.98888  ? 1172 MET   B CB   1 
ATOM   3104 C  CG   . MET   B 2 120 ? -27.43247 -19.72585 -22.06930 1.000 30.72062  ? 1172 MET   B CG   1 
ATOM   3105 S  SD   . MET   B 2 120 ? -27.15545 -20.27974 -20.38827 1.000 36.19074  ? 1172 MET   B SD   1 
ATOM   3106 C  CE   . MET   B 2 120 ? -25.43641 -19.90584 -20.07336 1.000 26.27551  ? 1172 MET   B CE   1 
ATOM   3107 N  N    . LYS   B 2 121 ? -28.70455 -19.26401 -25.20429 1.000 30.40278  ? 1173 LYS   B N    1 
ATOM   3108 C  CA   . LYS   B 2 121 ? -29.86062 -19.96597 -25.74220 1.000 30.42571  ? 1173 LYS   B CA   1 
ATOM   3109 C  C    . LYS   B 2 121 ? -30.17568 -21.22488 -24.93808 1.000 33.46884  ? 1173 LYS   B C    1 
ATOM   3110 O  O    . LYS   B 2 121 ? -31.34068 -21.47377 -24.60302 1.000 30.46886  ? 1173 LYS   B O    1 
ATOM   3111 C  CB   . LYS   B 2 121 ? -29.62769 -20.32910 -27.21817 1.000 36.05250  ? 1173 LYS   B CB   1 
ATOM   3112 C  CG   . LYS   B 2 121 ? -29.49264 -19.13418 -28.14027 1.000 40.00105  ? 1173 LYS   B CG   1 
ATOM   3113 C  CD   . LYS   B 2 121 ? -30.85460 -18.47211 -28.39928 1.000 51.53859  ? 1173 LYS   B CD   1 
ATOM   3114 C  CE   . LYS   B 2 121 ? -30.78149 -16.94311 -28.31240 1.000 54.08077  ? 1173 LYS   B CE   1 
ATOM   3115 N  NZ   . LYS   B 2 121 ? -32.07145 -16.28504 -28.69141 1.000 61.66542  ? 1173 LYS   B NZ   1 
ATOM   3116 N  N    . HIS   B 2 122 ? -29.15073 -22.02493 -24.63406 1.000 32.16756  ? 1174 HIS   B N    1 
ATOM   3117 C  CA   . HIS   B 2 122 ? -29.29779 -23.26986 -23.89095 1.000 31.13413  ? 1174 HIS   B CA   1 
ATOM   3118 C  C    . HIS   B 2 122 ? -28.01678 -23.54289 -23.11998 1.000 31.93678  ? 1174 HIS   B C    1 
ATOM   3119 O  O    . HIS   B 2 122 ? -26.95375 -23.00100 -23.42806 1.000 27.30883  ? 1174 HIS   B O    1 
ATOM   3120 C  CB   . HIS   B 2 122 ? -29.60491 -24.45991 -24.81085 1.000 28.74505  ? 1174 HIS   B CB   1 
ATOM   3121 C  CG   . HIS   B 2 122 ? -30.89392 -24.32488 -25.54981 1.000 28.95631  ? 1174 HIS   B CG   1 
ATOM   3122 N  ND1  . HIS   B 2 122 ? -32.11591 -24.37074 -24.92077 1.000 33.23177  ? 1174 HIS   B ND1  1 
ATOM   3123 C  CD2  . HIS   B 2 122 ? -31.15196 -24.13096 -26.86482 1.000 32.27245  ? 1174 HIS   B CD2  1 
ATOM   3124 C  CE1  . HIS   B 2 122 ? -33.07293 -24.20774 -25.81174 1.000 34.84618  ? 1174 HIS   B CE1  1 
ATOM   3125 N  NE2  . HIS   B 2 122 ? -32.51496 -24.05788 -26.99978 1.000 36.60594  ? 1174 HIS   B NE2  1 
ATOM   3126 N  N    . SER   B 2 123 ? -28.11981 -24.41681 -22.13191 1.000 25.27667  ? 1175 SER   B N    1 
ATOM   3127 C  CA   . SER   B 2 123 ? -26.96681 -24.79283 -21.33892 1.000 28.05474  ? 1175 SER   B CA   1 
ATOM   3128 C  C    . SER   B 2 123 ? -26.92091 -26.30882 -21.21380 1.000 32.00067  ? 1175 SER   B C    1 
ATOM   3129 O  O    . SER   B 2 123 ? -27.95896 -26.97975 -21.19471 1.000 33.10173  ? 1175 SER   B O    1 
ATOM   3130 C  CB   . SER   B 2 123 ? -27.01371 -24.14372 -19.96097 1.000 29.12579  ? 1175 SER   B CB   1 
ATOM   3131 O  OG   . SER   B 2 123 ? -28.15372 -24.59158 -19.25289 1.000 31.89075  ? 1175 SER   B OG   1 
ATOM   3132 N  N    . PHE   B 2 124 ? -25.70495 -26.84291 -21.14980 1.000 29.04686  ? 1176 PHE   B N    1 
ATOM   3133 C  CA   . PHE   B 2 124 ? -25.46005 -28.28092 -21.09569 1.000 29.37233  ? 1176 PHE   B CA   1 
ATOM   3134 C  C    . PHE   B 2 124 ? -24.69502 -28.48887 -19.79971 1.000 30.83188  ? 1176 PHE   B C    1 
ATOM   3135 O  O    . PHE   B 2 124 ? -23.47101 -28.34796 -19.76176 1.000 27.76855  ? 1176 PHE   B O    1 
ATOM   3136 C  CB   . PHE   B 2 124 ? -24.68813 -28.74307 -22.34969 1.000 27.15339  ? 1176 PHE   B CB   1 
ATOM   3137 C  CG   . PHE   B 2 124 ? -25.26714 -28.21113 -23.62271 1.000 23.70506  ? 1176 PHE   B CG   1 
ATOM   3138 C  CD1  . PHE   B 2 124 ? -26.48019 -28.70108 -24.10262 1.000 25.95867  ? 1176 PHE   B CD1  1 
ATOM   3139 C  CD2  . PHE   B 2 124 ? -24.64609 -27.17823 -24.31081 1.000 24.88027  ? 1176 PHE   B CD2  1 
ATOM   3140 C  CE1  . PHE   B 2 124 ? -27.04319 -28.18613 -25.26065 1.000 27.12365  ? 1176 PHE   B CE1  1 
ATOM   3141 C  CE2  . PHE   B 2 124 ? -25.18809 -26.66129 -25.48583 1.000 25.25711  ? 1176 PHE   B CE2  1 
ATOM   3142 C  CZ   . PHE   B 2 124 ? -26.38015 -27.17324 -25.97175 1.000 26.26571  ? 1176 PHE   B CZ   1 
ATOM   3143 N  N    . THR   B 2 125 ? -25.42000 -28.77273 -18.71266 1.000 31.08653  ? 1177 THR   B N    1 
ATOM   3144 C  CA   . THR   B 2 125 ? -24.86393 -28.42767 -17.40870 1.000 28.08682  ? 1177 THR   B CA   1 
ATOM   3145 C  C    . THR   B 2 125 ? -23.70598 -29.33472 -17.00467 1.000 27.71030  ? 1177 THR   B C    1 
ATOM   3146 O  O    . THR   B 2 125 ? -22.80792 -28.88873 -16.28074 1.000 27.52223  ? 1177 THR   B O    1 
ATOM   3147 C  CB   . THR   B 2 125 ? -25.95689 -28.40950 -16.31667 1.000 39.31326  ? 1177 THR   B CB   1 
ATOM   3148 O  OG1  . THR   B 2 125 ? -25.81894 -29.54245 -15.44858 1.000 44.01278  ? 1177 THR   B OG1  1 
ATOM   3149 C  CG2  . THR   B 2 125 ? -27.34391 -28.37545 -16.91362 1.000 29.42835  ? 1177 THR   B CG2  1 
ATOM   3150 N  N    . GLU   B 2 126 ? -23.67709 -30.58376 -17.46158 1.000 27.91741  ? 1178 GLU   B N    1 
ATOM   3151 C  CA   . GLU   B 2 126 ? -22.62714 -31.51280 -17.05454 1.000 26.17815  ? 1178 GLU   B CA   1 
ATOM   3152 C  C    . GLU   B 2 126 ? -21.67721 -31.90596 -18.18054 1.000 26.89794  ? 1178 GLU   B C    1 
ATOM   3153 O  O    . GLU   B 2 126 ? -20.79626 -32.74201 -17.95851 1.000 27.02946  ? 1178 GLU   B O    1 
ATOM   3154 C  CB   . GLU   B 2 126 ? -23.23521 -32.78671 -16.45742 1.000 33.60820  ? 1178 GLU   B CB   1 
ATOM   3155 C  CG   . GLU   B 2 126 ? -24.13415 -32.54555 -15.26440 1.000 36.73625  ? 1178 GLU   B CG   1 
ATOM   3156 C  CD   . GLU   B 2 126 ? -24.44922 -33.82747 -14.50229 1.000 45.34768  ? 1178 GLU   B CD   1 
ATOM   3157 O  OE1  . GLU   B 2 126 ? -24.82731 -34.84249 -15.13820 1.000 48.24029  ? 1178 GLU   B OE1  1 
ATOM   3158 O  OE2  . GLU   B 2 126 ? -24.30417 -33.81038 -13.26030 1.000 53.17854  ? 1178 GLU   B OE2  1 
ATOM   3159 N  N    . ASP   B 2 127 ? -21.80621 -31.32505 -19.36958 1.000 24.99592  ? 1179 ASP   B N    1 
ATOM   3160 C  CA   . ASP   B 2 127 ? -20.98528 -31.72220 -20.51258 1.000 24.13711  ? 1179 ASP   B CA   1 
ATOM   3161 C  C    . ASP   B 2 127 ? -19.71922 -30.86929 -20.52469 1.000 22.04470  ? 1179 ASP   B C    1 
ATOM   3162 O  O    . ASP   B 2 127 ? -19.78814 -29.66230 -20.77179 1.000 22.95423  ? 1179 ASP   B O    1 
ATOM   3163 C  CB   . ASP   B 2 127 ? -21.77632 -31.57924 -21.81356 1.000 22.85874  ? 1179 ASP   B CB   1 
ATOM   3164 C  CG   . ASP   B 2 127 ? -22.92039 -32.57717 -21.90844 1.000 30.27740  ? 1179 ASP   B CG   1 
ATOM   3165 O  OD1  . ASP   B 2 127 ? -22.66048 -33.79418 -21.86236 1.000 32.19133  ? 1179 ASP   B OD1  1 
ATOM   3166 O  OD2  . ASP   B 2 127 ? -24.08336 -32.14709 -21.98744 1.000 35.05315  ? 1179 ASP   B OD2  1 
ATOM   3167 N  N    . HIS   B 2 128 ? -18.56625 -31.49935 -20.25569 1.000 23.34132  ? 1180 HIS   B N    1 
ATOM   3168 C  CA   . HIS   B 2 128 ? -17.27720 -30.79944 -20.25379 1.000 24.93805  ? 1180 HIS   B CA   1 
ATOM   3169 C  C    . HIS   B 2 128 ? -16.85022 -30.33759 -21.64284 1.000 24.76395  ? 1180 HIS   B C    1 
ATOM   3170 O  O    . HIS   B 2 128 ? -15.94316 -29.50266 -21.76594 1.000 22.10597  ? 1180 HIS   B O    1 
ATOM   3171 C  CB   . HIS   B 2 128 ? -16.16825 -31.70448 -19.68275 1.000 26.59644  ? 1180 HIS   B CB   1 
ATOM   3172 C  CG   . HIS   B 2 128 ? -16.13520 -31.75536 -18.18475 1.000 36.58704  ? 1180 HIS   B CG   1 
ATOM   3173 N  ND1  . HIS   B 2 128 ? -15.39511 -30.87136 -17.42285 1.000 36.65851  ? 1180 HIS   B ND1  1 
ATOM   3174 C  CD2  . HIS   B 2 128 ? -16.74123 -32.58825 -17.30466 1.000 35.45965  ? 1180 HIS   B CD2  1 
ATOM   3175 C  CE1  . HIS   B 2 128 ? -15.55508 -31.15124 -16.14082 1.000 35.92833  ? 1180 HIS   B CE1  1 
ATOM   3176 N  NE2  . HIS   B 2 128 ? -16.36815 -32.18818 -16.04071 1.000 33.47809  ? 1180 HIS   B NE2  1 
ATOM   3177 N  N    . TYR   B 2 129 ? -17.43630 -30.89763 -22.68977 1.000 24.95283  ? 1181 TYR   B N    1 
ATOM   3178 C  CA   . TYR   B 2 129 ? -17.01032 -30.60076 -24.05081 1.000 23.75946  ? 1181 TYR   B CA   1 
ATOM   3179 C  C    . TYR   B 2 129 ? -18.22437 -30.72475 -24.95676 1.000 25.96532  ? 1181 TYR   B C    1 
ATOM   3180 O  O    . TYR   B 2 129 ? -19.07442 -31.59267 -24.73266 1.000 25.35137  ? 1181 TYR   B O    1 
ATOM   3181 C  CB   . TYR   B 2 129 ? -15.87841 -31.54788 -24.47778 1.000 24.17669  ? 1181 TYR   B CB   1 
ATOM   3182 C  CG   . TYR   B 2 129 ? -15.38744 -31.33703 -25.87881 1.000 30.03505  ? 1181 TYR   B CG   1 
ATOM   3183 C  CD1  . TYR   B 2 129 ? -14.40038 -30.38912 -26.15592 1.000 28.78264  ? 1181 TYR   B CD1  1 
ATOM   3184 C  CD2  . TYR   B 2 129 ? -15.88954 -32.10407 -26.94073 1.000 29.76334  ? 1181 TYR   B CD2  1 
ATOM   3185 C  CE1  . TYR   B 2 129 ? -13.92642 -30.18626 -27.46596 1.000 26.30348  ? 1181 TYR   B CE1  1 
ATOM   3186 C  CE2  . TYR   B 2 129 ? -15.41257 -31.92321 -28.24476 1.000 33.16901  ? 1181 TYR   B CE2  1 
ATOM   3187 C  CZ   . TYR   B 2 129 ? -14.43251 -30.95330 -28.49988 1.000 31.80977  ? 1181 TYR   B CZ   1 
ATOM   3188 O  OH   . TYR   B 2 129 ? -13.95954 -30.75944 -29.78491 1.000 28.44263  ? 1181 TYR   B OH   1 
ATOM   3189 N  N    . VAL   B 2 130 ? -18.31434 -29.84682 -25.96183 1.000 21.22840  ? 1182 VAL   B N    1 
ATOM   3190 C  CA   . VAL   B 2 130 ? -19.41637 -29.87582 -26.91278 1.000 25.27318  ? 1182 VAL   B CA   1 
ATOM   3191 C  C    . VAL   B 2 130 ? -18.90940 -29.50896 -28.30183 1.000 24.86439  ? 1182 VAL   B C    1 
ATOM   3192 O  O    . VAL   B 2 130 ? -17.94135 -28.75305 -28.46093 1.000 23.64874  ? 1182 VAL   B O    1 
ATOM   3193 C  CB   . VAL   B 2 130 ? -20.58029 -28.92070 -26.49982 1.000 23.08415  ? 1182 VAL   B CB   1 
ATOM   3194 C  CG1  . VAL   B 2 130 ? -21.28228 -29.45255 -25.25975 1.000 20.40779  ? 1182 VAL   B CG1  1 
ATOM   3195 C  CG2  . VAL   B 2 130 ? -20.04718 -27.52572 -26.22395 1.000 21.86858  ? 1182 VAL   B CG2  1 
ATOM   3196 N  N    . GLU   B 2 131 ? -19.60147 -30.03899 -29.31576 1.000 21.84321  ? 1183 GLU   B N    1 
ATOM   3197 C  CA   . GLU   B 2 131 ? -19.35750 -29.68812 -30.70180 1.000 23.76290  ? 1183 GLU   B CA   1 
ATOM   3198 C  C    . GLU   B 2 131 ? -20.69351 -29.59408 -31.41076 1.000 23.23390  ? 1183 GLU   B C    1 
ATOM   3199 O  O    . GLU   B 2 131 ? -21.65055 -30.26898 -31.03367 1.000 25.33385  ? 1183 GLU   B O    1 
ATOM   3200 C  CB   . GLU   B 2 131 ? -18.51160 -30.72824 -31.45875 1.000 25.53383  ? 1183 GLU   B CB   1 
ATOM   3201 C  CG   . GLU   B 2 131 ? -17.26761 -31.24627 -30.73775 1.000 24.02372  ? 1183 GLU   B CG   1 
ATOM   3202 C  CD   . GLU   B 2 131 ? -16.45471 -32.18741 -31.65171 1.000 27.72144  ? 1183 GLU   B CD   1 
ATOM   3203 O  OE1  . GLU   B 2 131 ? -17.00979 -32.72444 -32.65564 1.000 24.80386  ? 1183 GLU   B OE1  1 
ATOM   3204 O  OE2  . GLU   B 2 131 ? -15.25971 -32.38347 -31.37273 1.000 27.14831  ? 1183 GLU   B OE2  1 
ATOM   3205 N  N    . PHE   B 2 132 ? -20.73649 -28.77216 -32.45582 1.000 22.32629  ? 1184 PHE   B N    1 
ATOM   3206 C  CA   . PHE   B 2 132 ? -21.87253 -28.79115 -33.36578 1.000 28.18123  ? 1184 PHE   B CA   1 
ATOM   3207 C  C    . PHE   B 2 132 ? -21.84965 -30.05322 -34.21668 1.000 27.46058  ? 1184 PHE   B C    1 
ATOM   3208 O  O    . PHE   B 2 132 ? -20.78970 -30.62632 -34.48468 1.000 27.28407  ? 1184 PHE   B O    1 
ATOM   3209 C  CB   . PHE   B 2 132 ? -21.85647 -27.56622 -34.29188 1.000 23.69013  ? 1184 PHE   B CB   1 
ATOM   3210 C  CG   . PHE   B 2 132 ? -22.27335 -26.28914 -33.61497 1.000 25.36963  ? 1184 PHE   B CG   1 
ATOM   3211 C  CD1  . PHE   B 2 132 ? -23.54933 -26.15601 -33.08893 1.000 26.70251  ? 1184 PHE   B CD1  1 
ATOM   3212 C  CD2  . PHE   B 2 132 ? -21.39727 -25.21320 -33.52508 1.000 25.33200  ? 1184 PHE   B CD2  1 
ATOM   3213 C  CE1  . PHE   B 2 132 ? -23.93522 -24.95293 -32.44801 1.000 25.79721  ? 1184 PHE   B CE1  1 
ATOM   3214 C  CE2  . PHE   B 2 132 ? -21.78816 -24.01512 -32.88416 1.000 24.72255  ? 1184 PHE   B CE2  1 
ATOM   3215 C  CZ   . PHE   B 2 132 ? -23.04114 -23.89998 -32.35113 1.000 24.85675  ? 1184 PHE   B CZ   1 
ATOM   3216 N  N    . SER   B 2 133 ? -23.03469 -30.48217 -34.65361 1.000 28.34727  ? 1185 SER   B N    1 
ATOM   3217 C  CA   . SER   B 2 133 ? -23.07880 -31.39025 -35.78953 1.000 30.81716  ? 1185 SER   B CA   1 
ATOM   3218 C  C    . SER   B 2 133 ? -22.45479 -30.68539 -36.99861 1.000 32.60291  ? 1185 SER   B C    1 
ATOM   3219 O  O    . SER   B 2 133 ? -22.24570 -29.46041 -37.00672 1.000 27.67174  ? 1185 SER   B O    1 
ATOM   3220 C  CB   . SER   B 2 133 ? -24.51384 -31.85417 -36.07045 1.000 32.27801  ? 1185 SER   B CB   1 
ATOM   3221 O  OG   . SER   B 2 133 ? -25.44077 -30.77212 -36.24850 1.000 33.32036  ? 1185 SER   B OG   1 
ATOM   3222 N  N    . LYS   B 2 134 ? -22.13989 -31.47250 -38.02856 1.000 31.85107  ? 1186 LYS   B N    1 
ATOM   3223 C  CA   . LYS   B 2 134 ? -21.21889 -31.03065 -39.07163 1.000 31.59058  ? 1186 LYS   B CA   1 
ATOM   3224 C  C    . LYS   B 2 134 ? -21.89391 -30.67370 -40.38763 1.000 33.27052  ? 1186 LYS   B C    1 
ATOM   3225 O  O    . LYS   B 2 134 ? -21.66785 -29.58076 -40.91573 1.000 36.66273  ? 1186 LYS   B O    1 
ATOM   3226 C  CB   . LYS   B 2 134 ? -20.14798 -32.11274 -39.28358 1.000 28.29014  ? 1186 LYS   B CB   1 
ATOM   3227 C  CG   . LYS   B 2 134 ? -19.32794 -32.28570 -38.00260 1.000 27.22256  ? 1186 LYS   B CG   1 
ATOM   3228 C  CD   . LYS   B 2 134 ? -18.05701 -33.01581 -38.23658 1.000 29.98511  ? 1186 LYS   B CD   1 
ATOM   3229 C  CE   . LYS   B 2 134 ? -17.08894 -32.69279 -37.13264 1.000 32.30133  ? 1186 LYS   B CE   1 
ATOM   3230 N  NZ   . LYS   B 2 134 ? -16.68100 -33.89376 -36.37756 1.000 30.35012  ? 1186 LYS   B NZ   1 
ATOM   3231 N  N    . HIS   B 2 135 ? -22.71300 -31.56169 -40.93853 1.000 38.47001  ? 1187 HIS   B N    1 
ATOM   3232 C  CA   . HIS   B 2 135 ? -23.35002 -31.28474 -42.21353 1.000 36.68613  ? 1187 HIS   B CA   1 
ATOM   3233 C  C    . HIS   B 2 135 ? -24.43694 -30.23465 -42.02658 1.000 39.17605  ? 1187 HIS   B C    1 
ATOM   3234 O  O    . HIS   B 2 135 ? -24.32688 -29.10870 -42.52267 1.000 42.05901  ? 1187 HIS   B O    1 
ATOM   3235 C  CB   . HIS   B 2 135 ? -23.94014 -32.55375 -42.82241 1.000 39.89620  ? 1187 HIS   B CB   1 
ATOM   3236 C  CG   . HIS   B 2 135 ? -24.57617 -32.32781 -44.15341 1.000 44.81457  ? 1187 HIS   B CG   1 
ATOM   3237 N  ND1  . HIS   B 2 135 ? -23.84718 -31.99695 -45.27646 1.000 49.08212  ? 1187 HIS   B ND1  1 
ATOM   3238 C  CD2  . HIS   B 2 135 ? -25.87618 -32.32974 -44.53436 1.000 45.68647  ? 1187 HIS   B CD2  1 
ATOM   3239 C  CE1  . HIS   B 2 135 ? -24.66921 -31.82597 -46.29644 1.000 46.26005  ? 1187 HIS   B CE1  1 
ATOM   3240 N  NE2  . HIS   B 2 135 ? -25.90621 -32.02085 -45.87238 1.000 47.27115  ? 1187 HIS   B NE2  1 
ATOM   3241 N  N    . SER   B 2 136 ? -25.48994 -30.59952 -41.31451 1.000 39.22179  ? 1188 SER   B N    1 
ATOM   3242 C  CA   . SER   B 2 136 ? -26.52286 -29.66241 -40.91255 1.000 39.41591  ? 1188 SER   B CA   1 
ATOM   3243 C  C    . SER   B 2 136 ? -26.29778 -29.34331 -39.43758 1.000 37.65343  ? 1188 SER   B C    1 
ATOM   3244 O  O    . SER   B 2 136 ? -26.37982 -30.23424 -38.58951 1.000 33.88703  ? 1188 SER   B O    1 
ATOM   3245 C  CB   . SER   B 2 136 ? -27.90991 -30.25933 -41.14945 1.000 38.12810  ? 1188 SER   B CB   1 
ATOM   3246 O  OG   . SER   B 2 136 ? -28.91183 -29.26924 -40.98849 1.000 54.59187  ? 1188 SER   B OG   1 
ATOM   3247 N  N    . GLN   B 2 137 ? -25.97668 -28.08931 -39.13369 1.000 34.47092  ? 1189 GLN   B N    1 
ATOM   3248 C  CA   . GLN   B 2 137 ? -25.62761 -27.71823 -37.76373 1.000 31.71581  ? 1189 GLN   B CA   1 
ATOM   3249 C  C    . GLN   B 2 137 ? -26.90656 -27.45407 -36.96871 1.000 33.88099  ? 1189 GLN   B C    1 
ATOM   3250 O  O    . GLN   B 2 137 ? -27.20846 -26.34601 -36.53878 1.000 35.92726  ? 1189 GLN   B O    1 
ATOM   3251 C  CB   . GLN   B 2 137 ? -24.68852 -26.52329 -37.76086 1.000 32.56773  ? 1189 GLN   B CB   1 
ATOM   3252 C  CG   . GLN   B 2 137 ? -23.40057 -26.77445 -38.55089 1.000 30.59425  ? 1189 GLN   B CG   1 
ATOM   3253 C  CD   . GLN   B 2 137 ? -22.26548 -25.84850 -38.13500 1.000 32.40621  ? 1189 GLN   B CD   1 
ATOM   3254 O  OE1  . GLN   B 2 137 ? -22.33040 -24.63251 -38.32109 1.000 29.01611  ? 1189 GLN   B OE1  1 
ATOM   3255 N  NE2  . GLN   B 2 137 ? -21.20251 -26.43253 -37.58699 1.000 31.77532  ? 1189 GLN   B NE2  1 
ATOM   3256 N  N    . ASP   B 2 138 ? -27.69563 -28.50800 -36.81960 1.000 33.41332  ? 1190 ASP   B N    1 
ATOM   3257 C  CA   . ASP   B 2 138 ? -28.93860 -28.40785 -36.08356 1.000 36.64212  ? 1190 ASP   B CA   1 
ATOM   3258 C  C    . ASP   B 2 138 ? -28.85160 -29.09875 -34.74651 1.000 31.02489  ? 1190 ASP   B C    1 
ATOM   3259 O  O    . ASP   B 2 138 ? -29.83757 -29.10262 -34.01547 1.000 34.35126  ? 1190 ASP   B O    1 
ATOM   3260 C  CB   . ASP   B 2 138 ? -30.10467 -28.98883 -36.90347 1.000 36.91522  ? 1190 ASP   B CB   1 
ATOM   3261 C  CG   . ASP   B 2 138 ? -29.97878 -30.48186 -37.12236 1.000 38.59245  ? 1190 ASP   B CG   1 
ATOM   3262 O  OD1  . ASP   B 2 138 ? -28.86882 -31.02793 -36.94336 1.000 36.67751  ? 1190 ASP   B OD1  1 
ATOM   3263 O  OD2  . ASP   B 2 138 ? -30.99184 -31.11082 -37.49027 1.000 44.62804  ? 1190 ASP   B OD2  1 
ATOM   3264 N  N    . ARG   B 2 139 ? -27.69763 -29.65981 -34.39751 1.000 30.47181  ? 1191 ARG   B N    1 
ATOM   3265 C  CA   . ARG   B 2 139 ? -27.56564 -30.41372 -33.15945 1.000 30.02520  ? 1191 ARG   B CA   1 
ATOM   3266 C  C    . ARG   B 2 139 ? -26.22059 -30.11077 -32.51352 1.000 27.59118  ? 1191 ARG   B C    1 
ATOM   3267 O  O    . ARG   B 2 139 ? -25.29358 -29.60789 -33.15960 1.000 27.93550  ? 1191 ARG   B O    1 
ATOM   3268 C  CB   . ARG   B 2 139 ? -27.73475 -31.92773 -33.41032 1.000 29.76409  ? 1191 ARG   B CB   1 
ATOM   3269 C  CG   . ARG   B 2 139 ? -29.18779 -32.33664 -33.64524 1.000 33.15937  ? 1191 ARG   B CG   1 
ATOM   3270 C  CD   . ARG   B 2 139 ? -29.34191 -33.80066 -34.00312 1.000 36.99518  ? 1191 ARG   B CD   1 
ATOM   3271 N  NE   . ARG   B 2 139 ? -28.74598 -34.11781 -35.30112 1.000 44.18145  ? 1191 ARG   B NE   1 
ATOM   3272 C  CZ   . ARG   B 2 139 ? -28.56009 -35.35286 -35.76302 1.000 47.52597  ? 1191 ARG   B CZ   1 
ATOM   3273 N  NH1  . ARG   B 2 139 ? -28.89414 -36.41777 -35.04893 1.000 43.17021  ? 1191 ARG   B NH1  1 
ATOM   3274 N  NH2  . ARG   B 2 139 ? -28.02614 -35.52399 -36.97103 1.000 43.65031  ? 1191 ARG   B NH2  1 
ATOM   3275 N  N    . VAL   B 2 140 ? -26.14457 -30.42667 -31.21450 1.000 28.62681  ? 1192 VAL   B N    1 
ATOM   3276 C  CA   . VAL   B 2 140 ? -24.94053 -30.31869 -30.39855 1.000 25.79845  ? 1192 VAL   B CA   1 
ATOM   3277 C  C    . VAL   B 2 140 ? -24.64861 -31.69767 -29.82945 1.000 24.48699  ? 1192 VAL   B C    1 
ATOM   3278 O  O    . VAL   B 2 140 ? -25.57765 -32.41057 -29.42836 1.000 26.78624  ? 1192 VAL   B O    1 
ATOM   3279 C  CB   . VAL   B 2 140 ? -25.11842 -29.28059 -29.26463 1.000 25.32409  ? 1192 VAL   B CB   1 
ATOM   3280 C  CG1  . VAL   B 2 140 ? -23.89538 -29.23761 -28.37567 1.000 24.33679  ? 1192 VAL   B CG1  1 
ATOM   3281 C  CG2  . VAL   B 2 140 ? -25.42934 -27.89361 -29.85673 1.000 22.64842  ? 1192 VAL   B CG2  1 
ATOM   3282 N  N    . ILE   B 2 141 ? -23.37564 -32.10176 -29.83247 1.000 20.88852  ? 1193 ILE   B N    1 
ATOM   3283 C  CA   . ILE   B 2 141 ? -22.97670 -33.33074 -29.15338 1.000 23.78447  ? 1193 ILE   B CA   1 
ATOM   3284 C  C    . ILE   B 2 141 ? -22.08664 -32.96571 -27.97344 1.000 24.18588  ? 1193 ILE   B C    1 
ATOM   3285 O  O    . ILE   B 2 141 ? -21.06659 -32.27979 -28.13453 1.000 22.98281  ? 1193 ILE   B O    1 
ATOM   3286 C  CB   . ILE   B 2 141 ? -22.28281 -34.34086 -30.08433 1.000 21.86869  ? 1193 ILE   B CB   1 
ATOM   3287 C  CG1  . ILE   B 2 141 ? -21.99487 -35.61082 -29.29124 1.000 23.43181  ? 1193 ILE   B CG1  1 
ATOM   3288 C  CG2  . ILE   B 2 141 ? -21.00179 -33.76000 -30.72542 1.000 23.71159  ? 1193 ILE   B CG2  1 
ATOM   3289 C  CD1  . ILE   B 2 141 ? -21.87299 -36.85589 -30.14114 1.000 25.05436  ? 1193 ILE   B CD1  1 
ATOM   3290 N  N    . GLY   B 2 142 ? -22.49063 -33.41358 -26.78639 1.000 25.71112  ? 1194 GLY   B N    1 
ATOM   3291 C  CA   . GLY   B 2 142 ? -21.76356 -33.15754 -25.55844 1.000 25.32398  ? 1194 GLY   B CA   1 
ATOM   3292 C  C    . GLY   B 2 142 ? -21.12764 -34.43054 -25.03336 1.000 27.13803  ? 1194 GLY   B C    1 
ATOM   3293 O  O    . GLY   B 2 142 ? -21.64072 -35.53952 -25.24126 1.000 28.98258  ? 1194 GLY   B O    1 
ATOM   3294 N  N    . THR   B 2 143 ? -20.01060 -34.26257 -24.34142 1.000 25.46078  ? 1195 THR   B N    1 
ATOM   3295 C  CA   . THR   B 2 143 ? -19.30166 -35.35257 -23.70335 1.000 23.37245  ? 1195 THR   B CA   1 
ATOM   3296 C  C    . THR   B 2 143 ? -19.28159 -35.12845 -22.20537 1.000 27.29202  ? 1195 THR   B C    1 
ATOM   3297 O  O    . THR   B 2 143 ? -18.91049 -34.04244 -21.74447 1.000 24.59791  ? 1195 THR   B O    1 
ATOM   3298 C  CB   . THR   B 2 143 ? -17.86668 -35.44071 -24.19740 1.000 26.29786  ? 1195 THR   B CB   1 
ATOM   3299 O  OG1  . THR   B 2 143 ? -17.88374 -35.53783 -25.62239 1.000 29.07613  ? 1195 THR   B OG1  1 
ATOM   3300 C  CG2  . THR   B 2 143 ? -17.17375 -36.67371 -23.56233 1.000 26.89364  ? 1195 THR   B CG2  1 
ATOM   3301 N  N    . LYS   B 2 144 ? -19.66563 -36.16137 -21.45628 1.000 23.70052  ? 1196 LYS   B N    1 
ATOM   3302 C  CA   . LYS   B 2 144 ? -19.52358 -36.17826 -20.00128 1.000 26.56019  ? 1196 LYS   B CA   1 
ATOM   3303 C  C    . LYS   B 2 144 ? -18.80167 -37.47629 -19.66220 1.000 25.93227  ? 1196 LYS   B C    1 
ATOM   3304 O  O    . LYS   B 2 144 ? -19.40874 -38.55024 -19.66310 1.000 28.73305  ? 1196 LYS   B O    1 
ATOM   3305 C  CB   . LYS   B 2 144 ? -20.87455 -36.08111 -19.28924 1.000 25.59247  ? 1196 LYS   B CB   1 
ATOM   3306 C  CG   . LYS   B 2 144 ? -20.73650 -36.16600 -17.77024 1.000 31.83893  ? 1196 LYS   B CG   1 
ATOM   3307 C  CD   . LYS   B 2 144 ? -22.01652 -36.66585 -17.13115 1.000 37.70243  ? 1196 LYS   B CD   1 
ATOM   3308 C  CE   . LYS   B 2 144 ? -21.93646 -36.65374 -15.59916 1.000 35.23839  ? 1196 LYS   B CE   1 
ATOM   3309 N  NZ   . LYS   B 2 144 ? -23.30445 -36.80059 -15.01310 1.000 46.42204  ? 1196 LYS   B NZ   1 
ATOM   3310 N  N    . GLY   B 2 145 ? -17.50765 -37.38736 -19.39426 1.000 25.32389  ? 1197 GLY   B N    1 
ATOM   3311 C  CA   . GLY   B 2 145 ? -16.71973 -38.58540 -19.19219 1.000 26.04354  ? 1197 GLY   B CA   1 
ATOM   3312 C  C    . GLY   B 2 145 ? -16.85984 -39.52048 -20.37111 1.000 30.08492  ? 1197 GLY   B C    1 
ATOM   3313 O  O    . GLY   B 2 145 ? -16.59785 -39.12059 -21.50815 1.000 30.20135  ? 1197 GLY   B O    1 
ATOM   3314 N  N    . ASP   B 2 146 ? -17.30792 -40.75443 -20.11400 1.000 32.60804  ? 1198 ASP   B N    1 
ATOM   3315 C  CA   . ASP   B 2 146 ? -17.46403 -41.79650 -21.11891 1.000 27.22902  ? 1198 ASP   B CA   1 
ATOM   3316 C  C    . ASP   B 2 146 ? -18.74205 -41.66447 -21.92488 1.000 26.23010  ? 1198 ASP   B C    1 
ATOM   3317 O  O    . ASP   B 2 146 ? -18.94914 -42.45853 -22.85480 1.000 33.64612  ? 1198 ASP   B O    1 
ATOM   3318 C  CB   . ASP   B 2 146 ? -17.49011 -43.18345 -20.46080 1.000 33.85829  ? 1198 ASP   B CB   1 
ATOM   3319 C  CG   . ASP   B 2 146 ? -16.20411 -43.54448 -19.75682 1.000 38.53164  ? 1198 ASP   B CG   1 
ATOM   3320 O  OD1  . ASP   B 2 146 ? -15.14707 -42.92358 -20.03090 1.000 35.37258  ? 1198 ASP   B OD1  1 
ATOM   3321 O  OD2  . ASP   B 2 146 ? -16.25515 -44.49841 -18.94374 1.000 44.63229  ? 1198 ASP   B OD2  1 
ATOM   3322 N  N    . ILE   B 2 147 ? -19.60497 -40.71438 -21.60192 1.000 23.22322  ? 1199 ILE   B N    1 
ATOM   3323 C  CA   . ILE   B 2 147 ? -20.97399 -40.68532 -22.11487 1.000 27.57021  ? 1199 ILE   B CA   1 
ATOM   3324 C  C    . ILE   B 2 147 ? -21.14094 -39.53739 -23.09696 1.000 28.86783  ? 1199 ILE   B C    1 
ATOM   3325 O  O    . ILE   B 2 147 ? -20.65685 -38.42241 -22.85206 1.000 30.63646  ? 1199 ILE   B O    1 
ATOM   3326 C  CB   . ILE   B 2 147 ? -21.98693 -40.54216 -20.96485 1.000 27.54890  ? 1199 ILE   B CB   1 
ATOM   3327 C  CG1  . ILE   B 2 147 ? -21.76398 -41.65009 -19.93377 1.000 28.08167  ? 1199 ILE   B CG1  1 
ATOM   3328 C  CG2  . ILE   B 2 147 ? -23.40495 -40.51610 -21.52280 1.000 25.90914  ? 1199 ILE   B CG2  1 
ATOM   3329 C  CD1  . ILE   B 2 147 ? -22.38691 -41.36594 -18.60977 1.000 35.82578  ? 1199 ILE   B CD1  1 
ATOM   3330 N  N    . ALA   B 2 148 ? -21.85999 -39.79642 -24.18891 1.000 20.73835  ? 1200 ALA   B N    1 
ATOM   3331 C  CA   . ALA   B 2 148 ? -22.18396 -38.78648 -25.18098 1.000 26.22622  ? 1200 ALA   B CA   1 
ATOM   3332 C  C    . ALA   B 2 148 ? -23.65193 -38.40636 -25.07396 1.000 27.95147  ? 1200 ALA   B C    1 
ATOM   3333 O  O    . ALA   B 2 148 ? -24.51398 -39.26829 -24.88486 1.000 31.12313  ? 1200 ALA   B O    1 
ATOM   3334 C  CB   . ALA   B 2 148 ? -21.88804 -39.27961 -26.59995 1.000 24.74040  ? 1200 ALA   B CB   1 
ATOM   3335 N  N    . HIS   B 2 149 ? -23.92884 -37.11836 -25.21605 1.000 27.86188  ? 1201 HIS   B N    1 
ATOM   3336 C  CA   . HIS   B 2 149 ? -25.28680 -36.59426 -25.24604 1.000 28.77241  ? 1201 HIS   B CA   1 
ATOM   3337 C  C    . HIS   B 2 149 ? -25.47479 -35.81435 -26.53310 1.000 24.31858  ? 1201 HIS   B C    1 
ATOM   3338 O  O    . HIS   B 2 149 ? -24.61375 -35.00944 -26.90719 1.000 26.60016  ? 1201 HIS   B O    1 
ATOM   3339 C  CB   . HIS   B 2 149 ? -25.56269 -35.68415 -24.04710 1.000 28.43872  ? 1201 HIS   B CB   1 
ATOM   3340 C  CG   . HIS   B 2 149 ? -25.34169 -36.34206 -22.72306 1.000 27.66929  ? 1201 HIS   B CG   1 
ATOM   3341 N  ND1  . HIS   B 2 149 ? -24.50162 -35.81604 -21.76813 1.000 29.00667  ? 1201 HIS   B ND1  1 
ATOM   3342 C  CD2  . HIS   B 2 149 ? -25.87475 -37.46197 -22.17795 1.000 30.12505  ? 1201 HIS   B CD2  1 
ATOM   3343 C  CE1  . HIS   B 2 149 ? -24.51764 -36.58596 -20.69507 1.000 31.76218  ? 1201 HIS   B CE1  1 
ATOM   3344 N  NE2  . HIS   B 2 149 ? -25.34272 -37.59291 -20.91596 1.000 29.66484  ? 1201 HIS   B NE2  1 
ATOM   3345 N  N    . ILE   B 2 150 ? -26.58283 -36.05932 -27.21704 1.000 23.85115  ? 1202 ILE   B N    1 
ATOM   3346 C  CA   . ILE   B 2 150 ? -26.92282 -35.33039 -28.43008 1.000 27.04585  ? 1202 ILE   B CA   1 
ATOM   3347 C  C    . ILE   B 2 150 ? -28.14375 -34.48028 -28.13211 1.000 29.21086  ? 1202 ILE   B C    1 
ATOM   3348 O  O    . ILE   B 2 150 ? -29.14877 -34.99917 -27.63403 1.000 31.41814  ? 1202 ILE   B O    1 
ATOM   3349 C  CB   . ILE   B 2 150 ? -27.16493 -36.28747 -29.60800 1.000 28.19318  ? 1202 ILE   B CB   1 
ATOM   3350 C  CG1  . ILE   B 2 150 ? -25.84800 -36.98959 -29.97599 1.000 25.99183  ? 1202 ILE   B CG1  1 
ATOM   3351 C  CG2  . ILE   B 2 150 ? -27.72892 -35.53052 -30.82704 1.000 29.66905  ? 1202 ILE   B CG2  1 
ATOM   3352 C  CD1  . ILE   B 2 150 ? -25.99711 -38.03467 -31.05490 1.000 31.93078  ? 1202 ILE   B CD1  1 
ATOM   3353 N  N    . TYR   B 2 151 ? -28.04967 -33.18231 -28.42521 1.000 26.55063  ? 1203 TYR   B N    1 
ATOM   3354 C  CA   . TYR   B 2 151 ? -29.09359 -32.21821 -28.12425 1.000 31.71388  ? 1203 TYR   B CA   1 
ATOM   3355 C  C    . TYR   B 2 151 ? -29.62459 -31.57127 -29.39029 1.000 29.32014  ? 1203 TYR   B C    1 
ATOM   3356 O  O    . TYR   B 2 151 ? -28.89761 -31.38440 -30.37133 1.000 28.58630  ? 1203 TYR   B O    1 
ATOM   3357 C  CB   . TYR   B 2 151 ? -28.58947 -31.08718 -27.20336 1.000 28.75980  ? 1203 TYR   B CB   1 
ATOM   3358 C  CG   . TYR   B 2 151 ? -28.00446 -31.56312 -25.90934 1.000 29.38924  ? 1203 TYR   B CG   1 
ATOM   3359 C  CD1  . TYR   B 2 151 ? -28.80643 -31.73097 -24.78230 1.000 28.70054  ? 1203 TYR   B CD1  1 
ATOM   3360 C  CD2  . TYR   B 2 151 ? -26.64948 -31.85321 -25.81337 1.000 28.89670  ? 1203 TYR   B CD2  1 
ATOM   3361 C  CE1  . TYR   B 2 151 ? -28.27442 -32.16591 -23.60729 1.000 28.81877  ? 1203 TYR   B CE1  1 
ATOM   3362 C  CE2  . TYR   B 2 151 ? -26.09847 -32.30715 -24.62235 1.000 26.02344  ? 1203 TYR   B CE2  1 
ATOM   3363 C  CZ   . TYR   B 2 151 ? -26.90944 -32.44701 -23.52731 1.000 25.17888  ? 1203 TYR   B CZ   1 
ATOM   3364 O  OH   . TYR   B 2 151 ? -26.38643 -32.88895 -22.34930 1.000 27.61395  ? 1203 TYR   B OH   1 
ATOM   3365 N  N    . ASP   B 2 152 ? -30.88955 -31.16818 -29.32827 1.000 32.65687  ? 1204 ASP   B N    1 
ATOM   3366 C  CA   . ASP   B 2 152 ? -31.48253 -30.35022 -30.37732 1.000 34.48249  ? 1204 ASP   B CA   1 
ATOM   3367 C  C    . ASP   B 2 152 ? -31.16342 -28.87922 -30.13644 1.000 36.34260  ? 1204 ASP   B C    1 
ATOM   3368 O  O    . ASP   B 2 152 ? -31.34134 -28.36412 -29.02548 1.000 33.31034  ? 1204 ASP   B O    1 
ATOM   3369 C  CB   . ASP   B 2 152 ? -32.99155 -30.55411 -30.43225 1.000 34.57770  ? 1204 ASP   B CB   1 
ATOM   3370 C  CG   . ASP   B 2 152 ? -33.62454 -29.82816 -31.59328 1.000 38.24659  ? 1204 ASP   B CG   1 
ATOM   3371 O  OD1  . ASP   B 2 152 ? -33.33461 -30.19327 -32.75126 1.000 43.47055  ? 1204 ASP   B OD1  1 
ATOM   3372 O  OD2  . ASP   B 2 152 ? -34.39546 -28.88208 -31.34333 1.000 44.94162  ? 1204 ASP   B OD2  1 
ATOM   3373 N  N    . ILE   B 2 153 ? -30.70540 -28.19334 -31.18051 1.000 30.79648  ? 1205 ILE   B N    1 
ATOM   3374 C  CA   . ILE   B 2 153 ? -30.28330 -26.81135 -30.98364 1.000 36.38836  ? 1205 ILE   B CA   1 
ATOM   3375 C  C    . ILE   B 2 153 ? -31.47122 -25.92824 -30.63167 1.000 38.41226  ? 1205 ILE   B C    1 
ATOM   3376 O  O    . ILE   B 2 153 ? -31.35713 -25.02218 -29.79674 1.000 35.31120  ? 1205 ILE   B O    1 
ATOM   3377 C  CB   . ILE   B 2 153 ? -29.54030 -26.28450 -32.22171 1.000 34.89978  ? 1205 ILE   B CB   1 
ATOM   3378 C  CG1  . ILE   B 2 153 ? -28.06333 -26.64260 -32.14073 1.000 32.05870  ? 1205 ILE   B CG1  1 
ATOM   3379 C  CG2  . ILE   B 2 153 ? -29.72220 -24.78350 -32.35982 1.000 36.59375  ? 1205 ILE   B CG2  1 
ATOM   3380 C  CD1  . ILE   B 2 153 ? -27.26333 -26.10475 -33.27880 1.000 30.91306  ? 1205 ILE   B CD1  1 
ATOM   3381 N  N    . GLN   B 2 154 ? -32.62526 -26.15821 -31.26761 1.000 37.53592  ? 1206 GLN   B N    1 
ATOM   3382 C  CA   . GLN   B 2 154 ? -33.74219 -25.24011 -31.06864 1.000 42.95472  ? 1206 GLN   B CA   1 
ATOM   3383 C  C    . GLN   B 2 154 ? -34.40015 -25.43695 -29.70960 1.000 37.49984  ? 1206 GLN   B C    1 
ATOM   3384 O  O    . GLN   B 2 154 ? -34.58906 -24.47088 -28.96367 1.000 38.94989  ? 1206 GLN   B O    1 
ATOM   3385 C  CB   . GLN   B 2 154 ? -34.77224 -25.38812 -32.19959 1.000 38.80572  ? 1206 GLN   B CB   1 
ATOM   3386 C  CG   . GLN   B 2 154 ? -34.36823 -24.66426 -33.49566 1.000 52.11141  ? 1206 GLN   B CG   1 
ATOM   3387 C  CD   . GLN   B 2 154 ? -33.76112 -23.26728 -33.25479 1.000 58.82926  ? 1206 GLN   B CD   1 
ATOM   3388 O  OE1  . GLN   B 2 154 ? -32.66612 -22.96440 -33.75386 1.000 58.24210  ? 1206 GLN   B OE1  1 
ATOM   3389 N  NE2  . GLN   B 2 154 ? -34.47103 -22.41417 -32.49684 1.000 58.41715  ? 1206 GLN   B NE2  1 
ATOM   3390 N  N    . THR   B 2 155 ? -34.73723 -26.67490 -29.36049 1.000 33.08838  ? 1207 THR   B N    1 
ATOM   3391 C  CA   . THR   B 2 155 ? -35.34520 -26.93876 -28.06445 1.000 37.36519  ? 1207 THR   B CA   1 
ATOM   3392 C  C    . THR   B 2 155 ? -34.33618 -27.11474 -26.93547 1.000 38.24472  ? 1207 THR   B C    1 
