data_9AVM
# 
_entry.id   9AVM 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9AVM         pdb_00009avm 10.2210/pdb9avm/pdb 
WWPDB D_1000282119 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-03-12 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9AVM 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-04 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 1 
_pdbx_contact_author.email              clemke@broadinstitute.org 
_pdbx_contact_author.name_first         Christopher 
_pdbx_contact_author.name_last          Lemke 
_pdbx_contact_author.name_mi            T 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-9419-1511 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Raymond, D.D.' 1 0000-0003-4154-6141 
'Lemke, C.T.'   2 0000-0001-9419-1511 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To be published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Human genetics guides the discovery of novel CARD9 inhibitors with anti-inflammatory activity in vitro as well as in vivo' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
_citation_author.citation_id        primary 
_citation_author.name               'Raymond, D.D.' 
_citation_author.ordinal            1 
_citation_author.identifier_ORCID   0000-0003-4154-6141 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Caspase recruitment domain-containing protein 9' 7139.121 4   ? ? ? ? 
2 water   nat water                                             18.015   106 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        hCARD9 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       AKHQERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLK 
_entity_poly.pdbx_seq_one_letter_code_can   AKHQERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLK 
_entity_poly.pdbx_strand_id                 A,B,C,D 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1  ALA n 
1 2  LYS n 
1 3  HIS n 
1 4  GLN n 
1 5  GLU n 
1 6  ARG n 
1 7  VAL n 
1 8  GLN n 
1 9  ARG n 
1 10 LEU n 
1 11 LYS n 
1 12 GLU n 
1 13 GLU n 
1 14 CYS n 
1 15 GLU n 
1 16 ALA n 
1 17 GLY n 
1 18 SER n 
1 19 ARG n 
1 20 GLU n 
1 21 LEU n 
1 22 LYS n 
1 23 ARG n 
1 24 CYS n 
1 25 LYS n 
1 26 GLU n 
1 27 GLU n 
1 28 ASN n 
1 29 TYR n 
1 30 ASP n 
1 31 LEU n 
1 32 ALA n 
1 33 MET n 
1 34 ARG n 
1 35 LEU n 
1 36 ALA n 
1 37 HIS n 
1 38 GLN n 
1 39 SER n 
1 40 GLU n 
1 41 GLU n 
1 42 LYS n 
1 43 GLY n 
1 44 ALA n 
1 45 ALA n 
1 46 LEU n 
1 47 MET n 
1 48 ARG n 
1 49 ASN n 
1 50 ARG n 
1 51 ASP n 
1 52 LEU n 
1 53 GLN n 
1 54 LEU n 
1 55 GLU n 
1 56 ILE n 
1 57 ASP n 
1 58 GLN n 
1 59 LEU n 
1 60 LYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   60 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 CARD9 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1  ALA 1  155 ?   ?   ?   A . n 
A 1 2  LYS 2  156 ?   ?   ?   A . n 
A 1 3  HIS 3  157 ?   ?   ?   A . n 
A 1 4  GLN 4  158 ?   ?   ?   A . n 
A 1 5  GLU 5  159 ?   ?   ?   A . n 
A 1 6  ARG 6  160 ?   ?   ?   A . n 
A 1 7  VAL 7  161 ?   ?   ?   A . n 
A 1 8  GLN 8  162 ?   ?   ?   A . n 
A 1 9  ARG 9  163 163 ARG ARG A . n 
A 1 10 LEU 10 164 164 LEU LEU A . n 
A 1 11 LYS 11 165 165 LYS LYS A . n 
A 1 12 GLU 12 166 166 GLU GLU A . n 
A 1 13 GLU 13 167 167 GLU GLU A . n 
A 1 14 CYS 14 168 168 CYS CYS A . n 
A 1 15 GLU 15 169 169 GLU GLU A . n 
A 1 16 ALA 16 170 170 ALA ALA A . n 
A 1 17 GLY 17 171 171 GLY GLY A . n 
A 1 18 SER 18 172 172 SER SER A . n 
A 1 19 ARG 19 173 173 ARG ARG A . n 
A 1 20 GLU 20 174 174 GLU GLU A . n 
A 1 21 LEU 21 175 175 LEU LEU A . n 
A 1 22 LYS 22 176 176 LYS LYS A . n 
A 1 23 ARG 23 177 177 ARG ARG A . n 
A 1 24 CYS 24 178 178 CYS CYS A . n 
A 1 25 LYS 25 179 179 LYS LYS A . n 
A 1 26 GLU 26 180 180 GLU GLU A . n 
A 1 27 GLU 27 181 181 GLU GLU A . n 
A 1 28 ASN 28 182 182 ASN ASN A . n 
A 1 29 TYR 29 183 183 TYR TYR A . n 
A 1 30 ASP 30 184 184 ASP ASP A . n 
A 1 31 LEU 31 185 185 LEU LEU A . n 
A 1 32 ALA 32 186 186 ALA ALA A . n 
A 1 33 MET 33 187 187 MET MET A . n 
A 1 34 ARG 34 188 188 ARG ARG A . n 
A 1 35 LEU 35 189 189 LEU LEU A . n 
A 1 36 ALA 36 190 190 ALA ALA A . n 
A 1 37 HIS 37 191 191 HIS HIS A . n 
A 1 38 GLN 38 192 192 GLN GLN A . n 
A 1 39 SER 39 193 193 SER SER A . n 
A 1 40 GLU 40 194 194 GLU GLU A . n 
A 1 41 GLU 41 195 195 GLU GLU A . n 
A 1 42 LYS 42 196 196 LYS LYS A . n 
A 1 43 GLY 43 197 197 GLY GLY A . n 
A 1 44 ALA 44 198 198 ALA ALA A . n 
A 1 45 ALA 45 199 199 ALA ALA A . n 
A 1 46 LEU 46 200 200 LEU LEU A . n 
A 1 47 MET 47 201 201 MET MET A . n 
A 1 48 ARG 48 202 202 ARG ARG A . n 
A 1 49 ASN 49 203 203 ASN ASN A . n 
A 1 50 ARG 50 204 204 ARG ARG A . n 
A 1 51 ASP 51 205 205 ASP ASP A . n 
A 1 52 LEU 52 206 206 LEU LEU A . n 
A 1 53 GLN 53 207 207 GLN GLN A . n 
A 1 54 LEU 54 208 208 LEU LEU A . n 
A 1 55 GLU 55 209 209 GLU GLU A . n 
A 1 56 ILE 56 210 210 ILE ILE A . n 
A 1 57 ASP 57 211 211 ASP ASP A . n 
A 1 58 GLN 58 212 212 GLN GLN A . n 
A 1 59 LEU 59 213 213 LEU LEU A . n 
A 1 60 LYS 60 214 214 LYS LYS A . n 
B 1 1  ALA 1  155 ?   ?   ?   B . n 
B 1 2  LYS 2  156 ?   ?   ?   B . n 
B 1 3  HIS 3  157 ?   ?   ?   B . n 
B 1 4  GLN 4  158 ?   ?   ?   B . n 
B 1 5  GLU 5  159 ?   ?   ?   B . n 
B 1 6  ARG 6  160 160 ARG ARG B . n 
B 1 7  VAL 7  161 161 VAL VAL B . n 
B 1 8  GLN 8  162 162 GLN GLN B . n 
B 1 9  ARG 9  163 163 ARG ARG B . n 
B 1 10 LEU 10 164 164 LEU LEU B . n 
B 1 11 LYS 11 165 165 LYS LYS B . n 
B 1 12 GLU 12 166 166 GLU GLU B . n 
B 1 13 GLU 13 167 167 GLU GLU B . n 
B 1 14 CYS 14 168 168 CYS CYS B . n 
B 1 15 GLU 15 169 169 GLU GLU B . n 
B 1 16 ALA 16 170 170 ALA ALA B . n 
B 1 17 GLY 17 171 171 GLY GLY B . n 
B 1 18 SER 18 172 172 SER SER B . n 
B 1 19 ARG 19 173 173 ARG ARG B . n 
B 1 20 GLU 20 174 174 GLU GLU B . n 
B 1 21 LEU 21 175 175 LEU LEU B . n 
B 1 22 LYS 22 176 176 LYS LYS B . n 
B 1 23 ARG 23 177 177 ARG ARG B . n 
B 1 24 CYS 24 178 178 CYS CYS B . n 
B 1 25 LYS 25 179 179 LYS LYS B . n 
B 1 26 GLU 26 180 180 GLU GLU B . n 
B 1 27 GLU 27 181 181 GLU GLU B . n 
B 1 28 ASN 28 182 182 ASN ASN B . n 
B 1 29 TYR 29 183 183 TYR TYR B . n 
B 1 30 ASP 30 184 184 ASP ASP B . n 
B 1 31 LEU 31 185 185 LEU LEU B . n 
B 1 32 ALA 32 186 186 ALA ALA B . n 
B 1 33 MET 33 187 187 MET MET B . n 
B 1 34 ARG 34 188 188 ARG ARG B . n 
B 1 35 LEU 35 189 189 LEU LEU B . n 
B 1 36 ALA 36 190 190 ALA ALA B . n 
B 1 37 HIS 37 191 191 HIS HIS B . n 
B 1 38 GLN 38 192 192 GLN GLN B . n 
B 1 39 SER 39 193 193 SER SER B . n 
B 1 40 GLU 40 194 194 GLU GLU B . n 
B 1 41 GLU 41 195 195 GLU GLU B . n 
B 1 42 LYS 42 196 196 LYS LYS B . n 
B 1 43 GLY 43 197 197 GLY GLY B . n 
B 1 44 ALA 44 198 198 ALA ALA B . n 
B 1 45 ALA 45 199 199 ALA ALA B . n 
B 1 46 LEU 46 200 200 LEU LEU B . n 
B 1 47 MET 47 201 201 MET MET B . n 
B 1 48 ARG 48 202 202 ARG ARG B . n 
B 1 49 ASN 49 203 203 ASN ASN B . n 
B 1 50 ARG 50 204 204 ARG ARG B . n 
B 1 51 ASP 51 205 205 ASP ASP B . n 
B 1 52 LEU 52 206 206 LEU LEU B . n 
B 1 53 GLN 53 207 207 GLN GLN B . n 
B 1 54 LEU 54 208 208 LEU LEU B . n 
B 1 55 GLU 55 209 209 GLU GLU B . n 
B 1 56 ILE 56 210 210 ILE ILE B . n 
B 1 57 ASP 57 211 211 ASP ASP B . n 
B 1 58 GLN 58 212 212 GLN GLN B . n 
B 1 59 LEU 59 213 213 LEU LEU B . n 
B 1 60 LYS 60 214 214 LYS LYS B . n 
C 1 1  ALA 1  155 155 ALA ALA C . n 
C 1 2  LYS 2  156 156 LYS LYS C . n 
C 1 3  HIS 3  157 157 HIS HIS C . n 
C 1 4  GLN 4  158 158 GLN GLN C . n 
C 1 5  GLU 5  159 159 GLU GLU C . n 
C 1 6  ARG 6  160 160 ARG ARG C . n 
C 1 7  VAL 7  161 161 VAL VAL C . n 
C 1 8  GLN 8  162 162 GLN GLN C . n 
C 1 9  ARG 9  163 163 ARG ARG C . n 
C 1 10 LEU 10 164 164 LEU LEU C . n 
C 1 11 LYS 11 165 165 LYS LYS C . n 
C 1 12 GLU 12 166 166 GLU GLU C . n 
C 1 13 GLU 13 167 167 GLU GLU C . n 
C 1 14 CYS 14 168 168 CYS CYS C . n 
C 1 15 GLU 15 169 169 GLU GLU C . n 
C 1 16 ALA 16 170 170 ALA ALA C . n 
C 1 17 GLY 17 171 171 GLY GLY C . n 
C 1 18 SER 18 172 172 SER SER C . n 
C 1 19 ARG 19 173 173 ARG ARG C . n 
C 1 20 GLU 20 174 174 GLU GLU C . n 
C 1 21 LEU 21 175 175 LEU LEU C . n 
C 1 22 LYS 22 176 176 LYS LYS C . n 
C 1 23 ARG 23 177 177 ARG ARG C . n 
C 1 24 CYS 24 178 178 CYS CYS C . n 
C 1 25 LYS 25 179 179 LYS LYS C . n 
C 1 26 GLU 26 180 180 GLU GLU C . n 
C 1 27 GLU 27 181 181 GLU GLU C . n 
C 1 28 ASN 28 182 182 ASN ASN C . n 
C 1 29 TYR 29 183 183 TYR TYR C . n 
C 1 30 ASP 30 184 184 ASP ASP C . n 
C 1 31 LEU 31 185 185 LEU LEU C . n 
C 1 32 ALA 32 186 186 ALA ALA C . n 
C 1 33 MET 33 187 187 MET MET C . n 
C 1 34 ARG 34 188 188 ARG ARG C . n 
C 1 35 LEU 35 189 189 LEU LEU C . n 
C 1 36 ALA 36 190 190 ALA ALA C . n 
C 1 37 HIS 37 191 191 HIS HIS C . n 
C 1 38 GLN 38 192 192 GLN GLN C . n 
C 1 39 SER 39 193 193 SER SER C . n 
C 1 40 GLU 40 194 194 GLU GLU C . n 
C 1 41 GLU 41 195 195 GLU GLU C . n 
C 1 42 LYS 42 196 196 LYS LYS C . n 
C 1 43 GLY 43 197 197 GLY GLY C . n 
C 1 44 ALA 44 198 198 ALA ALA C . n 
C 1 45 ALA 45 199 199 ALA ALA C . n 
C 1 46 LEU 46 200 200 LEU LEU C . n 
C 1 47 MET 47 201 201 MET MET C . n 
C 1 48 ARG 48 202 202 ARG ARG C . n 
C 1 49 ASN 49 203 203 ASN ASN C . n 
C 1 50 ARG 50 204 204 ARG ARG C . n 
C 1 51 ASP 51 205 205 ASP ASP C . n 
C 1 52 LEU 52 206 206 LEU LEU C . n 
C 1 53 GLN 53 207 207 GLN GLN C . n 
C 1 54 LEU 54 208 208 LEU LEU C . n 
C 1 55 GLU 55 209 209 GLU GLU C . n 
C 1 56 ILE 56 210 210 ILE ILE C . n 
C 1 57 ASP 57 211 211 ASP ASP C . n 
C 1 58 GLN 58 212 212 GLN GLN C . n 
C 1 59 LEU 59 213 213 LEU LEU C . n 
C 1 60 LYS 60 214 214 LYS LYS C . n 
D 1 1  ALA 1  155 155 ALA ALA D . n 
D 1 2  LYS 2  156 156 LYS LYS D . n 
D 1 3  HIS 3  157 157 HIS HIS D . n 
D 1 4  GLN 4  158 158 GLN GLN D . n 
D 1 5  GLU 5  159 159 GLU GLU D . n 
D 1 6  ARG 6  160 160 ARG ARG D . n 
D 1 7  VAL 7  161 161 VAL VAL D . n 
D 1 8  GLN 8  162 162 GLN GLN D . n 
D 1 9  ARG 9  163 163 ARG ARG D . n 
D 1 10 LEU 10 164 164 LEU LEU D . n 
D 1 11 LYS 11 165 165 LYS LYS D . n 
D 1 12 GLU 12 166 166 GLU GLU D . n 
D 1 13 GLU 13 167 167 GLU GLU D . n 
D 1 14 CYS 14 168 168 CYS CYS D . n 
D 1 15 GLU 15 169 169 GLU ALA D . n 
D 1 16 ALA 16 170 170 ALA ALA D . n 
D 1 17 GLY 17 171 171 GLY GLY D . n 
D 1 18 SER 18 172 172 SER SER D . n 
D 1 19 ARG 19 173 173 ARG ARG D . n 
D 1 20 GLU 20 174 174 GLU GLU D . n 
D 1 21 LEU 21 175 175 LEU LEU D . n 
D 1 22 LYS 22 176 176 LYS LYS D . n 
D 1 23 ARG 23 177 177 ARG ARG D . n 
D 1 24 CYS 24 178 178 CYS CYS D . n 
D 1 25 LYS 25 179 179 LYS LYS D . n 
D 1 26 GLU 26 180 180 GLU GLU D . n 
D 1 27 GLU 27 181 181 GLU GLU D . n 
D 1 28 ASN 28 182 182 ASN ASN D . n 
D 1 29 TYR 29 183 183 TYR TYR D . n 
D 1 30 ASP 30 184 184 ASP ASP D . n 
D 1 31 LEU 31 185 185 LEU LEU D . n 
D 1 32 ALA 32 186 186 ALA ALA D . n 
D 1 33 MET 33 187 187 MET MET D . n 
D 1 34 ARG 34 188 188 ARG ARG D . n 
D 1 35 LEU 35 189 189 LEU LEU D . n 
D 1 36 ALA 36 190 190 ALA ALA D . n 
D 1 37 HIS 37 191 191 HIS HIS D . n 
D 1 38 GLN 38 192 192 GLN GLN D . n 
D 1 39 SER 39 193 193 SER SER D . n 
D 1 40 GLU 40 194 194 GLU GLU D . n 
D 1 41 GLU 41 195 195 GLU GLU D . n 
D 1 42 LYS 42 196 196 LYS LYS D . n 
D 1 43 GLY 43 197 197 GLY GLY D . n 
D 1 44 ALA 44 198 198 ALA ALA D . n 
D 1 45 ALA 45 199 199 ALA ALA D . n 
D 1 46 LEU 46 200 200 LEU LEU D . n 
D 1 47 MET 47 201 201 MET MET D . n 
D 1 48 ARG 48 202 202 ARG ARG D . n 
D 1 49 ASN 49 203 203 ASN ASN D . n 
D 1 50 ARG 50 204 204 ARG ARG D . n 
D 1 51 ASP 51 205 205 ASP ASP D . n 
D 1 52 LEU 52 206 206 LEU LEU D . n 
D 1 53 GLN 53 207 207 GLN GLN D . n 
D 1 54 LEU 54 208 208 LEU LEU D . n 
D 1 55 GLU 55 209 209 GLU GLU D . n 
D 1 56 ILE 56 210 210 ILE ILE D . n 
D 1 57 ASP 57 211 211 ASP ASP D . n 
D 1 58 GLN 58 212 212 GLN GLN D . n 
D 1 59 LEU 59 213 213 LEU LEU D . n 
D 1 60 LYS 60 214 214 LYS LYS D . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
E 2 HOH 1  301 88  HOH HOH A . 
E 2 HOH 2  302 32  HOH HOH A . 
E 2 HOH 3  303 48  HOH HOH A . 
E 2 HOH 4  304 42  HOH HOH A . 
E 2 HOH 5  305 47  HOH HOH A . 
E 2 HOH 6  306 9   HOH HOH A . 
E 2 HOH 7  307 15  HOH HOH A . 
E 2 HOH 8  308 76  HOH HOH A . 
E 2 HOH 9  309 31  HOH HOH A . 
E 2 HOH 10 310 96  HOH HOH A . 
E 2 HOH 11 311 58  HOH HOH A . 
E 2 HOH 12 312 35  HOH HOH A . 
E 2 HOH 13 313 25  HOH HOH A . 
E 2 HOH 14 314 22  HOH HOH A . 
E 2 HOH 15 315 55  HOH HOH A . 
E 2 HOH 16 316 61  HOH HOH A . 
E 2 HOH 17 317 106 HOH HOH A . 
E 2 HOH 18 318 93  HOH HOH A . 
E 2 HOH 19 319 67  HOH HOH A . 
E 2 HOH 20 320 90  HOH HOH A . 
E 2 HOH 21 321 77  HOH HOH A . 
E 2 HOH 22 322 45  HOH HOH A . 
E 2 HOH 23 323 91  HOH HOH A . 
F 2 HOH 1  301 69  HOH HOH B . 
F 2 HOH 2  302 44  HOH HOH B . 
F 2 HOH 3  303 51  HOH HOH B . 
F 2 HOH 4  304 1   HOH HOH B . 
F 2 HOH 5  305 16  HOH HOH B . 
F 2 HOH 6  306 6   HOH HOH B . 
F 2 HOH 7  307 66  HOH HOH B . 
F 2 HOH 8  308 102 HOH HOH B . 
F 2 HOH 9  309 23  HOH HOH B . 
F 2 HOH 10 310 18  HOH HOH B . 
F 2 HOH 11 311 50  HOH HOH B . 
F 2 HOH 12 312 86  HOH HOH B . 
F 2 HOH 13 313 84  HOH HOH B . 
F 2 HOH 14 314 95  HOH HOH B . 
F 2 HOH 15 315 65  HOH HOH B . 
F 2 HOH 16 316 39  HOH HOH B . 
G 2 HOH 1  301 73  HOH HOH C . 
G 2 HOH 2  302 29  HOH HOH C . 
G 2 HOH 3  303 38  HOH HOH C . 
G 2 HOH 4  304 7   HOH HOH C . 
G 2 HOH 5  305 75  HOH HOH C . 
G 2 HOH 6  306 80  HOH HOH C . 
G 2 HOH 7  307 13  HOH HOH C . 
G 2 HOH 8  308 46  HOH HOH C . 
G 2 HOH 9  309 26  HOH HOH C . 
G 2 HOH 10 310 12  HOH HOH C . 
G 2 HOH 11 311 53  HOH HOH C . 
G 2 HOH 12 312 2   HOH HOH C . 
G 2 HOH 13 313 54  HOH HOH C . 
G 2 HOH 14 314 41  HOH HOH C . 
G 2 HOH 15 315 20  HOH HOH C . 
G 2 HOH 16 316 19  HOH HOH C . 
G 2 HOH 17 317 34  HOH HOH C . 
G 2 HOH 18 318 105 HOH HOH C . 
G 2 HOH 19 319 14  HOH HOH C . 
G 2 HOH 20 320 40  HOH HOH C . 
G 2 HOH 21 321 64  HOH HOH C . 
G 2 HOH 22 322 72  HOH HOH C . 
G 2 HOH 23 323 57  HOH HOH C . 
G 2 HOH 24 324 10  HOH HOH C . 
G 2 HOH 25 325 24  HOH HOH C . 
G 2 HOH 26 326 8   HOH HOH C . 
G 2 HOH 27 327 56  HOH HOH C . 
G 2 HOH 28 328 17  HOH HOH C . 
G 2 HOH 29 329 60  HOH HOH C . 
G 2 HOH 30 330 28  HOH HOH C . 
G 2 HOH 31 331 74  HOH HOH C . 
G 2 HOH 32 332 98  HOH HOH C . 
G 2 HOH 33 333 101 HOH HOH C . 
G 2 HOH 34 334 63  HOH HOH C . 
G 2 HOH 35 335 21  HOH HOH C . 
G 2 HOH 36 336 43  HOH HOH C . 
H 2 HOH 1  301 103 HOH HOH D . 
H 2 HOH 2  302 5   HOH HOH D . 
H 2 HOH 3  303 3   HOH HOH D . 
H 2 HOH 4  304 82  HOH HOH D . 
H 2 HOH 5  305 68  HOH HOH D . 
H 2 HOH 6  306 104 HOH HOH D . 
H 2 HOH 7  307 11  HOH HOH D . 
H 2 HOH 8  308 52  HOH HOH D . 
H 2 HOH 9  309 71  HOH HOH D . 
H 2 HOH 10 310 36  HOH HOH D . 
H 2 HOH 11 311 89  HOH HOH D . 
H 2 HOH 12 312 78  HOH HOH D . 
H 2 HOH 13 313 4   HOH HOH D . 
H 2 HOH 14 314 33  HOH HOH D . 
H 2 HOH 15 315 70  HOH HOH D . 
H 2 HOH 16 316 81  HOH HOH D . 
H 2 HOH 17 317 49  HOH HOH D . 
H 2 HOH 18 318 30  HOH HOH D . 
H 2 HOH 19 319 87  HOH HOH D . 
H 2 HOH 20 320 62  HOH HOH D . 
H 2 HOH 21 321 92  HOH HOH D . 
H 2 HOH 22 322 94  HOH HOH D . 
H 2 HOH 23 323 99  HOH HOH D . 
H 2 HOH 24 324 79  HOH HOH D . 
H 2 HOH 25 325 27  HOH HOH D . 
H 2 HOH 26 326 37  HOH HOH D . 
H 2 HOH 27 327 97  HOH HOH D . 
H 2 HOH 28 328 83  HOH HOH D . 
H 2 HOH 29 329 85  HOH HOH D . 
H 2 HOH 30 330 100 HOH HOH D . 
H 2 HOH 31 331 59  HOH HOH D . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 D GLU 169 ? CG  ? D GLU 15 CG  
2 1 Y 1 D GLU 169 ? CD  ? D GLU 15 CD  
3 1 Y 1 D GLU 169 ? OE1 ? D GLU 15 OE1 
4 1 Y 1 D GLU 169 ? OE2 ? D GLU 15 OE2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? BUSTER ? ? ? '2.10.3 (20-MAY-2020)' 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XSCALE ? ? ? .                      2 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .                      3 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .                      4 
# 
_cell.angle_alpha                  71.41 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   79.27 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  77.05 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9AVM 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     27.330 
_cell.length_a_esd                 ? 
_cell.length_b                     48.830 
_cell.length_b_esd                 ? 
_cell.length_c                     55.630 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9AVM 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9AVM 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.39 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          48.64 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '8-14% PEG 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            298 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-03-20 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'APS BEAMLINE 17-ID' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID 
_diffrn_source.pdbx_synchrotron_site       APS 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9AVM 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.79 
_reflns.d_resolution_low                               26.43 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     23908 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           96.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                2.03 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          9.72 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.06 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.997 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.044000000000000004 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
loop_
_reflns_shell.d_res_high 
_reflns_shell.d_res_low 
_reflns_shell.meanI_over_sigI_all 
_reflns_shell.meanI_over_sigI_obs 
_reflns_shell.number_measured_all 
_reflns_shell.number_measured_obs 
_reflns_shell.number_possible 
_reflns_shell.number_unique_all 
_reflns_shell.number_unique_obs 
_reflns_shell.percent_possible_obs 
_reflns_shell.Rmerge_F_all 
_reflns_shell.Rmerge_F_obs 
_reflns_shell.meanI_over_sigI_gt 
_reflns_shell.meanI_over_uI_all 
_reflns_shell.meanI_over_uI_gt 
_reflns_shell.number_measured_gt 
_reflns_shell.number_unique_gt 
_reflns_shell.percent_possible_gt 
_reflns_shell.Rmerge_F_gt 
_reflns_shell.Rmerge_I_gt 
_reflns_shell.pdbx_redundancy 
_reflns_shell.pdbx_chi_squared 
_reflns_shell.pdbx_netI_over_sigmaI_all 
_reflns_shell.pdbx_netI_over_sigmaI_obs 
_reflns_shell.pdbx_Rrim_I_all 
_reflns_shell.pdbx_Rpim_I_all 
_reflns_shell.pdbx_rejects 
_reflns_shell.pdbx_ordinal 
_reflns_shell.pdbx_diffrn_id 
_reflns_shell.pdbx_CC_half 
_reflns_shell.pdbx_CC_star 
_reflns_shell.pdbx_R_split 
_reflns_shell.percent_possible_all 
_reflns_shell.Rmerge_I_all 
_reflns_shell.Rmerge_I_obs 
_reflns_shell.pdbx_Rsym_value 
_reflns_shell.pdbx_percent_possible_ellipsoidal 
_reflns_shell.pdbx_percent_possible_spherical 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous 
_reflns_shell.pdbx_percent_possible_spherical_anomalous 
_reflns_shell.pdbx_redundancy_anomalous 
_reflns_shell.pdbx_CC_half_anomalous 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous 
_reflns_shell.pdbx_percent_possible_anomalous 
1.79 1.9  ? ? ? ? ? ? 3878 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.7120000000000001 ? ? 1 1 0.701              ? ? ? ? 0.52  ? ? ? ? ? ? ? 
? ? 
1.90 2.03 ? ? ? ? ? ? 3600 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.467              ? ? 2 1 0.794              ? ? ? ? 0.34  ? ? ? ? ? ? ? 
? ? 
2.03 2.19 ? ? ? ? ? ? 3336 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.217              ? ? 3 1 0.9440000000000001 ? ? ? ? 0.158 ? ? ? ? ? ? ? 
? ? 
2.19 2.39 ? ? ? ? ? ? 3013 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.14               ? ? 4 1 0.971              ? ? ? ? 0.102 ? ? ? ? ? ? ? 
? ? 
2.39 2.67 ? ? ? ? ? ? 2885 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.083              ? ? 5 1 0.9890000000000001 ? ? ? ? 0.061 ? ? ? ? ? ? ? 
? ? 
2.67 3.08 ? ? ? ? ? ? 2513 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.061              ? ? 6 1 0.993              ? ? ? ? 0.045 ? ? ? ? ? ? ? 
? ? 
3.08 3.76 ? ? ? ? ? ? 2086 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.048              ? ? 7 1 0.9940000000000001 ? ? ? ? 0.035 ? ? ? ? ? ? ? 
? ? 
3.76 5.27 ? ? ? ? ? ? 1654 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.043              ? ? 8 1 0.996              ? ? ? ? 0.032 ? ? ? ? ? ? ? 
? ? 
5.27 26.4 ? ? ? ? ? ? 943  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 0.04               ? ? 9 1 0.997              ? ? ? ? 0.03  ? ? ? ? ? ? ? 
? ? 
# 
_refine.aniso_B[1][1]                            0.31300 
_refine.aniso_B[1][2]                            -1.43920 
_refine.aniso_B[1][3]                            0.61010 
_refine.aniso_B[2][2]                            2.12840 
_refine.aniso_B[2][3]                            8.14840 
_refine.aniso_B[3][3]                            -2.44140 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               41.36 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.930 
_refine.correlation_coeff_Fo_to_Fc_free          0.898 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9AVM 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.790 
_refine.ls_d_res_low                             26.43 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     23908 
_refine.ls_number_reflns_R_free                  1196 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    96.2 
_refine.ls_percent_reflns_R_free                 5.000 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2443 
_refine.ls_R_factor_R_free                       0.2923 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2418 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          0.000 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   0.152 
_refine.pdbx_overall_SU_R_free_Blow_DPI          0.150 
_refine.pdbx_overall_SU_R_Blow_DPI               0.152 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             0.153 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_analyze.entry_id                        9AVM 
_refine_analyze.pdbx_refine_id                  'X-RAY DIFFRACTION' 
_refine_analyze.Luzzati_coordinate_error_free   ? 
_refine_analyze.Luzzati_coordinate_error_obs    0.32 
_refine_analyze.Luzzati_d_res_low_free          ? 
_refine_analyze.Luzzati_d_res_low_obs           ? 
_refine_analyze.Luzzati_sigma_a_free            ? 
_refine_analyze.Luzzati_sigma_a_free_details    ? 
_refine_analyze.Luzzati_sigma_a_obs             ? 
_refine_analyze.Luzzati_sigma_a_obs_details     ? 
_refine_analyze.number_disordered_residues      ? 
_refine_analyze.occupancy_sum_hydrogen          ? 
_refine_analyze.occupancy_sum_non_hydrogen      ? 
_refine_analyze.RG_d_res_high                   ? 
_refine_analyze.RG_d_res_low                    ? 
_refine_analyze.RG_free                         ? 
_refine_analyze.RG_work                         ? 
_refine_analyze.RG_free_work_ratio              ? 
_refine_analyze.pdbx_Luzzati_d_res_high_obs     ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.790 
_refine_hist.d_res_low                        26.43 
_refine_hist.number_atoms_solvent             106 
_refine_hist.number_atoms_total               1971 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1865 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.008 ? 1871 ? t_bond_d                  2.00  HARMONIC     
'X-RAY DIFFRACTION' ? 0.82  ? 2473 ? t_angle_deg               2.00  HARMONIC     
'X-RAY DIFFRACTION' ? ?     ? 783  ? t_dihedral_angle_d        2.00  SINUSOIDAL   
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_incorr_chiral_ct        ?     ?            
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_pseud_angle             ?     ?            
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_trig_c_planes           ?     ?            
'X-RAY DIFFRACTION' ? ?     ? 334  ? t_gen_planes              5.00  HARMONIC     
'X-RAY DIFFRACTION' ? ?     ? 1871 ? t_it                      10.00 HARMONIC     
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_nbd                     ?     ?            
'X-RAY DIFFRACTION' ? 2.11  ? ?    ? t_omega_torsion           ?     ?            
'X-RAY DIFFRACTION' ? 18.01 ? ?    ? t_other_torsion           ?     ?            
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_improper_torsion        ?     ?            
'X-RAY DIFFRACTION' ? ?     ? 223  ? t_chiral_improper_torsion 5.00  SEMIHARMONIC 
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_sum_occupancies         ?     ?            
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_utility_distance        ?     ?            
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_utility_angle           ?     ?            
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_utility_torsion         ?     ?            
'X-RAY DIFFRACTION' ? ?     ? 1612 ? t_ideal_dist_contact      4.00  SEMIHARMONIC 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       1.79 
_refine_ls_shell.d_res_low                        1.80 
_refine_ls_shell.number_reflns_all                479 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             ? 
_refine_ls_shell.number_reflns_R_work             455 
_refine_ls_shell.percent_reflns_obs               92.15 
_refine_ls_shell.percent_reflns_R_free            5.01 
_refine_ls_shell.R_factor_all                     0.2665 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.2678 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   51 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.2391 
# 
_struct.entry_id                     9AVM 
_struct.title                        'Crystal Structure of CARD9 coiled-coil K156-K214' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9AVM 
_struct_keywords.text            'Adapter protein, immune system' 
_struct_keywords.pdbx_keywords   'IMMUNE SYSTEM' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 1 ? 
D N N 1 ? 
E N N 2 ? 
F N N 2 ? 
G N N 2 ? 
H N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    CARD9_HUMAN 
_struct_ref.pdbx_db_accession          Q9H257 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   KHQERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLK 
_struct_ref.pdbx_align_begin           156 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9AVM A 2 ? 60 ? Q9H257 156 ? 214 ? 156 214 
2 1 9AVM B 2 ? 60 ? Q9H257 156 ? 214 ? 156 214 
3 1 9AVM C 2 ? 60 ? Q9H257 156 ? 214 ? 156 214 
4 1 9AVM D 2 ? 60 ? Q9H257 156 ? 214 ? 156 214 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9AVM ALA A 1 ? UNP Q9H257 ? ? 'expression tag' 155 1 
2 9AVM ALA B 1 ? UNP Q9H257 ? ? 'expression tag' 155 2 
3 9AVM ALA C 1 ? UNP Q9H257 ? ? 'expression tag' 155 3 
4 9AVM ALA D 1 ? UNP Q9H257 ? ? 'expression tag' 155 4 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_and_software_defined_assembly PISA dimeric 2 
2 author_and_software_defined_assembly PISA dimeric 2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2390 ? 
1 MORE         -20  ? 
1 'SSA (A^2)'  8350 ? 
2 'ABSA (A^2)' 2720 ? 
2 MORE         -26  ? 
2 'SSA (A^2)'  9480 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,B,E,F 
2 1 C,D,G,H 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 ARG A 9 ? LYS A 60 ? ARG A 163 LYS A 214 1 ? 52 
HELX_P HELX_P2 AA2 VAL B 7 ? LYS B 60 ? VAL B 161 LYS B 214 1 ? 54 
HELX_P HELX_P3 AA3 LYS C 2 ? LYS C 60 ? LYS C 156 LYS C 214 1 ? 59 
HELX_P HELX_P4 AA4 LYS D 2 ? LYS D 60 ? LYS D 156 LYS D 214 1 ? 59 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 24 SG ? ? ? 1_555 B CYS 24 SG ? ? A CYS 178 B CYS 178 1_555 ? ? ? ? ? ? ? 2.851 ? ? 
