data_9AWZ
# 
_entry.id   9AWZ 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9AWZ         pdb_00009awz 10.2210/pdb9awz/pdb 
WWPDB D_1000282219 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-03-12 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9AWZ 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-05 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              luismauriciolima@gmail.com 
_pdbx_contact_author.name_first         Luis 
_pdbx_contact_author.name_last          Lima 
_pdbx_contact_author.name_mi            T.R. 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-6020-0504 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Lima, L.M.T.R.'    1 0000-0001-6020-0504 
'de Sa Ribeiro, F.' 2 0000-0002-8521-6745 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Crystal structure of trypsin at 300 Kelvin with benzamidine (triplicate)' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Lima, L.M.T.R.'    1 0000-0001-6020-0504 
primary 'de Sa Ribeiro, F.' 2 0000-0002-8521-6745 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Cationic trypsin' 23324.287 1  3.4.21.4 ? ? ? 
2 non-polymer syn 'CALCIUM ION'      40.078    1  ?        ? ? ? 
3 non-polymer syn BENZAMIDINE        120.152   1  ?        ? ? ? 
4 water       nat water              18.015    80 ?        ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        Beta-trypsin 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNT
LNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNM
FCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN
;
_entity_poly.pdbx_seq_one_letter_code_can   
;IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNT
LNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNM
FCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'CALCIUM ION' CA  
3 BENZAMIDINE   BEN 
4 water         HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ILE n 
1 2   VAL n 
1 3   GLY n 
1 4   GLY n 
1 5   TYR n 
1 6   THR n 
1 7   CYS n 
1 8   GLY n 
1 9   ALA n 
1 10  ASN n 
1 11  THR n 
1 12  VAL n 
1 13  PRO n 
1 14  TYR n 
1 15  GLN n 
1 16  VAL n 
1 17  SER n 
1 18  LEU n 
1 19  ASN n 
1 20  SER n 
1 21  GLY n 
1 22  TYR n 
1 23  HIS n 
1 24  PHE n 
1 25  CYS n 
1 26  GLY n 
1 27  GLY n 
1 28  SER n 
1 29  LEU n 
1 30  ILE n 
1 31  ASN n 
1 32  SER n 
1 33  GLN n 
1 34  TRP n 
1 35  VAL n 
1 36  VAL n 
1 37  SER n 
1 38  ALA n 
1 39  ALA n 
1 40  HIS n 
1 41  CYS n 
1 42  TYR n 
1 43  LYS n 
1 44  SER n 
1 45  GLY n 
1 46  ILE n 
1 47  GLN n 
1 48  VAL n 
1 49  ARG n 
1 50  LEU n 
1 51  GLY n 
1 52  GLU n 
1 53  ASP n 
1 54  ASN n 
1 55  ILE n 
1 56  ASN n 
1 57  VAL n 
1 58  VAL n 
1 59  GLU n 
1 60  GLY n 
1 61  ASN n 
1 62  GLU n 
1 63  GLN n 
1 64  PHE n 
1 65  ILE n 
1 66  SER n 
1 67  ALA n 
1 68  SER n 
1 69  LYS n 
1 70  SER n 
1 71  ILE n 
1 72  VAL n 
1 73  HIS n 
1 74  PRO n 
1 75  SER n 
1 76  TYR n 
1 77  ASN n 
1 78  SER n 
1 79  ASN n 
1 80  THR n 
1 81  LEU n 
1 82  ASN n 
1 83  ASN n 
1 84  ASP n 
1 85  ILE n 
1 86  MET n 
1 87  LEU n 
1 88  ILE n 
1 89  LYS n 
1 90  LEU n 
1 91  LYS n 
1 92  SER n 
1 93  ALA n 
1 94  ALA n 
1 95  SER n 
1 96  LEU n 
1 97  ASN n 
1 98  SER n 
1 99  ARG n 
1 100 VAL n 
1 101 ALA n 
1 102 SER n 
1 103 ILE n 
1 104 SER n 
1 105 LEU n 
1 106 PRO n 
1 107 THR n 
1 108 SER n 
1 109 CYS n 
1 110 ALA n 
1 111 SER n 
1 112 ALA n 
1 113 GLY n 
1 114 THR n 
1 115 GLN n 
1 116 CYS n 
1 117 LEU n 
1 118 ILE n 
1 119 SER n 
1 120 GLY n 
1 121 TRP n 
1 122 GLY n 
1 123 ASN n 
1 124 THR n 
1 125 LYS n 
1 126 SER n 
1 127 SER n 
1 128 GLY n 
1 129 THR n 
1 130 SER n 
1 131 TYR n 
1 132 PRO n 
1 133 ASP n 
1 134 VAL n 
1 135 LEU n 
1 136 LYS n 
1 137 CYS n 
1 138 LEU n 
1 139 LYS n 
1 140 ALA n 
1 141 PRO n 
1 142 ILE n 
1 143 LEU n 
1 144 SER n 
1 145 ASP n 
1 146 SER n 
1 147 SER n 
1 148 CYS n 
1 149 LYS n 
1 150 SER n 
1 151 ALA n 
1 152 TYR n 
1 153 PRO n 
1 154 GLY n 
1 155 GLN n 
1 156 ILE n 
1 157 THR n 
1 158 SER n 
1 159 ASN n 
1 160 MET n 
1 161 PHE n 
1 162 CYS n 
1 163 ALA n 
1 164 GLY n 
1 165 TYR n 
1 166 LEU n 
1 167 GLU n 
1 168 GLY n 
1 169 GLY n 
1 170 LYS n 
1 171 ASP n 
1 172 SER n 
1 173 CYS n 
1 174 GLN n 
1 175 GLY n 
1 176 ASP n 
1 177 SER n 
1 178 GLY n 
1 179 GLY n 
1 180 PRO n 
1 181 VAL n 
1 182 VAL n 
1 183 CYS n 
1 184 SER n 
1 185 GLY n 
1 186 LYS n 
1 187 LEU n 
1 188 GLN n 
1 189 GLY n 
1 190 ILE n 
1 191 VAL n 
1 192 SER n 
1 193 TRP n 
1 194 GLY n 
1 195 SER n 
1 196 GLY n 
1 197 CYS n 
1 198 ALA n 
1 199 GLN n 
1 200 LYS n 
1 201 ASN n 
1 202 LYS n 
1 203 PRO n 
1 204 GLY n 
1 205 VAL n 
1 206 TYR n 
1 207 THR n 
1 208 LYS n 
1 209 VAL n 
1 210 CYS n 
1 211 ASN n 
1 212 TYR n 
1 213 VAL n 
1 214 SER n 
1 215 TRP n 
1 216 ILE n 
1 217 LYS n 
1 218 GLN n 
1 219 THR n 
1 220 ILE n 
1 221 ALA n 
1 222 SER n 
1 223 ASN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   223 
_entity_src_gen.gene_src_common_name               cattle 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Bos taurus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9913 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Bos taurus' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9913 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
BEN non-polymer         . BENZAMIDINE     ? 'C7 H8 N2'       120.152 
CA  non-polymer         . 'CALCIUM ION'   ? 'Ca 2'           40.078  
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ILE 1   1   1   ILE ILE A . n 
A 1 2   VAL 2   2   2   VAL VAL A . n 
A 1 3   GLY 3   3   3   GLY GLY A . n 
A 1 4   GLY 4   4   4   GLY GLY A . n 
A 1 5   TYR 5   5   5   TYR TYR A . n 
A 1 6   THR 6   6   6   THR THR A . n 
A 1 7   CYS 7   7   7   CYS CYS A . n 
A 1 8   GLY 8   8   8   GLY GLY A . n 
A 1 9   ALA 9   9   9   ALA ALA A . n 
A 1 10  ASN 10  10  10  ASN ASN A . n 
A 1 11  THR 11  11  11  THR THR A . n 
A 1 12  VAL 12  12  12  VAL VAL A . n 
A 1 13  PRO 13  13  13  PRO PRO A . n 
A 1 14  TYR 14  14  14  TYR TYR A . n 
A 1 15  GLN 15  15  15  GLN GLN A . n 
A 1 16  VAL 16  16  16  VAL VAL A . n 
A 1 17  SER 17  17  17  SER SER A . n 
A 1 18  LEU 18  18  18  LEU LEU A . n 
A 1 19  ASN 19  19  19  ASN ASN A . n 
A 1 20  SER 20  20  20  SER SER A . n 
A 1 21  GLY 21  21  21  GLY GLY A . n 
A 1 22  TYR 22  22  22  TYR TYR A . n 
A 1 23  HIS 23  23  23  HIS HIS A . n 
A 1 24  PHE 24  24  24  PHE PHE A . n 
A 1 25  CYS 25  25  25  CYS CYS A . n 
A 1 26  GLY 26  26  26  GLY GLY A . n 
A 1 27  GLY 27  27  27  GLY GLY A . n 
A 1 28  SER 28  28  28  SER SER A . n 
A 1 29  LEU 29  29  29  LEU LEU A . n 
A 1 30  ILE 30  30  30  ILE ILE A . n 
A 1 31  ASN 31  31  31  ASN ASN A . n 
A 1 32  SER 32  32  32  SER SER A . n 
A 1 33  GLN 33  33  33  GLN GLN A . n 
A 1 34  TRP 34  34  34  TRP TRP A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  SER 37  37  37  SER SER A . n 
A 1 38  ALA 38  38  38  ALA ALA A . n 
A 1 39  ALA 39  39  39  ALA ALA A . n 
A 1 40  HIS 40  40  40  HIS HIS A . n 
A 1 41  CYS 41  41  41  CYS CYS A . n 
A 1 42  TYR 42  42  42  TYR TYR A . n 
A 1 43  LYS 43  43  43  LYS LYS A . n 
A 1 44  SER 44  44  44  SER SER A . n 
A 1 45  GLY 45  45  45  GLY GLY A . n 
A 1 46  ILE 46  46  46  ILE ILE A . n 
A 1 47  GLN 47  47  47  GLN GLN A . n 
A 1 48  VAL 48  48  48  VAL VAL A . n 
A 1 49  ARG 49  49  49  ARG ARG A . n 
A 1 50  LEU 50  50  50  LEU LEU A . n 
A 1 51  GLY 51  51  51  GLY GLY A . n 
A 1 52  GLU 52  52  52  GLU GLU A . n 
A 1 53  ASP 53  53  53  ASP ASP A . n 
A 1 54  ASN 54  54  54  ASN ASN A . n 
A 1 55  ILE 55  55  55  ILE ILE A . n 
A 1 56  ASN 56  56  56  ASN ASN A . n 
A 1 57  VAL 57  57  57  VAL VAL A . n 
A 1 58  VAL 58  58  58  VAL VAL A . n 
A 1 59  GLU 59  59  59  GLU GLU A . n 
A 1 60  GLY 60  60  60  GLY GLY A . n 
A 1 61  ASN 61  61  61  ASN ASN A . n 
A 1 62  GLU 62  62  62  GLU GLU A . n 
A 1 63  GLN 63  63  63  GLN GLN A . n 
A 1 64  PHE 64  64  64  PHE PHE A . n 
A 1 65  ILE 65  65  65  ILE ILE A . n 
A 1 66  SER 66  66  66  SER SER A . n 
A 1 67  ALA 67  67  67  ALA ALA A . n 
A 1 68  SER 68  68  68  SER SER A . n 
A 1 69  LYS 69  69  69  LYS LYS A . n 
A 1 70  SER 70  70  70  SER SER A . n 
A 1 71  ILE 71  71  71  ILE ILE A . n 
A 1 72  VAL 72  72  72  VAL VAL A . n 
A 1 73  HIS 73  73  73  HIS HIS A . n 
A 1 74  PRO 74  74  74  PRO PRO A . n 
A 1 75  SER 75  75  75  SER SER A . n 
A 1 76  TYR 76  76  76  TYR TYR A . n 
A 1 77  ASN 77  77  77  ASN ASN A . n 
A 1 78  SER 78  78  78  SER SER A . n 
A 1 79  ASN 79  79  79  ASN ASN A . n 
A 1 80  THR 80  80  80  THR THR A . n 
A 1 81  LEU 81  81  81  LEU LEU A . n 
A 1 82  ASN 82  82  82  ASN ASN A . n 
A 1 83  ASN 83  83  83  ASN ASN A . n 
A 1 84  ASP 84  84  84  ASP ASP A . n 
A 1 85  ILE 85  85  85  ILE ILE A . n 
A 1 86  MET 86  86  86  MET MET A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  ILE 88  88  88  ILE ILE A . n 
A 1 89  LYS 89  89  89  LYS LYS A . n 
A 1 90  LEU 90  90  90  LEU LEU A . n 
A 1 91  LYS 91  91  91  LYS LYS A . n 
A 1 92  SER 92  92  92  SER SER A . n 
A 1 93  ALA 93  93  93  ALA ALA A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  SER 95  95  95  SER SER A . n 
A 1 96  LEU 96  96  96  LEU LEU A . n 
A 1 97  ASN 97  97  97  ASN ASN A . n 
A 1 98  SER 98  98  98  SER SER A . n 
A 1 99  ARG 99  99  99  ARG ARG A . n 
A 1 100 VAL 100 100 100 VAL VAL A . n 
A 1 101 ALA 101 101 101 ALA ALA A . n 
A 1 102 SER 102 102 102 SER SER A . n 
A 1 103 ILE 103 103 103 ILE ILE A . n 
A 1 104 SER 104 104 104 SER SER A . n 
A 1 105 LEU 105 105 105 LEU LEU A . n 
A 1 106 PRO 106 106 106 PRO PRO A . n 
A 1 107 THR 107 107 107 THR THR A . n 
A 1 108 SER 108 108 108 SER SER A . n 
A 1 109 CYS 109 109 109 CYS CYS A . n 
A 1 110 ALA 110 110 110 ALA ALA A . n 
A 1 111 SER 111 111 111 SER SER A . n 
A 1 112 ALA 112 112 112 ALA ALA A . n 
A 1 113 GLY 113 113 113 GLY GLY A . n 
A 1 114 THR 114 114 114 THR THR A . n 
A 1 115 GLN 115 115 115 GLN GLN A . n 
A 1 116 CYS 116 116 116 CYS CYS A . n 
A 1 117 LEU 117 117 117 LEU LEU A . n 
A 1 118 ILE 118 118 118 ILE ILE A . n 
A 1 119 SER 119 119 119 SER SER A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 TRP 121 121 121 TRP TRP A . n 
A 1 122 GLY 122 122 122 GLY GLY A . n 
A 1 123 ASN 123 123 123 ASN ASN A . n 
A 1 124 THR 124 124 124 THR THR A . n 
A 1 125 LYS 125 125 125 LYS LYS A . n 
A 1 126 SER 126 126 126 SER SER A . n 
A 1 127 SER 127 127 127 SER SER A . n 
A 1 128 GLY 128 128 128 GLY GLY A . n 
A 1 129 THR 129 129 129 THR THR A . n 
A 1 130 SER 130 130 130 SER SER A . n 
A 1 131 TYR 131 131 131 TYR TYR A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 ASP 133 133 133 ASP ASP A . n 
A 1 134 VAL 134 134 134 VAL VAL A . n 
A 1 135 LEU 135 135 135 LEU LEU A . n 
A 1 136 LYS 136 136 136 LYS LYS A . n 
A 1 137 CYS 137 137 137 CYS CYS A . n 
A 1 138 LEU 138 138 138 LEU LEU A . n 
A 1 139 LYS 139 139 139 LYS LYS A . n 
A 1 140 ALA 140 140 140 ALA ALA A . n 
A 1 141 PRO 141 141 141 PRO PRO A . n 
A 1 142 ILE 142 142 142 ILE ILE A . n 
A 1 143 LEU 143 143 143 LEU LEU A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 ASP 145 145 145 ASP ASP A . n 
A 1 146 SER 146 146 146 SER SER A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 CYS 148 148 148 CYS CYS A . n 
A 1 149 LYS 149 149 149 LYS LYS A . n 
A 1 150 SER 150 150 150 SER SER A . n 
A 1 151 ALA 151 151 151 ALA ALA A . n 
A 1 152 TYR 152 152 152 TYR TYR A . n 
A 1 153 PRO 153 153 153 PRO PRO A . n 
A 1 154 GLY 154 154 154 GLY GLY A . n 
A 1 155 GLN 155 155 155 GLN GLN A . n 
A 1 156 ILE 156 156 156 ILE ILE A . n 
A 1 157 THR 157 157 157 THR THR A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 ASN 159 159 159 ASN ASN A . n 
A 1 160 MET 160 160 160 MET MET A . n 
A 1 161 PHE 161 161 161 PHE PHE A . n 
A 1 162 CYS 162 162 162 CYS CYS A . n 
A 1 163 ALA 163 163 163 ALA ALA A . n 
A 1 164 GLY 164 164 164 GLY GLY A . n 
A 1 165 TYR 165 165 165 TYR TYR A . n 
A 1 166 LEU 166 166 166 LEU LEU A . n 
A 1 167 GLU 167 167 167 GLU GLU A . n 
A 1 168 GLY 168 168 168 GLY GLY A . n 
A 1 169 GLY 169 169 169 GLY GLY A . n 
A 1 170 LYS 170 170 170 LYS LYS A . n 
A 1 171 ASP 171 171 171 ASP ASP A . n 
A 1 172 SER 172 172 172 SER SER A . n 
A 1 173 CYS 173 173 173 CYS CYS A . n 
A 1 174 GLN 174 174 174 GLN GLN A . n 
A 1 175 GLY 175 175 175 GLY GLY A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 SER 177 177 177 SER SER A . n 
A 1 178 GLY 178 178 178 GLY GLY A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 PRO 180 180 180 PRO PRO A . n 
A 1 181 VAL 181 181 181 VAL VAL A . n 
A 1 182 VAL 182 182 182 VAL VAL A . n 
A 1 183 CYS 183 183 183 CYS CYS A . n 
A 1 184 SER 184 184 184 SER SER A . n 
A 1 185 GLY 185 185 185 GLY GLY A . n 
A 1 186 LYS 186 186 186 LYS LYS A . n 
A 1 187 LEU 187 187 187 LEU LEU A . n 
A 1 188 GLN 188 188 188 GLN GLN A . n 
A 1 189 GLY 189 189 189 GLY GLY A . n 
A 1 190 ILE 190 190 190 ILE ILE A . n 
A 1 191 VAL 191 191 191 VAL VAL A . n 
A 1 192 SER 192 192 192 SER SER A . n 
A 1 193 TRP 193 193 193 TRP TRP A . n 
A 1 194 GLY 194 194 194 GLY GLY A . n 
A 1 195 SER 195 195 195 SER SER A . n 
A 1 196 GLY 196 196 196 GLY GLY A . n 
A 1 197 CYS 197 197 197 CYS CYS A . n 
A 1 198 ALA 198 198 198 ALA ALA A . n 
A 1 199 GLN 199 199 199 GLN GLN A . n 
A 1 200 LYS 200 200 200 LYS LYS A . n 
A 1 201 ASN 201 201 201 ASN ASN A . n 
A 1 202 LYS 202 202 202 LYS LYS A . n 
A 1 203 PRO 203 203 203 PRO PRO A . n 
A 1 204 GLY 204 204 204 GLY GLY A . n 
A 1 205 VAL 205 205 205 VAL VAL A . n 
A 1 206 TYR 206 206 206 TYR TYR A . n 
A 1 207 THR 207 207 207 THR THR A . n 
A 1 208 LYS 208 208 208 LYS LYS A . n 
A 1 209 VAL 209 209 209 VAL VAL A . n 
A 1 210 CYS 210 210 210 CYS CYS A . n 
A 1 211 ASN 211 211 211 ASN ASN A . n 
A 1 212 TYR 212 212 212 TYR TYR A . n 
A 1 213 VAL 213 213 213 VAL VAL A . n 
A 1 214 SER 214 214 214 SER SER A . n 
A 1 215 TRP 215 215 215 TRP TRP A . n 
A 1 216 ILE 216 216 216 ILE ILE A . n 
A 1 217 LYS 217 217 217 LYS LYS A . n 
A 1 218 GLN 218 218 218 GLN GLN A . n 
A 1 219 THR 219 219 219 THR THR A . n 
A 1 220 ILE 220 220 220 ILE ILE A . n 
A 1 221 ALA 221 221 221 ALA ALA A . n 
A 1 222 SER 222 222 222 SER SER A . n 
A 1 223 ASN 223 223 223 ASN ASN A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 CA  1  301 224 CA  CA  A . 
C 3 BEN 1  302 225 BEN BEN A . 
D 4 HOH 1  401 2   HOH HOH A . 
D 4 HOH 2  402 40  HOH HOH A . 
D 4 HOH 3  403 25  HOH HOH A . 
D 4 HOH 4  404 67  HOH HOH A . 
D 4 HOH 5  405 52  HOH HOH A . 
D 4 HOH 6  406 63  HOH HOH A . 
D 4 HOH 7  407 37  HOH HOH A . 
D 4 HOH 8  408 34  HOH HOH A . 
D 4 HOH 9  409 51  HOH HOH A . 
D 4 HOH 10 410 10  HOH HOH A . 
D 4 HOH 11 411 17  HOH HOH A . 
D 4 HOH 12 412 23  HOH HOH A . 
D 4 HOH 13 413 3   HOH HOH A . 
D 4 HOH 14 414 42  HOH HOH A . 
D 4 HOH 15 415 57  HOH HOH A . 
D 4 HOH 16 416 58  HOH HOH A . 
D 4 HOH 17 417 14  HOH HOH A . 
D 4 HOH 18 418 9   HOH HOH A . 
D 4 HOH 19 419 64  HOH HOH A . 
D 4 HOH 20 420 30  HOH HOH A . 
D 4 HOH 21 421 33  HOH HOH A . 
D 4 HOH 22 422 11  HOH HOH A . 
D 4 HOH 23 423 20  HOH HOH A . 
D 4 HOH 24 424 4   HOH HOH A . 
D 4 HOH 25 425 46  HOH HOH A . 
D 4 HOH 26 426 54  HOH HOH A . 
D 4 HOH 27 427 49  HOH HOH A . 
D 4 HOH 28 428 50  HOH HOH A . 
D 4 HOH 29 429 16  HOH HOH A . 
D 4 HOH 30 430 73  HOH HOH A . 
D 4 HOH 31 431 21  HOH HOH A . 
D 4 HOH 32 432 28  HOH HOH A . 
D 4 HOH 33 433 36  HOH HOH A . 
D 4 HOH 34 434 48  HOH HOH A . 
D 4 HOH 35 435 27  HOH HOH A . 
D 4 HOH 36 436 35  HOH HOH A . 
D 4 HOH 37 437 59  HOH HOH A . 
D 4 HOH 38 438 19  HOH HOH A . 
D 4 HOH 39 439 22  HOH HOH A . 
D 4 HOH 40 440 41  HOH HOH A . 
D 4 HOH 41 441 53  HOH HOH A . 
D 4 HOH 42 442 5   HOH HOH A . 
D 4 HOH 43 443 78  HOH HOH A . 
D 4 HOH 44 444 43  HOH HOH A . 
D 4 HOH 45 445 24  HOH HOH A . 
D 4 HOH 46 446 38  HOH HOH A . 
D 4 HOH 47 447 12  HOH HOH A . 
D 4 HOH 48 448 31  HOH HOH A . 
D 4 HOH 49 449 8   HOH HOH A . 
D 4 HOH 50 450 55  HOH HOH A . 
D 4 HOH 51 451 26  HOH HOH A . 
D 4 HOH 52 452 15  HOH HOH A . 
D 4 HOH 53 453 60  HOH HOH A . 
D 4 HOH 54 454 13  HOH HOH A . 
D 4 HOH 55 455 74  HOH HOH A . 
D 4 HOH 56 456 66  HOH HOH A . 
D 4 HOH 57 457 32  HOH HOH A . 
D 4 HOH 58 458 29  HOH HOH A . 
D 4 HOH 59 459 18  HOH HOH A . 
D 4 HOH 60 460 68  HOH HOH A . 
D 4 HOH 61 461 76  HOH HOH A . 
D 4 HOH 62 462 77  HOH HOH A . 
D 4 HOH 63 463 7   HOH HOH A . 
D 4 HOH 64 464 45  HOH HOH A . 
D 4 HOH 65 465 6   HOH HOH A . 
D 4 HOH 66 466 1   HOH HOH A . 
D 4 HOH 67 467 61  HOH HOH A . 
D 4 HOH 68 468 75  HOH HOH A . 
D 4 HOH 69 469 79  HOH HOH A . 
D 4 HOH 70 470 44  HOH HOH A . 
D 4 HOH 71 471 47  HOH HOH A . 
D 4 HOH 72 472 39  HOH HOH A . 
D 4 HOH 73 473 80  HOH HOH A . 
D 4 HOH 74 474 69  HOH HOH A . 
D 4 HOH 75 475 72  HOH HOH A . 
D 4 HOH 76 476 56  HOH HOH A . 
D 4 HOH 77 477 70  HOH HOH A . 
D 4 HOH 78 478 71  HOH HOH A . 
D 4 HOH 79 479 65  HOH HOH A . 
D 4 HOH 80 480 62  HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC         ? ? ? 5.8.0425 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? 'PROTEUM PLUS' ? ? ? .        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? 'PROTEUM PLUS' ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? MOLREP         ? ? ? .        4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9AWZ 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     54.327 
_cell.length_a_esd                 ? 
_cell.length_b                     57.396 
_cell.length_b_esd                 ? 
_cell.length_c                     67.336 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9AWZ 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9AWZ 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.25 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          45.34 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              9.4 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M Potassium phosphate dibasic, 20% w/v Polyethylene glycol 3,350.' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            298 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     300 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'Bruker PHOTON II' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-11-09 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.54184 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        'BRUKER X8 PROTEUM' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.54184 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9AWZ 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.488 
_reflns.d_resolution_low                               23.12 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     34788 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.56 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                10 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          7.124 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.684 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.5 
_reflns_shell.d_res_low                                     23.12 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1760 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.684 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            0.272 
_refine.aniso_B[1][2]                            -0.000 
_refine.aniso_B[1][3]                            0.000 
_refine.aniso_B[2][2]                            -0.220 
_refine.aniso_B[2][3]                            -0.000 
_refine.aniso_B[3][3]                            -0.052 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               18.680 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.965 
_refine.correlation_coeff_Fo_to_Fc_free          0.950 
_refine.details                                  'Hydrogens have been added in their riding positions' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9AWZ 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.488 
_refine.ls_d_res_low                             23.078 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     34788 
_refine.ls_number_reflns_R_free                  1760 
_refine.ls_number_reflns_R_work                  33028 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.743 
_refine.ls_percent_reflns_R_free                 5.059 
_refine.ls_R_factor_all                          0.188 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.2261 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1861 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.073 
_refine.pdbx_overall_ESU_R_Free                  0.078 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             1.609 
_refine.overall_SU_ML                            0.057 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.488 
_refine_hist.d_res_low                        23.078 
_refine_hist.number_atoms_solvent             80 
_refine_hist.number_atoms_total               1719 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1629 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         10 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.010  0.012  1669 ? r_bond_refined_d               ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.016  1540 ? r_bond_other_d                 ? ? 
'X-RAY DIFFRACTION' ? 1.786  1.758  2263 ? r_angle_refined_deg            ? ? 
'X-RAY DIFFRACTION' ? 0.648  1.726  3563 ? r_angle_other_deg              ? ? 
'X-RAY DIFFRACTION' ? 6.516  5.000  222  ? r_dihedral_angle_1_deg         ? ? 
'X-RAY DIFFRACTION' ? 10.845 5.000  3    ? r_dihedral_angle_2_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.778  5.000  1    ? r_dihedral_angle_other_2_deg   ? ? 
'X-RAY DIFFRACTION' ? 13.053 10.000 269  ? r_dihedral_angle_3_deg         ? ? 
'X-RAY DIFFRACTION' ? 13.855 10.000 58   ? r_dihedral_angle_6_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.090  0.200  254  ? r_chiral_restr                 ? ? 
'X-RAY DIFFRACTION' ? 0.010  0.020  1978 ? r_gen_planes_refined           ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  366  ? r_gen_planes_other             ? ? 
'X-RAY DIFFRACTION' ? 0.209  0.200  292  ? r_nbd_refined                  ? ? 
'X-RAY DIFFRACTION' ? 0.203  0.200  1394 ? r_symmetry_nbd_other           ? ? 
'X-RAY DIFFRACTION' ? 0.182  0.200  845  ? r_nbtor_refined                ? ? 
'X-RAY DIFFRACTION' ? 0.089  0.200  968  ? r_symmetry_nbtor_other         ? ? 
'X-RAY DIFFRACTION' ? 0.405  0.200  64   ? r_xyhbond_nbd_refined          ? ? 
'X-RAY DIFFRACTION' ? 0.143  0.200  5    ? r_metal_ion_refined            ? ? 
'X-RAY DIFFRACTION' ? 0.200  0.200  6    ? r_symmetry_nbd_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.155  0.200  25   ? r_nbd_other                    ? ? 
'X-RAY DIFFRACTION' ? 0.240  0.200  3    ? r_symmetry_xyhbond_nbd_refined ? ? 
'X-RAY DIFFRACTION' ? 1.878  1.709  891  ? r_mcbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 1.875  1.709  891  ? r_mcbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 2.718  3.062  1112 ? r_mcangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 2.717  3.062  1113 ? r_mcangle_other                ? ? 
'X-RAY DIFFRACTION' ? 3.404  2.031  778  ? r_scbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 3.402  2.030  779  ? r_scbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 5.204  3.529  1151 ? r_scangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 5.204  3.528  1151 ? r_scangle_other                ? ? 
'X-RAY DIFFRACTION' ? 6.136  17.651 1826 ? r_lrange_it                    ? ? 
'X-RAY DIFFRACTION' ? 6.128  17.596 1820 ? r_lrange_other                 ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.488 1.527  2568 . 140 2162 89.6417  . 0.377 . . 0.377 . . . . . 0.372 . 20 . 0.882 0.867 0.381 
'X-RAY DIFFRACTION' 1.527 1.568  2481 . 110 2274 96.0903  . 0.354 . . 0.352 . . . . . 0.338 . 20 . 0.899 0.898 0.395 
'X-RAY DIFFRACTION' 1.568 1.614  2430 . 101 2285 98.1893  . 0.295 . . 0.295 . . . . . 0.272 . 20 . 0.930 0.935 0.296 
'X-RAY DIFFRACTION' 1.614 1.663  2346 . 118 2228 100.0000 . 0.258 . . 0.258 . . . . . 0.233 . 20 . 0.951 0.952 0.252 
'X-RAY DIFFRACTION' 1.663 1.717  2287 . 120 2167 100.0000 . 0.225 . . 0.224 . . . . . 0.195 . 20 . 0.964 0.957 0.248 
'X-RAY DIFFRACTION' 1.717 1.777  2221 . 137 2084 100.0000 . 0.211 . . 0.208 . . . . . 0.180 . 20 . 0.969 0.956 0.261 
'X-RAY DIFFRACTION' 1.777 1.844  2148 . 94  2053 99.9534  . 0.185 . . 0.182 . . . . . 0.156 . 20 . 0.978 0.960 0.244 
'X-RAY DIFFRACTION' 1.844 1.919  2075 . 104 1971 100.0000 . 0.169 . . 0.167 . . . . . 0.143 . 20 . 0.981 0.969 0.199 
'X-RAY DIFFRACTION' 1.919 2.003  1970 . 120 1850 100.0000 . 0.151 . . 0.150 . . . . . 0.129 . 20 . 0.985 0.982 0.176 
'X-RAY DIFFRACTION' 2.003 2.100  1909 . 100 1809 100.0000 . 0.165 . . 0.162 . . . . . 0.141 . 20 . 0.984 0.973 0.209 
'X-RAY DIFFRACTION' 2.100 2.213  1814 . 96  1718 100.0000 . 0.170 . . 0.168 . . . . . 0.148 . 20 . 0.982 0.975 0.199 
'X-RAY DIFFRACTION' 2.213 2.346  1711 . 72  1639 100.0000 . 0.169 . . 0.167 . . . . . 0.149 . 20 . 0.982 0.970 0.226 
'X-RAY DIFFRACTION' 2.346 2.506  1625 . 70  1555 100.0000 . 0.164 . . 0.163 . . . . . 0.148 . 20 . 0.984 0.981 0.183 
'X-RAY DIFFRACTION' 2.506 2.704  1525 . 72  1453 100.0000 . 0.176 . . 0.174 . . . . . 0.161 . 20 . 0.981 0.974 0.209 
'X-RAY DIFFRACTION' 2.704 2.958  1403 . 83  1320 100.0000 . 0.184 . . 0.181 . . . . . 0.173 . 20 . 0.979 0.960 0.245 
'X-RAY DIFFRACTION' 2.958 3.301  1272 . 60  1212 100.0000 . 0.175 . . 0.171 . . . . . 0.172 . 20 . 0.981 0.962 0.255 
'X-RAY DIFFRACTION' 3.301 3.798  1147 . 57  1087 99.7384  . 0.154 . . 0.152 . . . . . 0.156 . 20 . 0.985 0.982 0.184 
'X-RAY DIFFRACTION' 3.798 4.621  984  . 50  931  99.6951  . 0.154 . . 0.152 . . . . . 0.168 . 20 . 0.986 0.983 0.185 
'X-RAY DIFFRACTION' 4.621 6.407  792  . 29  761  99.7475  . 0.190 . . 0.187 . . . . . 0.204 . 20 . 0.982 0.970 0.285 
'X-RAY DIFFRACTION' 6.407 23.078 497  . 27  469  99.7988  . 0.187 . . 0.187 . . . . . 0.220 . 20 . 0.976 0.988 0.183 
# 
_struct.entry_id                     9AWZ 
_struct.title                        'Crystal structure of trypsin at 300 Kelvin with benzamidine (triplicate)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9AWZ 
_struct_keywords.text            'Inhibitor, Benzamidine, Complex, x-ray., HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    TRY1_BOVIN 
_struct_ref.pdbx_db_accession          P00760 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNT
LNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNM
FCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN
;
_struct_ref.pdbx_align_begin           24 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9AWZ 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 223 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P00760 
_struct_ref_seq.db_align_beg                  24 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  246 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       223 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 ALA A 38  ? TYR A 42  ? ALA A 38  TYR A 42  5 ? 5  
HELX_P HELX_P2 AA2 SER A 144 ? TYR A 152 ? SER A 144 TYR A 152 1 ? 9  
HELX_P HELX_P3 AA3 TYR A 212 ? ALA A 221 ? TYR A 212 ALA A 221 1 ? 10 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 7   SG  ? ? ? 1_555 A CYS 137 SG ? ? A CYS 7   A CYS 137 1_555 ? ? ? ? ? ? ? 2.013 ? ? 
disulf2 disulf ? ? A CYS 25  SG  ? ? ? 1_555 A CYS 41  SG ? ? A CYS 25  A CYS 41  1_555 ? ? ? ? ? ? ? 2.051 ? ? 
disulf3 disulf ? ? A CYS 109 SG  ? ? ? 1_555 A CYS 210 SG ? ? A CYS 109 A CYS 210 1_555 ? ? ? ? ? ? ? 2.042 ? ? 
disulf4 disulf ? ? A CYS 116 SG  ? ? ? 1_555 A CYS 183 SG ? ? A CYS 116 A CYS 183 1_555 ? ? ? ? ? ? ? 2.059 ? ? 
disulf5 disulf ? ? A CYS 148 SG  ? ? ? 1_555 A CYS 162 SG ? ? A CYS 148 A CYS 162 1_555 ? ? ? ? ? ? ? 1.960 ? ? 
disulf6 disulf ? ? A CYS 173 SG  ? ? ? 1_555 A CYS 197 SG ? ? A CYS 173 A CYS 197 1_555 ? ? ? ? ? ? ? 2.072 ? ? 
metalc1 metalc ? ? A GLU 52  OE1 ? ? ? 1_555 B CA  .   CA ? ? A GLU 52  A CA  301 1_555 ? ? ? ? ? ? ? 2.202 ? ? 
metalc2 metalc ? ? A ASN 54  O   ? ? ? 1_555 B CA  .   CA ? ? A ASN 54  A CA  301 1_555 ? ? ? ? ? ? ? 2.341 ? ? 
metalc3 metalc ? ? A VAL 57  O   ? ? ? 1_555 B CA  .   CA ? ? A VAL 57  A CA  301 1_555 ? ? ? ? ? ? ? 2.292 ? ? 
metalc4 metalc ? ? A GLU 59  OE1 ? ? ? 1_555 B CA  .   CA ? ? A GLU 59  A CA  301 1_555 ? ? ? ? ? ? ? 2.338 ? ? 
metalc5 metalc ? ? A GLU 62  OE2 ? ? ? 1_555 B CA  .   CA ? ? A GLU 62  A CA  301 1_555 ? ? ? ? ? ? ? 2.262 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OE1 ? A GLU 52 ? A GLU 52 ? 1_555 CA ? B CA . ? A CA 301 ? 1_555 O   ? A ASN 54 ? A ASN 54 ? 1_555 87.9  ? 
2  OE1 ? A GLU 52 ? A GLU 52 ? 1_555 CA ? B CA . ? A CA 301 ? 1_555 O   ? A VAL 57 ? A VAL 57 ? 1_555 159.9 ? 
3  O   ? A ASN 54 ? A ASN 54 ? 1_555 CA ? B CA . ? A CA 301 ? 1_555 O   ? A VAL 57 ? A VAL 57 ? 1_555 81.9  ? 
4  OE1 ? A GLU 52 ? A GLU 52 ? 1_555 CA ? B CA . ? A CA 301 ? 1_555 OE1 ? A GLU 59 ? A GLU 59 ? 1_555 95.1  ? 
5  O   ? A ASN 54 ? A ASN 54 ? 1_555 CA ? B CA . ? A CA 301 ? 1_555 OE1 ? A GLU 59 ? A GLU 59 ? 1_555 84.4  ? 
6  O   ? A VAL 57 ? A VAL 57 ? 1_555 CA ? B CA . ? A CA 301 ? 1_555 OE1 ? A GLU 59 ? A GLU 59 ? 1_555 101.0 ? 
7  OE1 ? A GLU 52 ? A GLU 52 ? 1_555 CA ? B CA . ? A CA 301 ? 1_555 OE2 ? A GLU 62 ? A GLU 62 ? 1_555 100.1 ? 
8  O   ? A ASN 54 ? A ASN 54 ? 1_555 CA ? B CA . ? A CA 301 ? 1_555 OE2 ? A GLU 62 ? A GLU 62 ? 1_555 166.0 ? 
9  O   ? A VAL 57 ? A VAL 57 ? 1_555 CA ? B CA . ? A CA 301 ? 1_555 OE2 ? A GLU 62 ? A GLU 62 ? 1_555 93.6  ? 
10 OE1 ? A GLU 59 ? A GLU 59 ? 1_555 CA ? B CA . ? A CA 301 ? 1_555 OE2 ? A GLU 62 ? A GLU 62 ? 1_555 83.5  ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 7   ? CYS A 137 ? CYS A 7   ? 1_555 CYS A 137 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 25  ? CYS A 41  ? CYS A 25  ? 1_555 CYS A 41  ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS A 109 ? CYS A 210 ? CYS A 109 ? 1_555 CYS A 210 ? 1_555 SG SG . . . None 'Disulfide bridge' 
4 CYS A 116 ? CYS A 183 ? CYS A 116 ? 1_555 CYS A 183 ? 1_555 SG SG . . . None 'Disulfide bridge' 
5 CYS A 148 ? CYS A 162 ? CYS A 148 ? 1_555 CYS A 162 ? 1_555 SG SG . . . None 'Disulfide bridge' 
6 CYS A 173 ? CYS A 197 ? CYS A 173 ? 1_555 CYS A 197 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 7 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
AA2 6 7 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 TYR A 5   ? THR A 6   ? TYR A 5   THR A 6   
AA1 2 LYS A 136 ? PRO A 141 ? LYS A 136 PRO A 141 
AA1 3 GLN A 115 ? GLY A 120 ? GLN A 115 GLY A 120 
AA1 4 PRO A 180 ? CYS A 183 ? PRO A 180 CYS A 183 
AA1 5 LYS A 186 ? TRP A 193 ? LYS A 186 TRP A 193 
AA1 6 GLY A 204 ? LYS A 208 ? GLY A 204 LYS A 208 
AA1 7 MET A 160 ? ALA A 163 ? MET A 160 ALA A 163 
AA2 1 GLN A 15  ? ASN A 19  ? GLN A 15  ASN A 19  
AA2 2 HIS A 23  ? ASN A 31  ? HIS A 23  ASN A 31  
AA2 3 TRP A 34  ? SER A 37  ? TRP A 34  SER A 37  
AA2 4 MET A 86  ? LEU A 90  ? MET A 86  LEU A 90  
AA2 5 GLN A 63  ? VAL A 72  ? GLN A 63  VAL A 72  
AA2 6 GLN A 47  ? LEU A 50  ? GLN A 47  LEU A 50  
AA2 7 GLN A 15  ? ASN A 19  ? GLN A 15  ASN A 19  
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N TYR A 5   ? N TYR A 5   O CYS A 137 ? O CYS A 137 
AA1 2 3 O LEU A 138 ? O LEU A 138 N ILE A 118 ? N ILE A 118 
AA1 3 4 N LEU A 117 ? N LEU A 117 O VAL A 182 ? O VAL A 182 
AA1 4 5 N CYS A 183 ? N CYS A 183 O LYS A 186 ? O LYS A 186 
AA1 5 6 N TRP A 193 ? N TRP A 193 O VAL A 205 ? O VAL A 205 
AA1 6 7 O TYR A 206 ? O TYR A 206 N PHE A 161 ? N PHE A 161 
AA2 1 2 N LEU A 18  ? N LEU A 18  O CYS A 25  ? O CYS A 25  
AA2 2 3 N SER A 28  ? N SER A 28  O VAL A 36  ? O VAL A 36  
AA2 3 4 N VAL A 35  ? N VAL A 35  O ILE A 88  ? O ILE A 88  
AA2 4 5 O LEU A 87  ? O LEU A 87  N ILE A 71  ? N ILE A 71  
AA2 5 6 O ILE A 65  ? O ILE A 65  N VAL A 48  ? N VAL A 48  
AA2 6 7 O ARG A 49  ? O ARG A 49  N SER A 17  ? N SER A 17  
# 
_pdbx_entry_details.entry_id                   9AWZ 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   O 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   HOH 
_pdbx_validate_close_contact.auth_seq_id_1    455 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   HOH 
_pdbx_validate_close_contact.auth_seq_id_2    473 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.19 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             NE 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_1              49 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CZ 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_2              49 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             NH1 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_3              49 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                117.27 
_pdbx_validate_rmsd_angle.angle_target_value         120.30 
_pdbx_validate_rmsd_angle.angle_deviation            -3.03 
_pdbx_validate_rmsd_angle.angle_standard_deviation   0.50 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 53  ? ? -118.67 -70.22 
2 1 SER A 177 ? ? -39.91  138.19 
3 1 SER A 192 ? ? -120.38 -67.57 
# 
_pdbx_validate_planes.id              1 
_pdbx_validate_planes.PDB_model_num   1 
_pdbx_validate_planes.auth_comp_id    ARG 
_pdbx_validate_planes.auth_asym_id    A 
_pdbx_validate_planes.auth_seq_id     49 
_pdbx_validate_planes.PDB_ins_code    ? 
