data_9AV0
# 
_entry.id   9AV0 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.400 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9AV0         pdb_00009av0 10.2210/pdb9av0/pdb 
WWPDB D_1000282047 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2024-11-27 
2 'Structure model' 1 1 2025-01-15 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9AV0 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-01 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              sethh@gene.com 
_pdbx_contact_author.name_first         Seth 
_pdbx_contact_author.name_last          Harris 
_pdbx_contact_author.name_mi            F 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-1728-9771 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Harris, S.F.' 1 0000-0003-1728-9771 
'Wu, P.'       2 ?                   
# 
loop_
_citation.abstract 
_citation.abstract_id_CAS 
_citation.book_id_ISBN 
_citation.book_publisher 
_citation.book_publisher_city 
_citation.book_title 
_citation.coordinate_linkage 
_citation.country 
_citation.database_id_Medline 
_citation.details 
_citation.id 
_citation.journal_abbrev 
_citation.journal_id_ASTM 
_citation.journal_id_CSD 
_citation.journal_id_ISSN 
_citation.journal_full 
_citation.journal_issue 
_citation.journal_volume 
_citation.language 
_citation.page_first 
_citation.page_last 
_citation.title 
_citation.year 
_citation.database_id_CSD 
_citation.pdbx_database_id_DOI 
_citation.pdbx_database_id_PubMed 
_citation.pdbx_database_id_patent 
_citation.unpublished_flag 
? ? ? ? ? ? ? US ? ? primary Mbio                  ?      ?    2150-7511 ? ? 15 ? e0089724 e0089724 
'Discovery of GuaB inhibitors with efficacy against Acinetobacter baumannii infection.'                2024 ? 
10.1128/mbio.00897-24      39207111 ? ? 
? ? ? ? ? ? ? UK ? ? 1       Bioorg.Med.Chem.Lett. BMCLE8 1127 1464-3405 ? ? ?  ? 130026   130026   
'Discovery of potent dihydro-oxazinoquinolinone inhibitors of GuaB for the treatment of tuberculosis.' 2024 ? 
10.1016/j.bmcl.2024.130026 39536836 ? ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kofoed, E.M.'    1  0000-0002-1779-4914 
primary 'Aliagas, I.'     2  ?                   
primary 'Crawford, T.'    3  ?                   
primary 'Mao, J.'         4  ?                   
primary 'Harris, S.F.'    5  ?                   
primary 'Xu, M.'          6  ?                   
primary 'Wang, S.'        7  ?                   
primary 'Wu, P.'          8  ?                   
primary 'Ma, F.'          9  ?                   
primary 'Clark, K.'       10 ?                   
primary 'Sims, J.'        11 ?                   
primary 'Xu, Y.'          12 ?                   
primary 'Peng, Y.'        13 0000-0002-8663-7330 
primary 'Skippington, E.' 14 ?                   
primary 'Yang, Y.'        15 ?                   
primary 'Reeder, J.'      16 ?                   
primary 'Ubhayakar, S.'   17 ?                   
primary 'Baumgardner, M.' 18 ?                   
primary 'Yan, Z.'         19 ?                   
primary 'Chen, J.'        20 ?                   
primary 'Park, S.'        21 ?                   
primary 'Zhang, H.'       22 ?                   
primary 'Yen, C.-W.'      23 ?                   
primary 'Lorenzo, M.'     24 ?                   
primary 'Skelton, N.'     25 ?                   
primary 'Liang, X.'       26 ?                   
primary 'Chen, L.'        27 ?                   
primary 'Hoag, B.'        28 ?                   
primary 'Li, C.S.'        29 ?                   
primary 'Liu, Z.'         30 ?                   
primary 'Wai, J.'         31 ?                   
primary 'Liu, X.'         32 ?                   
primary 'Liang, J.'       33 ?                   
primary 'Tan, M.W.'       34 0000-0002-7748-212X 
1       'Zhou, Y.'        35 ?                   
1       'Aliagas, I.'     36 ?                   
1       'Wang, S.'        37 ?                   
1       'Li, C.S.'        38 ?                   
1       'Liu, Z.'         39 ?                   
1       'Bowman, C.M.'    40 ?                   
1       'Burdick, D.J.'   41 ?                   
1       'Clark, K.R.'     42 ?                   
1       'Dening, T.J.'    43 ?                   
1       'Flygare, J.'     44 ?                   
1       'Ganti, A.'       45 ?                   
1       'Girgis, H.S.'    46 ?                   
1       'Hanan, E.J.'     47 ?                   
1       'Harris, S.F.'    48 ?                   
1       'Hu, C.'          49 ?                   
1       'Kapadia, S.B.'   50 ?                   
1       'Koehler, M.F.T.' 51 ?                   
1       'Lai, T.'         52 ?                   
1       'Liang, J.'       53 ?                   
1       'Liu, X.'         54 ?                   
1       'Ma, F.'          55 ?                   
1       'Mao, J.'         56 ?                   
1       'Nicolai, J.'     57 ?                   
1       'Sims, J.'        58 ?                   
1       'Unhayaker, S.'   59 ?                   
1       'Wai, J.'         60 ?                   
1       'Wang, X.'        61 ?                   
1       'Wu, P.'          62 ?                   
1       'Xu, Y.'          63 ?                   
1       'Yen, C.W.'       64 ?                   
1       'Zhang, R.'       65 ?                   
1       'Elfert, T.F.'    66 ?                   
1       'Tan, M.W.'       67 ?                   
1       'Kofoed, E.M.'    68 ?                   
1       'Crawford, T.D.'  69 ?                   
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 
;Inosine-5'-monophosphate dehydrogenase
;
40598.129 1  1.1.1.205 ? ? ? 
2 non-polymer syn 'INOSINIC ACID'                                                                                           
348.206   1  ?         ? ? ? 
3 non-polymer syn '9-{(1R)-1-[(5P)-5-(4-chloro-1H-imidazol-2-yl)pyridin-3-yl]ethoxy}-1,4-dihydro-2H-pyrano[3,4-c]quinoline' 
406.865   1  ?         ? ? ? 
4 water       nat water                                                                                                     18.015 
29 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'IMP dehydrogenase,IMPD,IMPDH' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MHHHHHHGENLYFQGSWESKFAKESLTFDDVLLIPAQSDILPKDVDLSVQLSDKVKLNIPVISAGMDTVTESKMAIAMAR
QGGLGVIHKNMGVEEQADEVQKVKRSGGLLVAAAIGISKDTDIRAQKLVEAGVDVLVIDTAHGHSKGVIDQVKHIKKTYP
EITLVAGNVATAEATKDLFEAGADIVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKHGKAIIADGGIKFSGDIIK
ALAAGGHAVMLGSLLAGTEESPGATEIFQGRQYKVYRGMGSLGAMEKGSNDRYFQEDKAPKKFVPEGIEGRTAYKGALQD
TIYQLMGGVRAGMGYTGSHDLRELREEAQFTRMGPAGLAESHPHNIQITKESPNYSFGNS
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MHHHHHHGENLYFQGSWESKFAKESLTFDDVLLIPAQSDILPKDVDLSVQLSDKVKLNIPVISAGMDTVTESKMAIAMAR
QGGLGVIHKNMGVEEQADEVQKVKRSGGLLVAAAIGISKDTDIRAQKLVEAGVDVLVIDTAHGHSKGVIDQVKHIKKTYP
EITLVAGNVATAEATKDLFEAGADIVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKHGKAIIADGGIKFSGDIIK
ALAAGGHAVMLGSLLAGTEESPGATEIFQGRQYKVYRGMGSLGAMEKGSNDRYFQEDKAPKKFVPEGIEGRTAYKGALQD
TIYQLMGGVRAGMGYTGSHDLRELREEAQFTRMGPAGLAESHPHNIQITKESPNYSFGNS
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'INOSINIC ACID'                                                                                           IMP   
3 '9-{(1R)-1-[(5P)-5-(4-chloro-1H-imidazol-2-yl)pyridin-3-yl]ethoxy}-1,4-dihydro-2H-pyrano[3,4-c]quinoline' A1AG0 
4 water                                                                                                     HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   HIS n 
1 3   HIS n 
1 4   HIS n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   GLY n 
1 9   GLU n 
1 10  ASN n 
1 11  LEU n 
1 12  TYR n 
1 13  PHE n 
1 14  GLN n 
1 15  GLY n 
1 16  SER n 
1 17  TRP n 
1 18  GLU n 
1 19  SER n 
1 20  LYS n 
1 21  PHE n 
1 22  ALA n 
1 23  LYS n 
1 24  GLU n 
1 25  SER n 
1 26  LEU n 
1 27  THR n 
1 28  PHE n 
1 29  ASP n 
1 30  ASP n 
1 31  VAL n 
1 32  LEU n 
1 33  LEU n 
1 34  ILE n 
1 35  PRO n 
1 36  ALA n 
1 37  GLN n 
1 38  SER n 
1 39  ASP n 
1 40  ILE n 
1 41  LEU n 
1 42  PRO n 
1 43  LYS n 
1 44  ASP n 
1 45  VAL n 
1 46  ASP n 
1 47  LEU n 
1 48  SER n 
1 49  VAL n 
1 50  GLN n 
1 51  LEU n 
1 52  SER n 
1 53  ASP n 
1 54  LYS n 
1 55  VAL n 
1 56  LYS n 
1 57  LEU n 
1 58  ASN n 
1 59  ILE n 
1 60  PRO n 
1 61  VAL n 
1 62  ILE n 
1 63  SER n 
1 64  ALA n 
1 65  GLY n 
1 66  MET n 
1 67  ASP n 
1 68  THR n 
1 69  VAL n 
1 70  THR n 
1 71  GLU n 
1 72  SER n 
1 73  LYS n 
1 74  MET n 
1 75  ALA n 
1 76  ILE n 
1 77  ALA n 
1 78  MET n 
1 79  ALA n 
1 80  ARG n 
1 81  GLN n 
1 82  GLY n 
1 83  GLY n 
1 84  LEU n 
1 85  GLY n 
1 86  VAL n 
1 87  ILE n 
1 88  HIS n 
1 89  LYS n 
1 90  ASN n 
1 91  MET n 
1 92  GLY n 
1 93  VAL n 
1 94  GLU n 
1 95  GLU n 
1 96  GLN n 
1 97  ALA n 
1 98  ASP n 
1 99  GLU n 
1 100 VAL n 
1 101 GLN n 
1 102 LYS n 
1 103 VAL n 
1 104 LYS n 
1 105 ARG n 
1 106 SER n 
1 107 GLY n 
1 108 GLY n 
1 109 LEU n 
1 110 LEU n 
1 111 VAL n 
1 112 ALA n 
1 113 ALA n 
1 114 ALA n 
1 115 ILE n 
1 116 GLY n 
1 117 ILE n 
1 118 SER n 
1 119 LYS n 
1 120 ASP n 
1 121 THR n 
1 122 ASP n 
1 123 ILE n 
1 124 ARG n 
1 125 ALA n 
1 126 GLN n 
1 127 LYS n 
1 128 LEU n 
1 129 VAL n 
1 130 GLU n 
1 131 ALA n 
1 132 GLY n 
1 133 VAL n 
1 134 ASP n 
1 135 VAL n 
1 136 LEU n 
1 137 VAL n 
1 138 ILE n 
1 139 ASP n 
1 140 THR n 
1 141 ALA n 
1 142 HIS n 
1 143 GLY n 
1 144 HIS n 
1 145 SER n 
1 146 LYS n 
1 147 GLY n 
1 148 VAL n 
1 149 ILE n 
1 150 ASP n 
1 151 GLN n 
1 152 VAL n 
1 153 LYS n 
1 154 HIS n 
1 155 ILE n 
1 156 LYS n 
1 157 LYS n 
1 158 THR n 
1 159 TYR n 
1 160 PRO n 
1 161 GLU n 
1 162 ILE n 
1 163 THR n 
1 164 LEU n 
1 165 VAL n 
1 166 ALA n 
1 167 GLY n 
1 168 ASN n 
1 169 VAL n 
1 170 ALA n 
1 171 THR n 
1 172 ALA n 
1 173 GLU n 
1 174 ALA n 
1 175 THR n 
1 176 LYS n 
1 177 ASP n 
1 178 LEU n 
1 179 PHE n 
1 180 GLU n 
1 181 ALA n 
1 182 GLY n 
1 183 ALA n 
1 184 ASP n 
1 185 ILE n 
1 186 VAL n 
1 187 LYS n 
1 188 VAL n 
1 189 GLY n 
1 190 ILE n 
1 191 GLY n 
1 192 PRO n 
1 193 GLY n 
1 194 SER n 
1 195 ILE n 
1 196 CYS n 
1 197 THR n 
1 198 THR n 
1 199 ARG n 
1 200 VAL n 
1 201 VAL n 
1 202 ALA n 
1 203 GLY n 
1 204 VAL n 
1 205 GLY n 
1 206 VAL n 
1 207 PRO n 
1 208 GLN n 
1 209 ILE n 
1 210 THR n 
1 211 ALA n 
1 212 ILE n 
1 213 TYR n 
1 214 ASP n 
1 215 CYS n 
1 216 ALA n 
1 217 THR n 
1 218 GLU n 
1 219 ALA n 
1 220 ARG n 
1 221 LYS n 
1 222 HIS n 
1 223 GLY n 
1 224 LYS n 
1 225 ALA n 
1 226 ILE n 
1 227 ILE n 
1 228 ALA n 
1 229 ASP n 
1 230 GLY n 
1 231 GLY n 
1 232 ILE n 
1 233 LYS n 
1 234 PHE n 
1 235 SER n 
1 236 GLY n 
1 237 ASP n 
1 238 ILE n 
1 239 ILE n 
1 240 LYS n 
1 241 ALA n 
1 242 LEU n 
1 243 ALA n 
1 244 ALA n 
1 245 GLY n 
1 246 GLY n 
1 247 HIS n 
1 248 ALA n 
1 249 VAL n 
1 250 MET n 
1 251 LEU n 
1 252 GLY n 
1 253 SER n 
1 254 LEU n 
1 255 LEU n 
1 256 ALA n 
1 257 GLY n 
1 258 THR n 
1 259 GLU n 
1 260 GLU n 
1 261 SER n 
1 262 PRO n 
1 263 GLY n 
1 264 ALA n 
1 265 THR n 
1 266 GLU n 
1 267 ILE n 
1 268 PHE n 
1 269 GLN n 
1 270 GLY n 
1 271 ARG n 
1 272 GLN n 
1 273 TYR n 
1 274 LYS n 
1 275 VAL n 
1 276 TYR n 
1 277 ARG n 
1 278 GLY n 
1 279 MET n 
1 280 GLY n 
1 281 SER n 
1 282 LEU n 
1 283 GLY n 
1 284 ALA n 
1 285 MET n 
1 286 GLU n 
1 287 LYS n 
1 288 GLY n 
1 289 SER n 
1 290 ASN n 
1 291 ASP n 
1 292 ARG n 
1 293 TYR n 
1 294 PHE n 
1 295 GLN n 
1 296 GLU n 
1 297 ASP n 
1 298 LYS n 
1 299 ALA n 
1 300 PRO n 
1 301 LYS n 
1 302 LYS n 
1 303 PHE n 
1 304 VAL n 
1 305 PRO n 
1 306 GLU n 
1 307 GLY n 
1 308 ILE n 
1 309 GLU n 
1 310 GLY n 
1 311 ARG n 
1 312 THR n 
1 313 ALA n 
1 314 TYR n 
1 315 LYS n 
1 316 GLY n 
1 317 ALA n 
1 318 LEU n 
1 319 GLN n 
1 320 ASP n 
1 321 THR n 
1 322 ILE n 
1 323 TYR n 
1 324 GLN n 
1 325 LEU n 
1 326 MET n 
1 327 GLY n 
1 328 GLY n 
1 329 VAL n 
1 330 ARG n 
1 331 ALA n 
1 332 GLY n 
1 333 MET n 
1 334 GLY n 
1 335 TYR n 
1 336 THR n 
1 337 GLY n 
1 338 SER n 
1 339 HIS n 
1 340 ASP n 
1 341 LEU n 
1 342 ARG n 
1 343 GLU n 
1 344 LEU n 
1 345 ARG n 
1 346 GLU n 
1 347 GLU n 
1 348 ALA n 
1 349 GLN n 
1 350 PHE n 
1 351 THR n 
1 352 ARG n 
1 353 MET n 
1 354 GLY n 
1 355 PRO n 
1 356 ALA n 
1 357 GLY n 
1 358 LEU n 
1 359 ALA n 
1 360 GLU n 
1 361 SER n 
1 362 HIS n 
1 363 PRO n 
1 364 HIS n 
1 365 ASN n 
1 366 ILE n 
1 367 GLN n 
1 368 ILE n 
1 369 THR n 
1 370 LYS n 
1 371 GLU n 
1 372 SER n 
1 373 PRO n 
1 374 ASN n 
1 375 TYR n 
1 376 SER n 
1 377 PHE n 
1 378 GLY n 
1 379 ASN n 
1 380 SER n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1   108 ? ? 'guaB, SAUSA300_0388' ? ? ? ? ? ? 'Staphylococcus aureus' 1280 ? ? ? ? ? ? ? ? 
'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
1 2 sample 'Biological sequence' 109 380 ? ? 'guaB, SAUSA300_0388' ? ? ? ? ? ? 'Staphylococcus aureus' 1280 ? ? ? ? ? ? ? ? 
'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1AG0 non-polymer         . 
'9-{(1R)-1-[(5P)-5-(4-chloro-1H-imidazol-2-yl)pyridin-3-yl]ethoxy}-1,4-dihydro-2H-pyrano[3,4-c]quinoline' ? 'C22 H19 Cl N4 O2' 
406.865 
ALA   'L-peptide linking' y ALANINE ? 'C3 H7 N O2'       89.093  
ARG   'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'   175.209 
ASN   'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'      132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'       133.103 
CYS   'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'     121.158 
GLN   'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'     146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'       147.129 
GLY   'peptide linking'   y GLYCINE ? 'C2 H5 N O2'       75.067  
HIS   'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'   156.162 
HOH   non-polymer         . WATER ? 'H2 O'             18.015  
ILE   'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'      131.173 
IMP   non-polymer         n 'INOSINIC ACID' ? 'C10 H13 N4 O8 P'  348.206 
LEU   'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'      131.173 
LYS   'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'   147.195 
MET   'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'    149.211 
PHE   'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'      165.189 
PRO   'L-peptide linking' y PROLINE ? 'C5 H9 N O2'       115.130 
SER   'L-peptide linking' y SERINE ? 'C3 H7 N O3'       105.093 
THR   'L-peptide linking' y THREONINE ? 'C4 H9 N O3'       119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'    204.225 
TYR   'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'      181.189 
VAL   'L-peptide linking' y VALINE ? 'C5 H11 N O2'      117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -14 ?   ?   ?   A . n 
A 1 2   HIS 2   -13 ?   ?   ?   A . n 
A 1 3   HIS 3   -12 ?   ?   ?   A . n 
A 1 4   HIS 4   -11 ?   ?   ?   A . n 
A 1 5   HIS 5   -10 ?   ?   ?   A . n 
A 1 6   HIS 6   -9  ?   ?   ?   A . n 
A 1 7   HIS 7   -8  ?   ?   ?   A . n 
A 1 8   GLY 8   -7  ?   ?   ?   A . n 
A 1 9   GLU 9   -6  ?   ?   ?   A . n 
A 1 10  ASN 10  -5  ?   ?   ?   A . n 
A 1 11  LEU 11  -4  ?   ?   ?   A . n 
A 1 12  TYR 12  -3  ?   ?   ?   A . n 
A 1 13  PHE 13  -2  ?   ?   ?   A . n 
A 1 14  GLN 14  -1  ?   ?   ?   A . n 
A 1 15  GLY 15  0   0   GLY GLY A . n 
A 1 16  SER 16  1   1   SER SER A . n 
A 1 17  TRP 17  2   2   TRP TRP A . n 
A 1 18  GLU 18  3   3   GLU GLU A . n 
A 1 19  SER 19  4   4   SER SER A . n 
A 1 20  LYS 20  5   5   LYS LYS A . n 
A 1 21  PHE 21  6   6   PHE PHE A . n 
A 1 22  ALA 22  7   7   ALA ALA A . n 
A 1 23  LYS 23  8   8   LYS LYS A . n 
A 1 24  GLU 24  9   9   GLU GLU A . n 
A 1 25  SER 25  10  10  SER SER A . n 
A 1 26  LEU 26  11  11  LEU LEU A . n 
A 1 27  THR 27  12  12  THR THR A . n 
A 1 28  PHE 28  13  13  PHE PHE A . n 
A 1 29  ASP 29  14  14  ASP ASP A . n 
A 1 30  ASP 30  15  15  ASP ASP A . n 
A 1 31  VAL 31  16  16  VAL VAL A . n 
A 1 32  LEU 32  17  17  LEU LEU A . n 
A 1 33  LEU 33  18  18  LEU LEU A . n 
A 1 34  ILE 34  19  19  ILE ILE A . n 
A 1 35  PRO 35  20  20  PRO PRO A . n 
A 1 36  ALA 36  21  21  ALA ALA A . n 
A 1 37  GLN 37  22  22  GLN GLN A . n 
A 1 38  SER 38  23  23  SER SER A . n 
A 1 39  ASP 39  24  24  ASP ASP A . n 
A 1 40  ILE 40  25  25  ILE ILE A . n 
A 1 41  LEU 41  26  26  LEU LEU A . n 
A 1 42  PRO 42  27  27  PRO PRO A . n 
A 1 43  LYS 43  28  28  LYS LYS A . n 
A 1 44  ASP 44  29  29  ASP ASP A . n 
A 1 45  VAL 45  30  30  VAL VAL A . n 
A 1 46  ASP 46  31  31  ASP ASP A . n 
A 1 47  LEU 47  32  32  LEU LEU A . n 
A 1 48  SER 48  33  33  SER SER A . n 
A 1 49  VAL 49  34  34  VAL VAL A . n 
A 1 50  GLN 50  35  35  GLN GLN A . n 
A 1 51  LEU 51  36  36  LEU LEU A . n 
A 1 52  SER 52  37  37  SER SER A . n 
A 1 53  ASP 53  38  38  ASP ASP A . n 
A 1 54  LYS 54  39  39  LYS LYS A . n 
A 1 55  VAL 55  40  40  VAL VAL A . n 
A 1 56  LYS 56  41  41  LYS LYS A . n 
A 1 57  LEU 57  42  42  LEU LEU A . n 
A 1 58  ASN 58  43  43  ASN ASN A . n 
A 1 59  ILE 59  44  44  ILE ILE A . n 
A 1 60  PRO 60  45  45  PRO PRO A . n 
A 1 61  VAL 61  46  46  VAL VAL A . n 
A 1 62  ILE 62  47  47  ILE ILE A . n 
A 1 63  SER 63  48  48  SER SER A . n 
A 1 64  ALA 64  49  49  ALA ALA A . n 
A 1 65  GLY 65  50  50  GLY GLY A . n 
A 1 66  MET 66  51  51  MET MET A . n 
A 1 67  ASP 67  52  52  ASP ASP A . n 
A 1 68  THR 68  53  53  THR THR A . n 
A 1 69  VAL 69  54  54  VAL VAL A . n 
A 1 70  THR 70  55  55  THR THR A . n 
A 1 71  GLU 71  56  56  GLU GLU A . n 
A 1 72  SER 72  57  57  SER SER A . n 
A 1 73  LYS 73  58  58  LYS LYS A . n 
A 1 74  MET 74  59  59  MET MET A . n 
A 1 75  ALA 75  60  60  ALA ALA A . n 
A 1 76  ILE 76  61  61  ILE ILE A . n 
A 1 77  ALA 77  62  62  ALA ALA A . n 
A 1 78  MET 78  63  63  MET MET A . n 
A 1 79  ALA 79  64  64  ALA ALA A . n 
A 1 80  ARG 80  65  65  ARG ARG A . n 
A 1 81  GLN 81  66  66  GLN GLN A . n 
A 1 82  GLY 82  67  67  GLY GLY A . n 
A 1 83  GLY 83  68  68  GLY GLY A . n 
A 1 84  LEU 84  69  69  LEU LEU A . n 
A 1 85  GLY 85  70  70  GLY GLY A . n 
A 1 86  VAL 86  71  71  VAL VAL A . n 
A 1 87  ILE 87  72  72  ILE ILE A . n 
A 1 88  HIS 88  73  73  HIS HIS A . n 
A 1 89  LYS 89  74  74  LYS LYS A . n 
A 1 90  ASN 90  75  75  ASN ASN A . n 
A 1 91  MET 91  76  76  MET MET A . n 
A 1 92  GLY 92  77  77  GLY GLY A . n 
A 1 93  VAL 93  78  78  VAL VAL A . n 
A 1 94  GLU 94  79  79  GLU GLU A . n 
A 1 95  GLU 95  80  80  GLU GLU A . n 
A 1 96  GLN 96  81  81  GLN GLN A . n 
A 1 97  ALA 97  82  82  ALA ALA A . n 
A 1 98  ASP 98  83  83  ASP ASP A . n 
A 1 99  GLU 99  84  84  GLU GLU A . n 
A 1 100 VAL 100 85  85  VAL VAL A . n 
A 1 101 GLN 101 86  86  GLN GLN A . n 
A 1 102 LYS 102 87  87  LYS LYS A . n 
A 1 103 VAL 103 88  88  VAL VAL A . n 
A 1 104 LYS 104 89  89  LYS LYS A . n 
A 1 105 ARG 105 90  90  ARG ARG A . n 
A 1 106 SER 106 91  91  SER SER A . n 
A 1 107 GLY 107 92  92  GLY GLY A . n 
A 1 108 GLY 108 93  93  GLY GLY A . n 
A 1 109 LEU 109 220 220 LEU LEU A . n 
A 1 110 LEU 110 221 221 LEU LEU A . n 
A 1 111 VAL 111 222 222 VAL VAL A . n 
A 1 112 ALA 112 223 223 ALA ALA A . n 
A 1 113 ALA 113 224 224 ALA ALA A . n 
A 1 114 ALA 114 225 225 ALA ALA A . n 
A 1 115 ILE 115 226 226 ILE ILE A . n 
A 1 116 GLY 116 227 227 GLY GLY A . n 
A 1 117 ILE 117 228 228 ILE ILE A . n 
A 1 118 SER 118 229 229 SER SER A . n 
A 1 119 LYS 119 230 230 LYS LYS A . n 
A 1 120 ASP 120 231 231 ASP ASP A . n 
A 1 121 THR 121 232 232 THR THR A . n 
A 1 122 ASP 122 233 233 ASP ASP A . n 
A 1 123 ILE 123 234 234 ILE ILE A . n 
A 1 124 ARG 124 235 235 ARG ARG A . n 
A 1 125 ALA 125 236 236 ALA ALA A . n 
A 1 126 GLN 126 237 237 GLN GLN A . n 
A 1 127 LYS 127 238 238 LYS LYS A . n 
A 1 128 LEU 128 239 239 LEU LEU A . n 
A 1 129 VAL 129 240 240 VAL VAL A . n 
A 1 130 GLU 130 241 241 GLU GLU A . n 
A 1 131 ALA 131 242 242 ALA ALA A . n 
A 1 132 GLY 132 243 243 GLY GLY A . n 
A 1 133 VAL 133 244 244 VAL VAL A . n 
A 1 134 ASP 134 245 245 ASP ASP A . n 
A 1 135 VAL 135 246 246 VAL VAL A . n 
A 1 136 LEU 136 247 247 LEU LEU A . n 
A 1 137 VAL 137 248 248 VAL VAL A . n 
A 1 138 ILE 138 249 249 ILE ILE A . n 
A 1 139 ASP 139 250 250 ASP ASP A . n 
A 1 140 THR 140 251 251 THR THR A . n 
A 1 141 ALA 141 252 252 ALA ALA A . n 
A 1 142 HIS 142 253 253 HIS HIS A . n 
A 1 143 GLY 143 254 254 GLY GLY A . n 
A 1 144 HIS 144 255 255 HIS HIS A . n 
A 1 145 SER 145 256 256 SER SER A . n 
A 1 146 LYS 146 257 257 LYS LYS A . n 
A 1 147 GLY 147 258 258 GLY GLY A . n 
A 1 148 VAL 148 259 259 VAL VAL A . n 
A 1 149 ILE 149 260 260 ILE ILE A . n 
A 1 150 ASP 150 261 261 ASP ASP A . n 
A 1 151 GLN 151 262 262 GLN GLN A . n 
A 1 152 VAL 152 263 263 VAL VAL A . n 
A 1 153 LYS 153 264 264 LYS LYS A . n 
A 1 154 HIS 154 265 265 HIS HIS A . n 
A 1 155 ILE 155 266 266 ILE ILE A . n 
A 1 156 LYS 156 267 267 LYS LYS A . n 
A 1 157 LYS 157 268 268 LYS LYS A . n 
A 1 158 THR 158 269 269 THR THR A . n 
A 1 159 TYR 159 270 270 TYR TYR A . n 
A 1 160 PRO 160 271 271 PRO PRO A . n 
A 1 161 GLU 161 272 272 GLU GLU A . n 
A 1 162 ILE 162 273 273 ILE ILE A . n 
A 1 163 THR 163 274 274 THR THR A . n 
A 1 164 LEU 164 275 275 LEU LEU A . n 
A 1 165 VAL 165 276 276 VAL VAL A . n 
A 1 166 ALA 166 277 277 ALA ALA A . n 
A 1 167 GLY 167 278 278 GLY GLY A . n 
A 1 168 ASN 168 279 279 ASN ASN A . n 
A 1 169 VAL 169 280 280 VAL VAL A . n 
A 1 170 ALA 170 281 281 ALA ALA A . n 
A 1 171 THR 171 282 282 THR THR A . n 
A 1 172 ALA 172 283 283 ALA ALA A . n 
A 1 173 GLU 173 284 284 GLU GLU A . n 
A 1 174 ALA 174 285 285 ALA ALA A . n 
A 1 175 THR 175 286 286 THR THR A . n 
A 1 176 LYS 176 287 287 LYS LYS A . n 
A 1 177 ASP 177 288 288 ASP ASP A . n 
A 1 178 LEU 178 289 289 LEU LEU A . n 
A 1 179 PHE 179 290 290 PHE PHE A . n 
A 1 180 GLU 180 291 291 GLU GLU A . n 
A 1 181 ALA 181 292 292 ALA ALA A . n 
A 1 182 GLY 182 293 293 GLY GLY A . n 
A 1 183 ALA 183 294 294 ALA ALA A . n 
A 1 184 ASP 184 295 295 ASP ASP A . n 
A 1 185 ILE 185 296 296 ILE ILE A . n 
A 1 186 VAL 186 297 297 VAL VAL A . n 
A 1 187 LYS 187 298 298 LYS LYS A . n 
A 1 188 VAL 188 299 299 VAL VAL A . n 
A 1 189 GLY 189 300 300 GLY GLY A . n 
A 1 190 ILE 190 301 301 ILE ILE A . n 
A 1 191 GLY 191 302 302 GLY GLY A . n 
A 1 192 PRO 192 303 303 PRO PRO A . n 
A 1 193 GLY 193 304 304 GLY GLY A . n 
A 1 194 SER 194 305 305 SER SER A . n 
A 1 195 ILE 195 306 306 ILE ILE A . n 
A 1 196 CYS 196 307 307 CYS CYS A . n 
A 1 197 THR 197 308 308 THR THR A . n 
A 1 198 THR 198 309 309 THR THR A . n 
A 1 199 ARG 199 310 310 ARG ARG A . n 
A 1 200 VAL 200 311 311 VAL VAL A . n 
A 1 201 VAL 201 312 312 VAL VAL A . n 
A 1 202 ALA 202 313 313 ALA ALA A . n 
A 1 203 GLY 203 314 314 GLY GLY A . n 
A 1 204 VAL 204 315 315 VAL VAL A . n 
A 1 205 GLY 205 316 316 GLY GLY A . n 
A 1 206 VAL 206 317 317 VAL VAL A . n 
A 1 207 PRO 207 318 318 PRO PRO A . n 
A 1 208 GLN 208 319 319 GLN GLN A . n 
A 1 209 ILE 209 320 320 ILE ILE A . n 
A 1 210 THR 210 321 321 THR THR A . n 
A 1 211 ALA 211 322 322 ALA ALA A . n 
A 1 212 ILE 212 323 323 ILE ILE A . n 
A 1 213 TYR 213 324 324 TYR TYR A . n 
A 1 214 ASP 214 325 325 ASP ASP A . n 
A 1 215 CYS 215 326 326 CYS CYS A . n 
A 1 216 ALA 216 327 327 ALA ALA A . n 
A 1 217 THR 217 328 328 THR THR A . n 
A 1 218 GLU 218 329 329 GLU GLU A . n 
A 1 219 ALA 219 330 330 ALA ALA A . n 
A 1 220 ARG 220 331 331 ARG ARG A . n 
A 1 221 LYS 221 332 332 LYS LYS A . n 
A 1 222 HIS 222 333 333 HIS HIS A . n 
A 1 223 GLY 223 334 334 GLY GLY A . n 
A 1 224 LYS 224 335 335 LYS LYS A . n 
A 1 225 ALA 225 336 336 ALA ALA A . n 
A 1 226 ILE 226 337 337 ILE ILE A . n 
A 1 227 ILE 227 338 338 ILE ILE A . n 
A 1 228 ALA 228 339 339 ALA ALA A . n 
A 1 229 ASP 229 340 340 ASP ASP A . n 
A 1 230 GLY 230 341 341 GLY GLY A . n 
A 1 231 GLY 231 342 342 GLY GLY A . n 
A 1 232 ILE 232 343 343 ILE ILE A . n 
A 1 233 LYS 233 344 344 LYS LYS A . n 
A 1 234 PHE 234 345 345 PHE PHE A . n 
A 1 235 SER 235 346 346 SER SER A . n 
A 1 236 GLY 236 347 347 GLY GLY A . n 
A 1 237 ASP 237 348 348 ASP ASP A . n 
A 1 238 ILE 238 349 349 ILE ILE A . n 
A 1 239 ILE 239 350 350 ILE ILE A . n 
A 1 240 LYS 240 351 351 LYS LYS A . n 
A 1 241 ALA 241 352 352 ALA ALA A . n 
A 1 242 LEU 242 353 353 LEU LEU A . n 
A 1 243 ALA 243 354 354 ALA ALA A . n 
A 1 244 ALA 244 355 355 ALA ALA A . n 
A 1 245 GLY 245 356 356 GLY GLY A . n 
A 1 246 GLY 246 357 357 GLY GLY A . n 
A 1 247 HIS 247 358 358 HIS HIS A . n 
A 1 248 ALA 248 359 359 ALA ALA A . n 
A 1 249 VAL 249 360 360 VAL VAL A . n 
A 1 250 MET 250 361 361 MET MET A . n 
A 1 251 LEU 251 362 362 LEU LEU A . n 
A 1 252 GLY 252 363 363 GLY GLY A . n 
A 1 253 SER 253 364 364 SER SER A . n 
A 1 254 LEU 254 365 365 LEU LEU A . n 
A 1 255 LEU 255 366 366 LEU LEU A . n 
A 1 256 ALA 256 367 367 ALA ALA A . n 
A 1 257 GLY 257 368 368 GLY GLY A . n 
A 1 258 THR 258 369 369 THR THR A . n 
A 1 259 GLU 259 370 370 GLU GLU A . n 
A 1 260 GLU 260 371 371 GLU GLU A . n 
A 1 261 SER 261 372 372 SER SER A . n 
A 1 262 PRO 262 373 373 PRO PRO A . n 
A 1 263 GLY 263 374 374 GLY GLY A . n 
A 1 264 ALA 264 375 375 ALA ALA A . n 
A 1 265 THR 265 376 376 THR THR A . n 
A 1 266 GLU 266 377 377 GLU GLU A . n 
A 1 267 ILE 267 378 378 ILE ILE A . n 
A 1 268 PHE 268 379 379 PHE PHE A . n 
A 1 269 GLN 269 380 380 GLN GLN A . n 
A 1 270 GLY 270 381 381 GLY GLY A . n 
A 1 271 ARG 271 382 382 ARG ARG A . n 
A 1 272 GLN 272 383 383 GLN GLN A . n 
A 1 273 TYR 273 384 384 TYR TYR A . n 
A 1 274 LYS 274 385 385 LYS LYS A . n 
A 1 275 VAL 275 386 386 VAL VAL A . n 
A 1 276 TYR 276 387 387 TYR TYR A . n 
A 1 277 ARG 277 388 388 ARG ARG A . n 
A 1 278 GLY 278 389 389 GLY GLY A . n 
A 1 279 MET 279 390 390 MET MET A . n 
A 1 280 GLY 280 391 391 GLY GLY A . n 
A 1 281 SER 281 392 392 SER SER A . n 
A 1 282 LEU 282 393 393 LEU LEU A . n 
A 1 283 GLY 283 394 394 GLY GLY A . n 
A 1 284 ALA 284 395 395 ALA ALA A . n 
A 1 285 MET 285 396 396 MET MET A . n 
A 1 286 GLU 286 397 397 GLU GLU A . n 
A 1 287 LYS 287 398 ?   ?   ?   A . n 
A 1 288 GLY 288 399 ?   ?   ?   A . n 
A 1 289 SER 289 400 ?   ?   ?   A . n 
A 1 290 ASN 290 401 ?   ?   ?   A . n 
A 1 291 ASP 291 402 ?   ?   ?   A . n 
A 1 292 ARG 292 403 ?   ?   ?   A . n 
A 1 293 TYR 293 404 ?   ?   ?   A . n 
A 1 294 PHE 294 405 ?   ?   ?   A . n 
A 1 295 GLN 295 406 ?   ?   ?   A . n 
A 1 296 GLU 296 407 ?   ?   ?   A . n 
A 1 297 ASP 297 408 ?   ?   ?   A . n 
A 1 298 LYS 298 409 ?   ?   ?   A . n 
A 1 299 ALA 299 410 ?   ?   ?   A . n 
A 1 300 PRO 300 411 ?   ?   ?   A . n 
A 1 301 LYS 301 412 ?   ?   ?   A . n 
A 1 302 LYS 302 413 413 LYS ALA A . n 
A 1 303 PHE 303 414 414 PHE PHE A . n 
A 1 304 VAL 304 415 415 VAL VAL A . n 
A 1 305 PRO 305 416 416 PRO PRO A . n 
A 1 306 GLU 306 417 417 GLU GLU A . n 
A 1 307 GLY 307 418 418 GLY GLY A . n 
A 1 308 ILE 308 419 419 ILE ILE A . n 
A 1 309 GLU 309 420 420 GLU GLU A . n 
A 1 310 GLY 310 421 421 GLY GLY A . n 
A 1 311 ARG 311 422 422 ARG ARG A . n 
A 1 312 THR 312 423 423 THR THR A . n 
A 1 313 ALA 313 424 424 ALA ALA A . n 
A 1 314 TYR 314 425 425 TYR TYR A . n 
A 1 315 LYS 315 426 426 LYS LYS A . n 
A 1 316 GLY 316 427 427 GLY GLY A . n 
A 1 317 ALA 317 428 428 ALA ALA A . n 
A 1 318 LEU 318 429 429 LEU LEU A . n 
A 1 319 GLN 319 430 430 GLN GLN A . n 
A 1 320 ASP 320 431 431 ASP ASP A . n 
A 1 321 THR 321 432 432 THR THR A . n 
A 1 322 ILE 322 433 433 ILE ILE A . n 
A 1 323 TYR 323 434 434 TYR TYR A . n 
A 1 324 GLN 324 435 435 GLN GLN A . n 
A 1 325 LEU 325 436 436 LEU LEU A . n 
A 1 326 MET 326 437 437 MET MET A . n 
A 1 327 GLY 327 438 438 GLY GLY A . n 
A 1 328 GLY 328 439 439 GLY GLY A . n 
A 1 329 VAL 329 440 440 VAL VAL A . n 
A 1 330 ARG 330 441 441 ARG ARG A . n 
A 1 331 ALA 331 442 442 ALA ALA A . n 
A 1 332 GLY 332 443 443 GLY GLY A . n 
A 1 333 MET 333 444 444 MET MET A . n 
A 1 334 GLY 334 445 445 GLY GLY A . n 
A 1 335 TYR 335 446 446 TYR TYR A . n 
A 1 336 THR 336 447 447 THR THR A . n 
A 1 337 GLY 337 448 448 GLY GLY A . n 
A 1 338 SER 338 449 449 SER SER A . n 
A 1 339 HIS 339 450 450 HIS HIS A . n 
A 1 340 ASP 340 451 451 ASP ASP A . n 
A 1 341 LEU 341 452 452 LEU LEU A . n 
A 1 342 ARG 342 453 453 ARG ARG A . n 
A 1 343 GLU 343 454 454 GLU GLU A . n 
A 1 344 LEU 344 455 455 LEU LEU A . n 
A 1 345 ARG 345 456 456 ARG ARG A . n 
A 1 346 GLU 346 457 457 GLU GLU A . n 
A 1 347 GLU 347 458 458 GLU GLU A . n 
A 1 348 ALA 348 459 459 ALA ALA A . n 
A 1 349 GLN 349 460 460 GLN GLN A . n 
A 1 350 PHE 350 461 461 PHE PHE A . n 
A 1 351 THR 351 462 462 THR THR A . n 
A 1 352 ARG 352 463 463 ARG ARG A . n 
A 1 353 MET 353 464 464 MET MET A . n 
A 1 354 GLY 354 465 465 GLY GLY A . n 
A 1 355 PRO 355 466 466 PRO PRO A . n 
A 1 356 ALA 356 467 ?   ?   ?   A . n 
A 1 357 GLY 357 468 ?   ?   ?   A . n 
A 1 358 LEU 358 469 ?   ?   ?   A . n 
A 1 359 ALA 359 470 ?   ?   ?   A . n 
A 1 360 GLU 360 471 ?   ?   ?   A . n 
A 1 361 SER 361 472 ?   ?   ?   A . n 
A 1 362 HIS 362 473 ?   ?   ?   A . n 
A 1 363 PRO 363 474 ?   ?   ?   A . n 
A 1 364 HIS 364 475 ?   ?   ?   A . n 
A 1 365 ASN 365 476 ?   ?   ?   A . n 
A 1 366 ILE 366 477 ?   ?   ?   A . n 
A 1 367 GLN 367 478 ?   ?   ?   A . n 
A 1 368 ILE 368 479 ?   ?   ?   A . n 
A 1 369 THR 369 480 ?   ?   ?   A . n 
A 1 370 LYS 370 481 ?   ?   ?   A . n 
A 1 371 GLU 371 482 ?   ?   ?   A . n 
A 1 372 SER 372 483 ?   ?   ?   A . n 
A 1 373 PRO 373 484 ?   ?   ?   A . n 
A 1 374 ASN 374 485 ?   ?   ?   A . n 
A 1 375 TYR 375 486 ?   ?   ?   A . n 
A 1 376 SER 376 487 ?   ?   ?   A . n 
A 1 377 PHE 377 488 ?   ?   ?   A . n 
A 1 378 GLY 378 489 ?   ?   ?   A . n 
A 1 379 ASN 379 490 ?   ?   ?   A . n 
A 1 380 SER 380 491 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1AG0 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1AG0 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 IMP   1  801 801 IMP   IMP A . 
C 3 A1AG0 1  802 1   A1AG0 DRG A . 
D 4 HOH   1  901 30  HOH   HOH A . 
D 4 HOH   2  902 26  HOH   HOH A . 
D 4 HOH   3  903 23  HOH   HOH A . 
D 4 HOH   4  904 3   HOH   HOH A . 
D 4 HOH   5  905 14  HOH   HOH A . 
D 4 HOH   6  906 1   HOH   HOH A . 
D 4 HOH   7  907 28  HOH   HOH A . 
D 4 HOH   8  908 6   HOH   HOH A . 
D 4 HOH   9  909 15  HOH   HOH A . 
D 4 HOH   10 910 18  HOH   HOH A . 
D 4 HOH   11 911 19  HOH   HOH A . 
D 4 HOH   12 912 9   HOH   HOH A . 
D 4 HOH   13 913 4   HOH   HOH A . 
D 4 HOH   14 914 10  HOH   HOH A . 
D 4 HOH   15 915 2   HOH   HOH A . 
D 4 HOH   16 916 25  HOH   HOH A . 
D 4 HOH   17 917 27  HOH   HOH A . 
D 4 HOH   18 918 8   HOH   HOH A . 
D 4 HOH   19 919 12  HOH   HOH A . 
D 4 HOH   20 920 20  HOH   HOH A . 
D 4 HOH   21 921 17  HOH   HOH A . 
D 4 HOH   22 922 16  HOH   HOH A . 
D 4 HOH   23 923 24  HOH   HOH A . 
D 4 HOH   24 924 21  HOH   HOH A . 
D 4 HOH   25 925 13  HOH   HOH A . 
D 4 HOH   26 926 5   HOH   HOH A . 
D 4 HOH   27 927 11  HOH   HOH A . 
D 4 HOH   28 928 22  HOH   HOH A . 
D 4 HOH   29 929 29  HOH   HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A LYS 413 ? CG ? A LYS 302 CG 
2 1 Y 1 A LYS 413 ? CD ? A LYS 302 CD 
3 1 Y 1 A LYS 413 ? CE ? A LYS 302 CE 
4 1 Y 1 A LYS 413 ? NZ ? A LYS 302 NZ 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? BUSTER  ? ? ? 2.11.6 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .      2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .      3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .      4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9AV0 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     104.442 
_cell.length_a_esd                 ? 
_cell.length_b                     104.442 
_cell.length_b_esd                 ? 
_cell.length_c                     64.413 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9AV0 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                79 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'I 4' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9AV0 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.16 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          43.14 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              9 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1M Bicine pH 9, 0.1M NaCl, 30% PEG550 MME' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2019-02-28 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9792 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'APS BEAMLINE 24-ID-C' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9792 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   24-ID-C 
_diffrn_source.pdbx_synchrotron_site       APS 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9AV0 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.20 
_reflns.d_resolution_low                               73.85 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     17517 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.4 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.6 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          16.6 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.060 
_reflns.pdbx_Rpim_I_all                                0.023 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       115512 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.055 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.20 
_reflns_shell.d_res_low                                     2.32 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           15795 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2351 
_reflns_shell.percent_possible_obs                          90.7 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               6.7 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     1.9 
_reflns_shell.pdbx_Rrim_I_all                               0.934 
_reflns_shell.pdbx_Rpim_I_all                               0.357 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.719 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.862 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            6.05110 
_refine.aniso_B[1][2]                            0.00000 
_refine.aniso_B[1][3]                            0.00000 
_refine.aniso_B[2][2]                            6.05110 
_refine.aniso_B[2][3]                            0.00000 
_refine.aniso_B[3][3]                            -12.10210 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               76.29 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.938 
_refine.correlation_coeff_Fo_to_Fc_free          0.928 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9AV0 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.20 
_refine.ls_d_res_low                             73.85 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     17437 
_refine.ls_number_reflns_R_free                  905 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.3 
_refine.ls_percent_reflns_R_free                 5.190 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.226 
_refine.ls_R_factor_R_free                       0.251 
_refine.ls_R_factor_R_free_error                 0.000 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.225 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          0.000 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   0.214 
_refine.pdbx_overall_SU_R_free_Blow_DPI          0.207 
_refine.pdbx_overall_SU_R_Blow_DPI               0.287 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             0.302 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_analyze.entry_id                        9AV0 
_refine_analyze.pdbx_refine_id                  'X-RAY DIFFRACTION' 
_refine_analyze.Luzzati_coordinate_error_free   ? 
_refine_analyze.Luzzati_coordinate_error_obs    0.41 
_refine_analyze.Luzzati_d_res_low_free          ? 
_refine_analyze.Luzzati_d_res_low_obs           ? 
_refine_analyze.Luzzati_sigma_a_free            ? 
_refine_analyze.Luzzati_sigma_a_free_details    ? 
_refine_analyze.Luzzati_sigma_a_obs             ? 
_refine_analyze.Luzzati_sigma_a_obs_details     ? 
_refine_analyze.number_disordered_residues      ? 
_refine_analyze.occupancy_sum_hydrogen          ? 
_refine_analyze.occupancy_sum_non_hydrogen      ? 
_refine_analyze.RG_d_res_high                   ? 
_refine_analyze.RG_d_res_low                    ? 
_refine_analyze.RG_free                         ? 
_refine_analyze.RG_work                         ? 
_refine_analyze.RG_free_work_ratio              ? 
_refine_analyze.pdbx_Luzzati_d_res_high_obs     ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.20 
_refine_hist.d_res_low                        73.85 
_refine_hist.number_atoms_solvent             29 
_refine_hist.number_atoms_total               2480 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2399 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         52 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.008 ? 2632 ? t_bond_d                  2.00  HARMONIC     
'X-RAY DIFFRACTION' ? 1.08  ? 3588 ? t_angle_deg               2.00  HARMONIC     
'X-RAY DIFFRACTION' ? ?     ? 936  ? t_dihedral_angle_d        2.00  SINUSOIDAL   
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_incorr_chiral_ct        ?     ?            
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_pseud_angle             ?     ?            
'X-RAY DIFFRACTION' ? ?     ? 62   ? t_trig_c_planes           2.00  HARMONIC     
'X-RAY DIFFRACTION' ? ?     ? 411  ? t_gen_planes              5.00  HARMONIC     
'X-RAY DIFFRACTION' ? ?     ? 2632 ? t_it                      20.00 HARMONIC     
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_nbd                     ?     ?            
'X-RAY DIFFRACTION' ? 2.30  ? ?    ? t_omega_torsion           ?     ?            
'X-RAY DIFFRACTION' ? 19.71 ? ?    ? t_other_torsion           ?     ?            
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_improper_torsion        ?     ?            
'X-RAY DIFFRACTION' ? ?     ? 349  ? t_chiral_improper_torsion 5.00  SEMIHARMONIC 
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_sum_occupancies         ?     ?            
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_utility_distance        ?     ?            
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_utility_angle           ?     ?            
'X-RAY DIFFRACTION' ? ?     ? ?    ? t_utility_torsion         ?     ?            
'X-RAY DIFFRACTION' ? ?     ? 3111 ? t_ideal_dist_contact      4.00  SEMIHARMONIC 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       2.20 
_refine_ls_shell.d_res_low                        2.33 
_refine_ls_shell.number_reflns_all                2607 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             128 
_refine_ls_shell.number_reflns_R_work             2479 
_refine_ls_shell.percent_reflns_obs               91.52 
_refine_ls_shell.percent_reflns_R_free            4.91 
_refine_ls_shell.R_factor_all                     0.252 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            0.000 
_refine_ls_shell.R_factor_R_work                  0.251 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   9 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.280 
# 
_struct.entry_id                     9AV0 
_struct.title                        'Crystal structure of S. aureus GuaB dCBS with inhibitor GNE2011' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9AV0 
_struct_keywords.text            'GuaB, inhibitor, OXIDOREDUCTASE' 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP IMDH_STAA3 Q2FJM6 ? 1 
;WESKFAKESLTFDDVLLIPAQSDILPKDVDLSVQLSDKVKLNIPVISAGMDTVTESKMAIAMARQGGLGVIHKNMGVEEQ
ADEVQKVKRS
;
2   
2 UNP IMDH_STAA3 Q2FJM6 ? 1 
;LLVAAAIGISKDTDIRAQKLVEAGVDVLVIDTAHGHSKGVIDQVKHIKKTYPEITLVAGNVATAEATKDLFEAGADIVKV
GIGPGSICTTRVVAGVGVPQITAIYDCATEARKHGKAIIADGGIKFSGDIIKALAAGGHAVMLGSLLAGTEESPGATEIF
QGRQYKVYRGMGSLGAMEKGSNDRYFQEDKAPKKFVPEGIEGRTAYKGALQDTIYQLMGGVRAGMGYTGSHDLRELREEA
QFTRMGPAGLAESHPHNIQITKESPNYSF
;
220 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9AV0 A 17  ? 106 ? Q2FJM6 2   ? 91  ? 2   91  
2 2 9AV0 A 109 ? 377 ? Q2FJM6 220 ? 488 ? 220 488 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9AV0 MET A 1   ? UNP Q2FJM6 ? ? 'initiating methionine' -14 1  
1 9AV0 HIS A 2   ? UNP Q2FJM6 ? ? 'expression tag'        -13 2  
1 9AV0 HIS A 3   ? UNP Q2FJM6 ? ? 'expression tag'        -12 3  
1 9AV0 HIS A 4   ? UNP Q2FJM6 ? ? 'expression tag'        -11 4  
1 9AV0 HIS A 5   ? UNP Q2FJM6 ? ? 'expression tag'        -10 5  
1 9AV0 HIS A 6   ? UNP Q2FJM6 ? ? 'expression tag'        -9  6  
1 9AV0 HIS A 7   ? UNP Q2FJM6 ? ? 'expression tag'        -8  7  
1 9AV0 GLY A 8   ? UNP Q2FJM6 ? ? 'expression tag'        -7  8  
1 9AV0 GLU A 9   ? UNP Q2FJM6 ? ? 'expression tag'        -6  9  
1 9AV0 ASN A 10  ? UNP Q2FJM6 ? ? 'expression tag'        -5  10 
1 9AV0 LEU A 11  ? UNP Q2FJM6 ? ? 'expression tag'        -4  11 
1 9AV0 TYR A 12  ? UNP Q2FJM6 ? ? 'expression tag'        -3  12 
1 9AV0 PHE A 13  ? UNP Q2FJM6 ? ? 'expression tag'        -2  13 
1 9AV0 GLN A 14  ? UNP Q2FJM6 ? ? 'expression tag'        -1  14 
1 9AV0 GLY A 15  ? UNP Q2FJM6 ? ? 'expression tag'        0   15 
1 9AV0 SER A 16  ? UNP Q2FJM6 ? ? 'expression tag'        1   16 
1 9AV0 GLY A 107 ? UNP Q2FJM6 ? ? linker                  92  17 
1 9AV0 GLY A 108 ? UNP Q2FJM6 ? ? linker                  93  18 
2 9AV0 GLY A 378 ? UNP Q2FJM6 ? ? 'expression tag'        489 19 
2 9AV0 ASN A 379 ? UNP Q2FJM6 ? ? 'expression tag'        490 20 
2 9AV0 SER A 380 ? UNP Q2FJM6 ? ? 'expression tag'        491 21 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   tetrameric 
_pdbx_struct_assembly.oligomeric_count     4 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 16290 ? 
1 MORE         -88   ? 
1 'SSA (A^2)'  46950 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2,3,4 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z       1.0000000000  0.0000000000  0.0000000000 0.0000000000   0.0000000000  
1.0000000000  0.0000000000 0.0000000000   0.0000000000 0.0000000000 1.0000000000 0.0000000000 
2 'crystal symmetry operation' 2_775 -x+2,-y+2,z -1.0000000000 0.0000000000  0.0000000000 208.8840000000 0.0000000000  
-1.0000000000 0.0000000000 208.8840000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 
3 'crystal symmetry operation' 3_755 -y+2,x,z    0.0000000000  -1.0000000000 0.0000000000 208.8840000000 1.0000000000  
0.0000000000  0.0000000000 0.0000000000   0.0000000000 0.0000000000 1.0000000000 0.0000000000 
4 'crystal symmetry operation' 4_575 y,-x+2,z    0.0000000000  1.0000000000  0.0000000000 0.0000000000   -1.0000000000 
0.0000000000  0.0000000000 208.8840000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 27  ? ASP A 29  ? THR A 12  ASP A 14  5 ? 3  
HELX_P HELX_P2  AA2 LEU A 41  ? VAL A 45  ? LEU A 26  VAL A 30  5 ? 5  
HELX_P HELX_P3  AA3 GLU A 71  ? GLN A 81  ? GLU A 56  GLN A 66  1 ? 11 
HELX_P HELX_P4  AA4 GLY A 92  ? ARG A 105 ? GLY A 77  ARG A 90  1 ? 14 
HELX_P HELX_P5  AA5 ASP A 120 ? GLY A 132 ? ASP A 231 GLY A 243 1 ? 13 
HELX_P HELX_P6  AA6 SER A 145 ? TYR A 159 ? SER A 256 TYR A 270 1 ? 15 
HELX_P HELX_P7  AA7 THR A 171 ? GLY A 182 ? THR A 282 GLY A 293 1 ? 12 
HELX_P HELX_P8  AA8 THR A 197 ? GLY A 203 ? THR A 308 GLY A 314 1 ? 7  
HELX_P HELX_P9  AA9 PRO A 207 ? ARG A 220 ? PRO A 318 ARG A 331 1 ? 14 
HELX_P HELX_P10 AB1 PHE A 234 ? ALA A 244 ? PHE A 345 ALA A 355 1 ? 11 
HELX_P HELX_P11 AB2 GLY A 252 ? ALA A 256 ? GLY A 363 ALA A 367 5 ? 5  
HELX_P HELX_P12 AB3 SER A 281 ? GLU A 286 ? SER A 392 GLU A 397 1 ? 6  
HELX_P HELX_P13 AB4 ALA A 317 ? GLY A 337 ? ALA A 428 GLY A 448 1 ? 21 
HELX_P HELX_P14 AB5 ASP A 340 ? ALA A 348 ? ASP A 451 ALA A 459 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          GLY 
_struct_mon_prot_cis.label_seq_id           167 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           GLY 
_struct_mon_prot_cis.auth_seq_id            278 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   ASN 
_struct_mon_prot_cis.pdbx_label_seq_id_2    168 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    ASN 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     279 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       0.29 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 2 ? 
AA3 ? 9 ? 