disulf2 disulf ? ? C CYS 24 SG ? ? ? 1_555 D CYS 24 SG ? ? C CYS 178 D CYS 178 1_555 ? ? ? ? ? ? ? 2.818 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 24 ? CYS B 24 ? CYS A 178 ? 1_555 CYS B 178 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS C 24 ? CYS D 24 ? CYS C 178 ? 1_555 CYS D 178 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
_pdbx_entry_details.entry_id                   9AVM 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A ALA 155 ? A ALA 1 
2  1 Y 1 A LYS 156 ? A LYS 2 
3  1 Y 1 A HIS 157 ? A HIS 3 
4  1 Y 1 A GLN 158 ? A GLN 4 
5  1 Y 1 A GLU 159 ? A GLU 5 
6  1 Y 1 A ARG 160 ? A ARG 6 
7  1 Y 1 A VAL 161 ? A VAL 7 
8  1 Y 1 A GLN 162 ? A GLN 8 
9  1 Y 1 B ALA 155 ? B ALA 1 
10 1 Y 1 B LYS 156 ? B LYS 2 
11 1 Y 1 B HIS 157 ? B HIS 3 
12 1 Y 1 B GLN 158 ? B GLN 4 
13 1 Y 1 B GLU 159 ? B GLU 5 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
SER N    N N N 250 
SER CA   C N S 251 
SER C    C N N 252 
SER O    O N N 253 
SER CB   C N N 254 
SER OG   O N N 255 
SER OXT  O N N 256 
SER H    H N N 257 
SER H2   H N N 258 
SER HA   H N N 259 
SER HB2  H N N 260 
SER HB3  H N N 261 
SER HG   H N N 262 
SER HXT  H N N 263 
TYR N    N N N 264 
TYR CA   C N S 265 
TYR C    C N N 266 
TYR O    O N N 267 
TYR CB   C N N 268 
TYR CG   C Y N 269 
TYR CD1  C Y N 270 
TYR CD2  C Y N 271 
TYR CE1  C Y N 272 
TYR CE2  C Y N 273 
TYR CZ   C Y N 274 
TYR OH   O N N 275 
TYR OXT  O N N 276 
TYR H    H N N 277 
TYR H2   H N N 278 
TYR HA   H N N 279 
TYR HB2  H N N 280 
TYR HB3  H N N 281 
TYR HD1  H N N 282 
TYR HD2  H N N 283 
TYR HE1  H N N 284 
TYR HE2  H N N 285 
TYR HH   H N N 286 
TYR HXT  H N N 287 
VAL N    N N N 288 
VAL CA   C N S 289 
VAL C    C N N 290 
VAL O    O N N 291 
VAL CB   C N N 292 
VAL CG1  C N N 293 
VAL CG2  C N N 294 
VAL OXT  O N N 295 
VAL H    H N N 296 
VAL H2   H N N 297 
VAL HA   H N N 298 
VAL HB   H N N 299 
VAL HG11 H N N 300 
VAL HG12 H N N 301 
VAL HG13 H N N 302 
VAL HG21 H N N 303 
VAL HG22 H N N 304 
VAL HG23 H N N 305 
VAL HXT  H N N 306 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
SER N   CA   sing N N 237 
SER N   H    sing N N 238 
SER N   H2   sing N N 239 
SER CA  C    sing N N 240 
SER CA  CB   sing N N 241 
SER CA  HA   sing N N 242 
SER C   O    doub N N 243 
SER C   OXT  sing N N 244 
SER CB  OG   sing N N 245 
SER CB  HB2  sing N N 246 
SER CB  HB3  sing N N 247 
SER OG  HG   sing N N 248 
SER OXT HXT  sing N N 249 
TYR N   CA   sing N N 250 
TYR N   H    sing N N 251 
TYR N   H2   sing N N 252 
TYR CA  C    sing N N 253 
TYR CA  CB   sing N N 254 
TYR CA  HA   sing N N 255 
TYR C   O    doub N N 256 
TYR C   OXT  sing N N 257 
TYR CB  CG   sing N N 258 
TYR CB  HB2  sing N N 259 
TYR CB  HB3  sing N N 260 
TYR CG  CD1  doub Y N 261 
TYR CG  CD2  sing Y N 262 
TYR CD1 CE1  sing Y N 263 
TYR CD1 HD1  sing N N 264 
TYR CD2 CE2  doub Y N 265 
TYR CD2 HD2  sing N N 266 
TYR CE1 CZ   doub Y N 267 
TYR CE1 HE1  sing N N 268 
TYR CE2 CZ   sing Y N 269 
TYR CE2 HE2  sing N N 270 
TYR CZ  OH   sing N N 271 
TYR OH  HH   sing N N 272 
TYR OXT HXT  sing N N 273 
VAL N   CA   sing N N 274 
VAL N   H    sing N N 275 
VAL N   H2   sing N N 276 
VAL CA  C    sing N N 277 
VAL CA  CB   sing N N 278 
VAL CA  HA   sing N N 279 
VAL C   O    doub N N 280 
VAL C   OXT  sing N N 281 
VAL CB  CG1  sing N N 282 
VAL CB  CG2  sing N N 283 
VAL CB  HB   sing N N 284 
VAL CG1 HG11 sing N N 285 
VAL CG1 HG12 sing N N 286 
VAL CG1 HG13 sing N N 287 
VAL CG2 HG21 sing N N 288 
VAL CG2 HG22 sing N N 289 
VAL CG2 HG23 sing N N 290 
VAL OXT HXT  sing N N 291 
# 
_pdbx_audit_support.funding_organization   'Other private' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      Other 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          'An idealized helix was used for molecular replacement' 
# 
_atom_sites.entry_id                    9AVM 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.036590 
_atom_sites.fract_transf_matrix[1][2]   -0.008414 
_atom_sites.fract_transf_matrix[1][3]   -0.004700 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.021014 
_atom_sites.fract_transf_matrix[2][3]   -0.006352 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.019113 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ARG A 1 9  ? 15.399 -50.124 -8.143  1.00 67.67 ? 163 ARG A N   1 
ATOM   2    C CA  . ARG A 1 9  ? 15.766 -49.006 -9.009  1.00 68.08 ? 163 ARG A CA  1 
ATOM   3    C C   . ARG A 1 9  ? 14.678 -47.932 -8.964  1.00 67.79 ? 163 ARG A C   1 
ATOM   4    O O   . ARG A 1 9  ? 14.933 -46.807 -8.528  1.00 68.08 ? 163 ARG A O   1 
ATOM   5    C CB  . ARG A 1 9  ? 16.044 -49.484 -10.454 1.00 69.88 ? 163 ARG A CB  1 
ATOM   6    C CG  . ARG A 1 9  ? 16.299 -48.344 -11.439 1.00 73.39 ? 163 ARG A CG  1 
ATOM   7    C CD  . ARG A 1 9  ? 15.836 -48.684 -12.846 1.00 76.36 ? 163 ARG A CD  1 
ATOM   8    N NE  . ARG A 1 9  ? 16.579 -49.811 -13.410 1.00 79.04 ? 163 ARG A NE  1 
ATOM   9    C CZ  . ARG A 1 9  ? 16.385 -50.304 -14.630 1.00 81.16 ? 163 ARG A CZ  1 
ATOM   10   N NH1 . ARG A 1 9  ? 15.472 -49.769 -15.433 1.00 80.81 ? 163 ARG A NH1 1 
ATOM   11   N NH2 . ARG A 1 9  ? 17.110 -51.328 -15.061 1.00 81.06 ? 163 ARG A NH2 1 
ATOM   12   N N   . LEU A 1 10 ? 13.462 -48.283 -9.391  1.00 66.97 ? 164 LEU A N   1 
ATOM   13   C CA  . LEU A 1 10 ? 12.352 -47.345 -9.357  1.00 66.49 ? 164 LEU A CA  1 
ATOM   14   C C   . LEU A 1 10 ? 11.587 -47.427 -8.047  1.00 65.09 ? 164 LEU A C   1 
ATOM   15   O O   . LEU A 1 10 ? 11.051 -46.418 -7.622  1.00 65.50 ? 164 LEU A O   1 
ATOM   16   C CB  . LEU A 1 10 ? 11.447 -47.508 -10.578 1.00 67.07 ? 164 LEU A CB  1 
ATOM   17   C CG  . LEU A 1 10 ? 12.147 -47.190 -11.893 1.00 68.79 ? 164 LEU A CG  1 
ATOM   18   C CD1 . LEU A 1 10 ? 11.333 -47.656 -13.082 1.00 69.66 ? 164 LEU A CD1 1 
ATOM   19   C CD2 . LEU A 1 10 ? 12.495 -45.715 -11.988 1.00 69.40 ? 164 LEU A CD2 1 
ATOM   20   N N   . LYS A 1 11 ? 11.584 -48.593 -7.376  1.00 63.24 ? 165 LYS A N   1 
ATOM   21   C CA  . LYS A 1 11 ? 10.928 -48.765 -6.086  1.00 62.22 ? 165 LYS A CA  1 
ATOM   22   C C   . LYS A 1 11 ? 11.563 -47.833 -5.045  1.00 60.52 ? 165 LYS A C   1 
ATOM   23   O O   . LYS A 1 11 ? 10.839 -47.136 -4.333  1.00 60.65 ? 165 LYS A O   1 
ATOM   24   C CB  . LYS A 1 11 ? 11.020 -50.235 -5.632  1.00 64.21 ? 165 LYS A CB  1 
ATOM   25   C CG  . LYS A 1 11 ? 10.468 -50.491 -4.235  1.00 68.40 ? 165 LYS A CG  1 
ATOM   26   C CD  . LYS A 1 11 ? 10.460 -51.971 -3.919  1.00 72.56 ? 165 LYS A CD  1 
ATOM   27   C CE  . LYS A 1 11 ? 9.833  -52.247 -2.582  1.00 75.67 ? 165 LYS A CE  1 
ATOM   28   N NZ  . LYS A 1 11 ? 10.737 -51.926 -1.447  1.00 77.43 ? 165 LYS A NZ  1 
ATOM   29   N N   . GLU A 1 12 ? 12.911 -47.797 -4.987  1.00 58.50 ? 166 GLU A N   1 
ATOM   30   C CA  . GLU A 1 12 ? 13.646 -46.943 -4.052  1.00 56.97 ? 166 GLU A CA  1 
ATOM   31   C C   . GLU A 1 12 ? 13.454 -45.453 -4.342  1.00 54.54 ? 166 GLU A C   1 
ATOM   32   O O   . GLU A 1 12 ? 13.251 -44.686 -3.405  1.00 54.43 ? 166 GLU A O   1 
ATOM   33   C CB  . GLU A 1 12 ? 15.136 -47.320 -3.991  1.00 59.56 ? 166 GLU A CB  1 
ATOM   34   C CG  . GLU A 1 12 ? 15.796 -47.468 -5.353  1.00 64.42 ? 166 GLU A CG  1 
ATOM   35   C CD  . GLU A 1 12 ? 17.228 -47.961 -5.308  1.00 70.00 ? 166 GLU A CD  1 
ATOM   36   O OE1 . GLU A 1 12 ? 17.442 -49.121 -4.888  1.00 70.61 ? 166 GLU A OE1 1 
ATOM   37   O OE2 . GLU A 1 12 ? 18.135 -47.188 -5.693  1.00 71.93 ? 166 GLU A OE2 1 
ATOM   38   N N   . GLU A 1 13 ? 13.497 -45.047 -5.626  1.00 52.48 ? 167 GLU A N   1 
ATOM   39   C CA  . GLU A 1 13 ? 13.286 -43.650 -6.017  1.00 51.19 ? 167 GLU A CA  1 
ATOM   40   C C   . GLU A 1 13 ? 11.847 -43.208 -5.715  1.00 49.32 ? 167 GLU A C   1 
ATOM   41   O O   . GLU A 1 13 ? 11.617 -42.056 -5.352  1.00 49.00 ? 167 GLU A O   1 
ATOM   42   C CB  . GLU A 1 13 ? 13.606 -43.435 -7.506  1.00 53.87 ? 167 GLU A CB  1 
ATOM   43   C CG  . GLU A 1 13 ? 15.093 -43.358 -7.817  1.00 60.01 ? 167 GLU A CG  1 
ATOM   44   C CD  . GLU A 1 13 ? 15.437 -42.989 -9.249  1.00 67.89 ? 167 GLU A CD  1 
ATOM   45   O OE1 . GLU A 1 13 ? 16.639 -42.787 -9.539  1.00 69.27 ? 167 GLU A OE1 1 
ATOM   46   O OE2 . GLU A 1 13 ? 14.508 -42.900 -10.084 1.00 70.38 ? 167 GLU A OE2 1 
ATOM   47   N N   . CYS A 1 14 ? 10.888 -44.129 -5.834  1.00 47.99 ? 168 CYS A N   1 
ATOM   48   C CA  . CYS A 1 14 ? 9.497  -43.834 -5.566  1.00 47.72 ? 168 CYS A CA  1 
ATOM   49   C C   . CYS A 1 14 ? 9.198  -43.766 -4.062  1.00 45.45 ? 168 CYS A C   1 
ATOM   50   O O   . CYS A 1 14 ? 8.361  -42.974 -3.653  1.00 44.77 ? 168 CYS A O   1 
ATOM   51   C CB  . CYS A 1 14 ? 8.600  -44.823 -6.292  1.00 50.38 ? 168 CYS A CB  1 
ATOM   52   S SG  . CYS A 1 14 ? 8.866  -44.871 -8.089  1.00 59.05 ? 168 CYS A SG  1 
ATOM   53   N N   . GLU A 1 15 ? 9.909  -44.543 -3.243  1.00 44.00 ? 169 GLU A N   1 
ATOM   54   C CA  . GLU A 1 15 ? 9.769  -44.463 -1.785  1.00 43.81 ? 169 GLU A CA  1 
ATOM   55   C C   . GLU A 1 15 ? 10.350 -43.126 -1.296  1.00 42.30 ? 169 GLU A C   1 
ATOM   56   O O   . GLU A 1 15 ? 9.787  -42.509 -0.393  1.00 42.31 ? 169 GLU A O   1 
ATOM   57   C CB  . GLU A 1 15 ? 10.518 -45.623 -1.096  1.00 46.81 ? 169 GLU A CB  1 
ATOM   58   C CG  . GLU A 1 15 ? 9.775  -46.938 -1.166  1.00 54.59 ? 169 GLU A CG  1 
ATOM   59   C CD  . GLU A 1 15 ? 10.607 -48.175 -0.894  1.00 63.09 ? 169 GLU A CD  1 
ATOM   60   O OE1 . GLU A 1 15 ? 11.845 -48.049 -0.739  1.00 64.88 ? 169 GLU A OE1 1 
ATOM   61   O OE2 . GLU A 1 15 ? 10.013 -49.277 -0.852  1.00 65.74 ? 169 GLU A OE2 1 
ATOM   62   N N   . ALA A 1 16 ? 11.487 -42.699 -1.896  1.00 40.96 ? 170 ALA A N   1 
ATOM   63   C CA  . ALA A 1 16 ? 12.170 -41.452 -1.569  1.00 40.37 ? 170 ALA A CA  1 
ATOM   64   C C   . ALA A 1 16 ? 11.293 -40.259 -1.966  1.00 39.63 ? 170 ALA A C   1 
ATOM   65   O O   . ALA A 1 16 ? 11.172 -39.306 -1.193  1.00 39.09 ? 170 ALA A O   1 
ATOM   66   C CB  . ALA A 1 16 ? 13.516 -41.382 -2.283  1.00 40.71 ? 170 ALA A CB  1 
ATOM   67   N N   . GLY A 1 17 ? 10.655 -40.350 -3.136  1.00 38.97 ? 171 GLY A N   1 
ATOM   68   C CA  . GLY A 1 17 ? 9.734  -39.331 -3.621  1.00 38.56 ? 171 GLY A CA  1 
ATOM   69   C C   . GLY A 1 17 ? 8.518  -39.158 -2.728  1.00 38.10 ? 171 GLY A C   1 
ATOM   70   O O   . GLY A 1 17 ? 8.105  -38.025 -2.472  1.00 37.82 ? 171 GLY A O   1 
ATOM   71   N N   . SER A 1 18 ? 7.939  -40.261 -2.203  1.00 37.51 ? 172 SER A N   1 
ATOM   72   C CA  . SER A 1 18 ? 6.768  -40.151 -1.320  1.00 37.32 ? 172 SER A CA  1 
ATOM   73   C C   . SER A 1 18 ? 7.146  -39.543 0.056   1.00 36.08 ? 172 SER A C   1 
ATOM   74   O O   . SER A 1 18 ? 6.347  -38.828 0.663   1.00 35.39 ? 172 SER A O   1 
ATOM   75   C CB  . SER A 1 18 ? 6.042  -41.494 -1.203  1.00 39.87 ? 172 SER A CB  1 
ATOM   76   O OG  . SER A 1 18 ? 6.419  -42.267 -0.075  1.00 43.46 ? 172 SER A OG  1 
ATOM   77   N N   . ARG A 1 19 ? 8.393  -39.774 0.505   1.00 34.87 ? 173 ARG A N   1 
ATOM   78   C CA  . ARG A 1 19 ? 8.873  -39.157 1.738   1.00 34.58 ? 173 ARG A CA  1 
ATOM   79   C C   . ARG A 1 19 ? 9.122  -37.654 1.503   1.00 33.50 ? 173 ARG A C   1 
ATOM   80   O O   . ARG A 1 19 ? 8.752  -36.832 2.337   1.00 33.70 ? 173 ARG A O   1 
ATOM   81   C CB  . ARG A 1 19 ? 10.139 -39.860 2.246   1.00 36.35 ? 173 ARG A CB  1 
ATOM   82   C CG  . ARG A 1 19 ? 9.831  -41.234 2.840   1.00 41.10 ? 173 ARG A CG  1 
ATOM   83   C CD  . ARG A 1 19 ? 11.037 -41.839 3.539   1.00 46.48 ? 173 ARG A CD  1 
ATOM   84   N NE  . ARG A 1 19 ? 11.816 -42.708 2.657   1.00 51.22 ? 173 ARG A NE  1 
ATOM   85   C CZ  . ARG A 1 19 ? 12.912 -42.335 2.007   1.00 53.27 ? 173 ARG A CZ  1 
ATOM   86   N NH1 . ARG A 1 19 ? 13.392 -41.105 2.151   1.00 52.91 ? 173 ARG A NH1 1 
ATOM   87   N NH2 . ARG A 1 19 ? 13.550 -43.194 1.225   1.00 53.16 ? 173 ARG A NH2 1 
ATOM   88   N N   . GLU A 1 20 ? 9.672  -37.299 0.344   1.00 32.27 ? 174 GLU A N   1 
ATOM   89   C CA  . GLU A 1 20 ? 9.896  -35.906 -0.019  1.00 31.63 ? 174 GLU A CA  1 
ATOM   90   C C   . GLU A 1 20 ? 8.561  -35.163 -0.204  1.00 30.87 ? 174 GLU A C   1 
ATOM   91   O O   . GLU A 1 20 ? 8.471  -33.985 0.158   1.00 30.97 ? 174 GLU A O   1 
ATOM   92   C CB  . GLU A 1 20 ? 10.749 -35.787 -1.282  1.00 33.75 ? 174 GLU A CB  1 
ATOM   93   C CG  . GLU A 1 20 ? 11.171 -34.358 -1.561  1.00 42.77 ? 174 GLU A CG  1 
ATOM   94   C CD  . GLU A 1 20 ? 12.310 -34.161 -2.538  1.00 53.54 ? 174 GLU A CD  1 
ATOM   95   O OE1 . GLU A 1 20 ? 12.530 -35.062 -3.383  1.00 57.50 ? 174 GLU A OE1 1 
ATOM   96   O OE2 . GLU A 1 20 ? 12.984 -33.107 -2.455  1.00 55.62 ? 174 GLU A OE2 1 
ATOM   97   N N   . LEU A 1 21 ? 7.531  -35.843 -0.718  1.00 30.07 ? 175 LEU A N   1 
ATOM   98   C CA  . LEU A 1 21 ? 6.207  -35.230 -0.893  1.00 31.10 ? 175 LEU A CA  1 
ATOM   99   C C   . LEU A 1 21 ? 5.592  -34.901 0.479   1.00 31.23 ? 175 LEU A C   1 
ATOM   100  O O   . LEU A 1 21 ? 5.057  -33.797 0.676   1.00 30.63 ? 175 LEU A O   1 
ATOM   101  C CB  . LEU A 1 21 ? 5.281  -36.141 -1.687  1.00 32.29 ? 175 LEU A CB  1 
ATOM   102  C CG  . LEU A 1 21 ? 3.837  -35.636 -1.872  1.00 34.73 ? 175 LEU A CG  1 
ATOM   103  C CD1 . LEU A 1 21 ? 3.792  -34.274 -2.623  1.00 35.27 ? 175 LEU A CD1 1 
ATOM   104  C CD2 . LEU A 1 21 ? 3.001  -36.663 -2.578  1.00 35.39 ? 175 LEU A CD2 1 
ATOM   105  N N   . LYS A 1 22 ? 5.727  -35.828 1.445   1.00 31.25 ? 176 LYS A N   1 
ATOM   106  C CA  . LYS A 1 22 ? 5.246  -35.615 2.824   1.00 31.54 ? 176 LYS A CA  1 
ATOM   107  C C   . LYS A 1 22 ? 5.919  -34.354 3.437   1.00 31.44 ? 176 LYS A C   1 
ATOM   108  O O   . LYS A 1 22 ? 5.244  -33.517 4.038   1.00 31.33 ? 176 LYS A O   1 
ATOM   109  C CB  . LYS A 1 22 ? 5.543  -36.873 3.679   1.00 34.14 ? 176 LYS A CB  1 
ATOM   110  C CG  . LYS A 1 22 ? 5.359  -36.660 5.189   1.00 38.75 ? 176 LYS A CG  1 
ATOM   111  C CD  . LYS A 1 22 ? 5.454  -37.943 5.983   1.00 42.76 ? 176 LYS A CD  1 
ATOM   112  C CE  . LYS A 1 22 ? 5.013  -37.721 7.409   1.00 45.00 ? 176 LYS A CE  1 
ATOM   113  N NZ  . LYS A 1 22 ? 6.044  -36.998 8.170   1.00 47.28 ? 176 LYS A NZ  1 
ATOM   114  N N   . ARG A 1 23 ? 7.242  -34.225 3.293   1.00 30.94 ? 177 ARG A N   1 
ATOM   115  C CA  . ARG A 1 23 ? 7.955  -33.049 3.791   1.00 30.08 ? 177 ARG A CA  1 
ATOM   116  C C   . ARG A 1 23 ? 7.525  -31.749 3.053   1.00 28.22 ? 177 ARG A C   1 
ATOM   117  O O   . ARG A 1 23 ? 7.378  -30.684 3.685   1.00 27.59 ? 177 ARG A O   1 
ATOM   118  C CB  . ARG A 1 23 ? 9.479  -33.242 3.717   1.00 33.71 ? 177 ARG A CB  1 
ATOM   119  C CG  . ARG A 1 23 ? 10.226 -32.127 4.482   1.00 41.91 ? 177 ARG A CG  1 
ATOM   120  C CD  . ARG A 1 23 ? 11.755 -32.219 4.450   1.00 47.71 ? 177 ARG A CD  1 
ATOM   121  N NE  . ARG A 1 23 ? 12.287 -32.529 3.121   1.00 53.41 ? 177 ARG A NE  1 
ATOM   122  C CZ  . ARG A 1 23 ? 12.421 -31.649 2.136   1.00 58.22 ? 177 ARG A CZ  1 
ATOM   123  N NH1 . ARG A 1 23 ? 12.062 -30.382 2.314   1.00 58.78 ? 177 ARG A NH1 1 
ATOM   124  N NH2 . ARG A 1 23 ? 12.921 -32.026 0.966   1.00 59.35 ? 177 ARG A NH2 1 
ATOM   125  N N   . CYS A 1 24 ? 7.326  -31.830 1.730   1.00 26.01 ? 178 CYS A N   1 
ATOM   126  C CA  . CYS A 1 24 ? 6.937  -30.663 0.950   1.00 26.12 ? 178 CYS A CA  1 
ATOM   127  C C   . CYS A 1 24 ? 5.556  -30.145 1.373   1.00 26.07 ? 178 CYS A C   1 
ATOM   128  O O   . CYS A 1 24 ? 5.353  -28.938 1.481   1.00 26.11 ? 178 CYS A O   1 
ATOM   129  C CB  . CYS A 1 24 ? 6.974  -31.000 -0.537  1.00 27.75 ? 178 CYS A CB  1 
ATOM   130  S SG  . CYS A 1 24 ? 6.985  -29.559 -1.621  1.00 32.55 ? 178 CYS A SG  1 
ATOM   131  N N   . LYS A 1 25 ? 4.618  -31.056 1.655   1.00 26.33 ? 179 LYS A N   1 
ATOM   132  C CA  . LYS A 1 25 ? 3.274  -30.665 2.093   1.00 27.03 ? 179 LYS A CA  1 
ATOM   133  C C   . LYS A 1 25 ? 3.305  -29.998 3.489   1.00 26.90 ? 179 LYS A C   1 
ATOM   134  O O   . LYS A 1 25 ? 2.589  -29.015 3.736   1.00 26.20 ? 179 LYS A O   1 
ATOM   135  C CB  . LYS A 1 25 ? 2.343  -31.872 2.072   1.00 29.15 ? 179 LYS A CB  1 
ATOM   136  C CG  . LYS A 1 25 ? 1.953  -32.297 0.659   1.00 33.60 ? 179 LYS A CG  1 
ATOM   137  C CD  . LYS A 1 25 ? 1.026  -33.489 0.762   1.00 41.35 ? 179 LYS A CD  1 
ATOM   138  C CE  . LYS A 1 25 ? 0.450  -33.919 -0.557  1.00 48.02 ? 179 LYS A CE  1 
ATOM   139  N NZ  . LYS A 1 25 ? -0.267 -35.215 -0.413  1.00 52.15 ? 179 LYS A NZ  1 
ATOM   140  N N   . GLU A 1 26 ? 4.179  -30.508 4.380   1.00 27.03 ? 180 GLU A N   1 
ATOM   141  C CA  . GLU A 1 26 ? 4.382  -29.910 5.709   1.00 28.24 ? 180 GLU A CA  1 
ATOM   142  C C   . GLU A 1 26 ? 4.951  -28.507 5.576   1.00 27.59 ? 180 GLU A C   1 
ATOM   143  O O   . GLU A 1 26 ? 4.487  -27.598 6.261   1.00 28.33 ? 180 GLU A O   1 
ATOM   144  C CB  . GLU A 1 26 ? 5.329  -30.777 6.559   1.00 30.82 ? 180 GLU A CB  1 
ATOM   145  C CG  . GLU A 1 26 ? 4.678  -32.066 7.034   1.00 37.39 ? 180 GLU A CG  1 
ATOM   146  C CD  . GLU A 1 26 ? 5.633  -33.107 7.586   1.00 46.01 ? 180 GLU A CD  1 
ATOM   147  O OE1 . GLU A 1 26 ? 6.867  -32.923 7.462   1.00 48.42 ? 180 GLU A OE1 1 
ATOM   148  O OE2 . GLU A 1 26 ? 5.142  -34.117 8.135   1.00 50.32 ? 180 GLU A OE2 1 
ATOM   149  N N   . GLU A 1 27 ? 5.933  -28.326 4.663   1.00 26.10 ? 181 GLU A N   1 
ATOM   150  C CA  . GLU A 1 27 ? 6.533  -27.034 4.387   1.00 25.69 ? 181 GLU A CA  1 
ATOM   151  C C   . GLU A 1 27 ? 5.523  -26.082 3.788   1.00 24.66 ? 181 GLU A C   1 
ATOM   152  O O   . GLU A 1 27 ? 5.588  -24.902 4.091   1.00 25.29 ? 181 GLU A O   1 
ATOM   153  C CB  . GLU A 1 27 ? 7.696  -27.136 3.417   1.00 28.43 ? 181 GLU A CB  1 
ATOM   154  C CG  . GLU A 1 27 ? 8.977  -27.626 4.014   1.00 37.42 ? 181 GLU A CG  1 
ATOM   155  C CD  . GLU A 1 27 ? 10.038 -27.179 3.035   1.00 45.12 ? 181 GLU A CD  1 
ATOM   156  O OE1 . GLU A 1 27 ? 10.166 -27.812 1.967   1.00 41.54 ? 181 GLU A OE1 1 
ATOM   157  O OE2 . GLU A 1 27 ? 10.652 -26.118 3.288   1.00 50.93 ? 181 GLU A OE2 1 
ATOM   158  N N   . ASN A 1 28 ? 4.608  -26.562 2.946   1.00 24.04 ? 182 ASN A N   1 
ATOM   159  C CA  . ASN A 1 28 ? 3.589  -25.716 2.330   1.00 25.05 ? 182 ASN A CA  1 
ATOM   160  C C   . ASN A 1 28 ? 2.671  -25.122 3.403   1.00 25.21 ? 182 ASN A C   1 
ATOM   161  O O   . ASN A 1 28 ? 2.378  -23.924 3.355   1.00 25.11 ? 182 ASN A O   1 
ATOM   162  C CB  . ASN A 1 28 ? 2.779  -26.501 1.267   1.00 27.07 ? 182 ASN A CB  1 
ATOM   163  C CG  . ASN A 1 28 ? 1.750  -25.636 0.560   1.00 30.25 ? 182 ASN A CG  1 
ATOM   164  O OD1 . ASN A 1 28 ? 2.028  -24.953 -0.446  1.00 31.37 ? 182 ASN A OD1 1 
ATOM   165  N ND2 . ASN A 1 28 ? 0.538  -25.640 1.079   1.00 29.70 ? 182 ASN A ND2 1 
ATOM   166  N N   . TYR A 1 29 ? 2.265  -25.940 4.383   1.00 24.34 ? 183 TYR A N   1 
ATOM   167  C CA  . TYR A 1 29 ? 1.399  -25.459 5.457   1.00 24.81 ? 183 TYR A CA  1 
ATOM   168  C C   . TYR A 1 29 ? 2.132  -24.416 6.313   1.00 23.62 ? 183 TYR A C   1 
ATOM   169  O O   . TYR A 1 29 ? 1.565  -23.372 6.658   1.00 23.21 ? 183 TYR A O   1 
ATOM   170  C CB  . TYR A 1 29 ? 0.867  -26.617 6.323   1.00 26.43 ? 183 TYR A CB  1 
ATOM   171  C CG  . TYR A 1 29 ? -0.195 -26.153 7.329   1.00 28.93 ? 183 TYR A CG  1 
ATOM   172  C CD1 . TYR A 1 29 ? -1.488 -25.842 6.921   1.00 31.05 ? 183 TYR A CD1 1 
ATOM   173  C CD2 . TYR A 1 29 ? 0.122  -25.959 8.662   1.00 30.57 ? 183 TYR A CD2 1 
ATOM   174  C CE1 . TYR A 1 29 ? -2.458 -25.413 7.837   1.00 32.92 ? 183 TYR A CE1 1 
ATOM   175  C CE2 . TYR A 1 29 ? -0.837 -25.545 9.589   1.00 32.68 ? 183 TYR A CE2 1 
ATOM   176  C CZ  . TYR A 1 29 ? -2.131 -25.285 9.177   1.00 34.12 ? 183 TYR A CZ  1 
ATOM   177  O OH  . TYR A 1 29 ? -3.051 -24.812 10.097  1.00 36.41 ? 183 TYR A OH  1 
ATOM   178  N N   . ASP A 1 30 ? 3.409  -24.678 6.601   1.00 22.65 ? 184 ASP A N   1 
ATOM   179  C CA  . ASP A 1 30 ? 4.245  -23.787 7.395   1.00 24.03 ? 184 ASP A CA  1 
ATOM   180  C C   . ASP A 1 30 ? 4.416  -22.446 6.677   1.00 23.72 ? 184 ASP A C   1 
ATOM   181  O O   . ASP A 1 30 ? 4.246  -21.401 7.318   1.00 22.46 ? 184 ASP A O   1 
ATOM   182  C CB  . ASP A 1 30 ? 5.615  -24.440 7.671   1.00 25.43 ? 184 ASP A CB  1 
ATOM   183  C CG  . ASP A 1 30 ? 6.595  -23.572 8.441   1.00 27.69 ? 184 ASP A CG  1 
ATOM   184  O OD1 . ASP A 1 30 ? 6.303  -23.236 9.604   1.00 28.25 ? 184 ASP A OD1 1 
ATOM   185  O OD2 . ASP A 1 30 ? 7.675  -23.274 7.894   1.00 28.30 ? 184 ASP A OD2 1 
ATOM   186  N N   . LEU A 1 31 ? 4.689  -22.476 5.357   1.00 23.22 ? 185 LEU A N   1 
ATOM   187  C CA  . LEU A 1 31 ? 4.844  -21.254 4.559   1.00 22.62 ? 185 LEU A CA  1 
ATOM   188  C C   . LEU A 1 31 ? 3.547  -20.449 4.553   1.00 22.26 ? 185 LEU A C   1 
ATOM   189  O O   . LEU A 1 31 ? 3.584  -19.231 4.695   1.00 21.63 ? 185 LEU A O   1 
ATOM   190  C CB  . LEU A 1 31 ? 5.291  -21.570 3.130   1.00 22.11 ? 185 LEU A CB  1 
ATOM   191  C CG  . LEU A 1 31 ? 6.773  -21.944 3.000   1.00 21.94 ? 185 LEU A CG  1 
ATOM   192  C CD1 . LEU A 1 31 ? 7.060  -22.526 1.628   1.00 23.21 ? 185 LEU A CD1 1 
ATOM   193  C CD2 . LEU A 1 31 ? 7.671  -20.712 3.248   1.00 21.30 ? 185 LEU A CD2 1 
ATOM   194  N N   . ALA A 1 32 ? 2.406  -21.117 4.382   1.00 21.95 ? 186 ALA A N   1 
ATOM   195  C CA  . ALA A 1 32 ? 1.116  -20.427 4.375   1.00 22.65 ? 186 ALA A CA  1 
ATOM   196  C C   . ALA A 1 32 ? 0.859  -19.707 5.690   1.00 21.64 ? 186 ALA A C   1 
ATOM   197  O O   . ALA A 1 32 ? 0.390  -18.573 5.668   1.00 22.38 ? 186 ALA A O   1 
ATOM   198  C CB  . ALA A 1 32 ? -0.017 -21.423 4.083   1.00 23.32 ? 186 ALA A CB  1 
ATOM   199  N N   . MET A 1 33 ? 1.165  -20.346 6.833   1.00 21.27 ? 187 MET A N   1 
ATOM   200  C CA  . MET A 1 33 ? 0.951  -19.726 8.154   1.00 21.28 ? 187 MET A CA  1 
ATOM   201  C C   . MET A 1 33 ? 1.888  -18.529 8.364   1.00 21.38 ? 187 MET A C   1 
ATOM   202  O O   . MET A 1 33 ? 1.465  -17.504 8.897   1.00 21.48 ? 187 MET A O   1 
ATOM   203  C CB  . MET A 1 33 ? 1.153  -20.740 9.292   1.00 21.94 ? 187 MET A CB  1 
ATOM   204  C CG  . MET A 1 33 ? 0.147  -21.851 9.277   1.00 25.49 ? 187 MET A CG  1 
ATOM   205  S SD  . MET A 1 33 ? -1.564 -21.297 9.448   1.00 34.02 ? 187 MET A SD  1 
ATOM   206  C CE  . MET A 1 33 ? -2.158 -21.505 7.819   1.00 35.69 ? 187 MET A CE  1 
ATOM   207  N N   . ARG A 1 34 ? 3.147  -18.670 7.931   1.00 20.93 ? 188 ARG A N   1 
ATOM   208  C CA  . ARG A 1 34 ? 4.138  -17.603 8.056   1.00 20.36 ? 188 ARG A CA  1 
ATOM   209  C C   . ARG A 1 34 ? 3.742  -16.418 7.175   1.00 20.88 ? 188 ARG A C   1 
ATOM   210  O O   . ARG A 1 34 ? 3.874  -15.271 7.613   1.00 21.82 ? 188 ARG A O   1 
ATOM   211  C CB  . ARG A 1 34 ? 5.526  -18.164 7.696   1.00 20.88 ? 188 ARG A CB  1 
ATOM   212  C CG  . ARG A 1 34 ? 6.061  -19.058 8.797   1.00 23.22 ? 188 ARG A CG  1 
ATOM   213  C CD  . ARG A 1 34 ? 7.191  -19.939 8.290   1.00 24.31 ? 188 ARG A CD  1 
ATOM   214  N NE  . ARG A 1 34 ? 8.314  -19.182 7.716   1.00 27.34 ? 188 ARG A NE  1 
ATOM   215  C CZ  . ARG A 1 34 ? 9.279  -19.739 6.981   1.00 28.92 ? 188 ARG A CZ  1 
ATOM   216  N NH1 . ARG A 1 34 ? 9.254  -21.044 6.713   1.00 26.84 ? 188 ARG A NH1 1 
ATOM   217  N NH2 . ARG A 1 34 ? 10.264 -18.997 6.499   1.00 27.50 ? 188 ARG A NH2 1 
ATOM   218  N N   . LEU A 1 35 ? 3.228  -16.687 5.970   1.00 20.77 ? 189 LEU A N   1 
ATOM   219  C CA  . LEU A 1 35 ? 2.775  -15.655 5.051   1.00 21.45 ? 189 LEU A CA  1 
ATOM   220  C C   . LEU A 1 35 ? 1.597  -14.859 5.630   1.00 22.28 ? 189 LEU A C   1 
ATOM   221  O O   . LEU A 1 35 ? 1.618  -13.638 5.597   1.00 22.71 ? 189 LEU A O   1 
ATOM   222  C CB  . LEU A 1 35 ? 2.451  -16.254 3.675   1.00 22.34 ? 189 LEU A CB  1 
ATOM   223  C CG  . LEU A 1 35 ? 1.921  -15.278 2.599   1.00 24.13 ? 189 LEU A CG  1 
ATOM   224  C CD1 . LEU A 1 35 ? 2.884  -14.135 2.365   1.00 24.88 ? 189 LEU A CD1 1 
ATOM   225  C CD2 . LEU A 1 35 ? 1.721  -15.983 1.306   1.00 26.28 ? 189 LEU A CD2 1 
ATOM   226  N N   . ALA A 1 36 ? 0.608  -15.533 6.193   1.00 22.49 ? 190 ALA A N   1 
ATOM   227  C CA  . ALA A 1 36 ? -0.548 -14.880 6.820   1.00 23.19 ? 190 ALA A CA  1 
ATOM   228  C C   . ALA A 1 36 ? -0.069 -14.019 8.019   1.00 23.63 ? 190 ALA A C   1 
ATOM   229  O O   . ALA A 1 36 ? -0.537 -12.904 8.184   1.00 24.30 ? 190 ALA A O   1 
ATOM   230  C CB  . ALA A 1 36 ? -1.534 -15.944 7.292   1.00 23.65 ? 190 ALA A CB  1 
ATOM   231  N N   . HIS A 1 37 ? 0.849  -14.529 8.843   1.00 23.05 ? 191 HIS A N   1 
ATOM   232  C CA  . HIS A 1 37 ? 1.401  -13.786 9.978   1.00 23.37 ? 191 HIS A CA  1 
ATOM   233  C C   . HIS A 1 37 ? 2.141  -12.497 9.543   1.00 23.24 ? 191 HIS A C   1 
ATOM   234  O O   . HIS A 1 37 ? 1.881  -11.417 10.079  1.00 21.49 ? 191 HIS A O   1 
ATOM   235  C CB  . HIS A 1 37 ? 2.328  -14.678 10.838  1.00 24.06 ? 191 HIS A CB  1 
ATOM   236  C CG  . HIS A 1 37 ? 2.988  -13.924 11.970  1.00 28.71 ? 191 HIS A CG  1 
ATOM   237  N ND1 . HIS A 1 37 ? 2.248  -13.405 13.034  1.00 31.72 ? 191 HIS A ND1 1 
ATOM   238  C CD2 . HIS A 1 37 ? 4.286  -13.595 12.151  1.00 30.67 ? 191 HIS A CD2 1 
ATOM   239  C CE1 . HIS A 1 37 ? 3.118  -12.773 13.810  1.00 32.24 ? 191 HIS A CE1 1 