ATOM   3393 O  O    . THR   B 2 155 ? -34.70612 -26.93462 -25.76247 1.000 36.25974  ? 1207 THR   B O    1 
ATOM   3394 C  CB   . THR   B 2 155 ? -36.23030 -28.19270 -28.12832 1.000 37.26853  ? 1207 THR   B CB   1 
ATOM   3395 O  OG1  . THR   B 2 155 ? -35.41639 -29.34078 -28.37826 1.000 37.58196  ? 1207 THR   B OG1  1 
ATOM   3396 C  CG2  . THR   B 2 155 ? -37.26733 -28.06071 -29.23829 1.000 38.20485  ? 1207 THR   B CG2  1 
ATOM   3397 N  N    . GLY   B 2 156 ? -33.07821 -27.43786 -27.25349 1.000 34.42363  ? 1208 GLY   B N    1 
ATOM   3398 C  CA   . GLY   B 2 156 ? -32.12820 -27.83684 -26.24549 1.000 32.03728  ? 1208 GLY   B CA   1 
ATOM   3399 C  C    . GLY   B 2 156 ? -32.38428 -29.19878 -25.64037 1.000 35.73231  ? 1208 GLY   B C    1 
ATOM   3400 O  O    . GLY   B 2 156 ? -31.63128 -29.61476 -24.75237 1.000 33.14782  ? 1208 GLY   B O    1 
ATOM   3401 N  N    . ASN   B 2 157 ? -33.42035 -29.90674 -26.08628 1.000 36.29284  ? 1209 ASN   B N    1 
ATOM   3402 C  CA   . ASN   B 2 157 ? -33.74042 -31.21667 -25.53217 1.000 33.88004  ? 1209 ASN   B CA   1 
ATOM   3403 C  C    . ASN   B 2 157 ? -32.64251 -32.22078 -25.84213 1.000 29.31357  ? 1209 ASN   B C    1 
ATOM   3404 O  O    . ASN   B 2 157 ? -32.07555 -32.22890 -26.93615 1.000 30.80890  ? 1209 ASN   B O    1 
ATOM   3405 C  CB   . ASN   B 2 157 ? -35.06348 -31.74262 -26.10408 1.000 37.03668  ? 1209 ASN   B CB   1 
ATOM   3406 C  CG   . ASN   B 2 157 ? -36.25540 -30.84651 -25.78211 1.000 41.48587  ? 1209 ASN   B CG   1 
ATOM   3407 O  OD1  . ASN   B 2 157 ? -36.15631 -29.89045 -25.00219 1.000 41.25950  ? 1209 ASN   B OD1  1 
ATOM   3408 N  ND2  . ASN   B 2 157 ? -37.39445 -31.16047 -26.38304 1.000 44.14577  ? 1209 ASN   B ND2  1 
ATOM   3409 N  N    . LYS   B 2 158 ? -32.34553 -33.07072 -24.87007 1.000 31.01689  ? 1210 LYS   B N    1 
ATOM   3410 C  CA   . LYS   B 2 158 ? -31.48962 -34.21680 -25.10901 1.000 32.54757  ? 1210 LYS   B CA   1 
ATOM   3411 C  C    . LYS   B 2 158 ? -32.23273 -35.20782 -25.99990 1.000 35.57918  ? 1210 LYS   B C    1 
ATOM   3412 O  O    . LYS   B 2 158 ? -33.25975 -35.75971 -25.59782 1.000 35.29466  ? 1210 LYS   B O    1 
ATOM   3413 C  CB   . LYS   B 2 158 ? -31.09262 -34.86572 -23.78897 1.000 33.68796  ? 1210 LYS   B CB   1 
ATOM   3414 C  CG   . LYS   B 2 158 ? -30.19572 -36.06481 -23.99091 1.000 33.84493  ? 1210 LYS   B CG   1 
ATOM   3415 C  CD   . LYS   B 2 158 ? -29.36369 -36.34777 -22.77592 1.000 31.89876  ? 1210 LYS   B CD   1 
ATOM   3416 C  CE   . LYS   B 2 158 ? -30.21367 -36.62261 -21.55686 1.000 42.49469  ? 1210 LYS   B CE   1 
ATOM   3417 N  NZ   . LYS   B 2 158 ? -29.36063 -36.70958 -20.32789 1.000 45.44022  ? 1210 LYS   B NZ   1 
ATOM   3418 N  N    . LEU   B 2 159 ? -31.72879 -35.41295 -27.21591 1.000 33.86271  ? 1211 LEU   B N    1 
ATOM   3419 C  CA   . LEU   B 2 159 ? -32.33089 -36.35398 -28.15681 1.000 34.55309  ? 1211 LEU   B CA   1 
ATOM   3420 C  C    . LEU   B 2 159 ? -31.85098 -37.77299 -27.88972 1.000 36.18511  ? 1211 LEU   B C    1 
ATOM   3421 O  O    . LEU   B 2 159 ? -32.62705 -38.72795 -28.00061 1.000 41.82162  ? 1211 LEU   B O    1 
ATOM   3422 C  CB   . LEU   B 2 159 ? -31.98891 -35.95112 -29.59685 1.000 31.31679  ? 1211 LEU   B CB   1 
ATOM   3423 C  CG   . LEU   B 2 159 ? -32.42283 -34.56112 -30.05895 1.000 37.27522  ? 1211 LEU   B CG   1 
ATOM   3424 C  CD1  . LEU   B 2 159 ? -32.04186 -34.30427 -31.50598 1.000 32.21861  ? 1211 LEU   B CD1  1 
ATOM   3425 C  CD2  . LEU   B 2 159 ? -33.92081 -34.39100 -29.86491 1.000 34.43768  ? 1211 LEU   B CD2  1 
ATOM   3426 N  N    . LEU   B 2 160 ? -30.58398 -37.93006 -27.52575 1.000 36.83119  ? 1212 LEU   B N    1 
ATOM   3427 C  CA   . LEU   B 2 160 ? -29.98807 -39.25009 -27.39966 1.000 34.34409  ? 1212 LEU   B CA   1 
ATOM   3428 C  C    . LEU   B 2 160 ? -28.88703 -39.22609 -26.35871 1.000 31.75640  ? 1212 LEU   B C    1 
ATOM   3429 O  O    . LEU   B 2 160 ? -28.13396 -38.25713 -26.26781 1.000 32.48951  ? 1212 LEU   B O    1 
ATOM   3430 C  CB   . LEU   B 2 160 ? -29.40015 -39.70324 -28.73265 1.000 33.50889  ? 1212 LEU   B CB   1 
ATOM   3431 C  CG   . LEU   B 2 160 ? -30.21825 -40.66525 -29.56754 1.000 42.88294  ? 1212 LEU   B CG   1 
ATOM   3432 C  CD1  . LEU   B 2 160 ? -29.61130 -40.70540 -30.95156 1.000 46.73630  ? 1212 LEU   B CD1  1 
ATOM   3433 C  CD2  . LEU   B 2 160 ? -30.16832 -42.03520 -28.90044 1.000 46.17415  ? 1212 LEU   B CD2  1 
ATOM   3434 N  N    . THR   B 2 161 ? -28.78708 -40.30903 -25.59962 1.000 30.22897  ? 1213 THR   B N    1 
ATOM   3435 C  CA   . THR   B 2 161 ? -27.60208 -40.61706 -24.82264 1.000 32.29236  ? 1213 THR   B CA   1 
ATOM   3436 C  C    . THR   B 2 161 ? -26.98219 -41.85515 -25.43657 1.000 32.58733  ? 1213 THR   B C    1 
ATOM   3437 O  O    . THR   B 2 161 ? -27.69827 -42.80113 -25.76347 1.000 34.75618  ? 1213 THR   B O    1 
ATOM   3438 C  CB   . THR   B 2 161 ? -27.94004 -40.86192 -23.35261 1.000 31.02777  ? 1213 THR   B CB   1 
ATOM   3439 O  OG1  . THR   B 2 161 ? -28.48493 -39.66383 -22.77969 1.000 36.10019  ? 1213 THR   B OG1  1 
ATOM   3440 C  CG2  . THR   B 2 161 ? -26.69905 -41.28595 -22.58562 1.000 29.97906  ? 1213 THR   B CG2  1 
ATOM   3441 N  N    . LEU   B 2 162 ? -25.66419 -41.84626 -25.61061 1.000 31.24224  ? 1214 LEU   B N    1 
ATOM   3442 C  CA   . LEU   B 2 162 ? -24.94530 -42.97236 -26.19855 1.000 31.67962  ? 1214 LEU   B CA   1 
ATOM   3443 C  C    . LEU   B 2 162 ? -23.89929 -43.42236 -25.19855 1.000 31.56176  ? 1214 LEU   B C    1 
ATOM   3444 O  O    . LEU   B 2 162 ? -22.94723 -42.69040 -24.90864 1.000 32.94501  ? 1214 LEU   B O    1 
ATOM   3445 C  CB   . LEU   B 2 162 ? -24.29132 -42.61651 -27.53160 1.000 31.58439  ? 1214 LEU   B CB   1 
ATOM   3446 C  CG   . LEU   B 2 162 ? -25.14031 -41.96754 -28.62162 1.000 37.25915  ? 1214 LEU   B CG   1 
ATOM   3447 C  CD1  . LEU   B 2 162 ? -24.26533 -41.64270 -29.82168 1.000 28.87212  ? 1214 LEU   B CD1  1 
ATOM   3448 C  CD2  . LEU   B 2 162 ? -26.31239 -42.85748 -29.02351 1.000 35.43839  ? 1214 LEU   B CD2  1 
ATOM   3449 N  N    . PHE   B 2 163 ? -24.05636 -44.63731 -24.69645 1.000 31.10200  ? 1215 PHE   B N    1 
ATOM   3450 C  CA   . PHE   B 2 163 ? -23.09237 -45.20130 -23.77344 1.000 31.57753  ? 1215 PHE   B CA   1 
ATOM   3451 C  C    . PHE   B 2 163 ? -23.40347 -46.68027 -23.64231 1.000 36.51134  ? 1215 PHE   B C    1 
ATOM   3452 O  O    . PHE   B 2 163 ? -24.57150 -47.07219 -23.64424 1.000 37.35206  ? 1215 PHE   B O    1 
ATOM   3453 C  CB   . PHE   B 2 163 ? -23.16127 -44.51919 -22.40649 1.000 31.80054  ? 1215 PHE   B CB   1 
ATOM   3454 C  CG   . PHE   B 2 163 ? -22.39029 -45.24116 -21.34846 1.000 34.72608  ? 1215 PHE   B CG   1 
ATOM   3455 C  CD1  . PHE   B 2 163 ? -21.00928 -45.18326 -21.32252 1.000 30.61403  ? 1215 PHE   B CD1  1 
ATOM   3456 C  CD2  . PHE   B 2 163 ? -23.04131 -45.99404 -20.39338 1.000 37.84556  ? 1215 PHE   B CD2  1 
ATOM   3457 C  CE1  . PHE   B 2 163 ? -20.29130 -45.85423 -20.36149 1.000 33.22200  ? 1215 PHE   B CE1  1 
ATOM   3458 C  CE2  . PHE   B 2 163 ? -22.32632 -46.67301 -19.42735 1.000 36.71865  ? 1215 PHE   B CE2  1 
ATOM   3459 C  CZ   . PHE   B 2 163 ? -20.95232 -46.60811 -19.41140 1.000 37.07306  ? 1215 PHE   B CZ   1 
ATOM   3460 N  N    . ASN   B 2 164 ? -22.36953 -47.47834 -23.55129 1.000 37.35539  ? 1216 ASN   B N    1 
ATOM   3461 C  CA   . ASN   B 2 164 ? -22.48363 -48.91932 -23.40917 1.000 36.71604  ? 1216 ASN   B CA   1 
ATOM   3462 C  C    . ASN   B 2 164 ? -21.31363 -49.38133 -22.55917 1.000 34.96944  ? 1216 ASN   B C    1 
ATOM   3463 O  O    . ASN   B 2 164 ? -20.18065 -49.40946 -23.04821 1.000 34.16337  ? 1216 ASN   B O    1 
ATOM   3464 C  CB   . ASN   B 2 164 ? -22.46873 -49.60543 -24.77211 1.000 40.16597  ? 1216 ASN   B CB   1 
ATOM   3465 C  CG   . ASN   B 2 164 ? -22.68683 -51.10540 -24.66599 1.000 45.39548  ? 1216 ASN   B CG   1 
ATOM   3466 O  OD1  . ASN   B 2 164 ? -22.24084 -51.74736 -23.70995 1.000 46.91746  ? 1216 ASN   B OD1  1 
ATOM   3467 N  ND2  . ASN   B 2 164 ? -23.38991 -51.66643 -25.64392 1.000 47.18330  ? 1216 ASN   B ND2  1 
ATOM   3468 N  N    . PRO   B 2 165 ? -21.54261 -49.73322 -21.28814 1.000 39.05789  ? 1217 PRO   B N    1 
ATOM   3469 C  CA   . PRO   B 2 165 ? -20.41460 -49.98423 -20.38316 1.000 37.26796  ? 1217 PRO   B CA   1 
ATOM   3470 C  C    . PRO   B 2 165 ? -19.60870 -51.21031 -20.74809 1.000 42.25038  ? 1217 PRO   B C    1 
ATOM   3471 O  O    . PRO   B 2 165 ? -18.44269 -51.29337 -20.35112 1.000 45.77468  ? 1217 PRO   B O    1 
ATOM   3472 C  CB   . PRO   B 2 165 ? -21.08956 -50.14007 -19.01412 1.000 41.05950  ? 1217 PRO   B CB   1 
ATOM   3473 C  CG   . PRO   B 2 165 ? -22.45660 -50.61000 -19.33203 1.000 40.81930  ? 1217 PRO   B CG   1 
ATOM   3474 C  CD   . PRO   B 2 165 ? -22.83960 -49.93307 -20.62007 1.000 41.34736  ? 1217 PRO   B CD   1 
ATOM   3475 N  N    . ASP   B 2 166 ? -20.18079 -52.15333 -21.49799 1.000 39.44803  ? 1218 ASP   B N    1 
ATOM   3476 C  CA   . ASP   B 2 166 ? -19.40189 -53.29343 -21.95893 1.000 38.78902  ? 1218 ASP   B CA   1 
ATOM   3477 C  C    . ASP   B 2 166 ? -18.42190 -52.90158 -23.05500 1.000 41.54577  ? 1218 ASP   B C    1 
ATOM   3478 O  O    . ASP   B 2 166 ? -17.32895 -53.47467 -23.13699 1.000 45.03657  ? 1218 ASP   B O    1 
ATOM   3479 C  CB   . ASP   B 2 166 ? -20.33499 -54.39440 -22.45481 1.000 45.36641  ? 1218 ASP   B CB   1 
ATOM   3480 C  CG   . ASP   B 2 166 ? -21.21299 -54.94425 -21.35174 1.000 52.28973  ? 1218 ASP   B CG   1 
ATOM   3481 O  OD1  . ASP   B 2 166 ? -20.77894 -54.88719 -20.17676 1.000 51.95390  ? 1218 ASP   B OD1  1 
ATOM   3482 O  OD2  . ASP   B 2 166 ? -22.33203 -55.42019 -21.65466 1.000 58.15444  ? 1218 ASP   B OD2  1 
ATOM   3483 N  N    . LEU   B 2 167 ? -18.78386 -51.92862 -23.89306 1.000 36.95295  ? 1219 LEU   B N    1 
ATOM   3484 C  CA   . LEU   B 2 167 ? -17.92187 -51.48577 -24.98413 1.000 38.62787  ? 1219 LEU   B CA   1 
ATOM   3485 C  C    . LEU   B 2 167 ? -17.02677 -50.30881 -24.61725 1.000 40.19183  ? 1219 LEU   B C    1 
ATOM   3486 O  O    . LEU   B 2 167 ? -16.16977 -49.93493 -25.42031 1.000 39.83789  ? 1219 LEU   B O    1 
ATOM   3487 C  CB   . LEU   B 2 167 ? -18.76988 -51.09481 -26.19813 1.000 37.73260  ? 1219 LEU   B CB   1 
ATOM   3488 C  CG   . LEU   B 2 167 ? -19.66298 -52.19979 -26.74501 1.000 39.60980  ? 1219 LEU   B CG   1 
ATOM   3489 C  CD1  . LEU   B 2 167 ? -20.44299 -51.69282 -27.93002 1.000 40.77837  ? 1219 LEU   B CD1  1 
ATOM   3490 C  CD2  . LEU   B 2 167 ? -18.80308 -53.37688 -27.13395 1.000 39.89099  ? 1219 LEU   B CD2  1 
ATOM   3491 N  N    . ALA   B 2 168 ? -17.20269 -49.70770 -23.44629 1.000 43.22113  ? 1220 ALA   B N    1 
ATOM   3492 C  CA   . ALA   B 2 168 ? -16.46459 -48.49573 -23.11542 1.000 34.41898  ? 1220 ALA   B CA   1 
ATOM   3493 C  C    . ALA   B 2 168 ? -14.96360 -48.75084 -23.11445 1.000 36.95487  ? 1220 ALA   B C    1 
ATOM   3494 O  O    . ALA   B 2 168 ? -14.49366 -49.80084 -22.66438 1.000 35.91938  ? 1220 ALA   B O    1 
ATOM   3495 C  CB   . ALA   B 2 168 ? -16.89950 -47.96859 -21.74444 1.000 30.68334  ? 1220 ALA   B CB   1 
ATOM   3496 N  N    . ASN   B 2 169 ? -14.20455 -47.76493 -23.60455 1.000 27.94096  ? 1221 ASN   B N    1 
ATOM   3497 C  CA   . ASN   B 2 169 ? -12.76054 -47.76102 -23.43861 1.000 31.12859  ? 1221 ASN   B CA   1 
ATOM   3498 C  C    . ASN   B 2 169 ? -12.29944 -46.88597 -22.28369 1.000 28.67281  ? 1221 ASN   B C    1 
ATOM   3499 O  O    . ASN   B 2 169 ? -11.12843 -46.95702 -21.90373 1.000 28.85649  ? 1221 ASN   B O    1 
ATOM   3500 C  CB   . ASN   B 2 169 ? -12.07156 -47.30418 -24.73167 1.000 31.11276  ? 1221 ASN   B CB   1 
ATOM   3501 C  CG   . ASN   B 2 169 ? -12.13267 -48.35126 -25.81358 1.000 30.32080  ? 1221 ASN   B CG   1 
ATOM   3502 O  OD1  . ASN   B 2 169 ? -11.59274 -49.44028 -25.64851 1.000 32.85146  ? 1221 ASN   B OD1  1 
ATOM   3503 N  ND2  . ASN   B 2 169 ? -12.79969 -48.03930 -26.92458 1.000 33.79896  ? 1221 ASN   B ND2  1 
ATOM   3504 N  N    . ASN   B 2 170 ? -13.17936 -46.05586 -21.72173 1.000 29.73964  ? 1222 ASN   B N    1 
ATOM   3505 C  CA   . ASN   B 2 170 ? -12.83026 -45.22779 -20.57180 1.000 29.01423  ? 1222 ASN   B CA   1 
ATOM   3506 C  C    . ASN   B 2 170 ? -11.66820 -44.29290 -20.88392 1.000 31.62155  ? 1222 ASN   B C    1 
ATOM   3507 O  O    . ASN   B 2 170 ? -10.77716 -44.09790 -20.05697 1.000 30.81740  ? 1222 ASN   B O    1 
ATOM   3508 C  CB   . ASN   B 2 170 ? -12.49128 -46.09072 -19.35075 1.000 34.53034  ? 1222 ASN   B CB   1 
ATOM   3509 C  CG   . ASN   B 2 170 ? -13.52335 -47.17363 -19.10563 1.000 36.15180  ? 1222 ASN   B CG   1 
ATOM   3510 O  OD1  . ASN   B 2 170 ? -13.22244 -48.37165 -19.17554 1.000 40.47472  ? 1222 ASN   B OD1  1 
ATOM   3511 N  ND2  . ASN   B 2 170 ? -14.74831 -46.76051 -18.82761 1.000 36.58338  ? 1222 ASN   B ND2  1 
ATOM   3512 N  N    . TYR   B 2 171 ? -11.66020 -43.71400 -22.08597 1.000 25.84923  ? 1223 TYR   B N    1 
ATOM   3513 C  CA   . TYR   B 2 171 ? -10.58915 -42.78410 -22.41608 1.000 27.63749  ? 1223 TYR   B CA   1 
ATOM   3514 C  C    . TYR   B 2 171 ? -10.63803 -41.57002 -21.48717 1.000 27.78136  ? 1223 TYR   B C    1 
ATOM   3515 O  O    . TYR   B 2 171 ? -11.70298 -40.99593 -21.24818 1.000 28.09637  ? 1223 TYR   B O    1 
ATOM   3516 C  CB   . TYR   B 2 171 ? -10.69817 -42.33921 -23.87911 1.000 28.37220  ? 1223 TYR   B CB   1 
ATOM   3517 C  CG   . TYR   B 2 171 ? -10.22128 -43.36932 -24.89604 1.000 26.68792  ? 1223 TYR   B CG   1 
ATOM   3518 C  CD1  . TYR   B 2 171 ? -8.91031  -43.82942 -24.88505 1.000 26.52462  ? 1223 TYR   B CD1  1 
ATOM   3519 C  CD2  . TYR   B 2 171 ? -11.07235 -43.83834 -25.88698 1.000 28.21847  ? 1223 TYR   B CD2  1 
ATOM   3520 C  CE1  . TYR   B 2 171 ? -8.45741  -44.75352 -25.83300 1.000 27.55613  ? 1223 TYR   B CE1  1 
ATOM   3521 C  CE2  . TYR   B 2 171 ? -10.63145 -44.77645 -26.84192 1.000 27.58556  ? 1223 TYR   B CE2  1 
ATOM   3522 C  CZ   . TYR   B 2 171 ? -9.32148  -45.21954 -26.80993 1.000 27.59468  ? 1223 TYR   B CZ   1 
ATOM   3523 O  OH   . TYR   B 2 171 ? -8.86658  -46.13165 -27.75687 1.000 32.38408  ? 1223 TYR   B OH   1 
ATOM   3524 N  N    . LYS   B 2 172 ? -9.47698  -41.16407 -20.97525 1.000 26.51541  ? 1224 LYS   B N    1 
ATOM   3525 C  CA   . LYS   B 2 172 ? -9.47887  -40.12598 -19.95233 1.000 31.90450  ? 1224 LYS   B CA   1 
ATOM   3526 C  C    . LYS   B 2 172 ? -9.81679  -38.76501 -20.53042 1.000 33.51740  ? 1224 LYS   B C    1 
ATOM   3527 O  O    . LYS   B 2 172 ? -10.39770 -37.93791 -19.82747 1.000 29.62321  ? 1224 LYS   B O    1 
ATOM   3528 C  CB   . LYS   B 2 172 ? -8.13884  -40.07002 -19.22438 1.000 28.63274  ? 1224 LYS   B CB   1 
ATOM   3529 C  CG   . LYS   B 2 172 ? -7.85490  -41.29198 -18.37129 1.000 34.93472  ? 1224 LYS   B CG   1 
ATOM   3530 C  CD   . LYS   B 2 172 ? -6.62385  -41.07300 -17.48635 1.000 39.21302  ? 1224 LYS   B CD   1 
ATOM   3531 C  CE   . LYS   B 2 172 ? -6.17392  -42.37798 -16.86227 1.000 44.54010  ? 1224 LYS   B CE   1 
ATOM   3532 N  NZ   . LYS   B 2 172 ? -4.99387  -42.16999 -15.97833 1.000 52.36770  ? 1224 LYS   B NZ   1 
ATOM   3533 N  N    . ARG   B 2 173 ? -9.49082  -38.51213 -21.79945 1.000 25.41987  ? 1225 ARG   B N    1 
ATOM   3534 C  CA   . ARG   B 2 173 ? -9.85575  -37.25715 -22.44654 1.000 25.14891  ? 1225 ARG   B CA   1 
ATOM   3535 C  C    . ARG   B 2 173 ? -10.86881 -37.49117 -23.55849 1.000 29.63067  ? 1225 ARG   B C    1 
ATOM   3536 O  O    . ARG   B 2 173 ? -10.81480 -36.85426 -24.61154 1.000 24.59424  ? 1225 ARG   B O    1 
ATOM   3537 C  CB   . ARG   B 2 173 ? -8.62772  -36.54329 -23.00464 1.000 30.83851  ? 1225 ARG   B CB   1 
ATOM   3538 C  CG   . ARG   B 2 173 ? -7.47767  -36.42129 -22.02169 1.000 29.45470  ? 1225 ARG   B CG   1 
ATOM   3539 C  CD   . ARG   B 2 173 ? -7.76456  -35.37519 -20.97576 1.000 39.29461  ? 1225 ARG   B CD   1 
ATOM   3540 N  NE   . ARG   B 2 173 ? -8.09248  -34.05321 -21.51986 1.000 40.13876  ? 1225 ARG   B NE   1 
ATOM   3541 C  CZ   . ARG   B 2 173 ? -7.22942  -33.04928 -21.65497 1.000 42.99099  ? 1225 ARG   B CZ   1 
ATOM   3542 N  NH1  . ARG   B 2 173 ? -5.93142  -33.21336 -21.44100 1.000 39.95815  ? 1225 ARG   B NH1  1 
ATOM   3543 N  NH2  . ARG   B 2 173 ? -7.68434  -31.84328 -21.98805 1.000 31.97113  ? 1225 ARG   B NH2  1 
ATOM   3544 N  N    . ASN   B 2 174 ? -11.79286 -38.41909 -23.34238 1.000 24.13897  ? 1226 ASN   B N    1 
ATOM   3545 C  CA   . ASN   B 2 174 ? -12.79892 -38.72009 -24.34732 1.000 23.74795  ? 1226 ASN   B CA   1 
ATOM   3546 C  C    . ASN   B 2 174 ? -13.48785 -37.44208 -24.81540 1.000 29.26615  ? 1226 ASN   B C    1 
ATOM   3547 O  O    . ASN   B 2 174 ? -13.85276 -36.58799 -24.00845 1.000 27.57349  ? 1226 ASN   B O    1 
ATOM   3548 C  CB   . ASN   B 2 174 ? -13.82397 -39.69697 -23.77321 1.000 23.75885  ? 1226 ASN   B CB   1 
ATOM   3549 C  CG   . ASN   B 2 174 ? -14.95003 -39.97697 -24.74014 1.000 27.47925  ? 1226 ASN   B CG   1 
ATOM   3550 O  OD1  . ASN   B 2 174 ? -14.70209 -40.21708 -25.91213 1.000 27.41033  ? 1226 ASN   B OD1  1 
ATOM   3551 N  ND2  . ASN   B 2 174 ? -16.19701 -39.91184 -24.26510 1.000 25.96712  ? 1226 ASN   B ND2  1 
ATOM   3552 N  N    . CYS   B 2 175 ? -13.65888 -37.31517 -26.13040 1.000 23.78241  ? 1227 CYS   B N    1 
ATOM   3553 C  CA   . CYS   B 2 175 ? -14.48783 -36.27916 -26.74745 1.000 23.25761  ? 1227 CYS   B CA   1 
ATOM   3554 C  C    . CYS   B 2 175 ? -15.36792 -36.92118 -27.80737 1.000 26.12519  ? 1227 CYS   B C    1 
ATOM   3555 O  O    . CYS   B 2 175 ? -14.85699 -37.37530 -28.83135 1.000 27.21865  ? 1227 CYS   B O    1 
ATOM   3556 C  CB   . CYS   B 2 175 ? -13.64677 -35.17827 -27.39157 1.000 28.61942  ? 1227 CYS   B CB   1 
ATOM   3557 S  SG   . CYS   B 2 175 ? -12.86765 -34.08924 -26.22068 1.000 32.30370  ? 1227 CYS   B SG   1 
ATOM   3558 N  N    . ALA   B 2 176 ? -16.67891 -36.91307 -27.58532 1.000 23.83161  ? 1228 ALA   B N    1 
ATOM   3559 C  CA   . ALA   B 2 176 ? -17.62398 -37.40408 -28.57425 1.000 24.10376  ? 1228 ALA   B CA   1 
ATOM   3560 C  C    . ALA   B 2 176 ? -17.74095 -36.42816 -29.74133 1.000 24.92188  ? 1228 ALA   B C    1 
ATOM   3561 O  O    . ALA   B 2 176 ? -17.66885 -35.20515 -29.57742 1.000 25.00164  ? 1228 ALA   B O    1 
ATOM   3562 C  CB   . ALA   B 2 176 ? -18.99197 -37.63393 -27.93619 1.000 21.73502  ? 1228 ALA   B CB   1 
ATOM   3563 N  N    . THR   B 2 177 ? -17.95103 -36.97824 -30.93427 1.000 23.38922  ? 1229 THR   B N    1 
ATOM   3564 C  CA   . THR   B 2 177 ? -17.90602 -36.17634 -32.15234 1.000 22.97518  ? 1229 THR   B CA   1 
ATOM   3565 C  C    . THR   B 2 177 ? -18.75910 -36.82936 -33.24026 1.000 26.03950  ? 1229 THR   B C    1 
ATOM   3566 O  O    . THR   B 2 177 ? -18.81220 -38.05537 -33.33516 1.000 28.55052  ? 1229 THR   B O    1 
ATOM   3567 C  CB   . THR   B 2 177 ? -16.45802 -36.02448 -32.61140 1.000 22.69031  ? 1229 THR   B CB   1 
ATOM   3568 O  OG1  . THR   B 2 177 ? -16.40600 -35.20058 -33.78747 1.000 26.59286  ? 1229 THR   B OG1  1 
ATOM   3569 C  CG2  . THR   B 2 177 ? -15.89213 -37.39255 -32.94031 1.000 23.45705  ? 1229 THR   B CG2  1 
ATOM   3570 N  N    . PHE   B 2 178 ? -19.45907 -36.01038 -34.02330 1.000 27.84009  ? 1230 PHE   B N    1 
ATOM   3571 C  CA   . PHE   B 2 178 ? -20.19715 -36.44542 -35.21124 1.000 28.92961  ? 1230 PHE   B CA   1 
ATOM   3572 C  C    . PHE   B 2 178 ? -19.23820 -36.65658 -36.38125 1.000 27.80262  ? 1230 PHE   B C    1 
ATOM   3573 O  O    . PHE   B 2 178 ? -18.19416 -36.02166 -36.45834 1.000 23.96766  ? 1230 PHE   B O    1 
ATOM   3574 C  CB   . PHE   B 2 178 ? -21.19508 -35.37438 -35.66229 1.000 27.96747  ? 1230 PHE   B CB   1 
ATOM   3575 C  CG   . PHE   B 2 178 ? -22.48406 -35.35923 -34.91924 1.000 29.54114  ? 1230 PHE   B CG   1 
ATOM   3576 C  CD1  . PHE   B 2 178 ? -23.47713 -36.29518 -35.20413 1.000 31.93736  ? 1230 PHE   B CD1  1 
ATOM   3577 C  CD2  . PHE   B 2 178 ? -22.75295 -34.35714 -34.00131 1.000 27.44342  ? 1230 PHE   B CD2  1 
ATOM   3578 C  CE1  . PHE   B 2 178 ? -24.69511 -36.26104 -34.54809 1.000 29.54689  ? 1230 PHE   B CE1  1 
ATOM   3579 C  CE2  . PHE   B 2 178 ? -23.97092 -34.31899 -33.32627 1.000 30.72087  ? 1230 PHE   B CE2  1 
ATOM   3580 C  CZ   . PHE   B 2 178 ? -24.94800 -35.26395 -33.60716 1.000 30.56857  ? 1230 PHE   B CZ   1 
ATOM   3581 N  N    . ASN   B 2 179 ? -19.62730 -37.50463 -37.33117 1.000 28.07078  ? 1231 ASN   B N    1 
ATOM   3582 C  CA   . ASN   B 2 179 ? -18.89935 -37.60078 -38.59119 1.000 28.73543  ? 1231 ASN   B CA   1 
ATOM   3583 C  C    . ASN   B 2 179 ? -19.39731 -36.53182 -39.55126 1.000 30.02354  ? 1231 ASN   B C    1 
ATOM   3584 O  O    . ASN   B 2 179 ? -20.35324 -35.79173 -39.25928 1.000 24.40497  ? 1231 ASN   B O    1 
ATOM   3585 C  CB   . ASN   B 2 179 ? -19.03647 -39.01281 -39.17207 1.000 30.23763  ? 1231 ASN   B CB   1 
ATOM   3586 C  CG   . ASN   B 2 179 ? -20.42851 -39.29776 -39.75500 1.000 28.92375  ? 1231 ASN   B CG   1 
ATOM   3587 O  OD1  . ASN   B 2 179 ? -21.44546 -38.77165 -39.29501 1.000 30.77872  ? 1231 ASN   B OD1  1 
ATOM   3588 N  ND2  . ASN   B 2 179 ? -20.46961 -40.13984 -40.78393 1.000 30.74375  ? 1231 ASN   B ND2  1 
ATOM   3589 N  N    . PRO   B 2 180 ? -18.74734 -36.38296 -40.71029 1.000 30.39102  ? 1232 PRO   B N    1 
ATOM   3590 C  CA   . PRO   B 2 180 ? -19.07228 -35.23200 -41.57437 1.000 29.86119  ? 1232 PRO   B CA   1 
ATOM   3591 C  C    . PRO   B 2 180 ? -20.53129 -35.15693 -41.99833 1.000 33.42905  ? 1232 PRO   B C    1 
ATOM   3592 O  O    . PRO   B 2 180 ? -21.04722 -34.04891 -42.21640 1.000 33.23399  ? 1232 PRO   B O    1 
ATOM   3593 C  CB   . PRO   B 2 180 ? -18.14034 -35.42916 -42.77139 1.000 29.05231  ? 1232 PRO   B CB   1 
ATOM   3594 C  CG   . PRO   B 2 180 ? -16.94937 -36.10920 -42.15738 1.000 25.92133  ? 1232 PRO   B CG   1 
ATOM   3595 C  CD   . PRO   B 2 180 ? -17.52840 -37.07308 -41.16228 1.000 30.12508  ? 1232 PRO   B CD   1 
ATOM   3596 N  N    . THR   B 2 181 ? -21.21838 -36.29089 -42.11621 1.000 27.10914  ? 1233 THR   B N    1 
ATOM   3597 C  CA   . THR   B 2 181 ? -22.60640 -36.30182 -42.56116 1.000 33.21619  ? 1233 THR   B CA   1 
ATOM   3598 C  C    . THR   B 2 181 ? -23.58537 -36.52166 -41.41411 1.000 33.80903  ? 1233 THR   B C    1 
ATOM   3599 O  O    . THR   B 2 181 ? -24.78439 -36.70559 -41.65605 1.000 32.08032  ? 1233 THR   B O    1 
ATOM   3600 C  CB   . THR   B 2 181 ? -22.80151 -37.34890 -43.67107 1.000 36.61475  ? 1233 THR   B CB   1 
ATOM   3601 O  OG1  . THR   B 2 181 ? -22.05959 -38.54393 -43.37900 1.000 36.28048  ? 1233 THR   B OG1  1 
ATOM   3602 C  CG2  . THR   B 2 181 ? -22.31452 -36.77804 -44.99513 1.000 34.10561  ? 1233 THR   B CG2  1 
ATOM   3603 N  N    . ASP   B 2 182 ? -23.10932 -36.47060 -40.17013 1.000 33.15023  ? 1234 ASP   B N    1 
ATOM   3604 C  CA   . ASP   B 2 182 ? -23.94028 -36.46344 -38.96710 1.000 35.14427  ? 1234 ASP   B CA   1 
ATOM   3605 C  C    . ASP   B 2 182 ? -24.64737 -37.78337 -38.70597 1.000 34.17289  ? 1234 ASP   B C    1 
ATOM   3606 O  O    . ASP   B 2 182 ? -25.44334 -37.86524 -37.75394 1.000 33.94145  ? 1234 ASP   B O    1 
ATOM   3607 C  CB   . ASP   B 2 182 ? -24.99320 -35.35237 -39.00815 1.000 34.54477  ? 1234 ASP   B CB   1 
ATOM   3608 C  CG   . ASP   B 2 182 ? -24.37411 -33.98743 -39.17728 1.000 36.90223  ? 1234 ASP   B CG   1 
ATOM   3609 O  OD1  . ASP   B 2 182 ? -23.26707 -33.77247 -38.62934 1.000 38.51945  ? 1234 ASP   B OD1  1 
ATOM   3610 O  OD2  . ASP   B 2 182 ? -24.99007 -33.13644 -39.84233 1.000 39.15807  ? 1234 ASP   B OD2  1 
ATOM   3611 N  N    . ASP   B 2 183 ? -24.39447 -38.81745 -39.50590 1.000 35.91466  ? 1235 ASP   B N    1 
ATOM   3612 C  CA   . ASP   B 2 183 ? -25.08656 -40.08239 -39.33677 1.000 37.12982  ? 1235 ASP   B CA   1 
ATOM   3613 C  C    . ASP   B 2 183 ? -24.38159 -41.00736 -38.36073 1.000 32.70863  ? 1235 ASP   B C    1 
ATOM   3614 O  O    . ASP   B 2 183 ? -24.99264 -41.97228 -37.89363 1.000 33.93652  ? 1235 ASP   B O    1 
ATOM   3615 C  CB   . ASP   B 2 183 ? -25.24765 -40.77849 -40.69771 1.000 38.08234  ? 1235 ASP   B CB   1 
ATOM   3616 C  CG   . ASP   B 2 183 ? -23.91070 -40.98964 -41.41574 1.000 43.73632  ? 1235 ASP   B CG   1 
ATOM   3617 O  OD1  . ASP   B 2 183 ? -23.21964 -39.99271 -41.74285 1.000 42.27406  ? 1235 ASP   B OD1  1 
ATOM   3618 O  OD2  . ASP   B 2 183 ? -23.55379 -42.16568 -41.66366 1.000 42.28509  ? 1235 ASP   B OD2  1 
ATOM   3619 N  N    . LEU   B 2 184 ? -23.12456 -40.72443 -38.03679 1.000 26.88613  ? 1236 LEU   B N    1 
ATOM   3620 C  CA   . LEU   B 2 184 ? -22.32958 -41.54942 -37.14476 1.000 29.45924  ? 1236 LEU   B CA   1 
ATOM   3621 C  C    . LEU   B 2 184 ? -21.75348 -40.69637 -36.01684 1.000 31.54412  ? 1236 LEU   B C    1 
ATOM   3622 O  O    . LEU   B 2 184 ? -21.55140 -39.48539 -36.15995 1.000 30.76463  ? 1236 LEU   B O    1 
ATOM   3623 C  CB   . LEU   B 2 184 ? -21.18166 -42.23456 -37.89774 1.000 30.37915  ? 1236 LEU   B CB   1 
ATOM   3624 C  CG   . LEU   B 2 184 ? -21.53777 -43.14463 -39.08066 1.000 32.66721  ? 1236 LEU   B CG   1 
ATOM   3625 C  CD1  . LEU   B 2 184 ? -20.26283 -43.63277 -39.73767 1.000 29.31138  ? 1236 LEU   B CD1  1 
ATOM   3626 C  CD2  . LEU   B 2 184 ? -22.36084 -44.32353 -38.59854 1.000 30.23789  ? 1236 LEU   B CD2  1 
ATOM   3627 N  N    . VAL   B 2 185 ? -21.49249 -41.33930 -34.88980 1.000 27.86920  ? 1237 VAL   B N    1 
ATOM   3628 C  CA   . VAL   B 2 185 ? -20.82640 -40.68926 -33.77188 1.000 27.43828  ? 1237 VAL   B CA   1 
ATOM   3629 C  C    . VAL   B 2 185 ? -19.67845 -41.58031 -33.35185 1.000 26.28813  ? 1237 VAL   B C    1 
ATOM   3630 O  O    . VAL   B 2 185 ? -19.81854 -42.80729 -33.30875 1.000 28.89487  ? 1237 VAL   B O    1 
ATOM   3631 C  CB   . VAL   B 2 185 ? -21.77034 -40.42509 -32.57987 1.000 28.10459  ? 1237 VAL   B CB   1 
ATOM   3632 C  CG1  . VAL   B 2 185 ? -20.97229 -40.37605 -31.26590 1.000 23.07105  ? 1237 VAL   B CG1  1 
ATOM   3633 C  CG2  . VAL   B 2 185 ? -22.55025 -39.12105 -32.78894 1.000 27.55426  ? 1237 VAL   B CG2  1 
ATOM   3634 N  N    . LEU   B 2 186 ? -18.54640 -40.96637 -33.05094 1.000 22.23060  ? 1238 LEU   B N    1 
ATOM   3635 C  CA   . LEU   B 2 186 ? -17.46942 -41.64039 -32.34992 1.000 25.24683  ? 1238 LEU   B CA   1 
ATOM   3636 C  C    . LEU   B 2 186 ? -17.48833 -41.16127 -30.90096 1.000 26.70941  ? 1238 LEU   B C    1 
ATOM   3637 O  O    . LEU   B 2 186 ? -17.47624 -39.94825 -30.64906 1.000 27.59297  ? 1238 LEU   B O    1 
ATOM   3638 C  CB   . LEU   B 2 186 ? -16.13342 -41.33154 -33.01999 1.000 24.96547  ? 1238 LEU   B CB   1 
ATOM   3639 C  CG   . LEU   B 2 186 ? -14.98048 -42.29561 -32.82396 1.000 33.54956  ? 1238 LEU   B CG   1 
ATOM   3640 C  CD1  . LEU   B 2 186 ? -15.42760 -43.73660 -33.15983 1.000 30.36205  ? 1238 LEU   B CD1  1 
ATOM   3641 C  CD2  . LEU   B 2 186 ? -13.82248 -41.81876 -33.70704 1.000 26.91281  ? 1238 LEU   B CD2  1 
ATOM   3642 N  N    . ASN   B 2 187 ? -17.57937 -42.10019 -29.95688 1.000 24.55287  ? 1239 ASN   B N    1 
ATOM   3643 C  CA   . ASN   B 2 187 ? -17.55629 -41.77008 -28.53691 1.000 23.56303  ? 1239 ASN   B CA   1 
ATOM   3644 C  C    . ASN   B 2 187 ? -16.78334 -42.83408 -27.78285 1.000 25.42484  ? 1239 ASN   B C    1 
ATOM   3645 O  O    . ASN   B 2 187 ? -17.15643 -44.01305 -27.81375 1.000 30.48327  ? 1239 ASN   B O    1 
ATOM   3646 C  CB   . ASN   B 2 187 ? -18.96226 -41.63993 -27.93087 1.000 26.18889  ? 1239 ASN   B CB   1 
ATOM   3647 C  CG   . ASN   B 2 187 ? -18.89619 -41.38482 -26.43189 1.000 26.12691  ? 1239 ASN   B CG   1 
ATOM   3648 O  OD1  . ASN   B 2 187 ? -18.29110 -40.40783 -26.01399 1.000 25.93023  ? 1239 ASN   B OD1  1 
ATOM   3649 N  ND2  . ASN   B 2 187 ? -19.46523 -42.28571 -25.61980 1.000 23.63739  ? 1239 ASN   B ND2  1 
ATOM   3650 N  N    . ASP   B 2 188 ? -15.72829 -42.41610 -27.08492 1.000 24.26157  ? 1240 ASP   B N    1 
ATOM   3651 C  CA   . ASP   B 2 188 ? -14.92932 -43.32109 -26.27388 1.000 28.02641  ? 1240 ASP   B CA   1 
ATOM   3652 C  C    . ASP   B 2 188 ? -14.39944 -44.48919 -27.09981 1.000 27.89075  ? 1240 ASP   B C    1 
ATOM   3653 O  O    . ASP   B 2 188 ? -14.26950 -45.61516 -26.60872 1.000 30.03794  ? 1240 ASP   B O    1 
ATOM   3654 C  CB   . ASP   B 2 188 ? -15.73132 -43.83294 -25.07581 1.000 27.82005  ? 1240 ASP   B CB   1 
ATOM   3655 C  CG   . ASP   B 2 188 ? -14.84632 -44.35491 -23.96380 1.000 31.49566  ? 1240 ASP   B CG   1 
ATOM   3656 O  OD1  . ASP   B 2 188 ? -13.69428 -43.87099 -23.84788 1.000 28.33795  ? 1240 ASP   B OD1  1 
ATOM   3657 O  OD2  . ASP   B 2 188 ? -15.30835 -45.25382 -23.20171 1.000 26.26109  ? 1240 ASP   B OD2  1 
ATOM   3658 N  N    . GLY   B 2 189 ? -14.06546 -44.21632 -28.35384 1.000 28.89380  ? 1241 GLY   B N    1 
ATOM   3659 C  CA   . GLY   B 2 189 ? -13.56257 -45.24742 -29.24878 1.000 28.13331  ? 1241 GLY   B CA   1 
ATOM   3660 C  C    . GLY   B 2 189 ? -14.60666 -46.21639 -29.76266 1.000 30.28061  ? 1241 GLY   B C    1 
ATOM   3661 O  O    . GLY   B 2 189 ? -14.23975 -47.25446 -30.32159 1.000 32.25114  ? 1241 GLY   B O    1 
ATOM   3662 N  N    . VAL   B 2 190 ? -15.89263 -45.92628 -29.57064 1.000 26.78049  ? 1242 VAL   B N    1 
ATOM   3663 C  CA   . VAL   B 2 190 ? -16.98571 -46.74824 -30.07454 1.000 29.17989  ? 1242 VAL   B CA   1 
ATOM   3664 C  C    . VAL   B 2 190 ? -17.68269 -45.97528 -31.18557 1.000 31.43448  ? 1242 VAL   B C    1 
ATOM   3665 O  O    . VAL   B 2 190 ? -18.05360 -44.80624 -31.00465 1.000 26.37821  ? 1242 VAL   B O    1 
ATOM   3666 C  CB   . VAL   B 2 190 ? -17.97769 -47.12008 -28.95947 1.000 31.20484  ? 1242 VAL   B CB   1 
ATOM   3667 C  CG1  . VAL   B 2 190 ? -19.09178 -48.00705 -29.51136 1.000 33.14249  ? 1242 VAL   B CG1  1 
ATOM   3668 C  CG2  . VAL   B 2 190 ? -17.25770 -47.79104 -27.81444 1.000 27.91217  ? 1242 VAL   B CG2  1 
ATOM   3669 N  N    . LEU   B 2 191 ? -17.84778 -46.61636 -32.33952 1.000 26.59957  ? 1243 LEU   B N    1 
ATOM   3670 C  CA   . LEU   B 2 191 ? -18.56478 -46.01740 -33.45354 1.000 27.38246  ? 1243 LEU   B CA   1 
ATOM   3671 C  C    . LEU   B 2 191 ? -20.05979 -46.30328 -33.31546 1.000 31.62636  ? 1243 LEU   B C    1 
ATOM   3672 O  O    . LEU   B 2 191 ? -20.46387 -47.46324 -33.15935 1.000 32.77650  ? 1243 LEU   B O    1 
ATOM   3673 C  CB   . LEU   B 2 191 ? -18.02786 -46.56654 -34.77751 1.000 30.48135  ? 1243 LEU   B CB   1 
ATOM   3674 C  CG   . LEU   B 2 191 ? -18.62286 -45.97360 -36.05354 1.000 30.08450  ? 1243 LEU   B CG   1 
ATOM   3675 C  CD1  . LEU   B 2 191 ? -18.26176 -44.49663 -36.18367 1.000 31.01419  ? 1243 LEU   B CD1  1 
ATOM   3676 C  CD2  . LEU   B 2 191 ? -18.15097 -46.76173 -37.28749 1.000 32.26256  ? 1243 LEU   B CD2  1 
ATOM   3677 N  N    . TRP   B 2 192 ? -20.87872 -45.25822 -33.38651 1.000 28.37803  ? 1244 TRP   B N    1 
ATOM   3678 C  CA   . TRP   B 2 192 ? -22.31572 -45.38910 -33.17945 1.000 28.03462  ? 1244 TRP   B CA   1 
ATOM   3679 C  C    . TRP   B 2 192 ? -23.08674 -44.98815 -34.42946 1.000 32.81119  ? 1244 TRP   B C    1 
ATOM   3680 O  O    . TRP   B 2 192 ? -22.74369 -44.01122 -35.10855 1.000 31.11435  ? 1244 TRP   B O    1 
ATOM   3681 C  CB   . TRP   B 2 192 ? -22.80262 -44.52297 -32.00850 1.000 28.86546  ? 1244 TRP   B CB   1 
ATOM   3682 C  CG   . TRP   B 2 192 ? -22.32760 -44.95390 -30.66849 1.000 30.10417  ? 1244 TRP   B CG   1 