_pdbx_validate_planes.label_alt_id    ? 
_pdbx_validate_planes.rmsd            0.086 
_pdbx_validate_planes.type            'SIDE CHAIN' 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
BEN C1   C  Y N 74  
BEN C2   C  Y N 75  
BEN C3   C  Y N 76  
BEN C4   C  Y N 77  
BEN C5   C  Y N 78  
BEN C6   C  Y N 79  
BEN C    C  N N 80  
BEN N1   N  N N 81  
BEN N2   N  N N 82  
BEN H2   H  N N 83  
BEN H3   H  N N 84  
BEN H4   H  N N 85  
BEN H5   H  N N 86  
BEN H6   H  N N 87  
BEN HN1  H  N N 88  
BEN HN21 H  N N 89  
BEN HN22 H  N N 90  
CA  CA   CA N N 91  
CYS N    N  N N 92  
CYS CA   C  N R 93  
CYS C    C  N N 94  
CYS O    O  N N 95  
CYS CB   C  N N 96  
CYS SG   S  N N 97  
CYS OXT  O  N N 98  
CYS H    H  N N 99  
CYS H2   H  N N 100 
CYS HA   H  N N 101 
CYS HB2  H  N N 102 
CYS HB3  H  N N 103 
CYS HG   H  N N 104 
CYS HXT  H  N N 105 
GLN N    N  N N 106 
GLN CA   C  N S 107 
GLN C    C  N N 108 
GLN O    O  N N 109 
GLN CB   C  N N 110 
GLN CG   C  N N 111 
GLN CD   C  N N 112 
GLN OE1  O  N N 113 
GLN NE2  N  N N 114 
GLN OXT  O  N N 115 
GLN H    H  N N 116 
GLN H2   H  N N 117 
GLN HA   H  N N 118 
GLN HB2  H  N N 119 
GLN HB3  H  N N 120 
GLN HG2  H  N N 121 
GLN HG3  H  N N 122 
GLN HE21 H  N N 123 
GLN HE22 H  N N 124 
GLN HXT  H  N N 125 
GLU N    N  N N 126 
GLU CA   C  N S 127 
GLU C    C  N N 128 
GLU O    O  N N 129 
GLU CB   C  N N 130 
GLU CG   C  N N 131 
GLU CD   C  N N 132 
GLU OE1  O  N N 133 
GLU OE2  O  N N 134 
GLU OXT  O  N N 135 
GLU H    H  N N 136 
GLU H2   H  N N 137 
GLU HA   H  N N 138 
GLU HB2  H  N N 139 
GLU HB3  H  N N 140 
GLU HG2  H  N N 141 
GLU HG3  H  N N 142 
GLU HE2  H  N N 143 
GLU HXT  H  N N 144 
GLY N    N  N N 145 
GLY CA   C  N N 146 
GLY C    C  N N 147 
GLY O    O  N N 148 
GLY OXT  O  N N 149 
GLY H    H  N N 150 
GLY H2   H  N N 151 
GLY HA2  H  N N 152 
GLY HA3  H  N N 153 
GLY HXT  H  N N 154 
HIS N    N  N N 155 
HIS CA   C  N S 156 
HIS C    C  N N 157 
HIS O    O  N N 158 
HIS CB   C  N N 159 
HIS CG   C  Y N 160 
HIS ND1  N  Y N 161 
HIS CD2  C  Y N 162 
HIS CE1  C  Y N 163 
HIS NE2  N  Y N 164 
HIS OXT  O  N N 165 
HIS H    H  N N 166 
HIS H2   H  N N 167 
HIS HA   H  N N 168 
HIS HB2  H  N N 169 
HIS HB3  H  N N 170 
HIS HD1  H  N N 171 
HIS HD2  H  N N 172 
HIS HE1  H  N N 173 
HIS HE2  H  N N 174 
HIS HXT  H  N N 175 
HOH O    O  N N 176 
HOH H1   H  N N 177 
HOH H2   H  N N 178 
ILE N    N  N N 179 
ILE CA   C  N S 180 
ILE C    C  N N 181 
ILE O    O  N N 182 
ILE CB   C  N S 183 
ILE CG1  C  N N 184 
ILE CG2  C  N N 185 
ILE CD1  C  N N 186 
ILE OXT  O  N N 187 
ILE H    H  N N 188 
ILE H2   H  N N 189 
ILE HA   H  N N 190 
ILE HB   H  N N 191 
ILE HG12 H  N N 192 
ILE HG13 H  N N 193 
ILE HG21 H  N N 194 
ILE HG22 H  N N 195 
ILE HG23 H  N N 196 
ILE HD11 H  N N 197 
ILE HD12 H  N N 198 
ILE HD13 H  N N 199 
ILE HXT  H  N N 200 
LEU N    N  N N 201 
LEU CA   C  N S 202 
LEU C    C  N N 203 
LEU O    O  N N 204 
LEU CB   C  N N 205 
LEU CG   C  N N 206 
LEU CD1  C  N N 207 
LEU CD2  C  N N 208 
LEU OXT  O  N N 209 
LEU H    H  N N 210 
LEU H2   H  N N 211 
LEU HA   H  N N 212 
LEU HB2  H  N N 213 
LEU HB3  H  N N 214 
LEU HG   H  N N 215 
LEU HD11 H  N N 216 
LEU HD12 H  N N 217 
LEU HD13 H  N N 218 
LEU HD21 H  N N 219 
LEU HD22 H  N N 220 
LEU HD23 H  N N 221 
LEU HXT  H  N N 222 
LYS N    N  N N 223 
LYS CA   C  N S 224 
LYS C    C  N N 225 
LYS O    O  N N 226 
LYS CB   C  N N 227 
LYS CG   C  N N 228 
LYS CD   C  N N 229 
LYS CE   C  N N 230 
LYS NZ   N  N N 231 
LYS OXT  O  N N 232 
LYS H    H  N N 233 
LYS H2   H  N N 234 
LYS HA   H  N N 235 
LYS HB2  H  N N 236 
LYS HB3  H  N N 237 
LYS HG2  H  N N 238 
LYS HG3  H  N N 239 
LYS HD2  H  N N 240 
LYS HD3  H  N N 241 
LYS HE2  H  N N 242 
LYS HE3  H  N N 243 
LYS HZ1  H  N N 244 
LYS HZ2  H  N N 245 
LYS HZ3  H  N N 246 
LYS HXT  H  N N 247 
MET N    N  N N 248 
MET CA   C  N S 249 
MET C    C  N N 250 
MET O    O  N N 251 
MET CB   C  N N 252 
MET CG   C  N N 253 
MET SD   S  N N 254 
MET CE   C  N N 255 
MET OXT  O  N N 256 
MET H    H  N N 257 
MET H2   H  N N 258 
MET HA   H  N N 259 
MET HB2  H  N N 260 
MET HB3  H  N N 261 
MET HG2  H  N N 262 
MET HG3  H  N N 263 
MET HE1  H  N N 264 
MET HE2  H  N N 265 
MET HE3  H  N N 266 
MET HXT  H  N N 267 
PHE N    N  N N 268 
PHE CA   C  N S 269 
PHE C    C  N N 270 
PHE O    O  N N 271 
PHE CB   C  N N 272 
PHE CG   C  Y N 273 
PHE CD1  C  Y N 274 
PHE CD2  C  Y N 275 
PHE CE1  C  Y N 276 
PHE CE2  C  Y N 277 
PHE CZ   C  Y N 278 
PHE OXT  O  N N 279 
PHE H    H  N N 280 
PHE H2   H  N N 281 
PHE HA   H  N N 282 
PHE HB2  H  N N 283 
PHE HB3  H  N N 284 
PHE HD1  H  N N 285 
PHE HD2  H  N N 286 
PHE HE1  H  N N 287 
PHE HE2  H  N N 288 
PHE HZ   H  N N 289 
PHE HXT  H  N N 290 
PRO N    N  N N 291 
PRO CA   C  N S 292 
PRO C    C  N N 293 
PRO O    O  N N 294 
PRO CB   C  N N 295 
PRO CG   C  N N 296 
PRO CD   C  N N 297 
PRO OXT  O  N N 298 
PRO H    H  N N 299 
PRO HA   H  N N 300 
PRO HB2  H  N N 301 
PRO HB3  H  N N 302 
PRO HG2  H  N N 303 
PRO HG3  H  N N 304 
PRO HD2  H  N N 305 
PRO HD3  H  N N 306 
PRO HXT  H  N N 307 
SER N    N  N N 308 
SER CA   C  N S 309 
SER C    C  N N 310 
SER O    O  N N 311 
SER CB   C  N N 312 
SER OG   O  N N 313 
SER OXT  O  N N 314 
SER H    H  N N 315 
SER H2   H  N N 316 
SER HA   H  N N 317 
SER HB2  H  N N 318 
SER HB3  H  N N 319 
SER HG   H  N N 320 
SER HXT  H  N N 321 
THR N    N  N N 322 
THR CA   C  N S 323 
THR C    C  N N 324 
THR O    O  N N 325 
THR CB   C  N R 326 
THR OG1  O  N N 327 
THR CG2  C  N N 328 
THR OXT  O  N N 329 
THR H    H  N N 330 
THR H2   H  N N 331 
THR HA   H  N N 332 
THR HB   H  N N 333 
THR HG1  H  N N 334 
THR HG21 H  N N 335 
THR HG22 H  N N 336 
THR HG23 H  N N 337 
THR HXT  H  N N 338 
TRP N    N  N N 339 
TRP CA   C  N S 340 
TRP C    C  N N 341 
TRP O    O  N N 342 
TRP CB   C  N N 343 
TRP CG   C  Y N 344 
TRP CD1  C  Y N 345 
TRP CD2  C  Y N 346 
TRP NE1  N  Y N 347 
TRP CE2  C  Y N 348 
TRP CE3  C  Y N 349 
TRP CZ2  C  Y N 350 
TRP CZ3  C  Y N 351 
TRP CH2  C  Y N 352 
TRP OXT  O  N N 353 
TRP H    H  N N 354 
TRP H2   H  N N 355 
TRP HA   H  N N 356 
TRP HB2  H  N N 357 
TRP HB3  H  N N 358 
TRP HD1  H  N N 359 
TRP HE1  H  N N 360 
TRP HE3  H  N N 361 
TRP HZ2  H  N N 362 
TRP HZ3  H  N N 363 
TRP HH2  H  N N 364 
TRP HXT  H  N N 365 
TYR N    N  N N 366 
TYR CA   C  N S 367 
TYR C    C  N N 368 
TYR O    O  N N 369 
TYR CB   C  N N 370 
TYR CG   C  Y N 371 
TYR CD1  C  Y N 372 
TYR CD2  C  Y N 373 
TYR CE1  C  Y N 374 
TYR CE2  C  Y N 375 
TYR CZ   C  Y N 376 
TYR OH   O  N N 377 
TYR OXT  O  N N 378 
TYR H    H  N N 379 
TYR H2   H  N N 380 
TYR HA   H  N N 381 
TYR HB2  H  N N 382 
TYR HB3  H  N N 383 
TYR HD1  H  N N 384 
TYR HD2  H  N N 385 
TYR HE1  H  N N 386 
TYR HE2  H  N N 387 
TYR HH   H  N N 388 
TYR HXT  H  N N 389 
VAL N    N  N N 390 
VAL CA   C  N S 391 
VAL C    C  N N 392 
VAL O    O  N N 393 
VAL CB   C  N N 394 
VAL CG1  C  N N 395 
VAL CG2  C  N N 396 
VAL OXT  O  N N 397 
VAL H    H  N N 398 
VAL H2   H  N N 399 
VAL HA   H  N N 400 
VAL HB   H  N N 401 
VAL HG11 H  N N 402 
VAL HG12 H  N N 403 
VAL HG13 H  N N 404 
VAL HG21 H  N N 405 
VAL HG22 H  N N 406 
VAL HG23 H  N N 407 
VAL HXT  H  N N 408 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
BEN C1  C2   doub Y N 70  
BEN C1  C6   sing Y N 71  
BEN C1  C    sing N N 72  
BEN C2  C3   sing Y N 73  
BEN C2  H2   sing N N 74  
BEN C3  C4   doub Y N 75  
BEN C3  H3   sing N N 76  
BEN C4  C5   sing Y N 77  
BEN C4  H4   sing N N 78  
BEN C5  C6   doub Y N 79  
BEN C5  H5   sing N N 80  
BEN C6  H6   sing N N 81  
BEN C   N1   doub N E 82  
BEN C   N2   sing N N 83  
BEN N1  HN1  sing N N 84  
BEN N2  HN21 sing N N 85  
BEN N2  HN22 sing N N 86  
CYS N   CA   sing N N 87  
CYS N   H    sing N N 88  
CYS N   H2   sing N N 89  
CYS CA  C    sing N N 90  
CYS CA  CB   sing N N 91  
CYS CA  HA   sing N N 92  
CYS C   O    doub N N 93  
CYS C   OXT  sing N N 94  
CYS CB  SG   sing N N 95  
CYS CB  HB2  sing N N 96  
CYS CB  HB3  sing N N 97  
CYS SG  HG   sing N N 98  
CYS OXT HXT  sing N N 99  
GLN N   CA   sing N N 100 
GLN N   H    sing N N 101 
GLN N   H2   sing N N 102 
GLN CA  C    sing N N 103 
GLN CA  CB   sing N N 104 
GLN CA  HA   sing N N 105 
GLN C   O    doub N N 106 
GLN C   OXT  sing N N 107 
GLN CB  CG   sing N N 108 
GLN CB  HB2  sing N N 109 
GLN CB  HB3  sing N N 110 
GLN CG  CD   sing N N 111 
GLN CG  HG2  sing N N 112 
GLN CG  HG3  sing N N 113 
GLN CD  OE1  doub N N 114 
GLN CD  NE2  sing N N 115 
GLN NE2 HE21 sing N N 116 
GLN NE2 HE22 sing N N 117 
GLN OXT HXT  sing N N 118 
GLU N   CA   sing N N 119 
GLU N   H    sing N N 120 
GLU N   H2   sing N N 121 
GLU CA  C    sing N N 122 
GLU CA  CB   sing N N 123 
GLU CA  HA   sing N N 124 
GLU C   O    doub N N 125 
GLU C   OXT  sing N N 126 
GLU CB  CG   sing N N 127 
GLU CB  HB2  sing N N 128 
GLU CB  HB3  sing N N 129 
GLU CG  CD   sing N N 130 
GLU CG  HG2  sing N N 131 
GLU CG  HG3  sing N N 132 
GLU CD  OE1  doub N N 133 
GLU CD  OE2  sing N N 134 
GLU OE2 HE2  sing N N 135 
GLU OXT HXT  sing N N 136 
GLY N   CA   sing N N 137 
GLY N   H    sing N N 138 
GLY N   H2   sing N N 139 
GLY CA  C    sing N N 140 
GLY CA  HA2  sing N N 141 
GLY CA  HA3  sing N N 142 
GLY C   O    doub N N 143 
GLY C   OXT  sing N N 144 
GLY OXT HXT  sing N N 145 
HIS N   CA   sing N N 146 
HIS N   H    sing N N 147 
HIS N   H2   sing N N 148 
HIS CA  C    sing N N 149 
HIS CA  CB   sing N N 150 
HIS CA  HA   sing N N 151 
HIS C   O    doub N N 152 
HIS C   OXT  sing N N 153 
HIS CB  CG   sing N N 154 
HIS CB  HB2  sing N N 155 
HIS CB  HB3  sing N N 156 
HIS CG  ND1  sing Y N 157 
HIS CG  CD2  doub Y N 158 
HIS ND1 CE1  doub Y N 159 
HIS ND1 HD1  sing N N 160 
HIS CD2 NE2  sing Y N 161 
HIS CD2 HD2  sing N N 162 
HIS CE1 NE2  sing Y N 163 
HIS CE1 HE1  sing N N 164 
HIS NE2 HE2  sing N N 165 
HIS OXT HXT  sing N N 166 
HOH O   H1   sing N N 167 
HOH O   H2   sing N N 168 
ILE N   CA   sing N N 169 
ILE N   H    sing N N 170 
ILE N   H2   sing N N 171 
ILE CA  C    sing N N 172 
ILE CA  CB   sing N N 173 
ILE CA  HA   sing N N 174 
ILE C   O    doub N N 175 
ILE C   OXT  sing N N 176 
ILE CB  CG1  sing N N 177 
ILE CB  CG2  sing N N 178 
ILE CB  HB   sing N N 179 
ILE CG1 CD1  sing N N 180 
ILE CG1 HG12 sing N N 181 
ILE CG1 HG13 sing N N 182 
ILE CG2 HG21 sing N N 183 
ILE CG2 HG22 sing N N 184 
ILE CG2 HG23 sing N N 185 
ILE CD1 HD11 sing N N 186 
ILE CD1 HD12 sing N N 187 
ILE CD1 HD13 sing N N 188 
ILE OXT HXT  sing N N 189 
LEU N   CA   sing N N 190 
LEU N   H    sing N N 191 
LEU N   H2   sing N N 192 
LEU CA  C    sing N N 193 
LEU CA  CB   sing N N 194 
LEU CA  HA   sing N N 195 
LEU C   O    doub N N 196 
LEU C   OXT  sing N N 197 
LEU CB  CG   sing N N 198 
LEU CB  HB2  sing N N 199 
LEU CB  HB3  sing N N 200 
LEU CG  CD1  sing N N 201 
LEU CG  CD2  sing N N 202 
LEU CG  HG   sing N N 203 
LEU CD1 HD11 sing N N 204 
LEU CD1 HD12 sing N N 205 
LEU CD1 HD13 sing N N 206 
LEU CD2 HD21 sing N N 207 
LEU CD2 HD22 sing N N 208 
LEU CD2 HD23 sing N N 209 
LEU OXT HXT  sing N N 210 
LYS N   CA   sing N N 211 
LYS N   H    sing N N 212 
LYS N   H2   sing N N 213 
LYS CA  C    sing N N 214 
LYS CA  CB   sing N N 215 
LYS CA  HA   sing N N 216 
LYS C   O    doub N N 217 
LYS C   OXT  sing N N 218 
LYS CB  CG   sing N N 219 
LYS CB  HB2  sing N N 220 
LYS CB  HB3  sing N N 221 
LYS CG  CD   sing N N 222 
LYS CG  HG2  sing N N 223 
LYS CG  HG3  sing N N 224 
LYS CD  CE   sing N N 225 
LYS CD  HD2  sing N N 226 
LYS CD  HD3  sing N N 227 
LYS CE  NZ   sing N N 228 
LYS CE  HE2  sing N N 229 
LYS CE  HE3  sing N N 230 
LYS NZ  HZ1  sing N N 231 
LYS NZ  HZ2  sing N N 232 
LYS NZ  HZ3  sing N N 233 
LYS OXT HXT  sing N N 234 
MET N   CA   sing N N 235 
MET N   H    sing N N 236 
MET N   H2   sing N N 237 
MET CA  C    sing N N 238 
MET CA  CB   sing N N 239 
MET CA  HA   sing N N 240 
MET C   O    doub N N 241 
MET C   OXT  sing N N 242 
MET CB  CG   sing N N 243 
MET CB  HB2  sing N N 244 
MET CB  HB3  sing N N 245 
MET CG  SD   sing N N 246 
MET CG  HG2  sing N N 247 
MET CG  HG3  sing N N 248 
MET SD  CE   sing N N 249 
MET CE  HE1  sing N N 250 
MET CE  HE2  sing N N 251 
MET CE  HE3  sing N N 252 
MET OXT HXT  sing N N 253 
PHE N   CA   sing N N 254 
PHE N   H    sing N N 255 
PHE N   H2   sing N N 256 
PHE CA  C    sing N N 257 
PHE CA  CB   sing N N 258 
PHE CA  HA   sing N N 259 
PHE C   O    doub N N 260 
PHE C   OXT  sing N N 261 
PHE CB  CG   sing N N 262 
PHE CB  HB2  sing N N 263 
PHE CB  HB3  sing N N 264 
PHE CG  CD1  doub Y N 265 
PHE CG  CD2  sing Y N 266 
PHE CD1 CE1  sing Y N 267 
PHE CD1 HD1  sing N N 268 
PHE CD2 CE2  doub Y N 269 
PHE CD2 HD2  sing N N 270 
PHE CE1 CZ   doub Y N 271 
PHE CE1 HE1  sing N N 272 
PHE CE2 CZ   sing Y N 273 
PHE CE2 HE2  sing N N 274 
PHE CZ  HZ   sing N N 275 
PHE OXT HXT  sing N N 276 
PRO N   CA   sing N N 277 
PRO N   CD   sing N N 278 
PRO N   H    sing N N 279 
PRO CA  C    sing N N 280 
PRO CA  CB   sing N N 281 
PRO CA  HA   sing N N 282 
PRO C   O    doub N N 283 
PRO C   OXT  sing N N 284 
PRO CB  CG   sing N N 285 
PRO CB  HB2  sing N N 286 
PRO CB  HB3  sing N N 287 
PRO CG  CD   sing N N 288 
PRO CG  HG2  sing N N 289 
PRO CG  HG3  sing N N 290 
PRO CD  HD2  sing N N 291 
PRO CD  HD3  sing N N 292 
PRO OXT HXT  sing N N 293 
SER N   CA   sing N N 294 
SER N   H    sing N N 295 
SER N   H2   sing N N 296 
SER CA  C    sing N N 297 
SER CA  CB   sing N N 298 
SER CA  HA   sing N N 299 
SER C   O    doub N N 300 
SER C   OXT  sing N N 301 
SER CB  OG   sing N N 302 
SER CB  HB2  sing N N 303 
SER CB  HB3  sing N N 304 
SER OG  HG   sing N N 305 
SER OXT HXT  sing N N 306 
THR N   CA   sing N N 307 
THR N   H    sing N N 308 
THR N   H2   sing N N 309 
THR CA  C    sing N N 310 
THR CA  CB   sing N N 311 
THR CA  HA   sing N N 312 
THR C   O    doub N N 313 
THR C   OXT  sing N N 314 
THR CB  OG1  sing N N 315 
THR CB  CG2  sing N N 316 
THR CB  HB   sing N N 317 
THR OG1 HG1  sing N N 318 
THR CG2 HG21 sing N N 319 
THR CG2 HG22 sing N N 320 
THR CG2 HG23 sing N N 321 
THR OXT HXT  sing N N 322 
TRP N   CA   sing N N 323 
TRP N   H    sing N N 324 
TRP N   H2   sing N N 325 
TRP CA  C    sing N N 326 
TRP CA  CB   sing N N 327 
TRP CA  HA   sing N N 328 
TRP C   O    doub N N 329 
TRP C   OXT  sing N N 330 
TRP CB  CG   sing N N 331 
TRP CB  HB2  sing N N 332 
TRP CB  HB3  sing N N 333 
TRP CG  CD1  doub Y N 334 
TRP CG  CD2  sing Y N 335 
TRP CD1 NE1  sing Y N 336 
TRP CD1 HD1  sing N N 337 
TRP CD2 CE2  doub Y N 338 
TRP CD2 CE3  sing Y N 339 
TRP NE1 CE2  sing Y N 340 
TRP NE1 HE1  sing N N 341 
TRP CE2 CZ2  sing Y N 342 
TRP CE3 CZ3  doub Y N 343 
TRP CE3 HE3  sing N N 344 
TRP CZ2 CH2  doub Y N 345 
TRP CZ2 HZ2  sing N N 346 
TRP CZ3 CH2  sing Y N 347 
TRP CZ3 HZ3  sing N N 348 
TRP CH2 HH2  sing N N 349 
TRP OXT HXT  sing N N 350 
TYR N   CA   sing N N 351 
TYR N   H    sing N N 352 
TYR N   H2   sing N N 353 
TYR CA  C    sing N N 354 
TYR CA  CB   sing N N 355 
TYR CA  HA   sing N N 356 
TYR C   O    doub N N 357 
TYR C   OXT  sing N N 358 
TYR CB  CG   sing N N 359 
TYR CB  HB2  sing N N 360 
TYR CB  HB3  sing N N 361 
TYR CG  CD1  doub Y N 362 
TYR CG  CD2  sing Y N 363 
TYR CD1 CE1  sing Y N 364 
TYR CD1 HD1  sing N N 365 
TYR CD2 CE2  doub Y N 366 
TYR CD2 HD2  sing N N 367 
TYR CE1 CZ   doub Y N 368 
TYR CE1 HE1  sing N N 369 
TYR CE2 CZ   sing Y N 370 
TYR CE2 HE2  sing N N 371 
TYR CZ  OH   sing N N 372 
TYR OH  HH   sing N N 373 
TYR OXT HXT  sing N N 374 
VAL N   CA   sing N N 375 
VAL N   H    sing N N 376 
VAL N   H2   sing N N 377 
VAL CA  C    sing N N 378 
VAL CA  CB   sing N N 379 
VAL CA  HA   sing N N 380 
VAL C   O    doub N N 381 
VAL C   OXT  sing N N 382 
VAL CB  CG1  sing N N 383 
VAL CB  CG2  sing N N 384 
VAL CB  HB   sing N N 385 
VAL CG1 HG11 sing N N 386 
VAL CG1 HG12 sing N N 387 
VAL CG1 HG13 sing N N 388 
VAL CG2 HG21 sing N N 389 
VAL CG2 HG22 sing N N 390 
VAL CG2 HG23 sing N N 391 
VAL OXT HXT  sing N N 392 
# 
_pdbx_audit_support.funding_organization   'Brazilian National Council for Scientific and Technological Development (CNPq)' 
_pdbx_audit_support.country                Brazil 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1s0r 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9AWZ 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.018407 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.017423 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.014851 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C  6  6  2.310  20.844 1.020 10.208 1.589 0.569  0.865 51.651  0.216   
CA 20 20 8.627  10.442 7.387 0.660  1.590 85.748 1.021 178.437 1.375   
H  1  1  0.493  10.511 0.323 26.126 0.140 3.142  0.041 57.800  0.003   
N  7  7  12.222 0.006  3.135 9.893  2.014 28.997 1.167 0.583   -11.538 
O  8  8  3.049  13.277 2.287 5.701  1.546 0.324  0.867 32.909  0.251   
S  16 16 6.905  1.468  5.203 22.215 1.438 0.254  1.586 56.172  0.867   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N  N   . ILE A 1 1   ? 8.269   -20.084 13.193  1.000 11.970 0 1   ILE A N   1 ? 
ATOM   2    C  CA  . ILE A 1 1   ? 8.294   -21.039 14.337  1.000 12.625 0 1   ILE A CA  1 ? 
ATOM   3    C  C   . ILE A 1 1   ? 9.563   -20.805 15.150  1.000 13.497 0 1   ILE A C   1 ? 
ATOM   4    O  O   . ILE A 1 1   ? 10.648  -20.895 14.577  1.000 14.670 0 1   ILE A O   1 ? 
ATOM   5    C  CB  . ILE A 1 1   ? 8.305   -22.468 13.775  1.000 13.682 0 1   ILE A CB  1 ? 
ATOM   6    C  CG1 . ILE A 1 1   ? 7.106   -22.861 12.906  1.000 14.756 0 1   ILE A CG1 1 ? 
ATOM   7    C  CG2 . ILE A 1 1   ? 8.446   -23.469 14.932  1.000 14.503 0 1   ILE A CG2 1 ? 
ATOM   8    C  CD1 . ILE A 1 1   ? 5.774   -22.773 13.597  1.000 15.368 0 1   ILE A CD1 1 ? 
ATOM   9    N  N   . VAL A 1 2   ? 9.396   -20.556 16.453  1.000 13.164 0 2   VAL A N   1 ? 
ATOM   10   C  CA  . VAL A 1 2   ? 10.530  -20.391 17.353  1.000 15.084 0 2   VAL A CA  1 ? 
ATOM   11   C  C   . VAL A 1 2   ? 10.725  -21.687 18.119  1.000 15.101 0 2   VAL A C   1 ? 
ATOM   12   O  O   . VAL A 1 2   ? 9.778   -22.210 18.706  1.000 16.052 0 2   VAL A O   1 ? 
ATOM   13   C  CB  . VAL A 1 2   ? 10.215  -19.244 18.329  1.000 16.334 0 2   VAL A CB  1 ? 
ATOM   14   C  CG1 . VAL A 1 2   ? 11.362  -19.048 19.333  1.000 18.648 0 2   VAL A CG1 1 ? 
ATOM   15   C  CG2 . VAL A 1 2   ? 9.856   -17.931 17.632  1.000 18.165 0 2   VAL A CG2 1 ? 
ATOM   16   N  N   . GLY A 1 3   ? 11.953  -22.225 18.101  1.000 15.404 0 3   GLY A N   1 ? 
ATOM   17   C  CA  . GLY A 1 3   ? 12.279  -23.356 18.967  1.000 16.641 0 3   GLY A CA  1 ? 
ATOM   18   C  C   . GLY A 1 3   ? 11.808  -24.685 18.397  1.000 18.170 0 3   GLY A C   1 ? 
ATOM   19   O  O   . GLY A 1 3   ? 11.620  -25.645 19.134  1.000 19.583 0 3   GLY A O   1 ? 
ATOM   20   N  N   . GLY A 1 4   ? 11.564  -24.731 17.095  1.000 18.198 0 4   GLY A N   1 ? 
ATOM   21   C  CA  . GLY A 1 4   ? 11.057  -25.928 16.449  1.000 17.327 0 4   GLY A CA  1 ? 
ATOM   22   C  C   . GLY A 1 4   ? 12.181  -26.678 15.763  1.000 18.095 0 4   GLY A C   1 ? 
ATOM   23   O  O   . GLY A 1 4   ? 13.340  -26.455 16.119  1.000 21.415 0 4   GLY A O   1 ? 
ATOM   24   N  N   . TYR A 1 5   ? 11.851  -27.485 14.755  1.000 15.561 0 5   TYR A N   1 ? 
ATOM   25   C  CA  . TYR A 1 5   ? 12.806  -28.310 14.066  1.000 17.580 0 5   TYR A CA  1 ? 
ATOM   26   C  C   . TYR A 1 5   ? 12.499  -28.252 12.579  1.000 15.622 0 5   TYR A C   1 ? 
ATOM   27   O  O   . TYR A 1 5   ? 11.375  -27.950 12.183  1.000 14.625 0 5   TYR A O   1 ? 
ATOM   28   C  CB  . TYR A 1 5   ? 12.789  -29.737 14.614  1.000 17.271 0 5   TYR A CB  1 ? 
ATOM   29   C  CG  . TYR A 1 5   ? 11.474  -30.470 14.495  1.000 17.350 0 5   TYR A CG  1 ? 
ATOM   30   C  CD1 . TYR A 1 5   ? 10.446  -30.213 15.397  1.000 16.612 0 5   TYR A CD1 1 ? 
ATOM   31   C  CD2 . TYR A 1 5   ? 11.243  -31.366 13.461  1.000 16.274 0 5   TYR A CD2 1 ? 
ATOM   32   C  CE1 . TYR A 1 5   ? 9.249   -30.896 15.329  1.000 17.030 0 5   TYR A CE1 1 ? 
ATOM   33   C  CE2 . TYR A 1 5   ? 10.047  -32.037 13.389  1.000 15.797 0 5   TYR A CE2 1 ? 
ATOM   34   C  CZ  . TYR A 1 5   ? 9.053   -31.782 14.301  1.000 16.708 0 5   TYR A CZ  1 ? 
ATOM   35   O  OH  . TYR A 1 5   ? 7.874   -32.443 14.215  1.000 18.404 0 5   TYR A OH  1 ? 
ATOM   36   N  N   . THR A 1 6   ? 13.475  -28.573 11.741  1.000 16.741 0 6   THR A N   1 ? 
ATOM   37   C  CA  . THR A 1 6   ? 13.246  -28.662 10.310  1.000 16.245 0 6   THR A CA  1 ? 
ATOM   38   C  C   . THR A 1 6   ? 12.373  -29.858 9.995   1.000 17.243 0 6   THR A C   1 ? 
ATOM   39   O  O   . THR A 1 6   ? 12.764  -30.972 10.323  1.000 20.264 0 6   THR A O   1 ? 
ATOM   40   C  CB  . THR A 1 6   ? 14.594  -28.773 9.593   1.000 20.089 0 6   THR A CB  1 ? 
ATOM   41   O  OG1 . THR A 1 6   ? 15.293  -27.585 9.912   1.000 22.045 0 6   THR A OG1 1 ? 
ATOM   42   C  CG2 . THR A 1 6   ? 14.451  -28.811 8.092   1.000 21.502 0 6   THR A CG2 1 ? 
ATOM   43   N  N   . CYS A 1 7   ? 11.168  -29.663 9.405   1.000 15.915 0 7   CYS A N   1 ? 
ATOM   44   C  CA  . CYS A 1 7   ? 10.239  -30.767 9.229   1.000 16.368 0 7   CYS A CA  1 ? 
ATOM   45   C  C   . CYS A 1 7   ? 10.833  -31.877 8.376   1.000 20.608 0 7   CYS A C   1 ? 
ATOM   46   O  O   . CYS A 1 7   ? 10.577  -33.069 8.609   1.000 21.677 0 7   CYS A O   1 ? 
ATOM   47   C  CB  . CYS A 1 7   ? 8.986   -30.266 8.521   1.000 15.425 0 7   CYS A CB  1 ? 
ATOM   48   S  SG  . CYS A 1 7   ? 8.198   -28.878 9.317   1.000 14.724 0 7   CYS A SG  1 ? 
ATOM   49   N  N   . GLY A 1 8   ? 11.568  -31.476 7.353   1.000 20.844 0 8   GLY A N   1 ? 
ATOM   50   C  CA  . GLY A 1 8   ? 11.963  -32.398 6.296   1.000 22.376 0 8   GLY A CA  1 ? 
ATOM   51   C  C   . GLY A 1 8   ? 11.039  -32.222 5.103   1.000 23.070 0 8   GLY A C   1 ? 
ATOM   52   O  O   . GLY A 1 8   ? 9.829   -32.035 5.261   1.000 23.164 0 8   GLY A O   1 ? 
ATOM   53   N  N   . ALA A 1 9   ? 11.617  -32.277 3.898   1.000 22.034 0 9   ALA A N   1 ? 
ATOM   54   C  CA  . ALA A 1 9   ? 10.900  -31.983 2.665   1.000 23.660 0 9   ALA A CA  1 ? 
ATOM   55   C  C   . ALA A 1 9   ? 9.627   -32.816 2.507   1.000 23.806 0 9   ALA A C   1 ? 
ATOM   56   O  O   . ALA A 1 9   ? 9.670   -34.038 2.505   1.000 24.873 0 9   ALA A O   1 ? 
ATOM   57   C  CB  . ALA A 1 9   ? 11.810  -32.209 1.475   1.000 24.950 0 9   ALA A CB  1 ? 
ATOM   58   N  N   . ASN A 1 10  ? 8.498   -32.123 2.355   1.000 26.393 0 10  ASN A N   1 ? 
ATOM   59   C  CA  . ASN A 1 10  ? 7.237   -32.746 1.994   1.000 26.102 0 10  ASN A CA  1 ? 
ATOM   60   C  C   . ASN A 1 10  ? 6.773   -33.763 3.052   1.000 23.891 0 10  ASN A C   1 ? 
ATOM   61   O  O   . ASN A 1 10  ? 6.011   -34.661 2.729   1.000 30.207 0 10  ASN A O   1 ? 
ATOM   62   C  CB  . ASN A 1 10  ? 7.316   -33.299 0.563   1.000 29.589 0 10  ASN A CB  1 ? 
ATOM   63   C  CG  . ASN A 1 10  ? 7.931   -32.341 -0.440  1.000 32.415 0 10  ASN A CG  1 ? 
ATOM   64   O  OD1 . ASN A 1 10  ? 9.018   -32.593 -0.978  1.000 33.679 0 10  ASN A OD1 1 ? 
ATOM   65   N  ND2 . ASN A 1 10  ? 7.263   -31.230 -0.710  1.000 33.639 0 10  ASN A ND2 1 ? 
ATOM   66   N  N   . THR A 1 11  ? 7.121   -33.585 4.348   1.000 21.035 0 11  THR A N   1 ? 
ATOM   67   C  CA  . THR A 1 11  ? 6.566   -34.379 5.432   1.000 19.320 0 11  THR A CA  1 ? 
ATOM   68   C  C   . THR A 1 11  ? 5.288   -33.741 5.993   1.000 19.368 0 11  THR A C   1 ? 
ATOM   69   O  O   . THR A 1 11  ? 4.631   -34.293 6.867   1.000 20.571 0 11  THR A O   1 ? 
ATOM   70   C  CB  . THR A 1 11  ? 7.604   -34.551 6.529   1.000 21.539 0 11  THR A CB  1 ? 
ATOM   71   O  OG1 . THR A 1 11  ? 7.903   -33.263 7.041   1.000 22.491 0 11  THR A OG1 1 ? 
ATOM   72   C  CG2 . THR A 1 11  ? 8.893   -35.185 6.036   1.000 22.684 0 11  THR A CG2 1 ? 
ATOM   73   N  N   . VAL A 1 12  ? 4.940   -32.537 5.480   1.000 17.590 0 12  VAL A N   1 ? 
ATOM   74   C  CA  . VAL A 1 12  ? 3.744   -31.796 5.856   1.000 14.538 0 12  VAL A CA  1 ? 
ATOM   75   C  C   . VAL A 1 12  ? 3.078   -31.425 4.546   1.000 14.832 0 12  VAL A C   1 ? 
ATOM   76   O  O   . VAL A 1 12  ? 3.125   -30.284 4.092   1.000 14.505 0 12  VAL A O   1 ? 
ATOM   77   C  CB  . VAL A 1 12  ? 4.051   -30.559 6.738   1.000 15.838 0 12  VAL A CB  1 ? 
ATOM   78   C  CG1 . VAL A 1 12  ? 2.812   -30.040 7.410   1.000 17.909 0 12  VAL A CG1 1 ? 
ATOM   79   C  CG2 . VAL A 1 12  ? 5.087   -30.886 7.789   1.000 18.103 0 12  VAL A CG2 1 ? 
ATOM   80   N  N   . PRO A 1 13  ? 2.464   -32.419 3.860   1.000 15.801 0 13  PRO A N   1 ? 
ATOM   81   C  CA  . PRO A 1 13  ? 2.072   -32.234 2.477   1.000 14.285 0 13  PRO A CA  1 ? 
ATOM   82   C  C   . PRO A 1 13  ? 0.847   -31.368 2.256   1.000 12.851 0 13  PRO A C   1 ? 
ATOM   83   O  O   . PRO A 1 13  ? 0.612   -30.955 1.146   1.000 13.109 0 13  PRO A O   1 ? 
ATOM   84   C  CB  . PRO A 1 13  ? 1.846   -33.669 1.993   1.000 15.311 0 13  PRO A CB  1 ? 
ATOM   85   C  CG  . PRO A 1 13  ? 1.434   -34.396 3.213   1.000 14.753 0 13  PRO A CG  1 ? 
ATOM   86   C  CD  . PRO A 1 13  ? 2.235   -33.799 4.325   1.000 15.672 0 13  PRO A CD  1 ? 
ATOM   87   N  N   . TYR A 1 14  ? 0.183   -30.994 3.334   1.000 12.271 0 14  TYR A N   1 ? 
ATOM   88   C  CA  . TYR A 1 14  ? -0.991  -30.144 3.298   1.000 12.031 0 14  TYR A CA  1 ? 