ATOM   240  N NE2 . HIS A 1 37 ? 4.361  -12.879 13.335  1.00 31.84 ? 191 HIS A NE2 1 
ATOM   241  N N   . GLN A 1 38 ? 3.022  -12.617 8.539   1.00 22.38 ? 192 GLN A N   1 
ATOM   242  C CA  . GLN A 1 38 ? 3.749  -11.462 8.025   1.00 23.10 ? 192 GLN A CA  1 
ATOM   243  C C   . GLN A 1 38 ? 2.788  -10.451 7.398   1.00 21.80 ? 192 GLN A C   1 
ATOM   244  O O   . GLN A 1 38 ? 3.024  -9.266  7.562   1.00 21.40 ? 192 GLN A O   1 
ATOM   245  C CB  . GLN A 1 38 ? 4.814  -11.857 6.982   1.00 24.23 ? 192 GLN A CB  1 
ATOM   246  C CG  . GLN A 1 38 ? 6.004  -12.619 7.571   1.00 27.58 ? 192 GLN A CG  1 
ATOM   247  C CD  . GLN A 1 38 ? 6.775  -11.881 8.641   1.00 33.75 ? 192 GLN A CD  1 
ATOM   248  O OE1 . GLN A 1 38 ? 7.036  -12.434 9.711   1.00 37.21 ? 192 GLN A OE1 1 
ATOM   249  N NE2 . GLN A 1 38 ? 7.088  -10.614 8.416   1.00 31.59 ? 192 GLN A NE2 1 
ATOM   250  N N   . SER A 1 39 ? 1.725  -10.887 6.708   1.00 21.04 ? 193 SER A N   1 
ATOM   251  C CA  . SER A 1 39 ? 0.762  -9.962  6.097   1.00 21.90 ? 193 SER A CA  1 
ATOM   252  C C   . SER A 1 39 ? 0.049  -9.157  7.194   1.00 22.55 ? 193 SER A C   1 
ATOM   253  O O   . SER A 1 39 ? -0.154 -7.956  7.040   1.00 23.26 ? 193 SER A O   1 
ATOM   254  C CB  . SER A 1 39 ? -0.273 -10.708 5.252   1.00 22.68 ? 193 SER A CB  1 
ATOM   255  O OG  . SER A 1 39 ? 0.308  -11.350 4.127   1.00 26.23 ? 193 SER A OG  1 
ATOM   256  N N   . GLU A 1 40 ? -0.316 -9.806  8.306   1.00 22.22 ? 194 GLU A N   1 
ATOM   257  C CA  . GLU A 1 40 ? -0.978 -9.098  9.415   1.00 21.55 ? 194 GLU A CA  1 
ATOM   258  C C   . GLU A 1 40 ? -0.005 -8.066  10.024  1.00 21.52 ? 194 GLU A C   1 
ATOM   259  O O   . GLU A 1 40 ? -0.380 -6.942  10.302  1.00 20.90 ? 194 GLU A O   1 
ATOM   260  C CB  . GLU A 1 40 ? -1.413 -10.095 10.502  1.00 22.28 ? 194 GLU A CB  1 
ATOM   261  C CG  . GLU A 1 40 ? -2.596 -10.954 10.091  1.00 26.97 ? 194 GLU A CG  1 
ATOM   262  C CD  . GLU A 1 40 ? -3.055 -11.910 11.172  1.00 33.56 ? 194 GLU A CD  1 
ATOM   263  O OE1 . GLU A 1 40 ? -3.653 -12.956 10.829  1.00 35.22 ? 194 GLU A OE1 1 
ATOM   264  O OE2 . GLU A 1 40 ? -2.815 -11.620 12.363  1.00 34.77 ? 194 GLU A OE2 1 
ATOM   265  N N   . GLU A 1 41 ? 1.262  -8.477  10.226  1.00 21.47 ? 195 GLU A N   1 
ATOM   266  C CA  . GLU A 1 41 ? 2.267  -7.581  10.795  1.00 22.21 ? 195 GLU A CA  1 
ATOM   267  C C   . GLU A 1 41 ? 2.570  -6.436  9.854   1.00 21.97 ? 195 GLU A C   1 
ATOM   268  O O   . GLU A 1 41 ? 2.816  -5.315  10.327  1.00 22.55 ? 195 GLU A O   1 
ATOM   269  C CB  . GLU A 1 41 ? 3.551  -8.371  11.136  1.00 25.06 ? 195 GLU A CB  1 
ATOM   270  C CG  . GLU A 1 41 ? 3.401  -9.430  12.207  1.00 31.81 ? 195 GLU A CG  1 
ATOM   271  C CD  . GLU A 1 41 ? 3.221  -8.921  13.615  1.00 47.93 ? 195 GLU A CD  1 
ATOM   272  O OE1 . GLU A 1 41 ? 2.075  -8.597  13.999  1.00 51.40 ? 195 GLU A OE1 1 
ATOM   273  O OE2 . GLU A 1 41 ? 4.236  -8.845  14.342  1.00 54.19 ? 195 GLU A OE2 1 
ATOM   274  N N   . LYS A 1 42 ? 2.571  -6.679  8.532   1.00 21.14 ? 196 LYS A N   1 
ATOM   275  C CA  . LYS A 1 42 ? 2.818  -5.623  7.532   1.00 21.71 ? 196 LYS A CA  1 
ATOM   276  C C   . LYS A 1 42 ? 1.656  -4.621  7.582   1.00 22.85 ? 196 LYS A C   1 
ATOM   277  O O   . LYS A 1 42 ? 1.888  -3.420  7.657   1.00 23.01 ? 196 LYS A O   1 
ATOM   278  C CB  . LYS A 1 42 ? 2.936  -6.204  6.111   1.00 23.08 ? 196 LYS A CB  1 
ATOM   279  C CG  . LYS A 1 42 ? 3.197  -5.146  5.080   1.00 26.29 ? 196 LYS A CG  1 
ATOM   280  C CD  . LYS A 1 42 ? 3.210  -5.727  3.709   1.00 31.65 ? 196 LYS A CD  1 
ATOM   281  C CE  . LYS A 1 42 ? 2.135  -5.083  2.937   1.00 34.55 ? 196 LYS A CE  1 
ATOM   282  N NZ  . LYS A 1 42 ? 2.236  -5.425  1.485   1.00 36.06 ? 196 LYS A NZ  1 
ATOM   283  N N   . GLY A 1 43 ? 0.425  -5.131  7.634   1.00 22.52 ? 197 GLY A N   1 
ATOM   284  C CA  . GLY A 1 43 ? -0.766 -4.304  7.747   1.00 22.51 ? 197 GLY A CA  1 
ATOM   285  C C   . GLY A 1 43 ? -0.743 -3.434  8.986   1.00 23.83 ? 197 GLY A C   1 
ATOM   286  O O   . GLY A 1 43 ? -1.034 -2.233  8.891   1.00 25.16 ? 197 GLY A O   1 
ATOM   287  N N   . ALA A 1 44 ? -0.324 -3.999  10.135  1.00 22.58 ? 198 ALA A N   1 
ATOM   288  C CA  . ALA A 1 44 ? -0.221 -3.209  11.360  1.00 23.63 ? 198 ALA A CA  1 
ATOM   289  C C   . ALA A 1 44 ? 0.843  -2.090  11.232  1.00 24.65 ? 198 ALA A C   1 
ATOM   290  O O   . ALA A 1 44 ? 0.582  -0.930  11.620  1.00 24.76 ? 198 ALA A O   1 
ATOM   291  C CB  . ALA A 1 44 ? 0.080  -4.109  12.545  1.00 23.56 ? 198 ALA A CB  1 
ATOM   292  N N   . ALA A 1 45 ? 2.001  -2.413  10.649  1.00 24.65 ? 199 ALA A N   1 
ATOM   293  C CA  . ALA A 1 45 ? 3.084  -1.420  10.473  1.00 25.23 ? 199 ALA A CA  1 
ATOM   294  C C   . ALA A 1 45 ? 2.660  -0.298  9.538   1.00 26.56 ? 199 ALA A C   1 
ATOM   295  O O   . ALA A 1 45 ? 2.967  0.873   9.805   1.00 26.79 ? 199 ALA A O   1 
ATOM   296  C CB  . ALA A 1 45 ? 4.339  -2.097  9.920   1.00 25.15 ? 199 ALA A CB  1 
ATOM   297  N N   . LEU A 1 46 ? 1.938  -0.631  8.462   1.00 26.50 ? 200 LEU A N   1 
ATOM   298  C CA  . LEU A 1 46 ? 1.467  0.366   7.512   1.00 27.39 ? 200 LEU A CA  1 
ATOM   299  C C   . LEU A 1 46 ? 0.407  1.250   8.115   1.00 28.84 ? 200 LEU A C   1 
ATOM   300  O O   . LEU A 1 46 ? 0.365  2.421   7.760   1.00 30.88 ? 200 LEU A O   1 
ATOM   301  C CB  . LEU A 1 46 ? 0.927  -0.271  6.228   1.00 27.87 ? 200 LEU A CB  1 
ATOM   302  C CG  . LEU A 1 46 ? 1.983  -0.907  5.359   1.00 29.15 ? 200 LEU A CG  1 
ATOM   303  C CD1 . LEU A 1 46 ? 1.320  -1.649  4.230   1.00 30.28 ? 200 LEU A CD1 1 
ATOM   304  C CD2 . LEU A 1 46 ? 3.015  0.111   4.849   1.00 29.93 ? 200 LEU A CD2 1 
ATOM   305  N N   . MET A 1 47 ? -0.433 0.728   9.021   1.00 28.40 ? 201 MET A N   1 
ATOM   306  C CA  . MET A 1 47 ? -1.442 1.531   9.693   1.00 29.55 ? 201 MET A CA  1 
ATOM   307  C C   . MET A 1 47 ? -0.759 2.543   10.612  1.00 30.51 ? 201 MET A C   1 
ATOM   308  O O   . MET A 1 47 ? -1.142 3.714   10.629  1.00 30.54 ? 201 MET A O   1 
ATOM   309  C CB  . MET A 1 47 ? -2.358 0.652   10.541  1.00 29.91 ? 201 MET A CB  1 
ATOM   310  C CG  . MET A 1 47 ? -3.553 1.399   11.055  1.00 35.88 ? 201 MET A CG  1 
ATOM   311  S SD  . MET A 1 47 ? -4.390 0.464   12.341  1.00 54.29 ? 201 MET A SD  1 
ATOM   312  C CE  . MET A 1 47 ? -3.463 1.010   13.773  1.00 53.25 ? 201 MET A CE  1 
ATOM   313  N N   . ARG A 1 48 ? 0.267  2.100   11.359  1.00 30.34 ? 202 ARG A N   1 
ATOM   314  C CA  . ARG A 1 48 ? 1.037  2.980   12.244  1.00 31.03 ? 202 ARG A CA  1 
ATOM   315  C C   . ARG A 1 48 ? 1.702  4.089   11.411  1.00 30.79 ? 202 ARG A C   1 
ATOM   316  O O   . ARG A 1 48 ? 1.680  5.251   11.809  1.00 29.76 ? 202 ARG A O   1 
ATOM   317  C CB  . ARG A 1 48 ? 2.062  2.156   13.059  1.00 33.54 ? 202 ARG A CB  1 
ATOM   318  C CG  . ARG A 1 48 ? 2.918  2.973   14.031  1.00 38.58 ? 202 ARG A CG  1 
ATOM   319  C CD  . ARG A 1 48 ? 2.088  3.639   15.123  1.00 44.72 ? 202 ARG A CD  1 
ATOM   320  N NE  . ARG A 1 48 ? 2.911  4.401   16.076  1.00 48.86 ? 202 ARG A NE  1 
ATOM   321  C CZ  . ARG A 1 48 ? 2.514  5.523   16.672  1.00 52.35 ? 202 ARG A CZ  1 
ATOM   322  N NH1 . ARG A 1 48 ? 1.320  6.044   16.400  1.00 51.59 ? 202 ARG A NH1 1 
ATOM   323  N NH2 . ARG A 1 48 ? 3.316  6.148   17.528  1.00 53.09 ? 202 ARG A NH2 1 
ATOM   324  N N   . ASN A 1 49 ? 2.228  3.743   10.231  1.00 31.43 ? 203 ASN A N   1 
ATOM   325  C CA  . ASN A 1 49 ? 2.850  4.688   9.307   1.00 32.98 ? 203 ASN A CA  1 
ATOM   326  C C   . ASN A 1 49 ? 1.876  5.766   8.843   1.00 34.08 ? 203 ASN A C   1 
ATOM   327  O O   . ASN A 1 49 ? 2.249  6.938   8.790   1.00 34.58 ? 203 ASN A O   1 
ATOM   328  C CB  . ASN A 1 49 ? 3.422  3.937   8.099   1.00 35.44 ? 203 ASN A CB  1 
ATOM   329  C CG  . ASN A 1 49 ? 4.166  4.791   7.109   1.00 40.09 ? 203 ASN A CG  1 
ATOM   330  O OD1 . ASN A 1 49 ? 3.591  5.293   6.143   1.00 42.86 ? 203 ASN A OD1 1 
ATOM   331  N ND2 . ASN A 1 49 ? 5.459  5.001   7.336   1.00 39.84 ? 203 ASN A ND2 1 
ATOM   332  N N   . ARG A 1 50 ? 0.643  5.375   8.506   1.00 33.94 ? 204 ARG A N   1 
ATOM   333  C CA  . ARG A 1 50 ? -0.381 6.326   8.068   1.00 34.19 ? 204 ARG A CA  1 
ATOM   334  C C   . ARG A 1 50 ? -0.702 7.313   9.184   1.00 34.11 ? 204 ARG A C   1 
ATOM   335  O O   . ARG A 1 50 ? -0.742 8.515   8.925   1.00 34.79 ? 204 ARG A O   1 
ATOM   336  C CB  . ARG A 1 50 ? -1.647 5.595   7.607   1.00 34.98 ? 204 ARG A CB  1 
ATOM   337  C CG  . ARG A 1 50 ? -1.413 4.884   6.273   1.00 38.94 ? 204 ARG A CG  1 
ATOM   338  C CD  . ARG A 1 50 ? -2.702 4.389   5.635   1.00 42.37 ? 204 ARG A CD  1 
ATOM   339  N NE  . ARG A 1 50 ? -3.437 3.453   6.488   1.00 44.59 ? 204 ARG A NE  1 
ATOM   340  C CZ  . ARG A 1 50 ? -3.319 2.125   6.422   1.00 45.64 ? 204 ARG A CZ  1 
ATOM   341  N NH1 . ARG A 1 50 ? -2.521 1.564   5.522   1.00 44.92 ? 204 ARG A NH1 1 
ATOM   342  N NH2 . ARG A 1 50 ? -4.045 1.349   7.212   1.00 44.79 ? 204 ARG A NH2 1 
ATOM   343  N N   . ASP A 1 51 ? -0.851 6.826   10.423  1.00 33.56 ? 205 ASP A N   1 
ATOM   344  C CA  . ASP A 1 51 ? -1.144 7.661   11.588  1.00 34.15 ? 205 ASP A CA  1 
ATOM   345  C C   . ASP A 1 51 ? -0.019 8.655   11.873  1.00 34.59 ? 205 ASP A C   1 
ATOM   346  O O   . ASP A 1 51 ? -0.296 9.817   12.174  1.00 34.39 ? 205 ASP A O   1 
ATOM   347  C CB  . ASP A 1 51 ? -1.402 6.804   12.827  1.00 35.43 ? 205 ASP A CB  1 
ATOM   348  C CG  . ASP A 1 51 ? -2.676 5.983   12.771  1.00 40.42 ? 205 ASP A CG  1 
ATOM   349  O OD1 . ASP A 1 51 ? -3.533 6.269   11.898  1.00 41.36 ? 205 ASP A OD1 1 
ATOM   350  O OD2 . ASP A 1 51 ? -2.811 5.048   13.590  1.00 41.64 ? 205 ASP A OD2 1 
ATOM   351  N N   . LEU A 1 52 ? 1.239  8.198   11.775  1.00 34.29 ? 206 LEU A N   1 
ATOM   352  C CA  . LEU A 1 52 ? 2.406  9.068   11.984  1.00 35.49 ? 206 LEU A CA  1 
ATOM   353  C C   . LEU A 1 52 ? 2.497  10.131  10.894  1.00 37.25 ? 206 LEU A C   1 
ATOM   354  O O   . LEU A 1 52 ? 2.781  11.289  11.197  1.00 37.67 ? 206 LEU A O   1 
ATOM   355  C CB  . LEU A 1 52 ? 3.707  8.239   12.020  1.00 34.85 ? 206 LEU A CB  1 
ATOM   356  C CG  . LEU A 1 52 ? 3.846  7.310   13.225  1.00 35.67 ? 206 LEU A CG  1 
ATOM   357  C CD1 . LEU A 1 52 ? 5.044  6.382   13.077  1.00 35.82 ? 206 LEU A CD1 1 
ATOM   358  C CD2 . LEU A 1 52 ? 3.929  8.098   14.526  1.00 37.17 ? 206 LEU A CD2 1 
ATOM   359  N N   . GLN A 1 53 ? 2.233  9.756   9.635   1.00 38.81 ? 207 GLN A N   1 
ATOM   360  C CA  . GLN A 1 53 ? 2.276  10.716  8.535   1.00 40.93 ? 207 GLN A CA  1 
ATOM   361  C C   . GLN A 1 53 ? 1.218  11.807  8.717   1.00 42.64 ? 207 GLN A C   1 
ATOM   362  O O   . GLN A 1 53 ? 1.488  12.977  8.445   1.00 42.79 ? 207 GLN A O   1 
ATOM   363  C CB  . GLN A 1 53 ? 2.108  10.021  7.177   1.00 43.67 ? 207 GLN A CB  1 
ATOM   364  C CG  . GLN A 1 53 ? 2.358  10.936  5.981   1.00 49.13 ? 207 GLN A CG  1 
ATOM   365  C CD  . GLN A 1 53 ? 3.733  11.562  5.998   1.00 55.19 ? 207 GLN A CD  1 
ATOM   366  O OE1 . GLN A 1 53 ? 4.757  10.876  5.921   1.00 57.05 ? 207 GLN A OE1 1 
ATOM   367  N NE2 . GLN A 1 53 ? 3.789  12.887  6.095   1.00 56.68 ? 207 GLN A NE2 1 
ATOM   368  N N   . LEU A 1 54 ? 0.041  11.437  9.210   1.00 43.61 ? 208 LEU A N   1 
ATOM   369  C CA  . LEU A 1 54 ? -1.035 12.382  9.487   1.00 45.75 ? 208 LEU A CA  1 
ATOM   370  C C   . LEU A 1 54 ? -0.614 13.372  10.578  1.00 46.89 ? 208 LEU A C   1 
ATOM   371  O O   . LEU A 1 54 ? -0.952 14.542  10.470  1.00 47.43 ? 208 LEU A O   1 
ATOM   372  C CB  . LEU A 1 54 ? -2.288 11.608  9.945   1.00 46.73 ? 208 LEU A CB  1 
ATOM   373  C CG  . LEU A 1 54 ? -3.443 11.387  8.950   1.00 49.68 ? 208 LEU A CG  1 
ATOM   374  C CD1 . LEU A 1 54 ? -2.976 11.274  7.477   1.00 50.72 ? 208 LEU A CD1 1 
ATOM   375  C CD2 . LEU A 1 54 ? -4.254 10.180  9.341   1.00 50.45 ? 208 LEU A CD2 1 
ATOM   376  N N   . GLU A 1 55 ? 0.105  12.907  11.623  1.00 46.98 ? 209 GLU A N   1 
ATOM   377  C CA  . GLU A 1 55 ? 0.593  13.746  12.723  1.00 47.75 ? 209 GLU A CA  1 
ATOM   378  C C   . GLU A 1 55 ? 1.578  14.791  12.208  1.00 48.58 ? 209 GLU A C   1 
ATOM   379  O O   . GLU A 1 55 ? 1.471  15.962  12.578  1.00 48.95 ? 209 GLU A O   1 
ATOM   380  C CB  . GLU A 1 55 ? 1.293  12.888  13.793  1.00 49.95 ? 209 GLU A CB  1 
ATOM   381  C CG  . GLU A 1 55 ? 0.365  12.143  14.722  1.00 55.65 ? 209 GLU A CG  1 
ATOM   382  C CD  . GLU A 1 55 ? 1.088  11.417  15.841  1.00 63.32 ? 209 GLU A CD  1 
ATOM   383  O OE1 . GLU A 1 55 ? 1.958  12.042  16.490  1.00 62.40 ? 209 GLU A OE1 1 
ATOM   384  O OE2 . GLU A 1 55 ? 0.778  10.225  16.075  1.00 67.41 ? 209 GLU A OE2 1 
ATOM   385  N N   . ILE A 1 56 ? 2.544  14.361  11.372  1.00 48.50 ? 210 ILE A N   1 
ATOM   386  C CA  . ILE A 1 56 ? 3.569  15.215  10.770  1.00 49.68 ? 210 ILE A CA  1 
ATOM   387  C C   . ILE A 1 56 ? 2.955  16.313  9.905   1.00 49.78 ? 210 ILE A C   1 
ATOM   388  O O   . ILE A 1 56 ? 3.377  17.471  9.987   1.00 49.12 ? 210 ILE A O   1 
ATOM   389  C CB  . ILE A 1 56 ? 4.536  14.337  9.946   1.00 51.22 ? 210 ILE A CB  1 
ATOM   390  C CG1 . ILE A 1 56 ? 5.392  13.517  10.881  1.00 53.06 ? 210 ILE A CG1 1 
ATOM   391  C CG2 . ILE A 1 56 ? 5.410  15.165  8.996   1.00 52.05 ? 210 ILE A CG2 1 
ATOM   392  C CD1 . ILE A 1 56 ? 6.085  12.466  10.273  1.00 54.88 ? 210 ILE A CD1 1 
ATOM   393  N N   . ASP A 1 57 ? 1.975  15.943  9.071   1.00 49.85 ? 211 ASP A N   1 
ATOM   394  C CA  . ASP A 1 57 ? 1.302  16.875  8.173   1.00 50.84 ? 211 ASP A CA  1 
ATOM   395  C C   . ASP A 1 57 ? 0.584  18.004  8.930   1.00 50.60 ? 211 ASP A C   1 
ATOM   396  O O   . ASP A 1 57 ? 0.476  19.114  8.408   1.00 50.72 ? 211 ASP A O   1 
ATOM   397  C CB  . ASP A 1 57 ? 0.320  16.116  7.266   1.00 53.30 ? 211 ASP A CB  1 
ATOM   398  C CG  . ASP A 1 57 ? 0.965  15.246  6.207   1.00 59.50 ? 211 ASP A CG  1 
ATOM   399  O OD1 . ASP A 1 57 ? 0.236  14.449  5.567   1.00 61.10 ? 211 ASP A OD1 1 
ATOM   400  O OD2 . ASP A 1 57 ? 2.196  15.353  6.016   1.00 62.41 ? 211 ASP A OD2 1 
ATOM   401  N N   . GLN A 1 58 ? 0.129  17.734  10.161  1.00 50.28 ? 212 GLN A N   1 
ATOM   402  C CA  . GLN A 1 58 ? -0.530 18.725  11.006  1.00 50.83 ? 212 GLN A CA  1 
ATOM   403  C C   . GLN A 1 58 ? 0.473  19.683  11.669  1.00 51.01 ? 212 GLN A C   1 
ATOM   404  O O   . GLN A 1 58 ? 0.115  20.819  11.973  1.00 51.38 ? 212 GLN A O   1 
ATOM   405  C CB  . GLN A 1 58 ? -1.381 18.030  12.079  1.00 52.38 ? 212 GLN A CB  1 
ATOM   406  C CG  . GLN A 1 58 ? -2.568 17.258  11.498  1.00 57.04 ? 212 GLN A CG  1 
ATOM   407  C CD  . GLN A 1 58 ? -3.187 16.238  12.443  1.00 62.93 ? 212 GLN A CD  1 
ATOM   408  O OE1 . GLN A 1 58 ? -4.100 15.490  12.059  1.00 64.12 ? 212 GLN A OE1 1 
ATOM   409  N NE2 . GLN A 1 58 ? -2.709 16.156  13.692  1.00 63.97 ? 212 GLN A NE2 1 
ATOM   410  N N   . LEU A 1 59 ? 1.712  19.235  11.898  1.00 50.67 ? 213 LEU A N   1 
ATOM   411  C CA  . LEU A 1 59 ? 2.731  20.064  12.535  1.00 51.41 ? 213 LEU A CA  1 
ATOM   412  C C   . LEU A 1 59 ? 3.533  20.891  11.530  1.00 52.40 ? 213 LEU A C   1 
ATOM   413  O O   . LEU A 1 59 ? 3.905  22.022  11.826  1.00 52.28 ? 213 LEU A O   1 
ATOM   414  C CB  . LEU A 1 59 ? 3.683  19.200  13.361  1.00 51.67 ? 213 LEU A CB  1 
ATOM   415  C CG  . LEU A 1 59 ? 3.046  18.376  14.457  1.00 53.20 ? 213 LEU A CG  1 
ATOM   416  C CD1 . LEU A 1 59 ? 4.044  17.381  15.055  1.00 53.57 ? 213 LEU A CD1 1 
ATOM   417  C CD2 . LEU A 1 59 ? 2.462  19.265  15.517  1.00 54.01 ? 213 LEU A CD2 1 
ATOM   418  N N   . LYS A 1 60 ? 3.827  20.310  10.359  1.00 52.82 ? 214 LYS A N   1 
ATOM   419  C CA  . LYS A 1 60 ? 4.599  20.977  9.313   1.00 53.86 ? 214 LYS A CA  1 
ATOM   420  C C   . LYS A 1 60 ? 3.718  21.878  8.460   1.00 54.76 ? 214 LYS A C   1 
ATOM   421  O O   . LYS A 1 60 ? 2.679  21.441  7.963   1.00 55.56 ? 214 LYS A O   1 
ATOM   422  C CB  . LYS A 1 60 ? 5.317  19.944  8.431   1.00 55.37 ? 214 LYS A CB  1 
ATOM   423  C CG  . LYS A 1 60 ? 6.574  19.397  9.075   1.00 58.91 ? 214 LYS A CG  1 
ATOM   424  C CD  . LYS A 1 60 ? 7.250  18.293  8.267   1.00 62.21 ? 214 LYS A CD  1 
ATOM   425  C CE  . LYS A 1 60 ? 7.725  18.740  6.913   1.00 65.53 ? 214 LYS A CE  1 
ATOM   426  N NZ  . LYS A 1 60 ? 8.850  17.902  6.418   1.00 67.21 ? 214 LYS A NZ  1 
ATOM   427  N N   . ARG B 1 6  ? -0.553 -55.528 -10.226 1.00 58.45 ? 160 ARG B N   1 
ATOM   428  C CA  . ARG B 1 6  ? -0.013 -54.785 -9.089  1.00 59.23 ? 160 ARG B CA  1 
ATOM   429  C C   . ARG B 1 6  ? 1.160  -53.896 -9.517  1.00 60.31 ? 160 ARG B C   1 
ATOM   430  O O   . ARG B 1 6  ? 1.256  -52.760 -9.062  1.00 60.32 ? 160 ARG B O   1 
ATOM   431  C CB  . ARG B 1 6  ? 0.406  -55.748 -7.964  1.00 60.05 ? 160 ARG B CB  1 
ATOM   432  C CG  . ARG B 1 6  ? 0.818  -55.061 -6.667  1.00 61.91 ? 160 ARG B CG  1 
ATOM   433  C CD  . ARG B 1 6  ? 1.250  -56.067 -5.613  1.00 62.87 ? 160 ARG B CD  1 
ATOM   434  N NE  . ARG B 1 6  ? 1.841  -55.426 -4.436  1.00 62.82 ? 160 ARG B NE  1 
ATOM   435  C CZ  . ARG B 1 6  ? 3.135  -55.159 -4.296  1.00 62.77 ? 160 ARG B CZ  1 
ATOM   436  N NH1 . ARG B 1 6  ? 3.991  -55.459 -5.265  1.00 61.57 ? 160 ARG B NH1 1 
ATOM   437  N NH2 . ARG B 1 6  ? 3.582  -54.579 -3.191  1.00 62.31 ? 160 ARG B NH2 1 
ATOM   438  N N   . VAL B 1 7  ? 2.025  -54.399 -10.415 1.00 60.97 ? 161 VAL B N   1 
ATOM   439  C CA  . VAL B 1 7  ? 3.197  -53.686 -10.943 1.00 62.26 ? 161 VAL B CA  1 
ATOM   440  C C   . VAL B 1 7  ? 2.807  -52.402 -11.693 1.00 63.30 ? 161 VAL B C   1 
ATOM   441  O O   . VAL B 1 7  ? 3.394  -51.339 -11.465 1.00 63.61 ? 161 VAL B O   1 
ATOM   442  C CB  . VAL B 1 7  ? 4.047  -54.646 -11.824 1.00 63.24 ? 161 VAL B CB  1 
ATOM   443  C CG1 . VAL B 1 7  ? 5.061  -53.895 -12.688 1.00 63.99 ? 161 VAL B CG1 1 
ATOM   444  C CG2 . VAL B 1 7  ? 4.740  -55.700 -10.968 1.00 63.75 ? 161 VAL B CG2 1 
ATOM   445  N N   . GLN B 1 8  ? 1.821  -52.507 -12.585 1.00 63.64 ? 162 GLN B N   1 
ATOM   446  C CA  . GLN B 1 8  ? 1.353  -51.351 -13.341 1.00 64.47 ? 162 GLN B CA  1 
ATOM   447  C C   . GLN B 1 8  ? 0.617  -50.337 -12.454 1.00 64.80 ? 162 GLN B C   1 
ATOM   448  O O   . GLN B 1 8  ? 0.669  -49.141 -12.739 1.00 65.32 ? 162 GLN B O   1 
ATOM   449  C CB  . GLN B 1 8  ? 0.503  -51.777 -14.548 1.00 66.30 ? 162 GLN B CB  1 
ATOM   450  C CG  . GLN B 1 8  ? 1.330  -52.355 -15.694 1.00 70.34 ? 162 GLN B CG  1 
ATOM   451  C CD  . GLN B 1 8  ? 2.327  -51.360 -16.246 1.00 75.38 ? 162 GLN B CD  1 
ATOM   452  O OE1 . GLN B 1 8  ? 3.537  -51.620 -16.301 1.00 77.31 ? 162 GLN B OE1 1 
ATOM   453  N NE2 . GLN B 1 8  ? 1.844  -50.195 -16.662 1.00 75.92 ? 162 GLN B NE2 1 
ATOM   454  N N   . ARG B 1 9  ? -0.029 -50.802 -11.366 1.00 64.32 ? 163 ARG B N   1 
ATOM   455  C CA  . ARG B 1 9  ? -0.722 -49.919 -10.429 1.00 64.41 ? 163 ARG B CA  1 
ATOM   456  C C   . ARG B 1 9  ? 0.281  -49.054 -9.654  1.00 64.13 ? 163 ARG B C   1 
ATOM   457  O O   . ARG B 1 9  ? 0.100  -47.836 -9.596  1.00 64.39 ? 163 ARG B O   1 
ATOM   458  C CB  . ARG B 1 9  ? -1.626 -50.714 -9.462  1.00 65.93 ? 163 ARG B CB  1 
ATOM   459  C CG  . ARG B 1 9  ? -2.313 -49.836 -8.405  1.00 69.24 ? 163 ARG B CG  1 
ATOM   460  C CD  . ARG B 1 9  ? -3.252 -50.595 -7.470  1.00 72.48 ? 163 ARG B CD  1 
ATOM   461  N NE  . ARG B 1 9  ? -2.586 -51.684 -6.748  1.00 75.32 ? 163 ARG B NE  1 
ATOM   462  C CZ  . ARG B 1 9  ? -1.894 -51.530 -5.623  1.00 77.22 ? 163 ARG B CZ  1 
ATOM   463  N NH1 . ARG B 1 9  ? -1.754 -50.326 -5.080  1.00 77.23 ? 163 ARG B NH1 1 
ATOM   464  N NH2 . ARG B 1 9  ? -1.324 -52.577 -5.040  1.00 76.43 ? 163 ARG B NH2 1 
ATOM   465  N N   . LEU B 1 10 ? 1.343  -49.659 -9.085  1.00 63.54 ? 164 LEU B N   1 
ATOM   466  C CA  . LEU B 1 10 ? 2.333  -48.875 -8.341  1.00 63.59 ? 164 LEU B CA  1 
ATOM   467  C C   . LEU B 1 10 ? 3.157  -47.958 -9.244  1.00 63.26 ? 164 LEU B C   1 
ATOM   468  O O   . LEU B 1 10 ? 3.632  -46.933 -8.771  1.00 62.79 ? 164 LEU B O   1 
ATOM   469  C CB  . LEU B 1 10 ? 3.227  -49.714 -7.417  1.00 64.11 ? 164 LEU B CB  1 
ATOM   470  C CG  . LEU B 1 10 ? 3.733  -51.049 -7.925  1.00 66.20 ? 164 LEU B CG  1 
ATOM   471  C CD1 . LEU B 1 10 ? 5.111  -50.913 -8.539  1.00 67.16 ? 164 LEU B CD1 1 
ATOM   472  C CD2 . LEU B 1 10 ? 3.789  -52.069 -6.788  1.00 66.87 ? 164 LEU B CD2 1 
ATOM   473  N N   . LYS B 1 11 ? 3.283  -48.288 -10.542 1.00 63.39 ? 165 LYS B N   1 
ATOM   474  C CA  . LYS B 1 11 ? 3.982  -47.445 -11.514 1.00 63.94 ? 165 LYS B CA  1 
ATOM   475  C C   . LYS B 1 11 ? 3.206  -46.128 -11.682 1.00 63.52 ? 165 LYS B C   1 
ATOM   476  O O   . LYS B 1 11 ? 3.797  -45.049 -11.622 1.00 63.38 ? 165 LYS B O   1 
ATOM   477  C CB  . LYS B 1 11 ? 4.106  -48.193 -12.860 1.00 66.61 ? 165 LYS B CB  1 
ATOM   478  C CG  . LYS B 1 11 ? 4.511  -47.340 -14.056 1.00 71.80 ? 165 LYS B CG  1 
ATOM   479  C CD  . LYS B 1 11 ? 4.546  -48.179 -15.337 1.00 76.94 ? 165 LYS B CD  1 
ATOM   480  C CE  . LYS B 1 11 ? 4.126  -47.409 -16.575 1.00 81.43 ? 165 LYS B CE  1 
ATOM   481  N NZ  . LYS B 1 11 ? 5.122  -46.382 -16.959 1.00 84.10 ? 165 LYS B NZ  1 
ATOM   482  N N   . GLU B 1 12 ? 1.882  -46.224 -11.881 1.00 63.05 ? 166 GLU B N   1 
ATOM   483  C CA  . GLU B 1 12 ? 1.039  -45.050 -12.045 1.00 63.16 ? 166 GLU B CA  1 
ATOM   484  C C   . GLU B 1 12 ? 1.067  -44.187 -10.786 1.00 62.29 ? 166 GLU B C   1 
ATOM   485  O O   . GLU B 1 12 ? 1.282  -42.982 -10.889 1.00 62.11 ? 166 GLU B O   1 
ATOM   486  C CB  . GLU B 1 12 ? -0.398 -45.447 -12.500 1.00 66.25 ? 166 GLU B CB  1 
ATOM   487  C CG  . GLU B 1 12 ? -1.588 -44.823 -11.765 1.00 72.05 ? 166 GLU B CG  1 
ATOM   488  C CD  . GLU B 1 12 ? -1.963 -43.383 -12.079 1.00 78.96 ? 166 GLU B CD  1 
ATOM   489  O OE1 . GLU B 1 12 ? -2.982 -42.911 -11.523 1.00 80.68 ? 166 GLU B OE1 1 
ATOM   490  O OE2 . GLU B 1 12 ? -1.245 -42.724 -12.867 1.00 80.71 ? 166 GLU B OE2 1 
ATOM   491  N N   . GLU B 1 13 ? 0.903  -44.811 -9.609  1.00 61.41 ? 167 GLU B N   1 
ATOM   492  C CA  . GLU B 1 13 ? 0.884  -44.123 -8.314  1.00 60.97 ? 167 GLU B CA  1 
ATOM   493  C C   . GLU B 1 13 ? 2.163  -43.335 -8.071  1.00 59.80 ? 167 GLU B C   1 
ATOM   494  O O   . GLU B 1 13 ? 2.120  -42.223 -7.551  1.00 59.85 ? 167 GLU B O   1 
ATOM   495  C CB  . GLU B 1 13 ? 0.637  -45.128 -7.177  1.00 63.56 ? 167 GLU B CB  1 
ATOM   496  C CG  . GLU B 1 13 ? -0.786 -45.130 -6.650  1.00 69.54 ? 167 GLU B CG  1 
ATOM   497  C CD  . GLU B 1 13 ? -1.883 -45.235 -7.694  1.00 77.82 ? 167 GLU B CD  1 
ATOM   498  O OE1 . GLU B 1 13 ? -2.712 -44.300 -7.779  1.00 80.15 ? 167 GLU B OE1 1 
ATOM   499  O OE2 . GLU B 1 13 ? -1.909 -46.245 -8.435  1.00 80.07 ? 167 GLU B OE2 1 
ATOM   500  N N   . CYS B 1 14 ? 3.292  -43.907 -8.481  1.00 58.61 ? 168 CYS B N   1 
ATOM   501  C CA  . CYS B 1 14 ? 4.605  -43.305 -8.361  1.00 57.90 ? 168 CYS B CA  1 
ATOM   502  C C   . CYS B 1 14 ? 4.755  -42.126 -9.318  1.00 56.91 ? 168 CYS B C   1 
ATOM   503  O O   . CYS B 1 14 ? 5.267  -41.075 -8.919  1.00 56.53 ? 168 CYS B O   1 
ATOM   504  C CB  . CYS B 1 14 ? 5.667  -44.363 -8.598  1.00 58.70 ? 168 CYS B CB  1 
ATOM   505  S SG  . CYS B 1 14 ? 5.670  -45.681 -7.349  1.00 63.09 ? 168 CYS B SG  1 
ATOM   506  N N   . GLU B 1 15 ? 4.266  -42.279 -10.564 1.00 55.79 ? 169 GLU B N   1 
ATOM   507  C CA  . GLU B 1 15 ? 4.299  -41.203 -11.556 1.00 55.08 ? 169 GLU B CA  1 
ATOM   508  C C   . GLU B 1 15 ? 3.447  -40.014 -11.094 1.00 53.89 ? 169 GLU B C   1 
ATOM   509  O O   . GLU B 1 15 ? 3.838  -38.858 -11.289 1.00 54.11 ? 169 GLU B O   1 
ATOM   510  C CB  . GLU B 1 15 ? 3.786  -41.701 -12.913 1.00 57.17 ? 169 GLU B CB  1 
ATOM   511  C CG  . GLU B 1 15 ? 4.750  -42.604 -13.658 1.00 61.81 ? 169 GLU B CG  1 
ATOM   512  C CD  . GLU B 1 15 ? 4.135  -43.386 -14.807 1.00 66.52 ? 169 GLU B CD  1 
ATOM   513  O OE1 . GLU B 1 15 ? 2.895  -43.333 -14.980 1.00 67.44 ? 169 GLU B OE1 1 
ATOM   514  O OE2 . GLU B 1 15 ? 4.895  -44.069 -15.529 1.00 67.60 ? 169 GLU B OE2 1 
ATOM   515  N N   . ALA B 1 16 ? 2.283  -40.308 -10.479 1.00 52.22 ? 170 ALA B N   1 
ATOM   516  C CA  . ALA B 1 16 ? 1.358  -39.312 -9.956  1.00 51.08 ? 170 ALA B CA  1 
ATOM   517  C C   . ALA B 1 16 ? 1.986  -38.534 -8.792  1.00 49.83 ? 170 ALA B C   1 
ATOM   518  O O   . ALA B 1 16 ? 1.828  -37.314 -8.708  1.00 49.29 ? 170 ALA B O   1 
ATOM   519  C CB  . ALA B 1 16 ? 0.070  -39.980 -9.509  1.00 51.00 ? 170 ALA B CB  1 
ATOM   520  N N   . GLY B 1 17 ? 2.711  -39.237 -7.927  1.00 48.84 ? 171 GLY B N   1 
ATOM   521  C CA  . GLY B 1 17 ? 3.394  -38.628 -6.792  1.00 48.24 ? 171 GLY B CA  1 
ATOM   522  C C   . GLY B 1 17 ? 4.538  -37.732 -7.233  1.00 47.29 ? 171 GLY B C   1 
ATOM   523  O O   . GLY B 1 17 ? 4.732  -36.654 -6.669  1.00 46.92 ? 171 GLY B O   1 
ATOM   524  N N   . SER B 1 18 ? 5.271  -38.146 -8.275  1.00 46.61 ? 172 SER B N   1 
ATOM   525  C CA  . SER B 1 18 ? 6.366  -37.343 -8.822  1.00 47.13 ? 172 SER B CA  1 
ATOM   526  C C   . SER B 1 18 ? 5.847  -36.020 -9.430  1.00 47.04 ? 172 SER B C   1 
ATOM   527  O O   . SER B 1 18 ? 6.536  -34.988 -9.382  1.00 46.90 ? 172 SER B O   1 
ATOM   528  C CB  . SER B 1 18 ? 7.146  -38.142 -9.862  1.00 48.98 ? 172 SER B CB  1 