ATOM   3683 C  CD1  . TRP   B 2 192 ? -21.12056 -44.66194 -30.08655 1.000 29.80749  ? 1244 TRP   B CD1  1 
ATOM   3684 C  CD2  . TRP   B 2 192 ? -23.05662 -45.73177 -29.71540 1.000 32.76813  ? 1244 TRP   B CD2  1 
ATOM   3685 N  NE1  . TRP   B 2 192 ? -21.05355 -45.22885 -28.82951 1.000 28.48479  ? 1244 TRP   B NE1  1 
ATOM   3686 C  CE2  . TRP   B 2 192 ? -22.23359 -45.87974 -28.57542 1.000 34.64102  ? 1244 TRP   B CE2  1 
ATOM   3687 C  CE3  . TRP   B 2 192 ? -24.32666 -46.31968 -29.71031 1.000 33.60514  ? 1244 TRP   B CE3  1 
ATOM   3688 C  CZ2  . TRP   B 2 192 ? -22.64260 -46.60563 -27.44134 1.000 34.67506  ? 1244 TRP   B CZ2  1 
ATOM   3689 C  CZ3  . TRP   B 2 192 ? -24.73367 -47.02656 -28.58424 1.000 34.34203  ? 1244 TRP   B CZ3  1 
ATOM   3690 C  CH2  . TRP   B 2 192 ? -23.88565 -47.17154 -27.47126 1.000 34.37025  ? 1244 TRP   B CH2  1 
ATOM   3691 N  N    . ASP   B 2 193 ? -24.15780 -45.72309 -34.70436 1.000 32.80246  ? 1245 ASP   B N    1 
ATOM   3692 C  CA   . ASP   B 2 193 ? -25.11281 -45.32110 -35.72536 1.000 33.48646  ? 1245 ASP   B CA   1 
ATOM   3693 C  C    . ASP   B 2 193 ? -26.17672 -44.46597 -35.05139 1.000 31.46084  ? 1245 ASP   B C    1 
ATOM   3694 O  O    . ASP   B 2 193 ? -26.94173 -44.95985 -34.21532 1.000 32.88195  ? 1245 ASP   B O    1 
ATOM   3695 C  CB   . ASP   B 2 193 ? -25.73192 -46.53411 -36.41424 1.000 33.08359  ? 1245 ASP   B CB   1 
ATOM   3696 C  CG   . ASP   B 2 193 ? -26.80992 -46.13911 -37.39823 1.000 36.18810  ? 1245 ASP   B CG   1 
ATOM   3697 O  OD1  . ASP   B 2 193 ? -26.45193 -45.69922 -38.50528 1.000 43.36015  ? 1245 ASP   B OD1  1 
ATOM   3698 O  OD2  . ASP   B 2 193 ? -28.00792 -46.22700 -37.05318 1.000 39.47678  ? 1245 ASP   B OD2  1 
ATOM   3699 N  N    . VAL   B 2 194 ? -26.23664 -43.18500 -35.41849 1.000 33.15653  ? 1246 VAL   B N    1 
ATOM   3700 C  CA   . VAL   B 2 194 ? -27.10355 -42.25188 -34.70153 1.000 34.00751  ? 1246 VAL   B CA   1 
ATOM   3701 C  C    . VAL   B 2 194 ? -28.57158 -42.63578 -34.87245 1.000 39.24201  ? 1246 VAL   B C    1 
ATOM   3702 O  O    . VAL   B 2 194 ? -29.32355 -42.74065 -33.89341 1.000 38.83576  ? 1246 VAL   B O    1 
ATOM   3703 C  CB   . VAL   B 2 194 ? -26.83846 -40.80693 -35.16365 1.000 35.58430  ? 1246 VAL   B CB   1 
ATOM   3704 C  CG1  . VAL   B 2 194 ? -27.82737 -39.84981 -34.50069 1.000 33.77312  ? 1246 VAL   B CG1  1 
ATOM   3705 C  CG2  . VAL   B 2 194 ? -25.37542 -40.38501 -34.86474 1.000 27.64697  ? 1246 VAL   B CG2  1 
ATOM   3706 N  N    . ARG   B 2 195 ? -29.00264 -42.83585 -36.12242 1.000 36.91647  ? 1247 ARG   B N    1 
ATOM   3707 C  CA   . ARG   B 2 195 ? -30.41567 -43.07877 -36.42635 1.000 39.03808  ? 1247 ARG   B CA   1 
ATOM   3708 C  C    . ARG   B 2 195 ? -30.98272 -44.18966 -35.55624 1.000 35.79339  ? 1247 ARG   B C    1 
ATOM   3709 O  O    . ARG   B 2 195 ? -32.06769 -44.05554 -34.98021 1.000 42.88806  ? 1247 ARG   B O    1 
ATOM   3710 C  CB   . ARG   B 2 195 ? -30.55575 -43.42488 -37.91031 1.000 40.60603  ? 1247 ARG   B CB   1 
ATOM   3711 C  CG   . ARG   B 2 195 ? -31.94776 -43.29383 -38.52327 1.000 53.20276  ? 1247 ARG   B CG   1 
ATOM   3712 C  CD   . ARG   B 2 195 ? -31.78378 -42.85596 -39.98532 1.000 52.96679  ? 1247 ARG   B CD   1 
ATOM   3713 N  NE   . ARG   B 2 195 ? -32.94883 -43.09994 -40.83425 1.000 66.98014  ? 1247 ARG   B NE   1 
ATOM   3714 C  CZ   . ARG   B 2 195 ? -32.92387 -43.08305 -42.16626 1.000 68.24974  ? 1247 ARG   B CZ   1 
ATOM   3715 N  NH1  . ARG   B 2 195 ? -31.79988 -42.86818 -42.83831 1.000 62.69656  ? 1247 ARG   B NH1  1 
ATOM   3716 N  NH2  . ARG   B 2 195 ? -34.05491 -43.28302 -42.84320 1.000 65.67391  ? 1247 ARG   B NH2  1 
ATOM   3717 N  N    . SER   B 2 196 ? -30.25779 -45.29971 -35.45018 1.000 38.04241  ? 1248 SER   B N    1 
ATOM   3718 C  CA   . SER   B 2 196 ? -30.67085 -46.47062 -34.69307 1.000 38.74578  ? 1248 SER   B CA   1 
ATOM   3719 C  C    . SER   B 2 196 ? -30.18580 -46.43754 -33.25709 1.000 43.11994  ? 1248 SER   B C    1 
ATOM   3720 O  O    . SER   B 2 196 ? -30.52184 -47.34645 -32.48701 1.000 40.74173  ? 1248 SER   B O    1 
ATOM   3721 C  CB   . SER   B 2 196 ? -30.14097 -47.74171 -35.36299 1.000 39.88788  ? 1248 SER   B CB   1 
ATOM   3722 O  OG   . SER   B 2 196 ? -28.74097 -47.87279 -35.14603 1.000 44.53927  ? 1248 SER   B OG   1 
ATOM   3723 N  N    . ALA   B 2 197 ? -29.38371 -45.43157 -32.88920 1.000 41.16432  ? 1249 ALA   B N    1 
ATOM   3724 C  CA   . ALA   B 2 197 ? -28.80266 -45.34350 -31.55322 1.000 38.04237  ? 1249 ALA   B CA   1 
ATOM   3725 C  C    . ALA   B 2 197 ? -28.13074 -46.65452 -31.16115 1.000 39.25236  ? 1249 ALA   B C    1 
ATOM   3726 O  O    . ALA   B 2 197 ? -28.24473 -47.12242 -30.02710 1.000 39.48758  ? 1249 ALA   B O    1 
ATOM   3727 C  CB   . ALA   B 2 197 ? -29.86459 -44.94035 -30.52422 1.000 39.24166  ? 1249 ALA   B CB   1 
ATOM   3728 N  N    . GLN   B 2 198 ? -27.41582 -47.25465 -32.10012 1.000 35.64023  ? 1250 GLN   B N    1 
ATOM   3729 C  CA   . GLN   B 2 198 ? -26.75390 -48.53168 -31.86705 1.000 40.43393  ? 1250 GLN   B CA   1 
ATOM   3730 C  C    . GLN   B 2 198 ? -25.25190 -48.44481 -32.11511 1.000 35.07013  ? 1250 GLN   B C    1 
ATOM   3731 O  O    . GLN   B 2 198 ? -24.79389 -47.75791 -33.04018 1.000 35.93285  ? 1250 GLN   B O    1 
ATOM   3732 C  CB   . GLN   B 2 198 ? -27.34701 -49.62271 -32.75894 1.000 42.77697  ? 1250 GLN   B CB   1 
ATOM   3733 C  CG   . GLN   B 2 198 ? -27.60208 -50.89963 -32.00783 1.000 53.65173  ? 1250 GLN   B CG   1 
ATOM   3734 C  CD   . GLN   B 2 198 ? -28.89905 -50.84847 -31.22579 1.000 62.60770  ? 1250 GLN   B CD   1 
ATOM   3735 O  OE1  . GLN   B 2 198 ? -29.98306 -50.82744 -31.81575 1.000 66.93447  ? 1250 GLN   B OE1  1 
ATOM   3736 N  NE2  . GLN   B 2 198 ? -28.79900 -50.82037 -29.89379 1.000 58.59174  ? 1250 GLN   B NE2  1 
ATOM   3737 N  N    . ALA   B 2 199 ? -24.49092 -49.14379 -31.27508 1.000 33.05744  ? 1251 ALA   B N    1 
ATOM   3738 C  CA   . ALA   B 2 199 ? -23.05194 -49.25591 -31.45612 1.000 33.75761  ? 1251 ALA   B CA   1 
ATOM   3739 C  C    . ALA   B 2 199 ? -22.76905 -50.22802 -32.59405 1.000 40.61513  ? 1251 ALA   B C    1 
ATOM   3740 O  O    . ALA   B 2 199 ? -23.23013 -51.37299 -32.56195 1.000 41.43702  ? 1251 ALA   B O    1 
ATOM   3741 C  CB   . ALA   B 2 199 ? -22.38893 -49.73286 -30.17211 1.000 32.06919  ? 1251 ALA   B CB   1 
ATOM   3742 N  N    . ILE   B 2 200 ? -22.02505 -49.78216 -33.60212 1.000 36.87760  ? 1252 ILE   B N    1 
ATOM   3743 C  CA   . ILE   B 2 200 ? -21.67516 -50.66027 -34.71106 1.000 37.31514  ? 1252 ILE   B CA   1 
ATOM   3744 C  C    . ILE   B 2 200 ? -20.23619 -51.17737 -34.65707 1.000 34.69569  ? 1252 ILE   B C    1 
ATOM   3745 O  O    . ILE   B 2 200 ? -19.92429 -52.17145 -35.32800 1.000 38.71169  ? 1252 ILE   B O    1 
ATOM   3746 C  CB   . ILE   B 2 200 ? -21.95015 -49.97436 -36.06310 1.000 38.26154  ? 1252 ILE   B CB   1 
ATOM   3747 C  CG1  . ILE   B 2 200 ? -21.07707 -48.74744 -36.26123 1.000 38.32398  ? 1252 ILE   B CG1  1 
ATOM   3748 C  CG2  . ILE   B 2 200 ? -23.39913 -49.57226 -36.15808 1.000 43.18559  ? 1252 ILE   B CG2  1 
ATOM   3749 C  CD1  . ILE   B 2 200 ? -21.53305 -47.87950 -37.44028 1.000 35.92259  ? 1252 ILE   B CD1  1 
ATOM   3750 N  N    . HIS   B 2 201 ? -19.36112 -50.56637 -33.86815 1.000 31.12563  ? 1253 HIS   B N    1 
ATOM   3751 C  CA   . HIS   B 2 201 ? -18.00016 -51.08647 -33.82716 1.000 33.80129  ? 1253 HIS   B CA   1 
ATOM   3752 C  C    . HIS   B 2 201 ? -17.25107 -50.46243 -32.65923 1.000 37.48731  ? 1253 HIS   B C    1 
ATOM   3753 O  O    . HIS   B 2 201 ? -17.33897 -49.25340 -32.43832 1.000 34.96114  ? 1253 HIS   B O    1 
ATOM   3754 C  CB   . HIS   B 2 201 ? -17.25318 -50.80362 -35.14421 1.000 33.90932  ? 1253 HIS   B CB   1 
ATOM   3755 C  CG   . HIS   B 2 201 ? -15.96024 -51.54773 -35.28019 1.000 37.61533  ? 1253 HIS   B CG   1 
ATOM   3756 N  ND1  . HIS   B 2 201 ? -14.73119 -50.95080 -35.09228 1.000 38.21546  ? 1253 HIS   B ND1  1 
ATOM   3757 C  CD2  . HIS   B 2 201 ? -15.70534 -52.84577 -35.57010 1.000 35.74161  ? 1253 HIS   B CD2  1 
ATOM   3758 C  CE1  . HIS   B 2 201 ? -13.77626 -51.84689 -35.27225 1.000 34.51509  ? 1253 HIS   B CE1  1 
ATOM   3759 N  NE2  . HIS   B 2 201 ? -14.34136 -53.00487 -35.56113 1.000 40.04003  ? 1253 HIS   B NE2  1 
ATOM   3760 N  N    . LYS   B 2 202 ? -16.51710 -51.28642 -31.92519 1.000 34.41519  ? 1254 LYS   B N    1 
ATOM   3761 C  CA   . LYS   B 2 202 ? -15.61403 -50.80341 -30.89326 1.000 35.82472  ? 1254 LYS   B CA   1 
ATOM   3762 C  C    . LYS   B 2 202 ? -14.19306 -50.94755 -31.40530 1.000 34.45617  ? 1254 LYS   B C    1 
ATOM   3763 O  O    . LYS   B 2 202 ? -13.78115 -52.04761 -31.78923 1.000 37.27836  ? 1254 LYS   B O    1 
ATOM   3764 C  CB   . LYS   B 2 202 ? -15.76204 -51.57329 -29.58020 1.000 37.80710  ? 1254 LYS   B CB   1 
ATOM   3765 C  CG   . LYS   B 2 202 ? -14.59498 -51.26530 -28.64926 1.000 32.98409  ? 1254 LYS   B CG   1 
ATOM   3766 C  CD   . LYS   B 2 202 ? -14.65999 -51.97519 -27.33320 1.000 40.16054  ? 1254 LYS   B CD   1 
ATOM   3767 C  CE   . LYS   B 2 202 ? -13.29596 -51.92324 -26.69526 1.000 38.06551  ? 1254 LYS   B CE   1 
ATOM   3768 N  NZ   . LYS   B 2 202 ? -13.32296 -52.58714 -25.39020 1.000 48.23510  ? 1254 LYS   B NZ   1 
ATOM   3769 N  N    . PHE   B 2 203 ? -13.46098 -49.84460 -31.43142 1.000 30.32305  ? 1255 PHE   B N    1 
ATOM   3770 C  CA   . PHE   B 2 203 ? -12.04099 -49.87173 -31.73546 1.000 30.83733  ? 1255 PHE   B CA   1 
ATOM   3771 C  C    . PHE   B 2 203 ? -11.26697 -50.16069 -30.45647 1.000 31.74219  ? 1255 PHE   B C    1 
ATOM   3772 O  O    . PHE   B 2 203 ? -11.58589 -49.62658 -29.38950 1.000 33.25715  ? 1255 PHE   B O    1 
ATOM   3773 C  CB   . PHE   B 2 203 ? -11.59292 -48.54781 -32.35759 1.000 25.47438  ? 1255 PHE   B CB   1 
ATOM   3774 C  CG   . PHE   B 2 203 ? -12.23495 -48.26187 -33.67259 1.000 29.13128  ? 1255 PHE   B CG   1 
ATOM   3775 C  CD1  . PHE   B 2 203 ? -11.66802 -48.72000 -34.84757 1.000 31.77924  ? 1255 PHE   B CD1  1 
ATOM   3776 C  CD2  . PHE   B 2 203 ? -13.42890 -47.54579 -33.73860 1.000 30.84342  ? 1255 PHE   B CD2  1 
ATOM   3777 C  CE1  . PHE   B 2 203 ? -12.28105 -48.46906 -36.07357 1.000 30.15192  ? 1255 PHE   B CE1  1 
ATOM   3778 C  CE2  . PHE   B 2 203 ? -14.03392 -47.28184 -34.94060 1.000 29.44712  ? 1255 PHE   B CE2  1 
ATOM   3779 C  CZ   . PHE   B 2 203 ? -13.46800 -47.74498 -36.11658 1.000 33.67821  ? 1255 PHE   B CZ   1 
ATOM   3780 N  N    . ASP   B 2 204 ? -10.25703 -51.02177 -30.56944 1.000 31.54058  ? 1256 ASP   B N    1 
ATOM   3781 C  CA   . ASP   B 2 204 ? -9.48502  -51.41173 -29.40643 1.000 28.89943  ? 1256 ASP   B CA   1 
ATOM   3782 C  C    . ASP   B 2 204 ? -8.74191  -50.21974 -28.81755 1.000 33.70691  ? 1256 ASP   B C    1 
ATOM   3783 O  O    . ASP   B 2 204 ? -8.38287  -49.26382 -29.51164 1.000 28.81899  ? 1256 ASP   B O    1 
ATOM   3784 C  CB   . ASP   B 2 204 ? -8.47611  -52.49683 -29.76638 1.000 37.22785  ? 1256 ASP   B CB   1 
ATOM   3785 C  CG   . ASP   B 2 204 ? -9.13622  -53.82681 -30.08026 1.000 41.10879  ? 1256 ASP   B CG   1 
ATOM   3786 O  OD1  . ASP   B 2 204 ? -10.23622 -54.09169 -29.55720 1.000 43.15220  ? 1256 ASP   B OD1  1 
ATOM   3787 O  OD2  . ASP   B 2 204 ? -8.54130  -54.59892 -30.85622 1.000 45.80007  ? 1256 ASP   B OD2  1 
ATOM   3788 N  N    . LYS   B 2 205 ? -8.46587  -50.31066 -27.52656 1.000 31.93651  ? 1257 LYS   B N    1 
ATOM   3789 C  CA   . LYS   B 2 205 ? -7.84277  -49.22764 -26.78567 1.000 34.26264  ? 1257 LYS   B CA   1 
ATOM   3790 C  C    . LYS   B 2 205 ? -6.33178  -49.39176 -26.82671 1.000 32.58681  ? 1257 LYS   B C    1 
ATOM   3791 O  O    . LYS   B 2 205 ? -5.80384  -50.39276 -26.33865 1.000 32.09013  ? 1257 LYS   B O    1 
ATOM   3792 C  CB   . LYS   B 2 205 ? -8.35072  -49.22349 -25.34765 1.000 31.22105  ? 1257 LYS   B CB   1 
ATOM   3793 C  CG   . LYS   B 2 205 ? -7.75061  -48.12847 -24.46376 1.000 30.78894  ? 1257 LYS   B CG   1 
ATOM   3794 C  CD   . LYS   B 2 205 ? -8.24957  -48.31132 -23.03272 1.000 27.57761  ? 1257 LYS   B CD   1 
ATOM   3795 C  CE   . LYS   B 2 205 ? -8.00645  -47.07727 -22.18083 1.000 33.09915  ? 1257 LYS   B CE   1 
ATOM   3796 N  NZ   . LYS   B 2 205 ? -8.63941  -47.21411 -20.83180 1.000 27.19712  ? 1257 LYS   B NZ   1 
ATOM   3797 N  N    . PHE   B 2 206 ? -5.63573  -48.40885 -27.39981 1.000 30.84661  ? 1258 PHE   B N    1 
ATOM   3798 C  CA   . PHE   B 2 206 ? -4.17974  -48.43996 -27.49886 1.000 29.13615  ? 1258 PHE   B CA   1 
ATOM   3799 C  C    . PHE   B 2 206 ? -3.51963  -47.23096 -26.84498 1.000 28.60461  ? 1258 PHE   B C    1 
ATOM   3800 O  O    . PHE   B 2 206 ? -2.32062  -47.01906 -27.03604 1.000 29.04846  ? 1258 PHE   B O    1 
ATOM   3801 C  CB   . PHE   B 2 206 ? -3.73980  -48.53811 -28.96687 1.000 28.95252  ? 1258 PHE   B CB   1 
ATOM   3802 C  CG   . PHE   B 2 206 ? -4.14991  -49.81914 -29.64875 1.000 32.73323  ? 1258 PHE   B CG   1 
ATOM   3803 C  CD1  . PHE   B 2 206 ? -3.58899  -51.03115 -29.27567 1.000 31.86448  ? 1258 PHE   B CD1  1 
ATOM   3804 C  CD2  . PHE   B 2 206 ? -5.06895  -49.80515 -30.68472 1.000 30.78342  ? 1258 PHE   B CD2  1 
ATOM   3805 C  CE1  . PHE   B 2 206 ? -3.96010  -52.21317 -29.88257 1.000 31.49163  ? 1258 PHE   B CE1  1 
ATOM   3806 C  CE2  . PHE   B 2 206 ? -5.44306  -50.99418 -31.31861 1.000 34.49321  ? 1258 PHE   B CE2  1 
ATOM   3807 C  CZ   . PHE   B 2 206 ? -4.88813  -52.20018 -30.91554 1.000 28.58706  ? 1258 PHE   B CZ   1 
ATOM   3808 N  N    . ASN   B 2 207 ? -4.27654  -46.40685 -26.11602 1.000 25.98394  ? 1259 ASN   B N    1 
ATOM   3809 C  CA   . ASN   B 2 207 ? -3.70343  -45.31583 -25.33812 1.000 24.12960  ? 1259 ASN   B CA   1 
ATOM   3810 C  C    . ASN   B 2 207 ? -4.70837  -44.97467 -24.25211 1.000 28.04752  ? 1259 ASN   B C    1 
ATOM   3811 O  O    . ASN   B 2 207 ? -5.84741  -45.44359 -24.27704 1.000 28.74053  ? 1259 ASN   B O    1 
ATOM   3812 C  CB   . ASN   B 2 207 ? -3.37538  -44.09792 -26.21523 1.000 24.21017  ? 1259 ASN   B CB   1 
ATOM   3813 C  CG   . ASN   B 2 207 ? -4.55432  -43.17085 -26.37526 1.000 27.67418  ? 1259 ASN   B CG   1 
ATOM   3814 O  OD1  . ASN   B 2 207 ? -5.55936  -43.49983 -27.05020 1.000 31.09614  ? 1259 ASN   B OD1  1 
ATOM   3815 N  ND2  . ASN   B 2 207 ? -4.44821  -41.99681 -25.77136 1.000 20.56312  ? 1259 ASN   B ND2  1 
ATOM   3816 N  N    . MET   B 2 208 ? -4.27628  -44.15762 -23.28719 1.000 26.28693  ? 1260 MET   B N    1 
ATOM   3817 C  CA   . MET   B 2 208 ? -5.10822  -43.88947 -22.11519 1.000 31.14870  ? 1260 MET   B CA   1 
ATOM   3818 C  C    . MET   B 2 208 ? -6.05614  -42.70542 -22.28125 1.000 27.85719  ? 1260 MET   B C    1 
ATOM   3819 O  O    . MET   B 2 208 ? -7.04210  -42.62029 -21.54022 1.000 26.87224  ? 1260 MET   B O    1 
ATOM   3820 C  CB   . MET   B 2 208 ? -4.23215  -43.64044 -20.87424 1.000 28.70172  ? 1260 MET   B CB   1 
ATOM   3821 C  CG   . MET   B 2 208 ? -3.43923  -44.85446 -20.40217 1.000 33.75475  ? 1260 MET   B CG   1 
ATOM   3822 S  SD   . MET   B 2 208 ? -4.47833  -46.34736 -20.17601 1.000 50.29412  ? 1260 MET   B SD   1 
ATOM   3823 C  CE   . MET   B 2 208 ? -5.25025  -46.02318 -18.60201 1.000 39.39054  ? 1260 MET   B CE   1 
ATOM   3824 N  N    . ASN   B 2 209 ? -5.80911  -41.82051 -23.24732 1.000 26.54273  ? 1261 ASN   B N    1 
ATOM   3825 C  CA   . ASN   B 2 209 ? -6.37801  -40.47147 -23.23941 1.000 26.60265  ? 1261 ASN   B CA   1 
ATOM   3826 C  C    . ASN   B 2 209 ? -7.24503  -40.13150 -24.44341 1.000 28.20185  ? 1261 ASN   B C    1 
ATOM   3827 O  O    . ASN   B 2 209 ? -8.35498  -39.61341 -24.26341 1.000 25.02304  ? 1261 ASN   B O    1 
ATOM   3828 C  CB   . ASN   B 2 209 ? -5.24093  -39.45654 -23.12753 1.000 25.25620  ? 1261 ASN   B CB   1 
ATOM   3829 C  CG   . ASN   B 2 209 ? -4.52489  -39.58149 -21.81255 1.000 31.60761  ? 1261 ASN   B CG   1 
ATOM   3830 O  OD1  . ASN   B 2 209 ? -5.17686  -39.66736 -20.78152 1.000 32.35138  ? 1261 ASN   B OD1  1 
ATOM   3831 N  ND2  . ASN   B 2 209 ? -3.18590  -39.65359 -21.83959 1.000 28.97626  ? 1261 ASN   B ND2  1 
ATOM   3832 N  N    . ILE   B 2 210 ? -6.76609  -40.39163 -25.65740 1.000 27.83276  ? 1262 ILE   B N    1 
ATOM   3833 C  CA   . ILE   B 2 210 ? -7.35710  -39.87369 -26.89042 1.000 23.27489  ? 1262 ILE   B CA   1 
ATOM   3834 C  C    . ILE   B 2 210 ? -8.38319  -40.85866 -27.44231 1.000 30.21530  ? 1262 ILE   B C    1 
ATOM   3835 O  O    . ILE   B 2 210 ? -8.07528  -42.03870 -27.66023 1.000 27.68286  ? 1262 ILE   B O    1 
ATOM   3836 C  CB   . ILE   B 2 210 ? -6.26211  -39.61085 -27.93048 1.000 29.21608  ? 1262 ILE   B CB   1 
ATOM   3837 C  CG1  . ILE   B 2 210 ? -5.24302  -38.60788 -27.38160 1.000 29.40353  ? 1262 ILE   B CG1  1 
ATOM   3838 C  CG2  . ILE   B 2 210 ? -6.88913  -39.18091 -29.26449 1.000 24.28024  ? 1262 ILE   B CG2  1 
ATOM   3839 C  CD1  . ILE   B 2 210 ? -5.80792  -37.21882 -27.20469 1.000 29.55147  ? 1262 ILE   B CD1  1 
ATOM   3840 N  N    . SER   B 2 211 ? -9.58816  -40.36559 -27.71630 1.000 24.99605  ? 1263 SER   B N    1 
ATOM   3841 C  CA   . SER   B 2 211 ? -10.66524 -41.21955 -28.18420 1.000 27.54007  ? 1263 SER   B CA   1 
ATOM   3842 C  C    . SER   B 2 211 ? -10.86129 -41.19766 -29.70119 1.000 28.99710  ? 1263 SER   B C    1 
ATOM   3843 O  O    . SER   B 2 211 ? -11.50638 -42.10965 -30.23310 1.000 30.79520  ? 1263 SER   B O    1 
ATOM   3844 C  CB   . SER   B 2 211 ? -11.97419 -40.82540 -27.48718 1.000 27.90457  ? 1263 SER   B CB   1 
ATOM   3845 O  OG   . SER   B 2 211 ? -12.32610 -39.47940 -27.76528 1.000 28.64028  ? 1263 SER   B OG   1 
ATOM   3846 N  N    . GLY   B 2 212 ? -10.35624 -40.18875 -30.40029 1.000 27.38772  ? 1264 GLY   B N    1 
ATOM   3847 C  CA   . GLY   B 2 212 ? -10.29630 -40.18087 -31.85129 1.000 28.37682  ? 1264 GLY   B CA   1 
ATOM   3848 C  C    . GLY   B 2 212 ? -11.33225 -39.26384 -32.49633 1.000 27.52316  ? 1264 GLY   B C    1 
ATOM   3849 O  O    . GLY   B 2 212 ? -12.29320 -38.81172 -31.87533 1.000 27.35135  ? 1264 GLY   B O    1 
ATOM   3850 N  N    . VAL   B 2 213 ? -11.12428 -39.01596 -33.79436 1.000 24.37632  ? 1265 VAL   B N    1 
ATOM   3851 C  CA   . VAL   B 2 213 ? -11.97625 -38.13596 -34.59240 1.000 25.79103  ? 1265 VAL   B CA   1 
ATOM   3852 C  C    . VAL   B 2 213 ? -12.22234 -38.74405 -35.97234 1.000 29.98295  ? 1265 VAL   B C    1 
ATOM   3853 O  O    . VAL   B 2 213 ? -11.52642 -39.66414 -36.41329 1.000 26.17096  ? 1265 VAL   B O    1 
ATOM   3854 C  CB   . VAL   B 2 213 ? -11.35715 -36.73602 -34.75953 1.000 26.88890  ? 1265 VAL   B CB   1 
ATOM   3855 C  CG1  . VAL   B 2 213 ? -11.02906 -36.13394 -33.39759 1.000 29.42791  ? 1265 VAL   B CG1  1 
ATOM   3856 C  CG2  . VAL   B 2 213 ? -10.09819 -36.83118 -35.59757 1.000 27.88096  ? 1265 VAL   B CG2  1 
ATOM   3857 N  N    . PHE   B 2 214 ? -13.19432 -38.17604 -36.67735 1.000 24.49960  ? 1266 PHE   B N    1 
ATOM   3858 C  CA   . PHE   B 2 214 ? -13.44740 -38.53313 -38.05831 1.000 26.85884  ? 1266 PHE   B CA   1 
ATOM   3859 C  C    . PHE   B 2 214 ? -12.57437 -37.70327 -38.99341 1.000 30.86697  ? 1266 PHE   B C    1 
ATOM   3860 O  O    . PHE   B 2 214 ? -12.39128 -36.50026 -38.79451 1.000 26.67920  ? 1266 PHE   B O    1 
ATOM   3861 C  CB   . PHE   B 2 214 ? -14.92239 -38.31905 -38.39628 1.000 23.28824  ? 1266 PHE   B CB   1 
ATOM   3862 C  CG   . PHE   B 2 214 ? -15.84044 -39.29393 -37.73717 1.000 27.04380  ? 1266 PHE   B CG   1 
ATOM   3863 C  CD1  . PHE   B 2 214 ? -16.02455 -40.57396 -38.27306 1.000 26.96677  ? 1266 PHE   B CD1  1 
ATOM   3864 C  CD2  . PHE   B 2 214 ? -16.54138 -38.94179 -36.59917 1.000 24.36452  ? 1266 PHE   B CD2  1 
ATOM   3865 C  CE1  . PHE   B 2 214 ? -16.89160 -41.47485 -37.66596 1.000 28.99785  ? 1266 PHE   B CE1  1 
ATOM   3866 C  CE2  . PHE   B 2 214 ? -17.40842 -39.84168 -35.98707 1.000 25.57560  ? 1266 PHE   B CE2  1 
ATOM   3867 C  CZ   . PHE   B 2 214 ? -17.58353 -41.10571 -36.51296 1.000 26.81936  ? 1266 PHE   B CZ   1 
ATOM   3868 N  N    . HIS   B 2 215 ? -12.02345 -38.35239 -40.00338 1.000 29.38452  ? 1267 HIS   B N    1 
ATOM   3869 C  CA   . HIS   B 2 215 ? -11.38544 -37.62252 -41.08746 1.000 27.11232  ? 1267 HIS   B CA   1 
ATOM   3870 C  C    . HIS   B 2 215 ? -12.46042 -36.89751 -41.90048 1.000 26.15895  ? 1267 HIS   B C    1 
ATOM   3871 O  O    . HIS   B 2 215 ? -13.58046 -37.40043 -42.03040 1.000 31.09992  ? 1267 HIS   B O    1 
ATOM   3872 C  CB   . HIS   B 2 215 ? -10.59054 -38.58365 -41.98341 1.000 26.18969  ? 1267 HIS   B CB   1 
ATOM   3873 C  CG   . HIS   B 2 215 ? -9.72153  -37.90179 -42.99449 1.000 29.58181  ? 1267 HIS   B CG   1 
ATOM   3874 N  ND1  . HIS   B 2 215 ? -10.23751 -37.18684 -44.05653 1.000 29.49323  ? 1267 HIS   B ND1  1 
ATOM   3875 C  CD2  . HIS   B 2 215 ? -8.37253  -37.83590 -43.11555 1.000 26.93084  ? 1267 HIS   B CD2  1 
ATOM   3876 C  CE1  . HIS   B 2 215 ? -9.24351  -36.70197 -44.78161 1.000 33.55332  ? 1267 HIS   B CE1  1 
ATOM   3877 N  NE2  . HIS   B 2 215 ? -8.10251  -37.08801 -44.23962 1.000 31.10492  ? 1267 HIS   B NE2  1 
ATOM   3878 N  N    . PRO   B 2 216 ? -12.17435 -35.69957 -42.41558 1.000 29.27281  ? 1268 PRO   B N    1 
ATOM   3879 C  CA   . PRO   B 2 216 ? -13.18333 -34.98956 -43.22660 1.000 29.65091  ? 1268 PRO   B CA   1 
ATOM   3880 C  C    . PRO   B 2 216 ? -13.68143 -35.78062 -44.43652 1.000 29.01685  ? 1268 PRO   B C    1 
ATOM   3881 O  O    . PRO   B 2 216 ? -14.79242 -35.52058 -44.91750 1.000 27.79476  ? 1268 PRO   B O    1 
ATOM   3882 C  CB   . PRO   B 2 216 ? -12.44425 -33.71465 -43.66873 1.000 28.29823  ? 1268 PRO   B CB   1 
ATOM   3883 C  CG   . PRO   B 2 216 ? -11.38420 -33.53365 -42.69478 1.000 32.34888  ? 1268 PRO   B CG   1 
ATOM   3884 C  CD   . PRO   B 2 216 ? -10.99428 -34.86463 -42.13469 1.000 29.50049  ? 1268 PRO   B CD   1 
ATOM   3885 N  N    . ASN   B 2 217 ? -12.90451 -36.73172 -44.96147 1.000 29.42231  ? 1269 ASN   B N    1 
ATOM   3886 C  CA   . ASN   B 2 217 ? -13.39061 -37.45677 -46.13740 1.000 32.23192  ? 1269 ASN   B CA   1 
ATOM   3887 C  C    . ASN   B 2 217 ? -14.53867 -38.41266 -45.81028 1.000 34.99515  ? 1269 ASN   B C    1 
ATOM   3888 O  O    . ASN   B 2 217 ? -15.11374 -39.00370 -46.73022 1.000 37.53460  ? 1269 ASN   B O    1 
ATOM   3889 C  CB   . ASN   B 2 217 ? -12.23469 -38.21491 -46.80838 1.000 29.89485  ? 1269 ASN   B CB   1 
ATOM   3890 C  CG   . ASN   B 2 217 ? -11.63473 -39.27888 -45.91432 1.000 32.56358  ? 1269 ASN   B CG   1 
ATOM   3891 O  OD1  . ASN   B 2 217 ? -12.30574 -39.83577 -45.04525 1.000 32.26484  ? 1269 ASN   B OD1  1 
ATOM   3892 N  ND2  . ASN   B 2 217 ? -10.35176 -39.55199 -46.11134 1.000 35.08788  ? 1269 ASN   B ND2  1 
ATOM   3893 N  N    . GLY   B 2 218 ? -14.87963 -38.58354 -44.53726 1.000 31.30869  ? 1270 GLY   B N    1 
ATOM   3894 C  CA   . GLY   B 2 218 ? -15.95668 -39.47343 -44.15315 1.000 33.08070  ? 1270 GLY   B CA   1 
ATOM   3895 C  C    . GLY   B 2 218 ? -15.64580 -40.95046 -44.28204 1.000 35.28992  ? 1270 GLY   B C    1 
ATOM   3896 O  O    . GLY   B 2 218 ? -16.54185 -41.77338 -44.08394 1.000 33.87001  ? 1270 GLY   B O    1 
ATOM   3897 N  N    . LEU   B 2 219 ? -14.40283 -41.31758 -44.58306 1.000 30.69145  ? 1271 LEU   B N    1 
ATOM   3898 C  CA   . LEU   B 2 219 ? -14.11195 -42.75262 -44.85895 1.000 38.18557  ? 1271 LEU   B CA   1 
ATOM   3899 C  C    . LEU   B 2 219 ? -13.08696 -43.36662 -43.88794 1.000 36.20675  ? 1271 LEU   B C    1 
ATOM   3900 O  O    . LEU   B 2 219 ? -12.81105 -44.56865 -44.01786 1.000 34.33620  ? 1271 LEU   B O    1 
ATOM   3901 C  CB   . LEU   B 2 219 ? -13.66201 -42.86477 -46.31296 1.000 38.43189  ? 1271 LEU   B CB   1 
ATOM   3902 C  CG   . LEU   B 2 219 ? -14.76903 -42.63877 -47.34494 1.000 40.48385  ? 1271 LEU   B CG   1 
ATOM   3903 C  CD1  . LEU   B 2 219 ? -14.22206 -42.40492 -48.73698 1.000 44.95187  ? 1271 LEU   B CD1  1 
ATOM   3904 C  CD2  . LEU   B 2 219 ? -15.73711 -43.80170 -47.32381 1.000 40.52415  ? 1271 LEU   B CD2  1 
ATOM   3905 N  N    . GLU   B 2 220 ? -12.56787 -42.58758 -42.94702 1.000 31.51777  ? 1272 GLU   B N    1 
ATOM   3906 C  CA   . GLU   B 2 220 ? -11.62587 -43.15157 -41.99501 1.000 32.12087  ? 1272 GLU   B CA   1 
ATOM   3907 C  C    . GLU   B 2 220 ? -11.71877 -42.36746 -40.69607 1.000 32.63205  ? 1272 GLU   B C    1 
ATOM   3908 O  O    . GLU   B 2 220 ? -12.24969 -41.24842 -40.66214 1.000 29.57345  ? 1272 GLU   B O    1 
ATOM   3909 C  CB   . GLU   B 2 220 ? -10.19789 -43.15572 -42.57006 1.000 31.79735  ? 1272 GLU   B CB   1 
ATOM   3910 C  CG   . GLU   B 2 220 ? -9.62281  -41.80279 -42.89719 1.000 32.25705  ? 1272 GLU   B CG   1 
ATOM   3911 C  CD   . GLU   B 2 220 ? -8.57385  -41.86495 -44.02222 1.000 35.29868  ? 1272 GLU   B CD   1 
ATOM   3912 O  OE1  . GLU   B 2 220 ? -8.93192  -42.28402 -45.12818 1.000 38.23994  ? 1272 GLU   B OE1  1 
ATOM   3913 O  OE2  . GLU   B 2 220 ? -7.39982  -41.49302 -43.81129 1.000 33.62879  ? 1272 GLU   B OE2  1 
ATOM   3914 N  N    . VAL   B 2 221 ? -11.22778 -42.98841 -39.61504 1.000 26.79727  ? 1273 VAL   B N    1 
ATOM   3915 C  CA   . VAL   B 2 221 ? -11.12668 -42.32532 -38.32409 1.000 27.39714  ? 1273 VAL   B CA   1 
ATOM   3916 C  C    . VAL   B 2 221 ? -9.67367  -42.33239 -37.88415 1.000 31.40014  ? 1273 VAL   B C    1 
ATOM   3917 O  O    . VAL   B 2 221 ? -8.89274  -43.23347 -38.22210 1.000 30.32627  ? 1273 VAL   B O    1 
ATOM   3918 C  CB   . VAL   B 2 221 ? -12.01569 -42.96417 -37.23201 1.000 26.40904  ? 1273 VAL   B CB   1 
ATOM   3919 C  CG1  . VAL   B 2 221 ? -13.49968 -42.71309 -37.55798 1.000 25.48280  ? 1273 VAL   B CG1  1 
ATOM   3920 C  CG2  . VAL   B 2 221 ? -11.69179 -44.45818 -37.09091 1.000 24.13725  ? 1273 VAL   B CG2  1 
ATOM   3921 N  N    . ILE   B 2 222 ? -9.32557  -41.30235 -37.12624 1.000 26.56553  ? 1274 ILE   B N    1 
ATOM   3922 C  CA   . ILE   B 2 222 ? -7.99053  -41.08041 -36.59030 1.000 26.75188  ? 1274 ILE   B CA   1 
ATOM   3923 C  C    . ILE   B 2 222 ? -8.10849  -41.21428 -35.08529 1.000 29.23037  ? 1274 ILE   B C    1 
ATOM   3924 O  O    . ILE   B 2 222 ? -8.64440  -40.32119 -34.42534 1.000 29.88523  ? 1274 ILE   B O    1 
ATOM   3925 C  CB   . ILE   B 2 222 ? -7.45944  -39.68848 -36.96843 1.000 25.22789  ? 1274 ILE   B CB   1 
ATOM   3926 C  CG1  . ILE   B 2 222 ? -7.52348  -39.48559 -38.48845 1.000 26.90888  ? 1274 ILE   B CG1  1 
ATOM   3927 C  CG2  . ILE   B 2 222 ? -6.05941  -39.48554 -36.42250 1.000 25.96919  ? 1274 ILE   B CG2  1 
ATOM   3928 C  CD1  . ILE   B 2 222 ? -7.63239  -38.04462 -38.92956 1.000 27.34143  ? 1274 ILE   B CD1  1 
ATOM   3929 N  N    . ILE   B 2 223 ? -7.60555  -42.30927 -34.53122 1.000 29.11139  ? 1275 ILE   B N    1 
ATOM   3930 C  CA   . ILE   B 2 223 ? -7.69951  -42.56915 -33.09920 1.000 26.66997  ? 1275 ILE   B CA   1 
ATOM   3931 C  C    . ILE   B 2 223 ? -6.26850  -42.63122 -32.58824 1.000 23.36120  ? 1275 ILE   B C    1 
ATOM   3932 O  O    . ILE   B 2 223 ? -5.63758  -43.69026 -32.58418 1.000 27.82891  ? 1275 ILE   B O    1 
ATOM   3933 C  CB   . ILE   B 2 223 ? -8.46859  -43.85107 -32.78207 1.000 24.40101  ? 1275 ILE   B CB   1 
ATOM   3934 C  CG1  . ILE   B 2 223 ? -9.84062  -43.81803 -33.46702 1.000 28.16740  ? 1275 ILE   B CG1  1 
ATOM   3935 C  CG2  . ILE   B 2 223 ? -8.60055  -44.01994 -31.27405 1.000 28.33820  ? 1275 ILE   B CG2  1 
ATOM   3936 C  CD1  . ILE   B 2 223 ? -10.79068 -44.95492 -33.01990 1.000 31.51216  ? 1275 ILE   B CD1  1 
ATOM   3937 N  N    . ASN   B 2 224 ? -5.74840  -41.48922 -32.15435 1.000 26.07545  ? 1276 ASN   B N    1 
ATOM   3938 C  CA   . ASN   B 2 224 ? -4.38738  -41.40628 -31.62041 1.000 27.01678  ? 1276 ASN   B CA   1 
ATOM   3939 C  C    . ASN   B 2 224 ? -3.46145  -41.79943 -32.76941 1.000 25.28016  ? 1276 ASN   B C    1 
ATOM   3940 O  O    . ASN   B 2 224 ? -3.60344  -41.22651 -33.86045 1.000 27.39993  ? 1276 ASN   B O    1 
ATOM   3941 C  CB   . ASN   B 2 224 ? -4.26639  -42.24918 -30.35935 1.000 26.29454  ? 1276 ASN   B CB   1 
ATOM   3942 C  CG   . ASN   B 2 224 ? -3.08133  -41.84020 -29.51642 1.000 25.33829  ? 1276 ASN   B CG   1 
ATOM   3943 O  OD1  . ASN   B 2 224 ? -2.92924  -40.67219 -29.19552 1.000 27.17594  ? 1276 ASN   B OD1  1 
ATOM   3944 N  ND2  . ASN   B 2 224 ? -2.22539  -42.79824 -29.17137 1.000 28.31477  ? 1276 ASN   B ND2  1 
ATOM   3945 N  N    . THR   B 2 225 ? -2.55651  -42.76849 -32.59237 1.000 26.76537  ? 1277 THR   B N    1 
ATOM   3946 C  CA   . THR   B 2 225 ? -1.61458  -43.19064 -33.63237 1.000 30.32594  ? 1277 THR   B CA   1 
ATOM   3947 C  C    . THR   B 2 225 ? -2.23168  -44.10168 -34.69627 1.000 27.90267  ? 1277 THR   B C    1 
ATOM   3948 O  O    . THR   B 2 225 ? -1.53874  -44.43880 -35.66127 1.000 28.21191  ? 1277 THR   B O    1 
ATOM   3949 C  CB   . THR   B 2 225 ? -0.39961  -43.89867 -32.99935 1.000 26.66515  ? 1277 THR   B CB   1 
ATOM   3950 O  OG1  . THR   B 2 225 ? -0.83666  -45.02058 -32.20525 1.000 26.97522  ? 1277 THR   B OG1  1 
ATOM   3951 C  CG2  . THR   B 2 225 ? 0.37150   -42.93766 -32.10046 1.000 24.78691  ? 1277 THR   B CG2  1 
ATOM   3952 N  N    . GLU   B 2 226 ? -3.50170  -44.48657 -34.58120 1.000 27.82647  ? 1278 GLU   B N    1 
ATOM   3953 C  CA   . GLU   B 2 226 ? -4.11481  -45.46860 -35.47010 1.000 28.47718  ? 1278 GLU   B CA   1 
ATOM   3954 C  C    . GLU   B 2 226 ? -5.05579  -44.78661 -36.45312 1.000 28.87755  ? 1278 GLU   B C    1 
ATOM   3955 O  O    . GLU   B 2 226 ? -5.94172  -44.02951 -36.05014 1.000 28.55812  ? 1278 GLU   B O    1 
ATOM   3956 C  CB   . GLU   B 2 226 ? -4.88886  -46.53548 -34.67498 1.000 28.55309  ? 1278 GLU   B CB   1 
ATOM   3957 C  CG   . GLU   B 2 226 ? -4.02891  -47.64549 -34.02093 1.000 27.41311  ? 1278 GLU   B CG   1 
ATOM   3958 C  CD   . GLU   B 2 226 ? -3.04284  -47.11148 -32.99300 1.000 25.75902  ? 1278 GLU   B CD   1 
ATOM   3959 O  OE1  . GLU   B 2 226 ? -3.46278  -46.82436 -31.85001 1.000 30.04544  ? 1278 GLU   B OE1  1 
ATOM   3960 O  OE2  . GLU   B 2 226 ? -1.85584  -46.96460 -33.33806 1.000 29.28600  ? 1278 GLU   B OE2  1 
ATOM   3961 N  N    . ILE   B 2 227 ? -4.87886  -45.07672 -37.73910 1.000 28.82443  ? 1279 ILE   B N    1 
ATOM   3962 C  CA   . ILE   B 2 227 ? -5.78186  -44.60974 -38.78510 1.000 27.27926  ? 1279 ILE   B CA   1 
ATOM   3963 C  C    . ILE   B 2 227 ? -6.58397  -45.81872 -39.26098 1.000 30.99873  ? 1279 ILE   B C    1 
ATOM   3964 O  O    . ILE   B 2 227 ? -6.03206  -46.73281 -39.88693 1.000 32.80982  ? 1279 ILE   B O    1 
ATOM   3965 C  CB   . ILE   B 2 227 ? -5.02686  -43.94389 -39.94418 1.000 29.88162  ? 1279 ILE   B CB   1 
ATOM   3966 C  CG1  . ILE   B 2 227 ? -4.05576  -42.87092 -39.42230 1.000 31.23093  ? 1279 ILE   B CG1  1 
ATOM   3967 C  CG2  . ILE   B 2 227 ? -6.00785  -43.31089 -40.91320 1.000 28.04691  ? 1279 ILE   B CG2  1 
ATOM   3968 C  CD1  . ILE   B 2 227 ? -4.72265  -41.81780 -38.57936 1.000 31.78819  ? 1279 ILE   B CD1  1 
ATOM   3969 N  N    . TRP   B 2 228 ? -7.87596  -45.83660 -38.95093 1.000 25.39431  ? 1280 TRP   B N    1 
ATOM   3970 C  CA   . TRP   B 2 228 ? -8.75205  -46.96356 -39.25681 1.000 28.99618  ? 1280 TRP   B CA   1 
ATOM   3971 C  C    . TRP   B 2 228 ? -9.66907  -46.66159 -40.43380 1.000 29.52108  ? 1280 TRP   B C    1 