ATOM   89   C  C   . TYR A 1 14  ? -0.648  -28.677 3.559   1.000 12.237 0 14  TYR A C   1 ? 
ATOM   90   O  O   . TYR A 1 14  ? -1.499  -27.815 3.383   1.000 12.109 0 14  TYR A O   1 ? 
ATOM   91   C  CB  . TYR A 1 14  ? -2.047  -30.599 4.317   1.000 12.843 0 14  TYR A CB  1 ? 
ATOM   92   C  CG  . TYR A 1 14  ? -1.441  -30.807 5.684   1.000 13.149 0 14  TYR A CG  1 ? 
ATOM   93   C  CD1 . TYR A 1 14  ? -1.243  -29.761 6.547   1.000 13.143 0 14  TYR A CD1 1 ? 
ATOM   94   C  CD2 . TYR A 1 14  ? -1.010  -32.063 6.075   1.000 13.352 0 14  TYR A CD2 1 ? 
ATOM   95   C  CE1 . TYR A 1 14  ? -0.664  -29.963 7.785   1.000 15.185 0 14  TYR A CE1 1 ? 
ATOM   96   C  CE2 . TYR A 1 14  ? -0.414  -32.269 7.289   1.000 13.363 0 14  TYR A CE2 1 ? 
ATOM   97   C  CZ  . TYR A 1 14  ? -0.254  -31.221 8.167   1.000 14.525 0 14  TYR A CZ  1 ? 
ATOM   98   O  OH  . TYR A 1 14  ? 0.363   -31.342 9.369   1.000 14.278 0 14  TYR A OH  1 ? 
ATOM   99   N  N   . GLN A 1 15  ? 0.621   -28.384 3.886   1.000 11.465 0 15  GLN A N   1 ? 
ATOM   100  C  CA  . GLN A 1 15  ? 1.044   -27.025 4.161   1.000 12.100 0 15  GLN A CA  1 ? 
ATOM   101  C  C   . GLN A 1 15  ? 1.122   -26.256 2.845   1.000 11.525 0 15  GLN A C   1 ? 
ATOM   102  O  O   . GLN A 1 15  ? 1.739   -26.732 1.860   1.000 13.365 0 15  GLN A O   1 ? 
ATOM   103  C  CB  . GLN A 1 15  ? 2.461   -27.070 4.740   1.000 12.556 0 15  GLN A CB  1 ? 
ATOM   104  C  CG  . GLN A 1 15  ? 3.056   -25.683 4.970   1.000 12.126 0 15  GLN A CG  1 ? 
ATOM   105  C  CD  . GLN A 1 15  ? 2.571   -24.928 6.188   1.000 12.923 0 15  GLN A CD  1 ? 
ATOM   106  O  OE1 . GLN A 1 15  ? 2.540   -25.475 7.298   1.000 15.920 0 15  GLN A OE1 1 ? 
ATOM   107  N  NE2 . GLN A 1 15  ? 2.183   -23.675 6.054   1.000 14.776 0 15  GLN A NE2 1 ? 
ATOM   108  N  N   . VAL A 1 16  ? 0.548   -25.038 2.813   1.000 11.395 0 16  VAL A N   1 ? 
ATOM   109  C  CA  . VAL A 1 16  ? 0.767   -24.172 1.657   1.000 12.277 0 16  VAL A CA  1 ? 
ATOM   110  C  C   . VAL A 1 16  ? 1.373   -22.853 2.105   1.000 10.335 0 16  VAL A C   1 ? 
ATOM   111  O  O   . VAL A 1 16  ? 1.298   -22.430 3.260   1.000 10.455 0 16  VAL A O   1 ? 
ATOM   112  C  CB  . VAL A 1 16  ? -0.490  -23.950 0.816   1.000 18.200 0 16  VAL A CB  1 ? 
ATOM   113  C  CG1 . VAL A 1 16  ? -1.238  -25.269 0.605   1.000 19.998 0 16  VAL A CG1 1 ? 
ATOM   114  C  CG2 . VAL A 1 16  ? -1.392  -22.958 1.483   1.000 16.676 0 16  VAL A CG2 1 ? 
ATOM   115  N  N   . SER A 1 17  ? 2.004   -22.195 1.118   1.000 10.500 0 17  SER A N   1 ? 
ATOM   116  C  CA  . SER A 1 17  ? 2.484   -20.834 1.256   1.000 11.507 0 17  SER A CA  1 ? 
ATOM   117  C  C   . SER A 1 17  ? 1.558   -19.941 0.447   1.000 10.970 0 17  SER A C   1 ? 
ATOM   118  O  O   . SER A 1 17  ? 1.274   -20.297 -0.700  1.000 14.986 0 17  SER A O   1 ? 
ATOM   119  C  CB  . SER A 1 17  ? 3.904   -20.706 0.726   1.000 12.211 0 17  SER A CB  1 ? 
ATOM   120  O  OG  . SER A 1 17  ? 4.279   -19.328 0.582   1.000 12.662 0 17  SER A OG  1 ? 
ATOM   121  N  N   . LEU A 1 18  ? 1.112   -18.833 1.029   1.000 11.392 0 18  LEU A N   1 ? 
ATOM   122  C  CA  . LEU A 1 18  ? 0.402   -17.810 0.285   1.000 10.730 0 18  LEU A CA  1 ? 
ATOM   123  C  C   . LEU A 1 18  ? 1.406   -16.754 -0.147  1.000 12.260 0 18  LEU A C   1 ? 
ATOM   124  O  O   . LEU A 1 18  ? 2.133   -16.222 0.676   1.000 11.556 0 18  LEU A O   1 ? 
ATOM   125  C  CB  . LEU A 1 18  ? -0.722  -17.194 1.096   1.000 11.164 0 18  LEU A CB  1 ? 
ATOM   126  C  CG  . LEU A 1 18  ? -1.713  -18.199 1.702   1.000 12.857 0 18  LEU A CG  1 ? 
ATOM   127  C  CD1 . LEU A 1 18  ? -2.800  -17.386 2.417   1.000 13.418 0 18  LEU A CD1 1 ? 
ATOM   128  C  CD2 . LEU A 1 18  ? -2.271  -19.154 0.691   1.000 14.657 0 18  LEU A CD2 1 ? 
ATOM   129  N  N   . ASN A 1 19  ? 1.380   -16.424 -1.437  1.000 11.804 0 19  ASN A N   1 ? 
ATOM   130  C  CA  . ASN A 1 19  ? 2.388   -15.591 -2.052  1.000 11.449 0 19  ASN A CA  1 ? 
ATOM   131  C  C   . ASN A 1 19  ? 1.715   -14.408 -2.746  1.000 12.530 0 19  ASN A C   1 ? 
ATOM   132  O  O   . ASN A 1 19  ? 0.846   -14.627 -3.554  1.000 14.647 0 19  ASN A O   1 ? 
ATOM   133  C  CB  . ASN A 1 19  ? 3.234   -16.406 -3.017  1.000 11.725 0 19  ASN A CB  1 ? 
ATOM   134  C  CG  . ASN A 1 19  ? 4.408   -15.635 -3.555  1.000 13.267 0 19  ASN A CG  1 ? 
ATOM   135  O  OD1 . ASN A 1 19  ? 4.238   -14.744 -4.383  1.000 14.143 0 19  ASN A OD1 1 ? 
ATOM   136  N  ND2 . ASN A 1 19  ? 5.599   -16.005 -3.136  1.000 13.576 0 19  ASN A ND2 1 ? 
ATOM   137  N  N   . SER A 1 20  ? 2.150   -13.198 -2.421  1.000 12.884 0 20  SER A N   1 ? 
ATOM   138  C  CA  . SER A 1 20  ? 1.675   -12.016 -3.104  1.000 15.250 0 20  SER A CA  1 ? 
ATOM   139  C  C   . SER A 1 20  ? 2.854   -11.216 -3.639  1.000 16.107 0 20  SER A C   1 ? 
ATOM   140  O  O   . SER A 1 20  ? 2.904   -10.009 -3.474  1.000 19.937 0 20  SER A O   1 ? 
ATOM   141  C  CB  . SER A 1 20  ? 0.867   -11.193 -2.140  1.000 19.294 0 20  SER A CB  1 ? 
ATOM   142  O  OG  . SER A 1 20  ? 1.715   -10.671 -1.118  1.000 22.834 0 20  SER A OG  1 ? 
ATOM   143  N  N   . GLY A 1 21  ? 3.782   -11.915 -4.280  1.000 14.450 0 21  GLY A N   1 ? 
ATOM   144  C  CA  . GLY A 1 21  ? 5.082   -11.356 -4.613  1.000 14.053 0 21  GLY A CA  1 ? 
ATOM   145  C  C   . GLY A 1 21  ? 6.179   -11.798 -3.660  1.000 14.069 0 21  GLY A C   1 ? 
ATOM   146  O  O   . GLY A 1 21  ? 7.354   -11.592 -3.917  1.000 14.972 0 21  GLY A O   1 ? 
ATOM   147  N  N   . TYR A 1 22  ? 5.776   -12.387 -2.534  1.000 12.193 0 22  TYR A N   1 ? 
ATOM   148  C  CA  . TYR A 1 22  ? 6.583   -12.804 -1.407  1.000 12.254 0 22  TYR A CA  1 ? 
ATOM   149  C  C   . TYR A 1 22  ? 5.686   -13.706 -0.570  1.000 11.285 0 22  TYR A C   1 ? 
ATOM   150  O  O   . TYR A 1 22  ? 4.459   -13.573 -0.629  1.000 13.133 0 22  TYR A O   1 ? 
ATOM   151  C  CB  . TYR A 1 22  ? 7.133   -11.643 -0.579  1.000 12.479 0 22  TYR A CB  1 ? 
ATOM   152  C  CG  . TYR A 1 22  ? 6.094   -10.598 -0.223  1.000 15.143 0 22  TYR A CG  1 ? 
ATOM   153  C  CD1 . TYR A 1 22  ? 5.779   -9.554  -1.085  1.000 17.885 0 22  TYR A CD1 1 ? 
ATOM   154  C  CD2 . TYR A 1 22  ? 5.366   -10.735 0.950   1.000 17.984 0 22  TYR A CD2 1 ? 
ATOM   155  C  CE1 . TYR A 1 22  ? 4.780   -8.643  -0.794  1.000 20.943 0 22  TYR A CE1 1 ? 
ATOM   156  C  CE2 . TYR A 1 22  ? 4.390   -9.807  1.265   1.000 18.764 0 22  TYR A CE2 1 ? 
ATOM   157  C  CZ  . TYR A 1 22  ? 4.090   -8.777  0.390   1.000 20.555 0 22  TYR A CZ  1 ? 
ATOM   158  O  OH  . TYR A 1 22  ? 3.102   -7.874  0.710   1.000 24.670 0 22  TYR A OH  1 ? 
ATOM   159  N  N   . HIS A 1 23  ? 6.286   -14.605 0.215   1.000 11.367 0 23  HIS A N   1 ? 
ATOM   160  C  CA  . HIS A 1 23  ? 5.528   -15.353 1.204   1.000 10.831 0 23  HIS A CA  1 ? 
ATOM   161  C  C   . HIS A 1 23  ? 5.043   -14.429 2.322   1.000 11.769 0 23  HIS A C   1 ? 
ATOM   162  O  O   . HIS A 1 23  ? 5.812   -13.668 2.904   1.000 12.972 0 23  HIS A O   1 ? 
ATOM   163  C  CB  . HIS A 1 23  ? 6.395   -16.425 1.853   1.000 11.259 0 23  HIS A CB  1 ? 
ATOM   164  C  CG  . HIS A 1 23  ? 5.809   -17.077 3.047   1.000 11.604 0 23  HIS A CG  1 ? 
ATOM   165  N  ND1 . HIS A 1 23  ? 4.969   -18.150 2.984   1.000 12.427 0 23  HIS A ND1 1 ? 
ATOM   166  C  CD2 . HIS A 1 23  ? 5.892   -16.704 4.335   1.000 12.183 0 23  HIS A CD2 1 ? 
ATOM   167  C  CE1 . HIS A 1 23  ? 4.561   -18.420 4.235   1.000 12.430 0 23  HIS A CE1 1 ? 
ATOM   168  N  NE2 . HIS A 1 23  ? 5.132   -17.563 5.065   1.000 11.747 0 23  HIS A NE2 1 ? 
ATOM   169  N  N   . PHE A 1 24  ? 3.758   -14.569 2.677   1.000 11.069 0 24  PHE A N   1 ? 
ATOM   170  C  CA  . PHE A 1 24  ? 3.236   -13.710 3.718   1.000 10.884 0 24  PHE A CA  1 ? 
ATOM   171  C  C   . PHE A 1 24  ? 2.411   -14.493 4.743   1.000 11.081 0 24  PHE A C   1 ? 
ATOM   172  O  O   . PHE A 1 24  ? 2.117   -13.917 5.770   1.000 12.664 0 24  PHE A O   1 ? 
ATOM   173  C  CB  . PHE A 1 24  ? 2.508   -12.499 3.088   1.000 12.623 0 24  PHE A CB  1 ? 
ATOM   174  C  CG  . PHE A 1 24  ? 1.186   -12.841 2.428   1.000 13.066 0 24  PHE A CG  1 ? 
ATOM   175  C  CD1 . PHE A 1 24  ? 0.001   -12.841 3.173   1.000 15.118 0 24  PHE A CD1 1 ? 
ATOM   176  C  CD2 . PHE A 1 24  ? 1.084   -13.210 1.082   1.000 12.481 0 24  PHE A CD2 1 ? 
ATOM   177  C  CE1 . PHE A 1 24  ? -1.172  -13.204 2.579   1.000 15.222 0 24  PHE A CE1 1 ? 
ATOM   178  C  CE2 . PHE A 1 24  ? -0.103  -13.557 0.500   1.000 14.788 0 24  PHE A CE2 1 ? 
ATOM   179  C  CZ  . PHE A 1 24  ? -1.246  -13.545 1.250   1.000 15.819 0 24  PHE A CZ  1 ? 
ATOM   180  N  N   . CYS A 1 25  ? 1.926   -15.680 4.428   1.000 9.526  0 25  CYS A N   1 ? 
ATOM   181  C  CA  . CYS A 1 25  ? 1.083   -16.433 5.348   1.000 10.237 0 25  CYS A CA  1 ? 
ATOM   182  C  C   . CYS A 1 25  ? 1.109   -17.885 4.902   1.000 9.895  0 25  CYS A C   1 ? 
ATOM   183  O  O   . CYS A 1 25  ? 1.463   -18.231 3.780   1.000 11.835 0 25  CYS A O   1 ? 
ATOM   184  C  CB  . CYS A 1 25  ? -0.385  -15.955 5.351   1.000 9.681  0 25  CYS A CB  1 ? 
ATOM   185  S  SG  . CYS A 1 25  ? -0.734  -14.606 6.471   1.000 11.128 0 25  CYS A SG  1 ? 
ATOM   186  N  N   . GLY A 1 26  ? 0.731   -18.758 5.832   1.000 9.853  0 26  GLY A N   1 ? 
ATOM   187  C  CA  . GLY A 1 26  ? 0.530   -20.151 5.493   1.000 9.133  0 26  GLY A CA  1 ? 
ATOM   188  C  C   . GLY A 1 26  ? -0.935  -20.439 5.328   1.000 10.114 0 26  GLY A C   1 ? 
ATOM   189  O  O   . GLY A 1 26  ? -1.776  -19.548 5.366   1.000 9.559  0 26  GLY A O   1 ? 
ATOM   190  N  N   . GLY A 1 27  ? -1.187  -21.696 5.004   1.000 9.500  0 27  GLY A N   1 ? 
ATOM   191  C  CA  . GLY A 1 27  ? -2.536  -22.171 4.893   1.000 10.395 0 27  GLY A CA  1 ? 
ATOM   192  C  C   . GLY A 1 27  ? -2.513  -23.691 4.859   1.000 10.694 0 27  GLY A C   1 ? 
ATOM   193  O  O   . GLY A 1 27  ? -1.431  -24.273 4.868   1.000 9.086  0 27  GLY A O   1 ? 
ATOM   194  N  N   . SER A 1 28  ? -3.681  -24.314 4.747   1.000 10.445 0 28  SER A N   1 ? 
ATOM   195  C  CA  . SER A 1 28  ? -3.828  -25.770 4.708   1.000 12.786 0 28  SER A CA  1 ? 
ATOM   196  C  C   . SER A 1 28  ? -4.708  -26.197 3.543   1.000 11.901 0 28  SER A C   1 ? 
ATOM   197  O  O   . SER A 1 28  ? -5.765  -25.636 3.385   1.000 12.387 0 28  SER A O   1 ? 
ATOM   198  C  CB  . SER A 1 28  ? -4.445  -26.309 6.002   1.000 14.130 0 28  SER A CB  1 ? 
ATOM   199  O  OG  . SER A 1 28  ? -3.709  -25.934 7.162   1.000 17.128 0 28  SER A OG  1 ? 
ATOM   200  N  N   . LEU A 1 29  ? -4.279  -27.194 2.784   1.000 10.769 0 29  LEU A N   1 ? 
ATOM   201  C  CA  . LEU A 1 29  ? -5.047  -27.774 1.689   1.000 12.274 0 29  LEU A CA  1 ? 
ATOM   202  C  C   . LEU A 1 29  ? -6.068  -28.758 2.251   1.000 12.385 0 29  LEU A C   1 ? 
ATOM   203  O  O   . LEU A 1 29  ? -5.664  -29.726 2.880   1.000 13.881 0 29  LEU A O   1 ? 
ATOM   204  C  CB  . LEU A 1 29  ? -4.113  -28.464 0.706   1.000 15.335 0 29  LEU A CB  1 ? 
ATOM   205  C  CG  . LEU A 1 29  ? -4.772  -28.914 -0.591  1.000 19.034 0 29  LEU A CG  1 ? 
ATOM   206  C  CD1 . LEU A 1 29  ? -5.106  -27.724 -1.470  1.000 18.205 0 29  LEU A CD1 1 ? 
ATOM   207  C  CD2 . LEU A 1 29  ? -3.795  -29.853 -1.323  1.000 21.320 0 29  LEU A CD2 1 ? 
ATOM   208  N  N   . ILE A 1 30  ? -7.370  -28.492 2.068   1.000 12.770 0 30  ILE A N   1 ? 
ATOM   209  C  CA  . ILE A 1 30  ? -8.394  -29.369 2.615   1.000 13.448 0 30  ILE A CA  1 ? 
ATOM   210  C  C   . ILE A 1 30  ? -9.026  -30.266 1.559   1.000 15.493 0 30  ILE A C   1 ? 
ATOM   211  O  O   . ILE A 1 30  ? -9.661  -31.263 1.916   1.000 17.273 0 30  ILE A O   1 ? 
ATOM   212  C  CB  . ILE A 1 30  ? -9.429  -28.584 3.454   1.000 15.129 0 30  ILE A CB  1 ? 
ATOM   213  C  CG1 . ILE A 1 30  ? -10.110 -27.489 2.686   1.000 15.712 0 30  ILE A CG1 1 ? 
ATOM   214  C  CG2 . ILE A 1 30  ? -8.718  -28.099 4.719   1.000 15.915 0 30  ILE A CG2 1 ? 
ATOM   215  C  CD1 . ILE A 1 30  ? -11.429 -27.006 3.293   1.000 18.400 0 30  ILE A CD1 1 ? 
ATOM   216  N  N   . ASN A 1 31  ? -8.893  -29.911 0.303   1.000 15.642 0 31  ASN A N   1 ? 
ATOM   217  C  CA  . ASN A 1 31  ? -9.230  -30.811 -0.791  1.000 17.610 0 31  ASN A CA  1 ? 
ATOM   218  C  C   . ASN A 1 31  ? -8.484  -30.274 -2.010  1.000 18.653 0 31  ASN A C   1 ? 
ATOM   219  O  O   . ASN A 1 31  ? -7.636  -29.385 -1.898  1.000 19.439 0 31  ASN A O   1 ? 
ATOM   220  C  CB  . ASN A 1 31  ? -10.745 -30.951 -0.953  1.000 20.821 0 31  ASN A CB  1 ? 
ATOM   221  C  CG  . ASN A 1 31  ? -11.403 -29.629 -1.285  1.000 19.881 0 31  ASN A CG  1 ? 
ATOM   222  O  OD1 . ASN A 1 31  ? -10.913 -28.848 -2.107  1.000 19.332 0 31  ASN A OD1 1 ? 
ATOM   223  N  ND2 . ASN A 1 31  ? -12.495 -29.318 -0.617  1.000 25.072 0 31  ASN A ND2 1 ? 
ATOM   224  N  N   . SER A 1 32  ? -8.748  -30.787 -3.218  1.000 18.776 0 32  SER A N   1 ? 
ATOM   225  C  CA  . SER A 1 32  ? -7.927  -30.413 -4.354  1.000 18.637 0 32  SER A CA  1 ? 
ATOM   226  C  C   . SER A 1 32  ? -8.171  -28.992 -4.855  1.000 19.250 0 32  SER A C   1 ? 
ATOM   227  O  O   . SER A 1 32  ? -7.359  -28.504 -5.631  1.000 23.041 0 32  SER A O   1 ? 
ATOM   228  C  CB  . SER A 1 32  ? -8.110  -31.412 -5.514  1.000 21.348 0 32  SER A CB  1 ? 
ATOM   229  O  OG  . SER A 1 32  ? -9.437  -31.285 -5.953  1.000 21.907 0 32  SER A OG  1 ? 
ATOM   230  N  N   . GLN A 1 33  ? -9.222  -28.322 -4.381  1.000 16.362 0 33  GLN A N   1 ? 
ATOM   231  C  CA  . GLN A 1 33  ? -9.531  -26.992 -4.851  1.000 17.362 0 33  GLN A CA  1 ? 
ATOM   232  C  C   . GLN A 1 33  ? -9.604  -25.907 -3.773  1.000 13.720 0 33  GLN A C   1 ? 
ATOM   233  O  O   . GLN A 1 33  ? -9.837  -24.759 -4.140  1.000 14.678 0 33  GLN A O   1 ? 
ATOM   234  C  CB  . GLN A 1 33  ? -10.868 -27.024 -5.581  1.000 22.149 0 33  GLN A CB  1 ? 
ATOM   235  C  CG  . GLN A 1 33  ? -10.744 -27.659 -6.957  1.000 28.629 0 33  GLN A CG  1 ? 
ATOM   236  C  CD  . GLN A 1 33  ? -11.313 -26.781 -8.051  1.000 35.515 0 33  GLN A CD  1 ? 
ATOM   237  O  OE1 . GLN A 1 33  ? -10.618 -25.972 -8.687  1.000 40.270 0 33  GLN A OE1 1 ? 
ATOM   238  N  NE2 . GLN A 1 33  ? -12.628 -26.833 -8.155  1.000 34.987 0 33  GLN A NE2 1 ? 
ATOM   239  N  N   . TRP A 1 34  ? -9.444  -26.276 -2.497  1.000 12.385 0 34  TRP A N   1 ? 
ATOM   240  C  CA  . TRP A 1 34  ? -9.664  -25.323 -1.421  1.000 12.003 0 34  TRP A CA  1 ? 
ATOM   241  C  C   . TRP A 1 34  ? -8.579  -25.377 -0.352  1.000 11.549 0 34  TRP A C   1 ? 
ATOM   242  O  O   . TRP A 1 34  ? -8.096  -26.438 0.032   1.000 12.680 0 34  TRP A O   1 ? 
ATOM   243  C  CB  . TRP A 1 34  ? -10.992 -25.590 -0.712  1.000 12.554 0 34  TRP A CB  1 ? 
ATOM   244  C  CG  . TRP A 1 34  ? -12.187 -25.282 -1.564  1.000 13.048 0 34  TRP A CG  1 ? 
ATOM   245  C  CD1 . TRP A 1 34  ? -12.832 -26.132 -2.427  1.000 13.688 0 34  TRP A CD1 1 ? 
ATOM   246  C  CD2 . TRP A 1 34  ? -12.901 -24.040 -1.621  1.000 13.634 0 34  TRP A CD2 1 ? 
ATOM   247  N  NE1 . TRP A 1 34  ? -13.893 -25.483 -2.994  1.000 14.302 0 34  TRP A NE1 1 ? 
ATOM   248  C  CE2 . TRP A 1 34  ? -13.965 -24.206 -2.524  1.000 14.219 0 34  TRP A CE2 1 ? 
ATOM   249  C  CE3 . TRP A 1 34  ? -12.742 -22.804 -1.001  1.000 13.981 0 34  TRP A CE3 1 ? 
ATOM   250  C  CZ2 . TRP A 1 34  ? -14.872 -23.192 -2.797  1.000 14.399 0 34  TRP A CZ2 1 ? 
ATOM   251  C  CZ3 . TRP A 1 34  ? -13.624 -21.791 -1.285  1.000 14.597 0 34  TRP A CZ3 1 ? 
ATOM   252  C  CH2 . TRP A 1 34  ? -14.726 -22.015 -2.117  1.000 16.185 0 34  TRP A CH2 1 ? 
ATOM   253  N  N   . VAL A 1 35  ? -8.265  -24.173 0.138   1.000 12.064 0 35  VAL A N   1 ? 
ATOM   254  C  CA  . VAL A 1 35  ? -7.310  -23.937 1.195   1.000 11.044 0 35  VAL A CA  1 ? 
ATOM   255  C  C   . VAL A 1 35  ? -8.011  -23.169 2.304   1.000 10.080 0 35  VAL A C   1 ? 
ATOM   256  O  O   . VAL A 1 35  ? -8.848  -22.303 2.025   1.000 12.207 0 35  VAL A O   1 ? 
ATOM   257  C  CB  . VAL A 1 35  ? -6.201  -23.087 0.580   1.000 12.591 0 35  VAL A CB  1 ? 
ATOM   258  C  CG1 . VAL A 1 35  ? -5.344  -22.445 1.662   1.000 13.239 0 35  VAL A CG1 1 ? 
ATOM   259  C  CG2 . VAL A 1 35  ? -5.413  -23.911 -0.434  1.000 14.288 0 35  VAL A CG2 1 ? 
ATOM   260  N  N   . VAL A 1 36  ? -7.648  -23.538 3.526   1.000 9.868  0 36  VAL A N   1 ? 
ATOM   261  C  CA  . VAL A 1 36  ? -8.069  -22.810 4.701   1.000 10.566 0 36  VAL A CA  1 ? 
ATOM   262  C  C   . VAL A 1 36  ? -6.883  -21.986 5.183   1.000 11.111 0 36  VAL A C   1 ? 
ATOM   263  O  O   . VAL A 1 36  ? -5.772  -22.494 5.326   1.000 10.465 0 36  VAL A O   1 ? 
ATOM   264  C  CB  . VAL A 1 36  ? -8.557  -23.737 5.838   1.000 14.214 0 36  VAL A CB  1 ? 
ATOM   265  C  CG1 . VAL A 1 36  ? -8.888  -22.891 7.063   1.000 18.555 0 36  VAL A CG1 1 ? 
ATOM   266  C  CG2 . VAL A 1 36  ? -9.757  -24.573 5.452   1.000 17.278 0 36  VAL A CG2 1 ? 
ATOM   267  N  N   . SER A 1 37  ? -7.132  -20.729 5.561   1.000 10.015 0 37  SER A N   1 ? 
ATOM   268  C  CA  . SER A 1 37  ? -6.130  -19.896 6.199   1.000 10.322 0 37  SER A CA  1 ? 
ATOM   269  C  C   . SER A 1 37  ? -6.805  -18.984 7.204   1.000 10.806 0 37  SER A C   1 ? 
ATOM   270  O  O   . SER A 1 37  ? -7.965  -19.173 7.560   1.000 10.835 0 37  SER A O   1 ? 
ATOM   271  C  CB  . SER A 1 37  ? -5.393  -19.181 5.092   1.000 10.842 0 37  SER A CB  1 ? 
ATOM   272  O  OG  . SER A 1 37  ? -4.311  -18.403 5.568   1.000 9.859  0 37  SER A OG  1 ? 
ATOM   273  N  N   . ALA A 1 38  ? -6.094  -17.991 7.693   1.000 9.860  0 38  ALA A N   1 ? 
ATOM   274  C  CA  . ALA A 1 38  ? -6.628  -16.985 8.598   1.000 10.332 0 38  ALA A CA  1 ? 
ATOM   275  C  C   . ALA A 1 38  ? -7.195  -15.830 7.798   1.000 10.598 0 38  ALA A C   1 ? 
ATOM   276  O  O   . ALA A 1 38  ? -6.571  -15.346 6.849   1.000 9.975  0 38  ALA A O   1 ? 
ATOM   277  C  CB  . ALA A 1 38  ? -5.508  -16.444 9.418   1.000 10.487 0 38  ALA A CB  1 ? 
ATOM   278  N  N   . ALA A 1 39  ? -8.302  -15.266 8.293   1.000 8.986  0 39  ALA A N   1 ? 
ATOM   279  C  CA  . ALA A 1 39  ? -8.885  -14.087 7.690   1.000 9.417  0 39  ALA A CA  1 ? 
ATOM   280  C  C   . ALA A 1 39  ? -7.917  -12.912 7.745   1.000 9.907  0 39  ALA A C   1 ? 
ATOM   281  O  O   . ALA A 1 39  ? -7.974  -12.071 6.871   1.000 10.806 0 39  ALA A O   1 ? 
ATOM   282  C  CB  . ALA A 1 39  ? -10.171 -13.767 8.430   1.000 10.759 0 39  ALA A CB  1 ? 
ATOM   283  N  N   . HIS A 1 40  ? -7.118  -12.784 8.789   1.000 9.527  0 40  HIS A N   1 ? 
ATOM   284  C  CA  . HIS A 1 40  ? -6.165  -11.680 8.876   1.000 10.040 0 40  HIS A CA  1 ? 
ATOM   285  C  C   . HIS A 1 40  ? -5.073  -11.757 7.821   1.000 10.434 0 40  HIS A C   1 ? 
ATOM   286  O  O   . HIS A 1 40  ? -4.363  -10.763 7.633   1.000 12.941 0 40  HIS A O   1 ? 
ATOM   287  C  CB  . HIS A 1 40  ? -5.690  -11.538 10.301  1.000 10.807 0 40  HIS A CB  1 ? 
ATOM   288  C  CG  . HIS A 1 40  ? -4.502  -12.332 10.625  1.000 10.811 0 40  HIS A CG  1 ? 
ATOM   289  N  ND1 . HIS A 1 40  ? -4.602  -13.437 11.441  1.000 12.182 0 40  HIS A ND1 1 ? 
ATOM   290  C  CD2 . HIS A 1 40  ? -3.186  -12.109 10.415  1.000 14.254 0 40  HIS A CD2 1 ? 
ATOM   291  C  CE1 . HIS A 1 40  ? -3.378  -13.904 11.621  1.000 13.437 0 40  HIS A CE1 1 ? 
ATOM   292  N  NE2 . HIS A 1 40  ? -2.486  -13.102 11.058  1.000 12.972 0 40  HIS A NE2 1 ? 
ATOM   293  N  N   . CYS A 1 41  ? -5.034  -12.843 7.054   1.000 10.837 0 41  CYS A N   1 ? 
ATOM   294  C  CA  . CYS A 1 41  ? -4.107  -12.993 5.947   1.000 12.708 0 41  CYS A CA  1 ? 
ATOM   295  C  C   . CYS A 1 41  ? -4.742  -12.553 4.638   1.000 13.081 0 41  CYS A C   1 ? 
ATOM   296  O  O   . CYS A 1 41  ? -4.137  -12.706 3.591   1.000 16.609 0 41  CYS A O   1 ? 
ATOM   297  C  CB  . CYS A 1 41  ? -3.632  -14.413 5.759   1.000 12.909 0 41  CYS A CB  1 ? 
ATOM   298  S  SG  . CYS A 1 41  ? -2.630  -15.065 7.104   1.000 12.744 0 41  CYS A SG  1 ? 
ATOM   299  N  N   . TYR A 1 42  ? -5.999  -12.107 4.626   1.000 11.529 0 42  TYR A N   1 ? 
ATOM   300  C  CA  . TYR A 1 42  ? -6.579  -11.707 3.363   1.000 11.369 0 42  TYR A CA  1 ? 
ATOM   301  C  C   . TYR A 1 42  ? -5.780  -10.624 2.645   1.000 12.934 0 42  TYR A C   1 ? 
ATOM   302  O  O   . TYR A 1 42  ? -5.421  -9.606  3.224   1.000 13.001 0 42  TYR A O   1 ? 
ATOM   303  C  CB  . TYR A 1 42  ? -7.989  -11.185 3.670   1.000 13.858 0 42  TYR A CB  1 ? 
ATOM   304  C  CG  . TYR A 1 42  ? -8.616  -10.637 2.405   1.000 14.931 0 42  TYR A CG  1 ? 
ATOM   305  C  CD1 . TYR A 1 42  ? -9.095  -11.533 1.473   1.000 16.252 0 42  TYR A CD1 1 ? 
ATOM   306  C  CD2 . TYR A 1 42  ? -8.584  -9.303  2.068   1.000 18.216 0 42  TYR A CD2 1 ? 
ATOM   307  C  CE1 . TYR A 1 42  ? -9.553  -11.120 0.240   1.000 19.850 0 42  TYR A CE1 1 ? 
ATOM   308  C  CE2 . TYR A 1 42  ? -9.129  -8.871  0.861   1.000 18.891 0 42  TYR A CE2 1 ? 
ATOM   309  C  CZ  . TYR A 1 42  ? -9.537  -9.791  -0.077  1.000 20.721 0 42  TYR A CZ  1 ? 
ATOM   310  O  OH  . TYR A 1 42  ? -10.027 -9.397  -1.310  1.000 30.855 0 42  TYR A OH  1 ? 
ATOM   311  N  N   . LYS A 1 43  ? -5.627  -10.861 1.350   1.000 14.369 0 43  LYS A N   1 ? 
ATOM   312  C  CA  . LYS A 1 43  ? -5.267  -9.835  0.390   1.000 17.848 0 43  LYS A CA  1 ? 
ATOM   313  C  C   . LYS A 1 43  ? -5.775  -10.267 -0.976  1.000 17.453 0 43  LYS A C   1 ? 
ATOM   314  O  O   . LYS A 1 43  ? -6.128  -11.420 -1.214  1.000 17.185 0 43  LYS A O   1 ? 
ATOM   315  C  CB  . LYS A 1 43  ? -3.788  -9.469  0.502   1.000 25.267 0 43  LYS A CB  1 ? 
ATOM   316  C  CG  . LYS A 1 43  ? -2.801  -10.486 0.205   1.000 30.436 0 43  LYS A CG  1 ? 
ATOM   317  C  CD  . LYS A 1 43  ? -1.405  -9.879  0.345   1.000 29.296 0 43  LYS A CD  1 ? 
ATOM   318  C  CE  . LYS A 1 43  ? -0.996  -9.564  1.712   1.000 31.537 0 43  LYS A CE  1 ? 
ATOM   319  N  NZ  . LYS A 1 43  ? 0.415   -9.179  1.673   1.000 37.756 0 43  LYS A NZ  1 ? 
ATOM   320  N  N   . SER A 1 44  ? -5.900  -9.296  -1.889  1.000 19.794 0 44  SER A N   1 ? 
ATOM   321  C  CA  . SER A 1 44  ? -6.258  -9.656  -3.255  1.000 22.027 0 44  SER A CA  1 ? 
ATOM   322  C  C   . SER A 1 44  ? -4.984  -10.116 -3.967  1.000 24.120 0 44  SER A C   1 ? 
ATOM   323  O  O   . SER A 1 44  ? -3.882  -9.750  -3.580  1.000 30.412 0 44  SER A O   1 ? 
ATOM   324  C  CB  . SER A 1 44  ? -6.931  -8.482  -3.953  1.000 28.508 0 44  SER A CB  1 ? 
ATOM   325  O  OG  . SER A 1 44  ? -6.051  -7.380  -3.939  1.000 35.157 0 44  SER A OG  1 ? 
ATOM   326  N  N   . GLY A 1 45  ? -5.099  -11.029 -4.929  1.000 25.603 0 45  GLY A N   1 ? 
ATOM   327  C  CA  . GLY A 1 45  ? -3.955  -11.324 -5.771  1.000 26.868 0 45  GLY A CA  1 ? 
ATOM   328  C  C   . GLY A 1 45  ? -3.071  -12.398 -5.152  1.000 27.153 0 45  GLY A C   1 ? 
ATOM   329  O  O   . GLY A 1 45  ? -1.840  -12.306 -5.204  1.000 33.371 0 45  GLY A O   1 ? 
ATOM   330  N  N   . ILE A 1 46  ? -3.707  -13.386 -4.536  1.000 19.999 0 46  ILE A N   1 ? 
ATOM   331  C  CA  . ILE A 1 46  ? -2.980  -14.464 -3.869  1.000 18.843 0 46  ILE A CA  1 ? 
ATOM   332  C  C   . ILE A 1 46  ? -2.642  -15.540 -4.884  1.000 16.746 0 46  ILE A C   1 ? 
ATOM   333  O  O   . ILE A 1 46  ? -3.498  -16.020 -5.648  1.000 16.132 0 46  ILE A O   1 ? 
ATOM   334  C  CB  . ILE A 1 46  ? -3.815  -15.037 -2.699  1.000 17.848 0 46  ILE A CB  1 ? 
ATOM   335  C  CG1 . ILE A 1 46  ? -4.032  -13.939 -1.658  1.000 21.990 0 46  ILE A CG1 1 ? 
ATOM   336  C  CG2 . ILE A 1 46  ? -3.195  -16.305 -2.070  1.000 17.936 0 46  ILE A CG2 1 ? 
ATOM   337  C  CD1 . ILE A 1 46  ? -4.865  -14.358 -0.464  1.000 24.342 0 46  ILE A CD1 1 ? 
ATOM   338  N  N   . GLN A 1 47  ? -1.394  -16.023 -4.813  1.000 13.470 0 47  GLN A N   1 ? 
ATOM   339  C  CA  . GLN A 1 47  ? -0.998  -17.258 -5.446  1.000 13.474 0 47  GLN A CA  1 ? 
ATOM   340  C  C   . GLN A 1 47  ? -0.721  -18.303 -4.367  1.000 13.808 0 47  GLN A C   1 ? 
ATOM   341  O  O   . GLN A 1 47  ? -0.028  -18.011 -3.397  1.000 16.986 0 47  GLN A O   1 ? 
ATOM   342  C  CB  . GLN A 1 47  ? 0.297   -17.083 -6.251  1.000 15.270 0 47  GLN A CB  1 ? 
ATOM   343  C  CG  . GLN A 1 47  ? 0.619   -18.300 -7.110  1.000 17.245 0 47  GLN A CG  1 ? 
ATOM   344  C  CD  . GLN A 1 47  ? 1.928   -18.120 -7.843  1.000 20.888 0 47  GLN A CD  1 ? 
ATOM   345  O  OE1 . GLN A 1 47  ? 2.981   -17.996 -7.232  1.000 21.101 0 47  GLN A OE1 1 ? 
ATOM   346  N  NE2 . GLN A 1 47  ? 1.823   -18.027 -9.160  1.000 23.922 0 47  GLN A NE2 1 ? 
ATOM   347  N  N   . VAL A 1 48  ? -1.299  -19.484 -4.515  1.000 13.790 0 48  VAL A N   1 ? 
ATOM   348  C  CA  . VAL A 1 48  ? -1.104  -20.535 -3.549  1.000 13.093 0 48  VAL A CA  1 ? 
ATOM   349  C  C   . VAL A 1 48  ? 0.041   -21.404 -4.040  1.000 14.693 0 48  VAL A C   1 ? 
ATOM   350  O  O   . VAL A 1 48  ? 0.047   -21.812 -5.193  1.000 14.076 0 48  VAL A O   1 ? 
ATOM   351  C  CB  . VAL A 1 48  ? -2.402  -21.341 -3.394  1.000 15.691 0 48  VAL A CB  1 ? 
ATOM   352  C  CG1 . VAL A 1 48  ? -2.199  -22.555 -2.526  1.000 17.287 0 48  VAL A CG1 1 ? 
ATOM   353  C  CG2 . VAL A 1 48  ? -3.514  -20.424 -2.917  1.000 14.864 0 48  VAL A CG2 1 ? 
ATOM   354  N  N   . ARG A 1 49  ? 0.998   -21.691 -3.146  1.000 13.053 0 49  ARG A N   1 ? 
ATOM   355  C  CA  . ARG A 1 49  ? 2.125   -22.533 -3.505  1.000 12.586 0 49  ARG A CA  1 ? 
ATOM   356  C  C   . ARG A 1 49  ? 2.102   -23.820 -2.683  1.000 13.351 0 49  ARG A C   1 ? 
ATOM   357  O  O   . ARG A 1 49  ? 2.156   -23.798 -1.445  1.000 13.383 0 49  ARG A O   1 ? 
ATOM   358  C  CB  . ARG A 1 49  ? 3.419   -21.748 -3.288  1.000 12.589 0 49  ARG A CB  1 ? 
ATOM   359  C  CG  . ARG A 1 49  ? 3.377   -20.504 -4.160  1.000 13.220 0 49  ARG A CG  1 ? 
ATOM   360  C  CD  . ARG A 1 49  ? 4.766   -19.892 -4.352  1.000 14.613 0 49  ARG A CD  1 ? 