ATOM   529  O OG  . SER B 1 18 ? 8.339  -37.477 -10.246 1.00 51.70 ? 172 SER B OG  1 
ATOM   530  N N   . ARG B 1 19 ? 4.624  -36.054 -9.981  1.00 46.70 ? 173 ARG B N   1 
ATOM   531  C CA  . ARG B 1 19 ? 3.992  -34.876 -10.546 1.00 47.11 ? 173 ARG B CA  1 
ATOM   532  C C   . ARG B 1 19 ? 3.460  -33.976 -9.429  1.00 45.38 ? 173 ARG B C   1 
ATOM   533  O O   . ARG B 1 19 ? 3.607  -32.759 -9.509  1.00 45.09 ? 173 ARG B O   1 
ATOM   534  C CB  . ARG B 1 19 ? 2.873  -35.264 -11.523 1.00 49.95 ? 173 ARG B CB  1 
ATOM   535  C CG  . ARG B 1 19 ? 3.405  -35.783 -12.855 1.00 55.53 ? 173 ARG B CG  1 
ATOM   536  C CD  . ARG B 1 19 ? 2.302  -35.965 -13.887 1.00 60.57 ? 173 ARG B CD  1 
ATOM   537  N NE  . ARG B 1 19 ? 1.762  -37.328 -13.887 1.00 64.74 ? 173 ARG B NE  1 
ATOM   538  C CZ  . ARG B 1 19 ? 0.638  -37.689 -13.273 1.00 67.39 ? 173 ARG B CZ  1 
ATOM   539  N NH1 . ARG B 1 19 ? -0.090 -36.790 -12.619 1.00 67.54 ? 173 ARG B NH1 1 
ATOM   540  N NH2 . ARG B 1 19 ? 0.222  -38.946 -13.326 1.00 66.56 ? 173 ARG B NH2 1 
ATOM   541  N N   . GLU B 1 20 ? 2.863  -34.572 -8.381  1.00 43.84 ? 174 GLU B N   1 
ATOM   542  C CA  . GLU B 1 20 ? 2.360  -33.807 -7.244  1.00 43.24 ? 174 GLU B CA  1 
ATOM   543  C C   . GLU B 1 20 ? 3.516  -33.125 -6.473  1.00 41.18 ? 174 GLU B C   1 
ATOM   544  O O   . GLU B 1 20 ? 3.358  -31.990 -6.004  1.00 41.11 ? 174 GLU B O   1 
ATOM   545  C CB  . GLU B 1 20 ? 1.534  -34.697 -6.312  1.00 46.67 ? 174 GLU B CB  1 
ATOM   546  C CG  . GLU B 1 20 ? 0.861  -33.916 -5.196  1.00 53.56 ? 174 GLU B CG  1 
ATOM   547  C CD  . GLU B 1 20 ? -0.097 -34.696 -4.316  1.00 64.25 ? 174 GLU B CD  1 
ATOM   548  O OE1 . GLU B 1 20 ? -0.004 -35.945 -4.276  1.00 66.74 ? 174 GLU B OE1 1 
ATOM   549  O OE2 . GLU B 1 20 ? -0.942 -34.048 -3.657  1.00 68.09 ? 174 GLU B OE2 1 
ATOM   550  N N   . LEU B 1 21 ? 4.675  -33.789 -6.377  1.00 39.22 ? 175 LEU B N   1 
ATOM   551  C CA  . LEU B 1 21 ? 5.835  -33.209 -5.690  1.00 38.17 ? 175 LEU B CA  1 
ATOM   552  C C   . LEU B 1 21 ? 6.347  -31.995 -6.470  1.00 37.70 ? 175 LEU B C   1 
ATOM   553  O O   . LEU B 1 21 ? 6.646  -30.960 -5.879  1.00 36.50 ? 175 LEU B O   1 
ATOM   554  C CB  . LEU B 1 21 ? 6.952  -34.258 -5.539  1.00 38.41 ? 175 LEU B CB  1 
ATOM   555  C CG  . LEU B 1 21 ? 8.281  -33.751 -4.956  1.00 39.11 ? 175 LEU B CG  1 
ATOM   556  C CD1 . LEU B 1 21 ? 8.084  -33.184 -3.541  1.00 38.84 ? 175 LEU B CD1 1 
ATOM   557  C CD2 . LEU B 1 21 ? 9.332  -34.839 -4.994  1.00 39.65 ? 175 LEU B CD2 1 
ATOM   558  N N   . LYS B 1 22 ? 6.392  -32.101 -7.806  1.00 38.28 ? 176 LYS B N   1 
ATOM   559  C CA  . LYS B 1 22 ? 6.815  -31.011 -8.686  1.00 38.84 ? 176 LYS B CA  1 
ATOM   560  C C   . LYS B 1 22 ? 5.913  -29.784 -8.485  1.00 38.32 ? 176 LYS B C   1 
ATOM   561  O O   . LYS B 1 22 ? 6.409  -28.666 -8.372  1.00 38.23 ? 176 LYS B O   1 
ATOM   562  C CB  . LYS B 1 22 ? 6.765  -31.480 -10.159 1.00 42.12 ? 176 LYS B CB  1 
ATOM   563  C CG  . LYS B 1 22 ? 7.084  -30.383 -11.169 1.00 48.41 ? 176 LYS B CG  1 
ATOM   564  C CD  . LYS B 1 22 ? 7.175  -30.923 -12.588 1.00 54.10 ? 176 LYS B CD  1 
ATOM   565  C CE  . LYS B 1 22 ? 7.338  -29.822 -13.607 1.00 58.57 ? 176 LYS B CE  1 
ATOM   566  N NZ  . LYS B 1 22 ? 8.570  -29.027 -13.383 1.00 61.60 ? 176 LYS B NZ  1 
ATOM   567  N N   . ARG B 1 23 ? 4.601  -30.011 -8.380  1.00 37.65 ? 177 ARG B N   1 
ATOM   568  C CA  . ARG B 1 23 ? 3.593  -28.980 -8.166  1.00 38.21 ? 177 ARG B CA  1 
ATOM   569  C C   . ARG B 1 23 ? 3.779  -28.317 -6.798  1.00 36.71 ? 177 ARG B C   1 
ATOM   570  O O   . ARG B 1 23 ? 3.718  -27.091 -6.677  1.00 36.52 ? 177 ARG B O   1 
ATOM   571  C CB  . ARG B 1 23 ? 2.213  -29.634 -8.225  1.00 41.25 ? 177 ARG B CB  1 
ATOM   572  C CG  . ARG B 1 23 ? 1.063  -28.718 -8.564  1.00 47.53 ? 177 ARG B CG  1 
ATOM   573  C CD  . ARG B 1 23 ? -0.183 -29.556 -8.828  1.00 52.31 ? 177 ARG B CD  1 
ATOM   574  N NE  . ARG B 1 23 ? 0.058  -30.591 -9.840  1.00 54.89 ? 177 ARG B NE  1 
ATOM   575  C CZ  . ARG B 1 23 ? -0.202 -31.885 -9.675  1.00 57.20 ? 177 ARG B CZ  1 
ATOM   576  N NH1 . ARG B 1 23 ? -0.749 -32.323 -8.545  1.00 56.42 ? 177 ARG B NH1 1 
ATOM   577  N NH2 . ARG B 1 23 ? 0.060  -32.747 -10.645 1.00 57.36 ? 177 ARG B NH2 1 
ATOM   578  N N   . CYS B 1 24 ? 4.012  -29.140 -5.777  1.00 34.69 ? 178 CYS B N   1 
ATOM   579  C CA  . CYS B 1 24 ? 4.176  -28.670 -4.419  1.00 33.56 ? 178 CYS B CA  1 
ATOM   580  C C   . CYS B 1 24 ? 5.431  -27.796 -4.281  1.00 31.84 ? 178 CYS B C   1 
ATOM   581  O O   . CYS B 1 24 ? 5.373  -26.753 -3.638  1.00 31.20 ? 178 CYS B O   1 
ATOM   582  C CB  . CYS B 1 24 ? 4.184  -29.856 -3.455  1.00 34.02 ? 178 CYS B CB  1 
ATOM   583  S SG  . CYS B 1 24 ? 4.141  -29.384 -1.703  1.00 36.91 ? 178 CYS B SG  1 
ATOM   584  N N   . LYS B 1 25 ? 6.544  -28.192 -4.914  1.00 30.85 ? 179 LYS B N   1 
ATOM   585  C CA  . LYS B 1 25 ? 7.779  -27.419 -4.858  1.00 31.14 ? 179 LYS B CA  1 
ATOM   586  C C   . LYS B 1 25 ? 7.624  -26.076 -5.552  1.00 31.13 ? 179 LYS B C   1 
ATOM   587  O O   . LYS B 1 25 ? 8.106  -25.080 -5.025  1.00 30.22 ? 179 LYS B O   1 
ATOM   588  C CB  . LYS B 1 25 ? 8.938  -28.204 -5.455  1.00 33.80 ? 179 LYS B CB  1 
ATOM   589  C CG  . LYS B 1 25 ? 9.434  -29.349 -4.595  1.00 38.90 ? 179 LYS B CG  1 
ATOM   590  C CD  . LYS B 1 25 ? 10.575 -30.011 -5.323  1.00 45.38 ? 179 LYS B CD  1 
ATOM   591  C CE  . LYS B 1 25 ? 11.284 -31.079 -4.529  1.00 51.47 ? 179 LYS B CE  1 
ATOM   592  N NZ  . LYS B 1 25 ? 12.249 -31.845 -5.385  1.00 53.89 ? 179 LYS B NZ  1 
ATOM   593  N N   . GLU B 1 26 ? 6.906  -26.025 -6.686  1.00 31.16 ? 180 GLU B N   1 
ATOM   594  C CA  . GLU B 1 26 ? 6.632  -24.771 -7.402  1.00 32.11 ? 180 GLU B CA  1 
ATOM   595  C C   . GLU B 1 26 ? 5.784  -23.825 -6.537  1.00 31.43 ? 180 GLU B C   1 
ATOM   596  O O   . GLU B 1 26 ? 6.080  -22.621 -6.464  1.00 31.85 ? 180 GLU B O   1 
ATOM   597  C CB  . GLU B 1 26 ? 5.890  -25.051 -8.722  1.00 35.98 ? 180 GLU B CB  1 
ATOM   598  C CG  . GLU B 1 26 ? 6.796  -25.622 -9.791  1.00 42.35 ? 180 GLU B CG  1 
ATOM   599  C CD  . GLU B 1 26 ? 6.085  -26.208 -11.000 1.00 53.21 ? 180 GLU B CD  1 
ATOM   600  O OE1 . GLU B 1 26 ? 4.831  -26.291 -10.989 1.00 56.02 ? 180 GLU B OE1 1 
ATOM   601  O OE2 . GLU B 1 26 ? 6.793  -26.606 -11.953 1.00 55.04 ? 180 GLU B OE2 1 
ATOM   602  N N   . GLU B 1 27 ? 4.753  -24.373 -5.860  1.00 29.69 ? 181 GLU B N   1 
ATOM   603  C CA  . GLU B 1 27 ? 3.896  -23.582 -4.981  1.00 29.47 ? 181 GLU B CA  1 
ATOM   604  C C   . GLU B 1 27 ? 4.673  -23.056 -3.783  1.00 27.66 ? 181 GLU B C   1 
ATOM   605  O O   . GLU B 1 27 ? 4.441  -21.923 -3.344  1.00 28.03 ? 181 GLU B O   1 
ATOM   606  C CB  . GLU B 1 27 ? 2.733  -24.430 -4.449  1.00 32.34 ? 181 GLU B CB  1 
ATOM   607  C CG  . GLU B 1 27 ? 1.643  -24.676 -5.476  1.00 39.81 ? 181 GLU B CG  1 
ATOM   608  C CD  . GLU B 1 27 ? 0.640  -25.752 -5.121  1.00 50.78 ? 181 GLU B CD  1 
ATOM   609  O OE1 . GLU B 1 27 ? 0.010  -26.284 -6.061  1.00 55.47 ? 181 GLU B OE1 1 
ATOM   610  O OE2 . GLU B 1 27 ? 0.511  -26.097 -3.924  1.00 52.99 ? 181 GLU B OE2 1 
ATOM   611  N N   . ASN B 1 28 ? 5.564  -23.905 -3.239  1.00 26.29 ? 182 ASN B N   1 
ATOM   612  C CA  . ASN B 1 28 ? 6.361  -23.539 -2.076  1.00 26.42 ? 182 ASN B CA  1 
ATOM   613  C C   . ASN B 1 28 ? 7.323  -22.420 -2.432  1.00 27.34 ? 182 ASN B C   1 
ATOM   614  O O   . ASN B 1 28 ? 7.481  -21.526 -1.609  1.00 26.38 ? 182 ASN B O   1 
ATOM   615  C CB  . ASN B 1 28 ? 7.081  -24.763 -1.492  1.00 26.85 ? 182 ASN B CB  1 
ATOM   616  C CG  . ASN B 1 28 ? 6.171  -25.621 -0.609  1.00 27.76 ? 182 ASN B CG  1 
ATOM   617  O OD1 . ASN B 1 28 ? 4.961  -25.367 -0.508  1.00 29.50 ? 182 ASN B OD1 1 
ATOM   618  N ND2 . ASN B 1 28 ? 6.701  -26.702 -0.015  1.00 26.15 ? 182 ASN B ND2 1 
ATOM   619  N N   . TYR B 1 29 ? 7.927  -22.432 -3.644  1.00 27.38 ? 183 TYR B N   1 
ATOM   620  C CA  . TYR B 1 29 ? 8.843  -21.371 -4.088  1.00 29.12 ? 183 TYR B CA  1 
ATOM   621  C C   . TYR B 1 29 ? 8.088  -20.055 -4.185  1.00 29.02 ? 183 TYR B C   1 
ATOM   622  O O   . TYR B 1 29 ? 8.600  -19.035 -3.716  1.00 28.53 ? 183 TYR B O   1 
ATOM   623  C CB  . TYR B 1 29 ? 9.491  -21.726 -5.440  1.00 30.47 ? 183 TYR B CB  1 
ATOM   624  C CG  . TYR B 1 29 ? 10.540 -20.734 -5.909  1.00 32.57 ? 183 TYR B CG  1 
ATOM   625  C CD1 . TYR B 1 29 ? 11.857 -20.852 -5.516  1.00 33.67 ? 183 TYR B CD1 1 
ATOM   626  C CD2 . TYR B 1 29 ? 10.216 -19.708 -6.790  1.00 35.03 ? 183 TYR B CD2 1 
ATOM   627  C CE1 . TYR B 1 29 ? 12.816 -19.936 -5.929  1.00 35.25 ? 183 TYR B CE1 1 
ATOM   628  C CE2 . TYR B 1 29 ? 11.175 -18.802 -7.234  1.00 36.35 ? 183 TYR B CE2 1 
ATOM   629  C CZ  . TYR B 1 29 ? 12.477 -18.929 -6.811  1.00 36.99 ? 183 TYR B CZ  1 
ATOM   630  O OH  . TYR B 1 29 ? 13.433 -18.054 -7.281  1.00 39.19 ? 183 TYR B OH  1 
ATOM   631  N N   . ASP B 1 30 ? 6.870  -20.081 -4.743  1.00 29.07 ? 184 ASP B N   1 
ATOM   632  C CA  . ASP B 1 30 ? 6.029  -18.892 -4.862  1.00 30.51 ? 184 ASP B CA  1 
ATOM   633  C C   . ASP B 1 30 ? 5.684  -18.309 -3.484  1.00 28.71 ? 184 ASP B C   1 
ATOM   634  O O   . ASP B 1 30 ? 5.777  -17.092 -3.281  1.00 29.20 ? 184 ASP B O   1 
ATOM   635  C CB  . ASP B 1 30 ? 4.736  -19.230 -5.640  1.00 35.48 ? 184 ASP B CB  1 
ATOM   636  C CG  . ASP B 1 30 ? 3.761  -18.051 -5.760  1.00 47.03 ? 184 ASP B CG  1 
ATOM   637  O OD1 . ASP B 1 30 ? 4.144  -17.014 -6.369  1.00 50.47 ? 184 ASP B OD1 1 
ATOM   638  O OD2 . ASP B 1 30 ? 2.619  -18.160 -5.245  1.00 50.45 ? 184 ASP B OD2 1 
ATOM   639  N N   . LEU B 1 31 ? 5.312  -19.173 -2.538  1.00 26.78 ? 185 LEU B N   1 
ATOM   640  C CA  . LEU B 1 31 ? 4.956  -18.732 -1.189  1.00 26.28 ? 185 LEU B CA  1 
ATOM   641  C C   . LEU B 1 31 ? 6.181  -18.142 -0.502  1.00 24.95 ? 185 LEU B C   1 
ATOM   642  O O   . LEU B 1 31 ? 6.059  -17.115 0.151   1.00 23.87 ? 185 LEU B O   1 
ATOM   643  C CB  . LEU B 1 31 ? 4.408  -19.908 -0.352  1.00 26.29 ? 185 LEU B CB  1 
ATOM   644  C CG  . LEU B 1 31 ? 2.984  -20.340 -0.636  1.00 27.59 ? 185 LEU B CG  1 
ATOM   645  C CD1 . LEU B 1 31 ? 2.665  -21.620 0.129   1.00 27.56 ? 185 LEU B CD1 1 
ATOM   646  C CD2 . LEU B 1 31 ? 2.014  -19.256 -0.228  1.00 27.53 ? 185 LEU B CD2 1 
ATOM   647  N N   . ALA B 1 32 ? 7.365  -18.758 -0.678  1.00 24.64 ? 186 ALA B N   1 
ATOM   648  C CA  . ALA B 1 32 ? 8.601  -18.243 -0.091  1.00 25.39 ? 186 ALA B CA  1 
ATOM   649  C C   . ALA B 1 32 ? 8.938  -16.855 -0.607  1.00 25.35 ? 186 ALA B C   1 
ATOM   650  O O   . ALA B 1 32 ? 9.335  -16.010 0.182   1.00 24.90 ? 186 ALA B O   1 
ATOM   651  C CB  . ALA B 1 32 ? 9.750  -19.189 -0.351  1.00 25.00 ? 186 ALA B CB  1 
ATOM   652  N N   . MET B 1 33 ? 8.783  -16.602 -1.906  1.00 25.30 ? 187 MET B N   1 
ATOM   653  C CA  . MET B 1 33 ? 9.054  -15.282 -2.478  1.00 25.89 ? 187 MET B CA  1 
ATOM   654  C C   . MET B 1 33 ? 8.056  -14.236 -1.988  1.00 26.83 ? 187 MET B C   1 
ATOM   655  O O   . MET B 1 33 ? 8.450  -13.102 -1.683  1.00 27.83 ? 187 MET B O   1 
ATOM   656  C CB  . MET B 1 33 ? 9.053  -15.333 -4.015  1.00 27.21 ? 187 MET B CB  1 
ATOM   657  C CG  . MET B 1 33 ? 10.136 -16.218 -4.590  1.00 29.77 ? 187 MET B CG  1 
ATOM   658  S SD  . MET B 1 33 ? 11.820 -15.697 -4.130  1.00 40.14 ? 187 MET B SD  1 
ATOM   659  C CE  . MET B 1 33 ? 12.251 -16.914 -3.201  1.00 38.78 ? 187 MET B CE  1 
ATOM   660  N N   . ARG B 1 34 ? 6.774  -14.626 -1.852  1.00 25.97 ? 188 ARG B N   1 
ATOM   661  C CA  . ARG B 1 34 ? 5.772  -13.710 -1.349  1.00 25.84 ? 188 ARG B CA  1 
ATOM   662  C C   . ARG B 1 34 ? 5.999  -13.403 0.155   1.00 25.83 ? 188 ARG B C   1 
ATOM   663  O O   . ARG B 1 34 ? 5.809  -12.264 0.586   1.00 26.25 ? 188 ARG B O   1 
ATOM   664  C CB  . ARG B 1 34 ? 4.393  -14.296 -1.594  1.00 27.59 ? 188 ARG B CB  1 
ATOM   665  C CG  . ARG B 1 34 ? 4.016  -14.346 -3.087  1.00 30.23 ? 188 ARG B CG  1 
ATOM   666  C CD  . ARG B 1 34 ? 2.799  -15.234 -3.300  1.00 31.88 ? 188 ARG B CD  1 
ATOM   667  N NE  . ARG B 1 34 ? 1.662  -14.589 -2.648  1.00 35.08 ? 188 ARG B NE  1 
ATOM   668  C CZ  . ARG B 1 34 ? 0.609  -15.207 -2.117  1.00 37.18 ? 188 ARG B CZ  1 
ATOM   669  N NH1 . ARG B 1 34 ? 0.485  -16.522 -2.217  1.00 37.09 ? 188 ARG B NH1 1 
ATOM   670  N NH2 . ARG B 1 34 ? -0.334 -14.507 -1.494  1.00 35.71 ? 188 ARG B NH2 1 
ATOM   671  N N   . LEU B 1 35 ? 6.466  -14.403 0.923   1.00 24.63 ? 189 LEU B N   1 
ATOM   672  C CA  . LEU B 1 35 ? 6.759  -14.248 2.345   1.00 25.29 ? 189 LEU B CA  1 
ATOM   673  C C   . LEU B 1 35 ? 7.926  -13.294 2.511   1.00 24.89 ? 189 LEU B C   1 
ATOM   674  O O   . LEU B 1 35 ? 7.871  -12.403 3.353   1.00 24.22 ? 189 LEU B O   1 
ATOM   675  C CB  . LEU B 1 35 ? 7.074  -15.627 2.977   1.00 26.33 ? 189 LEU B CB  1 
ATOM   676  C CG  . LEU B 1 35 ? 7.526  -15.661 4.441   1.00 28.61 ? 189 LEU B CG  1 
ATOM   677  C CD1 . LEU B 1 35 ? 6.529  -14.975 5.329   1.00 29.76 ? 189 LEU B CD1 1 
ATOM   678  C CD2 . LEU B 1 35 ? 7.719  -17.096 4.897   1.00 28.74 ? 189 LEU B CD2 1 
ATOM   679  N N   . ALA B 1 36 ? 8.971  -13.469 1.678   1.00 25.75 ? 190 ALA B N   1 
ATOM   680  C CA  . ALA B 1 36 ? 10.147 -12.605 1.686   1.00 26.80 ? 190 ALA B CA  1 
ATOM   681  C C   . ALA B 1 36 ? 9.735  -11.148 1.350   1.00 27.06 ? 190 ALA B C   1 
ATOM   682  O O   . ALA B 1 36 ? 10.236 -10.212 1.956   1.00 26.61 ? 190 ALA B O   1 
ATOM   683  C CB  . ALA B 1 36 ? 11.153 -13.114 0.672   1.00 27.49 ? 190 ALA B CB  1 
ATOM   684  N N   . HIS B 1 37 ? 8.839  -10.964 0.389   1.00 27.35 ? 191 HIS B N   1 
ATOM   685  C CA  . HIS B 1 37 ? 8.347  -9.649  0.003   1.00 29.09 ? 191 HIS B CA  1 
ATOM   686  C C   . HIS B 1 37 ? 7.572  -8.962  1.127   1.00 28.80 ? 191 HIS B C   1 
ATOM   687  O O   . HIS B 1 37 ? 7.883  -7.820  1.455   1.00 29.65 ? 191 HIS B O   1 
ATOM   688  C CB  . HIS B 1 37 ? 7.510  -9.717  -1.288  1.00 31.94 ? 191 HIS B CB  1 
ATOM   689  C CG  . HIS B 1 37 ? 6.939  -8.390  -1.681  1.00 37.38 ? 191 HIS B CG  1 
ATOM   690  N ND1 . HIS B 1 37 ? 7.748  -7.375  -2.165  1.00 40.53 ? 191 HIS B ND1 1 
ATOM   691  C CD2 . HIS B 1 37 ? 5.663  -7.945  -1.628  1.00 39.53 ? 191 HIS B CD2 1 
ATOM   692  C CE1 . HIS B 1 37 ? 6.943  -6.350  -2.391  1.00 41.20 ? 191 HIS B CE1 1 
ATOM   693  N NE2 . HIS B 1 37 ? 5.677  -6.650  -2.097  1.00 41.09 ? 191 HIS B NE2 1 
ATOM   694  N N   . GLN B 1 38 ? 6.615  -9.660  1.755   1.00 27.00 ? 192 GLN B N   1 
ATOM   695  C CA  . GLN B 1 38 ? 5.828  -9.085  2.851   1.00 27.36 ? 192 GLN B CA  1 
ATOM   696  C C   . GLN B 1 38 ? 6.709  -8.713  4.056   1.00 27.50 ? 192 GLN B C   1 
ATOM   697  O O   . GLN B 1 38 ? 6.507  -7.658  4.660   1.00 27.97 ? 192 GLN B O   1 
ATOM   698  C CB  . GLN B 1 38 ? 4.711  -10.079 3.308   1.00 28.07 ? 192 GLN B CB  1 
ATOM   699  C CG  . GLN B 1 38 ? 3.600  -10.345 2.303   1.00 29.42 ? 192 GLN B CG  1 
ATOM   700  C CD  . GLN B 1 38 ? 2.780  -9.138  1.939   1.00 31.34 ? 192 GLN B CD  1 
ATOM   701  O OE1 . GLN B 1 38 ? 3.130  -8.342  1.079   1.00 33.59 ? 192 GLN B OE1 1 
ATOM   702  N NE2 . GLN B 1 38 ? 1.573  -9.046  2.503   1.00 29.76 ? 192 GLN B NE2 1 
ATOM   703  N N   . SER B 1 39 ? 7.693  -9.579  4.397   1.00 27.63 ? 193 SER B N   1 
ATOM   704  C CA  . SER B 1 39 ? 8.606  -9.302  5.507   1.00 28.79 ? 193 SER B CA  1 
ATOM   705  C C   . SER B 1 39 ? 9.449  -8.045  5.206   1.00 28.37 ? 193 SER B C   1 
ATOM   706  O O   . SER B 1 39 ? 9.708  -7.237  6.097   1.00 28.23 ? 193 SER B O   1 
ATOM   707  C CB  . SER B 1 39 ? 9.575  -10.471 5.732   1.00 32.23 ? 193 SER B CB  1 
ATOM   708  O OG  . SER B 1 39 ? 8.945  -11.690 6.061   1.00 37.70 ? 193 SER B OG  1 
ATOM   709  N N   . GLU B 1 40 ? 9.913  -7.911  3.963   1.00 28.62 ? 194 GLU B N   1 
ATOM   710  C CA  . GLU B 1 40 ? 10.729 -6.763  3.554   1.00 29.81 ? 194 GLU B CA  1 
ATOM   711  C C   . GLU B 1 40 ? 9.883  -5.498  3.645   1.00 29.78 ? 194 GLU B C   1 
ATOM   712  O O   . GLU B 1 40 ? 10.349 -4.509  4.187   1.00 28.58 ? 194 GLU B O   1 
ATOM   713  C CB  . GLU B 1 40 ? 11.251 -6.958  2.124   1.00 32.53 ? 194 GLU B CB  1 
ATOM   714  C CG  . GLU B 1 40 ? 11.852 -5.715  1.500   1.00 41.66 ? 194 GLU B CG  1 
ATOM   715  C CD  . GLU B 1 40 ? 12.508 -5.901  0.144   1.00 54.22 ? 194 GLU B CD  1 
ATOM   716  O OE1 . GLU B 1 40 ? 12.081 -6.790  -0.633  1.00 56.18 ? 194 GLU B OE1 1 
ATOM   717  O OE2 . GLU B 1 40 ? 13.472 -5.148  -0.137  1.00 59.42 ? 194 GLU B OE2 1 
ATOM   718  N N   . GLU B 1 41 ? 8.630  -5.550  3.164   1.00 29.52 ? 195 GLU B N   1 
ATOM   719  C CA  . GLU B 1 41 ? 7.721  -4.407  3.236   1.00 30.24 ? 195 GLU B CA  1 
ATOM   720  C C   . GLU B 1 41 ? 7.408  -4.010  4.663   1.00 30.17 ? 195 GLU B C   1 
ATOM   721  O O   . GLU B 1 41 ? 7.348  -2.812  4.963   1.00 31.17 ? 195 GLU B O   1 
ATOM   722  C CB  . GLU B 1 41 ? 6.442  -4.669  2.444   1.00 32.67 ? 195 GLU B CB  1 
ATOM   723  C CG  . GLU B 1 41 ? 6.655  -4.809  0.960   1.00 40.27 ? 195 GLU B CG  1 
ATOM   724  C CD  . GLU B 1 41 ? 6.971  -3.536  0.204   1.00 52.96 ? 195 GLU B CD  1 
ATOM   725  O OE1 . GLU B 1 41 ? 8.158  -3.138  0.164   1.00 55.50 ? 195 GLU B OE1 1 
ATOM   726  O OE2 . GLU B 1 41 ? 6.025  -2.943  -0.366  1.00 57.69 ? 195 GLU B OE2 1 
ATOM   727  N N   . LYS B 1 42 ? 7.230  -4.990  5.558   1.00 29.10 ? 196 LYS B N   1 
ATOM   728  C CA  . LYS B 1 42 ? 6.975  -4.692  6.960   1.00 28.48 ? 196 LYS B CA  1 
ATOM   729  C C   . LYS B 1 42 ? 8.197  -3.984  7.570   1.00 28.95 ? 196 LYS B C   1 
ATOM   730  O O   . LYS B 1 42 ? 8.060  -2.938  8.213   1.00 27.42 ? 196 LYS B O   1 
ATOM   731  C CB  . LYS B 1 42 ? 6.630  -5.976  7.745   1.00 28.74 ? 196 LYS B CB  1 
ATOM   732  C CG  . LYS B 1 42 ? 6.355  -5.693  9.209   1.00 33.01 ? 196 LYS B CG  1 
ATOM   733  C CD  . LYS B 1 42 ? 6.338  -6.947  10.023  1.00 36.39 ? 196 LYS B CD  1 
ATOM   734  C CE  . LYS B 1 42 ? 7.703  -7.305  10.569  1.00 38.63 ? 196 LYS B CE  1 
ATOM   735  N NZ  . LYS B 1 42 ? 7.826  -8.765  10.641  1.00 39.47 ? 196 LYS B NZ  1 
ATOM   736  N N   . GLY B 1 43 ? 9.381  -4.537  7.286   1.00 30.28 ? 197 GLY B N   1 
ATOM   737  C CA  . GLY B 1 43 ? 10.642 -3.974  7.759   1.00 31.47 ? 197 GLY B CA  1 
ATOM   738  C C   . GLY B 1 43 ? 10.851 -2.543  7.306   1.00 31.85 ? 197 GLY B C   1 
ATOM   739  O O   . GLY B 1 43 ? 11.245 -1.677  8.104   1.00 31.94 ? 197 GLY B O   1 
ATOM   740  N N   . ALA B 1 44 ? 10.543 -2.277  6.031   1.00 31.27 ? 198 ALA B N   1 
ATOM   741  C CA  . ALA B 1 44 ? 10.685 -0.936  5.483   1.00 31.44 ? 198 ALA B CA  1 
ATOM   742  C C   . ALA B 1 44 ? 9.742  0.049   6.179   1.00 30.92 ? 198 ALA B C   1 
ATOM   743  O O   . ALA B 1 44 ? 10.152 1.162   6.499   1.00 30.51 ? 198 ALA B O   1 
ATOM   744  C CB  . ALA B 1 44 ? 10.417 -0.950  3.985   1.00 31.82 ? 198 ALA B CB  1 
ATOM   745  N N   . ALA B 1 45 ? 8.487  -0.378  6.433   1.00 30.10 ? 199 ALA B N   1 
ATOM   746  C CA  . ALA B 1 45 ? 7.495  0.453   7.113   1.00 28.89 ? 199 ALA B CA  1 
ATOM   747  C C   . ALA B 1 45 ? 7.941  0.745   8.544   1.00 29.92 ? 199 ALA B C   1 
ATOM   748  O O   . ALA B 1 45 ? 7.799  1.882   8.991   1.00 30.25 ? 199 ALA B O   1 
ATOM   749  C CB  . ALA B 1 45 ? 6.150  -0.247  7.124   1.00 28.00 ? 199 ALA B CB  1 
ATOM   750  N N   . LEU B 1 46 ? 8.516  -0.244  9.261   1.00 30.10 ? 200 LEU B N   1 
ATOM   751  C CA  . LEU B 1 46 ? 8.973  -0.012  10.635  1.00 30.99 ? 200 LEU B CA  1 
ATOM   752  C C   . LEU B 1 46 ? 10.118 1.008   10.693  1.00 32.04 ? 200 LEU B C   1 
ATOM   753  O O   . LEU B 1 46 ? 10.158 1.817   11.625  1.00 32.85 ? 200 LEU B O   1 
ATOM   754  C CB  . LEU B 1 46 ? 9.396  -1.329  11.307  1.00 30.93 ? 200 LEU B CB  1 
ATOM   755  C CG  . LEU B 1 46 ? 8.284  -2.306  11.581  1.00 32.19 ? 200 LEU B CG  1 
ATOM   756  C CD1 . LEU B 1 46 ? 8.840  -3.651  11.991  1.00 33.52 ? 200 LEU B CD1 1 
ATOM   757  C CD2 . LEU B 1 46 ? 7.311  -1.755  12.601  1.00 32.33 ? 200 LEU B CD2 1 
ATOM   758  N N   . MET B 1 47 ? 10.984 1.007   9.682   1.00 32.53 ? 201 MET B N   1 
ATOM   759  C CA  . MET B 1 47 ? 12.106 1.953   9.611   1.00 33.77 ? 201 MET B CA  1 
ATOM   760  C C   . MET B 1 47 ? 11.578 3.376   9.327   1.00 33.26 ? 201 MET B C   1 
ATOM   761  O O   . MET B 1 47 ? 11.992 4.334   10.005  1.00 32.49 ? 201 MET B O   1 
ATOM   762  C CB  . MET B 1 47 ? 13.133 1.466   8.576   1.00 35.89 ? 201 MET B CB  1 
ATOM   763  C CG  . MET B 1 47 ? 13.927 0.262   9.127   1.00 40.81 ? 201 MET B CG  1 
ATOM   764  S SD  . MET B 1 47 ? 15.359 -0.395  8.226   1.00 53.41 ? 201 MET B SD  1 
ATOM   765  C CE  . MET B 1 47 ? 14.677 -0.603  6.610   1.00 50.28 ? 201 MET B CE  1 
ATOM   766  N N   . ARG B 1 48 ? 10.592 3.502   8.414   1.00 31.94 ? 202 ARG B N   1 
ATOM   767  C CA  . ARG B 1 48 ? 9.985  4.803   8.148   1.00 31.54 ? 202 ARG B CA  1 
ATOM   768  C C   . ARG B 1 48 ? 9.273  5.327   9.383   1.00 31.72 ? 202 ARG B C   1 
ATOM   769  O O   . ARG B 1 48 ? 9.354  6.521   9.673   1.00 32.01 ? 202 ARG B O   1 
ATOM   770  C CB  . ARG B 1 48 ? 9.022  4.747   6.955   1.00 32.18 ? 202 ARG B CB  1 
ATOM   771  C CG  . ARG B 1 48 ? 9.742  4.433   5.632   1.00 34.90 ? 202 ARG B CG  1 
ATOM   772  C CD  . ARG B 1 48 ? 8.881  4.678   4.400   1.00 38.20 ? 202 ARG B CD  1 
ATOM   773  N NE  . ARG B 1 48 ? 7.612  3.947   4.399   1.00 40.62 ? 202 ARG B NE  1 
ATOM   774  C CZ  . ARG B 1 48 ? 7.449  2.720   3.904   1.00 42.64 ? 202 ARG B CZ  1 
ATOM   775  N NH1 . ARG B 1 48 ? 8.484  2.054   3.402   1.00 42.61 ? 202 ARG B NH1 1 
ATOM   776  N NH2 . ARG B 1 48 ? 6.257  2.130   3.950   1.00 41.21 ? 202 ARG B NH2 1 
ATOM   777  N N   . ASN B 1 49 ? 8.622  4.434   10.144  1.00 30.68 ? 203 ASN B N   1 
ATOM   778  C CA  . ASN B 1 49 ? 7.936  4.787   11.382  1.00 30.76 ? 203 ASN B CA  1 
ATOM   779  C C   . ASN B 1 49 ? 8.889  5.414   12.385  1.00 31.45 ? 203 ASN B C   1 
ATOM   780  O O   . ASN B 1 49 ? 8.552  6.422   13.023  1.00 31.14 ? 203 ASN B O   1 
ATOM   781  C CB  . ASN B 1 49 ? 7.233  3.552   12.000  1.00 30.59 ? 203 ASN B CB  1 
ATOM   782  C CG  . ASN B 1 49 ? 6.017  3.097   11.223  1.00 31.78 ? 203 ASN B CG  1 
ATOM   783  O OD1 . ASN B 1 49 ? 5.399  2.058   11.532  1.00 32.06 ? 203 ASN B OD1 1 
ATOM   784  N ND2 . ASN B 1 49 ? 5.696  3.831   10.160  1.00 30.11 ? 203 ASN B ND2 1 
ATOM   785  N N   . ARG B 1 50 ? 10.077 4.827   12.521  1.00 32.65 ? 204 ARG B N   1 
ATOM   786  C CA  . ARG B 1 50 ? 11.080 5.331   13.450  1.00 33.28 ? 204 ARG B CA  1 
ATOM   787  C C   . ARG B 1 50 ? 11.513 6.759   13.052  1.00 32.67 ? 204 ARG B C   1 
ATOM   788  O O   . ARG B 1 50 ? 11.550 7.651   13.905  1.00 33.19 ? 204 ARG B O   1 
ATOM   789  C CB  . ARG B 1 50 ? 12.279 4.358   13.457  1.00 35.49 ? 204 ARG B CB  1 
ATOM   790  C CG  . ARG B 1 50 ? 13.500 4.841   14.216  1.00 41.87 ? 204 ARG B CG  1 
ATOM   791  C CD  . ARG B 1 50 ? 14.722 4.106   13.683  1.00 49.07 ? 204 ARG B CD  1 
ATOM   792  N NE  . ARG B 1 50 ? 15.045 4.548   12.325  1.00 55.52 ? 204 ARG B NE  1 
ATOM   793  C CZ  . ARG B 1 50 ? 15.851 3.906   11.491  1.00 60.47 ? 204 ARG B CZ  1 
ATOM   794  N NH1 . ARG B 1 50 ? 16.446 2.780   11.864  1.00 60.84 ? 204 ARG B NH1 1 
ATOM   795  N NH2 . ARG B 1 50 ? 16.105 4.409   10.290  1.00 61.67 ? 204 ARG B NH2 1 
ATOM   796  N N   . ASP B 1 51 ? 11.772 6.966   11.760  1.00 31.88 ? 205 ASP B N   1 
ATOM   797  C CA  . ASP B 1 51 ? 12.177 8.262   11.206  1.00 32.53 ? 205 ASP B CA  1 
ATOM   798  C C   . ASP B 1 51 ? 11.088 9.319   11.372  1.00 32.30 ? 205 ASP B C   1 
ATOM   799  O O   . ASP B 1 51 ? 11.385 10.468  11.693  1.00 31.33 ? 205 ASP B O   1 
ATOM   800  C CB  . ASP B 1 51 ? 12.536 8.125   9.716   1.00 35.05 ? 205 ASP B CB  1 
ATOM   801  C CG  . ASP B 1 51 ? 13.804 7.348   9.443   1.00 40.77 ? 205 ASP B CG  1 
ATOM   802  O OD1 . ASP B 1 51 ? 14.594 7.151   10.390  1.00 42.77 ? 205 ASP B OD1 1 
ATOM   803  O OD2 . ASP B 1 51 ? 14.001 6.929   8.287   1.00 43.67 ? 205 ASP B OD2 1 
ATOM   804  N N   . LEU B 1 52 ? 9.823  8.938   11.149  1.00 31.78 ? 206 LEU B N   1 
ATOM   805  C CA  . LEU B 1 52 ? 8.698  9.850   11.307  1.00 31.28 ? 206 LEU B CA  1 
ATOM   806  C C   . LEU B 1 52 ? 8.535  10.245  12.767  1.00 31.08 ? 206 LEU B C   1 
ATOM   807  O O   . LEU B 1 52 ? 8.293  11.423  13.046  1.00 30.40 ? 206 LEU B O   1 
ATOM   808  C CB  . LEU B 1 52 ? 7.391  9.224   10.787  1.00 31.49 ? 206 LEU B CB  1 
ATOM   809  C CG  . LEU B 1 52 ? 7.305  9.008   9.272   1.00 33.78 ? 206 LEU B CG  1 
ATOM   810  C CD1 . LEU B 1 52 ? 6.015  8.310   8.896   1.00 34.73 ? 206 LEU B CD1 1 
ATOM   811  C CD2 . LEU B 1 52 ? 7.419  10.294  8.509   1.00 34.75 ? 206 LEU B CD2 1 
ATOM   812  N N   . GLN B 1 53 ? 8.700  9.285   13.707  1.00 30.93 ? 207 GLN B N   1 
ATOM   813  C CA  . GLN B 1 53 ? 8.581  9.601   15.123  1.00 31.43 ? 207 GLN B CA  1 
ATOM   814  C C   . GLN B 1 53 ? 9.650  10.603  15.557  1.00 31.65 ? 207 GLN B C   1 
ATOM   815  O O   . GLN B 1 53 ? 9.363  11.519  16.325  1.00 31.24 ? 207 GLN B O   1 
ATOM   816  C CB  . GLN B 1 53 ? 8.632  8.338   15.984  1.00 33.59 ? 207 GLN B CB  1 
ATOM   817  C CG  . GLN B 1 53 ? 8.306  8.605   17.460  1.00 36.22 ? 207 GLN B CG  1 