ATOM   3972 O  O    . TRP   B 2 228 ? -10.31100 -45.60655 -40.49286 1.000 29.64057  ? 1280 TRP   B O    1 
ATOM   3973 C  CB   . TRP   B 2 228 ? -9.63904  -47.34041 -38.07175 1.000 27.71880  ? 1280 TRP   B CB   1 
ATOM   3974 C  CG   . TRP   B 2 228 ? -8.95702  -47.72136 -36.81174 1.000 31.90934  ? 1280 TRP   B CG   1 
ATOM   3975 C  CD1  . TRP   B 2 228 ? -8.88592  -46.98427 -35.66781 1.000 27.42877  ? 1280 TRP   B CD1  1 
ATOM   3976 C  CD2  . TRP   B 2 228 ? -8.27910  -48.95538 -36.54167 1.000 35.67086  ? 1280 TRP   B CD2  1 
ATOM   3977 N  NE1  . TRP   B 2 228 ? -8.20494  -47.67824 -34.69678 1.000 29.00733  ? 1280 TRP   B NE1  1 
ATOM   3978 C  CE2  . TRP   B 2 228 ? -7.80805  -48.88631 -35.20969 1.000 32.81605  ? 1280 TRP   B CE2  1 
ATOM   3979 C  CE3  . TRP   B 2 228 ? -8.01321  -50.10646 -37.29959 1.000 33.34902  ? 1280 TRP   B CE3  1 
ATOM   3980 C  CZ2  . TRP   B 2 228 ? -7.09210  -49.92832 -34.61464 1.000 31.03754  ? 1280 TRP   B CZ2  1 
ATOM   3981 C  CZ3  . TRP   B 2 228 ? -7.29426  -51.14347 -36.70653 1.000 37.78924  ? 1280 TRP   B CZ3  1 
ATOM   3982 C  CH2  . TRP   B 2 228 ? -6.84321  -51.04540 -35.37556 1.000 35.89621  ? 1280 TRP   B CH2  1 
ATOM   3983 N  N    . ASP   B 2 229 ? -9.77917  -47.62565 -41.33572 1.000 26.54203  ? 1281 ASP   B N    1 
ATOM   3984 C  CA   . ASP   B 2 229 ? -10.68720 -47.50968 -42.46970 1.000 31.53948  ? 1281 ASP   B CA   1 
ATOM   3985 C  C    . ASP   B 2 229 ? -12.12221 -47.75154 -42.00863 1.000 29.03604  ? 1281 ASP   B C    1 
ATOM   3986 O  O    . ASP   B 2 229 ? -12.39926 -48.76047 -41.35454 1.000 32.76450  ? 1281 ASP   B O    1 
ATOM   3987 C  CB   . ASP   B 2 229 ? -10.28132 -48.52779 -43.53863 1.000 33.11600  ? 1281 ASP   B CB   1 
ATOM   3988 C  CG   . ASP   B 2 229 ? -11.00035 -48.32985 -44.85762 1.000 35.30346  ? 1281 ASP   B CG   1 
ATOM   3989 O  OD1  . ASP   B 2 229 ? -11.97430 -47.56278 -44.93065 1.000 31.09726  ? 1281 ASP   B OD1  1 
ATOM   3990 O  OD2  . ASP   B 2 229 ? -10.57243 -48.95495 -45.83659 1.000 43.25774  ? 1281 ASP   B OD2  1 
ATOM   3991 N  N    . LEU   B 2 230 ? -13.04015 -46.83950 -42.34367 1.000 29.03459  ? 1282 LEU   B N    1 
ATOM   3992 C  CA   . LEU   B 2 230 ? -14.44516 -47.10037 -42.02760 1.000 30.60007  ? 1282 LEU   B CA   1 
ATOM   3993 C  C    . LEU   B 2 230 ? -15.10327 -48.08240 -43.00050 1.000 35.51113  ? 1282 LEU   B C    1 
ATOM   3994 O  O    . LEU   B 2 230 ? -16.17029 -48.62930 -42.68942 1.000 32.80837  ? 1282 LEU   B O    1 
ATOM   3995 C  CB   . LEU   B 2 230 ? -15.26906 -45.80331 -41.99967 1.000 29.62062  ? 1282 LEU   B CB   1 
ATOM   3996 C  CG   . LEU   B 2 230 ? -14.99795 -44.82024 -40.86576 1.000 29.89923  ? 1282 LEU   B CG   1 
ATOM   3997 C  CD1  . LEU   B 2 230 ? -15.76287 -43.52020 -41.07483 1.000 27.21127  ? 1282 LEU   B CD1  1 
ATOM   3998 C  CD2  . LEU   B 2 230 ? -15.35895 -45.45111 -39.51870 1.000 25.34209  ? 1282 LEU   B CD2  1 
ATOM   3999 N  N    . ARG   B 2 231 ? -14.50432 -48.31454 -44.15250 1.000 28.84584  ? 1283 ARG   B N    1 
ATOM   4000 C  CA   . ARG   B 2 231 ? -15.09543 -49.25957 -45.12340 1.000 36.71639  ? 1283 ARG   B CA   1 
ATOM   4001 C  C    . ARG   B 2 231 ? -14.85851 -50.70455 -44.66630 1.000 38.58123  ? 1283 ARG   B C    1 
ATOM   4002 O  O    . ARG   B 2 231 ? -15.74358 -51.53251 -44.90520 1.000 37.92084  ? 1283 ARG   B O    1 
ATOM   4003 C  CB   . ARG   B 2 231 ? -14.48346 -48.99172 -46.50245 1.000 36.11326  ? 1283 ARG   B CB   1 
ATOM   4004 C  CG   . ARG   B 2 231 ? -14.87438 -47.65474 -47.11154 1.000 37.84905  ? 1283 ARG   B CG   1 
ATOM   4005 C  CD   . ARG   B 2 231 ? -14.14441 -47.45390 -48.42158 1.000 47.14767  ? 1283 ARG   B CD   1 
ATOM   4006 N  NE   . ARG   B 2 231 ? -12.70239 -47.29899 -48.21464 1.000 46.08306  ? 1283 ARG   B NE   1 
ATOM   4007 C  CZ   . ARG   B 2 231 ? -12.10931 -46.12402 -48.09376 1.000 45.12987  ? 1283 ARG   B CZ   1 
ATOM   4008 N  NH1  . ARG   B 2 231 ? -12.04628 -45.30911 -49.12783 1.000 47.24384  ? 1283 ARG   B NH1  1 
ATOM   4009 N  NH2  . ARG   B 2 231 ? -11.59224 -45.76097 -46.93881 1.000 47.11496  ? 1283 ARG   B NH2  1 
ATOM   4010 N  N    . THR   B 2 232 ? -13.75251 -50.97458 -43.97932 1.000 35.02589  ? 1284 THR   B N    1 
ATOM   4011 C  CA   . THR   B 2 232 ? -13.34860 -52.33158 -43.63522 1.000 38.89979  ? 1284 THR   B CA   1 
ATOM   4012 C  C    . THR   B 2 232 ? -12.90256 -52.50550 -42.19523 1.000 40.15688  ? 1284 THR   B C    1 
ATOM   4013 O  O    . THR   B 2 232 ? -12.72662 -53.65148 -41.76514 1.000 36.45598  ? 1284 THR   B O    1 
ATOM   4014 C  CB   . THR   B 2 232 ? -12.17366 -52.78273 -44.51423 1.000 39.42261  ? 1284 THR   B CB   1 
ATOM   4015 O  OG1  . THR   B 2 232 ? -11.06359 -51.91679 -44.26434 1.000 33.61381  ? 1284 THR   B OG1  1 
ATOM   4016 C  CG2  . THR   B 2 232 ? -12.54071 -52.76483 -46.01322 1.000 32.54177  ? 1284 THR   B CG2  1 
ATOM   4017 N  N    . PHE   B 2 233 ? -12.65045 -51.41946 -41.46432 1.000 36.29906  ? 1285 PHE   B N    1 
ATOM   4018 C  CA   . PHE   B 2 233 ? -12.04141 -51.45940 -40.13434 1.000 33.13676  ? 1285 PHE   B CA   1 
ATOM   4019 C  C    . PHE   B 2 233 ? -10.61145 -51.99850 -40.15835 1.000 30.60778  ? 1285 PHE   B C    1 
ATOM   4020 O  O    . PHE   B 2 233 ? -10.07443 -52.32846 -39.11134 1.000 35.82385  ? 1285 PHE   B O    1 
ATOM   4021 C  CB   . PHE   B 2 233 ? -12.88643 -52.26726 -39.14725 1.000 36.41239  ? 1285 PHE   B CB   1 
ATOM   4022 C  CG   . PHE   B 2 233 ? -14.32540 -51.84615 -39.10123 1.000 34.89970  ? 1285 PHE   B CG   1 
ATOM   4023 C  CD1  . PHE   B 2 233 ? -14.68429 -50.60608 -38.61331 1.000 36.48977  ? 1285 PHE   B CD1  1 
ATOM   4024 C  CD2  . PHE   B 2 233 ? -15.32248 -52.69211 -39.55712 1.000 40.53070  ? 1285 PHE   B CD2  1 
ATOM   4025 C  CE1  . PHE   B 2 233 ? -16.02526 -50.21498 -38.57330 1.000 32.93138  ? 1285 PHE   B CE1  1 
ATOM   4026 C  CE2  . PHE   B 2 233 ? -16.66345 -52.30501 -39.51911 1.000 43.56288  ? 1285 PHE   B CE2  1 
ATOM   4027 C  CZ   . PHE   B 2 233 ? -17.00834 -51.06995 -39.02419 1.000 37.78461  ? 1285 PHE   B CZ   1 
ATOM   4028 N  N    . HIS   B 2 234 ? -9.96649  -52.06864 -41.32537 1.000 31.86665  ? 1286 HIS   B N    1 
ATOM   4029 C  CA   . HIS   B 2 234 ? -8.53852  -52.36475 -41.35039 1.000 31.99072  ? 1286 HIS   B CA   1 
ATOM   4030 C  C    . HIS   B 2 234 ? -7.72641  -51.16177 -40.89352 1.000 32.59411  ? 1286 HIS   B C    1 
ATOM   4031 O  O    . HIS   B 2 234 ? -8.18933  -50.02374 -40.92359 1.000 32.75339  ? 1286 HIS   B O    1 
ATOM   4032 C  CB   . HIS   B 2 234 ? -8.08359  -52.75589 -42.75638 1.000 35.11807  ? 1286 HIS   B CB   1 
ATOM   4033 C  CG   . HIS   B 2 234 ? -8.63371  -54.06589 -43.23225 1.000 39.34750  ? 1286 HIS   B CG   1 
ATOM   4034 N  ND1  . HIS   B 2 234 ? -8.22879  -54.65701 -44.41122 1.000 40.76927  ? 1286 HIS   B ND1  1 
ATOM   4035 C  CD2  . HIS   B 2 234 ? -9.55275  -54.90178 -42.68616 1.000 37.66899  ? 1286 HIS   B CD2  1 
ATOM   4036 C  CE1  . HIS   B 2 234 ? -8.88488  -55.79298 -44.57611 1.000 42.18841  ? 1286 HIS   B CE1  1 
ATOM   4037 N  NE2  . HIS   B 2 234 ? -9.68685  -55.97084 -43.53907 1.000 44.57718  ? 1286 HIS   B NE2  1 
ATOM   4038 N  N    . LEU   B 2 235 ? -6.48142  -51.42383 -40.50054 1.000 31.46125  ? 1287 LEU   B N    1 
ATOM   4039 C  CA   . LEU   B 2 235 ? -5.53933  -50.37587 -40.12566 1.000 29.00804  ? 1287 LEU   B CA   1 
ATOM   4040 C  C    . LEU   B 2 235 ? -4.88733  -49.81601 -41.38472 1.000 36.27956  ? 1287 LEU   B C    1 
ATOM   4041 O  O    . LEU   B 2 235 ? -4.08641  -50.50212 -42.03670 1.000 32.32887  ? 1287 LEU   B O    1 
ATOM   4042 C  CB   . LEU   B 2 235 ? -4.48433  -50.92087 -39.16765 1.000 28.88363  ? 1287 LEU   B CB   1 
ATOM   4043 C  CG   . LEU   B 2 235 ? -3.48224  -49.90290 -38.62077 1.000 31.44302  ? 1287 LEU   B CG   1 
ATOM   4044 C  CD1  . LEU   B 2 235 ? -4.16314  -48.89877 -37.70282 1.000 28.39649  ? 1287 LEU   B CD1  1 
ATOM   4045 C  CD2  . LEU   B 2 235 ? -2.35226  -50.60492 -37.87775 1.000 23.27975  ? 1287 LEU   B CD2  1 
ATOM   4046 N  N    . LEU   B 2 236 ? -5.20325  -48.55902 -41.71181 1.000 31.66594  ? 1288 LEU   B N    1 
ATOM   4047 C  CA   . LEU   B 2 236 ? -4.60025  -47.91615 -42.87189 1.000 32.88970  ? 1288 LEU   B CA   1 
ATOM   4048 C  C    . LEU   B 2 236 ? -3.19620  -47.40023 -42.57898 1.000 32.29303  ? 1288 LEU   B C    1 
ATOM   4049 O  O    . LEU   B 2 236 ? -2.30924  -47.52536 -43.42700 1.000 31.09110  ? 1288 LEU   B O    1 
ATOM   4050 C  CB   . LEU   B 2 236 ? -5.47518  -46.75713 -43.35995 1.000 28.44309  ? 1288 LEU   B CB   1 
ATOM   4051 C  CG   . LEU   B 2 236 ? -6.88423  -47.14706 -43.79786 1.000 36.82475  ? 1288 LEU   B CG   1 
ATOM   4052 C  CD1  . LEU   B 2 236 ? -7.64916  -45.93404 -44.27893 1.000 31.12731  ? 1288 LEU   B CD1  1 
ATOM   4053 C  CD2  . LEU   B 2 236 ? -6.80734  -48.19915 -44.88878 1.000 32.68707  ? 1288 LEU   B CD2  1 
ATOM   4054 N  N    . HIS   B 2 237 ? -2.97811  -46.77015 -41.42003 1.000 32.32052  ? 1289 HIS   B N    1 
ATOM   4055 C  CA   . HIS   B 2 237 ? -1.68606  -46.15122 -41.14113 1.000 29.06317  ? 1289 HIS   B CA   1 
ATOM   4056 C  C    . HIS   B 2 237 ? -1.38901  -46.20913 -39.65513 1.000 31.34153  ? 1289 HIS   B C    1 
ATOM   4057 O  O    . HIS   B 2 237 ? -2.29898  -46.17600 -38.81810 1.000 29.08077  ? 1289 HIS   B O    1 
ATOM   4058 C  CB   . HIS   B 2 237 ? -1.60797  -44.67426 -41.57325 1.000 30.56714  ? 1289 HIS   B CB   1 
ATOM   4059 C  CG   . HIS   B 2 237 ? -1.74500  -44.45937 -43.04426 1.000 29.29253  ? 1289 HIS   B CG   1 
ATOM   4060 N  ND1  . HIS   B 2 237 ? -2.94500  -44.13633 -43.64124 1.000 34.10910  ? 1289 HIS   B ND1  1 
ATOM   4061 C  CD2  . HIS   B 2 237 ? -0.83405  -44.53252 -44.04329 1.000 36.79651  ? 1289 HIS   B CD2  1 
ATOM   4062 C  CE1  . HIS   B 2 237 ? -2.76904  -44.03145 -44.94826 1.000 31.93201  ? 1289 HIS   B CE1  1 
ATOM   4063 N  NE2  . HIS   B 2 237 ? -1.49807  -44.26156 -45.21528 1.000 37.30553  ? 1289 HIS   B NE2  1 
ATOM   4064 N  N    . THR   B 2 238 ? -0.10101  -46.29420 -39.35017 1.000 28.06750  ? 1290 THR   B N    1 
ATOM   4065 C  CA   . THR   B 2 238 ? 0.44806   -46.01813 -38.03222 1.000 30.65357  ? 1290 THR   B CA   1 
ATOM   4066 C  C    . THR   B 2 238 ? 1.16015   -44.68319 -38.12335 1.000 30.88111  ? 1290 THR   B C    1 
ATOM   4067 O  O    . THR   B 2 238 ? 2.10214   -44.54332 -38.90039 1.000 29.52271  ? 1290 THR   B O    1 
ATOM   4068 C  CB   . THR   B 2 238 ? 1.43100   -47.10717 -37.59516 1.000 34.04803  ? 1290 THR   B CB   1 
ATOM   4069 O  OG1  . THR   B 2 238 ? 0.77391   -48.38512 -37.58904 1.000 31.26623  ? 1290 THR   B OG1  1 
ATOM   4070 C  CG2  . THR   B 2 238 ? 1.98007   -46.81110 -36.20321 1.000 29.13117  ? 1290 THR   B CG2  1 
ATOM   4071 N  N    . VAL   B 2 239 ? 0.71325   -43.70910 -37.33541 1.000 30.60747  ? 1291 VAL   B N    1 
ATOM   4072 C  CA   . VAL   B 2 239 ? 1.29235   -42.36814 -37.38253 1.000 31.10631  ? 1291 VAL   B CA   1 
ATOM   4073 C  C    . VAL   B 2 239 ? 1.79242   -42.02307 -35.98558 1.000 29.99061  ? 1291 VAL   B C    1 
ATOM   4074 O  O    . VAL   B 2 239 ? 1.04750   -41.42595 -35.18760 1.000 28.61699  ? 1291 VAL   B O    1 
ATOM   4075 C  CB   . VAL   B 2 239 ? 0.27641   -41.33211 -37.88858 1.000 30.33170  ? 1291 VAL   B CB   1 
ATOM   4076 C  CG1  . VAL   B 2 239 ? 0.95550   -39.96717 -38.05571 1.000 32.62230  ? 1291 VAL   B CG1  1 
ATOM   4077 C  CG2  . VAL   B 2 239 ? -0.35267  -41.78917 -39.19252 1.000 32.32197  ? 1291 VAL   B CG2  1 
ATOM   4078 N  N    . PRO   B 2 240 ? 3.02241   -42.40413 -35.63859 1.000 32.14106  ? 1292 PRO   B N    1 
ATOM   4079 C  CA   . PRO   B 2 240 ? 3.47247   -42.24205 -34.24762 1.000 31.19920  ? 1292 PRO   B CA   1 
ATOM   4080 C  C    . PRO   B 2 240 ? 3.46559   -40.80802 -33.78374 1.000 30.74344  ? 1292 PRO   B C    1 
ATOM   4081 O  O    . PRO   B 2 240 ? 3.28665   -40.56591 -32.58475 1.000 27.61611  ? 1292 PRO   B O    1 
ATOM   4082 C  CB   . PRO   B 2 240 ? 4.90243   -42.80916 -34.26763 1.000 33.37112  ? 1292 PRO   B CB   1 
ATOM   4083 C  CG   . PRO   B 2 240 ? 4.89632   -43.79825 -35.38155 1.000 32.67580  ? 1292 PRO   B CG   1 
ATOM   4084 C  CD   . PRO   B 2 240 ? 3.96832   -43.20226 -36.44156 1.000 32.69764  ? 1292 PRO   B CD   1 
ATOM   4085 N  N    . ALA   B 2 241 ? 3.66563   -39.84810 -34.69582 1.000 28.04421  ? 1293 ALA   B N    1 
ATOM   4086 C  CA   . ALA   B 2 241 ? 3.71574   -38.44407 -34.30593 1.000 32.81959  ? 1293 ALA   B CA   1 
ATOM   4087 C  C    . ALA   B 2 241 ? 2.36780   -37.91894 -33.82792 1.000 31.53807  ? 1293 ALA   B C    1 
ATOM   4088 O  O    . ALA   B 2 241 ? 2.31790   -36.81989 -33.27701 1.000 35.34367  ? 1293 ALA   B O    1 
ATOM   4089 C  CB   . ALA   B 2 241 ? 4.22276   -37.58620 -35.47102 1.000 31.23462  ? 1293 ALA   B CB   1 
ATOM   4090 N  N    . LEU   B 2 242 ? 1.28574   -38.67288 -34.01183 1.000 27.10077  ? 1294 LEU   B N    1 
ATOM   4091 C  CA   . LEU   B 2 242 ? -0.03722  -38.24975 -33.58381 1.000 26.14160  ? 1294 LEU   B CA   1 
ATOM   4092 C  C    . LEU   B 2 242 ? -0.36120  -38.67061 -32.16177 1.000 28.98973  ? 1294 LEU   B C    1 
ATOM   4093 O  O    . LEU   B 2 242 ? -1.49717  -38.45849 -31.70774 1.000 29.96747  ? 1294 LEU   B O    1 
ATOM   4094 C  CB   . LEU   B 2 242 ? -1.09429  -38.79075 -34.54373 1.000 27.31122  ? 1294 LEU   B CB   1 
ATOM   4095 C  CG   . LEU   B 2 242 ? -1.14329  -38.08685 -35.89879 1.000 27.46521  ? 1294 LEU   B CG   1 
ATOM   4096 C  CD1  . LEU   B 2 242 ? -2.16637  -38.76184 -36.77970 1.000 24.58089  ? 1294 LEU   B CD1  1 
ATOM   4097 C  CD2  . LEU   B 2 242 ? -1.47218  -36.61081 -35.73689 1.000 30.36797  ? 1294 LEU   B CD2  1 
ATOM   4098 N  N    . ASP   B 2 243 ? 0.58978   -39.27162 -31.45075 1.000 28.15941  ? 1295 ASP   B N    1 
ATOM   4099 C  CA   . ASP   B 2 243 ? 0.29380   -39.77850 -30.12070 1.000 27.57340  ? 1295 ASP   B CA   1 
ATOM   4100 C  C    . ASP   B 2 243 ? -0.04109  -38.63040 -29.17778 1.000 26.63024  ? 1295 ASP   B C    1 
ATOM   4101 O  O    . ASP   B 2 243 ? 0.72999   -37.67844 -29.04389 1.000 28.59533  ? 1295 ASP   B O    1 
ATOM   4102 C  CB   . ASP   B 2 243 ? 1.46676   -40.58354 -29.56368 1.000 26.78114  ? 1295 ASP   B CB   1 
ATOM   4103 C  CG   . ASP   B 2 243 ? 1.19077   -41.10741 -28.16963 1.000 30.32732  ? 1295 ASP   B CG   1 
ATOM   4104 O  OD1  . ASP   B 2 243 ? 0.06574   -41.63131 -27.92655 1.000 28.76178  ? 1295 ASP   B OD1  1 
ATOM   4105 O  OD2  . ASP   B 2 243 ? 2.08081   -40.97640 -27.30967 1.000 29.62306  ? 1295 ASP   B OD2  1 
ATOM   4106 N  N    . GLN   B 2 244 ? -1.18907  -38.72626 -28.50773 1.000 25.60816  ? 1296 GLN   B N    1 
ATOM   4107 C  CA   . GLN   B 2 244 ? -1.63596  -37.69915 -27.55780 1.000 29.58411  ? 1296 GLN   B CA   1 
ATOM   4108 C  C    . GLN   B 2 244 ? -1.93389  -36.35419 -28.23489 1.000 28.47156  ? 1296 GLN   B C    1 
ATOM   4109 O  O    . GLN   B 2 244 ? -1.87679  -35.29814 -27.59298 1.000 30.80269  ? 1296 GLN   B O    1 
ATOM   4110 C  CB   . GLN   B 2 244 ? -0.61191  -37.51814 -26.43185 1.000 28.65755  ? 1296 GLN   B CB   1 
ATOM   4111 C  CG   . GLN   B 2 244 ? -0.33597  -38.80510 -25.64376 1.000 28.40659  ? 1296 GLN   B CG   1 
ATOM   4112 C  CD   . GLN   B 2 244 ? -1.63101  -39.50297 -25.21666 1.000 30.39439  ? 1296 GLN   B CD   1 
ATOM   4113 O  OE1  . GLN   B 2 244 ? -2.38894  -38.97985 -24.39167 1.000 27.34076  ? 1296 GLN   B OE1  1 
ATOM   4114 N  NE2  . GLN   B 2 244 ? -1.89712  -40.67800 -25.79455 1.000 26.83901  ? 1296 GLN   B NE2  1 
ATOM   4115 N  N    . CYS   B 2 245 ? -2.27494  -36.37426 -29.52188 1.000 26.74650  ? 1297 CYS   B N    1 
ATOM   4116 C  CA   . CYS   B 2 245 ? -2.48788  -35.16131 -30.29297 1.000 27.00378  ? 1297 CYS   B CA   1 
ATOM   4117 C  C    . CYS   B 2 245 ? -3.96386  -34.86322 -30.46294 1.000 25.44115  ? 1297 CYS   B C    1 
ATOM   4118 O  O    . CYS   B 2 245 ? -4.78793  -35.76917 -30.62384 1.000 29.26639  ? 1297 CYS   B O    1 
ATOM   4119 C  CB   . CYS   B 2 245 ? -1.84493  -35.24946 -31.67499 1.000 28.01187  ? 1297 CYS   B CB   1 
ATOM   4120 S  SG   . CYS   B 2 245 ? -0.07991  -34.97659 -31.68907 1.000 27.12295  ? 1297 CYS   B SG   1 
ATOM   4121 N  N    . ARG   B 2 246 ? -4.28277  -33.58119 -30.40703 1.000 24.20011  ? 1298 ARG   B N    1 
ATOM   4122 C  CA   . ARG   B 2 246 ? -5.51375  -33.06014 -30.96503 1.000 25.96890  ? 1298 ARG   B CA   1 
ATOM   4123 C  C    . ARG   B 2 246 ? -5.19676  -32.57728 -32.36908 1.000 28.24223  ? 1298 ARG   B C    1 
ATOM   4124 O  O    . ARG   B 2 246 ? -4.06875  -32.17138 -32.65715 1.000 27.43277  ? 1298 ARG   B O    1 
ATOM   4125 C  CB   . ARG   B 2 246 ? -6.07864  -31.92903 -30.09210 1.000 26.96600  ? 1298 ARG   B CB   1 
ATOM   4126 C  CG   . ARG   B 2 246 ? -6.67262  -32.43088 -28.75604 1.000 29.33357  ? 1298 ARG   B CG   1 
ATOM   4127 C  CD   . ARG   B 2 246 ? -8.09667  -32.99680 -28.93394 1.000 24.26873  ? 1298 ARG   B CD   1 
ATOM   4128 N  NE   . ARG   B 2 246 ? -9.02061  -31.92676 -29.27399 1.000 22.87912  ? 1298 ARG   B NE   1 
ATOM   4129 C  CZ   . ARG   B 2 246 ? -10.30563 -32.07369 -29.57393 1.000 28.32295  ? 1298 ARG   B CZ   1 
ATOM   4130 N  NH1  . ARG   B 2 246 ? -10.88271 -33.26564 -29.58282 1.000 30.17057  ? 1298 ARG   B NH1  1 
ATOM   4131 N  NH2  . ARG   B 2 246 ? -11.03556 -30.99266 -29.87199 1.000 24.14759  ? 1298 ARG   B NH2  1 
ATOM   4132 N  N    . VAL   B 2 247 ? -6.16880  -32.69628 -33.26503 1.000 25.17722  ? 1299 VAL   B N    1 
ATOM   4133 C  CA   . VAL   B 2 247 ? -5.94883  -32.33340 -34.65707 1.000 29.46614  ? 1299 VAL   B CA   1 
ATOM   4134 C  C    . VAL   B 2 247 ? -7.07578  -31.43236 -35.12910 1.000 27.91775  ? 1299 VAL   B C    1 
ATOM   4135 O  O    . VAL   B 2 247 ? -8.18776  -31.46124 -34.60306 1.000 29.03247  ? 1299 VAL   B O    1 
ATOM   4136 C  CB   . VAL   B 2 247 ? -5.84295  -33.57148 -35.58198 1.000 28.26332  ? 1299 VAL   B CB   1 
ATOM   4137 C  CG1  . VAL   B 2 247 ? -4.68800  -34.47353 -35.14895 1.000 27.96667  ? 1299 VAL   B CG1  1 
ATOM   4138 C  CG2  . VAL   B 2 247 ? -7.14701  -34.34539 -35.59287 1.000 27.67911  ? 1299 VAL   B CG2  1 
ATOM   4139 N  N    . VAL   B 2 248 ? -6.77076  -30.63746 -36.15517 1.000 30.61922  ? 1300 VAL   B N    1 
ATOM   4140 C  CA   . VAL   B 2 248 ? -7.77573  -29.87845 -36.88820 1.000 24.65722  ? 1300 VAL   B CA   1 
ATOM   4141 C  C    . VAL   B 2 248 ? -7.30678  -29.78860 -38.33622 1.000 31.02098  ? 1300 VAL   B C    1 
ATOM   4142 O  O    . VAL   B 2 248 ? -6.10679  -29.78971 -38.62027 1.000 31.31910  ? 1300 VAL   B O    1 
ATOM   4143 C  CB   . VAL   B 2 248 ? -8.01161  -28.48238 -36.23930 1.000 28.78119  ? 1300 VAL   B CB   1 
ATOM   4144 C  CG1  . VAL   B 2 248 ? -6.76655  -27.60748 -36.34441 1.000 27.34557  ? 1300 VAL   B CG1  1 
ATOM   4145 C  CG2  . VAL   B 2 248 ? -9.22058  -27.78234 -36.85431 1.000 29.16300  ? 1300 VAL   B CG2  1 
ATOM   4146 N  N    . PHE   B 2 249 ? -8.25981  -29.75860 -39.26019 1.000 29.46474  ? 1301 PHE   B N    1 
ATOM   4147 C  CA   . PHE   B 2 249 ? -7.95086  -29.74674 -40.68620 1.000 33.70835  ? 1301 PHE   B CA   1 
ATOM   4148 C  C    . PHE   B 2 249 ? -8.15878  -28.34777 -41.25531 1.000 33.94108  ? 1301 PHE   B C    1 
ATOM   4149 O  O    . PHE   B 2 249 ? -8.94970  -27.56467 -40.72734 1.000 31.87916  ? 1301 PHE   B O    1 
ATOM   4150 C  CB   . PHE   B 2 249 ? -8.82796  -30.75173 -41.44709 1.000 31.82319  ? 1301 PHE   B CB   1 
ATOM   4151 C  CG   . PHE   B 2 249 ? -8.57905  -32.19672 -41.05799 1.000 32.74515  ? 1301 PHE   B CG   1 
ATOM   4152 C  CD1  . PHE   B 2 249 ? -9.07304  -32.70759 -39.85693 1.000 32.90759  ? 1301 PHE   B CD1  1 
ATOM   4153 C  CD2  . PHE   B 2 249 ? -7.85014  -33.04584 -41.88695 1.000 33.94887  ? 1301 PHE   B CD2  1 
ATOM   4154 C  CE1  . PHE   B 2 249 ? -8.85512  -34.02258 -39.50983 1.000 30.03484  ? 1301 PHE   B CE1  1 
ATOM   4155 C  CE2  . PHE   B 2 249 ? -7.64022  -34.37783 -41.53485 1.000 29.22679  ? 1301 PHE   B CE2  1 
ATOM   4156 C  CZ   . PHE   B 2 249 ? -8.13121  -34.85270 -40.34679 1.000 29.70985  ? 1301 PHE   B CZ   1 
ATOM   4157 N  N    . ASN   B 2 250 ? -7.43079  -28.02890 -42.32736 1.000 31.22102  ? 1302 ASN   B N    1 
ATOM   4158 C  CA   . ASN   B 2 250 ? -7.82574  -26.87394 -43.11143 1.000 33.85371  ? 1302 ASN   B CA   1 
ATOM   4159 C  C    . ASN   B 2 250 ? -9.18078  -27.15789 -43.73836 1.000 37.15665  ? 1302 ASN   B C    1 
ATOM   4160 O  O    . ASN   B 2 250 ? -9.67086  -28.28985 -43.74426 1.000 34.02707  ? 1302 ASN   B O    1 
ATOM   4161 C  CB   . ASN   B 2 250 ? -6.78175  -26.54010 -44.17550 1.000 34.76608  ? 1302 ASN   B CB   1 
ATOM   4162 C  CG   . ASN   B 2 250 ? -6.62687  -27.63819 -45.23442 1.000 39.50151  ? 1302 ASN   B CG   1 
ATOM   4163 O  OD1  . ASN   B 2 250 ? -7.43494  -28.57014 -45.32631 1.000 39.05937  ? 1302 ASN   B OD1  1 
ATOM   4164 N  ND2  . ASN   B 2 250 ? -5.57689  -27.52133 -46.04146 1.000 39.06938  ? 1302 ASN   B ND2  1 
ATOM   4165 N  N    . HIS   B 2 251 ? -9.80272  -26.10988 -44.25542 1.000 34.12492  ? 1303 HIS   B N    1 
ATOM   4166 C  CA   . HIS   B 2 251 ? -11.20074 -26.23081 -44.63937 1.000 34.91367  ? 1303 HIS   B CA   1 
ATOM   4167 C  C    . HIS   B 2 251 ? -11.39584 -26.97490 -45.95630 1.000 37.10762  ? 1303 HIS   B C    1 
ATOM   4168 O  O    . HIS   B 2 251 ? -12.53488 -27.32385 -46.28123 1.000 38.15963  ? 1303 HIS   B O    1 
ATOM   4169 C  CB   . HIS   B 2 251 ? -11.84364 -24.83477 -44.66745 1.000 39.17186  ? 1303 HIS   B CB   1 
ATOM   4170 C  CG   . HIS   B 2 251 ? -11.93655 -24.20765 -43.30550 1.000 40.45962  ? 1303 HIS   B CG   1 
ATOM   4171 N  ND1  . HIS   B 2 251 ? -10.84849 -23.64868 -42.66558 1.000 37.73755  ? 1303 HIS   B ND1  1 
ATOM   4172 C  CD2  . HIS   B 2 251 ? -12.96951 -24.11251 -42.43247 1.000 39.86218  ? 1303 HIS   B CD2  1 
ATOM   4173 C  CE1  . HIS   B 2 251 ? -11.21241 -23.21056 -41.47260 1.000 38.19745  ? 1303 HIS   B CE1  1 
ATOM   4174 N  NE2  . HIS   B 2 251 ? -12.49443 -23.48446 -41.30354 1.000 41.29656  ? 1303 HIS   B NE2  1 
ATOM   4175 N  N    . THR   B 2 252 ? -10.32389 -27.26804 -46.69831 1.000 38.13816  ? 1304 THR   B N    1 
ATOM   4176 C  CA   . THR   B 2 252 ? -10.41100 -28.16712 -47.84924 1.000 41.38371  ? 1304 THR   B CA   1 
ATOM   4177 C  C    . THR   B 2 252 ? -10.14609 -29.62812 -47.49413 1.000 44.15346  ? 1304 THR   B C    1 
ATOM   4178 O  O    . THR   B 2 252 ? -10.32418 -30.50217 -48.34806 1.000 46.04443  ? 1304 THR   B O    1 
ATOM   4179 C  CB   . THR   B 2 252 ? -9.42901  -27.74528 -48.94831 1.000 37.36140  ? 1304 THR   B CB   1 
ATOM   4180 O  OG1  . THR   B 2 252 ? -8.12097  -27.55333 -48.38737 1.000 40.98715  ? 1304 THR   B OG1  1 
ATOM   4181 C  CG2  . THR   B 2 252 ? -9.89894  -26.46930 -49.61639 1.000 39.80379  ? 1304 THR   B CG2  1 
ATOM   4182 N  N    . GLY   B 2 253 ? -9.72907  -29.92705 -46.26813 1.000 39.40275  ? 1305 GLY   B N    1 
ATOM   4183 C  CA   . GLY   B 2 253 ? -9.47016  -31.31004 -45.93303 1.000 35.96426  ? 1305 GLY   B CA   1 
ATOM   4184 C  C    . GLY   B 2 253 ? -8.19222  -31.86218 -46.51403 1.000 35.75693  ? 1305 GLY   B C    1 
ATOM   4185 O  O    . GLY   B 2 253 ? -8.05131  -33.07820 -46.62794 1.000 43.36109  ? 1305 GLY   B O    1 
ATOM   4186 N  N    . THR   B 2 254 ? -7.24617  -31.00128 -46.88113 1.000 36.53535  ? 1306 THR   B N    1 
ATOM   4187 C  CA   . THR   B 2 254 ? -5.99522  -31.44341 -47.47114 1.000 37.82115  ? 1306 THR   B CA   1 
ATOM   4188 C  C    . THR   B 2 254 ? -4.80818  -31.37143 -46.53019 1.000 35.56392  ? 1306 THR   B C    1 
ATOM   4189 O  O    . THR   B 2 254 ? -3.77724  -31.98652 -46.81717 1.000 35.10278  ? 1306 THR   B O    1 
ATOM   4190 C  CB   . THR   B 2 254 ? -5.66820  -30.60454 -48.71622 1.000 37.32767  ? 1306 THR   B CB   1 
ATOM   4191 O  OG1  . THR   B 2 254 ? -5.54609  -29.22651 -48.33233 1.000 39.12730  ? 1306 THR   B OG1  1 
ATOM   4192 C  CG2  . THR   B 2 254 ? -6.78125  -30.75254 -49.76217 1.000 37.12802  ? 1306 THR   B CG2  1 
ATOM   4193 N  N    . VAL   B 2 255 ? -4.91009  -30.62333 -45.44824 1.000 33.47100  ? 1307 VAL   B N    1 
ATOM   4194 C  CA   . VAL   B 2 255 ? -3.83505  -30.49433 -44.47829 1.000 30.62322  ? 1307 VAL   B CA   1 
ATOM   4195 C  C    . VAL   B 2 255 ? -4.42101  -30.67918 -43.08626 1.000 34.86316  ? 1307 VAL   B C    1 
ATOM   4196 O  O    . VAL   B 2 255 ? -5.53997  -30.23508 -42.81025 1.000 30.12999  ? 1307 VAL   B O    1 
ATOM   4197 C  CB   . VAL   B 2 255 ? -3.12795  -29.13739 -44.59842 1.000 34.39925  ? 1307 VAL   B CB   1 
ATOM   4198 C  CG1  . VAL   B 2 255 ? -2.02391  -29.04239 -43.55747 1.000 34.46540  ? 1307 VAL   B CG1  1 
ATOM   4199 C  CG2  . VAL   B 2 255 ? -2.55199  -28.98155 -45.99246 1.000 36.29055  ? 1307 VAL   B CG2  1 
ATOM   4200 N  N    . MET   B 2 256 ? -3.66603  -31.34117 -42.21723 1.000 31.19914  ? 1308 MET   B N    1 
ATOM   4201 C  CA   . MET   B 2 256 ? -4.06100  -31.60703 -40.84419 1.000 33.93773  ? 1308 MET   B CA   1 
ATOM   4202 C  C    . MET   B 2 256 ? -3.01792  -31.01003 -39.91528 1.000 31.11157  ? 1308 MET   B C    1 
ATOM   4203 O  O    . MET   B 2 256 ? -1.81494  -31.24813 -40.09730 1.000 29.25923  ? 1308 MET   B O    1 
ATOM   4204 C  CB   . MET   B 2 256 ? -4.18410  -33.10900 -40.58807 1.000 31.47449  ? 1308 MET   B CB   1 
ATOM   4205 C  CG   . MET   B 2 256 ? -4.84807  -33.45685 -39.27302 1.000 30.13967  ? 1308 MET   B CG   1 
ATOM   4206 S  SD   . MET   B 2 256 ? -4.94120  -35.26182 -39.02287 1.000 34.32530  ? 1308 MET   B SD   1 
ATOM   4207 C  CE   . MET   B 2 256 ? -3.25320  -35.59291 -38.58491 1.000 28.01213  ? 1308 MET   B CE   1 
ATOM   4208 N  N    . TYR   B 2 257 ? -3.47683  -30.22992 -38.93532 1.000 29.72592  ? 1309 TYR   B N    1 
ATOM   4209 C  CA   . TYR   B 2 257 ? -2.61575  -29.69890 -37.87740 1.000 31.08054  ? 1309 TYR   B CA   1 
ATOM   4210 C  C    . TYR   B 2 257 ? -2.72577  -30.57879 -36.64132 1.000 32.28618  ? 1309 TYR   B C    1 
ATOM   4211 O  O    . TYR   B 2 257 ? -3.82979  -30.96168 -36.23725 1.000 33.09038  ? 1309 TYR   B O    1 
ATOM   4212 C  CB   . TYR   B 2 257 ? -3.00464  -28.26684 -37.48350 1.000 32.20075  ? 1309 TYR   B CB   1 
ATOM   4213 C  CG   . TYR   B 2 257 ? -2.87760  -27.25494 -38.59358 1.000 32.98431  ? 1309 TYR   B CG   1 
ATOM   4214 C  CD1  . TYR   B 2 257 ? -3.81063  -27.20695 -39.62655 1.000 32.49653  ? 1309 TYR   B CD1  1 
ATOM   4215 C  CD2  . TYR   B 2 257 ? -1.84653  -26.32401 -38.59269 1.000 33.47863  ? 1309 TYR   B CD2  1 
ATOM   4216 C  CE1  . TYR   B 2 257 ? -3.70160  -26.26904 -40.65163 1.000 31.47054  ? 1309 TYR   B CE1  1 
ATOM   4217 C  CE2  . TYR   B 2 257 ? -1.73150  -25.38210 -39.60877 1.000 31.98047  ? 1309 TYR   B CE2  1 
ATOM   4218 C  CZ   . TYR   B 2 257 ? -2.65454  -25.35911 -40.62974 1.000 33.76077  ? 1309 TYR   B CZ   1 
ATOM   4219 O  OH   . TYR   B 2 257 ? -2.54351  -24.42820 -41.64682 1.000 34.74144  ? 1309 TYR   B OH   1 
ATOM   4220 N  N    . GLY   B 2 258 ? -1.57477  -30.87783 -36.03534 1.000 28.52994  ? 1310 GLY   B N    1 
ATOM   4221 C  CA   . GLY   B 2 258 ? -1.52679  -31.70374 -34.85228 1.000 29.84317  ? 1310 GLY   B CA   1 
ATOM   4222 C  C    . GLY   B 2 258 ? -0.63471  -31.13572 -33.77035 1.000 31.47338  ? 1310 GLY   B C    1 
ATOM   4223 O  O    . GLY   B 2 258 ? 0.51331   -30.76482 -34.04042 1.000 36.15531  ? 1310 GLY   B O    1 
ATOM   4224 N  N    . ALA   B 2 259 ? -1.13666  -31.05258 -32.54234 1.000 29.79030  ? 1311 ALA   B N    1 
ATOM   4225 C  CA   . ALA   B 2 259 ? -0.30959  -30.67055 -31.40040 1.000 29.53853  ? 1311 ALA   B CA   1 
ATOM   4226 C  C    . ALA   B 2 259 ? -0.51362  -31.66645 -30.26532 1.000 30.57237  ? 1311 ALA   B C    1 
ATOM   4227 O  O    . ALA   B 2 259 ? -1.63165  -32.16035 -30.04224 1.000 27.21802  ? 1311 ALA   B O    1 
ATOM   4228 C  CB   . ALA   B 2 259 ? -0.61947  -29.25749 -30.91450 1.000 27.39335  ? 1311 ALA   B CB   1 
ATOM   4229 N  N    . MET   B 2 260 ? 0.57838   -31.94447 -29.54633 1.000 27.05655  ? 1312 MET   B N    1 
ATOM   4230 C  CA   . MET   B 2 260 ? 0.60234   -32.97739 -28.52425 1.000 30.55670  ? 1312 MET   B CA   1 
ATOM   4231 C  C    . MET   B 2 260 ? 0.20943   -32.40726 -27.16728 1.000 29.89314  ? 1312 MET   B C    1 
ATOM   4232 O  O    . MET   B 2 260 ? 0.79452   -31.42326 -26.71038 1.000 27.29327  ? 1312 MET   B O    1 
ATOM   4233 C  CB   . MET   B 2 260 ? 1.99430   -33.59749 -28.43125 1.000 29.56163  ? 1312 MET   B CB   1 
ATOM   4234 C  CG   . MET   B 2 260 ? 2.02325   -34.74341 -27.44616 1.000 32.31028  ? 1312 MET   B CG   1 
ATOM   4235 S  SD   . MET   B 2 260 ? 3.58420   -35.60551 -27.35015 1.000 35.58617  ? 1312 MET   B SD   1 
ATOM   4236 C  CE   . MET   B 2 260 ? 4.41730   -34.80647 -26.07724 1.000 44.47047  ? 1312 MET   B CE   1 
ATOM   4237 N  N    . LEU   B 2 261 ? -0.78459  -33.02813 -26.53520 1.000 28.92307  ? 1313 LEU   B N    1 
ATOM   4238 C  CA   . LEU   B 2 261 ? -1.14751  -32.66300 -25.17522 1.000 33.58857  ? 1313 LEU   B CA   1 
ATOM   4239 C  C    . LEU   B 2 261 ? 0.06251   -32.72301 -24.25025 1.000 35.33097  ? 1313 LEU   B C    1 
ATOM   4240 O  O    . LEU   B 2 261 ? 0.95345   -33.55809 -24.41322 1.000 37.11992  ? 1313 LEU   B O    1 
ATOM   4241 C  CB   . LEU   B 2 261 ? -2.24256  -33.58888 -24.64910 1.000 32.35738  ? 1313 LEU   B CB   1 
ATOM   4242 C  CG   . LEU   B 2 261 ? -3.55558  -33.39485 -25.42207 1.000 31.76535  ? 1313 LEU   B CG   1 
ATOM   4243 C  CD1  . LEU   B 2 261 ? -4.53064  -34.50175 -25.08995 1.000 33.54578  ? 1313 LEU   B CD1  1 
ATOM   4244 C  CD2  . LEU   B 2 261 ? -4.14846  -32.01178 -25.10416 1.000 28.78247  ? 1313 LEU   B CD2  1 
ATOM   4245 N  N    . GLN   B 2 262 ? 0.08561   -31.82194 -23.27033 1.000 35.24592  ? 1314 GLN   B N    1 
ATOM   4246 C  CA   . GLN   B 2 262 ? 1.22965   -31.73695 -22.32637 1.000 45.78250  ? 1314 GLN   B CA   1 
ATOM   4247 C  C    . GLN   B 2 262 ? 1.25960   -32.96788 -21.43528 1.000 48.58025  ? 1314 GLN   B C    1 
ATOM   4248 O  O    . GLN   B 2 262 ? 2.37956   -33.49595 -21.30827 1.000 61.14028  ? 1314 GLN   B O    1 
ATOM   4249 C  CB   . GLN   B 2 262 ? 1.15778   -30.50187 -21.43547 1.000 42.05871  ? 1314 GLN   B CB   1 
ATOM   4250 C  CG   . GLN   B 2 262 ? 1.89984   -29.29997 -22.00059 1.000 45.94963  ? 1314 GLN   B CG   1 
ATOM   4251 C  CD   . GLN   B 2 262 ? 3.19089   -28.99801 -21.27866 1.000 49.41134  ? 1314 GLN   B CD   1 
ATOM   4252 O  OE1  . GLN   B 2 262 ? 3.23494   -28.90791 -20.04867 1.000 54.50668  ? 1314 GLN   B OE1  1 
ATOM   4253 N  NE2  . GLN   B 2 262 ? 4.25987   -28.84014 -22.04271 1.000 54.37329  ? 1314 GLN   B NE2  1 
ATOM   4254 N  N    . ALA   B 2 263 ? 0.15060   -33.29975 -20.77121 1.000 46.31807  ? 1315 ALA   B N    1 
ATOM   4255 C  CA   . ALA   B 2 263 ? 0.03953   -34.54568 -20.00411 1.000 67.95359  ? 1315 ALA   B CA   1 
ATOM   4256 C  C    . ALA   B 2 263 ? 0.50459   -34.42360 -18.55413 1.000 69.91621  ? 1315 ALA   B C    1 
ATOM   4257 O  O    . ALA   B 2 263 ? 1.57165   -33.86765 -18.27222 1.000 65.99215  ? 1315 ALA   B O    1 
ATOM   4258 C  CB   . ALA   B 2 263 ? 0.81343   -35.68279 -20.67905 1.000 64.22531  ? 1315 ALA   B CB   1 
ATOM   4259 N  N    . ASP   B 2 264 ? -0.29441  -34.97947 -17.64606 1.000 77.99582  ? 1316 ASP   B N    1 
ATOM   4260 C  CA   . ASP   B 2 264 ? -0.08336  -34.95537 -16.19607 1.000 83.63966  ? 1316 ASP   B CA   1 