ATOM   361  N  NE  . ARG A 1 49  ? 4.787   -18.908 -5.424  1.000 13.625 0 49  ARG A NE  1 ? 
ATOM   362  C  CZ  . ARG A 1 49  ? 5.927   -18.529 -6.003  1.000 14.801 0 49  ARG A CZ  1 ? 
ATOM   363  N  NH1 . ARG A 1 49  ? 7.058   -18.855 -5.390  1.000 15.614 0 49  ARG A NH1 1 ? 
ATOM   364  N  NH2 . ARG A 1 49  ? 5.898   -17.917 -7.177  1.000 16.991 0 49  ARG A NH2 1 ? 
ATOM   365  N  N   . LEU A 1 50  ? 1.969   -24.928 -3.412  1.000 13.674 0 50  LEU A N   1 ? 
ATOM   366  C  CA  . LEU A 1 50  ? 1.884   -26.255 -2.830  1.000 15.018 0 50  LEU A CA  1 ? 
ATOM   367  C  C   . LEU A 1 50  ? 3.172   -27.033 -3.076  1.000 14.584 0 50  LEU A C   1 ? 
ATOM   368  O  O   . LEU A 1 50  ? 3.911   -26.745 -4.003  1.000 15.981 0 50  LEU A O   1 ? 
ATOM   369  C  CB  . LEU A 1 50  ? 0.696   -26.970 -3.461  1.000 16.421 0 50  LEU A CB  1 ? 
ATOM   370  C  CG  . LEU A 1 50  ? -0.638  -26.227 -3.366  1.000 19.610 0 50  LEU A CG  1 ? 
ATOM   371  C  CD1 . LEU A 1 50  ? -0.873  -25.492 -4.670  1.000 24.722 0 50  LEU A CD1 1 ? 
ATOM   372  C  CD2 . LEU A 1 50  ? -1.735  -27.226 -3.126  1.000 28.090 0 50  LEU A CD2 1 ? 
ATOM   373  N  N   . GLY A 1 51  ? 3.420   -28.012 -2.215  1.000 14.197 0 51  GLY A N   1 ? 
ATOM   374  C  CA  . GLY A 1 51  ? 4.551   -28.912 -2.375  1.000 14.336 0 51  GLY A CA  1 ? 
ATOM   375  C  C   . GLY A 1 51  ? 5.879   -28.223 -2.078  1.000 15.303 0 51  GLY A C   1 ? 
ATOM   376  O  O   . GLY A 1 51  ? 6.917   -28.646 -2.576  1.000 20.329 0 51  GLY A O   1 ? 
ATOM   377  N  N   . GLU A 1 52  ? 5.838   -27.167 -1.282  1.000 14.523 0 52  GLU A N   1 ? 
ATOM   378  C  CA  . GLU A 1 52  ? 7.028   -26.385 -1.003  1.000 14.118 0 52  GLU A CA  1 ? 
ATOM   379  C  C   . GLU A 1 52  ? 7.809   -26.964 0.164   1.000 15.461 0 52  GLU A C   1 ? 
ATOM   380  O  O   . GLU A 1 52  ? 7.245   -27.419 1.171   1.000 14.888 0 52  GLU A O   1 ? 
ATOM   381  C  CB  . GLU A 1 52  ? 6.650   -24.945 -0.632  1.000 13.846 0 52  GLU A CB  1 ? 
ATOM   382  C  CG  . GLU A 1 52  ? 6.253   -24.107 -1.836  1.000 12.929 0 52  GLU A CG  1 ? 
ATOM   383  C  CD  . GLU A 1 52  ? 7.492   -23.634 -2.617  1.000 14.468 0 52  GLU A CD  1 ? 
ATOM   384  O  OE1 . GLU A 1 52  ? 8.583   -24.246 -2.507  1.000 13.308 0 52  GLU A OE1 1 ? 
ATOM   385  O  OE2 . GLU A 1 52  ? 7.379   -22.644 -3.351  1.000 14.993 0 52  GLU A OE2 1 ? 
ATOM   386  N  N   . ASP A 1 53  ? 9.139   -26.903 0.048   1.000 14.530 0 53  ASP A N   1 ? 
ATOM   387  C  CA  . ASP A 1 53  ? 9.970   -27.005 1.220   1.000 15.406 0 53  ASP A CA  1 ? 
ATOM   388  C  C   . ASP A 1 53  ? 10.769  -25.729 1.369   1.000 14.352 0 53  ASP A C   1 ? 
ATOM   389  O  O   . ASP A 1 53  ? 10.538  -24.953 2.261   1.000 16.296 0 53  ASP A O   1 ? 
ATOM   390  C  CB  . ASP A 1 53  ? 10.874  -28.212 1.233   1.000 16.718 0 53  ASP A CB  1 ? 
ATOM   391  C  CG  . ASP A 1 53  ? 11.540  -28.418 2.585   1.000 22.467 0 53  ASP A CG  1 ? 
ATOM   392  O  OD1 . ASP A 1 53  ? 10.875  -28.237 3.636   1.000 22.117 0 53  ASP A OD1 1 ? 
ATOM   393  O  OD2 . ASP A 1 53  ? 12.722  -28.782 2.568   1.000 24.893 0 53  ASP A OD2 1 ? 
ATOM   394  N  N   . ASN A 1 54  ? 11.720  -25.527 0.483   1.000 15.925 0 54  ASN A N   1 ? 
ATOM   395  C  CA  . ASN A 1 54  ? 12.462  -24.291 0.439   1.000 15.885 0 54  ASN A CA  1 ? 
ATOM   396  C  C   . ASN A 1 54  ? 11.684  -23.287 -0.400  1.000 14.570 0 54  ASN A C   1 ? 
ATOM   397  O  O   . ASN A 1 54  ? 11.511  -23.525 -1.584  1.000 15.702 0 54  ASN A O   1 ? 
ATOM   398  C  CB  . ASN A 1 54  ? 13.824  -24.509 -0.198  1.000 15.137 0 54  ASN A CB  1 ? 
ATOM   399  C  CG  . ASN A 1 54  ? 14.686  -23.292 -0.016  1.000 17.585 0 54  ASN A CG  1 ? 
ATOM   400  O  OD1 . ASN A 1 54  ? 14.247  -22.175 -0.266  1.000 15.831 0 54  ASN A OD1 1 ? 
ATOM   401  N  ND2 . ASN A 1 54  ? 15.924  -23.470 0.405   1.000 19.668 0 54  ASN A ND2 1 ? 
ATOM   402  N  N   . ILE A 1 55  ? 11.147  -22.231 0.220   1.000 15.358 0 55  ILE A N   1 ? 
ATOM   403  C  CA  . ILE A 1 55  ? 10.271  -21.304 -0.498  1.000 15.332 0 55  ILE A CA  1 ? 
ATOM   404  C  C   . ILE A 1 55  ? 11.054  -20.431 -1.463  1.000 14.822 0 55  ILE A C   1 ? 
ATOM   405  O  O   . ILE A 1 55  ? 10.423  -19.805 -2.300  1.000 15.386 0 55  ILE A O   1 ? 
ATOM   406  C  CB  . ILE A 1 55  ? 9.369   -20.431 0.394   1.000 16.380 0 55  ILE A CB  1 ? 
ATOM   407  C  CG1 . ILE A 1 55  ? 10.179  -19.768 1.498   1.000 18.365 0 55  ILE A CG1 1 ? 
ATOM   408  C  CG2 . ILE A 1 55  ? 8.177   -21.265 0.912   1.000 18.035 0 55  ILE A CG2 1 ? 
ATOM   409  C  CD1 . ILE A 1 55  ? 9.393   -18.711 2.263   1.000 20.953 0 55  ILE A CD1 1 ? 
ATOM   410  N  N   . ASN A 1 56  ? 12.401  -20.452 -1.424  1.000 13.991 0 56  ASN A N   1 ? 
ATOM   411  C  CA  . ASN A 1 56  ? 13.190  -19.545 -2.255  1.000 14.495 0 56  ASN A CA  1 ? 
ATOM   412  C  C   . ASN A 1 56  ? 13.863  -20.267 -3.425  1.000 15.847 0 56  ASN A C   1 ? 
ATOM   413  O  O   . ASN A 1 56  ? 14.465  -19.618 -4.307  1.000 16.543 0 56  ASN A O   1 ? 
ATOM   414  C  CB  . ASN A 1 56  ? 14.231  -18.790 -1.446  1.000 16.659 0 56  ASN A CB  1 ? 
ATOM   415  C  CG  . ASN A 1 56  ? 13.639  -17.555 -0.822  1.000 22.214 0 56  ASN A CG  1 ? 
ATOM   416  O  OD1 . ASN A 1 56  ? 12.949  -16.779 -1.520  1.000 25.420 0 56  ASN A OD1 1 ? 
ATOM   417  N  ND2 . ASN A 1 56  ? 14.010  -17.315 0.421   1.000 25.908 0 56  ASN A ND2 1 ? 
ATOM   418  N  N   . VAL A 1 57  ? 13.685  -21.583 -3.501  1.000 14.592 0 57  VAL A N   1 ? 
ATOM   419  C  CA  . VAL A 1 57  ? 14.306  -22.383 -4.560  1.000 15.608 0 57  VAL A CA  1 ? 
ATOM   420  C  C   . VAL A 1 57  ? 13.270  -23.301 -5.162  1.000 15.148 0 57  VAL A C   1 ? 
ATOM   421  O  O   . VAL A 1 57  ? 12.573  -23.952 -4.398  1.000 14.543 0 57  VAL A O   1 ? 
ATOM   422  C  CB  . VAL A 1 57  ? 15.475  -23.206 -3.987  1.000 17.351 0 57  VAL A CB  1 ? 
ATOM   423  C  CG1 . VAL A 1 57  ? 16.131  -24.069 -5.057  1.000 20.990 0 57  VAL A CG1 1 ? 
ATOM   424  C  CG2 . VAL A 1 57  ? 16.469  -22.287 -3.287  1.000 20.966 0 57  VAL A CG2 1 ? 
ATOM   425  N  N   . VAL A 1 58  ? 13.192  -23.422 -6.504  1.000 18.044 0 58  VAL A N   1 ? 
ATOM   426  C  CA  . VAL A 1 58  ? 12.302  -24.375 -7.149  1.000 19.200 0 58  VAL A CA  1 ? 
ATOM   427  C  C   . VAL A 1 58  ? 12.968  -25.743 -7.097  1.000 19.564 0 58  VAL A C   1 ? 
ATOM   428  O  O   . VAL A 1 58  ? 14.022  -25.922 -7.687  1.000 22.414 0 58  VAL A O   1 ? 
ATOM   429  C  CB  . VAL A 1 58  ? 11.952  -23.937 -8.589  1.000 20.683 0 58  VAL A CB  1 ? 
ATOM   430  C  CG1 . VAL A 1 58  ? 11.180  -25.010 -9.349  1.000 22.849 0 58  VAL A CG1 1 ? 
ATOM   431  C  CG2 . VAL A 1 58  ? 11.152  -22.663 -8.574  1.000 22.240 0 58  VAL A CG2 1 ? 
ATOM   432  N  N   . GLU A 1 59  ? 12.391  -26.700 -6.361  1.000 19.417 0 59  GLU A N   1 ? 
ATOM   433  C  CA  . GLU A 1 59  ? 13.055  -27.982 -6.176  1.000 25.312 0 59  GLU A CA  1 ? 
ATOM   434  C  C   . GLU A 1 59  ? 12.416  -29.067 -7.054  1.000 28.701 0 59  GLU A C   1 ? 
ATOM   435  O  O   . GLU A 1 59  ? 13.029  -30.110 -7.296  1.000 27.838 0 59  GLU A O   1 ? 
ATOM   436  C  CB  . GLU A 1 59  ? 13.286  -28.222 -4.682  1.000 30.059 0 59  GLU A CB  1 ? 
ATOM   437  C  CG  . GLU A 1 59  ? 12.044  -28.147 -3.808  1.000 34.879 0 59  GLU A CG  1 ? 
ATOM   438  C  CD  . GLU A 1 59  ? 12.044  -27.291 -2.538  1.000 31.936 0 59  GLU A CD  1 ? 
ATOM   439  O  OE1 . GLU A 1 59  ? 11.046  -26.516 -2.433  1.000 21.883 0 59  GLU A OE1 1 ? 
ATOM   440  O  OE2 . GLU A 1 59  ? 12.920  -27.432 -1.647  1.000 25.439 0 59  GLU A OE2 1 ? 
ATOM   441  N  N   . GLY A 1 60  ? 11.200  -28.825 -7.559  1.000 29.422 0 60  GLY A N   1 ? 
ATOM   442  C  CA  . GLY A 1 60  ? 10.651  -29.607 -8.653  1.000 28.843 0 60  GLY A CA  1 ? 
ATOM   443  C  C   . GLY A 1 60  ? 9.300   -30.227 -8.313  1.000 30.250 0 60  GLY A C   1 ? 
ATOM   444  O  O   . GLY A 1 60  ? 8.710   -30.886 -9.165  1.000 35.252 0 60  GLY A O   1 ? 
ATOM   445  N  N   . ASN A 1 61  ? 8.875   -30.114 -7.053  1.000 25.657 0 61  ASN A N   1 ? 
ATOM   446  C  CA  . ASN A 1 61  ? 7.655   -30.756 -6.607  1.000 26.810 0 61  ASN A CA  1 ? 
ATOM   447  C  C   . ASN A 1 61  ? 6.537   -29.738 -6.438  1.000 24.571 0 61  ASN A C   1 ? 
ATOM   448  O  O   . ASN A 1 61  ? 5.432   -30.089 -6.066  1.000 24.073 0 61  ASN A O   1 ? 
ATOM   449  C  CB  . ASN A 1 61  ? 7.869   -31.503 -5.298  1.000 31.405 0 61  ASN A CB  1 ? 
ATOM   450  C  CG  . ASN A 1 61  ? 8.753   -32.708 -5.509  1.000 36.592 0 61  ASN A CG  1 ? 
ATOM   451  O  OD1 . ASN A 1 61  ? 8.405   -33.582 -6.306  1.000 52.382 0 61  ASN A OD1 1 ? 
ATOM   452  N  ND2 . ASN A 1 61  ? 9.880   -32.778 -4.821  1.000 40.395 0 61  ASN A ND2 1 ? 
ATOM   453  N  N   . GLU A 1 62  ? 6.802   -28.473 -6.738  1.000 19.352 0 62  GLU A N   1 ? 
ATOM   454  C  CA  . GLU A 1 62  ? 5.843   -27.441 -6.412  1.000 18.497 0 62  GLU A CA  1 ? 
ATOM   455  C  C   . GLU A 1 62  ? 4.706   -27.362 -7.418  1.000 18.838 0 62  GLU A C   1 ? 
ATOM   456  O  O   . GLU A 1 62  ? 4.846   -27.708 -8.581  1.000 18.465 0 62  GLU A O   1 ? 
ATOM   457  C  CB  . GLU A 1 62  ? 6.501   -26.072 -6.453  1.000 17.017 0 62  GLU A CB  1 ? 
ATOM   458  C  CG  . GLU A 1 62  ? 7.635   -25.923 -5.444  1.000 16.466 0 62  GLU A CG  1 ? 
ATOM   459  C  CD  . GLU A 1 62  ? 9.029   -26.271 -5.928  1.000 17.250 0 62  GLU A CD  1 ? 
ATOM   460  O  OE1 . GLU A 1 62  ? 9.171   -27.006 -6.918  1.000 17.400 0 62  GLU A OE1 1 ? 
ATOM   461  O  OE2 . GLU A 1 62  ? 9.957   -25.829 -5.211  1.000 15.613 0 62  GLU A OE2 1 ? 
ATOM   462  N  N   . GLN A 1 63  ? 3.563   -26.862 -6.945  1.000 16.460 0 63  GLN A N   1 ? 
ATOM   463  C  CA  . GLN A 1 63  ? 2.484   -26.459 -7.834  1.000 17.155 0 63  GLN A CA  1 ? 
ATOM   464  C  C   . GLN A 1 63  ? 2.094   -25.056 -7.427  1.000 18.187 0 63  GLN A C   1 ? 
ATOM   465  O  O   . GLN A 1 63  ? 1.880   -24.821 -6.240  1.000 18.334 0 63  GLN A O   1 ? 
ATOM   466  C  CB  . GLN A 1 63  ? 1.293   -27.405 -7.688  1.000 18.719 0 63  GLN A CB  1 ? 
ATOM   467  C  CG  . GLN A 1 63  ? 1.605   -28.853 -8.059  1.000 20.174 0 63  GLN A CG  1 ? 
ATOM   468  C  CD  . GLN A 1 63  ? 0.448   -29.780 -7.781  1.000 21.908 0 63  GLN A CD  1 ? 
ATOM   469  O  OE1 . GLN A 1 63  ? -0.700  -29.462 -8.098  1.000 23.196 0 63  GLN A OE1 1 ? 
ATOM   470  N  NE2 . GLN A 1 63  ? 0.745   -30.922 -7.186  1.000 23.205 0 63  GLN A NE2 1 ? 
ATOM   471  N  N   . PHE A 1 64  ? 2.115   -24.110 -8.374  1.000 16.474 0 64  PHE A N   1 ? 
ATOM   472  C  CA  . PHE A 1 64  ? 1.774   -22.726 -8.103  1.000 15.966 0 64  PHE A CA  1 ? 
ATOM   473  C  C   . PHE A 1 64  ? 0.449   -22.425 -8.796  1.000 18.942 0 64  PHE A C   1 ? 
ATOM   474  O  O   . PHE A 1 64  ? 0.336   -22.523 -10.030 1.000 18.170 0 64  PHE A O   1 ? 
ATOM   475  C  CB  . PHE A 1 64  ? 2.793   -21.722 -8.632  1.000 17.898 0 64  PHE A CB  1 ? 
ATOM   476  C  CG  . PHE A 1 64  ? 4.213   -21.824 -8.099  1.000 17.639 0 64  PHE A CG  1 ? 
ATOM   477  C  CD1 . PHE A 1 64  ? 4.532   -22.554 -6.968  1.000 17.812 0 64  PHE A CD1 1 ? 
ATOM   478  C  CD2 . PHE A 1 64  ? 5.234   -21.144 -8.738  1.000 21.964 0 64  PHE A CD2 1 ? 
ATOM   479  C  CE1 . PHE A 1 64  ? 5.819   -22.569 -6.466  1.000 18.770 0 64  PHE A CE1 1 ? 
ATOM   480  C  CE2 . PHE A 1 64  ? 6.526   -21.191 -8.252  1.000 21.470 0 64  PHE A CE2 1 ? 
ATOM   481  C  CZ  . PHE A 1 64  ? 6.819   -21.927 -7.138  1.000 20.971 0 64  PHE A CZ  1 ? 
ATOM   482  N  N   . ILE A 1 65  ? -0.574  -22.114 -8.013  1.000 14.373 0 65  ILE A N   1 ? 
ATOM   483  C  CA  . ILE A 1 65  ? -1.925  -21.964 -8.537  1.000 15.975 0 65  ILE A CA  1 ? 
ATOM   484  C  C   . ILE A 1 65  ? -2.518  -20.679 -7.980  1.000 16.043 0 65  ILE A C   1 ? 
ATOM   485  O  O   . ILE A 1 65  ? -2.536  -20.482 -6.774  1.000 16.012 0 65  ILE A O   1 ? 
ATOM   486  C  CB  . ILE A 1 65  ? -2.774  -23.186 -8.152  1.000 16.785 0 65  ILE A CB  1 ? 
ATOM   487  C  CG1 . ILE A 1 65  ? -2.143  -24.525 -8.593  1.000 19.718 0 65  ILE A CG1 1 ? 
ATOM   488  C  CG2 . ILE A 1 65  ? -4.202  -23.023 -8.693  1.000 18.781 0 65  ILE A CG2 1 ? 
ATOM   489  C  CD1 . ILE A 1 65  ? -2.813  -25.756 -8.006  1.000 22.187 0 65  ILE A CD1 1 ? 
ATOM   490  N  N   . SER A 1 66  ? -3.090  -19.835 -8.852  1.000 15.610 0 66  SER A N   1 ? 
ATOM   491  C  CA  . SER A 1 66  ? -3.681  -18.588 -8.453  1.000 16.588 0 66  SER A CA  1 ? 
ATOM   492  C  C   . SER A 1 66  ? -5.002  -18.882 -7.760  1.000 16.968 0 66  SER A C   1 ? 
ATOM   493  O  O   . SER A 1 66  ? -5.669  -19.872 -8.082  1.000 16.737 0 66  SER A O   1 ? 
ATOM   494  C  CB  . SER A 1 66  ? -3.950  -17.701 -9.653  1.000 22.220 0 66  SER A CB  1 ? 
ATOM   495  O  OG  . SER A 1 66  ? -2.715  -17.375 -10.275 1.000 28.062 0 66  SER A OG  1 ? 
ATOM   496  N  N   . ALA A 1 67  ? -5.351  -18.016 -6.821  1.000 17.381 0 67  ALA A N   1 ? 
ATOM   497  C  CA  . ALA A 1 67  ? -6.681  -18.055 -6.234  1.000 17.998 0 67  ALA A CA  1 ? 
ATOM   498  C  C   . ALA A 1 67  ? -7.724  -17.455 -7.172  1.000 16.741 0 67  ALA A C   1 ? 
ATOM   499  O  O   . ALA A 1 67  ? -7.547  -16.387 -7.755  1.000 19.551 0 67  ALA A O   1 ? 
ATOM   500  C  CB  . ALA A 1 67  ? -6.689  -17.303 -4.964  1.000 17.945 0 67  ALA A CB  1 ? 
ATOM   501  N  N   . SER A 1 68  ? -8.903  -18.073 -7.198  1.000 17.255 0 68  SER A N   1 ? 
ATOM   502  C  CA  . SER A 1 68  ? -9.994  -17.521 -7.970  1.000 18.496 0 68  SER A CA  1 ? 
ATOM   503  C  C   . SER A 1 68  ? -10.929 -16.701 -7.094  1.000 18.671 0 68  SER A C   1 ? 
ATOM   504  O  O   . SER A 1 68  ? -11.573 -15.764 -7.571  1.000 20.238 0 68  SER A O   1 ? 
ATOM   505  C  CB  . SER A 1 68  ? -10.739 -18.590 -8.706  1.000 20.614 0 68  SER A CB  1 ? 
ATOM   506  O  OG  . SER A 1 68  ? -11.328 -19.509 -7.811  1.000 23.146 0 68  SER A OG  1 ? 
ATOM   507  N  N   . LYS A 1 69  ? -11.065 -17.116 -5.833  1.000 17.903 0 69  LYS A N   1 ? 
ATOM   508  C  CA  . LYS A 1 69  ? -11.920 -16.395 -4.917  1.000 18.647 0 69  LYS A CA  1 ? 
ATOM   509  C  C   . LYS A 1 69  ? -11.447 -16.641 -3.495  1.000 15.982 0 69  LYS A C   1 ? 
ATOM   510  O  O   . LYS A 1 69  ? -10.817 -17.659 -3.199  1.000 16.283 0 69  LYS A O   1 ? 
ATOM   511  C  CB  . LYS A 1 69  ? -13.395 -16.780 -5.085  1.000 23.225 0 69  LYS A CB  1 ? 
ATOM   512  C  CG  . LYS A 1 69  ? -13.743 -18.218 -4.968  1.000 25.588 0 69  LYS A CG  1 ? 
ATOM   513  C  CD  . LYS A 1 69  ? -15.197 -18.611 -5.289  1.000 28.730 0 69  LYS A CD  1 ? 
ATOM   514  C  CE  . LYS A 1 69  ? -15.568 -18.838 -6.737  1.000 31.065 0 69  LYS A CE  1 ? 
ATOM   515  N  NZ  . LYS A 1 69  ? -16.864 -19.481 -7.021  1.000 30.702 0 69  LYS A NZ  1 ? 
ATOM   516  N  N   . SER A 1 70  ? -11.736 -15.668 -2.637  1.000 16.147 0 70  SER A N   1 ? 
ATOM   517  C  CA  . SER A 1 70  ? -11.399 -15.716 -1.225  1.000 16.310 0 70  SER A CA  1 ? 
ATOM   518  C  C   . SER A 1 70  ? -12.674 -15.407 -0.467  1.000 14.918 0 70  SER A C   1 ? 
ATOM   519  O  O   . SER A 1 70  ? -13.389 -14.490 -0.866  1.000 16.426 0 70  SER A O   1 ? 
ATOM   520  C  CB  . SER A 1 70  ? -10.327 -14.764 -0.827  1.000 20.620 0 70  SER A CB  1 ? 
ATOM   521  O  OG  . SER A 1 70  ? -9.115  -15.151 -1.445  1.000 27.813 0 70  SER A OG  1 ? 
ATOM   522  N  N   . ILE A 1 71  ? -12.916 -16.149 0.606   1.000 13.414 0 71  ILE A N   1 ? 
ATOM   523  C  CA  . ILE A 1 71  ? -14.143 -15.999 1.375   1.000 12.433 0 71  ILE A CA  1 ? 
ATOM   524  C  C   . ILE A 1 71  ? -13.778 -15.887 2.833   1.000 12.484 0 71  ILE A C   1 ? 
ATOM   525  O  O   . ILE A 1 71  ? -13.340 -16.847 3.444   1.000 12.282 0 71  ILE A O   1 ? 
ATOM   526  C  CB  . ILE A 1 71  ? -15.135 -17.144 1.145   1.000 14.974 0 71  ILE A CB  1 ? 
ATOM   527  C  CG1 . ILE A 1 71  ? -15.448 -17.241 -0.329  1.000 18.133 0 71  ILE A CG1 1 ? 
ATOM   528  C  CG2 . ILE A 1 71  ? -16.371 -16.893 2.008   1.000 15.717 0 71  ILE A CG2 1 ? 
ATOM   529  C  CD1 . ILE A 1 71  ? -16.266 -18.432 -0.700  1.000 21.179 0 71  ILE A CD1 1 ? 
ATOM   530  N  N   . VAL A 1 72  ? -13.899 -14.686 3.335   1.000 12.427 0 72  VAL A N   1 ? 
ATOM   531  C  CA  . VAL A 1 72  ? -13.593 -14.402 4.735   1.000 12.398 0 72  VAL A CA  1 ? 
ATOM   532  C  C   . VAL A 1 72  ? -14.822 -14.784 5.528   1.000 13.010 0 72  VAL A C   1 ? 
ATOM   533  O  O   . VAL A 1 72  ? -15.926 -14.600 5.039   1.000 14.076 0 72  VAL A O   1 ? 
ATOM   534  C  CB  . VAL A 1 72  ? -13.211 -12.926 4.914   1.000 13.640 0 72  VAL A CB  1 ? 
ATOM   535  C  CG1 . VAL A 1 72  ? -13.156 -12.495 6.357   1.000 14.681 0 72  VAL A CG1 1 ? 
ATOM   536  C  CG2 . VAL A 1 72  ? -11.917 -12.559 4.205   1.000 15.537 0 72  VAL A CG2 1 ? 
ATOM   537  N  N   . HIS A 1 73  ? -14.627 -15.306 6.751   1.000 12.010 0 73  HIS A N   1 ? 
ATOM   538  C  CA  . HIS A 1 73  ? -15.741 -15.715 7.574   1.000 11.923 0 73  HIS A CA  1 ? 
ATOM   539  C  C   . HIS A 1 73  ? -16.649 -14.514 7.772   1.000 10.761 0 73  HIS A C   1 ? 
ATOM   540  O  O   . HIS A 1 73  ? -16.219 -13.396 8.047   1.000 11.408 0 73  HIS A O   1 ? 
ATOM   541  C  CB  . HIS A 1 73  ? -15.276 -16.241 8.937   1.000 12.804 0 73  HIS A CB  1 ? 
ATOM   542  C  CG  . HIS A 1 73  ? -16.355 -16.858 9.702   1.000 13.309 0 73  HIS A CG  1 ? 
ATOM   543  N  ND1 . HIS A 1 73  ? -17.247 -16.072 10.398  1.000 13.752 0 73  HIS A ND1 1 ? 
ATOM   544  C  CD2 . HIS A 1 73  ? -16.821 -18.111 9.698   1.000 13.920 0 73  HIS A CD2 1 ? 
ATOM   545  C  CE1 . HIS A 1 73  ? -18.164 -16.883 10.912  1.000 13.562 0 73  HIS A CE1 1 ? 
ATOM   546  N  NE2 . HIS A 1 73  ? -17.943 -18.132 10.471  1.000 15.082 0 73  HIS A NE2 1 ? 
ATOM   547  N  N   . PRO A 1 74  ? -17.982 -14.697 7.695   1.000 13.364 0 74  PRO A N   1 ? 
ATOM   548  C  CA  . PRO A 1 74  ? -18.857 -13.530 7.760   1.000 14.013 0 74  PRO A CA  1 ? 
ATOM   549  C  C   . PRO A 1 74  ? -18.899 -12.783 9.076   1.000 12.915 0 74  PRO A C   1 ? 
ATOM   550  O  O   . PRO A 1 74  ? -19.358 -11.639 9.067   1.000 15.479 0 74  PRO A O   1 ? 
ATOM   551  C  CB  . PRO A 1 74  ? -20.223 -14.150 7.401   1.000 15.860 0 74  PRO A CB  1 ? 
ATOM   552  C  CG  . PRO A 1 74  ? -20.097 -15.592 7.782   1.000 17.537 0 74  PRO A CG  1 ? 
ATOM   553  C  CD  . PRO A 1 74  ? -18.684 -15.921 7.278   1.000 14.828 0 74  PRO A CD  1 ? 
ATOM   554  N  N   . SER A 1 75  ? -18.392 -13.389 10.144  1.000 11.893 0 75  SER A N   1 ? 
ATOM   555  C  CA  . SER A 1 75  ? -18.352 -12.752 11.463  1.000 12.501 0 75  SER A CA  1 ? 
ATOM   556  C  C   . SER A 1 75  ? -16.923 -12.384 11.889  1.000 12.534 0 75  SER A C   1 ? 
ATOM   557  O  O   . SER A 1 75  ? -16.700 -12.112 13.074  1.000 12.099 0 75  SER A O   1 ? 
ATOM   558  C  CB  . SER A 1 75  ? -18.961 -13.628 12.511  1.000 16.572 0 75  SER A CB  1 ? 
ATOM   559  O  OG  . SER A 1 75  ? -20.322 -13.884 12.205  1.000 23.002 0 75  SER A OG  1 ? 
ATOM   560  N  N   . TYR A 1 76  ? -15.957 -12.419 10.970  1.000 12.219 0 76  TYR A N   1 ? 
ATOM   561  C  CA  . TYR A 1 76  ? -14.597 -12.073 11.331  1.000 11.144 0 76  TYR A CA  1 ? 
ATOM   562  C  C   . TYR A 1 76  ? -14.546 -10.653 11.876  1.000 14.230 0 76  TYR A C   1 ? 
ATOM   563  O  O   . TYR A 1 76  ? -15.083 -9.722  11.293  1.000 12.570 0 76  TYR A O   1 ? 
ATOM   564  C  CB  . TYR A 1 76  ? -13.686 -12.168 10.114  1.000 12.436 0 76  TYR A CB  1 ? 
ATOM   565  C  CG  . TYR A 1 76  ? -12.314 -11.602 10.319  1.000 11.954 0 76  TYR A CG  1 ? 
ATOM   566  C  CD1 . TYR A 1 76  ? -11.473 -12.088 11.313  1.000 13.590 0 76  TYR A CD1 1 ? 
ATOM   567  C  CD2 . TYR A 1 76  ? -11.878 -10.594 9.470   1.000 11.619 0 76  TYR A CD2 1 ? 
ATOM   568  C  CE1 . TYR A 1 76  ? -10.192 -11.564 11.455  1.000 12.265 0 76  TYR A CE1 1 ? 
ATOM   569  C  CE2 . TYR A 1 76  ? -10.614 -10.062 9.597   1.000 12.117 0 76  TYR A CE2 1 ? 
ATOM   570  C  CZ  . TYR A 1 76  ? -9.767  -10.597 10.569  1.000 12.396 0 76  TYR A CZ  1 ? 
ATOM   571  O  OH  . TYR A 1 76  ? -8.510  -10.116 10.825  1.000 13.997 0 76  TYR A OH  1 ? 
ATOM   572  N  N   . ASN A 1 77  ? -13.841 -10.493 12.983  1.000 13.348 0 77  ASN A N   1 ? 
ATOM   573  C  CA  . ASN A 1 77  ? -13.673 -9.200  13.631  1.000 14.466 0 77  ASN A CA  1 ? 
ATOM   574  C  C   . ASN A 1 77  ? -12.181 -8.935  13.670  1.000 12.959 0 77  ASN A C   1 ? 
ATOM   575  O  O   . ASN A 1 77  ? -11.491 -9.621  14.406  1.000 14.018 0 77  ASN A O   1 ? 
ATOM   576  C  CB  . ASN A 1 77  ? -14.279 -9.228  15.022  1.000 16.854 0 77  ASN A CB  1 ? 
ATOM   577  C  CG  . ASN A 1 77  ? -14.190 -7.901  15.715  1.000 21.058 0 77  ASN A CG  1 ? 
ATOM   578  O  OD1 . ASN A 1 77  ? -13.167 -7.228  15.618  1.000 19.825 0 77  ASN A OD1 1 ? 
ATOM   579  N  ND2 . ASN A 1 77  ? -15.243 -7.497  16.390  1.000 24.180 0 77  ASN A ND2 1 ? 
ATOM   580  N  N   . SER A 1 78  ? -11.685 -7.999  12.862  1.000 12.845 0 78  SER A N   1 ? 
ATOM   581  C  CA  . SER A 1 78  ? -10.256 -7.746  12.770  1.000 14.146 0 78  SER A CA  1 ? 
ATOM   582  C  C   . SER A 1 78  ? -9.685  -7.127  14.062  1.000 17.377 0 78  SER A C   1 ? 
ATOM   583  O  O   . SER A 1 78  ? -8.471  -7.204  14.292  1.000 18.159 0 78  SER A O   1 ? 
ATOM   584  C  CB  . SER A 1 78  ? -9.949  -6.912  11.568  1.000 17.438 0 78  SER A CB  1 ? 
ATOM   585  O  OG  . SER A 1 78  ? -10.629 -5.680  11.653  1.000 20.306 0 78  SER A OG  1 ? 
ATOM   586  N  N   . ASN A 1 79  ? -10.535 -6.555  14.904  1.000 15.549 0 79  ASN A N   1 ? 
ATOM   587  C  CA  . ASN A 1 79  ? -10.051 -5.964  16.136  1.000 15.617 0 79  ASN A CA  1 ? 
ATOM   588  C  C   . ASN A 1 79  ? -9.768  -7.012  17.210  1.000 17.985 0 79  ASN A C   1 ? 
ATOM   589  O  O   . ASN A 1 79  ? -8.722  -6.929  17.846  1.000 19.764 0 79  ASN A O   1 ? 
ATOM   590  C  CB  . ASN A 1 79  ? -11.024 -4.939  16.681  1.000 15.574 0 79  ASN A CB  1 ? 
ATOM   591  C  CG  . ASN A 1 79  ? -11.086 -3.757  15.757  1.000 16.108 0 79  ASN A CG  1 ? 
ATOM   592  O  OD1 . ASN A 1 79  ? -10.064 -3.341  15.199  1.000 20.079 0 79  ASN A OD1 1 ? 
ATOM   593  N  ND2 . ASN A 1 79  ? -12.269 -3.237  15.602  1.000 21.931 0 79  ASN A ND2 1 ? 
ATOM   594  N  N   . THR A 1 80  ? -10.629 -8.021  17.367  1.000 14.655 0 80  THR A N   1 ? 
ATOM   595  C  CA  . THR A 1 80  ? -10.467 -9.060  18.383  1.000 16.220 0 80  THR A CA  1 ? 
ATOM   596  C  C   . THR A 1 80  ? -9.909  -10.368 17.812  1.000 15.190 0 80  THR A C   1 ? 
ATOM   597  O  O   . THR A 1 80  ? -9.517  -11.240 18.598  1.000 17.545 0 80  THR A O   1 ? 
ATOM   598  C  CB  . THR A 1 80  ? -11.820 -9.365  19.009  1.000 18.412 0 80  THR A CB  1 ? 
ATOM   599  O  OG1 . THR A 1 80  ? -12.661 -9.855  17.970  1.000 17.731 0 80  THR A OG1 1 ? 
ATOM   600  C  CG2 . THR A 1 80  ? -12.494 -8.158  19.647  1.000 20.617 0 80  THR A CG2 1 ? 
ATOM   601  N  N   . LEU A 1 81  ? -9.900  -10.504 16.480  1.000 15.376 0 81  LEU A N   1 ? 
ATOM   602  C  CA  . LEU A 1 81  ? -9.457  -11.713 15.775  1.000 14.034 0 81  LEU A CA  1 ? 
ATOM   603  C  C   . LEU A 1 81  ? -10.427 -12.866 16.032  1.000 14.074 0 81  LEU A C   1 ? 
ATOM   604  O  O   . LEU A 1 81  ? -10.160 -14.003 15.707  1.000 13.912 0 81  LEU A O   1 ? 
ATOM   605  C  CB  . LEU A 1 81  ? -7.992  -12.064 16.027  1.000 15.605 0 81  LEU A CB  1 ? 
ATOM   606  C  CG  . LEU A 1 81  ? -6.988  -11.063 15.462  1.000 20.423 0 81  LEU A CG  1 ? 
ATOM   607  C  CD1 . LEU A 1 81  ? -5.598  -11.523 15.743  1.000 23.857 0 81  LEU A CD1 1 ? 
ATOM   608  C  CD2 . LEU A 1 81  ? -7.175  -10.924 13.981  1.000 22.019 0 81  LEU A CD2 1 ? 
ATOM   609  N  N   . ASN A 1 82  ? -11.638 -12.571 16.503  1.000 12.557 0 82  ASN A N   1 ? 
ATOM   610  C  CA  . ASN A 1 82  ? -12.665 -13.592 16.584  1.000 12.661 0 82  ASN A CA  1 ? 
ATOM   611  C  C   . ASN A 1 82  ? -13.075 -14.016 15.174  1.000 12.726 0 82  ASN A C   1 ? 
ATOM   612  O  O   . ASN A 1 82  ? -13.252 -13.168 14.304  1.000 12.278 0 82  ASN A O   1 ? 
ATOM   613  C  CB  . ASN A 1 82  ? -13.864 -13.060 17.346  1.000 13.248 0 82  ASN A CB  1 ? 
ATOM   614  C  CG  . ASN A 1 82  ? -14.788 -14.154 17.819  1.000 14.900 0 82  ASN A CG  1 ? 
ATOM   615  O  OD1 . ASN A 1 82  ? -14.407 -15.309 18.024  1.000 15.173 0 82  ASN A OD1 1 ? 
ATOM   616  N  ND2 . ASN A 1 82  ? -16.035 -13.779 18.000  1.000 18.265 0 82  ASN A ND2 1 ? 
ATOM   617  N  N   . ASN A 1 83  ? -13.210 -15.330 14.945  1.000 11.514 0 83  ASN A N   1 ? 
ATOM   618  C  CA  . ASN A 1 83  ? -13.576 -15.931 13.668  1.000 12.956 0 83  ASN A CA  1 ? 
ATOM   619  C  C   . ASN A 1 83  ? -12.500 -15.645 12.641  1.000 10.978 0 83  ASN A C   1 ? 
ATOM   620  O  O   . ASN A 1 83  ? -12.799 -15.315 11.487  1.000 10.465 0 83  ASN A O   1 ? 
ATOM   621  C  CB  . ASN A 1 83  ? -14.935 -15.495 13.131  1.000 12.521 0 83  ASN A CB  1 ? 
ATOM   622  C  CG  . ASN A 1 83  ? -16.010 -15.712 14.176  1.000 16.387 0 83  ASN A CG  1 ? 
ATOM   623  O  OD1 . ASN A 1 83  ? -16.270 -16.818 14.602  1.000 17.113 0 83  ASN A OD1 1 ? 
ATOM   624  N  ND2 . ASN A 1 83  ? -16.617 -14.641 14.636  1.000 16.382 0 83  ASN A ND2 1 ? 
ATOM   625  N  N   . ASP A 1 84  ? -11.229 -15.870 13.023  1.000 10.823 0 84  ASP A N   1 ? 
ATOM   626  C  CA  . ASP A 1 84  ? -10.088 -15.626 12.128  1.000 10.099 0 84  ASP A CA  1 ? 
ATOM   627  C  C   . ASP A 1 84  ? -9.877  -16.830 11.211  1.000 10.049 0 84  ASP A C   1 ? 
ATOM   628  O  O   . ASP A 1 84  ? -9.007  -17.665 11.449  1.000 11.098 0 84  ASP A O   1 ? 
ATOM   629  C  CB  . ASP A 1 84  ? -8.852  -15.246 12.934  1.000 10.178 0 84  ASP A CB  1 ? 
ATOM   630  C  CG  . ASP A 1 84  ? -7.684  -14.777 12.127  1.000 11.851 0 84  ASP A CG  1 ? 
ATOM   631  O  OD1 . ASP A 1 84  ? -7.918  -14.466 10.931  1.000 11.009 0 84  ASP A OD1 1 ? 