AA4 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? parallel      
AA3 3 4 ? parallel      
AA3 4 5 ? parallel      
AA3 5 6 ? parallel      
AA3 6 7 ? parallel      
AA3 7 8 ? parallel      
AA3 8 9 ? parallel      
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 31  ? LEU A 33  ? VAL A 16  LEU A 18  
AA1 2 PHE A 350 ? ARG A 352 ? PHE A 461 ARG A 463 
AA2 1 VAL A 49  ? GLN A 50  ? VAL A 34  GLN A 35  
AA2 2 LYS A 56  ? LEU A 57  ? LYS A 41  LEU A 42  
AA3 1 VAL A 61  ? SER A 63  ? VAL A 46  SER A 48  
AA3 2 LEU A 84  ? ILE A 87  ? LEU A 69  ILE A 72  
AA3 3 ALA A 112 ? ILE A 115 ? ALA A 223 ILE A 226 
AA3 4 VAL A 135 ? ASP A 139 ? VAL A 246 ASP A 250 
AA3 5 THR A 163 ? VAL A 169 ? THR A 274 VAL A 280 
AA3 6 ILE A 185 ? VAL A 188 ? ILE A 296 VAL A 299 
AA3 7 ALA A 225 ? ASP A 229 ? ALA A 336 ASP A 340 
AA3 8 ALA A 248 ? LEU A 251 ? ALA A 359 LEU A 362 
AA3 9 VAL A 61  ? SER A 63  ? VAL A 46  SER A 48  
AA4 1 GLU A 266 ? PHE A 268 ? GLU A 377 PHE A 379 
AA4 2 ARG A 271 ? ARG A 277 ? ARG A 382 ARG A 388 
AA4 3 GLU A 309 ? ALA A 313 ? GLU A 420 ALA A 424 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N LEU A 32  ? N LEU A 17  O THR A 351 ? O THR A 462 
AA2 1 2 N VAL A 49  ? N VAL A 34  O LEU A 57  ? O LEU A 42  
AA3 1 2 N SER A 63  ? N SER A 48  O LEU A 84  ? O LEU A 69  
AA3 2 3 N ILE A 87  ? N ILE A 72  O ALA A 112 ? O ALA A 223 
AA3 3 4 N ALA A 113 ? N ALA A 224 O VAL A 137 ? O VAL A 248 
AA3 4 5 N ILE A 138 ? N ILE A 249 O VAL A 165 ? O VAL A 276 
AA3 5 6 N ALA A 166 ? N ALA A 277 O LYS A 187 ? O LYS A 298 
AA3 6 7 N VAL A 188 ? N VAL A 299 O ILE A 227 ? O ILE A 338 
AA3 7 8 N ALA A 228 ? N ALA A 339 O ALA A 248 ? O ALA A 359 
AA3 8 9 O VAL A 249 ? O VAL A 360 N ILE A 62  ? N ILE A 47  
AA4 1 2 N GLU A 266 ? N GLU A 377 O TYR A 273 ? O TYR A 384 
AA4 2 3 N LYS A 274 ? N LYS A 385 O THR A 312 ? O THR A 423 
# 
_pdbx_entry_details.entry_id                   9AV0 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 PRO A 45  ? ? -82.65  47.48  
2 1 VAL A 54  ? ? -128.10 -61.93 
3 1 HIS A 255 ? ? -87.05  35.29  
4 1 HIS A 255 ? ? -87.05  33.79  
5 1 ALA A 281 ? ? -148.02 11.43  
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET -14 ? A MET 1   
2  1 Y 1 A HIS -13 ? A HIS 2   
3  1 Y 1 A HIS -12 ? A HIS 3   
4  1 Y 1 A HIS -11 ? A HIS 4   
5  1 Y 1 A HIS -10 ? A HIS 5   
6  1 Y 1 A HIS -9  ? A HIS 6   
7  1 Y 1 A HIS -8  ? A HIS 7   
8  1 Y 1 A GLY -7  ? A GLY 8   
9  1 Y 1 A GLU -6  ? A GLU 9   
10 1 Y 1 A ASN -5  ? A ASN 10  
11 1 Y 1 A LEU -4  ? A LEU 11  
12 1 Y 1 A TYR -3  ? A TYR 12  
13 1 Y 1 A PHE -2  ? A PHE 13  
14 1 Y 1 A GLN -1  ? A GLN 14  
15 1 Y 1 A LYS 398 ? A LYS 287 
16 1 Y 1 A GLY 399 ? A GLY 288 
17 1 Y 1 A SER 400 ? A SER 289 
18 1 Y 1 A ASN 401 ? A ASN 290 
19 1 Y 1 A ASP 402 ? A ASP 291 
20 1 Y 1 A ARG 403 ? A ARG 292 
21 1 Y 1 A TYR 404 ? A TYR 293 
22 1 Y 1 A PHE 405 ? A PHE 294 
23 1 Y 1 A GLN 406 ? A GLN 295 
24 1 Y 1 A GLU 407 ? A GLU 296 
25 1 Y 1 A ASP 408 ? A ASP 297 
26 1 Y 1 A LYS 409 ? A LYS 298 
27 1 Y 1 A ALA 410 ? A ALA 299 
28 1 Y 1 A PRO 411 ? A PRO 300 
29 1 Y 1 A LYS 412 ? A LYS 301 
30 1 Y 1 A ALA 467 ? A ALA 356 
31 1 Y 1 A GLY 468 ? A GLY 357 
32 1 Y 1 A LEU 469 ? A LEU 358 
33 1 Y 1 A ALA 470 ? A ALA 359 
34 1 Y 1 A GLU 471 ? A GLU 360 
35 1 Y 1 A SER 472 ? A SER 361 
36 1 Y 1 A HIS 473 ? A HIS 362 
37 1 Y 1 A PRO 474 ? A PRO 363 
38 1 Y 1 A HIS 475 ? A HIS 364 
39 1 Y 1 A ASN 476 ? A ASN 365 
40 1 Y 1 A ILE 477 ? A ILE 366 
41 1 Y 1 A GLN 478 ? A GLN 367 
42 1 Y 1 A ILE 479 ? A ILE 368 
43 1 Y 1 A THR 480 ? A THR 369 
44 1 Y 1 A LYS 481 ? A LYS 370 
45 1 Y 1 A GLU 482 ? A GLU 371 
46 1 Y 1 A SER 483 ? A SER 372 
47 1 Y 1 A PRO 484 ? A PRO 373 
48 1 Y 1 A ASN 485 ? A ASN 374 
49 1 Y 1 A TYR 486 ? A TYR 375 
50 1 Y 1 A SER 487 ? A SER 376 
51 1 Y 1 A PHE 488 ? A PHE 377 
52 1 Y 1 A GLY 489 ? A GLY 378 
53 1 Y 1 A ASN 490 ? A ASN 379 
54 1 Y 1 A SER 491 ? A SER 380 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1AG0 C4     C  Y N 1   
A1AG0 C5     C  Y N 2   
A1AG0 C6     C  Y N 3   
A1AG0 C8     C  Y N 4   
A1AG0 C9     C  Y N 5   
A1AG0 C12    C  Y N 6   
A1AG0 C13    C  Y N 7   
A1AG0 C3     C  Y N 8   
A1AG0 C1     C  N N 9   
A1AG0 C17    C  Y N 10  
A1AG0 C18    C  Y N 11  
A1AG0 C19    C  Y N 12  
A1AG0 C2     C  N R 13  
A1AG0 C20    C  Y N 14  
A1AG0 C21    C  Y N 15  
A1AG0 C22    C  Y N 16  
A1AG0 C23    C  Y N 17  
A1AG0 C24    C  Y N 18  
A1AG0 C25    C  Y N 19  
A1AG0 C27    C  N N 20  
A1AG0 C29    C  N N 21  
A1AG0 C30    C  N N 22  
A1AG0 N10    N  Y N 23  
A1AG0 N14    N  Y N 24  
A1AG0 N26    N  Y N 25  
A1AG0 N7     N  Y N 26  
A1AG0 O16    O  N N 27  
A1AG0 O28    O  N N 28  
A1AG0 CL15   CL N N 29  
A1AG0 H1     H  N N 30  
A1AG0 H2     H  N N 31  
A1AG0 H3     H  N N 32  
A1AG0 H4     H  N N 33  
A1AG0 H5     H  N N 34  
A1AG0 H6     H  N N 35  
A1AG0 H7     H  N N 36  
A1AG0 H8     H  N N 37  
A1AG0 H9     H  N N 38  
A1AG0 H10    H  N N 39  
A1AG0 H12    H  N N 40  
A1AG0 H13    H  N N 41  
A1AG0 H14    H  N N 42  
A1AG0 H15    H  N N 43  
A1AG0 H16    H  N N 44  
A1AG0 H17    H  N N 45  
A1AG0 H18    H  N N 46  
A1AG0 H19    H  N N 47  
A1AG0 H11    H  N N 48  
ALA   N      N  N N 49  
ALA   CA     C  N S 50  
ALA   C      C  N N 51  
ALA   O      O  N N 52  
ALA   CB     C  N N 53  
ALA   OXT    O  N N 54  
ALA   H      H  N N 55  
ALA   H2     H  N N 56  
ALA   HA     H  N N 57  
ALA   HB1    H  N N 58  
ALA   HB2    H  N N 59  
ALA   HB3    H  N N 60  
ALA   HXT    H  N N 61  
ARG   N      N  N N 62  
ARG   CA     C  N S 63  
ARG   C      C  N N 64  
ARG   O      O  N N 65  
ARG   CB     C  N N 66  
ARG   CG     C  N N 67  
ARG   CD     C  N N 68  
ARG   NE     N  N N 69  
ARG   CZ     C  N N 70  
ARG   NH1    N  N N 71  
ARG   NH2    N  N N 72  
ARG   OXT    O  N N 73  
ARG   H      H  N N 74  
ARG   H2     H  N N 75  
ARG   HA     H  N N 76  
ARG   HB2    H  N N 77  
ARG   HB3    H  N N 78  
ARG   HG2    H  N N 79  
ARG   HG3    H  N N 80  
ARG   HD2    H  N N 81  
ARG   HD3    H  N N 82  
ARG   HE     H  N N 83  
ARG   HH11   H  N N 84  
ARG   HH12   H  N N 85  
ARG   HH21   H  N N 86  
ARG   HH22   H  N N 87  
ARG   HXT    H  N N 88  
ASN   N      N  N N 89  
ASN   CA     C  N S 90  
ASN   C      C  N N 91  
ASN   O      O  N N 92  
ASN   CB     C  N N 93  
ASN   CG     C  N N 94  
ASN   OD1    O  N N 95  
ASN   ND2    N  N N 96  
ASN   OXT    O  N N 97  
ASN   H      H  N N 98  
ASN   H2     H  N N 99  
ASN   HA     H  N N 100 
ASN   HB2    H  N N 101 
ASN   HB3    H  N N 102 
ASN   HD21   H  N N 103 
ASN   HD22   H  N N 104 
ASN   HXT    H  N N 105 
ASP   N      N  N N 106 
ASP   CA     C  N S 107 
ASP   C      C  N N 108 
ASP   O      O  N N 109 
ASP   CB     C  N N 110 
ASP   CG     C  N N 111 
ASP   OD1    O  N N 112 
ASP   OD2    O  N N 113 
ASP   OXT    O  N N 114 
ASP   H      H  N N 115 
ASP   H2     H  N N 116 
ASP   HA     H  N N 117 
ASP   HB2    H  N N 118 
ASP   HB3    H  N N 119 
ASP   HD2    H  N N 120 
ASP   HXT    H  N N 121 
CYS   N      N  N N 122 
CYS   CA     C  N R 123 
CYS   C      C  N N 124 
CYS   O      O  N N 125 
CYS   CB     C  N N 126 
CYS   SG     S  N N 127 
CYS   OXT    O  N N 128 
CYS   H      H  N N 129 
CYS   H2     H  N N 130 
CYS   HA     H  N N 131 
CYS   HB2    H  N N 132 
CYS   HB3    H  N N 133 
CYS   HG     H  N N 134 
CYS   HXT    H  N N 135 
GLN   N      N  N N 136 
GLN   CA     C  N S 137 
GLN   C      C  N N 138 
GLN   O      O  N N 139 
GLN   CB     C  N N 140 
GLN   CG     C  N N 141 
GLN   CD     C  N N 142 
GLN   OE1    O  N N 143 
GLN   NE2    N  N N 144 
GLN   OXT    O  N N 145 
GLN   H      H  N N 146 
GLN   H2     H  N N 147 
GLN   HA     H  N N 148 
GLN   HB2    H  N N 149 
GLN   HB3    H  N N 150 
GLN   HG2    H  N N 151 
GLN   HG3    H  N N 152 
GLN   HE21   H  N N 153 
GLN   HE22   H  N N 154 
GLN   HXT    H  N N 155 
GLU   N      N  N N 156 
GLU   CA     C  N S 157 
GLU   C      C  N N 158 
GLU   O      O  N N 159 
GLU   CB     C  N N 160 
GLU   CG     C  N N 161 
GLU   CD     C  N N 162 
GLU   OE1    O  N N 163 
GLU   OE2    O  N N 164 
GLU   OXT    O  N N 165 
GLU   H      H  N N 166 
GLU   H2     H  N N 167 
GLU   HA     H  N N 168 
GLU   HB2    H  N N 169 
GLU   HB3    H  N N 170 
GLU   HG2    H  N N 171 
GLU   HG3    H  N N 172 
GLU   HE2    H  N N 173 
GLU   HXT    H  N N 174 
GLY   N      N  N N 175 
GLY   CA     C  N N 176 
GLY   C      C  N N 177 
GLY   O      O  N N 178 
GLY   OXT    O  N N 179 
GLY   H      H  N N 180 
GLY   H2     H  N N 181 
GLY   HA2    H  N N 182 
GLY   HA3    H  N N 183 
GLY   HXT    H  N N 184 
HIS   N      N  N N 185 
HIS   CA     C  N S 186 
HIS   C      C  N N 187 
HIS   O      O  N N 188 
HIS   CB     C  N N 189 
HIS   CG     C  Y N 190 
HIS   ND1    N  Y N 191 
HIS   CD2    C  Y N 192 
HIS   CE1    C  Y N 193 
HIS   NE2    N  Y N 194 
HIS   OXT    O  N N 195 
HIS   H      H  N N 196 
HIS   H2     H  N N 197 
HIS   HA     H  N N 198 
HIS   HB2    H  N N 199 
HIS   HB3    H  N N 200 
HIS   HD1    H  N N 201 
HIS   HD2    H  N N 202 
HIS   HE1    H  N N 203 
HIS   HE2    H  N N 204 
HIS   HXT    H  N N 205 
HOH   O      O  N N 206 
HOH   H1     H  N N 207 
HOH   H2     H  N N 208 
ILE   N      N  N N 209 
ILE   CA     C  N S 210 
ILE   C      C  N N 211 
ILE   O      O  N N 212 
ILE   CB     C  N S 213 
ILE   CG1    C  N N 214 
ILE   CG2    C  N N 215 
ILE   CD1    C  N N 216 
ILE   OXT    O  N N 217 
ILE   H      H  N N 218 
ILE   H2     H  N N 219 
ILE   HA     H  N N 220 
ILE   HB     H  N N 221 
ILE   HG12   H  N N 222 
ILE   HG13   H  N N 223 
ILE   HG21   H  N N 224 
ILE   HG22   H  N N 225 
ILE   HG23   H  N N 226 
ILE   HD11   H  N N 227 
ILE   HD12   H  N N 228 
ILE   HD13   H  N N 229 
ILE   HXT    H  N N 230 
IMP   P      P  N N 231 
IMP   O1P    O  N N 232 
IMP   O2P    O  N N 233 
IMP   O3P    O  N N 234 
IMP   "O5'"  O  N N 235 
IMP   "C5'"  C  N N 236 
IMP   "C4'"  C  N R 237 
IMP   "O4'"  O  N N 238 
IMP   "C3'"  C  N S 239 
IMP   "O3'"  O  N N 240 
IMP   "C2'"  C  N R 241 
IMP   "O2'"  O  N N 242 
IMP   "C1'"  C  N R 243 
IMP   N9     N  Y N 244 
IMP   C8     C  Y N 245 
IMP   N7     N  Y N 246 
IMP   C5     C  Y N 247 
IMP   C6     C  N N 248 
IMP   O6     O  N N 249 
IMP   N1     N  N N 250 
IMP   C2     C  N N 251 
IMP   N3     N  N N 252 
IMP   C4     C  Y N 253 
IMP   HOP2   H  N N 254 
IMP   HOP3   H  N N 255 
IMP   "H5'1" H  N N 256 
IMP   "H5'2" H  N N 257 
IMP   "H4'"  H  N N 258 
IMP   "H3'"  H  N N 259 
IMP   "HO3'" H  N N 260 
IMP   "H2'"  H  N N 261 
IMP   "HO2'" H  N N 262 
IMP   "H1'"  H  N N 263 
IMP   H8     H  N N 264 
IMP   HN1    H  N N 265 
IMP   H2     H  N N 266 
LEU   N      N  N N 267 
LEU   CA     C  N S 268 
LEU   C      C  N N 269 
LEU   O      O  N N 270 
LEU   CB     C  N N 271 
LEU   CG     C  N N 272 
LEU   CD1    C  N N 273 
LEU   CD2    C  N N 274 
LEU   OXT    O  N N 275 
LEU   H      H  N N 276 
LEU   H2     H  N N 277 
LEU   HA     H  N N 278 
LEU   HB2    H  N N 279 
LEU   HB3    H  N N 280 
LEU   HG     H  N N 281 
LEU   HD11   H  N N 282 
LEU   HD12   H  N N 283 
LEU   HD13   H  N N 284 
LEU   HD21   H  N N 285 
LEU   HD22   H  N N 286 
LEU   HD23   H  N N 287 
LEU   HXT    H  N N 288 
LYS   N      N  N N 289 
LYS   CA     C  N S 290 
LYS   C      C  N N 291 
LYS   O      O  N N 292 
LYS   CB     C  N N 293 
LYS   CG     C  N N 294 
LYS   CD     C  N N 295 
LYS   CE     C  N N 296 
LYS   NZ     N  N N 297 
LYS   OXT    O  N N 298 
LYS   H      H  N N 299 
LYS   H2     H  N N 300 
LYS   HA     H  N N 301 
LYS   HB2    H  N N 302 
LYS   HB3    H  N N 303 
LYS   HG2    H  N N 304 
LYS   HG3    H  N N 305 
LYS   HD2    H  N N 306 
LYS   HD3    H  N N 307 
LYS   HE2    H  N N 308 
LYS   HE3    H  N N 309 
LYS   HZ1    H  N N 310 
LYS   HZ2    H  N N 311 
LYS   HZ3    H  N N 312 
LYS   HXT    H  N N 313 
MET   N      N  N N 314 
MET   CA     C  N S 315 
MET   C      C  N N 316 
MET   O      O  N N 317 
MET   CB     C  N N 318 
MET   CG     C  N N 319 
MET   SD     S  N N 320 
MET   CE     C  N N 321 
MET   OXT    O  N N 322 
MET   H      H  N N 323 
MET   H2     H  N N 324 
MET   HA     H  N N 325 
MET   HB2    H  N N 326 
MET   HB3    H  N N 327 
MET   HG2    H  N N 328 
MET   HG3    H  N N 329 
MET   HE1    H  N N 330 
MET   HE2    H  N N 331 
MET   HE3    H  N N 332 
MET   HXT    H  N N 333 
PHE   N      N  N N 334 
PHE   CA     C  N S 335 
PHE   C      C  N N 336 
PHE   O      O  N N 337 
PHE   CB     C  N N 338 
PHE   CG     C  Y N 339 
PHE   CD1    C  Y N 340 
PHE   CD2    C  Y N 341 
PHE   CE1    C  Y N 342 
PHE   CE2    C  Y N 343 
PHE   CZ     C  Y N 344 
PHE   OXT    O  N N 345 
PHE   H      H  N N 346 
PHE   H2     H  N N 347 
PHE   HA     H  N N 348 
PHE   HB2    H  N N 349 
PHE   HB3    H  N N 350 
PHE   HD1    H  N N 351 
PHE   HD2    H  N N 352 
PHE   HE1    H  N N 353 
PHE   HE2    H  N N 354 
PHE   HZ     H  N N 355 
PHE   HXT    H  N N 356 
PRO   N      N  N N 357 
PRO   CA     C  N S 358 
PRO   C      C  N N 359 
PRO   O      O  N N 360 
PRO   CB     C  N N 361 
PRO   CG     C  N N 362 
PRO   CD     C  N N 363 
PRO   OXT    O  N N 364 
PRO   H      H  N N 365 
PRO   HA     H  N N 366 
PRO   HB2    H  N N 367 
PRO   HB3    H  N N 368 
PRO   HG2    H  N N 369 
PRO   HG3    H  N N 370 
PRO   HD2    H  N N 371 
PRO   HD3    H  N N 372 
PRO   HXT    H  N N 373 
SER   N      N  N N 374 
SER   CA     C  N S 375 
SER   C      C  N N 376 
SER   O      O  N N 377 
SER   CB     C  N N 378 
SER   OG     O  N N 379 
SER   OXT    O  N N 380 
SER   H      H  N N 381 
SER   H2     H  N N 382 
SER   HA     H  N N 383 
SER   HB2    H  N N 384 
SER   HB3    H  N N 385 
SER   HG     H  N N 386 
SER   HXT    H  N N 387 
THR   N      N  N N 388 
THR   CA     C  N S 389 
THR   C      C  N N 390 
THR   O      O  N N 391 
THR   CB     C  N R 392 
THR   OG1    O  N N 393 
THR   CG2    C  N N 394 
THR   OXT    O  N N 395 
THR   H      H  N N 396 
THR   H2     H  N N 397 
THR   HA     H  N N 398 
THR   HB     H  N N 399 
THR   HG1    H  N N 400 
THR   HG21   H  N N 401 
THR   HG22   H  N N 402 
THR   HG23   H  N N 403 
THR   HXT    H  N N 404 
TRP   N      N  N N 405 
TRP   CA     C  N S 406 
TRP   C      C  N N 407 
TRP   O      O  N N 408 
TRP   CB     C  N N 409 
TRP   CG     C  Y N 410 
TRP   CD1    C  Y N 411 
TRP   CD2    C  Y N 412 
TRP   NE1    N  Y N 413 
TRP   CE2    C  Y N 414 
TRP   CE3    C  Y N 415 
TRP   CZ2    C  Y N 416 
TRP   CZ3    C  Y N 417 
TRP   CH2    C  Y N 418 
TRP   OXT    O  N N 419 
TRP   H      H  N N 420 
TRP   H2     H  N N 421 
TRP   HA     H  N N 422 
TRP   HB2    H  N N 423 
TRP   HB3    H  N N 424 
TRP   HD1    H  N N 425 
TRP   HE1    H  N N 426 
TRP   HE3    H  N N 427 
TRP   HZ2    H  N N 428 
TRP   HZ3    H  N N 429 
TRP   HH2    H  N N 430 
TRP   HXT    H  N N 431 
TYR   N      N  N N 432 
TYR   CA     C  N S 433 
TYR   C      C  N N 434 
TYR   O      O  N N 435 
TYR   CB     C  N N 436 
TYR   CG     C  Y N 437 
TYR   CD1    C  Y N 438 
TYR   CD2    C  Y N 439 
TYR   CE1    C  Y N 440 
TYR   CE2    C  Y N 441 
TYR   CZ     C  Y N 442 
TYR   OH     O  N N 443 
TYR   OXT    O  N N 444 
TYR   H      H  N N 445 
TYR   H2     H  N N 446 
TYR   HA     H  N N 447 
TYR   HB2    H  N N 448 
TYR   HB3    H  N N 449 
TYR   HD1    H  N N 450 
TYR   HD2    H  N N 451 
TYR   HE1    H  N N 452 
TYR   HE2    H  N N 453 
TYR   HH     H  N N 454 
TYR   HXT    H  N N 455 
VAL   N      N  N N 456 
VAL   CA     C  N S 457 
VAL   C      C  N N 458 
VAL   O      O  N N 459 
VAL   CB     C  N N 460 
VAL   CG1    C  N N 461 
VAL   CG2    C  N N 462 
VAL   OXT    O  N N 463 
VAL   H      H  N N 464 
VAL   H2     H  N N 465 
VAL   HA     H  N N 466 
VAL   HB     H  N N 467 
VAL   HG11   H  N N 468 
VAL   HG12   H  N N 469 
VAL   HG13   H  N N 470 
VAL   HG21   H  N N 471 
VAL   HG22   H  N N 472 
VAL   HG23   H  N N 473 
VAL   HXT    H  N N 474 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1AG0 C12   N10    sing Y N 1   
A1AG0 C12   C13    doub Y N 2   
A1AG0 C29   O28    sing N N 3   
A1AG0 C29   C30    sing N N 4   
A1AG0 N10   C9     sing Y N 5   
A1AG0 CL15  C13    sing N N 6   
A1AG0 O28   C27    sing N N 7   
A1AG0 C13   N14    sing Y N 8   
A1AG0 C30   C23    sing N N 9   
A1AG0 C9    N14    doub Y N 10  
A1AG0 C9    C5     sing N N 11  
A1AG0 C27   C24    sing N N 12  
A1AG0 C23   C24    doub Y N 13  
A1AG0 C23   C21    sing Y N 14  
A1AG0 C22   C21    doub Y N 15  
A1AG0 C22   C17    sing Y N 16  
A1AG0 C4    C5     doub Y N 17  
A1AG0 C4    C3     sing Y N 18  
A1AG0 C1    C2     sing N N 19  
A1AG0 C5    C6     sing Y N 20  
A1AG0 C24   C25    sing Y N 21  
A1AG0 O16   C17    sing N N 22  
A1AG0 O16   C2     sing N N 23  
A1AG0 C21   C20    sing Y N 24  
A1AG0 C17   C18    doub Y N 25  
A1AG0 C2    C3     sing N N 26  
A1AG0 C3    C8     doub Y N 27  
A1AG0 C6    N7     doub Y N 28  
A1AG0 C25   N26    doub Y N 29  
A1AG0 C20   N26    sing Y N 30  
A1AG0 C20   C19    doub Y N 31  
A1AG0 C18   C19    sing Y N 32  
A1AG0 C8    N7     sing Y N 33  
A1AG0 C4    H1     sing N N 34  
A1AG0 C6    H2     sing N N 35  
A1AG0 C8    H3     sing N N 36  
A1AG0 C12   H4     sing N N 37  
A1AG0 C1    H5     sing N N 38  
A1AG0 C1    H6     sing N N 39  
A1AG0 C1    H7     sing N N 40  
A1AG0 C18   H8     sing N N 41  
A1AG0 C19   H9     sing N N 42  
A1AG0 C2    H10    sing N N 43  
A1AG0 C22   H12    sing N N 44  
A1AG0 C25   H13    sing N N 45  
A1AG0 C27   H14    sing N N 46  
A1AG0 C27   H15    sing N N 47  
A1AG0 C29   H16    sing N N 48  
A1AG0 C29   H17    sing N N 49  
A1AG0 C30   H18    sing N N 50  
A1AG0 C30   H19    sing N N 51  
A1AG0 N10   H11    sing N N 52  
ALA   N     CA     sing N N 53  
ALA   N     H      sing N N 54  
ALA   N     H2     sing N N 55  
ALA   CA    C      sing N N 56  
ALA   CA    CB     sing N N 57  
ALA   CA    HA     sing N N 58  
ALA   C     O      doub N N 59  
ALA   C     OXT    sing N N 60  
ALA   CB    HB1    sing N N 61  
ALA   CB    HB2    sing N N 62  
ALA   CB    HB3    sing N N 63  
ALA   OXT   HXT    sing N N 64  
ARG   N     CA     sing N N 65  
ARG   N     H      sing N N 66  
ARG   N     H2     sing N N 67  
ARG   CA    C      sing N N 68  
ARG   CA    CB     sing N N 69  
ARG   CA    HA     sing N N 70  
ARG   C     O      doub N N 71  
ARG   C     OXT    sing N N 72  
ARG   CB    CG     sing N N 73  
ARG   CB    HB2    sing N N 74  
ARG   CB    HB3    sing N N 75  
ARG   CG    CD     sing N N 76  
ARG   CG    HG2    sing N N 77  
ARG   CG    HG3    sing N N 78  
ARG   CD    NE     sing N N 79  
ARG   CD    HD2    sing N N 80  
ARG   CD    HD3    sing N N 81  
ARG   NE    CZ     sing N N 82  
ARG   NE    HE     sing N N 83  
ARG   CZ    NH1    sing N N 84  
ARG   CZ    NH2    doub N N 85  
ARG   NH1   HH11   sing N N 86  
ARG   NH1   HH12   sing N N 87  
ARG   NH2   HH21   sing N N 88  
ARG   NH2   HH22   sing N N 89  
ARG   OXT   HXT    sing N N 90  
ASN   N     CA     sing N N 91  
ASN   N     H      sing N N 92  
ASN   N     H2     sing N N 93  
ASN   CA    C      sing N N 94  
ASN   CA    CB     sing N N 95  
ASN   CA    HA     sing N N 96  
ASN   C     O      doub N N 97  
ASN   C     OXT    sing N N 98  
ASN   CB    CG     sing N N 99  
ASN   CB    HB2    sing N N 100 
ASN   CB    HB3    sing N N 101 
ASN   CG    OD1    doub N N 102 
ASN   CG    ND2    sing N N 103 
ASN   ND2   HD21   sing N N 104 
ASN   ND2   HD22   sing N N 105 
ASN   OXT   HXT    sing N N 106 
ASP   N     CA     sing N N 107 
ASP   N     H      sing N N 108 
ASP   N     H2     sing N N 109 
ASP   CA    C      sing N N 110 
ASP   CA    CB     sing N N 111 
ASP   CA    HA     sing N N 112 
ASP   C     O      doub N N 113 
ASP   C     OXT    sing N N 114 
ASP   CB    CG     sing N N 115 
ASP   CB    HB2    sing N N 116 
ASP   CB    HB3    sing N N 117 
ASP   CG    OD1    doub N N 118 
ASP   CG    OD2    sing N N 119 
ASP   OD2   HD2    sing N N 120 
ASP   OXT   HXT    sing N N 121 
CYS   N     CA     sing N N 122 
CYS   N     H      sing N N 123 
CYS   N     H2     sing N N 124 
CYS   CA    C      sing N N 125 
CYS   CA    CB     sing N N 126 
CYS   CA    HA     sing N N 127 
CYS   C     O      doub N N 128 
CYS   C     OXT    sing N N 129 
CYS   CB    SG     sing N N 130 
CYS   CB    HB2    sing N N 131 
CYS   CB    HB3    sing N N 132 
CYS   SG    HG     sing N N 133 
CYS   OXT   HXT    sing N N 134 
GLN   N     CA     sing N N 135 
GLN   N     H      sing N N 136 
GLN   N     H2     sing N N 137 
GLN   CA    C      sing N N 138 
GLN   CA    CB     sing N N 139 
GLN   CA    HA     sing N N 140 
GLN   C     O      doub N N 141 
GLN   C     OXT    sing N N 142 
GLN   CB    CG     sing N N 143 
GLN   CB    HB2    sing N N 144 
GLN   CB    HB3    sing N N 145 
GLN   CG    CD     sing N N 146 
GLN   CG    HG2    sing N N 147 
GLN   CG    HG3    sing N N 148 
GLN   CD    OE1    doub N N 149 
GLN   CD    NE2    sing N N 150 
GLN   NE2   HE21   sing N N 151 
GLN   NE2   HE22   sing N N 152 
GLN   OXT   HXT    sing N N 153 
GLU   N     CA     sing N N 154 
GLU   N     H      sing N N 155 
GLU   N     H2     sing N N 156 
GLU   CA    C      sing N N 157 
GLU   CA    CB     sing N N 158 
GLU   CA    HA     sing N N 159 
GLU   C     O      doub N N 160 
GLU   C     OXT    sing N N 161 
GLU   CB    CG     sing N N 162 
GLU   CB    HB2    sing N N 163 
GLU   CB    HB3    sing N N 164 
GLU   CG    CD     sing N N 165 
GLU   CG    HG2    sing N N 166 
GLU   CG    HG3    sing N N 167 
GLU   CD    OE1    doub N N 168 
GLU   CD    OE2    sing N N 169 
GLU   OE2   HE2    sing N N 170 
GLU   OXT   HXT    sing N N 171 
GLY   N     CA     sing N N 172 
GLY   N     H      sing N N 173 
GLY   N     H2     sing N N 174 
GLY   CA    C      sing N N 175 
GLY   CA    HA2    sing N N 176 
GLY   CA    HA3    sing N N 177 
GLY   C     O      doub N N 178 
GLY   C     OXT    sing N N 179 
GLY   OXT   HXT    sing N N 180 
HIS   N     CA     sing N N 181 
HIS   N     H      sing N N 182 
HIS   N     H2     sing N N 183 
HIS   CA    C      sing N N 184 
HIS   CA    CB     sing N N 185 
HIS   CA    HA     sing N N 186 
HIS   C     O      doub N N 187 
HIS   C     OXT    sing N N 188 
HIS   CB    CG     sing N N 189 
HIS   CB    HB2    sing N N 190 
HIS   CB    HB3    sing N N 191 
HIS   CG    ND1    sing Y N 192 
HIS   CG    CD2    doub Y N 193 
HIS   ND1   CE1    doub Y N 194 
HIS   ND1   HD1    sing N N 195 
HIS   CD2   NE2    sing Y N 196 
HIS   CD2   HD2    sing N N 197 
HIS   CE1   NE2    sing Y N 198 
HIS   CE1   HE1    sing N N 199 
HIS   NE2   HE2    sing N N 200 
HIS   OXT   HXT    sing N N 201 
HOH   O     H1     sing N N 202 
HOH   O     H2     sing N N 203 
ILE   N     CA     sing N N 204 
ILE   N     H      sing N N 205 
ILE   N     H2     sing N N 206 
ILE   CA    C      sing N N 207 
ILE   CA    CB     sing N N 208 
ILE   CA    HA     sing N N 209 
ILE   C     O      doub N N 210 
ILE   C     OXT    sing N N 211 
ILE   CB    CG1    sing N N 212 
ILE   CB    CG2    sing N N 213 
ILE   CB    HB     sing N N 214 
ILE   CG1   CD1    sing N N 215 
ILE   CG1   HG12   sing N N 216 
ILE   CG1   HG13   sing N N 217 
ILE   CG2   HG21   sing N N 218 
ILE   CG2   HG22   sing N N 219 
ILE   CG2   HG23   sing N N 220 
ILE   CD1   HD11   sing N N 221 
ILE   CD1   HD12   sing N N 222 
ILE   CD1   HD13   sing N N 223 
ILE   OXT   HXT    sing N N 224 
IMP   P     O1P    doub N N 225 
IMP   P     O2P    sing N N 226 
IMP   P     O3P    sing N N 227 
IMP   P     "O5'"  sing N N 228 
IMP   O2P   HOP2   sing N N 229 
IMP   O3P   HOP3   sing N N 230 
IMP   "O5'" "C5'"  sing N N 231 
IMP   "C5'" "C4'"  sing N N 232 
IMP   "C5'" "H5'1" sing N N 233 
IMP   "C5'" "H5'2" sing N N 234 
IMP   "C4'" "O4'"  sing N N 235 
IMP   "C4'" "C3'"  sing N N 236 
IMP   "C4'" "H4'"  sing N N 237 
IMP   "O4'" "C1'"  sing N N 238 
IMP   "C3'" "O3'"  sing N N 239 
IMP   "C3'" "C2'"  sing N N 240 
IMP   "C3'" "H3'"  sing N N 241 
IMP   "O3'" "HO3'" sing N N 242 
IMP   "C2'" "O2'"  sing N N 243 
IMP   "C2'" "C1'"  sing N N 244 
IMP   "C2'" "H2'"  sing N N 245 
IMP   "O2'" "HO2'" sing N N 246 
IMP   "C1'" N9     sing N N 247 
IMP   "C1'" "H1'"  sing N N 248 
IMP   N9    C8     sing Y N 249 
IMP   N9    C4     sing Y N 250 
IMP   C8    N7     doub Y N 251 
IMP   C8    H8     sing N N 252 
IMP   N7    C5     sing Y N 253 
IMP   C5    C6     sing N N 254 
IMP   C5    C4     doub Y N 255 
IMP   C6    O6     doub N N 256 
IMP   C6    N1     sing N N 257 
IMP   N1    C2     sing N N 258 
IMP   N1    HN1    sing N N 259 
IMP   C2    N3     doub N N 260 
IMP   C2    H2     sing N N 261 
IMP   N3    C4     sing N N 262 
LEU   N     CA     sing N N 263 
LEU   N     H      sing N N 264 
LEU   N     H2     sing N N 265 
LEU   CA    C      sing N N 266 
LEU   CA    CB     sing N N 267 
LEU   CA    HA     sing N N 268 
LEU   C     O      doub N N 269 
LEU   C     OXT    sing N N 270 
LEU   CB    CG     sing N N 271 
LEU   CB    HB2    sing N N 272 
LEU   CB    HB3    sing N N 273 
LEU   CG    CD1    sing N N 274 
LEU   CG    CD2    sing N N 275 
LEU   CG    HG     sing N N 276 
LEU   CD1   HD11   sing N N 277 
LEU   CD1   HD12   sing N N 278 
LEU   CD1   HD13   sing N N 279 
LEU   CD2   HD21   sing N N 280 
LEU   CD2   HD22   sing N N 281 
LEU   CD2   HD23   sing N N 282 
LEU   OXT   HXT    sing N N 283 
LYS   N     CA     sing N N 284 
LYS   N     H      sing N N 285 
LYS   N     H2     sing N N 286 
LYS   CA    C      sing N N 287 
LYS   CA    CB     sing N N 288 
LYS   CA    HA     sing N N 289 
LYS   C     O      doub N N 290 
LYS   C     OXT    sing N N 291 
LYS   CB    CG     sing N N 292 
LYS   CB    HB2    sing N N 293 
LYS   CB    HB3    sing N N 294 
LYS   CG    CD     sing N N 295 
LYS   CG    HG2    sing N N 296 
LYS   CG    HG3    sing N N 297 
LYS   CD    CE     sing N N 298 
LYS   CD    HD2    sing N N 299 
LYS   CD    HD3    sing N N 300 
LYS   CE    NZ     sing N N 301 
LYS   CE    HE2    sing N N 302 
LYS   CE    HE3    sing N N 303 
LYS   NZ    HZ1    sing N N 304 
LYS   NZ    HZ2    sing N N 305 
LYS   NZ    HZ3    sing N N 306 
LYS   OXT   HXT    sing N N 307 
MET   N     CA     sing N N 308 
MET   N     H      sing N N 309 
MET   N     H2     sing N N 310 
MET   CA    C      sing N N 311 
MET   CA    CB     sing N N 312 
MET   CA    HA     sing N N 313 
MET   C     O      doub N N 314 
MET   C     OXT    sing N N 315 
MET   CB    CG     sing N N 316 
MET   CB    HB2    sing N N 317 
MET   CB    HB3    sing N N 318 
MET   CG    SD     sing N N 319 
MET   CG    HG2    sing N N 320 
MET   CG    HG3    sing N N 321 
MET   SD    CE     sing N N 322 
MET   CE    HE1    sing N N 323 
MET   CE    HE2    sing N N 324 
MET   CE    HE3    sing N N 325 
MET   OXT   HXT    sing N N 326 
PHE   N     CA     sing N N 327 
PHE   N     H      sing N N 328 
PHE   N     H2     sing N N 329 
PHE   CA    C      sing N N 330 
PHE   CA    CB     sing N N 331 
PHE   CA    HA     sing N N 332 
PHE   C     O      doub N N 333 
PHE   C     OXT    sing N N 334 
PHE   CB    CG     sing N N 335 
PHE   CB    HB2    sing N N 336 
PHE   CB    HB3    sing N N 337 
PHE   CG    CD1    doub Y N 338 
PHE   CG    CD2    sing Y N 339 
PHE   CD1   CE1    sing Y N 340 
PHE   CD1   HD1    sing N N 341 
PHE   CD2   CE2    doub Y N 342 
PHE   CD2   HD2    sing N N 343 
PHE   CE1   CZ     doub Y N 344 
PHE   CE1   HE1    sing N N 345 
PHE   CE2   CZ     sing Y N 346 
PHE   CE2   HE2    sing N N 347 
PHE   CZ    HZ     sing N N 348 
PHE   OXT   HXT    sing N N 349 
PRO   N     CA     sing N N 350 
PRO   N     CD     sing N N 351 
PRO   N     H      sing N N 352 
PRO   CA    C      sing N N 353 
PRO   CA    CB     sing N N 354 
PRO   CA    HA     sing N N 355 
PRO   C     O      doub N N 356 
PRO   C     OXT    sing N N 357 
PRO   CB    CG     sing N N 358 
PRO   CB    HB2    sing N N 359 
PRO   CB    HB3    sing N N 360 
PRO   CG    CD     sing N N 361 
PRO   CG    HG2    sing N N 362 
PRO   CG    HG3    sing N N 363 
PRO   CD    HD2    sing N N 364 
PRO   CD    HD3    sing N N 365 
PRO   OXT   HXT    sing N N 366 
SER   N     CA     sing N N 367 
SER   N     H      sing N N 368 
SER   N     H2     sing N N 369 
SER   CA    C      sing N N 370 
SER   CA    CB     sing N N 371 
SER   CA    HA     sing N N 372 
SER   C     O      doub N N 373 
SER   C     OXT    sing N N 374 
SER   CB    OG     sing N N 375 
SER   CB    HB2    sing N N 376 
SER   CB    HB3    sing N N 377 
SER   OG    HG     sing N N 378 
SER   OXT   HXT    sing N N 379 
THR   N     CA     sing N N 380 
THR   N     H      sing N N 381 
THR   N     H2     sing N N 382 
THR   CA    C      sing N N 383 
THR   CA    CB     sing N N 384 
THR   CA    HA     sing N N 385 
THR   C     O      doub N N 386 
THR   C     OXT    sing N N 387 
THR   CB    OG1    sing N N 388 
THR   CB    CG2    sing N N 389 
THR   CB    HB     sing N N 390 
THR   OG1   HG1    sing N N 391 
THR   CG2   HG21   sing N N 392 
THR   CG2   HG22   sing N N 393 
THR   CG2   HG23   sing N N 394 
THR   OXT   HXT    sing N N 395 
TRP   N     CA     sing N N 396 
TRP   N     H      sing N N 397 
TRP   N     H2     sing N N 398 
TRP   CA    C      sing N N 399 
TRP   CA    CB     sing N N 400 
TRP   CA    HA     sing N N 401 
TRP   C     O      doub N N 402 
TRP   C     OXT    sing N N 403 
TRP   CB    CG     sing N N 404 
TRP   CB    HB2    sing N N 405 
TRP   CB    HB3    sing N N 406 
TRP   CG    CD1    doub Y N 407 
TRP   CG    CD2    sing Y N 408 
TRP   CD1   NE1    sing Y N 409 
TRP   CD1   HD1    sing N N 410 
TRP   CD2   CE2    doub Y N 411 
TRP   CD2   CE3    sing Y N 412 
TRP   NE1   CE2    sing Y N 413 
TRP   NE1   HE1    sing N N 414 
TRP   CE2   CZ2    sing Y N 415 
TRP   CE3   CZ3    doub Y N 416 
TRP   CE3   HE3    sing N N 417 
TRP   CZ2   CH2    doub Y N 418 
TRP   CZ2   HZ2    sing N N 419 
TRP   CZ3   CH2    sing Y N 420 
TRP   CZ3   HZ3    sing N N 421 
TRP   CH2   HH2    sing N N 422 
TRP   OXT   HXT    sing N N 423 
TYR   N     CA     sing N N 424 
TYR   N     H      sing N N 425 
TYR   N     H2     sing N N 426 
TYR   CA    C      sing N N 427 
TYR   CA    CB     sing N N 428 
TYR   CA    HA     sing N N 429 
TYR   C     O      doub N N 430 
TYR   C     OXT    sing N N 431 
TYR   CB    CG     sing N N 432 
TYR   CB    HB2    sing N N 433 
TYR   CB    HB3    sing N N 434 
TYR   CG    CD1    doub Y N 435 
TYR   CG    CD2    sing Y N 436 
TYR   CD1   CE1    sing Y N 437 
TYR   CD1   HD1    sing N N 438 
TYR   CD2   CE2    doub Y N 439 
TYR   CD2   HD2    sing N N 440 
TYR   CE1   CZ     doub Y N 441 
TYR   CE1   HE1    sing N N 442 
TYR   CE2   CZ     sing Y N 443 
TYR   CE2   HE2    sing N N 444 
TYR   CZ    OH     sing N N 445 
TYR   OH    HH     sing N N 446 
TYR   OXT   HXT    sing N N 447 
VAL   N     CA     sing N N 448 
VAL   N     H      sing N N 449 
VAL   N     H2     sing N N 450 
VAL   CA    C      sing N N 451 
VAL   CA    CB     sing N N 452 
VAL   CA    HA     sing N N 453 
VAL   C     O      doub N N 454 
VAL   C     OXT    sing N N 455 
VAL   CB    CG1    sing N N 456 
VAL   CB    CG2    sing N N 457 
VAL   CB    HB     sing N N 458 
VAL   CG1   HG11   sing N N 459 
VAL   CG1   HG12   sing N N 460 
VAL   CG1   HG13   sing N N 461 
VAL   CG2   HG21   sing N N 462 
VAL   CG2   HG22   sing N N 463 
VAL   CG2   HG23   sing N N 464 
VAL   OXT   HXT    sing N N 465 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          'in-house model' 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.source_name      Other 
_pdbx_initial_refinement_model.type             'experimental model' 
# 
_atom_sites.entry_id                    9AV0 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.009575 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.009575 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.015525 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
CL 
H  
N  
O  
P  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N      . GLY   A 1 15  ? 119.442 91.391  10.712  1.00 62.64  ?  0   GLY   A N      1 
ATOM   2    C  CA     . GLY   A 1 15  ? 120.773 91.373  10.120  1.00 62.22  ?  0   GLY   A CA     1 
ATOM   3    C  C      . GLY   A 1 15  ? 120.829 91.897  8.696   1.00 64.75  ?  0   GLY   A C      1 
ATOM   4    O  O      . GLY   A 1 15  ? 119.964 92.683  8.289   1.00 64.38  ?  0   GLY   A O      1 
ATOM   5    N  N      A SER   A 1 16  ? 121.859 91.469  7.932   0.54 59.78  ?  1   SER   A N      1 
ATOM   6    N  N      B SER   A 1 16  ? 121.857 91.462  7.937   0.46 60.52  ?  1   SER   A N      1 
ATOM   7    C  CA     A SER   A 1 16  ? 122.062 91.868  6.535   0.54 58.64  ?  1   SER   A CA     1 
ATOM   8    C  CA     B SER   A 1 16  ? 122.087 91.843  6.540   0.46 59.78  ?  1   SER   A CA     1 
ATOM   9    C  C      A SER   A 1 16  ? 121.007 91.281  5.587   0.54 61.22  ?  1   SER   A C      1 
ATOM   10   C  C      B SER   A 1 16  ? 121.011 91.284  5.597   0.46 61.70  ?  1   SER   A C      1 
ATOM   11   O  O      A SER   A 1 16  ? 120.723 91.878  4.549   0.54 61.14  ?  1   SER   A O      1 
ATOM   12   O  O      B SER   A 1 16  ? 120.725 91.895  4.568   0.46 61.57  ?  1   SER   A O      1 
ATOM   13   C  CB     A SER   A 1 16  ? 123.470 91.521  6.068   0.54 60.78  ?  1   SER   A CB     1 
ATOM   14   C  CB     B SER   A 1 16  ? 123.472 91.397  6.086   0.46 63.49  ?  1   SER   A CB     1 
ATOM   15   O  OG     A SER   A 1 16  ? 124.375 92.560  6.403   0.54 65.67  ?  1   SER   A OG     1 
ATOM   16   O  OG     B SER   A 1 16  ? 123.619 89.991  6.204   0.46 73.88  ?  1   SER   A OG     1 
ATOM   17   N  N      . TRP   A 1 17  ? 120.427 90.127  5.952   1.00 56.43  ?  2   TRP   A N      1 
ATOM   18   C  CA     . TRP   A 1 17  ? 119.372 89.455  5.191   1.00 54.83  ?  2   TRP   A CA     1 
ATOM   19   C  C      . TRP   A 1 17  ? 118.063 90.249  5.310   1.00 58.26  ?  2   TRP   A C      1 
ATOM   20   O  O      . TRP   A 1 17  ? 117.336 90.397  4.327   1.00 58.54  ?  2   TRP   A O      1 
ATOM   21   C  CB     . TRP   A 1 17  ? 119.166 88.027  5.730   1.00 52.64  ?  2   TRP   A CB     1 
ATOM   22   C  CG     . TRP   A 1 17  ? 118.081 87.264  5.025   1.00 52.77  ?  2   TRP   A CG     1 
ATOM   23   C  CD1    . TRP   A 1 17  ? 116.799 87.064  5.458   1.00 55.28  ?  2   TRP   A CD1    1 
ATOM   24   C  CD2    . TRP   A 1 17  ? 118.185 86.604  3.761   1.00 52.17  ?  2   TRP   A CD2    1 
ATOM   25   N  NE1    . TRP   A 1 17  ? 116.097 86.329  4.534   1.00 54.15  ?  2   TRP   A NE1    1 
ATOM   26   C  CE2    . TRP   A 1 17  ? 116.932 86.004  3.496   1.00 55.47  ?  2   TRP   A CE2    1 
ATOM   27   C  CE3    . TRP   A 1 17  ? 119.233 86.415  2.845   1.00 53.27  ?  2   TRP   A CE3    1 
ATOM   28   C  CZ2    . TRP   A 1 17  ? 116.680 85.284  2.323   1.00 54.37  ?  2   TRP   A CZ2    1 
ATOM   29   C  CZ3    . TRP   A 1 17  ? 118.982 85.699  1.681   1.00 54.48  ?  2   TRP   A CZ3    1 
ATOM   30   C  CH2    . TRP   A 1 17  ? 117.716 85.150  1.428   1.00 54.91  ?  2   TRP   A CH2    1 
ATOM   31   N  N      . GLU   A 1 18  ? 117.793 90.768  6.516   1.00 52.82  ?  3   GLU   A N      1 
ATOM   32   C  CA     . GLU   A 1 18  ? 116.597 91.520  6.888   1.00 51.78  ?  3   GLU   A CA     1 
ATOM   33   C  C      . GLU   A 1 18  ? 116.551 92.920  6.288   1.00 53.51  ?  3   GLU   A C      1 
ATOM   34   O  O      . GLU   A 1 18  ? 115.459 93.431  6.059   1.00 53.43  ?  3   GLU   A O      1 
ATOM   35   C  CB     . GLU   A 1 18  ? 116.466 91.589  8.430   1.00 52.88  ?  3   GLU   A CB     1 
ATOM   36   C  CG     . GLU   A 1 18  ? 116.078 90.275  9.106   1.00 58.59  ?  3   GLU   A CG     1 
ATOM   37   C  CD     . GLU   A 1 18  ? 117.047 89.103  9.046   1.00 80.00  ?  3   GLU   A CD     1 
ATOM   38   O  OE1    . GLU   A 1 18  ? 118.278 89.330  8.994   1.00 79.65  ?  3   GLU   A OE1    1 
ATOM   39   O  OE2    . GLU   A 1 18  ? 116.567 87.947  9.056   1.00 74.08  -1 3   GLU   A OE2    1 
ATOM   40   N  N      . SER   A 1 19  ? 117.718 93.545  6.061   1.00 48.54  ?  4   SER   A N      1 
ATOM   41   C  CA     . SER   A 1 19  ? 117.835 94.903  5.522   1.00 47.66  ?  4   SER   A CA     1 
ATOM   42   C  C      . SER   A 1 19  ? 118.045 94.940  4.002   1.00 51.35  ?  4   SER   A C      1 
ATOM   43   O  O      . SER   A 1 19  ? 118.235 96.024  3.436   1.00 50.66  ?  4   SER   A O      1 
ATOM   44   C  CB     . SER   A 1 19  ? 118.979 95.639  6.211   1.00 49.85  ?  4   SER   A CB     1 
ATOM   45   O  OG     . SER   A 1 19  ? 120.209 94.971  5.990   1.00 57.12  ?  4   SER   A OG     1 
ATOM   46   N  N      . LYS   A 1 20  ? 118.009 93.766  3.348   1.00 48.22  ?  5   LYS   A N      1 
ATOM   47   C  CA     . LYS   A 1 20  ? 118.223 93.599  1.903   1.00 48.10  ?  5   LYS   A CA     1 
ATOM   48   C  C      . LYS   A 1 20  ? 117.527 94.615  1.011   1.00 51.32  ?  5   LYS   A C      1 
ATOM   49   O  O      . LYS   A 1 20  ? 118.157 95.149  0.103   1.00 52.15  ?  5   LYS   A O      1 
ATOM   50   C  CB     . LYS   A 1 20  ? 117.832 92.194  1.464   1.00 50.69  ?  5   LYS   A CB     1 
ATOM   51   C  CG     . LYS   A 1 20  ? 118.976 91.216  1.580   1.00 61.16  ?  5   LYS   A CG     1 
ATOM   52   C  CD     . LYS   A 1 20  ? 118.793 90.043  0.646   1.00 59.11  ?  5   LYS   A CD     1 
ATOM   53   C  CE     . LYS   A 1 20  ? 119.994 89.137  0.686   1.00 56.30  ?  5   LYS   A CE     1 
ATOM   54   N  NZ     . LYS   A 1 20  ? 121.173 89.706  -0.031  1.00 52.97  1  5   LYS   A NZ     1 
ATOM   55   N  N      . PHE   A 1 21  ? 116.249 94.903  1.303   1.00 46.51  ?  6   PHE   A N      1 
ATOM   56   C  CA     . PHE   A 1 21  ? 115.366 95.789  0.542   1.00 45.15  ?  6   PHE   A CA     1 
ATOM   57   C  C      . PHE   A 1 21  ? 114.856 96.989  1.330   1.00 49.92  ?  6   PHE   A C      1 
ATOM   58   O  O      . PHE   A 1 21  ? 113.817 97.526  0.972   1.00 49.57  ?  6   PHE   A O      1 
ATOM   59   C  CB     . PHE   A 1 21  ? 114.167 94.980  0.015   1.00 45.63  ?  6   PHE   A CB     1 
ATOM   60   C  CG     . PHE   A 1 21  ? 114.576 93.842  -0.872  1.00 46.12  ?  6   PHE   A CG     1 
ATOM   61   C  CD1    . PHE   A 1 21  ? 114.985 94.072  -2.177  1.00 48.79  ?  6   PHE   A CD1    1 
ATOM   62   C  CD2    . PHE   A 1 21  ? 114.591 92.539  -0.394  1.00 47.00  ?  6   PHE   A CD2    1 
ATOM   63   C  CE1    . PHE   A 1 21  ? 115.399 93.016  -2.988  1.00 49.62  ?  6   PHE   A CE1    1 
ATOM   64   C  CE2    . PHE   A 1 21  ? 114.981 91.486  -1.213  1.00 49.47  ?  6   PHE   A CE2    1 
ATOM   65   C  CZ     . PHE   A 1 21  ? 115.401 91.731  -2.500  1.00 47.59  ?  6   PHE   A CZ     1 
ATOM   66   N  N      . ALA   A 1 22  ? 115.559 97.406  2.398   1.00 47.14  ?  7   ALA   A N      1 
ATOM   67   C  CA     . ALA   A 1 22  ? 115.133 98.540  3.216   1.00 47.05  ?  7   ALA   A CA     1 
ATOM   68   C  C      . ALA   A 1 22  ? 115.306 99.890  2.521   1.00 51.75  ?  7   ALA   A C      1 
ATOM   69   O  O      . ALA   A 1 22  ? 114.456 100.760 2.691   1.00 52.40  ?  7   ALA   A O      1 
ATOM   70   C  CB     . ALA   A 1 22  ? 115.875 98.540  4.544   1.00 47.69  ?  7   ALA   A CB     1 
ATOM   71   N  N      . LYS   A 1 23  ? 116.408 100.079 1.766   1.00 47.30  ?  8   LYS   A N      1 
ATOM   72   C  CA     . LYS   A 1 23  ? 116.712 101.360 1.124   1.00 45.83  ?  8   LYS   A CA     1 
ATOM   73   C  C      . LYS   A 1 23  ? 115.787 101.741 -0.043  1.00 48.33  ?  8   LYS   A C      1 
ATOM   74   O  O      . LYS   A 1 23  ? 115.437 100.898 -0.867  1.00 44.14  ?  8   LYS   A O      1 
ATOM   75   C  CB     . LYS   A 1 23  ? 118.180 101.422 0.688   1.00 47.79  ?  8   LYS   A CB     1 
ATOM   76   C  CG     . LYS   A 1 23  ? 118.726 102.843 0.583   1.00 56.53  ?  8   LYS   A CG     1 
ATOM   77   C  CD     . LYS   A 1 23  ? 120.096 102.896 -0.092  1.00 55.53  ?  8   LYS   A CD     1 
ATOM   78   C  CE     . LYS   A 1 23  ? 120.462 104.278 -0.581  1.00 49.64  ?  8   LYS   A CE     1 
ATOM   79   N  NZ     . LYS   A 1 23  ? 120.498 105.272 0.525   1.00 54.17  1  8   LYS   A NZ     1 
ATOM   80   N  N      A GLU   A 1 24  ? 115.399 103.032 -0.073  0.54 46.62  ?  9   GLU   A N      1 
ATOM   81   N  N      B GLU   A 1 24  ? 115.378 103.027 -0.085  0.46 45.89  ?  9   GLU   A N      1 
ATOM   82   C  CA     A GLU   A 1 24  ? 114.566 103.691 -1.078  0.54 46.56  ?  9   GLU   A CA     1 
ATOM   83   C  CA     B GLU   A 1 24  ? 114.556 103.622 -1.143  0.46 45.59  ?  9   GLU   A CA     1 
ATOM   84   C  C      A GLU   A 1 24  ? 115.404 104.827 -1.666  0.54 48.04  ?  9   GLU   A C      1 
ATOM   85   C  C      B GLU   A 1 24  ? 115.329 104.832 -1.673  0.46 47.60  ?  9   GLU   A C      1 
ATOM   86   O  O      A GLU   A 1 24  ? 116.009 105.584 -0.905  0.54 47.15  ?  9   GLU   A O      1 
ATOM   87   O  O      B GLU   A 1 24  ? 115.812 105.640 -0.880  0.46 46.66  ?  9   GLU   A O      1 
ATOM   88   C  CB     A GLU   A 1 24  ? 113.315 104.290 -0.415  0.54 48.39  ?  9   GLU   A CB     1 
ATOM   89   C  CB     B GLU   A 1 24  ? 113.171 104.042 -0.624  0.46 47.19  ?  9   GLU   A CB     1 
ATOM   90   C  CG     A GLU   A 1 24  ? 112.046 103.493 -0.636  0.54 61.14  ?  9   GLU   A CG     1 
ATOM   91   C  CG     B GLU   A 1 24  ? 112.181 104.336 -1.739  0.46 56.80  ?  9   GLU   A CG     1 
ATOM   92   C  CD     A GLU   A 1 24  ? 110.843 104.045 0.104   0.54 79.02  ?  9   GLU   A CD     1 
ATOM   93   C  CD     B GLU   A 1 24  ? 111.288 105.537 -1.504  0.46 80.82  ?  9   GLU   A CD     1 
ATOM   94   O  OE1    A GLU   A 1 24  ? 109.937 104.594 -0.564  0.54 77.48  ?  9   GLU   A OE1    1 
ATOM   95   O  OE1    B GLU   A 1 24  ? 111.511 106.578 -2.164  0.46 72.33  ?  9   GLU   A OE1    1 
ATOM   96   O  OE2    A GLU   A 1 24  ? 110.814 103.944 1.352   0.54 69.27  -1 9   GLU   A OE2    1 
ATOM   97   O  OE2    B GLU   A 1 24  ? 110.360 105.439 -0.669  0.46 77.65  -1 9   GLU   A OE2    1 
ATOM   98   N  N      . SER   A 1 25  ? 115.458 104.943 -3.006  1.00 43.35  ?  10  SER   A N      1 
ATOM   99   C  CA     . SER   A 1 25  ? 116.235 105.996 -3.650  1.00 42.43  ?  10  SER   A CA     1 
ATOM   100  C  C      . SER   A 1 25  ? 115.462 106.789 -4.696  1.00 44.75  ?  10  SER   A C      1 
ATOM   101  O  O      . SER   A 1 25  ? 114.465 106.311 -5.248  1.00 44.08  ?  10  SER   A O      1 
ATOM   102  C  CB     . SER   A 1 25  ? 117.532 105.435 -4.224  1.00 44.33  ?  10  SER   A CB     1 
ATOM   103  O  OG     . SER   A 1 25  ? 118.335 104.839 -3.216  1.00 48.56  ?  10  SER   A OG     1 