ATOM   4261 C  C    . ASP   B 2 264 ? 1.37566   -34.91344 -15.75013 1.000 82.65215  ? 1316 ASP   B C    1 
ATOM   4262 O  O    . ASP   B 2 264 ? 1.67469   -35.12637 -14.57212 1.000 87.44912  ? 1316 ASP   B O    1 
ATOM   4263 C  CB   . ASP   B 2 264 ? -0.76243  -36.18227 -15.57495 1.000 82.24844  ? 1316 ASP   B CB   1 
ATOM   4264 C  CG   . ASP   B 2 264 ? -2.07548  -36.53223 -16.27088 1.000 85.29978  ? 1316 ASP   B CG   1 
ATOM   4265 O  OD1  . ASP   B 2 264 ? -2.95442  -35.64817 -16.36691 1.000 88.82780  ? 1316 ASP   B OD1  1 
ATOM   4266 O  OD2  . ASP   B 2 264 ? -2.22058  -37.68426 -16.73778 1.000 90.01454  ? 1316 ASP   B OD2  1 
ATOM   4267 N  N    . LEU   B 2 269 ? -5.54611  -34.02356 -10.96395 1.000 66.70364  ? 1321 LEU   B N    1 
ATOM   4268 C  CA   . LEU   B 2 269 ? -6.31202  -33.46941 -9.81997  1.000 70.93967  ? 1321 LEU   B CA   1 
ATOM   4269 C  C    . LEU   B 2 269 ? -6.47292  -31.95942 -10.01308 1.000 71.87925  ? 1321 LEU   B C    1 
ATOM   4270 O  O    . LEU   B 2 269 ? -5.51886  -31.24346 -9.73217  1.000 69.09445  ? 1321 LEU   B O    1 
ATOM   4271 C  CB   . LEU   B 2 269 ? -5.58300  -33.77836 -8.51497  1.000 62.76636  ? 1321 LEU   B CB   1 
ATOM   4272 C  CG   . LEU   B 2 269 ? -6.13791  -33.09322 -7.26400  1.000 61.67160  ? 1321 LEU   B CG   1 
ATOM   4273 C  CD1  . LEU   B 2 269 ? -7.63192  -33.29911 -7.20493  1.000 56.86247  ? 1321 LEU   B CD1  1 
ATOM   4274 C  CD2  . LEU   B 2 269 ? -5.47290  -33.57917 -5.98899  1.000 52.28932  ? 1321 LEU   B CD2  1 
ATOM   4275 N  N    . MET   B 2 270 ? -7.66290  -31.49236 -10.37808 1.000 67.26992  ? 1322 MET   B N    1 
ATOM   4276 C  CA   . MET   B 2 270 ? -7.87981  -30.05237 -10.67718 1.000 66.81040  ? 1322 MET   B CA   1 
ATOM   4277 C  C    . MET   B 2 270 ? -7.33570  -29.10232 -9.58728  1.000 68.97948  ? 1322 MET   B C    1 
ATOM   4278 O  O    . MET   B 2 270 ? -7.46862  -27.90533 -9.78537  1.000 68.03667  ? 1322 MET   B O    1 
ATOM   4279 C  CB   . MET   B 2 270 ? -9.37480  -29.79727 -10.86115 1.000 69.98449  ? 1322 MET   B CB   1 
ATOM   4280 C  CG   . MET   B 2 270 ? -9.70673  -28.55031 -11.64223 1.000 71.00017  ? 1322 MET   B CG   1 
ATOM   4281 S  SD   . MET   B 2 270 ? -11.48374 -28.46820 -11.90718 1.000 85.78170  ? 1322 MET   B SD   1 
ATOM   4282 C  CE   . MET   B 2 270 ? -12.03370 -28.81003 -10.23213 1.000 56.15663  ? 1322 MET   B CE   1 
ATOM   4283 N  N    . GLU   B 2 271 ? -6.74270  -29.59128 -8.49726  1.000 69.46892  ? 1323 GLU   B N    1 
ATOM   4284 C  CA   . GLU   B 2 271 ? -6.12760  -28.70324 -7.47635  1.000 64.18514  ? 1323 GLU   B CA   1 
ATOM   4285 C  C    . GLU   B 2 271 ? -4.65159  -28.40837 -7.81643  1.000 71.20109  ? 1323 GLU   B C    1 
ATOM   4286 O  O    . GLU   B 2 271 ? -3.78858  -28.68337 -6.96244  1.000 72.11472  ? 1323 GLU   B O    1 
ATOM   4287 C  CB   . GLU   B 2 271 ? -6.44459  -29.34311 -6.13129  1.000 59.88049  ? 1323 GLU   B CB   1 
ATOM   4288 C  CG   . GLU   B 2 271 ? -7.87563  -29.86400 -6.03120  1.000 59.43860  ? 1323 GLU   B CG   1 
ATOM   4289 C  CD   . GLU   B 2 271 ? -8.97557  -28.88895 -6.39623  1.000 55.97248  ? 1323 GLU   B CD   1 
ATOM   4290 O  OE1  . GLU   B 2 271 ? -8.86147  -27.69693 -6.05933  1.000 59.72019  ? 1323 GLU   B OE1  1 
ATOM   4291 O  OE2  . GLU   B 2 271 ? -9.95463  -29.33393 -7.02416  1.000 58.97024  ? 1323 GLU   B OE2  1 
ATOM   4292 N  N    . GLU   B 2 272 ? -4.36759  -27.86349 -9.00048  1.000 73.44205  ? 1324 GLU   B N    1 
ATOM   4293 C  CA   . GLU   B 2 272 ? -3.05258  -27.44262 -9.45756  1.000 76.32161  ? 1324 GLU   B CA   1 
ATOM   4294 C  C    . GLU   B 2 272 ? -3.21251  -26.11166 -10.17966 1.000 69.44822  ? 1324 GLU   B C    1 
ATOM   4295 O  O    . GLU   B 2 272 ? -4.32449  -25.71361 -10.53665 1.000 71.77663  ? 1324 GLU   B O    1 
ATOM   4296 C  CB   . GLU   B 2 272 ? -2.43168  -28.48874 -10.39550 1.000 83.45683  ? 1324 GLU   B CB   1 
ATOM   4297 C  CG   . GLU   B 2 272 ? -2.08776  -29.81071 -9.69741  1.000 94.66967  ? 1324 GLU   B CG   1 
ATOM   4298 C  CD   . GLU   B 2 272 ? -1.53587  -30.87182 -10.65434 1.000 110.86355 ? 1324 GLU   B CD   1 
ATOM   4299 O  OE1  . GLU   B 2 272 ? -1.59489  -30.65692 -11.88036 1.000 107.15483 ? 1324 GLU   B OE1  1 
ATOM   4300 O  OE2  . GLU   B 2 272 ? -1.04593  -31.92682 -10.18028 1.000 110.81817 ? 1324 GLU   B OE2  1 
ATOM   4301 N  N    . ARG   B 2 273 ? -2.09646  -25.40876 -10.37976 1.000 66.30706  ? 1325 ARG   B N    1 
ATOM   4302 C  CA   . ARG   B 2 273 ? -2.13740  -24.15982 -11.13685 1.000 65.34980  ? 1325 ARG   B CA   1 
ATOM   4303 C  C    . ARG   B 2 273 ? -2.32847  -24.45792 -12.62682 1.000 66.28119  ? 1325 ARG   B C    1 
ATOM   4304 O  O    . ARG   B 2 273 ? -2.14657  -25.58897 -13.09374 1.000 63.71085  ? 1325 ARG   B O    1 
ATOM   4305 C  CB   . ARG   B 2 273 ? -0.85933  -23.34089 -10.91196 1.000 68.12728  ? 1325 ARG   B CB   1 
ATOM   4306 C  CG   . ARG   B 2 273 ? -1.07421  -21.85185 -10.55507 1.000 62.56953  ? 1325 ARG   B CG   1 
ATOM   4307 C  CD   . ARG   B 2 273 ? -1.37514  -21.65371 -9.05308  1.000 61.73140  ? 1325 ARG   B CD   1 
ATOM   4308 N  NE   . ARG   B 2 273 ? -1.13103  -20.28669 -8.58219  1.000 59.22296  ? 1325 ARG   B NE   1 
ATOM   4309 C  CZ   . ARG   B 2 273 ? -0.33597  -19.96067 -7.56425  1.000 52.77409  ? 1325 ARG   B CZ   1 
ATOM   4310 N  NH1  . ARG   B 2 273 ? 0.32899   -20.88566 -6.87920  1.000 38.55896  ? 1325 ARG   B NH1  1 
ATOM   4311 N  NH2  . ARG   B 2 273 ? -0.21386  -18.67465 -7.21536  1.000 48.29702  ? 1325 ARG   B NH2  1 
ATOM   4312 N  N    . MET   B 2 274 ? -2.69942  -23.42395 -13.38089 1.000 60.54121  ? 1326 MET   B N    1 
ATOM   4313 C  CA   . MET   B 2 274 ? -3.13049  -23.62103 -14.76186 1.000 65.73404  ? 1326 MET   B CA   1 
ATOM   4314 C  C    . MET   B 2 274 ? -1.92754  -23.87819 -15.66888 1.000 62.21124  ? 1326 MET   B C    1 
ATOM   4315 O  O    . MET   B 2 274 ? -1.02248  -23.04226 -15.75898 1.000 63.21385  ? 1326 MET   B O    1 
ATOM   4316 C  CB   . MET   B 2 274 ? -3.92942  -22.41401 -15.24993 1.000 63.04578  ? 1326 MET   B CB   1 
ATOM   4317 C  CG   . MET   B 2 274 ? -4.92348  -22.77503 -16.34986 1.000 61.90574  ? 1326 MET   B CG   1 
ATOM   4318 S  SD   . MET   B 2 274 ? -6.05341  -21.46599 -16.85293 1.000 66.27910  ? 1326 MET   B SD   1 
ATOM   4319 C  CE   . MET   B 2 274 ? -6.95333  -21.16680 -15.32292 1.000 52.19321  ? 1326 MET   B CE   1 
ATOM   4320 N  N    . LYS   B 2 275 ? -1.92565  -25.03324 -16.33979 1.000 55.83310  ? 1327 LYS   B N    1 
ATOM   4321 C  CA   . LYS   B 2 275 ? -0.90271  -25.42040 -17.30380 1.000 54.41536  ? 1327 LYS   B CA   1 
ATOM   4322 C  C    . LYS   B 2 275 ? -1.46375  -25.34147 -18.71678 1.000 44.36556  ? 1327 LYS   B C    1 
ATOM   4323 O  O    . LYS   B 2 275 ? -2.66877  -25.50440 -18.94273 1.000 46.61013  ? 1327 LYS   B O    1 
ATOM   4324 C  CB   . LYS   B 2 275 ? -0.40280  -26.85341 -17.06770 1.000 53.15680  ? 1327 LYS   B CB   1 
ATOM   4325 C  CG   . LYS   B 2 275 ? 0.36422   -27.07737 -15.79071 1.000 64.30306  ? 1327 LYS   B CG   1 
ATOM   4326 C  CD   . LYS   B 2 275 ? 0.77612   -28.54239 -15.67561 1.000 74.64174  ? 1327 LYS   B CD   1 
ATOM   4327 C  CE   . LYS   B 2 275 ? 1.58015   -28.79134 -14.39862 1.000 97.78806  ? 1327 LYS   B CE   1 
ATOM   4328 N  NZ   . LYS   B 2 275 ? 2.00306   -30.20636 -14.19552 1.000 88.92621  ? 1327 LYS   B NZ   1 
ATOM   4329 N  N    . SER   B 2 276 ? -0.57877  -25.11961 -19.67483 1.000 45.02778  ? 1328 SER   B N    1 
ATOM   4330 C  CA   . SER   B 2 276 ? -1.01982  -25.09068 -21.05782 1.000 42.51424  ? 1328 SER   B CA   1 
ATOM   4331 C  C    . SER   B 2 276 ? -1.44994  -26.49269 -21.48269 1.000 40.50557  ? 1328 SER   B C    1 
ATOM   4332 O  O    . SER   B 2 276 ? -0.83399  -27.48670 -21.08264 1.000 37.90501  ? 1328 SER   B O    1 
ATOM   4333 C  CB   . SER   B 2 276 ? 0.09119   -24.57784 -21.96290 1.000 40.81634  ? 1328 SER   B CB   1 
ATOM   4334 O  OG   . SER   B 2 276 ? 1.26714   -25.30190 -21.70288 1.000 45.03744  ? 1328 SER   B OG   1 
ATOM   4335 N  N    . PRO   B 2 277 ? -2.50997  -26.61367 -22.27465 1.000 36.29355  ? 1329 PRO   B N    1 
ATOM   4336 C  CA   . PRO   B 2 277 ? -2.92208  -27.95268 -22.70352 1.000 32.04465  ? 1329 PRO   B CA   1 
ATOM   4337 C  C    . PRO   B 2 277 ? -1.91117  -28.62882 -23.61151 1.000 32.49975  ? 1329 PRO   B C    1 
ATOM   4338 O  O    . PRO   B 2 277 ? -1.83926  -29.86183 -23.60741 1.000 33.21147  ? 1329 PRO   B O    1 
ATOM   4339 C  CB   . PRO   B 2 277 ? -4.25209  -27.69464 -23.41850 1.000 35.48800  ? 1329 PRO   B CB   1 
ATOM   4340 C  CG   . PRO   B 2 277 ? -4.21700  -26.23167 -23.76661 1.000 30.63728  ? 1329 PRO   B CG   1 
ATOM   4341 C  CD   . PRO   B 2 277 ? -3.47391  -25.57863 -22.66769 1.000 35.82225  ? 1329 PRO   B CD   1 
ATOM   4342 N  N    . PHE   B 2 278 ? -1.11914  -27.87594 -24.37259 1.000 31.82527  ? 1330 PHE   B N    1 
ATOM   4343 C  CA   . PHE   B 2 278 ? -0.24422  -28.44708 -25.38058 1.000 27.25578  ? 1330 PHE   B CA   1 
ATOM   4344 C  C    . PHE   B 2 278 ? 1.21482   -28.10516 -25.09066 1.000 34.68355  ? 1330 PHE   B C    1 
ATOM   4345 O  O    . PHE   B 2 278 ? 1.54091   -27.26812 -24.24474 1.000 34.84587  ? 1330 PHE   B O    1 
ATOM   4346 C  CB   . PHE   B 2 278 ? -0.65823  -27.96516 -26.78660 1.000 27.76469  ? 1330 PHE   B CB   1 
ATOM   4347 C  CG   . PHE   B 2 278 ? -2.04728  -28.38609 -27.17452 1.000 30.13583  ? 1330 PHE   B CG   1 
ATOM   4348 C  CD1  . PHE   B 2 278 ? -2.29939  -29.69011 -27.60741 1.000 30.82534  ? 1330 PHE   B CD1  1 
ATOM   4349 C  CD2  . PHE   B 2 278 ? -3.11121  -27.49601 -27.09155 1.000 27.20192  ? 1330 PHE   B CD2  1 
ATOM   4350 C  CE1  . PHE   B 2 278 ? -3.59743  -30.09504 -27.95333 1.000 30.00362  ? 1330 PHE   B CE1  1 
ATOM   4351 C  CE2  . PHE   B 2 278 ? -4.40725  -27.88594 -27.42348 1.000 26.03014  ? 1330 PHE   B CE2  1 
ATOM   4352 C  CZ   . PHE   B 2 278 ? -4.65836  -29.18096 -27.85737 1.000 27.89365  ? 1330 PHE   B CZ   1 
ATOM   4353 N  N    . GLY   B 2 279 ? 2.09474   -28.79328 -25.80764 1.000 33.33996  ? 1331 GLY   B N    1 
ATOM   4354 C  CA   . GLY   B 2 279 ? 3.50877   -28.49139 -25.80271 1.000 37.51959  ? 1331 GLY   B CA   1 
ATOM   4355 C  C    . GLY   B 2 279 ? 3.81082   -27.26948 -26.64282 1.000 38.90886  ? 1331 GLY   B C    1 
ATOM   4356 O  O    . GLY   B 2 279 ? 2.94587   -26.43243 -26.91485 1.000 32.54717  ? 1331 GLY   B O    1 
ATOM   4357 N  N    . SER   B 2 280 ? 5.06481   -27.17860 -27.07787 1.000 39.85923  ? 1332 SER   B N    1 
ATOM   4358 C  CA   . SER   B 2 280 ? 5.57088   -25.98069 -27.72698 1.000 39.07978  ? 1332 SER   B CA   1 
ATOM   4359 C  C    . SER   B 2 280 ? 5.64481   -26.10981 -29.24698 1.000 40.11916  ? 1332 SER   B C    1 
ATOM   4360 O  O    . SER   B 2 280 ? 6.14286   -25.19690 -29.91507 1.000 47.11267  ? 1332 SER   B O    1 
ATOM   4361 C  CB   . SER   B 2 280 ? 6.94892   -25.62474 -27.16506 1.000 41.95046  ? 1332 SER   B CB   1 
ATOM   4362 O  OG   . SER   B 2 280 ? 7.88384   -26.65583 -27.44001 1.000 50.17006  ? 1332 SER   B OG   1 
ATOM   4363 N  N    . SER   B 2 281 ? 5.16471   -27.21082 -29.81587 1.000 36.83956  ? 1333 SER   B N    1 
ATOM   4364 C  CA   . SER   B 2 281 ? 5.22665   -27.38094 -31.25886 1.000 41.14812  ? 1333 SER   B CA   1 
ATOM   4365 C  C    . SER   B 2 281 ? 3.90659   -27.93289 -31.78277 1.000 39.39602  ? 1333 SER   B C    1 
ATOM   4366 O  O    . SER   B 2 281 ? 3.16557   -28.61078 -31.06369 1.000 37.14952  ? 1333 SER   B O    1 
ATOM   4367 C  CB   . SER   B 2 281 ? 6.38557   -28.30906 -31.64883 1.000 40.69156  ? 1333 SER   B CB   1 
ATOM   4368 O  OG   . SER   B 2 281 ? 6.29751   -29.53599 -30.93773 1.000 45.20218  ? 1333 SER   B OG   1 
ATOM   4369 N  N    . PHE   B 2 282 ? 3.61557   -27.62797 -33.03978 1.000 32.22415  ? 1334 PHE   B N    1 
ATOM   4370 C  CA   . PHE   B 2 282 ? 2.56749   -28.32595 -33.76369 1.000 34.11585  ? 1334 PHE   B CA   1 
ATOM   4371 C  C    . PHE   B 2 282 ? 3.16041   -28.84409 -35.06467 1.000 39.61695  ? 1334 PHE   B C    1 
ATOM   4372 O  O    . PHE   B 2 282 ? 4.26342   -28.46021 -35.45774 1.000 36.65502  ? 1334 PHE   B O    1 
ATOM   4373 C  CB   . PHE   B 2 282 ? 1.34255   -27.43388 -34.02472 1.000 30.69434  ? 1334 PHE   B CB   1 
ATOM   4374 C  CG   . PHE   B 2 282 ? 1.60760   -26.22897 -34.90382 1.000 35.93399  ? 1334 PHE   B CG   1 
ATOM   4375 C  CD1  . PHE   B 2 282 ? 2.01671   -25.01696 -34.35693 1.000 32.24882  ? 1334 PHE   B CD1  1 
ATOM   4376 C  CD2  . PHE   B 2 282 ? 1.39555   -26.29406 -36.28381 1.000 37.26543  ? 1334 PHE   B CD2  1 
ATOM   4377 C  CE1  . PHE   B 2 282 ? 2.23576   -23.89404 -35.17003 1.000 30.56276  ? 1334 PHE   B CE1  1 
ATOM   4378 C  CE2  . PHE   B 2 282 ? 1.62060   -25.16714 -37.09891 1.000 38.20544  ? 1334 PHE   B CE2  1 
ATOM   4379 C  CZ   . PHE   B 2 282 ? 2.04771   -23.97013 -36.53302 1.000 35.12556  ? 1334 PHE   B CZ   1 
ATOM   4380 N  N    . ARG   B 2 283 ? 2.42632   -29.72309 -35.73758 1.000 33.74011  ? 1335 ARG   B N    1 
ATOM   4381 C  CA   . ARG   B 2 283 ? 2.88424   -30.26923 -36.99855 1.000 33.94721  ? 1335 ARG   B CA   1 
ATOM   4382 C  C    . ARG   B 2 283 ? 1.73520   -30.30522 -37.98550 1.000 34.52958  ? 1335 ARG   B C    1 
ATOM   4383 O  O    . ARG   B 2 283 ? 0.57220   -30.46011 -37.60945 1.000 34.58897  ? 1335 ARG   B O    1 
ATOM   4384 C  CB   . ARG   B 2 283 ? 3.46514   -31.67725 -36.81346 1.000 39.58450  ? 1335 ARG   B CB   1 
ATOM   4385 C  CG   . ARG   B 2 283 ? 4.59518   -31.69226 -35.81450 1.000 44.47100  ? 1335 ARG   B CG   1 
ATOM   4386 C  CD   . ARG   B 2 283 ? 4.91209   -33.08224 -35.30940 1.000 46.48630  ? 1335 ARG   B CD   1 
ATOM   4387 N  NE   . ARG   B 2 283 ? 5.44600   -33.92436 -36.36935 1.000 56.17276  ? 1335 ARG   B NE   1 
ATOM   4388 C  CZ   . ARG   B 2 283 ? 6.40394   -34.81942 -36.18731 1.000 58.18143  ? 1335 ARG   B CZ   1 
ATOM   4389 N  NH1  . ARG   B 2 283 ? 6.96297   -34.99436 -34.99432 1.000 56.16709  ? 1335 ARG   B NH1  1 
ATOM   4390 N  NH2  . ARG   B 2 283 ? 6.81685   -35.54853 -37.22327 1.000 52.27086  ? 1335 ARG   B NH2  1 
ATOM   4391 N  N    . THR   B 2 284 ? 2.08016   -30.17935 -39.25953 1.000 34.96685  ? 1336 THR   B N    1 
ATOM   4392 C  CA   . THR   B 2 284 ? 1.12811   -30.33436 -40.34048 1.000 34.02256  ? 1336 THR   B CA   1 
ATOM   4393 C  C    . THR   B 2 284 ? 1.41699   -31.64044 -41.06939 1.000 33.39174  ? 1336 THR   B C    1 
ATOM   4394 O  O    . THR   B 2 284 ? 2.56396   -32.09053 -41.15339 1.000 32.22684  ? 1336 THR   B O    1 
ATOM   4395 C  CB   . THR   B 2 284 ? 1.18716   -29.14545 -41.30858 1.000 37.96623  ? 1336 THR   B CB   1 
ATOM   4396 O  OG1  . THR   B 2 284 ? 2.53516   -28.95658 -41.75864 1.000 37.79409  ? 1336 THR   B OG1  1 
ATOM   4397 C  CG2  . THR   B 2 284 ? 0.72728   -27.87736 -40.60766 1.000 34.64139  ? 1336 THR   B CG2  1 
ATOM   4398 N  N    . PHE   B 2 285 ? 0.35993   -32.25741 -41.56330 1.000 30.02396  ? 1337 PHE   B N    1 
ATOM   4399 C  CA   . PHE   B 2 285 ? 0.45181   -33.51247 -42.28120 1.000 33.75376  ? 1337 PHE   B CA   1 
ATOM   4400 C  C    . PHE   B 2 285 ? -0.37622  -33.42051 -43.54618 1.000 37.16087  ? 1337 PHE   B C    1 
ATOM   4401 O  O    . PHE   B 2 285 ? -1.40318  -32.73444 -43.59820 1.000 36.87827  ? 1337 PHE   B O    1 
ATOM   4402 C  CB   . PHE   B 2 285 ? -0.04724  -34.69437 -41.44209 1.000 35.39747  ? 1337 PHE   B CB   1 
ATOM   4403 C  CG   . PHE   B 2 285 ? 0.60380   -34.79631 -40.09711 1.000 33.91678  ? 1337 PHE   B CG   1 
ATOM   4404 C  CD1  . PHE   B 2 285 ? 0.13789   -34.04919 -39.03215 1.000 35.93834  ? 1337 PHE   B CD1  1 
ATOM   4405 C  CD2  . PHE   B 2 285 ? 1.67374   -35.65737 -39.89208 1.000 35.77185  ? 1337 PHE   B CD2  1 
ATOM   4406 C  CE1  . PHE   B 2 285 ? 0.73993   -34.14113 -37.78617 1.000 28.93470  ? 1337 PHE   B CE1  1 
ATOM   4407 C  CE2  . PHE   B 2 285 ? 2.27878   -35.75631 -38.65109 1.000 34.69808  ? 1337 PHE   B CE2  1 
ATOM   4408 C  CZ   . PHE   B 2 285 ? 1.81587   -34.99820 -37.60414 1.000 36.56601  ? 1337 PHE   B CZ   1 
ATOM   4409 N  N    . ASN   B 2 286 ? 0.09169   -34.11762 -44.56814 1.000 37.77502  ? 1338 ASN   B N    1 
ATOM   4410 C  CA   . ASN   B 2 286 ? -0.71137  -34.33166 -45.75510 1.000 36.43748  ? 1338 ASN   B CA   1 
ATOM   4411 C  C    . ASN   B 2 286 ? -1.93341  -35.15354 -45.36499 1.000 37.55040  ? 1338 ASN   B C    1 
ATOM   4412 O  O    . ASN   B 2 286 ? -1.80547  -36.25051 -44.81191 1.000 37.28059  ? 1338 ASN   B O    1 
ATOM   4413 C  CB   . ASN   B 2 286 ? 0.14054   -35.04181 -46.81007 1.000 37.87398  ? 1338 ASN   B CB   1 
ATOM   4414 C  CG   . ASN   B 2 286 ? -0.57152  -35.22786 -48.10703 1.000 41.79745  ? 1338 ASN   B CG   1 
ATOM   4415 O  OD1  . ASN   B 2 286 ? -1.71955  -35.66578 -48.13996 1.000 40.89267  ? 1338 ASN   B OD1  1 
ATOM   4416 N  ND2  . ASN   B 2 286 ? 0.11147   -34.90799 -49.20308 1.000 43.88952  ? 1338 ASN   B ND2  1 
ATOM   4417 N  N    . ALA   B 2 287 ? -3.12138  -34.61248 -45.61799 1.000 33.97190  ? 1339 ALA   B N    1 
ATOM   4418 C  CA   . ALA   B 2 287 ? -4.33441  -35.25235 -45.11290 1.000 37.56598  ? 1339 ALA   B CA   1 
ATOM   4419 C  C    . ALA   B 2 287 ? -4.66653  -36.54938 -45.83578 1.000 38.46716  ? 1339 ALA   B C    1 
ATOM   4420 O  O    . ALA   B 2 287 ? -5.49157  -37.31728 -45.33669 1.000 40.18880  ? 1339 ALA   B O    1 
ATOM   4421 C  CB   . ALA   B 2 287 ? -5.53035  -34.29827 -45.21193 1.000 35.92471  ? 1339 ALA   B CB   1 
ATOM   4422 N  N    . THR   B 2 288 ? -4.06659  -36.80552 -46.99778 1.000 35.83825  ? 1340 THR   B N    1 
ATOM   4423 C  CA   . THR   B 2 288 ? -4.38671  -38.01055 -47.76068 1.000 37.63445  ? 1340 THR   B CA   1 
ATOM   4424 C  C    . THR   B 2 288 ? -3.55378  -39.21958 -47.33661 1.000 39.76331  ? 1340 THR   B C    1 
ATOM   4425 O  O    . THR   B 2 288 ? -4.07786  -40.33954 -47.25650 1.000 39.22963  ? 1340 THR   B O    1 
ATOM   4426 C  CB   . THR   B 2 288 ? -4.20374  -37.74069 -49.26070 1.000 39.39249  ? 1340 THR   B CB   1 
ATOM   4427 O  OG1  . THR   B 2 288 ? -2.87371  -37.27080 -49.49279 1.000 50.20954  ? 1340 THR   B OG1  1 
ATOM   4428 C  CG2  . THR   B 2 288 ? -5.15968  -36.67265 -49.71975 1.000 33.88866  ? 1340 THR   B CG2  1 
ATOM   4429 N  N    . ASP   B 2 289 ? -2.27475  -39.01665 -47.03367 1.000 34.25759  ? 1341 ASP   B N    1 
ATOM   4430 C  CA   . ASP   B 2 289 ? -1.38182  -40.11569 -46.69862 1.000 38.77680  ? 1341 ASP   B CA   1 
ATOM   4431 C  C    . ASP   B 2 289 ? -0.70676  -39.94163 -45.34665 1.000 41.63822  ? 1341 ASP   B C    1 
ATOM   4432 O  O    . ASP   B 2 289 ? 0.12619   -40.77766 -44.97662 1.000 38.35740  ? 1341 ASP   B O    1 
ATOM   4433 C  CB   . ASP   B 2 289 ? -0.31087  -40.27485 -47.79264 1.000 42.18348  ? 1341 ASP   B CB   1 
ATOM   4434 C  CG   . ASP   B 2 289 ? 0.52621   -39.01093 -47.97877 1.000 47.00874  ? 1341 ASP   B CG   1 
ATOM   4435 O  OD1  . ASP   B 2 289 ? 0.29831   -38.02685 -47.23284 1.000 45.78780  ? 1341 ASP   B OD1  1 
ATOM   4436 O  OD2  . ASP   B 2 289 ? 1.40518   -39.00306 -48.86980 1.000 49.98234  ? 1341 ASP   B OD2  1 
ATOM   4437 N  N    . TYR   B 2 290 ? -1.03566  -38.88055 -44.60773 1.000 39.11700  ? 1342 TYR   B N    1 
ATOM   4438 C  CA   . TYR   B 2 290 ? -0.48159  -38.60248 -43.28277 1.000 35.51253  ? 1342 TYR   B CA   1 
ATOM   4439 C  C    . TYR   B 2 290 ? 1.02243   -38.35759 -43.31684 1.000 33.52431  ? 1342 TYR   B C    1 
ATOM   4440 O  O    . TYR   B 2 290 ? 1.69146   -38.39556 -42.28086 1.000 35.22149  ? 1342 TYR   B O    1 
ATOM   4441 C  CB   . TYR   B 2 290 ? -0.84263  -39.71238 -42.28767 1.000 33.49262  ? 1342 TYR   B CB   1 
ATOM   4442 C  CG   . TYR   B 2 290 ? -2.33764  -39.83326 -42.14561 1.000 34.36003  ? 1342 TYR   B CG   1 
ATOM   4443 C  CD1  . TYR   B 2 290 ? -3.02855  -39.04514 -41.24264 1.000 29.72694  ? 1342 TYR   B CD1  1 
ATOM   4444 C  CD2  . TYR   B 2 290 ? -3.06973  -40.68827 -42.96651 1.000 33.69639  ? 1342 TYR   B CD2  1 
ATOM   4445 C  CE1  . TYR   B 2 290 ? -4.41155  -39.13003 -41.12559 1.000 30.63544  ? 1342 TYR   B CE1  1 
ATOM   4446 C  CE2  . TYR   B 2 290 ? -4.45273  -40.79016 -42.85245 1.000 34.54783  ? 1342 TYR   B CE2  1 
ATOM   4447 C  CZ   . TYR   B 2 290 ? -5.12064  -40.00304 -41.93049 1.000 32.31124  ? 1342 TYR   B CZ   1 
ATOM   4448 O  OH   . TYR   B 2 290 ? -6.50364  -40.08493 -41.81344 1.000 31.45284  ? 1342 TYR   B OH   1 
ATOM   4449 N  N    . LYS   B 2 291 ? 1.55841   -38.05372 -44.46989 1.000 39.99688  ? 1343 LYS   B N    1 
ATOM   4450 C  CA   . LYS   B 2 291 ? 2.98243   -37.74983 -44.51496 1.000 44.10051  ? 1343 LYS   B CA   1 
ATOM   4451 C  C    . LYS   B 2 291 ? 3.25055   -36.35680 -43.94408 1.000 40.84004  ? 1343 LYS   B C    1 
ATOM   4452 O  O    . LYS   B 2 291 ? 2.50861   -35.41077 -44.23713 1.000 38.19717  ? 1343 LYS   B O    1 
ATOM   4453 C  CB   . LYS   B 2 291 ? 3.49537   -37.84398 -45.94697 1.000 46.41580  ? 1343 LYS   B CB   1 
ATOM   4454 C  CG   . LYS   B 2 291 ? 4.47628   -38.98307 -46.13492 1.000 53.19187  ? 1343 LYS   B CG   1 
ATOM   4455 C  CD   . LYS   B 2 291 ? 4.30918   -39.67016 -47.48386 1.000 58.16230  ? 1343 LYS   B CD   1 
ATOM   4456 C  CE   . LYS   B 2 291 ? 5.14309   -40.94622 -47.52078 1.000 62.23353  ? 1343 LYS   B CE   1 
ATOM   4457 N  NZ   . LYS   B 2 291 ? 4.72198   -41.85828 -48.61770 1.000 72.78198  ? 1343 LYS   B NZ   1 
ATOM   4458 N  N    . PRO   B 2 292 ? 4.31159   -36.20082 -43.15513 1.000 39.84998  ? 1344 PRO   B N    1 
ATOM   4459 C  CA   . PRO   B 2 292 ? 4.56771   -34.90179 -42.51724 1.000 41.00121  ? 1344 PRO   B CA   1 
ATOM   4460 C  C    . PRO   B 2 292 ? 4.85675   -33.83089 -43.55434 1.000 40.23927  ? 1344 PRO   B C    1 
ATOM   4461 O  O    . PRO   B 2 292 ? 5.53069   -34.08302 -44.55834 1.000 42.16213  ? 1344 PRO   B O    1 
ATOM   4462 C  CB   . PRO   B 2 292 ? 5.79272   -35.16480 -41.63326 1.000 38.66739  ? 1344 PRO   B CB   1 
ATOM   4463 C  CG   . PRO   B 2 292 ? 5.96761   -36.65282 -41.61315 1.000 43.67597  ? 1344 PRO   B CG   1 
ATOM   4464 C  CD   . PRO   B 2 292 ? 5.37053   -37.17687 -42.87909 1.000 39.22923  ? 1344 PRO   B CD   1 
ATOM   4465 N  N    . ILE   B 2 293 ? 4.32784   -32.63583 -43.31841 1.000 37.39571  ? 1345 ILE   B N    1 
ATOM   4466 C  CA   . ILE   B 2 293 ? 4.64690   -31.46692 -44.13052 1.000 35.90755  ? 1345 ILE   B CA   1 
ATOM   4467 C  C    . ILE   B 2 293 ? 5.63699   -30.56493 -43.41362 1.000 46.28988  ? 1345 ILE   B C    1 
ATOM   4468 O  O    . ILE   B 2 293 ? 6.69299   -30.23805 -43.95169 1.000 43.36472  ? 1345 ILE   B O    1 
ATOM   4469 C  CB   . ILE   B 2 293 ? 3.35894   -30.69485 -44.48753 1.000 36.31082  ? 1345 ILE   B CB   1 
ATOM   4470 C  CG1  . ILE   B 2 293 ? 2.48985   -31.52886 -45.41543 1.000 36.96713  ? 1345 ILE   B CG1  1 
ATOM   4471 C  CG2  . ILE   B 2 293 ? 3.69301   -29.35693 -45.11865 1.000 34.06428  ? 1345 ILE   B CG2  1 
ATOM   4472 C  CD1  . ILE   B 2 293 ? 1.10688   -30.95078 -45.60243 1.000 38.62439  ? 1345 ILE   B CD1  1 
ATOM   4473 N  N    . ALA   B 2 294 ? 5.32006   -30.16381 -42.18164 1.000 40.19138  ? 1346 ALA   B N    1 
ATOM   4474 C  CA   . ALA   B 2 294 ? 6.17615   -29.23682 -41.45975 1.000 37.46524  ? 1346 ALA   B CA   1 
ATOM   4475 C  C    . ALA   B 2 294 ? 6.04619   -29.49069 -39.96572 1.000 38.01154  ? 1346 ALA   B C    1 
ATOM   4476 O  O    . ALA   B 2 294 ? 5.01517   -29.96558 -39.48765 1.000 40.64280  ? 1346 ALA   B O    1 
ATOM   4477 C  CB   . ALA   B 2 294 ? 5.82225   -27.78182 -41.77885 1.000 39.63297  ? 1346 ALA   B CB   1 
ATOM   4478 N  N    . THR   B 2 295 ? 7.11223   -29.19971 -39.23778 1.000 37.04645  ? 1347 THR   B N    1 
ATOM   4479 C  CA   . THR   B 2 295 ? 7.07429   -29.16459 -37.78479 1.000 39.56981  ? 1347 THR   B CA   1 
ATOM   4480 C  C    . THR   B 2 295 ? 7.43841   -27.75758 -37.35091 1.000 39.87728  ? 1347 THR   B C    1 
ATOM   4481 O  O    . THR   B 2 295 ? 8.46843   -27.22269 -37.77199 1.000 38.92923  ? 1347 THR   B O    1 
ATOM   4482 C  CB   . THR   B 2 295 ? 8.01724   -30.19061 -37.16074 1.000 42.65667  ? 1347 THR   B CB   1 
ATOM   4483 O  OG1  . THR   B 2 295 ? 7.67713   -31.48963 -37.65062 1.000 46.26638  ? 1347 THR   B OG1  1 
ATOM   4484 C  CG2  . THR   B 2 295 ? 7.85829   -30.19548 -35.63973 1.000 46.01823  ? 1347 THR   B CG2  1 
ATOM   4485 N  N    . ILE   B 2 296 ? 6.57048   -27.14646 -36.55193 1.000 42.55666  ? 1348 ILE   B N    1 
ATOM   4486 C  CA   . ILE   B 2 296 ? 6.69959   -25.74944 -36.16104 1.000 39.14946  ? 1348 ILE   B CA   1 
ATOM   4487 C  C    . ILE   B 2 296 ? 6.88865   -25.71433 -34.65905 1.000 40.37835  ? 1348 ILE   B C    1 
ATOM   4488 O  O    . ILE   B 2 296 ? 5.96665   -26.04021 -33.90199 1.000 46.94109  ? 1348 ILE   B O    1 
ATOM   4489 C  CB   . ILE   B 2 296 ? 5.48464   -24.91738 -36.58206 1.000 39.17927  ? 1348 ILE   B CB   1 
ATOM   4490 C  CG1  . ILE   B 2 296 ? 5.19857   -25.11048 -38.07404 1.000 40.32019  ? 1348 ILE   B CG1  1 
ATOM   4491 C  CG2  . ILE   B 2 296 ? 5.70876   -23.45737 -36.24819 1.000 37.54875  ? 1348 ILE   B CG2  1 
ATOM   4492 C  CD1  . ILE   B 2 296 ? 6.35057   -24.73364 -38.98211 1.000 49.34298  ? 1348 ILE   B CD1  1 
ATOM   4493 N  N    . ASP   B 2 297 ? 8.08169   -25.34038 -34.22612 1.000 36.64259  ? 1349 ASP   B N    1 
ATOM   4494 C  CA   . ASP   B 2 297 ? 8.37976   -25.16329 -32.81315 1.000 44.50232  ? 1349 ASP   B CA   1 
ATOM   4495 C  C    . ASP   B 2 297 ? 8.35887   -23.66927 -32.51127 1.000 47.94228  ? 1349 ASP   B C    1 
ATOM   4496 O  O    . ASP   B 2 297 ? 9.27791   -22.93937 -32.89836 1.000 50.33020  ? 1349 ASP   B O    1 
ATOM   4497 C  CB   . ASP   B 2 297 ? 9.72872   -25.78836 -32.47215 1.000 49.89158  ? 1349 ASP   B CB   1 
ATOM   4498 C  CG   . ASP   B 2 297 ? 10.13979  -25.55828 -31.02918 1.000 56.53909  ? 1349 ASP   B CG   1 
ATOM   4499 O  OD1  . ASP   B 2 297 ? 9.30085   -25.09915 -30.21619 1.000 53.35981  ? 1349 ASP   B OD1  1 
ATOM   4500 O  OD2  . ASP   B 2 297 ? 11.31978  -25.83834 -30.71320 1.000 69.66216  ? 1349 ASP   B OD2  1 
ATOM   4501 N  N    . VAL   B 2 298 ? 7.29693   -23.21014 -31.83926 1.000 43.45958  ? 1350 VAL   B N    1 
ATOM   4502 C  CA   . VAL   B 2 298 ? 7.17505   -21.79310 -31.49437 1.000 46.63173  ? 1350 VAL   B CA   1 
ATOM   4503 C  C    . VAL   B 2 298 ? 7.90712   -21.43305 -30.21743 1.000 47.90022  ? 1350 VAL   B C    1 
ATOM   4504 O  O    . VAL   B 2 298 ? 7.84822   -20.26902 -29.79252 1.000 49.90304  ? 1350 VAL   B O    1 
ATOM   4505 C  CB   . VAL   B 2 298 ? 5.71009   -21.34298 -31.31436 1.000 47.76276  ? 1350 VAL   B CB   1 
ATOM   4506 C  CG1  . VAL   B 2 298 ? 4.97203   -21.45503 -32.61332 1.000 39.37492  ? 1350 VAL   B CG1  1 
ATOM   4507 C  CG2  . VAL   B 2 298 ? 5.03407   -22.15085 -30.20227 1.000 41.38176  ? 1350 VAL   B CG2  1 
ATOM   4508 N  N    . LYS   B 2 299 ? 8.57407   -22.39805 -29.58237 1.000 46.11175  ? 1351 LYS   B N    1 
ATOM   4509 C  CA   . LYS   B 2 299 ? 9.41613   -22.15902 -28.41342 1.000 49.15248  ? 1351 LYS   B CA   1 
ATOM   4510 C  C    . LYS   B 2 299 ? 8.62221   -21.64187 -27.22444 1.000 50.46972  ? 1351 LYS   B C    1 
ATOM   4511 O  O    . LYS   B 2 299 ? 9.18729   -21.04084 -26.30150 1.000 49.24411  ? 1351 LYS   B O    1 
ATOM   4512 C  CB   . LYS   B 2 299 ? 10.55619  -21.19413 -28.75054 1.000 49.93830  ? 1351 LYS   B CB   1 
ATOM   4513 C  CG   . LYS   B 2 299 ? 11.39711  -21.61629 -29.95754 1.000 55.46876  ? 1351 LYS   B CG   1 
ATOM   4514 C  CD   . LYS   B 2 299 ? 11.81201  -23.09831 -29.89943 1.000 61.11382  ? 1351 LYS   B CD   1 
ATOM   4515 C  CE   . LYS   B 2 299 ? 13.03502  -23.35833 -29.02146 1.000 64.57026  ? 1351 LYS   B CE   1 
ATOM   4516 N  NZ   . LYS   B 2 299 ? 13.61291  -24.70640 -29.31137 1.000 63.63148  ? 1351 LYS   B NZ   1 
ATOM   4517 N  N    . ARG   B 2 300 ? 7.31019   -21.85778 -27.24237 1.000 48.89273  ? 1352 ARG   B N    1 
ATOM   4518 C  CA   . ARG   B 2 300 ? 6.41926   -21.48662 -26.15337 1.000 42.79375  ? 1352 ARG   B CA   1 
ATOM   4519 C  C    . ARG   B 2 300 ? 5.27619   -22.48954 -26.13125 1.000 39.11829  ? 1352 ARG   B C    1 
ATOM   4520 O  O    . ARG   B 2 300 ? 4.88411   -23.02559 -27.17219 1.000 36.06866  ? 1352 ARG   B O    1 
ATOM   4521 C  CB   . ARG   B 2 300 ? 5.88436   -20.05460 -26.32746 1.000 38.75316  ? 1352 ARG   B CB   1 
ATOM   4522 C  CG   . ARG   B 2 300 ? 6.94841   -19.08271 -26.79858 1.000 45.35150  ? 1352 ARG   B CG   1 
ATOM   4523 C  CD   . ARG   B 2 300 ? 6.61753   -17.63867 -26.49468 1.000 46.37400  ? 1352 ARG   B CD   1 
ATOM   4524 N  NE   . ARG   B 2 300 ? 5.83454   -16.98569 -27.53470 1.000 47.58512  ? 1352 ARG   B NE   1 
ATOM   4525 C  CZ   . ARG   B 2 300 ? 6.28651   -16.68882 -28.74974 1.000 60.07792  ? 1352 ARG   B CZ   1 
ATOM   4526 N  NH1  . ARG   B 2 300 ? 7.49247   -17.06994 -29.16476 1.000 62.80372  ? 1352 ARG   B NH1  1 
ATOM   4527 N  NH2  . ARG   B 2 300 ? 5.51354   -15.98783 -29.56577 1.000 52.65371  ? 1352 ARG   B NH2  1 
ATOM   4528 N  N    . ASN   B 2 301 ? 4.75521   -22.74641 -24.94121 1.000 32.73830  ? 1353 ASN   B N    1 
ATOM   4529 C  CA   . ASN   B 2 301 ? 3.64415   -23.66932 -24.82810 1.000 34.94374  ? 1353 ASN   B CA   1 
ATOM   4530 C  C    . ASN   B 2 301 ? 2.41816   -23.10929 -25.53410 1.000 29.83419  ? 1353 ASN   B C    1 
ATOM   4531 O  O    . ASN   B 2 301 ? 2.16025   -21.90327 -25.50318 1.000 31.14951  ? 1353 ASN   B O    1 
ATOM   4532 C  CB   . ASN   B 2 301 ? 3.35118   -23.96018 -23.36606 1.000 35.63026  ? 1353 ASN   B CB   1 
ATOM   4533 C  CG   . ASN   B 2 301 ? 4.37614   -24.88121 -22.76503 1.000 44.12148  ? 1353 ASN   B CG   1 
ATOM   4534 O  OD1  . ASN   B 2 301 ? 4.88305   -25.78030 -23.43697 1.000 47.38903  ? 1353 ASN   B OD1  1 
ATOM   4535 N  ND2  . ASN   B 2 301 ? 4.70520   -24.66113 -21.50706 1.000 51.77492  ? 1353 ASN   B ND2  1 
ATOM   4536 N  N    . ILE   B 2 302 ? 1.66008   -24.00428 -26.16300 1.000 27.58244  ? 1354 ILE   B N    1 
ATOM   4537 C  CA   . ILE   B 2 302 ? 0.52707   -23.64727 -27.00199 1.000 27.18956  ? 1354 ILE   B CA   1 
ATOM   4538 C  C    . ILE   B 2 302 ? -0.76592  -23.96111 -26.26492 1.000 29.02439  ? 1354 ILE   B C    1 
ATOM   4539 O  O    . ILE   B 2 302 ? -0.90898  -25.03606 -25.67483 1.000 28.74751  ? 1354 ILE   B O    1 
ATOM   4540 C  CB   . ILE   B 2 302 ? 0.58797   -24.38438 -28.34793 1.000 28.28297  ? 1354 ILE   B CB   1 
ATOM   4541 C  CG1  . ILE   B 2 302 ? 1.82998   -23.92253 -29.12801 1.000 27.06729  ? 1354 ILE   B CG1  1 
ATOM   4542 C  CG2  . ILE   B 2 302 ? -0.71904  -24.16434 -29.11690 1.000 23.95438  ? 1354 ILE   B CG2  1 
ATOM   4543 C  CD1  . ILE   B 2 302 ? 2.14787   -24.78565 -30.32696 1.000 36.09826  ? 1354 ILE   B CD1  1 
ATOM   4544 N  N    . PHE   B 2 303 ? -1.70786  -23.01305 -26.30096 1.000 25.22467  ? 1355 PHE   B N    1 
ATOM   4545 C  CA   . PHE   B 2 303 ? -3.03885  -23.18891 -25.74590 1.000 27.63076  ? 1355 PHE   B CA   1 
ATOM   4546 C  C    . PHE   B 2 303 ? -4.06692  -23.60492 -26.77883 1.000 27.49469  ? 1355 PHE   B C    1 
ATOM   4547 O  O    . PHE   B 2 303 ? -4.92297  -24.43683 -26.47973 1.000 26.15800  ? 1355 PHE   B O    1 
ATOM   4548 C  CB   . PHE   B 2 303 ? -3.49773  -21.90082 -25.05898 1.000 26.98476  ? 1355 PHE   B CB   1 
ATOM   4549 C  CG   . PHE   B 2 303 ? -3.05967  -21.81674 -23.62900 1.000 28.21788  ? 1355 PHE   B CG   1 
ATOM   4550 C  CD1  . PHE   B 2 303 ? -1.72765  -21.59181 -23.31607 1.000 26.49368  ? 1355 PHE   B CD1  1 