ATOM   818  C CD  . GLN B 1 53 ? 6.940  9.218   17.679  1.00 41.03 ? 207 GLN B CD  1 
ATOM   819  O OE1 . GLN B 1 53 ? 5.915  8.613   17.388  1.00 42.95 ? 207 GLN B OE1 1 
ATOM   820  N NE2 . GLN B 1 53 ? 6.892  10.438  18.219  1.00 41.25 ? 207 GLN B NE2 1 
ATOM   821  N N   . LEU B 1 54 ? 10.862 10.444  15.043  1.00 32.92 ? 208 LEU B N   1 
ATOM   822  C CA  . LEU B 1 54 ? 11.960 11.368  15.332  1.00 35.22 ? 208 LEU B CA  1 
ATOM   823  C C   . LEU B 1 54 ? 11.641 12.797  14.832  1.00 36.46 ? 208 LEU B C   1 
ATOM   824  O O   . LEU B 1 54 ? 11.965 13.771  15.516  1.00 37.08 ? 208 LEU B O   1 
ATOM   825  C CB  . LEU B 1 54 ? 13.227 10.851  14.655  1.00 36.29 ? 208 LEU B CB  1 
ATOM   826  C CG  . LEU B 1 54 ? 14.285 10.111  15.487  1.00 40.41 ? 208 LEU B CG  1 
ATOM   827  C CD1 . LEU B 1 54 ? 13.698 9.314   16.672  1.00 41.92 ? 208 LEU B CD1 1 
ATOM   828  C CD2 . LEU B 1 54 ? 15.116 9.197   14.598  1.00 41.42 ? 208 LEU B CD2 1 
ATOM   829  N N   . GLU B 1 55 ? 11.012 12.911  13.646  1.00 36.83 ? 209 GLU B N   1 
ATOM   830  C CA  . GLU B 1 55 ? 10.620 14.192  13.055  1.00 37.24 ? 209 GLU B CA  1 
ATOM   831  C C   . GLU B 1 55 ? 9.585  14.881  13.922  1.00 37.28 ? 209 GLU B C   1 
ATOM   832  O O   . GLU B 1 55 ? 9.700  16.083  14.156  1.00 37.27 ? 209 GLU B O   1 
ATOM   833  C CB  . GLU B 1 55 ? 10.032 13.986  11.649  1.00 39.76 ? 209 GLU B CB  1 
ATOM   834  C CG  . GLU B 1 55 ? 11.044 13.735  10.548  1.00 47.08 ? 209 GLU B CG  1 
ATOM   835  C CD  . GLU B 1 55 ? 10.403 13.692  9.172   1.00 55.70 ? 209 GLU B CD  1 
ATOM   836  O OE1 . GLU B 1 55 ? 9.605  14.604  8.855   1.00 56.19 ? 209 GLU B OE1 1 
ATOM   837  O OE2 . GLU B 1 55 ? 10.693 12.741  8.411   1.00 59.18 ? 209 GLU B OE2 1 
ATOM   838  N N   . ILE B 1 56 ? 8.552  14.124  14.378  1.00 36.66 ? 210 ILE B N   1 
ATOM   839  C CA  . ILE B 1 56 ? 7.466  14.619  15.219  1.00 37.64 ? 210 ILE B CA  1 
ATOM   840  C C   . ILE B 1 56 ? 7.984  15.180  16.537  1.00 39.17 ? 210 ILE B C   1 
ATOM   841  O O   . ILE B 1 56 ? 7.539  16.246  16.967  1.00 39.46 ? 210 ILE B O   1 
ATOM   842  C CB  . ILE B 1 56 ? 6.442  13.487  15.461  1.00 37.58 ? 210 ILE B CB  1 
ATOM   843  C CG1 . ILE B 1 56 ? 5.668  13.220  14.176  1.00 38.47 ? 210 ILE B CG1 1 
ATOM   844  C CG2 . ILE B 1 56 ? 5.477  13.807  16.614  1.00 38.15 ? 210 ILE B CG2 1 
ATOM   845  C CD1 . ILE B 1 56 ? 4.878  11.954  14.222  1.00 39.95 ? 210 ILE B CD1 1 
ATOM   846  N N   . ASP B 1 57 ? 8.905  14.454  17.170  1.00 39.57 ? 211 ASP B N   1 
ATOM   847  C CA  . ASP B 1 57 ? 9.489  14.839  18.449  1.00 41.38 ? 211 ASP B CA  1 
ATOM   848  C C   . ASP B 1 57 ? 10.208 16.200  18.361  1.00 43.47 ? 211 ASP B C   1 
ATOM   849  O O   . ASP B 1 57 ? 10.251 16.935  19.342  1.00 44.05 ? 211 ASP B O   1 
ATOM   850  C CB  . ASP B 1 57 ? 10.433 13.728  18.947  1.00 42.99 ? 211 ASP B CB  1 
ATOM   851  C CG  . ASP B 1 57 ? 9.728  12.464  19.406  1.00 47.99 ? 211 ASP B CG  1 
ATOM   852  O OD1 . ASP B 1 57 ? 10.418 11.450  19.623  1.00 49.77 ? 211 ASP B OD1 1 
ATOM   853  O OD2 . ASP B 1 57 ? 8.483  12.493  19.550  1.00 49.66 ? 211 ASP B OD2 1 
ATOM   854  N N   . GLN B 1 58 ? 10.741 16.546  17.186  1.00 44.45 ? 212 GLN B N   1 
ATOM   855  C CA  . GLN B 1 58 ? 11.424 17.826  16.972  1.00 46.03 ? 212 GLN B CA  1 
ATOM   856  C C   . GLN B 1 58 ? 10.420 18.985  16.745  1.00 47.19 ? 212 GLN B C   1 
ATOM   857  O O   . GLN B 1 58 ? 10.720 20.142  17.051  1.00 47.49 ? 212 GLN B O   1 
ATOM   858  C CB  . GLN B 1 58 ? 12.405 17.704  15.784  1.00 48.28 ? 212 GLN B CB  1 
ATOM   859  C CG  . GLN B 1 58 ? 13.552 16.728  16.039  1.00 53.83 ? 212 GLN B CG  1 
ATOM   860  C CD  . GLN B 1 58 ? 14.272 16.200  14.807  1.00 62.03 ? 212 GLN B CD  1 
ATOM   861  O OE1 . GLN B 1 58 ? 15.148 15.322  14.907  1.00 65.04 ? 212 GLN B OE1 1 
ATOM   862  N NE2 . GLN B 1 58 ? 13.929 16.694  13.614  1.00 63.24 ? 212 GLN B NE2 1 
ATOM   863  N N   . LEU B 1 59 ? 9.228  18.681  16.229  1.00 47.60 ? 213 LEU B N   1 
ATOM   864  C CA  . LEU B 1 59 ? 8.235  19.702  15.916  1.00 48.57 ? 213 LEU B CA  1 
ATOM   865  C C   . LEU B 1 59 ? 7.280  20.059  17.052  1.00 49.88 ? 213 LEU B C   1 
ATOM   866  O O   . LEU B 1 59 ? 6.801  21.201  17.076  1.00 49.88 ? 213 LEU B O   1 
ATOM   867  C CB  . LEU B 1 59 ? 7.412  19.297  14.682  1.00 48.60 ? 213 LEU B CB  1 
ATOM   868  C CG  . LEU B 1 59 ? 8.172  19.037  13.405  1.00 50.55 ? 213 LEU B CG  1 
ATOM   869  C CD1 . LEU B 1 59 ? 7.252  18.440  12.351  1.00 51.70 ? 213 LEU B CD1 1 
ATOM   870  C CD2 . LEU B 1 59 ? 8.863  20.298  12.902  1.00 51.17 ? 213 LEU B CD2 1 
ATOM   871  N N   . LYS B 1 60 ? 6.893  19.098  17.906  1.00 50.60 ? 214 LYS B N   1 
ATOM   872  C CA  . LYS B 1 60 ? 5.903  19.386  18.951  1.00 52.06 ? 214 LYS B CA  1 
ATOM   873  C C   . LYS B 1 60 ? 6.492  20.186  20.120  1.00 52.84 ? 214 LYS B C   1 
ATOM   874  O O   . LYS B 1 60 ? 7.693  20.112  20.362  1.00 53.35 ? 214 LYS B O   1 
ATOM   875  C CB  . LYS B 1 60 ? 5.173  18.107  19.423  1.00 54.81 ? 214 LYS B CB  1 
ATOM   876  C CG  . LYS B 1 60 ? 5.779  17.381  20.628  1.00 60.36 ? 214 LYS B CG  1 
ATOM   877  C CD  . LYS B 1 60 ? 6.998  16.548  20.265  1.00 65.54 ? 214 LYS B CD  1 
ATOM   878  C CE  . LYS B 1 60 ? 7.860  16.273  21.477  1.00 69.76 ? 214 LYS B CE  1 
ATOM   879  N NZ  . LYS B 1 60 ? 8.702  17.449  21.825  1.00 71.98 ? 214 LYS B NZ  1 
ATOM   880  N N   . ALA C 1 1  ? 5.600  -39.594 -42.723 1.00 48.26 ? 155 ALA C N   1 
ATOM   881  C CA  . ALA C 1 1  ? 6.992  -39.455 -42.293 1.00 48.25 ? 155 ALA C CA  1 
ATOM   882  C C   . ALA C 1 1  ? 7.091  -38.718 -40.968 1.00 47.64 ? 155 ALA C C   1 
ATOM   883  O O   . ALA C 1 1  ? 6.975  -37.487 -40.933 1.00 48.82 ? 155 ALA C O   1 
ATOM   884  C CB  . ALA C 1 1  ? 7.789  -38.721 -43.350 1.00 48.75 ? 155 ALA C CB  1 
ATOM   885  N N   . LYS C 1 2  ? 7.343  -39.457 -39.875 1.00 45.16 ? 156 LYS C N   1 
ATOM   886  C CA  . LYS C 1 2  ? 7.394  -38.843 -38.567 1.00 41.83 ? 156 LYS C CA  1 
ATOM   887  C C   . LYS C 1 2  ? 8.785  -38.665 -38.004 1.00 37.60 ? 156 LYS C C   1 
ATOM   888  O O   . LYS C 1 2  ? 8.903  -37.852 -37.114 1.00 35.84 ? 156 LYS C O   1 
ATOM   889  C CB  . LYS C 1 2  ? 6.506  -39.577 -37.560 1.00 43.72 ? 156 LYS C CB  1 
ATOM   890  C CG  . LYS C 1 2  ? 5.785  -38.636 -36.608 1.00 49.19 ? 156 LYS C CG  1 
ATOM   891  C CD  . LYS C 1 2  ? 4.711  -39.343 -35.822 1.00 54.53 ? 156 LYS C CD  1 
ATOM   892  C CE  . LYS C 1 2  ? 5.298  -40.020 -34.624 1.00 59.31 ? 156 LYS C CE  1 
ATOM   893  N NZ  . LYS C 1 2  ? 4.413  -41.100 -34.113 1.00 61.94 ? 156 LYS C NZ  1 
ATOM   894  N N   . HIS C 1 3  ? 9.849  -39.356 -38.505 1.00 35.84 ? 157 HIS C N   1 
ATOM   895  C CA  . HIS C 1 3  ? 11.191 -39.191 -37.920 1.00 34.21 ? 157 HIS C CA  1 
ATOM   896  C C   . HIS C 1 3  ? 11.627 -37.715 -37.822 1.00 32.59 ? 157 HIS C C   1 
ATOM   897  O O   . HIS C 1 3  ? 12.023 -37.291 -36.746 1.00 32.16 ? 157 HIS C O   1 
ATOM   898  C CB  . HIS C 1 3  ? 12.266 -40.044 -38.621 1.00 34.10 ? 157 HIS C CB  1 
ATOM   899  C CG  . HIS C 1 3  ? 13.668 -39.719 -38.186 1.00 34.49 ? 157 HIS C CG  1 
ATOM   900  N ND1 . HIS C 1 3  ? 14.136 -40.062 -36.923 1.00 35.76 ? 157 HIS C ND1 1 
ATOM   901  C CD2 . HIS C 1 3  ? 14.645 -39.060 -38.850 1.00 34.99 ? 157 HIS C CD2 1 
ATOM   902  C CE1 . HIS C 1 3  ? 15.383 -39.623 -36.869 1.00 35.82 ? 157 HIS C CE1 1 
ATOM   903  N NE2 . HIS C 1 3  ? 15.732 -39.009 -38.005 1.00 35.80 ? 157 HIS C NE2 1 
ATOM   904  N N   . GLN C 1 4  ? 11.496 -36.936 -38.909 1.00 32.30 ? 158 GLN C N   1 
ATOM   905  C CA  . GLN C 1 4  ? 11.883 -35.520 -38.873 1.00 33.03 ? 158 GLN C CA  1 
ATOM   906  C C   . GLN C 1 4  ? 11.075 -34.694 -37.855 1.00 33.34 ? 158 GLN C C   1 
ATOM   907  O O   . GLN C 1 4  ? 11.583 -33.716 -37.285 1.00 32.95 ? 158 GLN C O   1 
ATOM   908  C CB  . GLN C 1 4  ? 11.783 -34.879 -40.269 1.00 34.91 ? 158 GLN C CB  1 
ATOM   909  C CG  . GLN C 1 4  ? 13.003 -35.136 -41.143 1.00 40.97 ? 158 GLN C CG  1 
ATOM   910  C CD  . GLN C 1 4  ? 12.751 -34.794 -42.594 1.00 46.34 ? 158 GLN C CD  1 
ATOM   911  O OE1 . GLN C 1 4  ? 11.806 -35.286 -43.220 1.00 49.02 ? 158 GLN C OE1 1 
ATOM   912  N NE2 . GLN C 1 4  ? 13.596 -33.948 -43.161 1.00 45.20 ? 158 GLN C NE2 1 
ATOM   913  N N   . GLU C 1 5  ? 9.803  -35.064 -37.660 1.00 33.46 ? 159 GLU C N   1 
ATOM   914  C CA  . GLU C 1 5  ? 8.939  -34.349 -36.727 1.00 33.92 ? 159 GLU C CA  1 
ATOM   915  C C   . GLU C 1 5  ? 9.286  -34.714 -35.279 1.00 34.05 ? 159 GLU C C   1 
ATOM   916  O O   . GLU C 1 5  ? 9.233  -33.835 -34.407 1.00 34.92 ? 159 GLU C O   1 
ATOM   917  C CB  . GLU C 1 5  ? 7.452  -34.562 -37.058 1.00 36.91 ? 159 GLU C CB  1 
ATOM   918  C CG  . GLU C 1 5  ? 6.996  -33.721 -38.247 1.00 41.47 ? 159 GLU C CG  1 
ATOM   919  C CD  . GLU C 1 5  ? 7.758  -33.977 -39.538 1.00 45.98 ? 159 GLU C CD  1 
ATOM   920  O OE1 . GLU C 1 5  ? 8.308  -33.013 -40.121 1.00 43.67 ? 159 GLU C OE1 1 
ATOM   921  O OE2 . GLU C 1 5  ? 7.849  -35.161 -39.936 1.00 49.36 ? 159 GLU C OE2 1 
ATOM   922  N N   . ARG C 1 6  ? 9.681  -35.981 -35.029 1.00 32.90 ? 160 ARG C N   1 
ATOM   923  C CA  . ARG C 1 6  ? 10.119 -36.431 -33.707 1.00 33.71 ? 160 ARG C CA  1 
ATOM   924  C C   . ARG C 1 6  ? 11.418 -35.690 -33.367 1.00 33.06 ? 160 ARG C C   1 
ATOM   925  O O   . ARG C 1 6  ? 11.557 -35.182 -32.271 1.00 33.91 ? 160 ARG C O   1 
ATOM   926  C CB  . ARG C 1 6  ? 10.368 -37.955 -33.681 1.00 36.41 ? 160 ARG C CB  1 
ATOM   927  C CG  . ARG C 1 6  ? 9.145  -38.825 -34.010 1.00 40.24 ? 160 ARG C CG  1 
ATOM   928  C CD  . ARG C 1 6  ? 9.514  -40.310 -34.086 1.00 44.26 ? 160 ARG C CD  1 
ATOM   929  N NE  . ARG C 1 6  ? 8.350  -41.151 -34.401 1.00 48.57 ? 160 ARG C NE  1 
ATOM   930  C CZ  . ARG C 1 6  ? 7.972  -42.211 -33.688 1.00 52.01 ? 160 ARG C CZ  1 
ATOM   931  N NH1 . ARG C 1 6  ? 8.667  -42.585 -32.620 1.00 51.96 ? 160 ARG C NH1 1 
ATOM   932  N NH2 . ARG C 1 6  ? 6.893  -42.901 -34.036 1.00 52.61 ? 160 ARG C NH2 1 
ATOM   933  N N   . VAL C 1 7  ? 12.349 -35.584 -34.324 1.00 32.44 ? 161 VAL C N   1 
ATOM   934  C CA  . VAL C 1 7  ? 13.607 -34.859 -34.136 1.00 32.09 ? 161 VAL C CA  1 
ATOM   935  C C   . VAL C 1 7  ? 13.331 -33.372 -33.797 1.00 31.87 ? 161 VAL C C   1 
ATOM   936  O O   . VAL C 1 7  ? 13.917 -32.816 -32.851 1.00 31.40 ? 161 VAL C O   1 
ATOM   937  C CB  . VAL C 1 7  ? 14.538 -34.999 -35.369 1.00 33.27 ? 161 VAL C CB  1 
ATOM   938  C CG1 . VAL C 1 7  ? 15.754 -34.076 -35.233 1.00 33.70 ? 161 VAL C CG1 1 
ATOM   939  C CG2 . VAL C 1 7  ? 14.996 -36.439 -35.545 1.00 34.71 ? 161 VAL C CG2 1 
ATOM   940  N N   . GLN C 1 8  ? 12.433 -32.739 -34.548 1.00 31.50 ? 162 GLN C N   1 
ATOM   941  C CA  . GLN C 1 8  ? 12.053 -31.361 -34.300 1.00 31.77 ? 162 GLN C CA  1 
ATOM   942  C C   . GLN C 1 8  ? 11.444 -31.123 -32.899 1.00 32.71 ? 162 GLN C C   1 
ATOM   943  O O   . GLN C 1 8  ? 11.820 -30.140 -32.251 1.00 32.04 ? 162 GLN C O   1 
ATOM   944  C CB  . GLN C 1 8  ? 11.135 -30.843 -35.410 1.00 31.05 ? 162 GLN C CB  1 
ATOM   945  C CG  . GLN C 1 8  ? 10.781 -29.347 -35.313 1.00 33.40 ? 162 GLN C CG  1 
ATOM   946  C CD  . GLN C 1 8  ? 11.938 -28.373 -35.119 1.00 35.21 ? 162 GLN C CD  1 
ATOM   947  O OE1 . GLN C 1 8  ? 13.051 -28.538 -35.631 1.00 36.45 ? 162 GLN C OE1 1 
ATOM   948  N NE2 . GLN C 1 8  ? 11.689 -27.296 -34.396 1.00 33.27 ? 162 GLN C NE2 1 
ATOM   949  N N   . ARG C 1 9  ? 10.547 -32.017 -32.414 1.00 34.02 ? 163 ARG C N   1 
ATOM   950  C CA  . ARG C 1 9  ? 9.961  -31.821 -31.083 1.00 36.19 ? 163 ARG C CA  1 
ATOM   951  C C   . ARG C 1 9  ? 11.003 -32.011 -29.972 1.00 36.30 ? 163 ARG C C   1 
ATOM   952  O O   . ARG C 1 9  ? 10.961 -31.294 -28.978 1.00 36.61 ? 163 ARG C O   1 
ATOM   953  C CB  . ARG C 1 9  ? 8.694  -32.663 -30.862 1.00 40.48 ? 163 ARG C CB  1 
ATOM   954  C CG  . ARG C 1 9  ? 8.866  -34.145 -31.127 1.00 47.98 ? 163 ARG C CG  1 
ATOM   955  C CD  . ARG C 1 9  ? 9.004  -34.964 -29.852 1.00 54.73 ? 163 ARG C CD  1 
ATOM   956  N NE  . ARG C 1 9  ? 9.466  -36.321 -30.144 1.00 59.55 ? 163 ARG C NE  1 
ATOM   957  C CZ  . ARG C 1 9  ? 9.170  -37.388 -29.408 1.00 63.95 ? 163 ARG C CZ  1 
ATOM   958  N NH1 . ARG C 1 9  ? 8.423  -37.264 -28.314 1.00 63.59 ? 163 ARG C NH1 1 
ATOM   959  N NH2 . ARG C 1 9  ? 9.621  -38.588 -29.757 1.00 64.93 ? 163 ARG C NH2 1 
ATOM   960  N N   . LEU C 1 10 ? 11.984 -32.902 -30.183 1.00 36.14 ? 164 LEU C N   1 
ATOM   961  C CA  . LEU C 1 10 ? 13.073 -33.103 -29.227 1.00 36.43 ? 164 LEU C CA  1 
ATOM   962  C C   . LEU C 1 10 ? 13.972 -31.847 -29.164 1.00 36.11 ? 164 LEU C C   1 
ATOM   963  O O   . LEU C 1 10 ? 14.426 -31.451 -28.084 1.00 36.37 ? 164 LEU C O   1 
ATOM   964  C CB  . LEU C 1 10 ? 13.880 -34.344 -29.633 1.00 37.85 ? 164 LEU C CB  1 
ATOM   965  C CG  . LEU C 1 10 ? 13.664 -35.671 -28.843 1.00 40.01 ? 164 LEU C CG  1 
ATOM   966  C CD1 . LEU C 1 10 ? 12.269 -35.781 -28.185 1.00 40.47 ? 164 LEU C CD1 1 
ATOM   967  C CD2 . LEU C 1 10 ? 13.939 -36.879 -29.741 1.00 41.45 ? 164 LEU C CD2 1 
ATOM   968  N N   . LYS C 1 11 ? 14.184 -31.210 -30.318 1.00 34.77 ? 165 LYS C N   1 
ATOM   969  C CA  . LYS C 1 11 ? 14.953 -29.981 -30.458 1.00 34.40 ? 165 LYS C CA  1 
ATOM   970  C C   . LYS C 1 11 ? 14.248 -28.841 -29.724 1.00 34.88 ? 165 LYS C C   1 
ATOM   971  O O   . LYS C 1 11 ? 14.897 -28.129 -28.950 1.00 34.63 ? 165 LYS C O   1 
ATOM   972  C CB  . LYS C 1 11 ? 15.156 -29.650 -31.938 1.00 34.39 ? 165 LYS C CB  1 
ATOM   973  C CG  . LYS C 1 11 ? 15.873 -28.326 -32.178 1.00 35.63 ? 165 LYS C CG  1 
ATOM   974  C CD  . LYS C 1 11 ? 16.337 -28.203 -33.603 1.00 37.34 ? 165 LYS C CD  1 
ATOM   975  C CE  . LYS C 1 11 ? 17.208 -26.986 -33.795 1.00 40.33 ? 165 LYS C CE  1 
ATOM   976  N NZ  . LYS C 1 11 ? 16.400 -25.727 -33.868 1.00 41.29 ? 165 LYS C NZ  1 
ATOM   977  N N   . GLU C 1 12 ? 12.923 -28.723 -29.877 1.00 34.57 ? 166 GLU C N   1 
ATOM   978  C CA  . GLU C 1 12 ? 12.144 -27.700 -29.169 1.00 36.00 ? 166 GLU C CA  1 
ATOM   979  C C   . GLU C 1 12 ? 12.157 -27.916 -27.645 1.00 37.52 ? 166 GLU C C   1 
ATOM   980  O O   . GLU C 1 12 ? 12.180 -26.940 -26.887 1.00 37.40 ? 166 GLU C O   1 
ATOM   981  C CB  . GLU C 1 12 ? 10.700 -27.686 -29.679 1.00 37.40 ? 166 GLU C CB  1 
ATOM   982  C CG  . GLU C 1 12 ? 10.583 -26.999 -31.020 1.00 40.55 ? 166 GLU C CG  1 
ATOM   983  C CD  . GLU C 1 12 ? 9.398  -27.412 -31.865 1.00 45.57 ? 166 GLU C CD  1 
ATOM   984  O OE1 . GLU C 1 12 ? 9.350  -26.992 -33.042 1.00 47.00 ? 166 GLU C OE1 1 
ATOM   985  O OE2 . GLU C 1 12 ? 8.528  -28.161 -31.364 1.00 48.29 ? 166 GLU C OE2 1 
ATOM   986  N N   . GLU C 1 13 ? 12.082 -29.184 -27.196 1.00 38.22 ? 167 GLU C N   1 
ATOM   987  C CA  . GLU C 1 13 ? 12.101 -29.513 -25.764 1.00 39.44 ? 167 GLU C CA  1 
ATOM   988  C C   . GLU C 1 13 ? 13.450 -29.165 -25.126 1.00 38.69 ? 167 GLU C C   1 
ATOM   989  O O   . GLU C 1 13 ? 13.503 -28.666 -24.001 1.00 39.06 ? 167 GLU C O   1 
ATOM   990  C CB  . GLU C 1 13 ? 11.774 -31.000 -25.571 1.00 43.62 ? 167 GLU C CB  1 
ATOM   991  C CG  . GLU C 1 13 ? 10.380 -31.242 -25.016 1.00 52.59 ? 167 GLU C CG  1 
ATOM   992  C CD  . GLU C 1 13 ? 9.240  -30.523 -25.716 1.00 65.00 ? 167 GLU C CD  1 
ATOM   993  O OE1 . GLU C 1 13 ? 8.531  -29.741 -25.039 1.00 67.47 ? 167 GLU C OE1 1 
ATOM   994  O OE2 . GLU C 1 13 ? 9.059  -30.735 -26.939 1.00 69.18 ? 167 GLU C OE2 1 
ATOM   995  N N   . CYS C 1 14 ? 14.532 -29.408 -25.866 1.00 37.86 ? 168 CYS C N   1 
ATOM   996  C CA  . CYS C 1 14 ? 15.905 -29.114 -25.483 1.00 38.14 ? 168 CYS C CA  1 
ATOM   997  C C   . CYS C 1 14 ? 16.106 -27.604 -25.399 1.00 36.66 ? 168 CYS C C   1 
ATOM   998  O O   . CYS C 1 14 ? 16.729 -27.117 -24.452 1.00 35.59 ? 168 CYS C O   1 
ATOM   999  C CB  . CYS C 1 14 ? 16.865 -29.746 -26.485 1.00 40.78 ? 168 CYS C CB  1 
ATOM   1000 S SG  . CYS C 1 14 ? 18.623 -29.508 -26.109 1.00 53.10 ? 168 CYS C SG  1 
ATOM   1001 N N   . GLU C 1 15 ? 15.559 -26.861 -26.380 1.00 35.82 ? 169 GLU C N   1 
ATOM   1002 C CA  . GLU C 1 15 ? 15.663 -25.411 -26.404 1.00 35.84 ? 169 GLU C CA  1 
ATOM   1003 C C   . GLU C 1 15 ? 14.937 -24.793 -25.224 1.00 35.38 ? 169 GLU C C   1 
ATOM   1004 O O   . GLU C 1 15 ? 15.434 -23.820 -24.666 1.00 35.61 ? 169 GLU C O   1 
ATOM   1005 C CB  . GLU C 1 15 ? 15.117 -24.837 -27.722 1.00 37.34 ? 169 GLU C CB  1 
ATOM   1006 C CG  . GLU C 1 15 ? 16.093 -25.011 -28.868 1.00 39.16 ? 169 GLU C CG  1 
ATOM   1007 C CD  . GLU C 1 15 ? 15.503 -24.810 -30.250 1.00 40.72 ? 169 GLU C CD  1 
ATOM   1008 O OE1 . GLU C 1 15 ? 14.274 -24.591 -30.357 1.00 40.03 ? 169 GLU C OE1 1 
ATOM   1009 O OE2 . GLU C 1 15 ? 16.280 -24.868 -31.228 1.00 41.04 ? 169 GLU C OE2 1 
ATOM   1010 N N   . ALA C 1 16 ? 13.787 -25.350 -24.846 1.00 35.08 ? 170 ALA C N   1 
ATOM   1011 C CA  . ALA C 1 16 ? 12.999 -24.883 -23.709 1.00 35.90 ? 170 ALA C CA  1 
ATOM   1012 C C   . ALA C 1 16 ? 13.773 -25.074 -22.387 1.00 36.58 ? 170 ALA C C   1 
ATOM   1013 O O   . ALA C 1 16 ? 13.812 -24.158 -21.551 1.00 36.63 ? 170 ALA C O   1 
ATOM   1014 C CB  . ALA C 1 16 ? 11.669 -25.620 -23.666 1.00 36.15 ? 170 ALA C CB  1 
ATOM   1015 N N   . GLY C 1 17 ? 14.419 -26.235 -22.257 1.00 36.56 ? 171 GLY C N   1 
ATOM   1016 C CA  . GLY C 1 17 ? 15.226 -26.585 -21.096 1.00 36.49 ? 171 GLY C CA  1 
ATOM   1017 C C   . GLY C 1 17 ? 16.438 -25.686 -20.962 1.00 36.14 ? 171 GLY C C   1 
ATOM   1018 O O   . GLY C 1 17 ? 16.740 -25.230 -19.859 1.00 34.85 ? 171 GLY C O   1 
ATOM   1019 N N   . SER C 1 18 ? 17.132 -25.388 -22.087 1.00 35.91 ? 172 SER C N   1 
ATOM   1020 C CA  . SER C 1 18 ? 18.287 -24.495 -22.016 1.00 36.65 ? 172 SER C CA  1 
ATOM   1021 C C   . SER C 1 18 ? 17.865 -23.057 -21.633 1.00 36.06 ? 172 SER C C   1 
ATOM   1022 O O   . SER C 1 18 ? 18.564 -22.423 -20.845 1.00 35.84 ? 172 SER C O   1 
ATOM   1023 C CB  . SER C 1 18 ? 19.108 -24.549 -23.305 1.00 39.77 ? 172 SER C CB  1 
ATOM   1024 O OG  . SER C 1 18 ? 18.334 -24.129 -24.415 1.00 44.14 ? 172 SER C OG  1 
ATOM   1025 N N   . ARG C 1 19 ? 16.687 -22.578 -22.088 1.00 35.10 ? 173 ARG C N   1 
ATOM   1026 C CA  . ARG C 1 19 ? 16.202 -21.249 -21.703 1.00 35.39 ? 173 ARG C CA  1 
ATOM   1027 C C   . ARG C 1 19 ? 15.880 -21.233 -20.208 1.00 34.12 ? 173 ARG C C   1 
ATOM   1028 O O   . ARG C 1 19 ? 16.227 -20.271 -19.525 1.00 33.22 ? 173 ARG C O   1 
ATOM   1029 C CB  . ARG C 1 19 ? 14.959 -20.834 -22.522 1.00 37.52 ? 173 ARG C CB  1 
ATOM   1030 C CG  . ARG C 1 19 ? 15.292 -20.437 -23.945 1.00 43.26 ? 173 ARG C CG  1 
ATOM   1031 C CD  . ARG C 1 19 ? 14.090 -19.846 -24.641 1.00 47.68 ? 173 ARG C CD  1 
ATOM   1032 N NE  . ARG C 1 19 ? 13.409 -20.848 -25.455 1.00 51.43 ? 173 ARG C NE  1 
ATOM   1033 C CZ  . ARG C 1 19 ? 12.309 -21.488 -25.085 1.00 53.63 ? 173 ARG C CZ  1 
ATOM   1034 N NH1 . ARG C 1 19 ? 11.731 -21.211 -23.921 1.00 54.45 ? 173 ARG C NH1 1 
ATOM   1035 N NH2 . ARG C 1 19 ? 11.762 -22.390 -25.882 1.00 53.16 ? 173 ARG C NH2 1 
ATOM   1036 N N   . GLU C 1 20 ? 15.230 -22.297 -19.711 1.00 33.62 ? 174 GLU C N   1 
ATOM   1037 C CA  . GLU C 1 20 ? 14.889 -22.412 -18.301 1.00 33.93 ? 174 GLU C CA  1 
ATOM   1038 C C   . GLU C 1 20 ? 16.149 -22.506 -17.439 1.00 32.95 ? 174 GLU C C   1 
ATOM   1039 O O   . GLU C 1 20 ? 16.182 -21.903 -16.371 1.00 33.33 ? 174 GLU C O   1 
ATOM   1040 C CB  . GLU C 1 20 ? 13.965 -23.612 -18.046 1.00 37.26 ? 174 GLU C CB  1 
ATOM   1041 C CG  . GLU C 1 20 ? 13.410 -23.627 -16.635 1.00 44.16 ? 174 GLU C CG  1 
ATOM   1042 C CD  . GLU C 1 20 ? 12.329 -24.656 -16.359 1.00 52.49 ? 174 GLU C CD  1 
ATOM   1043 O OE1 . GLU C 1 20 ? 12.166 -25.605 -17.162 1.00 53.28 ? 174 GLU C OE1 1 
ATOM   1044 O OE2 . GLU C 1 20 ? 11.638 -24.507 -15.326 1.00 54.77 ? 174 GLU C OE2 1 
ATOM   1045 N N   . LEU C 1 21 ? 17.197 -23.189 -17.922 1.00 31.96 ? 175 LEU C N   1 
ATOM   1046 C CA  . LEU C 1 21 ? 18.454 -23.299 -17.169 1.00 32.75 ? 175 LEU C CA  1 
ATOM   1047 C C   . LEU C 1 21 ? 19.145 -21.935 -17.053 1.00 33.69 ? 175 LEU C C   1 
ATOM   1048 O O   . LEU C 1 21 ? 19.618 -21.561 -15.977 1.00 32.71 ? 175 LEU C O   1 
ATOM   1049 C CB  . LEU C 1 21 ? 19.386 -24.326 -17.822 1.00 32.72 ? 175 LEU C CB  1 
ATOM   1050 C CG  . LEU C 1 21 ? 20.769 -24.471 -17.181 1.00 33.68 ? 175 LEU C CG  1 
ATOM   1051 C CD1 . LEU C 1 21 ? 20.667 -24.926 -15.720 1.00 33.32 ? 175 LEU C CD1 1 
ATOM   1052 C CD2 . LEU C 1 21 ? 21.652 -25.386 -18.021 1.00 34.25 ? 175 LEU C CD2 1 
ATOM   1053 N N   . LYS C 1 22 ? 19.143 -21.163 -18.153 1.00 34.41 ? 176 LYS C N   1 
ATOM   1054 C CA  . LYS C 1 22 ? 19.716 -19.821 -18.169 1.00 35.30 ? 176 LYS C CA  1 
ATOM   1055 C C   . LYS C 1 22 ? 19.015 -18.920 -17.131 1.00 35.12 ? 176 LYS C C   1 
ATOM   1056 O O   . LYS C 1 22 ? 19.672 -18.201 -16.377 1.00 35.19 ? 176 LYS C O   1 
ATOM   1057 C CB  . LYS C 1 22 ? 19.596 -19.226 -19.593 1.00 38.52 ? 176 LYS C CB  1 
ATOM   1058 C CG  . LYS C 1 22 ? 19.965 -17.744 -19.689 1.00 45.02 ? 176 LYS C CG  1 
ATOM   1059 C CD  . LYS C 1 22 ? 19.961 -17.233 -21.119 1.00 51.51 ? 176 LYS C CD  1 
ATOM   1060 C CE  . LYS C 1 22 ? 20.340 -15.766 -21.197 1.00 55.93 ? 176 LYS C CE  1 
ATOM   1061 N NZ  . LYS C 1 22 ? 21.706 -15.494 -20.661 1.00 58.21 ? 176 LYS C NZ  1 
ATOM   1062 N N   . ARG C 1 23 ? 17.695 -19.012 -17.074 1.00 35.08 ? 177 ARG C N   1 
ATOM   1063 C CA  . ARG C 1 23 ? 16.843 -18.266 -16.152 1.00 36.08 ? 177 ARG C CA  1 
ATOM   1064 C C   . ARG C 1 23 ? 17.116 -18.679 -14.714 1.00 34.36 ? 177 ARG C C   1 
ATOM   1065 O O   . ARG C 1 23 ? 17.232 -17.823 -13.841 1.00 33.64 ? 177 ARG C O   1 
ATOM   1066 C CB  . ARG C 1 23 ? 15.374 -18.564 -16.472 1.00 39.68 ? 177 ARG C CB  1 
ATOM   1067 C CG  . ARG C 1 23 ? 14.423 -17.458 -16.076 1.00 47.17 ? 177 ARG C CG  1 
ATOM   1068 C CD  . ARG C 1 23 ? 13.084 -17.518 -16.811 1.00 53.71 ? 177 ARG C CD  1 
ATOM   1069 N NE  . ARG C 1 23 ? 13.174 -17.977 -18.202 1.00 59.65 ? 177 ARG C NE  1 
ATOM   1070 C CZ  . ARG C 1 23 ? 13.567 -17.230 -19.231 1.00 63.48 ? 177 ARG C CZ  1 
ATOM   1071 N NH1 . ARG C 1 23 ? 13.904 -15.958 -19.047 1.00 63.79 ? 177 ARG C NH1 1 
ATOM   1072 N NH2 . ARG C 1 23 ? 13.638 -17.753 -20.450 1.00 63.73 ? 177 ARG C NH2 1 
ATOM   1073 N N   . CYS C 1 24 ? 17.219 -19.981 -14.467 1.00 33.73 ? 178 CYS C N   1 
ATOM   1074 C CA  . CYS C 1 24 ? 17.472 -20.533 -13.140 1.00 33.44 ? 178 CYS C CA  1 
ATOM   1075 C C   . CYS C 1 24 ? 18.828 -20.085 -12.591 1.00 32.69 ? 178 CYS C C   1 
ATOM   1076 O O   . CYS C 1 24 ? 18.915 -19.699 -11.428 1.00 32.11 ? 178 CYS C O   1 
ATOM   1077 C CB  . CYS C 1 24 ? 17.351 -22.052 -13.184 1.00 34.32 ? 178 CYS C CB  1 
ATOM   1078 S SG  . CYS C 1 24 ? 17.349 -22.859 -11.561 1.00 35.89 ? 178 CYS C SG  1 
ATOM   1079 N N   . LYS C 1 25 ? 19.879 -20.096 -13.427 1.00 32.46 ? 179 LYS C N   1 
ATOM   1080 C CA  . LYS C 1 25 ? 21.209 -19.678 -12.979 1.00 33.25 ? 179 LYS C CA  1 
ATOM   1081 C C   . LYS C 1 25 ? 21.237 -18.196 -12.616 1.00 33.84 ? 179 LYS C C   1 
ATOM   1082 O O   . LYS C 1 25 ? 21.846 -17.827 -11.603 1.00 33.57 ? 179 LYS C O   1 
ATOM   1083 C CB  . LYS C 1 25 ? 22.252 -19.998 -14.058 1.00 35.01 ? 179 LYS C CB  1 
ATOM   1084 C CG  . LYS C 1 25 ? 22.561 -21.475 -14.202 1.00 40.02 ? 179 LYS C CG  1 
ATOM   1085 C CD  . LYS C 1 25 ? 23.600 -21.627 -15.299 1.00 47.29 ? 179 LYS C CD  1 
ATOM   1086 C CE  . LYS C 1 25 ? 24.126 -23.023 -15.465 1.00 53.13 ? 179 LYS C CE  1 
ATOM   1087 N NZ  . LYS C 1 25 ? 24.938 -23.130 -16.712 1.00 57.36 ? 179 LYS C NZ  1 
ATOM   1088 N N   . GLU C 1 26 ? 20.546 -17.359 -13.407 1.00 34.48 ? 180 GLU C N   1 
ATOM   1089 C CA  . GLU C 1 26 ? 20.437 -15.922 -13.144 1.00 36.18 ? 180 GLU C CA  1 
ATOM   1090 C C   . GLU C 1 26 ? 19.701 -15.678 -11.835 1.00 36.37 ? 180 GLU C C   1 
ATOM   1091 O O   . GLU C 1 26 ? 20.116 -14.817 -11.068 1.00 36.99 ? 180 GLU C O   1 
ATOM   1092 C CB  . GLU C 1 26 ? 19.688 -15.201 -14.273 1.00 40.06 ? 180 GLU C CB  1 
ATOM   1093 C CG  . GLU C 1 26 ? 20.514 -15.039 -15.531 1.00 49.50 ? 180 GLU C CG  1 
ATOM   1094 C CD  . GLU C 1 26 ? 19.734 -14.616 -16.762 1.00 60.67 ? 180 GLU C CD  1 
ATOM   1095 O OE1 . GLU C 1 26 ? 18.485 -14.529 -16.689 1.00 62.66 ? 180 GLU C OE1 1 
ATOM   1096 O OE2 . GLU C 1 26 ? 20.381 -14.379 -17.810 1.00 65.93 ? 180 GLU C OE2 1 
ATOM   1097 N N   . GLU C 1 27 ? 18.605 -16.418 -11.596 1.00 35.57 ? 181 GLU C N   1 
ATOM   1098 C CA  . GLU C 1 27 ? 17.810 -16.321 -10.377 1.00 35.09 ? 181 GLU C CA  1 
ATOM   1099 C C   . GLU C 1 27 ? 18.624 -16.756 -9.185  1.00 34.00 ? 181 GLU C C   1 
ATOM   1100 O O   . GLU C 1 27 ? 18.482 -16.146 -8.128  1.00 34.60 ? 181 GLU C O   1 
ATOM   1101 C CB  . GLU C 1 27 ? 16.548 -17.188 -10.451 1.00 37.32 ? 181 GLU C CB  1 
ATOM   1102 C CG  . GLU C 1 27 ? 15.446 -16.563 -11.280 1.00 44.61 ? 181 GLU C CG  1 
ATOM   1103 C CD  . GLU C 1 27 ? 14.240 -17.445 -11.553 1.00 54.17 ? 181 GLU C CD  1 
ATOM   1104 O OE1 . GLU C 1 27 ? 14.121 -18.528 -10.935 1.00 56.61 ? 181 GLU C OE1 1 
ATOM   1105 O OE2 . GLU C 1 27 ? 13.389 -17.035 -12.376 1.00 57.47 ? 181 GLU C OE2 1 