ATOM   104  N  N      . LEU   A 1 26  ? 115.928 108.017 -4.956  1.00 39.81  ?  11  LEU   A N      1 
ATOM   105  C  CA     . LEU   A 1 26  ? 115.275 108.928 -5.883  1.00 40.02  ?  11  LEU   A CA     1 
ATOM   106  C  C      . LEU   A 1 26  ? 116.147 109.309 -7.064  1.00 43.81  ?  11  LEU   A C      1 
ATOM   107  O  O      . LEU   A 1 26  ? 117.362 109.429 -6.917  1.00 42.50  ?  11  LEU   A O      1 
ATOM   108  C  CB     . LEU   A 1 26  ? 114.846 110.212 -5.148  1.00 39.98  ?  11  LEU   A CB     1 
ATOM   109  C  CG     . LEU   A 1 26  ? 114.004 110.063 -3.894  1.00 44.75  ?  11  LEU   A CG     1 
ATOM   110  C  CD1    . LEU   A 1 26  ? 114.155 111.272 -3.017  1.00 44.01  ?  11  LEU   A CD1    1 
ATOM   111  C  CD2    . LEU   A 1 26  ? 112.524 109.804 -4.225  1.00 49.14  ?  11  LEU   A CD2    1 
ATOM   112  N  N      . THR   A 1 27  ? 115.518 109.547 -8.222  1.00 41.12  ?  12  THR   A N      1 
ATOM   113  C  CA     . THR   A 1 27  ? 116.209 110.042 -9.415  1.00 41.69  ?  12  THR   A CA     1 
ATOM   114  C  C      . THR   A 1 27  ? 115.718 111.482 -9.681  1.00 48.19  ?  12  THR   A C      1 
ATOM   115  O  O      . THR   A 1 27  ? 114.902 111.978 -8.909  1.00 49.72  ?  12  THR   A O      1 
ATOM   116  C  CB     . THR   A 1 27  ? 116.134 109.064 -10.612 1.00 41.83  ?  12  THR   A CB     1 
ATOM   117  O  OG1    . THR   A 1 27  ? 116.916 109.613 -11.680 1.00 44.81  ?  12  THR   A OG1    1 
ATOM   118  C  CG2    . THR   A 1 27  ? 114.713 108.823 -11.115 1.00 36.27  ?  12  THR   A CG2    1 
ATOM   119  N  N      . PHE   A 1 28  ? 116.230 112.152 -10.730 1.00 44.93  ?  13  PHE   A N      1 
ATOM   120  C  CA     . PHE   A 1 28  ? 115.866 113.528 -11.107 1.00 45.25  ?  13  PHE   A CA     1 
ATOM   121  C  C      . PHE   A 1 28  ? 114.378 113.731 -11.381 1.00 47.00  ?  13  PHE   A C      1 
ATOM   122  O  O      . PHE   A 1 28  ? 113.817 114.743 -10.977 1.00 47.85  ?  13  PHE   A O      1 
ATOM   123  C  CB     . PHE   A 1 28  ? 116.687 114.004 -12.323 1.00 47.41  ?  13  PHE   A CB     1 
ATOM   124  C  CG     . PHE   A 1 28  ? 118.183 113.989 -12.126 1.00 48.82  ?  13  PHE   A CG     1 
ATOM   125  C  CD1    . PHE   A 1 28  ? 118.835 115.072 -11.548 1.00 52.89  ?  13  PHE   A CD1    1 
ATOM   126  C  CD2    . PHE   A 1 28  ? 118.941 112.900 -12.531 1.00 51.24  ?  13  PHE   A CD2    1 
ATOM   127  C  CE1    . PHE   A 1 28  ? 120.220 115.058 -11.369 1.00 53.77  ?  13  PHE   A CE1    1 
ATOM   128  C  CE2    . PHE   A 1 28  ? 120.326 112.890 -12.357 1.00 54.13  ?  13  PHE   A CE2    1 
ATOM   129  C  CZ     . PHE   A 1 28  ? 120.954 113.964 -11.774 1.00 52.14  ?  13  PHE   A CZ     1 
ATOM   130  N  N      . ASP   A 1 29  ? 113.755 112.794 -12.081 1.00 42.35  ?  14  ASP   A N      1 
ATOM   131  C  CA     . ASP   A 1 29  ? 112.345 112.850 -12.442 1.00 41.96  ?  14  ASP   A CA     1 
ATOM   132  C  C      . ASP   A 1 29  ? 111.396 112.673 -11.256 1.00 46.05  ?  14  ASP   A C      1 
ATOM   133  O  O      . ASP   A 1 29  ? 110.226 113.017 -11.383 1.00 46.87  ?  14  ASP   A O      1 
ATOM   134  C  CB     . ASP   A 1 29  ? 112.036 111.820 -13.535 1.00 44.35  ?  14  ASP   A CB     1 
ATOM   135  C  CG     . ASP   A 1 29  ? 112.644 112.127 -14.898 1.00 56.77  ?  14  ASP   A CG     1 
ATOM   136  O  OD1    . ASP   A 1 29  ? 113.381 113.137 -15.011 1.00 56.19  ?  14  ASP   A OD1    1 
ATOM   137  O  OD2    . ASP   A 1 29  ? 112.373 111.361 -15.855 1.00 63.14  -1 14  ASP   A OD2    1 
ATOM   138  N  N      . ASP   A 1 30  ? 111.881 112.134 -10.125 1.00 41.66  ?  15  ASP   A N      1 
ATOM   139  C  CA     . ASP   A 1 30  ? 111.073 111.923 -8.920  1.00 41.52  ?  15  ASP   A CA     1 
ATOM   140  C  C      . ASP   A 1 30  ? 110.804 113.200 -8.104  1.00 46.18  ?  15  ASP   A C      1 
ATOM   141  O  O      . ASP   A 1 30  ? 109.845 113.244 -7.325  1.00 44.30  ?  15  ASP   A O      1 
ATOM   142  C  CB     . ASP   A 1 30  ? 111.765 110.908 -8.016  1.00 42.42  ?  15  ASP   A CB     1 
ATOM   143  C  CG     . ASP   A 1 30  ? 111.742 109.491 -8.548  1.00 49.79  ?  15  ASP   A CG     1 
ATOM   144  O  OD1    . ASP   A 1 30  ? 110.666 109.046 -9.026  1.00 51.13  ?  15  ASP   A OD1    1 
ATOM   145  O  OD2    . ASP   A 1 30  ? 112.764 108.798 -8.412  1.00 49.76  -1 15  ASP   A OD2    1 
ATOM   146  N  N      . VAL   A 1 31  ? 111.679 114.213 -8.259  1.00 43.73  ?  16  VAL   A N      1 
ATOM   147  C  CA     . VAL   A 1 31  ? 111.678 115.444 -7.475  1.00 44.11  ?  16  VAL   A CA     1 
ATOM   148  C  C      . VAL   A 1 31  ? 111.588 116.728 -8.300  1.00 50.88  ?  16  VAL   A C      1 
ATOM   149  O  O      . VAL   A 1 31  ? 111.928 116.733 -9.481  1.00 53.00  ?  16  VAL   A O      1 
ATOM   150  C  CB     . VAL   A 1 31  ? 112.923 115.497 -6.529  1.00 47.54  ?  16  VAL   A CB     1 
ATOM   151  C  CG1    . VAL   A 1 31  ? 112.966 114.294 -5.582  1.00 47.32  ?  16  VAL   A CG1    1 
ATOM   152  C  CG2    . VAL   A 1 31  ? 114.236 115.626 -7.315  1.00 47.02  ?  16  VAL   A CG2    1 
ATOM   153  N  N      . LEU   A 1 32  ? 111.190 117.821 -7.636  1.00 45.27  ?  17  LEU   A N      1 
ATOM   154  C  CA     . LEU   A 1 32  ? 111.118 119.197 -8.133  1.00 44.83  ?  17  LEU   A CA     1 
ATOM   155  C  C      . LEU   A 1 32  ? 111.454 120.124 -6.962  1.00 49.65  ?  17  LEU   A C      1 
ATOM   156  O  O      . LEU   A 1 32  ? 111.142 119.789 -5.815  1.00 48.75  ?  17  LEU   A O      1 
ATOM   157  C  CB     . LEU   A 1 32  ? 109.716 119.554 -8.658  1.00 44.05  ?  17  LEU   A CB     1 
ATOM   158  C  CG     . LEU   A 1 32  ? 109.317 119.056 -10.042 1.00 47.20  ?  17  LEU   A CG     1 
ATOM   159  C  CD1    . LEU   A 1 32  ? 107.832 119.248 -10.256 1.00 46.33  ?  17  LEU   A CD1    1 
ATOM   160  C  CD2    . LEU   A 1 32  ? 110.100 119.752 -11.149 1.00 46.68  ?  17  LEU   A CD2    1 
ATOM   161  N  N      . LEU   A 1 33  ? 112.043 121.296 -7.251  1.00 46.41  ?  18  LEU   A N      1 
ATOM   162  C  CA     . LEU   A 1 33  ? 112.398 122.282 -6.230  1.00 46.88  ?  18  LEU   A CA     1 
ATOM   163  C  C      . LEU   A 1 33  ? 111.230 123.164 -5.878  1.00 52.35  ?  18  LEU   A C      1 
ATOM   164  O  O      . LEU   A 1 33  ? 110.480 123.600 -6.755  1.00 51.59  ?  18  LEU   A O      1 
ATOM   165  C  CB     . LEU   A 1 33  ? 113.614 123.120 -6.657  1.00 47.33  ?  18  LEU   A CB     1 
ATOM   166  C  CG     . LEU   A 1 33  ? 114.941 122.389 -6.659  1.00 52.16  ?  18  LEU   A CG     1 
ATOM   167  C  CD1    . LEU   A 1 33  ? 115.924 123.048 -7.605  1.00 52.46  ?  18  LEU   A CD1    1 
ATOM   168  C  CD2    . LEU   A 1 33  ? 115.517 122.293 -5.252  1.00 54.57  ?  18  LEU   A CD2    1 
ATOM   169  N  N      . ILE   A 1 34  ? 111.049 123.389 -4.577  1.00 50.48  ?  19  ILE   A N      1 
ATOM   170  C  CA     . ILE   A 1 34  ? 109.961 124.192 -4.042  1.00 50.22  ?  19  ILE   A CA     1 
ATOM   171  C  C      . ILE   A 1 34  ? 110.311 125.684 -4.172  1.00 55.95  ?  19  ILE   A C      1 
ATOM   172  O  O      . ILE   A 1 34  ? 111.368 126.092 -3.690  1.00 56.49  ?  19  ILE   A O      1 
ATOM   173  C  CB     . ILE   A 1 34  ? 109.629 123.778 -2.579  1.00 52.67  ?  19  ILE   A CB     1 
ATOM   174  C  CG1    . ILE   A 1 34  ? 109.198 122.284 -2.498  1.00 52.30  ?  19  ILE   A CG1    1 
ATOM   175  C  CG2    . ILE   A 1 34  ? 108.549 124.694 -1.979  1.00 53.14  ?  19  ILE   A CG2    1 
ATOM   176  C  CD1    . ILE   A 1 34  ? 109.307 121.619 -1.048  1.00 48.10  ?  19  ILE   A CD1    1 
ATOM   177  N  N      . PRO   A 1 35  ? 109.451 126.508 -4.811  1.00 52.58  ?  20  PRO   A N      1 
ATOM   178  C  CA     . PRO   A 1 35  ? 109.759 127.945 -4.911  1.00 52.80  ?  20  PRO   A CA     1 
ATOM   179  C  C      . PRO   A 1 35  ? 109.686 128.619 -3.535  1.00 58.03  ?  20  PRO   A C      1 
ATOM   180  O  O      . PRO   A 1 35  ? 108.728 128.389 -2.791  1.00 58.22  ?  20  PRO   A O      1 
ATOM   181  C  CB     . PRO   A 1 35  ? 108.688 128.471 -5.868  1.00 54.30  ?  20  PRO   A CB     1 
ATOM   182  C  CG     . PRO   A 1 35  ? 107.547 127.531 -5.720  1.00 58.44  ?  20  PRO   A CG     1 
ATOM   183  C  CD     . PRO   A 1 35  ? 108.150 126.188 -5.434  1.00 53.82  ?  20  PRO   A CD     1 
ATOM   184  N  N      . ALA   A 1 36  ? 110.727 129.389 -3.174  1.00 54.95  ?  21  ALA   A N      1 
ATOM   185  C  CA     . ALA   A 1 36  ? 110.815 130.078 -1.881  1.00 55.05  ?  21  ALA   A CA     1 
ATOM   186  C  C      . ALA   A 1 36  ? 111.020 131.605 -2.026  1.00 61.07  ?  21  ALA   A C      1 
ATOM   187  O  O      . ALA   A 1 36  ? 111.152 132.110 -3.147  1.00 57.91  ?  21  ALA   A O      1 
ATOM   188  C  CB     . ALA   A 1 36  ? 111.925 129.465 -1.038  1.00 55.40  ?  21  ALA   A CB     1 
ATOM   189  N  N      . GLN   A 1 37  ? 111.030 132.327 -0.876  1.00 62.32  ?  22  GLN   A N      1 
ATOM   190  C  CA     . GLN   A 1 37  ? 111.224 133.778 -0.771  1.00 64.04  ?  22  GLN   A CA     1 
ATOM   191  C  C      . GLN   A 1 37  ? 112.449 134.210 -1.572  1.00 70.12  ?  22  GLN   A C      1 
ATOM   192  O  O      . GLN   A 1 37  ? 113.524 133.640 -1.392  1.00 69.72  ?  22  GLN   A O      1 
ATOM   193  C  CB     . GLN   A 1 37  ? 111.353 134.204 0.705   1.00 65.78  ?  22  GLN   A CB     1 
ATOM   194  C  CG     . GLN   A 1 37  ? 110.910 135.651 0.988   1.00 83.66  ?  22  GLN   A CG     1 
ATOM   195  C  CD     . GLN   A 1 37  ? 111.881 136.715 0.518   1.00 103.24 ?  22  GLN   A CD     1 
ATOM   196  O  OE1    . GLN   A 1 37  ? 113.107 136.601 0.672   1.00 99.21  ?  22  GLN   A OE1    1 
ATOM   197  N  NE2    . GLN   A 1 37  ? 111.347 137.782 -0.059  1.00 95.06  ?  22  GLN   A NE2    1 
ATOM   198  N  N      . SER   A 1 38  ? 112.260 135.179 -2.491  1.00 68.79  ?  23  SER   A N      1 
ATOM   199  C  CA     . SER   A 1 38  ? 113.317 135.669 -3.374  1.00 69.80  ?  23  SER   A CA     1 
ATOM   200  C  C      . SER   A 1 38  ? 113.536 137.187 -3.312  1.00 75.99  ?  23  SER   A C      1 
ATOM   201  O  O      . SER   A 1 38  ? 112.586 137.963 -3.434  1.00 75.41  ?  23  SER   A O      1 
ATOM   202  C  CB     . SER   A 1 38  ? 113.047 135.239 -4.811  1.00 73.31  ?  23  SER   A CB     1 
ATOM   203  O  OG     . SER   A 1 38  ? 114.131 135.576 -5.664  1.00 83.36  ?  23  SER   A OG     1 
ATOM   204  N  N      . ASP   A 1 39  ? 114.810 137.589 -3.150  1.00 74.12  ?  24  ASP   A N      1 
ATOM   205  C  CA     . ASP   A 1 39  ? 115.268 138.980 -3.116  1.00 74.78  ?  24  ASP   A CA     1 
ATOM   206  C  C      . ASP   A 1 39  ? 116.113 139.258 -4.364  1.00 78.57  ?  24  ASP   A C      1 
ATOM   207  O  O      . ASP   A 1 39  ? 116.076 140.366 -4.902  1.00 78.32  ?  24  ASP   A O      1 
ATOM   208  C  CB     . ASP   A 1 39  ? 116.123 139.243 -1.855  1.00 77.07  ?  24  ASP   A CB     1 
ATOM   209  C  CG     . ASP   A 1 39  ? 115.393 139.107 -0.533  1.00 89.25  ?  24  ASP   A CG     1 
ATOM   210  O  OD1    . ASP   A 1 39  ? 114.334 139.761 -0.366  1.00 91.18  ?  24  ASP   A OD1    1 
ATOM   211  O  OD2    . ASP   A 1 39  ? 115.909 138.396 0.358   1.00 92.74  -1 24  ASP   A OD2    1 
ATOM   212  N  N      . ILE   A 1 40  ? 116.880 138.246 -4.809  1.00 74.70  ?  25  ILE   A N      1 
ATOM   213  C  CA     . ILE   A 1 40  ? 117.790 138.323 -5.952  1.00 74.39  ?  25  ILE   A CA     1 
ATOM   214  C  C      . ILE   A 1 40  ? 117.117 137.870 -7.267  1.00 78.91  ?  25  ILE   A C      1 
ATOM   215  O  O      . ILE   A 1 40  ? 116.292 136.950 -7.272  1.00 78.47  ?  25  ILE   A O      1 
ATOM   216  C  CB     . ILE   A 1 40  ? 119.116 137.564 -5.634  1.00 77.42  ?  25  ILE   A CB     1 
ATOM   217  C  CG1    . ILE   A 1 40  ? 120.212 137.830 -6.699  1.00 78.03  ?  25  ILE   A CG1    1 
ATOM   218  C  CG2    . ILE   A 1 40  ? 118.890 136.058 -5.397  1.00 77.78  ?  25  ILE   A CG2    1 
ATOM   219  C  CD1    . ILE   A 1 40  ? 121.641 137.832 -6.177  1.00 85.21  ?  25  ILE   A CD1    1 
ATOM   220  N  N      . LEU   A 1 41  ? 117.469 138.555 -8.370  1.00 75.57  ?  26  LEU   A N      1 
ATOM   221  C  CA     . LEU   A 1 41  ? 117.001 138.276 -9.726  1.00 75.05  ?  26  LEU   A CA     1 
ATOM   222  C  C      . LEU   A 1 41  ? 117.898 137.204 -10.362 1.00 77.45  ?  26  LEU   A C      1 
ATOM   223  O  O      . LEU   A 1 41  ? 119.085 137.156 -10.018 1.00 76.76  ?  26  LEU   A O      1 
ATOM   224  C  CB     . LEU   A 1 41  ? 117.043 139.562 -10.571 1.00 75.31  ?  26  LEU   A CB     1 
ATOM   225  C  CG     . LEU   A 1 41  ? 115.848 140.505 -10.431 1.00 80.15  ?  26  LEU   A CG     1 
ATOM   226  C  CD1    . LEU   A 1 41  ? 116.251 141.940 -10.721 1.00 80.23  ?  26  LEU   A CD1    1 
ATOM   227  C  CD2    . LEU   A 1 41  ? 114.693 140.080 -11.338 1.00 82.81  ?  26  LEU   A CD2    1 
ATOM   228  N  N      . PRO   A 1 42  ? 117.370 136.350 -11.288 1.00 73.18  ?  27  PRO   A N      1 
ATOM   229  C  CA     . PRO   A 1 42  ? 118.219 135.321 -11.923 1.00 72.88  ?  27  PRO   A CA     1 
ATOM   230  C  C      . PRO   A 1 42  ? 119.538 135.849 -12.491 1.00 77.38  ?  27  PRO   A C      1 
ATOM   231  O  O      . PRO   A 1 42  ? 120.590 135.277 -12.213 1.00 76.24  ?  27  PRO   A O      1 
ATOM   232  C  CB     . PRO   A 1 42  ? 117.320 134.759 -13.027 1.00 74.43  ?  27  PRO   A CB     1 
ATOM   233  C  CG     . PRO   A 1 42  ? 115.950 134.969 -12.530 1.00 78.93  ?  27  PRO   A CG     1 
ATOM   234  C  CD     . PRO   A 1 42  ? 115.983 136.275 -11.796 1.00 74.52  ?  27  PRO   A CD     1 
ATOM   235  N  N      . LYS   A 1 43  ? 119.483 136.979 -13.225 1.00 75.19  ?  28  LYS   A N      1 
ATOM   236  C  CA     . LYS   A 1 43  ? 120.630 137.649 -13.855 1.00 75.53  ?  28  LYS   A CA     1 
ATOM   237  C  C      . LYS   A 1 43  ? 121.776 138.024 -12.887 1.00 79.97  ?  28  LYS   A C      1 
ATOM   238  O  O      . LYS   A 1 43  ? 122.923 138.139 -13.328 1.00 79.88  ?  28  LYS   A O      1 
ATOM   239  C  CB     . LYS   A 1 43  ? 120.161 138.891 -14.645 1.00 78.09  ?  28  LYS   A CB     1 
ATOM   240  C  CG     . LYS   A 1 43  ? 119.515 139.995 -13.800 1.00 92.04  ?  28  LYS   A CG     1 
ATOM   241  C  CD     . LYS   A 1 43  ? 119.004 141.144 -14.665 1.00 101.44 ?  28  LYS   A CD     1 
ATOM   242  C  CE     . LYS   A 1 43  ? 118.749 142.407 -13.877 1.00 108.91 ?  28  LYS   A CE     1 
ATOM   243  N  NZ     . LYS   A 1 43  ? 120.010 143.130 -13.561 1.00 117.68 1  28  LYS   A NZ     1 
ATOM   244  N  N      . ASP   A 1 44  ? 121.472 138.173 -11.580 1.00 76.78  ?  29  ASP   A N      1 
ATOM   245  C  CA     . ASP   A 1 44  ? 122.436 138.595 -10.561 1.00 77.02  ?  29  ASP   A CA     1 
ATOM   246  C  C      . ASP   A 1 44  ? 122.941 137.497 -9.595  1.00 80.73  ?  29  ASP   A C      1 
ATOM   247  O  O      . ASP   A 1 44  ? 123.857 137.777 -8.814  1.00 80.54  ?  29  ASP   A O      1 
ATOM   248  C  CB     . ASP   A 1 44  ? 121.854 139.771 -9.750  1.00 79.03  ?  29  ASP   A CB     1 
ATOM   249  C  CG     . ASP   A 1 44  ? 121.407 140.966 -10.574 1.00 87.29  ?  29  ASP   A CG     1 
ATOM   250  O  OD1    . ASP   A 1 44  ? 120.365 141.564 -10.230 1.00 87.05  ?  29  ASP   A OD1    1 
ATOM   251  O  OD2    . ASP   A 1 44  ? 122.106 141.310 -11.558 1.00 92.55  -1 29  ASP   A OD2    1 
ATOM   252  N  N      . VAL   A 1 45  ? 122.373 136.269 -9.641  1.00 76.19  ?  30  VAL   A N      1 
ATOM   253  C  CA     . VAL   A 1 45  ? 122.775 135.180 -8.734  1.00 75.38  ?  30  VAL   A CA     1 
ATOM   254  C  C      . VAL   A 1 45  ? 124.240 134.767 -8.955  1.00 78.32  ?  30  VAL   A C      1 
ATOM   255  O  O      . VAL   A 1 45  ? 124.761 134.912 -10.064 1.00 78.00  ?  30  VAL   A O      1 
ATOM   256  C  CB     . VAL   A 1 45  ? 121.812 133.954 -8.720  1.00 79.03  ?  30  VAL   A CB     1 
ATOM   257  C  CG1    . VAL   A 1 45  ? 120.373 134.371 -8.429  1.00 78.68  ?  30  VAL   A CG1    1 
ATOM   258  C  CG2    . VAL   A 1 45  ? 121.895 133.140 -10.006 1.00 78.89  ?  30  VAL   A CG2    1 
ATOM   259  N  N      . ASP   A 1 46  ? 124.902 134.287 -7.891  1.00 74.07  ?  31  ASP   A N      1 
ATOM   260  C  CA     . ASP   A 1 46  ? 126.297 133.867 -7.954  1.00 73.94  ?  31  ASP   A CA     1 
ATOM   261  C  C      . ASP   A 1 46  ? 126.392 132.393 -8.325  1.00 78.45  ?  31  ASP   A C      1 
ATOM   262  O  O      . ASP   A 1 46  ? 125.870 131.541 -7.600  1.00 78.51  ?  31  ASP   A O      1 
ATOM   263  C  CB     . ASP   A 1 46  ? 127.025 134.160 -6.624  1.00 75.73  ?  31  ASP   A CB     1 
ATOM   264  C  CG     . ASP   A 1 46  ? 128.500 133.802 -6.616  1.00 87.40  ?  31  ASP   A CG     1 
ATOM   265  O  OD1    . ASP   A 1 46  ? 129.188 134.082 -7.626  1.00 88.03  ?  31  ASP   A OD1    1 
ATOM   266  O  OD2    . ASP   A 1 46  ? 128.973 133.256 -5.595  1.00 94.59  -1 31  ASP   A OD2    1 
ATOM   267  N  N      . LEU   A 1 47  ? 127.054 132.099 -9.460  1.00 74.61  ?  32  LEU   A N      1 
ATOM   268  C  CA     . LEU   A 1 47  ? 127.238 130.740 -9.976  1.00 74.22  ?  32  LEU   A CA     1 
ATOM   269  C  C      . LEU   A 1 47  ? 128.593 130.147 -9.588  1.00 77.85  ?  32  LEU   A C      1 
ATOM   270  O  O      . LEU   A 1 47  ? 128.826 128.967 -9.836  1.00 76.72  ?  32  LEU   A O      1 
ATOM   271  C  CB     . LEU   A 1 47  ? 127.077 130.703 -11.510 1.00 74.31  ?  32  LEU   A CB     1 
ATOM   272  C  CG     . LEU   A 1 47  ? 125.795 131.265 -12.135 1.00 79.14  ?  32  LEU   A CG     1 
ATOM   273  C  CD1    . LEU   A 1 47  ? 125.961 131.409 -13.629 1.00 79.43  ?  32  LEU   A CD1    1 
ATOM   274  C  CD2    . LEU   A 1 47  ? 124.578 130.389 -11.833 1.00 81.56  ?  32  LEU   A CD2    1 
ATOM   275  N  N      . SER   A 1 48  ? 129.489 130.961 -8.995  1.00 75.51  ?  33  SER   A N      1 
ATOM   276  C  CA     . SER   A 1 48  ? 130.837 130.541 -8.597  1.00 75.33  ?  33  SER   A CA     1 
ATOM   277  C  C      . SER   A 1 48  ? 130.857 129.487 -7.487  1.00 79.37  ?  33  SER   A C      1 
ATOM   278  O  O      . SER   A 1 48  ? 129.960 129.467 -6.643  1.00 78.64  ?  33  SER   A O      1 
ATOM   279  C  CB     . SER   A 1 48  ? 131.695 131.747 -8.223  1.00 78.35  ?  33  SER   A CB     1 
ATOM   280  O  OG     . SER   A 1 48  ? 131.232 132.388 -7.046  1.00 85.33  ?  33  SER   A OG     1 
ATOM   281  N  N      . VAL   A 1 49  ? 131.881 128.607 -7.506  1.00 76.79  ?  34  VAL   A N      1 
ATOM   282  C  CA     . VAL   A 1 49  ? 132.069 127.525 -6.530  1.00 76.96  ?  34  VAL   A CA     1 
ATOM   283  C  C      . VAL   A 1 49  ? 133.564 127.194 -6.323  1.00 81.65  ?  34  VAL   A C      1 
ATOM   284  O  O      . VAL   A 1 49  ? 134.319 127.071 -7.292  1.00 81.04  ?  34  VAL   A O      1 
ATOM   285  C  CB     . VAL   A 1 49  ? 131.210 126.259 -6.851  1.00 80.82  ?  34  VAL   A CB     1 
ATOM   286  C  CG1    . VAL   A 1 49  ? 131.579 125.618 -8.193  1.00 80.35  ?  34  VAL   A CG1    1 
ATOM   287  C  CG2    . VAL   A 1 49  ? 131.248 125.236 -5.714  1.00 80.70  ?  34  VAL   A CG2    1 
ATOM   288  N  N      . GLN   A 1 50  ? 133.967 127.060 -5.045  1.00 78.80  ?  35  GLN   A N      1 
ATOM   289  C  CA     . GLN   A 1 50  ? 135.323 126.718 -4.620  1.00 78.88  ?  35  GLN   A CA     1 
ATOM   290  C  C      . GLN   A 1 50  ? 135.364 125.197 -4.384  1.00 83.40  ?  35  GLN   A C      1 
ATOM   291  O  O      . GLN   A 1 50  ? 134.777 124.703 -3.415  1.00 83.21  ?  35  GLN   A O      1 
ATOM   292  C  CB     . GLN   A 1 50  ? 135.686 127.508 -3.343  1.00 80.26  ?  35  GLN   A CB     1 
ATOM   293  C  CG     . GLN   A 1 50  ? 137.164 127.452 -2.939  1.00 94.09  ?  35  GLN   A CG     1 
ATOM   294  C  CD     . GLN   A 1 50  ? 138.034 128.482 -3.629  1.00 107.85 ?  35  GLN   A CD     1 
ATOM   295  O  OE1    . GLN   A 1 50  ? 137.654 129.644 -3.818  1.00 101.15 ?  35  GLN   A OE1    1 
ATOM   296  N  NE2    . GLN   A 1 50  ? 139.253 128.097 -3.961  1.00 99.80  ?  35  GLN   A NE2    1 
ATOM   297  N  N      . LEU   A 1 51  ? 136.012 124.462 -5.302  1.00 80.12  ?  36  LEU   A N      1 
ATOM   298  C  CA     . LEU   A 1 51  ? 136.122 122.996 -5.262  1.00 80.24  ?  36  LEU   A CA     1 
ATOM   299  C  C      . LEU   A 1 51  ? 137.219 122.525 -4.310  1.00 85.81  ?  36  LEU   A C      1 
ATOM   300  O  O      . LEU   A 1 51  ? 137.035 121.555 -3.574  1.00 84.88  ?  36  LEU   A O      1 
ATOM   301  C  CB     . LEU   A 1 51  ? 136.369 122.428 -6.674  1.00 80.10  ?  36  LEU   A CB     1 
ATOM   302  C  CG     . LEU   A 1 51  ? 135.443 122.896 -7.795  1.00 84.37  ?  36  LEU   A CG     1 
ATOM   303  C  CD1    . LEU   A 1 51  ? 136.071 122.644 -9.141  1.00 84.36  ?  36  LEU   A CD1    1 
ATOM   304  C  CD2    . LEU   A 1 51  ? 134.082 122.230 -7.706  1.00 86.94  ?  36  LEU   A CD2    1 
ATOM   305  N  N      . SER   A 1 52  ? 138.373 123.203 -4.357  1.00 84.23  ?  37  SER   A N      1 
ATOM   306  C  CA     . SER   A 1 52  ? 139.541 122.956 -3.516  1.00 84.69  ?  37  SER   A CA     1 
ATOM   307  C  C      . SER   A 1 52  ? 140.156 124.325 -3.219  1.00 89.63  ?  37  SER   A C      1 
ATOM   308  O  O      . SER   A 1 52  ? 139.605 125.338 -3.669  1.00 89.07  ?  37  SER   A O      1 
ATOM   309  C  CB     . SER   A 1 52  ? 140.533 122.047 -4.239  1.00 88.63  ?  37  SER   A CB     1 
ATOM   310  O  OG     . SER   A 1 52  ? 141.049 122.656 -5.412  1.00 98.26  ?  37  SER   A OG     1 
ATOM   311  N  N      A ASP   A 1 53  ? 141.273 124.365 -2.463  0.47 86.49  ?  38  ASP   A N      1 
ATOM   312  N  N      B ASP   A 1 53  ? 141.272 124.362 -2.465  0.53 86.33  ?  38  ASP   A N      1 
ATOM   313  C  CA     A ASP   A 1 53  ? 141.969 125.610 -2.119  0.47 86.34  ?  38  ASP   A CA     1 
ATOM   314  C  CA     B ASP   A 1 53  ? 141.982 125.599 -2.122  0.53 86.10  ?  38  ASP   A CA     1 
ATOM   315  C  C      A ASP   A 1 53  ? 142.557 126.292 -3.364  0.47 90.12  ?  38  ASP   A C      1 
ATOM   316  C  C      B ASP   A 1 53  ? 142.549 126.289 -3.369  0.53 90.03  ?  38  ASP   A C      1 
ATOM   317  O  O      A ASP   A 1 53  ? 142.554 127.521 -3.442  0.47 89.87  ?  38  ASP   A O      1 
ATOM   318  O  O      B ASP   A 1 53  ? 142.526 127.518 -3.453  0.53 89.79  ?  38  ASP   A O      1 
ATOM   319  C  CB     A ASP   A 1 53  ? 143.064 125.352 -1.066  0.47 88.19  ?  38  ASP   A CB     1 
ATOM   320  C  CB     B ASP   A 1 53  ? 143.097 125.334 -1.087  0.53 87.81  ?  38  ASP   A CB     1 
ATOM   321  C  CG     A ASP   A 1 53  ? 142.544 124.873 0.278   0.47 97.65  ?  38  ASP   A CG     1 
ATOM   322  C  CG     B ASP   A 1 53  ? 143.944 124.089 -1.320  0.53 95.76  ?  38  ASP   A CG     1 
ATOM   323  O  OD1    A ASP   A 1 53  ? 141.887 125.672 0.981   0.47 98.10  ?  38  ASP   A OD1    1 
ATOM   324  O  OD1    B ASP   A 1 53  ? 144.390 123.876 -2.470  0.53 95.90  ?  38  ASP   A OD1    1 
ATOM   325  O  OD2    A ASP   A 1 53  ? 142.833 123.714 0.648   0.47 102.93 -1 38  ASP   A OD2    1 
ATOM   326  O  OD2    B ASP   A 1 53  ? 144.195 123.351 -0.341  0.53 100.84 -1 38  ASP   A OD2    1 
ATOM   327  N  N      . LYS   A 1 54  ? 143.024 125.488 -4.343  1.00 86.35  ?  39  LYS   A N      1 
ATOM   328  C  CA     . LYS   A 1 54  ? 143.619 125.960 -5.603  1.00 85.80  ?  39  LYS   A CA     1 
ATOM   329  C  C      . LYS   A 1 54  ? 142.635 126.124 -6.775  1.00 88.10  ?  39  LYS   A C      1 
ATOM   330  O  O      . LYS   A 1 54  ? 142.906 126.925 -7.672  1.00 87.95  ?  39  LYS   A O      1 
ATOM   331  C  CB     . LYS   A 1 54  ? 144.781 125.038 -6.024  1.00 88.61  ?  39  LYS   A CB     1 
ATOM   332  C  CG     . LYS   A 1 54  ? 146.042 125.190 -5.179  1.00 102.59 ?  39  LYS   A CG     1 
ATOM   333  C  CD     . LYS   A 1 54  ? 147.187 124.346 -5.725  1.00 112.92 ?  39  LYS   A CD     1 
ATOM   334  C  CE     . LYS   A 1 54  ? 148.439 124.457 -4.887  1.00 126.33 ?  39  LYS   A CE     1 
ATOM   335  N  NZ     . LYS   A 1 54  ? 148.360 123.638 -3.647  1.00 135.66 1  39  LYS   A NZ     1 
ATOM   336  N  N      . VAL   A 1 55  ? 141.522 125.359 -6.794  1.00 83.03  ?  40  VAL   A N      1 
ATOM   337  C  CA     . VAL   A 1 55  ? 140.559 125.406 -7.903  1.00 81.97  ?  40  VAL   A CA     1 
ATOM   338  C  C      . VAL   A 1 55  ? 139.236 126.107 -7.511  1.00 84.14  ?  40  VAL   A C      1 
ATOM   339  O  O      . VAL   A 1 55  ? 138.637 125.797 -6.480  1.00 83.71  ?  40  VAL   A O      1 
ATOM   340  C  CB     . VAL   A 1 55  ? 140.322 124.002 -8.541  1.00 85.80  ?  40  VAL   A CB     1 
ATOM   341  C  CG1    . VAL   A 1 55  ? 139.562 124.109 -9.863  1.00 85.64  ?  40  VAL   A CG1    1 
ATOM   342  C  CG2    . VAL   A 1 55  ? 141.638 123.255 -8.755  1.00 85.49  ?  40  VAL   A CG2    1 
ATOM   343  N  N      . LYS   A 1 56  ? 138.802 127.057 -8.355  1.00 79.15  ?  41  LYS   A N      1 
ATOM   344  C  CA     . LYS   A 1 56  ? 137.570 127.829 -8.209  1.00 78.25  ?  41  LYS   A CA     1 
ATOM   345  C  C      . LYS   A 1 56  ? 137.048 128.167 -9.612  1.00 80.60  ?  41  LYS   A C      1 
ATOM   346  O  O      . LYS   A 1 56  ? 137.800 128.696 -10.440 1.00 79.52  ?  41  LYS   A O      1 
ATOM   347  C  CB     . LYS   A 1 56  ? 137.813 129.110 -7.388  1.00 80.59  ?  41  LYS   A CB     1 
ATOM   348  C  CG     . LYS   A 1 56  ? 136.539 129.871 -7.036  1.00 91.07  ?  41  LYS   A CG     1 
ATOM   349  C  CD     . LYS   A 1 56  ? 136.714 131.372 -7.206  1.00 100.13 ?  41  LYS   A CD     1 
ATOM   350  C  CE     . LYS   A 1 56  ? 135.439 132.115 -6.896  1.00 111.99 ?  41  LYS   A CE     1 
ATOM   351  N  NZ     . LYS   A 1 56  ? 135.574 133.571 -7.149  1.00 121.70 1  41  LYS   A NZ     1 
ATOM   352  N  N      . LEU   A 1 57  ? 135.764 127.846 -9.872  1.00 76.00  ?  42  LEU   A N      1 
ATOM   353  C  CA     . LEU   A 1 57  ? 135.109 128.075 -11.162 1.00 75.08  ?  42  LEU   A CA     1 
ATOM   354  C  C      . LEU   A 1 57  ? 134.034 129.160 -11.070 1.00 77.43  ?  42  LEU   A C      1 
ATOM   355  O  O      . LEU   A 1 57  ? 133.488 129.396 -9.991  1.00 77.02  ?  42  LEU   A O      1 
ATOM   356  C  CB     . LEU   A 1 57  ? 134.500 126.770 -11.713 1.00 75.17  ?  42  LEU   A CB     1 
ATOM   357  C  CG     . LEU   A 1 57  ? 135.384 125.508 -11.771 1.00 79.96  ?  42  LEU   A CG     1 
ATOM   358  C  CD1    . LEU   A 1 57  ? 134.560 124.298 -12.171 1.00 80.24  ?  42  LEU   A CD1    1 
ATOM   359  C  CD2    . LEU   A 1 57  ? 136.547 125.671 -12.737 1.00 82.36  ?  42  LEU   A CD2    1 
ATOM   360  N  N      . ASN   A 1 58  ? 133.735 129.814 -12.206 1.00 72.67  ?  43  ASN   A N      1 
ATOM   361  C  CA     . ASN   A 1 58  ? 132.734 130.883 -12.319 1.00 71.92  ?  43  ASN   A CA     1 
ATOM   362  C  C      . ASN   A 1 58  ? 131.324 130.328 -12.571 1.00 73.28  ?  43  ASN   A C      1 
ATOM   363  O  O      . ASN   A 1 58  ? 130.336 131.010 -12.277 1.00 72.94  ?  43  ASN   A O      1 
ATOM   364  C  CB     . ASN   A 1 58  ? 133.133 131.898 -13.400 1.00 74.23  ?  43  ASN   A CB     1 
ATOM   365  C  CG     . ASN   A 1 58  ? 134.443 132.619 -13.150 1.00 103.31 ?  43  ASN   A CG     1 
ATOM   366  O  OD1    . ASN   A 1 58  ? 134.724 133.110 -12.047 1.00 99.24  ?  43  ASN   A OD1    1 
ATOM   367  N  ND2    . ASN   A 1 58  ? 135.259 132.740 -14.189 1.00 95.72  ?  43  ASN   A ND2    1 
ATOM   368  N  N      . ILE   A 1 59  ? 131.247 129.113 -13.153 1.00 67.17  ?  44  ILE   A N      1 
ATOM   369  C  CA     . ILE   A 1 59  ? 130.029 128.338 -13.421 1.00 65.76  ?  44  ILE   A CA     1 
ATOM   370  C  C      . ILE   A 1 59  ? 130.260 126.917 -12.862 1.00 68.73  ?  44  ILE   A C      1 
ATOM   371  O  O      . ILE   A 1 59  ? 131.384 126.412 -12.975 1.00 67.40  ?  44  ILE   A O      1 
ATOM   372  C  CB     . ILE   A 1 59  ? 129.532 128.352 -14.900 1.00 68.40  ?  44  ILE   A CB     1 
ATOM   373  C  CG1    . ILE   A 1 59  ? 130.574 127.773 -15.882 1.00 68.58  ?  44  ILE   A CG1    1 
ATOM   374  C  CG2    . ILE   A 1 59  ? 129.059 129.750 -15.323 1.00 68.92  ?  44  ILE   A CG2    1 
ATOM   375  C  CD1    . ILE   A 1 59  ? 130.010 127.049 -17.077 1.00 73.38  ?  44  ILE   A CD1    1 
ATOM   376  N  N      . PRO   A 1 60  ? 129.260 126.270 -12.205 1.00 64.74  ?  45  PRO   A N      1 
ATOM   377  C  CA     . PRO   A 1 60  ? 129.515 124.939 -11.620 1.00 64.05  ?  45  PRO   A CA     1 
ATOM   378  C  C      . PRO   A 1 60  ? 129.396 123.795 -12.623 1.00 65.96  ?  45  PRO   A C      1 
ATOM   379  O  O      . PRO   A 1 60  ? 128.742 122.801 -12.328 1.00 65.76  ?  45  PRO   A O      1 
ATOM   380  C  CB     . PRO   A 1 60  ? 128.455 124.845 -10.528 1.00 66.04  ?  45  PRO   A CB     1 
ATOM   381  C  CG     . PRO   A 1 60  ? 127.304 125.639 -11.065 1.00 70.42  ?  45  PRO   A CG     1 
ATOM   382  C  CD     . PRO   A 1 60  ? 127.867 126.705 -11.964 1.00 65.94  ?  45  PRO   A CD     1 
ATOM   383  N  N      . VAL   A 1 61  ? 130.022 123.936 -13.806 1.00 60.77  ?  46  VAL   A N      1 
ATOM   384  C  CA     . VAL   A 1 61  ? 129.955 122.939 -14.875 1.00 59.55  ?  46  VAL   A CA     1 
ATOM   385  C  C      . VAL   A 1 61  ? 131.354 122.484 -15.257 1.00 62.90  ?  46  VAL   A C      1 
ATOM   386  O  O      . VAL   A 1 61  ? 132.233 123.308 -15.530 1.00 62.52  ?  46  VAL   A O      1 
ATOM   387  C  CB     . VAL   A 1 61  ? 129.185 123.462 -16.124 1.00 63.06  ?  46  VAL   A CB     1 
ATOM   388  C  CG1    . VAL   A 1 61  ? 128.956 122.358 -17.150 1.00 62.89  ?  46  VAL   A CG1    1 
ATOM   389  C  CG2    . VAL   A 1 61  ? 127.867 124.116 -15.744 1.00 62.84  ?  46  VAL   A CG2    1 
ATOM   390  N  N      . ILE   A 1 62  ? 131.538 121.164 -15.298 1.00 58.22  ?  47  ILE   A N      1 
ATOM   391  C  CA     . ILE   A 1 62  ? 132.770 120.502 -15.701 1.00 57.57  ?  47  ILE   A CA     1 
ATOM   392  C  C      . ILE   A 1 62  ? 132.400 119.576 -16.865 1.00 61.09  ?  47  ILE   A C      1 
ATOM   393  O  O      . ILE   A 1 62  ? 131.375 118.890 -16.787 1.00 59.87  ?  47  ILE   A O      1 
ATOM   394  C  CB     . ILE   A 1 62  ? 133.447 119.721 -14.525 1.00 60.23  ?  47  ILE   A CB     1 
ATOM   395  C  CG1    . ILE   A 1 62  ? 133.584 120.589 -13.250 1.00 60.42  ?  47  ILE   A CG1    1 
ATOM   396  C  CG2    . ILE   A 1 62  ? 134.812 119.159 -14.950 1.00 60.47  ?  47  ILE   A CG2    1 
ATOM   397  C  CD1    . ILE   A 1 62  ? 133.770 119.812 -11.953 1.00 60.36  ?  47  ILE   A CD1    1 
ATOM   398  N  N      . SER   A 1 63  ? 133.207 119.573 -17.950 1.00 57.58  ?  48  SER   A N      1 
ATOM   399  C  CA     . SER   A 1 63  ? 132.958 118.671 -19.072 1.00 57.43  ?  48  SER   A CA     1 
ATOM   400  C  C      . SER   A 1 63  ? 133.583 117.302 -18.753 1.00 60.79  ?  48  SER   A C      1 
ATOM   401  O  O      . SER   A 1 63  ? 134.564 117.226 -18.014 1.00 59.68  ?  48  SER   A O      1 
ATOM   402  C  CB     . SER   A 1 63  ? 133.435 119.259 -20.397 1.00 60.94  ?  48  SER   A CB     1 
ATOM   403  O  OG     . SER   A 1 63  ? 134.847 119.281 -20.519 1.00 69.59  ?  48  SER   A OG     1 
ATOM   404  N  N      . ALA   A 1 64  ? 132.958 116.228 -19.245 1.00 58.48  ?  49  ALA   A N      1 
ATOM   405  C  CA     . ALA   A 1 64  ? 133.325 114.837 -18.961 1.00 58.68  ?  49  ALA   A CA     1 
ATOM   406  C  C      . ALA   A 1 64  ? 134.656 114.365 -19.554 1.00 63.31  ?  49  ALA   A C      1 
ATOM   407  O  O      . ALA   A 1 64  ? 135.024 114.766 -20.657 1.00 62.69  ?  49  ALA   A O      1 
ATOM   408  C  CB     . ALA   A 1 64  ? 132.203 113.915 -19.402 1.00 59.18  ?  49  ALA   A CB     1 
ATOM   409  N  N      . GLY   A 1 65  ? 135.333 113.474 -18.825 1.00 59.95  ?  50  GLY   A N      1 
ATOM   410  C  CA     . GLY   A 1 65  ? 136.588 112.861 -19.237 1.00 59.50  ?  50  GLY   A CA     1 
ATOM   411  C  C      . GLY   A 1 65  ? 136.340 111.764 -20.245 1.00 64.19  ?  50  GLY   A C      1 
ATOM   412  O  O      . GLY   A 1 65  ? 136.667 110.598 -20.001 1.00 64.31  ?  50  GLY   A O      1 
ATOM   413  N  N      . MET   A 1 66  ? 135.739 112.144 -21.385 1.00 61.04  ?  51  MET   A N      1 
ATOM   414  C  CA     . MET   A 1 66  ? 135.330 111.240 -22.456 1.00 60.78  ?  51  MET   A CA     1 
ATOM   415  C  C      . MET   A 1 66  ? 135.944 111.596 -23.819 1.00 66.55  ?  51  MET   A C      1 
ATOM   416  O  O      . MET   A 1 66  ? 136.235 112.768 -24.075 1.00 65.32  ?  51  MET   A O      1 
ATOM   417  C  CB     . MET   A 1 66  ? 133.798 111.212 -22.539 1.00 62.63  ?  51  MET   A CB     1 
ATOM   418  C  CG     . MET   A 1 66  ? 133.124 110.727 -21.263 1.00 65.07  ?  51  MET   A CG     1 
ATOM   419  S  SD     . MET   A 1 66  ? 131.326 110.823 -21.311 1.00 67.45  ?  51  MET   A SD     1 
ATOM   420  C  CE     . MET   A 1 66  ? 130.960 109.341 -22.171 1.00 63.70  ?  51  MET   A CE     1 
ATOM   421  N  N      . ASP   A 1 67  ? 136.127 110.565 -24.690 1.00 65.59  ?  52  ASP   A N      1 
ATOM   422  C  CA     . ASP   A 1 67  ? 136.722 110.668 -26.030 1.00 66.15  ?  52  ASP   A CA     1 
ATOM   423  C  C      . ASP   A 1 67  ? 135.784 111.275 -27.091 1.00 71.15  ?  52  ASP   A C      1 
ATOM   424  O  O      . ASP   A 1 67  ? 136.223 111.538 -28.213 1.00 70.88  ?  52  ASP   A O      1 
ATOM   425  C  CB     . ASP   A 1 67  ? 137.304 109.314 -26.510 1.00 68.01  ?  52  ASP   A CB     1 
ATOM   426  C  CG     . ASP   A 1 67  ? 136.360 108.131 -26.660 1.00 79.27  ?  52  ASP   A CG     1 
ATOM   427  O  OD1    . ASP   A 1 67  ? 135.128 108.346 -26.709 1.00 79.04  ?  52  ASP   A OD1    1 
ATOM   428  O  OD2    . ASP   A 1 67  ? 136.859 106.991 -26.785 1.00 87.09  -1 52  ASP   A OD2    1 
ATOM   429  N  N      . THR   A 1 68  ? 134.503 111.479 -26.744 1.00 67.98  ?  53  THR   A N      1 
ATOM   430  C  CA     . THR   A 1 68  ? 133.515 112.112 -27.623 1.00 67.52  ?  53  THR   A CA     1 
ATOM   431  C  C      . THR   A 1 68  ? 133.027 113.416 -26.969 1.00 71.25  ?  53  THR   A C      1 
ATOM   432  O  O      . THR   A 1 68  ? 132.044 114.016 -27.420 1.00 70.79  ?  53  THR   A O      1 
ATOM   433  C  CB     . THR   A 1 68  ? 132.383 111.132 -27.999 1.00 75.96  ?  53  THR   A CB     1 
ATOM   434  O  OG1    . THR   A 1 68  ? 131.813 110.570 -26.818 1.00 77.93  ?  53  THR   A OG1    1 
ATOM   435  C  CG2    . THR   A 1 68  ? 132.847 110.023 -28.936 1.00 72.89  ?  53  THR   A CG2    1 
ATOM   436  N  N      . VAL   A 1 69  ? 133.733 113.855 -25.900 1.00 67.76  ?  54  VAL   A N      1 
ATOM   437  C  CA     . VAL   A 1 69  ? 133.391 115.052 -25.132 1.00 67.81  ?  54  VAL   A CA     1 
ATOM   438  C  C      . VAL   A 1 69  ? 134.576 116.028 -24.964 1.00 72.23  ?  54  VAL   A C      1 
ATOM   439  O  O      . VAL   A 1 69  ? 134.451 117.177 -25.392 1.00 71.87  ?  54  VAL   A O      1 
ATOM   440  C  CB     . VAL   A 1 69  ? 132.724 114.719 -23.750 1.00 71.46  ?  54  VAL   A CB     1 
ATOM   441  C  CG1    . VAL   A 1 69  ? 132.410 115.987 -22.953 1.00 71.13  ?  54  VAL   A CG1    1 
ATOM   442  C  CG2    . VAL   A 1 69  ? 131.462 113.885 -23.917 1.00 71.11  ?  54  VAL   A CG2    1 
ATOM   443  N  N      . THR   A 1 70  ? 135.684 115.617 -24.304 1.00 69.09  ?  55  THR   A N      1 
ATOM   444  C  CA     . THR   A 1 70  ? 136.751 116.584 -24.011 1.00 69.30  ?  55  THR   A CA     1 
ATOM   445  C  C      . THR   A 1 70  ? 138.175 116.245 -24.478 1.00 73.42  ?  55  THR   A C      1 
ATOM   446  O  O      . THR   A 1 70  ? 138.746 115.211 -24.129 1.00 72.61  ?  55  THR   A O      1 
ATOM   447  C  CB     . THR   A 1 70  ? 136.788 116.890 -22.498 1.00 76.53  ?  55  THR   A CB     1 
ATOM   448  O  OG1    . THR   A 1 70  ? 135.465 117.134 -22.032 1.00 78.26  ?  55  THR   A OG1    1 
ATOM   449  C  CG2    . THR   A 1 70  ? 137.683 118.084 -22.140 1.00 74.26  ?  55  THR   A CG2    1 
ATOM   450  N  N      . GLU   A 1 71  ? 138.747 117.220 -25.205 1.00 70.41  ?  56  GLU   A N      1 
ATOM   451  C  CA     . GLU   A 1 71  ? 140.125 117.373 -25.667 1.00 69.91  ?  56  GLU   A CA     1 
ATOM   452  C  C      . GLU   A 1 71  ? 140.434 118.867 -25.422 1.00 72.79  ?  56  GLU   A C      1 
ATOM   453  O  O      . GLU   A 1 71  ? 139.600 119.534 -24.793 1.00 72.28  ?  56  GLU   A O      1 
ATOM   454  C  CB     . GLU   A 1 71  ? 140.294 116.945 -27.133 1.00 71.25  ?  56  GLU   A CB     1 
ATOM   455  C  CG     . GLU   A 1 71  ? 140.571 115.457 -27.262 1.00 81.24  ?  56  GLU   A CG     1 
ATOM   456  C  CD     . GLU   A 1 71  ? 140.885 114.928 -28.647 1.00 103.78 ?  56  GLU   A CD     1 
ATOM   457  O  OE1    . GLU   A 1 71  ? 141.644 115.591 -29.392 1.00 96.48  ?  56  GLU   A OE1    1 
ATOM   458  O  OE2    . GLU   A 1 71  ? 140.419 113.810 -28.963 1.00 100.48 -1 56  GLU   A OE2    1 
ATOM   459  N  N      . SER   A 1 72  ? 141.613 119.388 -25.848 1.00 68.14  ?  57  SER   A N      1 
ATOM   460  C  CA     . SER   A 1 72  ? 142.001 120.788 -25.598 1.00 67.52  ?  57  SER   A CA     1 
ATOM   461  C  C      . SER   A 1 72  ? 140.960 121.825 -26.032 1.00 69.64  ?  57  SER   A C      1 
ATOM   462  O  O      . SER   A 1 72  ? 140.750 122.788 -25.297 1.00 68.91  ?  57  SER   A O      1 
ATOM   463  C  CB     . SER   A 1 72  ? 143.368 121.114 -26.202 1.00 72.14  ?  57  SER   A CB     1 
ATOM   464  O  OG     . SER   A 1 72  ? 143.463 120.781 -27.578 1.00 82.26  ?  57  SER   A OG     1 
ATOM   465  N  N      . LYS   A 1 73  ? 140.293 121.618 -27.191 1.00 65.77  ?  58  LYS   A N      1 
ATOM   466  C  CA     . LYS   A 1 73  ? 139.259 122.509 -27.740 1.00 65.70  ?  58  LYS   A CA     1 
ATOM   467  C  C      . LYS   A 1 73  ? 138.082 122.711 -26.757 1.00 69.46  ?  58  LYS   A C      1 
ATOM   468  O  O      . LYS   A 1 73  ? 137.679 123.851 -26.509 1.00 68.80  ?  58  LYS   A O      1 
ATOM   469  C  CB     . LYS   A 1 73  ? 138.767 121.982 -29.106 1.00 68.32  ?  58  LYS   A CB     1 
ATOM   470  C  CG     . LYS   A 1 73  ? 138.020 123.005 -29.964 1.00 75.73  ?  58  LYS   A CG     1 
ATOM   471  C  CD     . LYS   A 1 73  ? 137.593 122.400 -31.302 1.00 81.04  ?  58  LYS   A CD     1 
ATOM   472  C  CE     . LYS   A 1 73  ? 136.701 123.329 -32.092 1.00 85.31  ?  58  LYS   A CE     1 
ATOM   473  N  NZ     . LYS   A 1 73  ? 136.142 122.674 -33.303 1.00 88.77  1  58  LYS   A NZ     1 
ATOM   474  N  N      . MET   A 1 74  ? 137.557 121.603 -26.190 1.00 66.00  ?  59  MET   A N      1 
ATOM   475  C  CA     . MET   A 1 74  ? 136.469 121.615 -25.207 1.00 65.40  ?  59  MET   A CA     1 
ATOM   476  C  C      . MET   A 1 74  ? 136.907 122.341 -23.940 1.00 70.12  ?  59  MET   A C      1 
ATOM   477  O  O      . MET   A 1 74  ? 136.236 123.289 -23.529 1.00 69.87  ?  59  MET   A O      1 
ATOM   478  C  CB     . MET   A 1 74  ? 136.024 120.178 -24.877 1.00 67.47  ?  59  MET   A CB     1 
ATOM   479  C  CG     . MET   A 1 74  ? 134.921 120.077 -23.820 1.00 70.52  ?  59  MET   A CG     1 
ATOM   480  S  SD     . MET   A 1 74  ? 133.407 121.001 -24.178 1.00 73.59  ?  59  MET   A SD     1 
ATOM   481  C  CE     . MET   A 1 74  ? 132.835 120.158 -25.660 1.00 70.07  ?  59  MET   A CE     1 
ATOM   482  N  N      . ALA   A 1 75  ? 138.048 121.913 -23.348 1.00 67.28  ?  60  ALA   A N      1 
ATOM   483  C  CA     . ALA   A 1 75  ? 138.627 122.478 -22.127 1.00 67.35  ?  60  ALA   A CA     1 
ATOM   484  C  C      . ALA   A 1 75  ? 138.853 123.986 -22.211 1.00 72.64  ?  60  ALA   A C      1 
ATOM   485  O  O      . ALA   A 1 75  ? 138.544 124.691 -21.251 1.00 72.32  ?  60  ALA   A O      1 
ATOM   486  C  CB     . ALA   A 1 75  ? 139.922 121.760 -21.777 1.00 68.06  ?  60  ALA   A CB     1 
ATOM   487  N  N      . ILE   A 1 76  ? 139.352 124.479 -23.368 1.00 70.08  ?  61  ILE   A N      1 
ATOM   488  C  CA     . ILE   A 1 76  ? 139.601 125.897 -23.627 1.00 70.12  ?  61  ILE   A CA     1 
ATOM   489  C  C      . ILE   A 1 76  ? 138.275 126.659 -23.612 1.00 74.71  ?  61  ILE   A C      1 
ATOM   490  O  O      . ILE   A 1 76  ? 138.163 127.646 -22.883 1.00 75.08  ?  61  ILE   A O      1 
ATOM   491  C  CB     . ILE   A 1 76  ? 140.441 126.094 -24.934 1.00 73.51  ?  61  ILE   A CB     1 
ATOM   492  C  CG1    . ILE   A 1 76  ? 141.945 125.845 -24.668 1.00 74.04  ?  61  ILE   A CG1    1 
ATOM   493  C  CG2    . ILE   A 1 76  ? 140.226 127.466 -25.582 1.00 74.22  ?  61  ILE   A CG2    1 
ATOM   494  C  CD1    . ILE   A 1 76  ? 142.755 125.330 -25.876 1.00 80.42  ?  61  ILE   A CD1    1 
ATOM   495  N  N      . ALA   A 1 77  ? 137.265 126.175 -24.376 1.00 71.16  ?  62  ALA   A N      1 
ATOM   496  C  CA     . ALA   A 1 77  ? 135.933 126.794 -24.457 1.00 70.65  ?  62  ALA   A CA     1 
ATOM   497  C  C      . ALA   A 1 77  ? 135.201 126.767 -23.113 1.00 73.53  ?  62  ALA   A C      1 
ATOM   498  O  O      . ALA   A 1 77  ? 134.548 127.755 -22.761 1.00 73.01  ?  62  ALA   A O      1 
ATOM   499  C  CB     . ALA   A 1 77  ? 135.099 126.120 -25.531 1.00 71.34  ?  62  ALA   A CB     1 
ATOM   500  N  N      . MET   A 1 78  ? 135.345 125.649 -22.355 1.00 69.60  ?  63  MET   A N      1 
ATOM   501  C  CA     . MET   A 1 78  ? 134.771 125.450 -21.020 1.00 68.98  ?  63  MET   A CA     1 
ATOM   502  C  C      . MET   A 1 78  ? 135.391 126.443 -20.041 1.00 72.59  ?  63  MET   A C      1 
ATOM   503  O  O      . MET   A 1 78  ? 134.655 127.180 -19.381 1.00 71.53  ?  63  MET   A O      1 
ATOM   504  C  CB     . MET   A 1 78  ? 135.000 124.011 -20.521 1.00 71.12  ?  63  MET   A CB     1 
ATOM   505  C  CG     . MET   A 1 78  ? 133.964 123.009 -21.006 1.00 74.66  ?  63  MET   A CG     1 
ATOM   506  S  SD     . MET   A 1 78  ? 132.232 123.365 -20.577 1.00 78.63  ?  63  MET   A SD     1 
ATOM   507  C  CE     . MET   A 1 78  ? 132.322 123.407 -18.811 1.00 75.19  ?  63  MET   A CE     1 
ATOM   508  N  N      . ALA   A 1 79  ? 136.744 126.498 -19.990 1.00 70.03  ?  64  ALA   A N      1 
ATOM   509  C  CA     . ALA   A 1 79  ? 137.500 127.409 -19.125 1.00 70.73  ?  64  ALA   A CA     1 
ATOM   510  C  C      . ALA   A 1 79  ? 137.209 128.887 -19.407 1.00 77.13  ?  64  ALA   A C      1 
ATOM   511  O  O      . ALA   A 1 79  ? 137.159 129.675 -18.461 1.00 77.07  ?  64  ALA   A O      1 
ATOM   512  C  CB     . ALA   A 1 79  ? 138.984 127.125 -19.223 1.00 71.38  ?  64  ALA   A CB     1 
ATOM   513  N  N      . ARG   A 1 80  ? 136.967 129.252 -20.690 1.00 75.26  ?  65  ARG   A N      1 
ATOM   514  C  CA     . ARG   A 1 80  ? 136.626 130.626 -21.097 1.00 76.08  ?  65  ARG   A CA     1 
ATOM   515  C  C      . ARG   A 1 80  ? 135.243 131.045 -20.584 1.00 80.89  ?  65  ARG   A C      1 
ATOM   516  O  O      . ARG   A 1 80  ? 135.068 132.195 -20.176 1.00 80.87  ?  65  ARG   A O      1 
ATOM   517  C  CB     . ARG   A 1 80  ? 136.707 130.801 -22.625 1.00 77.56  ?  65  ARG   A CB     1 
ATOM   518  C  CG     . ARG   A 1 80  ? 138.126 131.013 -23.140 1.00 90.47  ?  65  ARG   A CG     1 
ATOM   519  C  CD     . ARG   A 1 80  ? 138.154 131.200 -24.644 1.00 100.79 ?  65  ARG   A CD     1 
ATOM   520  N  NE     . ARG   A 1 80  ? 139.467 130.878 -25.203 1.00 108.62 ?  65  ARG   A NE     1 
ATOM   521  C  CZ     . ARG   A 1 80  ? 139.760 130.910 -26.500 1.00 122.86 ?  65  ARG   A CZ     1 