ATOM   632  O  OD2 . ASP A 1 84  ? -6.544  -14.752 12.717  1.000 12.422 0 84  ASP A OD2 1 ? 
ATOM   633  N  N   . ILE A 1 85  ? -10.678 -16.913 10.150  1.000 9.802  0 85  ILE A N   1 ? 
ATOM   634  C  CA  . ILE A 1 85  ? -10.675 -18.050 9.236   1.000 9.432  0 85  ILE A CA  1 ? 
ATOM   635  C  C   . ILE A 1 85  ? -11.137 -17.507 7.901   1.000 9.918  0 85  ILE A C   1 ? 
ATOM   636  O  O   . ILE A 1 85  ? -12.065 -16.708 7.809   1.000 10.213 0 85  ILE A O   1 ? 
ATOM   637  C  CB  . ILE A 1 85  ? -11.502 -19.254 9.748   1.000 10.043 0 85  ILE A CB  1 ? 
ATOM   638  C  CG1 . ILE A 1 85  ? -11.375 -20.428 8.816   1.000 11.857 0 85  ILE A CG1 1 ? 
ATOM   639  C  CG2 . ILE A 1 85  ? -12.968 -18.911 9.983   1.000 11.264 0 85  ILE A CG2 1 ? 
ATOM   640  C  CD1 . ILE A 1 85  ? -11.978 -21.708 9.378   1.000 13.681 0 85  ILE A CD1 1 ? 
ATOM   641  N  N   . MET A 1 86  ? -10.544 -18.059 6.844   1.000 10.471 0 86  MET A N   1 ? 
ATOM   642  C  CA  . MET A 1 86  ? -10.855 -17.686 5.465   1.000 10.653 0 86  MET A CA  1 ? 
ATOM   643  C  C   . MET A 1 86  ? -10.693 -18.921 4.601   1.000 10.490 0 86  MET A C   1 ? 
ATOM   644  O  O   . MET A 1 86  ? -9.884  -19.798 4.940   1.000 11.333 0 86  MET A O   1 ? 
ATOM   645  C  CB  . MET A 1 86  ? -9.896  -16.579 4.993   1.000 15.017 0 86  MET A CB  1 ? 
ATOM   646  C  CG  . MET A 1 86  ? -9.626  -16.461 3.574   1.000 21.454 0 86  MET A CG  1 ? 
ATOM   647  S  SD  . MET A 1 86  ? -8.478  -15.063 3.447   1.000 20.143 0 86  MET A SD  1 ? 
ATOM   648  C  CE  . MET A 1 86  ? -6.825  -15.688 3.642   1.000 20.522 0 86  MET A CE  1 ? 
ATOM   649  N  N   . LEU A 1 87  ? -11.509 -19.028 3.562   1.000 10.206 0 87  LEU A N   1 ? 
ATOM   650  C  CA  . LEU A 1 87  ? -11.345 -20.047 2.537   1.000 11.199 0 87  LEU A CA  1 ? 
ATOM   651  C  C   . LEU A 1 87  ? -10.837 -19.439 1.240   1.000 10.358 0 87  LEU A C   1 ? 
ATOM   652  O  O   . LEU A 1 87  ? -11.239 -18.352 0.840   1.000 14.007 0 87  LEU A O   1 ? 
ATOM   653  C  CB  . LEU A 1 87  ? -12.694 -20.713 2.281   1.000 12.347 0 87  LEU A CB  1 ? 
ATOM   654  C  CG  . LEU A 1 87  ? -13.214 -21.592 3.414   1.000 15.140 0 87  LEU A CG  1 ? 
ATOM   655  C  CD1 . LEU A 1 87  ? -14.708 -21.927 3.304   1.000 18.182 0 87  LEU A CD1 1 ? 
ATOM   656  C  CD2 . LEU A 1 87  ? -12.417 -22.878 3.462   1.000 18.530 0 87  LEU A CD2 1 ? 
ATOM   657  N  N   . ILE A 1 88  ? -9.983  -20.185 0.551   1.000 10.377 0 88  ILE A N   1 ? 
ATOM   658  C  CA  . ILE A 1 88  ? -9.436  -19.713 -0.715  1.000 10.926 0 88  ILE A CA  1 ? 
ATOM   659  C  C   . ILE A 1 88  ? -9.712  -20.832 -1.703  1.000 11.660 0 88  ILE A C   1 ? 
ATOM   660  O  O   . ILE A 1 88  ? -9.335  -21.943 -1.470  1.000 14.751 0 88  ILE A O   1 ? 
ATOM   661  C  CB  . ILE A 1 88  ? -7.927  -19.445 -0.586  1.000 12.551 0 88  ILE A CB  1 ? 
ATOM   662  C  CG1 . ILE A 1 88  ? -7.590  -18.403 0.473   1.000 14.793 0 88  ILE A CG1 1 ? 
ATOM   663  C  CG2 . ILE A 1 88  ? -7.319  -19.076 -1.941  1.000 15.334 0 88  ILE A CG2 1 ? 
ATOM   664  C  CD1 . ILE A 1 88  ? -6.113  -18.344 0.817   1.000 15.992 0 88  ILE A CD1 1 ? 
ATOM   665  N  N   . LYS A 1 89  ? -10.345 -20.500 -2.808  1.000 11.417 0 89  LYS A N   1 ? 
ATOM   666  C  CA  . LYS A 1 89  ? -10.529 -21.460 -3.874  1.000 13.578 0 89  LYS A CA  1 ? 
ATOM   667  C  C   . LYS A 1 89  ? -9.458  -21.274 -4.932  1.000 13.905 0 89  LYS A C   1 ? 
ATOM   668  O  O   . LYS A 1 89  ? -9.205  -20.159 -5.362  1.000 16.115 0 89  LYS A O   1 ? 
ATOM   669  C  CB  . LYS A 1 89  ? -11.891 -21.266 -4.537  1.000 15.493 0 89  LYS A CB  1 ? 
ATOM   670  C  CG  . LYS A 1 89  ? -12.193 -22.517 -5.366  1.000 17.791 0 89  LYS A CG  1 ? 
ATOM   671  C  CD  . LYS A 1 89  ? -13.571 -22.484 -5.992  1.000 21.172 0 89  LYS A CD  1 ? 
ATOM   672  C  CE  . LYS A 1 89  ? -13.908 -23.735 -6.754  1.000 22.026 0 89  LYS A CE  1 ? 
ATOM   673  N  NZ  . LYS A 1 89  ? -15.041 -23.464 -7.664  1.000 25.470 0 89  LYS A NZ  1 ? 
ATOM   674  N  N   . LEU A 1 90  ? -8.906  -22.384 -5.393  1.000 15.026 0 90  LEU A N   1 ? 
ATOM   675  C  CA  . LEU A 1 90  ? -7.876  -22.377 -6.431  1.000 18.169 0 90  LEU A CA  1 ? 
ATOM   676  C  C   . LEU A 1 90  ? -8.536  -22.317 -7.811  1.000 17.120 0 90  LEU A C   1 ? 
ATOM   677  O  O   . LEU A 1 90  ? -9.626  -22.891 -7.987  1.000 18.127 0 90  LEU A O   1 ? 
ATOM   678  C  CB  . LEU A 1 90  ? -7.080  -23.664 -6.284  1.000 18.633 0 90  LEU A CB  1 ? 
ATOM   679  C  CG  . LEU A 1 90  ? -6.417  -23.924 -4.920  1.000 21.927 0 90  LEU A CG  1 ? 
ATOM   680  C  CD1 . LEU A 1 90  ? -5.705  -25.251 -4.971  1.000 22.052 0 90  LEU A CD1 1 ? 
ATOM   681  C  CD2 . LEU A 1 90  ? -5.463  -22.813 -4.566  1.000 25.493 0 90  LEU A CD2 1 ? 
ATOM   682  N  N   . LYS A 1 91  ? -7.885  -21.652 -8.760  1.000 18.474 0 91  LYS A N   1 ? 
ATOM   683  C  CA  . LYS A 1 91  ? -8.392  -21.504 -10.128 1.000 22.427 0 91  LYS A CA  1 ? 
ATOM   684  C  C   . LYS A 1 91  ? -8.480  -22.856 -10.828 1.000 24.409 0 91  LYS A C   1 ? 
ATOM   685  O  O   . LYS A 1 91  ? -9.350  -23.078 -11.681 1.000 24.388 0 91  LYS A O   1 ? 
ATOM   686  C  CB  . LYS A 1 91  ? -7.507  -20.540 -10.935 1.000 26.789 0 91  LYS A CB  1 ? 
ATOM   687  C  CG  . LYS A 1 91  ? -7.884  -19.068 -10.811 1.000 32.660 0 91  LYS A CG  1 ? 
ATOM   688  C  CD  . LYS A 1 91  ? -7.175  -18.154 -11.815 1.000 37.189 0 91  LYS A CD  1 ? 
ATOM   689  C  CE  . LYS A 1 91  ? -7.660  -16.735 -11.698 1.000 42.561 0 91  LYS A CE  1 ? 
ATOM   690  N  NZ  . LYS A 1 91  ? -6.766  -15.753 -12.307 1.000 49.030 0 91  LYS A NZ  1 ? 
ATOM   691  N  N   . SER A 1 92  ? -7.558  -23.771 -10.522 1.000 21.892 0 92  SER A N   1 ? 
ATOM   692  C  CA  . SER A 1 92  ? -7.621  -25.134 -11.001 1.000 22.343 0 92  SER A CA  1 ? 
ATOM   693  C  C   . SER A 1 92  ? -7.244  -26.081 -9.859  1.000 25.060 0 92  SER A C   1 ? 
ATOM   694  O  O   . SER A 1 92  ? -6.613  -25.681 -8.875  1.000 22.095 0 92  SER A O   1 ? 
ATOM   695  C  CB  . SER A 1 92  ? -6.718  -25.336 -12.185 1.000 29.418 0 92  SER A CB  1 ? 
ATOM   696  O  OG  . SER A 1 92  ? -5.379  -25.074 -11.800 1.000 33.889 0 92  SER A OG  1 ? 
ATOM   697  N  N   . ALA A 1 93  ? -7.672  -27.333 -9.975  1.000 21.455 0 93  ALA A N   1 ? 
ATOM   698  C  CA  . ALA A 1 93  ? -7.469  -28.321 -8.944  1.000 21.565 0 93  ALA A CA  1 ? 
ATOM   699  C  C   . ALA A 1 93  ? -5.990  -28.652 -8.864  1.000 21.321 0 93  ALA A C   1 ? 
ATOM   700  O  O   . ALA A 1 93  ? -5.336  -28.789 -9.891  1.000 23.408 0 93  ALA A O   1 ? 
ATOM   701  C  CB  . ALA A 1 93  ? -8.265  -29.558 -9.265  1.000 22.485 0 93  ALA A CB  1 ? 
ATOM   702  N  N   . ALA A 1 94  ? -5.507  -28.818 -7.637  1.000 19.152 0 94  ALA A N   1 ? 
ATOM   703  C  CA  . ALA A 1 94  ? -4.187  -29.373 -7.387  1.000 20.991 0 94  ALA A CA  1 ? 
ATOM   704  C  C   . ALA A 1 94  ? -4.157  -30.851 -7.785  1.000 22.570 0 94  ALA A C   1 ? 
ATOM   705  O  O   . ALA A 1 94  ? -5.190  -31.524 -7.790  1.000 19.816 0 94  ALA A O   1 ? 
ATOM   706  C  CB  . ALA A 1 94  ? -3.860  -29.209 -5.926  1.000 23.915 0 94  ALA A CB  1 ? 
ATOM   707  N  N   . SER A 1 95  ? -2.968  -31.322 -8.169  1.000 22.486 0 95  SER A N   1 ? 
ATOM   708  C  CA  . SER A 1 95  ? -2.705  -32.747 -8.360  1.000 25.545 0 95  SER A CA  1 ? 
ATOM   709  C  C   . SER A 1 95  ? -2.191  -33.323 -7.059  1.000 24.979 0 95  SER A C   1 ? 
ATOM   710  O  O   . SER A 1 95  ? -1.104  -32.939 -6.606  1.000 27.159 0 95  SER A O   1 ? 
ATOM   711  C  CB  . SER A 1 95  ? -1.682  -33.023 -9.447  1.000 31.794 0 95  SER A CB  1 ? 
ATOM   712  O  OG  . SER A 1 95  ? -2.189  -32.607 -10.700 1.000 37.613 0 95  SER A OG  1 ? 
ATOM   713  N  N   . LEU A 1 96  ? -2.979  -34.224 -6.462  1.000 22.899 0 96  LEU A N   1 ? 
ATOM   714  C  CA  . LEU A 1 96  ? -2.675  -34.765 -5.157  1.000 24.995 0 96  LEU A CA  1 ? 
ATOM   715  C  C   . LEU A 1 96  ? -1.743  -35.953 -5.368  1.000 31.449 0 96  LEU A C   1 ? 
ATOM   716  O  O   . LEU A 1 96  ? -1.959  -36.717 -6.311  1.000 31.247 0 96  LEU A O   1 ? 
ATOM   717  C  CB  . LEU A 1 96  ? -3.957  -35.141 -4.434  1.000 26.765 0 96  LEU A CB  1 ? 
ATOM   718  C  CG  . LEU A 1 96  ? -4.925  -33.989 -4.175  1.000 31.402 0 96  LEU A CG  1 ? 
ATOM   719  C  CD1 . LEU A 1 96  ? -6.085  -34.453 -3.296  1.000 37.493 0 96  LEU A CD1 1 ? 
ATOM   720  C  CD2 . LEU A 1 96  ? -4.230  -32.821 -3.507  1.000 32.866 0 96  LEU A CD2 1 ? 
ATOM   721  N  N   . ASN A 1 97  ? -0.677  -36.009 -4.567  1.000 28.357 0 97  ASN A N   1 ? 
ATOM   722  C  CA  . ASN A 1 97  ? 0.372   -37.029 -4.641  1.000 34.569 0 97  ASN A CA  1 ? 
ATOM   723  C  C   . ASN A 1 97  ? 0.969   -37.202 -3.234  1.000 35.653 0 97  ASN A C   1 ? 
ATOM   724  O  O   . ASN A 1 97  ? 0.346   -36.822 -2.246  1.000 37.472 0 97  ASN A O   1 ? 
ATOM   725  C  CB  . ASN A 1 97  ? 1.367   -36.724 -5.770  1.000 35.577 0 97  ASN A CB  1 ? 
ATOM   726  C  CG  . ASN A 1 97  ? 1.982   -35.336 -5.740  1.000 40.096 0 97  ASN A CG  1 ? 
ATOM   727  O  OD1 . ASN A 1 97  ? 1.984   -34.619 -6.748  1.000 42.819 0 97  ASN A OD1 1 ? 
ATOM   728  N  ND2 . ASN A 1 97  ? 2.605   -34.957 -4.644  1.000 41.314 0 97  ASN A ND2 1 ? 
ATOM   729  N  N   . SER A 1 98  ? 2.167   -37.782 -3.097  1.000 36.225 0 98  SER A N   1 ? 
ATOM   730  C  CA  . SER A 1 98  ? 2.711   -37.991 -1.765  1.000 37.740 0 98  SER A CA  1 ? 
ATOM   731  C  C   . SER A 1 98  ? 3.256   -36.680 -1.180  1.000 36.025 0 98  SER A C   1 ? 
ATOM   732  O  O   . SER A 1 98  ? 3.355   -36.553 0.039   1.000 37.991 0 98  SER A O   1 ? 
ATOM   733  C  CB  . SER A 1 98  ? 3.749   -39.088 -1.763  1.000 38.122 0 98  SER A CB  1 ? 
ATOM   734  O  OG  . SER A 1 98  ? 4.903   -38.653 -2.459  1.000 42.383 0 98  SER A OG  1 ? 
ATOM   735  N  N   . ARG A 1 99  ? 3.588   -35.699 -2.039  1.000 31.974 0 99  ARG A N   1 ? 
ATOM   736  C  CA  . ARG A 1 99  ? 4.146   -34.419 -1.611  1.000 29.851 0 99  ARG A CA  1 ? 
ATOM   737  C  C   . ARG A 1 99  ? 3.080   -33.331 -1.441  1.000 26.969 0 99  ARG A C   1 ? 
ATOM   738  O  O   . ARG A 1 99  ? 3.315   -32.300 -0.799  1.000 29.049 0 99  ARG A O   1 ? 
ATOM   739  C  CB  . ARG A 1 99  ? 5.180   -34.007 -2.663  1.000 37.608 0 99  ARG A CB  1 ? 
ATOM   740  C  CG  . ARG A 1 99  ? 6.318   -35.017 -2.649  1.000 46.984 0 99  ARG A CG  1 ? 
ATOM   741  C  CD  . ARG A 1 99  ? 7.521   -34.601 -3.465  1.000 58.095 0 99  ARG A CD  1 ? 
ATOM   742  N  NE  . ARG A 1 99  ? 8.679   -35.476 -3.233  1.000 65.626 0 99  ARG A NE  1 ? 
ATOM   743  C  CZ  . ARG A 1 99  ? 8.779   -36.736 -3.645  1.000 74.962 0 99  ARG A CZ  1 ? 
ATOM   744  N  NH1 . ARG A 1 99  ? 7.794   -37.297 -4.332  1.000 75.787 0 99  ARG A NH1 1 ? 
ATOM   745  N  NH2 . ARG A 1 99  ? 9.874   -37.430 -3.382  1.000 74.192 0 99  ARG A NH2 1 ? 
ATOM   746  N  N   . VAL A 1 100 ? 1.910   -33.548 -2.047  1.000 20.786 0 100 VAL A N   1 ? 
ATOM   747  C  CA  . VAL A 1 100 ? 0.817   -32.594 -1.984  1.000 18.807 0 100 VAL A CA  1 ? 
ATOM   748  C  C   . VAL A 1 100 ? -0.438  -33.398 -1.689  1.000 21.535 0 100 VAL A C   1 ? 
ATOM   749  O  O   . VAL A 1 100 ? -0.822  -34.262 -2.471  1.000 22.193 0 100 VAL A O   1 ? 
ATOM   750  C  CB  . VAL A 1 100 ? 0.688   -31.807 -3.283  1.000 17.508 0 100 VAL A CB  1 ? 
ATOM   751  C  CG1 . VAL A 1 100 ? -0.587  -30.981 -3.319  1.000 20.263 0 100 VAL A CG1 1 ? 
ATOM   752  C  CG2 . VAL A 1 100 ? 1.913   -30.944 -3.556  1.000 17.904 0 100 VAL A CG2 1 ? 
ATOM   753  N  N   . ALA A 1 101 ? -1.002  -33.176 -0.502  1.000 17.730 0 101 ALA A N   1 ? 
ATOM   754  C  CA  . ALA A 1 101 ? -2.101  -33.989 -0.020  1.000 17.292 0 101 ALA A CA  1 ? 
ATOM   755  C  C   . ALA A 1 101 ? -2.966  -33.118 0.873   1.000 17.774 0 101 ALA A C   1 ? 
ATOM   756  O  O   . ALA A 1 101 ? -2.460  -32.186 1.470   1.000 18.093 0 101 ALA A O   1 ? 
ATOM   757  C  CB  . ALA A 1 101 ? -1.554  -35.166 0.738   1.000 18.076 0 101 ALA A CB  1 ? 
ATOM   758  N  N   . SER A 1 102 ? -4.251  -33.468 0.979   1.000 16.738 0 102 SER A N   1 ? 
ATOM   759  C  CA  . SER A 1 102 ? -5.181  -32.720 1.795   1.000 16.661 0 102 SER A CA  1 ? 
ATOM   760  C  C   . SER A 1 102 ? -5.177  -33.231 3.222   1.000 17.252 0 102 SER A C   1 ? 
ATOM   761  O  O   . SER A 1 102 ? -4.734  -34.342 3.518   1.000 18.184 0 102 SER A O   1 ? 
ATOM   762  C  CB  . SER A 1 102 ? -6.559  -32.770 1.199   1.000 20.554 0 102 SER A CB  1 ? 
ATOM   763  O  OG  . SER A 1 102 ? -6.979  -34.112 1.136   1.000 25.919 0 102 SER A OG  1 ? 
ATOM   764  N  N   . ILE A 1 103 ? -5.582  -32.353 4.150   1.000 15.312 0 103 ILE A N   1 ? 
ATOM   765  C  CA  . ILE A 1 103 ? -5.722  -32.702 5.550   1.000 15.485 0 103 ILE A CA  1 ? 
ATOM   766  C  C   . ILE A 1 103 ? -7.213  -32.722 5.866   1.000 15.527 0 103 ILE A C   1 ? 
ATOM   767  O  O   . ILE A 1 103 ? -8.005  -31.939 5.324   1.000 18.595 0 103 ILE A O   1 ? 
ATOM   768  C  CB  . ILE A 1 103 ? -4.959  -31.736 6.476   1.000 16.165 0 103 ILE A CB  1 ? 
ATOM   769  C  CG1 . ILE A 1 103 ? -5.008  -32.163 7.934   1.000 19.336 0 103 ILE A CG1 1 ? 
ATOM   770  C  CG2 . ILE A 1 103 ? -5.513  -30.327 6.388   1.000 17.560 0 103 ILE A CG2 1 ? 
ATOM   771  C  CD1 . ILE A 1 103 ? -4.121  -33.326 8.281   1.000 22.557 0 103 ILE A CD1 1 ? 
ATOM   772  N  N   . SER A 1 104 ? -7.610  -33.682 6.700   1.000 17.182 0 104 SER A N   1 ? 
ATOM   773  C  CA  . SER A 1 104 ? -9.009  -33.848 7.061   1.000 19.958 0 104 SER A CA  1 ? 
ATOM   774  C  C   . SER A 1 104 ? -9.465  -32.767 8.030   1.000 17.608 0 104 SER A C   1 ? 
ATOM   775  O  O   . SER A 1 104 ? -8.728  -32.421 8.960   1.000 16.441 0 104 SER A O   1 ? 
ATOM   776  C  CB  . SER A 1 104 ? -9.212  -35.194 7.696   1.000 23.925 0 104 SER A CB  1 ? 
ATOM   777  O  OG  . SER A 1 104 ? -8.872  -36.198 6.756   1.000 32.449 0 104 SER A OG  1 ? 
ATOM   778  N  N   . LEU A 1 105 ? -10.739 -32.380 7.897   1.000 17.607 0 105 LEU A N   1 ? 
ATOM   779  C  CA  . LEU A 1 105 ? -11.394 -31.574 8.917   1.000 15.325 0 105 LEU A CA  1 ? 
ATOM   780  C  C   . LEU A 1 105 ? -11.821 -32.441 10.099  1.000 18.314 0 105 LEU A C   1 ? 
ATOM   781  O  O   . LEU A 1 105 ? -12.108 -33.637 9.944   1.000 19.052 0 105 LEU A O   1 ? 
ATOM   782  C  CB  . LEU A 1 105 ? -12.616 -30.914 8.287   1.000 17.816 0 105 LEU A CB  1 ? 
ATOM   783  C  CG  . LEU A 1 105 ? -12.312 -29.863 7.212   1.000 20.957 0 105 LEU A CG  1 ? 
ATOM   784  C  CD1 . LEU A 1 105 ? -13.636 -29.392 6.641   1.000 25.062 0 105 LEU A CD1 1 ? 
ATOM   785  C  CD2 . LEU A 1 105 ? -11.527 -28.700 7.831   1.000 22.821 0 105 LEU A CD2 1 ? 
ATOM   786  N  N   . PRO A 1 106 ? -11.903 -31.861 11.312  1.000 17.339 0 106 PRO A N   1 ? 
ATOM   787  C  CA  . PRO A 1 106 ? -12.301 -32.595 12.513  1.000 19.690 0 106 PRO A CA  1 ? 
ATOM   788  C  C   . PRO A 1 106 ? -13.809 -32.834 12.562  1.000 22.633 0 106 PRO A C   1 ? 
ATOM   789  O  O   . PRO A 1 106 ? -14.563 -32.043 12.027  1.000 23.033 0 106 PRO A O   1 ? 
ATOM   790  C  CB  . PRO A 1 106 ? -11.828 -31.676 13.632  1.000 20.131 0 106 PRO A CB  1 ? 
ATOM   791  C  CG  . PRO A 1 106 ? -11.994 -30.298 13.058  1.000 20.338 0 106 PRO A CG  1 ? 
ATOM   792  C  CD  . PRO A 1 106 ? -11.650 -30.437 11.586  1.000 19.243 0 106 PRO A CD  1 ? 
ATOM   793  N  N   . THR A 1 107 ? -14.229 -33.961 13.151  1.000 26.939 0 107 THR A N   1 ? 
ATOM   794  C  CA  . THR A 1 107 ? -15.638 -34.175 13.431  1.000 31.154 0 107 THR A CA  1 ? 
ATOM   795  C  C   . THR A 1 107 ? -15.887 -33.773 14.875  1.000 30.813 0 107 THR A C   1 ? 
ATOM   796  O  O   . THR A 1 107 ? -17.019 -33.518 15.267  1.000 38.406 0 107 THR A O   1 ? 
ATOM   797  C  CB  . THR A 1 107 ? -16.037 -35.630 13.193  1.000 36.041 0 107 THR A CB  1 ? 
ATOM   798  O  OG1 . THR A 1 107 ? -15.204 -36.407 14.048  1.000 35.994 0 107 THR A OG1 1 ? 
ATOM   799  C  CG2 . THR A 1 107 ? -15.832 -36.073 11.760  1.000 38.004 0 107 THR A CG2 1 ? 
ATOM   800  N  N   . SER A 1 108 ? -14.796 -33.677 15.621  1.000 28.211 0 108 SER A N   1 ? 
ATOM   801  C  CA  . SER A 1 108 ? -14.793 -33.519 17.052  1.000 30.032 0 108 SER A CA  1 ? 
ATOM   802  C  C   . SER A 1 108 ? -13.698 -32.517 17.419  1.000 28.020 0 108 SER A C   1 ? 
ATOM   803  O  O   . SER A 1 108 ? -12.700 -32.448 16.725  1.000 25.166 0 108 SER A O   1 ? 
ATOM   804  C  CB  . SER A 1 108 ? -14.565 -34.888 17.638  1.000 35.213 0 108 SER A CB  1 ? 
ATOM   805  O  OG  . SER A 1 108 ? -14.096 -34.849 18.967  1.000 41.862 0 108 SER A OG  1 ? 
ATOM   806  N  N   . CYS A 1 109 ? -13.889 -31.752 18.493  1.000 23.910 0 109 CYS A N   1 ? 
ATOM   807  C  CA  . CYS A 1 109 ? -12.873 -30.826 18.970  1.000 22.384 0 109 CYS A CA  1 ? 
ATOM   808  C  C   . CYS A 1 109 ? -11.784 -31.585 19.719  1.000 25.973 0 109 CYS A C   1 ? 
ATOM   809  O  O   . CYS A 1 109 ? -12.011 -32.651 20.286  1.000 27.434 0 109 CYS A O   1 ? 
ATOM   810  C  CB  . CYS A 1 109 ? -13.491 -29.735 19.835  1.000 23.459 0 109 CYS A CB  1 ? 
ATOM   811  S  SG  . CYS A 1 109 ? -14.743 -28.772 18.945  1.000 21.590 0 109 CYS A SG  1 ? 
ATOM   812  N  N   . ALA A 1 110 ? -10.570 -31.068 19.677  1.000 21.877 0 110 ALA A N   1 ? 
ATOM   813  C  CA  . ALA A 1 110 ? -9.466  -31.749 20.318  1.000 24.371 0 110 ALA A CA  1 ? 
ATOM   814  C  C   . ALA A 1 110 ? -9.463  -31.437 21.815  1.000 25.799 0 110 ALA A C   1 ? 
ATOM   815  O  O   . ALA A 1 110 ? -9.991  -30.403 22.225  1.000 28.740 0 110 ALA A O   1 ? 
ATOM   816  C  CB  . ALA A 1 110 ? -8.181  -31.339 19.669  1.000 28.288 0 110 ALA A CB  1 ? 
ATOM   817  N  N   . SER A 1 111 ? -8.872  -32.360 22.592  1.000 25.217 0 111 SER A N   1 ? 
ATOM   818  C  CA  . SER A 1 111 ? -8.812  -32.286 24.043  1.000 28.200 0 111 SER A CA  1 ? 
ATOM   819  C  C   . SER A 1 111 ? -7.575  -31.532 24.530  1.000 22.047 0 111 SER A C   1 ? 
ATOM   820  O  O   . SER A 1 111 ? -6.501  -31.659 23.976  1.000 21.199 0 111 SER A O   1 ? 
ATOM   821  C  CB  . SER A 1 111 ? -8.823  -33.686 24.639  1.000 31.662 0 111 SER A CB  1 ? 
ATOM   822  O  OG  . SER A 1 111 ? -10.048 -34.355 24.349  1.000 38.710 0 111 SER A OG  1 ? 
ATOM   823  N  N   . ALA A 1 112 ? -7.704  -30.858 25.667  1.000 21.259 0 112 ALA A N   1 ? 
ATOM   824  C  CA  . ALA A 1 112 ? -6.572  -30.349 26.418  1.000 19.660 0 112 ALA A CA  1 ? 
ATOM   825  C  C   . ALA A 1 112 ? -5.521  -31.430 26.607  1.000 21.348 0 112 ALA A C   1 ? 
ATOM   826  O  O   . ALA A 1 112 ? -5.842  -32.610 26.841  1.000 21.875 0 112 ALA A O   1 ? 
ATOM   827  C  CB  . ALA A 1 112 ? -7.033  -29.832 27.768  1.000 23.517 0 112 ALA A CB  1 ? 
ATOM   828  N  N   . GLY A 1 113 ? -4.255  -31.037 26.457  1.000 17.995 0 113 GLY A N   1 ? 
ATOM   829  C  CA  . GLY A 1 113 ? -3.150  -31.968 26.608  1.000 20.964 0 113 GLY A CA  1 ? 
ATOM   830  C  C   . GLY A 1 113 ? -2.745  -32.715 25.342  1.000 22.939 0 113 GLY A C   1 ? 
ATOM   831  O  O   . GLY A 1 113 ? -1.726  -33.400 25.371  1.000 24.328 0 113 GLY A O   1 ? 
ATOM   832  N  N   . THR A 1 114 ? -3.580  -32.667 24.288  1.000 19.407 0 114 THR A N   1 ? 
ATOM   833  C  CA  . THR A 1 114 ? -3.285  -33.290 23.012  1.000 20.327 0 114 THR A CA  1 ? 
ATOM   834  C  C   . THR A 1 114 ? -2.099  -32.583 22.397  1.000 18.700 0 114 THR A C   1 ? 
ATOM   835  O  O   . THR A 1 114 ? -2.049  -31.347 22.389  1.000 17.767 0 114 THR A O   1 ? 
ATOM   836  C  CB  . THR A 1 114 ? -4.490  -33.246 22.081  1.000 20.734 0 114 THR A CB  1 ? 
ATOM   837  O  OG1 . THR A 1 114 ? -5.511  -33.983 22.745  1.000 25.340 0 114 THR A OG1 1 ? 
ATOM   838  C  CG2 . THR A 1 114 ? -4.197  -33.959 20.780  1.000 21.900 0 114 THR A CG2 1 ? 
ATOM   839  N  N   . GLN A 1 115 ? -1.171  -33.401 21.884  1.000 18.798 0 115 GLN A N   1 ? 
ATOM   840  C  CA  . GLN A 1 115 ? 0.012   -32.866 21.232  1.000 20.558 0 115 GLN A CA  1 ? 
ATOM   841  C  C   . GLN A 1 115 ? -0.345  -32.636 19.769  1.000 16.847 0 115 GLN A C   1 ? 
ATOM   842  O  O   . GLN A 1 115 ? -1.031  -33.425 19.132  1.000 20.103 0 115 GLN A O   1 ? 
ATOM   843  C  CB  . GLN A 1 115 ? 1.227   -33.797 21.333  1.000 24.679 0 115 GLN A CB  1 ? 
ATOM   844  C  CG  . GLN A 1 115 ? 1.798   -33.926 22.737  1.000 31.103 0 115 GLN A CG  1 ? 
ATOM   845  C  CD  . GLN A 1 115 ? 2.630   -32.738 23.164  1.000 36.863 0 115 GLN A CD  1 ? 
ATOM   846  O  OE1 . GLN A 1 115 ? 3.115   -31.936 22.355  1.000 45.664 0 115 GLN A OE1 1 ? 
ATOM   847  N  NE2 . GLN A 1 115 ? 2.791   -32.611 24.471  1.000 47.927 0 115 GLN A NE2 1 ? 
ATOM   848  N  N   . CYS A 1 116 ? 0.003   -31.465 19.264  1.000 15.187 0 116 CYS A N   1 ? 
ATOM   849  C  CA  . CYS A 1 116 ? -0.349  -31.050 17.929  1.000 14.513 0 116 CYS A CA  1 ? 
ATOM   850  C  C   . CYS A 1 116 ? 0.912   -30.638 17.184  1.000 14.898 0 116 CYS A C   1 ? 
ATOM   851  O  O   . CYS A 1 116 ? 1.888   -30.291 17.810  1.000 17.275 0 116 CYS A O   1 ? 
ATOM   852  C  CB  . CYS A 1 116 ? -1.271  -29.843 17.922  1.000 15.986 0 116 CYS A CB  1 ? 
ATOM   853  S  SG  . CYS A 1 116 ? -2.786  -30.197 18.852  1.000 18.966 0 116 CYS A SG  1 ? 
ATOM   854  N  N   . LEU A 1 117 ? 0.844   -30.671 15.852  1.000 12.299 0 117 LEU A N   1 ? 
ATOM   855  C  CA  . LEU A 1 117 ? 1.943   -30.247 15.014  1.000 11.600 0 117 LEU A CA  1 ? 
ATOM   856  C  C   . LEU A 1 117 ? 1.571   -28.929 14.316  1.000 11.721 0 117 LEU A C   1 ? 
ATOM   857  O  O   . LEU A 1 117 ? 0.545   -28.851 13.635  1.000 12.982 0 117 LEU A O   1 ? 
ATOM   858  C  CB  . LEU A 1 117 ? 2.228   -31.329 13.981  1.000 14.302 0 117 LEU A CB  1 ? 
ATOM   859  C  CG  . LEU A 1 117 ? 3.319   -31.022 12.942  1.000 16.466 0 117 LEU A CG  1 ? 
ATOM   860  C  CD1 . LEU A 1 117 ? 4.680   -31.159 13.592  1.000 19.703 0 117 LEU A CD1 1 ? 
ATOM   861  C  CD2 . LEU A 1 117 ? 3.198   -31.920 11.764  1.000 19.845 0 117 LEU A CD2 1 ? 
ATOM   862  N  N   . ILE A 1 118 ? 2.437   -27.939 14.543  1.000 11.943 0 118 ILE A N   1 ? 
ATOM   863  C  CA  . ILE A 1 118 ? 2.298   -26.608 13.982  1.000 12.669 0 118 ILE A CA  1 ? 
ATOM   864  C  C   . ILE A 1 118 ? 3.477   -26.405 13.052  1.000 12.260 0 118 ILE A C   1 ? 
ATOM   865  O  O   . ILE A 1 118 ? 4.598   -26.789 13.373  1.000 12.925 0 118 ILE A O   1 ? 
ATOM   866  C  CB  . ILE A 1 118 ? 2.281   -25.567 15.097  1.000 14.072 0 118 ILE A CB  1 ? 
ATOM   867  C  CG1 . ILE A 1 118 ? 1.232   -25.982 16.148  1.000 16.405 0 118 ILE A CG1 1 ? 
ATOM   868  C  CG2 . ILE A 1 118 ? 2.051   -24.165 14.496  1.000 15.480 0 118 ILE A CG2 1 ? 
ATOM   869  C  CD1 . ILE A 1 118 ? 1.211   -25.158 17.412  1.000 19.934 0 118 ILE A CD1 1 ? 
ATOM   870  N  N   . SER A 1 119 ? 3.241   -25.791 11.890  1.000 11.256 0 119 SER A N   1 ? 
ATOM   871  C  CA  . SER A 1 119 ? 4.286   -25.661 10.902  1.000 10.879 0 119 SER A CA  1 ? 
ATOM   872  C  C   . SER A 1 119 ? 4.188   -24.339 10.152  1.000 10.940 0 119 SER A C   1 ? 
ATOM   873  O  O   . SER A 1 119 ? 3.157   -23.708 10.081  1.000 11.321 0 119 SER A O   1 ? 
ATOM   874  C  CB  . SER A 1 119 ? 4.229   -26.786 9.923   1.000 12.082 0 119 SER A CB  1 ? 
ATOM   875  O  OG  . SER A 1 119 ? 2.931   -26.996 9.360   1.000 13.361 0 119 SER A OG  1 ? 
ATOM   876  N  N   . GLY A 1 120 ? 5.340   -23.908 9.642   1.000 10.761 0 120 GLY A N   1 ? 
ATOM   877  C  CA  . GLY A 1 120 ? 5.378   -22.735 8.816   1.000 10.758 0 120 GLY A CA  1 ? 
ATOM   878  C  C   . GLY A 1 120 ? 6.763   -22.182 8.568   1.000 11.231 0 120 GLY A C   1 ? 
ATOM   879  O  O   . GLY A 1 120 ? 7.765   -22.676 9.086   1.000 11.730 0 120 GLY A O   1 ? 
ATOM   880  N  N   . TRP A 1 121 ? 6.750   -21.099 7.784   1.000 11.117 0 121 TRP A N   1 ? 
ATOM   881  C  CA  . TRP A 1 121 ? 7.955   -20.379 7.357   1.000 12.409 0 121 TRP A CA  1 ? 
ATOM   882  C  C   . TRP A 1 121 ? 8.141   -19.036 8.063   1.000 13.439 0 121 TRP A C   1 ? 
ATOM   883  O  O   . TRP A 1 121 ? 8.823   -18.126 7.584   1.000 14.588 0 121 TRP A O   1 ? 
ATOM   884  C  CB  . TRP A 1 121 ? 7.969   -20.221 5.839   1.000 12.393 0 121 TRP A CB  1 ? 
ATOM   885  C  CG  . TRP A 1 121 ? 8.118   -21.452 5.003   1.000 11.765 0 121 TRP A CG  1 ? 
ATOM   886  C  CD1 . TRP A 1 121 ? 9.287   -22.066 4.642   1.000 12.090 0 121 TRP A CD1 1 ? 
ATOM   887  C  CD2 . TRP A 1 121 ? 7.048   -22.190 4.393   1.000 10.970 0 121 TRP A CD2 1 ? 
ATOM   888  N  NE1 . TRP A 1 121 ? 9.011   -23.134 3.848   1.000 13.749 0 121 TRP A NE1 1 ? 
ATOM   889  C  CE2 . TRP A 1 121 ? 7.648   -23.238 3.671   1.000 10.717 0 121 TRP A CE2 1 ? 
ATOM   890  C  CE3 . TRP A 1 121 ? 5.651   -22.019 4.321   1.000 10.930 0 121 TRP A CE3 1 ? 
ATOM   891  C  CZ2 . TRP A 1 121 ? 6.885   -24.131 2.938   1.000 11.795 0 121 TRP A CZ2 1 ? 
ATOM   892  C  CZ3 . TRP A 1 121 ? 4.914   -22.946 3.659   1.000 11.364 0 121 TRP A CZ3 1 ? 
ATOM   893  C  CH2 . TRP A 1 121 ? 5.528   -23.972 2.955   1.000 11.796 0 121 TRP A CH2 1 ? 
ATOM   894  N  N   . GLY A 1 122 ? 7.551   -18.880 9.229   1.000 13.810 0 122 GLY A N   1 ? 
ATOM   895  C  CA  . GLY A 1 122 ? 7.653   -17.629 9.952   1.000 12.350 0 122 GLY A CA  1 ? 
ATOM   896  C  C   . GLY A 1 122 ? 8.972   -17.469 10.706  1.000 13.151 0 122 GLY A C   1 ? 
ATOM   897  O  O   . GLY A 1 122 ? 9.847   -18.320 10.690  1.000 11.939 0 122 GLY A O   1 ? 
ATOM   898  N  N   . ASN A 1 123 ? 9.044   -16.334 11.383  1.000 14.189 0 123 ASN A N   1 ? 
ATOM   899  C  CA  . ASN A 1 123 ? 10.208  -15.933 12.150  1.000 14.846 0 123 ASN A CA  1 ? 
ATOM   900  C  C   . ASN A 1 123 ? 10.572  -17.004 13.159  1.000 15.774 0 123 ASN A C   1 ? 
ATOM   901  O  O   . ASN A 1 123 ? 9.708   -17.621 13.759  1.000 14.837 0 123 ASN A O   1 ? 
ATOM   902  C  CB  . ASN A 1 123 ? 9.893   -14.620 12.847  1.000 16.710 0 123 ASN A CB  1 ? 
ATOM   903  C  CG  . ASN A 1 123 ? 11.073  -13.894 13.435  1.000 18.149 0 123 ASN A CG  1 ? 
ATOM   904  O  OD1 . ASN A 1 123 ? 12.226  -14.276 13.258  1.000 21.216 0 123 ASN A OD1 1 ? 
ATOM   905  N  ND2 . ASN A 1 123 ? 10.778  -12.880 14.232  1.000 23.369 0 123 ASN A ND2 1 ? 