ATOM   1106 N N   . ASN C 1 28 ? 19.451 -17.793 -9.330  1.00 31.79 ? 182 ASN C N   1 
ATOM   1107 C CA  . ASN C 1 28 ? 20.258 -18.297 -8.236  1.00 31.88 ? 182 ASN C CA  1 
ATOM   1108 C C   . ASN C 1 28 ? 21.294 -17.246 -7.788  1.00 32.38 ? 182 ASN C C   1 
ATOM   1109 O O   . ASN C 1 28 ? 21.496 -17.032 -6.592  1.00 31.38 ? 182 ASN C O   1 
ATOM   1110 C CB  . ASN C 1 28 ? 20.862 -19.663 -8.624  1.00 33.01 ? 182 ASN C CB  1 
ATOM   1111 C CG  . ASN C 1 28 ? 19.835 -20.813 -8.418  1.00 36.44 ? 182 ASN C CG  1 
ATOM   1112 O OD1 . ASN C 1 28 ? 18.669 -20.592 -8.064  1.00 35.91 ? 182 ASN C OD1 1 
ATOM   1113 N ND2 . ASN C 1 28 ? 20.215 -22.052 -8.646  1.00 37.92 ? 182 ASN C ND2 1 
ATOM   1114 N N   . TYR C 1 29 ? 21.892 -16.539 -8.761  1.00 33.24 ? 183 TYR C N   1 
ATOM   1115 C CA  . TYR C 1 29 ? 22.856 -15.487 -8.442  1.00 35.08 ? 183 TYR C CA  1 
ATOM   1116 C C   . TYR C 1 29 ? 22.159 -14.325 -7.719  1.00 33.98 ? 183 TYR C C   1 
ATOM   1117 O O   . TYR C 1 29 ? 22.676 -13.822 -6.729  1.00 34.05 ? 183 TYR C O   1 
ATOM   1118 C CB  . TYR C 1 29 ? 23.560 -14.997 -9.721  1.00 37.51 ? 183 TYR C CB  1 
ATOM   1119 C CG  . TYR C 1 29 ? 24.714 -14.052 -9.437  1.00 40.81 ? 183 TYR C CG  1 
ATOM   1120 C CD1 . TYR C 1 29 ? 25.954 -14.536 -9.039  1.00 42.87 ? 183 TYR C CD1 1 
ATOM   1121 C CD2 . TYR C 1 29 ? 24.555 -12.679 -9.539  1.00 42.91 ? 183 TYR C CD2 1 
ATOM   1122 C CE1 . TYR C 1 29 ? 27.012 -13.675 -8.765  1.00 44.52 ? 183 TYR C CE1 1 
ATOM   1123 C CE2 . TYR C 1 29 ? 25.610 -11.810 -9.283  1.00 44.43 ? 183 TYR C CE2 1 
ATOM   1124 C CZ  . TYR C 1 29 ? 26.836 -12.312 -8.886  1.00 45.88 ? 183 TYR C CZ  1 
ATOM   1125 O OH  . TYR C 1 29 ? 27.898 -11.465 -8.638  1.00 48.66 ? 183 TYR C OH  1 
ATOM   1126 N N   . ASP C 1 30 ? 20.963 -13.944 -8.188  1.00 33.14 ? 184 ASP C N   1 
ATOM   1127 C CA  . ASP C 1 30 ? 20.142 -12.887 -7.585  1.00 33.13 ? 184 ASP C CA  1 
ATOM   1128 C C   . ASP C 1 30 ? 19.748 -13.253 -6.144  1.00 31.26 ? 184 ASP C C   1 
ATOM   1129 O O   . ASP C 1 30 ? 19.838 -12.410 -5.262  1.00 31.15 ? 184 ASP C O   1 
ATOM   1130 C CB  . ASP C 1 30 ? 18.875 -12.634 -8.418  1.00 36.90 ? 184 ASP C CB  1 
ATOM   1131 C CG  . ASP C 1 30 ? 17.916 -11.595 -7.853  1.00 44.55 ? 184 ASP C CG  1 
ATOM   1132 O OD1 . ASP C 1 30 ? 18.321 -10.422 -7.732  1.00 45.70 ? 184 ASP C OD1 1 
ATOM   1133 O OD2 . ASP C 1 30 ? 16.741 -11.960 -7.554  1.00 48.53 ? 184 ASP C OD2 1 
ATOM   1134 N N   . LEU C 1 31 ? 19.342 -14.500 -5.902  1.00 29.11 ? 185 LEU C N   1 
ATOM   1135 C CA  . LEU C 1 31 ? 18.957 -14.940 -4.565  1.00 28.05 ? 185 LEU C CA  1 
ATOM   1136 C C   . LEU C 1 31 ? 20.160 -14.887 -3.622  1.00 27.35 ? 185 LEU C C   1 
ATOM   1137 O O   . LEU C 1 31 ? 20.019 -14.446 -2.480  1.00 26.84 ? 185 LEU C O   1 
ATOM   1138 C CB  . LEU C 1 31 ? 18.374 -16.356 -4.591  1.00 27.41 ? 185 LEU C CB  1 
ATOM   1139 C CG  . LEU C 1 31 ? 16.947 -16.475 -5.134  1.00 28.66 ? 185 LEU C CG  1 
ATOM   1140 C CD1 . LEU C 1 31 ? 16.581 -17.917 -5.307  1.00 29.11 ? 185 LEU C CD1 1 
ATOM   1141 C CD2 . LEU C 1 31 ? 15.952 -15.775 -4.234  1.00 28.49 ? 185 LEU C CD2 1 
ATOM   1142 N N   . ALA C 1 32 ? 21.338 -15.307 -4.099  1.00 26.81 ? 186 ALA C N   1 
ATOM   1143 C CA  . ALA C 1 32 ? 22.539 -15.269 -3.271  1.00 28.14 ? 186 ALA C CA  1 
ATOM   1144 C C   . ALA C 1 32 ? 22.890 -13.821 -2.856  1.00 28.92 ? 186 ALA C C   1 
ATOM   1145 O O   . ALA C 1 32 ? 23.243 -13.574 -1.699  1.00 28.84 ? 186 ALA C O   1 
ATOM   1146 C CB  . ALA C 1 32 ? 23.699 -15.925 -4.014  1.00 29.27 ? 186 ALA C CB  1 
ATOM   1147 N N   . MET C 1 33 ? 22.759 -12.859 -3.789  1.00 29.38 ? 187 MET C N   1 
ATOM   1148 C CA  . MET C 1 33 ? 23.050 -11.449 -3.494  1.00 30.16 ? 187 MET C CA  1 
ATOM   1149 C C   . MET C 1 33 ? 22.008 -10.861 -2.534  1.00 29.26 ? 187 MET C C   1 
ATOM   1150 O O   . MET C 1 33 ? 22.359 -10.098 -1.637  1.00 28.58 ? 187 MET C O   1 
ATOM   1151 C CB  . MET C 1 33 ? 23.106 -10.612 -4.798  1.00 32.32 ? 187 MET C CB  1 
ATOM   1152 C CG  . MET C 1 33 ? 24.234 -11.048 -5.757  1.00 36.79 ? 187 MET C CG  1 
ATOM   1153 S SD  . MET C 1 33 ? 25.894 -10.993 -4.996  1.00 47.38 ? 187 MET C SD  1 
ATOM   1154 C CE  . MET C 1 33 ? 26.277 -12.681 -4.899  1.00 46.77 ? 187 MET C CE  1 
ATOM   1155 N N   . ARG C 1 34 ? 20.737 -11.252 -2.691  1.00 28.04 ? 188 ARG C N   1 
ATOM   1156 C CA  . ARG C 1 34 ? 19.676 -10.796 -1.789  1.00 27.93 ? 188 ARG C CA  1 
ATOM   1157 C C   . ARG C 1 34 ? 19.865 -11.366 -0.372  1.00 27.29 ? 188 ARG C C   1 
ATOM   1158 O O   . ARG C 1 34 ? 19.611 -10.664 0.616   1.00 26.75 ? 188 ARG C O   1 
ATOM   1159 C CB  . ARG C 1 34 ? 18.294 -11.116 -2.354  1.00 29.16 ? 188 ARG C CB  1 
ATOM   1160 C CG  . ARG C 1 34 ? 17.995 -10.229 -3.555  1.00 31.06 ? 188 ARG C CG  1 
ATOM   1161 C CD  . ARG C 1 34 ? 16.904 -10.813 -4.365  1.00 34.35 ? 188 ARG C CD  1 
ATOM   1162 N NE  . ARG C 1 34 ? 15.619 -10.765 -3.682  1.00 37.09 ? 188 ARG C NE  1 
ATOM   1163 C CZ  . ARG C 1 34 ? 14.526 -11.379 -4.121  1.00 42.14 ? 188 ARG C CZ  1 
ATOM   1164 N NH1 . ARG C 1 34 ? 14.581 -12.172 -5.192  1.00 43.60 ? 188 ARG C NH1 1 
ATOM   1165 N NH2 . ARG C 1 34 ? 13.375 -11.223 -3.487  1.00 41.73 ? 188 ARG C NH2 1 
ATOM   1166 N N   . LEU C 1 35 ? 20.347 -12.603 -0.273  1.00 27.07 ? 189 LEU C N   1 
ATOM   1167 C CA  . LEU C 1 35 ? 20.618 -13.239 1.012   1.00 28.79 ? 189 LEU C CA  1 
ATOM   1168 C C   . LEU C 1 35 ? 21.768 -12.508 1.768   1.00 28.76 ? 189 LEU C C   1 
ATOM   1169 O O   . LEU C 1 35 ? 21.663 -12.210 2.956   1.00 28.56 ? 189 LEU C O   1 
ATOM   1170 C CB  . LEU C 1 35 ? 20.939 -14.723 0.789   1.00 30.33 ? 189 LEU C CB  1 
ATOM   1171 C CG  . LEU C 1 35 ? 21.143 -15.564 2.039   1.00 34.38 ? 189 LEU C CG  1 
ATOM   1172 C CD1 . LEU C 1 35 ? 19.846 -15.646 2.865   1.00 35.01 ? 189 LEU C CD1 1 
ATOM   1173 C CD2 . LEU C 1 35 ? 21.544 -17.004 1.668   1.00 35.29 ? 189 LEU C CD2 1 
ATOM   1174 N N   . ALA C 1 36 ? 22.827 -12.168 1.050   1.00 28.86 ? 190 ALA C N   1 
ATOM   1175 C CA  . ALA C 1 36 ? 23.953 -11.418 1.621   1.00 28.80 ? 190 ALA C CA  1 
ATOM   1176 C C   . ALA C 1 36 ? 23.496 -10.007 2.031   1.00 29.62 ? 190 ALA C C   1 
ATOM   1177 O O   . ALA C 1 36 ? 23.888 -9.541  3.095   1.00 29.51 ? 190 ALA C O   1 
ATOM   1178 C CB  . ALA C 1 36 ? 25.075 -11.330 0.615   1.00 28.66 ? 190 ALA C CB  1 
ATOM   1179 N N   . HIS C 1 37 ? 22.623 -9.344  1.232   1.00 30.24 ? 191 HIS C N   1 
ATOM   1180 C CA  . HIS C 1 37 ? 22.093 -8.019  1.572   1.00 31.50 ? 191 HIS C CA  1 
ATOM   1181 C C   . HIS C 1 37 ? 21.248 -8.057  2.851   1.00 30.62 ? 191 HIS C C   1 
ATOM   1182 O O   . HIS C 1 37 ? 21.418 -7.205  3.727   1.00 30.86 ? 191 HIS C O   1 
ATOM   1183 C CB  . HIS C 1 37 ? 21.292 -7.426  0.405   1.00 35.35 ? 191 HIS C CB  1 
ATOM   1184 C CG  . HIS C 1 37 ? 20.595 -6.143  0.734   1.00 41.68 ? 191 HIS C CG  1 
ATOM   1185 N ND1 . HIS C 1 37 ? 21.300 -4.965  0.934   1.00 44.64 ? 191 HIS C ND1 1 
ATOM   1186 C CD2 . HIS C 1 37 ? 19.276 -5.893  0.894   1.00 44.07 ? 191 HIS C CD2 1 
ATOM   1187 C CE1 . HIS C 1 37 ? 20.391 -4.043  1.195   1.00 45.37 ? 191 HIS C CE1 1 
ATOM   1188 N NE2 . HIS C 1 37 ? 19.157 -4.555  1.188   1.00 45.31 ? 191 HIS C NE2 1 
ATOM   1189 N N   . GLN C 1 38 ? 20.356 -9.054  2.988   1.00 28.74 ? 192 GLN C N   1 
ATOM   1190 C CA  . GLN C 1 38 ? 19.554 -9.202  4.183   1.00 28.02 ? 192 GLN C CA  1 
ATOM   1191 C C   . GLN C 1 38 ? 20.457 -9.464  5.408   1.00 25.30 ? 192 GLN C C   1 
ATOM   1192 O O   . GLN C 1 38 ? 20.141 -8.944  6.460   1.00 24.18 ? 192 GLN C O   1 
ATOM   1193 C CB  . GLN C 1 38 ? 18.518 -10.328 4.038   1.00 30.28 ? 192 GLN C CB  1 
ATOM   1194 C CG  . GLN C 1 38 ? 17.366 -10.060 3.046   1.00 36.42 ? 192 GLN C CG  1 
ATOM   1195 C CD  . GLN C 1 38 ? 16.567 -8.839  3.426   1.00 43.83 ? 192 GLN C CD  1 
ATOM   1196 O OE1 . GLN C 1 38 ? 16.446 -7.851  2.659   1.00 46.03 ? 192 GLN C OE1 1 
ATOM   1197 N NE2 . GLN C 1 38 ? 16.054 -8.876  4.642   1.00 42.76 ? 192 GLN C NE2 1 
ATOM   1198 N N   . SER C 1 39 ? 21.571 -10.217 5.268   1.00 24.70 ? 193 SER C N   1 
ATOM   1199 C CA  . SER C 1 39 ? 22.470 -10.453 6.411   1.00 23.82 ? 193 SER C CA  1 
ATOM   1200 C C   . SER C 1 39 ? 23.125 -9.123  6.863   1.00 23.37 ? 193 SER C C   1 
ATOM   1201 O O   . SER C 1 39 ? 23.257 -8.875  8.058   1.00 22.79 ? 193 SER C O   1 
ATOM   1202 C CB  . SER C 1 39 ? 23.561 -11.454 6.053   1.00 26.58 ? 193 SER C CB  1 
ATOM   1203 O OG  . SER C 1 39 ? 22.990 -12.743 5.915   1.00 31.82 ? 193 SER C OG  1 
ATOM   1204 N N   . GLU C 1 40 ? 23.550 -8.296  5.912   1.00 23.19 ? 194 GLU C N   1 
ATOM   1205 C CA  . GLU C 1 40 ? 24.134 -6.990  6.234   1.00 22.86 ? 194 GLU C CA  1 
ATOM   1206 C C   . GLU C 1 40 ? 23.098 -6.096  6.951   1.00 22.73 ? 194 GLU C C   1 
ATOM   1207 O O   . GLU C 1 40 ? 23.389 -5.468  7.970   1.00 22.43 ? 194 GLU C O   1 
ATOM   1208 C CB  . GLU C 1 40 ? 24.648 -6.307  4.968   1.00 24.84 ? 194 GLU C CB  1 
ATOM   1209 C CG  . GLU C 1 40 ? 25.866 -6.963  4.317   1.00 28.91 ? 194 GLU C CG  1 
ATOM   1210 C CD  . GLU C 1 40 ? 26.309 -6.275  3.041   1.00 35.56 ? 194 GLU C CD  1 
ATOM   1211 O OE1 . GLU C 1 40 ? 26.912 -6.947  2.171   1.00 34.05 ? 194 GLU C OE1 1 
ATOM   1212 O OE2 . GLU C 1 40 ? 26.071 -5.051  2.921   1.00 39.77 ? 194 GLU C OE2 1 
ATOM   1213 N N   . GLU C 1 41 ? 21.871 -6.066  6.425   1.00 23.24 ? 195 GLU C N   1 
ATOM   1214 C CA  . GLU C 1 41 ? 20.795 -5.292  7.037   1.00 23.78 ? 195 GLU C CA  1 
ATOM   1215 C C   . GLU C 1 41 ? 20.424 -5.816  8.420   1.00 24.17 ? 195 GLU C C   1 
ATOM   1216 O O   . GLU C 1 41 ? 20.087 -5.021  9.303   1.00 24.35 ? 195 GLU C O   1 
ATOM   1217 C CB  . GLU C 1 41 ? 19.552 -5.291  6.123   1.00 25.75 ? 195 GLU C CB  1 
ATOM   1218 C CG  . GLU C 1 41 ? 19.767 -4.567  4.828   1.00 33.50 ? 195 GLU C CG  1 
ATOM   1219 C CD  . GLU C 1 41 ? 18.617 -3.638  4.503   1.00 51.00 ? 195 GLU C CD  1 
ATOM   1220 O OE1 . GLU C 1 41 ? 17.563 -4.149  4.056   1.00 55.09 ? 195 GLU C OE1 1 
ATOM   1221 O OE2 . GLU C 1 41 ? 18.782 -2.402  4.643   1.00 55.39 ? 195 GLU C OE2 1 
ATOM   1222 N N   . LYS C 1 42 ? 20.449 -7.140  8.608   1.00 23.52 ? 196 LYS C N   1 
ATOM   1223 C CA  . LYS C 1 42 ? 20.131 -7.761  9.901   1.00 23.91 ? 196 LYS C CA  1 
ATOM   1224 C C   . LYS C 1 42 ? 21.243 -7.398  10.896  1.00 23.91 ? 196 LYS C C   1 
ATOM   1225 O O   . LYS C 1 42 ? 20.955 -7.016  12.013  1.00 23.26 ? 196 LYS C O   1 
ATOM   1226 C CB  . LYS C 1 42 ? 20.022 -9.271  9.811   1.00 26.63 ? 196 LYS C CB  1 
ATOM   1227 C CG  . LYS C 1 42 ? 19.528 -9.861  11.106  1.00 32.36 ? 196 LYS C CG  1 
ATOM   1228 C CD  . LYS C 1 42 ? 19.423 -11.325 11.005  1.00 37.89 ? 196 LYS C CD  1 
ATOM   1229 C CE  . LYS C 1 42 ? 20.692 -11.981 11.439  1.00 41.11 ? 196 LYS C CE  1 
ATOM   1230 N NZ  . LYS C 1 42 ? 20.569 -13.447 11.271  1.00 43.25 ? 196 LYS C NZ  1 
ATOM   1231 N N   . GLY C 1 43 ? 22.496 -7.454  10.457  1.00 23.49 ? 197 GLY C N   1 
ATOM   1232 C CA  . GLY C 1 43 ? 23.636 -7.037  11.264  1.00 24.17 ? 197 GLY C CA  1 
ATOM   1233 C C   . GLY C 1 43 ? 23.511 -5.598  11.741  1.00 24.99 ? 197 GLY C C   1 
ATOM   1234 O O   . GLY C 1 43 ? 23.762 -5.312  12.914  1.00 25.26 ? 197 GLY C O   1 
ATOM   1235 N N   . ALA C 1 44 ? 23.083 -4.698  10.844  1.00 24.39 ? 198 ALA C N   1 
ATOM   1236 C CA  . ALA C 1 44 ? 22.875 -3.295  11.209  1.00 24.73 ? 198 ALA C CA  1 
ATOM   1237 C C   . ALA C 1 44 ? 21.726 -3.153  12.249  1.00 24.70 ? 198 ALA C C   1 
ATOM   1238 O O   . ALA C 1 44 ? 21.865 -2.423  13.230  1.00 25.03 ? 198 ALA C O   1 
ATOM   1239 C CB  . ALA C 1 44 ? 22.574 -2.476  9.953   1.00 25.11 ? 198 ALA C CB  1 
ATOM   1240 N N   . ALA C 1 45 ? 20.628 -3.894  12.073  1.00 24.69 ? 199 ALA C N   1 
ATOM   1241 C CA  . ALA C 1 45 ? 19.501 -3.864  13.026  1.00 25.20 ? 199 ALA C CA  1 
ATOM   1242 C C   . ALA C 1 45 ? 19.917 -4.394  14.401  1.00 26.42 ? 199 ALA C C   1 
ATOM   1243 O O   . ALA C 1 45 ? 19.496 -3.855  15.426  1.00 27.95 ? 199 ALA C O   1 
ATOM   1244 C CB  . ALA C 1 45 ? 18.343 -4.695  12.498  1.00 24.72 ? 199 ALA C CB  1 
ATOM   1245 N N   . LEU C 1 46 ? 20.754 -5.444  14.443  1.00 26.32 ? 200 LEU C N   1 
ATOM   1246 C CA  . LEU C 1 46 ? 21.217 -6.014  15.713  1.00 25.96 ? 200 LEU C CA  1 
ATOM   1247 C C   . LEU C 1 46 ? 22.133 -5.050  16.433  1.00 27.18 ? 200 LEU C C   1 
ATOM   1248 O O   . LEU C 1 46 ? 22.107 -5.030  17.656  1.00 28.39 ? 200 LEU C O   1 
ATOM   1249 C CB  . LEU C 1 46 ? 21.918 -7.362  15.506  1.00 25.94 ? 200 LEU C CB  1 
ATOM   1250 C CG  . LEU C 1 46 ? 20.964 -8.486  15.065  1.00 27.21 ? 200 LEU C CG  1 
ATOM   1251 C CD1 . LEU C 1 46 ? 21.755 -9.716  14.666  1.00 27.75 ? 200 LEU C CD1 1 
ATOM   1252 C CD2 . LEU C 1 46 ? 19.893 -8.779  16.126  1.00 28.08 ? 200 LEU C CD2 1 
ATOM   1253 N N   . MET C 1 47 ? 22.915 -4.235  15.700  1.00 27.61 ? 201 MET C N   1 
ATOM   1254 C CA  . MET C 1 47 ? 23.771 -3.225  16.308  1.00 28.84 ? 201 MET C CA  1 
ATOM   1255 C C   . MET C 1 47 ? 22.869 -2.137  16.942  1.00 29.14 ? 201 MET C C   1 
ATOM   1256 O O   . MET C 1 47 ? 23.094 -1.723  18.076  1.00 29.71 ? 201 MET C O   1 
ATOM   1257 C CB  . MET C 1 47 ? 24.682 -2.584  15.264  1.00 30.11 ? 201 MET C CB  1 
ATOM   1258 C CG  . MET C 1 47 ? 25.578 -1.572  15.890  1.00 34.27 ? 201 MET C CG  1 
ATOM   1259 S SD  . MET C 1 47 ? 26.526 -0.653  14.705  1.00 46.06 ? 201 MET C SD  1 
ATOM   1260 C CE  . MET C 1 47 ? 28.101 -1.294  15.058  1.00 47.93 ? 201 MET C CE  1 
ATOM   1261 N N   . ARG C 1 48 ? 21.821 -1.705  16.226  1.00 28.98 ? 202 ARG C N   1 
ATOM   1262 C CA  . ARG C 1 48 ? 20.844 -0.742  16.762  1.00 30.05 ? 202 ARG C CA  1 
ATOM   1263 C C   . ARG C 1 48 ? 20.210 -1.264  18.059  1.00 31.06 ? 202 ARG C C   1 
ATOM   1264 O O   . ARG C 1 48 ? 20.107 -0.514  19.028  1.00 32.24 ? 202 ARG C O   1 
ATOM   1265 C CB  . ARG C 1 48 ? 19.748 -0.474  15.734  1.00 32.33 ? 202 ARG C CB  1 
ATOM   1266 C CG  . ARG C 1 48 ? 20.239 0.231   14.488  1.00 37.83 ? 202 ARG C CG  1 
ATOM   1267 C CD  . ARG C 1 48 ? 20.145 1.730   14.619  1.00 44.76 ? 202 ARG C CD  1 
ATOM   1268 N NE  . ARG C 1 48 ? 20.505 2.415   13.376  1.00 49.44 ? 202 ARG C NE  1 
ATOM   1269 C CZ  . ARG C 1 48 ? 21.383 3.414   13.300  1.00 53.65 ? 202 ARG C CZ  1 
ATOM   1270 N NH1 . ARG C 1 48 ? 22.019 3.835   14.389  1.00 54.01 ? 202 ARG C NH1 1 
ATOM   1271 N NH2 . ARG C 1 48 ? 21.663 3.971   12.128  1.00 54.12 ? 202 ARG C NH2 1 
ATOM   1272 N N   . ASN C 1 49 ? 19.851 -2.552  18.088  1.00 31.24 ? 203 ASN C N   1 
ATOM   1273 C CA  . ASN C 1 49 ? 19.293 -3.242  19.248  1.00 33.03 ? 203 ASN C CA  1 
ATOM   1274 C C   . ASN C 1 49 ? 20.248 -3.216  20.455  1.00 32.67 ? 203 ASN C C   1 
ATOM   1275 O O   . ASN C 1 49 ? 19.808 -2.995  21.579  1.00 32.62 ? 203 ASN C O   1 
ATOM   1276 C CB  . ASN C 1 49 ? 18.943 -4.677  18.885  1.00 36.29 ? 203 ASN C CB  1 
ATOM   1277 C CG  . ASN C 1 49 ? 18.289 -5.456  19.990  1.00 44.38 ? 203 ASN C CG  1 
ATOM   1278 O OD1 . ASN C 1 49 ? 18.938 -5.982  20.913  1.00 47.91 ? 203 ASN C OD1 1 
ATOM   1279 N ND2 . ASN C 1 49 ? 16.970 -5.560  19.911  1.00 45.58 ? 203 ASN C ND2 1 
ATOM   1280 N N   . ARG C 1 50 ? 21.538 -3.445  20.225  1.00 32.73 ? 204 ARG C N   1 
ATOM   1281 C CA  . ARG C 1 50 ? 22.539 -3.400  21.293  1.00 33.69 ? 204 ARG C CA  1 
ATOM   1282 C C   . ARG C 1 50 ? 22.617 -1.997  21.896  1.00 34.10 ? 204 ARG C C   1 
ATOM   1283 O O   . ARG C 1 50 ? 22.623 -1.871  23.114  1.00 33.95 ? 204 ARG C O   1 
ATOM   1284 C CB  . ARG C 1 50 ? 23.911 -3.854  20.788  1.00 34.52 ? 204 ARG C CB  1 
ATOM   1285 C CG  . ARG C 1 50 ? 23.918 -5.359  20.515  1.00 35.66 ? 204 ARG C CG  1 
ATOM   1286 C CD  . ARG C 1 50 ? 25.309 -5.952  20.301  1.00 36.92 ? 204 ARG C CD  1 
ATOM   1287 N NE  . ARG C 1 50 ? 26.068 -5.318  19.228  1.00 38.50 ? 204 ARG C NE  1 
ATOM   1288 C CZ  . ARG C 1 50 ? 26.017 -5.675  17.945  1.00 40.84 ? 204 ARG C CZ  1 
ATOM   1289 N NH1 . ARG C 1 50 ? 26.742 -5.032  17.045  1.00 40.53 ? 204 ARG C NH1 1 
ATOM   1290 N NH2 . ARG C 1 50 ? 25.180 -6.623  17.545  1.00 41.13 ? 204 ARG C NH2 1 
ATOM   1291 N N   . ASP C 1 51 ? 22.597 -0.956  21.052  1.00 34.47 ? 205 ASP C N   1 
ATOM   1292 C CA  . ASP C 1 51 ? 22.634 0.450   21.488  1.00 35.54 ? 205 ASP C CA  1 
ATOM   1293 C C   . ASP C 1 51 ? 21.389 0.825   22.297  1.00 36.75 ? 205 ASP C C   1 
ATOM   1294 O O   . ASP C 1 51 ? 21.498 1.550   23.284  1.00 37.24 ? 205 ASP C O   1 
ATOM   1295 C CB  . ASP C 1 51 ? 22.766 1.384   20.282  1.00 37.45 ? 205 ASP C CB  1 
ATOM   1296 C CG  . ASP C 1 51 ? 24.091 1.296   19.557  1.00 42.35 ? 205 ASP C CG  1 
ATOM   1297 O OD1 . ASP C 1 51 ? 25.047 0.765   20.141  1.00 42.62 ? 205 ASP C OD1 1 
ATOM   1298 O OD2 . ASP C 1 51 ? 24.166 1.757   18.393  1.00 45.68 ? 205 ASP C OD2 1 
ATOM   1299 N N   . LEU C 1 52 ? 20.209 0.339   21.878  1.00 36.90 ? 206 LEU C N   1 
ATOM   1300 C CA  . LEU C 1 52 ? 18.964 0.593   22.597  1.00 37.90 ? 206 LEU C CA  1 
ATOM   1301 C C   . LEU C 1 52 ? 18.988 -0.113  23.953  1.00 40.38 ? 206 LEU C C   1 
ATOM   1302 O O   . LEU C 1 52 ? 18.543 0.456   24.947  1.00 40.53 ? 206 LEU C O   1 
ATOM   1303 C CB  . LEU C 1 52 ? 17.742 0.128   21.791  1.00 37.92 ? 206 LEU C CB  1 
ATOM   1304 C CG  . LEU C 1 52 ? 17.434 0.925   20.526  1.00 40.00 ? 206 LEU C CG  1 
ATOM   1305 C CD1 . LEU C 1 52 ? 16.308 0.270   19.718  1.00 40.77 ? 206 LEU C CD1 1 
ATOM   1306 C CD2 . LEU C 1 52 ? 17.086 2.359   20.854  1.00 40.98 ? 206 LEU C CD2 1 
ATOM   1307 N N   . GLN C 1 53 ? 19.520 -1.338  24.010  1.00 42.41 ? 207 GLN C N   1 
ATOM   1308 C CA  . GLN C 1 53 ? 19.601 -2.072  25.277  1.00 45.29 ? 207 GLN C CA  1 
ATOM   1309 C C   . GLN C 1 53 ? 20.539 -1.353  26.266  1.00 47.28 ? 207 GLN C C   1 
ATOM   1310 O O   . GLN C 1 53 ? 20.240 -1.301  27.451  1.00 47.85 ? 207 GLN C O   1 
ATOM   1311 C CB  . GLN C 1 53 ? 19.992 -3.537  25.051  1.00 47.70 ? 207 GLN C CB  1 
ATOM   1312 C CG  . GLN C 1 53 ? 19.824 -4.390  26.287  1.00 52.72 ? 207 GLN C CG  1 
ATOM   1313 C CD  . GLN C 1 53 ? 18.439 -4.410  26.856  1.00 58.86 ? 207 GLN C CD  1 
ATOM   1314 O OE1 . GLN C 1 53 ? 17.482 -4.845  26.206  1.00 60.26 ? 207 GLN C OE1 1 
ATOM   1315 N NE2 . GLN C 1 53 ? 18.312 -3.945  28.098  1.00 61.09 ? 207 GLN C NE2 1 
ATOM   1316 N N   . LEU C 1 54 ? 21.609 -0.716  25.760  1.00 48.47 ? 208 LEU C N   1 
ATOM   1317 C CA  . LEU C 1 54 ? 22.552 0.089   26.541  1.00 50.63 ? 208 LEU C CA  1 
ATOM   1318 C C   . LEU C 1 54 ? 21.768 1.261   27.190  1.00 52.40 ? 208 LEU C C   1 
ATOM   1319 O O   . LEU C 1 54 ? 21.896 1.508   28.390  1.00 52.50 ? 208 LEU C O   1 
ATOM   1320 C CB  . LEU C 1 54 ? 23.652 0.658   25.599  1.00 51.16 ? 208 LEU C CB  1 
ATOM   1321 C CG  . LEU C 1 54 ? 25.030 -0.036  25.504  1.00 53.42 ? 208 LEU C CG  1 
ATOM   1322 C CD1 . LEU C 1 54 ? 24.916 -1.541  25.460  1.00 54.30 ? 208 LEU C CD1 1 
ATOM   1323 C CD2 . LEU C 1 54 ? 25.810 0.441   24.260  1.00 54.02 ? 208 LEU C CD2 1 
ATOM   1324 N N   . GLU C 1 55 ? 20.932 1.946   26.397  1.00 53.43 ? 209 GLU C N   1 
ATOM   1325 C CA  . GLU C 1 55 ? 20.107 3.077   26.839  1.00 55.06 ? 209 GLU C CA  1 
ATOM   1326 C C   . GLU C 1 55 ? 19.118 2.690   27.945  1.00 56.50 ? 209 GLU C C   1 
ATOM   1327 O O   . GLU C 1 55 ? 18.998 3.425   28.923  1.00 56.77 ? 209 GLU C O   1 
ATOM   1328 C CB  . GLU C 1 55 ? 19.331 3.676   25.657  1.00 57.17 ? 209 GLU C CB  1 
ATOM   1329 C CG  . GLU C 1 55 ? 20.168 4.479   24.684  1.00 62.23 ? 209 GLU C CG  1 
ATOM   1330 C CD  . GLU C 1 55 ? 19.332 5.159   23.613  1.00 69.43 ? 209 GLU C CD  1 
ATOM   1331 O OE1 . GLU C 1 55 ? 18.296 5.771   23.964  1.00 69.49 ? 209 GLU C OE1 1 
ATOM   1332 O OE2 . GLU C 1 55 ? 19.713 5.075   22.422  1.00 72.24 ? 209 GLU C OE2 1 
ATOM   1333 N N   . ILE C 1 56 ? 18.406 1.547   27.789  1.00 57.25 ? 210 ILE C N   1 
ATOM   1334 C CA  . ILE C 1 56 ? 17.431 1.060   28.775  1.00 58.84 ? 210 ILE C CA  1 
ATOM   1335 C C   . ILE C 1 56 ? 18.108 0.762   30.105  1.00 60.33 ? 210 ILE C C   1 
ATOM   1336 O O   . ILE C 1 56 ? 17.585 1.130   31.161  1.00 60.44 ? 210 ILE C O   1 
ATOM   1337 C CB  . ILE C 1 56 ? 16.695 -0.210  28.284  1.00 59.30 ? 210 ILE C CB  1 
ATOM   1338 C CG1 . ILE C 1 56 ? 15.952 0.039   26.996  1.00 60.25 ? 210 ILE C CG1 1 
ATOM   1339 C CG2 . ILE C 1 56 ? 15.758 -0.767  29.358  1.00 59.75 ? 210 ILE C CG2 1 
ATOM   1340 C CD1 . ILE C 1 56 ? 15.697 -1.188  26.272  1.00 61.46 ? 210 ILE C CD1 1 
ATOM   1341 N N   . ASP C 1 57 ? 19.270 0.099   30.050  1.00 60.92 ? 211 ASP C N   1 
ATOM   1342 C CA  . ASP C 1 57 ? 20.028 -0.274  31.237  1.00 62.27 ? 211 ASP C CA  1 
ATOM   1343 C C   . ASP C 1 57 ? 20.460 0.940   32.082  1.00 63.68 ? 211 ASP C C   1 
ATOM   1344 O O   . ASP C 1 57 ? 20.603 0.825   33.299  1.00 63.91 ? 211 ASP C O   1 
ATOM   1345 C CB  . ASP C 1 57 ? 21.215 -1.140  30.835  1.00 63.35 ? 211 ASP C CB  1 
ATOM   1346 C CG  . ASP C 1 57 ? 20.852 -2.545  30.357  1.00 66.58 ? 211 ASP C CG  1 
ATOM   1347 O OD1 . ASP C 1 57 ? 21.750 -3.249  29.852  1.00 66.41 ? 211 ASP C OD1 1 
ATOM   1348 O OD2 . ASP C 1 57 ? 19.669 -2.934  30.485  1.00 68.42 ? 211 ASP C OD2 1 
ATOM   1349 N N   . GLN C 1 58 ? 20.610 2.110   31.449  1.00 64.46 ? 212 GLN C N   1 
ATOM   1350 C CA  . GLN C 1 58 ? 20.929 3.350   32.157  1.00 65.81 ? 212 GLN C CA  1 
ATOM   1351 C C   . GLN C 1 58 ? 19.669 3.980   32.805  1.00 66.91 ? 212 GLN C C   1 
ATOM   1352 O O   . GLN C 1 58 ? 19.776 4.687   33.802  1.00 67.16 ? 212 GLN C O   1 
ATOM   1353 C CB  . GLN C 1 58 ? 21.589 4.351   31.199  1.00 67.36 ? 212 GLN C CB  1 
ATOM   1354 C CG  . GLN C 1 58 ? 22.952 3.882   30.683  1.00 70.45 ? 212 GLN C CG  1 
ATOM   1355 C CD  . GLN C 1 58 ? 23.460 4.637   29.465  1.00 74.61 ? 212 GLN C CD  1 
ATOM   1356 O OE1 . GLN C 1 58 ? 24.537 4.340   28.942  1.00 76.10 ? 212 GLN C OE1 1 
ATOM   1357 N NE2 . GLN C 1 58 ? 22.717 5.624   28.970  1.00 75.06 ? 212 GLN C NE2 1 
ATOM   1358 N N   . LEU C 1 59 ? 18.489 3.740   32.228  1.00 67.50 ? 213 LEU C N   1 
ATOM   1359 C CA  . LEU C 1 59 ? 17.223 4.262   32.743  1.00 68.57 ? 213 LEU C CA  1 
ATOM   1360 C C   . LEU C 1 59 ? 16.619 3.371   33.838  1.00 70.03 ? 213 LEU C C   1 
ATOM   1361 O O   . LEU C 1 59 ? 15.851 3.853   34.667  1.00 70.55 ? 213 LEU C O   1 
ATOM   1362 C CB  . LEU C 1 59 ? 16.225 4.474   31.599  1.00 68.56 ? 213 LEU C CB  1 
ATOM   1363 C CG  . LEU C 1 59 ? 16.695 5.418   30.503  1.00 69.92 ? 213 LEU C CG  1 
ATOM   1364 C CD1 . LEU C 1 59 ? 15.741 5.419   29.329  1.00 70.24 ? 213 LEU C CD1 1 
ATOM   1365 C CD2 . LEU C 1 59 ? 16.881 6.815   31.035  1.00 70.75 ? 213 LEU C CD2 1 
ATOM   1366 N N   . LYS C 1 60 ? 16.986 2.082   33.859  1.00 70.44 ? 214 LYS C N   1 
ATOM   1367 C CA  . LYS C 1 60 ? 16.543 1.157   34.892  1.00 71.24 ? 214 LYS C CA  1 
ATOM   1368 C C   . LYS C 1 60 ? 17.632 1.060   35.968  1.00 71.69 ? 214 LYS C C   1 
ATOM   1369 O O   . LYS C 1 60 ? 18.276 2.063   36.297  1.00 71.87 ? 214 LYS C O   1 
ATOM   1370 C CB  . LYS C 1 60 ? 16.254 -0.230  34.295  1.00 73.20 ? 214 LYS C CB  1 
ATOM   1371 C CG  . LYS C 1 60 ? 15.029 -0.263  33.394  1.00 77.47 ? 214 LYS C CG  1 
ATOM   1372 C CD  . LYS C 1 60 ? 14.672 -1.689  32.977  1.00 81.91 ? 214 LYS C CD  1 
ATOM   1373 C CE  . LYS C 1 60 ? 14.207 -2.532  34.140  1.00 85.48 ? 214 LYS C CE  1 
ATOM   1374 N NZ  . LYS C 1 60 ? 13.650 -3.835  33.688  1.00 87.63 ? 214 LYS C NZ  1 
ATOM   1375 N N   . ALA D 1 1  ? 25.680 -42.900 -39.629 1.00 39.54 ? 155 ALA D N   1 
ATOM   1376 C CA  . ALA D 1 1  ? 26.134 -41.852 -40.537 1.00 39.07 ? 155 ALA D CA  1 
ATOM   1377 C C   . ALA D 1 1  ? 25.861 -40.434 -39.928 1.00 36.99 ? 155 ALA D C   1 
ATOM   1378 O O   . ALA D 1 1  ? 25.368 -40.360 -38.802 1.00 37.46 ? 155 ALA D O   1 
ATOM   1379 C CB  . ALA D 1 1  ? 25.480 -42.045 -41.904 1.00 39.82 ? 155 ALA D CB  1 
ATOM   1380 N N   . LYS D 1 2  ? 26.256 -39.329 -40.613 1.00 34.26 ? 156 LYS D N   1 
ATOM   1381 C CA  . LYS D 1 2  ? 26.168 -37.965 -40.120 1.00 32.45 ? 156 LYS D CA  1 
ATOM   1382 C C   . LYS D 1 2  ? 24.836 -37.523 -39.535 1.00 30.01 ? 156 LYS D C   1 
ATOM   1383 O O   . LYS D 1 2  ? 24.875 -36.958 -38.449 1.00 30.07 ? 156 LYS D O   1 
ATOM   1384 C CB  . LYS D 1 2  ? 26.603 -36.947 -41.175 1.00 34.39 ? 156 LYS D CB  1 
ATOM   1385 C CG  . LYS D 1 2  ? 27.982 -36.434 -40.884 1.00 39.57 ? 156 LYS D CG  1 
ATOM   1386 C CD  . LYS D 1 2  ? 28.019 -34.928 -40.729 1.00 43.31 ? 156 LYS D CD  1 
ATOM   1387 C CE  . LYS D 1 2  ? 28.235 -34.289 -42.066 1.00 45.04 ? 156 LYS D CE  1 
ATOM   1388 N NZ  . LYS D 1 2  ? 29.186 -33.143 -41.990 1.00 45.29 ? 156 LYS D NZ  1 
ATOM   1389 N N   . HIS D 1 3  ? 23.691 -37.695 -40.233 1.00 28.21 ? 157 HIS D N   1 
ATOM   1390 C CA  . HIS D 1 3  ? 22.410 -37.247 -39.654 1.00 28.68 ? 157 HIS D CA  1 
ATOM   1391 C C   . HIS D 1 3  ? 22.125 -37.929 -38.291 1.00 29.54 ? 157 HIS D C   1 
ATOM   1392 O O   . HIS D 1 3  ? 21.794 -37.229 -37.343 1.00 29.16 ? 157 HIS D O   1 
ATOM   1393 C CB  . HIS D 1 3  ? 21.242 -37.417 -40.633 1.00 28.76 ? 157 HIS D CB  1 
ATOM   1394 C CG  . HIS D 1 3  ? 19.896 -37.322 -39.991 1.00 31.56 ? 157 HIS D CG  1 
