2020-07-22 REL PDBe PDBe PDBe 2020-02-11 2020-03-04 2020-03-04 2020-07-22 European Research Council (ERC) 726368 European Union Amyloid fibril structure of islet amyloid polypeptide - polymorph 3 Roeder C Kupreichyk T Gremer L Schaefer LU Pothula KR Ravelli RBG Willbold D Schroder GF Roder C Kupreichyk T Gremer L Schafer LU Pothula KR Ravelli RBG Willbold D Hoyer W Schroder GF Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-beta fibrils. Nat.Struct.Mol.Biol. US 27 660 667 2020 32541895 doi:10.1038/s41594-020-0442-4 1545-9985 Roeder C Kupreichyk T Gremer L Schaefer LU Pothula KR Ravelli RBG Willbold D Hoyer W Schroder GF Amyloid fibril structure of islet amyloid polypeptide by cryo-electron microscopy reveals similarities with amyloid beta Biorxiv US 2020 doi:10.1101/2020.02.11.944546 EMD-10669 other EM volume
10669 is the same peptide in polymorph 1
 EMD-10670 other EM volume
10670 is the same peptide in polymorph 2
 EMD-10671 associated EM volume Amyloid fibril of the islet amyloid polypeptide (IAPP) Amyloid fibril of the islet amyloid polypeptide (IAPP) 0 1
The fibril consists of IAPP monomers.
Homo sapiens 10.6 islet amyloid polypeptide Homo sapiens LEVO KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY helical filament 6 ETHANE FEI VITROBOT MARK IV
FEI TECNAI ARCTICA FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 200 OTHER FEI FALCON III (4k x 4k) COUNTING 1 1330 46.0 41.4 1 2.323 179.47 C1 8.1 FSC 0.143 CUT-OFF RELION 3.0.5 4591
noise filled cylinder
 NOT APPLICABLE emd_10671.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 220 220 220 0 0 0 220 220 220 205.7 205.7 205.7 90.0 90.0 90.0 X Y Z -0.008407407 0.017573582 0.0011355984 0.0030118295 0.935 0.935 0.935 0.008 AUTHOR emd_10671_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 220 220 220 0 0 0 220 220 220 205.7 205.7 205.7 90.0 90.0 90.0 X Y Z -0.014066297 0.015782474 0.00014284649 0.0016823935 0.935 0.935 0.935 AUTHOR half map 2 emd_10671_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 220 220 220 0 0 0 220 220 220 205.7 205.7 205.7 90.0 90.0 90.0 X Y Z -0.014066297 0.015782474 0.00014284649 0.0016823935 0.935 0.935 0.935 AUTHOR half map 1