ATOM   522  N  NH1    . ARG   A 1 80  ? 138.836 131.256 -27.388 1.00 110.15 1  65  ARG   A NH1    1 
ATOM   523  N  NH2    . ARG   A 1 80  ? 140.977 130.591 -26.919 1.00 111.09 ?  65  ARG   A NH2    1 
ATOM   524  N  N      . GLN   A 1 81  ? 134.273 130.102 -20.579 1.00 77.39  ?  66  GLN   A N      1 
ATOM   525  C  CA     . GLN   A 1 81  ? 132.904 130.338 -20.096 1.00 76.67  ?  66  GLN   A CA     1 
ATOM   526  C  C      . GLN   A 1 81  ? 132.801 130.328 -18.555 1.00 78.58  ?  66  GLN   A C      1 
ATOM   527  O  O      . GLN   A 1 81  ? 131.744 130.641 -18.003 1.00 77.69  ?  66  GLN   A O      1 
ATOM   528  C  CB     . GLN   A 1 81  ? 131.921 129.343 -20.738 1.00 78.19  ?  66  GLN   A CB     1 
ATOM   529  C  CG     . GLN   A 1 81  ? 131.572 129.671 -22.191 1.00 96.72  ?  66  GLN   A CG     1 
ATOM   530  C  CD     . GLN   A 1 81  ? 130.516 130.742 -22.311 1.00 121.18 ?  66  GLN   A CD     1 
ATOM   531  O  OE1    . GLN   A 1 81  ? 130.819 131.930 -22.467 1.00 118.76 ?  66  GLN   A OE1    1 
ATOM   532  N  NE2    . GLN   A 1 81  ? 129.252 130.346 -22.253 1.00 113.08 ?  66  GLN   A NE2    1 
ATOM   533  N  N      . GLY   A 1 82  ? 133.906 129.991 -17.892 1.00 74.22  ?  67  GLY   A N      1 
ATOM   534  C  CA     . GLY   A 1 82  ? 134.010 129.958 -16.439 1.00 73.75  ?  67  GLY   A CA     1 
ATOM   535  C  C      . GLY   A 1 82  ? 133.926 128.576 -15.825 1.00 77.03  ?  67  GLY   A C      1 
ATOM   536  O  O      . GLY   A 1 82  ? 133.672 128.453 -14.626 1.00 76.83  ?  67  GLY   A O      1 
ATOM   537  N  N      . GLY   A 1 83  ? 134.125 127.546 -16.644 1.00 72.65  ?  68  GLY   A N      1 
ATOM   538  C  CA     . GLY   A 1 83  ? 134.068 126.155 -16.218 1.00 71.93  ?  68  GLY   A CA     1 
ATOM   539  C  C      . GLY   A 1 83  ? 135.401 125.437 -16.271 1.00 75.19  ?  68  GLY   A C      1 
ATOM   540  O  O      . GLY   A 1 83  ? 136.459 126.063 -16.155 1.00 75.49  ?  68  GLY   A O      1 
ATOM   541  N  N      . LEU   A 1 84  ? 135.348 124.109 -16.440 1.00 70.06  ?  69  LEU   A N      1 
ATOM   542  C  CA     . LEU   A 1 84  ? 136.514 123.228 -16.492 1.00 69.20  ?  69  LEU   A CA     1 
ATOM   543  C  C      . LEU   A 1 84  ? 136.285 122.078 -17.475 1.00 72.15  ?  69  LEU   A C      1 
ATOM   544  O  O      . LEU   A 1 84  ? 135.140 121.723 -17.764 1.00 71.61  ?  69  LEU   A O      1 
ATOM   545  C  CB     . LEU   A 1 84  ? 136.797 122.668 -15.076 1.00 69.01  ?  69  LEU   A CB     1 
ATOM   546  C  CG     . LEU   A 1 84  ? 138.101 121.884 -14.856 1.00 73.47  ?  69  LEU   A CG     1 
ATOM   547  C  CD1    . LEU   A 1 84  ? 139.295 122.817 -14.728 1.00 73.44  ?  69  LEU   A CD1    1 
ATOM   548  C  CD2    . LEU   A 1 84  ? 138.001 121.001 -13.629 1.00 75.98  ?  69  LEU   A CD2    1 
ATOM   549  N  N      . GLY   A 1 85  ? 137.384 121.506 -17.956 1.00 68.31  ?  70  GLY   A N      1 
ATOM   550  C  CA     . GLY   A 1 85  ? 137.395 120.360 -18.858 1.00 67.84  ?  70  GLY   A CA     1 
ATOM   551  C  C      . GLY   A 1 85  ? 138.372 119.290 -18.416 1.00 70.41  ?  70  GLY   A C      1 
ATOM   552  O  O      . GLY   A 1 85  ? 139.509 119.601 -18.054 1.00 70.38  ?  70  GLY   A O      1 
ATOM   553  N  N      . VAL   A 1 86  ? 137.934 118.024 -18.445 1.00 66.52  ?  71  VAL   A N      1 
ATOM   554  C  CA     . VAL   A 1 86  ? 138.748 116.868 -18.063 1.00 66.17  ?  71  VAL   A CA     1 
ATOM   555  C  C      . VAL   A 1 86  ? 139.194 116.145 -19.342 1.00 69.87  ?  71  VAL   A C      1 
ATOM   556  O  O      . VAL   A 1 86  ? 138.358 115.522 -19.999 1.00 68.53  ?  71  VAL   A O      1 
ATOM   557  C  CB     . VAL   A 1 86  ? 137.995 115.905 -17.091 1.00 70.19  ?  71  VAL   A CB     1 
ATOM   558  C  CG1    . VAL   A 1 86  ? 138.902 114.763 -16.625 1.00 70.00  ?  71  VAL   A CG1    1 
ATOM   559  C  CG2    . VAL   A 1 86  ? 137.413 116.652 -15.892 1.00 69.83  ?  71  VAL   A CG2    1 
ATOM   560  N  N      . ILE   A 1 87  ? 140.503 116.220 -19.691 1.00 67.18  ?  72  ILE   A N      1 
ATOM   561  C  CA     . ILE   A 1 87  ? 141.040 115.546 -20.883 1.00 67.49  ?  72  ILE   A CA     1 
ATOM   562  C  C      . ILE   A 1 87  ? 141.048 114.040 -20.619 1.00 74.12  ?  72  ILE   A C      1 
ATOM   563  O  O      . ILE   A 1 87  ? 141.589 113.595 -19.606 1.00 73.79  ?  72  ILE   A O      1 
ATOM   564  C  CB     . ILE   A 1 87  ? 142.444 116.060 -21.354 1.00 70.19  ?  72  ILE   A CB     1 
ATOM   565  C  CG1    . ILE   A 1 87  ? 142.614 117.609 -21.212 1.00 70.51  ?  72  ILE   A CG1    1 
ATOM   566  C  CG2    . ILE   A 1 87  ? 142.773 115.577 -22.783 1.00 69.92  ?  72  ILE   A CG2    1 
ATOM   567  C  CD1    . ILE   A 1 87  ? 141.824 118.522 -22.161 1.00 76.16  ?  72  ILE   A CD1    1 
ATOM   568  N  N      . HIS   A 1 88  ? 140.419 113.270 -21.519 1.00 72.85  ?  73  HIS   A N      1 
ATOM   569  C  CA     . HIS   A 1 88  ? 140.309 111.820 -21.410 1.00 73.66  ?  73  HIS   A CA     1 
ATOM   570  C  C      . HIS   A 1 88  ? 141.653 111.090 -21.553 1.00 79.69  ?  73  HIS   A C      1 
ATOM   571  O  O      . HIS   A 1 88  ? 142.576 111.593 -22.200 1.00 79.01  ?  73  HIS   A O      1 
ATOM   572  C  CB     . HIS   A 1 88  ? 139.264 111.280 -22.396 1.00 74.56  ?  73  HIS   A CB     1 
ATOM   573  C  CG     . HIS   A 1 88  ? 139.682 111.340 -23.830 1.00 78.06  ?  73  HIS   A CG     1 
ATOM   574  N  ND1    . HIS   A 1 88  ? 140.256 110.252 -24.456 1.00 79.89  ?  73  HIS   A ND1    1 
ATOM   575  C  CD2    . HIS   A 1 88  ? 139.588 112.355 -24.716 1.00 79.91  ?  73  HIS   A CD2    1 
ATOM   576  C  CE1    . HIS   A 1 88  ? 140.493 110.637 -25.699 1.00 79.40  ?  73  HIS   A CE1    1 
ATOM   577  N  NE2    . HIS   A 1 88  ? 140.097 111.891 -25.905 1.00 79.72  ?  73  HIS   A NE2    1 
ATOM   578  N  N      . LYS   A 1 89  ? 141.742 109.900 -20.943 1.00 78.02  ?  74  LYS   A N      1 
ATOM   579  C  CA     . LYS   A 1 89  ? 142.925 109.033 -20.947 1.00 78.74  ?  74  LYS   A CA     1 
ATOM   580  C  C      . LYS   A 1 89  ? 142.955 108.006 -22.102 1.00 85.05  ?  74  LYS   A C      1 
ATOM   581  O  O      . LYS   A 1 89  ? 143.911 107.229 -22.189 1.00 84.33  ?  74  LYS   A O      1 
ATOM   582  C  CB     . LYS   A 1 89  ? 143.087 108.336 -19.575 1.00 81.43  ?  74  LYS   A CB     1 
ATOM   583  C  CG     . LYS   A 1 89  ? 141.924 107.427 -19.164 1.00 96.10  ?  74  LYS   A CG     1 
ATOM   584  C  CD     . LYS   A 1 89  ? 142.134 106.831 -17.778 1.00 106.69 ?  74  LYS   A CD     1 
ATOM   585  C  CE     . LYS   A 1 89  ? 141.016 105.907 -17.353 1.00 116.78 ?  74  LYS   A CE     1 
ATOM   586  N  NZ     . LYS   A 1 89  ? 141.107 104.576 -18.015 1.00 125.76 1  74  LYS   A NZ     1 
ATOM   587  N  N      A ASN   A 1 90  ? 141.926 108.008 -22.974 0.49 82.89  ?  75  ASN   A N      1 
ATOM   588  N  N      B ASN   A 1 90  ? 141.926 108.009 -22.976 0.51 83.05  ?  75  ASN   A N      1 
ATOM   589  C  CA     A ASN   A 1 90  ? 141.824 107.082 -24.103 0.49 83.35  ?  75  ASN   A CA     1 
ATOM   590  C  CA     B ASN   A 1 90  ? 141.829 107.090 -24.113 0.51 83.59  ?  75  ASN   A CA     1 
ATOM   591  C  C      A ASN   A 1 90  ? 142.602 107.586 -25.336 0.49 88.97  ?  75  ASN   A C      1 
ATOM   592  C  C      B ASN   A 1 90  ? 142.605 107.598 -25.339 0.51 89.07  ?  75  ASN   A C      1 
ATOM   593  O  O      A ASN   A 1 90  ? 142.021 107.854 -26.394 0.49 88.53  ?  75  ASN   A O      1 
ATOM   594  O  O      B ASN   A 1 90  ? 142.027 107.873 -26.396 0.51 88.63  ?  75  ASN   A O      1 
ATOM   595  C  CB     A ASN   A 1 90  ? 140.351 106.757 -24.410 0.49 84.03  ?  75  ASN   A CB     1 
ATOM   596  C  CB     B ASN   A 1 90  ? 140.365 106.755 -24.432 0.51 84.96  ?  75  ASN   A CB     1 
ATOM   597  C  CG     A ASN   A 1 90  ? 140.126 105.475 -25.183 0.49 106.97 ?  75  ASN   A CG     1 
ATOM   598  C  CG     B ASN   A 1 90  ? 139.780 105.656 -23.576 0.51 111.61 ?  75  ASN   A CG     1 
ATOM   599  O  OD1    A ASN   A 1 90  ? 140.832 104.471 -25.020 0.49 100.49 ?  75  ASN   A OD1    1 
ATOM   600  O  OD1    B ASN   A 1 90  ? 140.023 105.566 -22.365 0.51 106.68 ?  75  ASN   A OD1    1 
ATOM   601  N  ND2    A ASN   A 1 90  ? 139.088 105.464 -26.004 0.49 99.73  ?  75  ASN   A ND2    1 
ATOM   602  N  ND2    B ASN   A 1 90  ? 138.951 104.820 -24.179 0.51 104.49 ?  75  ASN   A ND2    1 
ATOM   603  N  N      . MET   A 1 91  ? 143.934 107.715 -25.171 1.00 86.98  ?  76  MET   A N      1 
ATOM   604  C  CA     . MET   A 1 91  ? 144.912 108.167 -26.184 1.00 88.03  ?  76  MET   A CA     1 
ATOM   605  C  C      . MET   A 1 91  ? 146.331 107.812 -25.686 1.00 93.87  ?  76  MET   A C      1 
ATOM   606  O  O      . MET   A 1 91  ? 146.471 107.163 -24.645 1.00 93.61  ?  76  MET   A O      1 
ATOM   607  C  CB     . MET   A 1 91  ? 144.788 109.693 -26.471 1.00 90.53  ?  76  MET   A CB     1 
ATOM   608  C  CG     . MET   A 1 91  ? 144.878 110.585 -25.234 1.00 94.41  ?  76  MET   A CG     1 
ATOM   609  S  SD     . MET   A 1 91  ? 145.095 112.341 -25.631 1.00 98.96  ?  76  MET   A SD     1 
ATOM   610  C  CE     . MET   A 1 91  ? 143.418 112.824 -25.971 1.00 95.58  ?  76  MET   A CE     1 
ATOM   611  N  N      . GLY   A 1 92  ? 147.355 108.238 -26.426 1.00 91.67  ?  77  GLY   A N      1 
ATOM   612  C  CA     . GLY   A 1 92  ? 148.747 108.032 -26.043 1.00 91.96  ?  77  GLY   A CA     1 
ATOM   613  C  C      . GLY   A 1 92  ? 149.142 108.949 -24.900 1.00 96.72  ?  77  GLY   A C      1 
ATOM   614  O  O      . GLY   A 1 92  ? 148.582 110.043 -24.768 1.00 96.20  ?  77  GLY   A O      1 
ATOM   615  N  N      . VAL   A 1 93  ? 150.103 108.508 -24.058 1.00 94.00  ?  78  VAL   A N      1 
ATOM   616  C  CA     . VAL   A 1 93  ? 150.616 109.266 -22.899 1.00 94.22  ?  78  VAL   A CA     1 
ATOM   617  C  C      . VAL   A 1 93  ? 151.175 110.633 -23.354 1.00 98.92  ?  78  VAL   A C      1 
ATOM   618  O  O      . VAL   A 1 93  ? 150.923 111.652 -22.702 1.00 98.54  ?  78  VAL   A O      1 
ATOM   619  C  CB     . VAL   A 1 93  ? 151.652 108.442 -22.075 1.00 98.22  ?  78  VAL   A CB     1 
ATOM   620  C  CG1    . VAL   A 1 93  ? 152.165 109.221 -20.864 1.00 97.92  ?  78  VAL   A CG1    1 
ATOM   621  C  CG2    . VAL   A 1 93  ? 151.072 107.097 -21.634 1.00 98.09  ?  78  VAL   A CG2    1 
ATOM   622  N  N      . GLU   A 1 94  ? 151.893 110.641 -24.498 1.00 96.09  ?  79  GLU   A N      1 
ATOM   623  C  CA     . GLU   A 1 94  ? 152.494 111.831 -25.106 1.00 96.19  ?  79  GLU   A CA     1 
ATOM   624  C  C      . GLU   A 1 94  ? 151.438 112.844 -25.554 1.00 99.30  ?  79  GLU   A C      1 
ATOM   625  O  O      . GLU   A 1 94  ? 151.579 114.032 -25.251 1.00 98.85  ?  79  GLU   A O      1 
ATOM   626  C  CB     . GLU   A 1 94  ? 153.409 111.449 -26.286 1.00 97.77  ?  79  GLU   A CB     1 
ATOM   627  C  CG     . GLU   A 1 94  ? 154.755 110.867 -25.877 1.00 110.55 ?  79  GLU   A CG     1 
ATOM   628  C  CD     . GLU   A 1 94  ? 154.774 109.397 -25.503 1.00 137.47 ?  79  GLU   A CD     1 
ATOM   629  O  OE1    . GLU   A 1 94  ? 155.467 109.049 -24.519 1.00 137.74 ?  79  GLU   A OE1    1 
ATOM   630  O  OE2    . GLU   A 1 94  ? 154.118 108.588 -26.201 1.00 132.97 -1 79  GLU   A OE2    1 
ATOM   631  N  N      . GLU   A 1 95  ? 150.377 112.369 -26.251 1.00 95.33  ?  80  GLU   A N      1 
ATOM   632  C  CA     . GLU   A 1 95  ? 149.282 113.203 -26.764 1.00 95.01  ?  80  GLU   A CA     1 
ATOM   633  C  C      . GLU   A 1 95  ? 148.479 113.893 -25.656 1.00 97.71  ?  80  GLU   A C      1 
ATOM   634  O  O      . GLU   A 1 95  ? 148.121 115.060 -25.819 1.00 97.17  ?  80  GLU   A O      1 
ATOM   635  C  CB     . GLU   A 1 95  ? 148.357 112.401 -27.693 1.00 96.54  ?  80  GLU   A CB     1 
ATOM   636  C  CG     . GLU   A 1 95  ? 147.613 113.269 -28.696 1.00 108.39 ?  80  GLU   A CG     1 
ATOM   637  C  CD     . GLU   A 1 95  ? 146.315 112.687 -29.223 1.00 131.32 ?  80  GLU   A CD     1 
ATOM   638  O  OE1    . GLU   A 1 95  ? 146.366 111.663 -29.943 1.00 128.66 ?  80  GLU   A OE1    1 
ATOM   639  O  OE2    . GLU   A 1 95  ? 145.246 113.274 -28.938 1.00 124.27 -1 80  GLU   A OE2    1 
ATOM   640  N  N      . GLN   A 1 96  ? 148.206 113.179 -24.536 1.00 93.23  ?  81  GLN   A N      1 
ATOM   641  C  CA     . GLN   A 1 96  ? 147.462 113.710 -23.385 1.00 92.40  ?  81  GLN   A CA     1 
ATOM   642  C  C      . GLN   A 1 96  ? 148.226 114.842 -22.709 1.00 94.80  ?  81  GLN   A C      1 
ATOM   643  O  O      . GLN   A 1 96  ? 147.615 115.834 -22.299 1.00 93.98  ?  81  GLN   A O      1 
ATOM   644  C  CB     . GLN   A 1 96  ? 147.101 112.600 -22.388 1.00 93.69  ?  81  GLN   A CB     1 
ATOM   645  C  CG     . GLN   A 1 96  ? 145.801 112.883 -21.627 1.00 109.99 ?  81  GLN   A CG     1 
ATOM   646  C  CD     . GLN   A 1 96  ? 145.489 111.899 -20.520 1.00 128.34 ?  81  GLN   A CD     1 
ATOM   647  O  OE1    . GLN   A 1 96  ? 146.259 110.984 -20.212 1.00 124.77 ?  81  GLN   A OE1    1 
ATOM   648  N  NE2    . GLN   A 1 96  ? 144.345 112.082 -19.879 1.00 118.59 ?  81  GLN   A NE2    1 
ATOM   649  N  N      . ALA   A 1 97  ? 149.567 114.707 -22.632 1.00 90.39  ?  82  ALA   A N      1 
ATOM   650  C  CA     . ALA   A 1 97  ? 150.461 115.727 -22.082 1.00 89.42  ?  82  ALA   A CA     1 
ATOM   651  C  C      . ALA   A 1 97  ? 150.448 116.972 -22.982 1.00 91.73  ?  82  ALA   A C      1 
ATOM   652  O  O      . ALA   A 1 97  ? 150.466 118.091 -22.462 1.00 91.32  ?  82  ALA   A O      1 
ATOM   653  C  CB     . ALA   A 1 97  ? 151.872 115.175 -21.954 1.00 90.10  ?  82  ALA   A CB     1 
ATOM   654  N  N      A ASP   A 1 98  ? 150.390 116.773 -24.316 0.17 87.76  ?  83  ASP   A N      1 
ATOM   655  N  N      B ASP   A 1 98  ? 150.390 116.770 -24.320 0.83 87.93  ?  83  ASP   A N      1 
ATOM   656  C  CA     A ASP   A 1 98  ? 150.360 117.835 -25.325 0.17 87.35  ?  83  ASP   A CA     1 
ATOM   657  C  CA     B ASP   A 1 98  ? 150.355 117.841 -25.324 0.83 87.75  ?  83  ASP   A CA     1 
ATOM   658  C  C      A ASP   A 1 98  ? 149.061 118.656 -25.277 0.17 90.30  ?  83  ASP   A C      1 
ATOM   659  C  C      B ASP   A 1 98  ? 149.059 118.665 -25.262 0.83 90.12  ?  83  ASP   A C      1 
ATOM   660  O  O      A ASP   A 1 98  ? 149.088 119.851 -25.578 0.17 89.71  ?  83  ASP   A O      1 
ATOM   661  O  O      B ASP   A 1 98  ? 149.085 119.866 -25.539 0.83 88.99  ?  83  ASP   A O      1 
ATOM   662  C  CB     A ASP   A 1 98  ? 150.585 117.241 -26.727 0.17 89.23  ?  83  ASP   A CB     1 
ATOM   663  C  CB     B ASP   A 1 98  ? 150.570 117.275 -26.747 0.83 89.90  ?  83  ASP   A CB     1 
ATOM   664  C  CG     A ASP   A 1 98  ? 150.844 118.264 -27.815 0.17 99.09  ?  83  ASP   A CG     1 
ATOM   665  C  CG     B ASP   A 1 98  ? 151.952 116.700 -27.028 0.83 100.71 ?  83  ASP   A CG     1 
ATOM   666  O  OD1    A ASP   A 1 98  ? 151.909 118.919 -27.774 0.17 99.54  ?  83  ASP   A OD1    1 
ATOM   667  O  OD1    B ASP   A 1 98  ? 152.954 117.307 -26.583 0.83 101.41 ?  83  ASP   A OD1    1 
ATOM   668  O  OD2    A ASP   A 1 98  ? 150.004 118.378 -28.730 0.17 104.95 -1 83  ASP   A OD2    1 
ATOM   669  O  OD2    B ASP   A 1 98  ? 152.035 115.678 -27.745 0.83 106.32 -1 83  ASP   A OD2    1 
ATOM   670  N  N      . GLU   A 1 99  ? 147.935 118.015 -24.895 1.00 86.35  ?  84  GLU   A N      1 
ATOM   671  C  CA     . GLU   A 1 99  ? 146.611 118.653 -24.781 1.00 85.43  ?  84  GLU   A CA     1 
ATOM   672  C  C      . GLU   A 1 99  ? 146.545 119.643 -23.610 1.00 87.22  ?  84  GLU   A C      1 
ATOM   673  O  O      . GLU   A 1 99  ? 145.971 120.723 -23.755 1.00 85.84  ?  84  GLU   A O      1 
ATOM   674  C  CB     . GLU   A 1 99  ? 145.493 117.597 -24.674 1.00 86.84  ?  84  GLU   A CB     1 
ATOM   675  C  CG     . GLU   A 1 99  ? 145.292 116.749 -25.922 1.00 96.77  ?  84  GLU   A CG     1 
ATOM   676  C  CD     . GLU   A 1 99  ? 144.774 117.482 -27.144 1.00 120.36 ?  84  GLU   A CD     1 
ATOM   677  O  OE1    . GLU   A 1 99  ? 145.564 117.679 -28.095 1.00 120.76 ?  84  GLU   A OE1    1 
ATOM   678  O  OE2    . GLU   A 1 99  ? 143.581 117.862 -27.151 1.00 113.76 -1 84  GLU   A OE2    1 
ATOM   679  N  N      . VAL   A 1 100 ? 147.161 119.283 -22.468 1.00 83.69  ?  85  VAL   A N      1 
ATOM   680  C  CA     . VAL   A 1 100 ? 147.236 120.105 -21.252 1.00 83.57  ?  85  VAL   A CA     1 
ATOM   681  C  C      . VAL   A 1 100 ? 147.990 121.423 -21.528 1.00 87.90  ?  85  VAL   A C      1 
ATOM   682  O  O      . VAL   A 1 100 ? 147.536 122.489 -21.096 1.00 87.16  ?  85  VAL   A O      1 
ATOM   683  C  CB     . VAL   A 1 100 ? 147.846 119.304 -20.065 1.00 87.43  ?  85  VAL   A CB     1 
ATOM   684  C  CG1    . VAL   A 1 100 ? 148.029 120.178 -18.829 1.00 87.27  ?  85  VAL   A CG1    1 
ATOM   685  C  CG2    . VAL   A 1 100 ? 146.994 118.083 -19.730 1.00 87.24  ?  85  VAL   A CG2    1 
ATOM   686  N  N      . GLN   A 1 101 ? 149.121 121.341 -22.267 1.00 85.08  ?  86  GLN   A N      1 
ATOM   687  C  CA     . GLN   A 1 101 ? 149.958 122.486 -22.641 1.00 85.23  ?  86  GLN   A CA     1 
ATOM   688  C  C      . GLN   A 1 101 ? 149.179 123.518 -23.462 1.00 88.17  ?  86  GLN   A C      1 
ATOM   689  O  O      . GLN   A 1 101 ? 149.304 124.719 -23.212 1.00 86.97  ?  86  GLN   A O      1 
ATOM   690  C  CB     . GLN   A 1 101 ? 151.201 122.016 -23.415 1.00 87.02  ?  86  GLN   A CB     1 
ATOM   691  C  CG     . GLN   A 1 101 ? 152.406 121.728 -22.531 1.00 110.55 ?  86  GLN   A CG     1 
ATOM   692  C  CD     . GLN   A 1 101 ? 153.291 122.940 -22.381 1.00 134.72 ?  86  GLN   A CD     1 
ATOM   693  O  OE1    . GLN   A 1 101 ? 154.126 123.240 -23.242 1.00 130.89 ?  86  GLN   A OE1    1 
ATOM   694  N  NE2    . GLN   A 1 101 ? 153.132 123.660 -21.279 1.00 127.98 ?  86  GLN   A NE2    1 
ATOM   695  N  N      . LYS   A 1 102 ? 148.359 123.039 -24.419 1.00 84.84  ?  87  LYS   A N      1 
ATOM   696  C  CA     . LYS   A 1 102 ? 147.533 123.867 -25.303 1.00 84.87  ?  87  LYS   A CA     1 
ATOM   697  C  C      . LYS   A 1 102 ? 146.545 124.754 -24.543 1.00 89.12  ?  87  LYS   A C      1 
ATOM   698  O  O      . LYS   A 1 102 ? 146.378 125.920 -24.907 1.00 88.58  ?  87  LYS   A O      1 
ATOM   699  C  CB     . LYS   A 1 102 ? 146.806 122.999 -26.341 1.00 87.39  ?  87  LYS   A CB     1 
ATOM   700  C  CG     . LYS   A 1 102 ? 147.730 122.439 -27.415 1.00 99.66  ?  87  LYS   A CG     1 
ATOM   701  C  CD     . LYS   A 1 102 ? 147.001 121.471 -28.325 1.00 108.08 ?  87  LYS   A CD     1 
ATOM   702  C  CE     . LYS   A 1 102 ? 147.899 120.931 -29.406 1.00 115.11 ?  87  LYS   A CE     1 
ATOM   703  N  NZ     . LYS   A 1 102 ? 147.211 119.888 -30.208 1.00 121.96 1  87  LYS   A NZ     1 
ATOM   704  N  N      . VAL   A 1 103 ? 145.917 124.210 -23.478 1.00 86.08  ?  88  VAL   A N      1 
ATOM   705  C  CA     . VAL   A 1 103 ? 144.947 124.924 -22.634 1.00 86.19  ?  88  VAL   A CA     1 
ATOM   706  C  C      . VAL   A 1 103 ? 145.648 126.021 -21.809 1.00 89.95  ?  88  VAL   A C      1 
ATOM   707  O  O      . VAL   A 1 103 ? 145.138 127.142 -21.723 1.00 89.69  ?  88  VAL   A O      1 
ATOM   708  C  CB     . VAL   A 1 103 ? 144.074 123.967 -21.760 1.00 90.19  ?  88  VAL   A CB     1 
ATOM   709  C  CG1    . VAL   A 1 103 ? 142.934 124.720 -21.073 1.00 89.85  ?  88  VAL   A CG1    1 
ATOM   710  C  CG2    . VAL   A 1 103 ? 143.516 122.810 -22.591 1.00 90.06  ?  88  VAL   A CG2    1 
ATOM   711  N  N      . LYS   A 1 104 ? 146.829 125.700 -21.241 1.00 86.27  ?  89  LYS   A N      1 
ATOM   712  C  CA     . LYS   A 1 104 ? 147.647 126.624 -20.447 1.00 85.80  ?  89  LYS   A CA     1 
ATOM   713  C  C      . LYS   A 1 104 ? 148.206 127.783 -21.292 1.00 89.56  ?  89  LYS   A C      1 
ATOM   714  O  O      . LYS   A 1 104 ? 148.269 128.917 -20.805 1.00 89.13  ?  89  LYS   A O      1 
ATOM   715  C  CB     . LYS   A 1 104 ? 148.774 125.878 -19.704 1.00 88.26  ?  89  LYS   A CB     1 
ATOM   716  C  CG     . LYS   A 1 104 ? 148.317 124.822 -18.675 1.00 98.30  ?  89  LYS   A CG     1 
ATOM   717  C  CD     . LYS   A 1 104 ? 147.400 125.350 -17.547 1.00 105.39 ?  89  LYS   A CD     1 
ATOM   718  C  CE     . LYS   A 1 104 ? 148.067 126.265 -16.544 1.00 113.63 ?  89  LYS   A CE     1 
ATOM   719  N  NZ     . LYS   A 1 104 ? 147.088 126.820 -15.572 1.00 120.74 1  89  LYS   A NZ     1 
ATOM   720  N  N      A ARG   A 1 105 ? 148.595 127.498 -22.552 0.49 86.17  ?  90  ARG   A N      1 
ATOM   721  N  N      B ARG   A 1 105 ? 148.590 127.498 -22.552 0.51 85.97  ?  90  ARG   A N      1 
ATOM   722  C  CA     A ARG   A 1 105 ? 149.121 128.493 -23.492 0.49 85.96  ?  90  ARG   A CA     1 
ATOM   723  C  CA     B ARG   A 1 105 ? 149.117 128.489 -23.497 0.51 85.65  ?  90  ARG   A CA     1 
ATOM   724  C  C      A ARG   A 1 105 ? 148.004 129.373 -24.088 0.49 90.00  ?  90  ARG   A C      1 
ATOM   725  C  C      B ARG   A 1 105 ? 148.004 129.377 -24.082 0.51 89.87  ?  90  ARG   A C      1 
ATOM   726  O  O      A ARG   A 1 105 ? 148.299 130.364 -24.763 0.49 89.67  ?  90  ARG   A O      1 
ATOM   727  O  O      B ARG   A 1 105 ? 148.300 130.376 -24.744 0.51 89.56  ?  90  ARG   A O      1 
ATOM   728  C  CB     A ARG   A 1 105 ? 149.947 127.817 -24.602 0.49 85.99  ?  90  ARG   A CB     1 
ATOM   729  C  CB     B ARG   A 1 105 ? 149.912 127.798 -24.619 0.51 85.10  ?  90  ARG   A CB     1 
ATOM   730  C  CG     A ARG   A 1 105 ? 151.457 127.906 -24.388 0.49 95.55  ?  90  ARG   A CG     1 
ATOM   731  C  CG     B ARG   A 1 105 ? 151.327 127.403 -24.220 0.51 92.47  ?  90  ARG   A CG     1 
ATOM   732  C  CD     A ARG   A 1 105 ? 152.060 126.603 -23.894 0.49 104.59 ?  90  ARG   A CD     1 
ATOM   733  C  CD     B ARG   A 1 105 ? 151.999 126.578 -25.297 0.51 97.67  ?  90  ARG   A CD     1 
ATOM   734  N  NE     A ARG   A 1 105 ? 152.225 125.625 -24.972 0.49 112.58 ?  90  ARG   A NE     1 
ATOM   735  N  NE     B ARG   A 1 105 ? 153.395 126.284 -24.968 0.51 102.79 ?  90  ARG   A NE     1 
ATOM   736  C  CZ     A ARG   A 1 105 ? 153.376 125.363 -25.584 0.49 125.67 ?  90  ARG   A CZ     1 
ATOM   737  C  CZ     B ARG   A 1 105 ? 154.168 125.442 -25.648 0.51 114.46 ?  90  ARG   A CZ     1 
ATOM   738  N  NH1    A ARG   A 1 105 ? 154.487 125.997 -25.226 0.49 112.45 1  90  ARG   A NH1    1 
ATOM   739  N  NH1    B ARG   A 1 105 ? 153.687 124.788 -26.698 0.51 101.30 1  90  ARG   A NH1    1 
ATOM   740  N  NH2    A ARG   A 1 105 ? 153.428 124.459 -26.552 0.49 111.81 ?  90  ARG   A NH2    1 
ATOM   741  N  NH2    B ARG   A 1 105 ? 155.425 125.242 -25.278 0.51 99.24  ?  90  ARG   A NH2    1 
ATOM   742  N  N      . SER   A 1 106 ? 146.727 129.019 -23.820 1.00 86.38  ?  91  SER   A N      1 
ATOM   743  C  CA     . SER   A 1 106 ? 145.547 129.751 -24.299 1.00 85.69  ?  91  SER   A CA     1 
ATOM   744  C  C      . SER   A 1 106 ? 145.017 130.805 -23.304 1.00 88.77  ?  91  SER   A C      1 
ATOM   745  O  O      . SER   A 1 106 ? 143.837 131.170 -23.360 1.00 88.65  ?  91  SER   A O      1 
ATOM   746  C  CB     . SER   A 1 106 ? 144.452 128.777 -24.717 1.00 88.85  ?  91  SER   A CB     1 
ATOM   747  O  OG     . SER   A 1 106 ? 144.895 127.991 -25.811 1.00 97.18  ?  91  SER   A OG     1 
ATOM   748  N  N      . GLY   A 1 107 ? 145.903 131.313 -22.442 1.00 84.47  ?  92  GLY   A N      1 
ATOM   749  C  CA     . GLY   A 1 107 ? 145.589 132.363 -21.474 1.00 83.97  ?  92  GLY   A CA     1 
ATOM   750  C  C      . GLY   A 1 107 ? 145.773 132.037 -20.002 1.00 87.13  ?  92  GLY   A C      1 
ATOM   751  O  O      . GLY   A 1 107 ? 145.341 132.818 -19.148 1.00 86.57  ?  92  GLY   A O      1 
ATOM   752  N  N      . GLY   A 1 108 ? 146.426 130.911 -19.704 1.00 83.29  ?  93  GLY   A N      1 
ATOM   753  C  CA     . GLY   A 1 108 ? 146.654 130.453 -18.333 1.00 82.89  ?  93  GLY   A CA     1 
ATOM   754  C  C      . GLY   A 1 108 ? 145.358 130.015 -17.681 1.00 85.68  ?  93  GLY   A C      1 
ATOM   755  O  O      . GLY   A 1 108 ? 145.004 130.490 -16.597 1.00 85.44  ?  93  GLY   A O      1 
ATOM   756  N  N      . LEU   A 1 109 ? 144.624 129.135 -18.375 1.00 81.02  ?  220 LEU   A N      1 
ATOM   757  C  CA     . LEU   A 1 109 ? 143.316 128.637 -17.957 1.00 80.37  ?  220 LEU   A CA     1 
ATOM   758  C  C      . LEU   A 1 109 ? 143.412 127.370 -17.107 1.00 84.21  ?  220 LEU   A C      1 
ATOM   759  O  O      . LEU   A 1 109 ? 144.404 126.644 -17.192 1.00 83.60  ?  220 LEU   A O      1 
ATOM   760  C  CB     . LEU   A 1 109 ? 142.422 128.393 -19.195 1.00 80.15  ?  220 LEU   A CB     1 
ATOM   761  C  CG     . LEU   A 1 109 ? 142.012 129.622 -20.035 1.00 84.23  ?  220 LEU   A CG     1 
ATOM   762  C  CD1    . LEU   A 1 109 ? 141.610 129.218 -21.439 1.00 84.10  ?  220 LEU   A CD1    1 
ATOM   763  C  CD2    . LEU   A 1 109 ? 140.885 130.408 -19.377 1.00 85.87  ?  220 LEU   A CD2    1 
ATOM   764  N  N      . LEU   A 1 110 ? 142.374 127.111 -16.284 1.00 80.92  ?  221 LEU   A N      1 
ATOM   765  C  CA     . LEU   A 1 110 ? 142.283 125.917 -15.439 1.00 80.24  ?  221 LEU   A CA     1 
ATOM   766  C  C      . LEU   A 1 110 ? 142.022 124.703 -16.328 1.00 82.41  ?  221 LEU   A C      1 
ATOM   767  O  O      . LEU   A 1 110 ? 141.214 124.790 -17.253 1.00 82.03  ?  221 LEU   A O      1 
ATOM   768  C  CB     . LEU   A 1 110 ? 141.160 126.076 -14.396 1.00 80.34  ?  221 LEU   A CB     1 
ATOM   769  C  CG     . LEU   A 1 110 ? 141.492 126.892 -13.146 1.00 85.25  ?  221 LEU   A CG     1 
ATOM   770  C  CD1    . LEU   A 1 110 ? 140.253 127.553 -12.591 1.00 85.58  ?  221 LEU   A CD1    1 
ATOM   771  C  CD2    . LEU   A 1 110 ? 142.129 126.025 -12.068 1.00 88.35  ?  221 LEU   A CD2    1 
ATOM   772  N  N      . VAL   A 1 111 ? 142.732 123.590 -16.077 1.00 78.02  ?  222 VAL   A N      1 
ATOM   773  C  CA     . VAL   A 1 111 ? 142.601 122.362 -16.868 1.00 77.64  ?  222 VAL   A CA     1 
ATOM   774  C  C      . VAL   A 1 111 ? 142.737 121.103 -15.987 1.00 81.10  ?  222 VAL   A C      1 
ATOM   775  O  O      . VAL   A 1 111 ? 143.485 121.109 -15.004 1.00 80.95  ?  222 VAL   A O      1 
ATOM   776  C  CB     . VAL   A 1 111 ? 143.563 122.364 -18.102 1.00 81.73  ?  222 VAL   A CB     1 
ATOM   777  C  CG1    . VAL   A 1 111 ? 145.038 122.313 -17.697 1.00 81.55  ?  222 VAL   A CG1    1 
ATOM   778  C  CG2    . VAL   A 1 111 ? 143.221 121.259 -19.102 1.00 81.52  ?  222 VAL   A CG2    1 
ATOM   779  N  N      . ALA   A 1 112 ? 141.997 120.035 -16.346 1.00 76.68  ?  223 ALA   A N      1 
ATOM   780  C  CA     . ALA   A 1 112 ? 141.993 118.748 -15.650 1.00 75.94  ?  223 ALA   A CA     1 
ATOM   781  C  C      . ALA   A 1 112 ? 142.292 117.607 -16.620 1.00 78.83  ?  223 ALA   A C      1 
ATOM   782  O  O      . ALA   A 1 112 ? 142.074 117.749 -17.826 1.00 77.64  ?  223 ALA   A O      1 
ATOM   783  C  CB     . ALA   A 1 112 ? 140.642 118.525 -14.984 1.00 76.75  ?  223 ALA   A CB     1 
ATOM   784  N  N      . ALA   A 1 113 ? 142.780 116.470 -16.092 1.00 75.99  ?  224 ALA   A N      1 
ATOM   785  C  CA     . ALA   A 1 113 ? 143.105 115.283 -16.888 1.00 76.10  ?  224 ALA   A CA     1 
ATOM   786  C  C      . ALA   A 1 113 ? 142.758 114.003 -16.142 1.00 80.79  ?  224 ALA   A C      1 
ATOM   787  O  O      . ALA   A 1 113 ? 142.811 113.983 -14.913 1.00 80.25  ?  224 ALA   A O      1 
ATOM   788  C  CB     . ALA   A 1 113 ? 144.579 115.291 -17.262 1.00 76.89  ?  224 ALA   A CB     1 
ATOM   789  N  N      . ALA   A 1 114 ? 142.420 112.935 -16.890 1.00 78.46  ?  225 ALA   A N      1 
ATOM   790  C  CA     . ALA   A 1 114 ? 142.029 111.634 -16.353 1.00 79.23  ?  225 ALA   A CA     1 
ATOM   791  C  C      . ALA   A 1 114 ? 143.169 110.623 -16.307 1.00 86.81  ?  225 ALA   A C      1 
ATOM   792  O  O      . ALA   A 1 114 ? 144.017 110.609 -17.201 1.00 86.81  ?  225 ALA   A O      1 
ATOM   793  C  CB     . ALA   A 1 114 ? 140.869 111.068 -17.157 1.00 79.86  ?  225 ALA   A CB     1 
ATOM   794  N  N      . ILE   A 1 115 ? 143.160 109.755 -15.271 1.00 85.54  ?  226 ILE   A N      1 
ATOM   795  C  CA     . ILE   A 1 115 ? 144.132 108.675 -15.023 1.00 86.32  ?  226 ILE   A CA     1 
ATOM   796  C  C      . ILE   A 1 115 ? 143.441 107.432 -14.453 1.00 92.35  ?  226 ILE   A C      1 
ATOM   797  O  O      . ILE   A 1 115 ? 142.376 107.546 -13.841 1.00 92.31  ?  226 ILE   A O      1 
ATOM   798  C  CB     . ILE   A 1 115 ? 145.342 109.116 -14.149 1.00 89.61  ?  226 ILE   A CB     1 
ATOM   799  C  CG1    . ILE   A 1 115 ? 144.905 109.989 -12.940 1.00 90.12  ?  226 ILE   A CG1    1 
ATOM   800  C  CG2    . ILE   A 1 115 ? 146.426 109.793 -15.002 1.00 90.27  ?  226 ILE   A CG2    1 
ATOM   801  C  CD1    . ILE   A 1 115 ? 145.865 109.976 -11.737 1.00 97.23  ?  226 ILE   A CD1    1 
ATOM   802  N  N      . GLY   A 1 116 ? 144.048 106.263 -14.668 1.00 90.19  ?  227 GLY   A N      1 
ATOM   803  C  CA     . GLY   A 1 116 ? 143.519 104.984 -14.203 1.00 90.64  ?  227 GLY   A CA     1 
ATOM   804  C  C      . GLY   A 1 116 ? 144.183 104.453 -12.948 1.00 96.30  ?  227 GLY   A C      1 
ATOM   805  O  O      . GLY   A 1 116 ? 144.550 105.228 -12.061 1.00 95.87  ?  227 GLY   A O      1 
ATOM   806  N  N      . ILE   A 1 117 ? 144.305 103.114 -12.853 1.00 94.23  ?  228 ILE   A N      1 
ATOM   807  C  CA     . ILE   A 1 117 ? 144.936 102.405 -11.726 1.00 94.77  ?  228 ILE   A CA     1 
ATOM   808  C  C      . ILE   A 1 117 ? 145.969 101.370 -12.212 1.00 100.44 ?  228 ILE   A C      1 
ATOM   809  O  O      . ILE   A 1 117 ? 146.567 100.665 -11.395 1.00 99.92  ?  228 ILE   A O      1 
ATOM   810  C  CB     . ILE   A 1 117 ? 143.909 101.791 -10.725 1.00 97.88  ?  228 ILE   A CB     1 
ATOM   811  C  CG1    . ILE   A 1 117 ? 142.919 100.829 -11.414 1.00 98.29  ?  228 ILE   A CG1    1 
ATOM   812  C  CG2    . ILE   A 1 117 ? 143.191 102.867 -9.918  1.00 98.69  ?  228 ILE   A CG2    1 
ATOM   813  C  CD1    . ILE   A 1 117 ? 142.916 99.458  -10.831 1.00 105.64 ?  228 ILE   A CD1    1 
ATOM   814  N  N      . SER   A 1 118 ? 146.176 101.295 -13.542 1.00 98.30  ?  229 SER   A N      1 
ATOM   815  C  CA     . SER   A 1 118 ? 147.105 100.373 -14.197 1.00 98.76  ?  229 SER   A CA     1 
ATOM   816  C  C      . SER   A 1 118 ? 148.578 100.821 -14.081 1.00 103.96 ?  229 SER   A C      1 
ATOM   817  O  O      . SER   A 1 118 ? 148.881 101.771 -13.351 1.00 103.58 ?  229 SER   A O      1 
ATOM   818  C  CB     . SER   A 1 118 ? 146.700 100.157 -15.654 1.00 102.48 ?  229 SER   A CB     1 
ATOM   819  O  OG     . SER   A 1 118 ? 146.555 101.385 -16.349 1.00 111.32 ?  229 SER   A OG     1 
ATOM   820  N  N      . LYS   A 1 119 ? 149.490 100.113 -14.784 1.00 101.16 ?  230 LYS   A N      1 
ATOM   821  C  CA     . LYS   A 1 119 ? 150.932 100.375 -14.779 1.00 101.12 ?  230 LYS   A CA     1 
ATOM   822  C  C      . LYS   A 1 119 ? 151.308 101.730 -15.400 1.00 105.29 ?  230 LYS   A C      1 
ATOM   823  O  O      . LYS   A 1 119 ? 152.116 102.461 -14.820 1.00 104.69 ?  230 LYS   A O      1 
ATOM   824  C  CB     . LYS   A 1 119 ? 151.683 99.223  -15.468 1.00 103.68 ?  230 LYS   A CB     1 
ATOM   825  C  CG     . LYS   A 1 119 ? 152.888 98.707  -14.683 1.00 120.56 ?  230 LYS   A CG     1 
ATOM   826  C  CD     . LYS   A 1 119 ? 152.527 97.575  -13.714 1.00 131.09 ?  230 LYS   A CD     1 
ATOM   827  C  CE     . LYS   A 1 119 ? 152.589 98.013  -12.270 1.00 141.53 ?  230 LYS   A CE     1 
ATOM   828  N  NZ     . LYS   A 1 119 ? 152.278 96.893  -11.343 1.00 150.35 1  230 LYS   A NZ     1 
ATOM   829  N  N      . ASP   A 1 120 ? 150.693 102.070 -16.558 1.00 101.97 ?  231 ASP   A N      1 
ATOM   830  C  CA     . ASP   A 1 120 ? 150.921 103.306 -17.321 1.00 101.73 ?  231 ASP   A CA     1 
ATOM   831  C  C      . ASP   A 1 120 ? 150.562 104.606 -16.575 1.00 105.69 ?  231 ASP   A C      1 
ATOM   832  O  O      . ASP   A 1 120 ? 150.973 105.680 -17.013 1.00 104.98 ?  231 ASP   A O      1 
ATOM   833  C  CB     . ASP   A 1 120 ? 150.193 103.247 -18.680 1.00 103.53 ?  231 ASP   A CB     1 
ATOM   834  C  CG     . ASP   A 1 120 ? 148.679 103.226 -18.582 1.00 113.32 ?  231 ASP   A CG     1 
ATOM   835  O  OD1    . ASP   A 1 120 ? 148.109 102.123 -18.460 1.00 113.85 ?  231 ASP   A OD1    1 
ATOM   836  O  OD2    . ASP   A 1 120 ? 148.064 104.313 -18.649 1.00 119.12 -1 231 ASP   A OD2    1 
ATOM   837  N  N      . THR   A 1 121 ? 149.803 104.503 -15.464 1.00 102.57 ?  232 THR   A N      1 
ATOM   838  C  CA     . THR   A 1 121 ? 149.337 105.618 -14.633 1.00 102.51 ?  232 THR   A CA     1 
ATOM   839  C  C      . THR   A 1 121 ? 150.481 106.451 -14.042 1.00 106.64 ?  232 THR   A C      1 
ATOM   840  O  O      . THR   A 1 121 ? 150.451 107.679 -14.151 1.00 106.04 ?  232 THR   A O      1 
ATOM   841  C  CB     . THR   A 1 121 ? 148.384 105.105 -13.536 1.00 110.69 ?  232 THR   A CB     1 
ATOM   842  O  OG1    . THR   A 1 121 ? 147.495 104.129 -14.082 1.00 111.24 ?  232 THR   A OG1    1 
ATOM   843  C  CG2    . THR   A 1 121 ? 147.591 106.224 -12.877 1.00 109.03 ?  232 THR   A CG2    1 
ATOM   844  N  N      . ASP   A 1 122 ? 151.468 105.780 -13.408 1.00 103.53 ?  233 ASP   A N      1 
ATOM   845  C  CA     . ASP   A 1 122 ? 152.629 106.390 -12.743 1.00 103.43 ?  233 ASP   A CA     1 
ATOM   846  C  C      . ASP   A 1 122 ? 153.412 107.348 -13.649 1.00 107.85 ?  233 ASP   A C      1 
ATOM   847  O  O      . ASP   A 1 122 ? 153.770 108.445 -13.213 1.00 107.00 ?  233 ASP   A O      1 
ATOM   848  C  CB     . ASP   A 1 122 ? 153.548 105.307 -12.147 1.00 105.03 ?  233 ASP   A CB     1 
ATOM   849  C  CG     . ASP   A 1 122 ? 152.824 104.307 -11.263 1.00 113.46 ?  233 ASP   A CG     1 
ATOM   850  O  OD1    . ASP   A 1 122 ? 152.221 103.356 -11.811 1.00 113.27 ?  233 ASP   A OD1    1 
ATOM   851  O  OD2    . ASP   A 1 122 ? 152.853 104.479 -10.025 1.00 119.02 -1 233 ASP   A OD2    1 
ATOM   852  N  N      . ILE   A 1 123 ? 153.641 106.946 -14.913 1.00 105.45 ?  234 ILE   A N      1 
ATOM   853  C  CA     . ILE   A 1 123 ? 154.352 107.750 -15.915 1.00 105.86 ?  234 ILE   A CA     1 
ATOM   854  C  C      . ILE   A 1 123 ? 153.421 108.768 -16.594 1.00 110.16 ?  234 ILE   A C      1 
ATOM   855  O  O      . ILE   A 1 123 ? 153.890 109.823 -17.029 1.00 109.99 ?  234 ILE   A O      1 
ATOM   856  C  CB     . ILE   A 1 123 ? 155.147 106.889 -16.940 1.00 109.27 ?  234 ILE   A CB     1 
ATOM   857  C  CG1    . ILE   A 1 123 ? 154.297 105.729 -17.524 1.00 109.75 ?  234 ILE   A CG1    1 
ATOM   858  C  CG2    . ILE   A 1 123 ? 156.458 106.379 -16.318 1.00 110.28 ?  234 ILE   A CG2    1 
ATOM   859  C  CD1    . ILE   A 1 123 ? 154.691 105.273 -18.936 1.00 117.26 ?  234 ILE   A CD1    1 
ATOM   860  N  N      . ARG   A 1 124 ? 152.107 108.460 -16.664 1.00 106.62 ?  235 ARG   A N      1 
ATOM   861  C  CA     . ARG   A 1 124 ? 151.087 109.341 -17.241 1.00 106.31 ?  235 ARG   A CA     1 
ATOM   862  C  C      . ARG   A 1 124 ? 150.877 110.562 -16.337 1.00 110.54 ?  235 ARG   A C      1 
ATOM   863  O  O      . ARG   A 1 124 ? 150.828 111.685 -16.838 1.00 110.23 ?  235 ARG   A O      1 
ATOM   864  C  CB     . ARG   A 1 124 ? 149.764 108.580 -17.445 1.00 105.68 ?  235 ARG   A CB     1 
ATOM   865  C  CG     . ARG   A 1 124 ? 148.802 109.233 -18.429 1.00 112.14 ?  235 ARG   A CG     1 
ATOM   866  C  CD     . ARG   A 1 124 ? 147.553 108.397 -18.620 1.00 115.64 ?  235 ARG   A CD     1 
ATOM   867  N  NE     . ARG   A 1 124 ? 147.742 107.318 -19.593 1.00 119.17 ?  235 ARG   A NE     1 
ATOM   868  C  CZ     . ARG   A 1 124 ? 147.478 107.420 -20.893 1.00 127.56 ?  235 ARG   A CZ     1 
ATOM   869  N  NH1    . ARG   A 1 124 ? 147.024 108.561 -21.397 1.00 110.96 1  235 ARG   A NH1    1 
ATOM   870  N  NH2    . ARG   A 1 124 ? 147.669 106.385 -21.698 1.00 113.14 ?  235 ARG   A NH2    1 
ATOM   871  N  N      . ALA   A 1 125 ? 150.793 110.338 -15.008 1.00 107.16 ?  236 ALA   A N      1 
ATOM   872  C  CA     . ALA   A 1 125 ? 150.605 111.373 -13.988 1.00 106.97 ?  236 ALA   A CA     1 
ATOM   873  C  C      . ALA   A 1 125 ? 151.736 112.409 -13.948 1.00 110.99 ?  236 ALA   A C      1 
ATOM   874  O  O      . ALA   A 1 125 ? 151.464 113.584 -13.687 1.00 110.01 ?  236 ALA   A O      1 
ATOM   875  C  CB     . ALA   A 1 125 ? 150.433 110.731 -12.620 1.00 107.68 ?  236 ALA   A CB     1 
ATOM   876  N  N      A GLN   A 1 126 ? 152.984 111.971 -14.211 0.46 107.86 ?  237 GLN   A N      1 
ATOM   877  N  N      B GLN   A 1 126 ? 152.990 111.979 -14.204 0.54 107.93 ?  237 GLN   A N      1 
ATOM   878  C  CA     A GLN   A 1 126 ? 154.183 112.811 -14.219 0.46 107.73 ?  237 GLN   A CA     1 
ATOM   879  C  CA     B GLN   A 1 126 ? 154.164 112.858 -14.204 0.54 107.83 ?  237 GLN   A CA     1 
ATOM   880  C  C      A GLN   A 1 126 ? 154.178 113.789 -15.401 0.46 111.43 ?  237 GLN   A C      1 
ATOM   881  C  C      B GLN   A 1 126 ? 154.160 113.812 -15.405 0.54 111.46 ?  237 GLN   A C      1 
ATOM   882  O  O      A GLN   A 1 126 ? 154.444 114.976 -15.206 0.46 110.89 ?  237 GLN   A O      1 
ATOM   883  O  O      B GLN   A 1 126 ? 154.409 115.005 -15.225 0.54 110.89 ?  237 GLN   A O      1 
ATOM   884  C  CB     A GLN   A 1 126 ? 155.446 111.931 -14.233 0.46 109.14 ?  237 GLN   A CB     1 
ATOM   885  C  CB     B GLN   A 1 126 ? 155.470 112.039 -14.135 0.54 109.27 ?  237 GLN   A CB     1 
ATOM   886  C  CG     A GLN   A 1 126 ? 156.704 112.629 -13.714 0.46 125.14 ?  237 GLN   A CG     1 
ATOM   887  C  CG     B GLN   A 1 126 ? 156.730 112.862 -13.834 0.54 126.02 ?  237 GLN   A CG     1 
ATOM   888  C  CD     A GLN   A 1 126 ? 157.732 112.910 -14.788 0.46 143.83 ?  237 GLN   A CD     1 
ATOM   889  C  CD     B GLN   A 1 126 ? 156.783 113.375 -12.414 0.54 145.75 ?  237 GLN   A CD     1 
ATOM   890  O  OE1    A GLN   A 1 126 ? 157.874 112.178 -15.777 0.46 139.52 ?  237 GLN   A OE1    1 
ATOM   891  O  OE1    B GLN   A 1 126 ? 157.075 112.636 -11.468 0.54 141.89 ?  237 GLN   A OE1    1 
ATOM   892  N  NE2    A GLN   A 1 126 ? 158.522 113.952 -14.580 0.46 135.23 ?  237 GLN   A NE2    1 
ATOM   893  N  NE2    B GLN   A 1 126 ? 156.516 114.660 -12.237 0.54 137.15 ?  237 GLN   A NE2    1 
ATOM   894  N  N      . LYS   A 1 127 ? 153.862 113.292 -16.615 1.00 108.04 ?  238 LYS   A N      1 
ATOM   895  C  CA     . LYS   A 1 127 ? 153.809 114.089 -17.851 1.00 108.02 ?  238 LYS   A CA     1 
ATOM   896  C  C      . LYS   A 1 127 ? 152.677 115.116 -17.871 1.00 111.76 ?  238 LYS   A C      1 
ATOM   897  O  O      . LYS   A 1 127 ? 152.834 116.171 -18.490 1.00 111.42 ?  238 LYS   A O      1 
ATOM   898  C  CB     . LYS   A 1 127 ? 153.761 113.189 -19.099 1.00 110.91 ?  238 LYS   A CB     1 
ATOM   899  C  CG     . LYS   A 1 127 ? 155.130 112.654 -19.526 1.00 128.71 ?  238 LYS   A CG     1 
ATOM   900  C  CD     . LYS   A 1 127 ? 155.941 113.674 -20.344 1.00 140.06 ?  238 LYS   A CD     1 
ATOM   901  C  CE     . LYS   A 1 127 ? 157.404 113.309 -20.470 1.00 151.94 ?  238 LYS   A CE     1 
ATOM   902  N  NZ     . LYS   A 1 127 ? 157.631 112.198 -21.434 1.00 161.31 1  238 LYS   A NZ     1 
ATOM   903  N  N      . LEU   A 1 128 ? 151.553 114.824 -17.183 1.00 108.00 ?  239 LEU   A N      1 
ATOM   904  C  CA     . LEU   A 1 128 ? 150.410 115.738 -17.102 1.00 107.59 ?  239 LEU   A CA     1 
ATOM   905  C  C      . LEU   A 1 128 ? 150.700 116.925 -16.176 1.00 110.27 ?  239 LEU   A C      1 
ATOM   906  O  O      . LEU   A 1 128 ? 150.385 118.059 -16.541 1.00 109.63 ?  239 LEU   A O      1 
ATOM   907  C  CB     . LEU   A 1 128 ? 149.118 115.008 -16.687 1.00 107.79 ?  239 LEU   A CB     1 
ATOM   908  C  CG     . LEU   A 1 128 ? 148.592 113.930 -17.648 1.00 112.69 ?  239 LEU   A CG     1 
ATOM   909  C  CD1    . LEU   A 1 128 ? 147.655 112.975 -16.938 1.00 112.96 ?  239 LEU   A CD1    1 
ATOM   910  C  CD2    . LEU   A 1 128 ? 147.923 114.535 -18.873 1.00 115.23 ?  239 LEU   A CD2    1 
ATOM   911  N  N      . VAL   A 1 129 ? 151.322 116.667 -14.998 1.00 106.20 ?  240 VAL   A N      1 
ATOM   912  C  CA     . VAL   A 1 129 ? 151.705 117.687 -14.005 1.00 105.72 ?  240 VAL   A CA     1 
ATOM   913  C  C      . VAL   A 1 129 ? 152.764 118.619 -14.606 1.00 108.82 ?  240 VAL   A C      1 
ATOM   914  O  O      . VAL   A 1 129 ? 152.656 119.839 -14.454 1.00 108.19 ?  240 VAL   A O      1 
ATOM   915  C  CB     . VAL   A 1 129 ? 152.148 117.064 -12.645 1.00 109.71 ?  240 VAL   A CB     1 
ATOM   916  C  CG1    . VAL   A 1 129 ? 152.692 118.122 -11.682 1.00 109.44 ?  240 VAL   A CG1    1 
ATOM   917  C  CG2    . VAL   A 1 129 ? 151.003 116.302 -11.990 1.00 109.55 ?  240 VAL   A CG2    1 
ATOM   918  N  N      . GLU   A 1 130 ? 153.757 118.038 -15.320 1.00 105.07 ?  241 GLU   A N      1 
ATOM   919  C  CA     . GLU   A 1 130 ? 154.840 118.755 -16.004 1.00 104.75 ?  241 GLU   A CA     1 
ATOM   920  C  C      . GLU   A 1 130 ? 154.280 119.810 -16.963 1.00 107.94 ?  241 GLU   A C      1 
ATOM   921  O  O      . GLU   A 1 130 ? 154.729 120.957 -16.940 1.00 107.48 ?  241 GLU   A O      1 
ATOM   922  C  CB     . GLU   A 1 130 ? 155.730 117.772 -16.781 1.00 106.14 ?  241 GLU   A CB     1 
ATOM   923  C  CG     . GLU   A 1 130 ? 156.886 117.208 -15.978 1.00 117.10 ?  241 GLU   A CG     1 
ATOM   924  C  CD     . GLU   A 1 130 ? 157.805 116.315 -16.785 1.00 136.44 ?  241 GLU   A CD     1 
ATOM   925  O  OE1    . GLU   A 1 130 ? 157.398 115.176 -17.108 1.00 129.02 ?  241 GLU   A OE1    1 
ATOM   926  O  OE2    . GLU   A 1 130 ? 158.936 116.754 -17.095 1.00 130.97 -1 241 GLU   A OE2    1 
ATOM   927  N  N      . ALA   A 1 131 ? 153.265 119.420 -17.767 1.00 103.83 ?  242 ALA   A N      1 
ATOM   928  C  CA     . ALA   A 1 131 ? 152.583 120.264 -18.750 1.00 103.30 ?  242 ALA   A CA     1 
ATOM   929  C  C      . ALA   A 1 131 ? 151.874 121.483 -18.134 1.00 106.33 ?  242 ALA   A C      1 
ATOM   930  O  O      . ALA   A 1 131 ? 151.661 122.476 -18.833 1.00 105.98 ?  242 ALA   A O      1 
ATOM   931  C  CB     . ALA   A 1 131 ? 151.606 119.430 -19.561 1.00 103.96 ?  242 ALA   A CB     1 
ATOM   932  N  N      . GLY   A 1 132 ? 151.540 121.396 -16.844 1.00 102.01 ?  243 GLY   A N      1 
ATOM   933  C  CA     . GLY   A 1 132 ? 150.903 122.472 -16.089 1.00 101.36 ?  243 GLY   A CA     1 
ATOM   934  C  C      . GLY   A 1 132 ? 149.473 122.229 -15.646 1.00 103.96 ?  243 GLY   A C      1 
ATOM   935  O  O      . GLY   A 1 132 ? 148.743 123.195 -15.408 1.00 103.12 ?  243 GLY   A O      1 
ATOM   936  N  N      . VAL   A 1 133 ? 149.064 120.942 -15.502 1.00 99.85  ?  244 VAL   A N      1 
ATOM   937  C  CA     . VAL   A 1 133 ? 147.711 120.560 -15.078 1.00 99.24  ?  244 VAL   A CA     1 
ATOM   938  C  C      . VAL   A 1 133 ? 147.426 121.045 -13.644 1.00 102.11 ?  244 VAL   A C      1 
ATOM   939  O  O      . VAL   A 1 133 ? 148.339 121.113 -12.817 1.00 102.12 ?  244 VAL   A O      1 
