2024-07-10 REL PDBe RCSB PDBe 2019-02-07 2019-03-27 2019-03-27 2024-07-10 Medical Research Council (United Kingdom) MC_UP_A025_1013 United Kingdom Medical Research Council (United Kingdom) MC_U105184291 United Kingdom European Union Joint Programme- Neurodegeneration Research REfrAME United Kingdom Innovative Medicines Initiative 116060 United Kingdom National Institutes of Health/National Institute on Aging (NIH/NIA) P30AG010133 United States National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) U01NS110437 United States Chronic traumatic encephalopathy Type I Tau filament Falcon B Zivanov J Tau, chronic traumatic encephalopathy, filament, amyloid, PROTEIN FIBRIL Falcon B Zivanov J Zhang W Murzin AG Garringer HJ Vidal R Crowther RA Newell KL Ghetti B Goedert M Scheres SHW Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules. Nature UK 568 420 423 2019 30894745 doi:10.1038/s41586-019-1026-5 1476-4687 0006 NATUAS 6nwp FULLOVERLAP Tau filaments extracted from the temporal cortex of a patient with chronic traumatic encephalopathy Tau filaments extracted from the temporal cortex of a patient with chronic traumatic encephalopathy 0 1 Homo sapiens Brain Temporal cortex Microtubule-associated protein tau Homo sapiens Brain Temporal cortex 0.045919870999999994 6 LEVO MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLV DEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPP GQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAK SRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTS KCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVS GDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL P10636 water 1.8015e-05 30 HOH helical tissue 0.5 7.4 20.0 Tris-HCl 100.0 NaCl Quantifoil R1.2/1.3 GOLD 300 GLOW DISCHARGE ETHANE 100 277.15 FEI VITROBOT MARK IV FEI TITAN KRIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 2.7 1.7 2.8000000000000003 130000.0 GIF Quantum LS 25 GATAN K2 SUMMIT (4k x 4k) COUNTING 9.0 55.48 1 2.37 179.4 C1 2.3 FSC 0.143 CUT-OFF RELION 3.0 113178
De novo
 NOT APPLICABLE emd_0527.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 256 256 256 0 0 0 256 256 256 294.4 294.4 294.4 90.0 90.0 90.0 X Y Z -0.035616122 0.08943692 0.00069088466 0.0043800296 1.15 1.15 1.15 0.012 AUTHOR
Fourier-space refinement of the complete atomic model against the chronic traumatic encephalopathy Type I Tau filament map was performed in REFMAC. A stack of three consecutive monomers was refined to preserve nearest-neighbour interactions for the middle chain.
Fourier shell correlation RECIPROCAL 51.700000000000003 emd_0527_msk_1.map emd_0527_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 400 400 400 0 0 0 400 400 400 421.99997 421.99997 421.99997 90.0 90.0 90.0 X Y Z -0.030416088 0.07461571 -0.000019154902 0.0029663406 1.055 1.055 1.055 AUTHOR Half map 2 emd_0527_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 400 400 400 0 0 0 400 400 400 421.99997 421.99997 421.99997 90.0 90.0 90.0 X Y Z -0.03134574 0.07285224 -0.000012205825 0.002967548 1.055 1.055 1.055 AUTHOR Half map 1