ATOM   4551 C  CD2  . PHE   B 2 303 ? -3.96965  -22.00859 -22.60096 1.000 27.91147  ? 1355 PHE   B CD2  1 
ATOM   4552 C  CE1  . PHE   B 2 303 ? -1.30960  -21.53674 -21.99309 1.000 30.76023  ? 1355 PHE   B CE1  1 
ATOM   4553 C  CE2  . PHE   B 2 303 ? -3.55960  -21.95352 -21.27198 1.000 29.24105  ? 1355 PHE   B CE2  1 
ATOM   4554 C  CZ   . PHE   B 2 303 ? -2.22857  -21.71659 -20.97704 1.000 29.36956  ? 1355 PHE   B CZ   1 
ATOM   4555 N  N    . ASP   B 2 304 ? -4.01092  -23.04702 -27.98787 1.000 27.05288  ? 1356 ASP   B N    1 
ATOM   4556 C  CA   . ASP   B 2 304 ? -5.00998  -23.33602 -29.01082 1.000 26.09191  ? 1356 ASP   B CA   1 
ATOM   4557 C  C    . ASP   B 2 304 ? -4.44499  -22.88317 -30.34687 1.000 25.15849  ? 1356 ASP   B C    1 
ATOM   4558 O  O    . ASP   B 2 304 ? -3.47394  -22.13024 -30.39297 1.000 26.75626  ? 1356 ASP   B O    1 
ATOM   4559 C  CB   . ASP   B 2 304 ? -6.33691  -22.61891 -28.71482 1.000 25.07400  ? 1356 ASP   B CB   1 
ATOM   4560 C  CG   . ASP   B 2 304 ? -7.55199  -23.35486 -29.28172 1.000 25.56184  ? 1356 ASP   B CG   1 
ATOM   4561 O  OD1  . ASP   B 2 304 ? -7.42609  -24.50991 -29.75064 1.000 23.71271  ? 1356 ASP   B OD1  1 
ATOM   4562 O  OD2  . ASP   B 2 304 ? -8.64294  -22.76478 -29.24973 1.000 24.00981  ? 1356 ASP   B OD2  1 
ATOM   4563 N  N    . LEU   B 2 305 ? -5.06306  -23.35021 -31.43381 1.000 22.70440  ? 1357 LEU   B N    1 
ATOM   4564 C  CA   . LEU   B 2 305 ? -4.82007  -22.76233 -32.74087 1.000 26.63430  ? 1357 LEU   B CA   1 
ATOM   4565 C  C    . LEU   B 2 305 ? -6.03312  -22.99132 -33.61981 1.000 25.96279  ? 1357 LEU   B C    1 
ATOM   4566 O  O    . LEU   B 2 305 ? -6.82218  -23.91724 -33.41070 1.000 30.37418  ? 1357 LEU   B O    1 
ATOM   4567 C  CB   . LEU   B 2 305 ? -3.55513  -23.30548 -33.41587 1.000 30.75382  ? 1357 LEU   B CB   1 
ATOM   4568 C  CG   . LEU   B 2 305 ? -3.41025  -24.72353 -33.95276 1.000 30.87811  ? 1357 LEU   B CG   1 
ATOM   4569 C  CD1  . LEU   B 2 305 ? -4.23832  -24.97157 -35.21071 1.000 30.49194  ? 1357 LEU   B CD1  1 
ATOM   4570 C  CD2  . LEU   B 2 305 ? -1.94328  -24.96566 -34.24280 1.000 31.31129  ? 1357 LEU   B CD2  1 
ATOM   4571 N  N    . CYS   B 2 306 ? -6.17609  -22.12038 -34.60287 1.000 25.28629  ? 1358 CYS   B N    1 
ATOM   4572 C  CA   . CYS   B 2 306 ? -7.28513  -22.22138 -35.53282 1.000 25.51345  ? 1358 CYS   B CA   1 
ATOM   4573 C  C    . CYS   B 2 306 ? -6.86613  -21.54651 -36.82389 1.000 29.01630  ? 1358 CYS   B C    1 
ATOM   4574 O  O    . CYS   B 2 306 ? -5.87907  -20.80358 -36.86598 1.000 28.33304  ? 1358 CYS   B O    1 
ATOM   4575 C  CB   . CYS   B 2 306 ? -8.54806  -21.58024 -34.95983 1.000 27.74194  ? 1358 CYS   B CB   1 
ATOM   4576 S  SG   . CYS   B 2 306 ? -8.38692  -19.78223 -34.72498 1.000 27.87415  ? 1358 CYS   B SG   1 
ATOM   4577 N  N    . THR   B 2 307 ? -7.62818  -21.81754 -37.87584 1.000 30.46191  ? 1359 THR   B N    1 
ATOM   4578 C  CA   . THR   B 2 307 ? -7.45718  -21.16165 -39.16290 1.000 31.04250  ? 1359 THR   B CA   1 
ATOM   4579 C  C    . THR   B 2 307 ? -8.80015  -20.58459 -39.57690 1.000 30.67138  ? 1359 THR   B C    1 
ATOM   4580 O  O    . THR   B 2 307 ? -9.85217  -21.01847 -39.09283 1.000 31.90577  ? 1359 THR   B O    1 
ATOM   4581 C  CB   . THR   B 2 307 ? -6.95629  -22.11777 -40.24884 1.000 28.52149  ? 1359 THR   B CB   1 
ATOM   4582 O  OG1  . THR   B 2 307 ? -7.98137  -23.07272 -40.53173 1.000 33.65225  ? 1359 THR   B OG1  1 
ATOM   4583 C  CG2  . THR   B 2 307 ? -5.71933  -22.84883 -39.78083 1.000 33.07899  ? 1359 THR   B CG2  1 
ATOM   4584 N  N    . ASP   B 2 308 ? -8.74911  -19.58166 -40.45398 1.000 29.73814  ? 1360 ASP   B N    1 
ATOM   4585 C  CA   . ASP   B 2 308 ? -9.95209  -18.94761 -40.98199 1.000 32.27203  ? 1360 ASP   B CA   1 
ATOM   4586 C  C    . ASP   B 2 308 ? -10.53919 -19.79066 -42.11490 1.000 35.40444  ? 1360 ASP   B C    1 
ATOM   4587 O  O    . ASP   B 2 308 ? -9.86927  -20.65176 -42.68685 1.000 31.79821  ? 1360 ASP   B O    1 
ATOM   4588 C  CB   . ASP   B 2 308 ? -9.64700  -17.52768 -41.47811 1.000 32.35756  ? 1360 ASP   B CB   1 
ATOM   4589 C  CG   . ASP   B 2 308 ? -8.66904  -17.50184 -42.66515 1.000 34.60591  ? 1360 ASP   B CG   1 
ATOM   4590 O  OD1  . ASP   B 2 308 ? -7.57008  -18.07491 -42.56014 1.000 35.73201  ? 1360 ASP   B OD1  1 
ATOM   4591 O  OD2  . ASP   B 2 308 ? -9.00204  -16.90590 -43.71418 1.000 42.01242  ? 1360 ASP   B OD2  1 
ATOM   4592 N  N    . THR   B 2 309 ? -11.80518 -19.52560 -42.44587 1.000 32.35963  ? 1361 THR   B N    1 
ATOM   4593 C  CA   . THR   B 2 309 ? -12.50728 -20.38862 -43.39378 1.000 34.51977  ? 1361 THR   B CA   1 
ATOM   4594 C  C    . THR   B 2 309 ? -11.78633 -20.47278 -44.73080 1.000 36.37846  ? 1361 THR   B C    1 
ATOM   4595 O  O    . THR   B 2 309 ? -11.92843 -21.47282 -45.44272 1.000 38.84060  ? 1361 THR   B O    1 
ATOM   4596 C  CB   . THR   B 2 309 ? -13.93225 -19.89553 -43.61777 1.000 36.57839  ? 1361 THR   B CB   1 
ATOM   4597 O  OG1  . THR   B 2 309 ? -13.88918 -18.62759 -44.27587 1.000 42.84115  ? 1361 THR   B OG1  1 
ATOM   4598 C  CG2  . THR   B 2 309 ? -14.66619 -19.74738 -42.29275 1.000 31.97499  ? 1361 THR   B CG2  1 
ATOM   4599 N  N    . LYS   B 2 310 ? -11.01327 -19.44686 -45.08991 1.000 37.94849  ? 1362 LYS   B N    1 
ATOM   4600 C  CA   . LYS   B 2 310 ? -10.24531 -19.43502 -46.32594 1.000 37.32699  ? 1362 LYS   B CA   1 
ATOM   4601 C  C    . LYS   B 2 310 ? -8.83634  -19.97010 -46.15195 1.000 33.24342  ? 1362 LYS   B C    1 
ATOM   4602 O  O    . LYS   B 2 310 ? -8.10139  -20.08323 -47.13596 1.000 35.75398  ? 1362 LYS   B O    1 
ATOM   4603 C  CB   . LYS   B 2 310 ? -10.18423 -18.00907 -46.89505 1.000 42.50386  ? 1362 LYS   B CB   1 
ATOM   4604 C  CG   . LYS   B 2 310 ? -11.53620 -17.45500 -47.31105 1.000 45.47754  ? 1362 LYS   B CG   1 
ATOM   4605 C  CD   . LYS   B 2 310 ? -12.10030 -18.20505 -48.50897 1.000 56.18455  ? 1362 LYS   B CD   1 
ATOM   4606 C  CE   . LYS   B 2 310 ? -13.56128 -17.83697 -48.77095 1.000 62.70399  ? 1362 LYS   B CE   1 
ATOM   4607 N  NZ   . LYS   B 2 310 ? -14.50930 -18.54283 -47.84486 1.000 58.66814  ? 1362 LYS   B NZ   1 
ATOM   4608 N  N    . ASP   B 2 311 ? -8.43332  -20.29604 -44.92393 1.000 35.94102  ? 1363 ASP   B N    1 
ATOM   4609 C  CA   . ASP   B 2 311 ? -7.09035  -20.81011 -44.66794 1.000 33.03221  ? 1363 ASP   B CA   1 
ATOM   4610 C  C    . ASP   B 2 311 ? -6.01030  -19.86523 -45.18505 1.000 31.60103  ? 1363 ASP   B C    1 
ATOM   4611 O  O    . ASP   B 2 311 ? -4.94935  -20.29435 -45.64706 1.000 34.23514  ? 1363 ASP   B O    1 
ATOM   4612 C  CB   . ASP   B 2 311 ? -6.93747  -22.21417 -45.24684 1.000 30.88446  ? 1363 ASP   B CB   1 
ATOM   4613 C  CG   . ASP   B 2 311 ? -7.72752  -23.22805 -44.44873 1.000 35.67676  ? 1363 ASP   B CG   1 
ATOM   4614 O  OD1  . ASP   B 2 311 ? -7.37549  -23.45698 -43.27072 1.000 34.60006  ? 1363 ASP   B OD1  1 
ATOM   4615 O  OD2  . ASP   B 2 311 ? -8.72458  -23.74802 -44.96865 1.000 39.39822  ? 1363 ASP   B OD2  1 
ATOM   4616 N  N    . CYS   B 2 312 ? -6.28720  -18.56320 -45.08315 1.000 33.06470  ? 1364 CYS   B N    1 
ATOM   4617 C  CA   . CYS   B 2 312 ? -5.26114  -17.53929 -45.25026 1.000 33.17027  ? 1364 CYS   B CA   1 
ATOM   4618 C  C    . CYS   B 2 312 ? -4.39808  -17.39825 -44.00331 1.000 34.26682  ? 1364 CYS   B C    1 
ATOM   4619 O  O    . CYS   B 2 312 ? -3.17907  -17.19035 -44.10537 1.000 36.22751  ? 1364 CYS   B O    1 
ATOM   4620 C  CB   . CYS   B 2 312 ? -5.91805  -16.19927 -45.58335 1.000 35.68004  ? 1364 CYS   B CB   1 
ATOM   4621 S  SG   . CYS   B 2 312 ? -6.81511  -16.23133 -47.15931 1.000 52.15582  ? 1364 CYS   B SG   1 
ATOM   4622 N  N    . TYR   B 2 313 ? -5.00905  -17.54212 -42.82127 1.000 32.38051  ? 1365 TYR   B N    1 
ATOM   4623 C  CA   . TYR   B 2 313 ? -4.37398  -17.18706 -41.56432 1.000 29.88545  ? 1365 TYR   B CA   1 
ATOM   4624 C  C    . TYR   B 2 313 ? -4.47203  -18.33198 -40.57223 1.000 34.17266  ? 1365 TYR   B C    1 
ATOM   4625 O  O    . TYR   B 2 313 ? -5.43308  -19.10291 -40.57614 1.000 31.07731  ? 1365 TYR   B O    1 
ATOM   4626 C  CB   . TYR   B 2 313 ? -5.00787  -15.94197 -40.96040 1.000 33.87736  ? 1365 TYR   B CB   1 
ATOM   4627 C  CG   . TYR   B 2 313 ? -4.84481  -14.72205 -41.83750 1.000 34.73104  ? 1365 TYR   B CG   1 
ATOM   4628 C  CD1  . TYR   B 2 313 ? -3.60077  -14.12215 -41.99859 1.000 33.18258  ? 1365 TYR   B CD1  1 
ATOM   4629 C  CD2  . TYR   B 2 313 ? -5.92879  -14.16903 -42.51351 1.000 40.47602  ? 1365 TYR   B CD2  1 
ATOM   4630 C  CE1  . TYR   B 2 313 ? -3.43872  -12.99523 -42.81869 1.000 38.48968  ? 1365 TYR   B CE1  1 
ATOM   4631 C  CE2  . TYR   B 2 313 ? -5.77374  -13.03510 -43.33260 1.000 43.97812  ? 1365 TYR   B CE2  1 
ATOM   4632 C  CZ   . TYR   B 2 313 ? -4.52571  -12.46020 -43.47469 1.000 41.00998  ? 1365 TYR   B CZ   1 
ATOM   4633 O  OH   . TYR   B 2 313 ? -4.35465  -11.34328 -44.28679 1.000 46.55332  ? 1365 TYR   B OH   1 
ATOM   4634 N  N    . LEU   B 2 314 ? -3.44400  -18.42599 -39.74126 1.000 28.93137  ? 1366 LEU   B N    1 
ATOM   4635 C  CA   . LEU   B 2 314 ? -3.37903  -19.31790 -38.60119 1.000 30.45463  ? 1366 LEU   B CA   1 
ATOM   4636 C  C    . LEU   B 2 314 ? -3.24492  -18.45581 -37.35326 1.000 31.69114  ? 1366 LEU   B C    1 
ATOM   4637 O  O    . LEU   B 2 314 ? -2.30686  -17.65887 -37.25336 1.000 28.32972  ? 1366 LEU   B O    1 
ATOM   4638 C  CB   . LEU   B 2 314 ? -2.18010  -20.26100 -38.72916 1.000 30.54641  ? 1366 LEU   B CB   1 
ATOM   4639 C  CG   . LEU   B 2 314 ? -1.88412  -21.16292 -37.53110 1.000 29.01669  ? 1366 LEU   B CG   1 
ATOM   4640 C  CD1  . LEU   B 2 314 ? -2.91420  -22.25285 -37.48598 1.000 32.81922  ? 1366 LEU   B CD1  1 
ATOM   4641 C  CD2  . LEU   B 2 314 ? -0.47917  -21.75503 -37.58310 1.000 29.57147  ? 1366 LEU   B CD2  1 
ATOM   4642 N  N    . ALA   B 2 315 ? -4.16790  -18.61267 -36.40322 1.000 26.89383  ? 1367 ALA   B N    1 
ATOM   4643 C  CA   . ALA   B 2 315 ? -4.04981  -17.97758 -35.09827 1.000 23.93771  ? 1367 ALA   B CA   1 
ATOM   4644 C  C    . ALA   B 2 315 ? -3.64984  -19.02352 -34.07020 1.000 26.89384  ? 1367 ALA   B C    1 
ATOM   4645 O  O    . ALA   B 2 315 ? -4.26592  -20.09247 -33.99910 1.000 25.95415  ? 1367 ALA   B O    1 
ATOM   4646 C  CB   . ALA   B 2 315 ? -5.36074  -17.29945 -34.68428 1.000 23.49122  ? 1367 ALA   B CB   1 
ATOM   4647 N  N    . VAL   B 2 316 ? -2.62079  -18.71054 -33.28727 1.000 23.98393  ? 1368 VAL   B N    1 
ATOM   4648 C  CA   . VAL   B 2 316 ? -2.09282  -19.57849 -32.23722 1.000 24.12440  ? 1368 VAL   B CA   1 
ATOM   4649 C  C    . VAL   B 2 316 ? -2.06272  -18.79539 -30.93128 1.000 30.22794  ? 1368 VAL   B C    1 
ATOM   4650 O  O    . VAL   B 2 316 ? -1.54663  -17.67442 -30.88039 1.000 29.59619  ? 1368 VAL   B O    1 
ATOM   4651 C  CB   . VAL   B 2 316 ? -0.68087  -20.08862 -32.57423 1.000 27.50786  ? 1368 VAL   B CB   1 
ATOM   4652 C  CG1  . VAL   B 2 316 ? -0.20390  -21.10157 -31.52216 1.000 24.65708  ? 1368 VAL   B CG1  1 
ATOM   4653 C  CG2  . VAL   B 2 316 ? -0.64396  -20.67073 -33.99918 1.000 27.68889  ? 1368 VAL   B CG2  1 
ATOM   4654 N  N    . ILE   B 2 317 ? -2.61172  -19.37827 -29.87621 1.000 27.91092  ? 1369 ILE   B N    1 
ATOM   4655 C  CA   . ILE   B 2 317 ? -2.49563  -18.80817 -28.54226 1.000 26.19394  ? 1369 ILE   B CA   1 
ATOM   4656 C  C    . ILE   B 2 317 ? -1.26065  -19.40521 -27.89126 1.000 29.43149  ? 1369 ILE   B C    1 
ATOM   4657 O  O    . ILE   B 2 317 ? -1.16873  -20.62620 -27.72717 1.000 28.92399  ? 1369 ILE   B O    1 
ATOM   4658 C  CB   . ILE   B 2 317 ? -3.74962  -19.07601 -27.70320 1.000 25.31019  ? 1369 ILE   B CB   1 
ATOM   4659 C  CG1  . ILE   B 2 317 ? -4.95060  -18.40498 -28.36821 1.000 28.81804  ? 1369 ILE   B CG1  1 
ATOM   4660 C  CG2  . ILE   B 2 317 ? -3.53453  -18.54692 -26.28525 1.000 25.71771  ? 1369 ILE   B CG2  1 
ATOM   4661 C  CD1  . ILE   B 2 317 ? -6.22558  -18.58683 -27.60415 1.000 29.66836  ? 1369 ILE   B CD1  1 
ATOM   4662 N  N    . GLU   B 2 318 ? -0.30358  -18.55125 -27.54936 1.000 29.15825  ? 1370 GLU   B N    1 
ATOM   4663 C  CA   . GLU   B 2 318 ? 1.00741   -18.97831 -27.09337 1.000 27.86024  ? 1370 GLU   B CA   1 
ATOM   4664 C  C    . GLU   B 2 318 ? 1.30650   -18.34222 -25.74744 1.000 28.20815  ? 1370 GLU   B C    1 
ATOM   4665 O  O    . GLU   B 2 318 ? 0.94459   -17.19218 -25.49251 1.000 31.97875  ? 1370 GLU   B O    1 
ATOM   4666 C  CB   . GLU   B 2 318 ? 2.10540   -18.61047 -28.09644 1.000 31.02906  ? 1370 GLU   B CB   1 
ATOM   4667 C  CG   . GLU   B 2 318 ? 1.88231   -19.18656 -29.48039 1.000 30.73949  ? 1370 GLU   B CG   1 
ATOM   4668 C  CD   . GLU   B 2 318 ? 2.93730   -18.74071 -30.45546 1.000 39.85105  ? 1370 GLU   B CD   1 
ATOM   4669 O  OE1  . GLU   B 2 318 ? 3.93136   -18.14775 -29.98154 1.000 36.23040  ? 1370 GLU   B OE1  1 
ATOM   4670 O  OE2  . GLU   B 2 318 ? 2.76824   -18.97580 -31.68744 1.000 37.19433  ? 1370 GLU   B OE2  1 
ATOM   4671 N  N    . ASN   B 2 319 ? 1.95048   -19.10720 -24.88340 1.000 27.07162  ? 1371 ASN   B N    1 
ATOM   4672 C  CA   . ASN   B 2 319 ? 2.30056   -18.62512 -23.56145 1.000 31.20450  ? 1371 ASN   B CA   1 
ATOM   4673 C  C    . ASN   B 2 319 ? 3.65161   -17.93123 -23.63755 1.000 31.28541  ? 1371 ASN   B C    1 
ATOM   4674 O  O    . ASN   B 2 319 ? 4.57555   -18.44534 -24.27254 1.000 38.34276  ? 1371 ASN   B O    1 
ATOM   4675 C  CB   . ASN   B 2 319 ? 2.36151   -19.78705 -22.57636 1.000 33.96551  ? 1371 ASN   B CB   1 
ATOM   4676 C  CG   . ASN   B 2 319 ? 2.22959   -19.33693 -21.14539 1.000 38.53805  ? 1371 ASN   B CG   1 
ATOM   4677 O  OD1  . ASN   B 2 319 ? 1.56868   -18.34186 -20.85745 1.000 35.33339  ? 1371 ASN   B OD1  1 
ATOM   4678 N  ND2  . ASN   B 2 319 ? 2.86357   -20.07290 -20.23335 1.000 44.10611  ? 1371 ASN   B ND2  1 
ATOM   4679 N  N    . GLN   B 2 320 ? 3.75571   -16.75518 -23.01965 1.000 34.74147  ? 1372 GLN   B N    1 
ATOM   4680 C  CA   . GLN   B 2 320 ? 5.04677   -16.08827 -22.89475 1.000 41.72425  ? 1372 GLN   B CA   1 
ATOM   4681 C  C    . GLN   B 2 320 ? 5.86176   -16.74824 -21.78872 1.000 44.32962  ? 1372 GLN   B C    1 
ATOM   4682 O  O    . GLN   B 2 320 ? 5.34778   -16.99011 -20.68769 1.000 47.93572  ? 1372 GLN   B O    1 
ATOM   4683 C  CB   . GLN   B 2 320 ? 4.87789   -14.60323 -22.57586 1.000 39.02966  ? 1372 GLN   B CB   1 
ATOM   4684 C  CG   . GLN   B 2 320 ? 4.10591   -13.81826 -23.59889 1.000 36.71185  ? 1372 GLN   B CG   1 
ATOM   4685 C  CD   . GLN   B 2 320 ? 4.55801   -12.37429 -23.62202 1.000 39.03190  ? 1372 GLN   B CD   1 
ATOM   4686 O  OE1  . GLN   B 2 320 ? 5.68602   -12.09240 -24.00609 1.000 38.50825  ? 1372 GLN   B OE1  1 
ATOM   4687 N  NE2  . GLN   B 2 320 ? 3.69209   -11.45719 -23.19607 1.000 33.30835  ? 1372 GLN   B NE2  1 
ATOM   4688 N  N    . GLY   B 2 321 ? 7.12673   -17.03035 -22.08275 1.000 49.65235  ? 1373 GLY   B N    1 
ATOM   4689 C  CA   . GLY   B 2 321 ? 8.03372   -17.59934 -21.09373 1.000 57.04387  ? 1373 GLY   B CA   1 
ATOM   4690 C  C    . GLY   B 2 321 ? 8.54461   -18.99240 -21.43064 1.000 61.67989  ? 1373 GLY   B C    1 
ATOM   4691 O  O    . GLY   B 2 321 ? 7.87153   -19.77541 -22.11056 1.000 58.14227  ? 1373 GLY   B O    1 
ATOM   4692 N  N    . ASN   B 2 327 ? 4.13275   -19.94261 -15.42041 1.000 50.26714  ? 1379 ASN   B N    1 
ATOM   4693 C  CA   . ASN   B 2 327 ? 3.18784   -18.83853 -15.20846 1.000 54.14531  ? 1379 ASN   B CA   1 
ATOM   4694 C  C    . ASN   B 2 327 ? 2.43082   -18.48457 -16.49246 1.000 53.76310  ? 1379 ASN   B C    1 
ATOM   4695 O  O    . ASN   B 2 327 ? 3.03979   -18.36370 -17.56350 1.000 53.76431  ? 1379 ASN   B O    1 
ATOM   4696 C  CB   . ASN   B 2 327 ? 3.91295   -17.59954 -14.68259 1.000 53.70474  ? 1379 ASN   B CB   1 
ATOM   4697 C  CG   . ASN   B 2 327 ? 2.99904   -16.69741 -13.88063 1.000 61.20755  ? 1379 ASN   B CG   1 
ATOM   4698 O  OD1  . ASN   B 2 327 ? 2.39509   -15.77241 -14.42068 1.000 64.22311  ? 1379 ASN   B OD1  1 
ATOM   4699 N  ND2  . ASN   B 2 327 ? 2.87407   -16.97729 -12.57960 1.000 65.84604  ? 1379 ASN   B ND2  1 
ATOM   4700 N  N    . MET   B 2 328 ? 1.11184   -18.30147 -16.39743 1.000 45.23852  ? 1380 MET   B N    1 
ATOM   4701 C  CA   . MET   B 2 328 ? 0.29181   -18.09950 -17.58742 1.000 42.25466  ? 1380 MET   B CA   1 
ATOM   4702 C  C    . MET   B 2 328 ? 0.23590   -16.62653 -17.97653 1.000 40.26126  ? 1380 MET   B C    1 
ATOM   4703 O  O    . MET   B 2 328 ? -0.20301  -15.77744 -17.19058 1.000 40.11194  ? 1380 MET   B O    1 
ATOM   4704 C  CB   . MET   B 2 328 ? -1.12522  -18.63039 -17.40433 1.000 43.21062  ? 1380 MET   B CB   1 
ATOM   4705 C  CG   . MET   B 2 328 ? -1.91426  -18.55843 -18.72130 1.000 35.41908  ? 1380 MET   B CG   1 
ATOM   4706 S  SD   . MET   B 2 328 ? -3.63228  -18.96029 -18.50621 1.000 39.72349  ? 1380 MET   B SD   1 
ATOM   4707 C  CE   . MET   B 2 328 ? -4.33230  -18.44037 -20.06623 1.000 33.78213  ? 1380 MET   B CE   1 
ATOM   4708 N  N    . ASP   B 2 329 ? 0.63588   -16.34166 -19.21457 1.000 38.38405  ? 1381 ASP   B N    1 
ATOM   4709 C  CA   . ASP   B 2 329 ? 0.66496   -14.97370 -19.72868 1.000 38.51332  ? 1381 ASP   B CA   1 
ATOM   4710 C  C    . ASP   B 2 329 ? 0.70689   -15.12182 -21.25467 1.000 31.90076  ? 1381 ASP   B C    1 
ATOM   4711 O  O    . ASP   B 2 329 ? 1.78187   -15.15595 -21.85770 1.000 33.72794  ? 1381 ASP   B O    1 
ATOM   4712 C  CB   . ASP   B 2 329 ? 1.85903   -14.21874 -19.17278 1.000 37.98813  ? 1381 ASP   B CB   1 
ATOM   4713 C  CG   . ASP   B 2 329 ? 1.90912   -12.76878 -19.62090 1.000 41.58708  ? 1381 ASP   B CG   1 
ATOM   4714 O  OD1  . ASP   B 2 329 ? 0.84416   -12.15773 -19.90491 1.000 35.69110  ? 1381 ASP   B OD1  1 
ATOM   4715 O  OD2  . ASP   B 2 329 ? 3.04616   -12.24787 -19.69998 1.000 44.94746  ? 1381 ASP   B OD2  1 
ATOM   4716 N  N    . THR   B 2 330 ? -0.47114  -15.25779 -21.85662 1.000 28.21802  ? 1382 THR   B N    1 
ATOM   4717 C  CA   . THR   B 2 330 ? -0.57022  -15.71289 -23.23558 1.000 28.72598  ? 1382 THR   B CA   1 
ATOM   4718 C  C    . THR   B 2 330 ? -0.70717  -14.54896 -24.21366 1.000 29.31495  ? 1382 THR   B C    1 
ATOM   4719 O  O    . THR   B 2 330 ? -1.23708  -13.47889 -23.89173 1.000 27.92122  ? 1382 THR   B O    1 
ATOM   4720 C  CB   . THR   B 2 330 ? -1.76129  -16.66082 -23.43846 1.000 26.91256  ? 1382 THR   B CB   1 
ATOM   4721 O  OG1  . THR   B 2 330 ? -2.96023  -16.03369 -22.96147 1.000 27.37760  ? 1382 THR   B OG1  1 
ATOM   4722 C  CG2  . THR   B 2 330 ? -1.52737  -18.02078 -22.73436 1.000 28.22235  ? 1382 THR   B CG2  1 
ATOM   4723 N  N    . VAL   B 2 331 ? -0.24923  -14.79109 -25.43366 1.000 26.60430  ? 1383 VAL   B N    1 
ATOM   4724 C  CA   . VAL   B 2 331 ? -0.50220  -13.87315 -26.52672 1.000 27.45839  ? 1383 VAL   B CA   1 
ATOM   4725 C  C    . VAL   B 2 331 ? -1.17830  -14.66719 -27.62364 1.000 28.18733  ? 1383 VAL   B C    1 
ATOM   4726 O  O    . VAL   B 2 331 ? -1.09439  -15.89420 -27.67354 1.000 27.04382  ? 1383 VAL   B O    1 
ATOM   4727 C  CB   . VAL   B 2 331 ? 0.78583   -13.21129 -27.04782 1.000 28.10331  ? 1383 VAL   B CB   1 
ATOM   4728 C  CG1  . VAL   B 2 331 ? 1.51892   -12.53225 -25.87890 1.000 28.68780  ? 1383 VAL   B CG1  1 
ATOM   4729 C  CG2  . VAL   B 2 331 ? 1.68873   -14.25441 -27.72477 1.000 25.06364  ? 1383 VAL   B CG2  1 
ATOM   4730 N  N    . CYS   B 2 332 ? -1.85828  -13.95021 -28.50667 1.000 27.46818  ? 1384 CYS   B N    1 
ATOM   4731 C  CA   . CYS   B 2 332 ? -2.34836  -14.51128 -29.75461 1.000 27.40562  ? 1384 CYS   B CA   1 
ATOM   4732 C  C    . CYS   B 2 332 ? -1.40537  -14.06043 -30.85568 1.000 29.94758  ? 1384 CYS   B C    1 
ATOM   4733 O  O    . CYS   B 2 332 ? -1.16229  -12.85546 -31.01278 1.000 30.50599  ? 1384 CYS   B O    1 
ATOM   4734 C  CB   . CYS   B 2 332 ? -3.77034  -14.05820 -30.05259 1.000 24.28919  ? 1384 CYS   B CB   1 
ATOM   4735 S  SG   . CYS   B 2 332 ? -4.31144  -14.65228 -31.65253 1.000 27.77707  ? 1384 CYS   B SG   1 
ATOM   4736 N  N    . ARG   B 2 333 ? -0.83447  -15.01753 -31.57362 1.000 25.06714  ? 1385 ARG   B N    1 
ATOM   4737 C  CA   . ARG   B 2 333 ? 0.00951   -14.72768 -32.71968 1.000 28.71510  ? 1385 ARG   B CA   1 
ATOM   4738 C  C    . ARG   B 2 333 ? -0.68956  -15.17173 -33.99162 1.000 30.88702  ? 1385 ARG   B C    1 
ATOM   4739 O  O    . ARG   B 2 333 ? -1.16565  -16.31070 -34.08651 1.000 31.45426  ? 1385 ARG   B O    1 
ATOM   4740 C  CB   . ARG   B 2 333 ? 1.36847   -15.40777 -32.59367 1.000 32.62444  ? 1385 ARG   B CB   1 
ATOM   4741 C  CG   . ARG   B 2 333 ? 2.23755   -14.73875 -31.57075 1.000 39.84421  ? 1385 ARG   B CG   1 
ATOM   4742 C  CD   . ARG   B 2 333 ? 3.55251   -15.41984 -31.44275 1.000 44.69456  ? 1385 ARG   B CD   1 
ATOM   4743 N  NE   . ARG   B 2 333 ? 4.42348   -15.21699 -32.58879 1.000 44.27073  ? 1385 ARG   B NE   1 
ATOM   4744 C  CZ   . ARG   B 2 333 ? 5.38455   -14.30506 -32.64390 1.000 51.17225  ? 1385 ARG   B CZ   1 
ATOM   4745 N  NH1  . ARG   B 2 333 ? 5.58364   -13.45200 -31.64598 1.000 47.57353  ? 1385 ARG   B NH1  1 
ATOM   4746 N  NH2  . ARG   B 2 333 ? 6.16551   -14.24921 -33.72193 1.000 45.07400  ? 1385 ARG   B NH2  1 
ATOM   4747 N  N    . LEU   B 2 334 ? -0.76453  -14.26080 -34.94868 1.000 29.46826  ? 1386 LEU   B N    1 
ATOM   4748 C  CA   . LEU   B 2 334 ? -1.38560  -14.50286 -36.23864 1.000 29.51012  ? 1386 LEU   B CA   1 
ATOM   4749 C  C    . LEU   B 2 334 ? -0.29265  -14.76602 -37.26266 1.000 32.01483  ? 1386 LEU   B C    1 
ATOM   4750 O  O    . LEU   B 2 334 ? 0.67040   -14.00010 -37.35076 1.000 32.11220  ? 1386 LEU   B O    1 
ATOM   4751 C  CB   . LEU   B 2 334 ? -2.20952  -13.29683 -36.65671 1.000 27.44723  ? 1386 LEU   B CB   1 
ATOM   4752 C  CG   . LEU   B 2 334 ? -3.02358  -13.48787 -37.92367 1.000 33.92938  ? 1386 LEU   B CG   1 
ATOM   4753 C  CD1  . LEU   B 2 334 ? -4.17864  -14.43977 -37.64555 1.000 28.74372  ? 1386 LEU   B CD1  1 
ATOM   4754 C  CD2  . LEU   B 2 334 ? -3.51050  -12.12187 -38.36076 1.000 28.93136  ? 1386 LEU   B CD2  1 
ATOM   4755 N  N    . TYR   B 2 335 ? -0.43276  -15.85307 -38.01457 1.000 30.21119  ? 1387 TYR   B N    1 
ATOM   4756 C  CA   . TYR   B 2 335 ? 0.53718   -16.22222 -39.03158 1.000 31.20531  ? 1387 TYR   B CA   1 
ATOM   4757 C  C    . TYR   B 2 335 ? -0.15088  -16.37628 -40.38054 1.000 35.65836  ? 1387 TYR   B C    1 
ATOM   4758 O  O    . TYR   B 2 335 ? -1.30591  -16.81620 -40.47546 1.000 28.94770  ? 1387 TYR   B O    1 
ATOM   4759 C  CB   . TYR   B 2 335 ? 1.24810   -17.52224 -38.71250 1.000 33.83568  ? 1387 TYR   B CB   1 
ATOM   4760 C  CG   . TYR   B 2 335 ? 1.95714   -17.58319 -37.39552 1.000 34.95620  ? 1387 TYR   B CG   1 
ATOM   4761 C  CD1  . TYR   B 2 335 ? 1.28615   -17.98405 -36.25146 1.000 30.12004  ? 1387 TYR   B CD1  1 
ATOM   4762 C  CD2  . TYR   B 2 335 ? 3.31017   -17.27828 -37.29659 1.000 31.78799  ? 1387 TYR   B CD2  1 
ATOM   4763 C  CE1  . TYR   B 2 335 ? 1.94119   -18.08000 -35.03548 1.000 33.45145  ? 1387 TYR   B CE1  1 
ATOM   4764 C  CE2  . TYR   B 2 335 ? 3.97520   -17.35523 -36.07961 1.000 34.15447  ? 1387 TYR   B CE2  1 
ATOM   4765 C  CZ   . TYR   B 2 335 ? 3.28322   -17.76309 -34.94955 1.000 37.06214  ? 1387 TYR   B CZ   1 
ATOM   4766 O  OH   . TYR   B 2 335 ? 3.91925   -17.85504 -33.73157 1.000 34.83680  ? 1387 TYR   B OH   1 
ATOM   4767 N  N    . GLU   B 2 336 ? 0.58611   -15.99841 -41.41960 1.000 37.37006  ? 1388 GLU   B N    1 
ATOM   4768 C  CA   . GLU   B 2 336 ? 0.14005   -16.17549 -42.79157 1.000 38.09137  ? 1388 GLU   B CA   1 
ATOM   4769 C  C    . GLU   B 2 336 ? 0.37793   -17.61754 -43.21246 1.000 40.75080  ? 1388 GLU   B C    1 
ATOM   4770 O  O    . GLU   B 2 336 ? 1.47890   -18.14960 -43.03646 1.000 43.45448  ? 1388 GLU   B O    1 
ATOM   4771 C  CB   . GLU   B 2 336 ? 0.90309   -15.22361 -43.70567 1.000 44.53258  ? 1388 GLU   B CB   1 
ATOM   4772 C  CG   . GLU   B 2 336 ? 0.30805   -15.01168 -45.07066 1.000 53.08308  ? 1388 GLU   B CG   1 
ATOM   4773 C  CD   . GLU   B 2 336 ? 1.15709   -14.04781 -45.88177 1.000 57.43055  ? 1388 GLU   B CD   1 
ATOM   4774 O  OE1  . GLU   B 2 336 ? 2.36607   -14.34091 -46.04579 1.000 53.53912  ? 1388 GLU   B OE1  1 
ATOM   4775 O  OE2  . GLU   B 2 336 ? 0.62915   -12.99680 -46.31183 1.000 55.33846  ? 1388 GLU   B OE2  1 
ATOM   4776 N  N    . VAL   B 2 337 ? -0.65813  -18.26050 -43.73637 1.000 37.98913  ? 1389 VAL   B N    1 
ATOM   4777 C  CA   . VAL   B 2 337 ? -0.51925  -19.62155 -44.23227 1.000 47.76454  ? 1389 VAL   B CA   1 
ATOM   4778 C  C    . VAL   B 2 337 ? -0.00230  -19.58571 -45.67829 1.000 47.41898  ? 1389 VAL   B C    1 
ATOM   4779 O  O    . VAL   B 2 337 ? -0.63330  -19.11973 -46.62831 1.000 47.52942  ? 1389 VAL   B O    1 
ATOM   4780 C  CB   . VAL   B 2 337 ? -1.84430  -20.37745 -44.13516 1.000 43.55947  ? 1389 VAL   B CB   1 
ATOM   4781 C  CG1  . VAL   B 2 337 ? -1.87042  -21.52453 -45.13607 1.000 51.63993  ? 1389 VAL   B CG1  1 
ATOM   4782 C  CG2  . VAL   B 2 337 ? -2.05529  -20.88932 -42.72911 1.000 40.24631  ? 1389 VAL   B CG2  1 
ATOM   4783 N  N    . GLY   B 2 338 ? 1.22566   -20.05580 -45.78230 1.000 54.02392  ? 1390 GLY   B N    1 
ATOM   4784 C  CA   . GLY   B 2 338 ? 1.83759   -20.36595 -47.06929 1.000 63.69688  ? 1390 GLY   B CA   1 
ATOM   4785 C  C    . GLY   B 2 338 ? 1.73648   -21.85497 -47.38217 1.000 70.56993  ? 1390 GLY   B C    1 
ATOM   4786 O  O    . GLY   B 2 338 ? 2.02245   -22.67291 -46.45012 1.000 71.02763  ? 1390 GLY   B O    1 
ATOM   4787 O  OXT  . GLY   B 2 338 ? 1.39041   -22.24203 -48.49913 1.000 80.63793  ? 1390 GLY   B OXT  1 
HETATM 4788 C  C01  . A1ANM C 3 .   ? -8.72488  -24.63111 4.37142   1.000 24.75396  ? 1401 A1ANM A C01  1 
HETATM 4789 C  C03  . A1ANM C 3 .   ? -10.50996 -25.23607 3.27153   1.000 26.88599  ? 1401 A1ANM A C03  1 
HETATM 4790 C  C04  . A1ANM C 3 .   ? -11.33399 -24.98812 1.97854   1.000 22.76516  ? 1401 A1ANM A C04  1 
HETATM 4791 C  C06  . A1ANM C 3 .   ? -11.26609 -25.18532 -0.49245  1.000 23.38771  ? 1401 A1ANM A C06  1 
HETATM 4792 C  C07  . A1ANM C 3 .   ? -12.45404 -24.46623 -0.56046  1.000 25.64856  ? 1401 A1ANM A C07  1 
HETATM 4793 C  C08  . A1ANM C 3 .   ? -13.09507 -24.28529 -1.78645  1.000 26.56674  ? 1401 A1ANM A C08  1 
HETATM 4794 C  C09  . A1ANM C 3 .   ? -12.52915 -24.83342 -2.91643  1.000 27.35548  ? 1401 A1ANM A C09  1 
HETATM 4795 C  C10  . A1ANM C 3 .   ? -13.02519 -24.69348 -4.20642  1.000 31.27898  ? 1401 A1ANM A C10  1 
HETATM 4796 C  C11  . A1ANM C 3 .   ? -14.34521 -24.74542 -4.62237  1.000 23.55091  ? 1401 A1ANM A C11  1 
HETATM 4797 C  C13  . A1ANM C 3 .   ? -14.64124 -24.58050 -5.96737  1.000 31.88735  ? 1401 A1ANM A C13  1 
HETATM 4798 C  C14  . A1ANM C 3 .   ? -13.61326 -24.34965 -6.86643  1.000 33.50800  ? 1401 A1ANM A C14  1 
HETATM 4799 C  C15  . A1ANM C 3 .   ? -12.30324 -24.31471 -6.41148  1.000 37.71318  ? 1401 A1ANM A C15  1 
HETATM 4800 C  C16  . A1ANM C 3 .   ? -11.16526 -24.03587 -7.38054  1.000 42.18656  ? 1401 A1ANM A C16  1 
HETATM 4801 C  C19  . A1ANM C 3 .   ? -8.65622  -23.36809 -7.84568  1.000 54.47039  ? 1401 A1ANM A C19  1 
HETATM 4802 C  C20  . A1ANM C 3 .   ? -8.67930  -23.65720 -9.35866  1.000 58.15009  ? 1401 A1ANM A C20  1 
HETATM 4803 C  C22  . A1ANM C 3 .   ? -9.43647  -25.19927 -10.90751 1.000 61.14264  ? 1401 A1ANM A C22  1 
HETATM 4804 C  C23  . A1ANM C 3 .   ? -8.42946  -24.68543 -11.93059 1.000 64.02520  ? 1401 A1ANM A C23  1 
HETATM 4805 C  C25  . A1ANM C 3 .   ? -6.58156  -25.37166 -13.20960 1.000 64.25989  ? 1401 A1ANM A C25  1 
HETATM 4806 C  C26  . A1ANM C 3 .   ? -5.61765  -26.54874 -13.35254 1.000 67.61509  ? 1401 A1ANM A C26  1 
HETATM 4807 C  C28  . A1ANM C 3 .   ? -5.29783  -28.56285 -14.44739 1.000 66.06529  ? 1401 A1ANM A C28  1 
HETATM 4808 C  C29  . A1ANM C 3 .   ? -4.04182  -28.00099 -15.09648 1.000 67.86926  ? 1401 A1ANM A C29  1 
HETATM 4809 C  C31  . A1ANM C 3 .   ? -4.52697  -29.08712 -17.09838 1.000 58.04021  ? 1401 A1ANM A C31  1 
HETATM 4810 C  C32  . A1ANM C 3 .   ? -4.58200  -28.81523 -18.59640 1.000 52.01833  ? 1401 A1ANM A C32  1 
HETATM 4811 C  C34  . A1ANM C 3 .   ? -6.52501  -28.17720 -20.03838 1.000 42.83920  ? 1401 A1ANM A C34  1 
HETATM 4812 C  C36  . A1ANM C 3 .   ? -7.71395  -27.23414 -20.32441 1.000 38.70659  ? 1401 A1ANM A C36  1 
HETATM 4813 C  C38  . A1ANM C 3 .   ? -7.76202  -27.08033 -22.78142 1.000 28.01248  ? 1401 A1ANM A C38  1 
HETATM 4814 C  C39  . A1ANM C 3 .   ? -8.51810  -27.64136 -23.78735 1.000 27.92935  ? 1401 A1ANM A C39  1 
HETATM 4815 C  C40  . A1ANM C 3 .   ? -8.36113  -27.41248 -25.14937 1.000 27.35824  ? 1401 A1ANM A C40  1 
HETATM 4816 C  C42  . A1ANM C 3 .   ? -7.99212  -26.35665 -26.98847 1.000 27.43422  ? 1401 A1ANM A C42  1 
HETATM 4817 C  C43  . A1ANM C 3 .   ? -8.21723  -27.67066 -27.33236 1.000 25.78840  ? 1401 A1ANM A C43  1 
HETATM 4818 C  C44  . A1ANM C 3 .   ? -8.19632  -28.23777 -28.76931 1.000 26.35877  ? 1401 A1ANM A C44  1 
HETATM 4819 C  C47  . A1ANM C 3 .   ? -7.89839  -27.95099 -31.20535 1.000 23.76683  ? 1401 A1ANM A C47  1 
HETATM 4820 C  C48  . A1ANM C 3 .   ? -8.70235  -27.04400 -32.10939 1.000 25.42829  ? 1401 A1ANM A C48  1 
HETATM 4821 C  C49  . A1ANM C 3 .   ? -10.21437 -27.23189 -32.02532 1.000 30.21837  ? 1401 A1ANM A C49  1 
HETATM 4822 C  C52  . A1ANM C 3 .   ? -6.48041  -28.06713 -31.72039 1.000 27.84135  ? 1401 A1ANM A C52  1 
HETATM 4823 C  C53  . A1ANM C 3 .   ? -5.46234  -27.39816 -31.08048 1.000 27.39411  ? 1401 A1ANM A C53  1 
HETATM 4824 C  C54  . A1ANM C 3 .   ? -4.17337  -27.50929 -31.55851 1.000 27.22690  ? 1401 A1ANM A C54  1 
HETATM 4825 C  C56  . A1ANM C 3 .   ? -3.91746  -28.28439 -32.67646 1.000 26.25244  ? 1401 A1ANM A C56  1 
HETATM 4826 C  C58  . A1ANM C 3 .   ? -4.94054  -28.95137 -33.31337 1.000 26.49528  ? 1401 A1ANM A C58  1 
HETATM 4827 C  C59  . A1ANM C 3 .   ? -6.22851  -28.84424 -32.83534 1.000 26.46710  ? 1401 A1ANM A C59  1 
HETATM 4828 C  C60  . A1ANM C 3 .   ? -8.45424  -28.36055 -26.15629 1.000 29.01221  ? 1401 A1ANM A C60  1 
HETATM 4829 C  C61  . A1ANM C 3 .   ? -8.72633  -29.71752 -25.99618 1.000 28.01607  ? 1401 A1ANM A C61  1 
HETATM 4830 C  C62  . A1ANM C 3 .   ? -7.74837  -30.53155 -25.47715 1.000 27.51294  ? 1401 A1ANM A C62  1 
HETATM 4831 C  C63  . A1ANM C 3 .   ? -7.99246  -31.87351 -25.29803 1.000 29.70720  ? 1401 A1ANM A C63  1 
HETATM 4832 C  C64  . A1ANM C 3 .   ? -9.21951  -32.40845 -25.63895 1.000 32.70495  ? 1401 A1ANM A C64  1 
HETATM 4833 C  C66  . A1ANM C 3 .   ? -10.20347 -31.59742 -26.15898 1.000 27.91085  ? 1401 A1ANM A C66  1 
HETATM 4834 C  C67  . A1ANM C 3 .   ? -9.95938  -30.25346 -26.33909 1.000 30.63826  ? 1401 A1ANM A C67  1 
HETATM 4835 C  C69  . A1ANM C 3 .   ? -9.45114  -28.46124 -23.18025 1.000 30.06748  ? 1401 A1ANM A C69  1 
HETATM 4836 C  C71  . A1ANM C 3 .   ? -12.01020 -24.46963 -5.09448  1.000 28.27830  ? 1401 A1ANM A C71  1 
HETATM 4837 C  C72  . A1ANM C 3 .   ? -11.33920 -25.52050 -2.85042  1.000 26.80910  ? 1401 A1ANM A C72  1 
HETATM 4838 C  C73  . A1ANM C 3 .   ? -10.69917 -25.69045 -1.64143  1.000 27.05787  ? 1401 A1ANM A C73  1 
HETATM 4839 C  C75  . A1ANM C 3 .   ? -8.26222  -26.05968 -2.32948  1.000 25.94335  ? 1401 A1ANM A C75  1 