ATOM   940  C  CB     . VAL   A 1 133 ? 147.410 119.044 -15.297 1.00 103.10 ?  244 VAL   A CB     1 
ATOM   941  C  CG1    . VAL   A 1 133 ? 147.919 118.168 -14.153 1.00 102.76 ?  244 VAL   A CG1    1 
ATOM   942  C  CG2    . VAL   A 1 133 ? 145.927 118.800 -15.560 1.00 102.96 ?  244 VAL   A CG2    1 
ATOM   943  N  N      . ASP   A 1 134 ? 146.170 121.436 -13.385 1.00 97.23  ?  245 ASP   A N      1 
ATOM   944  C  CA     . ASP   A 1 134 ? 145.727 121.934 -12.084 1.00 96.19  ?  245 ASP   A CA     1 
ATOM   945  C  C      . ASP   A 1 134 ? 145.164 120.804 -11.224 1.00 97.34  ?  245 ASP   A C      1 
ATOM   946  O  O      . ASP   A 1 134 ? 145.360 120.809 -10.007 1.00 96.64  ?  245 ASP   A O      1 
ATOM   947  C  CB     . ASP   A 1 134 ? 144.663 123.034 -12.258 1.00 98.16  ?  245 ASP   A CB     1 
ATOM   948  C  CG     . ASP   A 1 134 ? 145.090 124.173 -13.158 1.00 109.64 ?  245 ASP   A CG     1 
ATOM   949  O  OD1    . ASP   A 1 134 ? 145.492 125.231 -12.625 1.00 110.19 ?  245 ASP   A OD1    1 
ATOM   950  O  OD2    . ASP   A 1 134 ? 145.013 124.011 -14.396 1.00 116.25 -1 245 ASP   A OD2    1 
ATOM   951  N  N      . VAL   A 1 135 ? 144.455 119.846 -11.857 1.00 92.00  ?  246 VAL   A N      1 
ATOM   952  C  CA     . VAL   A 1 135 ? 143.798 118.745 -11.150 1.00 90.88  ?  246 VAL   A CA     1 
ATOM   953  C  C      . VAL   A 1 135 ? 143.888 117.411 -11.917 1.00 92.22  ?  246 VAL   A C      1 
ATOM   954  O  O      . VAL   A 1 135 ? 143.738 117.380 -13.137 1.00 91.32  ?  246 VAL   A O      1 
ATOM   955  C  CB     . VAL   A 1 135 ? 142.332 119.116 -10.736 1.00 94.72  ?  246 VAL   A CB     1 
ATOM   956  C  CG1    . VAL   A 1 135 ? 141.654 120.041 -11.745 1.00 94.38  ?  246 VAL   A CG1    1 
ATOM   957  C  CG2    . VAL   A 1 135 ? 141.471 117.890 -10.458 1.00 94.56  ?  246 VAL   A CG2    1 
ATOM   958  N  N      . LEU   A 1 136 ? 144.144 116.314 -11.167 1.00 87.42  ?  247 LEU   A N      1 
ATOM   959  C  CA     . LEU   A 1 136 ? 144.216 114.937 -11.662 1.00 86.38  ?  247 LEU   A CA     1 
ATOM   960  C  C      . LEU   A 1 136 ? 142.962 114.171 -11.238 1.00 88.08  ?  247 LEU   A C      1 
ATOM   961  O  O      . LEU   A 1 136 ? 142.573 114.220 -10.067 1.00 87.67  ?  247 LEU   A O      1 
ATOM   962  C  CB     . LEU   A 1 136 ? 145.472 114.230 -11.134 1.00 86.46  ?  247 LEU   A CB     1 
ATOM   963  C  CG     . LEU   A 1 136 ? 146.802 114.644 -11.768 1.00 91.13  ?  247 LEU   A CG     1 
ATOM   964  C  CD1    . LEU   A 1 136 ? 147.959 114.336 -10.837 1.00 91.18  ?  247 LEU   A CD1    1 
ATOM   965  C  CD2    . LEU   A 1 136 ? 147.004 113.975 -13.130 1.00 93.19  ?  247 LEU   A CD2    1 
ATOM   966  N  N      . VAL   A 1 137 ? 142.321 113.478 -12.194 1.00 82.67  ?  248 VAL   A N      1 
ATOM   967  C  CA     . VAL   A 1 137 ? 141.078 112.743 -11.960 1.00 81.41  ?  248 VAL   A CA     1 
ATOM   968  C  C      . VAL   A 1 137 ? 141.286 111.237 -12.082 1.00 83.99  ?  248 VAL   A C      1 
ATOM   969  O  O      . VAL   A 1 137 ? 141.557 110.745 -13.178 1.00 84.05  ?  248 VAL   A O      1 
ATOM   970  C  CB     . VAL   A 1 137 ? 139.927 113.243 -12.885 1.00 85.19  ?  248 VAL   A CB     1 
ATOM   971  C  CG1    . VAL   A 1 137 ? 138.608 112.540 -12.565 1.00 84.96  ?  248 VAL   A CG1    1 
ATOM   972  C  CG2    . VAL   A 1 137 ? 139.758 114.760 -12.804 1.00 84.98  ?  248 VAL   A CG2    1 
ATOM   973  N  N      . ILE   A 1 138 ? 141.121 110.496 -10.974 1.00 79.21  ?  249 ILE   A N      1 
ATOM   974  C  CA     . ILE   A 1 138 ? 141.229 109.038 -11.018 1.00 78.49  ?  249 ILE   A CA     1 
ATOM   975  C  C      . ILE   A 1 138 ? 139.878 108.509 -11.531 1.00 81.91  ?  249 ILE   A C      1 
ATOM   976  O  O      . ILE   A 1 138 ? 138.954 108.281 -10.748 1.00 81.86  ?  249 ILE   A O      1 
ATOM   977  C  CB     . ILE   A 1 138 ? 141.727 108.411 -9.678  1.00 81.47  ?  249 ILE   A CB     1 
ATOM   978  C  CG1    . ILE   A 1 138 ? 143.130 108.964 -9.316  1.00 81.83  ?  249 ILE   A CG1    1 
ATOM   979  C  CG2    . ILE   A 1 138 ? 141.748 106.871 -9.760  1.00 82.20  ?  249 ILE   A CG2    1 
ATOM   980  C  CD1    . ILE   A 1 138 ? 143.673 108.618 -7.941  1.00 87.37  ?  249 ILE   A CD1    1 
ATOM   981  N  N      . ASP   A 1 139 ? 139.750 108.410 -12.870 1.00 77.55  ?  250 ASP   A N      1 
ATOM   982  C  CA     . ASP   A 1 139 ? 138.525 107.979 -13.543 1.00 76.50  ?  250 ASP   A CA     1 
ATOM   983  C  C      . ASP   A 1 139 ? 138.379 106.474 -13.566 1.00 77.42  ?  250 ASP   A C      1 
ATOM   984  O  O      . ASP   A 1 139 ? 139.029 105.794 -14.363 1.00 77.70  ?  250 ASP   A O      1 
ATOM   985  C  CB     . ASP   A 1 139 ? 138.415 108.571 -14.963 1.00 78.71  ?  250 ASP   A CB     1 
ATOM   986  C  CG     . ASP   A 1 139 ? 137.448 109.735 -15.088 1.00 91.37  ?  250 ASP   A CG     1 
ATOM   987  O  OD1    . ASP   A 1 139 ? 136.230 109.527 -14.864 1.00 91.55  ?  250 ASP   A OD1    1 
ATOM   988  O  OD2    . ASP   A 1 139 ? 137.898 110.842 -15.462 1.00 97.90  -1 250 ASP   A OD2    1 
ATOM   989  N  N      . THR   A 1 140 ? 137.514 105.959 -12.688 1.00 71.31  ?  251 THR   A N      1 
ATOM   990  C  CA     . THR   A 1 140 ? 137.227 104.531 -12.574 1.00 70.06  ?  251 THR   A CA     1 
ATOM   991  C  C      . THR   A 1 140 ? 135.726 104.275 -12.655 1.00 70.46  ?  251 THR   A C      1 
ATOM   992  O  O      . THR   A 1 140 ? 134.922 105.164 -12.368 1.00 69.40  ?  251 THR   A O      1 
ATOM   993  C  CB     . THR   A 1 140 ? 137.756 103.979 -11.239 1.00 81.38  ?  251 THR   A CB     1 
ATOM   994  O  OG1    . THR   A 1 140 ? 138.879 104.746 -10.801 1.00 85.37  ?  251 THR   A OG1    1 
ATOM   995  C  CG2    . THR   A 1 140 ? 138.105 102.498 -11.314 1.00 80.68  ?  251 THR   A CG2    1 
ATOM   996  N  N      . ALA   A 1 141 ? 135.357 103.047 -13.018 1.00 65.81  ?  252 ALA   A N      1 
ATOM   997  C  CA     . ALA   A 1 141 ? 133.971 102.609 -13.040 1.00 65.20  ?  252 ALA   A CA     1 
ATOM   998  C  C      . ALA   A 1 141 ? 133.524 102.406 -11.586 1.00 68.84  ?  252 ALA   A C      1 
ATOM   999  O  O      . ALA   A 1 141 ? 132.426 102.814 -11.231 1.00 68.63  ?  252 ALA   A O      1 
ATOM   1000 C  CB     . ALA   A 1 141 ? 133.855 101.307 -13.802 1.00 65.76  ?  252 ALA   A CB     1 
ATOM   1001 N  N      . HIS   A 1 142 ? 134.404 101.829 -10.740 1.00 65.15  ?  253 HIS   A N      1 
ATOM   1002 C  CA     . HIS   A 1 142 ? 134.129 101.530 -9.337  1.00 64.32  ?  253 HIS   A CA     1 
ATOM   1003 C  C      . HIS   A 1 142 ? 135.232 102.071 -8.421  1.00 69.38  ?  253 HIS   A C      1 
ATOM   1004 O  O      . HIS   A 1 142 ? 136.268 101.430 -8.222  1.00 69.33  ?  253 HIS   A O      1 
ATOM   1005 C  CB     . HIS   A 1 142 ? 133.895 100.017 -9.167  1.00 64.42  ?  253 HIS   A CB     1 
ATOM   1006 C  CG     . HIS   A 1 142 ? 133.525 99.570  -7.786  1.00 67.32  ?  253 HIS   A CG     1 
ATOM   1007 N  ND1    . HIS   A 1 142 ? 132.748 100.351 -6.948  1.00 68.82  ?  253 HIS   A ND1    1 
ATOM   1008 C  CD2    . HIS   A 1 142 ? 133.790 98.396  -7.167  1.00 68.47  ?  253 HIS   A CD2    1 
ATOM   1009 C  CE1    . HIS   A 1 142 ? 132.591 99.642  -5.842  1.00 67.95  ?  253 HIS   A CE1    1 
ATOM   1010 N  NE2    . HIS   A 1 142 ? 133.198 98.458  -5.929  1.00 68.24  ?  253 HIS   A NE2    1 
ATOM   1011 N  N      . GLY   A 1 143 ? 134.985 103.266 -7.894  1.00 66.89  ?  254 GLY   A N      1 
ATOM   1012 C  CA     . GLY   A 1 143 ? 135.882 103.992 -7.002  1.00 67.54  ?  254 GLY   A CA     1 
ATOM   1013 C  C      . GLY   A 1 143 ? 136.087 103.360 -5.637  1.00 72.74  ?  254 GLY   A C      1 
ATOM   1014 O  O      . GLY   A 1 143 ? 137.110 103.619 -4.998  1.00 72.25  ?  254 GLY   A O      1 
ATOM   1015 N  N      . HIS   A 1 144 ? 135.140 102.514 -5.177  1.00 69.63  ?  255 HIS   A N      1 
ATOM   1016 C  CA     . HIS   A 1 144 ? 135.243 101.838 -3.876  1.00 69.97  ?  255 HIS   A CA     1 
ATOM   1017 C  C      . HIS   A 1 144 ? 136.025 100.497 -3.944  1.00 74.15  ?  255 HIS   A C      1 
ATOM   1018 O  O      . HIS   A 1 144 ? 135.718 99.550  -3.214  1.00 73.53  ?  255 HIS   A O      1 
ATOM   1019 C  CB     . HIS   A 1 144 ? 133.855 101.673 -3.223  1.00 71.02  ?  255 HIS   A CB     1 
ATOM   1020 C  CG     . HIS   A 1 144 ? 133.889 101.485 -1.734  1.00 74.65  ?  255 HIS   A CG     1 
ATOM   1021 N  ND1    . HIS   A 1 144 ? 132.783 101.027 -1.047  1.00 76.46  ?  255 HIS   A ND1    1 
ATOM   1022 C  CD2    . HIS   A 1 144 ? 134.894 101.699 -0.851  1.00 76.76  ?  255 HIS   A CD2    1 
ATOM   1023 C  CE1    . HIS   A 1 144 ? 133.143 100.985 0.225   1.00 76.17  ?  255 HIS   A CE1    1 
ATOM   1024 N  NE2    . HIS   A 1 144 ? 134.408 101.370 0.389   1.00 76.61  ?  255 HIS   A NE2    1 
ATOM   1025 N  N      A SER   A 1 145 ? 137.052 100.458 -4.806  0.69 71.42  ?  256 SER   A N      1 
ATOM   1026 N  N      B SER   A 1 145 ? 137.036 100.429 -4.823  0.31 70.99  ?  256 SER   A N      1 
ATOM   1027 C  CA     A SER   A 1 145 ? 137.941 99.323  -5.044  0.69 71.44  ?  256 SER   A CA     1 
ATOM   1028 C  CA     B SER   A 1 145 ? 137.884 99.249  -4.967  0.31 70.88  ?  256 SER   A CA     1 
ATOM   1029 C  C      A SER   A 1 145 ? 139.266 99.514  -4.295  0.69 75.26  ?  256 SER   A C      1 
ATOM   1030 C  C      B SER   A 1 145 ? 139.248 99.488  -4.316  0.31 75.04  ?  256 SER   A C      1 
ATOM   1031 O  O      A SER   A 1 145 ? 139.684 100.656 -4.074  0.69 74.61  ?  256 SER   A O      1 
ATOM   1032 O  O      B SER   A 1 145 ? 139.659 100.640 -4.149  0.31 74.51  ?  256 SER   A O      1 
ATOM   1033 C  CB     A SER   A 1 145 ? 138.209 99.187  -6.542  0.69 75.02  ?  256 SER   A CB     1 
ATOM   1034 C  CB     B SER   A 1 145 ? 138.019 98.839  -6.430  0.31 74.10  ?  256 SER   A CB     1 
ATOM   1035 O  OG     A SER   A 1 145 ? 139.189 98.204  -6.834  0.69 85.71  ?  256 SER   A OG     1 
ATOM   1036 O  OG     B SER   A 1 145 ? 138.582 99.873  -7.216  0.31 82.10  ?  256 SER   A OG     1 
ATOM   1037 N  N      . LYS   A 1 146 ? 139.929 98.395  -3.923  1.00 71.94  ?  257 LYS   A N      1 
ATOM   1038 C  CA     . LYS   A 1 146 ? 141.237 98.411  -3.241  1.00 72.15  ?  257 LYS   A CA     1 
ATOM   1039 C  C      . LYS   A 1 146 ? 142.310 99.103  -4.089  1.00 75.89  ?  257 LYS   A C      1 
ATOM   1040 O  O      . LYS   A 1 146 ? 143.021 99.961  -3.572  1.00 75.30  ?  257 LYS   A O      1 
ATOM   1041 C  CB     . LYS   A 1 146 ? 141.672 96.987  -2.832  1.00 75.06  ?  257 LYS   A CB     1 
ATOM   1042 C  CG     . LYS   A 1 146 ? 142.888 96.920  -1.896  1.00 93.27  ?  257 LYS   A CG     1 
ATOM   1043 C  CD     . LYS   A 1 146 ? 142.522 97.076  -0.414  1.00 106.68 ?  257 LYS   A CD     1 
ATOM   1044 C  CE     . LYS   A 1 146 ? 142.806 98.457  0.144   1.00 120.01 ?  257 LYS   A CE     1 
ATOM   1045 N  NZ     . LYS   A 1 146 ? 144.250 98.662  0.435   1.00 128.62 1  257 LYS   A NZ     1 
ATOM   1046 N  N      . GLY   A 1 147 ? 142.332 98.791  -5.386  1.00 73.40  ?  258 GLY   A N      1 
ATOM   1047 C  CA     . GLY   A 1 147 ? 143.251 99.367  -6.364  1.00 73.69  ?  258 GLY   A CA     1 
ATOM   1048 C  C      . GLY   A 1 147 ? 143.149 100.872 -6.498  1.00 78.73  ?  258 GLY   A C      1 
ATOM   1049 O  O      . GLY   A 1 147 ? 144.156 101.539 -6.744  1.00 78.21  ?  258 GLY   A O      1 
ATOM   1050 N  N      . VAL   A 1 148 ? 141.930 101.419 -6.323  1.00 76.71  ?  259 VAL   A N      1 
ATOM   1051 C  CA     . VAL   A 1 148 ? 141.670 102.861 -6.386  1.00 77.05  ?  259 VAL   A CA     1 
ATOM   1052 C  C      . VAL   A 1 148 ? 142.169 103.525 -5.100  1.00 82.60  ?  259 VAL   A C      1 
ATOM   1053 O  O      . VAL   A 1 148 ? 142.897 104.517 -5.182  1.00 82.14  ?  259 VAL   A O      1 
ATOM   1054 C  CB     . VAL   A 1 148 ? 140.187 103.200 -6.723  1.00 80.58  ?  259 VAL   A CB     1 
ATOM   1055 C  CG1    . VAL   A 1 148 ? 139.913 104.702 -6.633  1.00 80.16  ?  259 VAL   A CG1    1 
ATOM   1056 C  CG2    . VAL   A 1 148 ? 139.815 102.687 -8.109  1.00 80.29  ?  259 VAL   A CG2    1 
ATOM   1057 N  N      . ILE   A 1 149 ? 141.804 102.956 -3.924  1.00 80.43  ?  260 ILE   A N      1 
ATOM   1058 C  CA     . ILE   A 1 149 ? 142.196 103.448 -2.594  1.00 80.81  ?  260 ILE   A CA     1 
ATOM   1059 C  C      . ILE   A 1 149 ? 143.716 103.641 -2.513  1.00 85.19  ?  260 ILE   A C      1 
ATOM   1060 O  O      . ILE   A 1 149 ? 144.174 104.734 -2.166  1.00 84.12  ?  260 ILE   A O      1 
ATOM   1061 C  CB     . ILE   A 1 149 ? 141.617 102.548 -1.458  1.00 84.11  ?  260 ILE   A CB     1 
ATOM   1062 C  CG1    . ILE   A 1 149 ? 140.075 102.693 -1.379  1.00 84.65  ?  260 ILE   A CG1    1 
ATOM   1063 C  CG2    . ILE   A 1 149 ? 142.274 102.854 -0.093  1.00 84.71  ?  260 ILE   A CG2    1 
ATOM   1064 C  CD1    . ILE   A 1 149 ? 139.314 101.488 -0.780  1.00 93.49  ?  260 ILE   A CD1    1 
ATOM   1065 N  N      . ASP   A 1 150 ? 144.480 102.596 -2.898  1.00 83.16  ?  261 ASP   A N      1 
ATOM   1066 C  CA     . ASP   A 1 150 ? 145.946 102.598 -2.920  1.00 83.55  ?  261 ASP   A CA     1 
ATOM   1067 C  C      . ASP   A 1 150 ? 146.481 103.673 -3.870  1.00 88.52  ?  261 ASP   A C      1 
ATOM   1068 O  O      . ASP   A 1 150 ? 147.371 104.435 -3.485  1.00 88.27  ?  261 ASP   A O      1 
ATOM   1069 C  CB     . ASP   A 1 150 ? 146.493 101.209 -3.314  1.00 85.34  ?  261 ASP   A CB     1 
ATOM   1070 C  CG     . ASP   A 1 150 ? 146.024 100.044 -2.457  1.00 92.57  ?  261 ASP   A CG     1 
ATOM   1071 O  OD1    . ASP   A 1 150 ? 145.906 100.218 -1.222  1.00 92.06  ?  261 ASP   A OD1    1 
ATOM   1072 O  OD2    . ASP   A 1 150 ? 145.811 98.948  -3.016  1.00 99.12  -1 261 ASP   A OD2    1 
ATOM   1073 N  N      . GLN   A 1 151 ? 145.907 103.760 -5.088  1.00 85.93  ?  262 GLN   A N      1 
ATOM   1074 C  CA     . GLN   A 1 151 ? 146.295 104.746 -6.099  1.00 86.26  ?  262 GLN   A CA     1 
ATOM   1075 C  C      . GLN   A 1 151 ? 146.033 106.193 -5.668  1.00 90.82  ?  262 GLN   A C      1 
ATOM   1076 O  O      . GLN   A 1 151 ? 146.828 107.065 -6.007  1.00 89.99  ?  262 GLN   A O      1 
ATOM   1077 C  CB     . GLN   A 1 151 ? 145.650 104.438 -7.457  1.00 87.70  ?  262 GLN   A CB     1 
ATOM   1078 C  CG     . GLN   A 1 151 ? 146.643 104.426 -8.622  1.00 105.02 ?  262 GLN   A CG     1 
ATOM   1079 C  CD     . GLN   A 1 151 ? 147.614 103.267 -8.564  1.00 121.62 ?  262 GLN   A CD     1 
ATOM   1080 O  OE1    . GLN   A 1 151 ? 148.729 103.383 -8.046  1.00 115.47 ?  262 GLN   A OE1    1 
ATOM   1081 N  NE2    . GLN   A 1 151 ? 147.209 102.122 -9.089  1.00 113.89 ?  262 GLN   A NE2    1 
ATOM   1082 N  N      . VAL   A 1 152 ? 144.948 106.439 -4.897  1.00 88.59  ?  263 VAL   A N      1 
ATOM   1083 C  CA     . VAL   A 1 152 ? 144.599 107.762 -4.354  1.00 89.10  ?  263 VAL   A CA     1 
ATOM   1084 C  C      . VAL   A 1 152 ? 145.710 108.207 -3.384  1.00 94.24  ?  263 VAL   A C      1 
ATOM   1085 O  O      . VAL   A 1 152 ? 146.175 109.347 -3.476  1.00 94.14  ?  263 VAL   A O      1 
ATOM   1086 C  CB     . VAL   A 1 152 ? 143.187 107.775 -3.694  1.00 93.25  ?  263 VAL   A CB     1 
ATOM   1087 C  CG1    . VAL   A 1 152 ? 142.928 109.072 -2.929  1.00 93.08  ?  263 VAL   A CG1    1 
ATOM   1088 C  CG2    . VAL   A 1 152 ? 142.090 107.552 -4.730  1.00 93.17  ?  263 VAL   A CG2    1 
ATOM   1089 N  N      . LYS   A 1 153 ? 146.155 107.285 -2.492  1.00 91.13  ?  264 LYS   A N      1 
ATOM   1090 C  CA     . LYS   A 1 153 ? 147.230 107.501 -1.513  1.00 91.11  ?  264 LYS   A CA     1 
ATOM   1091 C  C      . LYS   A 1 153 ? 148.549 107.855 -2.221  1.00 95.73  ?  264 LYS   A C      1 
ATOM   1092 O  O      . LYS   A 1 153 ? 149.206 108.820 -1.832  1.00 95.01  ?  264 LYS   A O      1 
ATOM   1093 C  CB     . LYS   A 1 153 ? 147.441 106.246 -0.639  1.00 93.29  ?  264 LYS   A CB     1 
ATOM   1094 C  CG     . LYS   A 1 153 ? 146.292 105.884 0.292   1.00 102.30 ?  264 LYS   A CG     1 
ATOM   1095 C  CD     . LYS   A 1 153 ? 146.558 104.549 0.970   1.00 109.74 ?  264 LYS   A CD     1 
ATOM   1096 C  CE     . LYS   A 1 153 ? 145.397 104.071 1.803   1.00 119.16 ?  264 LYS   A CE     1 
ATOM   1097 N  NZ     . LYS   A 1 153 ? 145.645 102.715 2.358   1.00 126.44 1  264 LYS   A NZ     1 
ATOM   1098 N  N      . HIS   A 1 154 ? 148.913 107.076 -3.266  1.00 93.30  ?  265 HIS   A N      1 
ATOM   1099 C  CA     . HIS   A 1 154 ? 150.137 107.228 -4.059  1.00 93.55  ?  265 HIS   A CA     1 
ATOM   1100 C  C      . HIS   A 1 154 ? 150.230 108.572 -4.789  1.00 97.08  ?  265 HIS   A C      1 
ATOM   1101 O  O      . HIS   A 1 154 ? 151.285 109.203 -4.719  1.00 96.76  ?  265 HIS   A O      1 
ATOM   1102 C  CB     . HIS   A 1 154 ? 150.318 106.040 -5.030  1.00 94.63  ?  265 HIS   A CB     1 
ATOM   1103 C  CG     . HIS   A 1 154 ? 151.380 106.238 -6.074  1.00 98.31  ?  265 HIS   A CG     1 
ATOM   1104 N  ND1    . HIS   A 1 154 ? 152.727 106.256 -5.745  1.00 100.21 ?  265 HIS   A ND1    1 
ATOM   1105 C  CD2    . HIS   A 1 154 ? 151.256 106.404 -7.412  1.00 100.17 ?  265 HIS   A CD2    1 
ATOM   1106 C  CE1    . HIS   A 1 154 ? 153.372 106.443 -6.886  1.00 99.61  ?  265 HIS   A CE1    1 
ATOM   1107 N  NE2    . HIS   A 1 154 ? 152.530 106.537 -7.916  1.00 99.98  ?  265 HIS   A NE2    1 
ATOM   1108 N  N      . ILE   A 1 155 ? 149.150 109.004 -5.488  1.00 93.51  ?  266 ILE   A N      1 
ATOM   1109 C  CA     . ILE   A 1 155 ? 149.125 110.273 -6.236  1.00 93.21  ?  266 ILE   A CA     1 
ATOM   1110 C  C      . ILE   A 1 155 ? 149.343 111.464 -5.297  1.00 97.77  ?  266 ILE   A C      1 
ATOM   1111 O  O      . ILE   A 1 155 ? 150.162 112.331 -5.599  1.00 97.77  ?  266 ILE   A O      1 
ATOM   1112 C  CB     . ILE   A 1 155 ? 147.864 110.444 -7.152  1.00 95.98  ?  266 ILE   A CB     1 
ATOM   1113 C  CG1    . ILE   A 1 155 ? 147.636 109.237 -8.121  1.00 96.23  ?  266 ILE   A CG1    1 
ATOM   1114 C  CG2    . ILE   A 1 155 ? 147.878 111.778 -7.923  1.00 96.28  ?  266 ILE   A CG2    1 
ATOM   1115 C  CD1    . ILE   A 1 155 ? 148.792 108.829 -9.116  1.00 103.51 ?  266 ILE   A CD1    1 
ATOM   1116 N  N      . LYS   A 1 156 ? 148.645 111.480 -4.149  1.00 94.61  ?  267 LYS   A N      1 
ATOM   1117 C  CA     . LYS   A 1 156 ? 148.767 112.546 -3.154  1.00 94.55  ?  267 LYS   A CA     1 
ATOM   1118 C  C      . LYS   A 1 156 ? 150.128 112.529 -2.428  1.00 99.30  ?  267 LYS   A C      1 
ATOM   1119 O  O      . LYS   A 1 156 ? 150.572 113.574 -1.951  1.00 98.68  ?  267 LYS   A O      1 
ATOM   1120 C  CB     . LYS   A 1 156 ? 147.580 112.519 -2.171  1.00 96.82  ?  267 LYS   A CB     1 
ATOM   1121 C  CG     . LYS   A 1 156 ? 147.171 113.895 -1.637  1.00 109.06 ?  267 LYS   A CG     1 
ATOM   1122 C  CD     . LYS   A 1 156 ? 146.456 114.757 -2.683  1.00 117.74 ?  267 LYS   A CD     1 
ATOM   1123 C  CE     . LYS   A 1 156 ? 146.381 116.204 -2.269  1.00 126.51 ?  267 LYS   A CE     1 
ATOM   1124 N  NZ     . LYS   A 1 156 ? 145.990 117.077 -3.404  1.00 134.15 1  267 LYS   A NZ     1 
ATOM   1125 N  N      . LYS   A 1 157 ? 150.795 111.356 -2.365  1.00 96.67  ?  268 LYS   A N      1 
ATOM   1126 C  CA     . LYS   A 1 157 ? 152.114 111.225 -1.736  1.00 96.70  ?  268 LYS   A CA     1 
ATOM   1127 C  C      . LYS   A 1 157 ? 153.228 111.654 -2.705  1.00 100.55 ?  268 LYS   A C      1 
ATOM   1128 O  O      . LYS   A 1 157 ? 154.257 112.169 -2.265  1.00 100.13 ?  268 LYS   A O      1 
ATOM   1129 C  CB     . LYS   A 1 157 ? 152.344 109.798 -1.211  1.00 99.36  ?  268 LYS   A CB     1 
ATOM   1130 C  CG     . LYS   A 1 157 ? 153.344 109.730 -0.062  1.00 115.84 ?  268 LYS   A CG     1 
ATOM   1131 C  CD     . LYS   A 1 157 ? 153.375 108.354 0.591   1.00 127.57 ?  268 LYS   A CD     1 
ATOM   1132 C  CE     . LYS   A 1 157 ? 154.415 108.248 1.683   1.00 140.08 ?  268 LYS   A CE     1 
ATOM   1133 N  NZ     . LYS   A 1 157 ? 154.053 109.039 2.892   1.00 149.35 1  268 LYS   A NZ     1 
ATOM   1134 N  N      . THR   A 1 158 ? 153.008 111.460 -4.020  1.00 97.12  ?  269 THR   A N      1 
ATOM   1135 C  CA     . THR   A 1 158 ? 153.953 111.835 -5.072  1.00 96.95  ?  269 THR   A CA     1 
ATOM   1136 C  C      . THR   A 1 158 ? 153.797 113.325 -5.419  1.00 101.54 ?  269 THR   A C      1 
ATOM   1137 O  O      . THR   A 1 158 ? 154.786 114.058 -5.383  1.00 101.64 ?  269 THR   A O      1 
ATOM   1138 C  CB     . THR   A 1 158 ? 153.821 110.895 -6.286  1.00 103.94 ?  269 THR   A CB     1 
ATOM   1139 O  OG1    . THR   A 1 158 ? 153.766 109.542 -5.834  1.00 102.35 ?  269 THR   A OG1    1 
ATOM   1140 C  CG2    . THR   A 1 158 ? 154.970 111.046 -7.276  1.00 103.36 ?  269 THR   A CG2    1 
ATOM   1141 N  N      . TYR   A 1 159 ? 152.563 113.772 -5.733  1.00 98.02  ?  270 TYR   A N      1 
ATOM   1142 C  CA     . TYR   A 1 159 ? 152.272 115.164 -6.098  1.00 97.67  ?  270 TYR   A CA     1 
ATOM   1143 C  C      . TYR   A 1 159 ? 151.224 115.780 -5.143  1.00 100.87 ?  270 TYR   A C      1 
ATOM   1144 O  O      . TYR   A 1 159 ? 150.053 115.896 -5.524  1.00 100.70 ?  270 TYR   A O      1 
ATOM   1145 C  CB     . TYR   A 1 159 ? 151.821 115.291 -7.578  1.00 98.92  ?  270 TYR   A CB     1 
ATOM   1146 C  CG     . TYR   A 1 159 ? 152.357 114.228 -8.515  1.00 100.83 ?  270 TYR   A CG     1 
ATOM   1147 C  CD1    . TYR   A 1 159 ? 153.566 114.403 -9.182  1.00 102.75 ?  270 TYR   A CD1    1 
ATOM   1148 C  CD2    . TYR   A 1 159 ? 151.636 113.064 -8.764  1.00 101.69 ?  270 TYR   A CD2    1 
ATOM   1149 C  CE1    . TYR   A 1 159 ? 154.059 113.430 -10.052 1.00 103.51 ?  270 TYR   A CE1    1 
ATOM   1150 C  CE2    . TYR   A 1 159 ? 152.125 112.078 -9.621  1.00 102.71 ?  270 TYR   A CE2    1 
ATOM   1151 C  CZ     . TYR   A 1 159 ? 153.333 112.270 -10.271 1.00 110.19 ?  270 TYR   A CZ     1 
ATOM   1152 O  OH     . TYR   A 1 159 ? 153.810 111.300 -11.122 1.00 111.04 ?  270 TYR   A OH     1 
ATOM   1153 N  N      . PRO   A 1 160 ? 151.603 116.193 -3.904  1.00 96.62  ?  271 PRO   A N      1 
ATOM   1154 C  CA     . PRO   A 1 160 ? 150.599 116.781 -2.992  1.00 96.13  ?  271 PRO   A CA     1 
ATOM   1155 C  C      . PRO   A 1 160 ? 150.102 118.169 -3.402  1.00 99.11  ?  271 PRO   A C      1 
ATOM   1156 O  O      . PRO   A 1 160 ? 149.044 118.590 -2.942  1.00 98.65  ?  271 PRO   A O      1 
ATOM   1157 C  CB     . PRO   A 1 160 ? 151.313 116.806 -1.638  1.00 97.92  ?  271 PRO   A CB     1 
ATOM   1158 C  CG     . PRO   A 1 160 ? 152.751 116.859 -1.970  1.00 102.44 ?  271 PRO   A CG     1 
ATOM   1159 C  CD     . PRO   A 1 160 ? 152.938 116.134 -3.272  1.00 98.04  ?  271 PRO   A CD     1 
ATOM   1160 N  N      . GLU   A 1 161 ? 150.857 118.866 -4.270  1.00 95.34  ?  272 GLU   A N      1 
ATOM   1161 C  CA     . GLU   A 1 161 ? 150.530 120.204 -4.769  1.00 94.97  ?  272 GLU   A CA     1 
ATOM   1162 C  C      . GLU   A 1 161 ? 149.389 120.227 -5.798  1.00 97.40  ?  272 GLU   A C      1 
ATOM   1163 O  O      . GLU   A 1 161 ? 148.801 121.288 -6.024  1.00 96.79  ?  272 GLU   A O      1 
ATOM   1164 C  CB     . GLU   A 1 161 ? 151.789 120.896 -5.324  1.00 96.43  ?  272 GLU   A CB     1 
ATOM   1165 C  CG     . GLU   A 1 161 ? 152.626 121.584 -4.258  1.00 108.57 ?  272 GLU   A CG     1 
ATOM   1166 C  CD     . GLU   A 1 161 ? 152.032 122.872 -3.719  1.00 131.00 ?  272 GLU   A CD     1 
ATOM   1167 O  OE1    . GLU   A 1 161 ? 152.241 123.933 -4.351  1.00 125.86 ?  272 GLU   A OE1    1 
ATOM   1168 O  OE2    . GLU   A 1 161 ? 151.348 122.819 -2.671  1.00 124.90 -1 272 GLU   A OE2    1 
ATOM   1169 N  N      . ILE   A 1 162 ? 149.076 119.070 -6.416  1.00 93.04  ?  273 ILE   A N      1 
ATOM   1170 C  CA     . ILE   A 1 162 ? 148.009 118.962 -7.419  1.00 92.33  ?  273 ILE   A CA     1 
ATOM   1171 C  C      . ILE   A 1 162 ? 146.716 118.429 -6.794  1.00 93.91  ?  273 ILE   A C      1 
ATOM   1172 O  O      . ILE   A 1 162 ? 146.745 117.420 -6.083  1.00 93.63  ?  273 ILE   A O      1 
ATOM   1173 C  CB     . ILE   A 1 162 ? 148.459 118.156 -8.684  1.00 95.59  ?  273 ILE   A CB     1 
ATOM   1174 C  CG1    . ILE   A 1 162 ? 149.760 118.734 -9.326  1.00 96.10  ?  273 ILE   A CG1    1 
ATOM   1175 C  CG2    . ILE   A 1 162 ? 147.329 117.998 -9.729  1.00 96.51  ?  273 ILE   A CG2    1 
ATOM   1176 C  CD1    . ILE   A 1 162 ? 149.737 120.249 -9.844  1.00 104.32 ?  273 ILE   A CD1    1 
ATOM   1177 N  N      . THR   A 1 163 ? 145.591 119.125 -7.061  1.00 88.66  ?  274 THR   A N      1 
ATOM   1178 C  CA     . THR   A 1 163 ? 144.249 118.767 -6.594  1.00 87.49  ?  274 THR   A CA     1 
ATOM   1179 C  C      . THR   A 1 163 ? 143.869 117.392 -7.154  1.00 88.30  ?  274 THR   A C      1 
ATOM   1180 O  O      . THR   A 1 163 ? 143.999 117.157 -8.357  1.00 87.72  ?  274 THR   A O      1 
ATOM   1181 C  CB     . THR   A 1 163 ? 143.240 119.865 -6.977  1.00 95.40  ?  274 THR   A CB     1 
ATOM   1182 O  OG1    . THR   A 1 163 ? 143.603 121.082 -6.324  1.00 97.18  ?  274 THR   A OG1    1 
ATOM   1183 C  CG2    . THR   A 1 163 ? 141.810 119.506 -6.610  1.00 92.85  ?  274 THR   A CG2    1 
ATOM   1184 N  N      . LEU   A 1 164 ? 143.446 116.480 -6.268  1.00 82.05  ?  275 LEU   A N      1 
ATOM   1185 C  CA     . LEU   A 1 164 ? 143.062 115.133 -6.654  1.00 80.49  ?  275 LEU   A CA     1 
ATOM   1186 C  C      . LEU   A 1 164 ? 141.549 114.909 -6.563  1.00 81.74  ?  275 LEU   A C      1 
ATOM   1187 O  O      . LEU   A 1 164 ? 140.936 115.186 -5.529  1.00 81.23  ?  275 LEU   A O      1 
ATOM   1188 C  CB     . LEU   A 1 164 ? 143.844 114.088 -5.831  1.00 80.47  ?  275 LEU   A CB     1 
ATOM   1189 C  CG     . LEU   A 1 164 ? 143.682 112.614 -6.240  1.00 85.21  ?  275 LEU   A CG     1 
ATOM   1190 C  CD1    . LEU   A 1 164 ? 144.190 112.357 -7.658  1.00 85.34  ?  275 LEU   A CD1    1 
ATOM   1191 C  CD2    . LEU   A 1 164 ? 144.377 111.696 -5.257  1.00 87.36  ?  275 LEU   A CD2    1 
ATOM   1192 N  N      . VAL   A 1 165 ? 140.959 114.427 -7.671  1.00 75.64  ?  276 VAL   A N      1 
ATOM   1193 C  CA     . VAL   A 1 165 ? 139.544 114.070 -7.792  1.00 73.87  ?  276 VAL   A CA     1 
ATOM   1194 C  C      . VAL   A 1 165 ? 139.534 112.554 -7.930  1.00 75.89  ?  276 VAL   A C      1 
ATOM   1195 O  O      . VAL   A 1 165 ? 140.295 112.009 -8.738  1.00 75.76  ?  276 VAL   A O      1 
ATOM   1196 C  CB     . VAL   A 1 165 ? 138.819 114.771 -8.983  1.00 77.15  ?  276 VAL   A CB     1 
ATOM   1197 C  CG1    . VAL   A 1 165 ? 137.407 114.221 -9.188  1.00 76.73  ?  276 VAL   A CG1    1 
ATOM   1198 C  CG2    . VAL   A 1 165 ? 138.766 116.276 -8.788  1.00 76.80  ?  276 VAL   A CG2    1 
ATOM   1199 N  N      . ALA   A 1 166 ? 138.699 111.875 -7.127  1.00 70.59  ?  277 ALA   A N      1 
ATOM   1200 C  CA     . ALA   A 1 166 ? 138.598 110.417 -7.153  1.00 69.43  ?  277 ALA   A CA     1 
ATOM   1201 C  C      . ALA   A 1 166 ? 137.153 109.942 -7.262  1.00 70.93  ?  277 ALA   A C      1 
ATOM   1202 O  O      . ALA   A 1 166 ? 136.249 110.557 -6.698  1.00 70.88  ?  277 ALA   A O      1 
ATOM   1203 C  CB     . ALA   A 1 166 ? 139.265 109.825 -5.923  1.00 70.07  ?  277 ALA   A CB     1 
ATOM   1204 N  N      . GLY   A 1 167 ? 136.956 108.856 -7.998  1.00 65.38  ?  278 GLY   A N      1 
ATOM   1205 C  CA     . GLY   A 1 167 ? 135.643 108.264 -8.214  1.00 64.35  ?  278 GLY   A CA     1 
ATOM   1206 C  C      . GLY   A 1 167 ? 135.654 107.096 -9.181  1.00 65.48  ?  278 GLY   A C      1 
ATOM   1207 O  O      . GLY   A 1 167 ? 136.727 106.643 -9.579  1.00 65.62  ?  278 GLY   A O      1 
ATOM   1208 N  N      . ASN   A 1 168 ? 134.475 106.578 -9.572  1.00 59.13  ?  279 ASN   A N      1 
ATOM   1209 C  CA     . ASN   A 1 168 ? 133.153 107.045 -9.151  1.00 57.41  ?  279 ASN   A CA     1 
ATOM   1210 C  C      . ASN   A 1 168 ? 132.586 106.251 -7.972  1.00 58.46  ?  279 ASN   A C      1 
ATOM   1211 O  O      . ASN   A 1 168 ? 132.855 105.059 -7.850  1.00 57.88  ?  279 ASN   A O      1 
ATOM   1212 C  CB     . ASN   A 1 168 ? 132.184 107.017 -10.330 1.00 55.13  ?  279 ASN   A CB     1 
ATOM   1213 C  CG     . ASN   A 1 168 ? 132.324 108.172 -11.292 1.00 72.66  ?  279 ASN   A CG     1 
ATOM   1214 O  OD1    . ASN   A 1 168 ? 133.381 108.811 -11.414 1.00 67.27  ?  279 ASN   A OD1    1 
ATOM   1215 N  ND2    . ASN   A 1 168 ? 131.261 108.441 -12.032 1.00 61.24  ?  279 ASN   A ND2    1 
ATOM   1216 N  N      . VAL   A 1 169 ? 131.806 106.917 -7.106  1.00 53.31  ?  280 VAL   A N      1 
ATOM   1217 C  CA     . VAL   A 1 169 ? 131.165 106.305 -5.929  1.00 52.99  ?  280 VAL   A CA     1 
ATOM   1218 C  C      . VAL   A 1 169 ? 129.673 106.670 -5.852  1.00 54.52  ?  280 VAL   A C      1 
ATOM   1219 O  O      . VAL   A 1 169 ? 129.235 107.559 -6.581  1.00 53.60  ?  280 VAL   A O      1 
ATOM   1220 C  CB     . VAL   A 1 169 ? 131.899 106.639 -4.601  1.00 56.85  ?  280 VAL   A CB     1 
ATOM   1221 C  CG1    . VAL   A 1 169 ? 133.367 106.234 -4.656  1.00 56.86  ?  280 VAL   A CG1    1 
ATOM   1222 C  CG2    . VAL   A 1 169 ? 131.746 108.106 -4.229  1.00 56.40  ?  280 VAL   A CG2    1 
ATOM   1223 N  N      . ALA   A 1 170 ? 128.909 106.020 -4.947  1.00 51.08  ?  281 ALA   A N      1 
ATOM   1224 C  CA     . ALA   A 1 170 ? 127.466 106.282 -4.793  1.00 51.50  ?  281 ALA   A CA     1 
ATOM   1225 C  C      . ALA   A 1 170 ? 126.920 106.110 -3.356  1.00 57.66  ?  281 ALA   A C      1 
ATOM   1226 O  O      . ALA   A 1 170 ? 125.695 106.117 -3.150  1.00 57.99  ?  281 ALA   A O      1 
ATOM   1227 C  CB     . ALA   A 1 170 ? 126.671 105.428 -5.771  1.00 51.82  ?  281 ALA   A CB     1 
ATOM   1228 N  N      . THR   A 1 171 ? 127.822 105.979 -2.366  1.00 54.46  ?  282 THR   A N      1 
ATOM   1229 C  CA     . THR   A 1 171 ? 127.465 105.806 -0.950  1.00 54.21  ?  282 THR   A CA     1 
ATOM   1230 C  C      . THR   A 1 171 ? 128.303 106.745 -0.056  1.00 60.47  ?  282 THR   A C      1 
ATOM   1231 O  O      . THR   A 1 171 ? 129.337 107.259 -0.499  1.00 59.40  ?  282 THR   A O      1 
ATOM   1232 C  CB     . THR   A 1 171 ? 127.703 104.344 -0.520  1.00 56.87  ?  282 THR   A CB     1 
ATOM   1233 O  OG1    . THR   A 1 171 ? 129.079 104.033 -0.708  1.00 60.88  ?  282 THR   A OG1    1 
ATOM   1234 C  CG2    . THR   A 1 171 ? 126.851 103.345 -1.276  1.00 53.85  ?  282 THR   A CG2    1 
ATOM   1235 N  N      . ALA   A 1 172 ? 127.884 106.923 1.216   1.00 58.59  ?  283 ALA   A N      1 
ATOM   1236 C  CA     . ALA   A 1 172 ? 128.618 107.734 2.188   1.00 59.01  ?  283 ALA   A CA     1 
ATOM   1237 C  C      . ALA   A 1 172 ? 129.930 107.025 2.570   1.00 63.93  ?  283 ALA   A C      1 
ATOM   1238 O  O      . ALA   A 1 172 ? 130.978 107.675 2.586   1.00 63.70  ?  283 ALA   A O      1 
ATOM   1239 C  CB     . ALA   A 1 172 ? 127.768 107.984 3.426   1.00 59.76  ?  283 ALA   A CB     1 
ATOM   1240 N  N      . GLU   A 1 173 ? 129.879 105.686 2.797   1.00 60.69  ?  284 GLU   A N      1 
ATOM   1241 C  CA     . GLU   A 1 173 ? 131.039 104.850 3.137   1.00 60.98  ?  284 GLU   A CA     1 
ATOM   1242 C  C      . GLU   A 1 173 ? 132.162 104.962 2.098   1.00 66.10  ?  284 GLU   A C      1 
ATOM   1243 O  O      . GLU   A 1 173 ? 133.326 105.127 2.472   1.00 65.75  ?  284 GLU   A O      1 
ATOM   1244 C  CB     . GLU   A 1 173 ? 130.629 103.381 3.358   1.00 62.35  ?  284 GLU   A CB     1 
ATOM   1245 C  CG     . GLU   A 1 173 ? 131.728 102.542 3.997   1.00 74.15  ?  284 GLU   A CG     1 
ATOM   1246 C  CD     . GLU   A 1 173 ? 131.334 101.141 4.420   1.00 98.94  ?  284 GLU   A CD     1 
ATOM   1247 O  OE1    . GLU   A 1 173 ? 130.488 101.010 5.335   1.00 95.98  ?  284 GLU   A OE1    1 
ATOM   1248 O  OE2    . GLU   A 1 173 ? 131.909 100.172 3.873   1.00 94.18  -1 284 GLU   A OE2    1 
ATOM   1249 N  N      . ALA   A 1 174 ? 131.809 104.906 0.805   1.00 63.30  ?  285 ALA   A N      1 
ATOM   1250 C  CA     . ALA   A 1 174 ? 132.768 105.026 -0.287  1.00 63.58  ?  285 ALA   A CA     1 
ATOM   1251 C  C      . ALA   A 1 174 ? 133.341 106.435 -0.371  1.00 68.24  ?  285 ALA   A C      1 
ATOM   1252 O  O      . ALA   A 1 174 ? 134.518 106.587 -0.689  1.00 68.57  ?  285 ALA   A O      1 
ATOM   1253 C  CB     . ALA   A 1 174 ? 132.117 104.640 -1.598  1.00 64.42  ?  285 ALA   A CB     1 
ATOM   1254 N  N      . THR   A 1 175 ? 132.523 107.457 -0.043  1.00 65.52  ?  286 THR   A N      1 
ATOM   1255 C  CA     . THR   A 1 175 ? 132.904 108.875 -0.035  1.00 65.77  ?  286 THR   A CA     1 
ATOM   1256 C  C      . THR   A 1 175 ? 133.866 109.165 1.128   1.00 71.10  ?  286 THR   A C      1 
ATOM   1257 O  O      . THR   A 1 175 ? 134.793 109.967 0.976   1.00 70.43  ?  286 THR   A O      1 
ATOM   1258 C  CB     . THR   A 1 175 ? 131.636 109.737 -0.029  1.00 73.59  ?  286 THR   A CB     1 
ATOM   1259 O  OG1    . THR   A 1 175 ? 130.894 109.434 -1.208  1.00 75.82  ?  286 THR   A OG1    1 
ATOM   1260 C  CG2    . THR   A 1 175 ? 131.923 111.234 0.020   1.00 71.24  ?  286 THR   A CG2    1 
ATOM   1261 N  N      . LYS   A 1 176 ? 133.641 108.489 2.278   1.00 68.61  ?  287 LYS   A N      1 
ATOM   1262 C  CA     . LYS   A 1 176 ? 134.436 108.572 3.503   1.00 68.66  ?  287 LYS   A CA     1 
ATOM   1263 C  C      . LYS   A 1 176 ? 135.841 108.057 3.219   1.00 72.45  ?  287 LYS   A C      1 
ATOM   1264 O  O      . LYS   A 1 176 ? 136.810 108.788 3.420   1.00 71.25  ?  287 LYS   A O      1 
ATOM   1265 C  CB     . LYS   A 1 176 ? 133.773 107.727 4.611   1.00 71.66  ?  287 LYS   A CB     1 
ATOM   1266 C  CG     . LYS   A 1 176 ? 134.379 107.881 6.004   1.00 86.16  ?  287 LYS   A CG     1 
ATOM   1267 C  CD     . LYS   A 1 176 ? 133.961 106.722 6.914   1.00 95.67  ?  287 LYS   A CD     1 
ATOM   1268 C  CE     . LYS   A 1 176 ? 133.621 107.159 8.321   1.00 107.74 ?  287 LYS   A CE     1 
ATOM   1269 N  NZ     . LYS   A 1 176 ? 134.831 107.501 9.117   1.00 117.26 1  287 LYS   A NZ     1 
ATOM   1270 N  N      . ASP   A 1 177 ? 135.930 106.808 2.713   1.00 70.10  ?  288 ASP   A N      1 
ATOM   1271 C  CA     . ASP   A 1 177 ? 137.164 106.098 2.382   1.00 70.47  ?  288 ASP   A CA     1 
ATOM   1272 C  C      . ASP   A 1 177 ? 138.074 106.856 1.427   1.00 75.55  ?  288 ASP   A C      1 
ATOM   1273 O  O      . ASP   A 1 177 ? 139.258 106.985 1.726   1.00 76.11  ?  288 ASP   A O      1 
ATOM   1274 C  CB     . ASP   A 1 177 ? 136.860 104.685 1.862   1.00 72.19  ?  288 ASP   A CB     1 
ATOM   1275 C  CG     . ASP   A 1 177 ? 136.523 103.681 2.953   1.00 81.86  ?  288 ASP   A CG     1 
ATOM   1276 O  OD1    . ASP   A 1 177 ? 136.723 102.466 2.725   1.00 82.08  ?  288 ASP   A OD1    1 
ATOM   1277 O  OD2    . ASP   A 1 177 ? 136.071 104.111 4.045   1.00 87.69  -1 288 ASP   A OD2    1 
ATOM   1278 N  N      . LEU   A 1 178 ? 137.533 107.384 0.315   1.00 72.43  ?  289 LEU   A N      1 
ATOM   1279 C  CA     . LEU   A 1 178 ? 138.325 108.138 -0.659  1.00 72.42  ?  289 LEU   A CA     1 
ATOM   1280 C  C      . LEU   A 1 178 ? 138.890 109.427 -0.082  1.00 77.13  ?  289 LEU   A C      1 
ATOM   1281 O  O      . LEU   A 1 178 ? 140.051 109.748 -0.347  1.00 76.55  ?  289 LEU   A O      1 
ATOM   1282 C  CB     . LEU   A 1 178 ? 137.554 108.413 -1.959  1.00 72.28  ?  289 LEU   A CB     1 
ATOM   1283 C  CG     . LEU   A 1 178 ? 137.132 107.219 -2.824  1.00 76.51  ?  289 LEU   A CG     1 
ATOM   1284 C  CD1    . LEU   A 1 178 ? 136.600 107.701 -4.147  1.00 76.46  ?  289 LEU   A CD1    1 
ATOM   1285 C  CD2    . LEU   A 1 178 ? 138.285 106.248 -3.071  1.00 77.94  ?  289 LEU   A CD2    1 
ATOM   1286 N  N      . PHE   A 1 179 ? 138.089 110.141 0.740   1.00 74.43  ?  290 PHE   A N      1 
ATOM   1287 C  CA     . PHE   A 1 179 ? 138.524 111.372 1.406   1.00 74.60  ?  290 PHE   A CA     1 
ATOM   1288 C  C      . PHE   A 1 179 ? 139.605 111.067 2.449   1.00 80.05  ?  290 PHE   A C      1 
ATOM   1289 O  O      . PHE   A 1 179 ? 140.529 111.866 2.623   1.00 80.10  ?  290 PHE   A O      1 
ATOM   1290 C  CB     . PHE   A 1 179 ? 137.340 112.114 2.050   1.00 76.04  ?  290 PHE   A CB     1 
ATOM   1291 C  CG     . PHE   A 1 179 ? 136.452 112.926 1.131   1.00 77.11  ?  290 PHE   A CG     1 
ATOM   1292 C  CD1    . PHE   A 1 179 ? 135.137 113.209 1.481   1.00 79.64  ?  290 PHE   A CD1    1 
ATOM   1293 C  CD2    . PHE   A 1 179 ? 136.938 113.432 -0.072  1.00 78.76  ?  290 PHE   A CD2    1 
ATOM   1294 C  CE1    . PHE   A 1 179 ? 134.322 113.976 0.643   1.00 80.32  ?  290 PHE   A CE1    1 
ATOM   1295 C  CE2    . PHE   A 1 179 ? 136.124 114.208 -0.902  1.00 81.38  ?  290 PHE   A CE2    1 
ATOM   1296 C  CZ     . PHE   A 1 179 ? 134.815 114.457 -0.549  1.00 79.32  ?  290 PHE   A CZ     1 
ATOM   1297 N  N      . GLU   A 1 180 ? 139.493 109.897 3.114   1.00 77.11  ?  291 GLU   A N      1 
ATOM   1298 C  CA     . GLU   A 1 180 ? 140.451 109.407 4.108   1.00 77.19  ?  291 GLU   A CA     1 
ATOM   1299 C  C      . GLU   A 1 180 ? 141.742 108.931 3.431   1.00 81.83  ?  291 GLU   A C      1 
ATOM   1300 O  O      . GLU   A 1 180 ? 142.806 109.014 4.042   1.00 82.01  ?  291 GLU   A O      1 
ATOM   1301 C  CB     . GLU   A 1 180 ? 139.845 108.262 4.934   1.00 78.39  ?  291 GLU   A CB     1 
ATOM   1302 C  CG     . GLU   A 1 180 ? 138.949 108.723 6.072   1.00 87.39  ?  291 GLU   A CG     1 
ATOM   1303 C  CD     . GLU   A 1 180 ? 138.342 107.636 6.945   1.00 102.38 ?  291 GLU   A CD     1 
ATOM   1304 O  OE1    . GLU   A 1 180 ? 138.624 106.438 6.712   1.00 94.66  ?  291 GLU   A OE1    1 
ATOM   1305 O  OE2    . GLU   A 1 180 ? 137.577 107.992 7.870   1.00 92.60  -1 291 GLU   A OE2    1 
ATOM   1306 N  N      . ALA   A 1 181 ? 141.645 108.420 2.185   1.00 77.80  ?  292 ALA   A N      1 
ATOM   1307 C  CA     . ALA   A 1 181 ? 142.796 107.929 1.421   1.00 77.18  ?  292 ALA   A CA     1 
ATOM   1308 C  C      . ALA   A 1 181 ? 143.660 109.063 0.854   1.00 80.58  ?  292 ALA   A C      1 
ATOM   1309 O  O      . ALA   A 1 181 ? 144.863 108.872 0.677   1.00 80.44  ?  292 ALA   A O      1 
ATOM   1310 C  CB     . ALA   A 1 181 ? 142.340 106.999 0.307   1.00 77.91  ?  292 ALA   A CB     1 
ATOM   1311 N  N      . GLY   A 1 182 ? 143.049 110.219 0.579   1.00 76.31  ?  293 GLY   A N      1 
ATOM   1312 C  CA     . GLY   A 1 182 ? 143.764 111.381 0.062   1.00 75.87  ?  293 GLY   A CA     1 
ATOM   1313 C  C      . GLY   A 1 182 ? 143.076 112.204 -1.014  1.00 79.13  ?  293 GLY   A C      1 
ATOM   1314 O  O      . GLY   A 1 182 ? 143.699 113.117 -1.566  1.00 79.06  ?  293 GLY   A O      1 
ATOM   1315 N  N      . ALA   A 1 183 ? 141.795 111.914 -1.320  1.00 74.22  ?  294 ALA   A N      1 
ATOM   1316 C  CA     . ALA   A 1 183 ? 141.059 112.674 -2.336  1.00 73.10  ?  294 ALA   A CA     1 
ATOM   1317 C  C      . ALA   A 1 183 ? 140.581 114.020 -1.800  1.00 75.68  ?  294 ALA   A C      1 
ATOM   1318 O  O      . ALA   A 1 183 ? 140.178 114.124 -0.638  1.00 74.97  ?  294 ALA   A O      1 
ATOM   1319 C  CB     . ALA   A 1 183 ? 139.880 111.871 -2.861  1.00 73.58  ?  294 ALA   A CB     1 
ATOM   1320 N  N      . ASP   A 1 184 ? 140.654 115.054 -2.646  1.00 71.70  ?  295 ASP   A N      1 
ATOM   1321 C  CA     . ASP   A 1 184 ? 140.195 116.403 -2.308  1.00 71.39  ?  295 ASP   A CA     1 
ATOM   1322 C  C      . ASP   A 1 184 ? 138.717 116.506 -2.682  1.00 73.69  ?  295 ASP   A C      1 
ATOM   1323 O  O      . ASP   A 1 184 ? 137.927 117.077 -1.930  1.00 74.08  ?  295 ASP   A O      1 
ATOM   1324 C  CB     . ASP   A 1 184 ? 141.008 117.478 -3.063  1.00 73.29  ?  295 ASP   A CB     1 
ATOM   1325 C  CG     . ASP   A 1 184 ? 142.497 117.448 -2.786  1.00 82.25  ?  295 ASP   A CG     1 
ATOM   1326 O  OD1    . ASP   A 1 184 ? 143.214 116.702 -3.487  1.00 81.94  ?  295 ASP   A OD1    1 
ATOM   1327 O  OD2    . ASP   A 1 184 ? 142.945 118.173 -1.872  1.00 88.95  -1 295 ASP   A OD2    1 
ATOM   1328 N  N      . ILE   A 1 185 ? 138.358 115.959 -3.860  1.00 67.79  ?  296 ILE   A N      1 
ATOM   1329 C  CA     . ILE   A 1 185 ? 137.011 115.966 -4.417  1.00 66.39  ?  296 ILE   A CA     1 
ATOM   1330 C  C      . ILE   A 1 185 ? 136.593 114.533 -4.767  1.00 67.98  ?  296 ILE   A C      1 
ATOM   1331 O  O      . ILE   A 1 185 ? 137.376 113.794 -5.364  1.00 67.63  ?  296 ILE   A O      1 
ATOM   1332 C  CB     . ILE   A 1 185 ? 136.911 116.934 -5.638  1.00 69.43  ?  296 ILE   A CB     1 
ATOM   1333 C  CG1    . ILE   A 1 185 ? 137.408 118.357 -5.290  1.00 70.00  ?  296 ILE   A CG1    1 
ATOM   1334 C  CG2    . ILE   A 1 185 ? 135.484 116.991 -6.184  1.00 70.18  ?  296 ILE   A CG2    1 
ATOM   1335 C  CD1    . ILE   A 1 185 ? 138.048 119.118 -6.429  1.00 78.36  ?  296 ILE   A CD1    1 
ATOM   1336 N  N      . VAL   A 1 186 ? 135.364 114.143 -4.383  1.00 62.70  ?  297 VAL   A N      1 
ATOM   1337 C  CA     . VAL   A 1 186 ? 134.805 112.820 -4.675  1.00 61.24  ?  297 VAL   A CA     1 
ATOM   1338 C  C      . VAL   A 1 186 ? 133.764 112.934 -5.797  1.00 61.45  ?  297 VAL   A C      1 
ATOM   1339 O  O      . VAL   A 1 186 ? 132.911 113.822 -5.751  1.00 61.61  ?  297 VAL   A O      1 
ATOM   1340 C  CB     . VAL   A 1 186 ? 134.310 112.093 -3.394  1.00 64.87  ?  297 VAL   A CB     1 
ATOM   1341 C  CG1    . VAL   A 1 186 ? 133.115 111.188 -3.661  1.00 64.65  ?  297 VAL   A CG1    1 
ATOM   1342 C  CG2    . VAL   A 1 186 ? 135.441 111.292 -2.767  1.00 64.54  ?  297 VAL   A CG2    1 
ATOM   1343 N  N      . LYS   A 1 187 ? 133.888 112.073 -6.830  1.00 55.29  ?  298 LYS   A N      1 
ATOM   1344 C  CA     . LYS   A 1 187 ? 133.019 112.036 -8.010  1.00 53.98  ?  298 LYS   A CA     1 
ATOM   1345 C  C      . LYS   A 1 187 ? 131.874 111.038 -7.787  1.00 56.83  ?  298 LYS   A C      1 
ATOM   1346 O  O      . LYS   A 1 187 ? 132.111 109.837 -7.621  1.00 55.68  ?  298 LYS   A O      1 
ATOM   1347 C  CB     . LYS   A 1 187 ? 133.842 111.714 -9.268  1.00 56.00  ?  298 LYS   A CB     1 
ATOM   1348 C  CG     . LYS   A 1 187 ? 133.135 112.019 -10.588 1.00 66.20  ?  298 LYS   A CG     1 
ATOM   1349 C  CD     . LYS   A 1 187 ? 134.020 112.796 -11.571 1.00 71.36  ?  298 LYS   A CD     1 
ATOM   1350 C  CE     . LYS   A 1 187 ? 134.800 111.934 -12.528 1.00 74.35  ?  298 LYS   A CE     1 
ATOM   1351 N  NZ     . LYS   A 1 187 ? 133.972 111.490 -13.672 1.00 72.17  1  298 LYS   A NZ     1 
ATOM   1352 N  N      . VAL   A 1 188 ? 130.633 111.553 -7.769  1.00 52.82  ?  299 VAL   A N      1 
ATOM   1353 C  CA     . VAL   A 1 188 ? 129.418 110.772 -7.495  1.00 52.65  ?  299 VAL   A CA     1 
ATOM   1354 C  C      . VAL   A 1 188 ? 128.654 110.407 -8.750  1.00 55.59  ?  299 VAL   A C      1 
ATOM   1355 O  O      . VAL   A 1 188 ? 128.177 111.292 -9.468  1.00 56.25  ?  299 VAL   A O      1 
ATOM   1356 C  CB     . VAL   A 1 188 ? 128.505 111.487 -6.460  1.00 57.04  ?  299 VAL   A CB     1 
ATOM   1357 C  CG1    . VAL   A 1 188 ? 127.282 110.638 -6.105  1.00 57.05  ?  299 VAL   A CG1    1 