ATOM   1395 N ND1 . HIS D 1 3  ? 19.364 -36.104 -39.628 1.00 33.31 ? 157 HIS D ND1 1 
ATOM   1396 C CD2 . HIS D 1 3  ? 19.035 -38.305 -39.630 1.00 32.70 ? 157 HIS D CD2 1 
ATOM   1397 C CE1 . HIS D 1 3  ? 18.184 -36.369 -39.090 1.00 34.04 ? 157 HIS D CE1 1 
ATOM   1398 N NE2 . HIS D 1 3  ? 17.952 -37.684 -39.044 1.00 33.58 ? 157 HIS D NE2 1 
ATOM   1399 N N   . GLN D 1 4  ? 22.264 -39.271 -38.209 1.00 29.68 ? 158 GLN D N   1 
ATOM   1400 C CA  . GLN D 1 4  ? 22.030 -40.043 -36.984 1.00 31.12 ? 158 GLN D CA  1 
ATOM   1401 C C   . GLN D 1 4  ? 22.964 -39.559 -35.866 1.00 31.68 ? 158 GLN D C   1 
ATOM   1402 O O   . GLN D 1 4  ? 22.556 -39.514 -34.704 1.00 30.76 ? 158 GLN D O   1 
ATOM   1403 C CB  . GLN D 1 4  ? 22.277 -41.548 -37.242 1.00 33.94 ? 158 GLN D CB  1 
ATOM   1404 C CG  . GLN D 1 4  ? 21.101 -42.277 -37.848 1.00 40.45 ? 158 GLN D CG  1 
ATOM   1405 C CD  . GLN D 1 4  ? 21.499 -43.567 -38.546 1.00 49.81 ? 158 GLN D CD  1 
ATOM   1406 O OE1 . GLN D 1 4  ? 22.582 -44.143 -38.320 1.00 53.32 ? 158 GLN D OE1 1 
ATOM   1407 N NE2 . GLN D 1 4  ? 20.623 -44.058 -39.419 1.00 50.51 ? 158 GLN D NE2 1 
ATOM   1408 N N   . GLU D 1 5  ? 24.233 -39.241 -36.219 1.00 32.05 ? 159 GLU D N   1 
ATOM   1409 C CA  . GLU D 1 5  ? 25.240 -38.772 -35.272 1.00 33.62 ? 159 GLU D CA  1 
ATOM   1410 C C   . GLU D 1 5  ? 24.852 -37.413 -34.688 1.00 34.88 ? 159 GLU D C   1 
ATOM   1411 O O   . GLU D 1 5  ? 24.958 -37.206 -33.479 1.00 34.96 ? 159 GLU D O   1 
ATOM   1412 C CB  . GLU D 1 5  ? 26.635 -38.707 -35.932 1.00 36.13 ? 159 GLU D CB  1 
ATOM   1413 C CG  . GLU D 1 5  ? 27.277 -40.071 -36.131 1.00 41.31 ? 159 GLU D CG  1 
ATOM   1414 C CD  . GLU D 1 5  ? 28.516 -40.112 -37.019 1.00 47.59 ? 159 GLU D CD  1 
ATOM   1415 O OE1 . GLU D 1 5  ? 28.956 -39.039 -37.492 1.00 50.40 ? 159 GLU D OE1 1 
ATOM   1416 O OE2 . GLU D 1 5  ? 29.037 -41.226 -37.253 1.00 48.23 ? 159 GLU D OE2 1 
ATOM   1417 N N   . ARG D 1 6  ? 24.361 -36.505 -35.538 1.00 35.72 ? 160 ARG D N   1 
ATOM   1418 C CA  . ARG D 1 6  ? 23.941 -35.171 -35.115 1.00 37.79 ? 160 ARG D CA  1 
ATOM   1419 C C   . ARG D 1 6  ? 22.714 -35.248 -34.198 1.00 38.83 ? 160 ARG D C   1 
ATOM   1420 O O   . ARG D 1 6  ? 22.698 -34.579 -33.160 1.00 39.91 ? 160 ARG D O   1 
ATOM   1421 C CB  . ARG D 1 6  ? 23.721 -34.262 -36.339 1.00 39.55 ? 160 ARG D CB  1 
ATOM   1422 C CG  . ARG D 1 6  ? 23.874 -32.757 -36.054 1.00 43.74 ? 160 ARG D CG  1 
ATOM   1423 C CD  . ARG D 1 6  ? 23.321 -31.889 -37.201 1.00 47.23 ? 160 ARG D CD  1 
ATOM   1424 N NE  . ARG D 1 6  ? 21.989 -32.315 -37.635 1.00 50.63 ? 160 ARG D NE  1 
ATOM   1425 C CZ  . ARG D 1 6  ? 20.853 -31.978 -37.029 1.00 54.00 ? 160 ARG D CZ  1 
ATOM   1426 N NH1 . ARG D 1 6  ? 20.868 -31.175 -35.972 1.00 53.74 ? 160 ARG D NH1 1 
ATOM   1427 N NH2 . ARG D 1 6  ? 19.694 -32.437 -37.480 1.00 54.76 ? 160 ARG D NH2 1 
ATOM   1428 N N   . VAL D 1 7  ? 21.756 -36.142 -34.507 1.00 38.63 ? 161 VAL D N   1 
ATOM   1429 C CA  . VAL D 1 7  ? 20.541 -36.392 -33.705 1.00 39.59 ? 161 VAL D CA  1 
ATOM   1430 C C   . VAL D 1 7  ? 20.907 -36.991 -32.321 1.00 39.84 ? 161 VAL D C   1 
ATOM   1431 O O   . VAL D 1 7  ? 20.365 -36.572 -31.285 1.00 39.83 ? 161 VAL D O   1 
ATOM   1432 C CB  . VAL D 1 7  ? 19.543 -37.310 -34.477 1.00 40.77 ? 161 VAL D CB  1 
ATOM   1433 C CG1 . VAL D 1 7  ? 18.418 -37.828 -33.583 1.00 41.84 ? 161 VAL D CG1 1 
ATOM   1434 C CG2 . VAL D 1 7  ? 18.977 -36.605 -35.702 1.00 41.34 ? 161 VAL D CG2 1 
ATOM   1435 N N   . GLN D 1 8  ? 21.842 -37.940 -32.308 1.00 39.04 ? 162 GLN D N   1 
ATOM   1436 C CA  . GLN D 1 8  ? 22.288 -38.564 -31.072 1.00 39.73 ? 162 GLN D CA  1 
ATOM   1437 C C   . GLN D 1 8  ? 23.036 -37.573 -30.189 1.00 40.38 ? 162 GLN D C   1 
ATOM   1438 O O   . GLN D 1 8  ? 22.793 -37.532 -28.986 1.00 40.34 ? 162 GLN D O   1 
ATOM   1439 C CB  . GLN D 1 8  ? 23.147 -39.807 -31.368 1.00 40.74 ? 162 GLN D CB  1 
ATOM   1440 C CG  . GLN D 1 8  ? 23.590 -40.585 -30.129 1.00 43.88 ? 162 GLN D CG  1 
ATOM   1441 C CD  . GLN D 1 8  ? 22.437 -41.063 -29.275 1.00 49.82 ? 162 GLN D CD  1 
ATOM   1442 O OE1 . GLN D 1 8  ? 22.502 -41.040 -28.042 1.00 52.97 ? 162 GLN D OE1 1 
ATOM   1443 N NE2 . GLN D 1 8  ? 21.365 -41.525 -29.901 1.00 50.02 ? 162 GLN D NE2 1 
ATOM   1444 N N   . ARG D 1 9  ? 23.872 -36.720 -30.798 1.00 41.24 ? 163 ARG D N   1 
ATOM   1445 C CA  . ARG D 1 9  ? 24.655 -35.702 -30.090 1.00 42.80 ? 163 ARG D CA  1 
ATOM   1446 C C   . ARG D 1 9  ? 23.757 -34.664 -29.429 1.00 43.78 ? 163 ARG D C   1 
ATOM   1447 O O   . ARG D 1 9  ? 24.014 -34.254 -28.297 1.00 43.53 ? 163 ARG D O   1 
ATOM   1448 C CB  . ARG D 1 9  ? 25.648 -35.023 -31.036 1.00 45.34 ? 163 ARG D CB  1 
ATOM   1449 C CG  . ARG D 1 9  ? 26.866 -34.410 -30.332 1.00 50.56 ? 163 ARG D CG  1 
ATOM   1450 C CD  . ARG D 1 9  ? 28.044 -34.156 -31.280 1.00 55.69 ? 163 ARG D CD  1 
ATOM   1451 N NE  . ARG D 1 9  ? 28.293 -35.297 -32.169 1.00 60.33 ? 163 ARG D NE  1 
ATOM   1452 C CZ  . ARG D 1 9  ? 29.478 -35.612 -32.684 1.00 63.55 ? 163 ARG D CZ  1 
ATOM   1453 N NH1 . ARG D 1 9  ? 30.544 -34.870 -32.414 1.00 63.94 ? 163 ARG D NH1 1 
ATOM   1454 N NH2 . ARG D 1 9  ? 29.603 -36.670 -33.478 1.00 63.06 ? 163 ARG D NH2 1 
ATOM   1455 N N   . LEU D 1 10 ? 22.690 -34.275 -30.113 1.00 44.49 ? 164 LEU D N   1 
ATOM   1456 C CA  . LEU D 1 10 ? 21.729 -33.324 -29.565 1.00 46.06 ? 164 LEU D CA  1 
ATOM   1457 C C   . LEU D 1 10 ? 20.983 -33.943 -28.388 1.00 45.95 ? 164 LEU D C   1 
ATOM   1458 O O   . LEU D 1 10 ? 20.760 -33.262 -27.400 1.00 46.31 ? 164 LEU D O   1 
ATOM   1459 C CB  . LEU D 1 10 ? 20.751 -32.880 -30.656 1.00 47.41 ? 164 LEU D CB  1 
ATOM   1460 C CG  . LEU D 1 10 ? 20.739 -31.394 -31.006 1.00 50.63 ? 164 LEU D CG  1 
ATOM   1461 C CD1 . LEU D 1 10 ? 22.152 -30.855 -31.308 1.00 51.52 ? 164 LEU D CD1 1 
ATOM   1462 C CD2 . LEU D 1 10 ? 19.829 -31.135 -32.205 1.00 51.71 ? 164 LEU D CD2 1 
ATOM   1463 N N   . LYS D 1 11 ? 20.639 -35.233 -28.482 1.00 45.57 ? 165 LYS D N   1 
ATOM   1464 C CA  . LYS D 1 11 ? 19.972 -36.002 -27.432 1.00 45.80 ? 165 LYS D CA  1 
ATOM   1465 C C   . LYS D 1 11 ? 20.850 -36.103 -26.162 1.00 45.91 ? 165 LYS D C   1 
ATOM   1466 O O   . LYS D 1 11 ? 20.361 -35.873 -25.057 1.00 45.95 ? 165 LYS D O   1 
ATOM   1467 C CB  . LYS D 1 11 ? 19.621 -37.405 -27.956 1.00 47.43 ? 165 LYS D CB  1 
ATOM   1468 C CG  . LYS D 1 11 ? 19.008 -38.323 -26.914 1.00 52.79 ? 165 LYS D CG  1 
ATOM   1469 C CD  . LYS D 1 11 ? 18.322 -39.515 -27.547 1.00 58.38 ? 165 LYS D CD  1 
ATOM   1470 C CE  . LYS D 1 11 ? 17.558 -40.318 -26.517 1.00 62.71 ? 165 LYS D CE  1 
ATOM   1471 N NZ  . LYS D 1 11 ? 18.461 -41.129 -25.658 1.00 65.09 ? 165 LYS D NZ  1 
ATOM   1472 N N   . GLU D 1 12 ? 22.148 -36.395 -26.328 1.00 45.74 ? 166 GLU D N   1 
ATOM   1473 C CA  . GLU D 1 12 ? 23.076 -36.510 -25.198 1.00 46.05 ? 166 GLU D CA  1 
ATOM   1474 C C   . GLU D 1 12 ? 23.249 -35.173 -24.479 1.00 47.12 ? 166 GLU D C   1 
ATOM   1475 O O   . GLU D 1 12 ? 23.075 -35.105 -23.256 1.00 47.24 ? 166 GLU D O   1 
ATOM   1476 C CB  . GLU D 1 12 ? 24.430 -37.084 -25.653 1.00 47.09 ? 166 GLU D CB  1 
ATOM   1477 C CG  . GLU D 1 12 ? 24.333 -38.529 -26.102 1.00 50.63 ? 166 GLU D CG  1 
ATOM   1478 C CD  . GLU D 1 12 ? 25.497 -39.039 -26.933 1.00 56.68 ? 166 GLU D CD  1 
ATOM   1479 O OE1 . GLU D 1 12 ? 26.389 -38.230 -27.284 1.00 57.01 ? 166 GLU D OE1 1 
ATOM   1480 O OE2 . GLU D 1 12 ? 25.507 -40.252 -27.245 1.00 58.26 ? 166 GLU D OE2 1 
ATOM   1481 N N   . GLU D 1 13 ? 23.509 -34.094 -25.233 1.00 47.30 ? 167 GLU D N   1 
ATOM   1482 C CA  . GLU D 1 13 ? 23.662 -32.769 -24.631 1.00 47.90 ? 167 GLU D CA  1 
ATOM   1483 C C   . GLU D 1 13 ? 22.350 -32.258 -23.992 1.00 47.71 ? 167 GLU D C   1 
ATOM   1484 O O   . GLU D 1 13 ? 22.397 -31.446 -23.068 1.00 47.74 ? 167 GLU D O   1 
ATOM   1485 C CB  . GLU D 1 13 ? 24.267 -31.758 -25.623 1.00 50.36 ? 167 GLU D CB  1 
ATOM   1486 C CG  . GLU D 1 13 ? 23.326 -31.411 -26.760 1.00 55.55 ? 167 GLU D CG  1 
ATOM   1487 C CD  . GLU D 1 13 ? 23.870 -30.445 -27.794 1.00 62.66 ? 167 GLU D CD  1 
ATOM   1488 O OE1 . GLU D 1 13 ? 25.044 -30.604 -28.208 1.00 63.00 ? 167 GLU D OE1 1 
ATOM   1489 O OE2 . GLU D 1 13 ? 23.111 -29.533 -28.198 1.00 65.40 ? 167 GLU D OE2 1 
ATOM   1490 N N   . CYS D 1 14 ? 21.197 -32.762 -24.446 1.00 47.58 ? 168 CYS D N   1 
ATOM   1491 C CA  . CYS D 1 14 ? 19.894 -32.426 -23.860 1.00 48.23 ? 168 CYS D CA  1 
ATOM   1492 C C   . CYS D 1 14 ? 19.718 -33.159 -22.533 1.00 47.64 ? 168 CYS D C   1 
ATOM   1493 O O   . CYS D 1 14 ? 19.184 -32.584 -21.578 1.00 47.52 ? 168 CYS D O   1 
ATOM   1494 C CB  . CYS D 1 14 ? 18.756 -32.765 -24.814 1.00 50.07 ? 168 CYS D CB  1 
ATOM   1495 S SG  . CYS D 1 14 ? 17.102 -32.461 -24.130 1.00 56.79 ? 168 CYS D SG  1 
ATOM   1496 N N   . GLU D 1 15 ? 20.126 -34.438 -22.481 1.00 46.80 ? 169 GLU D N   1 
ATOM   1497 C CA  . GLU D 1 15 ? 20.057 -35.243 -21.257 1.00 46.38 ? 169 GLU D CA  1 
ATOM   1498 C C   . GLU D 1 15 ? 20.947 -34.613 -20.184 1.00 45.15 ? 169 GLU D C   1 
ATOM   1499 O O   . GLU D 1 15 ? 20.536 -34.522 -19.022 1.00 45.28 ? 169 GLU D O   1 
ATOM   1500 C CB  . GLU D 1 15 ? 20.503 -36.669 -21.533 1.00 46.64 ? 169 GLU D CB  1 
ATOM   1501 N N   . ALA D 1 16 ? 22.141 -34.135 -20.588 1.00 43.64 ? 170 ALA D N   1 
ATOM   1502 C CA  . ALA D 1 16 ? 23.084 -33.453 -19.709 1.00 43.18 ? 170 ALA D CA  1 
ATOM   1503 C C   . ALA D 1 16 ? 22.498 -32.108 -19.239 1.00 42.39 ? 170 ALA D C   1 
ATOM   1504 O O   . ALA D 1 16 ? 22.546 -31.803 -18.048 1.00 42.00 ? 170 ALA D O   1 
ATOM   1505 C CB  . ALA D 1 16 ? 24.406 -33.240 -20.429 1.00 43.33 ? 170 ALA D CB  1 
ATOM   1506 N N   . GLY D 1 17 ? 21.883 -31.361 -20.157 1.00 41.78 ? 171 GLY D N   1 
ATOM   1507 C CA  . GLY D 1 17 ? 21.255 -30.084 -19.834 1.00 41.81 ? 171 GLY D CA  1 
ATOM   1508 C C   . GLY D 1 17 ? 20.091 -30.219 -18.870 1.00 41.67 ? 171 GLY D C   1 
ATOM   1509 O O   . GLY D 1 17 ? 19.918 -29.366 -17.999 1.00 42.36 ? 171 GLY D O   1 
ATOM   1510 N N   . SER D 1 18 ? 19.313 -31.306 -18.981 1.00 40.86 ? 172 SER D N   1 
ATOM   1511 C CA  . SER D 1 18 ? 18.169 -31.545 -18.109 1.00 41.05 ? 172 SER D CA  1 
ATOM   1512 C C   . SER D 1 18 ? 18.600 -32.009 -16.693 1.00 40.57 ? 172 SER D C   1 
ATOM   1513 O O   . SER D 1 18 ? 17.909 -31.711 -15.711 1.00 40.23 ? 172 SER D O   1 
ATOM   1514 C CB  . SER D 1 18 ? 17.151 -32.480 -18.764 1.00 43.28 ? 172 SER D CB  1 
ATOM   1515 O OG  . SER D 1 18 ? 17.223 -33.828 -18.334 1.00 47.89 ? 172 SER D OG  1 
ATOM   1516 N N   . ARG D 1 19 ? 19.755 -32.671 -16.580 1.00 39.80 ? 173 ARG D N   1 
ATOM   1517 C CA  . ARG D 1 19 ? 20.291 -33.049 -15.271 1.00 39.39 ? 173 ARG D CA  1 
ATOM   1518 C C   . ARG D 1 19 ? 20.800 -31.791 -14.541 1.00 37.48 ? 173 ARG D C   1 
ATOM   1519 O O   . ARG D 1 19 ? 20.556 -31.634 -13.341 1.00 37.14 ? 173 ARG D O   1 
ATOM   1520 C CB  . ARG D 1 19 ? 21.398 -34.105 -15.406 1.00 41.54 ? 173 ARG D CB  1 
ATOM   1521 C CG  . ARG D 1 19 ? 20.820 -35.475 -15.718 1.00 46.65 ? 173 ARG D CG  1 
ATOM   1522 C CD  . ARG D 1 19 ? 21.856 -36.587 -15.636 1.00 51.97 ? 173 ARG D CD  1 
ATOM   1523 N NE  . ARG D 1 19 ? 22.422 -36.896 -16.948 1.00 56.82 ? 173 ARG D NE  1 
ATOM   1524 C CZ  . ARG D 1 19 ? 23.580 -36.420 -17.396 1.00 60.86 ? 173 ARG D CZ  1 
ATOM   1525 N NH1 . ARG D 1 19 ? 24.331 -35.639 -16.623 1.00 61.86 ? 173 ARG D NH1 1 
ATOM   1526 N NH2 . ARG D 1 19 ? 24.011 -36.741 -18.610 1.00 60.71 ? 173 ARG D NH2 1 
ATOM   1527 N N   . GLU D 1 20 ? 21.439 -30.869 -15.285 1.00 35.81 ? 174 GLU D N   1 
ATOM   1528 C CA  . GLU D 1 20 ? 21.902 -29.609 -14.727 1.00 35.88 ? 174 GLU D CA  1 
ATOM   1529 C C   . GLU D 1 20 ? 20.715 -28.731 -14.292 1.00 34.61 ? 174 GLU D C   1 
ATOM   1530 O O   . GLU D 1 20 ? 20.790 -28.063 -13.264 1.00 34.28 ? 174 GLU D O   1 
ATOM   1531 C CB  . GLU D 1 20 ? 22.805 -28.859 -15.724 1.00 40.02 ? 174 GLU D CB  1 
ATOM   1532 C CG  . GLU D 1 20 ? 23.436 -27.621 -15.111 1.00 48.57 ? 174 GLU D CG  1 
ATOM   1533 C CD  . GLU D 1 20 ? 24.497 -26.908 -15.924 1.00 59.56 ? 174 GLU D CD  1 
ATOM   1534 O OE1 . GLU D 1 20 ? 24.573 -27.138 -17.154 1.00 62.02 ? 174 GLU D OE1 1 
ATOM   1535 O OE2 . GLU D 1 20 ? 25.262 -26.118 -15.322 1.00 62.37 ? 174 GLU D OE2 1 
ATOM   1536 N N   . LEU D 1 21 ? 19.610 -28.762 -15.052 1.00 33.58 ? 175 LEU D N   1 
ATOM   1537 C CA  . LEU D 1 21 ? 18.426 -27.973 -14.713 1.00 33.38 ? 175 LEU D CA  1 
ATOM   1538 C C   . LEU D 1 21 ? 17.809 -28.496 -13.412 1.00 33.24 ? 175 LEU D C   1 
ATOM   1539 O O   . LEU D 1 21 ? 17.453 -27.693 -12.549 1.00 33.14 ? 175 LEU D O   1 
ATOM   1540 C CB  . LEU D 1 21 ? 17.407 -28.014 -15.855 1.00 33.23 ? 175 LEU D CB  1 
ATOM   1541 C CG  . LEU D 1 21 ? 16.071 -27.310 -15.592 1.00 34.29 ? 175 LEU D CG  1 
ATOM   1542 C CD1 . LEU D 1 21 ? 16.268 -25.821 -15.290 1.00 34.53 ? 175 LEU D CD1 1 
ATOM   1543 C CD2 . LEU D 1 21 ? 15.126 -27.502 -16.759 1.00 34.93 ? 175 LEU D CD2 1 
ATOM   1544 N N   . LYS D 1 22 ? 17.751 -29.818 -13.243 1.00 32.99 ? 176 LYS D N   1 
ATOM   1545 C CA  . LYS D 1 22 ? 17.235 -30.462 -12.021 1.00 33.68 ? 176 LYS D CA  1 
ATOM   1546 C C   . LYS D 1 22 ? 18.048 -30.018 -10.796 1.00 33.64 ? 176 LYS D C   1 
ATOM   1547 O O   . LYS D 1 22 ? 17.473 -29.656 -9.767  1.00 33.87 ? 176 LYS D O   1 
ATOM   1548 C CB  . LYS D 1 22 ? 17.280 -31.995 -12.168 1.00 35.70 ? 176 LYS D CB  1 
ATOM   1549 C CG  . LYS D 1 22 ? 16.872 -32.742 -10.904 1.00 39.90 ? 176 LYS D CG  1 
ATOM   1550 C CD  . LYS D 1 22 ? 16.867 -34.263 -11.114 1.00 44.33 ? 176 LYS D CD  1 
ATOM   1551 C CE  . LYS D 1 22 ? 16.629 -35.014 -9.823  1.00 47.62 ? 176 LYS D CE  1 
ATOM   1552 N NZ  . LYS D 1 22 ? 15.324 -34.670 -9.209  1.00 49.16 ? 176 LYS D NZ  1 
ATOM   1553 N N   . ARG D 1 23 ? 19.376 -29.980 -10.940 1.00 33.60 ? 177 ARG D N   1 
ATOM   1554 C CA  . ARG D 1 23 ? 20.299 -29.548 -9.898  1.00 35.08 ? 177 ARG D CA  1 
ATOM   1555 C C   . ARG D 1 23 ? 20.091 -28.063 -9.543  1.00 34.37 ? 177 ARG D C   1 
ATOM   1556 O O   . ARG D 1 23 ? 20.047 -27.677 -8.368  1.00 33.83 ? 177 ARG D O   1 
ATOM   1557 C CB  . ARG D 1 23 ? 21.719 -29.751 -10.421 1.00 38.20 ? 177 ARG D CB  1 
ATOM   1558 C CG  . ARG D 1 23 ? 22.801 -29.904 -9.368  1.00 43.98 ? 177 ARG D CG  1 
ATOM   1559 C CD  . ARG D 1 23 ? 24.092 -30.297 -10.065 1.00 48.43 ? 177 ARG D CD  1 
ATOM   1560 N NE  . ARG D 1 23 ? 23.919 -31.491 -10.896 1.00 53.31 ? 177 ARG D NE  1 
ATOM   1561 C CZ  . ARG D 1 23 ? 24.279 -31.583 -12.172 1.00 56.90 ? 177 ARG D CZ  1 
ATOM   1562 N NH1 . ARG D 1 23 ? 24.877 -30.564 -12.775 1.00 56.66 ? 177 ARG D NH1 1 
ATOM   1563 N NH2 . ARG D 1 23 ? 24.062 -32.704 -12.850 1.00 58.30 ? 177 ARG D NH2 1 
ATOM   1564 N N   . CYS D 1 24 ? 19.959 -27.237 -10.576 1.00 33.50 ? 178 CYS D N   1 
ATOM   1565 C CA  . CYS D 1 24 ? 19.763 -25.814 -10.424 1.00 33.73 ? 178 CYS D CA  1 
ATOM   1566 C C   . CYS D 1 24 ? 18.447 -25.485 -9.725  1.00 32.46 ? 178 CYS D C   1 
ATOM   1567 O O   . CYS D 1 24 ? 18.434 -24.621 -8.854  1.00 32.79 ? 178 CYS D O   1 
ATOM   1568 C CB  . CYS D 1 24 ? 19.878 -25.117 -11.772 1.00 34.99 ? 178 CYS D CB  1 
ATOM   1569 S SG  . CYS D 1 24 ? 20.126 -23.332 -11.642 1.00 39.35 ? 178 CYS D SG  1 
ATOM   1570 N N   . LYS D 1 25 ? 17.370 -26.191 -10.058 1.00 31.88 ? 179 LYS D N   1 
ATOM   1571 C CA  . LYS D 1 25 ? 16.059 -25.981 -9.435  1.00 31.82 ? 179 LYS D CA  1 
ATOM   1572 C C   . LYS D 1 25 ? 16.079 -26.377 -7.965  1.00 31.89 ? 179 LYS D C   1 
ATOM   1573 O O   . LYS D 1 25 ? 15.471 -25.680 -7.174  1.00 31.63 ? 179 LYS D O   1 
ATOM   1574 C CB  . LYS D 1 25 ? 14.961 -26.753 -10.163 1.00 33.37 ? 179 LYS D CB  1 
ATOM   1575 C CG  . LYS D 1 25 ? 14.563 -26.128 -11.481 1.00 39.09 ? 179 LYS D CG  1 
ATOM   1576 C CD  . LYS D 1 25 ? 13.463 -26.984 -12.091 1.00 46.73 ? 179 LYS D CD  1 
ATOM   1577 C CE  . LYS D 1 25 ? 12.883 -26.393 -13.342 1.00 53.04 ? 179 LYS D CE  1 
ATOM   1578 N NZ  . LYS D 1 25 ? 11.929 -27.325 -14.026 1.00 56.02 ? 179 LYS D NZ  1 
ATOM   1579 N N   . GLU D 1 26 ? 16.791 -27.442 -7.591  1.00 32.00 ? 180 GLU D N   1 
ATOM   1580 C CA  . GLU D 1 26 ? 16.950 -27.852 -6.191  1.00 32.49 ? 180 GLU D CA  1 
ATOM   1581 C C   . GLU D 1 26 ? 17.715 -26.772 -5.414  1.00 31.38 ? 180 GLU D C   1 
ATOM   1582 O O   . GLU D 1 26 ? 17.339 -26.436 -4.289  1.00 31.74 ? 180 GLU D O   1 
ATOM   1583 C CB  . GLU D 1 26 ? 17.709 -29.190 -6.096  1.00 35.58 ? 180 GLU D CB  1 
ATOM   1584 C CG  . GLU D 1 26 ? 16.847 -30.374 -6.486  1.00 43.65 ? 180 GLU D CG  1 
ATOM   1585 C CD  . GLU D 1 26 ? 17.572 -31.676 -6.762  1.00 52.70 ? 180 GLU D CD  1 
ATOM   1586 O OE1 . GLU D 1 26 ? 18.824 -31.673 -6.745  1.00 55.16 ? 180 GLU D OE1 1 
ATOM   1587 O OE2 . GLU D 1 26 ? 16.887 -32.699 -7.002  1.00 54.91 ? 180 GLU D OE2 1 
ATOM   1588 N N   . GLU D 1 27 ? 18.768 -26.200 -6.019  1.00 29.68 ? 181 GLU D N   1 
ATOM   1589 C CA  . GLU D 1 27 ? 19.545 -25.144 -5.384  1.00 29.29 ? 181 GLU D CA  1 
ATOM   1590 C C   . GLU D 1 27 ? 18.712 -23.861 -5.211  1.00 28.86 ? 181 GLU D C   1 
ATOM   1591 O O   . GLU D 1 27 ? 18.812 -23.189 -4.179  1.00 28.96 ? 181 GLU D O   1 
ATOM   1592 C CB  . GLU D 1 27 ? 20.812 -24.843 -6.193  1.00 32.06 ? 181 GLU D CB  1 
ATOM   1593 C CG  . GLU D 1 27 ? 21.856 -25.953 -6.071  1.00 37.25 ? 181 GLU D CG  1 
ATOM   1594 C CD  . GLU D 1 27 ? 23.000 -25.954 -7.062  1.00 45.58 ? 181 GLU D CD  1 
ATOM   1595 O OE1 . GLU D 1 27 ? 23.594 -27.040 -7.248  1.00 47.99 ? 181 GLU D OE1 1 
ATOM   1596 O OE2 . GLU D 1 27 ? 23.290 -24.895 -7.666  1.00 47.73 ? 181 GLU D OE2 1 
ATOM   1597 N N   . ASN D 1 28 ? 17.892 -23.547 -6.209  1.00 28.40 ? 182 ASN D N   1 
ATOM   1598 C CA  . ASN D 1 28 ? 17.015 -22.377 -6.217  1.00 29.69 ? 182 ASN D CA  1 
ATOM   1599 C C   . ASN D 1 28 ? 15.979 -22.495 -5.113  1.00 29.52 ? 182 ASN D C   1 
ATOM   1600 O O   . ASN D 1 28 ? 15.747 -21.511 -4.418  1.00 29.53 ? 182 ASN D O   1 
ATOM   1601 C CB  . ASN D 1 28 ? 16.374 -22.254 -7.616  1.00 32.13 ? 182 ASN D CB  1 
ATOM   1602 C CG  . ASN D 1 28 ? 15.261 -21.282 -7.879  1.00 36.29 ? 182 ASN D CG  1 
ATOM   1603 O OD1 . ASN D 1 28 ? 14.101 -21.687 -8.066  1.00 38.35 ? 182 ASN D OD1 1 
ATOM   1604 N ND2 . ASN D 1 28 ? 15.608 -20.017 -8.061  1.00 35.56 ? 182 ASN D ND2 1 
ATOM   1605 N N   . TYR D 1 29 ? 15.396 -23.686 -4.915  1.00 29.34 ? 183 TYR D N   1 
ATOM   1606 C CA  . TYR D 1 29 ? 14.422 -23.931 -3.838  1.00 28.84 ? 183 TYR D CA  1 
ATOM   1607 C C   . TYR D 1 29 ? 15.070 -23.691 -2.463  1.00 27.95 ? 183 TYR D C   1 
ATOM   1608 O O   . TYR D 1 29 ? 14.472 -23.002 -1.631  1.00 27.16 ? 183 TYR D O   1 
ATOM   1609 C CB  . TYR D 1 29 ? 13.886 -25.369 -3.923  1.00 28.29 ? 183 TYR D CB  1 
ATOM   1610 C CG  . TYR D 1 29 ? 12.762 -25.676 -2.963  1.00 28.44 ? 183 TYR D CG  1 
ATOM   1611 C CD1 . TYR D 1 29 ? 11.455 -25.411 -3.303  1.00 28.91 ? 183 TYR D CD1 1 
ATOM   1612 C CD2 . TYR D 1 29 ? 13.013 -26.256 -1.724  1.00 28.95 ? 183 TYR D CD2 1 
ATOM   1613 C CE1 . TYR D 1 29 ? 10.417 -25.670 -2.425  1.00 29.95 ? 183 TYR D CE1 1 
ATOM   1614 C CE2 . TYR D 1 29 ? 11.978 -26.567 -0.852  1.00 29.65 ? 183 TYR D CE2 1 
ATOM   1615 C CZ  . TYR D 1 29 ? 10.678 -26.265 -1.208  1.00 30.84 ? 183 TYR D CZ  1 
ATOM   1616 O OH  . TYR D 1 29 ? 9.622  -26.582 -0.397  1.00 32.22 ? 183 TYR D OH  1 
ATOM   1617 N N   . ASP D 1 30 ? 16.267 -24.240 -2.223  1.00 27.63 ? 184 ASP D N   1 
ATOM   1618 C CA  . ASP D 1 30 ? 16.980 -24.054 -0.962  1.00 29.38 ? 184 ASP D CA  1 
ATOM   1619 C C   . ASP D 1 30 ? 17.257 -22.570 -0.693  1.00 28.49 ? 184 ASP D C   1 
ATOM   1620 O O   . ASP D 1 30 ? 17.071 -22.127 0.440   1.00 28.52 ? 184 ASP D O   1 
ATOM   1621 C CB  . ASP D 1 30 ? 18.286 -24.886 -0.919  1.00 33.35 ? 184 ASP D CB  1 
ATOM   1622 C CG  . ASP D 1 30 ? 19.214 -24.648 0.278   1.00 45.42 ? 184 ASP D CG  1 
ATOM   1623 O OD1 . ASP D 1 30 ? 18.821 -24.995 1.416   1.00 49.12 ? 184 ASP D OD1 1 
ATOM   1624 O OD2 . ASP D 1 30 ? 20.354 -24.150 0.069   1.00 48.57 ? 184 ASP D OD2 1 
ATOM   1625 N N   . LEU D 1 31 ? 17.721 -21.823 -1.719  1.00 27.37 ? 185 LEU D N   1 
ATOM   1626 C CA  . LEU D 1 31 ? 18.017 -20.382 -1.597  1.00 27.21 ? 185 LEU D CA  1 
ATOM   1627 C C   . LEU D 1 31 ? 16.740 -19.584 -1.285  1.00 25.14 ? 185 LEU D C   1 
ATOM   1628 O O   . LEU D 1 31 ? 16.788 -18.685 -0.460  1.00 24.71 ? 185 LEU D O   1 
ATOM   1629 C CB  . LEU D 1 31 ? 18.657 -19.830 -2.881  1.00 28.76 ? 185 LEU D CB  1 
ATOM   1630 C CG  . LEU D 1 31 ? 20.121 -20.217 -3.085  1.00 31.95 ? 185 LEU D CG  1 
ATOM   1631 C CD1 . LEU D 1 31 ? 20.593 -19.840 -4.494  1.00 33.68 ? 185 LEU D CD1 1 
ATOM   1632 C CD2 . LEU D 1 31 ? 21.005 -19.576 -2.009  1.00 32.66 ? 185 LEU D CD2 1 
ATOM   1633 N N   . ALA D 1 32 ? 15.622 -19.925 -1.925  1.00 24.57 ? 186 ALA D N   1 
ATOM   1634 C CA  . ALA D 1 32 ? 14.339 -19.264 -1.679  1.00 26.05 ? 186 ALA D CA  1 
ATOM   1635 C C   . ALA D 1 32 ? 13.903 -19.456 -0.234  1.00 26.72 ? 186 ALA D C   1 
ATOM   1636 O O   . ALA D 1 32 ? 13.410 -18.497 0.374   1.00 26.89 ? 186 ALA D O   1 
ATOM   1637 C CB  . ALA D 1 32 ? 13.265 -19.818 -2.603  1.00 26.73 ? 186 ALA D CB  1 
ATOM   1638 N N   . MET D 1 33 ? 14.069 -20.680 0.332   1.00 25.76 ? 187 MET D N   1 
ATOM   1639 C CA  . MET D 1 33 ? 13.687 -20.946 1.720   1.00 25.45 ? 187 MET D CA  1 
ATOM   1640 C C   . MET D 1 33 ? 14.571 -20.169 2.692   1.00 25.54 ? 187 MET D C   1 
ATOM   1641 O O   . MET D 1 33 ? 14.099 -19.649 3.700   1.00 25.19 ? 187 MET D O   1 
ATOM   1642 C CB  . MET D 1 33 ? 13.734 -22.460 2.021   1.00 25.65 ? 187 MET D CB  1 
ATOM   1643 C CG  . MET D 1 33 ? 12.776 -23.315 1.179   1.00 27.00 ? 187 MET D CG  1 
ATOM   1644 S SD  . MET D 1 33 ? 11.037 -22.824 1.359   1.00 32.03 ? 187 MET D SD  1 
ATOM   1645 C CE  . MET D 1 33 ? 10.718 -22.291 -0.139  1.00 32.02 ? 187 MET D CE  1 
ATOM   1646 N N   . ARG D 1 34 ? 15.873 -20.076 2.386   1.00 25.54 ? 188 ARG D N   1 
ATOM   1647 C CA  . ARG D 1 34 ? 16.803 -19.331 3.223   1.00 25.47 ? 188 ARG D CA  1 
ATOM   1648 C C   . ARG D 1 34 ? 16.507 -17.839 3.162   1.00 26.06 ? 188 ARG D C   1 
ATOM   1649 O O   . ARG D 1 34 ? 16.603 -17.168 4.185   1.00 27.40 ? 188 ARG D O   1 
ATOM   1650 C CB  . ARG D 1 34 ? 18.259 -19.641 2.837   1.00 26.91 ? 188 ARG D CB  1 
ATOM   1651 C CG  . ARG D 1 34 ? 18.633 -21.051 3.277   1.00 30.84 ? 188 ARG D CG  1 
ATOM   1652 C CD  . ARG D 1 34 ? 19.808 -21.610 2.519   1.00 35.98 ? 188 ARG D CD  1 
ATOM   1653 N NE  . ARG D 1 34 ? 20.982 -20.768 2.680   1.00 39.17 ? 188 ARG D NE  1 
ATOM   1654 C CZ  . ARG D 1 34 ? 22.059 -20.836 1.898   1.00 41.93 ? 188 ARG D CZ  1 
ATOM   1655 N NH1 . ARG D 1 34 ? 22.120 -21.726 0.911   1.00 43.02 ? 188 ARG D NH1 1 
ATOM   1656 N NH2 . ARG D 1 34 ? 23.080 -20.025 2.100   1.00 37.69 ? 188 ARG D NH2 1 
ATOM   1657 N N   . LEU D 1 35 ? 16.125 -17.326 1.982   1.00 24.89 ? 189 LEU D N   1 
ATOM   1658 C CA  . LEU D 1 35 ? 15.811 -15.922 1.799   1.00 25.47 ? 189 LEU D CA  1 
ATOM   1659 C C   . LEU D 1 35 ? 14.550 -15.538 2.587   1.00 24.91 ? 189 LEU D C   1 
ATOM   1660 O O   . LEU D 1 35 ? 14.550 -14.515 3.270   1.00 24.95 ? 189 LEU D O   1 
ATOM   1661 C CB  . LEU D 1 35 ? 15.649 -15.587 0.309   1.00 27.18 ? 189 LEU D CB  1 
ATOM   1662 C CG  . LEU D 1 35 ? 15.331 -14.118 -0.014  1.00 29.94 ? 189 LEU D CG  1 
ATOM   1663 C CD1 . LEU D 1 35 ? 16.422 -13.171 0.503   1.00 30.91 ? 189 LEU D CD1 1 
ATOM   1664 C CD2 . LEU D 1 35 ? 15.139 -13.908 -1.487  1.00 31.81 ? 189 LEU D CD2 1 
ATOM   1665 N N   . ALA D 1 36 ? 13.517 -16.363 2.539   1.00 24.68 ? 190 ALA D N   1 
ATOM   1666 C CA  . ALA D 1 36 ? 12.282 -16.117 3.298   1.00 25.76 ? 190 ALA D CA  1 
ATOM   1667 C C   . ALA D 1 36 ? 12.588 -16.120 4.801   1.00 26.10 ? 190 ALA D C   1 
ATOM   1668 O O   . ALA D 1 36 ? 12.144 -15.223 5.512   1.00 26.92 ? 190 ALA D O   1 
ATOM   1669 C CB  . ALA D 1 36 ? 11.243 -17.187 2.950   1.00 25.43 ? 190 ALA D CB  1 
ATOM   1670 N N   . HIS D 1 37 ? 13.398 -17.083 5.263   1.00 26.25 ? 191 HIS D N   1 
ATOM   1671 C CA  . HIS D 1 37 ? 13.783 -17.166 6.671   1.00 27.65 ? 191 HIS D CA  1 
ATOM   1672 C C   . HIS D 1 37 ? 14.580 -15.948 7.147   1.00 27.80 ? 191 HIS D C   1 
ATOM   1673 O O   . HIS D 1 37 ? 14.250 -15.354 8.179   1.00 28.50 ? 191 HIS D O   1 
ATOM   1674 C CB  . HIS D 1 37 ? 14.521 -18.489 6.951   1.00 29.98 ? 191 HIS D CB  1 
ATOM   1675 C CG  . HIS D 1 37 ? 15.103 -18.567 8.331   1.00 36.26 ? 191 HIS D CG  1 
ATOM   1676 N ND1 . HIS D 1 37 ? 16.430 -18.291 8.551   1.00 40.45 ? 191 HIS D ND1 1 
ATOM   1677 C CD2 . HIS D 1 37 ? 14.512 -18.835 9.514   1.00 38.65 ? 191 HIS D CD2 1 
ATOM   1678 C CE1 . HIS D 1 37 ? 16.613 -18.417 9.856   1.00 41.19 ? 191 HIS D CE1 1 
ATOM   1679 N NE2 . HIS D 1 37 ? 15.489 -18.740 10.473  1.00 41.02 ? 191 HIS D NE2 1 
ATOM   1680 N N   . GLN D 1 38 ? 15.595 -15.547 6.384   1.00 26.49 ? 192 GLN D N   1 
ATOM   1681 C CA  . GLN D 1 38 ? 16.414 -14.394 6.744   1.00 27.03 ? 192 GLN D CA  1 
ATOM   1682 C C   . GLN D 1 38 ? 15.594 -13.087 6.735   1.00 26.55 ? 192 GLN D C   1 