HETATM 4840 C  C77  . A1ANM C 3 .   ? -7.17830  -27.14275 -2.31044  1.000 28.83851  ? 1401 A1ANM A C77  1 
HETATM 4841 C  C78  . A1ANM C 3 .   ? -5.75327  -26.92483 -1.94450  1.000 29.00192  ? 1401 A1ANM A C78  1 
HETATM 4842 C  C79  . A1ANM C 3 .   ? -5.25316  -25.53683 -1.55363  1.000 28.18237  ? 1401 A1ANM A C79  1 
HETATM 4843 C  C83  . A1ANM C 3 .   ? -4.82336  -28.08790 -1.97045  1.000 29.76888  ? 1401 A1ANM A C83  1 
HETATM 4844 C  C84  . A1ANM C 3 .   ? -5.34347  -29.46889 -2.36432  1.000 32.67465  ? 1401 A1ANM A C84  1 
HETATM 4845 C  C87  . A1ANM C 3 .   ? -7.67341  -28.52475 -2.70331  1.000 31.92065  ? 1401 A1ANM A C87  1 
HETATM 4846 C  C88  . A1ANM C 3 .   ? -9.37300  -24.52735 0.85143   1.000 21.08438  ? 1401 A1ANM A C88  1 
HETATM 4847 C  C89  . A1ANM C 3 .   ? -8.58395  -24.55330 2.18641   1.000 24.50755  ? 1401 A1ANM A C89  1 
HETATM 4848 C  C90  . A1ANM C 3 .   ? -7.61886  -23.32437 2.12728   1.000 23.07080  ? 1401 A1ANM A C90  1 
HETATM 4849 C  C91  . A1ANM C 3 .   ? -11.45489 -24.90491 4.47854   1.000 27.15456  ? 1401 A1ANM A C91  1 
HETATM 4850 F  F12  . A1ANM C 3 .   ? -15.34119 -24.97128 -3.74332  1.000 29.88619  ? 1401 A1ANM A F12  1 
HETATM 4851 F  F57  . A1ANM C 3 .   ? -2.65449  -28.39052 -33.15050 1.000 28.82120  ? 1401 A1ANM A F57  1 
HETATM 4852 F  F68  . A1ANM C 3 .   ? -10.93834 -29.46742 -26.85312 1.000 32.95410  ? 1401 A1ANM A F68  1 
HETATM 4853 F  F80  . A1ANM C 3 .   ? -6.05908  -25.03970 -0.57864  1.000 27.89202  ? 1401 A1ANM A F80  1 
HETATM 4854 F  F81  . A1ANM C 3 .   ? -5.28914  -24.71892 -2.63570  1.000 25.60705  ? 1401 A1ANM A F81  1 
HETATM 4855 F  F82  . A1ANM C 3 .   ? -3.98215  -25.63189 -1.10667  1.000 29.44647  ? 1401 A1ANM A F82  1 
HETATM 4856 N  N02  . A1ANM C 3 .   ? -9.38390  -24.45015 3.30543   1.000 27.94726  ? 1401 A1ANM A N02  1 
HETATM 4857 N  N05  . A1ANM C 3 .   ? -10.58406 -25.34226 0.79554   1.000 28.99397  ? 1401 A1ANM A N05  1 
HETATM 4858 N  N18  . A1ANM C 3 .   ? -9.79922  -23.71793 -6.98161  1.000 51.48302  ? 1401 A1ANM A N18  1 
HETATM 4859 N  N33  . A1ANM C 3 .   ? -5.69595  -27.94117 -18.87843 1.000 52.55228  ? 1401 A1ANM A N33  1 
HETATM 4860 N  N37  . A1ANM C 3 .   ? -8.23602  -27.55421 -21.64437 1.000 32.85762  ? 1401 A1ANM A N37  1 
HETATM 4861 N  N41  . A1ANM C 3 .   ? -8.08407  -26.24854 -25.68348 1.000 26.29366  ? 1401 A1ANM A N41  1 
HETATM 4862 N  N46  . A1ANM C 3 .   ? -7.90030  -27.35188 -29.88039 1.000 26.73376  ? 1401 A1ANM A N46  1 
HETATM 4863 N  N51  . A1ANM C 3 .   ? -11.09933 -26.40088 -32.80636 1.000 33.15222  ? 1401 A1ANM A N51  1 
HETATM 4864 N  N70  . A1ANM C 3 .   ? -9.26009  -28.40315 -21.87926 1.000 27.27823  ? 1401 A1ANM A N70  1 
HETATM 4865 N  N74  . A1ANM C 3 .   ? -9.49623  -26.48354 -1.69941  1.000 25.95025  ? 1401 A1ANM A N74  1 
HETATM 4866 N  N86  . A1ANM C 3 .   ? -6.75450  -29.67182 -2.71925  1.000 32.44908  ? 1401 A1ANM A N86  1 
HETATM 4867 O  O17  . A1ANM C 3 .   ? -11.51129 -23.95693 -8.47653  1.000 49.17560  ? 1401 A1ANM A O17  1 
HETATM 4868 O  O21  . A1ANM C 3 .   ? -8.91840  -25.00021 -9.62454  1.000 68.66634  ? 1401 A1ANM A O21  1 
HETATM 4869 O  O24  . A1ANM C 3 .   ? -7.68656  -25.76952 -12.43753 1.000 66.35051  ? 1401 A1ANM A O24  1 
HETATM 4870 O  O27  . A1ANM C 3 .   ? -6.16475  -27.48677 -14.24245 1.000 69.26489  ? 1401 A1ANM A O27  1 
HETATM 4871 O  O30  . A1ANM C 3 .   ? -4.30086  -27.86708 -16.45948 1.000 67.63713  ? 1401 A1ANM A O30  1 
HETATM 4872 O  O35  . A1ANM C 3 .   ? -6.28410  -29.08728 -20.75431 1.000 42.89665  ? 1401 A1ANM A O35  1 
HETATM 4873 O  O45  . A1ANM C 3 .   ? -8.40141  -29.36778 -28.98922 1.000 26.65911  ? 1401 A1ANM A O45  1 
HETATM 4874 O  O50  . A1ANM C 3 .   ? -10.65840 -28.06080 -31.32324 1.000 34.32425  ? 1401 A1ANM A O50  1 
HETATM 4875 O  O76  . A1ANM C 3 .   ? -8.13916  -25.00473 -2.82557  1.000 26.48140  ? 1401 A1ANM A O76  1 
HETATM 4876 O  O85  . A1ANM C 3 .   ? -4.62854  -30.39395 -2.39127  1.000 33.37452  ? 1401 A1ANM A O85  1 
HETATM 4877 CL CL55 . A1ANM C 3 .   ? -2.85728  -26.64732 -30.74063 1.000 29.77481  ? 1401 A1ANM A CL55 1 
HETATM 4878 CL CL65 . A1ANM C 3 .   ? -9.51963  -34.14541 -25.40380 1.000 42.22153  ? 1401 A1ANM A CL65 1 
HETATM 4879 O  O    . HOH   D 4 .   ? -5.99100  -16.87200 5.66500   1.000 38.40393  ? 1501 HOH   A O    1 
HETATM 4880 O  O    . HOH   D 4 .   ? 10.50700  -26.02200 11.94100  1.000 44.78231  ? 1502 HOH   A O    1 
HETATM 4881 O  O    . HOH   D 4 .   ? 2.68600   -16.07000 25.00400  1.000 42.22538  ? 1503 HOH   A O    1 
HETATM 4882 O  O    . HOH   D 4 .   ? -25.51700 -14.47300 -9.02300  1.000 59.36925  ? 1504 HOH   A O    1 
HETATM 4883 O  O    . HOH   D 4 .   ? -1.43000  -13.54500 -6.18500  1.000 48.25468  ? 1505 HOH   A O    1 
HETATM 4884 O  O    . HOH   D 4 .   ? -10.06700 -31.38100 -1.04200  1.000 39.27533  ? 1506 HOH   A O    1 
HETATM 4885 O  O    . HOH   D 4 .   ? -21.50200 -43.67400 5.87400   1.000 51.15530  ? 1507 HOH   A O    1 
HETATM 4886 O  O    . HOH   D 4 .   ? 9.08800   -19.40300 3.48600   1.000 33.83023  ? 1508 HOH   A O    1 
HETATM 4887 O  O    . HOH   D 4 .   ? -11.67500 -4.44900  17.60000  1.000 42.90482  ? 1509 HOH   A O    1 
HETATM 4888 O  O    . HOH   D 4 .   ? -14.59200 -1.51300  5.78700   1.000 46.51800  ? 1510 HOH   A O    1 
HETATM 4889 O  O    . HOH   D 4 .   ? 7.611     -8.018    20.531    1.000 45.60624  ? 1511 HOH   A O    1 
HETATM 4890 O  O    . HOH   D 4 .   ? -17.32300 -25.23500 21.78700  1.000 45.99943  ? 1512 HOH   A O    1 
HETATM 4891 O  O    . HOH   D 4 .   ? -6.20500  -12.55000 -7.11100  1.000 50.15904  ? 1513 HOH   A O    1 
HETATM 4892 O  O    . HOH   D 4 .   ? -28.28700 -22.11000 -4.04800  1.000 25.22486  ? 1514 HOH   A O    1 
HETATM 4893 O  O    . HOH   D 4 .   ? -23.22300 -20.72900 -9.85400  1.000 37.12888  ? 1515 HOH   A O    1 
HETATM 4894 O  O    . HOH   D 4 .   ? 5.849     -14.261   -5.005    1.000 33.97976  ? 1516 HOH   A O    1 
HETATM 4895 O  O    . HOH   D 4 .   ? 5.80800   -11.34100 21.67900  1.000 39.64278  ? 1517 HOH   A O    1 
HETATM 4896 O  O    . HOH   D 4 .   ? 9.80100   -14.71800 5.43000   1.000 40.38923  ? 1518 HOH   A O    1 
HETATM 4897 O  O    . HOH   D 4 .   ? 8.44400   -10.06800 11.32300  1.000 38.31593  ? 1519 HOH   A O    1 
HETATM 4898 O  O    . HOH   D 4 .   ? 11.37500  -28.75100 12.35400  1.000 41.11461  ? 1520 HOH   A O    1 
HETATM 4899 O  O    . HOH   D 4 .   ? -0.14900  -34.26700 -4.68400  1.000 41.72667  ? 1521 HOH   A O    1 
HETATM 4900 O  O    . HOH   D 4 .   ? -2.68000  -37.78700 21.73000  1.000 47.62385  ? 1522 HOH   A O    1 
HETATM 4901 O  O    . HOH   D 4 .   ? -2.68100  -22.95000 25.29400  1.000 42.13235  ? 1523 HOH   A O    1 
HETATM 4902 O  O    . HOH   D 4 .   ? -5.70800  -11.19600 19.88100  1.000 31.65367  ? 1524 HOH   A O    1 
HETATM 4903 O  O    . HOH   D 4 .   ? -1.50800  -18.25400 28.43300  1.000 43.41037  ? 1525 HOH   A O    1 
HETATM 4904 O  O    . HOH   D 4 .   ? -11.11500 -26.32200 12.55300  1.000 30.29752  ? 1526 HOH   A O    1 
HETATM 4905 O  O    . HOH   D 4 .   ? 0.38700   -41.95000 9.48500   1.000 36.22050  ? 1527 HOH   A O    1 
HETATM 4906 O  O    . HOH   D 4 .   ? -2.57500  -43.85200 9.55700   1.000 55.09824  ? 1528 HOH   A O    1 
HETATM 4907 O  O    . HOH   D 4 .   ? -7.21100  -23.36800 7.07200   1.000 25.68497  ? 1529 HOH   A O    1 
HETATM 4908 O  O    . HOH   D 4 .   ? 3.70800   -36.81400 -0.60800  1.000 43.49560  ? 1530 HOH   A O    1 
HETATM 4909 O  O    . HOH   D 4 .   ? -17.85300 -44.13300 5.87900   1.000 42.45380  ? 1531 HOH   A O    1 
HETATM 4910 O  O    . HOH   D 4 .   ? 0.06300   -43.75000 7.74700   1.000 54.79172  ? 1532 HOH   A O    1 
HETATM 4911 O  O    . HOH   D 4 .   ? 12.276    -27.100   21.314    1.000 33.69172  ? 1533 HOH   A O    1 
HETATM 4912 O  O    . HOH   D 4 .   ? -10.43100 -5.46700  -0.13800  1.000 35.66587  ? 1534 HOH   A O    1 
HETATM 4913 O  O    . HOH   D 4 .   ? -16.29500 -45.29000 8.26400   1.000 54.66119  ? 1535 HOH   A O    1 
HETATM 4914 O  O    . HOH   D 4 .   ? -24.18600 -15.12200 1.54900   1.000 33.45798  ? 1536 HOH   A O    1 
HETATM 4915 O  O    . HOH   D 4 .   ? -12.58100 1.66000   9.15200   1.000 46.80387  ? 1537 HOH   A O    1 
HETATM 4916 O  O    . HOH   D 4 .   ? 3.94800   -5.63600  10.28200  1.000 47.34575  ? 1538 HOH   A O    1 
HETATM 4917 O  O    . HOH   D 4 .   ? -12.46100 -19.61000 -7.31100  1.000 28.03766  ? 1539 HOH   A O    1 
HETATM 4918 O  O    . HOH   D 4 .   ? -4.41000  -16.04200 19.20000  1.000 27.07209  ? 1540 HOH   A O    1 
HETATM 4919 O  O    . HOH   D 4 .   ? 8.11100   -26.76600 2.63900   1.000 30.02933  ? 1541 HOH   A O    1 
HETATM 4920 O  O    . HOH   D 4 .   ? -13.17500 -42.67300 15.34500  1.000 43.47585  ? 1542 HOH   A O    1 
HETATM 4921 O  O    . HOH   D 4 .   ? 12.04200  -24.01200 14.65100  1.000 50.96931  ? 1543 HOH   A O    1 
HETATM 4922 O  O    . HOH   D 4 .   ? -12.30400 -26.18800 8.75700   1.000 33.74434  ? 1544 HOH   A O    1 
HETATM 4923 O  O    . HOH   D 4 .   ? -9.99100  -37.32000 25.93900  1.000 43.42831  ? 1545 HOH   A O    1 
HETATM 4924 O  O    . HOH   D 4 .   ? -26.86200 -14.18000 15.54300  1.000 54.70366  ? 1546 HOH   A O    1 
HETATM 4925 O  O    . HOH   D 4 .   ? -8.08500  0.21400   7.08500   1.000 42.23797  ? 1547 HOH   A O    1 
HETATM 4926 O  O    . HOH   D 4 .   ? 12.881    -23.901   17.376    1.000 51.00664  ? 1548 HOH   A O    1 
HETATM 4927 O  O    . HOH   D 4 .   ? 4.70700   -11.51800 1.51100   1.000 32.73001  ? 1549 HOH   A O    1 
HETATM 4928 O  O    . HOH   D 4 .   ? 8.56800   -36.65800 7.32300   1.000 45.80437  ? 1550 HOH   A O    1 
HETATM 4929 O  O    . HOH   D 4 .   ? -0.18900  -25.12800 25.28600  1.000 42.52314  ? 1551 HOH   A O    1 
HETATM 4930 O  O    . HOH   D 4 .   ? -13.03400 -21.92200 3.08000   1.000 21.94595  ? 1552 HOH   A O    1 
HETATM 4931 O  O    . HOH   D 4 .   ? -10.42100 -22.13100 13.54300  1.000 37.75988  ? 1553 HOH   A O    1 
HETATM 4932 O  O    . HOH   D 4 .   ? -16.51500 -40.80000 -0.82000  1.000 36.21528  ? 1554 HOH   A O    1 
HETATM 4933 O  O    . HOH   D 4 .   ? -7.57200  -30.16000 24.12500  1.000 38.63271  ? 1555 HOH   A O    1 
HETATM 4934 O  O    . HOH   D 4 .   ? 3.11500   -12.83500 4.28500   1.000 31.60328  ? 1556 HOH   A O    1 
HETATM 4935 O  O    . HOH   D 4 .   ? -22.59600 -17.07100 -6.64700  1.000 37.18585  ? 1557 HOH   A O    1 
HETATM 4936 O  O    . HOH   D 4 .   ? -24.45800 -33.76200 -3.63600  1.000 41.48724  ? 1558 HOH   A O    1 
HETATM 4937 O  O    . HOH   D 4 .   ? -5.29400  -24.24500 25.27000  1.000 40.65933  ? 1559 HOH   A O    1 
HETATM 4938 O  O    . HOH   D 4 .   ? -16.57300 -38.75300 1.68200   1.000 31.99239  ? 1560 HOH   A O    1 
HETATM 4939 O  O    . HOH   D 4 .   ? -35.842   -25.165   6.339     1.000 38.29471  ? 1561 HOH   A O    1 
HETATM 4940 O  O    . HOH   D 4 .   ? 5.55900   -12.01600 -1.81200  1.000 38.93851  ? 1562 HOH   A O    1 
HETATM 4941 O  O    . HOH   D 4 .   ? 4.60800   -28.07700 21.86600  1.000 43.93380  ? 1563 HOH   A O    1 
HETATM 4942 O  O    . HOH   D 4 .   ? 6.54700   -24.57400 -6.60600  1.000 30.84609  ? 1564 HOH   A O    1 
HETATM 4943 O  O    . HOH   D 4 .   ? 4.642     -23.975   -9.110    1.000 42.25245  ? 1565 HOH   A O    1 
HETATM 4944 O  O    . HOH   D 4 .   ? -12.47800 -34.42800 22.20100  1.000 44.60435  ? 1566 HOH   A O    1 
HETATM 4945 O  O    . HOH   D 4 .   ? -11.64400 -16.56800 1.25400   1.000 21.32462  ? 1567 HOH   A O    1 
HETATM 4946 O  O    . HOH   D 4 .   ? 8.43300   -29.28600 20.06200  1.000 46.48866  ? 1568 HOH   A O    1 
HETATM 4947 O  O    . HOH   D 4 .   ? -0.85600  -39.62500 2.11900   1.000 30.65452  ? 1569 HOH   A O    1 
HETATM 4948 O  O    . HOH   D 4 .   ? -3.53800  -46.03900 9.30000   1.000 44.19716  ? 1570 HOH   A O    1 
HETATM 4949 O  O    . HOH   D 4 .   ? -29.74000 -8.97600  -2.98200  1.000 40.65759  ? 1571 HOH   A O    1 
HETATM 4950 O  O    . HOH   D 4 .   ? 12.84200  -22.33700 7.63800   1.000 30.82558  ? 1572 HOH   A O    1 
HETATM 4951 O  O    . HOH   D 4 .   ? -22.54700 -13.72100 -1.61700  1.000 30.52610  ? 1573 HOH   A O    1 
HETATM 4952 O  O    . HOH   D 4 .   ? -14.89200 -22.74700 8.86000   1.000 29.79175  ? 1574 HOH   A O    1 
HETATM 4953 O  O    . HOH   D 4 .   ? -30.130   -12.401   4.138     1.000 33.67005  ? 1575 HOH   A O    1 
HETATM 4954 O  O    . HOH   D 4 .   ? -20.73000 -35.60200 -7.90300  1.000 40.32753  ? 1576 HOH   A O    1 
HETATM 4955 O  O    . HOH   D 4 .   ? -9.63000  -34.34700 -10.66300 1.000 51.85396  ? 1577 HOH   A O    1 
HETATM 4956 O  O    . HOH   D 4 .   ? -20.13600 -22.64600 -9.56700  1.000 43.54559  ? 1578 HOH   A O    1 
HETATM 4957 O  O    . HOH   D 4 .   ? -7.00200  -22.34600 10.01100  1.000 26.08342  ? 1579 HOH   A O    1 
HETATM 4958 O  O    . HOH   D 4 .   ? -14.54600 -1.10700  3.46100   1.000 43.83317  ? 1580 HOH   A O    1 
HETATM 4959 O  O    . HOH   D 4 .   ? -15.11500 -5.61300  -4.55700  1.000 45.41100  ? 1581 HOH   A O    1 
HETATM 4960 O  O    . HOH   D 4 .   ? -3.24100  -10.54400 18.97300  1.000 36.17046  ? 1582 HOH   A O    1 
HETATM 4961 O  O    . HOH   D 4 .   ? -3.96300  -14.47800 17.12300  1.000 33.70641  ? 1583 HOH   A O    1 
HETATM 4962 O  O    . HOH   D 4 .   ? -21.73500 -42.97200 3.21400   1.000 45.67207  ? 1584 HOH   A O    1 
HETATM 4963 O  O    . HOH   D 4 .   ? -6.98300  -22.09200 17.45600  1.000 42.28461  ? 1585 HOH   A O    1 
HETATM 4964 O  O    . HOH   D 4 .   ? -10.35700 -21.86300 3.53800   1.000 24.00035  ? 1586 HOH   A O    1 
HETATM 4965 O  O    . HOH   D 4 .   ? 2.185     -17.539   28.202    1.000 45.82095  ? 1587 HOH   A O    1 
HETATM 4966 O  O    . HOH   D 4 .   ? -12.91600 -29.34800 14.64000  1.000 33.40792  ? 1588 HOH   A O    1 
HETATM 4967 O  O    . HOH   D 4 .   ? -9.84600  -30.30700 -19.93900 1.000 43.62371  ? 1589 HOH   A O    1 
HETATM 4968 O  O    . HOH   D 4 .   ? -2.79600  -38.27000 4.34600   1.000 34.50105  ? 1590 HOH   A O    1 
HETATM 4969 O  O    . HOH   D 4 .   ? -11.79100 -2.41600  5.87800   1.000 38.12223  ? 1591 HOH   A O    1 
HETATM 4970 O  O    . HOH   D 4 .   ? -29.64300 -25.81100 -2.18300  1.000 37.84416  ? 1592 HOH   A O    1 
HETATM 4971 O  O    . HOH   D 4 .   ? -9.21600  -22.42900 -2.87300  1.000 23.97393  ? 1593 HOH   A O    1 
HETATM 4972 O  O    . HOH   D 4 .   ? -24.55100 -20.04800 18.37000  1.000 50.17219  ? 1594 HOH   A O    1 
HETATM 4973 O  O    . HOH   D 4 .   ? 5.85600   -34.09500 1.21600   1.000 41.37947  ? 1595 HOH   A O    1 
HETATM 4974 O  O    . HOH   D 4 .   ? -11.67900 -12.58700 2.37800   1.000 38.64275  ? 1596 HOH   A O    1 
HETATM 4975 O  O    . HOH   D 4 .   ? -26.02200 -22.11400 -8.30900  1.000 32.39395  ? 1597 HOH   A O    1 
HETATM 4976 O  O    . HOH   D 4 .   ? 5.992     -27.432   -6.786    1.000 38.65312  ? 1598 HOH   A O    1 
HETATM 4977 O  O    . HOH   D 4 .   ? -9.34400  -24.78700 -34.28600 1.000 30.45144  ? 1599 HOH   A O    1 
HETATM 4978 O  O    . HOH   D 4 .   ? -22.16400 -9.27500  -1.95600  1.000 52.96302  ? 1600 HOH   A O    1 
HETATM 4979 O  O    . HOH   D 4 .   ? -7.91400  -25.77500 15.56500  1.000 35.38211  ? 1601 HOH   A O    1 
HETATM 4980 O  O    . HOH   D 4 .   ? -20.21500 -28.99900 -8.29400  1.000 29.17276  ? 1602 HOH   A O    1 
HETATM 4981 O  O    . HOH   D 4 .   ? -13.83000 -26.71300 -33.41800 1.000 40.00242  ? 1603 HOH   A O    1 
HETATM 4982 O  O    . HOH   D 4 .   ? -18.36500 -11.28800 2.77300   1.000 31.13768  ? 1604 HOH   A O    1 
HETATM 4983 O  O    . HOH   D 4 .   ? -14.35800 2.84800   11.82800  1.000 48.74341  ? 1605 HOH   A O    1 
HETATM 4984 O  O    . HOH   D 4 .   ? -9.24400  -27.56100 14.23500  1.000 25.66560  ? 1606 HOH   A O    1 
HETATM 4985 O  O    . HOH   D 4 .   ? -3.83500  -38.97800 20.06600  1.000 43.05876  ? 1607 HOH   A O    1 
HETATM 4986 O  O    . HOH   D 4 .   ? 0.85500   -14.97100 -5.42000  1.000 40.40348  ? 1608 HOH   A O    1 
HETATM 4987 O  O    . HOH   D 4 .   ? -17.11500 -13.75900 19.74800  1.000 50.47309  ? 1609 HOH   A O    1 
HETATM 4988 O  O    . HOH   D 4 .   ? -10.70200 -14.87400 4.18900   1.000 31.47517  ? 1610 HOH   A O    1 
HETATM 4989 O  O    . HOH   D 4 .   ? 6.72300   -9.90200  18.98000  1.000 47.36912  ? 1611 HOH   A O    1 
HETATM 4990 O  O    . HOH   D 4 .   ? -9.67000  -46.69700 7.01400   1.000 37.56186  ? 1612 HOH   A O    1 
HETATM 4991 O  O    . HOH   D 4 .   ? 6.58700   -39.11900 11.12900  1.000 39.86163  ? 1613 HOH   A O    1 
HETATM 4992 O  O    . HOH   D 4 .   ? -11.58700 -17.82000 14.75800  1.000 31.19177  ? 1614 HOH   A O    1 
HETATM 4993 O  O    . HOH   D 4 .   ? -10.52700 -21.46600 -5.06800  1.000 37.27934  ? 1615 HOH   A O    1 
HETATM 4994 O  O    . HOH   D 4 .   ? -31.72500 -31.33100 5.10800   1.000 39.72629  ? 1616 HOH   A O    1 
HETATM 4995 O  O    . HOH   D 4 .   ? -8.89700  -24.33600 23.29200  1.000 39.00436  ? 1617 HOH   A O    1 
HETATM 4996 O  O    . HOH   D 4 .   ? -35.60200 -20.33900 10.81700  1.000 43.18436  ? 1618 HOH   A O    1 
HETATM 4997 O  O    . HOH   D 4 .   ? -9.51100  -18.17700 16.59500  1.000 40.22847  ? 1619 HOH   A O    1 
HETATM 4998 O  O    . HOH   D 4 .   ? -16.95700 -4.74700  -1.05000  1.000 48.35925  ? 1620 HOH   A O    1 
HETATM 4999 O  O    . HOH   D 4 .   ? -7.72600  -19.86000 14.72800  1.000 32.43677  ? 1621 HOH   A O    1 
HETATM 5000 O  O    . HOH   D 4 .   ? -19.10100 -20.57100 18.07600  1.000 39.65411  ? 1622 HOH   A O    1 
HETATM 5001 O  O    . HOH   D 4 .   ? 5.92500   -26.80100 4.90500   1.000 28.22840  ? 1623 HOH   A O    1 
HETATM 5002 O  O    . HOH   D 4 .   ? -6.88700  3.35700   21.69600  1.000 78.44517  ? 1624 HOH   A O    1 
HETATM 5003 O  O    . HOH   D 4 .   ? -30.01900 -35.39000 0.93500   1.000 46.57076  ? 1625 HOH   A O    1 
HETATM 5004 O  O    . HOH   D 4 .   ? -13.77700 -23.58900 11.35900  1.000 38.66266  ? 1626 HOH   A O    1 
HETATM 5005 O  O    . HOH   D 4 .   ? -11.69600 -10.94600 17.40600  1.000 33.37816  ? 1627 HOH   A O    1 
HETATM 5006 O  O    . HOH   D 4 .   ? -10.85000 -37.07800 -7.18100  1.000 39.08542  ? 1628 HOH   A O    1 
HETATM 5007 O  O    . HOH   D 4 .   ? -14.26500 -28.33700 16.79600  1.000 49.58152  ? 1629 HOH   A O    1 
HETATM 5008 O  O    . HOH   D 4 .   ? 1.90400   -3.52300  8.81200   1.000 39.65174  ? 1630 HOH   A O    1 
HETATM 5009 O  O    . HOH   D 4 .   ? -6.42500  -23.17800 14.77400  1.000 27.88636  ? 1631 HOH   A O    1 
HETATM 5010 O  O    . HOH   D 4 .   ? -7.33800  -15.99900 19.42100  1.000 30.70713  ? 1632 HOH   A O    1 
HETATM 5011 O  O    . HOH   D 4 .   ? -29.33100 -29.15100 16.68800  1.000 42.03843  ? 1633 HOH   A O    1 
HETATM 5012 O  O    . HOH   D 4 .   ? -10.29000 -0.94400  1.16500   1.000 44.13715  ? 1634 HOH   A O    1 
HETATM 5013 O  O    . HOH   D 4 .   ? -16.68000 -27.00600 14.20100  1.000 35.26146  ? 1635 HOH   A O    1 
HETATM 5014 O  O    . HOH   D 4 .   ? -27.73500 -19.45700 -4.97200  1.000 31.58118  ? 1636 HOH   A O    1 
HETATM 5015 O  O    . HOH   D 4 .   ? -21.23800 -19.15800 -8.68700  1.000 42.31072  ? 1637 HOH   A O    1 
HETATM 5016 O  O    . HOH   D 4 .   ? -23.73200 -45.00900 12.94100  1.000 45.84393  ? 1638 HOH   A O    1 
HETATM 5017 O  O    . HOH   D 4 .   ? -26.66500 -30.09800 -5.45100  1.000 36.59487  ? 1639 HOH   A O    1 
HETATM 5018 O  O    . HOH   D 4 .   ? 5.99500   -33.43400 -4.26800  1.000 49.94909  ? 1640 HOH   A O    1 
HETATM 5019 O  O    . HOH   D 4 .   ? -11.44700 -27.97100 23.52600  1.000 45.24248  ? 1641 HOH   A O    1 
HETATM 5020 O  O    . HOH   D 4 .   ? 0.88700   -13.86300 24.07000  1.000 41.53453  ? 1642 HOH   A O    1 
HETATM 5021 O  O    . HOH   D 4 .   ? 11.278    -11.346   14.834    1.000 42.85481  ? 1643 HOH   A O    1 
HETATM 5022 O  O    . HOH   D 4 .   ? -19.99600 -9.53000  -0.34200  1.000 44.61452  ? 1644 HOH   A O    1 
HETATM 5023 O  O    . HOH   D 4 .   ? -12.90800 -36.07800 -9.10700  1.000 48.29463  ? 1645 HOH   A O    1 
HETATM 5024 O  O    . HOH   D 4 .   ? -7.95500  -19.42500 18.64500  1.000 45.76757  ? 1646 HOH   A O    1 
HETATM 5025 O  O    . HOH   D 4 .   ? -20.85700 -11.91000 3.31400   1.000 33.16224  ? 1647 HOH   A O    1 
HETATM 5026 O  O    . HOH   D 4 .   ? 13.310    -19.534   13.147    1.000 41.44743  ? 1648 HOH   A O    1 
HETATM 5027 O  O    . HOH   D 4 .   ? -12.81500 -41.90800 17.83200  1.000 40.13843  ? 1649 HOH   A O    1 
HETATM 5028 O  O    . HOH   D 4 .   ? 8.523     -12.391   20.265    1.000 51.45338  ? 1650 HOH   A O    1 
HETATM 5029 O  O    . HOH   D 4 .   ? -27.54300 -6.94800  6.20500   1.000 53.02097  ? 1651 HOH   A O    1 
HETATM 5030 O  O    . HOH   D 4 .   ? 12.68500  -20.76100 11.09400  1.000 43.12087  ? 1652 HOH   A O    1 
HETATM 5031 O  O    . HOH   D 4 .   ? -5.39700  -44.61100 5.46200   1.000 37.04650  ? 1653 HOH   A O    1 
HETATM 5032 O  O    . HOH   D 4 .   ? 0.79800   -21.48200 26.96500  1.000 59.57404  ? 1654 HOH   A O    1 
HETATM 5033 O  O    . HOH   D 4 .   ? -14.35200 -25.12600 7.14700   1.000 26.34630  ? 1655 HOH   A O    1 
HETATM 5034 O  O    . HOH   D 4 .   ? 5.74800   -7.85000  8.32000   1.000 41.00926  ? 1656 HOH   A O    1 
HETATM 5035 O  O    . HOH   D 4 .   ? -18.72700 -47.06600 8.53400   1.000 60.36531  ? 1657 HOH   A O    1 
HETATM 5036 O  O    . HOH   D 4 .   ? 3.18000   -43.63800 18.77900  1.000 55.68392  ? 1658 HOH   A O    1 
HETATM 5037 O  O    . HOH   D 4 .   ? -17.61800 -22.60000 17.39900  1.000 40.46992  ? 1659 HOH   A O    1 
HETATM 5038 O  O    . HOH   D 4 .   ? -14.90100 -34.29300 23.50500  1.000 56.90952  ? 1660 HOH   A O    1 
HETATM 5039 O  O    . HOH   D 4 .   ? 5.77400   -35.47900 -0.40200  1.000 49.22180  ? 1661 HOH   A O    1 
HETATM 5040 O  O    . HOH   D 4 .   ? -29.71000 -37.61400 5.06500   1.000 45.06438  ? 1662 HOH   A O    1 
HETATM 5041 O  O    . HOH   D 4 .   ? -8.06200  -27.42300 -16.57200 1.000 52.03852  ? 1663 HOH   A O    1 
HETATM 5042 O  O    . HOH   D 4 .   ? -23.47900 -40.89800 2.47200   1.000 50.78158  ? 1664 HOH   A O    1 
HETATM 5043 O  O    . HOH   D 4 .   ? 7.76600   -30.84100 18.09700  1.000 40.24172  ? 1665 HOH   A O    1 
HETATM 5044 O  O    . HOH   D 4 .   ? 11.98400  -17.48600 9.93700   1.000 36.00845  ? 1666 HOH   A O    1 
HETATM 5045 O  O    . HOH   D 4 .   ? -23.84100 -32.83600 -7.14200  1.000 44.23056  ? 1667 HOH   A O    1 
HETATM 5046 O  O    . HOH   D 4 .   ? -9.56200  -0.92400  4.76100   1.000 46.77170  ? 1668 HOH   A O    1 
HETATM 5047 O  O    . HOH   D 4 .   ? -24.73300 -17.99700 -8.13700  1.000 49.05289  ? 1669 HOH   A O    1 
HETATM 5048 O  O    . HOH   D 4 .   ? -14.30900 -6.36300  19.85400  1.000 49.67833  ? 1670 HOH   A O    1 
HETATM 5049 O  O    . HOH   D 4 .   ? -12.70500 -29.89700 -32.62100 1.000 49.23718  ? 1671 HOH   A O    1 
HETATM 5050 O  O    . HOH   D 4 .   ? -0.86100  -23.61200 -5.48700  1.000 40.09256  ? 1672 HOH   A O    1 
HETATM 5051 O  O    . HOH   D 4 .   ? -7.68200  -44.16700 1.38200   1.000 53.28717  ? 1673 HOH   A O    1 
HETATM 5052 O  O    . HOH   D 4 .   ? 0.56800   -44.52600 4.67000   1.000 50.57604  ? 1674 HOH   A O    1 
HETATM 5053 O  O    . HOH   D 4 .   ? 6.30600   -26.26700 20.93500  1.000 37.46825  ? 1675 HOH   A O    1 
HETATM 5054 O  O    . HOH   D 4 .   ? -12.41500 -28.76300 18.27300  1.000 44.99523  ? 1676 HOH   A O    1 
HETATM 5055 O  O    . HOH   D 4 .   ? -19.38200 -33.43700 -8.51800  1.000 42.66850  ? 1677 HOH   A O    1 
HETATM 5056 O  O    . HOH   D 4 .   ? 3.46500   -42.01100 15.43300  1.000 53.15721  ? 1678 HOH   A O    1 
HETATM 5057 O  O    . HOH   D 4 .   ? -26.62600 -30.39800 -2.88100  1.000 35.77841  ? 1679 HOH   A O    1 
HETATM 5058 O  O    . HOH   D 4 .   ? 5.75400   -19.55300 18.00000  1.000 40.25430  ? 1680 HOH   A O    1 
HETATM 5059 O  O    . HOH   D 4 .   ? 11.47700  -26.37200 9.18000   1.000 40.99710  ? 1681 HOH   A O    1 
HETATM 5060 O  O    . HOH   D 4 .   ? -17.88100 -38.01000 22.03300  1.000 41.64320  ? 1682 HOH   A O    1 
HETATM 5061 O  O    . HOH   D 4 .   ? -19.96600 -0.37200  11.05400  1.000 61.79691  ? 1683 HOH   A O    1 
HETATM 5062 O  O    . HOH   D 4 .   ? -33.94600 -30.32600 16.45500  1.000 45.76060  ? 1684 HOH   A O    1 
HETATM 5063 O  O    . HOH   D 4 .   ? 7.38000   -35.10200 3.45400   1.000 49.68478  ? 1685 HOH   A O    1 
HETATM 5064 O  O    . HOH   D 4 .   ? -29.19200 -42.23800 8.86500   1.000 55.15607  ? 1686 HOH   A O    1 
HETATM 5065 O  O    . HOH   D 4 .   ? -13.10900 -47.00700 8.08000   1.000 44.51738  ? 1687 HOH   A O    1 
HETATM 5066 O  O    . HOH   D 4 .   ? -8.56200  -29.51200 -14.24200 1.000 64.78684  ? 1688 HOH   A O    1 
HETATM 5067 O  O    . HOH   D 4 .   ? -14.41700 -33.28500 -11.04800 1.000 45.49364  ? 1689 HOH   A O    1 
HETATM 5068 O  O    . HOH   D 4 .   ? -7.24700  -23.97000 18.80600  1.000 39.89093  ? 1690 HOH   A O    1 
HETATM 5069 O  O    . HOH   D 4 .   ? -8.08400  -21.91000 12.52000  1.000 33.59841  ? 1691 HOH   A O    1 
HETATM 5070 O  O    . HOH   D 4 .   ? -26.77800 -35.32700 13.52100  1.000 48.89431  ? 1692 HOH   A O    1 
HETATM 5071 O  O    . HOH   D 4 .   ? -10.73600 -42.72900 19.30300  1.000 54.09141  ? 1693 HOH   A O    1 
HETATM 5072 O  O    . HOH   D 4 .   ? -29.05100 -28.97400 -3.50300  1.000 36.56344  ? 1694 HOH   A O    1 
HETATM 5073 O  O    . HOH   D 4 .   ? 8.37300   -30.24200 -6.20500  1.000 48.23786  ? 1695 HOH   A O    1 
HETATM 5074 O  O    . HOH   D 4 .   ? -27.70800 -17.29500 18.49500  1.000 63.57177  ? 1696 HOH   A O    1 
HETATM 5075 O  O    . HOH   D 4 .   ? -4.45700  -32.98800 25.64600  1.000 52.12076  ? 1697 HOH   A O    1 
HETATM 5076 O  O    . HOH   D 4 .   ? -19.49800 -1.99400  7.60500   1.000 42.61183  ? 1698 HOH   A O    1 
HETATM 5077 O  O    . HOH   D 4 .   ? -31.22600 -33.82800 4.78300   1.000 45.21131  ? 1699 HOH   A O    1 
HETATM 5078 O  O    . HOH   D 4 .   ? -19.52700 -8.55600  -5.70400  1.000 45.02275  ? 1700 HOH   A O    1 
HETATM 5079 O  O    . HOH   D 4 .   ? 5.74500   -31.17100 -6.19000  1.000 48.83991  ? 1701 HOH   A O    1 
HETATM 5080 O  O    . HOH   D 4 .   ? -7.59500  -36.31300 26.85500  1.000 49.15783  ? 1702 HOH   A O    1 
HETATM 5081 O  O    . HOH   D 4 .   ? -3.33600  -44.54900 6.83700   1.000 45.48422  ? 1703 HOH   A O    1 
HETATM 5082 O  O    . HOH   D 4 .   ? -7.99300  -42.95700 19.55200  1.000 49.61818  ? 1704 HOH   A O    1 
HETATM 5083 O  O    . HOH   D 4 .   ? -12.21100 -36.77600 20.51100  1.000 47.66788  ? 1705 HOH   A O    1 
HETATM 5084 O  O    . HOH   D 4 .   ? -8.52200  -23.55600 -14.88500 1.000 49.13809  ? 1706 HOH   A O    1 
HETATM 5085 O  O    . HOH   D 4 .   ? 11.35000  -23.94300 12.35100  1.000 50.73688  ? 1707 HOH   A O    1 
HETATM 5086 O  O    . HOH   D 4 .   ? -19.59300 -6.40500  17.45000  1.000 52.04694  ? 1708 HOH   A O    1 
HETATM 5087 O  O    . HOH   D 4 .   ? -22.03500 -13.80900 -9.01800  1.000 55.62219  ? 1709 HOH   A O    1 
HETATM 5088 O  O    . HOH   D 4 .   ? 6.50900   -8.06200  10.35200  1.000 49.68220  ? 1710 HOH   A O    1 
HETATM 5089 O  O    . HOH   D 4 .   ? 10.14700  -10.50900 4.48000   1.000 46.70451  ? 1711 HOH   A O    1 
HETATM 5090 O  O    . HOH   D 4 .   ? -3.83200  -7.12700  24.57600  1.000 43.58991  ? 1712 HOH   A O    1 
HETATM 5091 O  O    . HOH   D 4 .   ? 1.99400   -22.79200 -9.37900  1.000 54.26010  ? 1713 HOH   A O    1 
HETATM 5092 O  O    . HOH   D 4 .   ? -20.87700 -25.34400 25.11500  1.000 58.49949  ? 1714 HOH   A O    1 
HETATM 5093 O  O    . HOH   D 4 .   ? -18.31600 -34.35200 -11.78900 1.000 44.10830  ? 1715 HOH   A O    1 
HETATM 5094 O  O    . HOH   D 4 .   ? -22.55200 -11.68200 -8.24500  1.000 48.94656  ? 1716 HOH   A O    1 
HETATM 5095 O  O    . HOH   D 4 .   ? 3.71900   -18.35200 24.25000  1.000 46.07207  ? 1717 HOH   A O    1 
HETATM 5096 O  O    . HOH   D 4 .   ? -7.82700  -27.73100 25.99900  1.000 49.03140  ? 1718 HOH   A O    1 
HETATM 5097 O  O    . HOH   D 4 .   ? -22.47000 -12.80900 1.66200   1.000 49.26972  ? 1719 HOH   A O    1 
HETATM 5098 O  O    . HOH   D 4 .   ? -27.99800 -9.86200  -6.80200  1.000 61.83149  ? 1720 HOH   A O    1 
HETATM 5099 O  O    . HOH   D 4 .   ? -28.46200 -28.57200 -6.80900  1.000 37.07100  ? 1721 HOH   A O    1 
HETATM 5100 O  O    . HOH   D 4 .   ? -20.56300 -27.46400 24.90100  1.000 56.35548  ? 1722 HOH   A O    1 
HETATM 5101 O  O    . HOH   D 4 .   ? -22.13400 -14.09400 3.19800   1.000 47.94590  ? 1723 HOH   A O    1 
HETATM 5102 O  O    . HOH   D 4 .   ? -8.17700  -0.38200  2.86400   1.000 48.70487  ? 1724 HOH   A O    1 
HETATM 5103 O  O    . HOH   D 4 .   ? -7.97000  -6.83200  -6.66300  1.000 64.27365  ? 1725 HOH   A O    1 
HETATM 5104 O  O    . HOH   D 4 .   ? -1.22300  -23.86300 27.45500  1.000 49.94952  ? 1726 HOH   A O    1 
HETATM 5105 O  O    . HOH   D 4 .   ? -18.00500 -8.62100  19.46300  1.000 57.65345  ? 1727 HOH   A O    1 
HETATM 5106 O  O    . HOH   D 4 .   ? 13.713    -26.057   19.443    1.000 35.17166  ? 1728 HOH   A O    1 
HETATM 5107 O  O    . HOH   D 4 .   ? -9.47000  -4.40600  -5.97900  1.000 53.53659  ? 1729 HOH   A O    1 
HETATM 5108 O  O    . HOH   D 4 .   ? -15.45900 -8.57600  19.87600  1.000 56.42114  ? 1730 HOH   A O    1 
HETATM 5109 O  O    . HOH   D 4 .   ? -6.68000  -23.85300 -21.22900 1.000 32.58243  ? 1731 HOH   A O    1 
HETATM 5110 O  O    . HOH   D 4 .   ? -10.10500 -26.29300 24.94800  1.000 54.22987  ? 1732 HOH   A O    1 
HETATM 5111 O  O    . HOH   D 4 .   ? -10.92800 -23.96300 13.08800  1.000 49.08169  ? 1733 HOH   A O    1 
HETATM 5112 O  O    . HOH   D 4 .   ? -13.62600 1.48800   2.87400   1.000 60.81061  ? 1734 HOH   A O    1 
HETATM 5113 O  O    . HOH   D 4 .   ? -16.91200 -11.77100 18.48800  1.000 48.89396  ? 1735 HOH   A O    1 
HETATM 5114 O  O    . HOH   D 4 .   ? 9.386     -9.281    21.076    1.000 44.60862  ? 1736 HOH   A O    1 
HETATM 5115 O  O    . HOH   D 4 .   ? 1.39400   -40.12800 0.95900   1.000 39.77768  ? 1737 HOH   A O    1 
HETATM 5116 O  O    . HOH   D 4 .   ? 7.36100   -12.51400 -3.43000  1.000 35.79987  ? 1738 HOH   A O    1 
HETATM 5117 O  O    . HOH   D 4 .   ? -24.077   -27.421   25.368    1.000 53.09959  ? 1739 HOH   A O    1 
HETATM 5118 O  O    . HOH   D 4 .   ? -18.56500 -28.30100 24.44500  1.000 53.12670  ? 1740 HOH   A O    1 
HETATM 5119 O  O    . HOH   D 4 .   ? -0.87700  4.45500   9.98100   1.000 54.57932  ? 1741 HOH   A O    1 
HETATM 5120 O  O    . HOH   D 4 .   ? -26.46400 -32.38700 -6.93100  1.000 44.69420  ? 1742 HOH   A O    1 
HETATM 5121 O  O    . HOH   D 4 .   ? -14.10700 -18.02500 -8.96000  1.000 34.60831  ? 1743 HOH   A O    1 
HETATM 5122 O  O    . HOH   D 4 .   ? 3.21500   -4.19200  3.07500   1.000 49.74198  ? 1744 HOH   A O    1 
HETATM 5123 O  O    . HOH   D 4 .   ? -9.19300  -36.25600 -8.93800  1.000 48.68659  ? 1745 HOH   A O    1 
HETATM 5124 O  O    . HOH   D 4 .   ? -9.32400  -24.10500 20.29000  1.000 43.68207  ? 1746 HOH   A O    1 
HETATM 5125 O  O    . HOH   D 4 .   ? -19.648   -48.201   17.397    1.000 47.06081  ? 1747 HOH   A O    1 
HETATM 5126 O  O    . HOH   D 4 .   ? -9.98000  -29.17600 -17.40200 1.000 44.72576  ? 1748 HOH   A O    1 
HETATM 5127 O  O    . HOH   D 4 .   ? 14.822    -22.661   16.642    1.000 40.05566  ? 1749 HOH   A O    1 
HETATM 5128 O  O    . HOH   D 4 .   ? -14.06500 -11.00900 19.10100  1.000 46.81063  ? 1750 HOH   A O    1 
HETATM 5129 O  O    . HOH   D 4 .   ? -12.15700 3.38300   4.07400   1.000 64.52082  ? 1751 HOH   A O    1 