ATOM   1358 C  CG2    . VAL   A 1 188 ? 129.289 111.863 -5.206  1.00 56.89  ?  299 VAL   A CG2    1 
ATOM   1359 N  N      . GLY   A 1 189 ? 128.481 109.108 -8.957  1.00 51.20  ?  300 GLY   A N      1 
ATOM   1360 C  CA     . GLY   A 1 189 ? 127.727 108.585 -10.089 1.00 50.58  ?  300 GLY   A CA     1 
ATOM   1361 C  C      . GLY   A 1 189 ? 128.035 107.144 -10.433 1.00 54.23  ?  300 GLY   A C      1 
ATOM   1362 O  O      . GLY   A 1 189 ? 129.071 106.867 -11.039 1.00 53.21  ?  300 GLY   A O      1 
ATOM   1363 N  N      . ILE   A 1 190 ? 127.122 106.219 -10.062 1.00 50.52  ?  301 ILE   A N      1 
ATOM   1364 C  CA     . ILE   A 1 190 ? 127.191 104.800 -10.388 1.00 51.14  ?  301 ILE   A CA     1 
ATOM   1365 C  C      . ILE   A 1 190 ? 125.871 104.456 -11.093 1.00 56.27  ?  301 ILE   A C      1 
ATOM   1366 O  O      . ILE   A 1 190 ? 124.818 104.387 -10.452 1.00 55.50  ?  301 ILE   A O      1 
ATOM   1367 C  CB     . ILE   A 1 190 ? 127.482 103.889 -9.151  1.00 54.67  ?  301 ILE   A CB     1 
ATOM   1368 C  CG1    . ILE   A 1 190 ? 128.853 104.182 -8.500  1.00 55.10  ?  301 ILE   A CG1    1 
ATOM   1369 C  CG2    . ILE   A 1 190 ? 127.320 102.397 -9.471  1.00 55.94  ?  301 ILE   A CG2    1 
ATOM   1370 C  CD1    . ILE   A 1 190 ? 130.083 103.947 -9.358  1.00 62.96  ?  301 ILE   A CD1    1 
ATOM   1371 N  N      . GLY   A 1 191 ? 125.944 104.363 -12.420 1.00 53.31  ?  302 GLY   A N      1 
ATOM   1372 C  CA     . GLY   A 1 191 ? 124.827 104.037 -13.296 1.00 52.90  ?  302 GLY   A CA     1 
ATOM   1373 C  C      . GLY   A 1 191 ? 123.862 105.110 -13.788 1.00 55.95  ?  302 GLY   A C      1 
ATOM   1374 O  O      . GLY   A 1 191 ? 122.890 104.724 -14.443 1.00 56.43  ?  302 GLY   A O      1 
ATOM   1375 N  N      . PRO   A 1 192 ? 124.005 106.440 -13.539 1.00 52.36  ?  303 PRO   A N      1 
ATOM   1376 C  CA     . PRO   A 1 192 ? 122.975 107.372 -14.039 1.00 52.50  ?  303 PRO   A CA     1 
ATOM   1377 C  C      . PRO   A 1 192 ? 123.134 107.884 -15.480 1.00 57.22  ?  303 PRO   A C      1 
ATOM   1378 O  O      . PRO   A 1 192 ? 122.147 108.349 -16.056 1.00 57.41  ?  303 PRO   A O      1 
ATOM   1379 C  CB     . PRO   A 1 192 ? 123.036 108.519 -13.041 1.00 54.17  ?  303 PRO   A CB     1 
ATOM   1380 C  CG     . PRO   A 1 192 ? 124.474 108.550 -12.602 1.00 58.39  ?  303 PRO   A CG     1 
ATOM   1381 C  CD     . PRO   A 1 192 ? 125.047 107.173 -12.779 1.00 53.83  ?  303 PRO   A CD     1 
ATOM   1382 N  N      . GLY   A 1 193 ? 124.349 107.797 -16.033 1.00 52.88  ?  304 GLY   A N      1 
ATOM   1383 C  CA     . GLY   A 1 193 ? 124.705 108.266 -17.372 1.00 52.59  ?  304 GLY   A CA     1 
ATOM   1384 C  C      . GLY   A 1 193 ? 123.774 107.856 -18.496 1.00 56.46  ?  304 GLY   A C      1 
ATOM   1385 O  O      . GLY   A 1 193 ? 123.313 106.717 -18.527 1.00 56.49  ?  304 GLY   A O      1 
ATOM   1386 N  N      . SER   A 1 194 ? 123.465 108.795 -19.414 1.00 54.06  ?  305 SER   A N      1 
ATOM   1387 C  CA     . SER   A 1 194 ? 122.591 108.553 -20.577 1.00 54.32  ?  305 SER   A CA     1 
ATOM   1388 C  C      . SER   A 1 194 ? 123.052 107.346 -21.423 1.00 59.37  ?  305 SER   A C      1 
ATOM   1389 O  O      . SER   A 1 194 ? 122.230 106.516 -21.824 1.00 58.81  ?  305 SER   A O      1 
ATOM   1390 C  CB     . SER   A 1 194 ? 122.527 109.799 -21.453 1.00 57.61  ?  305 SER   A CB     1 
ATOM   1391 O  OG     . SER   A 1 194 ? 123.818 110.162 -21.916 1.00 64.87  ?  305 SER   A OG     1 
ATOM   1392 N  N      . ILE   A 1 195 ? 124.375 107.247 -21.658 1.00 57.27  ?  306 ILE   A N      1 
ATOM   1393 C  CA     . ILE   A 1 195 ? 125.024 106.187 -22.444 1.00 57.43  ?  306 ILE   A CA     1 
ATOM   1394 C  C      . ILE   A 1 195 ? 125.431 104.968 -21.606 1.00 64.52  ?  306 ILE   A C      1 
ATOM   1395 O  O      . ILE   A 1 195 ? 126.092 104.059 -22.121 1.00 65.02  ?  306 ILE   A O      1 
ATOM   1396 C  CB     . ILE   A 1 195 ? 126.229 106.746 -23.254 1.00 59.71  ?  306 ILE   A CB     1 
ATOM   1397 C  CG1    . ILE   A 1 195 ? 127.071 107.787 -22.455 1.00 59.26  ?  306 ILE   A CG1    1 
ATOM   1398 C  CG2    . ILE   A 1 195 ? 125.767 107.301 -24.596 1.00 59.96  ?  306 ILE   A CG2    1 
ATOM   1399 C  CD1    . ILE   A 1 195 ? 127.896 107.274 -21.261 1.00 64.64  ?  306 ILE   A CD1    1 
ATOM   1400 N  N      . CYS   A 1 196 ? 125.060 104.959 -20.320 1.00 62.57  ?  307 CYS   A N      1 
ATOM   1401 C  CA     . CYS   A 1 196 ? 125.391 103.884 -19.381 1.00 63.33  ?  307 CYS   A CA     1 
ATOM   1402 C  C      . CYS   A 1 196 ? 124.397 102.714 -19.447 1.00 65.38  ?  307 CYS   A C      1 
ATOM   1403 O  O      . CYS   A 1 196 ? 123.183 102.931 -19.496 1.00 65.56  ?  307 CYS   A O      1 
ATOM   1404 C  CB     . CYS   A 1 196 ? 125.487 104.445 -17.964 1.00 64.42  ?  307 CYS   A CB     1 
ATOM   1405 S  SG     . CYS   A 1 196 ? 125.537 103.186 -16.662 1.00 68.50  ?  307 CYS   A SG     1 
ATOM   1406 H  HA     . CYS   A 1 196 ? 126.378 103.493 -19.625 1.00 63.52  ?  307 CYS   A HA     1 
ATOM   1407 N  N      . THR   A 1 197 ? 124.930 101.470 -19.401 1.00 59.52  ?  308 THR   A N      1 
ATOM   1408 C  CA     . THR   A 1 197 ? 124.159 100.221 -19.368 1.00 57.84  ?  308 THR   A CA     1 
ATOM   1409 C  C      . THR   A 1 197 ? 124.571 99.361  -18.155 1.00 58.51  ?  308 THR   A C      1 
ATOM   1410 O  O      . THR   A 1 197 ? 124.232 98.186  -18.113 1.00 58.23  ?  308 THR   A O      1 
ATOM   1411 C  CB     . THR   A 1 197 ? 124.245 99.441  -20.701 1.00 66.83  ?  308 THR   A CB     1 
ATOM   1412 O  OG1    . THR   A 1 197 ? 125.606 99.175  -21.012 1.00 67.03  ?  308 THR   A OG1    1 
ATOM   1413 C  CG2    . THR   A 1 197 ? 123.564 100.152 -21.859 1.00 68.35  ?  308 THR   A CG2    1 
ATOM   1414 N  N      . THR   A 1 198 ? 125.285 99.944  -17.167 1.00 53.62  ?  309 THR   A N      1 
ATOM   1415 C  CA     . THR   A 1 198 ? 125.732 99.259  -15.939 1.00 52.61  ?  309 THR   A CA     1 
ATOM   1416 C  C      . THR   A 1 198 ? 124.536 98.715  -15.149 1.00 54.80  ?  309 THR   A C      1 
ATOM   1417 O  O      . THR   A 1 198 ? 124.651 97.667  -14.513 1.00 54.24  ?  309 THR   A O      1 
ATOM   1418 C  CB     . THR   A 1 198 ? 126.588 100.196 -15.085 1.00 60.09  ?  309 THR   A CB     1 
ATOM   1419 O  OG1    . THR   A 1 198 ? 127.685 100.674 -15.864 1.00 65.13  ?  309 THR   A OG1    1 
ATOM   1420 C  CG2    . THR   A 1 198 ? 127.101 99.543  -13.805 1.00 56.51  ?  309 THR   A CG2    1 
ATOM   1421 N  N      . ARG   A 1 199 ? 123.392 99.429  -15.195 1.00 50.19  ?  310 ARG   A N      1 
ATOM   1422 C  CA     . ARG   A 1 199 ? 122.165 99.017  -14.518 1.00 49.54  ?  310 ARG   A CA     1 
ATOM   1423 C  C      . ARG   A 1 199 ? 121.639 97.723  -15.134 1.00 53.35  ?  310 ARG   A C      1 
ATOM   1424 O  O      . ARG   A 1 199 ? 121.246 96.827  -14.399 1.00 54.29  ?  310 ARG   A O      1 
ATOM   1425 C  CB     . ARG   A 1 199 ? 121.085 100.125 -14.583 1.00 49.03  ?  310 ARG   A CB     1 
ATOM   1426 C  CG     . ARG   A 1 199 ? 121.332 101.339 -13.686 1.00 49.20  ?  310 ARG   A CG     1 
ATOM   1427 C  CD     . ARG   A 1 199 ? 120.134 102.283 -13.670 1.00 57.35  ?  310 ARG   A CD     1 
ATOM   1428 N  NE     . ARG   A 1 199 ? 120.439 103.560 -13.009 1.00 68.11  ?  310 ARG   A NE     1 
ATOM   1429 C  CZ     . ARG   A 1 199 ? 119.531 104.459 -12.629 1.00 80.19  ?  310 ARG   A CZ     1 
ATOM   1430 N  NH1    . ARG   A 1 199 ? 119.911 105.590 -12.051 1.00 65.92  1  310 ARG   A NH1    1 
ATOM   1431 N  NH2    . ARG   A 1 199 ? 118.238 104.232 -12.821 1.00 66.36  ?  310 ARG   A NH2    1 
ATOM   1432 N  N      A VAL   A 1 200 ? 121.675 97.639  -16.468 0.63 49.63  ?  311 VAL   A N      1 
ATOM   1433 N  N      B VAL   A 1 200 ? 121.634 97.602  -16.482 0.37 49.53  ?  311 VAL   A N      1 
ATOM   1434 C  CA     A VAL   A 1 200 ? 121.178 96.532  -17.285 0.63 49.22  ?  311 VAL   A CA     1 
ATOM   1435 C  CA     B VAL   A 1 200 ? 121.119 96.390  -17.148 0.37 49.10  ?  311 VAL   A CA     1 
ATOM   1436 C  C      A VAL   A 1 200 ? 122.166 95.347  -17.324 0.63 52.96  ?  311 VAL   A C      1 
ATOM   1437 C  C      B VAL   A 1 200 ? 122.182 95.281  -17.276 0.37 53.10  ?  311 VAL   A C      1 
ATOM   1438 O  O      A VAL   A 1 200 ? 121.740 94.194  -17.258 0.63 51.67  ?  311 VAL   A O      1 
ATOM   1439 O  O      B VAL   A 1 200 ? 121.818 94.105  -17.240 0.37 52.19  ?  311 VAL   A O      1 
ATOM   1440 C  CB     A VAL   A 1 200 ? 120.829 97.043  -18.715 0.63 52.91  ?  311 VAL   A CB     1 
ATOM   1441 C  CB     B VAL   A 1 200 ? 120.394 96.638  -18.501 0.37 52.69  ?  311 VAL   A CB     1 
ATOM   1442 C  CG1    A VAL   A 1 200 ? 119.993 96.030  -19.474 0.63 52.52  ?  311 VAL   A CG1    1 
ATOM   1443 C  CG1    B VAL   A 1 200 ? 119.048 97.320  -18.291 0.37 52.39  ?  311 VAL   A CG1    1 
ATOM   1444 C  CG2    A VAL   A 1 200 ? 120.108 98.393  -18.675 0.63 52.77  ?  311 VAL   A CG2    1 
ATOM   1445 C  CG2    B VAL   A 1 200 ? 121.262 97.415  -19.489 0.37 52.50  ?  311 VAL   A CG2    1 
ATOM   1446 N  N      . VAL   A 1 201 ? 123.471 95.642  -17.434 1.00 50.31  ?  312 VAL   A N      1 
ATOM   1447 C  CA     . VAL   A 1 201 ? 124.553 94.659  -17.541 1.00 51.43  ?  312 VAL   A CA     1 
ATOM   1448 C  C      . VAL   A 1 201 ? 124.983 94.123  -16.154 1.00 56.44  ?  312 VAL   A C      1 
ATOM   1449 O  O      . VAL   A 1 201 ? 125.086 92.912  -15.981 1.00 56.01  ?  312 VAL   A O      1 
ATOM   1450 C  CB     . VAL   A 1 201 ? 125.745 95.211  -18.386 1.00 56.19  ?  312 VAL   A CB     1 
ATOM   1451 C  CG1    . VAL   A 1 201 ? 126.948 94.264  -18.373 1.00 56.40  ?  312 VAL   A CG1    1 
ATOM   1452 C  CG2    . VAL   A 1 201 ? 125.311 95.500  -19.826 1.00 55.82  ?  312 VAL   A CG2    1 
ATOM   1453 N  N      . ALA   A 1 202 ? 125.207 95.009  -15.171 1.00 53.48  ?  313 ALA   A N      1 
ATOM   1454 C  CA     . ALA   A 1 202 ? 125.678 94.588  -13.845 1.00 52.67  ?  313 ALA   A CA     1 
ATOM   1455 C  C      . ALA   A 1 202 ? 124.603 94.546  -12.734 1.00 54.02  ?  313 ALA   A C      1 
ATOM   1456 O  O      . ALA   A 1 202 ? 124.893 94.060  -11.647 1.00 53.01  ?  313 ALA   A O      1 
ATOM   1457 C  CB     . ALA   A 1 202 ? 126.855 95.465  -13.419 1.00 53.26  ?  313 ALA   A CB     1 
ATOM   1458 N  N      . GLY   A 1 203 ? 123.401 95.064  -13.006 1.00 50.74  ?  314 GLY   A N      1 
ATOM   1459 C  CA     . GLY   A 1 203 ? 122.284 95.108  -12.057 1.00 49.74  ?  314 GLY   A CA     1 
ATOM   1460 C  C      . GLY   A 1 203 ? 122.539 96.010  -10.867 1.00 51.87  ?  314 GLY   A C      1 
ATOM   1461 O  O      . GLY   A 1 203 ? 121.871 95.899  -9.837  1.00 51.60  ?  314 GLY   A O      1 
ATOM   1462 N  N      . VAL   A 1 204 ? 123.522 96.902  -11.023 1.00 46.94  ?  315 VAL   A N      1 
ATOM   1463 C  CA     . VAL   A 1 204 ? 124.070 97.814  -10.034 1.00 45.81  ?  315 VAL   A CA     1 
ATOM   1464 C  C      . VAL   A 1 204 ? 123.783 99.263  -10.412 1.00 51.17  ?  315 VAL   A C      1 
ATOM   1465 O  O      . VAL   A 1 204 ? 123.794 99.630  -11.595 1.00 50.41  ?  315 VAL   A O      1 
ATOM   1466 C  CB     . VAL   A 1 204 ? 125.604 97.537  -9.895  1.00 48.33  ?  315 VAL   A CB     1 
ATOM   1467 C  CG1    . VAL   A 1 204 ? 126.363 98.709  -9.279  1.00 47.52  ?  315 VAL   A CG1    1 
ATOM   1468 C  CG2    . VAL   A 1 204 ? 125.868 96.249  -9.106  1.00 48.01  ?  315 VAL   A CG2    1 
ATOM   1469 N  N      . GLY   A 1 205 ? 123.598 100.077 -9.383  1.00 47.57  ?  316 GLY   A N      1 
ATOM   1470 C  CA     . GLY   A 1 205 ? 123.366 101.504 -9.521  1.00 46.80  ?  316 GLY   A CA     1 
ATOM   1471 C  C      . GLY   A 1 205 ? 122.648 102.061 -8.323  1.00 49.77  ?  316 GLY   A C      1 
ATOM   1472 O  O      . GLY   A 1 205 ? 122.003 101.319 -7.569  1.00 48.49  ?  316 GLY   A O      1 
ATOM   1473 N  N      . VAL   A 1 206 ? 122.778 103.376 -8.138  1.00 46.23  ?  317 VAL   A N      1 
ATOM   1474 C  CA     . VAL   A 1 206 ? 122.103 104.122 -7.082  1.00 45.51  ?  317 VAL   A CA     1 
ATOM   1475 C  C      . VAL   A 1 206 ? 121.514 105.379 -7.738  1.00 50.31  ?  317 VAL   A C      1 
ATOM   1476 O  O      . VAL   A 1 206 ? 122.289 106.218 -8.221  1.00 51.89  ?  317 VAL   A O      1 
ATOM   1477 C  CB     . VAL   A 1 206 ? 123.003 104.448 -5.849  1.00 49.19  ?  317 VAL   A CB     1 
ATOM   1478 C  CG1    . VAL   A 1 206 ? 122.278 105.372 -4.872  1.00 49.51  ?  317 VAL   A CG1    1 
ATOM   1479 C  CG2    . VAL   A 1 206 ? 123.452 103.174 -5.128  1.00 48.53  ?  317 VAL   A CG2    1 
ATOM   1480 N  N      . PRO   A 1 207 ? 120.162 105.502 -7.802  1.00 44.89  ?  318 PRO   A N      1 
ATOM   1481 C  CA     . PRO   A 1 207 ? 119.540 106.694 -8.405  1.00 45.00  ?  318 PRO   A CA     1 
ATOM   1482 C  C      . PRO   A 1 207 ? 120.196 107.986 -7.935  1.00 50.78  ?  318 PRO   A C      1 
ATOM   1483 O  O      . PRO   A 1 207 ? 120.332 108.219 -6.735  1.00 51.55  ?  318 PRO   A O      1 
ATOM   1484 C  CB     . PRO   A 1 207 ? 118.076 106.553 -8.004  1.00 46.44  ?  318 PRO   A CB     1 
ATOM   1485 C  CG     . PRO   A 1 207 ? 117.875 105.102 -7.921  1.00 50.03  ?  318 PRO   A CG     1 
ATOM   1486 C  CD     . PRO   A 1 207 ? 119.130 104.559 -7.325  1.00 45.60  ?  318 PRO   A CD     1 
ATOM   1487 N  N      . GLN   A 1 208 ? 120.720 108.748 -8.908  1.00 47.02  ?  319 GLN   A N      1 
ATOM   1488 C  CA     . GLN   A 1 208 ? 121.597 109.914 -8.774  1.00 46.67  ?  319 GLN   A CA     1 
ATOM   1489 C  C      . GLN   A 1 208 ? 121.220 110.957 -7.710  1.00 50.40  ?  319 GLN   A C      1 
ATOM   1490 O  O      . GLN   A 1 208 ? 122.128 111.434 -7.032  1.00 51.20  ?  319 GLN   A O      1 
ATOM   1491 C  CB     . GLN   A 1 208 ? 121.807 110.602 -10.130 1.00 47.56  ?  319 GLN   A CB     1 
ATOM   1492 C  CG     . GLN   A 1 208 ? 122.998 111.576 -10.192 1.00 49.92  ?  319 GLN   A CG     1 
ATOM   1493 C  CD     . GLN   A 1 208 ? 124.366 111.011 -9.881  1.00 59.37  ?  319 GLN   A CD     1 
ATOM   1494 O  OE1    . GLN   A 1 208 ? 124.523 109.881 -9.405  1.00 48.58  ?  319 GLN   A OE1    1 
ATOM   1495 N  NE2    . GLN   A 1 208 ? 125.397 111.812 -10.138 1.00 50.56  ?  319 GLN   A NE2    1 
ATOM   1496 N  N      . ILE   A 1 209 ? 119.942 111.319 -7.559  1.00 45.19  ?  320 ILE   A N      1 
ATOM   1497 C  CA     . ILE   A 1 209 ? 119.557 112.311 -6.553  1.00 45.33  ?  320 ILE   A CA     1 
ATOM   1498 C  C      . ILE   A 1 209 ? 119.942 111.824 -5.137  1.00 50.83  ?  320 ILE   A C      1 
ATOM   1499 O  O      . ILE   A 1 209 ? 120.609 112.558 -4.407  1.00 51.64  ?  320 ILE   A O      1 
ATOM   1500 C  CB     . ILE   A 1 209 ? 118.082 112.737 -6.710  1.00 48.21  ?  320 ILE   A CB     1 
ATOM   1501 C  CG1    . ILE   A 1 209 ? 117.909 113.694 -7.914  1.00 48.90  ?  320 ILE   A CG1    1 
ATOM   1502 C  CG2    . ILE   A 1 209 ? 117.486 113.321 -5.418  1.00 47.90  ?  320 ILE   A CG2    1 
ATOM   1503 C  CD1    . ILE   A 1 209 ? 118.427 115.226 -7.747  1.00 53.85  ?  320 ILE   A CD1    1 
ATOM   1504 N  N      . THR   A 1 210 ? 119.599 110.573 -4.799  1.00 47.20  ?  321 THR   A N      1 
ATOM   1505 C  CA     . THR   A 1 210 ? 119.944 109.949 -3.520  1.00 46.74  ?  321 THR   A CA     1 
ATOM   1506 C  C      . THR   A 1 210 ? 121.447 109.746 -3.386  1.00 51.36  ?  321 THR   A C      1 
ATOM   1507 O  O      . THR   A 1 210 ? 121.988 110.001 -2.314  1.00 51.63  ?  321 THR   A O      1 
ATOM   1508 C  CB     . THR   A 1 210 ? 119.132 108.678 -3.315  1.00 48.33  ?  321 THR   A CB     1 
ATOM   1509 O  OG1    . THR   A 1 210 ? 117.770 109.069 -3.193  1.00 49.00  ?  321 THR   A OG1    1 
ATOM   1510 C  CG2    . THR   A 1 210 ? 119.541 107.899 -2.055  1.00 45.88  ?  321 THR   A CG2    1 
ATOM   1511 N  N      . ALA   A 1 211 ? 122.116 109.299 -4.463  1.00 48.36  ?  322 ALA   A N      1 
ATOM   1512 C  CA     . ALA   A 1 211 ? 123.568 109.104 -4.483  1.00 48.63  ?  322 ALA   A CA     1 
ATOM   1513 C  C      . ALA   A 1 211 ? 124.293 110.394 -4.104  1.00 52.15  ?  322 ALA   A C      1 
ATOM   1514 O  O      . ALA   A 1 211 ? 125.176 110.362 -3.248  1.00 51.56  ?  322 ALA   A O      1 
ATOM   1515 C  CB     . ALA   A 1 211 ? 124.018 108.636 -5.862  1.00 49.64  ?  322 ALA   A CB     1 
ATOM   1516 N  N      . ILE   A 1 212 ? 123.900 111.532 -4.722  1.00 48.64  ?  323 ILE   A N      1 
ATOM   1517 C  CA     . ILE   A 1 212 ? 124.475 112.850 -4.450  1.00 48.16  ?  323 ILE   A CA     1 
ATOM   1518 C  C      . ILE   A 1 212 ? 124.227 113.192 -2.978  1.00 53.99  ?  323 ILE   A C      1 
ATOM   1519 O  O      . ILE   A 1 212 ? 125.167 113.594 -2.290  1.00 54.25  ?  323 ILE   A O      1 
ATOM   1520 C  CB     . ILE   A 1 212 ? 123.875 113.939 -5.390  1.00 50.62  ?  323 ILE   A CB     1 
ATOM   1521 C  CG1    . ILE   A 1 212 ? 124.260 113.725 -6.871  1.00 50.48  ?  323 ILE   A CG1    1 
ATOM   1522 C  CG2    . ILE   A 1 212 ? 124.220 115.360 -4.920  1.00 50.38  ?  323 ILE   A CG2    1 
ATOM   1523 C  CD1    . ILE   A 1 212 ? 123.277 114.439 -7.846  1.00 54.56  ?  323 ILE   A CD1    1 
ATOM   1524 N  N      . TYR   A 1 213 ? 122.970 113.006 -2.499  1.00 50.12  ?  324 TYR   A N      1 
ATOM   1525 C  CA     . TYR   A 1 213 ? 122.553 113.315 -1.130  1.00 50.13  ?  324 TYR   A CA     1 
ATOM   1526 C  C      . TYR   A 1 213 ? 123.300 112.510 -0.066  1.00 54.19  ?  324 TYR   A C      1 
ATOM   1527 O  O      . TYR   A 1 213 ? 123.778 113.110 0.888   1.00 54.69  ?  324 TYR   A O      1 
ATOM   1528 C  CB     . TYR   A 1 213 ? 121.024 113.191 -0.955  1.00 51.26  ?  324 TYR   A CB     1 
ATOM   1529 C  CG     . TYR   A 1 213 ? 120.521 113.616 0.414   1.00 51.88  ?  324 TYR   A CG     1 
ATOM   1530 C  CD1    . TYR   A 1 213 ? 120.432 114.962 0.759   1.00 52.84  ?  324 TYR   A CD1    1 
ATOM   1531 C  CD2    . TYR   A 1 213 ? 120.121 112.672 1.356   1.00 52.74  ?  324 TYR   A CD2    1 
ATOM   1532 C  CE1    . TYR   A 1 213 ? 119.969 115.358 2.012   1.00 52.62  ?  324 TYR   A CE1    1 
ATOM   1533 C  CE2    . TYR   A 1 213 ? 119.639 113.056 2.607   1.00 53.55  ?  324 TYR   A CE2    1 
ATOM   1534 C  CZ     . TYR   A 1 213 ? 119.559 114.403 2.928   1.00 60.83  ?  324 TYR   A CZ     1 
ATOM   1535 O  OH     . TYR   A 1 213 ? 119.094 114.793 4.161   1.00 61.98  ?  324 TYR   A OH     1 
ATOM   1536 N  N      . ASP   A 1 214 ? 123.410 111.178 -0.220  1.00 50.11  ?  325 ASP   A N      1 
ATOM   1537 C  CA     . ASP   A 1 214 ? 124.119 110.335 0.750   1.00 49.65  ?  325 ASP   A CA     1 
ATOM   1538 C  C      . ASP   A 1 214 ? 125.613 110.658 0.800   1.00 56.66  ?  325 ASP   A C      1 
ATOM   1539 O  O      . ASP   A 1 214 ? 126.217 110.587 1.869   1.00 56.42  ?  325 ASP   A O      1 
ATOM   1540 C  CB     . ASP   A 1 214 ? 123.937 108.854 0.432   1.00 50.77  ?  325 ASP   A CB     1 
ATOM   1541 C  CG     . ASP   A 1 214 ? 122.513 108.342 0.437   1.00 55.98  ?  325 ASP   A CG     1 
ATOM   1542 O  OD1    . ASP   A 1 214 ? 121.638 109.002 1.054   1.00 55.09  ?  325 ASP   A OD1    1 
ATOM   1543 O  OD2    . ASP   A 1 214 ? 122.276 107.275 -0.150  1.00 57.28  -1 325 ASP   A OD2    1 
ATOM   1544 N  N      . CYS   A 1 215 ? 126.204 110.998 -0.358  1.00 54.74  ?  326 CYS   A N      1 
ATOM   1545 C  CA     . CYS   A 1 215 ? 127.623 111.338 -0.476  1.00 54.78  ?  326 CYS   A CA     1 
ATOM   1546 C  C      . CYS   A 1 215 ? 127.929 112.723 0.077   1.00 59.73  ?  326 CYS   A C      1 
ATOM   1547 O  O      . CYS   A 1 215 ? 128.911 112.877 0.800   1.00 60.00  ?  326 CYS   A O      1 
ATOM   1548 C  CB     . CYS   A 1 215 ? 128.094 111.185 -1.917  1.00 54.80  ?  326 CYS   A CB     1 
ATOM   1549 S  SG     . CYS   A 1 215 ? 128.106 109.473 -2.504  1.00 58.62  ?  326 CYS   A SG     1 
ATOM   1550 N  N      . ALA   A 1 216 ? 127.079 113.717 -0.239  1.00 57.49  ?  327 ALA   A N      1 
ATOM   1551 C  CA     . ALA   A 1 216 ? 127.196 115.088 0.254   1.00 58.37  ?  327 ALA   A CA     1 
ATOM   1552 C  C      . ALA   A 1 216 ? 126.987 115.159 1.766   1.00 65.49  ?  327 ALA   A C      1 
ATOM   1553 O  O      . ALA   A 1 216 ? 127.573 116.032 2.405   1.00 66.28  ?  327 ALA   A O      1 
ATOM   1554 C  CB     . ALA   A 1 216 ? 126.212 115.992 -0.452  1.00 59.19  ?  327 ALA   A CB     1 
ATOM   1555 N  N      . THR   A 1 217 ? 126.176 114.232 2.341   1.00 63.32  ?  328 THR   A N      1 
ATOM   1556 C  CA     . THR   A 1 217 ? 125.954 114.115 3.790   1.00 63.45  ?  328 THR   A CA     1 
ATOM   1557 C  C      . THR   A 1 217 ? 127.302 113.760 4.441   1.00 67.69  ?  328 THR   A C      1 
ATOM   1558 O  O      . THR   A 1 217 ? 127.645 114.331 5.476   1.00 67.72  ?  328 THR   A O      1 
ATOM   1559 C  CB     . THR   A 1 217 ? 124.851 113.075 4.102   1.00 69.14  ?  328 THR   A CB     1 
ATOM   1560 O  OG1    . THR   A 1 217 ? 123.619 113.519 3.533   1.00 69.32  ?  328 THR   A OG1    1 
ATOM   1561 C  CG2    . THR   A 1 217 ? 124.647 112.853 5.607   1.00 65.69  ?  328 THR   A CG2    1 
ATOM   1562 N  N      . GLU   A 1 218 ? 128.076 112.864 3.796   1.00 64.22  ?  329 GLU   A N      1 
ATOM   1563 C  CA     . GLU   A 1 218 ? 129.397 112.461 4.259   1.00 64.49  ?  329 GLU   A CA     1 
ATOM   1564 C  C      . GLU   A 1 218 ? 130.427 113.580 4.074   1.00 68.41  ?  329 GLU   A C      1 
ATOM   1565 O  O      . GLU   A 1 218 ? 131.125 113.892 5.029   1.00 68.27  ?  329 GLU   A O      1 
ATOM   1566 C  CB     . GLU   A 1 218 ? 129.848 111.151 3.592   1.00 66.14  ?  329 GLU   A CB     1 
ATOM   1567 C  CG     . GLU   A 1 218 ? 131.094 110.522 4.209   1.00 79.40  ?  329 GLU   A CG     1 
ATOM   1568 C  CD     . GLU   A 1 218 ? 131.064 110.203 5.695   1.00 100.85 ?  329 GLU   A CD     1 
ATOM   1569 O  OE1    . GLU   A 1 218 ? 130.059 109.627 6.172   1.00 86.99  ?  329 GLU   A OE1    1 
ATOM   1570 O  OE2    . GLU   A 1 218 ? 132.068 110.510 6.378   1.00 100.34 -1 329 GLU   A OE2    1 
ATOM   1571 N  N      . ALA   A 1 219 ? 130.493 114.202 2.871   1.00 65.51  ?  330 ALA   A N      1 
ATOM   1572 C  CA     . ALA   A 1 219 ? 131.414 115.299 2.522   1.00 65.33  ?  330 ALA   A CA     1 
ATOM   1573 C  C      . ALA   A 1 219 ? 131.337 116.500 3.469   1.00 69.62  ?  330 ALA   A C      1 
ATOM   1574 O  O      . ALA   A 1 219 ? 132.361 117.135 3.730   1.00 69.30  ?  330 ALA   A O      1 
ATOM   1575 C  CB     . ALA   A 1 219 ? 131.164 115.758 1.101   1.00 65.92  ?  330 ALA   A CB     1 
ATOM   1576 N  N      . ARG   A 1 220 ? 130.125 116.806 3.975   1.00 65.78  ?  331 ARG   A N      1 
ATOM   1577 C  CA     . ARG   A 1 220 ? 129.861 117.888 4.932   1.00 65.00  ?  331 ARG   A CA     1 
ATOM   1578 C  C      . ARG   A 1 220 ? 130.581 117.634 6.272   1.00 69.50  ?  331 ARG   A C      1 
ATOM   1579 O  O      . ARG   A 1 220 ? 130.861 118.593 6.993   1.00 69.75  ?  331 ARG   A O      1 
ATOM   1580 C  CB     . ARG   A 1 220 ? 128.347 118.049 5.155   1.00 62.15  ?  331 ARG   A CB     1 
ATOM   1581 C  CG     . ARG   A 1 220 ? 127.653 118.894 4.094   1.00 67.33  ?  331 ARG   A CG     1 
ATOM   1582 C  CD     . ARG   A 1 220 ? 126.146 118.682 4.092   1.00 63.25  ?  331 ARG   A CD     1 
ATOM   1583 N  NE     . ARG   A 1 220 ? 125.418 119.729 4.816   1.00 59.36  ?  331 ARG   A NE     1 
ATOM   1584 C  CZ     . ARG   A 1 220 ? 124.880 119.578 6.024   1.00 69.33  ?  331 ARG   A CZ     1 
ATOM   1585 N  NH1    . ARG   A 1 220 ? 124.214 120.577 6.591   1.00 46.57  1  331 ARG   A NH1    1 
ATOM   1586 N  NH2    . ARG   A 1 220 ? 124.993 118.422 6.671   1.00 58.09  ?  331 ARG   A NH2    1 
ATOM   1587 N  N      . LYS   A 1 221 ? 130.875 116.348 6.593   1.00 65.56  ?  332 LYS   A N      1 
ATOM   1588 C  CA     . LYS   A 1 221 ? 131.581 115.917 7.807   1.00 65.63  ?  332 LYS   A CA     1 
ATOM   1589 C  C      . LYS   A 1 221 ? 133.115 115.997 7.621   1.00 71.48  ?  332 LYS   A C      1 
ATOM   1590 O  O      . LYS   A 1 221 ? 133.860 115.813 8.588   1.00 72.17  ?  332 LYS   A O      1 
ATOM   1591 C  CB     . LYS   A 1 221 ? 131.168 114.489 8.216   1.00 67.52  ?  332 LYS   A CB     1 
ATOM   1592 C  CG     . LYS   A 1 221 ? 129.723 114.348 8.676   1.00 78.87  ?  332 LYS   A CG     1 
ATOM   1593 C  CD     . LYS   A 1 221 ? 129.404 112.911 9.088   1.00 86.37  ?  332 LYS   A CD     1 
ATOM   1594 C  CE     . LYS   A 1 221 ? 128.242 112.309 8.333   1.00 97.35  ?  332 LYS   A CE     1 
ATOM   1595 N  NZ     . LYS   A 1 221 ? 126.935 112.874 8.765   1.00 107.31 1  332 LYS   A NZ     1 
ATOM   1596 N  N      . HIS   A 1 222 ? 133.579 116.278 6.385   1.00 68.21  ?  333 HIS   A N      1 
ATOM   1597 C  CA     . HIS   A 1 222 ? 135.000 116.408 6.043   1.00 68.08  ?  333 HIS   A CA     1 
ATOM   1598 C  C      . HIS   A 1 222 ? 135.315 117.809 5.505   1.00 73.34  ?  333 HIS   A C      1 
ATOM   1599 O  O      . HIS   A 1 222 ? 136.486 118.174 5.394   1.00 73.65  ?  333 HIS   A O      1 
ATOM   1600 C  CB     . HIS   A 1 222 ? 135.408 115.356 4.997   1.00 68.91  ?  333 HIS   A CB     1 
ATOM   1601 C  CG     . HIS   A 1 222 ? 135.274 113.935 5.452   1.00 72.45  ?  333 HIS   A CG     1 
ATOM   1602 N  ND1    . HIS   A 1 222 ? 136.386 113.150 5.700   1.00 74.34  ?  333 HIS   A ND1    1 
ATOM   1603 C  CD2    . HIS   A 1 222 ? 134.161 113.191 5.655   1.00 74.23  ?  333 HIS   A CD2    1 
ATOM   1604 C  CE1    . HIS   A 1 222 ? 135.918 111.966 6.059   1.00 73.85  ?  333 HIS   A CE1    1 
ATOM   1605 N  NE2    . HIS   A 1 222 ? 134.583 111.944 6.050   1.00 74.16  ?  333 HIS   A NE2    1 
ATOM   1606 N  N      . GLY   A 1 223 ? 134.275 118.567 5.157   1.00 70.61  ?  334 GLY   A N      1 
ATOM   1607 C  CA     . GLY   A 1 223 ? 134.390 119.903 4.577   1.00 70.70  ?  334 GLY   A CA     1 
ATOM   1608 C  C      . GLY   A 1 223 ? 134.936 119.886 3.159   1.00 75.13  ?  334 GLY   A C      1 
ATOM   1609 O  O      . GLY   A 1 223 ? 135.465 120.896 2.684   1.00 74.90  ?  334 GLY   A O      1 
ATOM   1610 N  N      . LYS   A 1 224 ? 134.812 118.732 2.471   1.00 71.44  ?  335 LYS   A N      1 
ATOM   1611 C  CA     . LYS   A 1 224 ? 135.324 118.542 1.113   1.00 70.85  ?  335 LYS   A CA     1 
ATOM   1612 C  C      . LYS   A 1 224 ? 134.218 118.568 0.041   1.00 72.13  ?  335 LYS   A C      1 
ATOM   1613 O  O      . LYS   A 1 224 ? 133.028 118.569 0.368   1.00 71.15  ?  335 LYS   A O      1 
ATOM   1614 C  CB     . LYS   A 1 224 ? 136.198 117.284 1.025   1.00 73.73  ?  335 LYS   A CB     1 
ATOM   1615 C  CG     . LYS   A 1 224 ? 137.565 117.439 1.692   1.00 85.84  ?  335 LYS   A CG     1 
ATOM   1616 C  CD     . LYS   A 1 224 ? 138.432 116.208 1.481   1.00 94.30  ?  335 LYS   A CD     1 
ATOM   1617 C  CE     . LYS   A 1 224 ? 139.763 116.286 2.186   1.00 105.50 ?  335 LYS   A CE     1 
ATOM   1618 N  NZ     . LYS   A 1 224 ? 140.545 115.033 2.011   1.00 113.55 1  335 LYS   A NZ     1 
ATOM   1619 N  N      . ALA   A 1 225 ? 134.629 118.638 -1.238  1.00 67.14  ?  336 ALA   A N      1 
ATOM   1620 C  CA     . ALA   A 1 225 ? 133.732 118.799 -2.378  1.00 66.07  ?  336 ALA   A CA     1 
ATOM   1621 C  C      . ALA   A 1 225 ? 133.281 117.522 -3.077  1.00 65.77  ?  336 ALA   A C      1 
ATOM   1622 O  O      . ALA   A 1 225 ? 134.031 116.546 -3.146  1.00 64.37  ?  336 ALA   A O      1 
ATOM   1623 C  CB     . ALA   A 1 225 ? 134.367 119.734 -3.397  1.00 67.01  ?  336 ALA   A CB     1 
ATOM   1624 N  N      A ILE   A 1 226 ? 132.051 117.578 -3.628  0.49 60.82  ?  337 ILE   A N      1 
ATOM   1625 N  N      B ILE   A 1 226 ? 132.045 117.527 -3.606  0.51 61.64  ?  337 ILE   A N      1 
ATOM   1626 C  CA     A ILE   A 1 226 ? 131.350 116.518 -4.352  0.49 59.57  ?  337 ILE   A CA     1 
ATOM   1627 C  CA     B ILE   A 1 226 ? 131.529 116.396 -4.376  0.51 60.80  ?  337 ILE   A CA     1 
ATOM   1628 C  C      A ILE   A 1 226 ? 131.111 116.924 -5.815  0.49 62.55  ?  337 ILE   A C      1 
ATOM   1629 C  C      B ILE   A 1 226 ? 131.106 116.854 -5.770  0.51 63.17  ?  337 ILE   A C      1 
ATOM   1630 O  O      A ILE   A 1 226 ? 130.678 118.051 -6.081  0.49 61.92  ?  337 ILE   A O      1 
ATOM   1631 O  O      B ILE   A 1 226 ? 130.582 117.957 -5.949  0.51 62.68  ?  337 ILE   A O      1 
ATOM   1632 C  CB     A ILE   A 1 226 ? 130.008 116.207 -3.603  0.49 62.20  ?  337 ILE   A CB     1 
ATOM   1633 C  CB     B ILE   A 1 226 ? 130.462 115.505 -3.688  0.51 63.90  ?  337 ILE   A CB     1 
ATOM   1634 C  CG1    A ILE   A 1 226 ? 130.233 115.372 -2.315  0.49 62.39  ?  337 ILE   A CG1    1 
ATOM   1635 C  CG1    B ILE   A 1 226 ? 129.213 116.298 -3.274  0.51 64.40  ?  337 ILE   A CG1    1 
ATOM   1636 C  CG2    A ILE   A 1 226 ? 128.920 115.581 -4.493  0.49 62.55  ?  337 ILE   A CG2    1 
ATOM   1637 C  CG2    B ILE   A 1 226 ? 131.053 114.711 -2.524  0.51 64.47  ?  337 ILE   A CG2    1 
ATOM   1638 C  CD1    A ILE   A 1 226 ? 130.951 114.001 -2.441  0.49 67.43  ?  337 ILE   A CD1    1 
ATOM   1639 C  CD1    B ILE   A 1 226 ? 127.938 115.661 -3.772  0.51 72.62  ?  337 ILE   A CD1    1 
ATOM   1640 N  N      . ILE   A 1 227 ? 131.373 115.997 -6.756  1.00 59.10  ?  338 ILE   A N      1 
ATOM   1641 C  CA     . ILE   A 1 227 ? 131.092 116.223 -8.168  1.00 58.49  ?  338 ILE   A CA     1 
ATOM   1642 C  C      . ILE   A 1 227 ? 129.863 115.360 -8.548  1.00 60.94  ?  338 ILE   A C      1 
ATOM   1643 O  O      . ILE   A 1 227 ? 129.929 114.132 -8.451  1.00 60.33  ?  338 ILE   A O      1 
ATOM   1644 C  CB     . ILE   A 1 227 ? 132.371 115.984 -9.029  1.00 61.20  ?  338 ILE   A CB     1 
ATOM   1645 C  CG1    . ILE   A 1 227 ? 133.217 117.280 -9.111  1.00 60.77  ?  338 ILE   A CG1    1 
ATOM   1646 C  CG2    . ILE   A 1 227 ? 132.044 115.456 -10.424 1.00 61.96  ?  338 ILE   A CG2    1 
ATOM   1647 C  CD1    . ILE   A 1 227 ? 134.672 117.130 -9.711  1.00 63.87  ?  338 ILE   A CD1    1 
ATOM   1648 N  N      . ALA   A 1 228 ? 128.726 116.014 -8.905  1.00 55.79  ?  339 ALA   A N      1 
ATOM   1649 C  CA     . ALA   A 1 228 ? 127.505 115.309 -9.328  1.00 54.77  ?  339 ALA   A CA     1 
ATOM   1650 C  C      . ALA   A 1 228 ? 127.727 114.917 -10.784 1.00 57.09  ?  339 ALA   A C      1 
ATOM   1651 O  O      . ALA   A 1 228 ? 127.670 115.762 -11.684 1.00 56.79  ?  339 ALA   A O      1 
ATOM   1652 C  CB     . ALA   A 1 228 ? 126.284 116.204 -9.181  1.00 55.39  ?  339 ALA   A CB     1 
ATOM   1653 N  N      . ASP   A 1 229 ? 128.064 113.641 -10.994 1.00 52.39  ?  340 ASP   A N      1 
ATOM   1654 C  CA     . ASP   A 1 229 ? 128.435 113.108 -12.294 1.00 51.38  ?  340 ASP   A CA     1 
ATOM   1655 C  C      . ASP   A 1 229 ? 127.406 112.190 -12.974 1.00 53.57  ?  340 ASP   A C      1 
ATOM   1656 O  O      . ASP   A 1 229 ? 127.218 111.050 -12.561 1.00 53.52  ?  340 ASP   A O      1 
ATOM   1657 C  CB     . ASP   A 1 229 ? 129.789 112.387 -12.138 1.00 52.89  ?  340 ASP   A CB     1 
ATOM   1658 C  CG     . ASP   A 1 229 ? 130.407 111.831 -13.399 1.00 57.98  ?  340 ASP   A CG     1 
ATOM   1659 O  OD1    . ASP   A 1 229 ? 129.987 112.238 -14.492 1.00 59.40  ?  340 ASP   A OD1    1 
ATOM   1660 O  OD2    . ASP   A 1 229 ? 131.287 110.964 -13.287 1.00 59.32  -1 340 ASP   A OD2    1 
ATOM   1661 N  N      . GLY   A 1 230 ? 126.825 112.684 -14.068 1.00 49.14  ?  341 GLY   A N      1 
ATOM   1662 C  CA     . GLY   A 1 230 ? 125.925 111.921 -14.930 1.00 48.17  ?  341 GLY   A CA     1 
ATOM   1663 C  C      . GLY   A 1 230 ? 124.434 112.000 -14.685 1.00 48.68  ?  341 GLY   A C      1 
ATOM   1664 O  O      . GLY   A 1 230 ? 123.991 112.312 -13.577 1.00 45.75  ?  341 GLY   A O      1 
ATOM   1665 N  N      . GLY   A 1 231 ? 123.677 111.688 -15.741 1.00 45.11  ?  342 GLY   A N      1 
ATOM   1666 C  CA     . GLY   A 1 231 ? 122.219 111.634 -15.727 1.00 45.34  ?  342 GLY   A CA     1 
ATOM   1667 C  C      . GLY   A 1 231 ? 121.516 112.949 -15.992 1.00 50.50  ?  342 GLY   A C      1 
ATOM   1668 O  O      . GLY   A 1 231 ? 120.289 112.978 -16.058 1.00 50.28  ?  342 GLY   A O      1 
ATOM   1669 N  N      . ILE   A 1 232 ? 122.277 114.037 -16.165 1.00 47.99  ?  343 ILE   A N      1 
ATOM   1670 C  CA     . ILE   A 1 232 ? 121.726 115.364 -16.433 1.00 49.18  ?  343 ILE   A CA     1 
ATOM   1671 C  C      . ILE   A 1 232 ? 121.295 115.455 -17.900 1.00 57.65  ?  343 ILE   A C      1 
ATOM   1672 O  O      . ILE   A 1 232 ? 122.108 115.236 -18.800 1.00 59.70  ?  343 ILE   A O      1 
ATOM   1673 C  CB     . ILE   A 1 232 ? 122.717 116.476 -16.001 1.00 52.18  ?  343 ILE   A CB     1 
ATOM   1674 C  CG1    . ILE   A 1 232 ? 122.957 116.429 -14.467 1.00 52.43  ?  343 ILE   A CG1    1 
ATOM   1675 C  CG2    . ILE   A 1 232 ? 122.207 117.866 -16.424 1.00 53.67  ?  343 ILE   A CG2    1 
ATOM   1676 C  CD1    . ILE   A 1 232 ? 124.375 116.629 -14.034 1.00 54.61  ?  343 ILE   A CD1    1 
ATOM   1677 N  N      . LYS   A 1 233 ? 120.007 115.743 -18.125 1.00 54.90  ?  344 LYS   A N      1 
ATOM   1678 C  CA     . LYS   A 1 233 ? 119.394 115.826 -19.453 1.00 54.46  ?  344 LYS   A CA     1 
ATOM   1679 C  C      . LYS   A 1 233 ? 119.088 117.269 -19.839 1.00 59.28  ?  344 LYS   A C      1 
ATOM   1680 O  O      . LYS   A 1 233 ? 119.050 117.582 -21.027 1.00 59.26  ?  344 LYS   A O      1 
ATOM   1681 C  CB     . LYS   A 1 233 ? 118.084 115.014 -19.497 1.00 56.03  ?  344 LYS   A CB     1 
ATOM   1682 C  CG     . LYS   A 1 233 ? 118.148 113.635 -18.838 1.00 61.43  ?  344 LYS   A CG     1 
ATOM   1683 C  CD     . LYS   A 1 233 ? 116.761 112.960 -18.703 1.00 64.42  ?  344 LYS   A CD     1 
ATOM   1684 C  CE     . LYS   A 1 233 ? 115.828 113.562 -17.659 1.00 64.54  ?  344 LYS   A CE     1 
ATOM   1685 N  NZ     . LYS   A 1 233 ? 116.338 113.406 -16.271 1.00 61.14  1  344 LYS   A NZ     1 
ATOM   1686 N  N      . PHE   A 1 234 ? 118.810 118.128 -18.840 1.00 56.16  ?  345 PHE   A N      1 
ATOM   1687 C  CA     . PHE   A 1 234 ? 118.445 119.536 -19.017 1.00 56.30  ?  345 PHE   A CA     1 
ATOM   1688 C  C      . PHE   A 1 234 ? 118.999 120.385 -17.872 1.00 59.83  ?  345 PHE   A C      1 
ATOM   1689 O  O      . PHE   A 1 234 ? 119.442 119.842 -16.859 1.00 59.30  ?  345 PHE   A O      1 
ATOM   1690 C  CB     . PHE   A 1 234 ? 116.911 119.702 -19.018 1.00 58.94  ?  345 PHE   A CB     1 
ATOM   1691 C  CG     . PHE   A 1 234 ? 116.073 118.619 -19.648 1.00 61.36  ?  345 PHE   A CG     1 
ATOM   1692 C  CD1    . PHE   A 1 234 ? 115.809 118.628 -21.013 1.00 65.45  ?  345 PHE   A CD1    1 
ATOM   1693 C  CD2    . PHE   A 1 234 ? 115.478 117.637 -18.866 1.00 63.76  ?  345 PHE   A CD2    1 
ATOM   1694 C  CE1    . PHE   A 1 234 ? 114.998 117.645 -21.592 1.00 66.19  ?  345 PHE   A CE1    1 
ATOM   1695 C  CE2    . PHE   A 1 234 ? 114.670 116.656 -19.446 1.00 66.73  ?  345 PHE   A CE2    1 
ATOM   1696 C  CZ     . PHE   A 1 234 ? 114.436 116.667 -20.805 1.00 64.93  ?  345 PHE   A CZ     1 
ATOM   1697 N  N      . SER   A 1 235 ? 118.892 121.724 -18.007 1.00 56.89  ?  346 SER   A N      1 
ATOM   1698 C  CA     . SER   A 1 235 ? 119.310 122.735 -17.021 1.00 56.13  ?  346 SER   A CA     1 
ATOM   1699 C  C      . SER   A 1 235 ? 118.633 122.528 -15.650 1.00 59.76  ?  346 SER   A C      1 
ATOM   1700 O  O      . SER   A 1 235 ? 119.245 122.813 -14.617 1.00 59.33  ?  346 SER   A O      1 
ATOM   1701 C  CB     . SER   A 1 235 ? 118.990 124.129 -17.542 1.00 58.93  ?  346 SER   A CB     1 
ATOM   1702 O  OG     . SER   A 1 235 ? 117.631 124.230 -17.932 1.00 67.56  ?  346 SER   A OG     1 
ATOM   1703 N  N      . GLY   A 1 236 ? 117.388 122.026 -15.668 1.00 54.69  ?  347 GLY   A N      1 
ATOM   1704 C  CA     . GLY   A 1 236 ? 116.613 121.714 -14.471 1.00 54.13  ?  347 GLY   A CA     1 
ATOM   1705 C  C      . GLY   A 1 236 ? 117.247 120.616 -13.635 1.00 55.87  ?  347 GLY   A C      1 
ATOM   1706 O  O      . GLY   A 1 236 ? 117.152 120.638 -12.408 1.00 55.65  ?  347 GLY   A O      1 
ATOM   1707 N  N      . ASP   A 1 237 ? 117.935 119.670 -14.294 1.00 50.54  ?  348 ASP   A N      1 
ATOM   1708 C  CA     . ASP   A 1 237 ? 118.649 118.585 -13.630 1.00 49.33  ?  348 ASP   A CA     1 
ATOM   1709 C  C      . ASP   A 1 237 ? 119.982 119.102 -13.066 1.00 51.42  ?  348 ASP   A C      1 
ATOM   1710 O  O      . ASP   A 1 237 ? 120.561 118.468 -12.175 1.00 49.00  ?  348 ASP   A O      1 
ATOM   1711 C  CB     . ASP   A 1 237 ? 118.883 117.415 -14.598 1.00 50.63  ?  348 ASP   A CB     1 
ATOM   1712 C  CG     . ASP   A 1 237 ? 117.631 116.724 -15.109 1.00 59.63  ?  348 ASP   A CG     1 
ATOM   1713 O  OD1    . ASP   A 1 237 ? 116.558 116.876 -14.474 1.00 59.10  ?  348 ASP   A OD1    1 
ATOM   1714 O  OD2    . ASP   A 1 237 ? 117.732 115.990 -16.116 1.00 67.44  -1 348 ASP   A OD2    1 
ATOM   1715 N  N      . ILE   A 1 238 ? 120.465 120.252 -13.578 1.00 48.12  ?  349 ILE   A N      1 
ATOM   1716 C  CA     . ILE   A 1 238 ? 121.703 120.843 -13.075 1.00 48.32  ?  349 ILE   A CA     1 
ATOM   1717 C  C      . ILE   A 1 238 ? 121.438 121.406 -11.693 1.00 53.02  ?  349 ILE   A C      1 
ATOM   1718 O  O      . ILE   A 1 238 ? 122.118 121.029 -10.752 1.00 52.64  ?  349 ILE   A O      1 
ATOM   1719 C  CB     . ILE   A 1 238 ? 122.361 121.869 -14.031 1.00 51.59  ?  349 ILE   A CB     1 
ATOM   1720 C  CG1    . ILE   A 1 238 ? 122.708 121.230 -15.395 1.00 52.08  ?  349 ILE   A CG1    1 
ATOM   1721 C  CG2    . ILE   A 1 238 ? 123.603 122.495 -13.370 1.00 51.87  ?  349 ILE   A CG2    1 
ATOM   1722 C  CD1    . ILE   A 1 238 ? 123.226 122.207 -16.504 1.00 61.44  ?  349 ILE   A CD1    1 
ATOM   1723 N  N      . ILE   A 1 239 ? 120.414 122.257 -11.562 1.00 52.52  ?  350 ILE   A N      1 
ATOM   1724 C  CA     . ILE   A 1 239 ? 120.043 122.847 -10.281 1.00 52.77  ?  350 ILE   A CA     1 
ATOM   1725 C  C      . ILE   A 1 239 ? 119.594 121.756 -9.264  1.00 55.79  ?  350 ILE   A C      1 
ATOM   1726 O  O      . ILE   A 1 239 ? 119.956 121.882 -8.091  1.00 55.56  ?  350 ILE   A O      1 
ATOM   1727 C  CB     . ILE   A 1 239 ? 119.034 124.006 -10.463 1.00 56.35  ?  350 ILE   A CB     1 
ATOM   1728 C  CG1    . ILE   A 1 239 ? 118.873 124.812 -9.164  1.00 56.98  ?  350 ILE   A CG1    1 
ATOM   1729 C  CG2    . ILE   A 1 239 ? 117.697 123.533 -11.028 1.00 58.20  ?  350 ILE   A CG2    1 
ATOM   1730 C  CD1    . ILE   A 1 239 ? 118.584 126.217 -9.349  1.00 66.55  ?  350 ILE   A CD1    1 
ATOM   1731 N  N      . LYS   A 1 240 ? 118.875 120.677 -9.719  1.00 50.15  ?  351 LYS   A N      1 
ATOM   1732 C  CA     . LYS   A 1 240 ? 118.442 119.554 -8.866  1.00 49.43  ?  351 LYS   A CA     1 
ATOM   1733 C  C      . LYS   A 1 240 ? 119.657 118.839 -8.297  1.00 53.36  ?  351 LYS   A C      1 
ATOM   1734 O  O      . LYS   A 1 240 ? 119.688 118.557 -7.099  1.00 52.57  ?  351 LYS   A O      1 
ATOM   1735 C  CB     . LYS   A 1 240 ? 117.572 118.520 -9.626  1.00 50.13  ?  351 LYS   A CB     1 
ATOM   1736 C  CG     . LYS   A 1 240 ? 116.134 118.942 -9.880  1.00 48.18  ?  351 LYS   A CG     1 
ATOM   1737 C  CD     . LYS   A 1 240 ? 115.354 117.822 -10.585 1.00 38.88  ?  351 LYS   A CD     1 
ATOM   1738 C  CE     . LYS   A 1 240 ? 114.166 118.370 -11.337 1.00 45.46  ?  351 LYS   A CE     1 
ATOM   1739 N  NZ     . LYS   A 1 240 ? 113.252 117.302 -11.842 1.00 42.85  1  351 LYS   A NZ     1 
ATOM   1740 N  N      . ALA   A 1 241 ? 120.652 118.545 -9.153  1.00 51.56  ?  352 ALA   A N      1 
ATOM   1741 C  CA     . ALA   A 1 241 ? 121.900 117.879 -8.752  1.00 52.38  ?  352 ALA   A CA     1 
ATOM   1742 C  C      . ALA   A 1 241 ? 122.658 118.720 -7.722  1.00 56.87  ?  352 ALA   A C      1 
ATOM   1743 O  O      . ALA   A 1 241 ? 123.133 118.177 -6.719  1.00 56.99  ?  352 ALA   A O      1 
ATOM   1744 C  CB     . ALA   A 1 241 ? 122.785 117.643 -9.966  1.00 53.22  ?  352 ALA   A CB     1 
ATOM   1745 N  N      . LEU   A 1 242 ? 122.747 120.042 -7.964  1.00 53.22  ?  353 LEU   A N      1 
ATOM   1746 C  CA     . LEU   A 1 242 ? 123.454 120.961 -7.068  1.00 53.53  ?  353 LEU   A CA     1 
ATOM   1747 C  C      . LEU   A 1 242 ? 122.725 121.136 -5.736  1.00 55.24  ?  353 LEU   A C      1 
ATOM   1748 O  O      . LEU   A 1 242 ? 123.364 121.086 -4.689  1.00 55.32  ?  353 LEU   A O      1 
ATOM   1749 C  CB     . LEU   A 1 242 ? 123.709 122.324 -7.733  1.00 54.00  ?  353 LEU   A CB     1 
ATOM   1750 C  CG     . LEU   A 1 242 ? 124.585 122.347 -8.993  1.00 58.98  ?  353 LEU   A CG     1 
ATOM   1751 C  CD1    . LEU   A 1 242 ? 124.327 123.602 -9.789  1.00 59.51  ?  353 LEU   A CD1    1 
ATOM   1752 C  CD2    . LEU   A 1 242 ? 126.060 122.264 -8.657  1.00 59.55  ?  353 LEU   A CD2    1 
ATOM   1753 N  N      . ALA   A 1 243 ? 121.395 121.280 -5.774  1.00 50.67  ?  354 ALA   A N      1 
ATOM   1754 C  CA     . ALA   A 1 243 ? 120.567 121.459 -4.577  1.00 50.04  ?  354 ALA   A CA     1 
ATOM   1755 C  C      . ALA   A 1 243 ? 120.524 120.221 -3.699  1.00 53.67  ?  354 ALA   A C      1 
ATOM   1756 O  O      . ALA   A 1 243 ? 120.325 120.352 -2.492  1.00 53.74  ?  354 ALA   A O      1 
ATOM   1757 C  CB     . ALA   A 1 243 ? 119.170 121.886 -4.959  1.00 50.68  ?  354 ALA   A CB     1 
ATOM   1758 N  N      . ALA   A 1 244 ? 120.763 119.023 -4.289  1.00 49.23  ?  355 ALA   A N      1 
ATOM   1759 C  CA     . ALA   A 1 244 ? 120.798 117.753 -3.569  1.00 48.39  ?  355 ALA   A CA     1 
ATOM   1760 C  C      . ALA   A 1 244 ? 122.095 117.598 -2.778  1.00 53.58  ?  355 ALA   A C      1 
ATOM   1761 O  O      . ALA   A 1 244 ? 122.210 116.669 -1.968  1.00 51.70  ?  355 ALA   A O      1 
ATOM   1762 C  CB     . ALA   A 1 244 ? 120.623 116.588 -4.540  1.00 48.67  ?  355 ALA   A CB     1 
ATOM   1763 N  N      . GLY   A 1 245 ? 123.067 118.477 -3.051  1.00 53.39  ?  356 GLY   A N      1 
ATOM   1764 C  CA     . GLY   A 1 245 ? 124.360 118.489 -2.374  1.00 54.53  ?  356 GLY   A CA     1 
ATOM   1765 C  C      . GLY   A 1 245 ? 125.608 118.682 -3.220  1.00 61.35  ?  356 GLY   A C      1 
ATOM   1766 O  O      . GLY   A 1 245 ? 126.681 118.941 -2.667  1.00 60.86  ?  356 GLY   A O      1 
ATOM   1767 N  N      . GLY   A 1 246 ? 125.481 118.534 -4.544  1.00 59.66  ?  357 GLY   A N      1 
ATOM   1768 C  CA     . GLY   A 1 246 ? 126.590 118.659 -5.488  1.00 59.46  ?  357 GLY   A CA     1 
ATOM   1769 C  C      . GLY   A 1 246 ? 127.226 120.032 -5.549  1.00 63.93  ?  357 GLY   A C      1 
ATOM   1770 O  O      . GLY   A 1 246 ? 126.523 121.040 -5.573  1.00 62.95  ?  357 GLY   A O      1 
ATOM   1771 N  N      . HIS   A 1 247 ? 128.565 120.085 -5.561  1.00 62.94  ?  358 HIS   A N      1 
ATOM   1772 C  CA     . HIS   A 1 247 ? 129.276 121.366 -5.639  1.00 63.10  ?  358 HIS   A CA     1 
ATOM   1773 C  C      . HIS   A 1 247 ? 129.360 121.854 -7.082  1.00 65.30  ?  358 HIS   A C      1 
ATOM   1774 O  O      . HIS   A 1 247 ? 129.181 123.044 -7.345  1.00 64.73  ?  358 HIS   A O      1 
ATOM   1775 C  CB     . HIS   A 1 247 ? 130.637 121.280 -4.950  1.00 64.48  ?  358 HIS   A CB     1 
