2025-10-01 REL PDBe INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY EXPERIMENTAL_SUMMARY database_2 em_admin _database_2.pdbx_DOI _database_2.pdbx_database_accession _em_admin.last_update EXPERIMENTAL_SUMMARY em_admin _em_admin.last_update STRUCTURE_SUMMARY chem_comp_atom chem_comp_bond database_2 em_admin pdbx_entry_details pdbx_modification_feature _database_2.pdbx_DOI _database_2.pdbx_database_accession _em_admin.last_update _pdbx_entry_details.has_protein_modification STRUCTURE_SUMMARY em_admin pdbx_modification_feature pdbx_validate_close_contact struct_conn _em_admin.last_update PDBe PDBe 2019-11-07 2019-11-27 2020-08-26 2025-10-01 Leishmania tarentolae proteasome 20S subunit complexed with LXE408 and bortezomib Srinivas H Proteasome complex, inhibitor, peptidase, hydrolase Nagle A Biggart A Be C Srinivas H Hein A Caridha D Sciotti RJ Pybus B Kreishman-Deitrick M Bursulaya B Lai YH Gao MY Liang F Mathison CJN Liu X Yeh V Smith J Lerario I Xie Y Chianelli D Gibney M Berman A Chen YL Jiricek J Davis LC Liu X Ballard J Khare S Eggimann FK Luneau A Groessl T Shapiro M Richmond W Johnson K Rudewicz PJ Rao SPS Thompson C Tuntland T Spraggon G Glynne RJ Supek F Wiesmann C Molteni V Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases. J.Med.Chem. US 63 10773 10781 2020 32667203 doi:10.1021/acs.jmedchem.0c00499 0022-2623 0151 JMCMAR 6td5 FULLOVERLAP EMDB EMD-10463 associated EM volume
Leishmania tarentolae proteasome 20S subunit complexed with LXE408 and bortezomib
 Leishmania tarentolae proteasome 20S subunit complexed with LXE408 and bortezomib Leishmania tarentolae proteasome 20S subunit complexed with LXE408 and bortezomib 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Leishmania donovani Proteasome subunit alpha type Leishmania donovani 0.027178107 2 Leishmania tarentolae LEVO MNRAGFDKYITVFSPEGSLYQVEYAFKAVTYPGLLTVAIRCKDAVLVVTQHLIPDRLMRPDSVTALYEVTPNIGCCMTGR APDGRALVQRAREEASDYQYRYGVEIPIAVLAKRMGDKAQVRTQQAGLRPMGVVSTFIGMDQSDQDGSLKPQIYTVDPAG WTGGHIACAAGKKQVEAMAFLEKRQKSTELDALTQKEAAMIALAALQSAIGTAVKAKEVEVGRCTAANPAFQRVPNSEVE EWLTAVAEAD 3.4.25.1 Proteasome subunit alpha type Leishmania donovani 0.025179559 2 Leishmania tarentolae LEVO MSEAFYGLTTFSPSGKLIQIEYATTAAGKGTTALGVKATDGVVIAAKKKAPSTLVDASSIQKVFVLDEHVGCTYSGMGPD CRVLIDSARKNCQQYKLMYNEPIPISQLVRKISAIYQEFTQSGGVRPFGCSLLVAGVDANGYHLYQVDPSGTFWAWKATA IGTGSPDAKAFLEKRYTVDMELEDAVHTALLTLKEGFDGQMTSENTQVGRVVENRFEILSVDQLRDYLDQI 3.4.25.1 Proteasome subunit alpha type Leishmania donovani 0.032321437999999994 2 Leishmania tarentolae LEVO MSHRYDSRTTTFSPEGRLYQVEYAVEAIQQAGTVIGVCTKDGVVLAGEKMVPHPLFDSESMQDKNTSGEKMYKIAEHIGC