ATOM   1683 O O   . GLN D 1 38 ? 15.830 -12.200 7.573   1.00 26.87 ? 192 GLN D O   1 
ATOM   1684 C CB  . GLN D 1 38 ? 17.599 -14.261 5.797   1.00 29.70 ? 192 GLN D CB  1 
ATOM   1685 C CG  . GLN D 1 38 ? 18.577 -13.227 6.270   1.00 38.22 ? 192 GLN D CG  1 
ATOM   1686 C CD  . GLN D 1 38 ? 19.943 -13.532 5.749   1.00 48.80 ? 192 GLN D CD  1 
ATOM   1687 O OE1 . GLN D 1 38 ? 20.327 -13.074 4.670   1.00 51.55 ? 192 GLN D OE1 1 
ATOM   1688 N NE2 . GLN D 1 38 ? 20.722 -14.299 6.514   1.00 52.43 ? 192 GLN D NE2 1 
ATOM   1689 N N   . SER D 1 39 ? 14.629 -12.948 5.785   1.00 25.74 ? 193 SER D N   1 
ATOM   1690 C CA  . SER D 1 39 ? 13.796 -11.740 5.739   1.00 26.16 ? 193 SER D CA  1 
ATOM   1691 C C   . SER D 1 39 ? 12.950 -11.647 7.005   1.00 25.63 ? 193 SER D C   1 
ATOM   1692 O O   . SER D 1 39 ? 12.820 -10.571 7.579   1.00 24.89 ? 193 SER D O   1 
ATOM   1693 C CB  . SER D 1 39 ? 12.889 -11.756 4.504   1.00 29.36 ? 193 SER D CB  1 
ATOM   1694 O OG  . SER D 1 39 ? 13.652 -11.713 3.305   1.00 33.32 ? 193 SER D OG  1 
ATOM   1695 N N   . GLU D 1 40 ? 12.400 -12.794 7.450   1.00 25.78 ? 194 GLU D N   1 
ATOM   1696 C CA  . GLU D 1 40 ? 11.598 -12.843 8.679   1.00 25.83 ? 194 GLU D CA  1 
ATOM   1697 C C   . GLU D 1 40 ? 12.477 -12.494 9.871   1.00 26.41 ? 194 GLU D C   1 
ATOM   1698 O O   . GLU D 1 40 ? 12.027 -11.749 10.725  1.00 26.17 ? 194 GLU D O   1 
ATOM   1699 C CB  . GLU D 1 40 ? 10.992 -14.237 8.902   1.00 26.19 ? 194 GLU D CB  1 
ATOM   1700 C CG  . GLU D 1 40 ? 9.840  -14.565 7.978   1.00 26.32 ? 194 GLU D CG  1 
ATOM   1701 C CD  . GLU D 1 40 ? 9.474  -16.041 8.075   1.00 32.84 ? 194 GLU D CD  1 
ATOM   1702 O OE1 . GLU D 1 40 ? 8.282  -16.375 8.163   1.00 35.28 ? 194 GLU D OE1 1 
ATOM   1703 O OE2 . GLU D 1 40 ? 10.409 -16.867 8.067   1.00 37.25 ? 194 GLU D OE2 1 
ATOM   1704 N N   . GLU D 1 41 ? 13.708 -13.029 9.945   1.00 26.25 ? 195 GLU D N   1 
ATOM   1705 C CA  . GLU D 1 41 ? 14.629 -12.719 11.037  1.00 26.27 ? 195 GLU D CA  1 
ATOM   1706 C C   . GLU D 1 41 ? 15.038 -11.241 11.063  1.00 26.02 ? 195 GLU D C   1 
ATOM   1707 O O   . GLU D 1 41 ? 15.131 -10.661 12.151  1.00 26.11 ? 195 GLU D O   1 
ATOM   1708 C CB  . GLU D 1 41 ? 15.875 -13.613 10.991  1.00 30.31 ? 195 GLU D CB  1 
ATOM   1709 C CG  . GLU D 1 41 ? 15.598 -15.093 11.216  1.00 35.00 ? 195 GLU D CG  1 
ATOM   1710 C CD  . GLU D 1 41 ? 15.002 -15.502 12.554  1.00 42.75 ? 195 GLU D CD  1 
ATOM   1711 O OE1 . GLU D 1 41 ? 15.425 -14.974 13.608  1.00 45.45 ? 195 GLU D OE1 1 
ATOM   1712 O OE2 . GLU D 1 41 ? 14.054 -16.316 12.533  1.00 45.09 ? 195 GLU D OE2 1 
ATOM   1713 N N   . LYS D 1 42 ? 15.221 -10.615 9.895   1.00 25.77 ? 196 LYS D N   1 
ATOM   1714 C CA  . LYS D 1 42 ? 15.523 -9.174  9.855   1.00 26.52 ? 196 LYS D CA  1 
ATOM   1715 C C   . LYS D 1 42 ? 14.306 -8.359  10.393  1.00 26.55 ? 196 LYS D C   1 
ATOM   1716 O O   . LYS D 1 42 ? 14.443 -7.459  11.247  1.00 25.89 ? 196 LYS D O   1 
ATOM   1717 C CB  . LYS D 1 42 ? 15.853 -8.722  8.424   1.00 27.86 ? 196 LYS D CB  1 
ATOM   1718 C CG  . LYS D 1 42 ? 16.289 -7.266  8.427   1.00 32.73 ? 196 LYS D CG  1 
ATOM   1719 C CD  . LYS D 1 42 ? 16.425 -6.728  7.054   1.00 38.05 ? 196 LYS D CD  1 
ATOM   1720 C CE  . LYS D 1 42 ? 15.218 -5.953  6.588   1.00 43.44 ? 196 LYS D CE  1 
ATOM   1721 N NZ  . LYS D 1 42 ? 14.819 -6.355  5.208   1.00 46.71 ? 196 LYS D NZ  1 
ATOM   1722 N N   . GLY D 1 43 ? 13.128 -8.751  9.915   1.00 26.46 ? 197 GLY D N   1 
ATOM   1723 C CA  . GLY D 1 43 ? 11.863 -8.168  10.356  1.00 27.56 ? 197 GLY D CA  1 
ATOM   1724 C C   . GLY D 1 43 ? 11.655 -8.329  11.860  1.00 28.44 ? 197 GLY D C   1 
ATOM   1725 O O   . GLY D 1 43 ? 11.208 -7.398  12.515  1.00 28.07 ? 197 GLY D O   1 
ATOM   1726 N N   . ALA D 1 44 ? 11.999 -9.480  12.428  1.00 28.84 ? 198 ALA D N   1 
ATOM   1727 C CA  . ALA D 1 44 ? 11.899 -9.713  13.880  1.00 30.08 ? 198 ALA D CA  1 
ATOM   1728 C C   . ALA D 1 44 ? 12.854 -8.806  14.640  1.00 29.60 ? 198 ALA D C   1 
ATOM   1729 O O   . ALA D 1 44 ? 12.444 -8.254  15.650  1.00 29.77 ? 198 ALA D O   1 
ATOM   1730 C CB  . ALA D 1 44 ? 12.149 -11.157 14.228  1.00 30.33 ? 198 ALA D CB  1 
ATOM   1731 N N   . ALA D 1 45 ? 14.080 -8.575  14.133  1.00 27.98 ? 199 ALA D N   1 
ATOM   1732 C CA  . ALA D 1 45 ? 15.021 -7.666  14.795  1.00 27.63 ? 199 ALA D CA  1 
ATOM   1733 C C   . ALA D 1 45 ? 14.489 -6.219  14.790  1.00 27.77 ? 199 ALA D C   1 
ATOM   1734 O O   . ALA D 1 45 ? 14.560 -5.532  15.801  1.00 28.71 ? 199 ALA D O   1 
ATOM   1735 C CB  . ALA D 1 45 ? 16.375 -7.733  14.112  1.00 27.31 ? 199 ALA D CB  1 
ATOM   1736 N N   . LEU D 1 46 ? 13.891 -5.786  13.677  1.00 27.02 ? 200 LEU D N   1 
ATOM   1737 C CA  . LEU D 1 46 ? 13.332 -4.439  13.575  1.00 27.23 ? 200 LEU D CA  1 
ATOM   1738 C C   . LEU D 1 46 ? 12.118 -4.253  14.496  1.00 27.69 ? 200 LEU D C   1 
ATOM   1739 O O   . LEU D 1 46 ? 11.916 -3.169  15.017  1.00 26.77 ? 200 LEU D O   1 
ATOM   1740 C CB  . LEU D 1 46 ? 12.980 -4.093  12.119  1.00 27.40 ? 200 LEU D CB  1 
ATOM   1741 C CG  . LEU D 1 46 ? 14.188 -4.014  11.174  1.00 27.74 ? 200 LEU D CG  1 
ATOM   1742 C CD1 . LEU D 1 46 ? 13.789 -3.962  9.732   1.00 28.30 ? 200 LEU D CD1 1 
ATOM   1743 C CD2 . LEU D 1 46 ? 15.097 -2.850  11.563  1.00 26.93 ? 200 LEU D CD2 1 
ATOM   1744 N N   . MET D 1 47 ? 11.332 -5.320  14.706  1.00 28.79 ? 201 MET D N   1 
ATOM   1745 C CA  . MET D 1 47 ? 10.169 -5.297  15.601  1.00 30.64 ? 201 MET D CA  1 
ATOM   1746 C C   . MET D 1 47 ? 10.696 -5.224  17.036  1.00 31.14 ? 201 MET D C   1 
ATOM   1747 O O   . MET D 1 47 ? 10.158 -4.453  17.820  1.00 30.92 ? 201 MET D O   1 
ATOM   1748 C CB  . MET D 1 47 ? 9.331  -6.572  15.472  1.00 32.67 ? 201 MET D CB  1 
ATOM   1749 C CG  . MET D 1 47 ? 8.368  -6.621  14.289  1.00 37.74 ? 201 MET D CG  1 
ATOM   1750 S SD  . MET D 1 47 ? 7.661  -8.290  14.005  1.00 51.50 ? 201 MET D SD  1 
ATOM   1751 C CE  . MET D 1 47 ? 7.291  -8.872  15.710  1.00 54.13 ? 201 MET D CE  1 
ATOM   1752 N N   . ARG D 1 48 ? 11.771 -5.971  17.392  1.00 31.59 ? 202 ARG D N   1 
ATOM   1753 C CA  . ARG D 1 48 ? 12.338 -5.871  18.741  1.00 32.46 ? 202 ARG D CA  1 
ATOM   1754 C C   . ARG D 1 48 ? 12.814 -4.430  19.000  1.00 32.26 ? 202 ARG D C   1 
ATOM   1755 O O   . ARG D 1 48 ? 12.479 -3.845  20.026  1.00 32.66 ? 202 ARG D O   1 
ATOM   1756 C CB  . ARG D 1 48 ? 13.451 -6.895  18.988  1.00 35.44 ? 202 ARG D CB  1 
ATOM   1757 C CG  . ARG D 1 48 ? 14.093 -6.688  20.355  1.00 43.43 ? 202 ARG D CG  1 
ATOM   1758 C CD  . ARG D 1 48 ? 14.602 -7.935  21.051  1.00 49.89 ? 202 ARG D CD  1 
ATOM   1759 N NE  . ARG D 1 48 ? 14.942 -7.618  22.443  1.00 55.18 ? 202 ARG D NE  1 
ATOM   1760 C CZ  . ARG D 1 48 ? 14.196 -7.960  23.492  1.00 59.99 ? 202 ARG D CZ  1 
ATOM   1761 N NH1 . ARG D 1 48 ? 13.086 -8.671  23.324  1.00 60.22 ? 202 ARG D NH1 1 
ATOM   1762 N NH2 . ARG D 1 48 ? 14.582 -7.637  24.722  1.00 60.90 ? 202 ARG D NH2 1 
ATOM   1763 N N   . ASN D 1 49 ? 13.465 -3.828  18.008  1.00 31.49 ? 203 ASN D N   1 
ATOM   1764 C CA  . ASN D 1 49 ? 13.934 -2.449  18.075  1.00 31.42 ? 203 ASN D CA  1 
ATOM   1765 C C   . ASN D 1 49 ? 12.777 -1.451  18.376  1.00 31.62 ? 203 ASN D C   1 
ATOM   1766 O O   . ASN D 1 49 ? 12.922 -0.559  19.210  1.00 31.76 ? 203 ASN D O   1 
ATOM   1767 C CB  . ASN D 1 49 ? 14.660 -2.099  16.782  1.00 32.40 ? 203 ASN D CB  1 
ATOM   1768 C CG  . ASN D 1 49 ? 16.021 -2.801  16.667  1.00 33.88 ? 203 ASN D CG  1 
ATOM   1769 O OD1 . ASN D 1 49 ? 16.513 -3.441  17.632  1.00 31.53 ? 203 ASN D OD1 1 
ATOM   1770 N ND2 . ASN D 1 49 ? 16.662 -2.708  15.468  1.00 34.22 ? 203 ASN D ND2 1 
ATOM   1771 N N   . ARG D 1 50 ? 11.638 -1.636  17.726  1.00 31.55 ? 204 ARG D N   1 
ATOM   1772 C CA  . ARG D 1 50 ? 10.459 -0.792  17.970  1.00 32.57 ? 204 ARG D CA  1 
ATOM   1773 C C   . ARG D 1 50 ? 9.987  -0.967  19.432  1.00 33.62 ? 204 ARG D C   1 
ATOM   1774 O O   . ARG D 1 50 ? 9.716  0.030   20.107  1.00 33.08 ? 204 ARG D O   1 
ATOM   1775 C CB  . ARG D 1 50 ? 9.325  -1.173  16.999  1.00 33.43 ? 204 ARG D CB  1 
ATOM   1776 C CG  . ARG D 1 50 ? 7.963  -0.550  17.334  1.00 37.68 ? 204 ARG D CG  1 
ATOM   1777 C CD  . ARG D 1 50 ? 6.819  -1.367  16.766  1.00 41.68 ? 204 ARG D CD  1 
ATOM   1778 N NE  . ARG D 1 50 ? 6.733  -2.685  17.397  1.00 45.71 ? 204 ARG D NE  1 
ATOM   1779 C CZ  . ARG D 1 50 ? 6.166  -3.750  16.838  1.00 48.87 ? 204 ARG D CZ  1 
ATOM   1780 N NH1 . ARG D 1 50 ? 6.163  -4.918  17.473  1.00 49.28 ? 204 ARG D NH1 1 
ATOM   1781 N NH2 . ARG D 1 50 ? 5.650  -3.674  15.613  1.00 48.74 ? 204 ARG D NH2 1 
ATOM   1782 N N   . ASP D 1 51 ? 9.940  -2.221  19.927  1.00 35.08 ? 205 ASP D N   1 
ATOM   1783 C CA  . ASP D 1 51 ? 9.517  -2.530  21.302  1.00 37.00 ? 205 ASP D CA  1 
ATOM   1784 C C   . ASP D 1 51 ? 10.460 -1.928  22.331  1.00 37.68 ? 205 ASP D C   1 
ATOM   1785 O O   . ASP D 1 51 ? 10.005 -1.436  23.355  1.00 38.31 ? 205 ASP D O   1 
ATOM   1786 C CB  . ASP D 1 51 ? 9.397  -4.045  21.511  1.00 39.51 ? 205 ASP D CB  1 
ATOM   1787 C CG  . ASP D 1 51 ? 8.263  -4.695  20.746  1.00 46.42 ? 205 ASP D CG  1 
ATOM   1788 O OD1 . ASP D 1 51 ? 7.348  -3.961  20.294  1.00 47.26 ? 205 ASP D OD1 1 
ATOM   1789 O OD2 . ASP D 1 51 ? 8.281  -5.942  20.603  1.00 49.15 ? 205 ASP D OD2 1 
ATOM   1790 N N   . LEU D 1 52 ? 11.762 -1.972  22.073  1.00 37.88 ? 206 LEU D N   1 
ATOM   1791 C CA  . LEU D 1 52 ? 12.753 -1.386  22.972  1.00 38.97 ? 206 LEU D CA  1 
ATOM   1792 C C   . LEU D 1 52 ? 12.636 0.140   22.974  1.00 38.90 ? 206 LEU D C   1 
ATOM   1793 O O   . LEU D 1 52 ? 12.712 0.746   24.045  1.00 39.69 ? 206 LEU D O   1 
ATOM   1794 C CB  . LEU D 1 52 ? 14.175 -1.789  22.576  1.00 40.01 ? 206 LEU D CB  1 
ATOM   1795 C CG  . LEU D 1 52 ? 14.545 -3.256  22.721  1.00 43.07 ? 206 LEU D CG  1 
ATOM   1796 C CD1 . LEU D 1 52 ? 15.939 -3.491  22.184  1.00 43.79 ? 206 LEU D CD1 1 
ATOM   1797 C CD2 . LEU D 1 52 ? 14.489 -3.697  24.165  1.00 44.83 ? 206 LEU D CD2 1 
ATOM   1798 N N   . GLN D 1 53 ? 12.438 0.763   21.795  1.00 37.71 ? 207 GLN D N   1 
ATOM   1799 C CA  . GLN D 1 53 ? 12.257 2.217   21.728  1.00 38.36 ? 207 GLN D CA  1 
ATOM   1800 C C   . GLN D 1 53 ? 11.004 2.643   22.512  1.00 40.03 ? 207 GLN D C   1 
ATOM   1801 O O   . GLN D 1 53 ? 11.028 3.664   23.189  1.00 40.71 ? 207 GLN D O   1 
ATOM   1802 C CB  . GLN D 1 53 ? 12.195 2.705   20.268  1.00 38.90 ? 207 GLN D CB  1 
ATOM   1803 C CG  . GLN D 1 53 ? 12.162 4.223   20.108  1.00 39.52 ? 207 GLN D CG  1 
ATOM   1804 C CD  . GLN D 1 53 ? 13.362 4.900   20.739  1.00 40.43 ? 207 GLN D CD  1 
ATOM   1805 O OE1 . GLN D 1 53 ? 14.516 4.674   20.365  1.00 37.32 ? 207 GLN D OE1 1 
ATOM   1806 N NE2 . GLN D 1 53 ? 13.107 5.753   21.716  1.00 42.09 ? 207 GLN D NE2 1 
ATOM   1807 N N   . LEU D 1 54 ? 9.956  1.798   22.487  1.00 40.82 ? 208 LEU D N   1 
ATOM   1808 C CA  . LEU D 1 54 ? 8.714  1.960   23.230  1.00 42.71 ? 208 LEU D CA  1 
ATOM   1809 C C   . LEU D 1 54 ? 8.991  1.946   24.737  1.00 43.64 ? 208 LEU D C   1 
ATOM   1810 O O   . LEU D 1 54 ? 8.503  2.827   25.437  1.00 43.65 ? 208 LEU D O   1 
ATOM   1811 C CB  . LEU D 1 54 ? 7.739  0.816   22.864  1.00 43.81 ? 208 LEU D CB  1 
ATOM   1812 C CG  . LEU D 1 54 ? 6.327  1.119   22.317  1.00 46.92 ? 208 LEU D CG  1 
ATOM   1813 C CD1 . LEU D 1 54 ? 5.998  2.639   22.203  1.00 47.66 ? 208 LEU D CD1 1 
ATOM   1814 C CD2 . LEU D 1 54 ? 6.069  0.362   21.023  1.00 47.73 ? 208 LEU D CD2 1 
ATOM   1815 N N   . GLU D 1 55 ? 9.794  0.975   25.230  1.00 44.04 ? 209 GLU D N   1 
ATOM   1816 C CA  . GLU D 1 55 ? 10.165 0.865   26.649  1.00 45.25 ? 209 GLU D CA  1 
ATOM   1817 C C   . GLU D 1 55 ? 10.987 2.076   27.097  1.00 45.96 ? 209 GLU D C   1 
ATOM   1818 O O   . GLU D 1 55 ? 10.833 2.541   28.228  1.00 46.41 ? 209 GLU D O   1 
ATOM   1819 C CB  . GLU D 1 55 ? 11.010 -0.387  26.894  1.00 48.02 ? 209 GLU D CB  1 
ATOM   1820 C CG  . GLU D 1 55 ? 10.271 -1.703  26.757  1.00 53.94 ? 209 GLU D CG  1 
ATOM   1821 C CD  . GLU D 1 55 ? 11.158 -2.873  27.130  1.00 60.68 ? 209 GLU D CD  1 
ATOM   1822 O OE1 . GLU D 1 55 ? 11.955 -2.727  28.087  1.00 61.62 ? 209 GLU D OE1 1 
ATOM   1823 O OE2 . GLU D 1 55 ? 11.063 -3.932  26.466  1.00 62.51 ? 209 GLU D OE2 1 
ATOM   1824 N N   . ILE D 1 56 ? 11.861 2.578   26.211  1.00 45.28 ? 210 ILE D N   1 
ATOM   1825 C CA  . ILE D 1 56 ? 12.687 3.741   26.484  1.00 45.81 ? 210 ILE D CA  1 
ATOM   1826 C C   . ILE D 1 56 ? 11.804 4.979   26.644  1.00 47.60 ? 210 ILE D C   1 
ATOM   1827 O O   . ILE D 1 56 ? 12.018 5.759   27.569  1.00 47.58 ? 210 ILE D O   1 
ATOM   1828 C CB  . ILE D 1 56 ? 13.743 3.909   25.367  1.00 45.34 ? 210 ILE D CB  1 
ATOM   1829 C CG1 . ILE D 1 56 ? 14.815 2.828   25.488  1.00 45.20 ? 210 ILE D CG1 1 
ATOM   1830 C CG2 . ILE D 1 56 ? 14.384 5.301   25.378  1.00 45.65 ? 210 ILE D CG2 1 
ATOM   1831 C CD1 . ILE D 1 56 ? 15.656 2.703   24.300  1.00 45.77 ? 210 ILE D CD1 1 
ATOM   1832 N N   . ASP D 1 57 ? 10.800 5.131   25.768  1.00 48.86 ? 211 ASP D N   1 
ATOM   1833 C CA  . ASP D 1 57 ? 9.866  6.258   25.783  1.00 51.03 ? 211 ASP D CA  1 
ATOM   1834 C C   . ASP D 1 57 ? 9.092  6.334   27.089  1.00 53.94 ? 211 ASP D C   1 
ATOM   1835 O O   . ASP D 1 57 ? 8.858  7.429   27.598  1.00 54.34 ? 211 ASP D O   1 
ATOM   1836 C CB  . ASP D 1 57 ? 8.862  6.133   24.623  1.00 51.80 ? 211 ASP D CB  1 
ATOM   1837 C CG  . ASP D 1 57 ? 9.474  6.302   23.250  1.00 54.19 ? 211 ASP D CG  1 
ATOM   1838 O OD1 . ASP D 1 57 ? 8.839  5.871   22.263  1.00 54.34 ? 211 ASP D OD1 1 
ATOM   1839 O OD2 . ASP D 1 57 ? 10.593 6.859   23.163  1.00 55.63 ? 211 ASP D OD2 1 
ATOM   1840 N N   . GLN D 1 58 ? 8.688  5.170   27.625  1.00 55.70 ? 212 GLN D N   1 
ATOM   1841 C CA  . GLN D 1 58 ? 7.922  5.093   28.863  1.00 57.93 ? 212 GLN D CA  1 
ATOM   1842 C C   . GLN D 1 58 ? 8.772  5.410   30.100  1.00 59.22 ? 212 GLN D C   1 
ATOM   1843 O O   . GLN D 1 58 ? 8.247  5.936   31.084  1.00 59.93 ? 212 GLN D O   1 
ATOM   1844 C CB  . GLN D 1 58 ? 7.243  3.722   28.980  1.00 60.38 ? 212 GLN D CB  1 
ATOM   1845 C CG  . GLN D 1 58 ? 6.186  3.500   27.881  1.00 65.15 ? 212 GLN D CG  1 
ATOM   1846 C CD  . GLN D 1 58 ? 5.761  2.056   27.679  1.00 71.53 ? 212 GLN D CD  1 
ATOM   1847 O OE1 . GLN D 1 58 ? 5.127  1.700   26.667  1.00 73.09 ? 212 GLN D OE1 1 
ATOM   1848 N NE2 . GLN D 1 58 ? 6.095  1.185   28.625  1.00 73.06 ? 212 GLN D NE2 1 
ATOM   1849 N N   . LEU D 1 59 ? 10.079 5.127   30.044  1.00 59.24 ? 213 LEU D N   1 
ATOM   1850 C CA  . LEU D 1 59 ? 10.980 5.393   31.162  1.00 60.17 ? 213 LEU D CA  1 
ATOM   1851 C C   . LEU D 1 59 ? 11.601 6.792   31.110  1.00 61.08 ? 213 LEU D C   1 
ATOM   1852 O O   . LEU D 1 59 ? 11.949 7.338   32.147  1.00 61.48 ? 213 LEU D O   1 
ATOM   1853 C CB  . LEU D 1 59 ? 12.088 4.334   31.218  1.00 60.47 ? 213 LEU D CB  1 
ATOM   1854 C CG  . LEU D 1 59 ? 11.617 2.892   31.382  1.00 62.22 ? 213 LEU D CG  1 
ATOM   1855 C CD1 . LEU D 1 59 ? 12.781 1.932   31.259  1.00 62.94 ? 213 LEU D CD1 1 
ATOM   1856 C CD2 . LEU D 1 59 ? 10.877 2.689   32.701  1.00 62.76 ? 213 LEU D CD2 1 
ATOM   1857 N N   . LYS D 1 60 ? 11.739 7.373   29.918  1.00 61.33 ? 214 LYS D N   1 
ATOM   1858 C CA  . LYS D 1 60 ? 12.337 8.693   29.738  1.00 62.23 ? 214 LYS D CA  1 
ATOM   1859 C C   . LYS D 1 60 ? 11.365 9.806   30.148  1.00 63.12 ? 214 LYS D C   1 
ATOM   1860 O O   . LYS D 1 60 ? 11.001 9.919   31.319  1.00 63.41 ? 214 LYS D O   1 
ATOM   1861 C CB  . LYS D 1 60 ? 12.756 8.876   28.268  1.00 63.87 ? 214 LYS D CB  1 
ATOM   1862 C CG  . LYS D 1 60 ? 14.103 9.555   28.075  1.00 67.44 ? 214 LYS D CG  1 
ATOM   1863 C CD  . LYS D 1 60 ? 14.651 9.337   26.658  1.00 72.03 ? 214 LYS D CD  1 
ATOM   1864 C CE  . LYS D 1 60 ? 13.742 9.878   25.574  1.00 75.77 ? 214 LYS D CE  1 
ATOM   1865 N NZ  . LYS D 1 60 ? 14.412 9.893   24.245  1.00 77.68 ? 214 LYS D NZ  1 
HETATM 1866 O O   . HOH E 2 .  ? 6.871  10.633  5.004   1.00 49.06 ? 301 HOH A O   1 
HETATM 1867 O O   . HOH E 2 .  ? 3.572  -27.797 8.715   1.00 31.72 ? 302 HOH A O   1 
HETATM 1868 O O   . HOH E 2 .  ? -2.340 10.362  13.806  1.00 49.75 ? 303 HOH A O   1 
HETATM 1869 O O   . HOH E 2 .  ? -1.146 4.809   15.698  1.00 38.56 ? 304 HOH A O   1 
HETATM 1870 O O   . HOH E 2 .  ? 0.073  -10.448 13.800  1.00 58.94 ? 305 HOH A O   1 
HETATM 1871 O O   . HOH E 2 .  ? -1.237 -17.884 3.575   1.00 28.71 ? 306 HOH A O   1 
HETATM 1872 O O   . HOH E 2 .  ? 4.250  -4.779  12.614  1.00 32.75 ? 307 HOH A O   1 
HETATM 1873 O O   . HOH E 2 .  ? -4.363 -13.335 13.907  1.00 36.57 ? 308 HOH A O   1 
HETATM 1874 O O   . HOH E 2 .  ? 5.535  -25.105 11.516  1.00 28.40 ? 309 HOH A O   1 
HETATM 1875 O O   . HOH E 2 .  ? -0.206 -29.211 3.664   1.00 52.26 ? 310 HOH A O   1 
HETATM 1876 O O   . HOH E 2 .  ? -0.738 21.570  7.795   1.00 76.59 ? 311 HOH A O   1 
HETATM 1877 O O   . HOH E 2 .  ? 6.367  6.768   5.341   1.00 39.34 ? 312 HOH A O   1 
HETATM 1878 O O   . HOH E 2 .  ? -2.512 -1.333  6.642   1.00 30.70 ? 313 HOH A O   1 
HETATM 1879 O O   . HOH E 2 .  ? -0.810 -17.481 10.613  1.00 30.15 ? 314 HOH A O   1 
HETATM 1880 O O   . HOH E 2 .  ? -0.518 2.486   3.704   1.00 50.45 ? 315 HOH A O   1 
HETATM 1881 O O   . HOH E 2 .  ? 10.400 -23.548 8.775   1.00 39.63 ? 316 HOH A O   1 
HETATM 1882 O O   . HOH E 2 .  ? 4.163  7.857   4.841   1.00 55.85 ? 317 HOH A O   1 
HETATM 1883 O O   . HOH E 2 .  ? 2.831  9.212   17.989  1.00 53.46 ? 318 HOH A O   1 
HETATM 1884 O O   . HOH E 2 .  ? 5.218  -37.234 11.158  1.00 45.27 ? 319 HOH A O   1 
HETATM 1885 O O   . HOH E 2 .  ? 10.533 -23.168 4.768   1.00 51.85 ? 320 HOH A O   1 
HETATM 1886 O O   . HOH E 2 .  ? 7.908  -27.956 7.657   1.00 35.27 ? 321 HOH A O   1 
HETATM 1887 O O   . HOH E 2 .  ? 8.450  -12.111 13.396  1.00 46.85 ? 322 HOH A O   1 
HETATM 1888 O O   . HOH E 2 .  ? 8.259  8.412   5.103   1.00 50.08 ? 323 HOH A O   1 
HETATM 1889 O O   . HOH F 2 .  ? 0.875  -18.891 -3.468  1.00 64.20 ? 301 HOH B O   1 
HETATM 1890 O O   . HOH F 2 .  ? 6.064  -15.356 -5.760  1.00 41.23 ? 302 HOH B O   1 
HETATM 1891 O O   . HOH F 2 .  ? 9.351  1.128   14.096  1.00 35.11 ? 303 HOH B O   1 
HETATM 1892 O O   . HOH F 2 .  ? 6.671  -0.731  3.347   1.00 34.54 ? 304 HOH B O   1 
HETATM 1893 O O   . HOH F 2 .  ? 2.031  -20.789 -3.997  1.00 41.06 ? 305 HOH B O   1 
HETATM 1894 O O   . HOH F 2 .  ? 10.447 -11.725 -3.009  1.00 36.00 ? 306 HOH B O   1 
HETATM 1895 O O   . HOH F 2 .  ? 13.914 11.430  10.893  1.00 38.63 ? 307 HOH B O   1 
HETATM 1896 O O   . HOH F 2 .  ? 12.473 2.059   5.039   1.00 43.94 ? 308 HOH B O   1 
HETATM 1897 O O   . HOH F 2 .  ? -1.832 -17.809 -1.016  1.00 36.12 ? 309 HOH B O   1 
HETATM 1898 O O   . HOH F 2 .  ? 6.376  1.161   14.181  1.00 36.11 ? 310 HOH B O   1 
HETATM 1899 O O   . HOH F 2 .  ? 7.421  5.016   15.516  1.00 49.27 ? 311 HOH B O   1 
HETATM 1900 O O   . HOH F 2 .  ? 10.127 8.179   6.946   1.00 37.41 ? 312 HOH B O   1 
HETATM 1901 O O   . HOH F 2 .  ? 0.986  -11.534 -0.548  1.00 43.24 ? 313 HOH B O   1 
HETATM 1902 O O   . HOH F 2 .  ? 13.692 4.075   5.975   1.00 44.66 ? 314 HOH B O   1 
HETATM 1903 O O   . HOH F 2 .  ? 7.393  -54.418 -2.207  1.00 40.53 ? 315 HOH B O   1 
HETATM 1904 O O   . HOH F 2 .  ? -2.208 -19.363 -3.224  1.00 30.87 ? 316 HOH B O   1 
HETATM 1905 O O   . HOH G 2 .  ? 24.112 -18.678 -10.807 1.00 42.89 ? 301 HOH C O   1 
HETATM 1906 O O   . HOH G 2 .  ? 23.371 -14.887 4.507   1.00 36.29 ? 302 HOH C O   1 
HETATM 1907 O O   . HOH G 2 .  ? 21.154 -22.556 -21.028 1.00 44.83 ? 303 HOH C O   1 
HETATM 1908 O O   . HOH G 2 .  ? 22.870 -13.652 8.354   1.00 30.17 ? 304 HOH C O   1 
HETATM 1909 O O   . HOH G 2 .  ? 18.747 -2.760  9.126   1.00 34.23 ? 305 HOH C O   1 
HETATM 1910 O O   . HOH G 2 .  ? 17.176 -22.227 -25.929 1.00 51.40 ? 306 HOH C O   1 
HETATM 1911 O O   . HOH G 2 .  ? 22.201 -17.437 -16.836 1.00 38.72 ? 307 HOH C O   1 
HETATM 1912 O O   . HOH G 2 .  ? 13.813 -32.409 -38.029 1.00 32.71 ? 308 HOH C O   1 
HETATM 1913 O O   . HOH G 2 .  ? 14.414 -25.998 -35.672 1.00 40.52 ? 309 HOH C O   1 
HETATM 1914 O O   . HOH G 2 .  ? 18.608 -28.296 -22.910 1.00 42.74 ? 310 HOH C O   1 
HETATM 1915 O O   . HOH G 2 .  ? 12.292 -23.270 -29.019 1.00 40.00 ? 311 HOH C O   1 
HETATM 1916 O O   . HOH G 2 .  ? 22.178 3.216   17.187  1.00 40.47 ? 312 HOH C O   1 
HETATM 1917 O O   . HOH G 2 .  ? 10.635 -24.626 -27.016 1.00 41.13 ? 313 HOH C O   1 
HETATM 1918 O O   . HOH G 2 .  ? 9.079  -35.957 -42.299 1.00 46.68 ? 314 HOH C O   1 
HETATM 1919 O O   . HOH G 2 .  ? 18.006 -4.908  31.520  1.00 63.30 ? 315 HOH C O   1 
HETATM 1920 O O   . HOH G 2 .  ? 24.611 -15.445 -0.143  1.00 26.85 ? 316 HOH C O   1 
HETATM 1921 O O   . HOH G 2 .  ? 25.412 -6.899  14.558  1.00 26.07 ? 317 HOH C O   1 
HETATM 1922 O O   . HOH G 2 .  ? 26.760 2.402   17.445  1.00 62.00 ? 318 HOH C O   1 
HETATM 1923 O O   . HOH G 2 .  ? 16.457 -17.798 -20.896 1.00 37.66 ? 319 HOH C O   1 
HETATM 1924 O O   . HOH G 2 .  ? 18.420 -24.026 -34.906 1.00 40.41 ? 320 HOH C O   1 
HETATM 1925 O O   . HOH G 2 .  ? 29.384 -4.150  16.326  1.00 60.18 ? 321 HOH C O   1 
HETATM 1926 O O   . HOH G 2 .  ? 12.317 -20.320 -19.652 1.00 45.66 ? 322 HOH C O   1 
HETATM 1927 O O   . HOH G 2 .  ? 12.249 -10.038 -1.041  1.00 46.83 ? 323 HOH C O   1 
HETATM 1928 O O   . HOH G 2 .  ? 10.966 -37.949 -41.671 1.00 43.68 ? 324 HOH C O   1 
HETATM 1929 O O   . HOH G 2 .  ? 24.890 -6.255  -0.020  1.00 45.85 ? 325 HOH C O   1 
HETATM 1930 O O   . HOH G 2 .  ? 17.575 -8.370  -0.154  1.00 38.62 ? 326 HOH C O   1 
HETATM 1931 O O   . HOH G 2 .  ? 15.307 -9.393  -0.942  1.00 36.94 ? 327 HOH C O   1 
HETATM 1932 O O   . HOH G 2 .  ? 13.123 -24.633 -33.219 1.00 36.22 ? 328 HOH C O   1 
HETATM 1933 O O   . HOH G 2 .  ? 25.195 -8.750  -1.746  1.00 45.67 ? 329 HOH C O   1 
HETATM 1934 O O   . HOH G 2 .  ? 21.258 -7.540  19.366  1.00 45.69 ? 330 HOH C O   1 
HETATM 1935 O O   . HOH G 2 .  ? 4.793  -36.250 -38.851 1.00 40.38 ? 331 HOH C O   1 
HETATM 1936 O O   . HOH G 2 .  ? 22.781 -21.577 -18.913 1.00 42.90 ? 332 HOH C O   1 
HETATM 1937 O O   . HOH G 2 .  ? 11.534 -11.607 -7.060  1.00 53.09 ? 333 HOH C O   1 
HETATM 1938 O O   . HOH G 2 .  ? 18.348 -0.793  11.391  1.00 40.16 ? 334 HOH C O   1 
HETATM 1939 O O   . HOH G 2 .  ? 25.265 -15.209 2.631   1.00 30.28 ? 335 HOH C O   1 
HETATM 1940 O O   . HOH G 2 .  ? 17.577 -17.932 -23.510 1.00 43.63 ? 336 HOH C O   1 
HETATM 1941 O O   . HOH H 2 .  ? 17.071 -24.081 2.758   1.00 36.34 ? 301 HOH D O   1 
HETATM 1942 O O   . HOH H 2 .  ? 14.507 -32.484 -7.818  1.00 47.91 ? 302 HOH D O   1 
HETATM 1943 O O   . HOH H 2 .  ? 16.073 -11.647 14.320  1.00 49.41 ? 303 HOH D O   1 
HETATM 1944 O O   . HOH H 2 .  ? 15.325 -31.389 -15.550 1.00 42.00 ? 304 HOH D O   1 
HETATM 1945 O O   . HOH H 2 .  ? 12.914 -23.937 -7.448  1.00 42.88 ? 305 HOH D O   1 
HETATM 1946 O O   . HOH H 2 .  ? 20.430 -32.838 -8.471  1.00 54.87 ? 306 HOH D O   1 
HETATM 1947 O O   . HOH H 2 .  ? 12.139 -20.812 5.062   1.00 31.70 ? 307 HOH D O   1 
HETATM 1948 O O   . HOH H 2 .  ? 11.744 -15.049 12.900  1.00 57.88 ? 308 HOH D O   1 
HETATM 1949 O O   . HOH H 2 .  ? 20.218 -33.733 -40.547 1.00 35.96 ? 309 HOH D O   1 
HETATM 1950 O O   . HOH H 2 .  ? 21.230 -23.661 -2.428  1.00 42.40 ? 310 HOH D O   1 
HETATM 1951 O O   . HOH H 2 .  ? 23.526 -18.897 4.528   1.00 44.57 ? 311 HOH D O   1 
HETATM 1952 O O   . HOH H 2 .  ? 17.194 -31.322 -37.499 1.00 54.34 ? 312 HOH D O   1 
HETATM 1953 O O   . HOH H 2 .  ? 9.412  -11.013 11.098  1.00 36.99 ? 313 HOH D O   1 
HETATM 1954 O O   . HOH H 2 .  ? 8.588  2.286   19.020  1.00 44.23 ? 314 HOH D O   1 
HETATM 1955 O O   . HOH H 2 .  ? 14.863 -30.240 -9.094  1.00 40.04 ? 315 HOH D O   1 
HETATM 1956 O O   . HOH H 2 .  ? 19.274 -15.914 8.312   1.00 43.99 ? 316 HOH D O   1 
HETATM 1957 O O   . HOH H 2 .  ? 26.924 -38.605 -32.019 1.00 41.12 ? 317 HOH D O   1 
HETATM 1958 O O   . HOH H 2 .  ? 25.658 -19.416 1.105   1.00 32.02 ? 318 HOH D O   1 
HETATM 1959 O O   . HOH H 2 .  ? 27.005 -34.109 -34.394 1.00 50.69 ? 319 HOH D O   1 
HETATM 1960 O O   . HOH H 2 .  ? 20.369 -33.838 -11.569 1.00 44.87 ? 320 HOH D O   1 
HETATM 1961 O O   . HOH H 2 .  ? 10.353 -9.646  17.130  1.00 52.47 ? 321 HOH D O   1 
HETATM 1962 O O   . HOH H 2 .  ? 22.974 -34.299 -10.665 1.00 60.37 ? 322 HOH D O   1 
HETATM 1963 O O   . HOH H 2 .  ? 11.776 -21.280 -9.886  1.00 45.53 ? 323 HOH D O   1 
HETATM 1964 O O   . HOH H 2 .  ? 13.921 -29.823 -14.022 1.00 45.04 ? 324 HOH D O   1 
HETATM 1965 O O   . HOH H 2 .  ? 22.104 -17.152 5.671   1.00 41.15 ? 325 HOH D O   1 
HETATM 1966 O O   . HOH H 2 .  ? 20.113 -41.651 -41.623 1.00 32.87 ? 326 HOH D O   1 
HETATM 1967 O O   . HOH H 2 .  ? 25.092 -31.942 -32.827 1.00 55.65 ? 327 HOH D O   1 
HETATM 1968 O O   . HOH H 2 .  ? 26.016 -21.914 0.353   1.00 42.38 ? 328 HOH D O   1 
HETATM 1969 O O   . HOH H 2 .  ? 16.474 -21.528 6.276   1.00 38.35 ? 329 HOH D O   1 
HETATM 1970 O O   . HOH H 2 .  ? 13.390 -30.618 -11.383 1.00 53.53 ? 330 HOH D O   1 
HETATM 1971 O O   . HOH H 2 .  ? 23.364 -23.153 -3.466  1.00 45.86 ? 331 HOH D O   1 
# 