ATOM   906  N  N   . THR A 1 124 ? 11.892  -17.204 13.310  1.000 14.946 0 124 THR A N   1 ? 
ATOM   907  C  CA  . THR A 1 124 ? 12.440  -18.240 14.173  1.000 16.109 0 124 THR A CA  1 ? 
ATOM   908  C  C   . THR A 1 124 ? 13.035  -17.621 15.453  1.000 21.274 0 124 THR A C   1 ? 
ATOM   909  O  O   . THR A 1 124 ? 13.544  -18.361 16.286  1.000 20.973 0 124 THR A O   1 ? 
ATOM   910  C  CB  . THR A 1 124 ? 13.497  -19.086 13.446  1.000 17.287 0 124 THR A CB  1 ? 
ATOM   911  O  OG1 . THR A 1 124 ? 14.589  -18.239 13.101  1.000 20.717 0 124 THR A OG1 1 ? 
ATOM   912  C  CG2 . THR A 1 124 ? 12.999  -19.756 12.176  1.000 18.656 0 124 THR A CG2 1 ? 
ATOM   913  N  N   . LYS A 1 125 ? 12.971  -16.297 15.632  1.000 22.016 0 125 LYS A N   1 ? 
ATOM   914  C  CA  . LYS A 1 125 ? 13.491  -15.671 16.858  1.000 27.762 0 125 LYS A CA  1 ? 
ATOM   915  C  C   . LYS A 1 125 ? 12.378  -15.050 17.706  1.000 27.731 0 125 LYS A C   1 ? 
ATOM   916  O  O   . LYS A 1 125 ? 11.425  -14.517 17.172  1.000 27.153 0 125 LYS A O   1 ? 
ATOM   917  C  CB  . LYS A 1 125 ? 14.481  -14.574 16.453  1.000 32.941 0 125 LYS A CB  1 ? 
ATOM   918  C  CG  . LYS A 1 125 ? 15.730  -15.068 15.727  1.000 38.285 0 125 LYS A CG  1 ? 
ATOM   919  C  CD  . LYS A 1 125 ? 16.962  -15.074 16.619  1.000 48.915 0 125 LYS A CD  1 ? 
ATOM   920  C  CE  . LYS A 1 125 ? 18.202  -14.663 15.887  1.000 53.690 0 125 LYS A CE  1 ? 
ATOM   921  N  NZ  . LYS A 1 125 ? 18.600  -15.659 14.890  1.000 55.998 0 125 LYS A NZ  1 ? 
ATOM   922  N  N   . SER A 1 126 ? 12.513  -15.080 19.040  1.000 34.667 0 126 SER A N   1 ? 
ATOM   923  C  CA  . SER A 1 126 ? 11.591  -14.386 19.940  1.000 35.604 0 126 SER A CA  1 ? 
ATOM   924  C  C   . SER A 1 126 ? 11.966  -12.917 20.090  1.000 39.945 0 126 SER A C   1 ? 
ATOM   925  O  O   . SER A 1 126 ? 11.152  -12.084 20.518  1.000 43.495 0 126 SER A O   1 ? 
ATOM   926  C  CB  . SER A 1 126 ? 11.561  -15.037 21.300  1.000 39.346 0 126 SER A CB  1 ? 
ATOM   927  O  OG  . SER A 1 126 ? 12.873  -15.159 21.829  1.000 37.896 0 126 SER A OG  1 ? 
ATOM   928  N  N   . SER A 1 127 ? 13.229  -12.634 19.771  1.000 38.247 0 127 SER A N   1 ? 
ATOM   929  C  CA  . SER A 1 127 ? 13.771  -11.289 19.809  1.000 43.518 0 127 SER A CA  1 ? 
ATOM   930  C  C   . SER A 1 127 ? 14.676  -11.149 18.589  1.000 43.676 0 127 SER A C   1 ? 
ATOM   931  O  O   . SER A 1 127 ? 15.604  -11.937 18.422  1.000 44.964 0 127 SER A O   1 ? 
ATOM   932  C  CB  . SER A 1 127 ? 14.515  -11.048 21.109  1.000 46.844 0 127 SER A CB  1 ? 
ATOM   933  O  OG  . SER A 1 127 ? 14.050  -9.864  21.747  1.000 52.809 0 127 SER A OG  1 ? 
ATOM   934  N  N   . GLY A 1 128 ? 14.354  -10.202 17.706  1.000 38.025 0 128 GLY A N   1 ? 
ATOM   935  C  CA  . GLY A 1 128 ? 15.065  -10.088 16.444  1.000 36.903 0 128 GLY A CA  1 ? 
ATOM   936  C  C   . GLY A 1 128 ? 14.324  -10.845 15.348  1.000 36.365 0 128 GLY A C   1 ? 
ATOM   937  O  O   . GLY A 1 128 ? 13.198  -11.298 15.562  1.000 32.748 0 128 GLY A O   1 ? 
ATOM   938  N  N   . THR A 1 129 ? 14.968  -10.953 14.184  1.000 32.561 0 129 THR A N   1 ? 
ATOM   939  C  CA  . THR A 1 129 ? 14.299  -11.362 12.962  1.000 31.974 0 129 THR A CA  1 ? 
ATOM   940  C  C   . THR A 1 129 ? 15.202  -12.304 12.181  1.000 30.835 0 129 THR A C   1 ? 
ATOM   941  O  O   . THR A 1 129 ? 16.282  -11.911 11.732  1.000 26.106 0 129 THR A O   1 ? 
ATOM   942  C  CB  . THR A 1 129 ? 13.941  -10.127 12.140  1.000 38.724 0 129 THR A CB  1 ? 
ATOM   943  O  OG1 . THR A 1 129 ? 13.088  -9.373  12.993  1.000 44.566 0 129 THR A OG1 1 ? 
ATOM   944  C  CG2 . THR A 1 129 ? 13.152  -10.470 10.891  1.000 40.917 0 129 THR A CG2 1 ? 
ATOM   945  N  N   . SER A 1 130 ? 14.722  -13.543 11.984  1.000 22.564 0 130 SER A N   1 ? 
ATOM   946  C  CA  . SER A 1 130 ? 15.418  -14.482 11.134  1.000 25.203 0 130 SER A CA  1 ? 
ATOM   947  C  C   . SER A 1 130 ? 14.400  -15.398 10.477  1.000 23.087 0 130 SER A C   1 ? 
ATOM   948  O  O   . SER A 1 130 ? 13.750  -16.156 11.178  1.000 23.731 0 130 SER A O   1 ? 
ATOM   949  C  CB  . SER A 1 130 ? 16.404  -15.305 11.878  1.000 27.258 0 130 SER A CB  1 ? 
ATOM   950  O  OG  . SER A 1 130 ? 17.124  -16.071 10.923  1.000 29.140 0 130 SER A OG  1 ? 
ATOM   951  N  N   . TYR A 1 131 ? 14.235  -15.253 9.172   1.000 20.251 0 131 TYR A N   1 ? 
ATOM   952  C  CA  . TYR A 1 131 ? 13.244  -16.049 8.470   1.000 20.049 0 131 TYR A CA  1 ? 
ATOM   953  C  C   . TYR A 1 131 ? 13.933  -17.232 7.839   1.000 22.457 0 131 TYR A C   1 ? 
ATOM   954  O  O   . TYR A 1 131 ? 14.975  -17.085 7.188   1.000 25.359 0 131 TYR A O   1 ? 
ATOM   955  C  CB  . TYR A 1 131 ? 12.474  -15.226 7.438   1.000 21.908 0 131 TYR A CB  1 ? 
ATOM   956  C  CG  . TYR A 1 131 ? 11.469  -14.313 8.122   1.000 24.152 0 131 TYR A CG  1 ? 
ATOM   957  C  CD1 . TYR A 1 131 ? 11.845  -13.084 8.671   1.000 25.029 0 131 TYR A CD1 1 ? 
ATOM   958  C  CD2 . TYR A 1 131 ? 10.159  -14.732 8.305   1.000 26.614 0 131 TYR A CD2 1 ? 
ATOM   959  C  CE1 . TYR A 1 131 ? 10.918  -12.267 9.297   1.000 28.444 0 131 TYR A CE1 1 ? 
ATOM   960  C  CE2 . TYR A 1 131 ? 9.231   -13.922 8.935   1.000 26.795 0 131 TYR A CE2 1 ? 
ATOM   961  C  CZ  . TYR A 1 131 ? 9.612   -12.700 9.446   1.000 30.928 0 131 TYR A CZ  1 ? 
ATOM   962  O  OH  . TYR A 1 131 ? 8.671   -11.934 10.061  1.000 35.292 0 131 TYR A OH  1 ? 
ATOM   963  N  N   . PRO A 1 132 ? 13.351  -18.440 7.954   1.000 18.353 0 132 PRO A N   1 ? 
ATOM   964  C  CA  . PRO A 1 132 ? 13.969  -19.621 7.366   1.000 16.933 0 132 PRO A CA  1 ? 
ATOM   965  C  C   . PRO A 1 132 ? 13.506  -19.766 5.926   1.000 18.052 0 132 PRO A C   1 ? 
ATOM   966  O  O   . PRO A 1 132 ? 12.477  -19.257 5.511   1.000 23.636 0 132 PRO A O   1 ? 
ATOM   967  C  CB  . PRO A 1 132 ? 13.430  -20.683 8.289   1.000 17.494 0 132 PRO A CB  1 ? 
ATOM   968  C  CG  . PRO A 1 132 ? 11.962  -20.238 8.483   1.000 18.303 0 132 PRO A CG  1 ? 
ATOM   969  C  CD  . PRO A 1 132 ? 12.107  -18.751 8.695   1.000 17.273 0 132 PRO A CD  1 ? 
ATOM   970  N  N   . ASP A 1 133 ? 14.267  -20.492 5.154   1.000 22.100 0 133 ASP A N   1 ? 
ATOM   971  C  CA  . ASP A 1 133 ? 13.799  -20.767 3.823   1.000 21.342 0 133 ASP A CA  1 ? 
ATOM   972  C  C   . ASP A 1 133 ? 13.076  -22.112 3.783   1.000 19.694 0 133 ASP A C   1 ? 
ATOM   973  O  O   . ASP A 1 133 ? 12.281  -22.321 2.883   1.000 18.384 0 133 ASP A O   1 ? 
ATOM   974  C  CB  . ASP A 1 133 ? 14.924  -20.610 2.821   1.000 22.195 0 133 ASP A CB  1 ? 
ATOM   975  C  CG  . ASP A 1 133 ? 16.133  -21.499 3.054   1.000 28.766 0 133 ASP A CG  1 ? 
ATOM   976  O  OD1 . ASP A 1 133 ? 16.140  -22.239 4.077   1.000 32.992 0 133 ASP A OD1 1 ? 
ATOM   977  O  OD2 . ASP A 1 133 ? 17.069  -21.449 2.218   1.000 33.406 0 133 ASP A OD2 1 ? 
ATOM   978  N  N   . VAL A 1 134 ? 13.380  -23.032 4.716   1.000 16.812 0 134 VAL A N   1 ? 
ATOM   979  C  CA  . VAL A 1 134 ? 12.763  -24.341 4.728   1.000 16.723 0 134 VAL A CA  1 ? 
ATOM   980  C  C   . VAL A 1 134 ? 11.719  -24.416 5.846   1.000 13.667 0 134 VAL A C   1 ? 
ATOM   981  O  O   . VAL A 1 134 ? 11.740  -23.658 6.809   1.000 14.633 0 134 VAL A O   1 ? 
ATOM   982  C  CB  . VAL A 1 134 ? 13.740  -25.514 4.859   1.000 20.323 0 134 VAL A CB  1 ? 
ATOM   983  C  CG1 . VAL A 1 134 ? 14.722  -25.577 3.692   1.000 22.607 0 134 VAL A CG1 1 ? 
ATOM   984  C  CG2 . VAL A 1 134 ? 14.461  -25.439 6.205   1.000 22.322 0 134 VAL A CG2 1 ? 
ATOM   985  N  N   . LEU A 1 135 ? 10.746  -25.313 5.626   1.000 13.876 0 135 LEU A N   1 ? 
ATOM   986  C  CA  . LEU A 1 135 ? 9.623   -25.446 6.536   1.000 12.584 0 135 LEU A CA  1 ? 
ATOM   987  C  C   . LEU A 1 135 ? 10.042  -25.943 7.916   1.000 13.484 0 135 LEU A C   1 ? 
ATOM   988  O  O   . LEU A 1 135 ? 10.839  -26.880 8.027   1.000 14.248 0 135 LEU A O   1 ? 
ATOM   989  C  CB  . LEU A 1 135 ? 8.584   -26.369 5.905   1.000 13.891 0 135 LEU A CB  1 ? 
ATOM   990  C  CG  . LEU A 1 135 ? 7.231   -26.480 6.607   1.000 12.953 0 135 LEU A CG  1 ? 
ATOM   991  C  CD1 . LEU A 1 135 ? 6.547   -25.145 6.536   1.000 13.410 0 135 LEU A CD1 1 ? 
ATOM   992  C  CD2 . LEU A 1 135 ? 6.399   -27.574 5.974   1.000 13.917 0 135 LEU A CD2 1 ? 
ATOM   993  N  N   . LYS A 1 136 ? 9.611   -25.221 8.963   1.000 11.871 0 136 LYS A N   1 ? 
ATOM   994  C  CA  . LYS A 1 136 ? 9.829   -25.601 10.342  1.000 12.540 0 136 LYS A CA  1 ? 
ATOM   995  C  C   . LYS A 1 136 ? 8.556   -26.135 10.971  1.000 11.677 0 136 LYS A C   1 ? 
ATOM   996  O  O   . LYS A 1 136 ? 7.433   -25.792 10.612  1.000 10.991 0 136 LYS A O   1 ? 
ATOM   997  C  CB  . LYS A 1 136 ? 10.326  -24.380 11.113  1.000 11.940 0 136 LYS A CB  1 ? 
ATOM   998  C  CG  . LYS A 1 136 ? 11.627  -23.720 10.665  1.000 14.985 0 136 LYS A CG  1 ? 
ATOM   999  C  CD  . LYS A 1 136 ? 12.827  -24.649 10.771  1.000 18.440 0 136 LYS A CD  1 ? 
ATOM   1000 C  CE  . LYS A 1 136 ? 14.044  -23.969 10.202  1.000 23.436 0 136 LYS A CE  1 ? 
ATOM   1001 N  NZ  . LYS A 1 136 ? 15.188  -24.775 10.666  1.000 27.178 0 136 LYS A NZ  1 ? 
ATOM   1002 N  N   . CYS A 1 137 ? 8.750   -26.971 11.993  1.000 11.152 0 137 CYS A N   1 ? 
ATOM   1003 C  CA  . CYS A 1 137 ? 7.698   -27.704 12.668  1.000 13.088 0 137 CYS A CA  1 ? 
ATOM   1004 C  C   . CYS A 1 137 ? 7.891   -27.549 14.170  1.000 13.645 0 137 CYS A C   1 ? 
ATOM   1005 O  O   . CYS A 1 137 ? 8.981   -27.295 14.646  1.000 15.019 0 137 CYS A O   1 ? 
ATOM   1006 C  CB  . CYS A 1 137 ? 7.802   -29.177 12.345  1.000 12.947 0 137 CYS A CB  1 ? 
ATOM   1007 S  SG  . CYS A 1 137 ? 7.088   -29.699 10.782  1.000 14.184 0 137 CYS A SG  1 ? 
ATOM   1008 N  N   . LEU A 1 138 ? 6.776   -27.659 14.899  1.000 12.784 0 138 LEU A N   1 ? 
ATOM   1009 C  CA  . LEU A 1 138 ? 6.824   -27.603 16.333  1.000 13.122 0 138 LEU A CA  1 ? 
ATOM   1010 C  C   . LEU A 1 138 ? 5.742   -28.539 16.821  1.000 13.263 0 138 LEU A C   1 ? 
ATOM   1011 O  O   . LEU A 1 138 ? 4.603   -28.461 16.376  1.000 13.219 0 138 LEU A O   1 ? 
ATOM   1012 C  CB  . LEU A 1 138 ? 6.551   -26.170 16.764  1.000 16.296 0 138 LEU A CB  1 ? 
ATOM   1013 C  CG  . LEU A 1 138 ? 6.385   -25.940 18.262  1.000 18.961 0 138 LEU A CG  1 ? 
ATOM   1014 C  CD1 . LEU A 1 138 ? 7.764   -26.108 18.885  1.000 22.588 0 138 LEU A CD1 1 ? 
ATOM   1015 C  CD2 . LEU A 1 138 ? 5.777   -24.568 18.501  1.000 20.855 0 138 LEU A CD2 1 ? 
ATOM   1016 N  N   . LYS A 1 139 ? 6.058   -29.368 17.841  1.000 11.945 0 139 LYS A N   1 ? 
ATOM   1017 C  CA  . LYS A 1 139 ? 5.007   -30.042 18.561  1.000 15.067 0 139 LYS A CA  1 ? 
ATOM   1018 C  C   . LYS A 1 139 ? 4.663   -29.247 19.810  1.000 14.042 0 139 LYS A C   1 ? 
ATOM   1019 O  O   . LYS A 1 139 ? 5.529   -28.799 20.569  1.000 15.690 0 139 LYS A O   1 ? 
ATOM   1020 C  CB  . LYS A 1 139 ? 5.503   -31.457 18.869  1.000 18.061 0 139 LYS A CB  1 ? 
ATOM   1021 C  CG  . LYS A 1 139 ? 5.614   -32.305 17.621  1.000 20.156 0 139 LYS A CG  1 ? 
ATOM   1022 C  CD  . LYS A 1 139 ? 6.128   -33.669 18.024  1.000 23.598 0 139 LYS A CD  1 ? 
ATOM   1023 C  CE  . LYS A 1 139 ? 6.026   -34.623 16.892  1.000 29.012 0 139 LYS A CE  1 ? 
ATOM   1024 N  NZ  . LYS A 1 139 ? 6.267   -35.969 17.398  1.000 29.603 0 139 LYS A NZ  1 ? 
ATOM   1025 N  N   . ALA A 1 140 ? 3.366   -29.080 20.041  1.000 14.664 0 140 ALA A N   1 ? 
ATOM   1026 C  CA  . ALA A 1 140 ? 2.939   -28.295 21.174  1.000 15.936 0 140 ALA A CA  1 ? 
ATOM   1027 C  C   . ALA A 1 140 ? 1.616   -28.832 21.666  1.000 14.930 0 140 ALA A C   1 ? 
ATOM   1028 O  O   . ALA A 1 140 ? 0.770   -29.248 20.878  1.000 17.163 0 140 ALA A O   1 ? 
ATOM   1029 C  CB  . ALA A 1 140 ? 2.811   -26.831 20.812  1.000 17.943 0 140 ALA A CB  1 ? 
ATOM   1030 N  N   . PRO A 1 141 ? 1.379   -28.830 22.983  1.000 15.625 0 141 PRO A N   1 ? 
ATOM   1031 C  CA  . PRO A 1 141 ? 0.091   -29.272 23.497  1.000 16.255 0 141 PRO A CA  1 ? 
ATOM   1032 C  C   . PRO A 1 141 ? -0.966  -28.188 23.515  1.000 16.591 0 141 PRO A C   1 ? 
ATOM   1033 O  O   . PRO A 1 141 ? -0.687  -27.012 23.710  1.000 16.553 0 141 PRO A O   1 ? 
ATOM   1034 C  CB  . PRO A 1 141 ? 0.452   -29.689 24.927  1.000 17.970 0 141 PRO A CB  1 ? 
ATOM   1035 C  CG  . PRO A 1 141 ? 1.506   -28.764 25.312  1.000 17.874 0 141 PRO A CG  1 ? 
ATOM   1036 C  CD  . PRO A 1 141 ? 2.328   -28.505 24.052  1.000 16.773 0 141 PRO A CD  1 ? 
ATOM   1037 N  N   . ILE A 1 142 ? -2.208  -28.640 23.411  1.000 15.951 0 142 ILE A N   1 ? 
ATOM   1038 C  CA  . ILE A 1 142 ? -3.324  -27.757 23.676  1.000 15.506 0 142 ILE A CA  1 ? 
ATOM   1039 C  C   . ILE A 1 142 ? -3.370  -27.507 25.178  1.000 15.892 0 142 ILE A C   1 ? 
ATOM   1040 O  O   . ILE A 1 142 ? -3.283  -28.463 25.992  1.000 17.478 0 142 ILE A O   1 ? 
ATOM   1041 C  CB  . ILE A 1 142 ? -4.612  -28.374 23.142  1.000 15.596 0 142 ILE A CB  1 ? 
ATOM   1042 C  CG1 . ILE A 1 142 ? -4.574  -28.550 21.627  1.000 18.047 0 142 ILE A CG1 1 ? 
ATOM   1043 C  CG2 . ILE A 1 142 ? -5.828  -27.552 23.561  1.000 17.150 0 142 ILE A CG2 1 ? 
ATOM   1044 C  CD1 . ILE A 1 142 ? -5.783  -29.277 21.073  1.000 20.633 0 142 ILE A CD1 1 ? 
ATOM   1045 N  N   . LEU A 1 143 ? -3.606  -26.249 25.536  1.000 17.022 0 143 LEU A N   1 ? 
ATOM   1046 C  CA  . LEU A 1 143 ? -3.653  -25.817 26.918  1.000 17.735 0 143 LEU A CA  1 ? 
ATOM   1047 C  C   . LEU A 1 143 ? -5.099  -25.825 27.381  1.000 19.420 0 143 LEU A C   1 ? 
ATOM   1048 O  O   . LEU A 1 143 ? -6.015  -25.762 26.583  1.000 19.923 0 143 LEU A O   1 ? 
ATOM   1049 C  CB  . LEU A 1 143 ? -2.949  -24.474 27.096  1.000 19.507 0 143 LEU A CB  1 ? 
ATOM   1050 C  CG  . LEU A 1 143 ? -1.463  -24.458 26.739  1.000 22.779 0 143 LEU A CG  1 ? 
ATOM   1051 C  CD1 . LEU A 1 143 ? -0.880  -23.079 26.808  1.000 23.434 0 143 LEU A CD1 1 ? 
ATOM   1052 C  CD2 . LEU A 1 143 ? -0.672  -25.374 27.629  1.000 28.073 0 143 LEU A CD2 1 ? 
ATOM   1053 N  N   . SER A 1 144 ? -5.309  -25.937 28.707  1.000 19.312 0 144 SER A N   1 ? 
ATOM   1054 C  CA  . SER A 1 144 ? -6.661  -25.894 29.217  1.000 23.710 0 144 SER A CA  1 ? 
ATOM   1055 C  C   . SER A 1 144 ? -7.202  -24.502 28.955  1.000 20.663 0 144 SER A C   1 ? 
ATOM   1056 O  O   . SER A 1 144 ? -6.452  -23.530 28.916  1.000 23.132 0 144 SER A O   1 ? 
ATOM   1057 C  CB  . SER A 1 144 ? -6.693  -26.208 30.707  1.000 25.379 0 144 SER A CB  1 ? 
ATOM   1058 O  OG  . SER A 1 144 ? -5.942  -25.223 31.399  1.000 27.219 0 144 SER A OG  1 ? 
ATOM   1059 N  N   . ASP A 1 145 ? -8.511  -24.418 28.822  1.000 22.993 0 145 ASP A N   1 ? 
ATOM   1060 C  CA  . ASP A 1 145 ? -9.166  -23.140 28.620  1.000 28.545 0 145 ASP A CA  1 ? 
ATOM   1061 C  C   . ASP A 1 145 ? -8.890  -22.213 29.794  1.000 27.021 0 145 ASP A C   1 ? 
ATOM   1062 O  O   . ASP A 1 145 ? -8.711  -21.024 29.599  1.000 26.702 0 145 ASP A O   1 ? 
ATOM   1063 C  CB  . ASP A 1 145 ? -10.644 -23.326 28.345  1.000 33.659 0 145 ASP A CB  1 ? 
ATOM   1064 C  CG  . ASP A 1 145 ? -10.920 -23.899 26.964  1.000 40.300 0 145 ASP A CG  1 ? 
ATOM   1065 O  OD1 . ASP A 1 145 ? -10.098 -23.652 26.039  1.000 39.744 0 145 ASP A OD1 1 ? 
ATOM   1066 O  OD2 . ASP A 1 145 ? -11.922 -24.618 26.840  1.000 46.385 0 145 ASP A OD2 1 ? 
ATOM   1067 N  N   . SER A 1 146 ? -8.770  -22.746 31.005  1.000 26.476 0 146 SER A N   1 ? 
ATOM   1068 C  CA  . SER A 1 146 ? -8.568  -21.850 32.124  1.000 28.777 0 146 SER A CA  1 ? 
ATOM   1069 C  C   . SER A 1 146 ? -7.165  -21.235 32.085  1.000 25.512 0 146 SER A C   1 ? 
ATOM   1070 O  O   . SER A 1 146 ? -7.007  -20.056 32.353  1.000 24.766 0 146 SER A O   1 ? 
ATOM   1071 C  CB  . SER A 1 146 ? -8.850  -22.559 33.431  1.000 32.927 0 146 SER A CB  1 ? 
ATOM   1072 O  OG  . SER A 1 146 ? -7.766  -23.422 33.703  1.000 38.625 0 146 SER A OG  1 ? 
ATOM   1073 N  N   . SER A 1 147 ? -6.139  -21.995 31.672  1.000 24.672 0 147 SER A N   1 ? 
ATOM   1074 C  CA  . SER A 1 147 ? -4.807  -21.442 31.540  1.000 24.717 0 147 SER A CA  1 ? 
ATOM   1075 C  C   . SER A 1 147 ? -4.739  -20.443 30.372  1.000 23.472 0 147 SER A C   1 ? 
ATOM   1076 O  O   . SER A 1 147 ? -3.994  -19.456 30.422  1.000 21.918 0 147 SER A O   1 ? 
ATOM   1077 C  CB  . SER A 1 147 ? -3.765  -22.532 31.439  1.000 31.144 0 147 SER A CB  1 ? 
ATOM   1078 O  OG  . SER A 1 147 ? -4.134  -23.483 30.454  1.000 41.750 0 147 SER A OG  1 ? 
ATOM   1079 N  N   . CYS A 1 148 ? -5.486  -20.731 29.306  1.000 19.417 0 148 CYS A N   1 ? 
ATOM   1080 C  CA  . CYS A 1 148 ? -5.610  -19.827 28.161  1.000 16.882 0 148 CYS A CA  1 ? 
ATOM   1081 C  C   . CYS A 1 148 ? -6.199  -18.471 28.580  1.000 19.719 0 148 CYS A C   1 ? 
ATOM   1082 O  O   . CYS A 1 148 ? -5.669  -17.421 28.211  1.000 18.407 0 148 CYS A O   1 ? 
ATOM   1083 C  CB  . CYS A 1 148 ? -6.427  -20.509 27.047  1.000 16.990 0 148 CYS A CB  1 ? 
ATOM   1084 S  SG  . CYS A 1 148 ? -6.283  -19.695 25.431  1.000 17.315 0 148 CYS A SG  1 ? 
ATOM   1085 N  N   . LYS A 1 149 ? -7.371  -18.491 29.238  1.000 22.145 0 149 LYS A N   1 ? 
ATOM   1086 C  CA  . LYS A 1 149 ? -8.050  -17.281 29.679  1.000 24.627 0 149 LYS A CA  1 ? 
ATOM   1087 C  C   . LYS A 1 149 ? -7.213  -16.521 30.699  1.000 25.454 0 149 LYS A C   1 ? 
ATOM   1088 O  O   . LYS A 1 149 ? -7.264  -15.297 30.710  1.000 26.896 0 149 LYS A O   1 ? 
ATOM   1089 C  CB  . LYS A 1 149 ? -9.435  -17.665 30.219  1.000 26.872 0 149 LYS A CB  1 ? 
ATOM   1090 C  CG  . LYS A 1 149 ? -10.394 -18.056 29.109  1.000 31.146 0 149 LYS A CG  1 ? 
ATOM   1091 C  CD  . LYS A 1 149 ? -11.698 -18.714 29.542  1.000 37.658 0 149 LYS A CD  1 ? 
ATOM   1092 C  CE  . LYS A 1 149 ? -12.738 -18.647 28.462  1.000 44.364 0 149 LYS A CE  1 ? 
ATOM   1093 N  NZ  . LYS A 1 149 ? -13.792 -19.661 28.602  1.000 48.046 0 149 LYS A NZ  1 ? 
ATOM   1094 N  N   . SER A 1 150 ? -6.445  -17.245 31.531  1.000 25.898 0 150 SER A N   1 ? 
ATOM   1095 C  CA  . SER A 1 150 ? -5.559  -16.620 32.502  1.000 27.397 0 150 SER A CA  1 ? 
ATOM   1096 C  C   . SER A 1 150 ? -4.447  -15.853 31.811  1.000 28.905 0 150 SER A C   1 ? 
ATOM   1097 O  O   . SER A 1 150 ? -4.036  -14.798 32.283  1.000 26.692 0 150 SER A O   1 ? 
ATOM   1098 C  CB  . SER A 1 150 ? -4.950  -17.604 33.459  1.000 32.397 0 150 SER A CB  1 ? 
ATOM   1099 O  OG  . SER A 1 150 ? -5.861  -17.887 34.505  1.000 40.260 0 150 SER A OG  1 ? 
ATOM   1100 N  N   . ALA A 1 151 ? -3.973  -16.386 30.674  1.000 24.578 0 151 ALA A N   1 ? 
ATOM   1101 C  CA  . ALA A 1 151 ? -2.852  -15.780 29.985  1.000 20.910 0 151 ALA A CA  1 ? 
ATOM   1102 C  C   . ALA A 1 151 ? -3.248  -14.498 29.254  1.000 19.610 0 151 ALA A C   1 ? 
ATOM   1103 O  O   . ALA A 1 151 ? -2.408  -13.607 29.075  1.000 21.913 0 151 ALA A O   1 ? 
ATOM   1104 C  CB  . ALA A 1 151 ? -2.254  -16.765 28.998  1.000 21.695 0 151 ALA A CB  1 ? 
ATOM   1105 N  N   . TYR A 1 152 ? -4.489  -14.482 28.741  1.000 17.310 0 152 TYR A N   1 ? 
ATOM   1106 C  CA  . TYR A 1 152 ? -5.025  -13.393 27.931  1.000 17.818 0 152 TYR A CA  1 ? 
ATOM   1107 C  C   . TYR A 1 152 ? -6.387  -12.970 28.439  1.000 19.721 0 152 TYR A C   1 ? 
ATOM   1108 O  O   . TYR A 1 152 ? -7.428  -13.214 27.820  1.000 18.491 0 152 TYR A O   1 ? 
ATOM   1109 C  CB  . TYR A 1 152 ? -5.180  -13.876 26.511  1.000 17.459 0 152 TYR A CB  1 ? 
ATOM   1110 C  CG  . TYR A 1 152 ? -3.852  -14.158 25.879  1.000 17.243 0 152 TYR A CG  1 ? 
ATOM   1111 C  CD1 . TYR A 1 152 ? -3.005  -13.134 25.471  1.000 17.639 0 152 TYR A CD1 1 ? 
ATOM   1112 C  CD2 . TYR A 1 152 ? -3.476  -15.457 25.609  1.000 17.649 0 152 TYR A CD2 1 ? 
ATOM   1113 C  CE1 . TYR A 1 152 ? -1.808  -13.407 24.821  1.000 18.444 0 152 TYR A CE1 1 ? 
ATOM   1114 C  CE2 . TYR A 1 152 ? -2.293  -15.736 24.952  1.000 16.791 0 152 TYR A CE2 1 ? 
ATOM   1115 C  CZ  . TYR A 1 152 ? -1.470  -14.714 24.528  1.000 17.997 0 152 TYR A CZ  1 ? 
ATOM   1116 O  OH  . TYR A 1 152 ? -0.294  -14.932 23.879  1.000 17.234 0 152 TYR A OH  1 ? 
ATOM   1117 N  N   . PRO A 1 153 ? -6.427  -12.361 29.645  1.000 21.372 0 153 PRO A N   1 ? 
ATOM   1118 C  CA  . PRO A 1 153 ? -7.699  -12.071 30.263  1.000 21.864 0 153 PRO A CA  1 ? 
ATOM   1119 C  C   . PRO A 1 153 ? -8.533  -11.150 29.395  1.000 20.058 0 153 PRO A C   1 ? 
ATOM   1120 O  O   . PRO A 1 153 ? -8.056  -10.167 28.846  1.000 24.098 0 153 PRO A O   1 ? 
ATOM   1121 C  CB  . PRO A 1 153 ? -7.396  -11.480 31.650  1.000 25.185 0 153 PRO A CB  1 ? 
ATOM   1122 C  CG  . PRO A 1 153 ? -5.906  -11.345 31.710  1.000 23.222 0 153 PRO A CG  1 ? 
ATOM   1123 C  CD  . PRO A 1 153 ? -5.278  -12.044 30.490  1.000 21.263 0 153 PRO A CD  1 ? 
ATOM   1124 N  N   . GLY A 1 154 ? -9.787  -11.546 29.241  1.000 21.810 0 154 GLY A N   1 ? 
ATOM   1125 C  CA  . GLY A 1 154 ? -10.734 -10.750 28.492  1.000 23.941 0 154 GLY A CA  1 ? 
ATOM   1126 C  C   . GLY A 1 154 ? -10.590 -10.856 26.974  1.000 24.168 0 154 GLY A C   1 ? 
ATOM   1127 O  O   . GLY A 1 154 ? -11.255 -10.088 26.282  1.000 27.920 0 154 GLY A O   1 ? 
ATOM   1128 N  N   . GLN A 1 155 ? -9.738  -11.753 26.449  1.000 21.502 0 155 GLN A N   1 ? 
ATOM   1129 C  CA  . GLN A 1 155 ? -9.449  -11.708 25.018  1.000 20.522 0 155 GLN A CA  1 ? 
ATOM   1130 C  C   . GLN A 1 155 ? -9.737  -13.041 24.326  1.000 20.113 0 155 GLN A C   1 ? 
ATOM   1131 O  O   . GLN A 1 155 ? -9.693  -13.116 23.100  1.000 21.427 0 155 GLN A O   1 ? 
ATOM   1132 C  CB  . GLN A 1 155 ? -7.998  -11.307 24.798  1.000 20.410 0 155 GLN A CB  1 ? 
ATOM   1133 C  CG  . GLN A 1 155 ? -7.650  -9.937  25.388  1.000 24.719 0 155 GLN A CG  1 ? 
ATOM   1134 C  CD  . GLN A 1 155 ? -6.171  -9.764  25.604  1.000 29.255 0 155 GLN A CD  1 ? 
ATOM   1135 O  OE1 . GLN A 1 155 ? -5.402  -9.701  24.651  1.000 29.407 0 155 GLN A OE1 1 ? 
ATOM   1136 N  NE2 . GLN A 1 155 ? -5.762  -9.652  26.855  1.000 33.092 0 155 GLN A NE2 1 ? 
ATOM   1137 N  N   . ILE A 1 156 ? -10.039 -14.089 25.092  1.000 19.876 0 156 ILE A N   1 ? 
ATOM   1138 C  CA  . ILE A 1 156 ? -10.189 -15.425 24.523  1.000 18.669 0 156 ILE A CA  1 ? 
ATOM   1139 C  C   . ILE A 1 156 ? -11.676 -15.693 24.361  1.000 18.706 0 156 ILE A C   1 ? 
ATOM   1140 O  O   . ILE A 1 156 ? -12.442 -15.654 25.327  1.000 20.543 0 156 ILE A O   1 ? 
ATOM   1141 C  CB  . ILE A 1 156 ? -9.493  -16.501 25.388  1.000 17.822 0 156 ILE A CB  1 ? 
ATOM   1142 C  CG1 . ILE A 1 156 ? -8.020  -16.187 25.570  1.000 18.547 0 156 ILE A CG1 1 ? 
ATOM   1143 C  CG2 . ILE A 1 156 ? -9.721  -17.915 24.846  1.000 21.365 0 156 ILE A CG2 1 ? 
ATOM   1144 C  CD1 . ILE A 1 156 ? -7.202  -16.161 24.296  1.000 18.465 0 156 ILE A CD1 1 ? 
ATOM   1145 N  N   . THR A 1 157 ? -12.102 -15.948 23.125  1.000 15.883 0 157 THR A N   1 ? 
ATOM   1146 C  CA  . THR A 1 157 ? -13.478 -16.343 22.855  1.000 15.772 0 157 THR A CA  1 ? 
ATOM   1147 C  C   . THR A 1 157 ? -13.553 -17.868 22.742  1.000 16.536 0 157 THR A C   1 ? 
ATOM   1148 O  O   . THR A 1 157 ? -12.568 -18.592 22.649  1.000 16.689 0 157 THR A O   1 ? 
ATOM   1149 C  CB  . THR A 1 157 ? -13.998 -15.649 21.594  1.000 17.175 0 157 THR A CB  1 ? 
ATOM   1150 O  OG1 . THR A 1 157 ? -13.350 -16.330 20.531  1.000 16.048 0 157 THR A OG1 1 ? 
ATOM   1151 C  CG2 . THR A 1 157 ? -13.686 -14.162 21.508  1.000 20.037 0 157 THR A CG2 1 ? 
ATOM   1152 N  N   . SER A 1 158 ? -14.774 -18.380 22.597  1.000 16.687 0 158 SER A N   1 ? 
ATOM   1153 C  CA  . SER A 1 158 ? -15.004 -19.794 22.441  1.000 17.663 0 158 SER A CA  1 ? 
ATOM   1154 C  C   . SER A 1 158 ? -14.507 -20.304 21.095  1.000 17.226 0 158 SER A C   1 ? 
ATOM   1155 O  O   . SER A 1 158 ? -14.519 -21.515 20.870  1.000 18.792 0 158 SER A O   1 ? 
ATOM   1156 C  CB  . SER A 1 158 ? -16.489 -20.083 22.616  1.000 22.848 0 158 SER A CB  1 ? 
ATOM   1157 O  OG  . SER A 1 158 ? -17.235 -19.326 21.687  1.000 27.488 0 158 SER A OG  1 ? 
ATOM   1158 N  N   . ASN A 1 159 ? -14.111 -19.374 20.210  1.000 14.164 0 159 ASN A N   1 ? 
ATOM   1159 C  CA  . ASN A 1 159 ? -13.652 -19.774 18.894  1.000 12.807 0 159 ASN A CA  1 ? 
ATOM   1160 C  C   . ASN A 1 159 ? -12.119 -19.769 18.838  1.000 14.422 0 159 ASN A C   1 ? 
ATOM   1161 O  O   . ASN A 1 159 ? -11.546 -19.823 17.760  1.000 13.192 0 159 ASN A O   1 ? 
ATOM   1162 C  CB  . ASN A 1 159 ? -14.111 -18.854 17.792  1.000 14.575 0 159 ASN A CB  1 ? 
ATOM   1163 C  CG  . ASN A 1 159 ? -15.613 -18.849 17.780  1.000 15.996 0 159 ASN A CG  1 ? 
ATOM   1164 O  OD1 . ASN A 1 159 ? -16.207 -19.929 17.757  1.000 18.040 0 159 ASN A OD1 1 ? 
ATOM   1165 N  ND2 . ASN A 1 159 ? -16.207 -17.675 17.893  1.000 17.634 0 159 ASN A ND2 1 ? 
ATOM   1166 N  N   . MET A 1 160 ? -11.494 -19.751 20.003  1.000 13.347 0 160 MET A N   1 ? 
ATOM   1167 C  CA  . MET A 1 160 ? -10.037 -19.716 20.093  1.000 13.381 0 160 MET A CA  1 ? 
ATOM   1168 C  C   . MET A 1 160 ? -9.561  -20.797 21.058  1.000 14.894 0 160 MET A C   1 ? 
ATOM   1169 O  O   . MET A 1 160 ? -10.279 -21.168 21.973  1.000 15.566 0 160 MET A O   1 ? 
ATOM   1170 C  CB  . MET A 1 160 ? -9.557  -18.383 20.644  1.000 13.817 0 160 MET A CB  1 ? 
ATOM   1171 C  CG  . MET A 1 160 ? -9.944  -17.220 19.745  1.000 13.263 0 160 MET A CG  1 ? 
ATOM   1172 S  SD  . MET A 1 160 ? -9.497  -15.697 20.570  1.000 14.773 0 160 MET A SD  1 ? 
ATOM   1173 C  CE  . MET A 1 160 ? -10.188 -14.473 19.437  1.000 17.614 0 160 MET A CE  1 ? 
ATOM   1174 N  N   . PHE A 1 161 ? -8.328  -21.278 20.880  1.000 13.088 0 161 PHE A N   1 ? 
ATOM   1175 C  CA  . PHE A 1 161 ? -7.701  -22.073 21.928  1.000 12.554 0 161 PHE A CA  1 ? 
ATOM   1176 C  C   . PHE A 1 161 ? -6.241  -21.697 22.003  1.000 13.364 0 161 PHE A C   1 ? 
ATOM   1177 O  O   . PHE A 1 161 ? -5.718  -21.172 21.026  1.000 14.483 0 161 PHE A O   1 ? 
ATOM   1178 C  CB  . PHE A 1 161 ? -7.871  -23.584 21.722  1.000 13.970 0 161 PHE A CB  1 ? 
ATOM   1179 C  CG  . PHE A 1 161 ? -7.197  -24.202 20.515  1.000 14.234 0 161 PHE A CG  1 ? 