SVAGVTSDAYALLNYARLSALRHQYTFQEPMAIEDLCRILCDEKQLYTQYGGVRPYGVSFLLVGWDRYYGYQLYSTEPSG DYSAWSAYAIGQNDQVAHALLKKDWHESMTLEDGMLLALRVLGKTMDTAKIDLDRVEVAVMRKVPASNIDQLLDPFKHHP KTTPRFQILTRSELKPHAERADQAREAEEKAEAERQRQQEQALES 3.4.25.1 Proteasome endopeptidase complex Leishmania donovani 0.027821605 2 Leishmania tarentolae LEVO MSYDRAITVFSPDGHLFQVEYAQEAVKKGLAAVGVLGSDSVVIAVEKKSAVKLQDSRTIRKIYKVDANIYLAFAGLSADA RVLINKAQLECQRFSLNYEDTMDVDMLVRYVAGVQQKSTQSGGSRPFGVATVIGGFNEDGKPHLWKTDPSGMCSAWRAVA IGRHDQTVIEYMEKSYKDGMSRDECVHFAIKSLLEVVESGSRNIELLVLQYKEARYLTEEELQKFVVEVEKEREEEAAAK KKRQAEQE 3.4.25.1 Proteasome subunit alpha type Leishmania donovani 0.038312316 2 Leishmania tarentolae LEVO MLLPRLFSFPVCWSRALSLVCVYHVSLSFPSNSRRLCATPLLPLPCLCKLPAGHSPRKRCLFSFLSCFLDLTYFCIISFL HSVSCHLCFPLRRTRARHPIMFTSKSEYDRGVNTFSPEGRIFQIEYAVEAIKLGSTSLGIRTPEGVVLAAEKRVPSTLVV PSSMSKIMEVDSHIAAVMSGMVADARILVEHARVESQNHRFTYNEPMSVESCTLATCDLSIQFGESGGRRKLMSRPFGVS LLIAGVDEKGPQLWQTDPSGTHTRYDAQAIGGGAEAAQSVFTERYHRNMTLEEGETLAVDILKQVMEDQLSPENIEVAVV RADDGKLHMYTPTEIKAIMSRMPE 3.4.25.1 Proteasome subunit alpha type Leishmania donovani 0.047978633 2 Leishmania tarentolae LEVO MQSRKGEGWRDTGTDSLPPFSFCCSPAFSSPLAFGGEGADGCAYILTHVCRYACIAALTLHSEGAERHMRVCVCVRRCAY NEMVLHQVVAFASLAPALHPLSPLPLPCMATTHACCGLRVRSFSLKKSEKKNQQRRLQAPDLSQKTRTRTQKEKQTLQIY LRCVMFKNEYDSDITTWSPTGRLFQIEYANEAVNNGSATVGVKGKNFVVLAALKRSPVAELSSYQEKVFEIDEHVGMSIS GLVADGRVLARYLRTECMNYRYMYSNGMPMNQMADMIGEKHQRHIQCSGKRPFGVGLLLAGYDRQGPHLYQTVPSGDVYD YKATAMGVRSQASRTYLERHFEHFSDCTLDELVTHALKALASATSEGIELNVKNTTIAIVGKDTPFTIFEEESARKYLDG FKMRPEDRVAVAEEDEEMLHEQPLDVEE 3.4.25.1 Proteasome endopeptidase complex Leishmania donovani 0.025591825999999998 2 Leishmania tarentolae LEVO MAGTGSGHDQSTDVFSAEGRVFQVEYAGKAVDNSSTAVAACCKDGVVVAVEKVHTSRMLEKGSNNRIHAVDRQAGICICG LLPDGRAIVSRARQEAENSRDIFATPIRGSVLANRVGEFMHAYTTHFAYRPFGCSAIIASYADDGPQLFVSDPSGTVAGY YGVALGKAKTVAKSELEKLDFSSLTCDEAVGKLASILHEVHDKQKDKLYEVEVAWVCDKSDRKFVHVPADMVPAETSH 3.4.25.1 Proteasome subunit beta Leishmania donovani 0.024426352 2 Leishmania tarentolae LEVO TTILAVSYNGGVVLAADSRTSSGTYVVNRASNKLTKLTKKIYCCRSGSAADTQALAERVSNYLGSYQTDIGAGVNVATAA NLFQKMCYMNRWNISAGIIVAGYDPINGGSVYSIPSGGSCVKLDYALGGSGSIFLYSFFDANYKPGMSKSECVAFCQRAV AHAYSRDGSSGGLIRTITLDADEPEDQTIPWNRSPYCMEKDPKYVTQATQNQPFSSSAKITGNRMSSTG 3.4.25.1 Proteasome subunit beta Leishmania donovani 0.024377993999999997 2 Leishmania tarentolae LEVO TTIVGVVYRDGVVLGADTRATEGSIVADKRCRKIHYMAPNIMCCGAGTSADTEAVTNMVSSHLALHRLETGKQSRVLEAL TLLKRHLYRYQGHVSAALVLGGVDVEGPFLATIAPHGSTDRLPFVTMGSGSIAAMAQLEAAYKDNMTCEEAKELVASAIR KGIFNDPYSGTQVDVCVITKDKTELTIGYDKPNERMYPRQEVLLPPGTTPVLKEEIRQLVDIVDA 3.4.25.1 Proteasome subunit beta Leishmania donovani 0.022470887 2 Leishmania tarentolae LEVO