HETATM 5130 O  O    . HOH   D 4 .   ? 5.04100   1.25300   -3.22700  1.000 59.45249  ? 1752 HOH   A O    1 
HETATM 5131 O  O    . HOH   E 4 .   ? -6.20800  -26.10700 -9.81800  1.000 63.01395  ? 1401 HOH   B O    1 
HETATM 5132 O  O    . HOH   E 4 .   ? -28.74500 -13.38900 -29.53900 1.000 46.90474  ? 1402 HOH   B O    1 
HETATM 5133 O  O    . HOH   E 4 .   ? -2.99200  -8.58900  -20.71900 1.000 45.83267  ? 1403 HOH   B O    1 
HETATM 5134 O  O    . HOH   E 4 .   ? -4.85300  -24.96500 -19.49200 1.000 42.92969  ? 1404 HOH   B O    1 
HETATM 5135 O  O    . HOH   E 4 .   ? -9.26700  -51.11900 -45.51100 1.000 42.22011  ? 1405 HOH   B O    1 
HETATM 5136 O  O    . HOH   E 4 .   ? -28.06500 -34.70600 -20.55200 1.000 44.99051  ? 1406 HOH   B O    1 
HETATM 5137 O  O    . HOH   E 4 .   ? -8.12400  -24.92800 -46.97000 1.000 49.25575  ? 1407 HOH   B O    1 
HETATM 5138 O  O    . HOH   E 4 .   ? 0.06400   -15.18800 -14.03000 1.000 57.41793  ? 1408 HOH   B O    1 
HETATM 5139 O  O    . HOH   E 4 .   ? -32.48300 -14.03900 -27.58400 1.000 64.34696  ? 1409 HOH   B O    1 
HETATM 5140 O  O    . HOH   E 4 .   ? -31.44600 -21.13700 -32.61100 1.000 58.32578  ? 1410 HOH   B O    1 
HETATM 5141 O  O    . HOH   E 4 .   ? -10.44800 -46.96400 -29.48900 1.000 28.57870  ? 1411 HOH   B O    1 
HETATM 5142 O  O    . HOH   E 4 .   ? -19.68800 -38.88000 -44.05700 1.000 40.58231  ? 1412 HOH   B O    1 
HETATM 5143 O  O    . HOH   E 4 .   ? -28.60200 -39.17800 -20.33300 1.000 37.58694  ? 1413 HOH   B O    1 
HETATM 5144 O  O    . HOH   E 4 .   ? -27.63200 -24.64000 -16.81000 1.000 41.19841  ? 1414 HOH   B O    1 
HETATM 5145 O  O    . HOH   E 4 .   ? -4.45500  -24.27200 -43.25700 1.000 36.09581  ? 1415 HOH   B O    1 
HETATM 5146 O  O    . HOH   E 4 .   ? -6.64700  -52.93600 -45.33900 1.000 49.96025  ? 1416 HOH   B O    1 
HETATM 5147 O  O    . HOH   E 4 .   ? -2.78800  -45.51100 -29.81400 1.000 28.59262  ? 1417 HOH   B O    1 
HETATM 5148 O  O    . HOH   E 4 .   ? 0.21300   -45.89300 -30.06300 1.000 33.09196  ? 1418 HOH   B O    1 
HETATM 5149 O  O    . HOH   E 4 .   ? -6.43300  -45.94600 -28.48300 1.000 27.19233  ? 1419 HOH   B O    1 
HETATM 5150 O  O    . HOH   E 4 .   ? -11.42300 -27.27900 -7.41100  1.000 50.97976  ? 1420 HOH   B O    1 
HETATM 5151 O  O    . HOH   E 4 .   ? -34.97200 -44.34200 -39.88400 1.000 65.44313  ? 1421 HOH   B O    1 
HETATM 5152 O  O    . HOH   E 4 .   ? -35.46900 -20.39300 -31.27200 1.000 66.30363  ? 1422 HOH   B O    1 
HETATM 5153 O  O    . HOH   E 4 .   ? -22.61500 -20.84300 -13.10900 1.000 45.65069  ? 1423 HOH   B O    1 
HETATM 5154 O  O    . HOH   E 4 .   ? -16.26000 -27.80300 -26.17500 1.000 34.17150  ? 1424 HOH   B O    1 
HETATM 5155 O  O    . HOH   E 4 .   ? -8.00900  -53.69800 -33.21400 1.000 46.97879  ? 1425 HOH   B O    1 
HETATM 5156 O  O    . HOH   E 4 .   ? -33.52300 -20.51000 -25.59800 1.000 42.98239  ? 1426 HOH   B O    1 
HETATM 5157 O  O    . HOH   E 4 .   ? -13.23200 -33.97600 -31.17200 1.000 28.35570  ? 1427 HOH   B O    1 
HETATM 5158 O  O    . HOH   E 4 .   ? -8.74600  -25.25700 -39.37100 1.000 40.23883  ? 1428 HOH   B O    1 
HETATM 5159 O  O    . HOH   E 4 .   ? -1.50700  -37.05800 -22.88800 1.000 40.38940  ? 1429 HOH   B O    1 
HETATM 5160 O  O    . HOH   E 4 .   ? 0.902     -6.520    -29.715   1.000 30.45129  ? 1430 HOH   B O    1 
HETATM 5161 O  O    . HOH   E 4 .   ? 2.54400   -36.92300 -49.94500 1.000 55.83762  ? 1431 HOH   B O    1 
HETATM 5162 O  O    . HOH   E 4 .   ? -31.170   -15.987   -22.743   1.000 45.41006  ? 1432 HOH   B O    1 
HETATM 5163 O  O    . HOH   E 4 .   ? -15.98600 -33.21800 -44.66700 1.000 40.71178  ? 1433 HOH   B O    1 
HETATM 5164 O  O    . HOH   E 4 .   ? -14.81400 -52.58900 -23.24800 1.000 46.57257  ? 1434 HOH   B O    1 
HETATM 5165 O  O    . HOH   E 4 .   ? -11.22700 -8.19700  -18.89000 1.000 55.13137  ? 1435 HOH   B O    1 
HETATM 5166 O  O    . HOH   E 4 .   ? -19.55700 -45.13200 -26.68700 1.000 31.16212  ? 1436 HOH   B O    1 
HETATM 5167 O  O    . HOH   E 4 .   ? -16.62700 -26.23500 -27.62800 1.000 32.94374  ? 1437 HOH   B O    1 
HETATM 5168 O  O    . HOH   E 4 .   ? 5.449     -13.384   -29.016   1.000 40.91619  ? 1438 HOH   B O    1 
HETATM 5169 O  O    . HOH   E 4 .   ? -8.77500  -1.86800  -34.76600 1.000 41.28237  ? 1439 HOH   B O    1 
HETATM 5170 O  O    . HOH   E 4 .   ? -10.85800 -29.80300 -38.82100 1.000 41.95632  ? 1440 HOH   B O    1 
HETATM 5171 O  O    . HOH   E 4 .   ? -14.50000 -4.84700  -24.65400 1.000 39.39482  ? 1441 HOH   B O    1 
HETATM 5172 O  O    . HOH   E 4 .   ? -4.85600  -5.94000  -27.00600 1.000 39.11926  ? 1442 HOH   B O    1 
HETATM 5173 O  O    . HOH   E 4 .   ? -13.91300 -40.61200 -19.67400 1.000 42.62896  ? 1443 HOH   B O    1 
HETATM 5174 O  O    . HOH   E 4 .   ? -18.87000 -16.27000 -36.02900 1.000 38.31346  ? 1444 HOH   B O    1 
HETATM 5175 O  O    . HOH   E 4 .   ? 2.85800   -36.89200 -30.67800 1.000 31.96207  ? 1445 HOH   B O    1 
HETATM 5176 O  O    . HOH   E 4 .   ? 0.81000   -36.09100 -23.62200 1.000 44.68184  ? 1446 HOH   B O    1 
HETATM 5177 O  O    . HOH   E 4 .   ? -9.00400  -24.78200 -17.56300 1.000 35.50510  ? 1447 HOH   B O    1 
HETATM 5178 O  O    . HOH   E 4 .   ? -17.543   -39.831   -47.424   1.000 37.22404  ? 1448 HOH   B O    1 
HETATM 5179 O  O    . HOH   E 4 .   ? -14.85300 -28.79200 -19.44700 1.000 38.82498  ? 1449 HOH   B O    1 
HETATM 5180 O  O    . HOH   E 4 .   ? -11.75200 -21.25600 -11.47100 1.000 40.48328  ? 1450 HOH   B O    1 
HETATM 5181 O  O    . HOH   E 4 .   ? -27.67500 -32.75200 -38.58100 1.000 41.41909  ? 1451 HOH   B O    1 
HETATM 5182 O  O    . HOH   E 4 .   ? -18.77500 -33.86500 -27.49200 1.000 22.98596  ? 1452 HOH   B O    1 
HETATM 5183 O  O    . HOH   E 4 .   ? -19.81100 -22.49400 -15.96200 1.000 26.19072  ? 1453 HOH   B O    1 
HETATM 5184 O  O    . HOH   E 4 .   ? 3.98700   -12.71300 -16.99700 1.000 53.55134  ? 1454 HOH   B O    1 
HETATM 5185 O  O    . HOH   E 4 .   ? -18.67200 -29.31200 -35.54400 1.000 26.98266  ? 1455 HOH   B O    1 
HETATM 5186 O  O    . HOH   E 4 .   ? -14.08300 -39.84000 -29.74700 1.000 30.95775  ? 1456 HOH   B O    1 
HETATM 5187 O  O    . HOH   E 4 .   ? -12.90200 -37.07500 -19.45900 1.000 43.40774  ? 1457 HOH   B O    1 
HETATM 5188 O  O    . HOH   E 4 .   ? -13.64900 -24.20800 -32.71300 1.000 31.22368  ? 1458 HOH   B O    1 
HETATM 5189 O  O    . HOH   E 4 .   ? -10.72000 -12.21100 -19.18100 1.000 36.98898  ? 1459 HOH   B O    1 
HETATM 5190 O  O    . HOH   E 4 .   ? 7.87700   -29.80200 -28.77800 1.000 55.65174  ? 1460 HOH   B O    1 
HETATM 5191 O  O    . HOH   E 4 .   ? -17.99500 -45.14000 -23.18600 1.000 28.02961  ? 1461 HOH   B O    1 
HETATM 5192 O  O    . HOH   E 4 .   ? -19.43700 -33.35500 -15.72000 1.000 36.69573  ? 1462 HOH   B O    1 
HETATM 5193 O  O    . HOH   E 4 .   ? -6.99400  -39.07800 -32.70200 1.000 26.08284  ? 1463 HOH   B O    1 
HETATM 5194 O  O    . HOH   E 4 .   ? -11.51700 -42.98800 -17.71400 1.000 44.72337  ? 1464 HOH   B O    1 
HETATM 5195 O  O    . HOH   E 4 .   ? -18.10200 -41.60600 -17.68000 1.000 36.70969  ? 1465 HOH   B O    1 
HETATM 5196 O  O    . HOH   E 4 .   ? -11.32300 -20.62800 -36.85200 1.000 30.60511  ? 1466 HOH   B O    1 
HETATM 5197 O  O    . HOH   E 4 .   ? 3.11700   -31.31800 -30.98100 1.000 42.37655  ? 1467 HOH   B O    1 
HETATM 5198 O  O    . HOH   E 4 .   ? -25.88400 -39.24800 -18.83700 1.000 38.19648  ? 1468 HOH   B O    1 
HETATM 5199 O  O    . HOH   E 4 .   ? -5.33300  -37.65300 -18.96500 1.000 44.43491  ? 1469 HOH   B O    1 
HETATM 5200 O  O    . HOH   E 4 .   ? -12.78200 -36.54700 -30.45300 1.000 30.20292  ? 1470 HOH   B O    1 
HETATM 5201 O  O    . HOH   E 4 .   ? 4.58100   -45.28700 -39.74800 1.000 46.03948  ? 1471 HOH   B O    1 
HETATM 5202 O  O    . HOH   E 4 .   ? -27.53900 -42.73200 -38.49500 1.000 38.36261  ? 1472 HOH   B O    1 
HETATM 5203 O  O    . HOH   E 4 .   ? -22.57200 -19.89900 -17.38000 1.000 39.83812  ? 1473 HOH   B O    1 
HETATM 5204 O  O    . HOH   E 4 .   ? -8.01500  -44.72700 -19.90400 1.000 31.04108  ? 1474 HOH   B O    1 
HETATM 5205 O  O    . HOH   E 4 .   ? -19.04000 -24.93100 -36.68500 1.000 30.48768  ? 1475 HOH   B O    1 
HETATM 5206 O  O    . HOH   E 4 .   ? 2.18100   -41.30400 -24.59500 1.000 41.96916  ? 1476 HOH   B O    1 
HETATM 5207 O  O    . HOH   E 4 .   ? -16.680   -52.358   -47.343   1.000 34.02551  ? 1477 HOH   B O    1 
HETATM 5208 O  O    . HOH   E 4 .   ? -19.44300 -32.98000 -34.09900 1.000 23.59098  ? 1478 HOH   B O    1 
HETATM 5209 O  O    . HOH   E 4 .   ? -28.10400 -38.41500 -37.39900 1.000 47.19392  ? 1479 HOH   B O    1 
HETATM 5210 O  O    . HOH   E 4 .   ? -21.92600 -23.64700 -44.18100 1.000 54.08633  ? 1480 HOH   B O    1 
HETATM 5211 O  O    . HOH   E 4 .   ? -6.10000  -46.16800 -31.42100 1.000 28.47848  ? 1481 HOH   B O    1 
HETATM 5212 O  O    . HOH   E 4 .   ? -8.26300  -47.63000 -31.72600 1.000 31.73870  ? 1482 HOH   B O    1 
HETATM 5213 O  O    . HOH   E 4 .   ? -16.39400 -27.72500 -30.65500 1.000 34.13481  ? 1483 HOH   B O    1 
HETATM 5214 O  O    . HOH   E 4 .   ? -36.16200 -22.24700 -28.54600 1.000 52.80106  ? 1484 HOH   B O    1 
HETATM 5215 O  O    . HOH   E 4 .   ? -14.55200 -35.84800 -35.72600 1.000 29.67052  ? 1485 HOH   B O    1 
HETATM 5216 O  O    . HOH   E 4 .   ? -11.05400 -2.53400  -34.89800 1.000 45.11609  ? 1486 HOH   B O    1 
HETATM 5217 O  O    . HOH   E 4 .   ? -7.64400  -24.03300 -23.98500 1.000 29.74612  ? 1487 HOH   B O    1 
HETATM 5218 O  O    . HOH   E 4 .   ? -15.50600 -51.54900 -20.77600 1.000 53.64090  ? 1488 HOH   B O    1 
HETATM 5219 O  O    . HOH   E 4 .   ? -14.41700 -37.10200 -21.34800 1.000 38.38488  ? 1489 HOH   B O    1 
HETATM 5220 O  O    . HOH   E 4 .   ? -2.62400  -48.01500 -46.13300 1.000 34.04520  ? 1490 HOH   B O    1 
HETATM 5221 O  O    . HOH   E 4 .   ? -7.10200  -40.25900 -46.27700 1.000 38.48104  ? 1491 HOH   B O    1 
HETATM 5222 O  O    . HOH   E 4 .   ? -18.35300 -20.12800 -41.69700 1.000 50.18064  ? 1492 HOH   B O    1 
HETATM 5223 O  O    . HOH   E 4 .   ? -14.60400 -40.08900 -41.56200 1.000 31.42020  ? 1493 HOH   B O    1 
HETATM 5224 O  O    . HOH   E 4 .   ? -9.96900  -37.65000 -27.27700 1.000 29.78230  ? 1494 HOH   B O    1 
HETATM 5225 O  O    . HOH   E 4 .   ? -17.41200 -15.21700 -14.29600 1.000 53.59716  ? 1495 HOH   B O    1 
HETATM 5226 O  O    . HOH   E 4 .   ? -17.64000 -29.96500 -12.70900 1.000 36.11202  ? 1496 HOH   B O    1 
HETATM 5227 O  O    . HOH   E 4 .   ? -15.94800 -35.12000 -19.77200 1.000 30.90958  ? 1497 HOH   B O    1 
HETATM 5228 O  O    . HOH   E 4 .   ? -1.65500  -43.23900 -23.41800 1.000 35.56288  ? 1498 HOH   B O    1 
HETATM 5229 O  O    . HOH   E 4 .   ? 4.22800   -42.36900 -30.68600 1.000 41.83803  ? 1499 HOH   B O    1 
HETATM 5230 O  O    . HOH   E 4 .   ? -20.84200 -25.41600 -10.47900 1.000 33.82470  ? 1500 HOH   B O    1 
HETATM 5231 O  O    . HOH   E 4 .   ? 6.988     -10.915   -39.757   1.000 43.15603  ? 1501 HOH   B O    1 
HETATM 5232 O  O    . HOH   E 4 .   ? -2.90600  -31.20800 -21.40700 1.000 42.70001  ? 1502 HOH   B O    1 
HETATM 5233 O  O    . HOH   E 4 .   ? 0.95300   -11.72800 -22.72200 1.000 38.26655  ? 1503 HOH   B O    1 
HETATM 5234 O  O    . HOH   E 4 .   ? -13.404   -55.970   -43.182   1.000 39.98744  ? 1504 HOH   B O    1 
HETATM 5235 O  O    . HOH   E 4 .   ? -19.82100 -31.82800 -43.42900 1.000 44.06006  ? 1505 HOH   B O    1 
HETATM 5236 O  O    . HOH   E 4 .   ? -7.46300  -25.28300 -5.70300  1.000 52.99702  ? 1506 HOH   B O    1 
HETATM 5237 O  O    . HOH   E 4 .   ? 6.92500   -29.14200 -26.29300 1.000 45.21619  ? 1507 HOH   B O    1 
HETATM 5238 O  O    . HOH   E 4 .   ? -16.75100 -36.09300 -46.85900 1.000 40.03661  ? 1508 HOH   B O    1 
HETATM 5239 O  O    . HOH   E 4 .   ? -14.85300 -32.65300 -34.62900 1.000 27.83680  ? 1509 HOH   B O    1 
HETATM 5240 O  O    . HOH   E 4 .   ? -12.45700 -33.95600 -37.58500 1.000 47.32845  ? 1510 HOH   B O    1 
HETATM 5241 O  O    . HOH   E 4 .   ? -5.59300  -43.03400 -45.34400 1.000 38.88031  ? 1511 HOH   B O    1 
HETATM 5242 O  O    . HOH   E 4 .   ? -30.64200 -37.53300 -33.12200 1.000 45.68912  ? 1512 HOH   B O    1 
HETATM 5243 O  O    . HOH   E 4 .   ? -18.75500 -5.96600  -25.14900 1.000 39.57641  ? 1513 HOH   B O    1 
HETATM 5244 O  O    . HOH   E 4 .   ? 2.76600   -29.81800 -28.52400 1.000 42.16275  ? 1514 HOH   B O    1 
HETATM 5245 O  O    . HOH   E 4 .   ? -36.37000 -28.67300 -33.37500 1.000 53.41193  ? 1515 HOH   B O    1 
HETATM 5246 O  O    . HOH   E 4 .   ? -21.19100 -14.69600 -12.69000 1.000 50.76843  ? 1516 HOH   B O    1 
HETATM 5247 O  O    . HOH   E 4 .   ? -8.72500  -23.07200 -19.91700 1.000 28.49442  ? 1517 HOH   B O    1 
HETATM 5248 O  O    . HOH   E 4 .   ? -13.56500 -28.73500 -23.13000 1.000 29.37848  ? 1518 HOH   B O    1 
HETATM 5249 O  O    . HOH   E 4 .   ? -32.87800 -24.26100 -22.17700 1.000 47.43649  ? 1519 HOH   B O    1 
HETATM 5250 O  O    . HOH   E 4 .   ? -24.36900 -22.75800 -39.05400 1.000 35.81932  ? 1520 HOH   B O    1 
HETATM 5251 O  O    . HOH   E 4 .   ? -17.74200 -40.52500 -41.58100 1.000 41.91367  ? 1521 HOH   B O    1 
HETATM 5252 O  O    . HOH   E 4 .   ? -19.12400 -42.79200 -43.35700 1.000 52.59678  ? 1522 HOH   B O    1 
HETATM 5253 O  O    . HOH   E 4 .   ? -11.21900 -23.09600 -33.30900 1.000 28.69570  ? 1523 HOH   B O    1 
HETATM 5254 O  O    . HOH   E 4 .   ? -16.54600 -18.89800 -9.84200  1.000 36.46077  ? 1524 HOH   B O    1 
HETATM 5255 O  O    . HOH   E 4 .   ? -8.63800  -33.83300 -32.30200 1.000 28.15157  ? 1525 HOH   B O    1 
HETATM 5256 O  O    . HOH   E 4 .   ? -15.65000 -26.35500 -36.24400 1.000 38.88785  ? 1526 HOH   B O    1 
HETATM 5257 O  O    . HOH   E 4 .   ? -21.35200 -42.38700 -43.52700 1.000 44.73970  ? 1527 HOH   B O    1 
HETATM 5258 O  O    . HOH   E 4 .   ? -32.47700 -27.82400 -34.18100 1.000 42.10852  ? 1528 HOH   B O    1 
HETATM 5259 O  O    . HOH   E 4 .   ? -21.27500 -21.60500 -11.72300 1.000 39.87670  ? 1529 HOH   B O    1 
HETATM 5260 O  O    . HOH   E 4 .   ? 5.18600   -23.88000 -18.74900 1.000 52.20230  ? 1530 HOH   B O    1 
HETATM 5261 O  O    . HOH   E 4 .   ? -18.34500 -47.82100 -40.93500 1.000 33.57138  ? 1531 HOH   B O    1 
HETATM 5262 O  O    . HOH   E 4 .   ? -12.79500 -6.42700  -20.84300 1.000 52.53670  ? 1532 HOH   B O    1 
HETATM 5263 O  O    . HOH   E 4 .   ? 2.971     -14.603   -10.890   1.000 59.08556  ? 1533 HOH   B O    1 
HETATM 5264 O  O    . HOH   E 4 .   ? -29.57100 -19.86900 -35.48800 1.000 44.90110  ? 1534 HOH   B O    1 
HETATM 5265 O  O    . HOH   E 4 .   ? -20.91800 -18.25500 -35.21700 1.000 41.48297  ? 1535 HOH   B O    1 
HETATM 5266 O  O    . HOH   E 4 .   ? -10.62600 -30.04600 -33.84100 1.000 44.82348  ? 1536 HOH   B O    1 
HETATM 5267 O  O    . HOH   E 4 .   ? -32.04200 -41.68600 -33.27300 1.000 46.43851  ? 1537 HOH   B O    1 
HETATM 5268 O  O    . HOH   E 4 .   ? -11.91600 -30.14500 -43.48800 1.000 34.19439  ? 1538 HOH   B O    1 
HETATM 5269 O  O    . HOH   E 4 .   ? -24.42900 -46.97100 -40.19000 1.000 51.23262  ? 1539 HOH   B O    1 
HETATM 5270 O  O    . HOH   E 4 .   ? -30.75300 -27.69400 -22.73000 1.000 42.50714  ? 1540 HOH   B O    1 
HETATM 5271 O  O    . HOH   E 4 .   ? -37.41000 -33.34200 -28.33700 1.000 49.77289  ? 1541 HOH   B O    1 
HETATM 5272 O  O    . HOH   E 4 .   ? -7.81800  -3.16400  -26.96800 1.000 35.54353  ? 1542 HOH   B O    1 
HETATM 5273 O  O    . HOH   E 4 .   ? -25.64100 -32.02800 -19.09100 1.000 34.22990  ? 1543 HOH   B O    1 
HETATM 5274 O  O    . HOH   E 4 .   ? -26.73800 -45.89000 -25.23300 1.000 40.11625  ? 1544 HOH   B O    1 
HETATM 5275 O  O    . HOH   E 4 .   ? -11.33400 -58.33200 -42.96500 1.000 46.38709  ? 1545 HOH   B O    1 
HETATM 5276 O  O    . HOH   E 4 .   ? -17.10000 -4.34200  -33.41500 1.000 58.94871  ? 1546 HOH   B O    1 
HETATM 5277 O  O    . HOH   E 4 .   ? -31.33200 -39.59000 -23.56000 1.000 39.99792  ? 1547 HOH   B O    1 
HETATM 5278 O  O    . HOH   E 4 .   ? -19.20900 -27.26100 -10.07500 1.000 27.12338  ? 1548 HOH   B O    1 
HETATM 5279 O  O    . HOH   E 4 .   ? -4.55000  -10.44300 -14.98500 1.000 56.24532  ? 1549 HOH   B O    1 
HETATM 5280 O  O    . HOH   E 4 .   ? -33.62900 -38.46100 -24.41800 1.000 49.73884  ? 1550 HOH   B O    1 
HETATM 5281 O  O    . HOH   E 4 .   ? -19.57300 -46.88000 -24.49400 1.000 29.99810  ? 1551 HOH   B O    1 
HETATM 5282 O  O    . HOH   E 4 .   ? -14.650   -38.741   -49.663   1.000 51.03692  ? 1552 HOH   B O    1 
HETATM 5283 O  O    . HOH   E 4 .   ? -33.83600 -30.47000 -36.85500 1.000 63.17868  ? 1553 HOH   B O    1 
HETATM 5284 O  O    . HOH   E 4 .   ? 2.48200   -26.64800 -43.65900 1.000 46.05788  ? 1554 HOH   B O    1 
HETATM 5285 O  O    . HOH   E 4 .   ? -27.54400 -22.73900 -37.36700 1.000 52.82951  ? 1555 HOH   B O    1 
HETATM 5286 O  O    . HOH   E 4 .   ? 4.71600   -40.45700 -37.43400 1.000 36.29162  ? 1556 HOH   B O    1 
HETATM 5287 O  O    . HOH   E 4 .   ? -10.94300 -22.22800 -13.97800 1.000 32.18108  ? 1557 HOH   B O    1 
HETATM 5288 O  O    . HOH   E 4 .   ? -14.80900 -16.27600 -13.31200 1.000 36.82052  ? 1558 HOH   B O    1 
HETATM 5289 O  O    . HOH   E 4 .   ? -8.76900  -13.04300 -18.36600 1.000 38.07585  ? 1559 HOH   B O    1 
HETATM 5290 O  O    . HOH   E 4 .   ? -16.82500 -54.22900 -32.48200 1.000 45.37144  ? 1560 HOH   B O    1 
HETATM 5291 O  O    . HOH   E 4 .   ? -16.49100 -33.14000 -13.18600 1.000 57.67081  ? 1561 HOH   B O    1 
HETATM 5292 O  O    . HOH   E 4 .   ? -7.60800  -36.39300 -31.47800 1.000 32.11026  ? 1562 HOH   B O    1 
HETATM 5293 O  O    . HOH   E 4 .   ? -6.71000  -49.37500 -19.98700 1.000 46.11485  ? 1563 HOH   B O    1 
HETATM 5294 O  O    . HOH   E 4 .   ? -11.72800 -27.13300 -39.63000 1.000 51.02912  ? 1564 HOH   B O    1 
HETATM 5295 O  O    . HOH   E 4 .   ? -10.35200 -34.85200 -47.45100 1.000 42.03483  ? 1565 HOH   B O    1 
HETATM 5296 O  O    . HOH   E 4 .   ? -32.38900 -32.10800 -34.89600 1.000 47.73572  ? 1566 HOH   B O    1 
HETATM 5297 O  O    . HOH   E 4 .   ? -4.48200  -38.23500 -32.35400 1.000 31.57298  ? 1567 HOH   B O    1 
HETATM 5298 O  O    . HOH   E 4 .   ? -24.27200 -45.06600 -42.17400 1.000 43.16532  ? 1568 HOH   B O    1 
HETATM 5299 O  O    . HOH   E 4 .   ? -10.67900 -49.73600 -20.11800 1.000 48.29828  ? 1569 HOH   B O    1 
HETATM 5300 O  O    . HOH   E 4 .   ? -28.67800 -46.60400 -27.06200 1.000 53.77428  ? 1570 HOH   B O    1 
HETATM 5301 O  O    . HOH   E 4 .   ? -27.33500 -33.78600 -41.67300 1.000 49.50411  ? 1571 HOH   B O    1 
HETATM 5302 O  O    . HOH   E 4 .   ? -31.93000 -36.20800 -34.92400 1.000 50.79045  ? 1572 HOH   B O    1 
HETATM 5303 O  O    . HOH   E 4 .   ? -30.54800 -23.09400 -20.40200 1.000 44.00495  ? 1573 HOH   B O    1 
HETATM 5304 O  O    . HOH   E 4 .   ? 0.19300   -19.72500 -13.86200 1.000 57.38112  ? 1574 HOH   B O    1 
HETATM 5305 O  O    . HOH   E 4 .   ? -23.42200 -54.24800 -18.78600 1.000 61.13762  ? 1575 HOH   B O    1 
HETATM 5306 O  O    . HOH   E 4 .   ? -19.53000 -39.45600 -16.74800 1.000 45.05054  ? 1576 HOH   B O    1 
HETATM 5307 O  O    . HOH   E 4 .   ? -26.14800 -25.89300 -41.25800 1.000 43.08599  ? 1577 HOH   B O    1 
HETATM 5308 O  O    . HOH   E 4 .   ? 2.44900   -23.08000 -19.77900 1.000 53.42014  ? 1578 HOH   B O    1 
HETATM 5309 O  O    . HOH   E 4 .   ? 2.87000   -32.45600 -33.02200 1.000 45.64478  ? 1579 HOH   B O    1 
HETATM 5310 O  O    . HOH   E 4 .   ? 1.97500   -7.30500  -40.87400 1.000 47.83290  ? 1580 HOH   B O    1 
HETATM 5311 O  O    . HOH   E 4 .   ? -25.60400 -50.74900 -28.88800 1.000 45.17386  ? 1581 HOH   B O    1 
HETATM 5312 O  O    . HOH   E 4 .   ? -9.46600  -53.02700 -26.44100 1.000 40.40653  ? 1582 HOH   B O    1 
HETATM 5313 O  O    . HOH   E 4 .   ? -12.31400 -17.96400 -13.57900 1.000 43.50970  ? 1583 HOH   B O    1 
HETATM 5314 O  O    . HOH   E 4 .   ? 3.56900   -32.19900 -25.37300 1.000 44.15193  ? 1584 HOH   B O    1 
HETATM 5315 O  O    . HOH   E 4 .   ? -31.17700 -42.27500 -25.80600 1.000 45.95325  ? 1585 HOH   B O    1 
HETATM 5316 O  O    . HOH   E 4 .   ? -31.05000 -25.42800 -21.90000 1.000 34.51970  ? 1586 HOH   B O    1 
HETATM 5317 O  O    . HOH   E 4 .   ? -3.85100  -24.94600 -45.80300 1.000 37.07426  ? 1587 HOH   B O    1 
HETATM 5318 O  O    . HOH   E 4 .   ? 11.15600  -25.36300 -27.50400 1.000 65.03697  ? 1588 HOH   B O    1 
HETATM 5319 O  O    . HOH   E 4 .   ? -9.83800  -52.22000 -33.42500 1.000 36.46815  ? 1589 HOH   B O    1 
HETATM 5320 O  O    . HOH   E 4 .   ? -21.85400 -10.24500 -20.50000 1.000 42.69025  ? 1590 HOH   B O    1 
HETATM 5321 O  O    . HOH   E 4 .   ? -21.25800 -20.34600 -15.22300 1.000 29.86633  ? 1591 HOH   B O    1 
HETATM 5322 O  O    . HOH   E 4 .   ? 1.61300   -46.60600 -41.96000 1.000 38.26403  ? 1592 HOH   B O    1 
HETATM 5323 O  O    . HOH   E 4 .   ? -9.73800  -23.99100 -37.04400 1.000 28.12648  ? 1593 HOH   B O    1 
HETATM 5324 O  O    . HOH   E 4 .   ? -27.82900 -30.57500 -19.62900 1.000 37.55355  ? 1594 HOH   B O    1 
HETATM 5325 O  O    . HOH   E 4 .   ? -33.62300 -18.85900 -29.71200 1.000 56.32924  ? 1595 HOH   B O    1 
HETATM 5326 O  O    . HOH   E 4 .   ? -18.07100 -26.18700 -39.03700 1.000 36.16788  ? 1596 HOH   B O    1 
HETATM 5327 O  O    . HOH   E 4 .   ? -19.86200 -31.53000 -13.10500 1.000 45.00706  ? 1597 HOH   B O    1 
HETATM 5328 O  O    . HOH   E 4 .   ? 2.50900   -25.98400 -18.83300 1.000 53.46266  ? 1598 HOH   B O    1 
HETATM 5329 O  O    . HOH   E 4 .   ? -11.652   -45.948   -52.254   1.000 47.34670  ? 1599 HOH   B O    1 
HETATM 5330 O  O    . HOH   E 4 .   ? -29.38300 -29.85300 -21.48200 1.000 45.00615  ? 1600 HOH   B O    1 
HETATM 5331 O  O    . HOH   E 4 .   ? -18.05400 -54.33400 -36.80900 1.000 52.59155  ? 1601 HOH   B O    1 
HETATM 5332 O  O    . HOH   E 4 .   ? -26.41600 -26.65600 -12.25700 1.000 39.90915  ? 1602 HOH   B O    1 
HETATM 5333 O  O    . HOH   E 4 .   ? -2.94500  -43.48700 -47.99600 1.000 46.65616  ? 1603 HOH   B O    1 
HETATM 5334 O  O    . HOH   E 4 .   ? -9.98900  -36.38500 -29.64000 1.000 25.25984  ? 1604 HOH   B O    1 
HETATM 5335 O  O    . HOH   E 4 .   ? -31.52600 -21.77600 -29.95300 1.000 48.01772  ? 1605 HOH   B O    1 
HETATM 5336 O  O    . HOH   E 4 .   ? -18.93500 -44.43100 -17.08500 1.000 48.53301  ? 1606 HOH   B O    1 
HETATM 5337 O  O    . HOH   E 4 .   ? -9.62200  -35.13900 -18.33000 1.000 44.68246  ? 1607 HOH   B O    1 
HETATM 5338 O  O    . HOH   E 4 .   ? -5.57500  -13.29400 -15.60800 1.000 58.23690  ? 1608 HOH   B O    1 
HETATM 5339 O  O    . HOH   E 4 .   ? -5.66200  -24.51200 -7.80100  1.000 63.12013  ? 1609 HOH   B O    1 
HETATM 5340 O  O    . HOH   E 4 .   ? -22.97200 -14.99900 -41.85800 1.000 60.92894  ? 1610 HOH   B O    1 
HETATM 5341 O  O    . HOH   E 4 .   ? -33.78000 -21.30900 -28.64700 1.000 51.59533  ? 1611 HOH   B O    1 
HETATM 5342 O  O    . HOH   E 4 .   ? -6.94200  -12.68700 -17.34600 1.000 49.80195  ? 1612 HOH   B O    1 
HETATM 5343 O  O    . HOH   E 4 .   ? -29.04900 -15.52700 -31.79600 1.000 49.71679  ? 1613 HOH   B O    1 
HETATM 5344 O  O    . HOH   E 4 .   ? -36.51200 -31.79400 -30.30200 1.000 56.35420  ? 1614 HOH   B O    1 
HETATM 5345 O  O    . HOH   E 4 .   ? -4.68100  -2.59000  -22.68800 1.000 51.06019  ? 1615 HOH   B O    1 
HETATM 5346 O  O    . HOH   E 4 .   ? -30.00800 -53.87200 -30.39300 1.000 66.71493  ? 1616 HOH   B O    1 
HETATM 5347 O  O    . HOH   E 4 .   ? -18.21000 -16.02100 -10.17600 1.000 41.62582  ? 1617 HOH   B O    1 
HETATM 5348 O  O    . HOH   E 4 .   ? -11.01100 -32.62300 -32.88700 1.000 34.34862  ? 1618 HOH   B O    1 
HETATM 5349 O  O    . HOH   E 4 .   ? -0.01600  -25.38700 -43.66000 1.000 48.90120  ? 1619 HOH   B O    1 
HETATM 5350 O  O    . HOH   E 4 .   ? -13.82200 -2.69000  -25.67900 1.000 45.86030  ? 1620 HOH   B O    1 
HETATM 5351 O  O    . HOH   E 4 .   ? -29.09300 -17.90800 -39.79100 1.000 59.46145  ? 1621 HOH   B O    1 
HETATM 5352 O  O    . HOH   E 4 .   ? -25.97400 -34.74000 -18.36500 1.000 43.52642  ? 1622 HOH   B O    1 
HETATM 5353 O  O    . HOH   E 4 .   ? -11.02200 -52.15400 -35.37800 1.000 38.13416  ? 1623 HOH   B O    1 
HETATM 5354 O  O    . HOH   E 4 .   ? -13.04300 -31.68200 -46.58200 1.000 53.52733  ? 1624 HOH   B O    1 
HETATM 5355 O  O    . HOH   E 4 .   ? -10.90600 -32.67700 -36.35500 1.000 40.68488  ? 1625 HOH   B O    1 
HETATM 5356 O  O    . HOH   E 4 .   ? -25.45400 -13.04200 -36.66900 1.000 58.43200  ? 1626 HOH   B O    1 
HETATM 5357 O  O    . HOH   E 4 .   ? -27.83300 -44.29100 -41.35300 1.000 58.17500  ? 1627 HOH   B O    1 
HETATM 5358 O  O    . HOH   E 4 .   ? 4.01400   -17.41700 -45.29100 1.000 54.31673  ? 1628 HOH   B O    1 
HETATM 5359 O  O    . HOH   E 4 .   ? -15.12200 -34.26300 -21.75900 1.000 51.56054  ? 1629 HOH   B O    1 
HETATM 5360 O  O    . HOH   E 4 .   ? -12.31000 -24.71200 -38.05300 1.000 54.05559  ? 1630 HOH   B O    1 
HETATM 5361 O  O    . HOH   E 4 .   ? -12.98000 -18.70500 -11.26700 1.000 49.61120  ? 1631 HOH   B O    1 
HETATM 5362 O  O    . HOH   E 4 .   ? -14.82200 -28.76400 -32.53400 1.000 39.02648  ? 1632 HOH   B O    1 
HETATM 5363 O  O    . HOH   E 4 .   ? -33.08900 -16.95000 -24.83800 1.000 48.03544  ? 1633 HOH   B O    1 
HETATM 5364 O  O    . HOH   E 4 .   ? -27.93000 -37.90800 -40.57600 1.000 53.37720  ? 1634 HOH   B O    1 
HETATM 5365 O  O    . HOH   E 4 .   ? 2.10900   -43.72100 -42.34200 1.000 50.59168  ? 1635 HOH   B O    1 
HETATM 5366 O  O    . HOH   E 4 .   ? -15.89700 -41.79500 -16.67000 1.000 47.93458  ? 1636 HOH   B O    1 
HETATM 5367 O  O    . HOH   E 4 .   ? 9.80400   -23.76000 -36.92900 1.000 51.04251  ? 1637 HOH   B O    1 
HETATM 5368 O  O    . HOH   E 4 .   ? -16.44600 -16.02900 -11.89000 1.000 45.66728  ? 1638 HOH   B O    1 
HETATM 5369 O  O    . HOH   E 4 .   ? -18.98600 -19.92700 -9.35700  1.000 39.30811  ? 1639 HOH   B O    1 
HETATM 5370 O  O    . HOH   E 4 .   ? -26.36400 -49.61700 -25.97700 1.000 53.45360  ? 1640 HOH   B O    1 
HETATM 5371 O  O    . HOH   E 4 .   ? -15.97400 -30.10900 -34.96300 1.000 39.37327  ? 1641 HOH   B O    1 
HETATM 5372 O  O    . HOH   E 4 .   ? -13.48800 -46.54900 -15.41300 1.000 49.98457  ? 1642 HOH   B O    1 
HETATM 5373 O  O    . HOH   E 4 .   ? -18.48700 -28.79400 -38.26100 1.000 37.45664  ? 1643 HOH   B O    1 
HETATM 5374 O  O    . HOH   E 4 .   ? -23.39000 -31.66600 -9.29000  1.000 50.39100  ? 1644 HOH   B O    1 
HETATM 5375 O  O    . HOH   E 4 .   ? -13.42100 -55.91600 -37.65500 1.000 49.67628  ? 1645 HOH   B O    1 
HETATM 5376 O  O    . HOH   E 4 .   ? -14.72600 -30.88700 -12.97900 1.000 43.64865  ? 1646 HOH   B O    1 
HETATM 5377 O  O    . HOH   E 4 .   ? -17.11100 -4.45300  -23.87900 1.000 52.10726  ? 1647 HOH   B O    1 
HETATM 5378 O  O    . HOH   E 4 .   ? -12.33500 -34.09000 -47.51600 1.000 42.13895  ? 1648 HOH   B O    1 
HETATM 5379 O  O    . HOH   E 4 .   ? -13.13800 -33.53600 -35.30000 1.000 46.29698  ? 1649 HOH   B O    1 
HETATM 5380 O  O    . HOH   E 4 .   ? 4.002     -7.108    -42.053   1.000 43.16227  ? 1650 HOH   B O    1 
HETATM 5381 O  O    . HOH   E 4 .   ? 4.18000   -25.34500 -44.90100 1.000 54.68681  ? 1651 HOH   B O    1 
HETATM 5382 O  O    . HOH   E 4 .   ? -23.53600 -20.99200 -43.44600 1.000 49.36058  ? 1652 HOH   B O    1 
HETATM 5383 O  O    . HOH   E 4 .   ? -20.66300 -16.25900 -9.28600  1.000 45.65115  ? 1653 HOH   B O    1 
HETATM 5384 O  O    . HOH   E 4 .   ? -25.86500 -12.53600 -21.22700 1.000 54.50187  ? 1654 HOH   B O    1 
HETATM 5385 O  O    . HOH   E 4 .   ? -31.90600 -24.45200 -19.78800 1.000 51.78251  ? 1655 HOH   B O    1 
HETATM 5386 O  O    . HOH   E 4 .   ? -23.57900 -12.01000 -21.54500 1.000 47.82735  ? 1656 HOH   B O    1 
HETATM 5387 O  O    . HOH   E 4 .   ? 4.56500   -34.84000 -30.82000 1.000 46.15221  ? 1657 HOH   B O    1 
HETATM 5388 O  O    . HOH   E 4 .   ? 4.95300   -31.30900 -27.76200 1.000 47.59899  ? 1658 HOH   B O    1 
HETATM 5389 O  O    . HOH   E 4 .   ? -15.271   -36.150   -49.398   1.000 52.70889  ? 1659 HOH   B O    1 
HETATM 5390 O  O    . HOH   E 4 .   ? -30.99500 -44.78900 -26.63700 1.000 54.64974  ? 1660 HOH   B O    1 
HETATM 5391 O  O    . HOH   E 4 .   ? -24.91700 -20.10800 -13.99300 1.000 46.42845  ? 1661 HOH   B O    1 
HETATM 5392 O  O    . HOH   E 4 .   ? -18.03300 -38.28900 -15.52500 1.000 43.17753  ? 1662 HOH   B O    1 
HETATM 5393 O  O    . HOH   E 4 .   ? -20.35600 -31.30300 -9.48900  1.000 45.79869  ? 1663 HOH   B O    1 
HETATM 5394 O  O    . HOH   E 4 .   ? -18.970   -37.642   -46.437   1.000 37.19903  ? 1664 HOH   B O    1 
HETATM 5395 O  O    . HOH   E 4 .   ? -29.11000 -39.82900 -38.93200 1.000 47.26763  ? 1665 HOH   B O    1 
HETATM 5396 O  O    . HOH   E 4 .   ? -24.58500 -23.22900 -42.09700 1.000 42.72578  ? 1666 HOH   B O    1 
HETATM 5397 O  O    . HOH   E 4 .   ? -11.47900 -40.60600 -16.80700 1.000 44.57626  ? 1667 HOH   B O    1 
HETATM 5398 O  O    . HOH   E 4 .   ? -13.48700 -32.47000 -39.49000 1.000 49.90364  ? 1668 HOH   B O    1 
HETATM 5399 O  O    . HOH   E 4 .   ? -40.99400 -30.53000 -28.53800 1.000 54.19895  ? 1669 HOH   B O    1 
HETATM 5400 O  O    . HOH   E 4 .   ? -35.93500 -21.54600 -26.14300 1.000 45.83644  ? 1670 HOH   B O    1 
HETATM 5401 O  O    . HOH   E 4 .   ? -12.51300 -22.89800 -36.13600 1.000 43.38047  ? 1671 HOH   B O    1 
HETATM 5402 O  O    . HOH   E 4 .   ? -1.37000  -25.47500 -46.05600 1.000 49.69621  ? 1672 HOH   B O    1 
HETATM 5403 O  O    . HOH   E 4 .   ? -21.35100 -5.72100  -25.32800 1.000 57.50307  ? 1673 HOH   B O    1 
HETATM 5404 O  O    . HOH   E 4 .   ? -14.74100 -23.80300 -36.24400 1.000 45.08093  ? 1674 HOH   B O    1 
HETATM 5405 O  O    . HOH   E 4 .   ? -19.56400 -54.50500 -31.09000 1.000 52.62451  ? 1675 HOH   B O    1 
HETATM 5406 O  O    . HOH   E 4 .   ? -5.61900  -6.14200  -43.15100 1.000 52.72174  ? 1676 HOH   B O    1 
HETATM 5407 O  O    . HOH   E 4 .   ? -18.72500 -33.67000 -46.25300 1.000 52.95024  ? 1677 HOH   B O    1 
HETATM 5408 O  O    . HOH   E 4 .   ? -19.62600 -31.50100 -47.51600 1.000 62.49749  ? 1678 HOH   B O    1 
HETATM 5409 O  O    . HOH   E 4 .   ? -2.49500  -45.94500 -49.66300 1.000 57.63245  ? 1679 HOH   B O    1 
HETATM 5410 O  O    . HOH   E 4 .   ? -12.76500 -30.83200 -40.96900 1.000 45.05728  ? 1680 HOH   B O    1 
HETATM 5411 O  O    . HOH   E 4 .   ? -33.41000 -50.26600 -35.29000 1.000 52.66426  ? 1681 HOH   B O    1 
HETATM 5412 O  O    . HOH   E 4 .   ? -25.71800 -48.32200 -18.92200 1.000 47.46675  ? 1682 HOH   B O    1 
HETATM 5413 O  O    . HOH   E 4 .   ? -23.16400 -60.35000 -21.22800 1.000 60.80350  ? 1683 HOH   B O    1 
HETATM 5414 O  O    . HOH   E 4 .   ? -8.67800  2.36200   -23.07400 1.000 61.47099  ? 1684 HOH   B O    1 
HETATM 5415 O  O    . HOH   E 4 .   ? -37.17400 -30.62300 -37.14900 1.000 68.34927  ? 1685 HOH   B O    1 
HETATM 5416 O  O    . HOH   E 4 .   ? 10.97400  -38.93100 -49.57100 1.000 58.29667  ? 1686 HOH   B O    1 
HETATM 5417 O  O    . HOH   E 4 .   ? 13.42100  -19.16600 -54.28200 1.000 63.95553  ? 1687 HOH   B O    1 
HETATM 5418 O  O    . HOH   E 4 .   ? -47.54100 -21.10100 -37.62500 1.000 73.17301  ? 1688 HOH   B O    1 
# 