ATOM   1180 C  CD1 . PHE A 1 161 ? -5.906  -24.699 20.560  1.000 14.612 0 161 PHE A CD1 1 ? 
ATOM   1181 C  CD2 . PHE A 1 161 ? -7.874  -24.251 19.297  1.000 15.524 0 161 PHE A CD2 1 ? 
ATOM   1182 C  CE1 . PHE A 1 161 ? -5.336  -25.273 19.431  1.000 16.706 0 161 PHE A CE1 1 ? 
ATOM   1183 C  CE2 . PHE A 1 161 ? -7.330  -24.895 18.192  1.000 15.392 0 161 PHE A CE2 1 ? 
ATOM   1184 C  CZ  . PHE A 1 161 ? -6.035  -25.371 18.258  1.000 14.516 0 161 PHE A CZ  1 ? 
ATOM   1185 N  N   . CYS A 1 162 ? -5.595  -22.049 23.113  1.000 12.225 0 162 CYS A N   1 ? 
ATOM   1186 C  CA  . CYS A 1 162 ? -4.179  -21.834 23.272  1.000 12.966 0 162 CYS A CA  1 ? 
ATOM   1187 C  C   . CYS A 1 162 ? -3.421  -23.155 23.122  1.000 13.117 0 162 CYS A C   1 ? 
ATOM   1188 O  O   . CYS A 1 162 ? -3.900  -24.205 23.543  1.000 14.398 0 162 CYS A O   1 ? 
ATOM   1189 C  CB  . CYS A 1 162 ? -3.843  -21.268 24.655  1.000 14.152 0 162 CYS A CB  1 ? 
ATOM   1190 S  SG  . CYS A 1 162 ? -4.391  -19.568 24.934  1.000 15.931 0 162 CYS A SG  1 ? 
ATOM   1191 N  N   . ALA A 1 163 ? -2.236  -23.088 22.519  1.000 12.875 0 163 ALA A N   1 ? 
ATOM   1192 C  CA  . ALA A 1 163 ? -1.359  -24.231 22.438  1.000 12.101 0 163 ALA A CA  1 ? 
ATOM   1193 C  C   . ALA A 1 163 ? 0.046   -23.720 22.603  1.000 13.047 0 163 ALA A C   1 ? 
ATOM   1194 O  O   . ALA A 1 163 ? 0.380   -22.636 22.120  1.000 14.820 0 163 ALA A O   1 ? 
ATOM   1195 C  CB  . ALA A 1 163 ? -1.544  -24.993 21.137  1.000 13.044 0 163 ALA A CB  1 ? 
ATOM   1196 N  N   . GLY A 1 164 ? 0.865   -24.479 23.333  1.000 15.131 0 164 GLY A N   1 ? 
ATOM   1197 C  CA  . GLY A 1 164 ? 2.228   -24.013 23.482  1.000 16.469 0 164 GLY A CA  1 ? 
ATOM   1198 C  C   . GLY A 1 164 ? 2.768   -24.346 24.865  1.000 17.548 0 164 GLY A C   1 ? 
ATOM   1199 O  O   . GLY A 1 164 ? 2.350   -25.320 25.488  1.000 19.193 0 164 GLY A O   1 ? 
ATOM   1200 N  N   . TYR A 1 165 ? 3.662   -23.480 25.317  1.000 20.781 0 165 TYR A N   1 ? 
ATOM   1201 C  CA  . TYR A 1 165 ? 4.447   -23.715 26.525  1.000 21.551 0 165 TYR A CA  1 ? 
ATOM   1202 C  C   . TYR A 1 165 ? 4.451   -22.438 27.329  1.000 21.934 0 165 TYR A C   1 ? 
ATOM   1203 O  O   . TYR A 1 165 ? 4.945   -21.431 26.850  1.000 22.995 0 165 TYR A O   1 ? 
ATOM   1204 C  CB  . TYR A 1 165 ? 5.866   -24.065 26.086  1.000 22.700 0 165 TYR A CB  1 ? 
ATOM   1205 C  CG  . TYR A 1 165 ? 5.922   -25.355 25.289  1.000 23.439 0 165 TYR A CG  1 ? 
ATOM   1206 C  CD1 . TYR A 1 165 ? 5.998   -26.584 25.919  1.000 23.309 0 165 TYR A CD1 1 ? 
ATOM   1207 C  CD2 . TYR A 1 165 ? 5.807   -25.350 23.908  1.000 23.864 0 165 TYR A CD2 1 ? 
ATOM   1208 C  CE1 . TYR A 1 165 ? 6.063   -27.761 25.206  1.000 23.853 0 165 TYR A CE1 1 ? 
ATOM   1209 C  CE2 . TYR A 1 165 ? 5.824   -26.528 23.191  1.000 22.969 0 165 TYR A CE2 1 ? 
ATOM   1210 C  CZ  . TYR A 1 165 ? 5.965   -27.738 23.837  1.000 22.261 0 165 TYR A CZ  1 ? 
ATOM   1211 O  OH  . TYR A 1 165 ? 6.007   -28.906 23.134  1.000 23.654 0 165 TYR A OH  1 ? 
ATOM   1212 N  N   . LEU A 1 166 ? 3.912   -22.493 28.541  1.000 23.582 0 166 LEU A N   1 ? 
ATOM   1213 C  CA  . LEU A 1 166 ? 3.826   -21.310 29.368  1.000 26.207 0 166 LEU A CA  1 ? 
ATOM   1214 C  C   . LEU A 1 166 ? 5.220   -20.861 29.800  1.000 27.260 0 166 LEU A C   1 ? 
ATOM   1215 O  O   . LEU A 1 166 ? 5.395   -19.695 30.116  1.000 28.290 0 166 LEU A O   1 ? 
ATOM   1216 C  CB  . LEU A 1 166 ? 2.944   -21.636 30.571  1.000 28.645 0 166 LEU A CB  1 ? 
ATOM   1217 C  CG  . LEU A 1 166 ? 1.461   -21.867 30.274  1.000 31.384 0 166 LEU A CG  1 ? 
ATOM   1218 C  CD1 . LEU A 1 166 ? 0.687   -22.134 31.546  1.000 34.526 0 166 LEU A CD1 1 ? 
ATOM   1219 C  CD2 . LEU A 1 166 ? 0.851   -20.681 29.568  1.000 31.409 0 166 LEU A CD2 1 ? 
ATOM   1220 N  N   . GLU A 1 167 ? 6.187   -21.787 29.840  1.000 26.748 0 167 GLU A N   1 ? 
ATOM   1221 C  CA  . GLU A 1 167 ? 7.560   -21.414 30.147  1.000 27.649 0 167 GLU A CA  1 ? 
ATOM   1222 C  C   . GLU A 1 167 ? 8.156   -20.561 29.030  1.000 29.711 0 167 GLU A C   1 ? 
ATOM   1223 O  O   . GLU A 1 167 ? 9.233   -20.007 29.204  1.000 30.483 0 167 GLU A O   1 ? 
ATOM   1224 C  CB  . GLU A 1 167 ? 8.422   -22.634 30.488  1.000 30.202 0 167 GLU A CB  1 ? 
ATOM   1225 C  CG  . GLU A 1 167 ? 8.495   -23.665 29.369  1.000 35.517 0 167 GLU A CG  1 ? 
ATOM   1226 C  CD  . GLU A 1 167 ? 7.412   -24.739 29.344  1.000 37.440 0 167 GLU A CD  1 ? 
ATOM   1227 O  OE1 . GLU A 1 167 ? 7.760   -25.847 28.880  1.000 41.862 0 167 GLU A OE1 1 ? 
ATOM   1228 O  OE2 . GLU A 1 167 ? 6.253   -24.509 29.751  1.000 31.953 0 167 GLU A OE2 1 ? 
ATOM   1229 N  N   . GLY A 1 168 ? 7.493   -20.506 27.861  1.000 28.150 0 168 GLY A N   1 ? 
ATOM   1230 C  CA  . GLY A 1 168 ? 8.031   -19.803 26.703  1.000 24.886 0 168 GLY A CA  1 ? 
ATOM   1231 C  C   . GLY A 1 168 ? 9.072   -20.643 25.953  1.000 26.471 0 168 GLY A C   1 ? 
ATOM   1232 O  O   . GLY A 1 168 ? 9.270   -21.811 26.244  1.000 30.171 0 168 GLY A O   1 ? 
ATOM   1233 N  N   . GLY A 1 169 ? 9.694   -20.021 24.947  1.000 23.071 0 169 GLY A N   1 ? 
ATOM   1234 C  CA  . GLY A 1 169 ? 10.800  -20.597 24.198  1.000 22.299 0 169 GLY A CA  1 ? 
ATOM   1235 C  C   . GLY A 1 169 ? 10.397  -21.282 22.896  1.000 19.967 0 169 GLY A C   1 ? 
ATOM   1236 O  O   . GLY A 1 169 ? 11.222  -21.418 21.993  1.000 21.972 0 169 GLY A O   1 ? 
ATOM   1237 N  N   . LYS A 1 170 ? 9.164   -21.764 22.834  1.000 17.762 0 170 LYS A N   1 ? 
ATOM   1238 C  CA  . LYS A 1 170 ? 8.674   -22.547 21.711  1.000 18.833 0 170 LYS A CA  1 ? 
ATOM   1239 C  C   . LYS A 1 170 ? 7.288   -22.023 21.349  1.000 16.846 0 170 LYS A C   1 ? 
ATOM   1240 O  O   . LYS A 1 170 ? 6.434   -21.951 22.212  1.000 18.533 0 170 LYS A O   1 ? 
ATOM   1241 C  CB  . LYS A 1 170 ? 8.570   -24.023 22.100  1.000 22.741 0 170 LYS A CB  1 ? 
ATOM   1242 C  CG  . LYS A 1 170 ? 9.923   -24.704 22.179  1.000 30.160 0 170 LYS A CG  1 ? 
ATOM   1243 C  CD  . LYS A 1 170 ? 9.856   -26.075 22.843  1.000 35.317 0 170 LYS A CD  1 ? 
ATOM   1244 C  CE  . LYS A 1 170 ? 9.681   -25.929 24.320  1.000 44.020 0 170 LYS A CE  1 ? 
ATOM   1245 N  NZ  . LYS A 1 170 ? 10.019  -27.158 25.052  1.000 51.361 0 170 LYS A NZ  1 ? 
ATOM   1246 N  N   . ASP A 1 171 ? 7.091   -21.619 20.078  1.000 14.579 0 171 ASP A N   1 ? 
ATOM   1247 C  CA  . ASP A 1 171 ? 5.857   -20.979 19.677  1.000 13.180 0 171 ASP A CA  1 ? 
ATOM   1248 C  C   . ASP A 1 171 ? 5.834   -20.760 18.175  1.000 14.740 0 171 ASP A C   1 ? 
ATOM   1249 O  O   . ASP A 1 171 ? 6.842   -20.865 17.485  1.000 14.935 0 171 ASP A O   1 ? 
ATOM   1250 C  CB  . ASP A 1 171 ? 5.724   -19.637 20.358  1.000 12.666 0 171 ASP A CB  1 ? 
ATOM   1251 C  CG  . ASP A 1 171 ? 4.355   -18.986 20.373  1.000 13.006 0 171 ASP A CG  1 ? 
ATOM   1252 O  OD1 . ASP A 1 171 ? 3.354   -19.640 19.923  1.000 13.145 0 171 ASP A OD1 1 ? 
ATOM   1253 O  OD2 . ASP A 1 171 ? 4.304   -17.850 20.892  1.000 15.700 0 171 ASP A OD2 1 ? 
ATOM   1254 N  N   . SER A 1 172 ? 4.632   -20.534 17.635  1.000 13.119 0 172 SER A N   1 ? 
ATOM   1255 C  CA  . SER A 1 172 ? 4.548   -20.007 16.290  1.000 13.277 0 172 SER A CA  1 ? 
ATOM   1256 C  C   . SER A 1 172 ? 4.834   -18.510 16.337  1.000 13.143 0 172 SER A C   1 ? 
ATOM   1257 O  O   . SER A 1 172 ? 4.989   -17.929 17.401  1.000 13.652 0 172 SER A O   1 ? 
ATOM   1258 C  CB  . SER A 1 172 ? 3.231   -20.403 15.644  1.000 13.012 0 172 SER A CB  1 ? 
ATOM   1259 O  OG  . SER A 1 172 ? 2.145   -19.850 16.348  1.000 13.620 0 172 SER A OG  1 ? 
ATOM   1260 N  N   . CYS A 1 173 ? 4.918   -17.860 15.172  1.000 12.699 0 173 CYS A N   1 ? 
ATOM   1261 C  CA  . CYS A 1 173 ? 5.349   -16.472 15.119  1.000 13.834 0 173 CYS A CA  1 ? 
ATOM   1262 C  C   . CYS A 1 173 ? 4.882   -15.825 13.817  1.000 13.923 0 173 CYS A C   1 ? 
ATOM   1263 O  O   . CYS A 1 173 ? 4.215   -16.476 13.012  1.000 13.587 0 173 CYS A O   1 ? 
ATOM   1264 C  CB  . CYS A 1 173 ? 6.853   -16.410 15.279  1.000 15.547 0 173 CYS A CB  1 ? 
ATOM   1265 S  SG  . CYS A 1 173 ? 7.474   -14.805 15.835  1.000 17.548 0 173 CYS A SG  1 ? 
ATOM   1266 N  N   . GLN A 1 174 ? 5.198   -14.537 13.651  1.000 15.849 0 174 GLN A N   1 ? 
ATOM   1267 C  CA  . GLN A 1 174 ? 4.827   -13.780 12.464  1.000 19.719 0 174 GLN A CA  1 ? 
ATOM   1268 C  C   . GLN A 1 174 ? 5.289   -14.529 11.215  1.000 16.427 0 174 GLN A C   1 ? 
ATOM   1269 O  O   . GLN A 1 174 ? 6.428   -14.961 11.172  1.000 17.008 0 174 GLN A O   1 ? 
ATOM   1270 C  CB  . GLN A 1 174 ? 5.515   -12.409 12.505  1.000 26.492 0 174 GLN A CB  1 ? 
ATOM   1271 C  CG  . GLN A 1 174 ? 4.765   -11.302 11.774  1.000 40.531 0 174 GLN A CG  1 ? 
ATOM   1272 C  CD  . GLN A 1 174 ? 5.060   -11.165 10.290  1.000 55.396 0 174 GLN A CD  1 ? 
ATOM   1273 O  OE1 . GLN A 1 174 ? 5.746   -11.987 9.658   1.000 58.716 0 174 GLN A OE1 1 ? 
ATOM   1274 N  NE2 . GLN A 1 174 ? 4.550   -10.073 9.725   1.000 54.290 0 174 GLN A NE2 1 ? 
ATOM   1275 N  N   . GLY A 1 175 ? 4.416   -14.661 10.218  1.000 12.196 0 175 GLY A N   1 ? 
ATOM   1276 C  CA  . GLY A 1 175 ? 4.755   -15.390 9.010   1.000 12.825 0 175 GLY A CA  1 ? 
ATOM   1277 C  C   . GLY A 1 175 ? 4.213   -16.814 9.035   1.000 12.036 0 175 GLY A C   1 ? 
ATOM   1278 O  O   . GLY A 1 175 ? 4.142   -17.470 7.997   1.000 12.668 0 175 GLY A O   1 ? 
ATOM   1279 N  N   . ASP A 1 176 ? 3.951   -17.334 10.241  1.000 10.616 0 176 ASP A N   1 ? 
ATOM   1280 C  CA  . ASP A 1 176 ? 3.309   -18.629 10.372  1.000 10.311 0 176 ASP A CA  1 ? 
ATOM   1281 C  C   . ASP A 1 176 ? 1.799   -18.502 10.289  1.000 9.967  0 176 ASP A C   1 ? 
ATOM   1282 O  O   . ASP A 1 176 ? 1.130   -19.526 10.139  1.000 10.608 0 176 ASP A O   1 ? 
ATOM   1283 C  CB  . ASP A 1 176 ? 3.634   -19.317 11.687  1.000 10.365 0 176 ASP A CB  1 ? 
ATOM   1284 C  CG  . ASP A 1 176 ? 5.104   -19.673 11.792  1.000 11.340 0 176 ASP A CG  1 ? 
ATOM   1285 O  OD1 . ASP A 1 176 ? 5.656   -20.180 10.793  1.000 11.087 0 176 ASP A OD1 1 ? 
ATOM   1286 O  OD2 . ASP A 1 176 ? 5.646   -19.434 12.875  1.000 13.764 0 176 ASP A OD2 1 ? 
ATOM   1287 N  N   . SER A 1 177 ? 1.276   -17.278 10.457  1.000 11.773 0 177 SER A N   1 ? 
ATOM   1288 C  CA  . SER A 1 177 ? -0.149  -16.975 10.396  1.000 11.715 0 177 SER A CA  1 ? 
ATOM   1289 C  C   . SER A 1 177 ? -0.853  -17.732 9.304   1.000 11.048 0 177 SER A C   1 ? 
ATOM   1290 O  O   . SER A 1 177 ? -0.370  -17.789 8.192   1.000 9.900  0 177 SER A O   1 ? 
ATOM   1291 C  CB  . SER A 1 177 ? -0.348  -15.483 10.170  1.000 15.228 0 177 SER A CB  1 ? 
ATOM   1292 O  OG  . SER A 1 177 ? -0.029  -14.807 11.370  1.000 19.052 0 177 SER A OG  1 ? 
ATOM   1293 N  N   . GLY A 1 178 ? -2.054  -18.246 9.599   1.000 9.998  0 178 GLY A N   1 ? 
ATOM   1294 C  CA  . GLY A 1 178 ? -2.790  -18.934 8.560   1.000 10.329 0 178 GLY A CA  1 ? 
ATOM   1295 C  C   . GLY A 1 178 ? -2.490  -20.408 8.492   1.000 10.966 0 178 GLY A C   1 ? 
ATOM   1296 O  O   . GLY A 1 178 ? -3.299  -21.143 7.921   1.000 11.532 0 178 GLY A O   1 ? 
ATOM   1297 N  N   . GLY A 1 179 ? -1.381  -20.834 9.075   1.000 10.565 0 179 GLY A N   1 ? 
ATOM   1298 C  CA  . GLY A 1 179 ? -0.897  -22.191 8.886   1.000 11.418 0 179 GLY A CA  1 ? 
ATOM   1299 C  C   . GLY A 1 179 ? -1.628  -23.176 9.814   1.000 11.959 0 179 GLY A C   1 ? 
ATOM   1300 O  O   . GLY A 1 179 ? -2.449  -22.838 10.678  1.000 11.921 0 179 GLY A O   1 ? 
ATOM   1301 N  N   . PRO A 1 180 ? -1.332  -24.462 9.608   1.000 11.488 0 180 PRO A N   1 ? 
ATOM   1302 C  CA  . PRO A 1 180 ? -2.011  -25.540 10.313  1.000 10.784 0 180 PRO A CA  1 ? 
ATOM   1303 C  C   . PRO A 1 180 ? -1.552  -25.834 11.728  1.000 11.730 0 180 PRO A C   1 ? 
ATOM   1304 O  O   . PRO A 1 180 ? -0.372  -25.824 12.003  1.000 12.768 0 180 PRO A O   1 ? 
ATOM   1305 C  CB  . PRO A 1 180 ? -1.699  -26.738 9.408   1.000 11.834 0 180 PRO A CB  1 ? 
ATOM   1306 C  CG  . PRO A 1 180 ? -0.377  -26.445 8.856   1.000 13.450 0 180 PRO A CG  1 ? 
ATOM   1307 C  CD  . PRO A 1 180 ? -0.333  -24.940 8.628   1.000 13.360 0 180 PRO A CD  1 ? 
ATOM   1308 N  N   . VAL A 1 181 ? -2.528  -26.270 12.505  1.000 11.314 0 181 VAL A N   1 ? 
ATOM   1309 C  CA  . VAL A 1 181 ? -2.305  -26.964 13.757  1.000 10.492 0 181 VAL A CA  1 ? 
ATOM   1310 C  C   . VAL A 1 181 ? -3.058  -28.292 13.615  1.000 11.763 0 181 VAL A C   1 ? 
ATOM   1311 O  O   . VAL A 1 181 ? -4.275  -28.284 13.547  1.000 11.884 0 181 VAL A O   1 ? 
ATOM   1312 C  CB  . VAL A 1 181 ? -2.856  -26.132 14.936  1.000 12.011 0 181 VAL A CB  1 ? 
ATOM   1313 C  CG1 . VAL A 1 181 ? -2.565  -26.872 16.235  1.000 13.769 0 181 VAL A CG1 1 ? 
ATOM   1314 C  CG2 . VAL A 1 181 ? -2.332  -24.691 14.984  1.000 13.650 0 181 VAL A CG2 1 ? 
ATOM   1315 N  N   . VAL A 1 182 ? -2.279  -29.363 13.535  1.000 11.886 0 182 VAL A N   1 ? 
ATOM   1316 C  CA  . VAL A 1 182 ? -2.821  -30.679 13.248  1.000 12.625 0 182 VAL A CA  1 ? 
ATOM   1317 C  C   . VAL A 1 182 ? -2.687  -31.528 14.508  1.000 12.703 0 182 VAL A C   1 ? 
ATOM   1318 O  O   . VAL A 1 182 ? -1.612  -31.626 15.061  1.000 13.334 0 182 VAL A O   1 ? 
ATOM   1319 C  CB  . VAL A 1 182 ? -2.146  -31.284 12.011  1.000 13.447 0 182 VAL A CB  1 ? 
ATOM   1320 C  CG1 . VAL A 1 182 ? -2.494  -32.757 11.855  1.000 13.650 0 182 VAL A CG1 1 ? 
ATOM   1321 C  CG2 . VAL A 1 182 ? -2.566  -30.500 10.762  1.000 15.453 0 182 VAL A CG2 1 ? 
ATOM   1322 N  N   . CYS A 1 183 ? -3.798  -32.146 14.908  1.000 12.972 0 183 CYS A N   1 ? 
ATOM   1323 C  CA  . CYS A 1 183 ? -3.791  -32.945 16.119  1.000 14.833 0 183 CYS A CA  1 ? 
ATOM   1324 C  C   . CYS A 1 183 ? -4.548  -34.213 15.800  1.000 17.043 0 183 CYS A C   1 ? 
ATOM   1325 O  O   . CYS A 1 183 ? -5.635  -34.181 15.218  1.000 16.869 0 183 CYS A O   1 ? 
ATOM   1326 C  CB  . CYS A 1 183 ? -4.482  -32.258 17.286  1.000 15.728 0 183 CYS A CB  1 ? 
ATOM   1327 S  SG  . CYS A 1 183 ? -4.242  -30.470 17.422  1.000 18.829 0 183 CYS A SG  1 ? 
ATOM   1328 N  N   . SER A 1 184 ? -3.905  -35.340 16.074  1.000 19.231 0 184 SER A N   1 ? 
ATOM   1329 C  CA  . SER A 1 184 ? -4.484  -36.641 15.767  1.000 22.324 0 184 SER A CA  1 ? 
ATOM   1330 C  C   . SER A 1 184 ? -4.895  -36.723 14.296  1.000 19.323 0 184 SER A C   1 ? 
ATOM   1331 O  O   . SER A 1 184 ? -5.963  -37.248 14.007  1.000 22.981 0 184 SER A O   1 ? 
ATOM   1332 C  CB  . SER A 1 184 ? -5.696  -36.930 16.656  1.000 28.149 0 184 SER A CB  1 ? 
ATOM   1333 O  OG  . SER A 1 184 ? -5.479  -36.554 18.011  1.000 34.148 0 184 SER A OG  1 ? 
ATOM   1334 N  N   . GLY A 1 185 ? -4.098  -36.141 13.379  1.000 18.249 0 185 GLY A N   1 ? 
ATOM   1335 C  CA  . GLY A 1 185 ? -4.308  -36.257 11.941  1.000 18.591 0 185 GLY A CA  1 ? 
ATOM   1336 C  C   . GLY A 1 185 ? -5.461  -35.407 11.390  1.000 19.328 0 185 GLY A C   1 ? 
ATOM   1337 O  O   . GLY A 1 185 ? -5.926  -35.653 10.283  1.000 20.848 0 185 GLY A O   1 ? 
ATOM   1338 N  N   . LYS A 1 186 ? -5.975  -34.465 12.181  1.000 16.528 0 186 LYS A N   1 ? 
ATOM   1339 C  CA  . LYS A 1 186 ? -7.049  -33.594 11.706  1.000 16.266 0 186 LYS A CA  1 ? 
ATOM   1340 C  C   . LYS A 1 186 ? -6.622  -32.144 11.887  1.000 14.362 0 186 LYS A C   1 ? 
ATOM   1341 O  O   . LYS A 1 186 ? -5.925  -31.813 12.837  1.000 13.752 0 186 LYS A O   1 ? 
ATOM   1342 C  CB  . LYS A 1 186 ? -8.342  -33.748 12.507  1.000 20.412 0 186 LYS A CB  1 ? 
ATOM   1343 C  CG  . LYS A 1 186 ? -8.847  -35.201 12.663  1.000 26.305 0 186 LYS A CG  1 ? 
ATOM   1344 C  CD  . LYS A 1 186 ? -9.298  -35.853 11.375  1.000 30.116 0 186 LYS A CD  1 ? 
ATOM   1345 C  CE  . LYS A 1 186 ? -9.702  -37.264 11.736  1.000 36.009 0 186 LYS A CE  1 ? 
ATOM   1346 N  NZ  . LYS A 1 186 ? -10.826 -37.684 10.903  1.000 41.784 0 186 LYS A NZ  1 ? 
ATOM   1347 N  N   . LEU A 1 187 ? -7.143  -31.271 11.023  1.000 13.257 0 187 LEU A N   1 ? 
ATOM   1348 C  CA  . LEU A 1 187 ? -6.882  -29.851 11.217  1.000 13.575 0 187 LEU A CA  1 ? 
ATOM   1349 C  C   . LEU A 1 187 ? -7.724  -29.305 12.352  1.000 14.251 0 187 LEU A C   1 ? 
ATOM   1350 O  O   . LEU A 1 187 ? -8.924  -29.092 12.195  1.000 16.880 0 187 LEU A O   1 ? 
ATOM   1351 C  CB  . LEU A 1 187 ? -7.198  -29.138 9.904   1.000 14.220 0 187 LEU A CB  1 ? 
ATOM   1352 C  CG  . LEU A 1 187 ? -6.896  -27.638 9.891   1.000 14.798 0 187 LEU A CG  1 ? 
ATOM   1353 C  CD1 . LEU A 1 187 ? -5.374  -27.415 9.942   1.000 15.014 0 187 LEU A CD1 1 ? 
ATOM   1354 C  CD2 . LEU A 1 187 ? -7.527  -27.040 8.609   1.000 16.307 0 187 LEU A CD2 1 ? 
ATOM   1355 N  N   . GLN A 1 188 ? -7.070  -28.970 13.453  1.000 11.601 0 188 GLN A N   1 ? 
ATOM   1356 C  CA  . GLN A 1 188 ? -7.796  -28.451 14.587  1.000 13.450 0 188 GLN A CA  1 ? 
ATOM   1357 C  C   . GLN A 1 188 ? -7.640  -26.958 14.797  1.000 12.796 0 188 GLN A C   1 ? 
ATOM   1358 O  O   . GLN A 1 188 ? -8.484  -26.367 15.417  1.000 11.735 0 188 GLN A O   1 ? 
ATOM   1359 C  CB  . GLN A 1 188 ? -7.374  -29.120 15.894  1.000 15.278 0 188 GLN A CB  1 ? 
ATOM   1360 C  CG  . GLN A 1 188 ? -7.832  -30.587 15.949  1.000 16.918 0 188 GLN A CG  1 ? 
ATOM   1361 C  CD  . GLN A 1 188 ? -9.313  -30.793 16.246  1.000 21.853 0 188 GLN A CD  1 ? 
ATOM   1362 O  OE1 . GLN A 1 188 ? -10.100 -29.862 16.403  1.000 22.472 0 188 GLN A OE1 1 ? 
ATOM   1363 N  NE2 . GLN A 1 188 ? -9.721  -32.060 16.358  1.000 20.067 0 188 GLN A NE2 1 ? 
ATOM   1364 N  N   . GLY A 1 189 ? -6.589  -26.362 14.264  1.000 11.059 0 189 GLY A N   1 ? 
ATOM   1365 C  CA  . GLY A 1 189 ? -6.347  -24.955 14.515  1.000 11.031 0 189 GLY A CA  1 ? 
ATOM   1366 C  C   . GLY A 1 189 ? -5.733  -24.268 13.303  1.000 9.200  0 189 GLY A C   1 ? 
ATOM   1367 O  O   . GLY A 1 189 ? -5.174  -24.939 12.402  1.000 10.056 0 189 GLY A O   1 ? 
ATOM   1368 N  N   . ILE A 1 190 ? -5.845  -22.951 13.352  1.000 11.582 0 190 ILE A N   1 ? 
ATOM   1369 C  CA  . ILE A 1 190 ? -5.190  -22.067 12.412  1.000 10.016 0 190 ILE A CA  1 ? 
ATOM   1370 C  C   . ILE A 1 190 ? -4.352  -21.107 13.222  1.000 9.066  0 190 ILE A C   1 ? 
ATOM   1371 O  O   . ILE A 1 190 ? -4.820  -20.482 14.155  1.000 9.473  0 190 ILE A O   1 ? 
ATOM   1372 C  CB  . ILE A 1 190 ? -6.209  -21.295 11.563  1.000 10.704 0 190 ILE A CB  1 ? 
ATOM   1373 C  CG1 . ILE A 1 190 ? -7.149  -22.237 10.853  1.000 12.525 0 190 ILE A CG1 1 ? 
ATOM   1374 C  CG2 . ILE A 1 190 ? -5.546  -20.326 10.580  1.000 12.962 0 190 ILE A CG2 1 ? 
ATOM   1375 C  CD1 . ILE A 1 190 ? -8.380  -21.553 10.348  1.000 15.107 0 190 ILE A CD1 1 ? 
ATOM   1376 N  N   . VAL A 1 191 ? -3.065  -20.929 12.819  1.000 9.376  0 191 VAL A N   1 ? 
ATOM   1377 C  CA  . VAL A 1 191 ? -2.228  -19.948 13.488  1.000 8.870  0 191 VAL A CA  1 ? 
ATOM   1378 C  C   . VAL A 1 191 ? -2.891  -18.560 13.375  1.000 9.425  0 191 VAL A C   1 ? 
ATOM   1379 O  O   . VAL A 1 191 ? -3.039  -18.010 12.283  1.000 9.701  0 191 VAL A O   1 ? 
ATOM   1380 C  CB  . VAL A 1 191 ? -0.793  -19.994 12.945  1.000 9.946  0 191 VAL A CB  1 ? 
ATOM   1381 C  CG1 . VAL A 1 191 ? 0.061   -18.901 13.585  1.000 10.697 0 191 VAL A CG1 1 ? 
ATOM   1382 C  CG2 . VAL A 1 191 ? -0.149  -21.378 13.001  1.000 9.973  0 191 VAL A CG2 1 ? 
ATOM   1383 N  N   . SER A 1 192 ? -3.186  -17.939 14.525  1.000 9.118  0 192 SER A N   1 ? 
ATOM   1384 C  CA  . SER A 1 192 ? -3.957  -16.699 14.577  1.000 9.855  0 192 SER A CA  1 ? 
ATOM   1385 C  C   . SER A 1 192 ? -3.182  -15.552 15.226  1.000 11.167 0 192 SER A C   1 ? 
ATOM   1386 O  O   . SER A 1 192 ? -2.851  -14.597 14.553  1.000 11.984 0 192 SER A O   1 ? 
ATOM   1387 C  CB  . SER A 1 192 ? -5.287  -16.922 15.190  1.000 11.458 0 192 SER A CB  1 ? 
ATOM   1388 O  OG  . SER A 1 192 ? -6.073  -15.757 15.165  1.000 12.096 0 192 SER A OG  1 ? 
ATOM   1389 N  N   . TRP A 1 193 ? -2.894  -15.618 16.529  1.000 11.670 0 193 TRP A N   1 ? 
ATOM   1390 C  CA  . TRP A 1 193 ? -2.249  -14.476 17.172  1.000 12.342 0 193 TRP A CA  1 ? 
ATOM   1391 C  C   . TRP A 1 193 ? -1.508  -14.914 18.422  1.000 14.351 0 193 TRP A C   1 ? 
ATOM   1392 O  O   . TRP A 1 193 ? -1.525  -16.062 18.828  1.000 11.877 0 193 TRP A O   1 ? 
ATOM   1393 C  CB  . TRP A 1 193 ? -3.286  -13.385 17.421  1.000 13.287 0 193 TRP A CB  1 ? 
ATOM   1394 C  CG  . TRP A 1 193 ? -4.391  -13.698 18.377  1.000 13.129 0 193 TRP A CG  1 ? 
ATOM   1395 C  CD1 . TRP A 1 193 ? -5.585  -14.303 18.072  1.000 12.960 0 193 TRP A CD1 1 ? 
ATOM   1396 C  CD2 . TRP A 1 193 ? -4.486  -13.311 19.771  1.000 15.606 0 193 TRP A CD2 1 ? 
ATOM   1397 N  NE1 . TRP A 1 193 ? -6.394  -14.357 19.168  1.000 14.578 0 193 TRP A NE1 1 ? 
ATOM   1398 C  CE2 . TRP A 1 193 ? -5.757  -13.743 20.220  1.000 14.865 0 193 TRP A CE2 1 ? 
ATOM   1399 C  CE3 . TRP A 1 193 ? -3.612  -12.659 20.661  1.000 16.113 0 193 TRP A CE3 1 ? 
ATOM   1400 C  CZ2 . TRP A 1 193 ? -6.188  -13.543 21.541  1.000 16.855 0 193 TRP A CZ2 1 ? 
ATOM   1401 C  CZ3 . TRP A 1 193 ? -4.049  -12.478 21.958  1.000 17.176 0 193 TRP A CZ3 1 ? 
ATOM   1402 C  CH2 . TRP A 1 193 ? -5.315  -12.886 22.371  1.000 16.438 0 193 TRP A CH2 1 ? 
ATOM   1403 N  N   . GLY A 1 194 ? -0.875  -13.941 19.072  1.000 14.304 0 194 GLY A N   1 ? 
ATOM   1404 C  CA  . GLY A 1 194 ? -0.310  -14.140 20.385  1.000 16.079 0 194 GLY A CA  1 ? 
ATOM   1405 C  C   . GLY A 1 194 ? 0.417   -12.850 20.717  1.000 17.241 0 194 GLY A C   1 ? 
ATOM   1406 O  O   . GLY A 1 194 ? 0.458   -11.961 19.868  1.000 20.848 0 194 GLY A O   1 ? 
ATOM   1407 N  N   . SER A 1 195 ? 0.845   -12.693 21.949  1.000 16.501 0 195 SER A N   1 ? 
ATOM   1408 C  CA  . SER A 1 195 ? 1.573   -11.490 22.329  1.000 18.240 0 195 SER A CA  1 ? 
ATOM   1409 C  C   . SER A 1 195 ? 3.063   -11.754 22.177  1.000 17.386 0 195 SER A C   1 ? 
ATOM   1410 O  O   . SER A 1 195 ? 3.641   -12.511 22.947  1.000 20.396 0 195 SER A O   1 ? 
ATOM   1411 C  CB  . SER A 1 195 ? 1.237   -11.077 23.709  1.000 22.419 0 195 SER A CB  1 ? 
ATOM   1412 O  OG  . SER A 1 195 ? 1.885   -9.823  23.921  1.000 27.839 0 195 SER A OG  1 ? 
ATOM   1413 N  N   . GLY A 1 196 ? 3.655   -11.212 21.122  1.000 16.674 0 196 GLY A N   1 ? 
ATOM   1414 C  CA  . GLY A 1 196 ? 5.023   -11.511 20.781  1.000 16.503 0 196 GLY A CA  1 ? 
ATOM   1415 C  C   . GLY A 1 196 ? 5.093   -12.969 20.317  1.000 17.975 0 196 GLY A C   1 ? 
ATOM   1416 O  O   . GLY A 1 196 ? 4.047   -13.499 19.935  1.000 19.201 0 196 GLY A O   1 ? 
ATOM   1417 N  N   . CYS A 1 197 ? 6.275   -13.573 20.430  1.000 17.952 0 197 CYS A N   1 ? 
ATOM   1418 C  CA  . CYS A 1 197 ? 6.453   -14.983 20.139  1.000 17.554 0 197 CYS A CA  1 ? 
ATOM   1419 C  C   . CYS A 1 197 ? 7.297   -15.613 21.234  1.000 20.663 0 197 CYS A C   1 ? 
ATOM   1420 O  O   . CYS A 1 197 ? 8.397   -15.135 21.541  1.000 20.342 0 197 CYS A O   1 ? 
ATOM   1421 C  CB  . CYS A 1 197 ? 7.141   -15.190 18.806  1.000 18.098 0 197 CYS A CB  1 ? 
ATOM   1422 S  SG  . CYS A 1 197 ? 6.306   -14.292 17.468  1.000 19.091 0 197 CYS A SG  1 ? 
ATOM   1423 N  N   . ALA A 1 198 ? 6.838   -16.755 21.723  1.000 18.252 0 198 ALA A N   1 ? 
ATOM   1424 C  CA  . ALA A 1 198 ? 7.653   -17.582 22.606  1.000 17.436 0 198 ALA A CA  1 ? 
ATOM   1425 C  C   . ALA A 1 198 ? 7.922   -16.889 23.938  1.000 20.330 0 198 ALA A C   1 ? 
ATOM   1426 O  O   . ALA A 1 198 ? 8.901   -17.287 24.588  1.000 21.819 0 198 ALA A O   1 ? 
ATOM   1427 C  CB  . ALA A 1 198 ? 8.940   -18.039 21.979  1.000 17.194 0 198 ALA A CB  1 ? 
ATOM   1428 N  N   . GLN A 1 199 ? 7.068   -15.911 24.311  1.000 20.848 0 199 GLN A N   1 ? 
ATOM   1429 C  CA  . GLN A 1 199 ? 7.226   -15.209 25.576  1.000 23.040 0 199 GLN A CA  1 ? 
ATOM   1430 C  C   . GLN A 1 199 ? 6.666   -16.076 26.706  1.000 21.886 0 199 GLN A C   1 ? 
ATOM   1431 O  O   . GLN A 1 199 ? 5.734   -16.836 26.542  1.000 21.104 0 199 GLN A O   1 ? 
ATOM   1432 C  CB  . GLN A 1 199 ? 6.510   -13.860 25.517  1.000 25.343 0 199 GLN A CB  1 ? 
ATOM   1433 C  CG  . GLN A 1 199 ? 7.021   -12.948 24.410  1.000 31.848 0 199 GLN A CG  1 ? 
ATOM   1434 C  CD  . GLN A 1 199 ? 8.149   -12.034 24.819  1.000 40.621 0 199 GLN A CD  1 ? 
ATOM   1435 O  OE1 . GLN A 1 199 ? 8.143   -10.843 24.484  1.000 58.761 0 199 GLN A OE1 1 ? 
ATOM   1436 N  NE2 . GLN A 1 199 ? 9.131   -12.574 25.524  1.000 41.325 0 199 GLN A NE2 1 ? 
ATOM   1437 N  N   . LYS A 1 200 ? 7.195   -15.893 27.917  1.000 26.553 0 200 LYS A N   1 ? 
ATOM   1438 C  CA  . LYS A 1 200 ? 6.668   -16.602 29.076  1.000 27.266 0 200 LYS A CA  1 ? 
ATOM   1439 C  C   . LYS A 1 200 ? 5.241   -16.132 29.334  1.000 23.673 0 200 LYS A C   1 ? 
ATOM   1440 O  O   . LYS A 1 200 ? 4.940   -14.957 29.194  1.000 23.540 0 200 LYS A O   1 ? 
ATOM   1441 C  CB  . LYS A 1 200 ? 7.667   -16.322 30.217  1.000 33.662 0 200 LYS A CB  1 ? 
ATOM   1442 C  CG  . LYS A 1 200 ? 7.350   -16.831 31.604  1.000 42.832 0 200 LYS A CG  1 ? 
ATOM   1443 C  CD  . LYS A 1 200 ? 8.465   -16.454 32.581  1.000 50.728 0 200 LYS A CD  1 ? 
ATOM   1444 C  CE  . LYS A 1 200 ? 8.032   -16.394 34.018  1.000 57.421 0 200 LYS A CE  1 ? 
ATOM   1445 N  NZ  . LYS A 1 200 ? 7.596   -17.706 34.501  1.000 61.072 0 200 LYS A NZ  1 ? 
ATOM   1446 N  N   . ASN A 1 201 ? 4.361   -17.091 29.651  1.000 22.660 0 201 ASN A N   1 ? 
ATOM   1447 C  CA  . ASN A 1 201 ? 2.961   -16.887 29.986  1.000 25.827 0 201 ASN A CA  1 ? 
ATOM   1448 C  C   . ASN A 1 201 ? 2.139   -16.327 28.824  1.000 22.825 0 201 ASN A C   1 ? 
ATOM   1449 O  O   . ASN A 1 201 ? 1.022   -15.878 29.040  1.000 22.991 0 201 ASN A O   1 ? 