MSIMAYSGGSVMAMAGKECFVIISDNRLGEQLKTISTEVPKLHVVNDSIVYGLTGLRTDQQTFANKVQFRTEMYKLREER DITGKAFAAMITSMLYEARFGPWFVEPVIGSIDKSTGEVYLCATDLIGAPCEPEDYVCAGTAAESLHGMCEALWRPGMSP EELFEIAAQAMLSACDRDSLSGYGAVAMIVTKDKVTTRLIKGRKD 3.4.25.1 Proteasome subunit family protein Leishmania donovani 0.023065291 2 Leishmania tarentolae LEVO MAETAIAFRCKDYVMVAAAGLNAFYYIKITDAEDKITQLDTHQLVACTGENGPRVNFTEYIKCNLALNRMRQHGRHSSCE STANFMRNCLASAIRSREGAYQVNCLFAGYDTPVSEDDDGVVGPQLFYMDYLGTLQAVPYGCHGYGACFVTALLDRLWRP DLSQQEGLELMQKCCDEVKRRVIISNSYFFVKAVTKNGVEVITAVH Proteasome subunit beta Leishmania donovani 0.022565419999999996 2 Leishmania tarentolae LEVO TTTLAFRFNGGIIVAVDSRASTGQYIASQTVMKVLEINDYLLGTLAGGAADCQYWERVLGMECRLWELRNGSRITVAAAS KILANITYAYRNHGLSMGTMVAGWDQFGPSLYYVDDKGSRVKQDLFSVGSGSIYAYGVLDTGYRKDLSVEDACDLARRSI FHATYRDGASGGIVTVYHVHEKGWTKISRDDQTKLYHRYFPSQ 3.4.25.1 Proteasome subunit beta Leishmania donovani 0.03767691 2 Leishmania tarentolae LEVO MASSSPPLLPFSSFVVAVVAIHLSFRVFCVGAQSLCKCCSCVPACALPLCFSSSPSVSAEDVALALFAHPKVLTHRPTAR YSPILSLLHYAVMIEDHAEYGHNYYPQKLASSTLTLPQQGAKQQQWSPYQDNGGTTAAIAGKDFVILAGDTRLNGDFCLH SRHDQSKIFQLTPYTYMASNGMQADRLQLQQMLKYRVKWYKYNNGGKVPSTKAIAQLMSTMLYHRRFFPYYTFNMVVGLD EEGHGVCYSYDAVGSTEPFLYGTRGSAASFVEPLLDCLINRQHMTSQAPPEMTKEETLAMLKNAFTGAAERDIYTGDSVS FFIITKDGVQQESFELRKD 3.4.25.1 Proteasome subunit beta Leishmania donovani 0.024737231999999998 2 Leishmania tarentolae LEVO MASGGSVIAIKYKGGVLMAADTLLSYGSLAKWPNIPRIRLLGSHSAVCATGSYADFQMMAKQVEDNIERQKMYHNVDELS PSEVFSYLHRSIYQKRCDFDPCLCQMVFIGVRDGETFLAGVDDVGTRWEDDCIATGYGAYIALPLLRQALEKNPDGLSRG EAMRILTDCLRVLFYRECRAINKFQVADAASDGVRISEPFDVETHWEYEGYCFEKTAIIR 3.4.25.1 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE 0.000384237 6 BO2 ~{N}-[4-fluoranyl-3-[6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]phenyl]-2,4-dimethyl-1,3-oxazole-5-carboxamide 0.00044343299999999997 2 N2E singleParticle particle 3 7.5 ETHANE FEI TITAN KRIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 GATAN K2 QUANTUM (4k x 4k) 1.0 1 NONE C2 3.2 FSC 0.143 CUT-OFF 127000 MAXIMUM LIKELIHOOD MAXIMUM LIKELIHOOD emd_10463.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 300 300 300 0 0 0 300 300 300 258.0 258.0 258.0 90.0 90.0 90.0 X Y Z -0.09397874 0.14127219 0.00052507926 0.00625093 0.86 0.86 0.86 0.02 AUTHOR emd_10463_msk_1.map emd_10463_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 300 300 300 0 0 0 300 300 300 258.0 258.0 258.0 90.0 90.0 90.0 X Y Z -0.017000211 0.030860418 -0.000044649543 0.0023740572 0.86 0.86 0.86 AUTHOR emd_10463_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 300 300 300 0 0 0 300 300 300 258.0 258.0 258.0 90.0 90.0 90.0 X Y Z -0.016964952 0.029012293 -0.000045568628 0.0023857583 0.86 0.86 0.86 AUTHOR