ATOM   1776 C  CG     . HIS   A 1 247 ? 130.509 121.119 -3.467  1.00 68.33  ?  358 HIS   A CG     1 
ATOM   1777 N  ND1    . HIS   A 1 247 ? 130.265 119.880 -2.893  1.00 70.26  ?  358 HIS   A ND1    1 
ATOM   1778 C  CD2    . HIS   A 1 247 ? 130.528 122.057 -2.493  1.00 70.20  ?  358 HIS   A CD2    1 
ATOM   1779 C  CE1    . HIS   A 1 247 ? 130.172 120.101 -1.593  1.00 69.71  ?  358 HIS   A CE1    1 
ATOM   1780 N  NE2    . HIS   A 1 247 ? 130.319 121.395 -1.305  1.00 70.12  ?  358 HIS   A NE2    1 
ATOM   1781 N  N      . ALA   A 1 248 ? 129.566 120.916 -8.020  1.00 61.32  ?  359 ALA   A N      1 
ATOM   1782 C  CA     . ALA   A 1 248 ? 129.607 121.169 -9.462  1.00 60.78  ?  359 ALA   A CA     1 
ATOM   1783 C  C      . ALA   A 1 248 ? 129.068 119.942 -10.221 1.00 62.67  ?  359 ALA   A C      1 
ATOM   1784 O  O      . ALA   A 1 248 ? 129.058 118.839 -9.671  1.00 62.16  ?  359 ALA   A O      1 
ATOM   1785 C  CB     . ALA   A 1 248 ? 131.024 121.497 -9.906  1.00 61.56  ?  359 ALA   A CB     1 
ATOM   1786 N  N      . VAL   A 1 249 ? 128.603 120.146 -11.469 1.00 57.36  ?  360 VAL   A N      1 
ATOM   1787 C  CA     . VAL   A 1 249 ? 128.044 119.090 -12.317 1.00 56.65  ?  360 VAL   A CA     1 
ATOM   1788 C  C      . VAL   A 1 249 ? 128.989 118.690 -13.445 1.00 61.46  ?  360 VAL   A C      1 
ATOM   1789 O  O      . VAL   A 1 249 ? 129.722 119.530 -13.961 1.00 61.58  ?  360 VAL   A O      1 
ATOM   1790 C  CB     . VAL   A 1 249 ? 126.620 119.399 -12.852 1.00 59.67  ?  360 VAL   A CB     1 
ATOM   1791 C  CG1    . VAL   A 1 249 ? 125.621 119.575 -11.707 1.00 58.87  ?  360 VAL   A CG1    1 
ATOM   1792 C  CG2    . VAL   A 1 249 ? 126.614 120.612 -13.795 1.00 59.38  ?  360 VAL   A CG2    1 
ATOM   1793 N  N      . MET   A 1 250 ? 128.976 117.395 -13.806 1.00 58.62  ?  361 MET   A N      1 
ATOM   1794 C  CA     . MET   A 1 250 ? 129.750 116.834 -14.906 1.00 58.05  ?  361 MET   A CA     1 
ATOM   1795 C  C      . MET   A 1 250 ? 128.791 116.467 -16.033 1.00 61.54  ?  361 MET   A C      1 
ATOM   1796 O  O      . MET   A 1 250 ? 127.895 115.647 -15.836 1.00 61.33  ?  361 MET   A O      1 
ATOM   1797 C  CB     . MET   A 1 250 ? 130.591 115.629 -14.481 1.00 60.30  ?  361 MET   A CB     1 
ATOM   1798 C  CG     . MET   A 1 250 ? 131.420 115.078 -15.635 1.00 63.99  ?  361 MET   A CG     1 
ATOM   1799 S  SD     . MET   A 1 250 ? 132.793 114.036 -15.132 1.00 68.16  ?  361 MET   A SD     1 
ATOM   1800 C  CE     . MET   A 1 250 ? 133.982 115.274 -14.660 1.00 65.04  ?  361 MET   A CE     1 
ATOM   1801 N  N      . LEU   A 1 251 ? 128.977 117.086 -17.207 1.00 57.39  ?  362 LEU   A N      1 
ATOM   1802 C  CA     . LEU   A 1 251 ? 128.119 116.864 -18.366 1.00 56.56  ?  362 LEU   A CA     1 
ATOM   1803 C  C      . LEU   A 1 251 ? 128.848 116.152 -19.484 1.00 59.46  ?  362 LEU   A C      1 
ATOM   1804 O  O      . LEU   A 1 251 ? 129.940 116.565 -19.882 1.00 58.54  ?  362 LEU   A O      1 
ATOM   1805 C  CB     . LEU   A 1 251 ? 127.524 118.185 -18.901 1.00 56.59  ?  362 LEU   A CB     1 
ATOM   1806 C  CG     . LEU   A 1 251 ? 126.878 119.181 -17.928 1.00 61.55  ?  362 LEU   A CG     1 
ATOM   1807 C  CD1    . LEU   A 1 251 ? 126.223 120.300 -18.694 1.00 61.95  ?  362 LEU   A CD1    1 
ATOM   1808 C  CD2    . LEU   A 1 251 ? 125.814 118.520 -17.056 1.00 64.50  ?  362 LEU   A CD2    1 
ATOM   1809 N  N      . GLY   A 1 252 ? 128.206 115.111 -20.001 1.00 55.65  ?  363 GLY   A N      1 
ATOM   1810 C  CA     . GLY   A 1 252 ? 128.694 114.324 -21.121 1.00 55.04  ?  363 GLY   A CA     1 
ATOM   1811 C  C      . GLY   A 1 252 ? 127.835 114.517 -22.356 1.00 57.62  ?  363 GLY   A C      1 
ATOM   1812 O  O      . GLY   A 1 252 ? 128.298 115.100 -23.340 1.00 56.53  ?  363 GLY   A O      1 
ATOM   1813 N  N      A SER   A 1 253 ? 126.577 114.036 -22.296 0.53 54.38  ?  364 SER   A N      1 
ATOM   1814 N  N      B SER   A 1 253 ? 126.572 114.037 -22.301 0.47 53.78  ?  364 SER   A N      1 
ATOM   1815 C  CA     A SER   A 1 253 ? 125.587 114.089 -23.374 0.53 54.32  ?  364 SER   A CA     1 
ATOM   1816 C  CA     B SER   A 1 253 ? 125.596 114.099 -23.395 0.47 53.44  ?  364 SER   A CA     1 
ATOM   1817 C  C      A SER   A 1 253 ? 125.253 115.498 -23.863 0.53 58.03  ?  364 SER   A C      1 
ATOM   1818 C  C      B SER   A 1 253 ? 125.265 115.509 -23.873 0.47 57.62  ?  364 SER   A C      1 
ATOM   1819 O  O      A SER   A 1 253 ? 125.149 115.702 -25.070 0.53 58.11  ?  364 SER   A O      1 
ATOM   1820 O  O      B SER   A 1 253 ? 125.172 115.725 -25.080 0.47 57.65  ?  364 SER   A O      1 
ATOM   1821 C  CB     A SER   A 1 253 ? 124.312 113.361 -22.959 0.53 58.15  ?  364 SER   A CB     1 
ATOM   1822 C  CB     B SER   A 1 253 ? 124.315 113.350 -23.028 0.47 56.19  ?  364 SER   A CB     1 
ATOM   1823 O  OG     A SER   A 1 253 ? 123.408 113.225 -24.043 0.53 68.23  ?  364 SER   A OG     1 
ATOM   1824 O  OG     B SER   A 1 253 ? 123.456 114.110 -22.194 0.47 62.23  ?  364 SER   A OG     1 
ATOM   1825 N  N      . LEU   A 1 254 ? 125.076 116.454 -22.937 1.00 54.38  ?  365 LEU   A N      1 
ATOM   1826 C  CA     . LEU   A 1 254 ? 124.717 117.845 -23.250 1.00 54.99  ?  365 LEU   A CA     1 
ATOM   1827 C  C      . LEU   A 1 254 ? 125.818 118.660 -23.954 1.00 61.35  ?  365 LEU   A C      1 
ATOM   1828 O  O      . LEU   A 1 254 ? 125.508 119.680 -24.577 1.00 61.81  ?  365 LEU   A O      1 
ATOM   1829 C  CB     . LEU   A 1 254 ? 124.236 118.579 -21.982 1.00 54.83  ?  365 LEU   A CB     1 
ATOM   1830 C  CG     . LEU   A 1 254 ? 122.822 118.249 -21.466 1.00 59.87  ?  365 LEU   A CG     1 
ATOM   1831 C  CD1    . LEU   A 1 254 ? 122.600 118.839 -20.085 1.00 59.88  ?  365 LEU   A CD1    1 
ATOM   1832 C  CD2    . LEU   A 1 254 ? 121.738 118.780 -22.405 1.00 62.66  ?  365 LEU   A CD2    1 
ATOM   1833 N  N      . LEU   A 1 255 ? 127.085 118.224 -23.863 1.00 58.47  ?  366 LEU   A N      1 
ATOM   1834 C  CA     . LEU   A 1 255 ? 128.204 118.945 -24.478 1.00 58.86  ?  366 LEU   A CA     1 
ATOM   1835 C  C      . LEU   A 1 255 ? 128.900 118.178 -25.621 1.00 65.02  ?  366 LEU   A C      1 
ATOM   1836 O  O      . LEU   A 1 255 ? 129.872 118.681 -26.188 1.00 65.67  ?  366 LEU   A O      1 
ATOM   1837 C  CB     . LEU   A 1 255 ? 129.222 119.381 -23.402 1.00 58.70  ?  366 LEU   A CB     1 
ATOM   1838 C  CG     . LEU   A 1 255 ? 128.679 120.157 -22.190 1.00 62.85  ?  366 LEU   A CG     1 
ATOM   1839 C  CD1    . LEU   A 1 255 ? 129.750 120.319 -21.134 1.00 62.49  ?  366 LEU   A CD1    1 
ATOM   1840 C  CD2    . LEU   A 1 255 ? 128.091 121.528 -22.591 1.00 64.86  ?  366 LEU   A CD2    1 
ATOM   1841 N  N      . ALA   A 1 256 ? 128.388 116.987 -25.983 1.00 62.20  ?  367 ALA   A N      1 
ATOM   1842 C  CA     . ALA   A 1 256 ? 128.966 116.155 -27.040 1.00 62.44  ?  367 ALA   A CA     1 
ATOM   1843 C  C      . ALA   A 1 256 ? 128.505 116.538 -28.446 1.00 67.45  ?  367 ALA   A C      1 
ATOM   1844 O  O      . ALA   A 1 256 ? 129.101 116.096 -29.433 1.00 65.87  ?  367 ALA   A O      1 
ATOM   1845 C  CB     . ALA   A 1 256 ? 128.669 114.692 -26.771 1.00 63.12  ?  367 ALA   A CB     1 
ATOM   1846 N  N      . GLY   A 1 257 ? 127.440 117.332 -28.518 1.00 66.65  ?  368 GLY   A N      1 
ATOM   1847 C  CA     . GLY   A 1 257 ? 126.858 117.811 -29.769 1.00 67.52  ?  368 GLY   A CA     1 
ATOM   1848 C  C      . GLY   A 1 257 ? 127.489 119.098 -30.258 1.00 73.19  ?  368 GLY   A C      1 
ATOM   1849 O  O      . GLY   A 1 257 ? 127.388 119.427 -31.441 1.00 72.98  ?  368 GLY   A O      1 
ATOM   1850 N  N      . THR   A 1 258 ? 128.145 119.832 -29.343 1.00 71.16  ?  369 THR   A N      1 
ATOM   1851 C  CA     . THR   A 1 258 ? 128.828 121.092 -29.636 1.00 71.80  ?  369 THR   A CA     1 
ATOM   1852 C  C      . THR   A 1 258 ? 130.055 120.871 -30.530 1.00 78.15  ?  369 THR   A C      1 
ATOM   1853 O  O      . THR   A 1 258 ? 130.670 119.799 -30.472 1.00 78.16  ?  369 THR   A O      1 
ATOM   1854 C  CB     . THR   A 1 258 ? 129.143 121.870 -28.344 1.00 78.03  ?  369 THR   A CB     1 
ATOM   1855 O  OG1    . THR   A 1 258 ? 129.983 121.085 -27.501 1.00 73.85  ?  369 THR   A OG1    1 
ATOM   1856 C  CG2    . THR   A 1 258 ? 127.880 122.286 -27.586 1.00 76.94  ?  369 THR   A CG2    1 
ATOM   1857 N  N      . GLU   A 1 259 ? 130.394 121.878 -31.370 1.00 75.77  ?  370 GLU   A N      1 
ATOM   1858 C  CA     . GLU   A 1 259 ? 131.523 121.844 -32.312 1.00 76.34  ?  370 GLU   A CA     1 
ATOM   1859 C  C      . GLU   A 1 259 ? 132.876 121.582 -31.624 1.00 81.25  ?  370 GLU   A C      1 
ATOM   1860 O  O      . GLU   A 1 259 ? 133.718 120.867 -32.176 1.00 81.04  ?  370 GLU   A O      1 
ATOM   1861 C  CB     . GLU   A 1 259 ? 131.563 123.136 -33.162 1.00 77.85  ?  370 GLU   A CB     1 
ATOM   1862 C  CG     . GLU   A 1 259 ? 132.593 123.153 -34.289 1.00 89.66  ?  370 GLU   A CG     1 
ATOM   1863 C  CD     . GLU   A 1 259 ? 132.477 122.047 -35.323 1.00 113.37 ?  370 GLU   A CD     1 
ATOM   1864 O  OE1    . GLU   A 1 259 ? 133.313 121.114 -35.293 1.00 105.52 ?  370 GLU   A OE1    1 
ATOM   1865 O  OE2    . GLU   A 1 259 ? 131.544 122.108 -36.157 1.00 109.14 -1 370 GLU   A OE2    1 
ATOM   1866 N  N      . GLU   A 1 260 ? 133.048 122.124 -30.406 1.00 78.22  ?  371 GLU   A N      1 
ATOM   1867 C  CA     . GLU   A 1 260 ? 134.251 122.024 -29.572 1.00 78.08  ?  371 GLU   A CA     1 
ATOM   1868 C  C      . GLU   A 1 260 ? 134.613 120.585 -29.148 1.00 83.13  ?  371 GLU   A C      1 
ATOM   1869 O  O      . GLU   A 1 260 ? 135.769 120.339 -28.805 1.00 82.46  ?  371 GLU   A O      1 
ATOM   1870 C  CB     . GLU   A 1 260 ? 134.142 122.951 -28.351 1.00 79.31  ?  371 GLU   A CB     1 
ATOM   1871 C  CG     . GLU   A 1 260 ? 134.038 124.431 -28.701 1.00 89.16  ?  371 GLU   A CG     1 
ATOM   1872 C  CD     . GLU   A 1 260 ? 132.683 124.977 -29.125 1.00 107.66 ?  371 GLU   A CD     1 
ATOM   1873 O  OE1    . GLU   A 1 260 ? 131.696 124.207 -29.165 1.00 93.48  ?  371 GLU   A OE1    1 
ATOM   1874 O  OE2    . GLU   A 1 260 ? 132.607 126.197 -29.398 1.00 104.97 -1 371 GLU   A OE2    1 
ATOM   1875 N  N      . SER   A 1 261 ? 133.640 119.644 -29.182 1.00 81.25  ?  372 SER   A N      1 
ATOM   1876 C  CA     . SER   A 1 261 ? 133.865 118.233 -28.840 1.00 81.92  ?  372 SER   A CA     1 
ATOM   1877 C  C      . SER   A 1 261 ? 134.743 117.539 -29.909 1.00 88.40  ?  372 SER   A C      1 
ATOM   1878 O  O      . SER   A 1 261 ? 134.612 117.870 -31.090 1.00 87.73  ?  372 SER   A O      1 
ATOM   1879 C  CB     . SER   A 1 261 ? 132.542 117.497 -28.643 1.00 84.62  ?  372 SER   A CB     1 
ATOM   1880 O  OG     . SER   A 1 261 ? 131.795 117.391 -29.842 1.00 92.16  ?  372 SER   A OG     1 
ATOM   1881 N  N      . PRO   A 1 262 ? 135.639 116.592 -29.520 1.00 87.54  ?  373 PRO   A N      1 
ATOM   1882 C  CA     . PRO   A 1 262 ? 136.547 115.964 -30.504 1.00 88.42  ?  373 PRO   A CA     1 
ATOM   1883 C  C      . PRO   A 1 262 ? 135.913 115.239 -31.692 1.00 95.35  ?  373 PRO   A C      1 
ATOM   1884 O  O      . PRO   A 1 262 ? 136.582 115.073 -32.716 1.00 94.79  ?  373 PRO   A O      1 
ATOM   1885 C  CB     . PRO   A 1 262 ? 137.375 114.991 -29.655 1.00 90.02  ?  373 PRO   A CB     1 
ATOM   1886 C  CG     . PRO   A 1 262 ? 136.604 114.806 -28.401 1.00 94.10  ?  373 PRO   A CG     1 
ATOM   1887 C  CD     . PRO   A 1 262 ? 135.941 116.113 -28.158 1.00 89.43  ?  373 PRO   A CD     1 
ATOM   1888 N  N      . GLY   A 1 263 ? 134.658 114.815 -31.548 1.00 94.47  ?  374 GLY   A N      1 
ATOM   1889 C  CA     . GLY   A 1 263 ? 133.913 114.114 -32.588 1.00 95.47  ?  374 GLY   A CA     1 
ATOM   1890 C  C      . GLY   A 1 263 ? 133.794 114.893 -33.885 1.00 101.79 ?  374 GLY   A C      1 
ATOM   1891 O  O      . GLY   A 1 263 ? 133.645 116.120 -33.864 1.00 101.69 ?  374 GLY   A O      1 
ATOM   1892 N  N      . ALA   A 1 264 ? 133.901 114.185 -35.024 1.00 99.41  ?  375 ALA   A N      1 
ATOM   1893 C  CA     . ALA   A 1 264 ? 133.799 114.787 -36.352 1.00 99.53  ?  375 ALA   A CA     1 
ATOM   1894 C  C      . ALA   A 1 264 ? 132.329 114.933 -36.750 1.00 103.87 ?  375 ALA   A C      1 
ATOM   1895 O  O      . ALA   A 1 264 ? 131.543 114.002 -36.552 1.00 103.22 ?  375 ALA   A O      1 
ATOM   1896 C  CB     . ALA   A 1 264 ? 134.544 113.940 -37.372 1.00 100.29 ?  375 ALA   A CB     1 
ATOM   1897 N  N      . THR   A 1 265 ? 131.960 116.113 -37.288 1.00 101.10 ?  376 THR   A N      1 
ATOM   1898 C  CA     . THR   A 1 265 ? 130.595 116.424 -37.728 1.00 101.28 ?  376 THR   A CA     1 
ATOM   1899 C  C      . THR   A 1 265 ? 130.247 115.599 -38.971 1.00 106.68 ?  376 THR   A C      1 
ATOM   1900 O  O      . THR   A 1 265 ? 131.008 115.580 -39.943 1.00 106.22 ?  376 THR   A O      1 
ATOM   1901 C  CB     . THR   A 1 265 ? 130.404 117.943 -37.923 1.00 106.89 ?  376 THR   A CB     1 
ATOM   1902 O  OG1    . THR   A 1 265 ? 130.917 118.642 -36.787 1.00 106.16 ?  376 THR   A OG1    1 
ATOM   1903 C  CG2    . THR   A 1 265 ? 128.943 118.331 -38.141 1.00 104.07 ?  376 THR   A CG2    1 
ATOM   1904 N  N      . GLU   A 1 266 ? 129.111 114.891 -38.910 1.00 104.30 ?  377 GLU   A N      1 
ATOM   1905 C  CA     . GLU   A 1 266 ? 128.621 114.031 -39.989 1.00 104.68 ?  377 GLU   A CA     1 
ATOM   1906 C  C      . GLU   A 1 266 ? 127.198 114.437 -40.396 1.00 109.32 ?  377 GLU   A C      1 
ATOM   1907 O  O      . GLU   A 1 266 ? 126.567 115.246 -39.709 1.00 108.56 ?  377 GLU   A O      1 
ATOM   1908 C  CB     . GLU   A 1 266 ? 128.653 112.545 -39.567 1.00 106.13 ?  377 GLU   A CB     1 
ATOM   1909 C  CG     . GLU   A 1 266 ? 129.969 112.036 -38.996 1.00 117.74 ?  377 GLU   A CG     1 
ATOM   1910 C  CD     . GLU   A 1 266 ? 131.081 111.787 -39.996 1.00 141.89 ?  377 GLU   A CD     1 
ATOM   1911 O  OE1    . GLU   A 1 266 ? 130.881 110.967 -40.922 1.00 137.42 ?  377 GLU   A OE1    1 
ATOM   1912 O  OE2    . GLU   A 1 266 ? 132.174 112.372 -39.819 1.00 138.01 -1 377 GLU   A OE2    1 
ATOM   1913 N  N      . ILE   A 1 267 ? 126.696 113.878 -41.513 1.00 106.97 ?  378 ILE   A N      1 
ATOM   1914 C  CA     . ILE   A 1 267 ? 125.351 114.164 -42.018 1.00 107.31 ?  378 ILE   A CA     1 
ATOM   1915 C  C      . ILE   A 1 267 ? 124.609 112.856 -42.367 1.00 111.94 ?  378 ILE   A C      1 
ATOM   1916 O  O      . ILE   A 1 267 ? 125.220 111.907 -42.866 1.00 111.46 ?  378 ILE   A O      1 
ATOM   1917 C  CB     . ILE   A 1 267 ? 125.374 115.221 -43.174 1.00 110.49 ?  378 ILE   A CB     1 
ATOM   1918 C  CG1    . ILE   A 1 267 ? 123.970 115.816 -43.439 1.00 110.98 ?  378 ILE   A CG1    1 
ATOM   1919 C  CG2    . ILE   A 1 267 ? 126.031 114.696 -44.464 1.00 111.30 ?  378 ILE   A CG2    1 
ATOM   1920 C  CD1    . ILE   A 1 267 ? 123.944 117.328 -43.652 1.00 118.06 ?  378 ILE   A CD1    1 
ATOM   1921 N  N      . PHE   A 1 268 ? 123.301 112.806 -42.048 1.00 109.30 ?  379 PHE   A N      1 
ATOM   1922 C  CA     . PHE   A 1 268 ? 122.420 111.663 -42.297 1.00 109.48 ?  379 PHE   A CA     1 
ATOM   1923 C  C      . PHE   A 1 268 ? 121.001 112.175 -42.529 1.00 112.61 ?  379 PHE   A C      1 
ATOM   1924 O  O      . PHE   A 1 268 ? 120.397 112.745 -41.614 1.00 112.27 ?  379 PHE   A O      1 
ATOM   1925 C  CB     . PHE   A 1 268 ? 122.472 110.669 -41.120 1.00 111.68 ?  379 PHE   A CB     1 
ATOM   1926 C  CG     . PHE   A 1 268 ? 121.901 109.297 -41.392 1.00 113.76 ?  379 PHE   A CG     1 
ATOM   1927 C  CD1    . PHE   A 1 268 ? 122.632 108.348 -42.098 1.00 117.28 ?  379 PHE   A CD1    1 
ATOM   1928 C  CD2    . PHE   A 1 268 ? 120.657 108.933 -40.889 1.00 116.35 ?  379 PHE   A CD2    1 
ATOM   1929 C  CE1    . PHE   A 1 268 ? 122.113 107.070 -42.329 1.00 118.46 ?  379 PHE   A CE1    1 
ATOM   1930 C  CE2    . PHE   A 1 268 ? 120.140 107.651 -41.116 1.00 119.41 ?  379 PHE   A CE2    1 
ATOM   1931 C  CZ     . PHE   A 1 268 ? 120.870 106.730 -41.835 1.00 117.61 ?  379 PHE   A CZ     1 
ATOM   1932 N  N      . GLN   A 1 269 ? 120.493 111.999 -43.772 1.00 108.27 ?  380 GLN   A N      1 
ATOM   1933 C  CA     . GLN   A 1 269 ? 119.169 112.438 -44.247 1.00 107.48 ?  380 GLN   A CA     1 
ATOM   1934 C  C      . GLN   A 1 269 ? 118.985 113.965 -44.105 1.00 109.77 ?  380 GLN   A C      1 
ATOM   1935 O  O      . GLN   A 1 269 ? 117.933 114.442 -43.664 1.00 109.30 ?  380 GLN   A O      1 
ATOM   1936 C  CB     . GLN   A 1 269 ? 118.022 111.631 -43.596 1.00 108.92 ?  380 GLN   A CB     1 
ATOM   1937 C  CG     . GLN   A 1 269 ? 117.904 110.204 -44.119 1.00 125.97 ?  380 GLN   A CG     1 
ATOM   1938 C  CD     . GLN   A 1 269 ? 116.821 109.435 -43.409 1.00 147.95 ?  380 GLN   A CD     1 
ATOM   1939 O  OE1    . GLN   A 1 269 ? 115.654 109.434 -43.815 1.00 143.55 ?  380 GLN   A OE1    1 
ATOM   1940 N  NE2    . GLN   A 1 269 ? 117.187 108.755 -42.331 1.00 140.73 ?  380 GLN   A NE2    1 
ATOM   1941 N  N      . GLY   A 1 270 ? 120.032 114.704 -44.479 1.00 105.14 ?  381 GLY   A N      1 
ATOM   1942 C  CA     . GLY   A 1 270 ? 120.081 116.163 -44.429 1.00 104.23 ?  381 GLY   A CA     1 
ATOM   1943 C  C      . GLY   A 1 270 ? 120.134 116.751 -43.033 1.00 106.18 ?  381 GLY   A C      1 
ATOM   1944 O  O      . GLY   A 1 270 ? 119.911 117.954 -42.862 1.00 105.93 ?  381 GLY   A O      1 
ATOM   1945 N  N      . ARG   A 1 271 ? 120.441 115.908 -42.026 1.00 100.66 ?  382 ARG   A N      1 
ATOM   1946 C  CA     . ARG   A 1 271 ? 120.514 116.292 -40.617 1.00 99.34  ?  382 ARG   A CA     1 
ATOM   1947 C  C      . ARG   A 1 271 ? 121.920 116.075 -40.054 1.00 100.41 ?  382 ARG   A C      1 
ATOM   1948 O  O      . ARG   A 1 271 ? 122.488 114.990 -40.206 1.00 99.85  ?  382 ARG   A O      1 
ATOM   1949 C  CB     . ARG   A 1 271 ? 119.463 115.526 -39.788 1.00 99.58  ?  382 ARG   A CB     1 
ATOM   1950 C  CG     . ARG   A 1 271 ? 118.007 115.874 -40.111 1.00 111.52 ?  382 ARG   A CG     1 
ATOM   1951 C  CD     . ARG   A 1 271 ? 117.476 117.019 -39.264 1.00 122.89 ?  382 ARG   A CD     1 
ATOM   1952 N  NE     . ARG   A 1 271 ? 116.013 117.073 -39.271 1.00 132.87 ?  382 ARG   A NE     1 
ATOM   1953 C  CZ     . ARG   A 1 271 ? 115.233 116.453 -38.390 1.00 148.89 ?  382 ARG   A CZ     1 
ATOM   1954 N  NH1    . ARG   A 1 271 ? 113.913 116.559 -38.474 1.00 136.45 1  382 ARG   A NH1    1 
ATOM   1955 N  NH2    . ARG   A 1 271 ? 115.766 115.719 -37.419 1.00 136.78 ?  382 ARG   A NH2    1 
ATOM   1956 N  N      . GLN   A 1 272 ? 122.477 117.118 -39.409 1.00 94.80  ?  383 GLN   A N      1 
ATOM   1957 C  CA     . GLN   A 1 272 ? 123.817 117.096 -38.818 1.00 93.35  ?  383 GLN   A CA     1 
ATOM   1958 C  C      . GLN   A 1 272 ? 123.853 116.373 -37.476 1.00 94.31  ?  383 GLN   A C      1 
ATOM   1959 O  O      . GLN   A 1 272 ? 123.009 116.639 -36.609 1.00 93.55  ?  383 GLN   A O      1 
ATOM   1960 C  CB     . GLN   A 1 272 ? 124.378 118.516 -38.678 1.00 94.56  ?  383 GLN   A CB     1 
ATOM   1961 C  CG     . GLN   A 1 272 ? 124.870 119.111 -39.989 1.00 109.19 ?  383 GLN   A CG     1 
ATOM   1962 C  CD     . GLN   A 1 272 ? 125.551 120.437 -39.775 1.00 128.48 ?  383 GLN   A CD     1 
ATOM   1963 O  OE1    . GLN   A 1 272 ? 124.922 121.438 -39.415 1.00 124.41 ?  383 GLN   A OE1    1 
ATOM   1964 N  NE2    . GLN   A 1 272 ? 126.855 120.475 -40.003 1.00 120.48 ?  383 GLN   A NE2    1 
ATOM   1965 N  N      A TYR   A 1 273 ? 124.823 115.452 -37.307 0.58 89.87  ?  384 TYR   A N      1 
ATOM   1966 N  N      B TYR   A 1 273 ? 124.836 115.476 -37.303 0.42 89.56  ?  384 TYR   A N      1 
ATOM   1967 C  CA     A TYR   A 1 273 ? 124.999 114.661 -36.085 0.58 89.22  ?  384 TYR   A CA     1 
ATOM   1968 C  CA     B TYR   A 1 273 ? 125.016 114.722 -36.066 0.42 88.73  ?  384 TYR   A CA     1 
ATOM   1969 C  C      A TYR   A 1 273 ? 126.466 114.532 -35.663 0.58 91.51  ?  384 TYR   A C      1 
ATOM   1970 C  C      B TYR   A 1 273 ? 126.480 114.619 -35.643 0.42 91.23  ?  384 TYR   A C      1 
ATOM   1971 O  O      A TYR   A 1 273 ? 127.361 114.569 -36.509 0.58 91.32  ?  384 TYR   A O      1 
ATOM   1972 O  O      B TYR   A 1 273 ? 127.384 114.759 -36.469 0.42 90.94  ?  384 TYR   A O      1 
ATOM   1973 C  CB     A TYR   A 1 273 ? 124.388 113.254 -36.248 0.58 90.54  ?  384 TYR   A CB     1 
ATOM   1974 C  CB     B TYR   A 1 273 ? 124.337 113.334 -36.139 0.42 89.81  ?  384 TYR   A CB     1 
ATOM   1975 C  CG     A TYR   A 1 273 ? 122.876 113.218 -36.341 0.58 92.37  ?  384 TYR   A CG     1 
ATOM   1976 C  CG     B TYR   A 1 273 ? 125.057 112.291 -36.971 0.42 91.26  ?  384 TYR   A CG     1 
ATOM   1977 C  CD1    A TYR   A 1 273 ? 122.239 112.980 -37.555 0.58 94.37  ?  384 TYR   A CD1    1 
ATOM   1978 C  CD1    B TYR   A 1 273 ? 126.035 111.475 -36.409 0.42 93.17  ?  384 TYR   A CD1    1 
ATOM   1979 C  CD2    A TYR   A 1 273 ? 122.084 113.355 -35.205 0.58 93.07  ?  384 TYR   A CD2    1 
ATOM   1980 C  CD2    B TYR   A 1 273 ? 124.699 112.059 -38.295 0.42 91.92  ?  384 TYR   A CD2    1 
ATOM   1981 C  CE1    A TYR   A 1 273 ? 120.848 112.913 -37.642 0.58 95.11  ?  384 TYR   A CE1    1 
ATOM   1982 C  CE1    B TYR   A 1 273 ? 126.685 110.499 -37.162 0.42 93.82  ?  384 TYR   A CE1    1 
ATOM   1983 C  CE2    A TYR   A 1 273 ? 120.693 113.304 -35.281 0.58 93.93  ?  384 TYR   A CE2    1 
ATOM   1984 C  CE2    B TYR   A 1 273 ? 125.333 111.076 -39.055 0.42 92.75  ?  384 TYR   A CE2    1 
ATOM   1985 C  CZ     A TYR   A 1 273 ? 120.079 113.082 -36.502 0.58 101.60 ?  384 TYR   A CZ     1 
ATOM   1986 C  CZ     B TYR   A 1 273 ? 126.313 110.285 -38.478 0.42 99.80  ?  384 TYR   A CZ     1 
ATOM   1987 O  OH     A TYR   A 1 273 ? 118.708 113.024 -36.582 0.58 102.75 ?  384 TYR   A OH     1 
ATOM   1988 O  OH     B TYR   A 1 273 ? 126.952 109.325 -39.224 0.42 100.57 ?  384 TYR   A OH     1 
ATOM   1989 N  N      . LYS   A 1 274 ? 126.699 114.355 -34.349 1.00 86.50  ?  385 LYS   A N      1 
ATOM   1990 C  CA     . LYS   A 1 274 ? 128.017 114.160 -33.741 1.00 84.75  ?  385 LYS   A CA     1 
ATOM   1991 C  C      . LYS   A 1 274 ? 127.914 112.886 -32.905 1.00 85.69  ?  385 LYS   A C      1 
ATOM   1992 O  O      . LYS   A 1 274 ? 126.961 112.739 -32.138 1.00 85.60  ?  385 LYS   A O      1 
ATOM   1993 C  CB     . LYS   A 1 274 ? 128.413 115.357 -32.865 1.00 86.55  ?  385 LYS   A CB     1 
ATOM   1994 C  CG     . LYS   A 1 274 ? 129.151 116.450 -33.619 1.00 91.67  ?  385 LYS   A CG     1 
ATOM   1995 C  CD     . LYS   A 1 274 ? 130.384 116.892 -32.854 1.00 95.02  ?  385 LYS   A CD     1 
ATOM   1996 C  CE     . LYS   A 1 274 ? 130.993 118.153 -33.408 1.00 101.17 ?  385 LYS   A CE     1 
ATOM   1997 N  NZ     . LYS   A 1 274 ? 132.271 118.479 -32.724 1.00 107.72 1  385 LYS   A NZ     1 
ATOM   1998 N  N      . VAL   A 1 275 ? 128.854 111.947 -33.090 1.00 79.46  ?  386 VAL   A N      1 
ATOM   1999 C  CA     . VAL   A 1 275 ? 128.861 110.665 -32.377 1.00 78.10  ?  386 VAL   A CA     1 
ATOM   2000 C  C      . VAL   A 1 275 ? 129.208 110.846 -30.889 1.00 79.31  ?  386 VAL   A C      1 
ATOM   2001 O  O      . VAL   A 1 275 ? 130.164 111.548 -30.557 1.00 78.61  ?  386 VAL   A O      1 
ATOM   2002 C  CB     . VAL   A 1 275 ? 129.766 109.616 -33.096 1.00 81.91  ?  386 VAL   A CB     1 
ATOM   2003 C  CG1    . VAL   A 1 275 ? 130.021 108.380 -32.232 1.00 81.47  ?  386 VAL   A CG1    1 
ATOM   2004 C  CG2    . VAL   A 1 275 ? 129.167 109.212 -34.443 1.00 81.76  ?  386 VAL   A CG2    1 
ATOM   2005 N  N      . TYR   A 1 276 ? 128.412 110.222 -30.004 1.00 74.21  ?  387 TYR   A N      1 
ATOM   2006 C  CA     . TYR   A 1 276 ? 128.628 110.241 -28.558 1.00 73.11  ?  387 TYR   A CA     1 
ATOM   2007 C  C      . TYR   A 1 276 ? 128.555 108.808 -28.025 1.00 76.18  ?  387 TYR   A C      1 
ATOM   2008 O  O      . TYR   A 1 276 ? 127.518 108.155 -28.149 1.00 76.29  ?  387 TYR   A O      1 
ATOM   2009 C  CB     . TYR   A 1 276 ? 127.619 111.170 -27.856 1.00 73.77  ?  387 TYR   A CB     1 
ATOM   2010 C  CG     . TYR   A 1 276 ? 127.683 111.144 -26.341 1.00 74.11  ?  387 TYR   A CG     1 
ATOM   2011 C  CD1    . TYR   A 1 276 ? 128.853 111.478 -25.666 1.00 75.60  ?  387 TYR   A CD1    1 
ATOM   2012 C  CD2    . TYR   A 1 276 ? 126.565 110.810 -25.582 1.00 74.32  ?  387 TYR   A CD2    1 
ATOM   2013 C  CE1    . TYR   A 1 276 ? 128.912 111.474 -24.277 1.00 75.43  ?  387 TYR   A CE1    1 
ATOM   2014 C  CE2    . TYR   A 1 276 ? 126.619 110.783 -24.190 1.00 74.60  ?  387 TYR   A CE2    1 
ATOM   2015 C  CZ     . TYR   A 1 276 ? 127.791 111.133 -23.541 1.00 79.69  ?  387 TYR   A CZ     1 
ATOM   2016 O  OH     . TYR   A 1 276 ? 127.871 111.119 -22.170 1.00 76.29  ?  387 TYR   A OH     1 
ATOM   2017 N  N      . ARG   A 1 277 ? 129.668 108.314 -27.466 1.00 71.50  ?  388 ARG   A N      1 
ATOM   2018 C  CA     . ARG   A 1 277 ? 129.761 106.952 -26.938 1.00 70.97  ?  388 ARG   A CA     1 
ATOM   2019 C  C      . ARG   A 1 277 ? 130.295 106.900 -25.511 1.00 74.57  ?  388 ARG   A C      1 
ATOM   2020 O  O      . ARG   A 1 277 ? 131.052 107.780 -25.096 1.00 73.69  ?  388 ARG   A O      1 
ATOM   2021 C  CB     . ARG   A 1 277 ? 130.619 106.054 -27.855 1.00 70.19  ?  388 ARG   A CB     1 
ATOM   2022 C  CG     . ARG   A 1 277 ? 132.072 106.502 -28.016 1.00 77.81  ?  388 ARG   A CG     1 
ATOM   2023 C  CD     . ARG   A 1 277 ? 132.986 105.363 -28.405 1.00 84.00  ?  388 ARG   A CD     1 
ATOM   2024 N  NE     . ARG   A 1 277 ? 134.386 105.786 -28.424 1.00 90.69  ?  388 ARG   A NE     1 
ATOM   2025 C  CZ     . ARG   A 1 277 ? 135.231 105.546 -29.423 1.00 100.99 ?  388 ARG   A CZ     1 
ATOM   2026 N  NH1    . ARG   A 1 277 ? 134.828 104.878 -30.499 1.00 81.70  1  388 ARG   A NH1    1 
ATOM   2027 N  NH2    . ARG   A 1 277 ? 136.488 105.968 -29.353 1.00 86.06  ?  388 ARG   A NH2    1 
ATOM   2028 N  N      . GLY   A 1 278 ? 129.923 105.846 -24.794 1.00 71.18  ?  389 GLY   A N      1 
ATOM   2029 C  CA     . GLY   A 1 278 ? 130.407 105.613 -23.442 1.00 70.98  ?  389 GLY   A CA     1 
ATOM   2030 C  C      . GLY   A 1 278 ? 131.859 105.185 -23.462 1.00 73.91  ?  389 GLY   A C      1 
ATOM   2031 O  O      . GLY   A 1 278 ? 132.323 104.608 -24.449 1.00 73.35  ?  389 GLY   A O      1 
ATOM   2032 N  N      . MET   A 1 279 ? 132.591 105.473 -22.379 1.00 70.08  ?  390 MET   A N      1 
ATOM   2033 C  CA     . MET   A 1 279 ? 133.998 105.098 -22.233 1.00 69.76  ?  390 MET   A CA     1 
ATOM   2034 C  C      . MET   A 1 279 ? 134.172 103.584 -21.995 1.00 73.84  ?  390 MET   A C      1 
ATOM   2035 O  O      . MET   A 1 279 ? 135.295 103.075 -22.022 1.00 74.21  ?  390 MET   A O      1 
ATOM   2036 C  CB     . MET   A 1 279 ? 134.680 105.942 -21.146 1.00 71.94  ?  390 MET   A CB     1 
ATOM   2037 C  CG     . MET   A 1 279 ? 134.871 107.396 -21.551 1.00 75.32  ?  390 MET   A CG     1 
ATOM   2038 S  SD     . MET   A 1 279 ? 135.996 107.634 -22.955 1.00 78.75  ?  390 MET   A SD     1 
ATOM   2039 C  CE     . MET   A 1 279 ? 137.496 107.986 -22.089 1.00 75.51  ?  390 MET   A CE     1 
ATOM   2040 N  N      . GLY   A 1 280 ? 133.049 102.894 -21.807 1.00 69.83  ?  391 GLY   A N      1 
ATOM   2041 C  CA     . GLY   A 1 280 ? 132.969 101.455 -21.600 1.00 70.01  ?  391 GLY   A CA     1 
ATOM   2042 C  C      . GLY   A 1 280 ? 132.235 100.734 -22.713 1.00 75.66  ?  391 GLY   A C      1 
ATOM   2043 O  O      . GLY   A 1 280 ? 131.771 99.607  -22.521 1.00 75.05  ?  391 GLY   A O      1 
ATOM   2044 N  N      . SER   A 1 281 ? 132.110 101.390 -23.882 1.00 74.08  ?  392 SER   A N      1 
ATOM   2045 C  CA     . SER   A 1 281 ? 131.502 100.821 -25.084 1.00 74.77  ?  392 SER   A CA     1 
ATOM   2046 C  C      . SER   A 1 281 ? 132.617 100.123 -25.867 1.00 81.50  ?  392 SER   A C      1 
ATOM   2047 O  O      . SER   A 1 281 ? 133.794 100.382 -25.591 1.00 81.06  ?  392 SER   A O      1 
ATOM   2048 C  CB     . SER   A 1 281 ? 130.854 101.913 -25.930 1.00 77.73  ?  392 SER   A CB     1 
ATOM   2049 O  OG     . SER   A 1 281 ? 131.818 102.828 -26.422 1.00 86.89  ?  392 SER   A OG     1 
ATOM   2050 N  N      . LEU   A 1 282 ? 132.258 99.236  -26.824 1.00 80.04  ?  393 LEU   A N      1 
ATOM   2051 C  CA     . LEU   A 1 282 ? 133.220 98.486  -27.644 1.00 80.72  ?  393 LEU   A CA     1 
ATOM   2052 C  C      . LEU   A 1 282 ? 134.275 99.383  -28.317 1.00 85.92  ?  393 LEU   A C      1 
ATOM   2053 O  O      . LEU   A 1 282 ? 135.470 99.125  -28.156 1.00 85.52  ?  393 LEU   A O      1 
ATOM   2054 C  CB     . LEU   A 1 282 ? 132.499 97.603  -28.678 1.00 80.99  ?  393 LEU   A CB     1 
ATOM   2055 C  CG     . LEU   A 1 282 ? 131.859 96.321  -28.144 1.00 85.91  ?  393 LEU   A CG     1 
ATOM   2056 C  CD1    . LEU   A 1 282 ? 130.545 96.035  -28.843 1.00 86.02  ?  393 LEU   A CD1    1 
ATOM   2057 C  CD2    . LEU   A 1 282 ? 132.801 95.131  -28.279 1.00 88.27  ?  393 LEU   A CD2    1 
ATOM   2058 N  N      . GLY   A 1 283 ? 133.819 100.450 -28.987 1.00 83.41  ?  394 GLY   A N      1 
ATOM   2059 C  CA     . GLY   A 1 283 ? 134.652 101.425 -29.690 1.00 83.62  ?  394 GLY   A CA     1 
ATOM   2060 C  C      . GLY   A 1 283 ? 135.709 102.130 -28.856 1.00 88.62  ?  394 GLY   A C      1 
ATOM   2061 O  O      . GLY   A 1 283 ? 136.848 102.288 -29.306 1.00 88.29  ?  394 GLY   A O      1 
ATOM   2062 N  N      . ALA   A 1 284 ? 135.339 102.569 -27.639 1.00 85.84  ?  395 ALA   A N      1 
ATOM   2063 C  CA     . ALA   A 1 284 ? 136.251 103.263 -26.726 1.00 85.91  ?  395 ALA   A CA     1 
ATOM   2064 C  C      . ALA   A 1 284 ? 137.297 102.317 -26.134 1.00 90.16  ?  395 ALA   A C      1 
ATOM   2065 O  O      . ALA   A 1 284 ? 138.451 102.718 -25.980 1.00 90.25  ?  395 ALA   A O      1 
ATOM   2066 C  CB     . ALA   A 1 284 ? 135.468 103.944 -25.614 1.00 86.66  ?  395 ALA   A CB     1 
ATOM   2067 N  N      . MET   A 1 285 ? 136.902 101.064 -25.825 1.00 86.43  ?  396 MET   A N      1 
ATOM   2068 C  CA     . MET   A 1 285 ? 137.787 100.043 -25.250 1.00 86.27  ?  396 MET   A CA     1 
ATOM   2069 C  C      . MET   A 1 285 ? 138.892 99.589  -26.230 1.00 90.42  ?  396 MET   A C      1 
ATOM   2070 O  O      . MET   A 1 285 ? 139.916 99.062  -25.789 1.00 90.43  ?  396 MET   A O      1 
ATOM   2071 C  CB     . MET   A 1 285 ? 136.985 98.848  -24.680 1.00 88.51  ?  396 MET   A CB     1 
ATOM   2072 C  CG     . MET   A 1 285 ? 136.108 99.221  -23.460 1.00 91.97  ?  396 MET   A CG     1 
ATOM   2073 S  SD     . MET   A 1 285 ? 135.201 97.873  -22.629 1.00 95.73  ?  396 MET   A SD     1 
ATOM   2074 C  CE     . MET   A 1 285 ? 134.062 97.386  -23.913 1.00 92.28  ?  396 MET   A CE     1 
ATOM   2075 N  N      . GLU   A 1 286 ? 138.701 99.836  -27.547 1.00 86.60  ?  397 GLU   A N      1 
ATOM   2076 C  CA     . GLU   A 1 286 ? 139.660 99.505  -28.607 1.00 111.14 ?  397 GLU   A CA     1 
ATOM   2077 C  C      . GLU   A 1 286 ? 140.864 100.451 -28.561 1.00 135.27 ?  397 GLU   A C      1 
ATOM   2078 O  O      . GLU   A 1 286 ? 140.703 101.663 -28.408 1.00 93.56  ?  397 GLU   A O      1 
ATOM   2079 C  CB     . GLU   A 1 286 ? 138.992 99.572  -29.992 1.00 112.45 ?  397 GLU   A CB     1 
ATOM   2080 C  CG     . GLU   A 1 286 ? 138.018 98.439  -30.278 1.00 122.04 ?  397 GLU   A CG     1 
ATOM   2081 C  CD     . GLU   A 1 286 ? 137.295 98.510  -31.612 1.00 139.98 ?  397 GLU   A CD     1 
ATOM   2082 O  OE1    . GLU   A 1 286 ? 136.855 99.616  -32.002 1.00 129.32 ?  397 GLU   A OE1    1 
ATOM   2083 O  OE2    . GLU   A 1 286 ? 137.133 97.445  -32.250 1.00 134.73 -1 397 GLU   A OE2    1 
ATOM   2084 N  N      . LYS   A 1 302 ? 139.036 89.852  -21.289 1.00 94.11  ?  413 LYS   A N      1 
ATOM   2085 C  CA     . LYS   A 1 302 ? 138.528 91.145  -21.739 1.00 93.82  ?  413 LYS   A CA     1 
ATOM   2086 C  C      . LYS   A 1 302 ? 137.201 91.501  -21.063 1.00 97.53  ?  413 LYS   A C      1 
ATOM   2087 O  O      . LYS   A 1 302 ? 136.366 90.620  -20.833 1.00 97.00  ?  413 LYS   A O      1 
ATOM   2088 C  CB     . LYS   A 1 302 ? 138.370 91.152  -23.252 1.00 94.51  ?  413 LYS   A CB     1 
ATOM   2089 N  N      . PHE   A 1 303 ? 137.018 92.802  -20.748 1.00 93.61  ?  414 PHE   A N      1 
ATOM   2090 C  CA     . PHE   A 1 303 ? 135.824 93.343  -20.088 1.00 92.80  ?  414 PHE   A CA     1 
ATOM   2091 C  C      . PHE   A 1 303 ? 134.586 93.336  -20.971 1.00 94.24  ?  414 PHE   A C      1 
ATOM   2092 O  O      . PHE   A 1 303 ? 134.665 93.672  -22.159 1.00 93.86  ?  414 PHE   A O      1 
ATOM   2093 C  CB     . PHE   A 1 303 ? 136.068 94.778  -19.578 1.00 94.68  ?  414 PHE   A CB     1 
ATOM   2094 C  CG     . PHE   A 1 303 ? 136.401 94.899  -18.108 1.00 96.41  ?  414 PHE   A CG     1 
ATOM   2095 C  CD1    . PHE   A 1 303 ? 135.503 94.468  -17.136 1.00 99.59  ?  414 PHE   A CD1    1 
ATOM   2096 C  CD2    . PHE   A 1 303 ? 137.590 95.488  -17.695 1.00 98.80  ?  414 PHE   A CD2    1 
ATOM   2097 C  CE1    . PHE   A 1 303 ? 135.812 94.579  -15.777 1.00 100.61 ?  414 PHE   A CE1    1 
ATOM   2098 C  CE2    . PHE   A 1 303 ? 137.894 95.609  -16.335 1.00 101.83 ?  414 PHE   A CE2    1 
ATOM   2099 C  CZ     . PHE   A 1 303 ? 137.005 95.149  -15.385 1.00 99.93  ?  414 PHE   A CZ     1 
ATOM   2100 N  N      . VAL   A 1 304 ? 133.433 92.987  -20.370 1.00 88.37  ?  415 VAL   A N      1 
ATOM   2101 C  CA     . VAL   A 1 304 ? 132.129 92.993  -21.036 1.00 86.78  ?  415 VAL   A CA     1 
ATOM   2102 C  C      . VAL   A 1 304 ? 131.651 94.467  -21.126 1.00 87.19  ?  415 VAL   A C      1 
ATOM   2103 O  O      . VAL   A 1 304 ? 131.845 95.209  -20.158 1.00 86.26  ?  415 VAL   A O      1 
ATOM   2104 C  CB     . VAL   A 1 304 ? 131.140 92.015  -20.338 1.00 90.51  ?  415 VAL   A CB     1 
ATOM   2105 C  CG1    . VAL   A 1 304 ? 129.686 92.472  -20.436 1.00 90.30  ?  415 VAL   A CG1    1 
ATOM   2106 C  CG2    . VAL   A 1 304 ? 131.302 90.607  -20.901 1.00 90.27  ?  415 VAL   A CG2    1 
ATOM   2107 N  N      . PRO   A 1 305 ? 131.115 94.935  -22.287 1.00 81.79  ?  416 PRO   A N      1 
ATOM   2108 C  CA     . PRO   A 1 305 ? 130.720 96.354  -22.397 1.00 80.88  ?  416 PRO   A CA     1 
ATOM   2109 C  C      . PRO   A 1 305 ? 129.647 96.823  -21.411 1.00 82.23  ?  416 PRO   A C      1 
ATOM   2110 O  O      . PRO   A 1 305 ? 128.643 96.140  -21.197 1.00 81.38  ?  416 PRO   A O      1 
ATOM   2111 C  CB     . PRO   A 1 305 ? 130.265 96.489  -23.853 1.00 82.69  ?  416 PRO   A CB     1 
ATOM   2112 C  CG     . PRO   A 1 305 ? 129.889 95.106  -24.262 1.00 87.43  ?  416 PRO   A CG     1 
ATOM   2113 C  CD     . PRO   A 1 305 ? 130.855 94.212  -23.549 1.00 83.14  ?  416 PRO   A CD     1 
ATOM   2114 N  N      . GLU   A 1 306 ? 129.888 97.993  -20.804 1.00 77.34  ?  417 GLU   A N      1 
ATOM   2115 C  CA     . GLU   A 1 306 ? 129.001 98.636  -19.837 1.00 76.62  ?  417 GLU   A CA     1 
ATOM   2116 C  C      . GLU   A 1 306 ? 128.399 99.927  -20.380 1.00 79.96  ?  417 GLU   A C      1 
ATOM   2117 O  O      . GLU   A 1 306 ? 127.564 100.543 -19.715 1.00 79.93  ?  417 GLU   A O      1 
ATOM   2118 C  CB     . GLU   A 1 306 ? 129.735 98.891  -18.513 1.00 77.80  ?  417 GLU   A CB     1 
ATOM   2119 C  CG     . GLU   A 1 306 ? 129.924 97.628  -17.690 1.00 85.26  ?  417 GLU   A CG     1 
ATOM   2120 C  CD     . GLU   A 1 306 ? 130.370 97.844  -16.260 1.00 92.30  ?  417 GLU   A CD     1 
ATOM   2121 O  OE1    . GLU   A 1 306 ? 131.220 97.060  -15.780 1.00 89.05  ?  417 GLU   A OE1    1 
ATOM   2122 O  OE2    . GLU   A 1 306 ? 129.850 98.777  -15.609 1.00 75.94  -1 417 GLU   A OE2    1 
ATOM   2123 N  N      . GLY   A 1 307 ? 128.797 100.297 -21.594 1.00 76.39  ?  418 GLY   A N      1 
ATOM   2124 C  CA     . GLY   A 1 307 ? 128.328 101.493 -22.285 1.00 76.35  ?  418 GLY   A CA     1 
ATOM   2125 C  C      . GLY   A 1 307 ? 127.929 101.240 -23.724 1.00 80.44  ?  418 GLY   A C      1 
ATOM   2126 O  O      . GLY   A 1 307 ? 128.281 100.205 -24.301 1.00 79.79  ?  418 GLY   A O      1 
ATOM   2127 N  N      . ILE   A 1 308 ? 127.184 102.185 -24.313 1.00 77.47  ?  419 ILE   A N      1 
ATOM   2128 C  CA     . ILE   A 1 308 ? 126.717 102.079 -25.697 1.00 77.41  ?  419 ILE   A CA     1 
ATOM   2129 C  C      . ILE   A 1 308 ? 127.263 103.213 -26.580 1.00 82.42  ?  419 ILE   A C      1 
ATOM   2130 O  O      . ILE   A 1 308 ? 127.724 104.239 -26.074 1.00 81.49  ?  419 ILE   A O      1 
ATOM   2131 C  CB     . ILE   A 1 308 ? 125.167 101.929 -25.806 1.00 80.04  ?  419 ILE   A CB     1 
ATOM   2132 C  CG1    . ILE   A 1 308 ? 124.403 102.967 -24.953 1.00 80.16  ?  419 ILE   A CG1    1 
ATOM   2133 C  CG2    . ILE   A 1 308 ? 124.731 100.503 -25.486 1.00 80.23  ?  419 ILE   A CG2    1 
ATOM   2134 C  CD1    . ILE   A 1 308 ? 123.868 104.161 -25.726 1.00 86.02  ?  419 ILE   A CD1    1 
ATOM   2135 N  N      . GLU   A 1 309 ? 127.220 102.993 -27.907 1.00 80.52  ?  420 GLU   A N      1 
ATOM   2136 C  CA     . GLU   A 1 309 ? 127.675 103.918 -28.945 1.00 80.54  ?  420 GLU   A CA     1 
ATOM   2137 C  C      . GLU   A 1 309 ? 126.443 104.415 -29.713 1.00 84.07  ?  420 GLU   A C      1 
ATOM   2138 O  O      . GLU   A 1 309 ? 125.651 103.602 -30.204 1.00 83.57  ?  420 GLU   A O      1 
ATOM   2139 C  CB     . GLU   A 1 309 ? 128.666 103.193 -29.877 1.00 82.04  ?  420 GLU   A CB     1 
ATOM   2140 C  CG     . GLU   A 1 309 ? 129.484 104.101 -30.783 1.00 95.59  ?  420 GLU   A CG     1 
ATOM   2141 C  CD     . GLU   A 1 309 ? 130.867 103.604 -31.176 1.00 119.10 ?  420 GLU   A CD     1 
ATOM   2142 O  OE1    . GLU   A 1 309 ? 131.235 102.463 -30.812 1.00 110.75 ?  420 GLU   A OE1    1 
ATOM   2143 O  OE2    . GLU   A 1 309 ? 131.592 104.373 -31.848 1.00 115.07 -1 420 GLU   A OE2    1 
ATOM   2144 N  N      . GLY   A 1 310 ? 126.276 105.734 -29.773 1.00 80.22  ?  421 GLY   A N      1 
ATOM   2145 C  CA     . GLY   A 1 310 ? 125.143 106.357 -30.447 1.00 80.02  ?  421 GLY   A CA     1 
ATOM   2146 C  C      . GLY   A 1 310 ? 125.480 107.584 -31.271 1.00 84.35  ?  421 GLY   A C      1 
ATOM   2147 O  O      . GLY   A 1 310 ? 126.628 107.767 -31.692 1.00 84.23  ?  421 GLY   A O      1 
ATOM   2148 N  N      . ARG   A 1 311 ? 124.458 108.424 -31.520 1.00 80.55  ?  422 ARG   A N      1 
ATOM   2149 C  CA     . ARG   A 1 311 ? 124.549 109.654 -32.309 1.00 80.27  ?  422 ARG   A CA     1 
ATOM   2150 C  C      . ARG   A 1 311 ? 123.673 110.737 -31.684 1.00 84.03  ?  422 ARG   A C      1 
ATOM   2151 O  O      . ARG   A 1 311 ? 122.524 110.462 -31.326 1.00 83.33  ?  422 ARG   A O      1 
ATOM   2152 C  CB     . ARG   A 1 311 ? 124.100 109.397 -33.764 1.00 81.37  ?  422 ARG   A CB     1 
ATOM   2153 C  CG     . ARG   A 1 311 ? 125.043 108.512 -34.579 1.00 93.23  ?  422 ARG   A CG     1 
ATOM   2154 C  CD     . ARG   A 1 311 ? 124.389 107.979 -35.837 1.00 108.01 ?  422 ARG   A CD     1 
ATOM   2155 N  NE     . ARG   A 1 311 ? 125.370 107.366 -36.737 1.00 120.49 ?  422 ARG   A NE     1 
ATOM   2156 C  CZ     . ARG   A 1 311 ? 125.064 106.589 -37.773 1.00 134.61 ?  422 ARG   A CZ     1 
ATOM   2157 N  NH1    . ARG   A 1 311 ? 123.796 106.307 -38.050 1.00 121.67 1  422 ARG   A NH1    1 
ATOM   2158 N  NH2    . ARG   A 1 311 ? 126.023 106.080 -38.533 1.00 120.50 ?  422 ARG   A NH2    1 
ATOM   2159 N  N      . THR   A 1 312 ? 124.214 111.962 -31.548 1.00 80.74  ?  423 THR   A N      1 
ATOM   2160 C  CA     . THR   A 1 312 ? 123.494 113.113 -30.987 1.00 80.58  ?  423 THR   A CA     1 
ATOM   2161 C  C      . THR   A 1 312 ? 123.522 114.297 -31.958 1.00 84.22  ?  423 THR   A C      1 
ATOM   2162 O  O      . THR   A 1 312 ? 124.522 114.508 -32.644 1.00 83.67  ?  423 THR   A O      1 
ATOM   2163 C  CB     . THR   A 1 312 ? 123.970 113.461 -29.553 1.00 89.99  ?  423 THR   A CB     1 
ATOM   2164 O  OG1    . THR   A 1 312 ? 123.135 114.491 -29.019 1.00 89.86  ?  423 THR   A OG1    1 
ATOM   2165 C  CG2    . THR   A 1 312 ? 125.446 113.883 -29.475 1.00 88.61  ?  423 THR   A CG2    1 
ATOM   2166 N  N      . ALA   A 1 313 ? 122.414 115.055 -32.019 1.00 80.68  ?  424 ALA   A N      1 
ATOM   2167 C  CA     . ALA   A 1 313 ? 122.258 116.208 -32.905 1.00 80.51  ?  424 ALA   A CA     1 
ATOM   2168 C  C      . ALA   A 1 313 ? 123.297 117.295 -32.633 1.00 84.55  ?  424 ALA   A C      1 
ATOM   2169 O  O      . ALA   A 1 313 ? 123.580 117.595 -31.470 1.00 84.59  ?  424 ALA   A O      1 
ATOM   2170 C  CB     . ALA   A 1 313 ? 120.854 116.778 -32.782 1.00 81.29  ?  424 ALA   A CB     1 
ATOM   2171 N  N      . TYR   A 1 314 ? 123.881 117.856 -33.713 1.00 80.42  ?  425 TYR   A N      1 
ATOM   2172 C  CA     . TYR   A 1 314 ? 124.870 118.934 -33.666 1.00 79.84  ?  425 TYR   A CA     1 
ATOM   2173 C  C      . TYR   A 1 314 ? 124.222 120.171 -33.034 1.00 81.72  ?  425 TYR   A C      1 
ATOM   2174 O  O      . TYR   A 1 314 ? 123.177 120.630 -33.505 1.00 81.00  ?  425 TYR   A O      1 
ATOM   2175 C  CB     . TYR   A 1 314 ? 125.425 119.218 -35.079 1.00 81.64  ?  425 TYR   A CB     1 
ATOM   2176 C  CG     . TYR   A 1 314 ? 126.403 120.373 -35.162 1.00 83.94  ?  425 TYR   A CG     1 
ATOM   2177 C  CD1    . TYR   A 1 314 ? 127.722 120.230 -34.742 1.00 86.06  ?  425 TYR   A CD1    1 
ATOM   2178 C  CD2    . TYR   A 1 314 ? 126.021 121.595 -35.707 1.00 84.78  ?  425 TYR   A CD2    1 
ATOM   2179 C  CE1    . TYR   A 1 314 ? 128.627 121.287 -34.824 1.00 87.06  ?  425 TYR   A CE1    1 
ATOM   2180 C  CE2    . TYR   A 1 314 ? 126.918 122.659 -35.799 1.00 85.83  ?  425 TYR   A CE2    1 
ATOM   2181 C  CZ     . TYR   A 1 314 ? 128.221 122.501 -35.356 1.00 93.24  ?  425 TYR   A CZ     1 
ATOM   2182 O  OH     . TYR   A 1 314 ? 129.104 123.550 -35.449 1.00 93.28  ?  425 TYR   A OH     1 
ATOM   2183 N  N      . LYS   A 1 315 ? 124.811 120.653 -31.925 1.00 77.33  ?  426 LYS   A N      1 
ATOM   2184 C  CA     . LYS   A 1 315 ? 124.303 121.772 -31.125 1.00 76.82  ?  426 LYS   A CA     1 
ATOM   2185 C  C      . LYS   A 1 315 ? 124.893 123.134 -31.485 1.00 80.66  ?  426 LYS   A C      1 
ATOM   2186 O  O      . LYS   A 1 315 ? 124.281 124.162 -31.177 1.00 80.48  ?  426 LYS   A O      1 
ATOM   2187 C  CB     . LYS   A 1 315 ? 124.486 121.490 -29.621 1.00 79.22  ?  426 LYS   A CB     1 
ATOM   2188 C  CG     . LYS   A 1 315 ? 123.590 120.372 -29.085 1.00 91.16  ?  426 LYS   A CG     1 
ATOM   2189 C  CD     . LYS   A 1 315 ? 123.782 120.128 -27.589 1.00 101.32 ?  426 LYS   A CD     1 
ATOM   2190 C  CE     . LYS   A 1 315 ? 122.735 120.817 -26.745 1.00 110.90 ?  426 LYS   A CE     1 
ATOM   2191 N  NZ     . LYS   A 1 315 ? 122.861 120.461 -25.308 1.00 117.45 1  426 LYS   A NZ     1 
ATOM   2192 N  N      . GLY   A 1 316 ? 126.076 123.131 -32.100 1.00 76.57  ?  427 GLY   A N      1 
ATOM   2193 C  CA     . GLY   A 1 316 ? 126.777 124.347 -32.496 1.00 75.92  ?  427 GLY   A CA     1 