ATOM   1450 C  CB  . ASN A 1 201 ? 2.789   -15.991 31.212  1.000 29.872 0 201 ASN A CB  1 ? 
ATOM   1451 C  CG  . ASN A 1 201 ? 3.483   -16.552 32.428  1.000 41.532 0 201 ASN A CG  1 ? 
ATOM   1452 O  OD1 . ASN A 1 201 ? 4.298   -15.869 33.063  1.000 45.770 0 201 ASN A OD1 1 ? 
ATOM   1453 N  ND2 . ASN A 1 201 ? 3.153   -17.787 32.772  1.000 43.747 0 201 ASN A ND2 1 ? 
ATOM   1454 N  N   . LYS A 1 202 ? 2.687   -16.331 27.595  1.000 21.355 0 202 LYS A N   1 ? 
ATOM   1455 C  CA  . LYS A 1 202 ? 1.954   -15.821 26.460  1.000 19.887 0 202 LYS A CA  1 ? 
ATOM   1456 C  C   . LYS A 1 202 ? 1.979   -16.893 25.364  1.000 18.689 0 202 LYS A C   1 ? 
ATOM   1457 O  O   . LYS A 1 202 ? 2.687   -16.779 24.386  1.000 18.620 0 202 LYS A O   1 ? 
ATOM   1458 C  CB  . LYS A 1 202 ? 2.507   -14.469 26.001  1.000 21.022 0 202 LYS A CB  1 ? 
ATOM   1459 C  CG  . LYS A 1 202 ? 2.385   -13.372 27.059  1.000 20.973 0 202 LYS A CG  1 ? 
ATOM   1460 C  CD  . LYS A 1 202 ? 0.950   -12.983 27.351  1.000 26.437 0 202 LYS A CD  1 ? 
ATOM   1461 C  CE  . LYS A 1 202 ? 0.837   -12.051 28.495  1.000 31.708 0 202 LYS A CE  1 ? 
ATOM   1462 N  NZ  . LYS A 1 202 ? -0.513  -11.481 28.409  1.000 36.299 0 202 LYS A NZ  1 ? 
ATOM   1463 N  N   . PRO A 1 203 ? 1.170   -17.962 25.469  1.000 17.744 0 203 PRO A N   1 ? 
ATOM   1464 C  CA  . PRO A 1 203 ? 1.215   -19.001 24.435  1.000 15.846 0 203 PRO A CA  1 ? 
ATOM   1465 C  C   . PRO A 1 203 ? 0.515   -18.489 23.165  1.000 14.323 0 203 PRO A C   1 ? 
ATOM   1466 O  O   . PRO A 1 203 ? -0.101  -17.427 23.148  1.000 15.311 0 203 PRO A O   1 ? 
ATOM   1467 C  CB  . PRO A 1 203 ? 0.495   -20.122 25.072  1.000 18.465 0 203 PRO A CB  1 ? 
ATOM   1468 C  CG  . PRO A 1 203 ? -0.537  -19.413 25.890  1.000 19.717 0 203 PRO A CG  1 ? 
ATOM   1469 C  CD  . PRO A 1 203 ? 0.191   -18.245 26.520  1.000 18.465 0 203 PRO A CD  1 ? 
ATOM   1470 N  N   . GLY A 1 204 ? 0.676   -19.255 22.101  1.000 13.892 0 204 GLY A N   1 ? 
ATOM   1471 C  CA  . GLY A 1 204 ? -0.028  -19.007 20.842  1.000 12.940 0 204 GLY A CA  1 ? 
ATOM   1472 C  C   . GLY A 1 204 ? -1.533  -19.225 20.969  1.000 12.294 0 204 GLY A C   1 ? 
ATOM   1473 O  O   . GLY A 1 204 ? -1.991  -20.063 21.735  1.000 13.079 0 204 GLY A O   1 ? 
ATOM   1474 N  N   . VAL A 1 205 ? -2.300  -18.401 20.248  1.000 11.489 0 205 VAL A N   1 ? 
ATOM   1475 C  CA  . VAL A 1 205 ? -3.742  -18.481 20.173  1.000 11.168 0 205 VAL A CA  1 ? 
ATOM   1476 C  C   . VAL A 1 205 ? -4.121  -18.870 18.750  1.000 12.481 0 205 VAL A C   1 ? 
ATOM   1477 O  O   . VAL A 1 205 ? -3.571  -18.313 17.783  1.000 13.193 0 205 VAL A O   1 ? 
ATOM   1478 C  CB  . VAL A 1 205 ? -4.426  -17.175 20.606  1.000 12.785 0 205 VAL A CB  1 ? 
ATOM   1479 C  CG1 . VAL A 1 205 ? -5.918  -17.346 20.627  1.000 13.402 0 205 VAL A CG1 1 ? 
ATOM   1480 C  CG2 . VAL A 1 205 ? -3.933  -16.724 21.964  1.000 13.762 0 205 VAL A CG2 1 ? 
ATOM   1481 N  N   . TYR A 1 206 ? -5.039  -19.813 18.638  1.000 10.429 0 206 TYR A N   1 ? 
ATOM   1482 C  CA  . TYR A 1 206 ? -5.378  -20.497 17.397  1.000 10.821 0 206 TYR A CA  1 ? 
ATOM   1483 C  C   . TYR A 1 206 ? -6.881  -20.494 17.197  1.000 12.435 0 206 TYR A C   1 ? 
ATOM   1484 O  O   . TYR A 1 206 ? -7.657  -20.653 18.144  1.000 13.337 0 206 TYR A O   1 ? 
ATOM   1485 C  CB  . TYR A 1 206 ? -4.817  -21.919 17.442  1.000 10.453 0 206 TYR A CB  1 ? 
ATOM   1486 C  CG  . TYR A 1 206 ? -3.312  -21.925 17.634  1.000 10.708 0 206 TYR A CG  1 ? 
ATOM   1487 C  CD1 . TYR A 1 206 ? -2.512  -21.779 16.548  1.000 10.967 0 206 TYR A CD1 1 ? 
ATOM   1488 C  CD2 . TYR A 1 206 ? -2.711  -22.027 18.878  1.000 12.127 0 206 TYR A CD2 1 ? 
ATOM   1489 C  CE1 . TYR A 1 206 ? -1.127  -21.740 16.649  1.000 10.659 0 206 TYR A CE1 1 ? 
ATOM   1490 C  CE2 . TYR A 1 206 ? -1.341  -21.983 19.010  1.000 11.199 0 206 TYR A CE2 1 ? 
ATOM   1491 C  CZ  . TYR A 1 206 ? -0.537  -21.853 17.890  1.000 11.621 0 206 TYR A CZ  1 ? 
ATOM   1492 O  OH  . TYR A 1 206 ? 0.812   -21.771 18.009  1.000 12.295 0 206 TYR A OH  1 ? 
ATOM   1493 N  N   . THR A 1 207 ? -7.265  -20.331 15.926  1.000 10.285 0 207 THR A N   1 ? 
ATOM   1494 C  CA  . THR A 1 207 ? -8.665  -20.412 15.571  1.000 10.409 0 207 THR A CA  1 ? 
ATOM   1495 C  C   . THR A 1 207 ? -9.087  -21.863 15.786  1.000 10.778 0 207 THR A C   1 ? 
ATOM   1496 O  O   . THR A 1 207 ? -8.447  -22.771 15.274  1.000 11.701 0 207 THR A O   1 ? 
ATOM   1497 C  CB  . THR A 1 207 ? -8.886  -19.990 14.120  1.000 11.118 0 207 THR A CB  1 ? 
ATOM   1498 O  OG1 . THR A 1 207 ? -8.319  -18.690 13.990  1.000 12.956 0 207 THR A OG1 1 ? 
ATOM   1499 C  CG2 . THR A 1 207 ? -10.375 -19.961 13.854  1.000 11.941 0 207 THR A CG2 1 ? 
ATOM   1500 N  N   . LYS A 1 208 ? -10.232 -22.063 16.420  1.000 11.843 0 208 LYS A N   1 ? 
ATOM   1501 C  CA  . LYS A 1 208 ? -10.742 -23.385 16.738  1.000 11.754 0 208 LYS A CA  1 ? 
ATOM   1502 C  C   . LYS A 1 208 ? -11.568 -23.893 15.564  1.000 12.727 0 208 LYS A C   1 ? 
ATOM   1503 O  O   . LYS A 1 208 ? -12.771 -23.660 15.492  1.000 12.995 0 208 LYS A O   1 ? 
ATOM   1504 C  CB  . LYS A 1 208 ? -11.633 -23.286 17.971  1.000 14.821 0 208 LYS A CB  1 ? 
ATOM   1505 C  CG  . LYS A 1 208 ? -11.965 -24.601 18.567  1.000 17.568 0 208 LYS A CG  1 ? 
ATOM   1506 C  CD  . LYS A 1 208 ? -12.551 -24.395 19.965  1.000 22.267 0 208 LYS A CD  1 ? 
ATOM   1507 C  CE  . LYS A 1 208 ? -12.933 -25.702 20.586  1.000 31.749 0 208 LYS A CE  1 ? 
ATOM   1508 N  NZ  . LYS A 1 208 ? -13.276 -25.543 22.006  1.000 37.478 0 208 LYS A NZ  1 ? 
ATOM   1509 N  N   . VAL A 1 209 ? -10.944 -24.616 14.662  1.000 10.939 0 209 VAL A N   1 ? 
ATOM   1510 C  CA  . VAL A 1 209 ? -11.530 -25.087 13.410  1.000 11.820 0 209 VAL A CA  1 ? 
ATOM   1511 C  C   . VAL A 1 209 ? -12.789 -25.934 13.578  1.000 12.591 0 209 VAL A C   1 ? 
ATOM   1512 O  O   . VAL A 1 209 ? -13.733 -25.794 12.813  1.000 13.136 0 209 VAL A O   1 ? 
ATOM   1513 C  CB  . VAL A 1 209 ? -10.477 -25.854 12.601  1.000 12.279 0 209 VAL A CB  1 ? 
ATOM   1514 C  CG1 . VAL A 1 209 ? -11.120 -26.526 11.409  1.000 13.850 0 209 VAL A CG1 1 ? 
ATOM   1515 C  CG2 . VAL A 1 209 ? -9.376  -24.909 12.164  1.000 12.609 0 209 VAL A CG2 1 ? 
ATOM   1516 N  N   . CYS A 1 210 ? -12.858 -26.736 14.645  1.000 12.744 0 210 CYS A N   1 ? 
ATOM   1517 C  CA  . CYS A 1 210 ? -14.043 -27.580 14.829  1.000 15.135 0 210 CYS A CA  1 ? 
ATOM   1518 C  C   . CYS A 1 210 ? -15.345 -26.784 14.927  1.000 15.480 0 210 CYS A C   1 ? 
ATOM   1519 O  O   . CYS A 1 210 ? -16.401 -27.363 14.643  1.000 18.417 0 210 CYS A O   1 ? 
ATOM   1520 C  CB  . CYS A 1 210 ? -13.860 -28.492 16.019  1.000 15.494 0 210 CYS A CB  1 ? 
ATOM   1521 S  SG  . CYS A 1 210 ? -13.760 -27.607 17.586  1.000 17.900 0 210 CYS A SG  1 ? 
ATOM   1522 N  N   . ASN A 1 211 ? -15.319 -25.499 15.313  1.000 13.427 0 211 ASN A N   1 ? 
ATOM   1523 C  CA  . ASN A 1 211 ? -16.511 -24.661 15.328  1.000 14.403 0 211 ASN A CA  1 ? 
ATOM   1524 C  C   . ASN A 1 211 ? -16.973 -24.219 13.925  1.000 15.062 0 211 ASN A C   1 ? 
ATOM   1525 O  O   . ASN A 1 211 ? -18.084 -23.693 13.773  1.000 19.641 0 211 ASN A O   1 ? 
ATOM   1526 C  CB  . ASN A 1 211 ? -16.279 -23.406 16.171  1.000 14.754 0 211 ASN A CB  1 ? 
ATOM   1527 C  CG  . ASN A 1 211 ? -16.155 -23.677 17.656  1.000 18.333 0 211 ASN A CG  1 ? 
ATOM   1528 O  OD1 . ASN A 1 211 ? -16.247 -24.811 18.103  1.000 19.283 0 211 ASN A OD1 1 ? 
ATOM   1529 N  ND2 . ASN A 1 211 ? -15.928 -22.639 18.449  1.000 21.691 0 211 ASN A ND2 1 ? 
ATOM   1530 N  N   . TYR A 1 212 ? -16.183 -24.480 12.887  1.000 13.454 0 212 TYR A N   1 ? 
ATOM   1531 C  CA  . TYR A 1 212 ? -16.420 -23.889 11.572  1.000 12.971 0 212 TYR A CA  1 ? 
ATOM   1532 C  C   . TYR A 1 212 ? -16.729 -24.938 10.515  1.000 15.346 0 212 TYR A C   1 ? 
ATOM   1533 O  O   . TYR A 1 212 ? -16.914 -24.590 9.366   1.000 14.036 0 212 TYR A O   1 ? 
ATOM   1534 C  CB  . TYR A 1 212 ? -15.215 -23.076 11.115  1.000 14.089 0 212 TYR A CB  1 ? 
ATOM   1535 C  CG  . TYR A 1 212 ? -15.010 -21.905 12.045  1.000 12.411 0 212 TYR A CG  1 ? 
ATOM   1536 C  CD1 . TYR A 1 212 ? -15.799 -20.778 11.940  1.000 13.261 0 212 TYR A CD1 1 ? 
ATOM   1537 C  CD2 . TYR A 1 212 ? -14.079 -21.970 13.047  1.000 12.945 0 212 TYR A CD2 1 ? 
ATOM   1538 C  CE1 . TYR A 1 212 ? -15.666 -19.751 12.836  1.000 13.664 0 212 TYR A CE1 1 ? 
ATOM   1539 C  CE2 . TYR A 1 212 ? -13.919 -20.937 13.926  1.000 11.571 0 212 TYR A CE2 1 ? 
ATOM   1540 C  CZ  . TYR A 1 212 ? -14.710 -19.822 13.815  1.000 13.061 0 212 TYR A CZ  1 ? 
ATOM   1541 O  OH  . TYR A 1 212 ? -14.595 -18.761 14.661  1.000 13.667 0 212 TYR A OH  1 ? 
ATOM   1542 N  N   . VAL A 1 213 ? -16.767 -26.202 10.904  1.000 15.107 0 213 VAL A N   1 ? 
ATOM   1543 C  CA  . VAL A 1 213 ? -16.870 -27.237 9.896   1.000 16.009 0 213 VAL A CA  1 ? 
ATOM   1544 C  C   . VAL A 1 213 ? -18.156 -27.085 9.086   1.000 15.521 0 213 VAL A C   1 ? 
ATOM   1545 O  O   . VAL A 1 213 ? -18.120 -27.303 7.891   1.000 13.708 0 213 VAL A O   1 ? 
ATOM   1546 C  CB  . VAL A 1 213 ? -16.721 -28.612 10.560  1.000 18.715 0 213 VAL A CB  1 ? 
ATOM   1547 C  CG1 . VAL A 1 213 ? -17.104 -29.721 9.588   1.000 21.414 0 213 VAL A CG1 1 ? 
ATOM   1548 C  CG2 . VAL A 1 213 ? -15.291 -28.777 11.038  1.000 20.617 0 213 VAL A CG2 1 ? 
ATOM   1549 N  N   . SER A 1 214 ? -19.276 -26.734 9.713   1.000 15.554 0 214 SER A N   1 ? 
ATOM   1550 C  CA  . SER A 1 214 ? -20.519 -26.630 8.984   1.000 18.726 0 214 SER A CA  1 ? 
ATOM   1551 C  C   . SER A 1 214 ? -20.453 -25.517 7.950   1.000 16.834 0 214 SER A C   1 ? 
ATOM   1552 O  O   . SER A 1 214 ? -20.890 -25.691 6.821   1.000 15.695 0 214 SER A O   1 ? 
ATOM   1553 C  CB  . SER A 1 214 ? -21.667 -26.407 9.928   1.000 24.083 0 214 SER A CB  1 ? 
ATOM   1554 O  OG  . SER A 1 214 ? -21.850 -27.622 10.637  1.000 30.706 0 214 SER A OG  1 ? 
ATOM   1555 N  N   . TRP A 1 215 ? -19.807 -24.406 8.319   1.000 14.472 0 215 TRP A N   1 ? 
ATOM   1556 C  CA  . TRP A 1 215 ? -19.693 -23.287 7.395   1.000 13.479 0 215 TRP A CA  1 ? 
ATOM   1557 C  C   . TRP A 1 215 ? -18.747 -23.666 6.257   1.000 12.696 0 215 TRP A C   1 ? 
ATOM   1558 O  O   . TRP A 1 215 ? -18.999 -23.343 5.109   1.000 13.125 0 215 TRP A O   1 ? 
ATOM   1559 C  CB  . TRP A 1 215 ? -19.224 -22.010 8.139   1.000 13.082 0 215 TRP A CB  1 ? 
ATOM   1560 C  CG  . TRP A 1 215 ? -18.806 -20.865 7.239   1.000 11.593 0 215 TRP A CG  1 ? 
ATOM   1561 C  CD1 . TRP A 1 215 ? -19.618 -20.025 6.521   1.000 11.488 0 215 TRP A CD1 1 ? 
ATOM   1562 C  CD2 . TRP A 1 215 ? -17.473 -20.429 6.949   1.000 12.541 0 215 TRP A CD2 1 ? 
ATOM   1563 N  NE1 . TRP A 1 215 ? -18.883 -19.134 5.802   1.000 13.211 0 215 TRP A NE1 1 ? 
ATOM   1564 C  CE2 . TRP A 1 215 ? -17.553 -19.376 6.014   1.000 12.611 0 215 TRP A CE2 1 ? 
ATOM   1565 C  CE3 . TRP A 1 215 ? -16.205 -20.894 7.315   1.000 12.412 0 215 TRP A CE3 1 ? 
ATOM   1566 C  CZ2 . TRP A 1 215 ? -16.428 -18.719 5.535   1.000 13.341 0 215 TRP A CZ2 1 ? 
ATOM   1567 C  CZ3 . TRP A 1 215 ? -15.093 -20.257 6.819   1.000 13.942 0 215 TRP A CZ3 1 ? 
ATOM   1568 C  CH2 . TRP A 1 215 ? -15.194 -19.200 5.932   1.000 13.530 0 215 TRP A CH2 1 ? 
ATOM   1569 N  N   . ILE A 1 216 ? -17.635 -24.306 6.571   1.000 11.773 0 216 ILE A N   1 ? 
ATOM   1570 C  CA  . ILE A 1 216 ? -16.740 -24.729 5.505   1.000 13.707 0 216 ILE A CA  1 ? 
ATOM   1571 C  C   . ILE A 1 216 ? -17.435 -25.670 4.527   1.000 15.151 0 216 ILE A C   1 ? 
ATOM   1572 O  O   . ILE A 1 216 ? -17.419 -25.452 3.332   1.000 13.340 0 216 ILE A O   1 ? 
ATOM   1573 C  CB  . ILE A 1 216 ? -15.509 -25.394 6.104   1.000 14.186 0 216 ILE A CB  1 ? 
ATOM   1574 C  CG1 . ILE A 1 216 ? -14.666 -24.382 6.893   1.000 15.574 0 216 ILE A CG1 1 ? 
ATOM   1575 C  CG2 . ILE A 1 216 ? -14.716 -26.092 5.003   1.000 14.845 0 216 ILE A CG2 1 ? 
ATOM   1576 C  CD1 . ILE A 1 216 ? -13.579 -25.005 7.715   1.000 16.366 0 216 ILE A CD1 1 ? 
ATOM   1577 N  N   . LYS A 1 217 ? -18.101 -26.706 5.040   1.000 14.697 0 217 LYS A N   1 ? 
ATOM   1578 C  CA  . LYS A 1 217 ? -18.747 -27.654 4.139   1.000 17.232 0 217 LYS A CA  1 ? 
ATOM   1579 C  C   . LYS A 1 217 ? -19.824 -26.993 3.289   1.000 18.470 0 217 LYS A C   1 ? 
ATOM   1580 O  O   . LYS A 1 217 ? -19.928 -27.265 2.088   1.000 18.924 0 217 LYS A O   1 ? 
ATOM   1581 C  CB  . LYS A 1 217 ? -19.314 -28.794 4.985   1.000 18.317 0 217 LYS A CB  1 ? 
ATOM   1582 C  CG  . LYS A 1 217 ? -18.221 -29.723 5.476   1.000 25.185 0 217 LYS A CG  1 ? 
ATOM   1583 C  CD  . LYS A 1 217 ? -18.833 -30.825 6.338   1.000 32.883 0 217 LYS A CD  1 ? 
ATOM   1584 C  CE  . LYS A 1 217 ? -17.886 -31.853 6.874   1.000 41.695 0 217 LYS A CE  1 ? 
ATOM   1585 N  NZ  . LYS A 1 217 ? -17.281 -32.633 5.792   1.000 48.325 0 217 LYS A NZ  1 ? 
ATOM   1586 N  N   . GLN A 1 218 ? -20.617 -26.122 3.897   1.000 17.055 0 218 GLN A N   1 ? 
ATOM   1587 C  CA  . GLN A 1 218 ? -21.673 -25.447 3.161   1.000 18.181 0 218 GLN A CA  1 ? 
ATOM   1588 C  C   . GLN A 1 218 ? -21.103 -24.561 2.062   1.000 17.547 0 218 GLN A C   1 ? 
ATOM   1589 O  O   . GLN A 1 218 ? -21.634 -24.483 0.948   1.000 19.741 0 218 GLN A O   1 ? 
ATOM   1590 C  CB  . GLN A 1 218 ? -22.600 -24.654 4.087   1.000 23.758 0 218 GLN A CB  1 ? 
ATOM   1591 C  CG  . GLN A 1 218 ? -23.401 -25.573 5.004   1.000 31.683 0 218 GLN A CG  1 ? 
ATOM   1592 C  CD  . GLN A 1 218 ? -24.416 -24.843 5.861   1.000 43.639 0 218 GLN A CD  1 ? 
ATOM   1593 O  OE1 . GLN A 1 218 ? -24.309 -24.779 7.094   1.000 53.453 0 218 GLN A OE1 1 ? 
ATOM   1594 N  NE2 . GLN A 1 218 ? -25.416 -24.271 5.204   1.000 52.195 0 218 GLN A NE2 1 ? 
ATOM   1595 N  N   . THR A 1 219 ? -20.022 -23.842 2.389   1.000 13.783 0 219 THR A N   1 ? 
ATOM   1596 C  CA  . THR A 1 219 ? -19.450 -22.892 1.454   1.000 15.776 0 219 THR A CA  1 ? 
ATOM   1597 C  C   . THR A 1 219 ? -18.836 -23.636 0.265   1.000 15.891 0 219 THR A C   1 ? 
ATOM   1598 O  O   . THR A 1 219 ? -19.003 -23.196 -0.861  1.000 16.986 0 219 THR A O   1 ? 
ATOM   1599 C  CB  . THR A 1 219 ? -18.443 -22.003 2.194   1.000 15.175 0 219 THR A CB  1 ? 
ATOM   1600 O  OG1 . THR A 1 219 ? -19.123 -21.310 3.251   1.000 14.747 0 219 THR A OG1 1 ? 
ATOM   1601 C  CG2 . THR A 1 219 ? -17.704 -21.087 1.222   1.000 17.712 0 219 THR A CG2 1 ? 
ATOM   1602 N  N   . ILE A 1 220 ? -18.072 -24.707 0.505   1.000 15.889 0 220 ILE A N   1 ? 
ATOM   1603 C  CA  . ILE A 1 220 ? -17.453 -25.458 -0.583  1.000 18.721 0 220 ILE A CA  1 ? 
ATOM   1604 C  C   . ILE A 1 220 ? -18.488 -26.127 -1.461  1.000 20.384 0 220 ILE A C   1 ? 
ATOM   1605 O  O   . ILE A 1 220 ? -18.258 -26.313 -2.655  1.000 20.526 0 220 ILE A O   1 ? 
ATOM   1606 C  CB  . ILE A 1 220 ? -16.482 -26.494 -0.001  1.000 22.329 0 220 ILE A CB  1 ? 
ATOM   1607 C  CG1 . ILE A 1 220 ? -15.322 -25.778 0.567   1.000 23.932 0 220 ILE A CG1 1 ? 
ATOM   1608 C  CG2 . ILE A 1 220 ? -16.116 -27.558 -1.043  1.000 27.746 0 220 ILE A CG2 1 ? 
ATOM   1609 C  CD1 . ILE A 1 220 ? -14.404 -26.708 1.321   1.000 26.778 0 220 ILE A CD1 1 ? 
ATOM   1610 N  N   . ALA A 1 221 ? -19.657 -26.409 -0.923  1.000 18.833 0 221 ALA A N   1 ? 
ATOM   1611 C  CA  . ALA A 1 221 ? -20.654 -27.099 -1.732  1.000 19.981 0 221 ALA A CA  1 ? 
ATOM   1612 C  C   . ALA A 1 221 ? -21.416 -26.144 -2.638  1.000 22.333 0 221 ALA A C   1 ? 
ATOM   1613 O  O   . ALA A 1 221 ? -22.255 -26.578 -3.435  1.000 23.997 0 221 ALA A O   1 ? 
ATOM   1614 C  CB  . ALA A 1 221 ? -21.582 -27.817 -0.812  1.000 21.777 0 221 ALA A CB  1 ? 
ATOM   1615 N  N   . SER A 1 222 ? -21.153 -24.844 -2.526  1.000 19.518 0 222 SER A N   1 ? 
ATOM   1616 C  CA  . SER A 1 222 ? -21.909 -23.828 -3.226  1.000 21.038 0 222 SER A CA  1 ? 
ATOM   1617 C  C   . SER A 1 222 ? -21.044 -22.873 -4.015  1.000 17.920 0 222 SER A C   1 ? 
ATOM   1618 O  O   . SER A 1 222 ? -21.605 -21.926 -4.541  1.000 19.738 0 222 SER A O   1 ? 
ATOM   1619 C  CB  . SER A 1 222 ? -22.718 -23.016 -2.238  1.000 23.915 0 222 SER A CB  1 ? 
ATOM   1620 O  OG  . SER A 1 222 ? -23.420 -23.852 -1.340  1.000 32.765 0 222 SER A OG  1 ? 
ATOM   1621 N  N   . ASN A 1 223 ? -19.710 -23.081 -4.039  1.000 17.208 0 223 ASN A N   1 ? 
ATOM   1622 C  CA  . ASN A 1 223 ? -18.780 -22.155 -4.634  1.000 18.413 0 223 ASN A CA  1 ? 
ATOM   1623 C  C   . ASN A 1 223 ? -17.696 -22.923 -5.394  1.000 17.638 0 223 ASN A C   1 ? 
ATOM   1624 O  O   . ASN A 1 223 ? -16.938 -22.221 -6.089  1.000 20.615 0 223 ASN A O   1 ? 
ATOM   1625 C  CB  . ASN A 1 223 ? -18.136 -21.254 -3.568  1.000 18.825 0 223 ASN A CB  1 ? 
ATOM   1626 C  CG  . ASN A 1 223 ? -19.106 -20.261 -3.001  1.000 19.246 0 223 ASN A CG  1 ? 
ATOM   1627 O  OD1 . ASN A 1 223 ? -19.227 -19.153 -3.533  1.000 22.307 0 223 ASN A OD1 1 ? 
ATOM   1628 N  ND2 . ASN A 1 223 ? -19.748 -20.600 -1.897  1.000 20.059 0 223 ASN A ND2 1 ? 
ATOM   1629 O  OXT . ASN A 1 223 ? -17.643 -24.156 -5.276  1.000 20.078 0 223 ASN A OXT 1 ? 
HETATM 1630 CA CA  . CA  B 2 .   ? 10.541  -24.490 -3.484  1.000 14.654 0 301 CA  A CA  1 ? 
HETATM 1631 C  C1  . BEN C 3 .   ? 1.920   -15.665 17.094  1.000 18.854 0 302 BEN A C1  1 ? 
HETATM 1632 C  C2  . BEN C 3 .   ? 1.348   -16.187 15.946  1.000 19.458 0 302 BEN A C2  1 ? 
HETATM 1633 C  C3  . BEN C 3 .   ? 1.084   -15.378 14.861  1.000 19.895 0 302 BEN A C3  1 ? 
HETATM 1634 C  C4  . BEN C 3 .   ? 1.390   -14.046 14.893  1.000 20.445 0 302 BEN A C4  1 ? 
HETATM 1635 C  C5  . BEN C 3 .   ? 1.946   -13.520 16.012  1.000 22.277 0 302 BEN A C5  1 ? 
HETATM 1636 C  C6  . BEN C 3 .   ? 2.227   -14.313 17.115  1.000 20.621 0 302 BEN A C6  1 ? 
HETATM 1637 C  C   . BEN C 3 .   ? 2.215   -16.514 18.276  1.000 17.941 0 302 BEN A C   1 ? 
HETATM 1638 N  N1  . BEN C 3 .   ? 1.860   -17.721 18.366  1.000 16.299 0 302 BEN A N1  1 ? 
HETATM 1639 N  N2  . BEN C 3 .   ? 2.931   -15.950 19.241  1.000 16.047 0 302 BEN A N2  1 ? 
HETATM 1640 O  O   . HOH D 4 .   ? -10.750 -27.417 16.432  1.000 15.545 0 401 HOH A O   1 ? 
HETATM 1641 O  O   . HOH D 4 .   ? 1.756   -8.598  3.739   1.000 33.140 0 402 HOH A O   1 ? 
HETATM 1642 O  O   . HOH D 4 .   ? 4.837   -30.819 0.633   1.000 29.978 0 403 HOH A O   1 ? 
HETATM 1643 O  O   . HOH D 4 .   ? 10.464  -34.641 -1.509  1.000 52.354 0 404 HOH A O   1 ? 
HETATM 1644 O  O   . HOH D 4 .   ? -8.000  -34.254 16.236  1.000 31.215 0 405 HOH A O   1 ? 
HETATM 1645 O  O   . HOH D 4 .   ? -1.560  -35.315 17.240  1.000 39.793 0 406 HOH A O   1 ? 
HETATM 1646 O  O   . HOH D 4 .   ? 14.046  -29.426 4.737   1.000 26.559 0 407 HOH A O   1 ? 
HETATM 1647 O  O   . HOH D 4 .   ? -16.277 -26.436 -4.408  1.000 27.423 0 408 HOH A O   1 ? 
HETATM 1648 O  O   . HOH D 4 .   ? -9.055  -3.849  12.752  1.000 32.839 0 409 HOH A O   1 ? 
HETATM 1649 O  O   . HOH D 4 .   ? 11.496  -28.849 6.149   1.000 21.132 0 410 HOH A O   1 ? 
HETATM 1650 O  O   . HOH D 4 .   ? -7.554  -8.186  9.244   1.000 25.113 0 411 HOH A O   1 ? 
HETATM 1651 O  O   . HOH D 4 .   ? 9.214   -28.821 -3.946  1.000 25.737 0 412 HOH A O   1 ? 
HETATM 1652 O  O   . HOH D 4 .   ? -4.592  -23.577 8.086   1.000 18.048 0 413 HOH A O   1 ? 
HETATM 1653 O  O   . HOH D 4 .   ? 2.009   -9.933  18.985  1.000 35.709 0 414 HOH A O   1 ? 
HETATM 1654 O  O   . HOH D 4 .   ? -10.538 -32.121 4.328   1.000 36.075 0 415 HOH A O   1 ? 
HETATM 1655 O  O   . HOH D 4 .   ? 8.457   -13.098 2.984   1.000 34.234 0 416 HOH A O   1 ? 
HETATM 1656 O  O   . HOH D 4 .   ? -5.823  -35.158 25.916  1.000 27.541 0 417 HOH A O   1 ? 
HETATM 1657 O  O   . HOH D 4 .   ? -8.916  -0.893  14.985  1.000 19.748 0 418 HOH A O   1 ? 
HETATM 1658 O  O   . HOH D 4 .   ? -5.188  -14.877 -7.440  1.000 42.963 0 419 HOH A O   1 ? 
HETATM 1659 O  O   . HOH D 4 .   ? 11.335  -28.338 18.886  1.000 36.450 0 420 HOH A O   1 ? 
HETATM 1660 O  O   . HOH D 4 .   ? 3.507   -31.796 -6.947  1.000 30.374 0 421 HOH A O   1 ? 
HETATM 1661 O  O   . HOH D 4 .   ? 1.907   -13.046 10.624  1.000 37.357 0 422 HOH A O   1 ? 
HETATM 1662 O  O   . HOH D 4 .   ? -9.667  -11.049 21.327  1.000 25.587 0 423 HOH A O   1 ? 
HETATM 1663 O  O   . HOH D 4 .   ? 1.085   -29.046 10.644  1.000 15.149 0 424 HOH A O   1 ? 
HETATM 1664 O  O   . HOH D 4 .   ? -6.228  -36.081 7.435   1.000 33.676 0 425 HOH A O   1 ? 
HETATM 1665 O  O   . HOH D 4 .   ? -7.097  -33.467 -8.092  1.000 50.854 0 426 HOH A O   1 ? 
HETATM 1666 O  O   . HOH D 4 .   ? -12.078 -21.671 23.994  1.000 43.028 0 427 HOH A O   1 ? 
HETATM 1667 O  O   . HOH D 4 .   ? 20.805  -13.995 15.129  1.000 54.595 0 428 HOH A O   1 ? 
HETATM 1668 O  O   . HOH D 4 .   ? 1.518   -28.605 -0.175  1.000 21.300 0 429 HOH A O   1 ? 
HETATM 1669 O  O   . HOH D 4 .   ? 3.358   -7.812  8.642   1.000 43.750 0 430 HOH A O   1 ? 
HETATM 1670 O  O   . HOH D 4 .   ? -15.201 -10.417 18.954  1.000 33.621 0 431 HOH A O   1 ? 
HETATM 1671 O  O   . HOH D 4 .   ? 4.723   -28.302 1.951   1.000 25.961 0 432 HOH A O   1 ? 
HETATM 1672 O  O   . HOH D 4 .   ? -7.411  -13.505 -2.912  1.000 44.967 0 433 HOH A O   1 ? 
HETATM 1673 O  O   . HOH D 4 .   ? 8.336   -29.245 3.082   1.000 27.502 0 434 HOH A O   1 ? 
HETATM 1674 O  O   . HOH D 4 .   ? 6.035   -30.565 3.814   1.000 28.038 0 435 HOH A O   1 ? 
HETATM 1675 O  O   . HOH D 4 .   ? -8.565  -9.332  6.702   1.000 24.815 0 436 HOH A O   1 ? 
HETATM 1676 O  O   . HOH D 4 .   ? -7.880  -34.586 21.194  1.000 36.808 0 437 HOH A O   1 ? 
HETATM 1677 O  O   . HOH D 4 .   ? -1.365  -35.773 13.969  1.000 29.987 0 438 HOH A O   1 ? 
HETATM 1678 O  O   . HOH D 4 .   ? -1.728  -12.016 14.338  1.000 22.733 0 439 HOH A O   1 ? 
HETATM 1679 O  O   . HOH D 4 .   ? 3.044   -14.462 -6.934  1.000 37.088 0 440 HOH A O   1 ? 
HETATM 1680 O  O   . HOH D 4 .   ? 9.323   -14.051 28.248  1.000 39.174 0 441 HOH A O   1 ? 
HETATM 1681 O  O   . HOH D 4 .   ? -7.026  -23.481 25.222  1.000 18.258 0 442 HOH A O   1 ? 
HETATM 1682 O  O   . HOH D 4 .   ? 14.884  -21.844 -8.158  1.000 23.324 0 443 HOH A O   1 ? 
HETATM 1683 O  O   . HOH D 4 .   ? -18.869 -14.715 16.372  1.000 34.011 0 444 HOH A O   1 ? 
HETATM 1684 O  O   . HOH D 4 .   ? 10.090  -12.026 17.520  1.000 45.689 0 445 HOH A O   1 ? 
HETATM 1685 O  O   . HOH D 4 .   ? -1.297  -36.234 22.211  1.000 36.631 0 446 HOH A O   1 ? 
HETATM 1686 O  O   . HOH D 4 .   ? -8.578  -16.236 16.532  1.000 18.290 0 447 HOH A O   1 ? 
HETATM 1687 O  O   . HOH D 4 .   ? -12.306 -33.546 5.806   1.000 34.597 0 448 HOH A O   1 ? 
HETATM 1688 O  O   . HOH D 4 .   ? -16.010 -13.583 -1.596  1.000 28.288 0 449 HOH A O   1 ? 
HETATM 1689 O  O   . HOH D 4 .   ? -1.200  -9.807  26.182  1.000 44.299 0 450 HOH A O   1 ? 
HETATM 1690 O  O   . HOH D 4 .   ? 8.389   -11.714 21.219  1.000 30.856 0 451 HOH A O   1 ? 
HETATM 1691 O  O   . HOH D 4 .   ? -13.488 -7.317  10.729  1.000 20.968 0 452 HOH A O   1 ? 
HETATM 1692 O  O   . HOH D 4 .   ? 15.985  -24.216 -8.939  1.000 38.943 0 453 HOH A O   1 ? 
HETATM 1693 O  O   . HOH D 4 .   ? -0.781  -18.539 17.062  1.000 17.081 0 454 HOH A O   1 ? 
HETATM 1694 O  O   . HOH D 4 .   ? -18.853 -18.036 15.064  1.000 39.118 0 455 HOH A O   1 ? 
HETATM 1695 O  O   . HOH D 4 .   ? -6.627  -36.252 4.627   1.000 62.025 0 456 HOH A O   1 ? 
HETATM 1696 O  O   . HOH D 4 .   ? -3.165  -26.528 30.585  1.000 31.449 0 457 HOH A O   1 ? 
HETATM 1697 O  O   . HOH D 4 .   ? -10.233 -28.181 19.483  1.000 33.747 0 458 HOH A O   1 ? 
HETATM 1698 O  O   . HOH D 4 .   ? -3.292  -20.303 -11.726 1.000 31.054 0 459 HOH A O   1 ? 
HETATM 1699 O  O   . HOH D 4 .   ? -9.920  -33.458 -3.417  1.000 41.717 0 460 HOH A O   1 ? 
HETATM 1700 O  O   . HOH D 4 .   ? -2.473  -37.671 -2.307  1.000 55.656 0 461 HOH A O   1 ? 
HETATM 1701 O  O   . HOH D 4 .   ? -19.519 -20.058 -8.198  1.000 48.524 0 462 HOH A O   1 ? 
HETATM 1702 O  O   . HOH D 4 .   ? -19.500 -20.449 11.465  1.000 25.571 0 463 HOH A O   1 ? 
HETATM 1703 O  O   . HOH D 4 .   ? -12.553 -13.136 -3.946  1.000 35.188 0 464 HOH A O   1 ? 
HETATM 1704 O  O   . HOH D 4 .   ? -19.851 -23.518 11.375  1.000 23.481 0 465 HOH A O   1 ? 
HETATM 1705 O  O   . HOH D 4 .   ? -11.260 -17.245 16.177  1.000 14.546 0 466 HOH A O   1 ? 
HETATM 1706 O  O   . HOH D 4 .   ? -9.717  -27.682 -12.156 1.000 39.739 0 467 HOH A O   1 ? 
HETATM 1707 O  O   . HOH D 4 .   ? -8.787  -34.601 -1.252  1.000 44.313 0 468 HOH A O   1 ? 
HETATM 1708 O  O   . HOH D 4 .   ? -16.406 -31.913 20.205  1.000 32.275 0 469 HOH A O   1 ? 
HETATM 1709 O  O   . HOH D 4 .   ? -6.637  -8.331  5.713   1.000 42.067 0 470 HOH A O   1 ? 
HETATM 1710 O  O   . HOH D 4 .   ? -5.366  -6.561  -0.607  1.000 34.457 0 471 HOH A O   1 ? 
HETATM 1711 O  O   . HOH D 4 .   ? -4.817  -36.154 -0.435  1.000 33.414 0 472 HOH A O   1 ? 
HETATM 1712 O  O   . HOH D 4 .   ? -18.349 -20.121 15.512  1.000 47.698 0 473 HOH A O   1 ? 
HETATM 1713 O  O   . HOH D 4 .   ? 7.980   -11.474 14.251  1.000 46.446 0 474 HOH A O   1 ? 
HETATM 1714 O  O   . HOH D 4 .   ? -21.224 -16.791 13.053  1.000 43.392 0 475 HOH A O   1 ? 
HETATM 1715 O  O   . HOH D 4 .   ? -15.391 -27.840 22.649  1.000 43.567 0 476 HOH A O   1 ? 
HETATM 1716 O  O   . HOH D 4 .   ? -3.913  -8.129  9.499   1.000 43.934 0 477 HOH A O   1 ? 
HETATM 1717 O  O   . HOH D 4 .   ? -12.864 -35.152 22.342  1.000 60.402 0 478 HOH A O   1 ? 
HETATM 1718 O  O   . HOH D 4 .   ? -9.563  -11.949 -3.554  1.000 51.656 0 479 HOH A O   1 ? 
HETATM 1719 O  O   . HOH D 4 .   ? 4.150   -11.323 17.216  1.000 44.828 0 480 HOH A O   1 ? 
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