ATOM   2194 C  C      . GLY   A 1 316 ? 127.847 124.755 -31.508 1.00 78.69  ?  427 GLY   A C      1 
ATOM   2195 O  O      . GLY   A 1 316 ? 128.555 123.900 -30.977 1.00 78.23  ?  427 GLY   A O      1 
ATOM   2196 N  N      . ALA   A 1 317 ? 127.979 126.066 -31.258 1.00 74.14  ?  428 ALA   A N      1 
ATOM   2197 C  CA     . ALA   A 1 317 ? 128.974 126.611 -30.334 1.00 73.34  ?  428 ALA   A CA     1 
ATOM   2198 C  C      . ALA   A 1 317 ? 128.617 126.316 -28.871 1.00 76.31  ?  428 ALA   A C      1 
ATOM   2199 O  O      . ALA   A 1 317 ? 127.449 126.440 -28.490 1.00 76.32  ?  428 ALA   A O      1 
ATOM   2200 C  CB     . ALA   A 1 317 ? 129.114 128.109 -30.548 1.00 74.03  ?  428 ALA   A CB     1 
ATOM   2201 N  N      . LEU   A 1 318 ? 129.634 125.926 -28.062 1.00 71.68  ?  429 LEU   A N      1 
ATOM   2202 C  CA     . LEU   A 1 318 ? 129.540 125.617 -26.623 1.00 70.86  ?  429 LEU   A CA     1 
ATOM   2203 C  C      . LEU   A 1 318 ? 128.877 126.767 -25.861 1.00 74.23  ?  429 LEU   A C      1 
ATOM   2204 O  O      . LEU   A 1 318 ? 127.979 126.536 -25.048 1.00 74.19  ?  429 LEU   A O      1 
ATOM   2205 C  CB     . LEU   A 1 318 ? 130.952 125.346 -26.051 1.00 70.47  ?  429 LEU   A CB     1 
ATOM   2206 C  CG     . LEU   A 1 318 ? 131.086 125.113 -24.546 1.00 74.54  ?  429 LEU   A CG     1 
ATOM   2207 C  CD1    . LEU   A 1 318 ? 132.134 124.104 -24.264 1.00 74.55  ?  429 LEU   A CD1    1 
ATOM   2208 C  CD2    . LEU   A 1 318 ? 131.470 126.373 -23.825 1.00 77.43  ?  429 LEU   A CD2    1 
ATOM   2209 N  N      . GLN   A 1 319 ? 129.349 127.995 -26.128 1.00 69.67  ?  430 GLN   A N      1 
ATOM   2210 C  CA     . GLN   A 1 319 ? 128.905 129.259 -25.552 1.00 69.12  ?  430 GLN   A CA     1 
ATOM   2211 C  C      . GLN   A 1 319 ? 127.378 129.360 -25.501 1.00 71.09  ?  430 GLN   A C      1 
ATOM   2212 O  O      . GLN   A 1 319 ? 126.838 129.760 -24.473 1.00 70.33  ?  430 GLN   A O      1 
ATOM   2213 C  CB     . GLN   A 1 319 ? 129.503 130.418 -26.370 1.00 70.70  ?  430 GLN   A CB     1 
ATOM   2214 C  CG     . GLN   A 1 319 ? 129.497 131.769 -25.669 1.00 92.05  ?  430 GLN   A CG     1 
ATOM   2215 C  CD     . GLN   A 1 319 ? 130.161 132.823 -26.518 1.00 112.56 ?  430 GLN   A CD     1 
ATOM   2216 O  OE1    . GLN   A 1 319 ? 131.376 132.797 -26.748 1.00 106.25 ?  430 GLN   A OE1    1 
ATOM   2217 N  NE2    . GLN   A 1 319 ? 129.379 133.779 -26.996 1.00 106.68 ?  430 GLN   A NE2    1 
ATOM   2218 N  N      . ASP   A 1 320 ? 126.696 128.961 -26.597 1.00 66.79  ?  431 ASP   A N      1 
ATOM   2219 C  CA     . ASP   A 1 320 ? 125.234 128.991 -26.748 1.00 65.76  ?  431 ASP   A CA     1 
ATOM   2220 C  C      . ASP   A 1 320 ? 124.554 127.948 -25.856 1.00 68.12  ?  431 ASP   A C      1 
ATOM   2221 O  O      . ASP   A 1 320 ? 123.510 128.232 -25.271 1.00 66.32  ?  431 ASP   A O      1 
ATOM   2222 C  CB     . ASP   A 1 320 ? 124.827 128.783 -28.225 1.00 67.33  ?  431 ASP   A CB     1 
ATOM   2223 C  CG     . ASP   A 1 320 ? 125.507 129.681 -29.259 1.00 76.88  ?  431 ASP   A CG     1 
ATOM   2224 O  OD1    . ASP   A 1 320 ? 126.379 130.497 -28.868 1.00 76.41  ?  431 ASP   A OD1    1 
ATOM   2225 O  OD2    . ASP   A 1 320 ? 125.194 129.542 -30.463 1.00 83.11  -1 431 ASP   A OD2    1 
ATOM   2226 N  N      . THR   A 1 321 ? 125.155 126.742 -25.764 1.00 65.09  ?  432 THR   A N      1 
ATOM   2227 C  CA     . THR   A 1 321 ? 124.670 125.620 -24.958 1.00 64.55  ?  432 THR   A CA     1 
ATOM   2228 C  C      . THR   A 1 321 ? 124.770 125.972 -23.475 1.00 66.91  ?  432 THR   A C      1 
ATOM   2229 O  O      . THR   A 1 321 ? 123.785 125.813 -22.756 1.00 65.87  ?  432 THR   A O      1 
ATOM   2230 C  CB     . THR   A 1 321 ? 125.388 124.324 -25.369 1.00 74.79  ?  432 THR   A CB     1 
ATOM   2231 O  OG1    . THR   A 1 321 ? 125.068 124.046 -26.733 1.00 76.20  ?  432 THR   A OG1    1 
ATOM   2232 C  CG2    . THR   A 1 321 ? 125.013 123.128 -24.498 1.00 74.39  ?  432 THR   A CG2    1 
ATOM   2233 N  N      . ILE   A 1 322 ? 125.938 126.501 -23.042 1.00 62.88  ?  433 ILE   A N      1 
ATOM   2234 C  CA     . ILE   A 1 322 ? 126.191 126.925 -21.662 1.00 62.69  ?  433 ILE   A CA     1 
ATOM   2235 C  C      . ILE   A 1 322 ? 125.289 128.099 -21.280 1.00 68.51  ?  433 ILE   A C      1 
ATOM   2236 O  O      . ILE   A 1 322 ? 124.735 128.090 -20.178 1.00 69.11  ?  433 ILE   A O      1 
ATOM   2237 C  CB     . ILE   A 1 322 ? 127.705 127.184 -21.411 1.00 65.68  ?  433 ILE   A CB     1 
ATOM   2238 C  CG1    . ILE   A 1 322 ? 128.530 125.871 -21.503 1.00 65.95  ?  433 ILE   A CG1    1 
ATOM   2239 C  CG2    . ILE   A 1 322 ? 127.979 127.945 -20.096 1.00 66.21  ?  433 ILE   A CG2    1 
ATOM   2240 C  CD1    . ILE   A 1 322 ? 128.274 124.754 -20.398 1.00 73.30  ?  433 ILE   A CD1    1 
ATOM   2241 N  N      . TYR   A 1 323 ? 125.094 129.074 -22.197 1.00 65.11  ?  434 TYR   A N      1 
ATOM   2242 C  CA     . TYR   A 1 323 ? 124.203 130.211 -21.948 1.00 65.02  ?  434 TYR   A CA     1 
ATOM   2243 C  C      . TYR   A 1 323 ? 122.752 129.744 -21.735 1.00 64.88  ?  434 TYR   A C      1 
ATOM   2244 O  O      . TYR   A 1 323 ? 122.046 130.331 -20.909 1.00 64.14  ?  434 TYR   A O      1 
ATOM   2245 C  CB     . TYR   A 1 323 ? 124.286 131.274 -23.070 1.00 67.31  ?  434 TYR   A CB     1 
ATOM   2246 C  CG     . TYR   A 1 323 ? 123.442 132.505 -22.799 1.00 71.15  ?  434 TYR   A CG     1 
ATOM   2247 C  CD1    . TYR   A 1 323 ? 123.905 133.522 -21.969 1.00 73.64  ?  434 TYR   A CD1    1 
ATOM   2248 C  CD2    . TYR   A 1 323 ? 122.175 132.644 -23.360 1.00 72.85  ?  434 TYR   A CD2    1 
ATOM   2249 C  CE1    . TYR   A 1 323 ? 123.123 134.645 -21.693 1.00 75.47  ?  434 TYR   A CE1    1 
ATOM   2250 C  CE2    . TYR   A 1 323 ? 121.387 133.767 -23.099 1.00 74.61  ?  434 TYR   A CE2    1 
ATOM   2251 C  CZ     . TYR   A 1 323 ? 121.869 134.769 -22.270 1.00 84.03  ?  434 TYR   A CZ     1 
ATOM   2252 O  OH     . TYR   A 1 323 ? 121.105 135.883 -22.016 1.00 87.52  ?  434 TYR   A OH     1 
ATOM   2253 N  N      . GLN   A 1 324 ? 122.310 128.701 -22.468 1.00 59.10  ?  435 GLN   A N      1 
ATOM   2254 C  CA     . GLN   A 1 324 ? 120.947 128.178 -22.309 1.00 58.39  ?  435 GLN   A CA     1 
ATOM   2255 C  C      . GLN   A 1 324 ? 120.818 127.438 -20.979 1.00 62.00  ?  435 GLN   A C      1 
ATOM   2256 O  O      . GLN   A 1 324 ? 119.839 127.658 -20.265 1.00 62.16  ?  435 GLN   A O      1 
ATOM   2257 C  CB     . GLN   A 1 324 ? 120.518 127.270 -23.482 1.00 59.41  ?  435 GLN   A CB     1 
ATOM   2258 C  CG     . GLN   A 1 324 ? 120.308 127.982 -24.823 1.00 75.97  ?  435 GLN   A CG     1 
ATOM   2259 C  CD     . GLN   A 1 324 ? 119.250 129.064 -24.809 1.00 90.44  ?  435 GLN   A CD     1 
ATOM   2260 O  OE1    . GLN   A 1 324 ? 119.554 130.262 -24.765 1.00 82.17  ?  435 GLN   A OE1    1 
ATOM   2261 N  NE2    . GLN   A 1 324 ? 117.987 128.667 -24.891 1.00 83.07  ?  435 GLN   A NE2    1 
ATOM   2262 N  N      . LEU   A 1 325 ? 121.825 126.598 -20.637 1.00 57.45  ?  436 LEU   A N      1 
ATOM   2263 C  CA     . LEU   A 1 325 ? 121.871 125.798 -19.412 1.00 56.95  ?  436 LEU   A CA     1 
ATOM   2264 C  C      . LEU   A 1 325 ? 122.002 126.629 -18.148 1.00 60.96  ?  436 LEU   A C      1 
ATOM   2265 O  O      . LEU   A 1 325 ? 121.314 126.342 -17.173 1.00 60.17  ?  436 LEU   A O      1 
ATOM   2266 C  CB     . LEU   A 1 325 ? 123.000 124.759 -19.459 1.00 56.87  ?  436 LEU   A CB     1 
ATOM   2267 C  CG     . LEU   A 1 325 ? 122.875 123.612 -20.451 1.00 61.41  ?  436 LEU   A CG     1 
ATOM   2268 C  CD1    . LEU   A 1 325 ? 124.200 122.893 -20.583 1.00 61.89  ?  436 LEU   A CD1    1 
ATOM   2269 C  CD2    . LEU   A 1 325 ? 121.772 122.633 -20.056 1.00 63.20  ?  436 LEU   A CD2    1 
ATOM   2270 N  N      . MET   A 1 326 ? 122.880 127.647 -18.151 1.00 57.50  ?  437 MET   A N      1 
ATOM   2271 C  CA     . MET   A 1 326 ? 123.087 128.511 -16.979 1.00 57.17  ?  437 MET   A CA     1 
ATOM   2272 C  C      . MET   A 1 326 ? 121.940 129.481 -16.758 1.00 59.67  ?  437 MET   A C      1 
ATOM   2273 O  O      . MET   A 1 326 ? 121.699 129.906 -15.625 1.00 59.19  ?  437 MET   A O      1 
ATOM   2274 C  CB     . MET   A 1 326 ? 124.447 129.232 -17.023 1.00 59.66  ?  437 MET   A CB     1 
ATOM   2275 C  CG     . MET   A 1 326 ? 125.649 128.299 -16.928 1.00 63.91  ?  437 MET   A CG     1 
ATOM   2276 S  SD     . MET   A 1 326 ? 125.780 127.320 -15.399 1.00 69.24  ?  437 MET   A SD     1 
ATOM   2277 C  CE     . MET   A 1 326 ? 124.800 125.851 -15.857 1.00 65.87  ?  437 MET   A CE     1 
ATOM   2278 N  N      . GLY   A 1 327 ? 121.224 129.791 -17.831 1.00 55.63  ?  438 GLY   A N      1 
ATOM   2279 C  CA     . GLY   A 1 327 ? 120.052 130.655 -17.785 1.00 56.12  ?  438 GLY   A CA     1 
ATOM   2280 C  C      . GLY   A 1 327 ? 118.909 129.976 -17.056 1.00 60.38  ?  438 GLY   A C      1 
ATOM   2281 O  O      . GLY   A 1 327 ? 118.121 130.639 -16.376 1.00 60.18  ?  438 GLY   A O      1 
ATOM   2282 N  N      . GLY   A 1 328 ? 118.859 128.648 -17.181 1.00 56.96  ?  439 GLY   A N      1 
ATOM   2283 C  CA     . GLY   A 1 328 ? 117.879 127.791 -16.525 1.00 56.73  ?  439 GLY   A CA     1 
ATOM   2284 C  C      . GLY   A 1 328 ? 118.193 127.621 -15.055 1.00 59.25  ?  439 GLY   A C      1 
ATOM   2285 O  O      . GLY   A 1 328 ? 117.284 127.598 -14.221 1.00 57.76  ?  439 GLY   A O      1 
ATOM   2286 N  N      . VAL   A 1 329 ? 119.493 127.520 -14.732 1.00 56.55  ?  440 VAL   A N      1 
ATOM   2287 C  CA     . VAL   A 1 329 ? 119.981 127.405 -13.359 1.00 57.19  ?  440 VAL   A CA     1 
ATOM   2288 C  C      . VAL   A 1 329 ? 119.737 128.731 -12.642 1.00 63.79  ?  440 VAL   A C      1 
ATOM   2289 O  O      . VAL   A 1 329 ? 119.179 128.720 -11.546 1.00 64.78  ?  440 VAL   A O      1 
ATOM   2290 C  CB     . VAL   A 1 329 ? 121.453 126.924 -13.290 1.00 60.99  ?  440 VAL   A CB     1 
ATOM   2291 C  CG1    . VAL   A 1 329 ? 121.990 126.939 -11.856 1.00 60.78  ?  440 VAL   A CG1    1 
ATOM   2292 C  CG2    . VAL   A 1 329 ? 121.589 125.530 -13.890 1.00 60.58  ?  440 VAL   A CG2    1 
ATOM   2293 N  N      . ARG   A 1 330 ? 120.074 129.869 -13.292 1.00 61.56  ?  441 ARG   A N      1 
ATOM   2294 C  CA     . ARG   A 1 330 ? 119.854 131.216 -12.752 1.00 61.95  ?  441 ARG   A CA     1 
ATOM   2295 C  C      . ARG   A 1 330 ? 118.388 131.430 -12.433 1.00 66.38  ?  441 ARG   A C      1 
ATOM   2296 O  O      . ARG   A 1 330 ? 118.081 131.938 -11.357 1.00 65.45  ?  441 ARG   A O      1 
ATOM   2297 C  CB     . ARG   A 1 330 ? 120.352 132.301 -13.724 1.00 62.79  ?  441 ARG   A CB     1 
ATOM   2298 C  CG     . ARG   A 1 330 ? 121.860 132.484 -13.690 1.00 70.73  ?  441 ARG   A CG     1 
ATOM   2299 C  CD     . ARG   A 1 330 ? 122.337 133.659 -14.523 1.00 74.79  ?  441 ARG   A CD     1 
ATOM   2300 N  NE     . ARG   A 1 330 ? 123.759 133.919 -14.283 1.00 80.54  ?  441 ARG   A NE     1 
ATOM   2301 C  CZ     . ARG   A 1 330 ? 124.231 134.678 -13.299 1.00 90.06  ?  441 ARG   A CZ     1 
ATOM   2302 N  NH1    . ARG   A 1 330 ? 123.400 135.286 -12.463 1.00 68.71  1  441 ARG   A NH1    1 
ATOM   2303 N  NH2    . ARG   A 1 330 ? 125.538 134.840 -13.148 1.00 81.96  ?  441 ARG   A NH2    1 
ATOM   2304 N  N      . ALA   A 1 331 ? 117.484 131.007 -13.363 1.00 63.74  ?  442 ALA   A N      1 
ATOM   2305 C  CA     . ALA   A 1 331 ? 116.029 131.087 -13.232 1.00 63.57  ?  442 ALA   A CA     1 
ATOM   2306 C  C      . ALA   A 1 331 ? 115.527 130.327 -11.994 1.00 66.62  ?  442 ALA   A C      1 
ATOM   2307 O  O      . ALA   A 1 331 ? 114.730 130.876 -11.232 1.00 66.76  ?  442 ALA   A O      1 
ATOM   2308 C  CB     . ALA   A 1 331 ? 115.361 130.540 -14.484 1.00 64.67  ?  442 ALA   A CB     1 
ATOM   2309 N  N      . GLY   A 1 332 ? 116.020 129.098 -11.804 1.00 61.81  ?  443 GLY   A N      1 
ATOM   2310 C  CA     . GLY   A 1 332 ? 115.687 128.234 -10.675 1.00 60.95  ?  443 GLY   A CA     1 
ATOM   2311 C  C      . GLY   A 1 332 ? 116.192 128.779 -9.356  1.00 63.72  ?  443 GLY   A C      1 
ATOM   2312 O  O      . GLY   A 1 332 ? 115.536 128.619 -8.323  1.00 62.97  ?  443 GLY   A O      1 
ATOM   2313 N  N      . MET   A 1 333 ? 117.371 129.438 -9.384  1.00 59.87  ?  444 MET   A N      1 
ATOM   2314 C  CA     . MET   A 1 333 ? 117.945 130.061 -8.197  1.00 59.47  ?  444 MET   A CA     1 
ATOM   2315 C  C      . MET   A 1 333 ? 117.159 131.298 -7.810  1.00 63.31  ?  444 MET   A C      1 
ATOM   2316 O  O      . MET   A 1 333 ? 117.088 131.629 -6.629  1.00 63.66  ?  444 MET   A O      1 
ATOM   2317 C  CB     . MET   A 1 333 ? 119.428 130.330 -8.362  1.00 61.98  ?  444 MET   A CB     1 
ATOM   2318 C  CG     . MET   A 1 333 ? 120.250 129.141 -7.973  1.00 66.31  ?  444 MET   A CG     1 
ATOM   2319 S  SD     . MET   A 1 333 ? 121.859 129.130 -8.757  1.00 71.46  ?  444 MET   A SD     1 
ATOM   2320 C  CE     . MET   A 1 333 ? 122.800 129.999 -7.539  1.00 68.26  ?  444 MET   A CE     1 
ATOM   2321 N  N      . GLY   A 1 334 ? 116.513 131.916 -8.796  1.00 59.10  ?  445 GLY   A N      1 
ATOM   2322 C  CA     . GLY   A 1 334 ? 115.611 133.042 -8.592  1.00 59.07  ?  445 GLY   A CA     1 
ATOM   2323 C  C      . GLY   A 1 334 ? 114.288 132.561 -8.014  1.00 62.90  ?  445 GLY   A C      1 
ATOM   2324 O  O      . GLY   A 1 334 ? 113.649 133.284 -7.247  1.00 62.84  ?  445 GLY   A O      1 
ATOM   2325 N  N      . TYR   A 1 335 ? 113.869 131.321 -8.373  1.00 57.59  ?  446 TYR   A N      1 
ATOM   2326 C  CA     . TYR   A 1 335 ? 112.646 130.691 -7.868  1.00 56.40  ?  446 TYR   A CA     1 
ATOM   2327 C  C      . TYR   A 1 335 ? 112.798 130.265 -6.396  1.00 61.50  ?  446 TYR   A C      1 
ATOM   2328 O  O      . TYR   A 1 335 ? 111.891 130.485 -5.592  1.00 60.57  ?  446 TYR   A O      1 
ATOM   2329 C  CB     . TYR   A 1 335 ? 112.268 129.466 -8.723  1.00 55.85  ?  446 TYR   A CB     1 
ATOM   2330 C  CG     . TYR   A 1 335 ? 111.427 129.784 -9.938  1.00 55.46  ?  446 TYR   A CG     1 
ATOM   2331 C  CD1    . TYR   A 1 335 ? 110.134 130.278 -9.805  1.00 56.52  ?  446 TYR   A CD1    1 
ATOM   2332 C  CD2    . TYR   A 1 335 ? 111.901 129.538 -11.222 1.00 56.24  ?  446 TYR   A CD2    1 
ATOM   2333 C  CE1    . TYR   A 1 335 ? 109.349 130.563 -10.919 1.00 56.42  ?  446 TYR   A CE1    1 
ATOM   2334 C  CE2    . TYR   A 1 335 ? 111.133 129.836 -12.347 1.00 57.03  ?  446 TYR   A CE2    1 
ATOM   2335 C  CZ     . TYR   A 1 335 ? 109.849 130.334 -12.189 1.00 62.23  ?  446 TYR   A CZ     1 
ATOM   2336 O  OH     . TYR   A 1 335 ? 109.073 130.629 -13.281 1.00 59.19  ?  446 TYR   A OH     1 
ATOM   2337 N  N      . THR   A 1 336 ? 113.939 129.643 -6.067  1.00 59.21  ?  447 THR   A N      1 
ATOM   2338 C  CA     . THR   A 1 336 ? 114.278 129.132 -4.736  1.00 59.75  ?  447 THR   A CA     1 
ATOM   2339 C  C      . THR   A 1 336 ? 114.841 130.194 -3.790  1.00 67.07  ?  447 THR   A C      1 
ATOM   2340 O  O      . THR   A 1 336 ? 114.965 129.932 -2.587  1.00 67.37  ?  447 THR   A O      1 
ATOM   2341 C  CB     . THR   A 1 336 ? 115.272 127.975 -4.862  1.00 62.64  ?  447 THR   A CB     1 
ATOM   2342 O  OG1    . THR   A 1 336 ? 116.394 128.417 -5.632  1.00 59.55  ?  447 THR   A OG1    1 
ATOM   2343 C  CG2    . THR   A 1 336 ? 114.643 126.718 -5.474  1.00 57.47  ?  447 THR   A CG2    1 
ATOM   2344 N  N      . GLY   A 1 337 ? 115.191 131.361 -4.338  1.00 65.18  ?  448 GLY   A N      1 
ATOM   2345 C  CA     . GLY   A 1 337 ? 115.779 132.471 -3.592  1.00 65.09  ?  448 GLY   A CA     1 
ATOM   2346 C  C      . GLY   A 1 337 ? 117.182 132.151 -3.121  1.00 69.76  ?  448 GLY   A C      1 
ATOM   2347 O  O      . GLY   A 1 337 ? 117.561 132.497 -1.999  1.00 69.32  ?  448 GLY   A O      1 
ATOM   2348 N  N      . SER   A 1 338 ? 117.943 131.447 -3.974  1.00 67.20  ?  449 SER   A N      1 
ATOM   2349 C  CA     . SER   A 1 338 ? 119.307 131.007 -3.709  1.00 67.29  ?  449 SER   A CA     1 
ATOM   2350 C  C      . SER   A 1 338 ? 120.294 132.003 -4.328  1.00 73.86  ?  449 SER   A C      1 
ATOM   2351 O  O      . SER   A 1 338 ? 120.543 131.956 -5.539  1.00 73.71  ?  449 SER   A O      1 
ATOM   2352 C  CB     . SER   A 1 338 ? 119.515 129.594 -4.249  1.00 68.82  ?  449 SER   A CB     1 
ATOM   2353 O  OG     . SER   A 1 338 ? 118.540 128.701 -3.735  1.00 71.41  ?  449 SER   A OG     1 
ATOM   2354 N  N      . HIS   A 1 339 ? 120.822 132.936 -3.499  1.00 71.82  ?  450 HIS   A N      1 
ATOM   2355 C  CA     . HIS   A 1 339 ? 121.750 133.991 -3.938  1.00 71.88  ?  450 HIS   A CA     1 
ATOM   2356 C  C      . HIS   A 1 339 ? 123.082 133.431 -4.442  1.00 74.86  ?  450 HIS   A C      1 
ATOM   2357 O  O      . HIS   A 1 339 ? 123.722 134.049 -5.293  1.00 74.29  ?  450 HIS   A O      1 
ATOM   2358 C  CB     . HIS   A 1 339 ? 121.946 135.077 -2.860  1.00 72.84  ?  450 HIS   A CB     1 
ATOM   2359 C  CG     . HIS   A 1 339 ? 122.533 134.580 -1.576  1.00 76.44  ?  450 HIS   A CG     1 
ATOM   2360 N  ND1    . HIS   A 1 339 ? 121.730 134.206 -0.513  1.00 78.32  ?  450 HIS   A ND1    1 
ATOM   2361 C  CD2    . HIS   A 1 339 ? 123.831 134.438 -1.216  1.00 78.39  ?  450 HIS   A CD2    1 
ATOM   2362 C  CE1    . HIS   A 1 339 ? 122.560 133.840 0.452   1.00 77.90  ?  450 HIS   A CE1    1 
ATOM   2363 N  NE2    . HIS   A 1 339 ? 123.835 133.958 0.074   1.00 78.20  ?  450 HIS   A NE2    1 
ATOM   2364 N  N      . ASP   A 1 340 ? 123.471 132.251 -3.939  1.00 71.20  ?  451 ASP   A N      1 
ATOM   2365 C  CA     . ASP   A 1 340 ? 124.664 131.513 -4.353  1.00 70.93  ?  451 ASP   A CA     1 
ATOM   2366 C  C      . ASP   A 1 340 ? 124.427 129.995 -4.271  1.00 74.31  ?  451 ASP   A C      1 
ATOM   2367 O  O      . ASP   A 1 340 ? 123.324 129.567 -3.918  1.00 74.45  ?  451 ASP   A O      1 
ATOM   2368 C  CB     . ASP   A 1 340 ? 125.930 131.966 -3.585  1.00 72.68  ?  451 ASP   A CB     1 
ATOM   2369 C  CG     . ASP   A 1 340 ? 125.903 131.870 -2.068  1.00 81.74  ?  451 ASP   A CG     1 
ATOM   2370 O  OD1    . ASP   A 1 340 ? 125.119 131.052 -1.530  1.00 81.30  ?  451 ASP   A OD1    1 
ATOM   2371 O  OD2    . ASP   A 1 340 ? 126.698 132.581 -1.419  1.00 88.68  -1 451 ASP   A OD2    1 
ATOM   2372 N  N      . LEU   A 1 341 ? 125.443 129.190 -4.612  1.00 69.94  ?  452 LEU   A N      1 
ATOM   2373 C  CA     . LEU   A 1 341 ? 125.339 127.736 -4.590  1.00 69.61  ?  452 LEU   A CA     1 
ATOM   2374 C  C      . LEU   A 1 341 ? 125.309 127.150 -3.180  1.00 73.34  ?  452 LEU   A C      1 
ATOM   2375 O  O      . LEU   A 1 341 ? 124.662 126.125 -2.980  1.00 73.06  ?  452 LEU   A O      1 
ATOM   2376 C  CB     . LEU   A 1 341 ? 126.435 127.074 -5.432  1.00 69.62  ?  452 LEU   A CB     1 
ATOM   2377 C  CG     . LEU   A 1 341 ? 126.494 127.420 -6.920  1.00 74.09  ?  452 LEU   A CG     1 
ATOM   2378 C  CD1    . LEU   A 1 341 ? 127.666 126.758 -7.541  1.00 73.95  ?  452 LEU   A CD1    1 
ATOM   2379 C  CD2    . LEU   A 1 341 ? 125.227 126.994 -7.661  1.00 76.72  ?  452 LEU   A CD2    1 
ATOM   2380 N  N      . ARG   A 1 342 ? 125.987 127.797 -2.203  1.00 69.58  ?  453 ARG   A N      1 
ATOM   2381 C  CA     . ARG   A 1 342 ? 125.990 127.361 -0.798  1.00 69.07  ?  453 ARG   A CA     1 
ATOM   2382 C  C      . ARG   A 1 342 ? 124.571 127.430 -0.201  1.00 70.71  ?  453 ARG   A C      1 
ATOM   2383 O  O      . ARG   A 1 342 ? 124.181 126.525 0.540   1.00 71.01  ?  453 ARG   A O      1 
ATOM   2384 C  CB     . ARG   A 1 342 ? 126.984 128.178 0.041   1.00 70.77  ?  453 ARG   A CB     1 
ATOM   2385 C  CG     . ARG   A 1 342 ? 127.763 127.334 1.050   1.00 82.56  ?  453 ARG   A CG     1 
ATOM   2386 C  CD     . ARG   A 1 342 ? 128.850 128.110 1.783   1.00 92.93  ?  453 ARG   A CD     1 
ATOM   2387 N  NE     . ARG   A 1 342 ? 129.941 128.536 0.899   1.00 100.93 ?  453 ARG   A NE     1 
ATOM   2388 C  CZ     . ARG   A 1 342 ? 130.155 129.794 0.521   1.00 112.26 ?  453 ARG   A CZ     1 
ATOM   2389 N  NH1    . ARG   A 1 342 ? 129.362 130.769 0.952   1.00 95.74  1  453 ARG   A NH1    1 
ATOM   2390 N  NH2    . ARG   A 1 342 ? 131.164 130.087 -0.288  1.00 97.65  ?  453 ARG   A NH2    1 
ATOM   2391 N  N      A GLU   A 1 343 ? 123.802 128.484 -0.544  0.54 66.16  ?  454 GLU   A N      1 
ATOM   2392 N  N      B GLU   A 1 343 ? 123.808 128.481 -0.553  0.46 66.16  ?  454 GLU   A N      1 
ATOM   2393 C  CA     A GLU   A 1 343 ? 122.424 128.660 -0.083  0.54 65.79  ?  454 GLU   A CA     1 
ATOM   2394 C  CA     B GLU   A 1 343 ? 122.427 128.700 -0.119  0.46 65.73  ?  454 GLU   A CA     1 
ATOM   2395 C  C      A GLU   A 1 343 ? 121.467 127.675 -0.772  0.54 69.49  ?  454 GLU   A C      1 
ATOM   2396 C  C      B GLU   A 1 343 ? 121.474 127.686 -0.777  0.46 69.41  ?  454 GLU   A C      1 
ATOM   2397 O  O      A GLU   A 1 343 ? 120.410 127.369 -0.219  0.54 69.34  ?  454 GLU   A O      1 
ATOM   2398 O  O      B GLU   A 1 343 ? 120.429 127.372 -0.208  0.46 69.21  ?  454 GLU   A O      1 
ATOM   2399 C  CB     A GLU   A 1 343 ? 121.951 130.108 -0.273  0.54 67.04  ?  454 GLU   A CB     1 
ATOM   2400 C  CB     B GLU   A 1 343 ? 121.996 130.143 -0.443  0.46 66.97  ?  454 GLU   A CB     1 
ATOM   2401 C  CG     A GLU   A 1 343 ? 121.051 130.575 0.858   0.54 78.08  ?  454 GLU   A CG     1 
ATOM   2402 C  CG     B GLU   A 1 343 ? 120.812 130.655 0.367   0.46 77.47  ?  454 GLU   A CG     1 
ATOM   2403 C  CD     A GLU   A 1 343 ? 119.725 131.170 0.428   0.54 98.75  ?  454 GLU   A CD     1 
ATOM   2404 C  CD     B GLU   A 1 343 ? 121.035 130.965 1.838   0.46 96.34  ?  454 GLU   A CD     1 
ATOM   2405 O  OE1    A GLU   A 1 343 ? 119.698 132.373 0.082   0.54 98.96  ?  454 GLU   A OE1    1 
ATOM   2406 O  OE1    B GLU   A 1 343 ? 122.207 131.032 2.276   0.46 87.91  ?  454 GLU   A OE1    1 
ATOM   2407 O  OE2    A GLU   A 1 343 ? 118.705 130.445 0.472   0.54 88.06  -1 454 GLU   A OE2    1 
ATOM   2408 O  OE2    B GLU   A 1 343 ? 120.025 131.168 2.550   0.46 88.53  -1 454 GLU   A OE2    1 
ATOM   2409 N  N      . LEU   A 1 344 ? 121.843 127.179 -1.969  1.00 65.34  ?  455 LEU   A N      1 
ATOM   2410 C  CA     . LEU   A 1 344 ? 121.069 126.198 -2.734  1.00 64.27  ?  455 LEU   A CA     1 
ATOM   2411 C  C      . LEU   A 1 344 ? 121.325 124.818 -2.117  1.00 67.63  ?  455 LEU   A C      1 
ATOM   2412 O  O      . LEU   A 1 344 ? 120.380 124.116 -1.763  1.00 67.58  ?  455 LEU   A O      1 
ATOM   2413 C  CB     . LEU   A 1 344 ? 121.509 126.232 -4.217  1.00 63.71  ?  455 LEU   A CB     1 
ATOM   2414 C  CG     . LEU   A 1 344 ? 120.750 125.353 -5.221  1.00 66.94  ?  455 LEU   A CG     1 
ATOM   2415 C  CD1    . LEU   A 1 344 ? 119.383 125.933 -5.556  1.00 66.22  ?  455 LEU   A CD1    1 
ATOM   2416 C  CD2    . LEU   A 1 344 ? 121.549 125.186 -6.495  1.00 67.05  ?  455 LEU   A CD2    1 
ATOM   2417 N  N      . ARG   A 1 345 ? 122.605 124.464 -1.951  1.00 63.41  ?  456 ARG   A N      1 
ATOM   2418 C  CA     . ARG   A 1 345 ? 123.069 123.202 -1.383  1.00 62.91  ?  456 ARG   A CA     1 
ATOM   2419 C  C      . ARG   A 1 345 ? 122.604 122.968 0.050   1.00 66.97  ?  456 ARG   A C      1 
ATOM   2420 O  O      . ARG   A 1 345 ? 122.397 121.818 0.428   1.00 68.19  ?  456 ARG   A O      1 
ATOM   2421 C  CB     . ARG   A 1 345 ? 124.602 123.159 -1.386  1.00 62.57  ?  456 ARG   A CB     1 
ATOM   2422 C  CG     . ARG   A 1 345 ? 125.255 122.902 -2.735  1.00 69.63  ?  456 ARG   A CG     1 
ATOM   2423 C  CD     . ARG   A 1 345 ? 126.700 122.430 -2.579  1.00 76.66  ?  456 ARG   A CD     1 
ATOM   2424 N  NE     . ARG   A 1 345 ? 127.518 123.340 -1.772  1.00 82.86  ?  456 ARG   A NE     1 
ATOM   2425 C  CZ     . ARG   A 1 345 ? 128.099 124.443 -2.234  1.00 91.78  ?  456 ARG   A CZ     1 
ATOM   2426 N  NH1    . ARG   A 1 345 ? 128.818 125.209 -1.426  1.00 78.15  1  456 ARG   A NH1    1 
ATOM   2427 N  NH2    . ARG   A 1 345 ? 127.970 124.786 -3.509  1.00 74.37  ?  456 ARG   A NH2    1 
ATOM   2428 N  N      . GLU   A 1 346 ? 122.491 124.032 0.859   1.00 61.94  ?  457 GLU   A N      1 
ATOM   2429 C  CA     . GLU   A 1 346 ? 122.157 123.904 2.278   1.00 61.14  ?  457 GLU   A CA     1 
ATOM   2430 C  C      . GLU   A 1 346 ? 120.715 124.194 2.652   1.00 63.34  ?  457 GLU   A C      1 
ATOM   2431 O  O      . GLU   A 1 346 ? 120.257 123.665 3.666   1.00 63.41  ?  457 GLU   A O      1 
ATOM   2432 C  CB     . GLU   A 1 346 ? 123.087 124.792 3.130   1.00 62.43  ?  457 GLU   A CB     1 
ATOM   2433 C  CG     . GLU   A 1 346 ? 124.542 124.347 3.167   1.00 69.38  ?  457 GLU   A CG     1 
ATOM   2434 C  CD     . GLU   A 1 346 ? 124.870 123.191 4.091   1.00 89.93  ?  457 GLU   A CD     1 
ATOM   2435 O  OE1    . GLU   A 1 346 ? 124.441 123.219 5.267   1.00 87.21  ?  457 GLU   A OE1    1 
ATOM   2436 O  OE2    . GLU   A 1 346 ? 125.610 122.281 3.653   1.00 86.12  -1 457 GLU   A OE2    1 
ATOM   2437 N  N      . GLU   A 1 347 ? 120.008 125.047 1.888   1.00 57.92  ?  458 GLU   A N      1 
ATOM   2438 C  CA     . GLU   A 1 347 ? 118.660 125.446 2.276   1.00 57.14  ?  458 GLU   A CA     1 
ATOM   2439 C  C      . GLU   A 1 347 ? 117.522 125.045 1.330   1.00 59.35  ?  458 GLU   A C      1 
ATOM   2440 O  O      . GLU   A 1 347 ? 116.385 124.977 1.802   1.00 58.34  ?  458 GLU   A O      1 
ATOM   2441 C  CB     . GLU   A 1 347 ? 118.603 126.974 2.525   1.00 58.67  ?  458 GLU   A CB     1 
ATOM   2442 C  CG     . GLU   A 1 347 ? 119.480 127.476 3.667   1.00 70.00  ?  458 GLU   A CG     1 
ATOM   2443 C  CD     . GLU   A 1 347 ? 119.165 126.911 5.042   1.00 91.52  ?  458 GLU   A CD     1 
ATOM   2444 O  OE1    . GLU   A 1 347 ? 119.961 126.081 5.535   1.00 87.23  ?  458 GLU   A OE1    1 
ATOM   2445 O  OE2    . GLU   A 1 347 ? 118.118 127.284 5.618   1.00 88.47  -1 458 GLU   A OE2    1 
ATOM   2446 N  N      . ALA   A 1 348 ? 117.787 124.822 0.015   1.00 54.90  ?  459 ALA   A N      1 
ATOM   2447 C  CA     . ALA   A 1 348 ? 116.716 124.500 -0.944  1.00 53.79  ?  459 ALA   A CA     1 
ATOM   2448 C  C      . ALA   A 1 348 ? 115.972 123.198 -0.622  1.00 54.12  ?  459 ALA   A C      1 
ATOM   2449 O  O      . ALA   A 1 348 ? 116.593 122.197 -0.266  1.00 53.54  ?  459 ALA   A O      1 
ATOM   2450 C  CB     . ALA   A 1 348 ? 117.246 124.490 -2.373  1.00 54.74  ?  459 ALA   A CB     1 
ATOM   2451 N  N      . GLN   A 1 349 ? 114.635 123.243 -0.679  1.00 48.81  ?  460 GLN   A N      1 
ATOM   2452 C  CA     . GLN   A 1 349 ? 113.791 122.080 -0.379  1.00 46.98  ?  460 GLN   A CA     1 
ATOM   2453 C  C      . GLN   A 1 349 ? 113.153 121.553 -1.639  1.00 48.16  ?  460 GLN   A C      1 
ATOM   2454 O  O      . GLN   A 1 349 ? 112.736 122.332 -2.509  1.00 46.44  ?  460 GLN   A O      1 
ATOM   2455 C  CB     . GLN   A 1 349 ? 112.703 122.396 0.663   1.00 47.93  ?  460 GLN   A CB     1 
ATOM   2456 C  CG     . GLN   A 1 349 ? 113.227 122.987 1.987   1.00 56.81  ?  460 GLN   A CG     1 
ATOM   2457 C  CD     . GLN   A 1 349 ? 114.014 122.005 2.812   1.00 61.87  ?  460 GLN   A CD     1 
ATOM   2458 O  OE1    . GLN   A 1 349 ? 113.455 121.179 3.524   1.00 56.51  ?  460 GLN   A OE1    1 
ATOM   2459 N  NE2    . GLN   A 1 349 ? 115.327 122.096 2.762   1.00 55.76  ?  460 GLN   A NE2    1 
ATOM   2460 N  N      . PHE   A 1 350 ? 113.060 120.216 -1.717  1.00 41.96  ?  461 PHE   A N      1 
ATOM   2461 C  CA     . PHE   A 1 350 ? 112.453 119.496 -2.828  1.00 40.38  ?  461 PHE   A CA     1 
ATOM   2462 C  C      . PHE   A 1 350 ? 111.131 118.893 -2.420  1.00 45.54  ?  461 PHE   A C      1 
ATOM   2463 O  O      . PHE   A 1 350 ? 110.883 118.637 -1.237  1.00 44.88  ?  461 PHE   A O      1 
ATOM   2464 C  CB     . PHE   A 1 350 ? 113.335 118.308 -3.210  1.00 41.28  ?  461 PHE   A CB     1 
ATOM   2465 C  CG     . PHE   A 1 350 ? 114.660 118.594 -3.845  1.00 41.98  ?  461 PHE   A CG     1 
ATOM   2466 C  CD1    . PHE   A 1 350 ? 114.820 118.502 -5.219  1.00 44.55  ?  461 PHE   A CD1    1 
ATOM   2467 C  CD2    . PHE   A 1 350 ? 115.778 118.863 -3.066  1.00 43.26  ?  461 PHE   A CD2    1 
ATOM   2468 C  CE1    . PHE   A 1 350 ? 116.069 118.687 -5.804  1.00 46.04  ?  461 PHE   A CE1    1 
ATOM   2469 C  CE2    . PHE   A 1 350 ? 117.025 119.059 -3.655  1.00 46.22  ?  461 PHE   A CE2    1 
ATOM   2470 C  CZ     . PHE   A 1 350 ? 117.165 118.951 -5.018  1.00 44.67  ?  461 PHE   A CZ     1 
ATOM   2471 N  N      . THR   A 1 351 ? 110.317 118.569 -3.418  1.00 43.85  ?  462 THR   A N      1 
ATOM   2472 C  CA     . THR   A 1 351 ? 109.088 117.803 -3.225  1.00 43.25  ?  462 THR   A CA     1 
ATOM   2473 C  C      . THR   A 1 351 ? 109.167 116.553 -4.077  1.00 46.69  ?  462 THR   A C      1 
ATOM   2474 O  O      . THR   A 1 351 ? 109.717 116.597 -5.179  1.00 44.99  ?  462 THR   A O      1 
ATOM   2475 C  CB     . THR   A 1 351 ? 107.811 118.598 -3.458  1.00 44.50  ?  462 THR   A CB     1 
ATOM   2476 O  OG1    . THR   A 1 351 ? 106.706 117.717 -3.202  1.00 43.42  ?  462 THR   A OG1    1 
ATOM   2477 C  CG2    . THR   A 1 351 ? 107.711 119.169 -4.871  1.00 39.98  ?  462 THR   A CG2    1 
ATOM   2478 N  N      . ARG   A 1 352 ? 108.610 115.447 -3.569  1.00 43.48  ?  463 ARG   A N      1 
ATOM   2479 C  CA     . ARG   A 1 352 ? 108.556 114.187 -4.279  1.00 43.52  ?  463 ARG   A CA     1 
ATOM   2480 C  C      . ARG   A 1 352 ? 107.204 114.094 -4.953  1.00 52.16  ?  463 ARG   A C      1 
ATOM   2481 O  O      . ARG   A 1 352 ? 106.217 114.575 -4.406  1.00 51.11  ?  463 ARG   A O      1 
ATOM   2482 C  CB     . ARG   A 1 352 ? 108.767 113.003 -3.320  1.00 40.86  ?  463 ARG   A CB     1 
ATOM   2483 C  CG     . ARG   A 1 352 ? 110.190 112.890 -2.807  1.00 43.54  ?  463 ARG   A CG     1 
ATOM   2484 C  CD     . ARG   A 1 352 ? 110.330 111.892 -1.683  1.00 48.37  ?  463 ARG   A CD     1 
ATOM   2485 N  NE     . ARG   A 1 352 ? 109.638 112.325 -0.471  1.00 55.34  ?  463 ARG   A NE     1 
ATOM   2486 C  CZ     . ARG   A 1 352 ? 108.837 111.549 0.251   1.00 71.81  ?  463 ARG   A CZ     1 
ATOM   2487 N  NH1    . ARG   A 1 352 ? 108.254 112.022 1.342   1.00 67.20  1  463 ARG   A NH1    1 
ATOM   2488 N  NH2    . ARG   A 1 352 ? 108.602 110.299 -0.120  1.00 53.14  ?  463 ARG   A NH2    1 
ATOM   2489 N  N      A MET   A 1 353 ? 107.159 113.462 -6.132  0.75 52.74  ?  464 MET   A N      1 
ATOM   2490 N  N      B MET   A 1 353 ? 107.162 113.487 -6.153  0.25 50.50  ?  464 MET   A N      1 
ATOM   2491 C  CA     A MET   A 1 353 ? 105.954 113.284 -6.950  0.75 54.04  ?  464 MET   A CA     1 
ATOM   2492 C  CA     B MET   A 1 353 ? 105.938 113.281 -6.932  0.25 51.02  ?  464 MET   A CA     1 
ATOM   2493 C  C      A MET   A 1 353 ? 106.020 111.967 -7.727  0.75 59.90  ?  464 MET   A C      1 
ATOM   2494 C  C      B MET   A 1 353 ? 106.019 112.006 -7.785  0.25 58.02  ?  464 MET   A C      1 
ATOM   2495 O  O      A MET   A 1 353 ? 107.116 111.458 -7.968  0.75 60.16  ?  464 MET   A O      1 
ATOM   2496 O  O      B MET   A 1 353 ? 107.119 111.550 -8.107  0.25 57.74  ?  464 MET   A O      1 
ATOM   2497 C  CB     A MET   A 1 353 ? 105.808 114.461 -7.934  0.75 56.92  ?  464 MET   A CB     1 
ATOM   2498 C  CB     B MET   A 1 353 ? 105.565 114.535 -7.756  0.25 53.12  ?  464 MET   A CB     1 
ATOM   2499 C  CG     A MET   A 1 353 ? 107.048 114.701 -8.804  0.75 61.13  ?  464 MET   A CG     1 
ATOM   2500 C  CG     B MET   A 1 353 ? 106.246 114.641 -9.107  0.25 56.34  ?  464 MET   A CG     1 
ATOM   2501 S  SD     A MET   A 1 353 ? 106.706 115.774 -10.201 0.75 65.67  ?  464 MET   A SD     1 
ATOM   2502 S  SD     B MET   A 1 353 ? 107.779 115.589 -9.065  0.25 59.86  ?  464 MET   A SD     1 
ATOM   2503 C  CE     A MET   A 1 353 ? 108.189 115.562 -11.130 0.75 62.35  ?  464 MET   A CE     1 
ATOM   2504 C  CE     B MET   A 1 353 ? 108.213 115.522 -10.771 0.25 56.51  ?  464 MET   A CE     1 
ATOM   2505 N  N      . GLY   A 1 354 ? 104.857 111.455 -8.138  1.00 56.78  ?  465 GLY   A N      1 
ATOM   2506 C  CA     . GLY   A 1 354 ? 104.750 110.231 -8.935  1.00 57.12  ?  465 GLY   A CA     1 
ATOM   2507 C  C      . GLY   A 1 354 ? 105.022 110.435 -10.421 1.00 63.17  ?  465 GLY   A C      1 
ATOM   2508 O  O      . GLY   A 1 354 ? 105.354 111.549 -10.844 1.00 62.91  ?  465 GLY   A O      1 
ATOM   2509 N  N      . PRO   A 1 355 ? 104.876 109.385 -11.269 1.00 60.89  ?  466 PRO   A N      1 
ATOM   2510 C  CA     . PRO   A 1 355 ? 105.138 109.568 -12.707 1.00 65.77  ?  466 PRO   A CA     1 
ATOM   2511 C  C      . PRO   A 1 355 ? 103.946 110.174 -13.444 1.00 106.31 ?  466 PRO   A C      1 
ATOM   2512 O  O      . PRO   A 1 355 ? 103.547 111.304 -13.174 1.00 71.95  ?  466 PRO   A O      1 
ATOM   2513 C  CB     . PRO   A 1 355 ? 105.440 108.144 -13.200 1.00 66.86  ?  466 PRO   A CB     1 
ATOM   2514 C  CG     . PRO   A 1 355 ? 105.325 107.232 -11.970 1.00 69.59  ?  466 PRO   A CG     1 
ATOM   2515 C  CD     . PRO   A 1 355 ? 104.505 107.988 -10.979 1.00 64.07  ?  466 PRO   A CD     1 
HETATM 2516 P  P      . IMP   B 2 .   ? 125.637 111.902 -19.092 1.00 54.16  ?  801 IMP   A P      1 
HETATM 2517 O  O1P    . IMP   B 2 .   ? 124.335 111.478 -18.499 1.00 54.47  ?  801 IMP   A O1P    1 
HETATM 2518 O  O2P    . IMP   B 2 .   ? 125.762 113.390 -19.203 1.00 54.08  ?  801 IMP   A O2P    1 
HETATM 2519 O  O3P    . IMP   B 2 .   ? 125.834 111.278 -20.449 1.00 58.90  ?  801 IMP   A O3P    1 
HETATM 2520 O  "O5'"  . IMP   B 2 .   ? 126.883 111.403 -18.171 1.00 54.25  ?  801 IMP   A "O5'"  1 
HETATM 2521 C  "C5'"  . IMP   B 2 .   ? 128.228 111.099 -18.604 1.00 55.17  ?  801 IMP   A "C5'"  1 
HETATM 2522 C  "C4'"  . IMP   B 2 .   ? 128.933 110.323 -17.517 1.00 55.83  ?  801 IMP   A "C4'"  1 
HETATM 2523 O  "O4'"  . IMP   B 2 .   ? 128.682 108.915 -17.688 1.00 57.08  ?  801 IMP   A "O4'"  1 
HETATM 2524 C  "C3'"  . IMP   B 2 .   ? 130.452 110.420 -17.505 1.00 56.79  ?  801 IMP   A "C3'"  1 
HETATM 2525 O  "O3'"  . IMP   B 2 .   ? 130.884 111.635 -16.907 1.00 55.95  ?  801 IMP   A "O3'"  1 
HETATM 2526 C  "C2'"  . IMP   B 2 .   ? 130.856 109.153 -16.738 1.00 56.49  ?  801 IMP   A "C2'"  1 
HETATM 2527 O  "O2'"  . IMP   B 2 .   ? 130.875 109.275 -15.320 1.00 56.00  ?  801 IMP   A "O2'"  1 
HETATM 2528 C  "C1'"  . IMP   B 2 .   ? 129.755 108.164 -17.145 1.00 57.72  ?  801 IMP   A "C1'"  1 
HETATM 2529 N  N9     . IMP   B 2 .   ? 130.184 107.178 -18.153 1.00 59.76  ?  801 IMP   A N9     1 
HETATM 2530 C  C8     . IMP   B 2 .   ? 131.026 107.392 -19.215 1.00 60.25  ?  801 IMP   A C8     1 
HETATM 2531 N  N7     . IMP   B 2 .   ? 131.163 106.348 -19.994 1.00 61.17  ?  801 IMP   A N7     1 
HETATM 2532 C  C5     . IMP   B 2 .   ? 130.377 105.375 -19.401 1.00 61.39  ?  801 IMP   A C5     1 
HETATM 2533 C  C6     . IMP   B 2 .   ? 130.141 104.006 -19.766 1.00 61.43  ?  801 IMP   A C6     1 
HETATM 2534 O  O6     . IMP   B 2 .   ? 130.493 103.445 -20.796 1.00 63.15  ?  801 IMP   A O6     1 
HETATM 2535 N  N1     . IMP   B 2 .   ? 129.360 103.350 -18.839 1.00 61.46  ?  801 IMP   A N1     1 
HETATM 2536 C  C2     . IMP   B 2 .   ? 128.829 103.929 -17.739 1.00 62.14  ?  801 IMP   A C2     1 
HETATM 2537 N  N3     . IMP   B 2 .   ? 128.973 105.196 -17.398 1.00 62.23  ?  801 IMP   A N3     1 
HETATM 2538 C  C4     . IMP   B 2 .   ? 129.773 105.872 -18.257 1.00 60.88  ?  801 IMP   A C4     1 
HETATM 2539 H  HOP2   . IMP   B 2 .   ? 126.108 113.991 -18.492 1.00 54.27  ?  801 IMP   A HOP2   1 
HETATM 2540 H  HOP3   . IMP   B 2 .   ? 125.989 110.297 -20.445 1.00 58.88  ?  801 IMP   A HOP3   1 
HETATM 2541 H  "H5'1" . IMP   B 2 .   ? 128.771 112.030 -18.763 1.00 55.31  ?  801 IMP   A "H5'1" 1 
HETATM 2542 H  "H5'2" . IMP   B 2 .   ? 128.165 110.553 -19.543 1.00 55.59  ?  801 IMP   A "H5'2" 1 
HETATM 2543 H  "H4'"  . IMP   B 2 .   ? 128.540 110.616 -16.545 1.00 55.24  ?  801 IMP   A "H4'"  1 
HETATM 2544 H  "H3'"  . IMP   B 2 .   ? 130.886 110.435 -18.502 1.00 56.48  ?  801 IMP   A "H3'"  1 
HETATM 2545 H  "HO3'" . IMP   B 2 .   ? 131.712 111.534 -16.370 1.00 56.10  ?  801 IMP   A "HO3'" 1 
HETATM 2546 H  "H2'"  . IMP   B 2 .   ? 131.844 108.825 -17.057 1.00 56.46  ?  801 IMP   A "H2'"  1 
HETATM 2547 H  "HO2'" . IMP   B 2 .   ? 129.956 109.536 -15.053 1.00 56.04  ?  801 IMP   A "HO2'" 1 
HETATM 2548 H  "H1'"  . IMP   B 2 .   ? 129.348 107.612 -16.299 1.00 57.58  ?  801 IMP   A "H1'"  1 
HETATM 2549 H  H8     . IMP   B 2 .   ? 131.540 108.340 -19.368 1.00 60.29  ?  801 IMP   A H8     1 
HETATM 2550 H  HN1    . IMP   B 2 .   ? 129.179 102.360 -18.961 1.00 61.26  ?  801 IMP   A HN1    1 
HETATM 2551 H  H2     . IMP   B 2 .   ? 128.270 103.299 -17.050 1.00 62.10  ?  801 IMP   A H2     1 
HETATM 2552 C  C4     . A1AG0 C 3 .   ? 134.155 98.544  -16.204 1.00 80.93  ?  802 A1AG0 A C4     1 
HETATM 2553 C  C5     . A1AG0 C 3 .   ? 134.951 98.207  -15.088 1.00 81.46  ?  802 A1AG0 A C5     1 
HETATM 2554 C  C6     . A1AG0 C 3 .   ? 136.293 98.635  -15.076 1.00 82.31  ?  802 A1AG0 A C6     1 
HETATM 2555 C  C8     . A1AG0 C 3 .   ? 136.077 99.614  -17.169 1.00 81.28  ?  802 A1AG0 A C8     1 
HETATM 2556 C  C9     . A1AG0 C 3 .   ? 134.372 97.484  -13.925 1.00 79.21  ?  802 A1AG0 A C9     1 
HETATM 2557 C  C12    . A1AG0 C 3 .   ? 133.065 96.259  -12.642 1.00 76.86  ?  802 A1AG0 A C12    1 
HETATM 2558 C  C13    . A1AG0 C 3 .   ? 134.093 96.739  -11.912 1.00 77.78  ?  802 A1AG0 A C13    1 
HETATM 2559 C  C3     . A1AG0 C 3 .   ? 134.737 99.238  -17.267 1.00 80.25  ?  802 A1AG0 A C3     1 
HETATM 2560 C  C1     . A1AG0 C 3 .   ? 133.496 98.417  -19.314 1.00 77.84  ?  802 A1AG0 A C1     1 
HETATM 2561 C  C17    . A1AG0 C 3 .   ? 132.813 101.665 -17.654 1.00 74.79  ?  802 A1AG0 A C17    1 
HETATM 2562 C  C18    . A1AG0 C 3 .   ? 133.693 102.642 -18.173 1.00 73.30  ?  802 A1AG0 A C18    1 
HETATM 2563 C  C19    . A1AG0 C 3 .   ? 133.679 103.932 -17.711 1.00 71.64  ?  802 A1AG0 A C19    1 
HETATM 2564 C  C2     . A1AG0 C 3 .   ? 133.944 99.632  -18.493 1.00 77.92  ?  802 A1AG0 A C2     1 
HETATM 2565 C  C20    . A1AG0 C 3 .   ? 132.757 104.311 -16.707 1.00 70.84  ?  802 A1AG0 A C20    1 
HETATM 2566 C  C21    . A1AG0 C 3 .   ? 131.838 103.331 -16.186 1.00 70.81  ?  802 A1AG0 A C21    1 
HETATM 2567 C  C22    . A1AG0 C 3 .   ? 131.885 102.008 -16.697 1.00 72.61  ?  802 A1AG0 A C22    1 
HETATM 2568 C  C23    . A1AG0 C 3 .   ? 130.920 103.733 -15.172 1.00 68.76  ?  802 A1AG0 A C23    1 
HETATM 2569 C  C24    . A1AG0 C 3 .   ? 130.948 105.048 -14.758 1.00 68.73  ?  802 A1AG0 A C24    1 
HETATM 2570 C  C25    . A1AG0 C 3 .   ? 131.868 105.956 -15.320 1.00 69.16  ?  802 A1AG0 A C25    1 
HETATM 2571 C  C27    . A1AG0 C 3 .   ? 130.002 105.546 -13.686 1.00 67.98  ?  802 A1AG0 A C27    1 
HETATM 2572 C  C29    . A1AG0 C 3 .   ? 129.311 103.263 -13.270 1.00 66.58  ?  802 A1AG0 A C29    1 
HETATM 2573 C  C30    . A1AG0 C 3 .   ? 129.940 102.737 -14.573 1.00 67.90  ?  802 A1AG0 A C30    1 
HETATM 2574 N  N10    . A1AG0 C 3 .   ? 133.232 96.725  -13.918 1.00 76.95  ?  802 A1AG0 A N10    1 
HETATM 2575 N  N14    . A1AG0 C 3 .   ? 134.869 97.485  -12.704 1.00 78.17  ?  802 A1AG0 A N14    1 
HETATM 2576 N  N26    . A1AG0 C 3 .   ? 132.728 105.578 -16.249 1.00 70.04  ?  802 A1AG0 A N26    1 
HETATM 2577 N  N7     . A1AG0 C 3 .   ? 136.801 99.312  -16.097 1.00 82.06  ?  802 A1AG0 A N7     1 
HETATM 2578 O  O16    . A1AG0 C 3 .   ? 132.779 100.380 -18.128 1.00 77.00  ?  802 A1AG0 A O16    1 
HETATM 2579 O  O28    . A1AG0 C 3 .   ? 128.911 104.631 -13.473 1.00 66.11  ?  802 A1AG0 A O28    1 
HETATM 2580 CL CL15   . A1AG0 C 3 .   ? 134.368 96.453  -10.225 1.00 77.61  ?  802 A1AG0 A CL15   1 
HETATM 2581 H  H11    . A1AG0 C 3 .   ? 132.651 96.542  -14.673 1.00 76.76  ?  802 A1AG0 A H11    1 
HETATM 2582 O  O      . HOH   D 4 .   ? 113.877 106.423 -8.028  1.00 66.86  ?  901 HOH   A O      1 
HETATM 2583 O  O      . HOH   D 4 .   ? 113.083 125.588 -1.701  1.00 53.57  ?  902 HOH   A O      1 
HETATM 2584 O  O      . HOH   D 4 .   ? 133.315 109.306 -24.966 1.00 61.16  ?  903 HOH   A O      1 
HETATM 2585 O  O      . HOH   D 4 .   ? 124.740 107.253 -8.830  1.00 44.42  ?  904 HOH   A O      1 
HETATM 2586 O  O      . HOH   D 4 .   ? 118.369 111.118 -15.676 1.00 69.02  ?  905 HOH   A O      1 
HETATM 2587 O  O      . HOH   D 4 .   ? 111.036 118.917 1.447   1.00 51.01  ?  906 HOH   A O      1 
HETATM 2588 O  O      . HOH   D 4 .   ? 113.741 137.322 -8.094  1.00 84.16  ?  907 HOH   A O      1 
HETATM 2589 O  O      . HOH   D 4 .   ? 122.438 105.584 -10.936 1.00 69.14  ?  908 HOH   A O      1 
HETATM 2590 O  O      . HOH   D 4 .   ? 130.106 116.963 -11.329 1.00 73.85  ?  909 HOH   A O      1 
HETATM 2591 O  O      . HOH   D 4 .   ? 138.154 105.049 -20.460 1.00 72.72  ?  910 HOH   A O      1 
HETATM 2592 O  O      . HOH   D 4 .   ? 139.241 123.724 -18.798 1.00 69.96  ?  911 HOH   A O      1 
HETATM 2593 O  O      . HOH   D 4 .   ? 117.636 128.406 -0.991  1.00 63.78  ?  912 HOH   A O      1 
HETATM 2594 O  O      . HOH   D 4 .   ? 113.223 107.967 -0.556  1.00 56.48  ?  913 HOH   A O      1 
HETATM 2595 O  O      . HOH   D 4 .   ? 114.164 115.669 -13.948 1.00 61.57  ?  914 HOH   A O      1 
HETATM 2596 O  O      . HOH   D 4 .   ? 137.574 118.892 -27.339 1.00 55.96  ?  915 HOH   A O      1 
HETATM 2597 O  O      . HOH   D 4 .   ? 116.024 110.785 -13.991 1.00 64.60  ?  916 HOH   A O      1 
HETATM 2598 O  O      . HOH   D 4 .   ? 142.662 122.474 -29.600 1.00 65.75  ?  917 HOH   A O      1 
HETATM 2599 O  O      . HOH   D 4 .   ? 121.508 104.144 -17.644 1.00 68.36  ?  918 HOH   A O      1 
HETATM 2600 O  O      . HOH   D 4 .   ? 124.935 115.978 -19.787 1.00 52.60  ?  919 HOH   A O      1 
HETATM 2601 O  O      . HOH   D 4 .   ? 134.117 111.813 -16.947 1.00 55.65  ?  920 HOH   A O      1 
HETATM 2602 O  O      . HOH   D 4 .   ? 118.856 109.116 1.205   1.00 51.44  ?  921 HOH   A O      1 
HETATM 2603 O  O      . HOH   D 4 .   ? 114.490 93.570  3.439   1.00 45.81  ?  922 HOH   A O      1 
HETATM 2604 O  O      . HOH   D 4 .   ? 134.147 133.706 -16.573 1.00 60.56  ?  923 HOH   A O      1 
HETATM 2605 O  O      . HOH   D 4 .   ? 128.665 132.595 -29.436 1.00 70.41  ?  924 HOH   A O      1 
HETATM 2606 O  O      . HOH   D 4 .   ? 128.101 108.614 -13.662 1.00 55.28  ?  925 HOH   A O      1 
HETATM 2607 O  O      . HOH   D 4 .   ? 145.299 104.788 -23.586 1.00 79.27  ?  926 HOH   A O      1 
HETATM 2608 O  O      . HOH   D 4 .   ? 109.430 108.515 -2.987  1.00 62.73  ?  927 HOH   A O      1 
HETATM 2609 O  O      . HOH   D 4 .   ? 117.361 111.000 -0.621  1.00 62.98  ?  928 HOH   A O      1 
HETATM 2610 O  O      . HOH   D 4 .   ? 110.929 126.418 0.775   1.00 56.40  ?  929 HOH   A O      1 
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